KENDLE INTERNATIONAL INC
10-K405, 1999-03-31
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>   1

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 10-K

            [X] Annual Report Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

                      For the Year Ended December 31, 1998
                                       OR

          ( ) Transition report pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

Commission File Number 000-23019

                            KENDLE INTERNATIONAL INC.

             Ohio                                        IRS Employer ID
(State or other jurisdiction                             No. 31-1274091
of incorporation or organization)

                                 700 Carew Tower
                                 441 Vine Street
                             Cincinnati, Ohio 45202
                                  513-381-5550

           Securities Registered Pursuant to Section 12(b) of the Act:
                                      None

           Securities Registered Pursuant to Section 12(g) of the Act:

                           Common Stock, No Par Value

Indicate by check mark whether the Registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the preceding 12 months (or for such shorter period that the registrant was
required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days. Yes  X  No ___
                                       ---

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405
of Regulation S-K is not contained herein, and will not be contained, to the
best of registrant's knowledge, in definitive proxy or information statements
incorporated by reference in Part III of this Form 10-K or any amendment to this
Form 10-K. [X]

As of February 26, 1999, 11,067,809 shares of no par value Common Stock were
issued and outstanding.

                       Documents Incorporated by Reference

Portions of the Registrant's Annual Report to Shareholders for the year ended
December 31, 1998 furnished to the Commission pursuant to Rule 14a-3(c) and
portions of the Registrant's Proxy Statement to be filed with the Commission for
its 1999 Annual Meeting of Shareholders are incorporated by reference in Parts
I, II and III as specified.

See Exhibit Index on page 6.
                                 11 Total Pages


<PAGE>   2



                            KENDLE INTERNATIONAL INC.
                             INDEX TO ANNUAL REPORT
                                  ON FORM 10-K

<TABLE>
<CAPTION>

Part I                                                                                           Page
<S>     <C>                                                                                     <C>
         Item 1 - Business.............................................................................3
         Item 2 - Properties...........................................................................4
         Item 3 - Legal Proceedings....................................................................4
         Item 4 - Submission of Matters to a Vote of Security Holders..................................4

Part II

         Item 5 - Market for Registrant's Common Equity and Related
                       Shareholder Matters.............................................................5
         Item 6 - Selected Financial Data..............................................................5
         Item 7 - Management's Discussion and Analysis of Financial
                       Condition and Results of Operations.............................................6
         Item 7A - Quantitative and Qualitative Information about Market Risk .........................6
         Item 8 - Financial Statements and Supplementary Data..........................................6
         Item 9 - Changes in and Disagreements with Accountants on Accounting
                       and Financial Disclosure........................................................7

Part III

         Item 10 - Directors and Executive Officers of the Registrant..................................7
         Item 11 - Executive Compensation..............................................................7
         Item 12 - Security Ownership of Certain Beneficial Owners and Management......................7
         Item 13 - Certain Relationships and Related Transactions......................................7

Part IV

         Item 14 - Exhibits, Financial Statement Schedules and Reports
                         on Form 8-K...................................................................7
</TABLE>



                                       2
<PAGE>   3



                                     PART I

                                     ITEM 1.

                                    BUSINESS
                                    --------

         Kendle International Inc. (the "Company") is a contract research
organization ("CRO") that provides a broad range of Phase I through IV clinical
research and drug development services to the pharmaceutical and biotechnology
industries. The Company augments the research and development activities of
pharmaceutical and biotechnology companies by offering high quality, value added
clinical research services and proprietary information technology designed to
reduce drug development time and expense.

         The Company believes that the outsourcing of drug development
activities by pharmaceutical and biotechnology companies has been increasing and
will continue to increase as these companies strive to increase revenues through
faster drug development while also dealing with cost containment pressures. The
CRO industry, by specializing in clinical trial management is often able to
perform the needed services with a higher level of expertise or specialization,
more quickly and at a lower cost than a customer could perform the services
internally.

         The Company's strategy is to continue to enhance its reputation as a
high-quality provider of a full range of CRO services. The Company's strategy
consists of the following key elements: (i) continue to expand its broad range
of therapeutic expertise; (ii) offer its customers "one-stop shopping" with a
full range of services that encompass the clinical research process and
complement the research and development departments of its customer; (iii)
expedite the drug development process through innovative information technology
offered via the Company's proprietary TrialWare(R) software; (iv) continue to
build a brand presence that portrays high quality work; and (v) supplement
internal growth through strategic acquisitions that expand the Company's
geographic presence and add to the Company's clinical development capabilities
in existing or new therapeutic areas or service offerings.

         The Company acquired ACER/EXCEL Inc. ("ACER/EXCEL"), a full-service CRO
headquartered in Cranford, New Jersey, in February, 1998. ACER/EXCEL provides
clients with Phase II through IV clinical services. It also provides drug
development services to the Pacific Rim, through a joint venture, which operates
a CRO, headquartered in Beijing, China.

         In January, 1999, the Company acquired Research Consultants
(International) Holdings Ltd. ("IRC") for $4.1 million in cash and 87,558 shares
of the Company's Common Stock.

         Additionally, in January, 1999, the Company acquired a minority
interest in Component Software International, Inc. ("CSI"), a software
consulting and development company for $1.6 million and 19,995 shares of the
Company's Common Stock. Concurrent with this transaction, the Company entered
into a Multi-Year Strategic Service Agreement with CSI whereby the Company will
pay CSI $7.0 million over the next four years in exchange for strategic software
consulting and development services.

         The Company's net revenues from G.D. Searle & Co. accounted for 38%,
54%, and 48% of the Company's total net revenues for the years ended December
31, 1998, 1997, and 1996, respectively.

         See Note 16 to the consolidated financial statements included on Page
48 of the Registrant's Annual Report for geographic information of the Company.


Competition
- -----------

         The Company primarily competes against in-house research and
development departments of pharmaceutical and biotechnology companies,
universities, teaching hospitals and other full-service CROs, some which possess
substantially greater capital, technical and other resources than the Company.
CROs generally compete on the basis of previous experience, medical and
scientific expertise in specific therapeutic areas, the quality of services
provided, the ability to 


                                       3
<PAGE>   4

manage large-scale trials on a global basis, medical database management
capabilities, the ability to provide statistical and regulatory services, the
ability to recruit investigators, the ability to recruit patients into studies,
the ability to integrate information technology with systems to improve the
efficiency of contract research, an international presence with strategically
located facilities, financial viability and price.

         The CRO industry is highly fragmented with several hundred CROs ranging
from small, limited-service providers to full-service, global drug development
corporations. The Company competes with the following CROs, among others:
ClinTrials Research Inc., Covance, Inc., PAREXEL International Corporation,
Pharmaceutical Product Development, Inc. and Quintiles Transnational
Corporation.

Employees
- ---------

         As of February 26, 1999, the Company had approximately 1,069 employees.
None of the Company's employees are covered by a collective bargaining
agreement.


                                     ITEM 2.

                                   PROPERTIES
                                   ----------

         The Company leases all of its facilities with the exception of the
Company-owned facility in Ely, United Kingdom. The Company's principal executive
offices are located in Cincinnati, Ohio, where it leases approximately 93,000
square feet under a lease expiring in 2006. The Company also maintains offices
in various other U.S. locations and in Europe and the Pacific Rim.

         Management believes that such offices are sufficient to meet its
present needs and does not anticipate any difficulty in securing additional
space, as needed, on terms acceptable to the Company.


                                     ITEM 3.

                                LEGAL PROCEEDINGS
                                -----------------

         The Company currently is not involved in any material litigation, nor,
to the Company's knowledge, is any material litigation currently threatened
against the Company.


                                     ITEM 4.

               SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS
               ---------------------------------------------------

         No matters were submitted to a vote of security holders during the
fourth quarter of 1998.



                                       4
<PAGE>   5




                                     PART II

                                     ITEM 5.

                         MARKET FOR REGISTRANT'S COMMON
                     EQUITY AND RELATED SHAREHOLDER MATTERS
                     --------------------------------------

         "Quarterly Financial Data" on page 29 and "Transfer Agent and Registrar
and Stock Information" on page 51 of the Registrant's Annual Report to
Shareholders for 1998 are incorporated herein by reference. The Company has not
paid dividends on its Common Stock since its initial public offering in August,
1997.

Recent Sales of Unregistered Securities
- ---------------------------------------

         In February, 1998, the Shareholders of ACER/EXCEL Inc. received a total
of 987,574 shares of the Company's Common Stock. As of February 26, 1999,
186,336 of these shares remain in a general escrow, which was established at the
acquisition date to provide indemnification of sellers' representations and
warranties.

         During the time period from October 14, 1997 to January 1, 1999, Philip
E. Beekman and Charles A. Sanders, both directors of Kendle, each received a
total of 401 shares of the Company's Common Stock pursuant to the table below:
<TABLE>
<CAPTION>
PHILIP E. BEEKMAN                           CHARLES A. SANDERS
- -----------------                           ------------------
<S>                                        <C>
October 14, 1997 - 30 Shares                October 14, 1997 - 30 
Shares December 31, 1997 -131               Shares December 31, 1997 - 131 
Shares April 1, 1998 - 81 Shares            April 1, 1998 - 81 Shares 
July 1, 1998 - 58 Shares                    July 1, 1998 - 58 Shares 
October 1, 1998 - 33 Shares                 October 1, 1998 - 33 Shares 
January 1, 1999 - 68 Shares                 January 1, 1999 - 68 Shares
</TABLE>

         Mr. Beekman and Mr. Sanders acquired these securities in exchange for
their services as directors of the Company pursuant to the 1997 Directors'
Compensation Plan.

         These issuances were exempt from registration under the Securities Act
of 1933 pursuant to Section 4(2) as transactions by an issuer not involving any
public offering.

                                     ITEM 6.

                             SELECTED FINANCIAL DATA
                             -----------------------

         "Selected Financial Data" on page 28 of the Registrant's Annual Report
to Shareholders for 1998 is incorporated herein by reference.



                                       5
<PAGE>   6



                                     ITEM 7.

                MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL
                       CONDITION AND RESULTS OF OPERATIONS
                       -----------------------------------

         "Management's Discussion and Analysis of Financial Condition and
Results of Operations" begin on page 30 of the Registrant's Annual Report to
Shareholders for 1998 is incorporated herein by reference.

                                    ITEM 7A.

           QUANTITATIVE AND QUALITATIVE INFORMATION ABOUT MARKET RISK
           ----------------------------------------------------------

                                 Not Applicable


                                     ITEM 8.

                   FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA
                   -------------------------------------------


         The following Financial Statements of the Registrant beginning on page
35 of its Annual Report to Shareholders for 1998, are incorporated herein by
reference:

         1.       Consolidated Statements of Income for the years ended December
                  31, 1998, 1997, and 1996.

         2.       Consolidated Balance Sheets as of December 31, 1998 and 1997.

         3.       Consolidated Statements of Shareholders' Equity for the years
                  ended December 31, 1998, 1997, and 1996.

         4.       Consolidated Statements of Cash Flows for the years ended
                  December 31, 1998, 1997, and 1996.

         5.       Notes to Consolidated Financial Statements.

         6.       Report of Independent Accountants.

         All supplemental schedules are omitted because of the absence of
conditions under which they are required or because the information is shown in
the Consolidated Financial Statements or Notes thereto.

Unaudited Supplementary Data
- ----------------------------

         "Selected Quarterly Financial Data" on page 29 of the Registrant's
Annual Report to Shareholders for 1998 is incorporated herein by reference.



                                       6
<PAGE>   7



                                     ITEM 9.

                  CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS
                     ON ACCOUNTING AND FINANCIAL DISCLOSURE
                     --------------------------------------

                                      None


                                    PART III

         Items 10., 11., 12. and 13. of Part III are incorporated by reference
to the Registrant's Proxy Statement for its 1999 Annual Shareholders Meeting as
filed with the Securities and Exchange Commission pursuant to Regulation 14A.


                                     PART IV

                                    ITEM 14.

         EXHIBITS, FINANCIAL STATEMENT SCHEDULES AND REPORTS ON FORM 8-K
         ---------------------------------------------------------------

         (a)  1 and 2 - All financial statements and schedules required to be
              filed by Item 8 of this Form and included in this report have been
              listed previously beginning on page 6. No additional financial
              statements or schedules are being filed since the requirements of
              paragraph (d) under Item 14 are not applicable to the Company.

         (b)  3 - Exhibits.  (see page 8)


                                       7
<PAGE>   8



<TABLE>
<CAPTION>

   Exhibit
   Number                                  Description of Exhibit                                           Filing Status
   ------                                  ----------------------                                           -------------
<S>       <C>                                                                                                 <C>
     2.1  Stock Purchase Agreement dated July 1, 1997 by and among the Company and Shareholders
          of U-Gene Research B.V.                                                                                 A

     2.2  Escrow Agreement dated June 27, 1997 among the Company, Keating, Muething & Klekamp,
          P.L.L., Bio-Medical Research Holdings, B.V., Utrechtse Particatiemaatschappij B.V.,
          P.J. Morrison, T.S. Schwarz, I.M. Hoepelman , Ph.K. Peterson, J. Remington, M.
          Rozenberg-Arska and L.G.W. Sterkman                                                                     A

     2.3  Share Purchase Agreement dated July 2, 1997 by and among the Company and the
          Shareholders of GMI Gescellschaft fur Angewandte Mathematick und Informatik mbH A 2.4                   A

     2.4  Stock Purchase Agreement dated February 11, 1998 by and among the Company and the
          Shareholders of ACER/EXCEL Inc.                                                                         B

     2.5  Escrow Agreement dated February 11, 1998 among the Company, Tzuo-Yan Lee, Jean C. Lee,
          Michael Minor, Conway Lee, Steven Lee, Jean C. Lee, as Trustee under a Trust dated
          March 8, 1991 fbo Jennifer Lee, Citicorp Trust-South Dakota and The Fifth Third Bank                    C

     2.6  Registration Rights Agreement dated February 11, 1998 among the Company and Tzuo-Yan
          Lee, Jean C. Lee, Michael Minor, Conway Lee, Steven Lee, Jean C. Lee, as Trustee under
          a Trust dated March 8, 1991 fbo Jennifer Lee, Citicorp Trust-South Dakota                               C

     2.7  Share Purchase Agreement dated December 23, 1998 by and among the Company and the
          Shareholders of Research Consultants (International) Holdings Limited                                   D

     2.8  Escrow Agreement dated January 5, 1999 among the Company, John Glasby, Gillian Gregory,
          Michael Roy Broomby and Peter Nightingale                                                               D

     2.9  Option Agreement dated September 9, 1998 by and between the Company and Component
          Software International, Inc.                                                                            D

     2.10 Notice of Option Exercise dated January 11, 1999 of the Option Agreement dated
          September 9, 1998                                                                                       D

     2.11 Multi-Year Strategic Services Agreement dated January 20, 1999 by and between the
          Company and Component Software International, Inc.                                                      D

     3.1  Restated and Amended Articles of Incorporation                                                          A

     3.2  Amended and Restated Code of Regulations                                                                A

     4    Specimen Common Stock Certificate                                                                       A

     10.1 Amended and Restated Shareholders' Agreement dated June 26, 1997                                        A

     10.2 Master Lease Agreement dated November 27, 1996 by and between the Company and Bank One
          Leasing Corporation, as amended on April 18, 1997                                                       A

     10.6 Master Equipment Lease dated August 16, 1996 by and between the Company and The Fifth
          Third Leasing Company                                                                                   A

     10.7 Lease Agreement dated December 9, 1991 by and between the Company and Carew Realty,
          Inc., as amended on December 30, 1991, March 18,1996, October 8, 1996, January 29,
          1997, and February 16, 1999                                                                             E

     10.8 Indemnity Agreement dated June 21, 1996 by and between the Company and Candace Kendle
          Bryan                                                                                                   A

     10.9 Indemnity Agreement dated June 21, 1996 by and between the Company and Christopher C.
          Bergen                                                                                                  A

    10.10 Indemnity Agreement dated June 21, 1996 by and between the Company and Timothy M.
          Mooney                                                                                                  A

    10.11 Indemnity Agreement dated May 14, 1997 by and between the Company and Charles A.
          Sanders                                                                                                 C

    10.12 Indemnity Agreement dated May 14, 1997 by and between the Company and Philip E.
          Beekman                                                                                                 C

    10.13 Indemnity Agreement dated December 10, 1998 by and between the Company and Robert Buck                  D

    10.14 Indemnity Agreement dated December 10, 1998 by and between the Company and Mary Beth
          Price                                                                                                   D
</TABLE>



                                                8
<PAGE>   9


<TABLE>
<CAPTION>
<S>       <C>                                                                                                 <C>

     10.17 Clinical Trial Service Agreement between the Company and G.D. Searle & Company dated
           September 23, 1997                                                                                     C

     10.19 Amended and Restated Credit Agreement dated as of February 26, 1998 by and between the
           Company and NationsBank, N.A.                                                                          C

     10.21 First Amendment to the Amended and Restated Credit Agreement dated as of November 25,
           1998 by and between the Company and NationsBank, N.A.                                                  D


     10.20                      MANAGEMENT CONTRACTS AND COMPENSATION PLANS

          (a)   1995 Stock Option and Stock Incentive Plan                                                        A

          (b)   1995 Stock Option and Stock Incentive Plan--Individual Stock Option Agreement
                for Incentive Stock Option (contained in Exhibit 10.20(a))                                        A

          (c)   1997 Stock Option and Stock Incentive Plan                                                        A

          (d)   Form of Protective Compensation and Benefit Agreement                                             A

          (e)   1998 Employee Stock Purchase Plan                                                                 D

          (f)   1997 Directors' Compensation Plan                                                                 D

     13   Annual Report to Shareholders for 1998                                                                  D

     21   List of Subsidiaries                                                                                    A

     23.1 Consent of PricewaterhouseCoopers LLP                                                                   D

     27.1 Financial Data Schedule for the year ended December 31, 1998                                            D
</TABLE>


Exhibit
Number                          Description of Exhibit
- ------                          ----------------------

A    Incorporated by reference to the Company's Registration Statement No.
     333-30581 filed under the Securities Act of 1933

B    Filed as an exhibit to the Company's Current Report on Form 8-K dated
     November 13, 1997

C    Incorporated by reference to the Company's Annual Report on Form 10-K for
     the year ended December 31, 1997

D    Filed herewith

E    February, 1999 amendment filed herewith



                                       9
<PAGE>   10




(c)  Reports on Form 8-K

     None



                                       10
<PAGE>   11

                                   SIGNATURES
                                   ----------

         Pursuant to the requirements of Section 13 of the Securities Exchange
Act of 1934, the Registrant has duly caused this report to be signed on its
behalf by the undersigned, thereunto duly authorized.

                            KENDLE INTERNATIONAL INC.
                            -------------------------


DATE SIGNED:  March 31, 1999                     /s/  Candace Kendle
                                                 -------------------
                                                 Candace Kendle
                                                 Chairman and CEO

         Pursuant to the requirements of the Securities Exchange Act of 1934,
this report has been signed by the following persons on behalf of the Registrant
and in the capacities and on the dates indicated.
<TABLE>
<CAPTION>
Signature                                               Capacity                         Date
- ---------                                               --------                         ----
<S>                                            <C>                                     <C>
/s/  Candace Kendle                              Chairman of the Board of                March 31, 1999
- -----------------------------------------        Directors and Chief Executive
Candace Kendle                                   Officer
                                                 


/s/ Christopher C. Bergen                        President, Chief Operating              March 31, 1999
- -----------------------------------------        Officer, Secretary and Director
Christopher C. Bergen                            


/s/ Timothy M. Mooney                            Executive Vice President,               March 31, 1999
- -----------------------------------------        Chief Financial Officer,      
Timothy M. Mooney                                Treasurer, Assistant Secretary
                                                 (Chief Accounting Officer) and
                                                 Director                      

/s/ Philip E. Beekman                            Director                                March 31, 1999
- -----------------------------------------
Philip E. Beekman


/s/ Robert R. Buck                               Director                                March 31, 1999
- -----------------------------------------
Robert R. Buck


/s/ Mary Beth Price                              Director                                March 31, 1999
- -----------------------------------------
Mary Beth Price


/s/ Charles A. Sanders                           Director                                March 31, 1999
- -----------------------------------------
Charles A. Sanders

</TABLE>


<PAGE>   1

                                                                     EXHIBIT 2.7


                            SHARE PURCHASE AGREEMENT

                                      AMONG

                                KENDLE U.K. INC.,





                                       AND


                                   JOHN GLASBY
                                 GILLIAN GREGORY
                               MICHAEL ROY BROOMBY
                                PETER NIGHTINGALE



<PAGE>   2
                                TABLE OF CONTENTS

                                                                            PAGE

1.  Definitions..............................................................  1
                                                                                
2.  Purchase and Sale of TARGET Shares.......................................  7
    (a)    Basic Transaction.................................................  8
    (b)    Purchase Price....................................................  8
    (c)    The Closing.......................................................  8
    (d)    Deliveries at the Closing.........................................  8
    (e)    Pre-emption Rights Waiver.........................................  9
    (f)    Title to the TARGET Shares........................................  9
    (g)    Purchase of all TARGET Shares.....................................  9
    (h)    Reduction of Purchase Price.......................................  9
3.  Representations and Warranties Concerning the Transaction................ 10
    (a)    Representations and Warranties of the Sellers..................... 10
       (i)     Authorisation of Transaction.................................. 11
       (ii)    Noncontravention.............................................. 11
       (iii)   Brokers' Fees................................................. 12
       (iv)    Investment Representations.................................... 12
       (v)     TARGET Shares................................................. 13
    (b)    Representations and Warranties of Kendle.......................... 13
       (i)     Organisation of Kendle and the Parent......................... 14
       (ii)    Authorisation of Transaction.................................. 14
       (iii)   Noncontravention.............................................. 14
       (iv)    Capitalisation................................................ 14
       (v)     Sec Reports................................................... 14
       (vi)    Brokers' Fees................................................. 15
                                                                                
4.  Representations and Warranties Concerning TARGET and its Subsidiaries.... 15
    (a)    Organisation, Qualification, and Corporate Power.................. 15
    (b)    Capitalisation.................................................... 15
    (c)    Noncontravention.................................................. 16
    (d)    Brokers' Fees..................................................... 16
    (e)    Title to Assets................................................... 16
    (f)    Subsidiaries...................................................... 17
    (g)    Financial Statements.............................................. 17
    (h)    Events Subsequent to Most Recent Fiscal Year End.................. 17
    (i)    Undisclosed Liabilities........................................... 20
    (j)    Legal Compliance.................................................. 20
    (k)    Tax Matters....................................................... 20
    (l)    Property.......................................................... 30
    (m)    Intellectual Property............................................. 32
    (n)    Tangible Assets................................................... 34
    (o)    Contracts......................................................... 34


<PAGE>   3
    (p)    Book Debts........................................................ 35
    (q)    Powers of Attorney................................................ 36
    (r)    Insurance......................................................... 36
    (s)    Litigation........................................................ 37
    (u)    Guarantees........................................................ 42
    (v)    Environmental, Health, and Safety Matters......................... 42
    (w)    Certain Business Relationships.................................... 43
    (x)    Competition....................................................... 43
    (y)    Disclosure ....................................................... 43
                                                                                
5.  Pre-Closing Covenants.................................................... 44
    (a)    General........................................................... 44
    (b)    Notices and Consents.............................................. 44
    (c)    Operation of Business............................................. 45
    (d)    Preservation of Business.......................................... 45
    (e)    Full Access....................................................... 45
    (f)    Notice of Developments............................................ 45

6.  Post-Closing Covenants................................................... 46
    (a)    General........................................................... 46
    (b)    Litigation Support................................................ 46
    (c)    Transition........................................................ 46
    (d)    Confidentiality................................................... 46
    (e)    TARGET Shares..................................................... 47
    (f)    Indemnities....................................................... 47
7.  Conditions to Obligation to Close........................................ 47
    (a)    Conditions to Obligation of Kendle................................ 48
    (b)    Conditions to Obligation of the Sellers........................... 50
                                                                                
8.  Remedies for Breaches of This Agreement.................................. 51
    (a)    Survival of Representations and Warranties........................ 51
    (b)    Indemnification Provisions for Benefit of Kendle.................. 52
    (c)    Indemnification Provisions for Benefit of the Sellers............. 52
    (d)    Matters Involving Third Parties................................... 53
    (e)    Payments of and Interest on Indemnification Amounts............... 54
    (f)    Other Indemnification Provisions.................................. 54
    (g)    Rights Cumulative................................................. 54
    (h)    Information....................................................... 54
    (i)    Limitations on Indemnification.................................... 55
                                                                                
9.  [Intentionally Omitted].................................................. 58

10. Termination.............................................................. 58
    (a)    Termination of Agreement.......................................... 58
    (b)    Effect of Termination............................................. 59
                                                                                
11. Miscellaneous............................................................ 59
    (a)    Nature of Certain Obligations..................................... 59
    (b)    Press Releases and Public Announcements........................... 59
    (c)    No Third-Party Beneficiaries...................................... 60
    (d)    Entire Agreement.................................................. 60
<PAGE>   4
                                     -iii-

    (c)    No Third-Party Beneficiaries...................................... 60
    (d)    Entire Agreement.................................................. 60
    (e)    Succession and Assignment......................................... 60
    (f)    Counterparts...................................................... 60
    (g)    Headings.......................................................... 60
    (h)    Notices........................................................... 60
    (i)    Governing Law..................................................... 62
    (j)    Amendments and Waivers............................................ 62
    (k)    Severability...................................................... 62
    (l)    Expenses.......................................................... 62
    (m)    Construction...................................................... 62
    (n)    Incorporation of Exhibits, Annexes, and Schedules................. 63
    (o)    Specific Performance.............................................. 63
    (p)    Address for Service............................................... 63


                                    SCHEDULES

Schedule 1          --  Sellers, Share Holdings, Purchase Price Allocation, Etc.
Schedule 2          --  Premises
Schedule 3          --  Subsidiaries
Schedule 3(b)       --  Exceptions to Kendle's Representations and Warranties
Disclosure Schedule --  Exceptions to Representations and Warranties Concerning 
                        TARGET and its Subsidiaries


                                    EXHIBITS

Exhibit 1           --  Tax Deed
Exhibit 2(b)        --  Escrow Agreement
Exhibit 4(g)        --  TARGET Financial Statements
Exhibit 7(a)(vii)   --  Employment Agreements
Exhibit 7(a)(viii)  --  Releases
Exhibit 7(a)(ix)    --  Covenants
Exhibit 7(t)(iii)   --  Specimen Existing Employment Contracts



<PAGE>   5

                            SHARE PURCHASE AGREEMENT


THIS AGREEMENT ("Agreement") is dated December 23, 1998


BETWEEN:

(1)      THE PERSONS whose names and addresses are set out on Schedule 1 (the
         "SELLERS"); and

(2)      KENDLE U.K. INC., an Ohio corporation, whose principal place of
         business is at 700 Carew Tower, 441 Vine Street, Cincinnati, Ohio
         45202, USA ("KENDLE").

                                    RECITALS

         A.       The Sellers, in the aggregate, own all of the issued share
capital of Research Consultants (International) Holdings Limited (Company No:
02756939), a private company limited by shares registered in England and Wales
and having its registered office at Angel House, 24 Station Road, Ely,
Cambridgeshire CB7 4BS ("TARGET").

         B.       This Agreement contemplates a transaction in which Kendle will
purchase from the Sellers, and the Sellers will sell to Kendle, all of the
issued share capital of TARGET in return for cash and shares of Kendle
International Inc., an Ohio corporation (the "PARENT").

THE PARTIES AGREE as follows:

         1.       DEFINITIONS.

         "ACCOUNTS" means the audited consolidated group accounts of TARGET and
its Subsidiaries, prepared in accordance with section 227 Companies Act 1985,
for the financial year ended 31 August 1998 including the notes to those
accounts and the associated directors' and auditors' reports and any profit and
loss account omitted in reliance on section 230 Companies Act 1985.

         "ADVERSE CONSEQUENCES" means all actions, suits, proceedings, hearings,
investigations, charges, complaints, claims, demands, injunctions, judgments,
orders, decrees, rulings, damages, dues, penalties, fines, costs, amounts paid
in settlement, Liabilities, obligations, Taxes, Encumbrances, losses, expenses
and fees, including (without limitation) court costs and reasonable attorneys'
fees and expenses.




<PAGE>   6
                                      -2-


         "AFFILIATE" means any Person directly or indirectly controlling,
controlled by or under direct or indirect common control of, or related to, the
Sellers, TARGET, or any of its respective direct and indirect Subsidiaries.

         "BASIS" means any known past or present fact, situation, circumstance,
status, condition, activity, practice, plan, occurrence, event, incident,
action, failure to act or transaction that forms or could form the basis for any
specified consequence.

         "BUSINESS DAY" means a day (other than a Saturday or Sunday) on which
banks are open for ordinary banking business in London and Ohio.

         "BUSINESS FACILITIES" means business facilities of any kind including,
without limitation, a loan of money or a letting, hiring or licensing of any
tangible or intangible property.

         "CASH CLOSING PAYMENT" has the meaning set forth in ss.2(b) below.

         "CLOSING" has the meaning set forth in ss.2(c) below.

         "CLOSING DATE" has the meaning set forth in ss.2(c) below.

         "CONFIDENTIAL INFORMATION" has the meaning set forth in Exhibit
7(a)(ix).

         "CURRENT USE" has the meaning set forth in ss.4(l)(v)(A).

         "COVENANTS" has the meaning set forth in ss.7(a)(ix) below.

         "DISCLOSURE SCHEDULE" means the disclosure schedule delivered by the
Parties hereto pursuant to ss.ss.3 and 4 below. Nothing contained in the
Disclosure Schedule shall be deemed adequate to disclose an exception to a
representation or warranty made in this Agreement unless the exception is
identified in the Disclosure Schedule with reasonable particularity, describing
the relevant facts in reasonable detail.

         "DOLLARS" and "$" mean dollars in the lawful currency of the United
States.

         "EMPLOYEES" has the meaning set forth in Section 4(t)(i).

         "EMPLOYMENT AGREEMENTS" has the meaning set forth in ss.7(a)(vii)
below.

         "ENCUMBRANCES" means any Security Interest, warrant, lien option,
purchase right, pre-emptive right, or other right or claim of any character that
restricts the transfer of share capital.


<PAGE>   7
                                      -3-

         "ENVIRONMENTAL LAW" means any European Union, national or local
statute, law, rule, regulation arising through statute, subordinate legislation,
or common law or any relevant code of practice, guidance, note, standard or
other advisory material issued by any competent authority relating to the
environment, health, safety, the protection of natural amenity or Hazardous
Materials, including without limitation the Health and Safety at Work etc. Act
1974, the Control of Pollution Act 1974, the Environmental Protection Act 1990,
the Water Industry Act 1991, the Water Resources Act 1991, the Statutory Water
Companies Act 1991, the Water Consolidation (Consequential Provisions) Act 1991,
the Clean Air Acts, the Alkali & c. Works Regulation Act 1906, the Planning
Hazardous Substance Act 1990, the Public Health Acts and the Radioactive
Substances Act 1960, and the Environment Act 1995.

         "ESCROW AGREEMENT" has the meaning set forth in ss.2(b) below.

         "EVENT" means any event, act, transaction, action or omission (whether
or not TARGET or any of its Subsidiaries is a party thereto).

         "FINANCIAL STATEMENTS" has the meaning set forth in ss.4(g) below.

         "HAZARDOUS MATERIALS" means (a) any petroleum or petroleum products,
radioactive materials, asbestos in any form that is or could become friable,
urea formaldehyde foam insulation, transformers or other equipment that contain
dielectric fluid containing polychlorinated biphenyls, radon gas; (b) any
chemicals, materials or substances defined as or included in the definition of
"hazardous substances," "hazardous wastes," "hazardous materials," "extremely
hazardous wastes," "restricted hazardous wastes," "toxic substances," "toxic
pollutants," "contaminants" or "pollutants," or words of similar import, under
any applicable Environmental Law; (c) any pollutant, or any hazardous, toxic,
noxious, corrosive or caustic substance whether in solid, liquid or gaseous
form; and (d) any other chemical, material or substance exposure to which is
prohibited, limited or regulated by any governmental authority.

         "INDEMNIFIED PARTY" has the meaning set forth in ss.8(d) below.

         "INDEMNIFYING PARTY" has the meaning set forth in ss.8(d) below.

         "INTELLECTUAL PROPERTY" means (a) all inventions (whether patentable or
unpatentable and whether or not reduced to practice), all improvements thereto
and all patents, patent applications, and patent disclosures, together with all
reissuances, continuations, continuations-in-part, revisions, extensions, and
re-examinations thereof, (b) all trade marks, design rights, service marks,
rights (registered or unregistered) in any designs, trade dress, logos, trade
names, together with all translations, adaptations, derivations, and
combinations thereof and including all goodwill associated therewith, and all
applications, registrations, and 


<PAGE>   8
                                      -4-


renewals in connection therewith, (c) all copyrightable works, all copyrights,
and all applications, registrations, and renewals in connection therewith, (d)
all trade secrets and confidential business information (including ideas,
research and development, know-how, formulas, compositions, manufacturing and
production processes and techniques, technical data, designs, drawings,
specifications, customer and supplier lists, pricing and cost information, and
business and marketing plans and proposals), (e) all computer software
(including related licences, technical documentation and domain names), (f) all
other proprietary rights, and (g) all copies and tangible embodiments thereof
(in whatever form or medium).

         "IRC" means Research Consultants (International) Limited (Company No:
02348938).

         "KENDLE" has the meaning set forth in the preface above.

         "KENDLE MATERIAL ADVERSE CHANGE" has the meaning set forth in
ss.7(b)(v) below.

         "KNOWLEDGE" means knowledge after reasonable enquiries by the Sellers
including where relevant reasonable enquiry of the accountants, solicitors, tax
advisers and insurance brokers who act for the TARGET and/or the Subsidiaries
and that each of the Sellers has used all reasonable endeavours to ensure that
all information given, referred to or reflected in that statement is accurate in
all material respects.

         "LIABILITIES" means any liability (whether known or unknown, whether
asserted or unasserted, whether absolute or contingent, whether accrued or
unaccrued, whether liquidated or unliquidated, and whether due or to become
due), including (without limitation) any liability for Taxes.

         "MANAGEMENT ACCOUNTS" has the meaning set forth in ss.4(g) below.

         "MARKET VALUE" means with respect to any Parent Shares, the average
closing bid price for shares of Parent common stock on NASDAQ during the twenty
Trading Days prior to either the date that a disputed claim under the Escrow
Agreement is finally determined or, if such claim is not disputed, the date of
release of such Parent Shares.

         "MOST RECENT BALANCE SHEET" means the balance sheet contained within
the Management Accounts.

         "MOST RECENT FINANCIAL MONTH END" has the meaning set forth in ss.4(g)
below.

         "MOST RECENT FINANCIAL YEAR END" has the meaning set forth in ss.4(g)
below.

         "NASDAQ" means the National Market System of the National Association
of Securities Dealers, Inc.



<PAGE>   9

                                      -5-

         "ORDINARY COURSE OF BUSINESS" means the ordinary course of business
consistent with past custom and practice (including with respect to quantity and
frequency).

         "PARENT" has the meaning set forth in the preface above.

         "PARENT SHARES" has the meaning set forth in ss.2(b) below.

         "PARTIES" means collectively Kendle and the Sellers.

         "PERMITS" has the meaning set forth in Section 4(c).

         "PENSION SCHEMES" means collectively (a) the Save & Prosper Scheme, (b)
the medical benefits scheme known as Private Patients Plans Group No. C56321,
(c) the Death in Service Scheme (Policy No RGLP00863212) and (d) the Long Term
Disability Insurance Scheme (Policy No 910389) all as currently operated by IRC.

         "PERSON" means an individual, a partnership, a corporation, a limited
liability company, an association, a joint stock company, a trust, a joint
venture, an unincorporated organisation, or a governmental entity (or any
department, agency, or political subdivision thereof).

         "PERSONAL PENSION SCHEME" means any personal pension scheme as defined
in section 1 of Pension Schemes Act 1993.

         "PREMISES" means the land and premises particulars of which are set out
in Schedule 2 (and includes any part thereof and all buildings, structures and
works on such premises).

         "PURCHASE PRICE" has the meaning set forth in ss.2(b) below.

         "RELEASE" has the meaning set forth in ss.7(a)(viii) below.

         "RELEVANT EMPLOYEE" means any past or present employee of TARGET and
its Subsidiaries.

         "SAVE & PROSPER SCHEME" means the Save & Prosper Personal Retirement
Account (Centralised Occupational Money Purchase Pension Scheme) established by
a Declaration of Trust dated 2 January 1975, but only to the extent that the
Employees and TARGET and its Subsidiaries participate in the scheme.

         "SEC" has the meaning set forth in ss.3(b)(v) below.



<PAGE>   10
                                      -6-


         "SECURITIES ACT" means the US Securities Act of 1933, as amended.

         "SECURITIES EXCHANGE ACT" means the US Securities Exchange Act of 1934,
as amended.

         "SECURITY INTEREST" means any mortgage, pledge, lien, encumbrance,
charge, assignment, hypothecation, security interest (including any created by
law), title retention or other security agreement or arrangement, other than (a)
mechanic's, materialmen's, and similar liens, (b) liens for Taxes not yet due
and payable or for Taxes that the taxpayer is contesting in good faith through
appropriate proceedings, (c) purchase money liens and liens securing rental
payments under capital lease arrangements, and (d) other liens arising in the
Ordinary Course of Business and not incurred in connection with the borrowing of
money.

         "SELLER" has the meaning set forth in the preface above.

         "SELLERS' SOLICITORS" means Hewitson Becke & Shaw of Shakespeare House,
42 Newmarket Road, Cambridge, CB5 8EP.

         "STERLING" and "(Pound)" shall mean the lawful currency for the time
being of the United Kingdom.

         "SUBSIDIARY" means (a) when used to determine the relationship between
a company incorporated in England and another Person, any "subsidiary" and
"subsidiary undertaking" as defined in the Companies Act 1989, Sections 144 and
21 and Schedule 9 respectively, and (b) when used to determine the relationship
between a company not incorporated in England to another Person, any corporation
with respect to which a specified Person (or a Subsidiary thereof) owns a
majority of the common stock (or similar interests) or has the power to vote or
direct the voting of sufficient securities to elect a majority of the directors.

         "TARGET" has the meaning set forth in the first recital above.

         "TARGET MATERIAL ADVERSE CHANGE" means a material adverse change in the
business, assets, liabilities, income, financial condition, operations, results
of operations or business prospects of TARGET and its Subsidiaries.

         "TARGET SHARE" means any of the ordinary shares of (pound)1.00 each in
the capital of TARGET.

         "TAXES" means (i) all forms of tax duties imposts and levies in the
nature of tax whenever created or imposed and whether of the United Kingdom or
elsewhere including (without limitation) corporation tax advance corporation tax
income tax (including income tax or amounts equivalent to income tax required to
be deducted or withheld from or accounted for in respect of


<PAGE>   11

                                      -7-



any payment) capital gains tax any payment under section 601(2) ICTA 1988
inheritance tax value added tax landfill tax stamp duty stamp duty reserve tax
vehicle duty customs & excise duties national insurance social security or
similar contributions and any other taxes levies duties charges imposts or
withholdings similar to corresponding with or replaced by any of the foregoing;
and (ii) all penalties fines charges surcharges and interest in relation to any
tax within subclause (i) above or to any return or information required to be
provided for the purposes of any such tax.

         "TAXES ACT 1988" means Income and Corporation Taxes Act 1988.

         "TAX DEED" means the deed in the form of Exhibit 1 hereto.

         "TAX LEGISLATION" means any statute, enactment, law or regulation
providing for the imposition of Taxes.

         "TAX LIABILITY" means a liability to make an actual payment of, or of
an amount in respect of, Tax whether or not such liability is also or
alternatively a liability of or chargeable against or attributable to, any other
person and whether or not TARGET or any of its Subsidiaries shall or may have a
right of recovery or reimbursement against any other person.

         "TAX RETURN" means any return, declaration, report, claim for refund,
or information return or statement relating to Taxes, including any schedule or
attachment thereto, and including any amendment thereof.

         "TCGA 1992" means the Taxation of Chargeable Gains Act 1992.

         "THIRD PARTY CLAIM" has the meaning set forth in ss.8(d) below.

         "TRADING DAY" means those days on which NASDAQ is open for trading.

         "UK GAAP" means United Kingdom generally accepted accounting
principles, as in effect from time to time.

         "US GAAP" means United States generally accepted accounting principles,
as in effect from time to time.

         "US" or "UNITED STATES" means the United States of America.

         "VATA 1994" means the Value Added Tax Act 1994.

         2.       PURCHASE AND SALE OF TARGET SHARES.


<PAGE>   12

                                      -8-



                  (a)      BASIC TRANSACTION. On and subject to the terms and
conditions of this Agreement, Kendle agrees to purchase from each of the Sellers
(relying inter alia, as the Sellers hereby acknowledge, on the representations,
warranties, undertakings and indemnities of the Sellers (or any of them)
referred to or contained in this Agreement and/or the Tax Deed), and each of the
Sellers agrees to sell to Kendle, all of his or her TARGET Shares for the
consideration specified below in this ss.2.

                  (b)      PURCHASE PRICE. At the Closing:

                           (i)      Kendle shall pay the Sellers a purchase
         price of Three Million Seven Hundred Thousand Sterling
         ((pound)3,700,000.00) (THE "PURCHASE PRICE").

                           (ii)     Two Million Four Hundred Seventy-Nine
         Thousand Sterling ((pound)2,479,000.00) of the Purchase Price shall be
         paid in cash to the Sellers' Solicitors at the Closing (the "CASH
         CLOSING PAYMENT").

                           (iii)    The balance of the Purchase Price (One
         Million Two Hundred Twenty-One Thousand Sterling ((pound)1,221,000.00))
         shall be satisfied by the issue of 87,558 shares of common stock, no
         par value, of the Parent ("PARENT SHARES") to the Sellers as set forth
         on Schedule 1. Each Seller shall immediately deliver to The Fifth Third
         Bank as escrow agent under the Escrow Agreement (which shall be in the
         form of Exhibit 2(b) hereto) his/her Parent Shares accompanied by duly
         executed stock powers in favour of The Fifth Third Bank. The Fifth
         Third Bank shall hold the Parent Shares as escrow agent under the
         Escrow Agreement for the benefit of the Sellers.

                           (v)      The Purchase Price shall be subject to
         reduction from time to time as provided in ss.2(h) below.

                  (c)      THE CLOSING. The closing of the transactions
contemplated by this Agreement (the "CLOSING") shall take place at the offices
of the Sellers' Solicitors, commencing at 9:00 a.m., local time, on 5 January
1999, subject to the satisfaction or waiver of all conditions to the obligations
of the Parties to consummate the transactions contemplated hereby (other than
conditions with respect to actions the respective Parties will take at the
Closing itself), or such other date as Kendle and the Sellers may mutually
determine (the "CLOSING DATE").

                  (d)      DELIVERIES AT THE CLOSING. At the Closing, (i) the
Sellers will deliver to Kendle the various certificates, instruments and
documents referred to in ss.7(a) below, (ii) Kendle will deliver to the Sellers
the various certificates, instruments and documents referred to in ss.7(b)
below, (iii) each of the Sellers will deliver to Kendle share certificates
representing all of his or her TARGET Shares, accompanied by duly executed stock
transfer forms together with such


<PAGE>   13

                                      -9-

waivers or consents as Kendle may require to enable Kendle or its nominees to be
registered as holders of TARGET shares, (iv) Kendle will deliver to the Sellers'
Solicitors (and the Sellers' Solicitors are hereby authorised to receive it) the
Cash Closing Payment specified in ss.2(b) above and the payment of such
consideration to the Sellers' Solicitors shall constitute a good discharge to
Kendle and Kendle shall have no obligation as to the distribution or allocation
of such consideration between the Sellers, (v) Kendle will deliver to the
Sellers the Parent Shares, and (vi) the Sellers will deliver the Parent Shares
accompanied by duly executed stock powers to The Fifth Third Bank as escrow
agent in accordance with the terms of the Escrow Agreement.

                  (e)      PRE-EMPTION RIGHTS WAIVER. The Sellers waive all
rights of pre-emption (if any) over TARGET Shares to which they may be entitled
under the Articles of Association of TARGET, or otherwise, in relation to the
sale and purchase of TARGET Shares pursuant to this Agreement.

                  (f)      TITLE TO THE TARGET SHARES. Title to and beneficial
ownership of the TARGET Shares shall pass at Closing and the TARGET Shares shall
be sold and purchased together with all rights and benefits attached or accruing
to them at Closing (including the beneficial ownership right to receive all
dividends, distributions or any return of capital declared, paid or made by
TARGET on or after Closing).

                  (g)      PURCHASE OF ALL TARGET SHARES. Kendle shall not be
obliged to complete the purchase of any of the TARGET Shares unless the purchase
of all the TARGET Shares is completed simultaneously.

                  (h)      REDUCTION OF PURCHASE PRICE.

                           (i)      The Purchase Price shall be reduced on each
         occurrence of the following events:

                                    (A)      If John Glasby either Resigns
                  without Good Reason or is Terminated for Cause (as each such
                  term is defined below) prior to the first anniversary of the
                  Closing Date, there shall be a reduction equal to thirty
                  percent (30%) of the Purchase Price, prior to the second
                  anniversary of the Closing Date, there shall be a reduction
                  equal to twenty percent (20%) of the Purchase Price, or prior
                  to the third anniversary of the Closing Date, there shall be a
                  reduction equal to ten percent (10%) of the Purchase Price;
                  and/or

                                    (B)      If Gillian Gregory either Resigns
                  without Good Reason or is Terminated for Cause (as each such
                  term is defined below) prior to the first anniversary of the
                  Closing Date, there shall be a reduction equal to thirty
                  percent (30%) of the Purchase Price, prior to the second
                  anniversary of the Closing Date,


<PAGE>   14
                                      -10-


                  there shall be a reduction equal to twenty percent (20%) of
                  the Purchase Price, or prior to the third anniversary of the
                  Closing Date, there shall be a reduction equal to ten percent
                  (10%) of the Purchase Price; and/or

                                    (C)      If Peter Nightingale either Resigns
                  without Good Reason or is Terminated for Cause (as each such
                  term is defined below) prior to the first anniversary of the
                  Closing Date, there shall be a reduction equal to fifteen
                  percent (15%) of the Purchase Price, prior to the second
                  anniversary of the Closing Date, there shall be a reduction
                  equal to ten percent (10%) of the Purchase Price, or prior to
                  the third anniversary of the Closing Date, there shall be a
                  reduction equal to five percent (5%) of the Purchase Price.

                           (ii)     For purposes of this ss.2(h) the terms
         "Resigns without Good Reason" and "Terminated for Cause" shall have the
         meanings as applied with respect to one of the individuals referred to
         in paragraphs (A), (B) and (C) above, given in the Employment Agreement
         between such individual and as such agreement is in effect on and from
         the Closing Date, and without regard to whether such agreement is
         amended or terminated in the future, unless Kendle and the Sellers
         shall specifically agree in writing that any such amendment or
         termination shall have the effect of amending this ss.2(h).

                           (iii)    The Purchase Price reductions required by
         this ss.2(h) shall be calculated on the full amount of the Purchase
         Price paid at Closing, and without regard to any prior or concurrent
         Purchase Price reduction taken pursuant to this ss.2(h) or pursuant to
         any other provision of this Agreement.

                           (iv)     On the effective date of a Termination for
         Cause or a Resignation without Good Reason (a "REDUCTION DATE") causing
         a Purchase Price reduction pursuant to this ss.2(h), each of the
         Sellers shall become liable to pay to Kendle their respective pro rata
         portions (based on the allocation percentages of the Purchase Price as
         set out on Schedule 1 hereto) of such Purchase Price reduction, and
         Kendle shall be entitled to receive each such amount within ten (10)
         days after the relevant Reduction Date, with interest thereon at the
         rate of ten percent (10%) per annum from the Reduction Date to the date
         of actual payment if such payment is not made in full by such date.

                           (v)      If there are assets held under the Escrow
         Agreement against which there is no claim pending at the time the
         Sellers become obligated to refund a portion of the Purchase Price
         under this ss.2(h), Kendle shall be obligated and have the right to
         receive from the escrow available cash or other assets to satisfy the
         obligations of the Sellers to repay such portion of the Purchase Price,
         but if the escrow is exhausted or unavailable for whatever reason,
         Kendle shall have the right to receive payment directly from the
         Sellers.


<PAGE>   15

                                      -11-


                           (vi)     Each of the events described in paragraph
         (i) above are independent of each other, and the refund of a portion of
         the Purchase Price in connection with termination of employment of one
         of the Sellers shall not relieve the Sellers from any obligation to
         make a further refund of the Purchase Price if required by this
         ss.2(h). In addition, the termination of employment of a Seller shall
         not relieve such Seller of his/her joint and several obligations
         hereunder in the event of a later termination of employment by another
         Seller which triggers a Purchase Price reduction in accordance with the
         terms hereof. (vii) The liability of the Sellers under this ss.2(h)
         shall in any event be subject to the limitations specified in
         ss.8(i)(ii) and ss.8(i)(iii).

         3.       REPRESENTATIONS AND WARRANTIES CONCERNING THE TRANSACTION.

                  (a)      REPRESENTATIONS AND WARRANTIES OF THE SELLERS. Each
of the Sellers represents and warrants to Kendle that the statements contained
in this ss.3(a) are correct and complete as of the date of this Agreement and
will be correct and complete as of the Closing Date (as though made then and as
though the Closing Date were substituted for the date of this Agreement
throughout this ss.3(a)) with respect to himself, herself or itself (but not
with respect to any other Seller). The statements made in ss.3(a) shall not in
any respect be extinguished or affected by the Closing.

                           (i)      AUTHORISATION OF TRANSACTION. Such Seller
         has full power and authority to execute and deliver this Agreement and
         to perform his or her obligations hereunder. This Agreement constitutes
         the valid and legally binding obligation of such Seller, enforceable in
         accordance with its terms and conditions. Such Seller need not give any
         notice to, make any filing with, or obtain any authorisation, consent,
         or approval of any government or governmental agency in order to
         consummate the transactions contemplated by this Agreement.

                           (ii)     NONCONTRAVENTION. Neither the execution and
         the delivery of this Agreement, nor the consummation of the
         transactions contemplated hereby, will (A) violate any constitution,
         statute, regulation, rule, injunction, judgment, order, decree, ruling,
         charge, or other restriction of any government, governmental agency, or
         court to which such Seller is subject (B) conflict with, result in a
         breach of, constitute a default under, result in the acceleration of,
         create in any party the right to accelerate, terminate, modify, or
         cancel, or require any notice under any agreement, contract, lease,
         license, instrument, or other arrangement to which such Seller is a
         party or by which he or she is bound or to which any of his assets is
         subject.



<PAGE>   16

                                      -12-

                           (iii)    BROKERS' FEES. Such Seller has no Liability
         or obligation to pay any fees or commissions to any broker, finder, or
         agent with respect to the transactions contemplated by this Agreement
         for which Kendle, TARGET or any of its Subsidiaries could become liable
         or obligated.

                           (iv)     INVESTMENT REPRESENTATIONS. With respect to
         the Parent Shares issued to and acquired by the Sellers hereunder:

                                    (A)      The Seller is not a US Person (as
                  defined in Regulation S promulgated under the Securities Act
                  ("REGULATION S")) and has signed this Agreement outside the
                  United States.

                                    (B)      The Seller understands and
                  acknowledges that (i) the Parent Shares have not been
                  registered under the Securities Act and may not be offered or
                  sold in the United States or to, or for the account or benefit
                  of, any US Person unless such securities are registered under
                  the Securities Act or such offer or sale is made pursuant to
                  an exemption from the registration requirements of the
                  Securities Act and (ii) the Parent Shares are being
                  distributed by the Parent pursuant to the terms of Regulation
                  S, which permits securities to be sold to non-US Persons in
                  "offshore transactions" (as defined in Regulation S), subject
                  to certain terms and conditions.

                                    (C)      The Seller acknowledges that for a
                  period of one year following the Closing Date (the "RESTRICTED
                  PERIOD"), the Seller shall not (i) engage in any activity for
                  the purpose of, or which may reasonably be expected to have
                  the effect of, conditioning the market in the United States
                  for the Parent Shares or (ii) unless an exemption from the
                  registration requirements of the Securities Act is available,
                  offer, sell or transfer the Parent Shares in the United States
                  or to, or for the account or benefit of, a US Person. The
                  Seller understands that the Parent Shares or any interest
                  therein are only transferable on the books and records of the
                  transfer agent and registrar of the Parent. The Seller further
                  understands that such transfer agent and registrar will not
                  register any transfer of the Parent Shares during the
                  Restricted Period which the Parent reasonably believes
                  violates the restrictions set forth in this paragraph (C), and
                  that the Parent acting in good faith may place stop transfer
                  orders with its transfer agent with respect to certificates
                  representing Parent Shares to reflect the restrictions set
                  forth in this paragraph (C).

                                    (D)      Any proposed offer, sale or
                  transfer during the Restricted Period of any of the Parent
                  Shares shall be subject to the condition that the Seller must
                  deliver to the Parent (i) a written certification that neither
                  record nor 


<PAGE>   17

                                      -13-



                  beneficial ownership of the Parent Shares has been offered or
                  sold in the United States or to, or for the account or benefit
                  of, any US Person, (ii) a written certification of the
                  proposed transferee that such transferee (or any account for
                  which such transferee is acquiring such Parent Shares) is not
                  a US Person, that such transferee is acquiring such Parent
                  Shares for such transferee's own account (or an account over
                  which he or she has investment discretion), and that such
                  transferee is knowledgeable of an agrees to be bound by the
                  restrictions on re-sale set forth in this section and
                  Regulation S during the Restricted Period, and (iii) a written
                  opinion of United States counsel, in form and substance
                  reasonable satisfactory to the Parent, to the effect that the
                  offer, sale and transfer of such Parent Shares are exempt from
                  registration under the Securities Act.

                                    (E)      The Seller agrees that for the
                  duration of the Restricted Period and until such time
                  thereafter as the Parent shall have received (if required by
                  it) a written opinion of United States counsel, in form and
                  substance reasonably satisfactory to the Parent, to the effect
                  that the Parent Shares are no longer "restricted securities"
                  within the meaning of Rule 144(a)(3) of the Securities Act,
                  the stock certificates representing the Parent Shares shall
                  bear the legend set forth below:

                                             The shares of Common Stock
                                             represented by this certificate may
                                             not be offered, sold or transferred
                                             except in accordance with the
                                             provisions of Regulations S (Rule
                                             901 through Rule 905, and the
                                             Preliminary Notes) under the
                                             Securities Act of 1933, as amended
                                             (the "Securities Act"), pursuant to
                                             registration under the Securities
                                             Act, or pursuant to an available
                                             exemption from registration.

                           (v)      TARGET SHARES. Such Seller is the registered
         and sole beneficial owner of the number of TARGET Shares set forth next
         to his or her name in Schedule 1 free and clear of any Encumbrances and
         with full title guarantee. Such Seller is not a party to any voting
         trust, proxy, or other agreement or understanding with respect to the
         voting of any share capital of TARGET.

                  (b)      REPRESENTATIONS AND WARRANTIES OF KENDLE. Kendle
represents and warrants to the Sellers that the statements contained in this
ss.3(b) are correct and complete as of the date of this Agreement and will be
correct and complete as of the Closing Date (as though made then and as though
the Closing Date were substituted for the date of this Agreement throughout this
ss.3(b)) , except as set forth in Schedule 3(b).



<PAGE>   18
                                      -14-

                           (i)      ORGANISATION OF KENDLE AND THE PARENT. Each
         of Kendle and the Parent is a corporation organised, validly existing
         and in good standing under the laws of the State of Ohio.

                           (ii)     AUTHORISATION OF TRANSACTION. Kendle has
         full power and authority (including full corporate power and authority)
         to execute and deliver this Agreement and to perform its obligations
         hereunder. This Agreement constitutes the valid and legally binding
         obligation of Kendle, enforceable in accordance with its terms and
         conditions. Assuming the truth and correctness of the Seller's
         statements in ss.3(a) of this Agreement, Kendle need not give any
         notice to, make any filing with, or obtain any authorisation, consent,
         or approval of any US government or governmental agency in order to
         consummate the transactions contemplated by this Agreement.

                           (iii)    NONCONTRAVENTION. Neither the execution and
         the delivery of this Agreement, nor the consummation of the
         transactions contemplated hereby, will (A) violate any constitution,
         statute, regulation, rule, injunction, judgment, order, decree, ruling,
         charge, or other restriction of any government, governmental agency, or
         court to which Kendle is subject or any provision of its charter or
         bylaws or (B) conflict with, result in a breach of, constitute a
         default under, result in the acceleration of, create in any party the
         right to accelerate, terminate, modify, or cancel, or require any
         notice under any material agreement, contract, lease, license,
         instrument, or other arrangement to which Kendle is a party or by which
         it is bound or to which any of its assets is subject.

                           (iv)     CAPITALISATION. The Parent's authorised
         equity securities consist of Fifteen Million (15,000,000) shares of
         common stock, no par value per share, and One Hundred Thousand
         (100,000) shares of undesignated preferred stock, no par value per
         share. As of October 30, 1998, Ten Million Nine Hundred Fifty-One
         Thousand Two Hundred Thirty-Two (10,951,232) shares of common stock
         were issued and outstanding and no shares of undesignated preferred
         stock were issued and outstanding. The Parent Shares to be received by
         the Sellers in connection with the transactions contemplated hereby
         will be duly authorised, validly issued, fully paid and non-assessable
         shares of common stock free and clear of any and all Encumbrances other
         than restrictions on transfer imposed by US federal and state
         securities laws and regulations.

                           (v)      SEC REPORTS. The Parent has timely filed
         with the US Securities and Exchange Commission ("SEC") all materials
         and documents required to be filed by it under the US Securities
         Exchange Act of 1934 (the "EXCHANGE ACT"). All the materials and
         documents filed with the SEC by the Parent since July 2, 1997,
         including its initial Registration Statement on Form S-1, are
         hereinafter referred to as the "Kendle SEC Reports." Kendle has
         previously provided to the Sellers a list of all the Kendle SEC Reports
         filed on or prior to the date of this Agreement. The Kendle SEC
         Reports, copies 


<PAGE>   19

                                      -15-



         of which have been delivered to the Sellers, are true and correct in
         all material respects, including the financial statements and other
         financial information contained therein, and do not omit to state any
         material fact necessary to make the statements in such Kendle SEC
         Reports, in light of the circumstances in which they were made, not
         misleading. The financial statements included in the Kendle SEC Reports
         fairly present in all material respects the financial condition and the
         results of operations, changes in stockholders' equity and cash flow of
         the Parent and its subsidiaries as at the respective dates of and for
         the periods referred to in such financial statements, all in accordance
         with US GAAP. Since the date of the most recent Kendle SEC Report,
         there has been no Kendle Material Adverse Change.

                           (vi)     BROKERS' FEES. Other than liability or
         obligation to Technomark Limited (which shall be the liability of
         Kendle and not of the Sellers), Kendle has no Liability or obligation
         to pay any fees or commissions to any broker, finder, or agent with
         respect to the transactions contemplated by this Agreement for which
         any Seller could become liable or obligated.

         4.       REPRESENTATIONS AND WARRANTIES CONCERNING TARGET AND ITS
SUBSIDIARIES. The Sellers, jointly and severally, represent and warrant to
Kendle that the statements contained in this ss.4 are correct and complete as of
the date of this Agreement, except as set forth in the Disclosure Schedule. All
references in this ss.4 to TARGET shall, unless the context requires otherwise,
be construed to include reference to its Subsidiaries.

                  (a)      ORGANISATION, QUALIFICATION, AND CORPORATE POWER.
TARGET is a private company limited by shares duly incorporated and registered
and validly existing under the laws of England and Wales. Each of TARGET and IRC
is duly authorised to conduct business under the laws of each jurisdiction in
which TARGET conducts business. Each of IRC and TARGET has full corporate power
and authority and all licenses, permits, and authorisations required from any
government, statutory or other regulatory body to carry on the businesses in
which it is engaged. Section 4(a) of the Disclosure Schedule lists the directors
and officers of TARGET and IRC. The Sellers have delivered to Kendle correct and
complete copies of the memoranda and articles of association of TARGET and IRC
(as amended to date). The statutory and other books containing among other
things the records of meetings of the shareholders, the board of directors and
any committees of the board of directors, the register of members and the
register of shares of TARGET and IRC are correct and complete. Neither TARGET
nor IRC is in default under or in violation of any provision of its memorandum
or articles of association.

                  (b)      CAPITALISATION. The authorised share capital of
TARGET consists of One Thousand (1,000) TARGET Shares and the issued share
capital of TARGET consists of One Hundred (100) TARGET Shares. All of the issued
TARGET Shares have been duly authorised, are validly issued, fully paid and are
held legally by the respective Sellers as set forth in ss.4(b) of the Disclosure
Schedule. Except as set forth in ss.4(b) of 



<PAGE>   20
                                      -16-


the Disclosure Schedule, there are no outstanding or authorised options,
warrants, purchase rights, subscription rights, conversion rights, exchange
rights, or other contracts or commitments that could require TARGET to issue,
sell, or otherwise cause to become outstanding any of its capital stock. There
are no outstanding or authorised stock appreciation, phantom stock, profit
participation, or similar rights with respect to TARGET. TARGET is not a party
to any voting trusts, proxies, or other agreements or understandings with
respect to the voting of the share capital of TARGET.

                  (c)      NONCONTRAVENTION. Neither the execution and the
delivery of this Agreement, nor the consummation of the transactions
contemplated hereby, will (i) violate any constitution, statute, regulation,
rule, injunction, judgment, order, decree, ruling, charge, or other restriction
of any government, governmental agency, or court to which TARGET is subject or
any provision of the charter or bylaws of TARGET, (ii) conflict with, result in
a breach of, constitute a default under, result in the acceleration of, create
in any party the right to accelerate, terminate, modify, or cancel, or require
any notice under any agreement, contract, lease, license instrument to which
TARGET is a party or by which it is bound or to which any of its assets is
subject, or (iii) result in the imposition of any Security Interest upon any of
its assets. TARGET does not need to give any notice to, make any filing with, or
obtain any authorisation, consent, or approval of any government or governmental
agency in order for the Parties to consummate the transactions contemplated by
this Agreement. TARGET and its Subsidiaries maintain, and ss.4(c) of the
Disclosure Schedule sets forth, all operating authorities, licenses, permits and
approvals and other authorisations from all governmental authorities
(collectively, the "PERMITS") as are necessary for the conduct of the business
of TARGET and its Subsidiaries. Except as expressly designated on ss.4(c) of the
Disclosure Schedule, none of TARGET's and its Subsidiaries' rights under each of
the Permits will terminate in connection with the change in control of TARGET at
Closing.

                  (d)      BROKERS' FEES. TARGET has no Liability or obligation
to pay any fees or commissions to any broker, finder, or agent with respect to
the transactions contemplated by this Agreement.

                  (e)      TITLE TO ASSETS. Excluding for the purposes of this
ss.4(e) the Premises and the Intellectual Property, TARGET and its Subsidiaries
have legal and beneficial ownership of the assets used by them, or shown on the
Most Recent Balance Sheet or acquired after the date thereof, free and clear of
all Security Interests, excepting only properties and assets disposed of in the
Ordinary Course of Business since the date of the Most Recent Balance Sheet and
certain other properties and assets involving in the aggregate more than Fifteen
Thousand Sterling ((pound)15,000.00) disposed of other than in the Ordinary
Course of Business as disclosed on the Disclosure Schedule.


<PAGE>   21

                                      -17-


                  (f)      SUBSIDIARIES. TARGET has one Subsidiary, namely IRC.
Section 4(f) of the Disclosure Schedule sets forth the name and jurisdiction of
incorporation or organisation of each Person in which TARGET has a direct or
indirect equity or ownership interest in any business and the number of (and
percentage of outstanding) shares or other interests owned by TARGET. All of
such shares or other interests are owned free and clear of any Encumbrances
other than restrictions on transfer imposed by applicable securities laws and
regulations and such shares or other interests are duly authorised, validly
issued and fully paid and do not subject the holder thereof to further liability
for capital contributions. Each corporation or other entity listed on ss.4(f) of
the Disclosure Schedule validly exists and has been duly incorporated or
organised under applicable law. TARGET is not party to any voting trusts,
proxies or other agreements or understandings with respect to the voting trusts,
proxies, or other agreements or understandings with respect to the voting or
capital stock of any such corporation or entity. The Sellers have delivered to
Kendle true, complete and correct (A) copies of the charter or other
organisational documents of each corporation or other entity listed on ss.4(f)
of the Disclosure Schedule, and (B) copies of all material financial information
with respect to such corporations deemed by the Sellers in their reasonable
discretion to be material to the business of such corporations or other entities
in the possession of or under the control of the Sellers.

                  (g)      FINANCIAL STATEMENTS. Attached hereto as Exhibit 4(g)
are the following financial statements (collectively the "FINANCIAL
STATEMENTS"): (i) audited consolidated and individual financial statements
(including the profit and loss accounts, balance sheets and cash flow
statements) for TARGET and its Subsidiaries as of and for the financial year
ended 31 August 1998 (the "MOST RECENT FINANCIAL YEAR END"), including, in each
case, the notes thereto and the directors' report and auditors' report; and (ii)
unaudited management accounts of IRC (including the profit and loss accounts,
balance sheets and cash flow statements) as of and for the two (2) months ended
31 October 1998 (the "MOST RECENT FINANCIAL MONTH END"), (the "MANAGEMENT
ACCOUNTS"). The Financial Statements (including where applicable the notes
thereto) have been prepared in accordance with UK GAAP applied on a consistent
basis throughout the periods covered thereby, present fairly in all material
respects (and in the case of the Accounts give a true and fair view of) the
financial condition of TARGET and its Subsidiaries as of such dates and the
results of operations of TARGET and its Subsidiaries for such periods and are
consistent with the books and records of TARGET and its Subsidiaries; PROVIDED,
however, that the Management Accounts are subject to normal year-end adjustments
(which will not be material individually or in the aggregate) and do not include
any provision for corporation tax or depreciation.

                  (h)      EVENTS SUBSEQUENT TO MOST RECENT FINANCIAL YEAR END.
Except as set forth in ss.4(h) of the Disclosure Schedule, since 31 August 1998,
there has not been any TARGET Material Adverse Change. Without limiting the
generality of the foregoing, since that date:


<PAGE>   22

                                      -18-


                           (i)      neither TARGET nor any of its Subsidiaries
         has sold, leased, transferred, or assigned any of its assets, tangible
         or intangible, involving in the aggregate more than Fifteen Thousand
         Sterling ((pound)15,000.00) other than for a fair consideration in the
         Ordinary Course of Business;

                           (ii)     other than agreements and contracts with
         customers pursuant to which IRC will be entitled to be paid in excess
         of Fifty Thousand Sterling ((pound)50,000), TARGET has not entered into
         any agreement, contract, lease, or license (or series of related
         agreements, contracts, leases, and licenses) either involving more than
         Fifteen Thousand Sterling ((pound)15,000.00) or outside the Ordinary
         Course of Business;

                           (iii)    no party (including TARGET and its
         Subsidiaries) has terminated, materially modified, or cancelled any
         agreement, contract, lease, or license (or series of related
         agreements, contracts, leases, and licenses) involving more than
         Fifteen Thousand Sterling ((pound)15,000.00) to which TARGET or any of
         its Subsidiaries is a party or by which it is bound;

                           (iv)     neither TARGET nor any of its Subsidiaries
         has imposed or permitted to be imposed any Security Interest upon any
         of its assets, tangible or intangible;

                           (v)      neither TARGET nor any of its Subsidiaries
         has made any capital expenditure (or series of related capital
         expenditures) either involving more than Fifteen Thousand Sterling
         ((pound)15,000.00) or outside the Ordinary Course of Business;

                           (vi)     neither TARGET nor any of its Subsidiaries
         has made any capital investment in, any loan to, or any acquisition of
         the securities or assets of, any other Person (or series of related
         capital investments, loans, and acquisitions) either involving more
         than Fifteen Thousand Sterling ((pound)15,000.00) or outside the
         Ordinary Course of Business;

                           (vii)    TARGET has not issued any Share, bond, or
         other debt security or created, incurred, assumed, or guaranteed any
         indebtedness for borrowed money or capitalised lease obligation either
         involving more than Fifteen Thousand Sterling ((pound)15,000.00) singly
         or Fifteen Thousand Sterling ((pound)15,000.00) in the aggregate;

                           (viii)   neither TARGET nor any of its Subsidiaries
         has delayed or postponed the payment of accounts payable and other
         Liabilities outside the Ordinary Course of Business;


<PAGE>   23
                                      -19-

                           (ix)     neither TARGET nor any of its Subsidiaries
         has cancelled, compromised, waived, or released any right or claim (or
         series of related rights and claims) either involving more than Fifteen
         Thousand Sterling ((pound)15,000.00) or outside the Ordinary Course of
         Business;

                           (x)      neither TARGET nor any of its Subsidiaries
         has granted any license or sublicense of any rights under or with
         respect to any Intellectual Property;

                           (xi)     there has been no change made or authorised
         in the memoranda or articles of association or other constitutional
         documents of TARGET or any of its Subsidiaries;

                           (xii)    TARGET has not declared, set aside, or paid
         any dividend or made any distribution with respect to its share capital
         (whether in cash or in kind) or redeemed, purchased, or otherwise
         acquired any of its share capital;

                           (xiii)   neither TARGET nor any of its Subsidiaries
         has experienced any damage, destruction, or loss (whether or not
         covered by insurance) to its assets and property in excess of Fifteen
         Thousand Sterling ((pound)15,000.00);

                           (xiv)    neither TARGET nor any of its Subsidiaries
         has made any loan (that will remain outstanding on the Closing Date) to
         or with any of its directors, officers, and employees outside the
         Ordinary Course of Business;

                           (xv)     neither TARGET nor any of its Subsidiaries
         has entered into any employment contract or collective bargaining
         agreement, written or oral, or changed or modified remuneration and
         benefits payable under such contract or agreement;

                           (xvi)    neither TARGET nor any of its Subsidiaries
          has granted any increase in the base compensation of any of its
         directors, and employees outside the Ordinary Course of Business;

                           (xvii)   TARGET has not in any material respect
         adopted, amended, modified, or terminated any bonus, profit-sharing,
         incentive, severance, or other plan, contract, or commitment for the
         benefit of any of its directors, officers, and employees (or taken any
         such action with respect to the Pension Schemes);\

                           (xviii)  neither TARGET nor any of its Subsidiaries
         has made or pledged to make any charitable or other capital
         contribution outside the Ordinary Course of Business;


<PAGE>   24
                                      -20-

                           (xix)    to the Knowledge of the Sellers there has
         not been any other material occurrence, event or transaction outside
         the Ordinary Course of Business which is likely to result in a TARGET
         Material Adverse Change; and,

                           (xx)     neither TARGET nor any of its Subsidiaries
         has committed to any of the foregoing.

                  (i)      UNDISCLOSED LIABILITIES. Neither TARGET nor any of
its Subsidiaries has any Liability (nor is there any Basis for any present or
future action, suit, proceeding, hearing, investigation, charge, complaint,
claim, or demand against any of them giving rise to any Liability), that
individually or in the aggregate is material to the results of operations or the
financial or other condition of TARGET or any of its Subsidiaries except for (i)
Liabilities reflected or reserved against on the Most Recent Balance Sheet or
described on ss.4(i) of the Disclosure Schedule or in the notes to the
Management Accounts; or (ii) Liabilities which have arisen after the Most Recent
Financial Month End in the Ordinary Course of Business (none of which results
from, arises out of or was caused by any breach by TARGET or any of its
Subsidiaries of any contract or warranty, by any tort or infringement by TARGET
or any of its Subsidiaries or by any violation of law by TARGET or any of its
Subsidiaries).

                  (j)      LEGAL COMPLIANCE. TARGET has complied with all
applicable laws (including rules, regulations, codes, plans, injunctions,
judgments, orders, decrees, rulings, and charges thereunder) of European Union,
national, local and foreign governments (and all agencies thereof), except where
such failure to comply would not, individually or in the aggregate, have a
TARGET Material Adverse Effect; and to the Knowledge of the Sellers, no action,
suit, proceeding, hearing, investigation, charge, complaint, claim, demand, or
notice has been filed or commenced against any of them alleging any such failure
to comply.

                  (k)      TAX MATTERS.

                           (i)      Each of TARGET and its Subsidiaries is and
         always has been resident for Tax purposes only in the jurisdiction in
         which it is incorporated.

                           (ii)     TARGET and its Subsidiaries have filed all
         Tax Returns that they were required to file. All such Tax Returns were
         correct and complete in all respects. All Taxes payable by TARGET and
         its Subsidiaries (whether or not shown on any Tax Return) have been
         paid. Neither TARGET nor any of its Subsidiaries is currently the
         beneficiary of any extension of time within which to file any Tax
         Return. No claim has ever been made by an authority in a jurisdiction
         where TARGET or any of its Subsidiaries do not file Tax Returns that
         TARGET or any of its Subsidiaries is or may be subject to taxation by
         that jurisdiction. There are no Security Interests on any of the assets


<PAGE>   25

                                      -21-

         of TARGET or its Subsidiaries that arose in connection with any failure
         (or alleged failure) to pay any Tax.

                           (iii)    TARGET and its Subsidiaries have withheld
         and paid all Taxes required to have been withheld and paid in
         connection with amounts paid or owing to any employee, independent
         contractor, creditor, stockholder, or other third party.

                           (iv)     Full provision or reserve has been made in
         the Financial Statements for all Taxes liable to be assessed on TARGET
         and its Subsidiaries or for which TARGET or its Subsidiaries are
         accountable in respect of income, profits or gains earned, accrued or
         received on or before the Most Recent Financial Year End and proper
         provision has been made in the Financial Statements (other than the
         Management Accounts) for deferred Taxes calculated in accordance with
         UK GAAP.

                           (v)      No Seller or director (or employee
         responsible for Tax matters) of TARGET or its Subsidiaries expects any
         authority to assess any additional Taxes for any period for which Tax
         Returns have been filed. There is no dispute or claim concerning any
         Tax Liability of TARGET or its Subsidiaries either (A) claimed or
         raised by any authority in writing or (B) as to which any of the
         Sellers and the directors (and employees responsible for Tax matters)
         of TARGET or its Subsidiaries has Knowledge based upon personal contact
         with any agent of such authority. ss.4(k) of the Disclosure Schedule
         indicates those Tax Returns that have been disputed and/or investigated
         by any governmental authority since 8 December 1992 and those Tax
         Returns that currently are the subject of an investigation or
         proceeding by any governmental authority. The Sellers have delivered to
         Kendle correct and complete copies of all European Union, national,
         local, and foreign income Tax Returns, examination reports, and
         statements of deficiencies assessed against or agreed to by TARGET or
         any its Subsidiaries since August 31, 1992.

                           (vi)     neither TARGET nor any of its Subsidiaries
         has waived any statute of limitations in respect of outstanding Taxes
         or agreed to any extension of time with respect to any outstanding Tax
         assessment or deficiency.

                           (vii)    Section 4(k)(vii) of the Disclosure Schedule
         contains particulars of all arrangements and agreements relating to the
         transfer of tax refunds to which the TARGET or its Subsidiaries are or
         have been a party since 8 December 1992, and (A) all claims by TARGET
         and its Subsidiaries for the transfer of tax refunds were when made and
         are now valid and have been or will be allowed by way of discharging
         the liability of the recipient company to pay any corporation tax, (B)
         neither TARGET nor any of its Subsidiaries has made or is liable to
         make any payment under any such arrangement save in consideration for
         the transfer of tax refunds allowable to TARGET or any of its



<PAGE>   26

                                      -22-


         Subsidiaries by way of discharge from liability to corporation tax and
         mergers equivalent to the taxation for which TARGET or any of its
         Subsidiaries would have been liable would it not have been for the
         transfers, (C) TARGET and its Subsidiaries have received all payments
         due to them under any such arrangement or agreement or transfer of tax
         refunds made by it and no such payment is likely to be repaid, and (D)
         save in respect of this Agreement, there have not been in existence in
         relation to TARGET and its Subsidiaries any such arrangements as are
         referred to in Section 410 Taxes Act 1988.

                           (viii)   No distribution within the meaning of
         Sections 209, 210 and 212 Taxes Act 1988 has been made by the TARGET
         and its Subsidiaries except dividends shown in its audited accounts nor
         is the TARGET and its Subsidiaries bound to make any such distribution.

                           (ix)     No securities (within the meaning of Section
         254(l) Taxes Act 1988) issued by TARGET and its Subsidiaries and
         remaining in issue at the date hereof were issued in such circumstances
         that the interest payable thereon falls to be treated as a distribution
         under Section 209(2)(e)(iii) Taxes Act 1988.

                           (x)      TARGET and its Subsidiaries have not made or
         received any distribution which is an exempt distribution within
         Section 213 Taxes Act 1988.

                           (xi)     TARGET and its Subsidiaries have not
         received any capital distribution to which the provisions of Section
         189 TCGA 1992 could apply.

                           (xii)    TARGET and its Subsidiaries have not used
         any credit, relief or set off that may be disallowed pursuant to
         Section 237 Taxes Act 1988.

                           (xiii)   TARGET and its Subsidiaries have not issued
         any share capital, nor granted options or rights to any person which
         entitles that person to require the issue of any share capital to which
         the provision of Section 249 Taxes Act 1988 could apply.

                           (xiv)    TARGET and its Subsidiaries have not since 8
         October 1996 (A) treated as franked investment income any qualifying
         distribution received which would fall to be treated as if it were a
         foreign income dividend pursuant to the provisions of Schedule 7 of the
         Finance Act 1997; or (B) made any qualifying distribution which would
         fall to be treated as a foreign income dividend pursuant to the
         provisions of Schedule 7 of the Finance Act 1997.

                           (xv)     No tax authority in any jurisdiction in
         which TARGET and its Subsidiaries do not file Tax Returns has made or
         asserted a claim that TARGET (or any Seller) is subject to taxation in
         that jurisdiction based on the activities of TARGET.


<PAGE>   27

                                      -23-


                           (xvi)    TARGET and its Subsidiaries have (to the
         extent required by law) preserved and retained in its possession
         accurate records relating to its Tax affairs as is required by law
         including corporation tax, PAYE, National Insurance and VAT records and
         TARGET and its Subsidiaries has sufficient records relating to past
         events to calculate the profit, gain, loss, balance charge of balancing
         allowance (all for Tax purposes) which would arise on any disposal or
         on the realisation of any assets owned at the Most Recent Financial
         Year End or acquired since that date but before the Closing.

                           (xvii)   TARGET and its Subsidiaries have duly and
         punctually paid all Taxes to the extent that the same ought to have
         been paid and has not in the last three years paid or become liable to
         pay any penalty or interest charged by virtue of the provisions of any
         Tax Legislation.

                           (xviii)  None of the following Events has occurred
         since the Most Recent Financial Year End.

                                    (A)      a deemed (as opposed to an actual)
                  acquisition, disposal or supply of assets, goods, services or
                  business facilities;

                                    (B)      TARGET or any of its Subsidiaries
                  ceasing or being deemed to cease to be a member of any group
                  or associated with any other company for the purposes of any
                  Taxes;

                                    (C)      a disposal or supply of assets,
                  goods, services or businesses facilities by TARGET or any of
                  its Subsidiaries for a consideration which is treated for
                  purposes of Taxes as greater than the actual consideration;

                                    (D)      an acquisition or supply to TARGET
                  or any of its Subsidiaries of assets, goods, services or
                  business facilities for a consideration which is treated for
                  the purposes of Taxes as less than the actual consideration;

                                    (E)      a distribution within the meaning
                  given by Part VI Taxes Act 1988 (company distributions, tax
                  credits etc.) or within Section 418 Taxes Act 1988 (expenses
                  treated as distributions);

                                    (F)      an Event which results in TARGET or
                  any of its Subsidiaries being liable for Taxes for which it is
                  not primarily liable;


<PAGE>   28
                                      -24-


                                    (G)      an Event in respect of which a Tax
                  Liability arises as a result of a failure by TARGET or any of
                  its Subsidiaries to withhold, deduct or account for Taxes;

                                    (H)      an Event giving rise to a liability
                  under Part XVII Taxes Act 1988 (tax avoidance); or

                                    (I)      an Event giving rise to a balancing
                  charge.

                           (xix)    The amount of Taxes chargeable on TARGET and
         its Subsidiaries during any accounting period ending on or within three
         years before the Most Recent Financial Year End or in respect of the
         period from the Most Recent Financial Year End up to the Closing Date
         has not, to any material extent, depended or (as the case may be) will
         not depend on any concession, agreement or other formal or informal
         arrangement with any Tax Authority.

                           (xx)     TARGET and its Subsidiaries have not during
         the period of three years ending on the date of this Agreement relied
         on any formal or informal unpublished concession dispensation or
         practice (whether general or specific to TARGET and its Subsidiaries)
         which purports to modify or provide exemption from any obligation to
         make or submit any computation, notice or return to any Tax Authority.

                           (xxi)    Within the period of three years ending on
         the date of this Agreement none of TARGET, its Subsidiaries or their
         predecessors (within the meaning of Section 343 Taxes Act 1988) has
         discontinued any trade or business or made a major change in the nature
         of or conduct of a trade or business carried on by it and no change in
         ownership of TARGET or any of its Subsidiaries has taken place.

                           (xxii)   TARGET and its Subsidiaries are not and have
         not at any time been close investment holding companies in respect of
         any accounting period.

                           (xxiii)  TARGET and its Subsidiaries have not made
         any loan, advance or payment or given any consideration falling within
         Sections 419 to 420 or Section 422 Taxes Act 1988 (charges to tax in
         connection with loans) which has remained outstanding at any time since
         8 December 1992.

                           (xxiv)   TARGET and its Subsidiaries have not at any
         time since 8 December 1992 made any payment which falls to be treated
         as a distribution under Section 418 Taxes Act 1988 (distribution to
         include certain expenses of close companies).


<PAGE>   29
                                      -25-


                           (xxv)    TARGET and its Subsidiaries have made no
         transfer of value such as is specified in Section 94(1) of the
         Inheritance Tax Act 1984 (charge on participators) and there has been
         no variation in TARGET's share or loan capital or any of its
         Subsidiaries share or loan capital within Section 98 of that Act
         (effect of alterations of capital etc.).

                           (xxvi)   No liability to taxation or non-trading
         deficit would arise from the loan relationships to which TARGET or any
         of its Subsidiaries is party being repaid to the extent of the amounts
         shown in respect of such loan relationships in the books of TARGET of
         any of its Subsidiaries at the date hereof.

                           (xxvii)  The sum which would be allowed as a
         deduction from the consideration under Section 38 TCGA 1992
         (acquisition and disposal costs etc.) of each asset of TARGET and its
         Subsidiaries (other than trading stock) if disposed of on the date of
         this Agreement:

                                    (A)      would not be less than (in the case
                  of an asset held on the Most Recent Financial Year End) the
                  book value of that asset shown or included in the Accounts or
                  (in the case of an asset acquired since the Most Recent
                  Financial Year End) an amount equal to the consideration given
                  for its acquisition; and in particular

                                    (B)      would not be treated or deemed for
                  the purposes of Tax to have been reduced by reason of any
                  claim made under Sections 152 (roll-over relief), 153 (assets
                  only partly replaced) 165 (relief for gifts of business
                  assets) or 175 (group roll-over) TCGA 1992 or by reason of the
                  operation of Section 17 (disposals and acquisitions treated as
                  made at market value), or Sections 126 to 140 TCGA 1992
                  (re-organisation of share capital, conversion of securities
                  etc).

                           (xxviii) Since 8 December 1992, no transaction has
         been entered into by TARGET or any of its Subsidiaries to which the
         provisions of Section 18 (transactions between connected persons) TCGA
         1992 has been or could be applied.

                           (xxix)   TARGET does not own any depreciating asset
         in respect of which a heldover gain may accrue pursuant to sections
         154(2) and/or 175(3) TCGA 1992.

                           (xxx)    No balancing charge in respect of any
         capital allowances claimed or given would arise if any asset of TARGET
         and its Subsidiaries (or, where computations are made for capital
         allowances purposes for pools of assets, all the assets in that pool)
         were to be realised on the date hereof for a consideration equal to the
         amount of the book value thereof as shown or included in the Accounts
         (or, in the case of any 


<PAGE>   30

                                      -26-



         asset acquired since the Most Recent Financial Year End, for a
         consideration equal to the consideration given for the acquisition).

                           (xxxi)   To the Knowledge of the Sellers, all
         necessary conditions for the availability of all capital allowances
         claimed by TARGET and its Subsidiaries have at all material times been
         satisfied and remain satisfied.

                           (xxxii)  To the Knowledge of the Sellers no event has
         occurred in consequence of which TARGET or any of its Subsidiaries is
         or may be held liable to pay or bear any Tax which is primarily
         chargeable against or attributable to some person, firm or company
         other than TARGET and its Subsidiaries.

                           (xxxiii) TARGET and its Subsidiaries have duly paid
         all stamp duty for which they are or have been or may be made liable
         and without limitation:

                                    (A)      all documents in the enforcement of
                  which TARGET and its Subsidiaries are or may be interested
                  have been duly stamped; and

                                    (B)      there are no documents outside the
                  United Kingdom which if they were brought into the United
                  Kingdom would give rise to a liability to stamp duty payable
                  by TARGET or any of its Subsidiaries.

                           (xxxiv)  TARGET and its Subsidiaries have duly paid
         all stamp duty reserve tax for which they are or have become liable and
         TARGET and its Subsidiaries have not been party to any transfer of
         chargeable securities (within the meaning of Section 99 of the Finance
         Act 1986) in respect of which TARGET or any of its Subsidiaries could
         become liable to pay any stamp duty reserve tax.

                           (xxxv)   TARGET and its Subsidiaries are not liable
         to any penalty in respect of any stamp duty or stamp duty reserve tax
         nor to the Knowledge of the Sellers are there any circumstances or
         transactions in which TARGET and its Subsidiaries are or have been a
         party which may result in TARGET or any of its Subsidiaries becoming
         liable to such penalty.

                           (xxxvi)  TARGET and its Subsidiaries have not in the
         period of three years ending on the date of this Agreement been party
         to any non-arms length transaction, to which principles on which the
         case of Furniss v Dawson could be applied.

                           (xxxvii) TARGET and its Subsidiaries have not in the
         period of three years ending on the date of this Agreement been party
         to or otherwise involved in any


<PAGE>   31
                                      -27-


         scheme or arrangement the main purpose or one of the main purposes of
         which was to avoid any Taxes.

                           (xxxviii) TARGET and its Subsidiaries are each
         registered for VAT in the United Kingdom under schedule VATA 1994 and
         have not at any time in the last six years been treated as (nor applied
         to be) a member of a group of companies for VAT purposes.

                           (xxxix)   TARGET and its Subsidiaries are not
         registered (nor required to be registered) for local VAT or its
         equivalent in any country other than the United Kingdom.

                           (xl)      Each of TARGET and its Subsidiaries is a
         taxable person for VAT purposes, has complied with all the requirements
         of VATA 1994 and all applicable regulations and orders.

                           (xli)     TARGET and its Subsidiaries have not in the
         last three years been subject to any penalty or liability under any of
         Sections 60 to 63 (inclusive), 65 or 67 to 69 (inclusive) VATA 1994 and
         have not during such period been subject to any penalty or liability
         nor been given any penalty liability notice within Section 64 of that
         Act (repeated misdeclarations) nor been given any surcharge liability
         notice within section 59 or 59A of that Act nor been given any notice
         within section 66 of that Act nor been given a warning within section
         76(2) of that Act and TARGET and its Subsidiaries have not been
         required by HM Commissioners of Customs and Excise to give any
         security.

                           (xlii)   No circumstances exist whereby TARGET and
         its Subsidiaries would or might become liable for value added tax
         pursuant to the provisions of Sections 47 (agents etc.) or 48 (tax
         representatives) VATA 1994.

                           (xliii)  TARGET and its Subsidiaries have not made
         any exempt supplies in consequence of which they are or will be unable
         to obtain credit for all input tax paid by them during any value added
         tax quarter ending after the Most Recent Financial Year End.

                           (xliv)   TARGET and its Subsidiaries have not made
         and are not otherwise bound by any election made pursuant to paragraph
         2 of schedule 10 VATA 1994.

                           (xlv)    TARGET and its Subsidiaries have not been
         party to a transaction to which Article 5 of the Value Added Tax
         (Special Provisions) Order 1995 (transfer of business as a going
         concern) has (or has purported to have been) applied.


<PAGE>   32

                                      -28-


                           (xlvi)   No asset of TARGET and its Subsidiaries is a
         capital item, the input tax on which could be subject to adjustment in
         accordance with the provisions of Part XV of the Value Added Tax
         Regulations 1995.

                           (xlvii)  TARGET and its Subsidiaries have no interest
         in any new or uncompleted buildings or civil engineering works within
         in the meaning of Group 1 Schedule 9 VATA 1994.

                           (xlviii) TARGET and its Subsidiaries have not been
         engaged in any transaction which has resulted or could result in TARGET
         and its Subsidiaries being treated as making any supply to themselves
         for value added tax purposes.

                           (xlix)   All value added tax payable upon the
         importation of goods and all excise duties payable to HM Customs &
         Excise payable in respect of any assets (including trading stock)
         imported or owned by TARGET and its Subsidiaries have been paid in
         full.

                           (l)      TARGET and its Subsidiaries have not in the
         period of six years ending on the date of this Agreement surrendered or
         claimed nor is it obliged to surrender or claim any amount by way of
         group relief under the provisions of section 402 Taxes Act 1988
         (surrender or relief between members of groups and consortia) or any
         advance corporation tax under the provisions of section 240 Taxes Act
         1988 (set-off of company's surplus ACT against subsidiary's liability
         to corporation tax).

                           (li)     No tax is or may become payable by TARGET or
         its Subsidiaries pursuant to Section 190 TCGA 1992 (tax on one member
         or group recoverable from another member) in respect of any chargeable
         gain accruing prior to the Closing Date.

                           (lii)    TARGET and its Subsidiaries are not liable
         (and will not after the Closing Date become liable pursuant to
         arrangements entered into before the Closing Date) to make:

                                    (A)      any payment for group relief
                  (within the meaning of Section 402(6) Taxes Act 1988) or any
                  payment for advance corporation tax (as mentioned in Section
                  240(8) Taxes Act 1988) or any payment for a tax refund (as
                  mentioned in Section 102(7) Finance Act 1989); or

                                    (B)      any refund (in whole or in part) of
                  any such payment received by TARGET or its Subsidiaries before
                  the Closing Date,

         save (in each case) any payment or refund to another Group Company.


<PAGE>   33
                                      -29-

                           (liii)   TARGET and its Subsidiaries have not at any
         time within the period of six years ending with the date of this
         Agreement acquired any asset other than as trading stock from any other
         company which at the time of the acquisition was a member of the same
         group of companies as TARGET and its Subsidiaries (as defined in
         Section 170 TCGA 1992 (groups of companies: definitions)) and no member
         of any group of companies of which TARGET and its Subsidiaries are or
         have at any material time been the principal company (as defined in
         Section 170 TCGA 1992 (groups of companies: definitions)) has so
         acquired any asset.

                           (liv)    TARGET and its Subsidiaries have not in the
         last seven years ceased to be a member of a group of companies for the
         purposes of Section 178 or 179 TCGA 1992 (company ceasing to be member
         of a group).

                           (lv)     TARGET and its Subsidiaries have not carried
         out or participated in any depreciatory transaction relating to any
         shares of securities of a company which are in its beneficial
         ownership.

                           (lvi)    Section 4(k)(lxi) of the Disclosure Schedule
         contains particulars of all elections made by TARGET and its
         Subsidiaries under Section 247 Taxes Act 1988 which are still in force
         (dividends etc. paid by one member of a group to another).

                           (lvii)   TARGET and its Subsidiaries do not have and
         have not had at any time since 8 December 1992 any associated company
         within the meaning of section 13 Taxes Act 1988 other than another
         Group Company.

                           (lviii)  TARGET and its Subsidiaries have not in the
         last three years made any payment or incurred any liability to make any
         payment of a revenue nature other than in relation to expenditures for
         entertainment purposes which could be disallowed as a deduction in
         computing the taxable profits of TARGET and its Subsidiaries or as a
         charge on the income of TARGET and its Subsidiaries.

                           (lix)    To the Knowledge of the Sellers TARGET and
         its Subsidiaries are not and will not become liable to be assessed to
         inheritance tax as donor or donee of any gift or a transferor or
         transferee of value (actual or deemed) nor as a result of any
         disposition chargeable transfer or transfer of value (actual or deemed)
         made by or deemed not be made by any other person.

                           (lx)     There is no unsatisfied liability to capital
         transfer tax or inheritance tax attached or attributable to the assets
         of TARGET and its Subsidiaries or the shares of 


<PAGE>   34

                                      -30-


         TARGET and its Subsidiaries and neither such assets nor such shares are
         subject to an Inland Revenue charge.

                           (lxi)    To the Knowledge of the Sellers, no person
         has the power under Section 212 of the Inheritance Tax Act 1984 (powers
         to raise tax) to raise any capital transfer tax or inheritance tax by
         sale or mortgage of or by terminable charge on any of TARGET's and its
         Subsidiaries' assets or shares.

                           (lxii)   No transaction described in section 765 (1)
         Taxes Act 1988 (migration, etc of companies) has been carried out or
         proposed by or in relation to TARGET and its Subsidiaries.

                           (lxiii)  TARGET and its Subsidiaries do not have (in
         the period of three years ending on the date of this Agreement has not
         had) any branch, agent or permanent establishment (within the meaning
         of the OECDS Model Double Taxation Agreement) outside the United
         Kingdom.

                           (lxiv)   TARGET and its Subsidiaries do not have and
         have not in the last seven years had any interest in:

                                    (A)      a controlled foreign company within
                  the meaning of Section 747 Taxes Act 1988 (imputation of
                  chargeable profits and creditable tax of controlled foreign
                  companies); or

                                    (B)      a material interest in an offshore
                  fund within the meaning of Chapter V or Part XVII Taxes Act
                  1988.

                           (lxv)    TARGET and its Subsidiaries are not liable
         to be assessed to tax under Section 42A Taxes Act 1988 (non-residents
         and their representatives) and has not received any such assessment.

                           (lxvi)   Since 8 December 1992, TARGET and its
         Subsidiaries have not established (nor is it a participant in) any
         bonus, share option, profit related pay or other scheme or arrangement,
         whether or not approved by the Inland Revenue, for the benefit of its
         current or former officers or employees or any of them.

                  (l)      PROPERTY.

                           (i)      Schedule 2 sets forth a true and correct
         description of the particulars of all property owned by TARGET and its
         Subsidiaries. With respect to each such Premises:


<PAGE>   35

                                      -31-


                                    (A)      TARGET and its Subsidiaries are the
                  sole legal and beneficial owners of the Premises and are
                  entitled to and have good and marketable title and exclusive
                  occupation of such Premises; and

                                    (B)      TARGET and its Subsidiaries have
                  good and marketable title to the parcel of real property free
                  and clear of any mortgage or charge (whether legal or
                  equitable, fixed or floating), encumbrance, lease, sub-lease,
                  tenancy, licence or right of occupation, rent charge, and to
                  the Knowledge of the Sellers any exception, reservation,
                  easement, quasi-easement or privilege in favour of a third
                  party.

                           (ii)     ss.4(l)(ii) of the Disclosure Schedule lists
         all real property leased or subleased to any of TARGET and its
         Subsidiaries. The Sellers have delivered to Kendle correct and complete
         copies of the leases and subleases listed in ss.4(l)(ii) of the
         Disclosure Schedule (as amended to date). With respect to each lease
         and sublease listed in ss.4(l)(ii) of the Disclosure Schedule:

                                    (A)      to the Knowledge of the Sellers,
                  the lease or sublease is in full force and effect and will
                  continue to be in full force and effect on identical terms
                  following the consummation of the transactions contemplated
                  hereby;

                                    (B)      TARGET and its Subsidiaries have
                  not assigned, transferred, conveyed, mortgaged, deeded in
                  trust, or encumbered any interest in the leasehold or
                  subleasehold;

                                    (C)      to the Knowledge of the Sellers,
                  the owner of each facility leased or subleased to TARGET has
                  good and marketable title to the parcel of real property free
                  and clear of any Security Interest other than Security
                  Interests that do not materially impair TARGET's or its
                  Subsidiaries' use of such facility.

                           (iii)    TARGET and its Subsidiaries have not entered
         into positive covenants or personal obligations (whether in a
         conveyance, transfer or assignment to it or otherwise) neither does it
         have any personal rights under which it has any subsisting liability
         (whether actual or contingent).

                           (iv)     Any necessary or appropriate action to
         protect the interests of TARGET and its Subsidiaries has been taken
         under the Landlord and Tenant Act 1954 and in relation to rent review
         provisions in relation to each lease, sub-lease, tenancy or agreement
         for any of the same in respect of which the TARGET or its Subsidiaries
         is the landlord or the tenant thereunder and all appropriate time
         limits have been complied with and no rent reviews are outstanding at
         the date hereof or exercisable prior to the Closing.



<PAGE>   36

                                      -32-


                           (v)      Where the interest of the TARGET or its
         Subsidiaries in any of the Premises is leasehold, there is no right for
         the landlord to determine the lease except in the event of nonpayment
         of rent or other breach of covenant by the tenant.

                           (vi)     Except in relation to the Premises, TARGET
         and its Subsidiaries have no liabilities (actual or contingent) arising
         out of the conveyance, transfer, lease, tenancy, licence, agreement or
         other document relating to land or premises or an interest in land or
         premises, including, without limitations leasehold premises assigned or
         otherwise disposed of.

                           (vii)    Replies to enquiries given by Sellers'
         Solicitors to enquiries raised by Kendle's solicitors are true and
         accurate in all material respects.

                  (m)      INTELLECTUAL PROPERTY.

                           (i)      TARGET and its Subsidiaries own or have the
         right to use pursuant to license, sublicense, agreement, or permission
         all Intellectual Property that is material to the operation of the
         businesses of TARGET and its Subsidiaries as presently conducted.
         Except as set forth on ss.4(m) of the Disclosure Schedule, each such
         material item of Intellectual Property will be owned or available for
         use by TARGET and its Subsidiaries on identical terms and conditions
         immediately subsequent to the Closing hereunder.

                           (ii)     None of the Sellers and the directors (and
         employees with responsibility for Intellectual Property matters) of
         TARGET and its Subsidiaries have received any charge, complaint, claim,
         demand, or notice which is outstanding alleging any such interference,
         infringement, misappropriation, or violation (including any claim that
         any of TARGET and its Subsidiaries must license or refrain from using
         any Intellectual Property rights of any third party). To the Knowledge
         of any of the Sellers and the directors and officers (and employees
         with responsibility for Intellectual Property matters) of TARGET and
         its Subsidiaries, no third party has interfered with, infringed upon,
         misappropriated, or otherwise come into conflict with any Intellectual
         Property rights of any of TARGET and its Subsidiaries.

                           (iii)    No patent or registration has been issued to
         TARGET and its Subsidiaries with respect to any of its Intellectual
         Property, no pending patent application or application for registration
         has been made by TARGET and its Subsidiaries with respect to any of its
         Intellectual Property, and no license, agreement, or other permission
         has been granted by TARGET and its Subsidiaries to any third party with
         respect to any of its Intellectual Property (together with any
         exceptions). No trade name or unregistered 


<PAGE>   37

                                      -33-

         trademark is used by TARGET and its Subsidiaries in connection with any
         of its businesses.

                           (iv)     ss.4(m)(iv) of the Disclosure Schedule
         identifies each item of Intellectual Property that any third party owns
         and that TARGET and its Subsidiaries use pursuant to license,
         sublicense, agreement, or permission. The Sellers have delivered to
         Kendle correct and complete copies of all such licenses, sublicenses,
         agreements, and permissions (as amended to date). With respect to each
         item of Intellectual Property required to be identified in ss.4(m)(iv)
         of the Disclosure Schedule:

                                    (A)      to the Knowledge of the Sellers,
                  the license, sublicense, agreement, or permission covering the
                  item is in full force and effect and will continue to be in
                  full force and effect on identical terms following the
                  consummation of the transactions contemplated hereby
                  (including the assignments and assumptions referred to in ss.2
                  above);

                                    (B)      to the Knowledge of the Sellers, no
                  party to the license, sublicense, agreement, or permission is
                  in material breach or material default or has repudiated such
                  license, sublicense, agreement or permission, and no event has
                  occurred which with notice or lapse of time would constitute a
                  material breach or material default or permit termination,
                  modification, or acceleration thereunder;

                                    (C)      to the Knowledge of the Sellers no
                  action, suit, proceeding, hearing, investigation, charge,
                  complaint, claim, or demand is pending or is threatened which
                  challenges the legality, validity, or enforceability of the
                  underlying item of Intellectual Property; and

                                    (D)      TARGET and its Subsidiaries have
                  not granted any sublicense or similar right with respect to
                  the license, sublicense, agreement, or permission.

                           (v)      To the Knowledge of any of the Sellers and
         the directors and officers (and employees with responsibility for
         Intellectual Property matters) of TARGET and its Subsidiaries, TARGET
         and its Subsidiaries will not interfere with, infringe upon,
         misappropriate, or otherwise come into conflict with, any Intellectual
         Property rights of third parties as a result of the continued operation
         of its businesses as presently conducted.

                           (vi)     To the Knowledge of any of the Sellers, the
         technology of TARGET and its Subsidiaries which is material for the
         operation of their businesses is "Year 2000 compliant" in that it
         correctly performs all date-related operations (A) 


<PAGE>   38
                                      -34-

         without human intervention, other than original data entry of any date,
         (B) without regard to whether any date involved in the operation occurs
         in the twentieth or twenty-first centuries and (C) without regard to
         the system date at the time the calculation is performed.

                  (n)      TANGIBLE ASSETS. TARGET and its Subsidiaries own or
lease all facilities, machinery, equipment, and other tangible assets necessary
for the conduct of its businesses as presently conducted. Each such tangible
asset has been maintained in accordance with normal industry practice, is in a
reasonable state of operating condition and repair (subject to normal wear and
tear), and is suitable for the purposes for which it presently is used.

                  (o)      CONTRACTS.ss.4(o) of the Disclosure Schedule lists
                           the following contracts and other agreements to which
TARGET or any of its Subsidiaries is a party:

                           (i)      any agreement (or group of related
         agreements) for the lease of personal property (other than capitalised
         lease obligations) to or from any Person providing for lease payments
         in excess of Fifteen Thousand Sterling ((pound)15,000.00) per annum;

                           (ii)     other than agreements and contracts with
         customers, as to which Fifty Thousand Sterling ((pound)50,000.00) shall
         be the disclosure threshold for ss. 4(o) of the Disclosure Schedule,
         any agreement (or group of related agreements) for the purchase or sale
         of raw materials, commodities, supplies, products, or other personal
         property, or for the furnishing or receipt of services, the performance
         of which will extend over a period of more than one year, result in a
         material loss to TARGET, or involve consideration in excess of Fifteen
         Thousand Sterling ((pound)15,000.00);

                           (iii)    any agreement concerning a partnership or
         joint venture;

                           (iv)     any agreement (or group of related
         agreements) under which it has created, incurred, assumed, or
         guaranteed any indebtedness for borrowed money, or any capitalised
         lease obligation, in excess of Fifteen Thousand Sterling
         ((pound)15,000.00);

                           (v)      any agreement concerning confidentiality or
         noncompetition other than standard provisions in contracts with
         TARGET's customers;

                           (vi)     any agreement with any of the Sellers and
         their Affiliates (other than TARGET and its Affiliates);


<PAGE>   39

                                      -35-


                           (vii)    any profit sharing, stock option, stock
         purchase, phantom stock, stock appreciation, deferred compensation,
         severance, or other material plan or arrangement for the benefit of its
         current or former directors, officers, and employees;

                           (viii)   any collective bargaining agreement;

                           (ix)     any agreement for the employment of any
         individual on a full-time, part-time, consulting, or other basis
         providing annual compensation in excess of Fifteen Thousand Sterling
         ((pound)15,000.00) or providing severance benefits in excess of Fifteen
         Thousand Sterling ((pound)15,000.00);

                           (x)      any agreement under which it has advanced or
         loaned any amount to any of its directors, officers, and employees
         outside the Ordinary Course of Business;

                           (xi)     any agreement with customers and suppliers
         under which the consequences of a default or termination could be
         reasonably expected to result in a TARGET Material Adverse Change; or

                           (xii)    other than agreements or contracts with
         customers, any other agreement (or group of related agreements) the
         performance of which involves consideration in excess of Fifteen
         Thousand Seven Hundred Sterling ((pound)15,000.00).

The Sellers have delivered to Kendle a correct and complete copy of each written
agreement listed in ss.4(o) of the Disclosure Schedule (as amended to date) and
a written summary setting forth the terms and conditions of each oral agreement
referred to in ss.4(o) of the Disclosure Schedule. With respect to each such
agreement: (A) to the Knowledge of the Sellers, the agreement is in full force
and effect; (B) to the Knowledge of the Sellers, the agreement will continue to
be in full force and effect on identical terms following the consummation of the
transactions contemplated hereby; (C) to the Knowledge of the Sellers, no party
is in material breach or material default, and no event has occurred which with
notice or lapse of time would constitute a material breach or material default,
or permit termination, modification, or acceleration, under the agreement; and
(D) no party has repudiated any provision of the agreement. Except as listed on
ss.4(o) of the Disclosure Schedule, TARGET and its Subsidiaries are not parties
to any contract or agreement relating to provision by TARGET and its
Subsidiaries of services, with any applicable governmental authority.

                  (p)      BOOK DEBTS.

                           (i)      All book debts of TARGET and its
         Subsidiaries included in the Accounts are reflected properly on their
         books and records, are valid receivables subject to no setoffs or
         counterclaims, are current and collectible and will be collected in


<PAGE>   40

                                      -36-


         accordance with their terms at their recorded amounts other than book
         debts not exceeding (pound)11,000 in the aggregate.

                           (ii)     All book debts of TARGET and its
         Subsidiaries included in the Management Accounts for services provided
         through 30 November 1998 are reflected properly on their books and
         records, are valid receivables subject to no setoffs or counterclaims
         and are current. To the Knowledge of the Sellers, there is no
         impediment to the collectibility of such book debts.

                  (q)      POWERS OF ATTORNEY. There are no outstanding powers
of attorney executed on behalf of TARGET or its Subsidiaries.

                  (r)      INSURANCE. ss.4(r) of the Disclosure Schedule sets
forth the following information with respect to each insurance policy (including
policies providing property, casualty, liability, and workers' compensation
coverage and bond and surety arrangements) to which TARGET or any of its
Subsidiaries is a party, a named insured, or otherwise the beneficiary of
coverage:

                           (i)      the name, address, and telephone number of
         the agent;

                           (ii)     the name of the insurer, the name of the
         policyholder, and the name of each covered insured;

                           (iii)    the policy number and the period of
         coverage;

                           (iv)     the scope (including an indication of
         whether the coverage was on a claims made, occurrence, or other basis)
         and amount (including a description of how deductibles and ceilings are
         calculated and operate) of coverage; and

                           (v)      a description of any retroactive premium
         adjustments or other loss-sharing arrangements.

With respect to each such insurance policy: (A) to the Knowledge of the Sellers,
the policy is in full force and effect; (B) to the Knowledge of the Sellers, the
policy will continue to be in full force and effect on identical terms following
the consummation of the transactions contemplated hereby; (C) to the Knowledge
of the Sellers, neither TARGET and its Subsidiaries nor any other party to the
policy is in material breach or material default (including with respect to the
payment of premiums or the giving of notices), and no event has occurred which,
with notice or the lapse of time, would constitute such a material breach or
material default, or permit termination, modification, or acceleration, under
the policy; and (D) no party to the policy has repudiated any provision thereof.
TARGET and its Subsidiaries have been covered during the past three (3)


<PAGE>   41
                                      -37-

years by insurance in scope and amount customary and reasonable for the
businesses in which it has engaged during the aforementioned period. There are
no self-insurance arrangements affecting TARGET and its Subsidiaries.

                  (s)      LITIGATION. Section 4(s) of the Disclosure Schedule
sets forth each instance in which TARGET or its Subsidiaries (i) is subject to
any outstanding injunction, judgment, order, decree, ruling, or charge or (ii)
is a party or, to the Knowledge of any of the Sellers and the directors of
TARGET and its Subsidiaries, is threatened to be made a party to any action,
suit, proceeding, hearing, or investigation of, in, or before any court or
quasi-judicial or administrative agency of any applicable jurisdiction or before
any arbitrator. None of the actions, suits, proceedings, hearings, and
investigations set forth in ss.4(s) of the Disclosure Schedule is likely, if
adversely determined, to result in any TARGET Material Adverse Change. None of
the Sellers and the directors and officers (and employees with responsibility
for litigation matters) of TARGET and its Subsidiaries has any reason to believe
that any such action, suit, proceeding, hearing, or investigation may be brought
or threatened against any of TARGET or any of its Subsidiaries.

                  (t)      EMPLOYEES AND PENSION SCHEMES.

                           (i)      The individuals, details of whom are set
         forth in ss.4(t)(i) of the Disclosure Schedule (the "EMPLOYEES") are
         all employed by TARGET and its Subsidiaries at the date of this
         Agreement. There are no other individuals employed by the TARGET and
         its Subsidiaries at the date of this Agreement.

                           (ii)     The particulars shown in ss.4(t)(i) of the
         Disclosure Schedule show true and complete details of the names, ages
         and lengths of continuous service of all of the Employees and by
         reference to each of the Employees remuneration payable and other
         benefits provided by TARGET or any of its Subsidiaries or which TARGET
         or its Subsidiaries is bound to provide (whether now or in the future)
         to each category of the Employees at Closing or any Person connected
         with any such Person and (without limiting the generality of the
         foregoing) include particulars of all the material terms of profit
         sharing, incentive, bonus, commission arrangements and any other
         benefit to which any such category of the Employees is entitled or
         which is regularly provided or made available to them (including
         details of their notice period and their entitlement to holiday).

                           (iii)    All Employees (other than those set forth on
         ss.4(t)(iii)) have entered into and are subject to the terms of
         employment contracts in substantially similar form to the employment
         agreement attached hereto as Exhibit 7(t)(iii).


<PAGE>   42
                                      -38-

                           (iv)     There are no subsisting contracts for the
         provision by any person of any consultancy services to TARGET and its
         Subsidiaries.

                           (v)      None of the Employees has given notice
         terminating his contract of employment.

                           (vi)     None of the Employees is under notice of
         dismissal or has any outstanding dispute with TARGET or any of its
         Subsidiaries in connection with or arising from his employment nor is
         there any liability outstanding to such persons except for remuneration
         or other benefits accruing due and no such remuneration or other
         benefit which has fallen due for payment has not been paid.

                           (vii)    During the period of six months ending with
         the execution of this Agreement neither TARGET nor any of its
         Subsidiaries has directly or indirectly terminated the employment of
         any person employed in or by TARGET or its Subsidiaries.

                           (viii)   None of the Employees belongs or has
         belonged at any material time to an independent trade union recognised
         by the TARGET and its Subsidiaries and no such trade union is
         recognised by TARGET and its Subsidiaries.

                           (ix)     There are no employee representatives
         representing all or any of the Employees.

                           (x)      The TARGET and its Subsidiaries has complied
         with all of its statutory obligations to inform and consult appropriate
         representatives as required by law.

                           (xi)     There is no plan, scheme, commitment,
         policy, custom or practice (whether legally binding or not) relating to
         redundancy or termination of employment affecting any of the Employees
         more generous than the statutory redundancy requirements.

                           (xii)    All Pension Schemes comply in all material
         respects with all relevant statutes, regulations and other laws and all
         necessary consents in relation to such plans have been obtained and all
         governmental filings in relation to such plans have been made.

                           (xiii)   There are no loans owed by any of the
         Employees to the TARGET and its Subsidiaries.


<PAGE>   43

                                      -39-


                           (xiv)    Except for the Pension Schemes, neither
         TARGET nor any of its Subsidiaries is under any present or future
         liability to pay to any of the Employees or to any other person who has
         been in any manner connected with TARGET and its Subsidiaries any
         pension, superannuation allowance, death benefit, retirement gratuity
         or like benefit or to contribute to any life assurance scheme, medical
         insurance scheme, or permanent health scheme and TARGET and its
         Subsidiaries have not made any such payments or contributions on a
         voluntary basis nor is it proposing to do so.

                           (xv)     There is no:

                                    (A)      outstanding or threatened claim by
                  any person who is now or has been an employee of the TARGET
                  and its Subsidiaries or any dispute outstanding with any of
                  the said persons or with any unions or any other body
                  representing all or any of them in relation to their
                  employment by the TARGET and its Subsidiaries or, to the
                  Knowledge of the Sellers, of any circumstances likely to give
                  rise to any such dispute;

                                    (B)      industrial action involving any
                  employee, whether official or unofficial, currently occurring
                  or threatened; or

                                    (C)      industrial relations matter which
                  has been referred to ACAS or any similar governmental agency
                  in the applicable jurisdiction for advice, conciliation or
                  arbitration.

                           (xvi)    Save for the Pension Schemes, neither TARGET
         nor any of its Subsidiaries is a party to or participates in or
         contributes to any scheme, agreement or arrangement (whether legally
         enforceable or not) for the provision of any pension, retirement,
         death, incapacity, sickness, disability, accident or other like
         benefits (including the payment after cessation of employment with
         TARGET and its Subsidiaries of medical expenses) for any Relevant
         Employee or for the widow, widower, child or dependent of any Relevant
         Employee. The Save & Prosper Scheme is a money purchase scheme (as
         defined in section 181(1) of the Pension Schemes Act 1993) and the
         benefits payable under this scheme whether immediate, prospective or
         contingent, are solely the benefits which can be provided by the funds
         available for each member of this scheme.

                           (xvii)   TARGET and its Subsidiaries have disclosed
         to Kendle:

                                    (A)      true and complete copies of the
                  following documents referable to the Pension Schemes:

                                           (1)      all deeds, rules and other
                                     governing documents;


<PAGE>   44

                                      -40-


                                           (2)      all announcements, booklets 
                                    and the like of current effect;

                                    (B)      details of all amendments (if any)
                  to the Pension Schemes which have been announced or are
                  proposed but which have not yet been formally made;

                                    (C)      details of all discretionary
                  increases (if any) to pensions in payment or in deferment
                  under the Pension Schemes which have been granted in the six
                  years prior to the date of this Agreement or which are under
                  consideration;

                                    (E)      details of all discretionary
                  practices (if any) which may have led any person to expect
                  additional benefits in a given set of circumstances (by way of
                  example, but without limitations, on retirement at the behest
                  of the TARGET and its Subsidiaries or in the event of
                  redundancy); and

                                    (F)      details of the rate at which and
                  basis upon which the TARGET and its Subsidiaries currently
                  contribute to the Pension Schemes and any personal pension
                  scheme (as defined in section 1 of the Pension Schemes Act
                  1993) of any Employee or any other person, and any change to
                  that rate and/or basis which is proposed or which is under
                  consideration.

                           (xviii)  Every person who has at any time had the
         right to join, or apply to join, the Pension Schemes his been properly
         advised of that right. No Relevant Employee has been excluded from
         membership of the Pension Schemes or from any of the benefits
         thereunder in contravention of Article 119 of the Treaty of Rome, the
         Pensions Act 1995 or other applicable laws or requirements or the
         provisions of the Pension Schemes or otherwise.

                           (xix)    None of the employees of TARGET and its
         Subsidiaries is to the Knowledge of the Sellers (A) applying for or
         about to apply for an ill health early retirement pension under the
         Pension Schemes, or (B) terminally ill. To the Knowledge of any of the
         Sellers, none of the Sellers has any medical condition or illness which
         would prevent such person from fulfilling all of such person's
         obligations under such person's respective Employment Agreement.

                           (xx)     No transfer value has been paid (directly or
         indirectly) to the Pension Schemes from another arrangement for any
         member of the Pension Schemes.





<PAGE>   45
                                      -41-


                           (xxi)    All benefits (other than any refund of
         members' contributions with interest where appropriate) payable under
         the Pension Schemes on the death of any person while in employment to
         which the Pension Schemes relate are insured fully under a policy with
         an insurance company of good repute and to the Knowledge of the Sellers
         there are no grounds on which that company might avoid liability under
         that policy.

                           (xxii)   Contributions to the Pension Schemes and to
         any Personal Pension Scheme in respect of the Employees which have
         fallen due for payment have been paid at the time they were due.
         Neither TARGET nor its Subsidiaries contribute to the Pension Schemes
         or to any Personal Pension Scheme over an above the contributions
         disclosed under ss.4(t)(xvii)(F) above.

                           (xxiii)  No power under the Pension Schemes has been
         exercised in relation to any employee of TARGET and its Subsidiaries or
         in respect of any person:

                                    (A)      to provide terms of membership of
                  the Pension Schemes (whether as to benefits or contributions)
                  which are different from those generally applicable to the
                  members of the Pension Schemes; or

                                    (B)      to provide any benefits which would
                  not but for the exercise of that power have been payable under
                  the Pension Schemes; or

                                    (C)      to augment any benefits under the
                  Pension Schemes.

                           (xxiv)   TARGET and its Subsidiaries:

                                    (A)      have observed and performed those
                  provisions of the Pension Schemes which apply to it; and

                                    (B)      may (without the consent of any
                  person or further payment) terminate its liability to subject
                  to the terms of employment of the active members of the
                  Pension Schemes but otherwise contribute to the Pension
                  Schemes or any other arrangement to which it contributes that
                  provides relevant benefits (as defined in section 612 of the
                  Taxes Act 1988) at any time subject only to giving such notice
                  (if any) as is expressly provided for in the documentation
                  containing the current provisions governing the Pension
                  Schemes.

                           (xxv)    TARGET and its Subsidiaries are the only
         employers for the time being participating in the Pension Schemes. No
         employer other than TARGET and its Subsidiaries has previously
         participated in the Pension Schemes.




<PAGE>   46
                                      -42-


                           (xxvi)   To the Knowledge of the Sellers all
         documentation and records in respect of the Pension Schemes are up to
         date and complete and accurate in all material respects.

                           (xxvii)  To the Knowledge of the Sellers the Save &
         Prosper Scheme:

                                    (A)      is an exempt approved scheme
                  (within the meaning of Section 592(1) Income and Corporation
                  Taxes Act 1988);

                                    (B)      has properly and punctually
                  accounted to the Board of Inland Revenue for all and any tax
                  for which the Pension Schemes is liable or accountable; and

                                    (C)      has at all times complied with and
                  been administered in accordance with all applicable laws,
                  regulations and requirements (including those of the Board of
                  Inland Revenue and of trust law).

                           (xxviii) To the Knowledge of the Sellers none of the
         Pension Schemes, TARGET or any of its Subsidiaries is engaged or
         involved in any litigation or arbitration, investigation or
         determination by the Pensions Ombudsman and/or the Occupational
         Pensions Advisory Service or any complaint under the internal dispute
         resolution procedure established in connection with the Pension Schemes
         which relate to or are in connection with the Pension Schemes or the
         benefits thereunder and no such proceedings are pending or threatened
         and to the Knowledge of the Sellers there are no facts likely to give
         rise to any such proceedings.

                           (xxix)   In relation to the Pension Schemes or funds
         which are or have been held for the purposes thereof, neither TARGET
         and its Subsidiaries has given an indemnity or guarantee to any person
         (other than in the case of TARGET and its Subsidiaries any general
         indemnity in favour of the trustees or administrator under the
         documentation governing the Pension Schemes).

                  (u)      GUARANTEES. Neither TARGET nor any of its
Subsidiaries is a guarantor or otherwise is liable for any Liability or
obligation (including indebtedness) of any other Person.

                  (v)      ENVIRONMENTAL, HEALTH, AND SAFETY MATTERS. Except as
disclosed in ss.4(v) of the Disclosure Schedule:

                           (i)      Hazardous Materials have not at any time
         been generated, used, treated or stored by TARGET and its Subsidiaries
         in violation in any material respect of any applicable Environmental
         Law, or in any way which will hereafter require material 



<PAGE>   47
                                      -43-


         remedial action under any applicable Environmental law, and TARGET and
         its Subsidiaries have not received any notice of any such violation
         with respect to Hazardous Materials;

                           (ii)     to the Knowledge of the Sellers, there has
         been no spill, discharge, leak, emission, injection, escape, dumping or
         release of any kind onto any property owned or leased by TARGET and its
         Subsidiaries, or into the environment surrounding any such property, of
         Hazardous materials, other than releases permissible under applicable
         Law or allowable under applicable permits;

                           (iii)    TARGET and its Subsidiaries, their
         operations and any property owned, leased or operated by them are in
         compliance in all material respects with (i) all applicable
         Environmental Laws, and (ii) the requirements of any permits issued
         under such laws; and

                           (iv)     there are no pending or threatened claims
         against TARGET and its Subsidiaries or any property owned, leased or
         operated by them relating to Hazardous Materials or environmental
         matters.

None of the circumstances, conditions or occurrences disclosed in ss.4(v) of the
Disclosure Schedule or reflected in the Financial Statements involves or will
result in any material liability on the part of TARGET and its Subsidiaries.

                  (w)      CERTAIN BUSINESS RELATIONSHIPS.

                           (i)      Except as contemplated or permitted by this
         Agreement, disclosed in ss.4(w)(i) of the Disclosure Schedule or
         reflected in the Financial Statements, none of the Sellers is involved
         in any business arrangement or relationship with TARGET and its
         Subsidiaries and none of the Sellers owns any material asset, tangible
         or intangible, which is used in the business of TARGET and its
         Subsidiaries (other than motor vehicles owned and used by Peter
         Nightingale).

                           (ii)     Except as contemplated or permitted by the
         Agreement, disclosed in ss.4(w)(ii) of the Disclosure Schedule or
         reflected in the Financial Statements, neither TARGET nor any of its
         Subsidiaries is involved in any business arrangement or relationship
         with Harrison Clinical Research Limited and Harrison Clinical Research
         Limited does not own any material asset, tangible or intangible, which
         is used in the business of TARGET and its Subsidiaries.

                  (x)      COMPETITION.



<PAGE>   48

                                      -44-


                           (i)      To the Knowledge of the Sellers, TARGET and
         its Subsidiaries are not, and have not been party to, or concerned in
         any agreement, arrangement, understanding or concerted practice, or any
         other conduct or practice (unilateral or otherwise) in relation to the
         Business which constitutes a breach of any relevant undertaking, order,
         assurance or other measure taken under the Fair Trading Act 1973, the
         Restrictive Trade Practices Act 1976 or the Competition Act 1980

                           (ii)     TARGET and its Subsidiaries are not subject
         to any publication, order, condition, undertaking, assurance or similar
         measure or obligation imposed by or under any of the laws referred to
         in ss.4(x)(i).

                           (iii)    TARGET and its Subsidiaries are not, and
         have not been subject to any investigation, request for information,
         notice or other communication (whether formal or informal, and whether
         or not in writing) by any court, governmental or regulatory authority
         pursuant to any of the laws referred to in ss.4(x)(i).

                           (iv)     To the Knowledge of TARGET and its
         Subsidiaries, no such action as is mentioned in ss.4(x)(i) will be
         taken against them in relation to any of their current activities.

                  (y)      DISCLOSURE.

                           (i)      The representations and warranties contained
         in this ss.4 do not contain any untrue statement of a material fact or
         omit to state any material fact necessary in order to make the
         statements and information contained in this ss.4, in light of the
         circumstances under which they were made, not misleading in any
         material respect.

                           (ii)     The contents of the Disclosure Schedule and
         of all documents accompanying it and referred to in it are true and
         accurate in all material respects and fully and clearly disclose every
         matter to which they relate.

         5.       PRE-CLOSING COVENANTS. The Parties agree as follows with
respect to the period between the execution of this Agreement and the Closing.

                  (a)      GENERAL. Each of the Parties will use his, her or its
best efforts to take all action and to do all things necessary, proper, or
advisable in order to consummate and make effective the transactions
contemplated by this Agreement (including satisfaction, but not waiver, of the
closing conditions set forth in ss.7 below).

                  (b)      NOTICES AND CONSENTS. The Sellers will cause each of
TARGET and its Subsidiaries to give any notices to third parties, and will cause
TARGET to use its best efforts to


<PAGE>   49
                                      -45-


obtain any third party consents, that Kendle reasonably may request in
connection with the matters referred to in ss.4(c) above. Each of the Parties
will (and the Sellers will cause TARGET and its Subsidiaries to) give any
notices to, make any filings with, and use its best efforts to obtain any
authorisations, consents, and approvals of governments and governmental agencies
in connection with the matters referred to in ss.3(a)(ii), ss.3(b)(ii), and
ss.4(c) above.

                  (c)      OPERATION OF BUSINESS. The Sellers will not cause or
permit TARGET and its Subsidiaries to engage in any practice, take any action,
or enter into any transaction outside the Ordinary Course of Business without
prior notification to and the consent of Kendle (which consent shall not be
unreasonably withheld or delayed). Without limiting the generality of the
foregoing, the Sellers will not cause or (so far as they are able) permit TARGET
and its Subsidiaries to (i) declare, set aside, or pay any dividend or make any
distribution with respect to its capital stock or redeem, purchase, or otherwise
acquire any of its capital stock, (ii) otherwise engage in any practice, take
any action, or enter into any transaction of the sort described in ss.4(h)
above, or (iii) do any act or omit to do any act, or (so far as they are able)
permit any act or omission to act, which could be reasonably expected to cause
any of the statements contained in ss.4 to not be correct and complete as of the
Closing Date (except as set forth in the Disclosure Schedule). Notwithstanding
anything in this paragraph (c) to the contrary, IRC shall be permitted to take
all reasonable steps necessary to have that certain legal mortgage dated 6
September 1996 in favour of Midland Bank plc fully discharged. The Sellers shall
not be in breach of this paragraph (c) in respect of anything done or omitted or
permitted to be done by TARGET or IRC in the ordinary and proper course of its
trading activities or with the prior written consent or approval of Kendle or in
order to comply with the Sellers' obligations under this Agreement.

                  (d)      PRESERVATION OF BUSINESS. The Sellers shall use their
best efforts to cause TARGET and its Subsidiaries to keep their business and
properties substantially intact, including its present operations, physical
facilities, working conditions and relationships with lessors, licensors,
suppliers, customers and employees.

                  (e)      FULL ACCESS. Each of the Sellers will permit, and the
Sellers will cause TARGET and its Subsidiaries to permit, representatives of
Kendle to have full access at all reasonable times, and in a manner so as not to
interfere with the normal business operations of TARGET and its Subsidiaries, to
all premises, properties, personnel, books, records (including Tax records),
contracts, and documents of or pertaining to TARGET and its Subsidiaries.

                  (f)      NOTICE OF DEVELOPMENTS. The Sellers will give prompt
written notice to Kendle of any material adverse development causing a breach of
any of the representations and warranties in ss.4 above. Each Party will give
prompt written notice to the others of any material adverse development causing
a breach of any of his, her or its own representations and warranties in ss.3
above.


<PAGE>   50
                                      -46-

         6.       POST-CLOSING COVENANTS. The Parties agree as follows with
respect to the period following the Closing.

                  (a)      GENERAL. In case at any time after the Closing any
further action is necessary or desirable to carry out the purposes of this
Agreement, each of the Parties will take such further action (including the
execution and delivery of such further instruments and documents) as any other
Party reasonably may request, all at the sole cost and expense of the requesting
Party (unless the requesting Party is entitled to indemnification therefor under
ss.6 or ss.8 below or under the Tax Deed). The Sellers acknowledge and agree
that, from and after the Closing, Kendle will be entitled to possession of all
documents, books, records (including Tax records), agreements, and financial
data of any sort within the possession of, or under the control of, any Seller
or TARGET and its Subsidiaries, relating to TARGET and its Subsidiaries (other
than such documents, books, records (including Tax records), agreements and
financial data that solely relate to one or more Sellers personally or to their
personal positions).

                  (b)      LITIGATION SUPPORT. In the event and for so long as
any Party actively is contesting or defending against any action, suit,
proceeding, hearing, investigation, charge, complaint, claim, or demand in
connection with (i) any transaction contemplated under this Agreement or (ii)
any fact, situation, circumstance, status, condition, activity, practice, plan,
occurrence, event, incident, action, failure to act, or transaction on or prior
to the Closing Date involving TARGET and its Subsidiaries, each of the other
Parties will co-operate with him, her or it and his, her or its counsel in the
contest or defence, make available their personnel, and provide such testimony
and access to their books and records as shall be reasonably necessary in
connection with the contest or defence, all at the sole cost and expense of the
contesting or defending Party (unless the contesting or defending Party is
entitled to indemnification therefor under ss.8 below).

                  (c)      TRANSITION. None of the Sellers will take any action
that is designed or intended to have the effect of discouraging any lessor,
licensor, customer, supplier, or other business associate of TARGET and its
Subsidiaries from maintaining the same business relationships with TARGET and
its Subsidiaries after the Closing as it maintained with TARGET and its
Subsidiaries prior to the Closing. Each of the Sellers will refer all customer
inquiries relating to the businesses of TARGET and its Subsidiaries to TARGET
and its Subsidiaries from and after the Closing.

                  (d)      CONFIDENTIALITY. Each of the Sellers will treat and
hold as such all of the Confidential Information, refrain from using any of the
Confidential Information (other than Confidential Information that solely
relates to the Seller personally) except in connection with this Agreement or
the business of TARGET and its Subsidiaries and will deliver promptly to Kendle
or destroy, at the request of Kendle, all copies of the Confidential Information
which are 


<PAGE>   51
                                      -47-



in his, her or its possession. In the event that any of the Sellers is requested
or required (by oral question or request for information or documents in any
legal proceeding, interrogatory, subpoena, civil investigative demand, or
similar process) to disclose any Confidential Information, that Seller will
notify Kendle promptly of the request or requirement so that Kendle may seek an
appropriate protective order or waive compliance with the provisions of this
ss.6(d). If, in the absence of a protective order or the receipt of a waiver
hereunder, Seller is compelled to disclose such Confidential Information, Seller
may disclose the Confidential Information to the tribunal; PROVIDED, HOWEVER,
that the disclosing Seller shall use his, her or its reasonable best efforts to
obtain, at the reasonable request of Kendle, an order or other assurance that
confidential treatment will be accorded to such portion of the Confidential
Information required to be disclosed as Kendle shall designate.

                  (e)      TARGET SHARES. Each of the Sellers hereby declares
that for so long as he/she remains the registered holder of any of the TARGET
Shares after Closing he/she will:

                           (i)      hold the TARGET Shares and the dividends and
         other distributions or profits or surplus of other assets declared,
         paid or made in respect of them after Closing and all rights arising
         out of or in connection with them in trust for Kendle and its
         successors in title; and

                           (ii)     deal with and dispose of the TARGET Shares
         and all such dividends, distributions and rights as are described
         in ss.6(e)(i) as Kendle or any such successor may direct.

                  (f)      INDEMNITIES.

                           (i)      The Sellers shall jointly and severally
         indemnify TARGET and its Subsidiaries and any officer of TARGET and its
         Subsidiaries against:

                                    (A)      any Adverse Consequences which
                  TARGET or its Subsidiary are or become liable to pay as a
                  result of any failure to comply with the Pensions Act 1995 by
                  any person in respect of the Save & Prosper Scheme; and

                                    (B)      any Adverse Consequences arising in
                  any way from the lease dated 11 June 1995 by TARGET with
                  respect to office premises at Central Hall, 52-54 Market
                  Street, Ely, Cambridgeshire.

                           (ii)     The liability of the Sellers under this
         ss.6(f) shall be subject to the limitations specified in ss.8(i).

         7.       CONDITIONS TO OBLIGATION TO CLOSE.


<PAGE>   52

                                      -48-


                  (a)      CONDITIONS TO OBLIGATION OF KENDLE. The obligation of
Kendle to consummate the transactions to be performed by it in connection with
the Closing is subject to satisfaction of the following conditions:

                           (i)      the representations and warranties set forth
         in ss.4 above shall have been true and correct in all material respects
         (other than representations and warranties having materiality
         qualifiers, which shall be true and correct in all respects) at and as
         of the date of this Agreement and the representations and warranties
         set forth in ss.3(a) above shall be true and correct in all material
         respects (other than representations having materiality qualifiers,
         which shall be true and correct in all respects) at and as of the
         Closing Date;

                           (ii)     the Sellers shall have performed and
         complied with all of their covenants hereunder in all material respects
         through the Closing;

                           (iii)    no action, suit, or proceeding shall be
         pending or threatened before any court or quasi-judicial or
         administrative agency of any federal, state, local, or foreign
         jurisdiction or before any arbitrator wherein an unfavourable
         injunction, judgment, order, decree, ruling, or charge would (A)
         prevent consummation of any of the transactions contemplated by this
         Agreement, (B) cause any of the transactions contemplated by this
         Agreement to be rescinded following consummation, (C) affect adversely
         the right of Kendle to own TARGET Shares and to control TARGET, or (D)
         affect adversely the right of TARGET to own its assets and to operate
         its businesses (and no such injunction, judgment, order, decree,
         ruling, or charge shall be in effect);

                           (iv)     (A) each Seller shall have delivered to
         Kendle a certificate with respect to the satisfaction of the conditions
         specified above in ss.7(a)(i) and (B) the Sellers shall have delivered
         to Kendle a certificate to the effect that each of the conditions
         specified above in ss.7(a)(ii)-(iii) is satisfied in all respects;

                           (v)      John Glasby and Gillian Gregory shall have
         had full medical examinations and Kendle shall have been satisfied with
         the form and substance of the report on each such medical examination;

                           (vi)     TARGET'S bank creditors shall have given
         their written consent to the transaction contemplated by this Agreement
         (if required) and shall have discharged all Encumbrances given by
         TARGET and its Subsidiaries in their favour;



<PAGE>   53
                                      -49-

                           (vii)    John Glasby, Gillian Gregory and Peter
         Nightingale shall have entered into Employment Agreements in the form
         of Exhibit 7(a)(vii) hereto (the "EMPLOYMENT AGREEMENTS");

                           (viii)   each of the Sellers shall have executed and
         delivered releases in the form of Exhibit 7(a)(viii) hereto (the
         "RELEASES");

                           (ix)     each of the Sellers shall have executed and
         delivered Non-Competition and Non-Disclosure Covenants in the form of
         Exhibit 7(a)(ix) hereto (the "COVENANTS");

                           (x)      no TARGET Material Adverse Change shall have
         occurred; provided, however, if a TARGET Material Adverse Change shall
         have occurred, Kendle and the Sellers shall negotiate in good faith
         with respect to a reasonable adjustment of the Purchase Price. If
         agreement is not reached prior to 22 January 1999 with respect to such
         an adjustment, Kendle may terminate this Agreement for failure of a
         condition precedent;

                           (xi)     (A) TARGET and IRC shall have received all
         authorisations, consents, and approvals of governments and governmental
         agencies referred to in ss.3(a)(ii) and ss.4(c) above, and (B) Kendle
         shall have received all authorisations, consents, and approvals of
         governments and governmental agencies referred to in ss.3(b)(ii);

                           (xii)    Kendle shall have received the resignations,
         effective as of the Closing, of each director, secretary and officer of
         TARGET and its Subsidiaries other than those whom Kendle shall have
         specified in writing at least five Business Days prior to the Closing,
         each delivering to Kendle a deed in form and substance satisfactory to
         Kendle made out in favour of TARGET and/or its Subsidiaries
         acknowledging that he or she has no claim outstanding for compensation
         or otherwise and without any payment under the Employment Rights Act
         1996;

                           (xiii)   each of the Sellers shall have executed and
         delivered to Kendle an affidavit pursuant to ss. 1.1445-2(b)(2) of the
         Treasury Regulations: (A) stating that such Seller is not a
         "non-resident alien" for United States income tax purposes; and (B)
         setting forth that Seller's tax identification number and address;

                           (xiv)    each of the Sellers shall have executed and
         delivered the Escrow Agreement;

                           (xv)     Kendle shall have received (A) all the
         statutory and other books (duly written up to date) of TARGET and each
         of its Subsidiaries and its/their certificate(s) of incorporation, any
         certificates of incorporation on change of name and 


<PAGE>   54
                                      -50-

         common seal(s); (B) transfers of all of the TARGET Shares duly executed
         by the registered holders thereof in favour of Kendle together with the
         relative share certificates; (C) certificates in respect of all issued
         shares in the capital of each of TARGET's Subsidiaries and transfers of
         all shares in any Subsidiary not registered in the name of TARGET or
         another Subsidiary in favour of such Persons as Kendle shall direct;
         and (D) the title deeds to the Premises (other than those title deeds
         properly in the possession of Midland Bank plc);

                           (xvi)    Kendle shall have received an executed Tax
         Deed;

                           (xvii)   the Sellers shall have caused a board
         meeting of TARGET and of each of its Subsidiaries to be held at which
         there shall be (A) passed a resolution to approve, in the case of
         TARGET, the transfers of TARGET Shares and (subject only to due
         stamping) to register, in the register of members, each transferee as
         the holder of the shares concerned; (B) appointed as directors and/or
         secretary such Persons as Kendle may nominate such appointments to take
         effect at the close of the meeting; (C) tendered and accepted the
         resignations and acknowledgements of the directors and secretary
         referred to in ss.7(a)(xii) each such acceptance to take effect at the
         close of the meeting; (D) revoked all existing authorities to banks and
         new authorities shall be given to such banks and on such terms as
         Kendle may direct; (E) changed the situation of the registered office
         and (subject to the Companies Acts) the accounting reference date, each
         as Kendle may direct; and (F) approved and entered into the Employment
         Agreements;

                           (xviii)  Kendle shall have received, certified as
         correct by the secretary of the relevant company, the minutes of each
         board meeting referred to in ss.7(a)(xvii); and

                           (xix)    Kendle shall have received a power of
         attorney from each Seller (if requested by Kendle) in form and
         substance satisfactory to Kendle enabling Kendle to vote the TARGET
         Shares pending Kendle's registration as shareholder.

Kendle may waive any condition specified in this ss.7(a) in writing at or prior
to the Closing.

                  (b)      CONDITIONS TO OBLIGATION OF THE SELLERS. The
obligation of the Sellers to consummate the transactions to be performed by them
in connection with the Closing is subject to satisfaction of the following
conditions:

                           (i)      the representations and warranties set forth
         in ss.3(b) above shall be true and correct in all material respects
         (other than representations and warranties having materiality
         qualifiers, which shall be true and correct in all respects) at and as
         of the Closing Date;



<PAGE>   55
                                      -51-



                           (ii)     Kendle shall have performed and complied
         with all of its covenants hereunder in all material respects through
         the Closing;

                           (iii)    no action, suit, or proceeding shall be
         pending or threatened before any court or quasi-judicial or
         administrative agency of any federal, state, local, or foreign
         jurisdiction or before any arbitrator wherein an unfavourable
         injunction, judgment, order, decree, ruling, or charge would (A)
         prevent consummation of any of the transactions contemplated by this
         Agreement or (B) cause any of the transactions contemplated by this
         Agreement to be rescinded following consummation (and no such
         injunction, judgment, order, decree, ruling, or charge shall be in
         effect);

                           (iv)     Kendle shall have delivered to the Sellers a
         certificate to the effect that each of the conditions specified above
         in ss.7(b)(i)-(iii) is satisfied in all respects;

                           (v)      no material adverse change in the business,
         assets, liabilities, income, financial condition or business prospects
         of the Parent and its subsidiaries taken as a whole ("KENDLE MATERIAL
         ADVERSE CHANGE") shall have occurred since the date of the latest
         Kendle SEC Report; provided, however, that if a Kendle Material Adverse
         Change shall have occurred, the Seller and Kendle shall negotiate in
         good faith with respect to a reasonable adjustment to the Purchase
         Price. If agreement is not reached with respect to such an adjustment
         prior to 22 January 1999, the Sellers may terminate this Agreement for
         failure of a condition precedent; and

                           (vi)     the Parties and TARGET shall have received
         all authorisations, consents, and approvals of governments and
         governmental agencies referred to in ss.3(a)(ii), ss.3(b)(ii), and
         ss.4(c) above.

The Sellers may waive any condition specified in this ss.7(b) if they execute a
writing so stating at or prior to the Closing.

         8.       REMEDIES FOR BREACHES OF THIS AGREEMENT.

                  (a)      SURVIVAL OF REPRESENTATIONS AND WARRANTIES. All of
the representations and warranties of the Sellers contained in ss.4(a)-(j),
ss.4(l)-(u) and ss.4(w)-(x) above shall survive the Closing hereunder and
continue in full force and effect through and until the second anniversary of
the Closing Date. All of the representations and warranties of the Sellers
contained in ss.4(k) and ss.4(v) above shall survive the Closing hereunder and
continue in full force and effect through and until the seventh anniversary of
the Closing Date. All of the other representations and warranties of the Parties
contained in this Agreement (including the representations and warranties of the
Sellers contained in ss.3(a)) shall survive the Closing and continue in full
force and effect forever thereafter (subject to any applicable statutes of
limitations).




<PAGE>   56
                                      -52-


                  (b)      INDEMNIFICATION PROVISIONS FOR BENEFIT OF KENDLE.

                           (i)      In the event any of the Sellers breaches any
         of their representations, warranties, and covenants contained herein
         (other than the covenants in ss.2(a) above and the representations and
         warranties in ss.3(a) above), and, if there is an applicable survival
         period pursuant to ss.8(a) above, provided that Kendle makes a written
         claim for indemnification against any of the Sellers in accordance with
         ss.11(h) below within such survival period, then each of the Sellers
         agrees, on a joint and several basis, to indemnify Kendle, the Parent
         and each of their respective directors, officers and affiliates from
         and against the entirety of any Adverse Consequences any of them may
         suffer through and after the date of the claim for indemnification
         (including any Adverse Consequences any of them may suffer after the
         end of any applicable survival period) resulting from, arising out of,
         or caused by the breach (or the alleged breach).

                           (ii)     In the event any of the Sellers breaches any
         of his or her covenants in ss.2(a) above or any of his or her
         representations and warranties in ss.3(a) above, and, if there is an
         applicable survival period pursuant to ss.8(a) above, provided that
         Kendle makes a written claim for indemnification against the Seller in
         accordance with ss.11(h) below within such survival period, then each
         of the Sellers agrees, on a several basis, to indemnify Kendle, the
         Parent and each of their respective directors, officers and affiliates
         from and against the entirety of any Adverse Consequences any of them
         may suffer through and after the date of the claim for indemnification
         (including any Adverse Consequences any of them may suffer after the
         end of any applicable survival period) resulting from, arising out of,
         or caused by the breach.

                           (iii)    Kendle shall satisfy Sellers'
         indemnification and/or refund obligations under this Agreement by first
         recourse to the monies or assets held in the escrow fund held by The
         Fifth Third Bank, as escrow agent, pursuant to the Escrow Agreement and
         the Sellers shall have no liability to make any payment to Kendle
         hereunder until the escrow fund has been exhausted but recourse to that
         escrow fund shall not constitute Kendle's sole remedy or source for
         satisfaction of indemnification and/or other claims under this
         Agreement.

                  (c)      INDEMNIFICATION PROVISIONS FOR BENEFIT OF THE
SELLERS. In the event Kendle breaches any of its representations, warranties,
and covenants contained herein, and, if there is an applicable survival period
pursuant to ss.8(a) above, provided that any of the Sellers makes a written
claim for indemnification against Kendle in accordance with ss.11(h) below
within such survival period, then Kendle agrees to indemnify each of the Sellers
from and against the entirety of any Adverse Consequences the Seller may suffer
through and after the date of the claim for indemnification (including any
Adverse Consequences the Seller may suffer after the end of any



<PAGE>   57

                                      -53-


applicable survival period) resulting from, arising out of, relating to, in the
nature of, or caused by the breach (or the alleged breach). Kendle shall also
indemnify any Seller from and against the entirety of any Adverse Consequences
such Seller may suffer as a result of any obligations or liability of TARGET or
any TARGET Subsidiary (other than this Agreement) guaranteed by such Seller.

                  (d)      MATTERS INVOLVING THIRD PARTIES.

                           (i)      If any third party shall notify any Party
         (the "INDEMNIFIED PARTY") with respect to any matter (a "THIRD PARTY
         CLAIM") which may give rise to a claim for indemnification against any
         other Party (the "INDEMNIFYING PARTY") under ss.6(f) or this ss.8, then
         the Indemnified Party shall promptly notify each Indemnifying Party
         thereof in writing; PROVIDED, HOWEVER, that no delay on the part of the
         Indemnified Party in notifying any Indemnifying Party shall relieve the
         Indemnifying Party from any obligation hereunder unless (and then
         solely to the extent) the Indemnifying Party thereby is prejudiced.

                           (ii)     Any Indemnifying Party will have the right
         to defend the Indemnified Party against the Third Party Claim with
         legal advisers of its choice reasonably satisfactory to the Indemnified
         Party so long as (A) the Indemnifying Party notifies the Indemnified
         Party in writing within 15 days after the Indemnified Party has given
         notice of the Third Party Claim that the Indemnifying Party will
         indemnify the Indemnified Party from and against the entirety of any
         Adverse Consequences the Indemnified Party may suffer resulting from,
         arising out of, relating to, in the nature of, or caused by the Third
         Party Claim, (B) the Indemnifying Party provides the Indemnified Party
         with evidence reasonably acceptable to the Indemnified Party that the
         Indemnifying Party will have the financial resources to defend against
         the Third Party Claim and fulfil its indemnification obligations
         hereunder, (C) the Third Party Claim involves only money damages and
         does not seek an injunction or other equitable relief, (D) settlement
         of, or an adverse judgment with respect to, the Third Party Claim is
         not, in the good faith judgment of the Indemnified Party, likely to
         establish a precedential custom or practice materially adverse to the
         continuing business interests of the Indemnified Party, and (E) the
         Indemnifying Party conducts the defence of the Third Party Claim
         actively and diligently.

                           (iii)    So long as the Indemnifying Party is
         conducting the defence of the Third Party Claim in accordance with
         ss.8(d)(ii) above, (A) the Indemnified Party may retain separate
         co-counsel at its sole cost and expense and participate in the defence
         of the Third Party Claim, (B) the Indemnified Party will not consent to
         the entry of any judgment or enter into any settlement with respect to
         the Third Party Claim without the prior written consent of the
         Indemnifying Party (not to be withheld unreasonably), and 


<PAGE>   58
                                      -54-

         (C) the Indemnifying Party will not consent to the entry of any
         judgment or enter into any settlement with respect to the Third Party
         Claim without the prior written consent of the Indemnified Party (not
         to be withheld unreasonably).

                           (iv)     In the event any of the conditions in
         ss.8(d)(ii) above is or becomes unsatisfied, however, (A) the
         Indemnified Party may defend against, and consent to the entry of any
         judgment or enter into any settlement with respect to, the Third Party
         Claim in any manner it reasonably may deem appropriate (and the
         Indemnified Party need not consult with, or obtain any consent from,
         any Indemnifying Party in connection therewith), (B) the Indemnifying
         Parties will reimburse the Indemnified Party promptly and periodically
         for the costs of defending against the Third Party Claim (including
         reasonable attorneys' fees and expenses), and (C) the Indemnifying
         Parties will remain responsible for any Adverse Consequences the
         Indemnified Party may suffer resulting from, arising out of, relating
         to, in the nature of, or caused by the Third Party Claim to the fullest
         extent provided in this ss.8.

                  (e)      PAYMENT OF AND INTEREST ON INDEMNIFICATION AMOUNTS.
Each amount claimed in respect of Adverse Consequences shall be payable within
ten (10) days after the date of claim by an Indemnified Party, and such amount
shall bear interest if not paid by such date at the annual rate of ten percent
(10%) until paid in full. Any amount paid by the Sellers to Kendle in respect of
any breach of this Agreement or under the Tax Deed shall be treated for tax
purposes as a reduction in the consideration for the TARGET Shares.

                  (f)      OTHER INDEMNIFICATION PROVISIONS. The foregoing
indemnification provisions are in addition to, and not in derogation of, any
statutory, equitable, or common law remedy (including without limitation any
such remedy arising under Environmental, Health, and Safety Requirements) any
Party may have with respect to TARGET and its Subsidiaries or the transactions
contemplated by this Agreement.

                  (g)      RIGHTS CUMULATIVE. The rights and remedies conferred
on Kendle under this Agreement are cumulative and are additional to and not
exclusive of any rights or remedies provided by law or otherwise available at
any time to Kendle in respect of any breach of this Agreement (including but not
limited to the rights to damages for any loss or additional loss suffered by
Kendle).

                  (h)      INFORMATION. Each of the Sellers agrees with Kendle
(for itself and as trustee for TARGET and the Subsidiaries) and the directors,
employees, agents and advisers of TARGET and the Subsidiaries:

                           (i)      that the giving by TARGET or the
         Subsidiaries and/or any of their directors, employees, agents or
         advisers to any of the Sellers or their agents or advisers of


<PAGE>   59
                                      -55-

         any information or opinion in connection with this Agreement or the Tax
         Deed or the Disclosure Schedule or otherwise in relation to the
         business or affairs of TARGET and/or the Subsidiaries or in connection
         with the negotiation in preparation of this Agreement, the Tax Deed or
         the Disclosure Schedule shall not be deemed a representation, warranty
         or guarantee to the Sellers of the accuracy of such information or
         opinion;

                           (ii)     to waive any right or claim which he may
         have against TARGET or the Subsidiaries or any of their directors,
         employees, agents or advisers for any error, omission or
         misrepresentation in any such information or opinion; and

                           (iii)    that any such right or claim shall not
         constitute a defence to any claim by Kendle under or in relation to
         this Agreement or the Tax Deed.

                  (i)      LIMITATIONS ON INDEMNIFICATION.

                           (i)      No liability shall attach to the Sellers
         under this Agreement or the Tax Deed (other than with respect to
         ss.2(h) above) unless the aggregate amount of such liability shall
         exceed (pound)25,000 but in that event the Sellers shall be liable for
         the whole amount of such liability and not merely the excess.

                           (ii)     The total aggregate amount payable by the
         Sellers with respect to any liabilities accrued under this Agreement
         and the Tax Deed shall not exceed(pound)2,775,000.

                           (iii)    The total aggregate amount payable by any
         Seller under this Agreement and the Tax Deed shall not exceed such
         Seller's pro rata portion of the Purchase Price (which for the
         avoidance of doubt is equal at any time to the sum of such Seller's pro
         rata portion (based on the allocation percentages of the Purchase Price
         as set out on Schedule 1 hereto) of (A) the assets and Parent Shares
         held in the escrow fund pursuant to the Escrow Agreement, (B) all
         assets and Parent Shares (valued at Market Value) released from such
         escrow fund to the Sellers since the Closing Date, and (C) the Cash
         Closing Payment).

                           (iv)     Any claim made against the Sellers under
         this Agreement (excluding a claim under ss.4(k) or under the Tax Deed)
         shall (if it has not been previously satisfied, settled or withdrawn)
         be deemed to be withdrawn at the expiration of 12 months from the date
         of giving notice of such claim unless legal proceedings in respect
         thereof have been commenced by the issuing and service of such
         proceedings against the Sellers.





<PAGE>   60

                                      -56-


                           (v)      Payment of any claim under this Agreement or
         the Tax Deed shall pro tanto satisfy and discharge any other claim
         under this Agreement or the Tax Deed which is capable of being made in
         respect of the same loss.

                           (vi)     The liability of the Sellers in respect of
         any claim under the Tax Deed shall be subject to the further
         limitations set out in the Tax Deed.

                           (vii)    No portion of any liability shall attach to
         the Sellers in respect of a claim under this Agreement (excluding the
         Tax Deed) to the extent that with respect to such portion:

                                    (A)      such claim arises only as a
                  consequence of a change in the law or a change of any
                  previously published extra statutory concession or press
                  release from Inland Revenue or HM Customs and Excise after the
                  Closing Date;

                                    (B)      such claim or the events giving
                  rise to such claim or such claim is increased only as a result
                  of a voluntary act or transaction by or at the request of
                  Kendle or Target or IRC (each a "GROUP COMPANY") or any of
                  their respective directors, officers or employees effected
                  after the Closing Date otherwise than as required by law and
                  otherwise than pursuant to a legally binding commitment of a
                  Group Company entered into before the Closing Date and
                  otherwise than in the ordinary course of business (which shall
                  not include communicating any information to any governmental
                  authority);

                                    (C)      provision or reserve in respect of
                  such amount of such claim is made in the Financial Statements;

                                    (D)      the liability giving rise to such
                  claim would have been insured had TARGET and its Subsidiaries
                  arranged insurance cover with effect from the Closing Date
                  which would be equivalent to the policies currently in force
                  in respect of the Group Companies but only to the extent and
                  limit of such policies; and

                                    (E)      such claim results from or is
                  increased or extended by any change in the accounting policies
                  of any Group Company after the Closing Date unless such change
                  was required under UK GAAP.

                           (viii)   In assessing the liability of the Sellers
         under this Agreement there shall be taken into account any proven tax
         benefit accruing to Kendle or any Group Company as a consequence of the
         relevant breach..


<PAGE>   61
                                      -57-

                           (ix)     The effect of the application of Section
         8(i)(vii) and (viii) shall first be taken into account for the purpose
         of determining the amount of liability for the purposes of Section
         8(i)(i).

                           (x)      Kendle shall not be entitled to recover any
         sum in respect of any claim for breach of any of the warranties or
         otherwise obtain reimbursement or restitution more than once in respect
         of the same loss.

                           (xi)     In the event that Kendle or any Group
         Company is entitled to recover from a third party (whether by payment,
         discount, credit, relief or otherwise howsoever) any sum in relation to
         any loss, liability or damage which is the subject of a claim under
         this Agreement, Kendle shall (or shall procure for so long as it
         remains a Subsidiary of the Parent that the relevant Group Company
         shall):

                                    (A)      notify the Sellers as soon as
                  reasonably practicable and provide such information and
                  assistance as the Sellers may reasonably require relating to
                  such entitlement and the action taken or proposed to be taken
                  or proposed to be taken by Kendle or the relevant Group
                  Company in respect of it;

                                    (B)      take (at the expense of the
                  Sellers) such reasonable steps or proceedings as the Sellers
                  may reasonably require (excluding any steps or proceedings
                  that would be to the commercial detriment of any Group
                  Company) and shall act in accordance with any such
                  requirements of the Sellers subject to Kendle being
                  indemnified by the Sellers against all reasonable costs and
                  expenses incurred in connection therewith and shall keep the
                  Sellers promptly informed of the progress of any such steps,
                  proceedings or actions.

                           (xii)    In the event of the Sellers having paid to
         Kendle an amount in respect of a claim under this Agreement and
         subsequent to the date of making such payment Kendle or any Group
         Company recovers from a third party (whether by payment, discount,
         credit, relief or otherwise howsoever) a sum which is directly related
         to that payment then Kendle shall forthwith repay or procure the
         repayment by the relevant Group Company to the Sellers of so much of
         the amount paid by the third party as does not exceed the sum paid by
         the Sellers to Kendle less (a) the reasonable costs of Kendle or the
         relevant Group Company in recovering such sum (including legal fees),
         and (b) any amounts owed by the Sellers in respect of any other claims
         under this Agreement on the Tax Deed.

                           (xiii)   If any claim under this Agreement (excluding
         the Tax Deed) shall arise by reason of some liability of a Group Member
         which, at the time the claim is notified to the Sellers, is contingent
         only, the Sellers shall not be under any obligation to


<PAGE>   62

                                      -58-


         make any payment to Kendle in respect of such claim until such time as
         the contingent liability shall become an actual liability.

                           (xiv)    Nothing in this Section 8 shall be deemed to
         relieve Kendle from any common law or other duty to mitigate any loss
         or damage incurred by it.

                           (xv)     Any amount paid by the Sellers to Kendle in
         respect of any breach of this Agreement or under the Tax Deed shall be
         treated for tax purposes and not for any other purpose under this
         Agreement or the Tax Deed as a reduction in the consideration for the
         TARGET Shares.

                           (xvvi)   The Sellers will be under no liability in
         respect of any claim under ss.6(f) unless written particulars shall
         have been given to the Sellers within a period of seven years from the
         Closing Date.

         9.       [Intentionally Omitted.]

         10.      TERMINATION.

                  (a)      TERMINATION OF AGREEMENT. Certain of the Parties may
terminate this Agreement as provided below:

                           (i)      Kendle and the Sellers may terminate this
         Agreement by mutual written consent at any time prior to the Closing;

                           (ii)     Kendle may terminate this Agreement by
         giving written notice to the Sellers at any time prior to the Closing
         (A) in the event any of the Sellers has breached any material
         representation, warranty, or covenant contained in this Agreement in
         any material respect, Kendle has notified the Sellers of the breach,
         and the breach has continued without cure for a period of 30 days after
         the notice of breach or (B) if the Closing shall not have occurred on
         or before 22 January 1999, by reason of the failure of any condition
         precedent under ss.7(a) hereof (unless the failure results primarily
         from Kendle itself breaching any representation, warranty, or covenant
         contained in this Agreement); and

                           (iii)    the Sellers may terminate this Agreement by
         giving written notice to Kendle at any time prior to the Closing (A) in
         the event Kendle has breached any material representation, warranty, or
         covenant contained in this Agreement in any material respect, any of
         the Sellers has notified Kendle of the breach, and the breach has
         continued without cure for a period of 30 days after the notice of
         breach or (B) if the Closing shall not have occurred on or before 22
         January 1999, by reason of the failure of 


<PAGE>   63
                                      -59-

         any condition precedent under ss.7(b) hereof (unless the failure
         results primarily from any of the Sellers themselves breaching any
         representation, warranty, or covenant contained in this Agreement).

                  (b)      EFFECT OF TERMINATION. Except as set forth in this
ss.10(b), if any Party terminates this Agreement pursuant to ss.10(a) above, all
rights and obligations of the Parties hereunder shall terminate without any
Liability of any Party to any other Party (except for any Liability of any Party
then in breach). Notwithstanding the foregoing, if after this Agreement has been
executed, Kendle is obligated to consummate the transactions contemplated hereby
and Kendle fails to do so, Kendle shall (i) pay Sellers, as liquidated damages,
an amount equal to four percent (4%) of the Purchase Price and (ii) reimburse
Sellers for all out-of-pocket expenses (including attorneys' and accountants'
fees) TARGET incurs in connection with the transaction contemplated hereby;
PROVIDED, HOWEVER, that this aggregate amount shall not exceed One Hundred and
Fifty Thousand Sterling ((pound)150,000). Notwithstanding the foregoing, if
after this Agreement has been executed, the Sellers are obligated to consummate
the transactions contemplated hereby and any Seller fails to do so, the Sellers
shall (i) pay Kendle, as liquidated damages, an amount equal to four percent
(4%) of the Purchase Price and (ii) reimburse Kendle for all out-of-pocket
expenses (including attorneys' and accountants' fees) Kendle incurs in
connection with the transaction contemplated hereby; PROVIDED, HOWEVER, that
this aggregate amount shall not exceed One Hundred and Fifty Thousand Sterling
((pound)150,000).

         11.      MISCELLANEOUS.

                  (a)      NATURE OF CERTAIN OBLIGATIONS.

                           (i)      The covenants of each of the Sellers in
         ss.2(a) above concerning the sale of his, her or its TARGET Shares to
         Kendle and the representations and warranties of each of the Sellers in
         ss.3(a) above concerning the transaction are several obligations. This
         means that the particular Seller making the representation, warranty,
         or covenant will be solely responsible to the extent provided in ss.8
         above for any Adverse Consequences Kendle may suffer as a result of any
         breach thereof.

                           (ii)     The remainder of the representations,
         warranties, and covenants in this Agreement are joint and several
         obligations. This means that each Seller will be responsible to the
         extent provided in ss.8 above for the entirety of any Adverse
         Consequences Kendle may suffer as a result of any breach thereof.

                  (b)      PRESS RELEASES AND PUBLIC ANNOUNCEMENTS. No Party
shall issue any press release or make any public announcement relating to the
subject matter of this Agreement prior to the Closing without the prior written
approval of Kendle and the Sellers (which approval shall not be unreasonably
withheld or delayed); PROVIDED, HOWEVER, that any Party may make any 


<PAGE>   64

                                      60-

public disclosure it believes in good faith is required by applicable law or any
listing or trading agreement concerning its publicly-traded securities (in which
case the disclosing Party will use its best efforts to advise the other Parties
prior to making the disclosure).

                  (c)      NO THIRD-PARTY BENEFICIARIES. This Agreement shall
not confer any rights or remedies upon any Person other than the Parties and
their respective successors and permitted assigns.

                  (d)      ENTIRE AGREEMENT. This Agreement (including the
documents referred to herein) constitutes the entire agreement among the Parties
and supersedes any prior understandings, agreements, or representations by or
among the Parties, written or oral, to the extent they related in any way to the
subject matter hereof. The Sellers hereby confirm that there are no other
agreements between any of them or any of them and TARGET or its Subsidiaries
other than this Agreement and any agreements referred to in this Agreement.

                  (e)      SUCCESSION AND ASSIGNMENT. This Agreement shall be
binding upon and inure to the benefit of the Parties named herein and their
respective successors and permitted assigns. No Party may assign either this
Agreement or any of his, her or its rights, interests, or obligations hereunder
without the prior written approval of Kendle and the Sellers; provided, however,
that Kendle may (i) assign any or all of its rights and interests hereunder to
one or more of its Affiliates (provided that if any such Affiliate shall cease
to be an Affiliate of Kendle it shall forthwith reassign such rights to Kendle
and pending such re-assignment such rights shall not be exercisable) and (ii)
designate one or more of its Affiliates to perform its obligations hereunder (in
any or all of which cases Kendle nonetheless shall remain responsible for the
performance of all of its obligations hereunder).

                  (f)      COUNTERPARTS. This Agreement may be executed in one
or more counterparts, each of which shall be deemed an original but all of which
together will constitute one and the same instrument.

                  (g)      HEADINGS. The section headings contained in this
Agreement are inserted for convenience only and shall not affect in any way the
meaning or interpretation of this Agreement.

                  (h)      NOTICES. All notices, requests, demands, claims, and
other communications hereunder will be in writing. Any notice, request, demand,
claim, or other communication hereunder shall be deemed duly given if (and then
two Business Days after) it is sent (i) from and to the United Kingdom, by first
class pre-paid post, recorded delivery, or (ii) from or to any place outside the
United Kingdom, by pre-paid priority airmail, international recorded delivery
(or the equivalent thereof), in either case addressed to the intended recipient
as set forth below:





<PAGE>   65
                                      -61-



         IF TO THE SELLERS:                 Michael Roy Broomby
                                            Oak Croft
                                            West Heath Lane
                                            Sevenoaks
                                            Kent TN13 1TA

                                            John Glasby
                                            Owlesden
                                            The Green
                                            Fornham All Saints
                                            Bury St Edmunds
                                            Suffolk IPX 6JX

                                            Gillian Gregory
                                            Briarwood
                                            5 Rectory Road
                                            Bluntisham
                                            Cambridgeshire PE17 3LN

                                            Peter Nightingale
                                            13 Priory Close
                                            Royston
                                            Hertfordshire SG8 7DU

                  COPY TO:                  Hewitson Becke + Shaw
                                            Shakespeare House
                                            42 Newmarket Road
                                            Cambridge CB5 8EP
                                            Attention: James Lawrence

         IF TO KENDLE:                      KENDLE INTERNATIONAL INC.
                                            441 Vine Street
                                            700 Carew Tower
                                            Cincinnati, Ohio  45202
                                            Attention: Paul F. Ritter, Esq.
                                                       General Counsel

                  COPY TO:                  BINGHAM DANA LLP
                                            39 Victoria Street
                                            London SW1H 0EE
                                            Attention: Gerald J. Kehoe, Esq.


<PAGE>   66

                                      -62-

Any Party may send any notice, request, demand, claim, or other communication
hereunder to the intended recipient at the address set forth above using any
other means (including personal delivery, expedited courier, messenger service,
facsimile, ordinary mail, or electronic mail), but no such notice, request,
demand, claim, or other communication shall be deemed to have been duly given
unless and until it actually is received by the intended recipient. Any Party
may change the address to which notices, requests, demands, claims, and other
communications hereunder are to be delivered by giving the other Parties notice
in the manner herein set forth.

                  (i)      GOVERNING LAW. This Agreement shall be governed by
and construed in accordance with English law. In relation to any legal action or
proceedings to enforce this Agreement or arising out of or in connection with
this Agreement, each of the Parties irrevocably submits to the jurisdiction of
the English courts but this Agreement may be enforced by the Parties in any
court of competent jurisdiction.

                  (j)      AMENDMENTS AND WAIVERS. No amendment of any provision
of this Agreement shall be valid unless the same shall be in writing and signed
by Kendle and the Sellers. No waiver by any Party of any default,
misrepresentation, or breach of warranty or covenant hereunder, whether
intentional or not, shall be deemed to extend to any prior or subsequent
default, misrepresentation, or breach of warranty or covenant hereunder or
affect in any way any rights arising by virtue of any prior or subsequent such
occurrence.

                  (k)      SEVERABILITY. Any term or provision of this Agreement
that is invalid or unenforceable in any situation in any jurisdiction shall not
affect the validity or enforceability of the remaining terms and provisions
hereof or the validity or enforceability of the offending term or provision in
any other situation or in any other jurisdiction.

                  (l)      EXPENSES. Each of the Parties will bear his, her or
its own costs and expenses (including legal fees and expenses) incurred in
connection with this Agreement and the transactions contemplated hereby.

                  (m)      CONSTRUCTION. The Parties have participated jointly
in the negotiation and drafting of this Agreement. In the event an ambiguity or
question of intent or interpretation arises, this Agreement shall be construed
as if drafted jointly by the Parties and no presumption or burden of proof shall
arise favouring or disfavouring any Party by virtue of the authorship of any of
the provisions of this Agreement. Any reference to any European Union, national,
local, or foreign statute or law shall be deemed also to refer to all rules and
regulations promulgated thereunder, unless the context requires otherwise.
References to, or any provision of, any treaty, statute, directive, regulation,
decision, order, instrument, by-law or any other law of, or having effect in,
any jurisdiction shall be construed also as references to such provisions as
replaced, 



<PAGE>   67
                                      -63-



amended or re-enacted from time to time. Any statute, statutory instrument,
regulation, by-law or other requirement of US federal, state or local law and
any US legal term of any action, remedy, method of judicial proceeding, legal
documents, legal status, procedure, court, official or any legal concept or
doctrine or other expression shall in respect of any non-US jurisdiction be
deemed to include that which most nearly approximates in such non-US
jurisdiction such US statute, statutory instrument, regulation, by-law or other
requirement of law or legal term. The word "including" shall mean including
without limitation. The Parties intend that each representation, warranty and
covenant contained herein shall have independent significance. If any Party has
breached any representation, warranty or covenant contained herein in any
respect, the fact that there exists another representation, warranty or covenant
relating to the same subject matter (regardless of relative levels of
specificity) which the Party has not breached shall not detract from or mitigate
the fact that the Party is in breach of the first representation, warranty or
covenant. Reference to an Event occurring on or before the Closing Date shall be
deemed to include: (i) any combination of two or more Events all of which shall
have occurred on or before the Closing Date; and (ii) any combination of two or
more Events only the first or some of which shall have occurred on or before
Closing Date provided that, there shall be disregarded any Event which shall
have occurred before the Closing Date in the ordinary course of business of
TARGET; and (iii) any Event which is treated or deemed to occur on or before the
Closing Date for the purposes of any Taxes.

                  (n)      INCORPORATION OF EXHIBITS, ANNEXES, AND SCHEDULES.
The Exhibits, Annexes, and Schedules identified in this Agreement are
incorporated herein by reference and made a part hereof.

                  (o)      SPECIFIC PERFORMANCE. Each of the Parties
acknowledges and agrees that the other Parties would be damaged irreparably in
the event any of the provisions of this Agreement are not performed in
accordance with their specific terms or otherwise are breached. Accordingly,
each of the Parties agrees that the other Parties shall be entitled to an
injunction or injunctions to prevent breaches of the provisions of this
Agreement and to enforce specifically this Agreement and the terms and
provisions hereof in any action instituted in any court having jurisdiction over
the Parties and the matter in addition to any other remedy to which they may be
entitled, at law or in equity.

                  (p)      ADDRESS FOR SERVICE.

                           (i)      Each Seller hereby irrevocably authorises
         and appoints the Sellers' Solicitors marked for the attention of James
         Lawrence (or such other person or persons, being a firm of solicitors
         resident in England, as such Seller may hereafter as regards himself by
         notice in writing to all the other parties hereto from time to time
         substitute) to accept on his behalf service of all legal process
         arising out of or connected with this Agreement to be served prior to
         the seventh anniversary of the Closing Date.


<PAGE>   68
                                      -64-

                           (ii)     Service of such process of the person for
         the time being authorised under ss.11(p)(i) to accept it on behalf of
         such Seller shall be deemed to be service of that process on such
         Seller.

                           (iii)    From the date of this Agreement until the
         Closing Date, Kendle hereby irrevocably authorises and appoints Bingham
         Dana LLP of 39 Victoria Street, London SW1H 0EE (or such other person
         or persons Kendle may hereafter as regards himself by notice in writing
         to all the other parties hereto from time to time substitute) to accept
         on his behalf service of all legal process arising out of or connected
         with this Agreement.

                           (iv)     As of the Closing Date and thereafter,
         Kendle hereby irrevocably authorises and appoints TARGET (or such other
         person or persons, being a firm of solicitors resident in England, as
         Kendle may hereafter as regards himself by notice in writing to all the
         other parties hereto from time to time substitute) to accept on his
         behalf service of all legal process arising out of or connected with
         this Agreement to be served prior to the seventh anniversary of the
         Closing Date.

                           (v)      Service of such process of the person for
         the time being authorised under ss.11(p)(iii) or ss.11(p)(iv) (as
         applicable) to accept it on behalf of Kendle shall be deemed to be
         service of that process on Kendle.


AS WITNESS the hands of the duly authorised representatives of the Parties on
the date first before written.



<PAGE>   69
                                      -65-



     SCHEDULE 1 -- SELLERS, SHARE HOLDINGS, PURCHASE PRICE ALLOCATION, ETC.


<TABLE>
<CAPTION>
- ---------------------------------------------------------------------------------------------------
 SELLERS' NAMES                   NUMBER OF TARGET     NUMBER OF PARENT        ALLOCATED PERCENTAGE 
 AND ADDRESSES                       SHARES HELD      SHARES TO RECEIVE          OF PURCHASE PRICE
- ---------------------------------------------------------------------------------------------------
<S>                                      <C>               <C>                        <C>

Michael Roy Broomby                      19                16,636                     19%
Oak Croft
West Heath Lane
Sevenoaks
Kent TN13 1TA
- ---------------------------------------------------------------------------------------------------
John Glasby                              29                25,392                     29%
Owlesden
The Green
Fornham All Saints
Bury St Edmunds
Suffolk IPX 6JX
- ---------------------------------------------------------------------------------------------------
Gillian Gregory                          29                25,392                     29%
Briarwood
5 Rectory Road
Bluntisham
Cambridgeshire PE17 3LN
- ---------------------------------------------------------------------------------------------------
Peter Nightingale                        23                20,138                     23%
13 Priory Close
Royston
Hertfordshire SG8 7DU
- ---------------------------------------------------------------------------------------------------
</TABLE>



<PAGE>   70
                                      -66-


                             SCHEDULE 2 -- PREMISES



1.       The freehold premises known as 22a Station Road, Ely as registered at
         HM Land Registry under title number CB116324.

2.       The freehold premises known as numbers 24, 26 and 30 Station Road, Ely
         as registered at HM Land Registry under title number CB146364.





<PAGE>   71

                            SCHEDULE 3 - SUBSIDIARIES


<TABLE>
<CAPTION>

- --------------------------------------------------------------------------------
NAME                                 REGISTERED          REGISTERED OFFICE
                                       NUMBER
- --------------------------------------------------------------------------------
<S>                                   <C>                 <C>    

Research Consultants 
    (International) Limited           02348938            Angel House
                                                          24 Station Road
                                                          Ely
                                                          Cambridgeshire CB7 4BS

- --------------------------------------------------------------------------------
</TABLE>




<PAGE>   72
                                      -68-



     SCHEDULE 3(B) -- EXCEPTIONS TO KENDLE'S REPRESENTATIONS AND WARRANTIES



None.



<PAGE>   73
                                      -69-

         SIGNED by                      ) /s/ John Glasby
         JOHN GLASBY                    )
         in the presence of:            )

         Witness: /s/ Brenda Glasby

         Name: Brenda Glasby

         Address: Owlesden
                  The Green 
                  Furnham All Saints
                  Bury St. Edmonds
                  Suffolk IPX 6JX

         Occupation:


         SIGNED by                      ) /s/ Gillian Gregory
         GILLIAN GREGORY
         in the presence of:            )

         Witness: /s/ P.K. Gregory

         Name: P.K. Gregory

         Address: Briarwood
                  5 Rectory Road
                  Bluntisham
                  Cambridgeshire PE17
                  3LN

         Occupation:


         SIGNED by                      ) /s/ Michael Roy Broomby
         MICHAEL ROY BROOMBY            )
         in the presence of:            )

         Witness: /s/ Dr. D. Palmer
 
         Name: Dr. D. Palmer

         Address: Oak Croft
                  West Heath Lane
                  Sevenoaks
                  Kent TN13 1TA
<PAGE>   74
                                      -70-

         Occupation:


         SIGNED by                         ) /s/ Peter Nightingale
         PETER NIGHTINGALE                 )
         in the presence of:               )

         Witness: /s/ Jean Audrey Nightingale

         Name: Jean Audrey Nightingale

         Address: 13 Priory Close
                  Royston
                  Hertfordshire SG8 7DU

         Occupation:


         SIGNED by Timothy M. Mooney       ) /s/ Timothy M. Mooney
         duly authorised for and on        )
         behalf of KENDLE                  )
         U.K. INC.                         )

         Witness: /s/ Paul F. Ritter

         Name: Paul F. Ritter

         Address: Kendle International Inc.
                  441 Vine St.
                  700 Carew Tower
                  Cincinnati, OH 45202       

         Occupation:


















<PAGE>   1

                                                                     EXHIBIT 2.8


                                ESCROW AGREEMENT


         THIS ESCROW AGREEMENT ("Escrow Agreement") is dated as of the 5th day
of January 1999 among KENDLE U.K. INC., an Ohio corporation with a mailing
address of 700 Carew Tower, 441 Vine Street, Cincinnati, Ohio 45202, USA
Attention: Paul F. Ritter, Esq., General Counsel ("Kendle"), and John Glasby
with a notice address of Owlesden, The Green, Fornham All Saints, Bury St.
Edmunds, Suffolk IPX 6JX ("Glasby"), Gillian Gregory with a notice address of
Briarwood, 5 Rectory Road, Bluntisham, Cambridgeshire PE17 3LN ("Gregory"),
Michael Roy Broomby with a notice address of Oak Croft, West Heath Lane,
Sevenoaks, Kent TN13 1TA, ("Broomby") and Peter Nightingale with a notice
address of 13 Priory Close, Royston, Hertfordshire SG8 7DU, ("Nightingale")
(Glasby, Gregory, Broomby and Nightingale collectively, the "Sellers"), and THE
FIFTH THIRD BANK with a mailing address of 38 Fountain Square Plaza, Cincinnati,
Ohio 45263, as the escrow agent hereunder ("Escrow Agent").

                                   BACKGROUND

         A.       Effective as of December 23, 1998 Kendle and the Sellers
entered into a Share Purchase Agreement (the "Purchase Agreement"). Pursuant to
the terms of said Purchase Agreement, Kendle (or its assignee) will purchase
from the Seller all of the issued and outstanding share capital of Research
Consultants (International) Holdings Limited ("Target").

         B.       The parties desire to enter into this Escrow Agreement to
provide for an escrow of Eighty-Seven Thousand Five Hundred Fifty-Eight (87,558)
shares of common stock, no par value per share, of Kendle International Inc.
(the "Parent Shares") to provide financial support for Sellers' obligation to
indemnify Kendle for any breaches of warranty or representation by Sellers under
the Purchase Agreement and Sellers' commitment to retain key employees of the
business of the Target for a period of time after the date hereof.

         C.       The Sellers' respective interests in the Escrow Fund (as
defined hereinafter) are as set forth on Schedule I.

         NOW, THEREFORE, in consideration of the mutual covenants set forth
below and other good and valuable consideration, the parties hereto agree as
follows:

         1.       DESIGNATION AND DELIVERY. Kendle and Sellers hereby designate
The Fifth Third Bank as "Escrow Agent" under this Escrow Agreement. Kendle and
Sellers hereby deliver to the Escrow Agent a copy of the Purchase Agreement,
which agreement is attached hereto as Exhibit "A". Each Seller, in accordance
with the Purchase Agreement, hereby delivers to the Escrow


<PAGE>   2

                                      -2-

Agent, and the Escrow Agent hereby acknowledges receipt of, a certificate or
certificates, each duly endorsed in blank or with stock powers duly endorsed in
blank evidencing the Eighty-Seven Thousand Five Hundred Fifty-Eight (87,558)
Parent Shares (the "Deposit").

         2.       INVESTMENT OF THE DEPOSIT; DIVIDENDS AND DISTRIBUTIONS WITH
RESPECT TO THE DEPOSIT; TRANSFERABILITY.

                  (a)      The Escrow Agent is hereby authorized to invest the
         cash portion (if any) of the Deposit and any other cash in the Escrow
         Fund (as defined hereinafter) in money market funds, including the
         Fifth Third U.S. Treasury Obligations Fund sponsored by the Escrow
         Agent's affiliate, Fifth Third Funds. The Escrow Agent shall cause all
         dividends, distributions (including shares distributed in a stock
         split), proceeds from any sale or liquidation, or other income earned
         on or with respect to the Deposit to be added to the Deposit. Such
         deposited dividends, distributions or other income shall, together with
         the Deposit, constitute the "Escrow Fund" to be distributed as provided
         in Section 5 hereof.

                  (b)      Each Seller shall have the right to direct the Escrow
         Agent as to the exercise of any voting rights pertaining to such
         Seller's pro rata share of the Parent Shares by delivery of written
         instructions to the Escrow Agent and the Escrow Agent shall comply with
         any instructions received from the Seller's Institutional Stockholders.
         In the absence of instructions from such Seller, the Escrow Agent shall
         not vote such Seller's pro rata share of the Parent. Kendle shall
         distribute to the Sellers copies of all notices or correspondence sent
         to shareholders of Kendle International Inc.

                  (c)      The respective interests of the Sellers in the Escrow
         Fund shall not be assignable or transferable, other than by operation
         of law. Written notice of any such assignment or transfer by operation
         of law shall be given to the Escrow Agent and Kendle by such Seller,
         and no such assignment or transfer shall be valid until such notice is
         given. Any assignment or transfer effected by operation of law shall
         continue to be subject to this Escrow Agreement.

         3.       ESCROW AGENT AS CUSTODIAN; EXPENSES. The Escrow Agent shall,
for all purposes of this Escrow Agreement, be treated as and considered legally
a custodian. The Escrow Agent shall be entitled to rely conclusively upon the
written notice provided in Section 5 and may assume the genuineness of all
signatures and documents and the authority of all signatories. The Escrow Agent
shall have no liability except for gross negligence or willful misconduct in the
performance of its duties under this Escrow Agreement. Kendle and the Sellers,
collectively, shall each assume and pay one half (1/2) of all costs and expenses
of the Escrow Agent incurred in its capacity as the Escrow Agent under this
Escrow Agreement. The fees of the Escrow Agent are set forth on Exhibit "B"
attached hereto and incorporated herein.

         4.       RESIGNATION; DISAGREEMENTS.


<PAGE>   3
                                      -3-

                  (a)      The Escrow Agent (and any successor Escrow Agent) may
         at any time resign as such by delivering the Escrow Fund to any
         successor Escrow Agent designated by the other parties hereto in
         writing, or to any court of competent jurisdiction as provided below.
         The resignation of the Escrow Agent will take effect on the earlier of
         (a) the appointment of a successor (including a court of competent
         jurisdiction), or (b) the day which is thirty (30) days after the date
         of delivery of its written notice of resignation to the other parties
         hereto. If at that time Escrow Agent has not received a designation of
         a successor Escrow Agent, Escrow Agent's sole responsibility after that
         time shall be to retain and safeguard the Escrow Fund until receipt of
         a designation of successor Escrow Agent or a joint written disposition
         instruction by the other parties hereto or a final non-appealable order
         of a court of competent jurisdiction.

                  (b)      In the event of any disagreement between the other
         parties hereto resulting in adverse claims or demands being made in
         connection with the Escrow Fund or in the event that Escrow Agent is in
         doubt as to what action it should take hereunder, Escrow Agent shall be
         entitled to retain the Escrow Fund until Escrow Agent shall have
         received (i) a final non-appealable order of a court of competent
         jurisdiction directing delivery of the Escrow Fund, or (ii) a written
         agreement executed by the other parties hereto directing delivery of
         the Escrow Fund, in which event Escrow Agent shall disburse the Escrow
         Fund in accordance with such order or agreement. Any court order shall
         be accompanied by a legal opinion by counsel for the presenting party
         satisfactory to Escrow Agent to the effect that the order is final and
         non-appealable. Escrow Agent shall act on such court order and legal
         opinion without further question. [For this purpose, an order will be
         final and non-appealable if no right of appeal lies in respect of such
         judgment or the time period for giving notice of appeal in respect of
         such judgment has expired with no such notice having been given or the
         parties are otherwise debarred from exercising any right of such
         appeal.]

         5.       TERMINATION AND DISTRIBUTION OF ESCROW.

                  (a)      Except as provided in Section 5(f), this Escrow
         Agreement shall terminate upon the earlier of (i) the date that is the
         second anniversary of the closing of the transactions contemplated by
         the Purchase Agreement (the "Second Anniversary Date") (subject to any
         other outstanding claims to the Escrow Fund), or (ii) the date upon
         which the Escrow Agent shall have distributed the Escrow Fund as
         provided herein;

                  (b)      If, on or prior to the date that is the first
         anniversary of the closing of the transactions contemplated by the
         Purchase Agreement (the "First Anniversary Date"), Kendle shall not
         have delivered to the Escrow Agent and Sellers a notice of claim
         ("Notice of Claim") with respect to the Escrow Fund based on either (i)
         breaches by the Sellers of warranties or representations contained in
         the Purchase Agreement, and/or (ii) a reduction in the Purchase Price
         (as defined in the Purchase Agreement) pursuant to Section 2(h) of the
         Purchase Agreement, one half (1/2) of the Parent Shares, plus all


<PAGE>   4

                                      -4-


         dividends, distributions and other income earned thereupon, shall
         promptly be released to Sellers by the Escrow Agent;

                  (c)      If, on or prior to the First Anniversary Date, Kendle
         shall have delivered a Notice of Claim to the Escrow Agent and none of
         the Sellers shall have disputed the Notice of Claim within fifteen (15)
         business days after their receipt of the Notice of Claim, the Parent
         Shares, plus all dividends, distributions and other income earned
         thereupon, (or such lesser amount as may be specified in Kendle's
         Notice of Claim), shall promptly be released to Kendle by the Escrow
         Agent;

                  (d)      If, on or prior to the Second Anniversary Date,
         Kendle shall not have delivered to the Escrow Agent and Sellers a
         Notice of Claim, the remaining one half (1/2) of the Parent Shares,
         plus all dividends, distributions and other income earned thereupon,
         shall be promptly released to Sellers by the Escrow Agent;

                  (e)      If, on or prior to the Second Anniversary Date,
         Kendle shall have delivered a Notice of Claim to the Escrow Agent and
         none of the Sellers shall have disputed the Notice of Claim within
         fifteen (15) business days after their receipt of the Notice of Claim,
         the remainder of the Parent Shares, plus all dividends, distributions
         and other income earned thereupon, (or such lesser amount as may be
         specified in Kendle's Notice of Claim), shall promptly be released to
         Kendle by the Escrow Agent;

                  (f)      If, on or prior to the Second Anniversary, Kendle
         shall have delivered a Notice of Claim or multiple Notices of Claim to
         the Escrow Agent and Sellers which is or are timely disputed by
         Sellers, the Escrow Agent shall hold the Parent Shares, plus all
         dividends, distributions and other income earned thereupon, until the
         dispute or disputes is or are resolved by a court of competent
         jurisdiction, even if resolution of the disputes occurs after January,
         2001, and shall distribute the Parent Shares, plus all dividends,
         distributions and other income earned thereupon pursuant to ss.4(b);
         and

                  (g)      The value of any Parent Shares released to Kendle
         pursuant to this Section 5 shall be determined by reference to the
         average closing bid price for shares of Kendle common stock on the
         NASDAQ National Market System during the twenty (20) trading days prior
         to either the date that a disputed claim is finally determined or, if a
         claim is not disputed, the date of release.

                  (h)      Any distribution of all or a portion of the Escrow
         Fund to the Sellers shall be made in accordance with the percentages
         set forth opposite the Sellers' respective names on Schedule I.
         Distributions to the Sellers of the Parent Shares shall be made by
         submitting the appropriate Parent Shares to the transfer agent of
         Kendle International Inc., who shall be directed to re-register such
         Parent Shares in the names of the Sellers (as applicable) for transfer
         and/or mailing checks to such Sellers at their respective addresses



<PAGE>   5

                                      -5-


         shown on Schedule I (or such other address as may be provided in
         writing to the Escrow Agent by any Seller).

                  (i)      No fractional Parent Shares shall be distributed from
         the Escrow Fund. Instead, the number of Parent Shares that each Seller
         shall receive shall be rounded up or down to the nearest whole number
         such that the total amount of Parent Shares allocated among the Sellers
         shall not exceed the aggregate number of Parent Shares in the Escrow
         Fund. Any remaining unallocated Parent Shares shall be sold by the
         Escrow Agent for fair market value and the proceeds of such sale shall
         be distributed among the Sellers in accordance with the percentages set
         forth opposite the Sellers' respective names on Schedule I.

         6.       DUTIES OF ESCROW AGENT. The duties of the Escrow Agent under
this Escrow Agreement shall be entirely administrative and the Escrow Agent
shall not be liable to any third party as a result of any action or omission
taken or made by it, if taken in good faith, except for gross negligence or
willful misconduct in performing its duties. In the event of disagreement or
dispute between Kendle and Sellers with respect to disposition of the Escrow
Fund, the Escrow Agent shall promptly initiate an appropriate legal proceeding
to obtain a judicial determination of the respective parties' rights to the
Escrow Fund. No rights are intended to be granted to any third party hereunder.
Kendle and Sellers shall severally (each being responsible for fifty percent
(50%) of the indemnity account) indemnify, defend and hold harmless the Escrow
Agent and reimburse the Escrow Agent from and for any and all liability, costs
and expenses, including reasonable attorneys' fees, the Escrow Agent may suffer
or incur by reason of its execution and performance of this Escrow Agreement.
The Escrow Agent shall have no duties except those which are expressly set forth
herein, and it shall not be bound by any notice of a claim, or demand with
respect thereto, or any waiver, modification, amendment, termination or recision
of this Escrow Agreement, unless in writing received by it and signed by Kendle
and/or Sellers.

                  In the event that the Escrow Agent shall find it necessary to
consult with counsel of its own choosing in connection with this Escrow
Agreement, the Escrow Agent shall not incur any liability for any action taken
in good faith in accordance with such advice. Kendle and Sellers, jointly and
severally, shall indemnify and hold harmless the Escrow Agent for any liability,
loss, claim or damage incurred by the Escrow Agent in connection with this
Escrow except for any such liability, costs, expenses (including reasonable
attorneys' fees), loss, claims or damage which is a result of Escrow Agent's own
gross negligence or willful misconduct. This indemnification shall survive
termination of this Escrow Agreement. Kendle and Sellers agree that Kendle, on
the one hand, and Sellers, collectively, on the other hand, shall each assume
and pay fifty percent (50%) of all amounts due to Escrow Agent as a result of
this indemnification.

                  Escrow Agent is not a party to, and is not bound by, any
agreement, including but not limited to the Purchase Agreement, which may be
evidenced by, or arise out, the foregoing instruction, other than as expressly
set forth herein. In the event that any of the terms and provisions of any other
agreement (excluding any amendment to this Escrow Agreement)


<PAGE>   6
                                      -6-


between any of the parties hereto, conflict or are inconsistent with any of the
provisions of this Escrow Agreement, the terms and provisions of this Escrow
Agreement shall govern and control in all respects.

         7.       NOTICES. All notices, consents or other communications
required or permitted to be given under this Escrow Agreement shall be in
writing and shall be deemed to have been duly given:

                  (a)      when delivered personally,

                  (b)      five (5) business day after being sent by an

         overnight delivery service, postage or delivery charges prepaid, or

                  (c)      on the date on which a facsimile is transmitted to
         the parties at their respective addresses stated above.

Any party may change its address for notice and the address to which copies must
be sent by giving notice of the new addresses to the other parties in accordance
with this Section 7, except that any such change of address notice shall not be
effective unless and until received.

         8.       AMENDMENT. No amendment or modification of this Escrow
Agreement shall be effective unless in writing and signed by the parties.

         9.       PARTIES IN INTEREST. This Escrow Agreement shall bind,
benefit, and be enforceable by and against each party hereto and their
successors, assigns, heirs and personal representatives. No party shall in any
manner assign any of its rights or obligations under this Escrow Agreement
without the express prior written consent of the other parties, which consent
shall not be unreasonably withheld.

         10.      NO WAIVERS. No waiver with respect to this Escrow Agreement
shall be enforceable unless in writing and signed by the party against whom
enforcement is sought. Except as otherwise expressly provided herein, no failure
to exercise, delay in exercising, or single or partial exercise of any right,
power or remedy by any party, and no course of dealing between or among any of
the parties, shall constitute a waiver of, or shall preclude any other or
further exercise of the same or any other right, power or remedy.

         11.      SEVERABILITY. If any provision of this Escrow Agreement is
construed to be invalid, illegal or unenforceable, then the remaining provisions
hereof shall not be affected thereby and shall be enforceable without regard
thereto.

         12.      COUNTERPARTS. This Escrow Agreement may be executed in any
number of counterparts, each of which when so executed and delivered shall
constitute an original hereof, 


<PAGE>   7

                                      -7-



and it shall not be necessary in making proof of this Escrow Agreement to
produce or account for more than one original counterpart hereof.

         13.      CONTROLLING LAW. This Escrow Agreement is made under, and
shall be construed and enforced in accordance with, the laws of the State of
Ohio applicable to agreements made and to be performed solely therein, without
giving effect to principles of conflicts of law.

         14.      DEFINITIONS. To the extent not specifically defined herein,
all terms used herein shall have the meanings ascribed to them in the Purchase
Agreement.


                     (remainder of page intentionally blank)


<PAGE>   8

                                      -8-



IN WITNESS WHEREOF, the parties have executed, or caused their duly authorized
representatives to execute, this Escrow Agreement on the date first written
above.



                                        KENDLE U.K. INC.



                                        By: /s/ Timothy M. Mooney
                                            -----------------------------------
                                            Name: Timothy M. Mooney
                                            Title: Vice President and CFO


                                        JOHN GLASBY

                                            /s/ John Glasby 
                                            ------------------------------------


                                        GILLIAN GREGORY

                                            /s/ Gillian Gregory 
                                            ------------------------------------


                                        MICHAEL ROY BROOMBY

                                            /s/ Michael Roy Broomby 
                                            ------------------------------------

                                        PETER NIGHTINGALE

                                            /s/ Peter Nightingale 
                                            ------------------------------------



Received and accepted:

THE FIFTH THIRD BANK
Escrow Agent

By: /s/ Dana Hushak
    --------------------------
    Name: Dana Hushak
    Title:



<PAGE>   9

                                      -9-





                                   EXHIBIT "A"

                               PURCHASE AGREEMENT



<PAGE>   10

                                   EXHIBIT "B"

                                Escrow Agent Fees



Annual Administrative Fee                                             $2,750.00

Fee based on two years of processing beginning on the agreement date. Services
to include:

     -        Review of Escrow Documentation                            INCLUDED

     -        Set - up of Escrow Account                                INCLUDED

     -        Receipt and custody of Escrow Assets                      INCLUDED

     -        Distribution of Assets                                    INCLUDED



Out of pocket expenses including but not limited to: postage, insurance,
stationary, legal fees, etc. will be passed along as incurred. Services not
specifically contemplated herein may be additional. Quotation is subject to
review and acceptance of all applicable documents.




<PAGE>   11

                                      -11-



                                   SCHEDULE I


<TABLE>
<CAPTION>
Seller                                       Percentage Interest in Escrow Fund
- ------                                       ----------------------------------
<S>                                                          <C>

Michael Roy Broomby                                          19%

John Glasby                                                  29%

Gillian Gregory                                              29%

Peter Nightingale                                            23%

</TABLE>














<PAGE>   1

                                                                     Exhibit 2.9


                                OPTION AGREEMENT
- --------------------------------------------------------------------------------

         This Option Agreement (the "Agreement") is made and entered into as of
September 9, 1998, by and among COMPONENT SOFTWARE INTERNATIONAL, INC., an Ohio
corporation ("CSI"); KENDLE INTERNATIONAL INC., an Ohio corporation ("Kendle"),
and certain shareholders of CSI who have executed this Agreement (the
"Shareholders") only with respect to Section 9 of this Agreement.

                                R E C I T A L S

         A. CSI is in the business of providing a variety of information
technology services including consulting, development, testing, and support
services;

         B. Kendle is in the business of providing integrated clinical research
and drug development services on a contractual basis;

         C. CSI and Kendle have entered into a Software Development and License
Agreement dated July 5, 1998, pursuant to which CSI has agreed to provide
certain limited information technology services for Kendle (the "Software
Development Agreement");

         D. The Shareholders own in excess of Eighty Nine percent (89%) of the
issued and outstanding capital stock of CSI;

         E. CSI desires to grant Kendle an option to purchase 206,944 shares of
the common capital stock of CSI in exchange for a payment by Kendle plus
Kendle's commitment to purchase additional information technology services from
CSI on an on-going basis pursuant to the Multi-Year Strategic Services Agreement
in substantially the same form as attached Exhibit A (the "Multi-Year
Agreement"); and

         F. Kendle desires to receive an option to acquire an equity interest in
CSI and desires to obtain additional information technology services from CSI;

         ACCORDINGLY, for good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the parties hereto hereby agree as
follows:


<PAGE>   2


SECTION 1.  GRANT OF OPTION
- --------------------------------------------------------------------------------

         CSI hereby grants to Kendle the right, option and privilege (the
"Purchase Option") to purchase 206,944 shares of the voting, no par common
capital stock of CSI (the "Stock"), on the terms and conditions set forth
herein, which shares constitute ten percent (10%) of the issued and outstanding
common capital stock of CSI as of the date of this Agreement, calculated on a
fully-diluted basis; provided, however, that such number of shares of Stock
shall be reduced prorata to the extent that the number of common shares subject
to exercise or exercised by the HEP Parties (as defined below) under their
Warrants is reduced on or before the Expiration Date. CSI hereby grants the
Purchase Option in consideration of Kendle's payment to CSI of Two Hundred Fifty
Thousand Dollars ($250,000) (the "Option Consideration"). CSI hereby
acknowledges receipt of the Option Consideration. If prior to the earlier of the
Expiration Date (as defined below) or the date on which Kendle elects to
exercise the Purchase Option the outstanding shares of CSI's voting, no par
common stock are changed into or exchanged for a different number or kind of
shares of stock of CSI or of another corporation or other securities, property,
cash or any combination thereof (whether by reason of merger, consolidation,
recapitalization, reclassification, split-up, combination of shares or
otherwise), or in the event a stock split or stock dividend shall have occurred,
then there shall be substituted for each share of Stock then subject to the
Purchase Option the number and kind of shares of stock, other securities,
property, cash or any combination thereof into which each outstanding share of
CSI voting, no par common stock shall be so changed or exchanged, or the number
of shares of CSI voting, no par common stock as is equitably required in the
event of a stock split or stock dividend. Prior to the earlier of the Expiration
Date or the date on which Kendle elects to exercise the Purchase Option, CSI
also shall not, without giving Kendle at least twenty (20) days prior written
notice, establish a record date for the declaration of any dividend or
distribution (other than a stock dividend) on the shares of CSI's voting, no par
common stock, or declare any such dividend or distribution or establish a record
date for the dissolution, liquidation or winding up of CSI or adopt any
resolution of directors or shareholders with respect to a dissolution,
liquidation or winding up of CSI. Further, if any other event occurs prior to
the earlier of the Expiration Date or the date on which Kendle elects to
exercise the Purchase Option as to which the adjustment provisions of the two
(2) immediately preceding sentences are not strictly applicable or, if strictly
applicable, would not fairly protect Kendle's Purchase Option rights, then CSI
shall make an equitable adjustment to the application of those adjustment
provisions so as fairly and fully to protect Kendle's Purchase Option rights.

SECTION 2.  TIME AND MANNER OF EXERCISE
- --------------------------------------------------------------------------------

         The Option may be exercised, in whole only, at any time after the date
of this Agreement and by no later than December 31, 1998 (the "Expiration
Date"). To exercise the Option, Kendle must provide written notice to CSI of its
exercise of the Purchase Option in the form of the attached Exhibit B, "Notice
of Option Exercise," and also must enter into the Multi-Year Agreement.

         Within fifteen (15) days after Kendle's due exercise of the Purchase
Option, Kendle shall deliver the Purchase Price to CSI as described in Section 3
below. Upon receipt of the Purchase 



                                       2
<PAGE>   3


Price from Kendle, CSI shall deliver to Kendle a duly executed certificate or
certificate(s) representing the Stock being issued pursuant hereto, together
with such additional documents as may be reasonably requested by CSI to
effectuate the transfer and to register the same on the books of CSI. Upon
issuance, the shares of Stock shall be duly authorized, validly issued, fully
paid and non-assessable shares of CSI voting, no par common stock, free and
clear of any and all liens, pledges, claims and encumbrances other than
restrictions on transfer under this Agreement, the Multi-Year Agreement and
under applicable federal and state securities laws and regulations.

         If Kendle does not elect to exercise the Purchase Option, CSI shall
retain the Option Consideration and apply it as a credit against additional
information technology services to be provided by CSI for Kendle after the
Expiration Date pursuant to the terms of the Software Development Agreement.

SECTION 3.  EXERCISE PRICE AND PAYMENT
- --------------------------------------------------------------------------------

         3.1      PRICE. As full payment for the Stock, Kendle shall pay CSI Ten
                  Dollars ($10.00) per share with the total consideration for
                  the Stock equal to $2,069,440. Kendle shall be entitled to
                  credit the full amount of the Option Consideration against the
                  exercise price for the Stock.

         3.2      PAYMENT.

                  3.2.1    Of the total Purchase Price described in Section 3.1
                           above, if the historical average of the NASDAQ NMS
                           closing bid price for shares of Kendle's common
                           stock, no par value per share ("Kendle Shares") for
                           the twenty (20) trading days immediately preceding
                           the date on which Kendle exercises the Purchase
                           Option (the "Kendle Share Valuation") is equal to or
                           greater than Twenty- Three and 29/00 Dollars ($23.29)
                           and not greater than Twenty-Eight and 46/00 Dollars
                           ($28.46), then Seventy-Five percent (75%) of the
                           Purchase Price, or One Million Five Hundred Fifty Two
                           Thousand Eighty Dollars ($1,552,080) (including the
                           Option Consideration), shall be paid in cash, with
                           One Million Three Hundred Two Thousand Eighty Dollars
                           ($1,302,080) to be paid by wire transfer of
                           immediately available funds, with the remaining
                           Twenty-Five percent (25%) of the Purchase Price being
                           paid in 19,995 Kendle Shares.

                  3.2.2    Of the total Purchase Price described in Section 3.1
                           above, if the Kendle Share Valuation for the Kendle
                           Shares is greater than Twenty-Eight and 46/00 Dollars
                           ($28.46), then Seventy-Five percent (75%) of the
                           Purchase Price, or One Million Five Hundred Fifty Two
                           Thousand Eighty Dollars ($1,552,080) (including the
                           Option Consideration), shall be paid in cash, with
                           One Million Three Hundred Two Thousand Eighty Dollars
                           ($1,302,080) to be paid by wire transfer of
                           immediately available funds, with the remaining



                                       3
<PAGE>   4


                           Twenty-Five percent (25%) of the Purchase Price being
                           paid in Kendle Shares valued at the Kendle Share
                           Valuation.

                  3.2.3    Of the total Purchase Price described in Section 3.1
                           above, if the Kendle Share Valuation for the Kendle
                           Shares is less than Twenty-Three and 29/00 Dollars
                           ($23.29) and equal to or greater than Twenty and
                           70/00 Dollars ($20.70), then Seventy-Five percent
                           (75%) of the Purchase Price, or One Million Five
                           Hundred Fifty Two Thousand Eighty Dollars
                           ($1,552,080) (including the Option Consideration),
                           shall be paid in cash, with One Million Three Hundred
                           Two Thousand Eighty Dollars ($1,302,080) to be paid
                           by wire transfer of immediately available funds, with
                           the remaining Twenty-Five percent (25%) of the
                           Purchase Price being paid in Kendle Shares valued at
                           the Kendle Share Valuation.

                  3.2.4    Of the total Purchase Price described in Section 3.1
                           above, if the Kendle Share Valuation for the Kendle
                           Shares is less than Twenty and 70/00 Dollars
                           ($20.70), then, at CSI's option, at least
                           Seventy-Five percent (75%) and no more than Ninety
                           percent (90%) of the Purchase Price, or between One
                           Million Five Hundred Fifty Two Thousand Eighty
                           Dollars ($1,552,080) and One Million Eight Hundred
                           Sixty Two Thousand Four Hundred Ninety Six Dollars
                           ($1,862,496) (including the Option Consideration),
                           shall be paid in cash, with an amount equal to the
                           cash portion of the Purchase Price less the Option
                           Consideration to be paid by wire transfer of
                           immediately available funds, and with the remaining
                           ten percent (10%) to Twenty-Five percent (25%) of the
                           Purchase Price being paid in Kendle Shares valued at
                           the Kendle Share Valuation.

         Upon issuance, the Kendle Shares shall be duly authorized, validly
issued, fully paid and non-assessable shares of Kendle common stock, no par
value, free and clear of any and all liens, pledges, claims and encumbrances
other than restrictions on transfer under this Agreement and under applicable
federal and state securities laws and regulations.

SECTION 4.  RESTRICTIONS ON EXERCISE; RESERVATION OF STOCK
- --------------------------------------------------------------------------------

         4.1      Kendle may exercise the Purchase Option only with respect to
                  all of the Stock and no partial exercises shall be permitted.

         4.2      CSI covenants and agrees that, prior to the Expiration Date:
                  (i) CSI shall at all times have authorized, and reserved for
                  the purpose of issue or transfer upon exercise of the Purchase
                  Option, sufficient shares of voting, no par common stock of
                  CSI to provide for the full exercise of the Purchase Option;
                  and (ii) CSI shall take all actions as may be necessary to
                  ensure that the Stock issuable upon exercise of the Purchase
                  Option 



                                       4
<PAGE>   5


                  may be issued without violations of any applicable law or
                  regulation; provided, however, that nothing contained herein
                  shall impose on CSI any obligation to register the Stock under
                  applicable securities laws except as provided in Exhibit C to
                  this Agreement. In the event that any securities of CSI other
                  than shares of CSI's voting, no par common stock are issuable
                  on the exercise by Kendle of the Purchase Option, CSI will
                  take all actions referred to in clauses (i) and (ii) in the
                  preceding sentence as though such clauses applied, mutatis
                  mutandis, to such other securities then issuable upon the
                  exercise of the Purchase Option.

SECTION 5.  CSI REPRESENTATIONS AND WARRANTIES
- --------------------------------------------------------------------------------

         CSI represents and warrants that the following are true and correct on
the date hereof and on the date on which Kendle acquires the Stock pursuant to
exercise of the Purchase Option:

         5.1      CORPORATE STANDING. CSI is a corporation duly organized,
                  validly existing, and in good standing under the laws of the
                  State of Ohio. CSI has all requisite power and authority to
                  own, lease and operate its properties and to carry on its
                  business as now being conducted and as presently proposed to
                  be conducted and to execute, deliver and perform this
                  Agreement. CSI is duly licensed, authorized and qualified to
                  do business and is in good standing in all jurisdictions
                  (domestic or foreign) in which the conduct of its business or
                  the ownership or leasing of its properties requires it to be
                  so licensed, authorized or qualified, except where its failure
                  to be so licensed, authorized or qualified would not have a
                  material adverse effect, singularly or in the aggregate, on
                  the condition (financial or otherwise) of the properties,
                  business, operations or prospects of CSI.

         5.2      AUTHORIZATION. The execution and delivery of this Agreement
                  and the consummation of the transactions contemplated hereby
                  have been duly authorized by all necessary corporate action on
                  the part of CSI. This Agreement has been duly executed and
                  delivered by CSI, and constitutes the legal, valid and binding
                  obligation of CSI, as applicable, enforceable against it in
                  accordance with its terms, except as (i) the enforceability
                  thereof may be limited by bankruptcy, insolvency or similar
                  laws affecting the enforcement of creditors' rights generally
                  and (ii) the availability of equitable remedies may be limited
                  by equitable principles of general applicability.

         5.3      VALIDLY ISSUED SHARES. The shares of Stock to be issued, sold
                  and delivered in accordance with the terms of this Agreement
                  for the consideration set out herein, will, upon issuance in
                  accordance with the terms hereof, be duly authorized and
                  validly issued, fully paid and non-assessable, free and clear
                  of any and all liens, pledges, claims and encumbrances other
                  than restrictions on transfer under this Agreement the
                  Multi-Year Agreement and under applicable federal and state
                  securities laws and regulations. The issuance of the Stock to
                  Kendle pursuant to this 



                                       5
<PAGE>   6


                  Agreement will comply with all applicable laws, including
                  federal and state securities laws and regulations.

         5.4      SUBSIDIARIES; INVESTMENTS. Except as set forth on Schedule
                  5.4, CSI does not own of record or beneficially any notes,
                  obligations, instruments, stock, securities or ownership
                  interests in or of any other corporation, limited liability
                  company, partnership, trust or other person, firm or entity
                  ("Investment"). Schedule 5.4 correctly sets forth the name of
                  each corporation, association or other business entity of
                  which more than fifty percent (50%) of the voting stock or
                  other equity interests is owned or controlled by CSI
                  ("Subsidiary"), the jurisdiction of its incorporation and the
                  persons owning the outstanding capital stock of such
                  Subsidiary. Each Subsidiary is duly organized, validly
                  existing and in good standing under the laws of the
                  jurisdiction of its incorporation, possesses all requisite
                  corporate power and authority and all material licenses,
                  permits and authorizations necessary to own its properties and
                  to carry on its businesses as now being conducted and as
                  presently proposed to be conducted and is qualified to do
                  business in every jurisdiction in which its ownership of
                  property or the conduct of business requires it to qualify
                  except where the failure to so quality would not have a
                  material adverse effect on CSI. All of the outstanding shares
                  of capital stock of each Subsidiary are validly issued, fully
                  paid and nonassessable and all such shares are owned by CSI or
                  another Subsidiary free and clear of any lien and not subject
                  to any option or right to purchase any such shares. Except as
                  set forth on Schedule 5.4, neither CSI nor any Subsidiary owns
                  or holds the right to acquire any shares of stock or any other
                  security or interest in any other person, firm or entity.

         5.5      CAPITALIZATION. As of the date of this Agreement, CSI's
                  authorized capital stock consists of (a) 3,000,000 Common
                  Shares and (b) 1,000,000 Series A Preferred Shares. There are
                  no declared but unpaid dividends or undeclared dividend
                  arrearages on any shares of capital stock of CSI. After giving
                  effect to the exercise of the Purchase Option by Kendle, the
                  only shares of capital stock of CSI issued and outstanding,
                  reserved for issuance or committed to be issued as of the date
                  of this Agreement are:

                           (a) 706,390 fully paid and non-assessable shares of
                  voting, no par common stock, duly issued and outstanding and
                  owned of record and beneficially by the persons, and issued on
                  the dates and for the consideration listed on Schedule 5.5;

                           (b) 237,658 shares of common stock reserved for
                  issuance to employees, officers or directors pursuant to an
                  option or equity incentive plan as approved by the Board;

                           (c) 179,140 shares of common stock reserved for
                  issuance to Strategic Ventures, L.P. pursuant to the Equity
                  Exchange Option Agreement, as amended;



                                       6
<PAGE>   7


                           (d) 550,000 fully paid and non-assessable Series A
                  Preferred Shares, duly issued and outstanding and owned of
                  record and beneficially by Healthcare Equity Partners, L.P.
                  and Healthcare Equity QP Partners, L.P. (the "HEP Parties");

                           (e) 550,000 shares of common stock reserved for
                  issuance upon conversion of the Series A Preferred Shares; and

                           (f) the Warrants issued to the HEP Parties and up to
                  189,306 shares of common stock issuable upon exercise of the
                  Warrants.

                  There are no outstanding preemptive, conversion or other
                  rights, options, warrants or agreements granted or issued by
                  or binding upon CSI for the purchase or acquisition of any
                  shares of its capital stock, other than those issued,
                  reserved, committed to be issued pursuant to this Agreement or
                  as provided for in the Shareholders Agreement, the Articles or
                  otherwise as referred to in this Agreement. All outstanding
                  securities of CSI were issued in compliance with all federal
                  and state securities laws. CSI has no stock appreciation
                  rights or phantom stock plan.

         5.6      FINANCIAL STATEMENTS. CSI has furnished Kendle with (a) the
                  balance sheets of CSI for years ended December 31, 1995,
                  December 31, 1996 and December 31, 1997 (the "Balance Sheet"),
                  together with the statements of operations and changes in
                  financial position for the fiscal year then ended, with the
                  unqualified opinion thereon of Clark, Schaefer, Hackett & Co.
                  (for 1995) and KPMG Peat Marwick (for 1996 and 1997),
                  independent certified public accounts, and a balance sheet and
                  profit and loss statement of CSI for the six (6) months ended
                  June 30, 1998 (collectively, including the Balance Sheet, the
                  "Financial Statements"), and (b) the projected statements of
                  income for CSI for the fiscal years ending December 31, 1998
                  and 1999 (the "Projected Financial Statements"). The Financial
                  Statements have been prepared in accordance with GAAP and
                  fairly and accurately present the financial position of CSI as
                  of December 31, 1995, December 31, 1996, December 31, 1997 and
                  June 30, 1998, respectively, and the results of its operations
                  for the year ended December 31, 1995, the year ended December
                  31, 1996, the year ended December 31, 1997 and the six-month
                  period ended June 30, 1998. The Projected Financial Statements
                  have been prepared by CSI in good faith, based upon
                  information and assumptions reasonably believed by it to be
                  sound and accurate, and its officers and directors do not
                  know, and have no reasonable grounds to know, of any reason
                  such Projected Financial Statements do not represent
                  reasonable forecasts as to CSI's future operations and
                  financial performance. All the books, records and accounts of
                  CSI are in all material respects accurate and complete, are in
                  all material respects in accordance with good business
                  practice and all laws, regulations and rules applicable to CSI
                  and the conduct of its business and accurately present and
                  reflect in all material respects all of the transactions
                  described therein.


                                       7
<PAGE>   8


         5.7      ABSENCE OF UNDISCLOSED LIABILITIES. CSI does not have any
                  material debts, liabilities or obligations of any nature
                  (whether accrued, absolute, contingent, direct, indirect,
                  perfected, inchoate, unliquidated or otherwise and whether due
                  or to become due, including (without limitation) any executive
                  severance compensation arrangements or "golden parachutes")
                  arising out of transactions entered into on or prior to the
                  date hereof, or any transaction, series of transactions,
                  action or inaction occurring on or prior to the date hereof,
                  or any state of facts or condition existing on or prior to the
                  date hereof (regardless of when such liability or obligation
                  is asserted), including, but not limited to, liabilities or
                  obligations on account of taxes or governmental charges or
                  penalties, interest or fines thereon or in respect thereof,
                  except (a) as and to the extent clearly and accurately
                  reflected and accrued for or reserved against in the Balance
                  Sheet (b) for liabilities specifically disclosed on Schedule
                  5.7, and (c) for liabilities and obligations arising after
                  December 31, 1997 in the ordinary course of business
                  consistent with past customs and practice, none of which would
                  exceed $10,000 in the aggregate. CSI and its officers and
                  directors do not know, and have no reasonable grounds to know,
                  of any basis for the assertion against CSI as of the date
                  hereof of any material liabilities not adequately reflected or
                  reserved against on the Balance Sheet.

         5.8      ABSENCE OF CERTAIN CHANGES. Since December 31, 1997, except as
                  set forth on Schedule 5.8, there has not been (a) any change,
                  occurrence, condition or development that has materially and
                  adversely affected, or is likely to materially and adversely
                  affect, CSI's business, affairs, assets, prospects,
                  operations, employee or vendor relations or condition
                  (financial or otherwise), or ability to meet its obligations
                  hereunder, (b) any dividend or other distribution, or any
                  recapitalization, combination or subdivision with respect to,
                  or any purchase or redemption by CSI of, any shares of its
                  capital stock, (c) any indebtedness incurred by CSI, (d) any
                  sale, transfer, lease, mortgage or pledge of, grant of
                  security interest in or other lien against any of CSI's assets
                  or cancellation of any claims of, or indebtedness or
                  obligations owing to CSI except as a result of payments of
                  obligations in the ordinary course of business consistent with
                  past customs and practice (e) any increase or change, (or
                  offer or promise thereof, whether or not legally binding) in
                  salaries or other compensation or employee benefits with
                  respect to any employees of CSI, (f) any purchase of or
                  agreement to purchase any additional assets by CSI at a cost
                  of greater than $5,000 in any one instance, (g) cancellation
                  or compromise by CSI of any debt or claim or waiver or release
                  of any right of material value, (h) any physical damage,
                  destruction or loss (whether or not covered by insurance)
                  adversely affecting the properties, business or prospects of
                  CSI, (i) any changes in the accounting principles, methods or
                  practices followed by CSI or depreciation or amortization
                  policies or rates theretofore adopted, or (j) any action taken
                  by CSI, its directors or officers or its shareholders to
                  authorize any of the actions contemplated by clauses (a) - (i)
                  above.


                                       8
<PAGE>   9


         5.9      TAX LIABILITIES. CSI has filed all federal, state and local
                  tax reports and returns required by any law or regulation to
                  be filed by it, and such returns are true and correct. CSI has
                  paid all taxes, interest and penalties, if any, reflected on
                  such tax returns or otherwise due and payable by it. The
                  reserves for taxes reflected on the balance sheets included in
                  the Financial Statements are adequate in amount for the
                  payment of all liabilities for all taxes (whether or not
                  disputed) of CSI accrued through the dates of such balance
                  sheets. Any deficiencies proposed as a result of any
                  governmental audits of such tax returns have been paid or
                  settled, and there are no present disputes as to taxes payable
                  by CSI.

         5.10     PROPRIETARY RIGHTS. Schedule 5.10 contains a complete and
                  correct list of all Proprietary Rights owned, used by or
                  licensed to or by CSI, all of which are in good standing.
                  Except as set forth on Schedule 5.10, (a) CSI owns and
                  possesses all right, title and interest in and to, or has a
                  valid license to use, all of the Proprietary Rights necessary
                  for the operation of its business as presently conducted and
                  as proposed to be conducted by it and none of such Proprietary
                  Rights have been abandoned by CSI; (b) no claim by any third
                  person contesting the validity, enforceability, use or
                  ownership of any such Proprietary Rights has been made, is
                  currently outstanding or is threatened, and there is no
                  reasonable basis for any such claim; (c) neither CSI nor any
                  registered agent of CSI has received any notices of, nor is
                  CSI aware of any reasonable basis for, an allegation of, any
                  infringement or misappropriation by, or conflict with, any
                  third person with respect to such Proprietary Rights, nor has
                  CSI or any registered agent of CSI received any claims of
                  infringement or misappropriation of or other conflict with any
                  Proprietary Rights of any third person; and (d) CSI has not
                  infringed, misappropriated or otherwise violated any
                  Proprietary Rights of any third person, and CSI is not aware
                  of any infringement, misappropriation or conflict which will
                  occur as a result of the continued operation of its business.
                  Proprietary Rights means (i) patents, patent applications,
                  patent disclosures and inventions (ii) trademarks, service
                  marks, trade dress, trade names and corporate names and
                  registrations and applications for registration thereof; (iii)
                  copyrights and registrations and applications for registration
                  thereof, (iv) mask works and registrations and applications
                  for registration thereof, (v) computer software, data and
                  documentation, (vi) trade secrets and other confidential
                  information (including, but not limited to, ideas, formulas,
                  compositions, inventions (whether patentable or unpatentable
                  and whether or not reduced to practice), know-how,
                  manufacturing and production processes and techniques,
                  research and development information, drawings,
                  specifications, designs, plans, technical data, copyrightable
                  works, financial and marketing plans and customer and supplier
                  lists and information), (vii) other intellectual property
                  rights, and (viii) copies and tangible embodiments thereof (in
                  whatever form or medium).

         5.11     CONSENTS. No consent, approval, qualification, order or
                  authorization of, or registration, declaration or filing with,
                  any court, administrative agency or



                                       9
<PAGE>   10


                  commission or other governmental authority or instrumentality,
                  domestic or foreign, or other third party is required by or
                  with respect to CSI in connection with the execution and
                  delivery of this Agreement, or the consummation by CSI of the
                  transactions contemplated hereby, which has not already been
                  obtained, except for notices of sale required to be filed with
                  the Securities and Exchange Commission under Regulation D of
                  the Securities Act of 1933, as amended ("Securities Act") or
                  such post closing filings as may be required under applicable
                  state securities laws which will be timely filed within the
                  applicable periods therefor.

         5.12     LITIGATION. There is no action, suit, proceeding or
                  investigation pending or to CSI's knowledge currently
                  threatened against CSI, nor does CSI have any actual knowledge
                  that there is any basis for the foregoing. CSI is not a party
                  or subject to the provisions of any order, writ, injunction,
                  judgment or decree of any court or government agency or
                  instrumentality. There is no action, suit, proceeding or
                  investigation by CSI currently pending or that CSI intends to
                  initiate.

         5.13     COMPLIANCE WITH OTHER INSTRUMENTS. CSI is not in violation or
                  default in any material respect of any provision of its
                  Articles of Incorporation or Code of Regulations, or in any
                  material respect of any instrument, judgment, order, writ,
                  decree or contract to which it is a party or by which it is
                  bound, or, to the best of its knowledge, of any provision of
                  any federal or state statute, rule or regulation applicable to
                  CSI. The execution, delivery and performance of this Agreement
                  and the consummation of the transactions contemplated hereby
                  will not result in any such violation or be in conflict with
                  or constitute, with or without the passage of time and giving
                  of notice, either a default under any such provision,
                  instrument, judgment, order, writ, decree or contract or an
                  event that results in the creation of any lien, charge or
                  encumbrance upon any assets of CSI or the suspension,
                  revocation, impairment, forfeiture, or nonrenewal of any
                  material permit, license, authorization, or approval
                  applicable to CSI, its business or operations or any of its
                  assets or properties.

         5.14     MATERIAL FACTS. This Agreement and the documents or written
                  statements furnished by CSI to Kendle in connection with the
                  transactions contemplated hereby do not contain any untrue
                  statement of a material fact or omit to state any material
                  fact necessary to make the statements contained herein or
                  therein, in light of the circumstances in which they are made,
                  not misleading, except, with respect to assumptions,
                  projections and expressions of opinions or predictions
                  contained in the documents or written materials furnished by
                  CSI, CSI makes only those representations set forth in Section
                  5.6 hereof.

         5.15     INVESTMENT. CSI understands that Kendle Shares received
                  hereunder will not be registered under the Securities Act or
                  under any state securities laws, and are being offered and
                  sold in reliance upon federal and state exemptions for
                  transactions not 



                                       10
<PAGE>   11


                  involving any public offering, CSI is acquiring the Kendle
                  Shares solely for its own account for investment purposes, and
                  not with a view to the distribution thereof, is a
                  sophisticated investor with knowledge and experience in
                  business and financial matters, has received certain
                  information concerning Kendle and has had the opportunity to
                  obtain additional information as desired in order to evaluate
                  the merits and the risks inherent in holding Kendle Shares,
                  and is able to bear the economic risk and lack of liquidity
                  inherent in holding Kendle Shares.

SECTION 6.  KENDLE REPRESENTATIONS AND WARRANTIES
- --------------------------------------------------------------------------------

         Kendle hereby represents and warrants to the Company, as of the date
hereof and on the date on which Kendle acquires the Stock pursuant to exercise
of the Purchase Option, as follows:

         6.1      AUTHORIZATION; BINDING AGREEMENT. This Agreement has been duly
                  authorized, executed and delivered by Kendle and it
                  constitutes the legal, valid and binding obligation of Kendle
                  enforceable against it in accordance with its terms; except as
                  (i) the enforceability thereof may be limited by bankruptcy,
                  insolvency or similar laws affecting the enforcement of
                  creditors' rights generally and (ii) the availability of
                  equitable remedies may be limited by equitable principles of
                  general applicability.

         6.2      CONSENTS. No consent, approval, qualification, order or
                  authorization of, or registration, declaration or filing with,
                  any court, administrative agency or commission or other
                  governmental authority or instrumentality, domestic or
                  foreign, or other third party is required by or with respect
                  to Kendle in connection with the execution and delivery of
                  this Agreement, or the consummation by Kendle of the
                  transactions contemplated hereby, which has not already been
                  obtained.

         6.3      COMPLIANCE WITH OTHER INSTRUMENTS. The execution, delivery and
                  performance of this Agreement and the consummation of the
                  transactions contemplated hereby will not result in any such
                  violation or be in conflict with or constitute, with or
                  without the passage of time and giving of notice, either a
                  default under any such provision, instrument, judgment, order,
                  writ, decree or contract or an event that results in the
                  creation of any lien, charge or encumbrance upon any assets of
                  Kendle or the suspension, revocation, impairment, forfeiture,
                  or nonrenewal of any material permit, license, authorization,
                  or approval applicable to Kendle, its business or operations
                  or any of its assets or properties.

         6.4      RECEIPT OF INFORMATION. Kendle acknowledges that the Stock is
                  not being and will not be registered under the Securities Act
                  or the securities laws of any other jurisdiction in reliance
                  on exemptions thereunder. The Stock has not been and will not
                  be approved or disapproved by the Securities and Exchange
                  Commission or any other governmental authority or agency of
                  any jurisdiction. Kendle represents that it has had an
                  opportunity to ask questions and receive answers from CSI
                  regarding 



                                       11
<PAGE>   12


                  the business, properties, prospects, and financial condition
                  of CSI and to obtain additional information (to the extent CSI
                  possessed such information or could acquire it without
                  unreasonable effort or expense) necessary to verify the
                  accuracy of any information furnished to Kendle or to which
                  Kendle had access.

         6.5      CAPITALIZATION. Kendle's authorized equity securities consist
                  of Fifteen Million (15,000,000) shares of common stock, no par
                  value per share, and One Hundred Thousand (100,000) shares of
                  undesignated preferred stock, no par value per share. As of
                  July 31, 1998, Ten Million Nine Hundred Forty One Thousand
                  Eight Hundred Twenty (10,941,820) shares of common stock were
                  issued and outstanding and no shares of undesignated preferred
                  stock were issued and outstanding. The Kendle Shares to be
                  received by CSI in connection with the transactions
                  contemplated hereby will be duly authorized, validly issued,
                  fully paid and non-assessable shares of common stock free and
                  clear of any and all encumbrances other than restrictions on
                  transfer imposed by federal and state securities laws and
                  regulations.

         6.6      SEC REPORTS. Kendle has timely filed with the Securities and
                  Exchange Commission ("SEC") all materials and documents
                  required to be filed by it under the Securities Exchange Act
                  of 1934 (the "Exchange Act"). All the material and documents
                  filed with the SEC by Buyer since July 2, 1997, including its
                  initial Registration Statement on Form S-1, are hereinafter
                  referred to as the "Kendle SEC Reports." The Kendle SEC
                  Reports, copies of which have been delivered to CSI, are true
                  and correct in all material respects, including the financial
                  statements and other financial information contained therein,
                  and do not omit to state any material fact necessary to make
                  the statements in such Kendle SEC Reports, in light of the
                  circumstances in which they were made, not misleading. The
                  financial statements included in the Kendle SEC Reports fairly
                  present in all material respects the financial condition and
                  the results of operations, changes in stockholders' equity and
                  cash flow of Kendle and its subsidiaries as at the respective
                  dates of and for the periods referred to in such financial
                  statements, all in accordance with generally accepted
                  accounting principles.

SECTION 7.  TRANSFERABILITY OF OPTION
- --------------------------------------------------------------------------------

         Neither party may assign this Agreement in whole or in part to any
party without the prior written consent of the other party hereto; provided,
however, that Kendle may assign this Agreement to a wholly-owned subsidiary of
Kendle (directly or indirectly) or a lower tier wholly-owned subsidiary of
Kendle (directly or indirectly) upon at least seven business days' prior written
notice to CSI.


                                       12
<PAGE>   13


SECTION 8.  NO OBLIGATION TO EXERCISE OPTION
- --------------------------------------------------------------------------------

         Nothing in this Agreement imposes any obligation upon Kendle to
exercise the Purchase Option.

SECTION 9.  CLOSE CORPORATION  STOCK TRANSFER RESTRICTIONS
- --------------------------------------------------------------------------------

         All Stock acquired by Kendle upon exercise of the Purchase Option shall
be subject to the Close Corporation Stock Transfer Restriction and Redemption
Provisions provided on the attached Exhibit C. Kendle shall have piggyback
registration rights as set forth in the attached Exhibit C.

SECTION 10.  EXCLUSIVITY
- --------------------------------------------------------------------------------

         Until the earlier of the Expiration Date or the date that Kendle
notifies CSI in writing that it does not elect to exercise the Purchase Option,
CSI agrees that it will not provide customized information technology
development services for the direct competitors of Kendle as listed or described
on the attached Exhibit D. Notwithstanding the foregoing, nothing within this
Agreement shall in any way limit or restrict CSI's right or ability to continue
to provide services and products for any former or current client of CSI listed
on the attached Exhibit E. In addition, in the event that a then current CSI
customer is acquired (whether by sale of stock, assets, merger or otherwise) by
a Kendle direct competitor, CSI shall be permitted to continue to provide
services for such customer under the terms, and for the remaining term, of the
then existing agreement or work statement (but for no longer period) and in such
event CSI hereby expressly agrees not to disclose any Kendle proprietary
information to such customer.

SECTION 11.  MISCELLANEOUS
- --------------------------------------------------------------------------------

         11.1     BINDING EFFECT; NO THIRD PARTY BENEFICIARIES. This Agreement
                  shall be binding upon and shall inure to the successors and
                  permitted assigns of each party. This Agreement is not
                  intended to confer on any person other than the parties hereto
                  or their respective successors and permitted assigns any
                  rights, remedies, obligations or liabilities, expressed or
                  implied, under or by reason of this Agreement.

         11.2     ENTIRE AGREEMENT. This Agreement, together with any Schedules,
                  Exhibits and other documents contemplated hereby, constitutes
                  the final written expression of all of the agreements between
                  the parties, and is a complete and exclusive statement of
                  those terms. It supersedes all prior or contemporaneous
                  understandings and negotiations concerning the matters
                  specified herein. If any representations, promises, warranties
                  or statements made by any party differ in any way from the
                  terms of this written Agreement, any schedules and other
                  documents contemplated hereby, such other representations,
                  promises, warranties or statements shall be given no force or
                  effect. The parties specifically represent, each to the other,
                  that there are no additional or supplemental agreements
                  between them related in any way to the 



                                       13
<PAGE>   14


                  matters herein. No addition to or modification of any
                  provision of this Agreement shall be binding upon any party
                  unless made in writing and signed by all parties.

         11.3     PUBLIC STATEMENTS. Except as required by applicable law or
                  regulations or court order or by the rules of any national
                  securities exchange on which the securities of either Kendle
                  or CSI are quoted or listed, neither CSI nor Kendle shall,
                  without the prior written approval of the other parties
                  hereto, make any press release or other public announcement
                  concerning the transactions contemplated by this Agreement.
                  CSI and Kendle may disclose information with respect to the
                  transaction contemplated hereby to their respective employees,
                  agents, consultants and third parties only to the extent such
                  persons have a need to know such information.

         11.4     GOVERNING LAW AND DISPUTE RESOLUTION. This Agreement shall be
                  governed in all respects by the internal substantive laws of
                  the State of Ohio. Any and all disputes arising out of or in
                  connection with the execution, interpretation, performance, or
                  non-performance of this Agreement or any agreement or other
                  instrument between, involving or affecting the parties
                  (including the validity, scope and enforceability of this
                  arbitration clause), shall be submitted to and resolved by
                  arbitration. The arbitration shall be conducted pursuant to
                  the terms of the Federal Arbitration Act and the Commercial
                  Arbitration Rules of the American Arbitration Association. The
                  arbitration shall be conducted by three arbitrators, who shall
                  be appointed pursuant to the rules of the American Arbitration
                  Association. Either party may notify the other party at any
                  time of the existence of an arbitrable controversy by
                  certified mail and shall attempt in good faith to resolve
                  their differences within fifteen (15) days after the receipt
                  of such notice. If the dispute cannot be resolved within the
                  fifteen-day period, either party may file a written demand for
                  arbitration with the American Arbitration Association. The
                  determination of the arbitrators shall be final and binding on
                  the parties. The place of arbitration shall be Cincinnati,
                  Ohio. Judgment upon the award rendered by the arbitrators may
                  be entered in any court having jurisdiction.

         11.5     WAIVERS. Any party hereto may, by written notice to the other
                  party hereto, to the extent expressly set forth in such
                  written notice: (i) extend the time for the performance of any
                  of the obligations or other actions of the other party under
                  this Agreement; (ii) waive any inaccuracies in the
                  representations or warranties of the other party contained in
                  this Agreement or in any document delivered pursuant to this
                  Agreement; (iii) waive compliance with any of the conditions
                  or covenants of the other party contained in this Agreement;
                  (iv) waive performance of any of the obligations of the other
                  party under this Agreement; or (v) waive an event of default
                  by the other party under this Agreement Except as provided in
                  the preceding sentence, no action taken pursuant to this
                  Agreement, including, without limitation, any investigation by
                  or on behalf of any party, shall be deemed to constitute a
                  waiver by the party taking such action of compliance with any
                  representations, warranties, 



                                       14
<PAGE>   15


                  covenants or agreements contained in this Agreement. No waiver
                  of any provision of this Agreement shall be deemed or shall
                  constitute a waiver of any other provision, whether or not
                  similar, nor shall any waiver constitute a continuing waiver.

         11.6     SEVERABILITY. If for any reason whatsoever, any one or more of
                  the provisions of this Agreement shall be held or deemed to be
                  illegal, inoperative, unenforceable or invalid, such
                  circumstances shall not have the effect of rendering such
                  provision illegal, inoperative, unenforceable or invalid in
                  any other case or of rendering any of the other provisions of
                  this Agreement illegal, inoperative, unenforceable or invalid.
                  In substitution of such illegal, inoperative, unenforceable or
                  invalid provision, there shall be added automatically, as part
                  of this Agreement, a provision as similar in terms of such
                  illegal, invalid, unenforceable or inoperative provision as
                  may be possible and as shall be legal, valid, enforceable and
                  operative.

         11.7     NOTICES. All notices, demands or other communications which
                  may be or are required to be given by any party to any other
                  party pursuant to this Agreement, shall be in writing and
                  shall be mailed by certified mail, return receipt requested,
                  postage prepaid, or transmitted by hand delivery, national or
                  international overnight express, telegram or facsimile
                  transmission, addressed as follows:

                  11.7.1   If to CSI:

                  Component Software International, Inc.
                  8118 Corporate Way
                  Mason, Ohio  45040-9560
                  Attention: Robert P. Beech, CEO

                  with a copy (which shall not constitute notice) to:

                  Graydon, Head & Ritchey
                  1900 Fifth Third Center
                  511 Walnut Street
                  Cincinnati, Ohio 45202
                  Attention: Daniel C. Heyd, Esq.

                  11.7.2   If to Kendle:

                  Kendle International Inc.
                  700 Carew Tower
                  441 Vine Street
                  Cincinnati, Ohio  45202
                  Attention: Timothy M. Mooney, CFO


                                       15
<PAGE>   16


                  with a copy (which shall not constitute notice) to:

                  Kendle International Inc.
                  700 Carew Tower
                  441 Vine Street
                  Cincinnati, Ohio  45202
                  Attention: Paul F. Ritter, Esq.

                  with a copy (which shall not constitute notice) to:

                  Keating, Muething & Klekamp, P.L.L.
                  1800 Provident Tower
                  One East Fourth Street
                  Cincinnati, Ohio 45202
                  Attention: Edward E. Steiner, Esq.

                  until such time as either party notifies the other of a change
                  of address. Each notice or other communication which shall be
                  mailed, delivered or transmitted in the manner described above
                  shall be deemed sufficiently given and received for all
                  purposes at such time as it is delivered to the addressee
                  (with the return receipt, the delivery receipt, or the
                  affidavit of messenger or telefax transmission log being
                  deemed conclusive evidence of such delivery) or at such time
                  as delivery is refused by the addressee upon presentation.

         11.8     COUNTERPARTS; EXECUTION. This Agreement may be executed in as
                  many counterparts as may be required, and each such
                  counterpart hereof shall be deemed to be an original
                  instrument, but all such counterparts together shall
                  constitute but a single agreement. This Agreement shall be
                  deemed to have been executed at the time when and location at
                  which the last signature of any of the parties is affixed
                  hereto or to any counterpart hereof.



                            [signatures on next page]




                                       16
<PAGE>   17


- --------------------------------------------------------------------------------
     IN WITNESS WHEREOF, the parties have executed this Agreement and caused the
same to be duly delivered on their behalf on the day and year hereinabove first
set above.

<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------------------------
CSI:                                                        CSI SHAREHOLDERS
                                                            (FOR PURPOSES OF SECTION 9 AND EXHIBIT C ONLY)
<S>                                                         <C>
COMPONENT SOFTWARE                                          /S/ RICHARD D. EGAN                                   
INTERNATIONAL, INC.                                         ----------------------------------------------       
                                                            RICHARD D. EGAN                                      
                                                                                                                 
                                                                                                                 
BY:                                                         BEECH INVESTORS LIMITED PARTNERSHIP                  
   ----------------------------                                                                                     
TITLE:                                                      BY:/S/ ROBERT P. BEECH                              
      -------------------------                                ----------------------------------------------     
                                                            ROBERT P. BEECH, MANAGING GENERAL PARTNER            

                                                                                                                 
KENDLE:                                                     EGAN INVESTORS LIMITED PARTNERSHIP                   
KENDLE INTERNATIONAL INC.                                                                                        
                                                            BY:/S/ RICHARD D. EGAN                               
BY:                                                            ----------------------------------------------    
   ----------------------------                             RICHARD D. EGAN, MANAGING GENERAL PARTNER            
TITLE:                                                                                                           
      -------------------------                                                                                  
                                                            JOHN A. AND CHRISTINE L. MCCHESNEY FAMILY TRUST      
                                                                                                                 
                                                            BY:                                                  
                                                               ----------------------------------------------    
                                                            JOHN A. MCCHESNEY, TRUSTEE                           
                                                                                                                 
                                                                                                                 
                                                            HEALTHCARE EQUITY PARTNERS L.P.                      
                                                                                                                 
                                                            BY:/S/ KENNETH W. O'KEEFE                            
                                                               ----------------------------------------------    
                                                            TITLE: KENNETH W. O'KEEFE -- MG. DIRECTOR             
                                                                   BEECKEN PATTY & COMPANY, LLC.                  
                                                                   ------------------------------------------
                                                                                                                 
                                                                                                                 
                                                            HEALTHCARE EQUITY QP PARTNERS, L.P.                  
                                                                                                                 
                                                            BY:/S/ KENNETH W. O'KEEFE                            
                                                               ----------------------------------------------    
                                                            TITLE: KENNETH W. O'KEEFE -- MG. DIRECTOR
                                                                   BEECKEN PATTY & COMPANY, LLC.
                                                                   ------------------------------------------
- -----------------------------------------------------------------------------------------------------------------
</TABLE>



<PAGE>   18


- --------------------------------------------------------------------------------
     IN WITNESS WHEREOF, the parties have executed this Agreement and caused the
same to be duly delivered on their behalf on the day and year hereinabove first
set above.

<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------------------------
CSI:                                                        CSI SHAREHOLDERS
                                                            (FOR PURPOSES OF SECTION 9 AND EXHIBIT C ONLY)
<S>                                                         <C>
COMPONENT SOFTWARE                                          /S/ RICHARD D. EGAN                                   
INTERNATIONAL, INC.                                         ----------------------------------------------       
                                                            RICHARD D. EGAN                                      
                                                                                                                 
                                                                                                                 
BY:                                                         BEECH INVESTORS LIMITED PARTNERSHIP                  
   ----------------------------                                                                                  
TITLE:                                                      BY:/S/ ROBERT P. BEECH                              
      -------------------------                                ----------------------------------------------    
                                                            ROBERT P. BEECH, MANAGING GENERAL PARTNER            


KENDLE:                                                     EGAN INVESTORS LIMITED PARTNERSHIP
                                                                                              
KENDLE INTERNATIONAL INC.                                   BY:/S/ RICHARD D. EGAN                               
                                                               ----------------------------------------------    
BY:                                                         RICHARD D. EGAN, MANAGING GENERAL PARTNER            
   ----------------------------                                                                                  
TITLE:                                                                                                           
      -------------------------                             JOHN A. AND CHRISTINE L. MCCHESNEY FAMILY TRUST      
                                                                                                                 
                                                            BY:
                                                               ----------------------------------------------    
                                                            JOHN A. MCCHESNEY, TRUSTEE                           
                                                                                                                 
                                                                                                                 
                                                            HEALTHCARE EQUITY PARTNERS L.P.                      
                                                                                                                 
                                                            BY:
                                                               ----------------------------------------------    
                                                            TITLE:
                                                                  -------------------------------------------
                                                                                                                 
                                                                                                                 
                                                            HEALTHCARE EQUITY QP PARTNERS, L.P.                  
                                                                                                                 
                                                            BY:
                                                               ----------------------------------------------    
                                                            TITLE:
                                                                  -------------------------------------------
- -----------------------------------------------------------------------------------------------------------------
</TABLE>


<PAGE>   19


- --------------------------------------------------------------------------------
     IN WITNESS WHEREOF, the parties have executed this Agreement and caused the
same to be duly delivered on their behalf on the day and year hereinabove first
set above.

<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------------------------
CSI:                                                        CSI SHAREHOLDERS
                                                            (FOR PURPOSES OF SECTION 9 AND EXHIBIT C ONLY)
<S>                                                         <C>
COMPONENT SOFTWARE                                          /S/ RICHARD D. EGAN                                   
INTERNATIONAL, INC.                                         ----------------------------------------------       
                                                            RICHARD D. EGAN                                      
                                                                                                                 
                                                                                                                 
BY:/S/ ROBERT P. BEECH                                      BEECH INVESTORS LIMITED PARTNERSHIP                  
- ----------------------------                                                                                     
TITLE: PRESIDENT AND CEO                                    BY:/S/ ROBERT P. BEECH                              
                                                               ----------------------------------------------    
                                                            ROBERT P. BEECH, MANAGING GENERAL PARTNER            


KENDLE:                                                     EGAN INVESTORS LIMITED PARTNERSHIP
KENDLE INTERNATIONAL INC.                                                                                        
                                                            BY:/S/ RICHARD D. EGAN                               
BY: /S/TIMOTHY M. MOONEY                                       ----------------------------------------------    
- ----------------------------                                RICHARD D. EGAN, MANAGING GENERAL PARTNER            
TITLE: VICE PRESIDENT AND CFO                                                                                     
                                                                                                                 
                                                            JOHN A. AND CHRISTINE L. MCCHESNEY FAMILY TRUST      
                                                                                                                 
                                                            BY:/S/ JOHN A. MCCHESNEY                             
                                                               ----------------------------------------------    
                                                            JOHN A. MCCHESNEY, TRUSTEE                           
                                                                                                                 
                                                                                                                 
                                                            HEALTHCARE EQUITY PARTNERS L.P.                      
                                                                                                                 
                                                            BY:
                                                               ----------------------------------------------    
                                                            TITLE:
                                                                  -------------------------------------------
                                                                                                                 
                                                                                                                 
                                                            HEALTHCARE EQUITY QP PARTNERS, L.P.                  
                                                                                                                 
                                                            BY:                  
                                                               ----------------------------------------------    
                                                            TITLE:
                                                                  -------------------------------------------
- -----------------------------------------------------------------------------------------------------------------
</TABLE>





<PAGE>   1

                                                                    Exhibit 2.10


                            NOTICE OF OPTION EXERCISE


         Kendle International Inc. ("Kendle") hereby provides notice to
Component Software International, Inc. ("CSI), that Kendle is exercising its
rights to acquire 206,944 shares of common stock of CSI, (the "Stock"), pursuant
to Kendle's rights under the Option Agreement dated September 9, 1998 entered
into by CSI and Kendle. In order to induce CSI, to issue the Stock, Kendle
represents and warrants to CSI and Graydon, Head & Ritchey, attorneys for CSI,
as follows:

                  (1) Kendle is aware that the Stock of CSI purchased hereunder
         is speculative and involves a high degree of risk of loss;

                  (2) Kendle has received any and all information relating to
         CSI requested by Kendle, has had an opportunity to ask questions of
         CSI, and is aware of all pertinent information concerning the nature of
         this investment;

                  (3) All documents, records, and books pertaining to this
         investment have been made available to Kendle's attorney, accountant,
         representative, employees and/or officers;

                  (4) Kendle is a sophisticated investor and is sufficiently
         experienced in business or financial affairs or are represented by an
         advisor unaffiliated with CSI who is so skilled and experienced, so
         that Kendle could be reasonably assumed to have the capacity to protect
         Kendle's interests in connection with the transaction;

                  (5) Kendle is an Accredited Investor under applicable federal
         and state securities laws; and all information which Kendle has
         provided to CSI concerning Kendle, Kendle's financial position, and
         Kendle's knowledge of financial information and business matters is
         correct and complete in all material respects as of the date set forth
         at the end hereof, and if there should be any material change in such
         information prior to the acceptance of this subscription Kendle will
         immediately provide CSI with revised information;

                  (6) Kendle is acquiring the Stock solely for Kendle's account,
         as an investment and not with a view to, or for resale in connection
         with, any distribution or public offering, and has no present
         agreement, understanding, or arrangement to subdivide Kendle's Stock or
         to sell, assign, or transfer any portion thereof to any other person;

                  (7) Kendle understands that the Stock may only be disposed of
         pursuant to an effective registration statement filed under the Federal
         Securities Act or pursuant to an exemption from the registration
         requirements of the Securities Act and that Kendle cannot sell such
         Stock without such registration or exemption; that CSI has neither
         filed such a registration statement nor sought such an exemption; that,
         except as set forth in Exhibit C to the Option Agreement, CSI has
         neither agreed to do so nor contemplates doing so in the foreseeable
         future; that in the absence of such a registration statement or such an
         exemption Kendle may have to hold the Stock indefinitely and may be
         unable to liquidate the Stock in case of an emergency;

<PAGE>   2


                  (8) Kendle is aware that this transaction and the Stock to be
         issued upon acceptance of this subscription have not been approved or
         disapproved by the Securities and Exchange Commission or the Division
         of Securities of the State of Ohio or any other State, and that no
         other governmental agency, whether federal, state, or local, has made
         any finding or determination as to the fairness for investment, nor any
         recommendation or endorsement, of the Stock;

                  (9) Kendle understands and acknowledges CSI's obligations
         under, and Kendle agrees not to take any actions which would cause CSI
         to commit a breach under CSI's Amended and Restated Articles of
         Incorporation and a certain Stock Purchase Agreement dated December 31,
         1997 with Healthcare Equity Partners, L.P. and Healthcare Equity QP
         Partners, L.P.

                  (10) Kendle is the sole party in interest as to the Stock and
         is not acquiring any portion of the Stock on behalf of any other person
         or entity who could not make the foregoing representations;

                  (11) Kendle acknowledges that Kendle has either been supplied
         with or have had access to all information to which a reasonable
         investor would attach significance in making investment decisions, and
         Kendle has had the opportunity to ask questions and receive answers
         from knowledgeable individuals concerning CSI and the Stock so that as
         a reasonable investor, Kendle has been able to make a decision to
         purchase the Stock. Kendle has had access during the course of the
         transaction and prior to the sale and delivery of the Stock to the same
         kind of information that is specified in Schedule A of the Securities
         Act of 1933, as amended, relative to the business of CSI, to the extent
         that Kendle has desired to obtain such information from CSI. However,
         nothing in this Notice of Option Exercise shall be deemed to limit or
         expand CSI's warranties and representations under the Option Agreement;
         and

                  (12) Kendle understands and agrees that it will simultaneously
         execute, and be bound by the terms and conditions of the Multi-Year
         Strategic Services Agreement between CSI and Kendle.

                  (13) Kendle represents that it is a corporation organized
         under the laws of Ohio with its principal place of business located in
         the state of Ohio.

                  (14) Kendle represents that it has the full legal power and
         authority to purchase the Stock and that its purchase of the Stock will
         not: (i) violate any provisions of its Articles of Incorporation or
         Regulations; (ii) violate any agreement to which Investor is a party;
         or (iii) violate any law or order of any court or other governmental
         agency applicable to Investor.

<PAGE>   3


                  (15) Kendle understands that each certificate representing the
         Stock shall be imprinted with a legend substantially in the following
         form:

                  The share(s) represented by this Certificate and the other
                  class or classes and series of shares, if any, which the
                  Corporation is authorized to issue are subject to certain
                  express terms contained in the Articles of Incorporation of
                  the Corporation, as amended, a copy of which shall be mailed
                  by the Corporation to any shareholder without charge within
                  five (5) days after receipt of a written request therefor.

                  The securities evidenced by this Certificate have not been
                  registered under the federal Securities Act of 1933, as
                  amended, or any state securities law. Such securities may be
                  transferred only after an effective registration under those
                  Acts or the receipt of an opinion of counsel satisfactory to
                  the Corporation both as to counsel and opinion that the
                  securities may be transferred without registration.

                  The securities represented by this Certificate are subject to
                  restrictions on transfer pursuant to an Option Agreement with
                  the corporation, a copy of which shall be mailed by the
                  Corporation to any shareholder, without charge, within five
                  (5) days after receipt of a written request therefor.

                  The securities represented by this Certificate are subject to
                  certain call rights of the Corporation as set forth in the
                  Multi-Year Strategic Services Agreement, a copy of which shall
                  be mailed by the Corporation to the holder hereof, within five
                  (5) days after receipt of a written request therefor.

         IN WITNESS WHEREOF, the undersigned has executed this instrument of
subscription as of January 11, 1999.




KENDLE INTERNATIONAL INC.

By: /s/ Timothy M. Mooney
   --------------------------

Title: Vice President, CFO
      -----------------------




<PAGE>   4


CSI hereby accepts this subscription.

COMPONENT SOFTWARE INTERNATIONAL, INC.


By:/s/ Robert P. Beech                            Date: January 11, 1999
   --------------------------

Title: President and CEO
      ------------------------


<PAGE>   5



KENDLE
REAL PEOPLE. REAL RESULTS.



A Clinical Development     January 8, 1999
Organization

Corporate Headquarters     Component Software International, Inc. 
700 Carew Tower            8118 Corporate Way 
441 Vine Street            Mason, OH 45040-9560 
Cincinnati, OH 45202       Attn: Richard D. Egan
tel +(001) 513 381 5550
fax +(001) 513 381 5870
[email protected]            Dear Rick:
www.kendle.com
                           As you are aware, Kendle International Inc.
                           ("Kendle") is contemplating the exercise of it's
North America              option as provided in the Option Agreement dated
Chicago, Illinois          September 9, 1998 between Kendle and Component
Cranford, New Jersey       Software International, Inc. ("CSI") (the
Los Angeles, California    "Agreement"). Section 3.2.1 of the Agreement provides
New London, Connecticut    in pertinent part as follows:
Princeton, New Jersey
San Diego, California               "Of the total Purchase Price described in 
                                    Section 3.1 above, if the historical average
                                    of the NASDAQ NMS closing bid price for 
                                                      -----------------  
                                    shares of Kendle's common stock,..." 
                                    (emphasis added).
Europe
London, United Kingdom     For purposes of clarifying and documenting our
Milan, Italy               understanding of Section 3.2.1 of the Agreement, CSI
Munich, Germany            and Kendle agree that the emphasized language should
Utrecht, The Netherlands   refer to the "closing price" of the Kendle shares for
                           the referenced time period as opposed to the "closing
                           bid price".

Asia                       If CSI is in agreement with the foregoing, please
Beijing, China             have a copy of this letter signed and returned to my
Taipei, Taiwan             attention at your earliest convenience. Please call
                           with any questions.

Phase I Unit               Sincerely,
Utrecht, The Netherlands   
                           /s/ Timothy M. Mooney

                           Timothy M. Mooney 
                           VP Finance and Chief Financial Officer


                           AGREED: COMPONENT SOFTWARE INTERNATIONAL, INC.

                           By: /s/ Richard D. Egan                Date: 1-8-99
                              --------------------                     --------
                           Richard D. Egan 
                           Executive VP/Chief Financial Officer


<PAGE>   1
                                                                    Exhibit 2.11

                     MULTI-YEAR STRATEGIC SERVICES AGREEMENT

         THIS MULTI-YEAR STRATEGIC SERVICES AGREEMENT (this "Agreement") is made
and entered into this 20th day of January, 1999, by and between Kendle
International Inc. (hereinafter "Kendle"), an Ohio corporation and Component
Software International, Inc. (hereinafter "CSI"), an Ohio corporation.

                                   WITNESSETH:

         WHEREAS, Kendle desires to engage CSI from time to time pursuant to one
or more Work Statements to develop, create, test, and deliver certain
programming materials and consulting services for use in Kendle's drug
development/contract research business, and CSI is interested in accepting such
engagements, subject to the parties' further agreement on the scope and terms of
each such Work Statement; and

         WHEREAS, Kendle and CSI mutually desire to set forth in this Agreement
certain terms applicable to all such engagements;

         NOW, THEREFORE, Kendle and CSI, intending to be legally bound, hereby
agree as follows:

                                    SECTION 1

                                   DEFINITIONS

         When used in this Agreement and in each Work Statement issued
hereunder, the capitalized terms listed in this Section 1 shall have the
following meanings:

         1.1 CODE -- shall mean computer programming code. If not otherwise
specified, Code shall include both Object Code and Source Code. Code shall
include any Maintenance Modifications or Enhancements thereto created by CSI
from time to time, and shall include Enhancements thereto when added to the Code
in connection with a Work Statement issued hereunder.

                  1.1.1 OBJECT CODE -- shall mean the machine-readable form of
the Code.

                  1.1.2 SOURCE CODE -- shall mean the human-readable form of the
Code and related system documentation including all comments and any procedural
code such as job control language.

         1.2 CONFIDENTIAL INFORMATION -- shall mean: (i) the specifications, the
Product, the CSI-Owned Software, the Kendle-Specific Software and any trade
secrets related to any of the foregoing, including but not limited to any
information relating to either party's product plans, designs, costs, prices and
names, finances, marketing plans, business opportunities, personnel, research,
development or know-how; (ii) any information designated in writing by the
disclosing party as confidential or, if disclosed orally, designated as
confidential at the time of disclosure and reduced 



<PAGE>   2

to writing and designated as confidential in writing within thirty (30) days;
and (iii) the terms, conditions and existence of this Agreement; provided,
however that "Confidential Information" will not include information that: (a)
is or becomes generally known or available by publication, commercial use or
otherwise through no fault of the receiving party; (b) is known and has been
reduced to tangible form by the receiving party at the time of disclosure and is
not subject to restriction; (c) is independently developed by the receiving
party without use of the disclosing party's Confidential Information; (d) is
lawfully obtained from a third party who has the right to make such disclosure;
or (e) is released for publication by the disclosing party in writing.

         1.3 CONTRACT YEAR -- shall mean each 365 day period of January, 20
through January, 19 during the term of this Agreement.

         1.3 CSI -OWNED SOFTWARE -- shall mean all elements or portions of
software included within a Product which are acquired or developed by CSI
outside the scope of this Agreement.

         1.4 DELIVERABLES -- shall mean all Code, Documentation, and other
materials developed for or delivered to Kendle by CSI under this Agreement and
under any Work Statement issued hereunder.

         1.5 DERIVATIVE WORK -- shall mean a work that is based upon one or more
preexisting works, such as a revision, modification, translation, abridgement,
condensation, expansion, or any other form in which such preexisting works may
be recast, transformed, or adapted, and that, if prepared without authorization
of the owner of the copyright in such preexisting work, would constitute a
copyright infringement. For purposes hereof, a Derivative Work shall also
include any compilation that incorporates such a preexisting work.

         1.6 DOCUMENTATION -- shall mean user manuals and other written
materials that relate to particular Code, including materials useful for design
(e.g., logic manuals, flow charts, and principles of operation). Documentation
shall include any Maintenance Modifications or Enhancements thereto created by
CSI from time to time, and shall include Enhancements thereto when added to the
Documentation in connection with a Work Statement issued hereunder.

         1.7 ENHANCEMENTS -- shall mean changes or additions, other than
Maintenance Modifications, to Code and related Documentation, including all new
releases, that improve functions, add new functions, or significantly improve
performance by changes in system design or coding.

         1.8 ERROR -- shall mean any error, problem, or defect resulting from
(1) an incorrect functioning of Code, or (2) an incorrect or incomplete
statement of diagram in Documentation, if such an error, problem, or defect
renders the Code inoperable, causes the Code to fail to meet the specifications
thereof, causes the Documentation to be inaccurate or incomplete in any material
respect, causes incorrect results, or causes incorrect functions to occur when
any such materials are used.





                                       2
<PAGE>   3

         1.9 KENDLE-SPECIFIC SOFTWARE -- shall mean all elements or portions of
software included within a Product which were specifically developed by CSI for
Kendle under this Agreement.

         1.10 MAINTENANCE MODIFICATIONS -- shall mean any modifications or
revisions, other than Enhancements, to Code or Documentation that correct
Errors, support new releases of the operating systems with which the Code is
designed to operate, support new input/output (I/O) devices, or provide other
incidental updates and corrections.

         1.11 PRODUCT -- shall mean the software program(s), including all
Deliverables, Enhancements, Documentation and Code developed by CSI under this
Agreement for Kendle.

         1.12 WORK STATEMENT -- shall mean a written instrument that meets the
following requirements:

              1.     Includes substantially the following statement: "This is a
                     Work Statement under the Multi-Year Strategic Services
                     Agreement dated January 20, 1999."

              2.     Is executed by both parties by their authorized
                     representatives

              3.     Contains the following five mandatory items:

                     a.     Description and/or specifications of the services to
                            be performed and the Deliverables to be delivered to
                            Kendle under the various phases of the work
                            (typically: Needs Analysis, Design and Development);

                     b.     The name and address of a Project Manager for each
                            of Kendle and CSI;

                     c.     The anticipated fees;

                     d.     The time schedule for performance and for delivery
                            of the Deliverables during each phase of work; and

                     e.     Completion and acceptance criteria for the
                            Deliverables under each phase of work.

In addition, when applicable, the Work Statement may include:

              1.     Provisions for written and/or oral progress reports by the
                     CSI;

              2.     Detailed functional and technical specifications and
                     standards for all services and Deliverables, including
                     quality standards;



                                       3
<PAGE>   4



              3.     Documentation standards;

              4.     Lists of any special equipment to be procured by CSI or
                     provided by Kendle for use in performance of the work;

              5.     Test plans and scripts; and

              6.     Such other terms and conditions as may be mutually
                     agreeable between parties.


                                    SECTION 2

                                  CSI SERVICES

         2.1 SERVICES. During the term of this Agreement, CSI agrees to provide
the following services as requested by Kendle: software design and development,
software consulting, information technology industry strategic consulting,
quality assurance planning, management, software testing, and project planning
and management services. These services shall be consistent with CSI's existing
skills and expertise including any new or additional skills and expertise that
CSI elects to provide at CSI's sole discretion.

         2.2 EXCLUSIVITY. During the term of this Agreement and for six months
after the expiration of the four year term of this Agreement, provided that this
Agreement has not been terminated prior to the expiration of the four year term
for any reason other than the uncured breach hereof by CSI, CSI agrees that it
will not provide customized information technology development services for the
direct competitors of Kendle as listed or described on the attached Exhibit A.
Notwithstanding the foregoing, nothing within this Agreement shall in any way
limit or restrict CSI's right or ability to continue to provide services and
products for any former or current client of CSI listed on the attached Exhibit
B. In addition, if a then current CSI customer is acquired (whether by sale of
stock, assets, merger or otherwise) by a Kendle direct competitor, CSI shall be
permitted to continue to provide services for such customer under the terms of,
and for the then remaining term of, the then existing agreement or then existing
work statement with said customer (but for no longer period) and in such event
CSI hereby expressly agrees not to disclose any Kendle proprietary information
to such customer.

                                    SECTION 3

                             CONTRACT ADMINISTRATION

         3.1 PROJECT MANAGER. Upon execution of this Agreement, each party shall
notify the other party of the name, business address, and telephone number of
its Project Manager. The Project Managers of each party shall be responsible for
arranging all meetings, visits, and consultations 


                                       4
<PAGE>   5

between the parties and for technical and performance matters. The Project
Managers shall also be responsible for receiving all notices under this
Agreement and for all administrative matters such as invoices, payments, and
amendments.

         3.2 ISSUANCE OF WORK STATEMENTS. The initial Work Statement(s) agreed
to by the parties are set forth as attachments to this Agreement. Additional
Work Statements, regardless of whether they relate to the same subject matter as
the initial Work Statement(s), shall become effective upon execution by
authorized representatives of both parties. Work Statements may be issued on a
time and materials or a fixed bid basis, as agreed to by the parties on a case
by case basis.

                                    SECTION 4

                                     CHANGES

         Changes in any Work Statement or in any of the Specifications or
Deliverables under any Work Statement shall become effective only when a written
change request is executed by authorized representatives of both parties. All
other change requests with respect to this Agreement, any Work Statement, or any
Specifications or Deliverables must be requested and/or accepted by an
authorized officers of CSI and Kendle.

                                    SECTION 5

                                 NOTICE OF DELAY

         CSI agrees to notify Kendle promptly of any factor, occurrence, or
event coming to its attention that may affect CSI's ability to meet the
requirements of any Work Statement issued under this Agreement, or that is
likely to occasion any material delay in delivery of Deliverables, whether or
not the delay would be excused under the provisions of Section 14.1 hereof. Such
notice shall be given in the event of any loss or reassignment of key employees,
threat of strike, or major equipment failure.

                                    SECTION 6

                                  COMPENSATION

         6.1 TIME AND MATERIALS. Unless otherwise provided within a Work
Statement, Kendle shall pay CSI on the basis of time and materials. Payment
under this method shall be determined according to the hourly rates set for
CSI's employees by skill level and listed in the then current Statement of
Strategic Rates a true, complete, correct and current copy of which has been
delivered separately to Kendle. CSI may change its Statement of Strategic Rates
for each Contract Year with such increases not to exceed: (a) the corresponding
annual percentage increases of the 75th Percentile in the Total Earning category
for Senior Software Developer positions as reported in the 


                                       5
<PAGE>   6

annual Culpepper Software Industry Pay Library (1998 as base year), or (b) the
Strategic Rates charged by CSI to any other customers for similar services at
comparable volume levels.

         6.2      MINIMUM FEES.

                  6.2.1 In light of the commitments made by CSI hereunder
         including CSI's obligation to have resources available to serve
         Kendle's information technology needs, Kendle agrees to incur and pay
         certain minimum fee obligations to CSI during the term of this
         Agreement (the "Annual Minimum"). Specifically, prior to the completion
         of the second Contract Year Kendle shall have requested and incurred
         liability to CSI for services with a minimum aggregate value of
         $3,500,000 (excluding expense reimbursements), with a least $1,000,000
         of such services requested and incurred during the first Contract Year.
         The Annual Minimum amount for the third and fourth Contract Years shall
         each be $1,750,000.

                  6.2.2 Fees incurred by Kendle under the Software License and
         Development Agreement dated July 5, 1998, shall be applied against the
         Annual Minimum amount for the first Contract Year hereunder to cover
         Kendle's Annual Minimum payment obligation for the first Contract Year.
         In addition, if CSI obtains a new client(s) during a Contract Year due
         to the introduction by and the active assistance of Kendle, the fees
         (not expense reimbursements) incurred by such new client(s) ("New
         Client Fees") during the Contract Year shall be applied on a
         dollar-for-dollar basis to cover Kendle's Annual Minimum payment
         obligation for the Contract Year.

                  6.2.3 If the sum of New Client Fees and the fees for which
         Kendle incurs liability in a given Contract Year for CSI services in
         excess of the Annual Minimum for such Contract Year, such excess may be
         divided by the number of Contract Year(s) remaining with such pro-rata
         amount available for use by Kendle to cover Kendle's Annual Minimum
         payment obligation for each of the remaining Contract Year(s).

                  6.2.4 To compensate CSI for the loss (or perceived loss) in
         company value due to Kendle's failure to reach its Annual Minimum
         payment obligation, within thirty (30) days after the completion of a
         Contract Year in which Kendle does not meet its Annual Minimum
         obligation, Kendle shall pay to CSI an amount equal to such deficiency
         as an additional capital contribution for the shares of CSI common
         stock acquired by Kendle pursuant to the Option Agreement dated
         September 9, 1998, without the receipt of any additional CSI common
         shares.




                                       6
<PAGE>   7



                                    SECTION 7

                                    INVOICING

         CSI shall submit invoices to Kendle for payment for work on a monthly
basis. All invoices shall specifically refer to the Work Statement to which they
relate. The invoice shall indicate the names, skill levels, and hours of the
employees performing the work. Each invoice shall separately set forth travel
expenses, if any, authorized by Kendle for reimbursement. Supporting
documentation (e.g., receipts for air travel, hotels, and rental cars) called
for by Kendle's standard reimbursement policies shall accompany any such
invoice. In addition, after the conclusion of each Contract Year CSI shall
submit a statement to Kendle for payment of the additional capital contribution
amount, if any, which shall be equal to the difference between: (x) the Annual
Minimum; and (y) the aggregate amount of fees incurred by Kendle for services
CSI rendered during the prior Contract Year plus all New Client Fees incurred
during the prior Contract Year. All Invoices shall be net 30 days and shall be
addressed to Kendle's Project Manager.

                                    SECTION 8

                                    EXPENSES

         Except as expressly agreed otherwise by Kendle in a Work Statement: (i)
Kendle shall reimburse CSI for any expenses associated with CSI's procurement of
any additional hardware requested by Kendle and approved by Kendle in writing
and reasonable travel related expenses in accordance with CSI's then existing
travel policies; and (ii) CSI shall bear other expenses arising from its
performance of its obligations under this Agreement and each Work Statement
issued hereunder, including (without limitation) expenses for facilities, work
spaces, utilities and management.

                                    SECTION 9

                             DELIVERY AND ACCEPTANCE

         CSI shall deliver all Deliverables, upon completion, to Kendle's
Project Manager for testing and acceptance. CSI shall memorialize such delivery
in a Delivery Confirmation that sets forth the nature and condition of the
Deliverables, the medium of delivery, and the date of their delivery. Kendle's
Project Manager shall countersign such Delivery Confirmation so as to indicate
its receipt of the contents described therein, and the Delivery Confirmation
shall thereupon be transmitted to the parties' Project Managers. Unless a
different procedure for testing and acceptance is set forth in a Work Statement,
Kendle's Project Manager shall commence acceptance testing following its receipt
of the Deliverables to determine whether the Deliverable conforms to the
specification for such Deliverable. Upon completion of such testing, Kendle
shall issue to CSI's Project Manager notice of acceptance or rejection of the
Deliverables. A Deliverable will be deemed accepted by Kendle if CSI does not
receive Kendle's written acceptance or a Statement of Errors within fifteen 


                                       7
<PAGE>   8

(15) business days after the date of delivery of the Deliverable. In the event
of rejection, Kendle shall give its reasons for rejection to CSI's Project
Manager in reasonable detail. CSI shall use all reasonable effort on the same
time and materials payment basis to correct any deficiencies or nonconformities
and resubmit the rejected items as promptly as possible; provided, however, that
CSI's fee for additional time to correct a deficiency or nonconformity shall not
exceed two percent (2%) of the total effort hours expended by CSI to develop and
test the Deliverable at issue.

                                   SECTION 10

                              OWNERSHIP AND RIGHTS

         10.1 CSI-OWNED SOFTWARE. CSI hereby grants to Kendle a perpetual,
royalty-free license to use, modify, reproduce and distribute the CSI-Owned
Software only as a component of the Product or a Derivative Work. However, in no
event shall Kendle be entitled to distribute or otherwise disclose the source
code versions of the CSI-Owned Software. All CSI-Owned Software source code
shall be considered to be Confidential Information and protected as such as
provided under this Agreement.

         10.2 KENDLE-SPECIFIC SOFTWARE. CSI and Kendle agree that upon full
payment of all fees to CSI hereunder, or payment of all fees incurred by Kendle
prior to a breach by CSI of this Agreement, Kendle will own the Kendle-Specific
Software. Subject to such payment obligation by Kendle, CSI hereby grants and
assigns to Kendle, without reservation, all worldwide ownership rights, title
and interest in and to the Kendle-Specific Software including, but not limited
to, patent rights, copy rights, trade secret rights, trademark rights and other
proprietary rights in the Kendle-Specific Software. Kendle and CSI recognize
that the Kendle-Specific Software comprises a number of functional blocks of
code, each of the functional blocks of code performing a function different from
the function of the Kendle-Specific Software. Kendle hereby grants back to CSI a
perpetual, royalty-free-license to use, modify, reproduce and distribute
separate functional blocks of code of the Kendle-Specific Software insofar as
the functional blocks of code used, modified, reproduced or distributed are used
only in connection with products that are not directly competitive with the
Product as reasonably determined by Kendle.

         10.3 CSI'S ASSISTANCE. During and subsequent to the term of this
Agreement, and entirely at Kendle's request and expense and without further
consideration, CSI will document the assignment to Kendle of all rights, title,
and interest in and to the Kendle-Specific Software and any Derivative Works
prepared by CSI and assist Kendle and its nominees in every proper way to
secure, maintain, protect and defend for Kendle's own benefit all copyrights,
patents and other proprietary rights in any and all countries. As part of CSI's
obligation, CSI will execute, at the time of final acceptance of the
Kendle-Specific Software, a document in a form satisfactory to the parties
transferring the copyright rights granted herein to Kendle.






                                       8
<PAGE>   9



                                   SECTION 11

                            CONFIDENTIAL INFORMATION

         Each party will protect the other's Confidential Information from
unauthorized dissemination and use with the same degree of care that each such
party uses to protect its own like information. Neither party will use the
other's Confidential Information for purposes other than those necessary to
directly further the purposes of this Agreement. Except as required by
applicable laws or regulations or by court order or by the rules of any national
securities exchange on which the securities of either Kendle or CSI are quoted
or listed, neither party will disclose to third parties the other's Confidential
Information without the prior written consent of the other party.

                                   SECTION 12

                   REPRESENTATIONS, WARRANTIES AND INDEMNITIES

         CSI makes the following representations and warranties for the benefit
of Kendle, as a present and ongoing affirmation of facts in existence at all
times when this Agreement or any Work Statement issued hereunder is in effect:

         12.1 NO CONFLICT. Kendle represents and warrants that it is under no
obligation or restriction, nor will it assume any such obligation or restriction
that does or would in any way interfere or conflict with, or that does or would
present a conflict of interest concerning, the work to be performed by CSI under
this Agreement and each Work Statement issued hereunder.

         12.2 OWNERSHIP RIGHTS. With respect to all subject matter, including
the CSI-Owned Software, ideas, inventions, creations, works, processes, designs
and methods, that CSI will disclose or use in its performance of the Services or
the granting of any rights under this Agreement, CSI warrants that it has the
right to make such disclosure, use and grant without liability to others. CSI
further warrants that: (i) the Product is or will be original with CSI; (ii) the
Product does not and will not infringe any U.S. patent rights, copyrights, mask
work rights, trade secret rights or other proprietary rights of others; (iii)
CSI will be the sole and exclusive owner of the Product and any Derivative Works
prepared by CSI pursuant to this Agreement and the rights granted to Kendle in
this Agreement; (iv) CSI has not previously granted and will not grant any
rights in the Product or its Derivative Works to any third party that are
inconsistent with the rights granted to Kendle herein; (v) each of CSI's
employees, consultants, contractors, partners or agents who has been or will be
involved in the development of the Product or its Derivative Works will have
signed an agreement with CSI conveying all proprietary rights in the Product to
CSI and agreeing to maintain in confidence all trade secrets embodied in the
Product and its Derivative Works; (vi) CSI has full power to enter into this
Agreement, to carry out its obligations under this Agreement and to grant the
rights granted to Kendle; and (vii) to CSI's knowledge the product provided
under this agreement does not infringe or violate any United States or foreign
patent, copyright, trademark, trade secret or other proprietary right of a third
party.



                                       9
<PAGE>   10




         12.3 CONFORMITY, PERFORMANCE, AND COMPLIANCE. CSI represents and
warrants (1) that all Deliverables shall be prepared in a workmanlike manner and
with professional diligence and skill; (2) that all Deliverables will function
on the machines and with operating systems for which they are designed for a
period of one hundred eighty (180) days after acceptance by Kendle; (3) that all
Deliverables will conform to the specifications and functions set forth in the
Work Statements relating thereto for a period of one hundred eighty (180) days
after acceptance by Kendle; and (4) that CSI will perform all work called for by
each Work Statement issued hereunder in compliance with applicable law.

         12.4 YEAR 2000 WARRANTY. CSI warrants that all Products provided
pursuant to this Agreement include, at no additional cost to Kendle, both design
and performance so that Kendle shall not experience the Product(s) abnormally
ending and/or invalid and/or incorrect results from the Product(s) in the
operation of said Product(s) prior to, during and after the Year 2000, and that
the Product(s) shall be otherwise "Year 2000 Compliant". "Year 2000 Compliant"
means the Product(s) is capable of recording and maintaining all dates in a
format which includes a 4-digit year representing century and year and which
will allow a date value of at least 2050. Year 2000 Compliant also means that
the Product(s) shall be designed to include, but not be limited to, date data
century recognition, mutually agreed upon calculations that accommodate same
century and multi-century formulas and date values, and date data values, and
data interface values that reflect the century. As Kendle's exclusive remedy for
a breach of this Year 2000 Warranty, CSI shall promptly modify, repair or
replace the Product(s) at no additional charge so as to provide Kendle with
Product(s) which conform to the Warranty; or, if CSI is unsuccessful after
utilizing its best efforts within a reasonable time, refund all fees paid by
Kendle pursuant to this Agreement upon return of said defective Product(s) to
Vendor.

         12.5     CSI'S INFRINGEMENT INDEMNITY AND DUTY TO CORRECT.

                  12.5.1 Infringement Indemnity. CSI will, at its expense and at
         Kendle's request defend any claim or action brought against Kendle, and
         Kendle's subsidiaries, affiliates, directors, officers, employees,
         agents and independent contractors, to the extent it is based on a
         claim that a Product provided under this Agreement infringes or
         violates any United States patent, copyright, trademark, trade secret
         or other proprietary right of a third party, and CSI will indemnify and
         hold Kendle harmless from and against any costs, damages and fees
         reasonably incurred by Kendle, including but not limited to fees of
         attorneys and other professionals, that are attributable to such claim
         or action; provided, however, that:

                  (i) Kendle gives CSI reasonably prompt notice in writing of
                  any such claim or action and permits CSI, through counsel of
                  its choice, to answer the charge of infringement and defend
                  such claim or action;

                  (ii) Kendle provides CSI information, assistance and
                  authority, at CSI's expense, to enable CSI to defend such
                  claim or action; and



                                       10
<PAGE>   11



                  (iii) CSI will not be responsible for any settlement made by
                  Kendle without CSI's written permission. CSI may not settle
                  any claim or action on Kendle's behalf without Kendle's
                  written permission and in the event Kendle and CSI agree to
                  settle a claim or action, CSI agrees not to disclose the
                  settlement nor to permit the party claiming infringement to
                  disclose the settlement without first obtaining Kendle's
                  written permission.

                  12.4.2 Duty to Correct. If a Product becomes or is likely to
         become the subject of a claim or action covered by Section 12.5.1, CSI
         will, at CSI's option and expense: (i) procure for Kendle the past
         right to make, use and sell and the future right to continue to make,
         use and sell the Product; (ii) replace or modify the Product to make
         such non-infringing, provided that the same function is performed by
         the replacement or modified Product to Kendle's reasonable
         satisfaction; or (iii) if the past and future rights to continue to
         make, use and sell cannot be procured or the Product cannot be replaced
         or modified at reasonable expense, reimburse Kendle for the total
         amount paid under this Agreement for such Product.

                  12.5.3 Exceptions. CSI shall have no liability under this
         Section 12.5 for any claim or action where: (i) infringement is
         attributable to CSI's incorporation of Kendle-supplied Specifications,
         software, information, devices, parts or designs into the Product; and
         (ii) such claim or action would have been avoided but for the
         combination, operation, or use of the Product with such item(s)
         supplied by Kendle.

         12.6     KENDLE'S INFRINGEMENT INDEMNITY AND DUTY TO CORRECT.

                 12.6.1 Infringement Indemnity. Kendle will, at its expense and
         at CSI's request defend any claim or action brought against CSI, and
         CSI's affiliates, directors, officers, employees, agents and
         independent contractors, to the extent it is based on a claim that the
         Kendle supplied specifications, software, information, devices, parts
         or designs incorporated into a Product infringes or violates any United
         States patent, copyright, trademark, trade secret or other proprietary
         right of a third party, and Kendle will indemnify and hold CSI harmless
         from and against any costs, damages and fees reasonably incurred by
         CSI, including but not limited to fees of attorneys and other
         professionals, that are attributable to such claim or action; provided
         however that:

                  (i) CSI gives Kendle reasonably prompt notice in writing of
                  any such claim or action and permits Kendle, through counsel
                  of its choice, to answer the charge of infringement and defend
                  such claim or action;

                  (ii) CSI provides Kendle information, assistance and
                  authority, at Kendle's expense, to enable Kendle to defend
                  such claim or action; and



                                       11
<PAGE>   12



                   (iii) Kendle will not be responsible for any settlement made
                   by CSI without Kendle's written permission. Kendle may not
                   settle any claim or action on CSI's behalf without CSI's
                   written permission and in the event Kendle and CSI agree to
                   settle a claim or action, Kendle agrees not to disclose the
                   settlement nor to permit the party claiming infringement to
                   disclose the settlement without first obtaining CSI's written
                   permission.

                   12.6.2 Exceptions. Kendle shall have no liability under this
          Section 12.6 for any claim or action where: (i) infringement is
          attributable to CSI-Owned Software, CSI-supplied Specifications,
          information, devices, parts or designs into a Product; and (ii) such
          claim or action would have been avoided but for the combination,
          operation, or use of the Product with such item(s) supplied by CSI.

          12.7 DISCLAIMERS AND LIMITATIONS. EXCEPT AS EXPRESSLY PROVIDED IN THIS
  SECTION 12, CSI MAKES NO WARRANTIES WHATSOEVER, EITHER EXPRESS OR IMPLIED,
  REGARDING ANY PRODUCT OR SERVICE HEREUNDER AND CSI FURTHER DISCLAIMS ANY
  IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR ANY PARTICULAR PURPOSE.
  IN NO EVENT SHALL EITHER PARTY BE LIABLE TO THE OTHER FOR ANY INDIRECT,
  INCIDENTAL, SPECIAL OR CONSEQUENTIAL DAMAGES.

                                   SECTION 13

                              TERM AND TERMINATION

          13.1 TERM OF AGREEMENT. This Agreement shall be effective upon the
  date specified at the beginning hereof and shall remain in force for a period
  of four (4) years, unless otherwise terminated as provided herein. However,
  this Agreement shall continue to remain in effect with respect to any Work
  Statements already issued hereunder at the time of such termination, until
  such Work Statements are themselves terminated and performance thereunder is
  completed.

          13.2 TERMINATION OF WORK STATEMENTS. Each Work Statement will identify
  points, if any, within each phase whereby Kendle and/or CSI may terminate the
  Work Statement. Such Work Statements shall also identify the consequences of
  such termination. In no event, however, shall the termination of a Work
  Statement (other than as a result of an uncured breach thereof by CSI) reduce
  Kendle's Annual Minimum payment obligation hereunder; provided, however, that
  payments made by Kendle under a Work Statement prior to termination may be
  applied against Kendle's Annual Minimum payment obligation.

          13.3 TERMINATION FOR CAUSE. This Agreement shall terminate in the
  event that either party defaults in the performance or observance of any of
  the material terms, covenants or conditions to be performed or observed by it
  under this Agreement and such default is not cured within thirty (30) days
  after written notice thereof has been given by the other party. Kendle may
  terminate this 


                                       12
<PAGE>   13

  Agreement for cause in the event that a competitor(s) of Kendle identified on
  Exhibit A owns, directly or indirectly: (i) if CSI shares are not publicly
  traded, any of CSI's issued and outstanding capital stock; and (ii) if CSI
  shares are publicly traded, five percent (5%) or more of CSI's issued and
  outstanding capital stock. In addition, Kendle may terminate this Agreement
  for cause if for any calendar year during the term of this Agreement more than
  thirty percent (30%) of CSI's annual gross revenues from operations are
  obtained from the provision of services and/or sale of products unrelated to
  the health care industry.

          13.4 TERMINATION FOR CONVENIENCE. At any time after July 20, 2000,
  Kendle may terminate this Agreement for convenience by delivering written
  notice of termination to CSI. Unless CSI agrees otherwise, termination of this
  Agreement shall take effect no earlier than six (6) months after the date that
  CSI receives the written notice from Kendle. Kendle's Annual Minimum payment
  obligation shall be pro-rated through the effective date of the termination.

          13.5 SURVIVAL. Except as may be provided within a Work Statement, in
  the event of any termination of this Agreement, Sections 10, 11, and 14 hereof
  shall survive and continue in effect and shall inure to the benefit of and be
  binding upon the parties and their legal representatives, heirs, successors,
  and assigns.

          13.6 CALL RIGHTS. In addition to any other rights or remedies that CSI
  may have under this Agreement, at law or in equity, upon and at any time or
  times after CSI's termination of this Agreement under Section 13.3 above due
  to Kendle's uncured default CSI shall have the right to call for repurchase
  all or any portion of the shares of CSI stock owned by Kendle at a per share
  price equal to the per share price paid by Kendle for such CSI stock.

          13.7 PUT RIGHTS. In addition to any other rights or remedies that
  Kendle may have under this Agreement, at law or in equity, upon and at any
  time or times after Kendle's termination of this Agreement under Section 13.3
  above due to CSI's uncured default Kendle shall have the right to put for
  repurchase all or any portion of the shares of CSI stock owned by Kendle at a
  per share price equal to the per share price paid by Kendle for such CSI
  stock. Notwithstanding any provision to the contrary hereunder, Kendle's
  rights under this Section 13.7 shall automatically expire upon the date of any
  public offering by CSI of its securities pursuant to an underwritten
  registration.

                                   SECTION 14

                                  MISCELLANEOUS

          14.1 FORCE MAJEURE. Either party shall be excused from delays in
  performing or from its failure to perform hereunder to the extent that such
  delays or failures result from causes beyond the reasonable control of such
  party (excluding delays due to loss of employees, strikes or other work
  stoppages); provided that, in order to be excused from delay or failure to
  perform, such party must act diligently to remedy the cause of such delay or
  failure. Upon an excused delay the parties shall 


                                       13
<PAGE>   14

  equitably adjust Kendle's Annual Minimum payment obligation and the timetables
  and fees under outstanding Work Statements.

          14.2 NO AGENCY. CSI, in rendering performance under Work Statements
  issued hereunder from time to time, is acting solely as an independent
  contractor. Kendle does not undertake by this Agreement or otherwise to
  perform any obligation of CSI, whether by regulation or contract. In no way is
  CSI to be construed as the agent or to be acting as the agent of Kendle in any
  respect, any other provisions of this Agreement or any Work Statements issued
  hereunder notwithstanding.

          14.3 MULTIPLE COUNTERPARTS. This Agreement may be executed in several
  counterparts, all of which taken together shall constitute one single
  Agreement between the parties.

          14.4 SECTION HEADINGS; EXHIBITS. The section and subsection headings
  used herein are for reference and convenience only, and shall not enter into
  the interpretation hereof. The exhibits referred to herein and attached
  hereto, or to be attached hereto, including all Work Statements issued
  hereunder from time to time, are incorporated herein to the same extent as if
  set forth in full herein.

          14.5 REQUIRED APPROVALS. Where agreement, approval, acceptance, or
  consent by either party is required by any provision of this Agreement, such
  action shall not be unreasonably delayed or withheld.

          14.6 NO WAIVER. No delay or omission by either party hereto to
  exercise any right or power occurring upon any noncompliance or default by the
  other party with respect to any of the terms of this Agreement shall impair
  any such right or power or be construed to be a waiver thereof. A waiver by
  either of the parties hereto of any of the covenants, conditions, or
  agreements to be performed by the other shall not be construed to be a waiver
  of any succeeding breach thereof or of any covenant, condition, or agreement
  herein contained. Unless stated otherwise, all remedies provided for in this
  Agreement shall be cumulative and in addition to and not in lieu of any other
  remedies available to either party at law, in equity, or otherwise.

          14.7 AUTHORITY OF CSI. CSI has the sole right and obligation to
  supervise, manage, contract, direct, procure, perform, or cause to be
  performed all work to be carried out by CSI hereunder unless otherwise
  provided herein.

          14.8 GOVERNING LAW AND DISPUTE RESOLUTION. This Agreement shall be
  governed by and construed in accordance with the laws of the State of Ohio.
  Any and all disputes arising out of or in connection with the execution,
  interpretation, performance, or non-performance of this Agreement or any
  agreement or other instrument between, involving or affecting the parties
  (including the validity, scope and enforceability of this arbitration clause),
  shall be submitted to and resolved by arbitration. The arbitration shall be
  conducted pursuant to the terms of the Federal Arbitration Act and the
  Commercial Arbitration Rules of the American Arbitration Association. The
  arbitration shall be conducted by three arbitrators, who shall be appointed
  pursuant to the rules of the American Arbitration Association. Either party
  may notify the other 


                                       14
<PAGE>   15

  party at any time of the existence of an arbitrable controversy by certified
  mail and shall attempt in good faith to resolve their differences within
  fifteen (15) days after the receipt of such notice. If the dispute cannot be
  resolved within the fifteen day period, either party may file a written demand
  for arbitration with the American Arbitration Association. The determination
  of the arbitrators shall be final and binding on the parties. The place of
  arbitration shall be Cincinnati, Ohio. Judgment upon the award rendered by the
  arbitrators may be entered in any court having jurisdiction.

          14.9 EMPLOYEES. During the term of this Agreement and for a period of
  two years thereafter, Kendle shall not: (i) hire or engage any current or
  former employees or independent contractors of CSI; nor (ii) knowingly
  solicit, entice, or persuade any employees or independent contractors of CSI
  to terminate their employment or engagement with CSI for any reason.
  Similarly, during the term of this Agreement and for a period of two years
  thereafter, CSI shall not (i) hire or engage any current or former employees
  or independent contractors of Kendle; nor (ii) knowingly solicit, entice, or
  persuade any employees or independent contractors of Kendle to terminate their
  employment with Kendle for any reason. Notwithstanding the foregoing, if
  Kendle terminates this Agreement under Section 13.3 above due to an uncured
  default by CSI and Kendle did not cause or contribute to such default by CSI
  nor was Kendle in default under any provision of the Agreement as of the date
  of termination of the Agreement, then Kendle may make employment offers to and
  hire those CSI employees who were working on Kendle projects as of the date of
  the Agreement's termination, or who worked on Kendle projects in the past.

          14.10. NOTICES. Under this Agreement if one party is required to give
  notice to the other, such notice shall be deemed given if mailed by U.S. mail,
  first class, postage prepaid, and addressed as follows (or as subsequently
  noticed to the other party):

  If to CSI:

                   Component Software International, Inc.
                   8118 Corporate Way, Suite 200
                   Mason, Ohio  45040-9560
                   Facsimile: (513) 573-7110
                   Attention:  Robert P. Beech, CEO

  with a copy (which shall not constitute notice) to:

                   Graydon, Head & Ritchey
                   1900 Fifth Third Center
                   511 Walnut Street
                   Cincinnati, Ohio  45202
                   Attention:  Daniel C. Heyd, Esq.





                                       15
<PAGE>   16



  If to Kendle:

                   Kendle International Inc.
                   700 Carew Tower
                   441 Vine Street
                   Cincinnati, Ohio  45202
                   Facsimile: (513) 381-5870
                   Attention:  Timothy M. Mooney, CFO

  with a copy (which shall not constitute notice) to:

                   Kendle International Inc.
                   700 Carew Tower
                   441 Vine Street
                   Cincinnati, Ohio  45202
                   Facsimile: (513) 381-5870
                   Attention:  Paul F. Ritter, Esq.

  with a copy (which shall not constitute notice) to:

                   Keating, Muething & Klekamp, P.L.L.
                   1800 Provident Tower
                   One East Fourth Street
                   Cincinnati, Ohio  45202
                   Attention:  Edward E. Steiner, Esq.

          14.11. NO ASSIGNMENT. Neither party may, without the prior written
  consent of the other party, assign or transfer this Agreement or any
  obligation incurred hereunder, except by merger, reorganization,
  consolidation, or sale of all or substantially all of such party's assets and
  except that Kendle may assign this Agreement to a wholly owned (directly or
  indirectly) subsidiary of Kendle upon at least seven (7) business days' prior
  written notice to CSI. Any attempt to do so in contravention of this Section
  shall be void and of no force and effect.

          14.12 ENTIRE AGREEMENT. This Agreement and the Schedules and Exhibits
  annexed hereto, together with the Work Statements issued from time to time
  hereunder, constitutes the entire agreement between the parties.

          14.13 COUNTERPARTS; EXECUTION. This Agreement may be executed in as
  many counterparts as may be required, and each such counterpart hereof shall
  be deemed to be an original instrument, but all such counterparts together
  shall constitute but a single agreement. This Agreement shall be deemed to
  have been executed at the time when and location at which the last signature
  of any of the parties is affixed hereto or to any counterpart hereof.




                                       16
<PAGE>   17



          IN WITNESS THEREOF, Kendle and CSI have caused this Agreement to be
  signed and delivered by their duly authorized officers, all as of the date
  first hereinabove written.

                                     COMPONENT SOFTWARE
                                     INTERNATIONAL, INC.


                                     By: /s/ Robert P. Beech
                                        -------------------------
                                     Title: President and CEO
                                           ----------------------

                                     KENDLE INTERNATIONAL INC.


                                     By: /s/ Timothy M. Mooney
                                        -------------------------
                                     Title: Vice President and CFO
                                           ----------------------


                                       17

<PAGE>   1
                                                                    Exhibit 10.7


                           AMENDMENT NO. FIVE TO LEASE


         This Amendment No. Five to Lease (the "Amendment No. 5"), made
effective this 16th day of February, 1999, is by and between CAREW REALTY, INC.
("Lessor"), a Delaware corporation, whose address is c/o Belvedere Corporation,
500 Carew Tower, 441 Vine Street, Cincinnati, Ohio 45202, and KENDLE
INTERNATIONAL INC. (formerly KENDLE RESEARCH ASSOCIATES) ("Lessee"), whose
address is Suite 700 Carew Tower, 441 Vine Street, Cincinnati, Ohio 45202.

                              W I T N E S S E T H :

         WHEREAS, effective as of December 9, 1991, Lessor and Lessee entered
into a Lease (the "Lease") with respect to approximately 21,694 rentable square 
feet of space on the 6th and 7th floors of the Carew Tower Building (the 
"Building") located at 441 Walnut Street, Cincinnati, Ohio.

         WHEREAS, the demised premises leased by Lessee in the Building at that
time encompassed 21,694 rentable square feet (the "Demised Premises").

         WHEREAS, the Commencement Date of the Lease was June 1, 1992.

         WHEREAS, effective as of December 30, 1991, Lessor and Lessee entered
into Amendment No. One To Lease which made certain amendments in and to the
Lease with regard to the construction of Lessee's Demised Premises.

         WHEREAS, effective as of March 18, 1996, Lessor and Lessee entered into
Amendment No. Two To Lease (the "Amendment No. 2") which made certain amendments
in and to the Lease, including Lessee's expansion into 6,326 square feet of
additional space for a total Demised Premises of 27,921 square feet, and such
Amendment No. 2 extended the Lease until May 31, 2003.

         WHEREAS, effective as of October 8, 1996, Lessor and Lessee entered
into Amendment No. Three To Lease (the "Amendment No. 3") which made certain
amendments in and to the Lease, including Lessee's expansion into 13,955 square
feet of space on the ninth floor of the Building for a total Demised Premises of
41,876 square feet, and such Amendment No. 3 extended the Lease until May 31,
2004.

         WHEREAS, effective as of January 29, 1997, Lessor and Lessee entered
into Amendment No. Four To Lease (the "Amendment No. 4") which made certain
amendments in and to the Lease, including Lessee's expansion into 13,620 square
feet of space on the eighth floor of the Building for a total Demised Premises
of 55,496 square feet, and such Amendment No. 4 extended the term until May 31,
2006.


<PAGE>   2




         WHEREAS, effective as of July 30, 1998, Lessee entered into a Sublease
Agreement (the "Sublease") with Cors & Bassett for 13,200 square feet of space
on the 12th floor of the Building and 3,256 square feet of space on a portion of
the 11th floor of the Building for a total sublease area of 16,456 square feet
of space (the "Sublease Space"). Lessor consented to such Sublease on August 12,
1998.

         NOW, THEREFORE, effective upon execution of this Amendment No. Five To
Lease, Lessor and Lessee hereby agree and acknowledge the following:

1.       Lessee shall expand into an additional 13,682 square feet of space on
         the fifteenth floor of the Building (the "15th Floor Expansion Space")
         and an additional 7064 square feet of space on the 11th floor of the
         Building (the 11th Floor Expansion Space") for a total Demised Premises
         of 76,242 square feet.

         Lessee shall begin paying rent on the 15th Floor Expansion Space on the
         earlier date of: (i) within forty-five (45) days of Lessor delivering
         the 15th Floor Expansion Space over to Lessee for construction of any
         interior improvements; or (ii) the date Lessee takes occupancy of the
         15th Floor Expansion Space (the "15th Floor Commencement Date").

         Lessee shall begin paying rents on the 11th Floor Expansion Space on
         the earlier date of: (i) within ninety (90) days of Lessor delivering
         the 11th Floor Expansion Space to Lessee for construction of any
         interior improvements; or (ii) the date Lessee takes occupancy of the
         11th Floor Expansion Space (the 11th Floor Commencement Date").

         Lessor anticipates delivering the 15th Floor Expansion Space to Lessee
         by July 1st, 1999, and Lessor anticipates delivering the 11th Floor
         Expansion Space to Lessee within ninety (90) days (or sooner) of
         execution of the Amendment No. 5.

2.       Commencing on the 15th Floor Commencement Date and the 11th Floor
         Commencement Date, Lessee shall lease the 15th Floor Expansion Space
         and the 11th Floor Expansion Space from Lessor on the same terms and
         conditions, including Basic Rental, as Lessee's existing Lease dated
         December 9, 1991 and as amended by Amendment No. One to Lease dated
         December 30, 1996; Amendment No. Two to Lease dated March 18, 1996;
         Amendment No. Three to Lease dated October 8, 1996 and by Amendment No.
         Four to Lease dated January 29, 1997.

3.       Lessor shall provide an improvement allowance to Lessee of $5.00 per
         square foot on the 15th Floor Expansion Space of 13,682 square feet and
         $17.00 per square foot on the 11th Floor Expansion Space. This
         allowance shall be paid within Forty-five (45) days of Lessor
         delivering the respective

<PAGE>   3


         expansion spaces over to Lessee for occupancy. Lessor, by its
         contractor, to adjust sprinkler systems in each space as necessary with
         no cost to Lessee.

4.       Lessee's contractors shall perform any and all interior improvements
         that are required by Lessee to the 15th Floor Expansion Space and the
         11th Floor Expansion Space. All plans and specifications (including but
         not limited to architectural, HVAC, electrical, plumbing and
         sprinklering) must be approved by Lessor prior to commencing any
         construction work in the respective expansion spaces.

5.       Any areas in the 11th Floor Expansion Space or the 15th Floor Expansion
         Space not already sprinklered shall be performed by Lessor's contractor
         and at Lessor's expense.

6.       Lessee shall be responsible for any "dry" sprinkler systems needed for
         the 11th Floor Expansion Space and/or the 15th Floor Expansion Space,
         as well as, any additional air- conditioning needed for the respective
         expansion spaces.

7.       On June 30, 2001 the lease agreement between Cors & Bassett and Carew
         Realty, Inc. which Lessee has assumed shall be terminated and shall
         become null and void. Commencing on July 1, 2001, Lessee shall lease
         the Cors & Bassett space of 16,456 square feet (the "Cors Space") for a
         total Demised Premises of 92,698 from Lessor on the same terms and
         conditions, including Basic Rental, as Lessee's existing Lease dated
         December 9, 1991 and as amended by Amendment No. One to Lease dated
         December 30, 1996; Amendment No. Two to Lease dated March 18, 1996;
         Amendment No. Three to Lease dated October 8, 1996 and by Amendment No.
         Four to Lease dated January 29, 1997; with the following addition now
         added to the Lease for the Cors Space of 16,456 square feet:

         "Commencing on July 1, 2001, and continuing until lease expiration,
         Lessee shall be required to pay a utility charge of $1.58 per square
         foot (the "Utility Charge") for the period from July 1, 2001 to June
         30, 2002. Each 12 month period thereafter, the Utility Charge shall
         increase by two and one-half percent (2.5%). Lessee shall be required
         to pay such Utility Charge on the first day of each calendar month with
         Lessee's rental payment.

8.       At any time after June 30, 2001, Lessee may request from Lessor, an
         improvement allowance of $5.00 per square foot on the Cors Space of
         16,456 square feet. Such allowance shall be paid by Lessor within
         forty-five (45) days after written notice from Lessee.

9.       Paragraph 36, Renewal Option, shall be changed to state that Lessee
         shall be required to provide twelve (12) months prior written notice to
         Lessor for election of either the first or second five-year renewal
         period.


<PAGE>   4



10.      Lessee and Lessor represent and warrant to each other that neither has
         dealt with any other broker or finder who shall be entitled to any
         commission or fee by reason of the execution of this Amendment, and
         each party agrees to indemnify and hold the other harmless from any
         liability or expense that the other may suffer or incur with respect to
         any claim for a commission or fee by any other broker or finder
         claiming by, through or under the other party.

11.      Lessee shall continue to pay its month-to-month rental rate on the
         existing 11th Floor space that it occupies per the letter agreement
         dated January 20, 1999.

         All other terms and conditions of the Lease as amended shall remain in
full force and effect.

         IN WITNESS WHEREOF, the undersigned have executed this Amendment No. 5
on the date set forth below.

WITNESSETH:                                 CAREW REALTY, INC.
                                            By:  Belvedere Corporation
                                                  Managing Agent


/s/ Ann M. Witti                            By /s/ Joan Hensler-Bittner
- ----------------------------                  --------------------------------
/s/ Mel Heis                                Its: V.P.                     
- ----------------------------                  --------------------------------

                                            Date: 2/16/99
                                                 -----------------------------


WITNESSETH:                                 KENDLE INTERNATIONAL INC.


/s/ Lynn L. Fields                          By /s/ Timothy M. Mooney
- ----------------------------                  --------------------------------

/s/ Evelyn LaBrier                          Its: V. P. - CFO
- ----------------------------                    ------------------------------

                                            Date: 2/15/99
                                                 -----------------------------



STATE OF OHIO                               )
                                            )  ss.
COUNTY OF HAMILTON                          )

         BE IT REMEMBERED, that on the 16th day of February, 1999, before me a
Notary Public in and for said county and state, personally appeared Carew
Realty, Inc., the corporation, which executed the foregoing instrument by Joan
M. Hensler-Bittner, the Vice President of Belvedere Corporation, Managing Agent,
who acknowledged that he/she is authorized to sign on behalf of said


<PAGE>   5


corporation, and the signing thereof to be its and his/her voluntary act and
deed.

         IN TESTIMONY WHEREOF, I have hereunto subscribed my name and affixed my
official seal on the day and year aforesaid.


                                              /s/ Patricia A. Lieurance 
                                              ------------------------------
                                              Notary Public

                                                       [SEAL]


STATE OF OHIO                               )
                                            )  ss.
COUNTY OF HAMILTON                          )

         BE IT REMEMBERED, that on the 15th day of February, 1999, before me a
Notary Public in and for said county and state, personally appeared Kendle
Research Associates, the corporation which executed the foregoing instrument by
Timothy M. Mooney, its V.P., Finance and CFO who acknowledged that he/she is
authorized to sign on behalf of said corporation, and the signing thereof to be
its and his/her voluntary act and deed.

         IN TESTIMONY WHEREOF, I have hereunto subscribed my name and affixed my
official seal on the day and year aforesaid.


                                                 /s/ Jeffery Allen Glancy 
                                                 ------------------------------
                                                 Notary Public


                                                       [SEAL]

<PAGE>   1
                                                                   Exhibit 10.13
                                      -1-



                               INDEMNITY AGREEMENT

         THIS INDEMNITY AGREEMENT ("Agreement") is made effective as of December
10, 1998 by and between KENDLE INTERNATIONAL INC., an Ohio corporation (the
"Company"), and Robert Buck (the "Indemnitee").

                                R E C I T A L S:


         A.       The Company and the Indemnitee recognize the difficulty and
expense of obtaining adequate directors' and officers' liability insurance;

         B.       The Company and the Indemnitee recognize the substantial
increase in corporate litigation in general, subjecting directors and officers
to expensive litigation risks at the same time as the availability and coverage
of liability insurance has been severely limited;

         C.       Based upon their experience as business managers, the Board of
Directors of the Company (the "Board") has concluded that, to retain and attract
talented and experienced individuals to serve as directors and officers of the
Company, it is necessary for the Company contractually to indemnify its
directors and officers with respect to claims against such directors and
officers in connection with their service to or on behalf of the Company, and
that the failure to provide such contractual indemnification could result in
great harm to the Company and the Company's shareholders;

         D.       Section 1701.13(E) ("Section 1701.13(E)") of the General
Corporation Law of Ohio, under which the Company is organized, empowers the
Company to indemnify its directors and officers by agreement and to indemnify
persons who serve, at the request of the Company, as the directors, officers,
employees or agents of other corporations or enterprises, and expressly provides
that the indemnification provided by Section 1701.13(E) is not exclusive;

         E.       The Company, after reasonable investigation prior to the date
hereof, has determined that the liability insurance coverage available to the
Company is inadequate or inordinately expensive and that the Indemnitee and
other directors or officers of the Company may not be willing to continue to
serve as directors or officers without additional protection;

         F.       The Company desires and has requested the Indemnitee to serve
or continue to serve as a director or officer of the Company; and,

         G.       The Indemnitee is willing to serve, or to continue to serve,
the Company, provided that he is furnished the indemnity provided for herein;



<PAGE>   2

                                       -2-



         NOW, THEREFORE, based upon the foregoing premises and in consideration
of the mutual covenants contained herein, the parties hereto hereby agree as
follows:

         1.       DEFINITIONS.

         1.1      Agent. For the purposes of this Agreement, "Agent" means any
person who is a director or officer of the Company; or is serving at the request
of, for the convenience of or to represent the interests of the Company as a
director, officer, manager, employee or agent of another foreign or domestic
corporation (for profit or nonprofit), partnership, limited liability company,
joint venture, trust or other enterprise (specifically including employee
benefit plans).

         1.2      Expenses. For purposes of this Agreement, "Expenses" includes
all direct costs (including, without limitation, all attorneys' fees and related
disbursements and other out-of-pocket costs) actually and reasonably incurred by
the Indemnitee in connection with the investigation, defense or appeal of a
Proceeding, as that term is defined in Section 1.4, or establishing or enforcing
a right to indemnification under this Agreement; PROVIDED, however, that
"Expenses" shall not include any judgments, fines, ERISA excise taxes or
penalties or amounts paid in settlement of a Proceeding, or prepaid retainers
for attorneys or other professionals engaged by or on behalf of the Indemnitee.

         1.3      Liability. For purposes of this Agreement, "Liability" or
"Liabilities," includes any judgment, fine, ERISA excise tax or penalty or any
amount paid, with the Company's written consent, in settlement of a Proceeding.

         1.4      Proceeding. For the purposes of this Agreement, "Proceeding"
means any threatened, pending or completed action, suit or other proceeding,
whether civil, criminal, administrative, investigative or any other type
whatsoever.

         2.       AGREEMENT TO SERVE. The Indemnitee agrees to serve and/or to
continue to serve as an Agent in the capacity the Indemnitee currently serves as
an Agent, as long as such service is mutually agreeable to Indemnitee and the
Company.

         3.       MAINTENANCE OF LIABILITY INSURANCE.

         3.1      Maintenance of Insurance. As long as the Indemnitee shall
continue to serve as an Agent and thereafter as long as the Indemnitee shall be
subject to any possible Proceeding by reason of the fact that the Indemnitee was
an Agent, the Company, subject to the provisions of Section 3.3 with respect to
the unavailability of satisfactory insurance coverage, shall promptly obtain
and/or maintain in full force and effect directors' and officers' liability
insurance ("D&O Insurance") in reasonable amounts from established and reputable
insurers. If D&O Insurance is obtained, the Company covenants that the
Indemnitee shall be named as an insured.


<PAGE>   3

                                      -3-


         3.2      Indemnitee Named as Insured. In all policies of D&O Insurance,
if any, the Indemnitee shall be named as an insured in such a manner as to
provide the Indemnitee the same rights and benefits as are accorded to the
Company's most favorably insured directors.

         3.3      Unavailability of Satisfactory Coverage. Notwithstanding the
foregoing, the Company shall have no obligation to obtain or maintain D&O
Insurance if the Company determines in good faith that such insurance is not
reasonably available, or that the premium costs for such insurance are
disproportionate to the amount of coverage provided or that the coverage
provided by such insurance is limited by exclusions so as to provide an
insufficient benefit. The failure of the Company to obtain D&O Insurance or the
decision by the Company not to obtain such coverage shall not have any
detrimental effect on the Indemnitee's rights hereunder.

         4.       MANDATORY INDEMNIFICATION.

         4.1      Third Party Actions. The Company shall indemnify the
Indemnitee when the Indemnitee is a party or is threatened to be made a party to
any Proceeding (other than an action by or in the right of the Company) by
reason of the fact that he is or was an Agent, or by reason of anything done or
not done by him in any such capacity, against any and all Expenses and
Liabilities of any type whatsoever actually and reasonably incurred by him in
connection with the investigation, defense, settlement or appeal of that
Proceeding if he acted in good faith and in a manner he reasonably believed to
be in or not opposed to the best interests of the Company, and, with respect to
any criminal action or proceeding, had no reasonable cause to believe his
conduct was unlawful. The termination of any Proceeding by judgment, order,
settlement, conviction or upon a plea of NOLO CONTENDERE or its equivalent shall
not create a presumption that the Indemnitee did not satisfy the foregoing
standard of conduct.

         4.2      Proceedings by or in the Right of the Company. The Company
shall indemnify the Indemnitee when the Indemnitee is a party or is threatened
to be made a party to any Proceeding by or in the right of the Company to
procure a judgment in its favor by reason of the fact that he is or was an
Agent, or by reason of anything done or not done by him in any such capacity,
against any amounts paid in settlement of any such proceeding and all expenses
actually and reasonably incurred by him in connection with the investigation,
defense, settlement or appeal of that Proceeding if he acted in good faith and
in a manner he reasonably believed to be in or not opposed to the best interests
of the Company; except that no indemnification under this subsection shall be
made in respect of any claim, issue or matter as to which such person shall have
been finally adjudged to be liable to the Company under the standards of the
Ohio General Corporation Law by a court of competent jurisdiction in the
performance of his duty to the Company unless and only to the extent that the
court in which such Proceeding was brought shall determine, upon application,
that, despite the adjudication of liability, but in view of all the


<PAGE>   4

                                      -4-


circumstances of the case, such person is fairly and reasonably entitled to
indemnity for such amounts which such court shall deem proper.

         4.3      Expenses or Liabilities Paid by D&O Insurance or the Trust.
Notwithstanding the foregoing, the Company shall not be obligated to indemnify
the Indemnitee for Expenses or Liabilities of any type whatsoever which have
been paid directly to, or for the benefit of, the Indemnitee by D&O Insurance or
out of any trust that may be established pursuant to Section 9 hereof. 

         5.       PARTIAL INDEMNIFICATION. If the Indemnitee is entitled under
any provision of this Agreement to indemnification by the Company for a part,
but not the total amount, of any Expenses or Liabilities of any type whatsoever
incurred by him in the investigation, defense, settlement or appeal of a
Proceeding, the Company shall indemnify the Indemnitee only for such amount to
which the Indemnitee is entitled as indemnification hereunder.

         6.       MANDATORY ADVANCEMENT OF EXPENSES. Subject to Sections 7 and
10 hereof, the Company shall advance all Expenses incurred by the Indemnitee in
connection with the investigation, defense, settlement or appeal of any
Proceeding to which the Indemnitee is a party or is threatened to be made a
party by reason of the fact that the Indemnitee is or was an Agent, or in
connection with any action brought by the Indemnitee to establish or enforce a
right to indemnification under this Agreement pursuant to Section 8 hereof, in
advance of the final disposition thereof. Indemnitee hereby undertakes: (x) to
repay all such amounts advanced if (but only if) it shall be proved by clear and
convincing evidence in a court of competent jurisdiction that his action or
failure to act involved an act or omission undertaken with deliberate intent to
cause injury to the Company or undertaken with reckless disregard for the best
interests of the Company; and (y) to cooperate reasonably with the Company in
connection with such Proceeding. The advances to be made hereunder shall be paid
by the Company to or for the benefit of the Indemnitee within twenty (20) days
following delivery of a written request therefor, accompanied by true and
complete copies of invoices therefor, by the Indemnitee to the Company.

         7.       NOTICE AND OTHER INDEMNIFICATION PROCEDURES.

         7.1      Notice to Company. Promptly after receipt by the Indemnitee of
notice of the commencement or the threatened commencement of any Proceeding, the
Indemnitee shall notify the Company of such commencement or threatened
commencement. The Indemnitee shall also provide the Company such information and
cooperation as the Company from time to time may reasonably request and as shall
reasonably be within the Indemnitee's power to provide. The Company shall have
no obligation to indemnify the Indemnitee under this Agreement if (but only if)
the Indemnitee's delay or failure to provide notice, information or cooperation
as required under this Section 7.1 results in a material impairment of the
Company's ability to defend the Proceeding or in the loss of coverage under any
applicable insurance policy.



<PAGE>   5
                                      -5-


         7.2      Notice to Insurance Carriers. If the Company has any
applicable insurance policy in effect at the time it receives notice pursuant to
Section 7.1 of the commencement or threatened commencement of a Proceeding, the
Company shall give prompt notice thereof to the insurer(s) in accordance with
the procedure set forth in the respective policies. The Company shall thereafter
take all necessary or desirable action to cause such insurers to pay, on behalf
of the Indemnitee, all amounts payable as a result of such Proceeding in
accordance with the terms of such policies.

         7.3      Choice of Counsel. In the event the Company shall be obligated
to advance the Expenses of any Proceeding against the Indemnitee, the Company
shall be entitled, in lieu thereof, to assume the defense of such proceeding
upon the delivery to the Indemnitee of written notice of the Company's election
to do so, which notice shall contain the name, address and phone number of
counsel engaged by the Company to handle such defense and confirmation that the
Company has undertaken to pay that counsel's reasonable fees and expenses
therefor. After delivery of such notice, the Company shall not be liable to the
Indemnitee under this Agreement for any fees or expenses of counsel for the
Indemnitee (other than the counsel engaged by the Company) subsequently incurred
by the Indemnitee with respect to the same Proceeding; PROVIDED, however, that
the fees and expenses of such counsel for the Indemnitee shall be at the expense
of the Company if () the employment of separate counsel by the Indemnitee has
been previously authorized by the Company, or () the Indemnitee shall have
reasonably concluded, and either the Company shall have agreed, or independent
counsel (as defined herein) shall have determined, that there may be a conflict
of interest between the Company and the Indemnitee in the conduct of any such
defense; and FURTHER PROVIDED, however, that, the Indemnitee's counsel shall
have been approved by any carrier of an applicable insurance policy if required
under the terms of that policy. As used in this Section 7.3, "independent
counsel" shall mean counsel selected and compensated by the Company, and
reasonably approved by the Indemnitee, to determine whether a conflict of
interest may exist, which counsel shall not represent the Company, the
Indemnitee or any other party to the Proceeding for which indemnification is
sought. Independent counsel shall be selected promptly following notice from the
Indemnitee to the Company of the Indemnitee's belief that a conflict of interest
may exist. Nothing herein shall limit the right of the Indemnitee to employ
counsel at the Indemnitee's sole expense.

         8.       DETERMINATION OF RIGHT TO INDEMNIFICATION.

         8.1      Successful Defense. To the extent the Indemnitee has been
successful on the merits or otherwise in defense of any Proceeding referred to
in Sections 4.1 or 4.2 hereof or in the defense of any claim, issue or matter
described therein, the Company shall indemnify the Indemnitee against Expenses
actually and reasonably incurred by him in connection with the investigation,
defense or appeal of such Proceeding.




<PAGE>   6
                                      -6-


         8.2      Satisfaction of Standard of Conduct. In the event that Section
8.1 is inapplicable, (i) indemnification under Section 4.1 hereof shall be made
by the Company only upon a determination in accordance with this Section 8 that
the Indemnitee is entitled to indemnification hereunder, and (ii)
indemnification under Section 4.2 shall be made, if at all, in accordance with
the procedure set forth in Section 4.2. If the Indemnitee believes, upon the
disposition of any Proceeding described in Section 4.1 (whether by judgment,
settlement or otherwise), that the Indemnitee is entitled to indemnification
pursuant to this Agreement, the Indemnitee shall make written demand therefor
upon the Company. The Company shall indemnify the Indemnitee in accordance with
such demand unless, within forty-five (45) days after receipt of the
Indemnitee's demand, the Company notifies the Indemnitee that it has determined
that the Indemnitee has not met the applicable standard of conduct required to
entitle the Indemnitee to such indemnification (the "Notice of Denial"). The
Notice of Denial shall set forth, in reasonable detail, the basis for such
determination by the Company and the name of counsel selected by the Board
pursuant to Section 8.3.2 hereof.

         8.3      Forum for Determination of Satisfaction of Standard of
Conduct. Provided the Indemnitee notifies the Company of his choice of forum
within thirty (30) days after the receipt of a Notice of Denial, the Indemnitee
shall be entitled to select one of the following forums to determine whether he
met the applicable standard of conduct specified in Section 4.1 and is therefore
entitled to indemnification under this Agreement:

         8.3.1    Quorum of Disinterested Directors. A vote of a majority of a
         quorum (more than fifty percent (50%)) of the Board consisting of
         directors who are not parties to the Proceeding for which
         indemnification is being sought, based upon written submissions by the
         Company and the Indemnitee and, if the Indemnitee or directors so
         request, an oral presentation by the Indemnitee and by such other
         persons as such directors may request; PROVIDED, however, that the
         Indemnitee shall not have the right to be present during such
         directors' deliberations nor during presentations made to such
         directors by any person other than the Indemnitee;

         8.3.2    Counsel. Legal counsel selected by the Board (other than
         counsel to any party to the Proceeding for which indemnification is
         sought), and reasonably approved by the Indemnitee, which counsel shall
         make such determination in a written opinion based upon written
         submissions by the Company and the Indemnitee and responses to such
         questions as that counsel may have in such form as that counsel may
         request;

         8.3.3    Arbitration Panel. A majority vote of a panel of three
         arbitrators, one of whom is selected by the first two arbitrators so
         selected, which arbitration shall be conducted in accordance with the
         rules of the American Arbitration Association and such rules of
         procedure as may be established by the panel; or



<PAGE>   7
                                      -7-


         8.3.4    Court. The court in which the Proceeding is or was pending, in
         accordance with such rules of procedure as may be applicable to or
         established by that court.

         8.4      Submission to Forum. As soon as practicable, and in no event
later than thirty (30) days after the Indemnitee's written notice to the Company
of the Indemnitee's choice of forum pursuant to Section 8.3 above, the Company
shall, at its expense, submit to the selected forum its claim that the
Indemnitee is not entitled to indemnification. The Indemnitee shall be afforded
an adequate opportunity to defend against that claim. A presumption shall exist
that the Indemnitee is entitled to indemnification hereunder, and the Company
shall indemnify the Indemnitee unless the Company shall prove to the selected
forum, by clear and convincing evidence, that the Indemnitee has not met the
applicable standard of conduct required to entitle the Indemnitee to such
indemnification. The decision of the selected forum shall constitute a binding
and final adjudication between the Company and the Indemnitee as to the
Indemnitee's right to indemnification under Section 4.1 of this Agreement.

         8.5      Expenses of Determination. Notwithstanding any other provision
in this Agreement to the contrary, the Company shall indemnify the Indemnitee
against all Expenses incurred by the Indemnitee in connection with any hearing
or proceeding under this Section 8 involving the Indemnitee and against all
Expenses incurred by the Indemnitee in connection with any other Proceeding
between the Company and the Indemnitee involving the interpretation or
enforcement of the rights of the Indemnitee under this Agreement unless the
Company shall be deemed the prevailing party in any such proceeding.

         9.       INDEMNIFICATION TRUST AGREEMENT. In order to secure the
obligations of the Company to advance to the Indemnitee certain amounts under
Section 6 hereof, the Company may establish a trust fund naming the Indemnitee
as a beneficiary (in addition to all other directors, officers and other agents
with whom the Company enters into Indemnity Agreements, whether before, on, or
after the date hereof). The Indemnitee shall not seek any amount from the Trust,
if established, (i) unless entitled to an advance of Expenses pursuant to this
Agreement and (ii) unless and until the Indemnitee has made demand for payment
of Expenses pursuant to Section 6 hereof and, after twenty (20) days, the
Company has failed to advance such Expenses. The Indemnitee shall not be
entitled to receive a reimbursement or advance from the Trust, if established,
for a liability or other amount not expressly covered by Section 6 hereof.

         10.      EXCEPTIONS. Notwithstanding any other provision herein to the
contrary, the Company shall not be obligated pursuant to the terms of this
Agreement:

         10.1     Claims Initiated by the Indemnitee. To indemnify or advance
Expenses to the Indemnitee with respect to proceedings or claims initiated or
brought voluntarily by the Indemnitee and not by way of defense, except with
respect to proceedings brought to establish or enforce a right to
indemnification under this Agreement; or



<PAGE>   8
                                      -8-


         10.2     The Company Prevails in Action to Enforce or Interpret
Agreement. To indemnify the Indemnitee for any Expenses incurred by the
Indemnitee with respect to any Proceeding instituted by the Indemnitee to
enforce or interpret this Agreement, if the Company is deemed to be the
prevailing party in such proceeding; or

         10.3     Unauthorized Settlements. To indemnify the Indemnitee for any
amounts paid in settlement of a Proceeding unless the Company expressly consents
in writing to such settlement; or

         10.4     Failure to Settle Proceeding. To indemnify the Indemnitee for
Liabilities in excess of the total amount at which settlement reasonably could
have been made, or for any Expenses incurred by the Indemnitee following the
time such settlement reasonably could have been effected, if the Indemnitee
shall have unreasonably delayed, refused or failed to enter into a settlement of
any Proceeding (or investigation or appeal thereof) recommended in good-faith,
in writing, by the Company.

         11.      NO RESTRICTION OF OTHER INDEMNIFICATION RIGHTS. The Company
shall not adopt any amendment to its Articles of Incorporation or Regulations,
the effect of which would be to deny, diminish or encumber the Indemnitee's
rights to indemnity pursuant to the Articles of Incorporation, the Regulations,
the Ohio General Corporation Law or any other applicable law as applied to any
act or failure to act occurring in whole or in part prior to the date (the
"Effective Date") upon which the amendment shall apply only to acts or failures
to act occurring entirely after the Effective Date thereof, unless the
Indemnitee shall have voted in favor of the amendment as a director or holder of
record of the Company's common stock, as the case may be.

         12.      MERGER OR CONSOLIDATION. In the event that the Company shall
be a constituent corporation in a merger, consolidation or other reorganization,
the Company, if it shall not be the surviving, resulting or acquiring
corporation therein, shall require, as a condition thereto, that the surviving,
resulting, or acquiring corporation agree to indemnify the Indemnitee to the
full extent provided in this Agreement and to adopt and assume the Company's
obligations under this Agreement. Whether or not the Company is the surviving,
resulting or acquiring corporation in any such transaction, the Indemnitee shall
also stand in the same position under this Agreement as he would have with
respect to the Company if its separate existence had continued.

         13.      NON-EXCLUSIVITY. The provisions for indemnification and
advancement of expenses set forth in this Agreement shall not be deemed
exclusive of any other rights which the Indemnitee may have under any provision
of law, the Company's Articles of Incorporation or Regulations, the vote of the
Company's shareholders or disinterested directors, other agreements or
otherwise, whether as to actions in his official capacity or actions in another
capacity while 


<PAGE>   9

                                      -9-


occupying his position as an Agent. The Indemnitee's rights hereunder shall
continue after the Indemnitee has ceased acting as an Agent and shall inure to
the benefit of the successors, heirs, executors, administrators, estates, legal
representatives and assigns of the Indemnitee.

         14.      INTERPRETATION OF AGREEMENT. It is understood that the parties
hereto intend this Agreement to be interpreted and enforced so as to provide
indemnification to the Indemnitee to the fullest extent now or hereafter
permitted by law; PROVIDED, however, that no change in any applicable law,
statute or rule which has the effect of narrowing the right of an Ohio
corporation to indemnify any Agent shall, unless otherwise required thereby,
affect this Agreement or the parties' rights or obligations hereunder.

         15.      HEADINGS. Descriptive headings in this Agreement are solely
for convenience and shall not control or affect the construction or
interpretation of any provision herein.

         16.      SEVERABILITY. If any provision or provisions of this Agreement
shall be held to be invalid, illegal or unenforceable for any reason whatsoever,
(i) the validity, legality and enforceability of the remaining provisions of the
Agreement (including without limitation, all portions of any paragraphs of this
Agreement containing any such provision held to be invalid, illegal or
unenforceable, that are not themselves invalid, illegal or unenforceable) shall
not in any way be affected or impaired thereby, and (ii) to the fullest extent
possible, the provisions of this Agreement (including, without limitation, all
portions of any paragraph of this Agreement containing any such provision held
to be invalid, illegal or unenforceable, that are not themselves invalid,
illegal or unenforceable) shall be construed so as to give effect to the intent
manifested by the provision held invalid, illegal or unenforceable and to give
effect to Section 13 hereof.

         17.      MODIFICATION AND WAIVER. No supplement, modification or
amendment of this Agreement shall be binding unless executed in writing by both
of the parties hereto. No waiver of any of the provisions of this Agreement
shall be deemed or shall constitute a waiver of any other provision hereof
(whether or not similar) nor shall such waiver constitute a continuing waiver.

         18.      SUCCESSORS AND ASSIGNS. The terms of this Agreement shall
bind, and shall inure to the benefit of, the successors, heirs, executors,
administrators, estates, legal representatives and assigns of the parties
hereto; PROVIDED, however, that the Indemnitee may not delegate his duties
hereunder; and PROVIDED FURTHER, that no assignment shall obligate the Company
to provide any indemnification with respect to the actions or failures to act of
any person other than the Indemnitee specifically named herein.

         19.      NOTICES. All notices, requests, demands, waivers and other
communications required or permitted to be given under this Agreement shall be
in writing and shall be deemed to have been given when delivered personally by
overnight carrier or by telecopy with telephonic



<PAGE>   10

                                      -10-


confirmation of receipt or by two (2) business days after being deposited in the
U.S. mail, certified or registered, return receipt requested with postage
prepaid, and addressed to the party to whom such notice, request, demand, waiver
or other communication is to be given as follows, or at such other address as
either party shall designate by notice to the other party pursuant to this
section:

         The Company:               Kendle International Inc.
                                    700 Carew Tower
                                    Cincinnati, Ohio 45202
                                    Attention: Candace Kendle
                                               Chairman of the Board
                                               and Chief Executive Officer

         with a required copy to:   Paul F. Ritter, Esq.
                                    700 Carew Tower
                                    Cincinnati, Ohio 45202

         Indemnitee:                Robert Buck
                                    Cintas Corp.
                                    6800 Cintas Blvd.
                                    P.O. Box 625737
                                    Cincinnati, Ohio 45262-5737

         20.      GOVERNING LAW. This Agreement, and the rights and duties of
the parties hereto under this Agreement, shall be governed exclusively by and
construed in accordance with the laws of the State of Ohio, as applied to
contracts between Ohio residents entered into and to be performed entirely
within Ohio.

         21.      CONSENT TO JURISDICTION. Except as expressly provided in
Section 8 hereof, the Company and the Indemnitee each hereby irrevocably consent
to the jurisdiction of the courts of the State of Ohio for all purposes in
connection with any action or proceeding which arises out of or relates to this
Agreement and agree that any action instituted under this Agreement shall be
brought only in the state courts of the State of Ohio.

         22.      COUNTERPARTS. This Agreement may be executed in two (2) or
more counterparts, and by each party on separate counterparts, each of which
counterparts shall be deemed an original, but all of which counterparts taken
together shall be one and the same document.

         23.      PUBLIC POLICY DETERMINATIONS. The Company and the Indemnitee
acknowledge that, in certain circumstances, federal law or applicable public
policy may prohibit the Company 


<PAGE>   11
                                      -11-


from indemnifying the Indemnitee under this Agreement or otherwise. The
Indemnitee understands and acknowledges that the Company has undertaken, and may
in the future be required to undertake, to submit the question of the Company's
right under public policy to indemnify the Indemnitee to a court of appropriate
jurisdiction under certain circumstances, unless, in the opinion of counsel,
such matter has been settled by controlling precedent, and that such
determination shall be binding on the Company and the Indemnitee.

(remainder of page intentionally blank)




<PAGE>   12

                                      -12-



         The parties hereto have entered into this Indemnity Agreement effective
as of the date first above written.


                                   KENDLE INTERNATIONAL INC.


                                   By: /s/ Candace Kendle
                                       -------------------------------------- 
                                       Candace Kendle,
                                       Chairman of the Board
                                       and Chief Executive Officer



                                   INDEMNITEE:

                                   /s/ Robert Buck
                                   ------------------------------------------ 
                                   Robert Buck








<PAGE>   1

                                                                   EXHIBIT 10.14

                                      -1-



                               INDEMNITY AGREEMENT

         THIS INDEMNITY AGREEMENT ("Agreement") is made effective as of December
10, 1998 by and between KENDLE INTERNATIONAL INC., an Ohio corporation (the
"Company"), and Mary Beth Price (the "Indemnitee").


                                R E C I T A L S:


         A.       The Company and the Indemnitee recognize the difficulty and
expense of obtaining adequate directors' and officers' liability insurance;

         B.       The Company and the Indemnitee recognize the substantial
increase in corporate litigation in general, subjecting directors and officers
to expensive litigation risks at the same time as the availability and coverage
of liability insurance has been severely limited;

         C.       Based upon their experience as business managers, the Board of
Directors of the Company (the "Board") has concluded that, to retain and attract
talented and experienced individuals to serve as directors and officers of the
Company, it is necessary for the Company contractually to indemnify its
directors and officers with respect to claims against such directors and
officers in connection with their service to or on behalf of the Company, and
that the failure to provide such contractual indemnification could result in
great harm to the Company and the Company's shareholders;

         D.       Section 1701.13(E) ("Section 1701.13(E)") of the General
Corporation Law of Ohio, under which the Company is organized, empowers the
Company to indemnify its directors and officers by agreement and to indemnify
persons who serve, at the request of the Company, as the directors, officers,
employees or agents of other corporations or enterprises, and expressly provides
that the indemnification provided by Section 1701.13(E) is not exclusive;

         E.       The Company, after reasonable investigation prior to the date
hereof, has determined that the liability insurance coverage available to the
Company is inadequate or inordinately expensive and that the Indemnitee and
other directors or officers of the Company may not be willing to continue to
serve as directors or officers without additional protection;

         F.       The Company desires and has requested the Indemnitee to serve
or continue to serve as a director or officer of the Company; and,

         G.       The Indemnitee is willing to serve, or to continue to serve,
the Company, provided that she is furnished the indemnity provided for herein;


<PAGE>   2

                                      -2-


         NOW, THEREFORE, based upon the foregoing premises and in consideration
of the mutual covenants contained herein, the parties hereto hereby agree as
follows:

         1.       DEFINITIONS.

         1.1      Agent. For the purposes of this Agreement, "Agent" means any
person who is a director or officer of the Company; or is serving at the request
of, for the convenience of or to represent the interests of the Company as a
director, officer, manager, employee or agent of another foreign or domestic
corporation (for profit or nonprofit), partnership, limited liability company,
joint venture, trust or other enterprise (specifically including employee
benefit plans).

         1.2      Expenses. For purposes of this Agreement, "Expenses" includes
all direct costs (including, without limitation, all attorneys' fees and related
disbursements and other out-of-pocket costs) actually and reasonably incurred by
the Indemnitee in connection with the investigation, defense or appeal of a
Proceeding, as that term is defined in Section 1.4, or establishing or enforcing
a right to indemnification under this Agreement; PROVIDED, however, that
"Expenses" shall not include any judgments, fines, ERISA excise taxes or
penalties or amounts paid in settlement of a Proceeding, or prepaid retainers
for attorneys or other professionals engaged by or on behalf of the Indemnitee.

         1.3      Liability. For purposes of this Agreement, "Liability" or
"Liabilities," includes any judgment, fine, ERISA excise tax or penalty or any
amount paid, with the Company's written consent, in settlement of a Proceeding.

         1.4      Proceeding. For the purposes of this Agreement, "Proceeding"
means any threatened, pending or completed action, suit or other proceeding,
whether civil, criminal, administrative, investigative or any other type
whatsoever.

         2.       AGREEMENT TO SERVE. The Indemnitee agrees to serve and/or to
continue to serve as an Agent in the capacity the Indemnitee currently serves as
an Agent, as long as such service is mutually agreeable to Indemnitee and the
Company.

         3.       MAINTENANCE OF LIABILITY INSURANCE.

         3.1      Maintenance of Insurance. As long as the Indemnitee shall
continue to serve as an Agent and thereafter as long as the Indemnitee shall be
subject to any possible Proceeding by reason of the fact that the Indemnitee was
an Agent, the Company, subject to the provisions of Section 3.3 with respect to
the unavailability of satisfactory insurance coverage, shall promptly obtain
and/or maintain in full force and effect directors' and officers' liability
insurance ("D&O Insurance") in reasonable amounts from established and reputable
insurers. If D&O Insurance is obtained, the Company covenants that the
Indemnitee shall be named as an insured.



<PAGE>   3
                                      -3-

         3.2      Indemnitee Named as Insured. In all policies of D&O Insurance,
if any, the Indemnitee shall be named as an insured in such a manner as to
provide the Indemnitee the same rights and benefits as are accorded to the
Company's most favorably insured directors.

         3.3      Unavailability of Satisfactory Coverage. Notwithstanding the
foregoing, the Company shall have no obligation to obtain or maintain D&O
Insurance if the Company determines in good faith that such insurance is not
reasonably available, or that the premium costs for such insurance are
disproportionate to the amount of coverage provided or that the coverage
provided by such insurance is limited by exclusions so as to provide an
insufficient benefit. The failure of the Company to obtain D&O Insurance or the
decision by the Company not to obtain such coverage shall not have any
detrimental effect on the Indemnitee's rights hereunder.

         4.       MANDATORY INDEMNIFICATION.

         4.1      Third Party Actions. The Company shall indemnify the
Indemnitee when the Indemnitee is a party or is threatened to be made a party to
any Proceeding (other than an action by or in the right of the Company) by
reason of the fact that she is or was an Agent, or by reason of anything done or
not done by her in any such capacity, against any and all Expenses and
Liabilities of any type whatsoever actually and reasonably incurred by her in
connection with the investigation, defense, settlement or appeal of that
Proceeding if she acted in good faith and in a manner she reasonably believed to
be in or not opposed to the best interests of the Company, and, with respect to
any criminal action or proceeding, had no reasonable cause to believe her
conduct was unlawful. The termination of any Proceeding by judgment, order,
settlement, conviction or upon a plea of NOLO CONTENDERE or its equivalent shall
not create a presumption that the Indemnitee did not satisfy the foregoing
standard of conduct.

         4.2      Proceedings by or in the Right of the Company. The Company
shall indemnify the Indemnitee when the Indemnitee is a party or is threatened
to be made a party to any Proceeding by or in the right of the Company to
procure a judgment in its favor by reason of the fact that she is or was an
Agent, or by reason of anything done or not done by her in any such capacity,
against any amounts paid in settlement of any such proceeding and all expenses
actually and reasonably incurred by her in connection with the investigation,
defense, settlement or appeal of that Proceeding if she acted in good faith and
in a manner she reasonably believed to be in or not opposed to the best
interests of the Company; except that no indemnification under this subsection
shall be made in respect of any claim, issue or matter as to which such person
shall have been finally adjudged to be liable to the Company under the standards
of the Ohio General Corporation Law by a court of competent jurisdiction in the
performance of her duty to the Company unless and only to the extent that the
court in which such Proceeding was brought shall determine, upon application,
that, despite the adjudication of liability, but in view of all the


<PAGE>   4

                                      -4-


circumstances of the case, such person is fairly and reasonably entitled to
indemnity for such amounts which such court shall deem proper.

         4.3      Expenses or Liabilities Paid by D&O Insurance or the Trust.
Notwithstanding the foregoing, the Company shall not be obligated to indemnify
the Indemnitee for Expenses or Liabilities of any type whatsoever which have
been paid directly to, or for the benefit of, the Indemnitee by D&O Insurance or
out of any trust that may be established pursuant to Section 9 hereof. 


         5.       PARTIAL INDEMNIFICATION. If the Indemnitee is entitled under
any provision of this Agreement to indemnification by the Company for a part,
but not the total amount, of any Expenses or Liabilities of any type whatsoever
incurred by her in the investigation, defense, settlement or appeal of a
Proceeding, the Company shall indemnify the Indemnitee only for such amount to
which the Indemnitee is entitled as indemnification hereunder.

         6.       MANDATORY ADVANCEMENT OF EXPENSES. Subject to Sections 7 and
10 hereof, the Company shall advance all Expenses incurred by the Indemnitee in
connection with the investigation, defense, settlement or appeal of any
Proceeding to which the Indemnitee is a party or is threatened to be made a
party by reason of the fact that the Indemnitee is or was an Agent, or in
connection with any action brought by the Indemnitee to establish or enforce a
right to indemnification under this Agreement pursuant to Section 8 hereof, in
advance of the final disposition thereof. Indemnitee hereby undertakes: (x) to
repay all such amounts advanced if (but only if) it shall be proved by clear and
convincing evidence in a court of competent jurisdiction that his action or
failure to act involved an act or omission undertaken with deliberate intent to
cause injury to the Company or undertaken with reckless disregard for the best
interests of the Company; and (y) to cooperate reasonably with the Company in
connection with such Proceeding. The advances to be made hereunder shall be paid
by the Company to or for the benefit of the Indemnitee within twenty (20) days
following delivery of a written request therefor, accompanied by true and
complete copies of invoices therefor, by the Indemnitee to the Company.

         7.       NOTICE AND OTHER INDEMNIFICATION PROCEDURES.

         7.1      Notice to Company. Promptly after receipt by the Indemnitee of
notice of the commencement or the threatened commencement of any Proceeding, the
Indemnitee shall notify the Company of such commencement or threatened
commencement. The Indemnitee shall also provide the Company such information and
cooperation as the Company from time to time may reasonably request and as shall
reasonably be within the Indemnitee's power to provide. The Company shall have
no obligation to indemnify the Indemnitee under this Agreement if (but only if)
the Indemnitee's delay or failure to provide notice, information or cooperation
as required under this Section 7.1 results in a material impairment of the
Company's ability to defend the Proceeding or in the loss of coverage under any
applicable insurance policy.



<PAGE>   5
                                      -5-

         7.2      Notice to Insurance Carriers. If the Company has any
applicable insurance policy in effect at the time it receives notice pursuant to
Section 7.1 of the commencement or threatened commencement of a Proceeding, the
Company shall give prompt notice thereof to the insurer(s) in accordance with
the procedure set forth in the respective policies. The Company shall thereafter
take all necessary or desirable action to cause such insurers to pay, on behalf
of the Indemnitee, all amounts payable as a result of such Proceeding in
accordance with the terms of such policies.

         7.3      Choice of Counsel. In the event the Company shall be obligated
to advance the Expenses of any Proceeding against the Indemnitee, the Company
shall be entitled, in lieu thereof, to assume the defense of such proceeding
upon the delivery to the Indemnitee of written notice of the Company's election
to do so, which notice shall contain the name, address and phone number of
counsel engaged by the Company to handle such defense and confirmation that the
Company has undertaken to pay that counsel's reasonable fees and expenses
therefor. After delivery of such notice, the Company shall not be liable to the
Indemnitee under this Agreement for any fees or expenses of counsel for the
Indemnitee (other than the counsel engaged by the Company) subsequently incurred
by the Indemnitee with respect to the same Proceeding; PROVIDED, however, that
the fees and expenses of such counsel for the Indemnitee shall be at the expense
of the Company if (i) the employment of separate counsel by the Indemnitee has
been previously authorized by the Company, or (ii) the Indemnitee shall have
reasonably concluded, and either the Company shall have agreed, or independent
counsel (as defined herein) shall have determined, that there may be a conflict
of interest between the Company and the Indemnitee in the conduct of any such
defense; and FURTHER PROVIDED, however, that, the Indemnitee's counsel shall
have been approved by any carrier of an applicable insurance policy if required
under the terms of that policy. As used in this Section 7.3, "independent
counsel" shall mean counsel selected and compensated by the Company, and
reasonably approved by the Indemnitee, to determine whether a conflict of
interest may exist, which counsel shall not represent the Company, the
Indemnitee or any other party to the Proceeding for which indemnification is
sought. Independent counsel shall be selected promptly following notice from the
Indemnitee to the Company of the Indemnitee's belief that a conflict of interest
may exist. Nothing herein shall limit the right of the Indemnitee to employ
counsel at the Indemnitee's sole expense.

         8.       DETERMINATION OF RIGHT TO INDEMNIFICATION.

         8.1      Successful Defense. To the extent the Indemnitee has been
successful on the merits or otherwise in defense of any Proceeding referred to
in Sections 4.1 or 4.2 hereof or in the defense of any claim, issue or matter
described therein, the Company shall indemnify the Indemnitee against Expenses
actually and reasonably incurred by her in connection with the investigation,
defense or appeal of such Proceeding.



<PAGE>   6
                                      -6-

         8.2      Satisfaction of Standard of Conduct. In the event that Section
8.1 is inapplicable, (i) indemnification under Section 4.1 hereof shall be made
by the Company only upon a determination in accordance with this Section 8 that
the Indemnitee is entitled to indemnification hereunder, and (ii)
indemnification under Section 4.2 shall be made, if at all, in accordance with
the procedure set forth in Section 4.2. If the Indemnitee believes, upon the
disposition of any Proceeding described in Section 4.1 (whether by judgment,
settlement or otherwise), that the Indemnitee is entitled to indemnification
pursuant to this Agreement, the Indemnitee shall make written demand therefor
upon the Company. The Company shall indemnify the Indemnitee in accordance with
such demand unless, within forty-five (45) days after receipt of the
Indemnitee's demand, the Company notifies the Indemnitee that it has determined
that the Indemnitee has not met the applicable standard of conduct required to
entitle the Indemnitee to such indemnification (the "Notice of Denial"). The
Notice of Denial shall set forth, in reasonable detail, the basis for such
determination by the Company and the name of counsel selected by the Board
pursuant to Section 8.3.2 hereof.

         8.3      Forum for Determination of Satisfaction of Standard of
Conduct. Provided the Indemnitee notifies the Company of her choice of forum
within thirty (30) days after the receipt of a Notice of Denial, the Indemnitee
shall be entitled to select one of the following forums to determine whether she
met the applicable standard of conduct specified in Section 4.1 and is therefore
entitled to indemnification under this Agreement:

         8.3.1    Quorum of Disinterested Directors. A vote of a majority of a
         quorum (more than fifty percent (50%)) of the Board consisting of
         directors who are not parties to the Proceeding for which
         indemnification is being sought, based upon written submissions by the
         Company and the Indemnitee and, if the Indemnitee or directors so
         request, an oral presentation by the Indemnitee and by such other
         persons as such directors may request; PROVIDED, however, that the
         Indemnitee shall not have the right to be present during such
         directors' deliberations nor during presentations made to such
         directors by any person other than the Indemnitee;

         8.3.2    Counsel. Legal counsel selected by the Board (other than
         counsel to any party to the Proceeding for which indemnification is
         sought), and reasonably approved by the Indemnitee, which counsel shall
         make such determination in a written opinion based upon written
         submissions by the Company and the Indemnitee and responses to such
         questions as that counsel may have in such form as that counsel may
         request;

         8.3.3    Arbitration Panel. A majority vote of a panel of three
         arbitrators, one of whom is selected by the first two arbitrators so
         selected, which arbitration shall be conducted in accordance with the
         rules of the American Arbitration Association and such rules of
         procedure as may be established by the panel; or


<PAGE>   7

                                      -7-


         8.3.4    Court. The court in which the Proceeding is or was pending, in
         accordance with such rules of procedure as may be applicable to or
         established by that court.

         8.4      Submission to Forum. As soon as practicable, and in no event
later than thirty (30) days after the Indemnitee's written notice to the Company
of the Indemnitee's choice of forum pursuant to Section 8.3 above, the Company
shall, at its expense, submit to the selected forum its claim that the
Indemnitee is not entitled to indemnification. The Indemnitee shall be afforded
an adequate opportunity to defend against that claim. A presumption shall exist
that the Indemnitee is entitled to indemnification hereunder, and the Company
shall indemnify the Indemnitee unless the Company shall prove to the selected
forum, by clear and convincing evidence, that the Indemnitee has not met the
applicable standard of conduct required to entitle the Indemnitee to such
indemnification. The decision of the selected forum shall constitute a binding
and final adjudication between the Company and the Indemnitee as to the
Indemnitee's right to indemnification under Section 4.1 of this Agreement.

         8.5      Expenses of Determination. Notwithstanding any other provision
in this Agreement to the contrary, the Company shall indemnify the Indemnitee
against all Expenses incurred by the Indemnitee in connection with any hearing
or proceeding under this Section 8 involving the Indemnitee and against all
Expenses incurred by the Indemnitee in connection with any other Proceeding
between the Company and the Indemnitee involving the interpretation or
enforcement of the rights of the Indemnitee under this Agreement unless the
Company shall be deemed the prevailing party in any such proceeding.

         9.       INDEMNIFICATION TRUST AGREEMENT. In order to secure the
obligations of the Company to advance to the Indemnitee certain amounts under
Section 6 hereof, the Company may establish a trust fund naming the Indemnitee
as a beneficiary (in addition to all other directors, officers and other agents
with whom the Company enters into Indemnity Agreements, whether before, on, or
after the date hereof). The Indemnitee shall not seek any amount from the Trust,
if established, (i) unless entitled to an advance of Expenses pursuant to this
Agreement and (ii) unless and until the Indemnitee has made demand for payment
of Expenses pursuant to Section 6 hereof and, after twenty (20) days, the
Company has failed to advance such Expenses. The Indemnitee shall not be
entitled to receive a reimbursement or advance from the Trust, if established,
for a liability or other amount not expressly covered by Section 6 hereof.

         10.      EXCEPTIONS. Notwithstanding any other provision herein to the
contrary, the Company shall not be obligated pursuant to the terms of this
Agreement:

         10.1     Claims Initiated by the Indemnitee. To indemnify or advance
Expenses to the Indemnitee with respect to proceedings or claims initiated or
brought voluntarily by the Indemnitee and not by way of defense, except with
respect to proceedings brought to establish or enforce a right to
indemnification under this Agreement; or


<PAGE>   8

                                      -8-


         10.2 The Company Prevails in Action to Enforce or Interpret Agreement.
To indemnify the Indemnitee for any Expenses incurred by the Indemnitee with
respect to any Proceeding instituted by the Indemnitee to enforce or interpret
this Agreement, if the Company is deemed to be the prevailing party in such
proceeding; or

         10.3     Unauthorized Settlements. To indemnify the Indemnitee for any
amounts paid in settlement of a Proceeding unless the Company expressly consents
in writing to such settlement; or

         10.4     Failure to Settle Proceeding. To indemnify the Indemnitee for
Liabilities in excess of the total amount at which settlement reasonably could
have been made, or for any Expenses incurred by the Indemnitee following the
time such settlement reasonably could have been effected, if the Indemnitee
shall have unreasonably delayed, refused or failed to enter into a settlement of
any Proceeding (or investigation or appeal thereof) recommended in good-faith,
in writing, by the Company.

         11.      NO RESTRICTION OF OTHER INDEMNIFICATION RIGHTS. The Company
shall not adopt any amendment to its Articles of Incorporation or Regulations,
the effect of which would be to deny, diminish or encumber the Indemnitee's
rights to indemnity pursuant to the Articles of Incorporation, the Regulations,
the Ohio General Corporation Law or any other applicable law as applied to any
act or failure to act occurring in whole or in part prior to the date (the
"Effective Date") upon which the amendment shall apply only to acts or failures
to act occurring entirely after the Effective Date thereof, unless the
Indemnitee shall have voted in favor of the amendment as a director or holder of
record of the Company's common stock, as the case may be.

         12.      MERGER OR CONSOLIDATION. In the event that the Company shall
be a constituent corporation in a merger, consolidation or other reorganization,
the Company, if it shall not be the surviving, resulting or acquiring
corporation therein, shall require, as a condition thereto, that the surviving,
resulting, or acquiring corporation agree to indemnify the Indemnitee to the
full extent provided in this Agreement and to adopt and assume the Company's
obligations under this Agreement. Whether or not the Company is the surviving,
resulting or acquiring corporation in any such transaction, the Indemnitee shall
also stand in the same position under this Agreement as she would have with
respect to the Company if its separate existence had continued.

         13.      NON-EXCLUSIVITY. The provisions for indemnification and
advancement of expenses set forth in this Agreement shall not be deemed
exclusive of any other rights which the Indemnitee may have under any provision
of law, the Company's Articles of Incorporation or Regulations, the vote of the
Company's shareholders or disinterested directors, other agreements or
otherwise, whether as to actions in her official capacity or actions in another
capacity while





<PAGE>   9

                                      -9-


occupying her position as an Agent. The Indemnitee's rights hereunder shall
continue after the Indemnitee has ceased acting as an Agent and shall inure to
the benefit of the successors, heirs, executors, administrators, estates, legal
representatives and assigns of the Indemnitee.

         14.      INTERPRETATION OF AGREEMENT. It is understood that the parties
hereto intend this Agreement to be interpreted and enforced so as to provide
indemnification to the Indemnitee to the fullest extent now or hereafter
permitted by law; PROVIDED, however, that no change in any applicable law,
statute or rule which has the effect of narrowing the right of an Ohio
corporation to indemnify any Agent shall, unless otherwise required thereby,
affect this Agreement or the parties' rights or obligations hereunder.

         15.      HEADINGS. Descriptive headings in this Agreement are solely
for convenience and shall not control or affect the construction or
interpretation of any provision herein.

         16.      SEVERABILITY. If any provision or provisions of this Agreement
shall be held to be invalid, illegal or unenforceable for any reason whatsoever,
(i) the validity, legality and enforceability of the remaining provisions of the
Agreement (including without limitation, all portions of any paragraphs of this
Agreement containing any such provision held to be invalid, illegal or
unenforceable, that are not themselves invalid, illegal or unenforceable) shall
not in any way be affected or impaired thereby, and (ii) to the fullest extent
possible, the provisions of this Agreement (including, without limitation, all
portions of any paragraph of this Agreement containing any such provision held
to be invalid, illegal or unenforceable, that are not themselves invalid,
illegal or unenforceable) shall be construed so as to give effect to the intent
manifested by the provision held invalid, illegal or unenforceable and to give
effect to Section 13 hereof.

         17.      MODIFICATION AND WAIVER. No supplement, modification or
amendment of this Agreement shall be binding unless executed in writing by both
of the parties hereto. No waiver of any of the provisions of this Agreement
shall be deemed or shall constitute a waiver of any other provision hereof
(whether or not similar) nor shall such waiver constitute a continuing waiver.

         18.      SUCCESSORS AND ASSIGNS. The terms of this Agreement shall
bind, and shall inure to the benefit of, the successors, heirs, executors,
administrators, estates, legal representatives and assigns of the parties
hereto; PROVIDED, however, that the Indemnitee may not delegate her duties
hereunder; and PROVIDED FURTHER, that no assignment shall obligate the Company
to provide any indemnification with respect to the actions or failures to act of
any person other than the Indemnitee specifically named herein.

         19.      NOTICES. All notices, requests, demands, waivers and other
communications required or permitted to be given under this Agreement shall be
in writing and shall be deemed to have been given when delivered personally by
overnight carrier or by telecopy with telephonic


<PAGE>   10

confirmation of receipt or by two (2) business days after being deposited in the
U.S. mail, certified or registered, return receipt requested with postage
prepaid, and addressed to the party to whom such notice, request, demand, waiver
or other communication is to be given as follows, or at such other address as
either party shall designate by notice to the other party pursuant to this
section:

         The Company:               Kendle International Inc.
                                    700 Carew Tower
                                    Cincinnati, Ohio 45202
                                    Attention: Candace Kendle
                                               Chairman of the Board
                                               and Chief Executive Officer

         with a required copy to:   Paul F. Ritter, Esq.
                                    700 Carew Tower
                                    Cincinnati, Ohio 45202

         Indemnitee:                Mary Beth Price
                                    5607 Brookstone Drive
                                    Cincinnati, Ohio 45230

         20.      GOVERNING LAW. This Agreement, and the rights and duties of
the parties hereto under this Agreement, shall be governed exclusively by and
construed in accordance with the laws of the State of Ohio, as applied to
contracts between Ohio residents entered into and to be performed entirely
within Ohio.

         21.      CONSENT TO JURISDICTION. Except as expressly provided in
Section 8 hereof, the Company and the Indemnitee each hereby irrevocably consent
to the jurisdiction of the courts of the State of Ohio for all purposes in
connection with any action or proceeding which arises out of or relates to this
Agreement and agree that any action instituted under this Agreement shall be
brought only in the state courts of the State of Ohio.

         22.      COUNTERPARTS. This Agreement may be executed in two (2) or
more counterparts, and by each party on separate counterparts, each of which
counterparts shall be deemed an original, but all of which counterparts taken
together shall be one and the same document.

         23.      PUBLIC POLICY DETERMINATIONS. The Company and the Indemnitee
acknowledge that, in certain circumstances, federal law or applicable public
policy may prohibit the Company from indemnifying the Indemnitee under this
Agreement or otherwise. The Indemnitee understands and acknowledges that the
Company has undertaken, and may in the future be 

<PAGE>   11

                                      -11-

required to undertake, to submit the question of the Company's right under
public policy to indemnify the Indemnitee to a court of appropriate jurisdiction
under certain circumstances, unless, in the opinion of counsel, such matter has
been settled by controlling precedent, and that such determination shall be
binding on the Company and the Indemnitee.

(remainder of page intentionally blank)


<PAGE>   12

                                      -12-

         The parties hereto have entered into this Indemnity Agreement effective
as of the date first above written.


                                        KENDLE INTERNATIONAL INC.


                                        By: /s/ Candace Kendle
                                            -----------------------------------
                                            Candace Kendle,
                                            Chairman of the Board
                                            and Chief Executive Officer



                                        INDEMNITEE:

                                        /s/ Mary Beth Price
                                        ----------------------------------------
                                        Mary Beth Price






<PAGE>   1

                                                                  EXHIBIT 10.20e


                            KENDLE INTERNATIONAL INC.
                        1998 EMPLOYEE STOCK PURCHASE PLAN


         1.       PURPOSE.

         The purpose of this Plan is to provide employees of Kendle and its
subsidiaries added incentive to their employment and to encourage their
increased efforts to promote the best interests of Kendle. The Plan seeks to
accomplish this purpose by permitting eligible employees to purchase Common
Shares of Kendle at below-market prices. For purposes of the Plan, a subsidiary
of the corporation of which Kendle is the common parent, is as defined by the
Internal Revenue Code of 1986 in Section 424(f). As used in this Plan, the term
"Kendle" means Kendle International Inc. and all such subsidiaries. This Plan is
intended to qualify as an "employee stock purchase plan" under Section 423 of
the Internal Revenue Code and all provisions of this Plan are to be construed so
as to meet that tax objective.

         2.       ELIGIBILITY.

         This Plan is available to each Eligible Employee of Kendle who meets
the following tests on the first day of a Purchase Period as defined in Section
3. An Eligible Employee is one (a) who has been continuously employed by Kendle
for at least one month; (b) whose customary employment by Kendle is at least 24
hours per week; and (c) whose customary employment by Kendle is more than five
months in any calendar year.

         An Eligible Employee may not purchase Common Shares hereunder if,
immediately thereafter such employee would own 5% or more of the total combined
voting power or value of all classes of stock of Kendle or any subsidiary
including attributable stock under Section 424(d) of the Internal Revenue Code,
or if, for a given calendar year, such employee's aggregate rights to purchase
stock under all employee stock purchase plans of Kendle would exceed $25,000 of
fair market value of such stock for such calendar year, all determined in the
manner provided by Section 423(b)(8) of the Internal Revenue Code.

         3.       EFFECTIVE DATE; TERM; PURCHASE PERIODS.

         This Plan shall become effective on June 30, 1998 or such later date as
may be specified by the Board of Directors. This Plan shall cease to be
effective unless, within 12 months after the date of its adoption by the Board,
it has been approved at a meeting of the shareholders of Kendle.

         This Plan shall remain in effect until all Common Shares issuable under
the Plan have been issued or June 30, 2003, whichever occurs first.

         A "Purchase Period" shall consist of the twelve month period beginning
on each July 1, commencing on or after the effective date and prior to
termination of the Plan.



<PAGE>   2

                                      -2-




         4.       ADMINISTRATION OF THE PLAN.

         The Plan shall be administered by a Committee designated by the Board
consisting of two or more members of the Board, each of whom is a Non-Employee
Director within the meaning of Rule 16b-3(b) promulgated under the Securities
Exchange Act of 1934.

         In addition to the power to amend or terminate the Plan pursuant to
Section 9, the Committee shall have full power and authority to: (i) interpret
and administer the Plan and any instrument or agreement entered into under the
Plan; (ii) establish such rules and regulations and appoint such agents as it
shall deem appropriate for the proper administration of the Plan; and (iii) make
any other determination and take any other action that the Committee deems
necessary or desirable for administration of the Plan. Decisions of the
Committee shall be final, conclusive and binding upon all persons, including
Kendle, any participant and any other employee of Kendle. A majority of the
members of the Committee may determine its actions and fix the time and place of
its meetings.

         The Plan shall be administered so as to ensure all participants have
the same rights and privileges as are provided by Section 423(b)(5) of the
Internal Revenue Code.

         5.       BASIS OF PARTICIPATION.

                  5.1      PAYROLL DEDUCTION. Each Eligible Employee shall be
entitled to enroll in the Plan as of the first day of the Purchase Period which
begins after such employee has become an Eligible Employee.

         To enroll in the Plan, an Eligible Employee shall execute and deliver a
payroll deduction authorization to Kendle or its designated agent. The
authorization shall become effective on the first day of the Purchase Period
following the execution and delivery of such authorization. Each authorization
shall direct that payroll deductions be made by Kendle for each payroll period
during which the employee is a participant in the Plan. The amount of each
payroll deduction for each such payroll period shall be a whole percentage
amount or a whole dollar amount, as determined by the Committee, in either case
not less than One Percent nor more than Ten Percent, or such greater or lesser
percentages as may be determined by the Committee, of the participant's current
regular wage or salary (before withholding or other deductions) paid to him/her
by Kendle.

         Payroll deductions (and any other amount paid under the Plan) shall be
made for each participant in accordance with his/her authorization until
participation in the Plan terminates, the authorization is revised or the Plan
terminates, all as hereinafter provided.

         A participant may not change the amount of payroll deduction during any
Purchase Period. Any requested changes on the amount of payroll deductions will
be effective beginning 


<PAGE>   3
                                      -3-

on the first day of the next Purchase Period, subject to a participant's right
to terminate participation in the Plan at any time as provided in Section 8.

         Payroll deductions shall be credited to an account established for each
participant. At the end of each Purchase Period, the amount in each
participant's account will be applied to purchase Kendle Common Shares for such
Purchase Period. No interest shall accrue at any time for any amount credited to
a participant's account.

                  5.2      OTHER METHODS OF PARTICIPATION. The Committee may
establish additional procedures whereby Eligible Employees may participate in
the Plan by means other than payroll deduction, such as delivery of funds by
participants in a lump sum or automatic charges to participants' bank accounts.
Such other methods of participating shall be subject to such rules and
conditions as the Committee may establish. The Committee may at any time amend,
suspend or terminate any participation procedures established pursuant to this
paragraph without prior notice to any participant to Eligible Employee.

         6.       PURCHASE PRICE.

         The purchase price for Common Shares purchased under the Plan for any
Purchase Period shall be the lesser of (i) 85% of the fair market value of the
Common Stock on the first day of such Purchase Period or (ii) 85% of the fair
market value of the Common Shares on the last day of such Purchase Period. "Fair
market value" means the average of the highest and lowest quoted selling prices
for the Common Share as reported on the National Market System of The Nasdaq
Stock Market or such other consolidated transaction reporting system on which
the shares are primarily traded. If the shares are not traded on such date, then
the next preceding day on which the shares were traded, all as reported by such
source as the Committee may select. If the shares are not traded on a national
securities exchange or other market system, fair market value shall be set under
procedures established by the Committee.

         7.       ISSUANCE OF SHARES.

         Common Shares purchased by each participant shall be considered to be
issued and outstanding to the participant's credit as of the close of business
on the last day of each Purchase Period. A participant may any time withdraw
certificates for all or a portion of the Common Shares credited to his or her
account by giving written notice to Kendle, provided, however, that (a) no such
request may be made more frequently than once per Purchase Period, (b) such
request shall be for at least 25 Common Shares and (c) no participant shall be
entitled to receive a certificate for any fractional share. Kendle will pay any
stamp taxes imposed in connection with the issuance of any certificate under the
Plan.

         After the close of each Purchase Period, a report will be sent to each
participant stating entries made to the account, the number of Common Shares
purchased and the applicable purchase price.






<PAGE>   4
                                      -4-


         8.       TERMINATION OF PARTICIPATION.

         A participant may at any time terminate participation in the Plan,
provided such termination is received by Kendle in writing prior to the last
business day of the Purchase Period for which such termination is to be
effective. Upon any such termination, Kendle shall promptly deliver to such
participant certificates for the number of full Common Shares held in the
account and cash equal to any remaining balances and in lieu of any fractional
shares. Such cash equivalent shall be determined by multiplying the fractional
share by the fair market value of a Common Share on the last day of the Purchase
Period immediately preceding such termination, determined as provided in Section
6.

         If the participant dies, terminates employment with Kendle for any
reason, or otherwise ceases to be an Eligible Employee, participation in the
Plan shall immediately terminate. In such event, certificates for the number of
full Common Shares held in the account, cash equal to any remaining balances and
the cash equivalent of any fractional share so held, determined as provided in
Section 6, shall be delivered promptly to such participant.

         9.       TERMINATION OR AMENDMENT OF THE PLAN.

         Kendle may terminate the Plan at any time. Notice of termination shall
be given to all participants, but any failure to give such notice shall not
impair the effectiveness of the termination.

         The Plan will terminate in any event when the maximum number of Common
Shares to be sold under the Plan has been purchased. Such termination shall not
impair any rights which under the Plan shall have vested on or prior to the date
of such termination. If at any time the number of shares remaining available for
purchase under the Plan are not sufficient to satisfy all then-outstanding
purchase rights, the Board may determine an equitable basis of allocating
available shares among all participants.

         The Board may amend the Plan from time to time; provided, however, no
such amendment shall (a) materially adversely affect any purchase rights
outstanding under the Plan during the Purchase Period in which such amendment is
to be effected, (b) increase the maximum number of Common Shares which may be
purchased under the Plan, (c) decrease the purchase price of the Common Shares
for any purchase period below the lesser of 85% of fair market value on either
of the first or the last day of such Purchase Period or (d) adversely affect the
qualification of the Plan under Section 423 of the Internal Revenue Code.

         Upon termination of the Plan, certificates for the number of full
Common Shares held in the account, cash equal to any remaining balances and the
cash equivalent of any fractional share so held, determined as provided in
Section 6, shall be delivered promptly to such participant.


<PAGE>   5

                                      -5-


         10.      NON-TRANSFERABILITY.

         No right or interest in this Plan shall be assignable or transferable,
or subject to any lien, directly or indirectly, by operation of law, or
otherwise, including execution, levy, garnishment, attachment, pledge or
bankruptcy. Any attempted assignment, transfer, pledge or other disposition of
any rights under this Plan shall be null and void and shall automatically
terminate all rights of a participant under the Plan.

         11.      SHAREHOLDER'S RIGHTS.

         No Eligible Employee or participant shall by reason of this Plan have
any rights of a shareholder of Kendle until and to the extent such person
acquires Common Shares as herein provided.

         12.      MAXIMUM NUMBER AND SOURCE OF SHARES; ADJUSTMENTS.

         The maximum number of Common Shares which may be purchased under this
Plan is Five Hundred Thousand (500,000) shares. Common Shares sold hereunder may
be treasury shares, authorized and unissued shares, or a combination thereof.
The Committee may also purchase Common Shares on behalf of the participants
through market transactions.

         If Kendle shall, at any time change its issued Common Shares into a
different number through stock dividend, stock split, combination or otherwise,
the number of Common Shares specified in this Plan shall be proportionately
adjusted.

         13.      MISCELLANEOUS.

                  13.1     Any authorization, election, notice or document under
this Plan from an Eligible Employee or participant shall be delivered to Kendle
and shall be effective when delivered.

                  13.2     This Plan, and Kendle's obligation to sell and
deliver Common Shares hereunder, shall be subject to all applicable federal,
state and foreign laws, rules and regulations, and to such approval by any
regulatory or governmental agency as may, in the opinion of counsel for Kendle,
be required.





<PAGE>   1
                                                                Exhibit 10.20(f)

                            KENDLE INTERNATIONAL INC.

                        1997 DIRECTORS' COMPENSATION PLAN

         This Directors' Compensation Plan has been adopted by the Board of
Directors of Kendle International Inc. in order to align further the interests
of the Company's non-employee Directors with the interests of shareholders by
providing that their compensation be paid through the issuance of Common Shares
of the Company.

1.       COMPENSATION OF NON-EMPLOYEE DIRECTORS.

         All Directors who are not employees of the Company shall be paid the
following fees as provided in Section 2 below:

         a.       a retainer of $1,000 for each meeting of the Board of
                  Directors attended;

         b.       a retainer of $500 for each committee meeting attended; and

         c.       such fees shall be reduced to 50% of the amount stated above
                  if the meetings are by telephone.

2.       PAYMENT TERMS.

         The meeting fees set forth in Section 1 above shall be paid by the
Company quarterly, in arrears, as soon as practicable following the end of each
quarter in the form of Company Common Shares.

         The number of Common Shares to be issued shall be determined by
dividing the dollar amount of the fee by the average of the per share Fair
Market Value of the Common Shares, as defined in Section 3, for the ten trading
days prior to the end of each quarter. The resulting number shall then be
rounded up to the nearest share.

3.       FAIR MARKET VALUE OF COMPANY COMMON SHARES.

         "Fair Market Value" means the last sale price reported on any stock
exchange or over-the-counter trading system on which the Common Shares are
trading on the last trading day prior to a specified date or, if no last sales
price is reported, the average of the closing bid and asked prices for a Common
Share on a specified date. If no sale has been made on any date, prices on the
last preceding day on which any such sale shall have been made will be used in
determining Fair Market Value under either method prescribed in the previous
sentence.

4.       RESTRICTIVE LEGEND; HOLDING PERIOD FOR COMMON SHARES

         In order to comply with Federal securities laws, all certificates for
Common Shares issued 


<PAGE>   2


pursuant to this Plan shall bear the following restrictive legend which will
prevent the recipient from disposing of such shares for six months from the date
of issuance:

         THE COMMON SHARES REPRESENTED BY THIS CERTIFICATE MAY NOT BE OFFERED,
         SOLD, TRANSFERRED, PLEDGED, HYPOTHECATED OR OTHERWISE ASSIGNED UNTIL
         THE EXPIRATION OF THE SIX MONTH PERIOD BEGINNING ON THE DATE OF
         ORIGINAL ISSUANCE BY KENDLE INTERNATIONAL INC. AS PROVIDED BY THE
         COMPANY'S 1997 DIRECTORS' COMPENSATION PLAN, A COPY OF WHICH WILL BE
         MAILED TO THE HOLDER WITHOUT CHARGE WITHIN FIVE DAYS AFTER RECEIPT OF
         WRITTEN REQUEST THEREFOR.

         When the legend requirement imposed by this Section 4 shall terminate,
the holder of Common Shares for which such legend requirements have terminated
may request that the Company issue replacement certificates representing such
shares without such legend.

5.       NO RIGHT TO CONTINUANCE AS A DIRECTOR.

         Neither the action of the Company in establishing this Plan, nor the
issuance of Common Shares shall be deemed to create any obligation on the part
of the Board of Directors to nominate any non-employee Director for reelection
by the Company's shareholders or to be evidence of any agreement or
understanding, express or implied, that the non-employee Director has a right to
continue as a Director for any period of time or at any particular rate of
compensation.

6.       SHARES SUBJECT TO THE PLAN.

         Common Shares are authorized for issuance under this Plan in accordance
with the provisions hereof. The Company shall at all times during the term of
the Plan retain as authorized and unissued Common Shares at least the number of
shares from time to time required under the provisions of the Plan, or otherwise
assure itself of its ability to perform its obligations hereunder.


                                       2
<PAGE>   3


7.       AMENDMENT.

         The amount, pricing and timing of Common Share issuances pursuant to
this Plan shall not be amended more than once every six months, other than to
comport with changes in the Internal Revenue Code of 1986, as amended, the
Employee Retirement Income Security Act of 1984, as amended, or the rules
thereunder.

8.       EFFECTIVE DATE AND EXPIRATION OF PLAN.

         The Plan is effective as of August 15, 1997, subject to approval by a
majority of the votes cast at the next Annual Meeting of Shareholders of the
Company, by the holders of Common Shares entitled to vote thereon. Unless
earlier terminated by the Board pursuant to Section 10, this Plan shall
terminate on the tenth anniversary of the Effective Date. No Common Shares shall
be issued pursuant to this Plan after its termination.

9.       PAYMENT IN EVENT OF DEATH.

         Upon the death of a non-employee Director, any portion of the
compensation pursuant to this Plan then unpaid shall be paid to the
beneficiaries named in the most recent beneficiary designation filed with the
Secretary of the Company. In the absence of such a designation, such
compensation shall be paid to, or as directed by, the decedent's personal
representative, in one or more installments as the non-employee Director may
have elected in writing.

10.      AMENDMENT, SUSPENSION AND TERMINATION OF PLAN.

         The Board of Directors may suspend or terminate this Plan or any
portion of it at any time, and, subject to Section 7, may amend it from time to
time in such respects as the Board of Directors may deem advisable so that any
awards hereunder shall conform to any change in applicable laws or regulations
or in any other respect the Board of Directors may deem to be in the best
interests of the Company; provided, however, that no such amendment shall,
without shareholder approval, increase the number of Common Shares which may be
issued under the Plan, materially increase the benefits accruing to Directors
under the Plan, materially modify the requirements as to eligibility for
participating in the Plan, or extend the termination date of the Plan.





                                       3


<PAGE>   1
                                                                   EXHIBIT 10.21


                                                                  EXECUTION COPY


                                            FIRST AMENDMENT dated as of November
                                    25, 1998 (this "FIRST AMENDMENT") to the
                                    Amended and Restated Credit Agreement dated
                                    as of February 26, 1998 (as amended,
                                    modified or otherwise supplemented through
                                    the date hereof, the "CREDIT AGREEMENT"),
                                    among Kendle International Inc. (the
                                    "BORROWER"), the Lenders (as defined in the
                                    Credit Agreement) and NationsBank, N.A., as
                                    Agent for the Lenders (in such capacity, the
                                    "AGENT"), and as Issuing Lender.

         Capitalized terms used and not otherwise defined herein shall have the
meanings assigned to such terms in the Credit Agreement (the Credit Agreement,
as amended by, and together with, this First Amendment, and as hereinafter
amended, modified, supplemented, extended or restated from time to time, being
called the "AMENDED CREDIT AGREEMENT").

         The Borrower has requested the Lenders to, among other things, amend
certain covenants contained in the Credit Agreement.

         The parties hereto have agreed, subject to the terms and conditions
hereof, to amend the Credit Agreement as provided herein.

         Accordingly, the parties hereto hereby agree as follows:

         SECTION 1. AMENDMENTS TO THE CREDIT AGREEMENT. Subject to satisfaction
of the conditions precedent set forth in Section 3 of this First Amendment, the
Credit Agreement is hereby amended as follows:

                  (a)      The definition of "Change of Control" contained in
         Section 1.1 of the Credit Agreement is hereby deleted therefrom in its
         entirety and the following definition is substituted in lieu thereof:

                  ""CHANGE OF CONTROL" shall mean any of the following events:
                  (a) any person or "group" (within the meaning of Rule 13d-5
                  under the Exchange Act), together with its Affiliates, other
                  than Candace Kendle Bryan and Christopher C. Bergen, shall
                  beneficially own, directly or indirectly, the lesser of (i) an
                  amount of Capital Stock of the Borrower entitled to twenty
                  percent (20%) or more of the Total Voting Power of the
                  Borrower or (ii) an amount of Capital Stock of the Borrower
                  entitled to a percentage of the Total Voting Power of the
                  Borrower in excess of the aggregate of such Capital Stock
                  owned, directly or indirectly, by Candace Kendle Bryan and
                  Christopher C. Bergen; (b) Candace Kendle Bryan and
                  Christopher C. Bergen together cease to own shares of Capital
                  Stock of the Borrower representing at least ten percent (10%)
                  of the Total Voting Power of the Borrower; or (c) during any
                  period of two consecutive years, individuals who at the
                  beginning of such period constituted the Board of Directors of
                  the Borrower (together with any new directors whose election
                  by such Board of Directors or whose nomination for election by
                  the shareholders of the Borrower was approved by a vote of
                  sixty-six and 2/3 percent


<PAGE>   2

                  (66-2/3%) of the directors of the Borrower then still in
                  office who were either directors at the beginning of such
                  period or whose election or nomination for election was
                  previously so approved) cease for any reason to constitute a
                  majority of the Board of Directors of the Borrower then in
                  office."

                  (b)      The definition of "Collateral Documents" contained in
         Section 1.1 of the Credit Agreement is hereby deleted therefrom in its
         entirety and the following definition is hereby substituted in lieu
         thereof:

                  ""COLLATERAL DOCUMENTS" shall mean the Pledge Agreement, the
                  Permitted Tax Distribution Agreements, such other documents
                  executed and delivered in connection with the attachment and
                  perfection of the Agent's security interests and liens arising
                  thereunder and all documents and instruments delivered under
                  and pursuant to Section 6.11."

                  (c)      The definition of "Fixed Charge Coverage Ratio"
         contained in Section 1.1 of the Credit Agreement is hereby deleted
         therefrom in its entirety and the following definition is hereby
         substituted in lieu thereof:

                  ""FIXED CHARGE COVERAGE RATIO" shall mean, as of any reporting
                  day, the ratio of (a) Consolidated EBITDA for the period of
                  four consecutive fiscal quarters of the Borrower ending on, or
                  most recently preceding, such day, PLUS Consolidated Rent
                  Expense for such period MINUS Consolidated Capital
                  Expenditures for such period, to (b) the sum of (i)
                  Consolidated Interest Expense for such period, PLUS (ii)
                  Consolidated Rent Expense for such period, PLUS (iii)
                  Consolidated Scheduled Funded Debt Payments for such period,
                  PLUS (iv) Consolidated Cash Dividends for such period."

                  (d)      The definition of "Life Insurance Assignment"
         contained in Section 1.1 of the Credit Agreement is hereby deleted
         therefrom in its entirety.

                  (e)      The definition of "Life Insurance Policy" contained
         in Section 1.1 of the Credit Agreement is hereby deleted in its
         entirety.

                  (f)      The definition of "Permitted Acquisition" contained
         in Section 1.1 of the Credit Agreement is hereby deleted therefrom in
         its entirety and the following definition is hereby substituted in lieu
         thereof:

                  ""PERMITTED ACQUISITION" shall mean an acquisition by the
                  Borrower or any Wholly Owned Domestic Subsidiary of the
                  Borrower of the Capital Stock or all or substantially all of
                  the Property of another Person (including by merger or
                  consolidation or by incorporation of a new Subsidiary) for up
                  to the fair market value of the Capital Stock or Property
                  acquired, PROVIDED, THAT, (a) the Capital Stock or Property
                  acquired in such acquisition relates directly to or is
                  strategically related to the business of the Borrower or any
                  of its Subsidiaries as existing on the Effective Date, (b) any
                  Indebtedness issued, incurred (other than under this
                  Agreement) or




                                      -2-
<PAGE>   3



                  assumed by the Borrower and its Subsidiaries on a consolidated
                  basis from such acquisition (as permitted hereunder) shall not
                  in the aggregate exceed $5,000,000, (c) the Agent shall have
                  received all items in respect of the Capital Stock or Property
                  acquired in such acquisition (and/or the seller thereof)
                  required to be delivered by the terms of Section 6.11, (d) in
                  the case of an acquisition of the Capital Stock of another
                  Person, (i) the board of directors (or other comparable
                  governing body) of such other Person shall have duly approved
                  such acquisition and (ii) the Capital Stock acquired shall
                  constitute 100% of the Total Voting Power and ownership
                  interest of the issuer thereof, (e) no Default or Event of
                  Default shall have occurred and be continuing immediately
                  before or immediately after giving effect to such acquisition
                  and the Borrower shall have delivered to the Agent a Pro Forma
                  Compliance Certificate demonstrating that, upon giving effect
                  to such acquisition on a Pro Forma Basis, the Borrower shall
                  be in compliance with all of the financial covenants set forth
                  in Section 7.18 as of the last day of the most recent period
                  of four consecutive fiscal quarters of the Borrower which
                  precedes or ends on the date of such acquisition and with
                  respect to which the Agent has received the Required Financial
                  Information, (f) the representations and warranties made by
                  the Credit Parties in each Credit Document shall be true and
                  correct in all material respects as of the date of such
                  acquisition (as if made on such date after giving effect
                  thereto) except to the extent such representations and
                  warranties expressly relate to an earlier date (in which case
                  such representations and warranties shall be true and correct
                  in all material respects at and as of such earlier date), (g)
                  after giving effect to such acquisition, the Revolving
                  Committed Amount shall be at least $5,000,000 greater than the
                  sum of all Revolving Loans outstanding PLUS all LOC
                  Obligations outstanding, PLUS all Competitive Bid Loans
                  outstanding, (h) the aggregate consideration (including cash,
                  assumption of indebtedness and non-cash consideration) for any
                  single acquisition (or series of related acquisitions) shall
                  not exceed $30,000,000 and (i) the aggregate cash
                  consideration for any single acquisition (or series of related
                  acquisitions) shall not exceed $10,000,000 and the aggregate
                  cash consideration for all such acquisitions occurring during
                  any calendar year of the Borrower during the term hereof shall
                  not exceed $30,000,000."



                                      -3-
<PAGE>   4


                  (g)      The definition of "Permitted Investments" contained
         in Section 1.1 of the Credit Agreement is hereby deleted therefrom in
         its entirety and the following definition is hereby substituted in lieu
         thereof:

                  ""PERMITTED INVESTMENTS" shall mean Investments which consist
                  of (a) cash or Cash Equivalents; (b) trade accounts receivable
                  (and related notes and instruments) arising in the ordinary
                  course of business in accordance with customary trade terms;
                  (c) Investments existing as of the Effective Date and set
                  forth in SCHEDULE 1.1A; (d) Guaranty Obligations permitted by
                  Section 7.1; (e) advances or loans to directors, officers,
                  employees, agents, customers or suppliers that do not exceed
                  $250,000 in the aggregate at any one time outstanding for all
                  of the Borrower and its Subsidiaries; (f) Investments by the
                  Borrower or any Wholly Owned Subsidiary in Subsidiaries of the
                  Borrower or by any Subsidiary in the Borrower evidenced by
                  Intercompany Notes pledged to the Agent for the benefit of the
                  Secured Parties; PROVIDED, THAT, (i) the aggregate principal
                  amount of such Intercompany Notes issued by Foreign
                  Subsidiaries of the Borrower to the Borrower or to any
                  Domestic Subsidiary of the Borrower and outstanding at any
                  time shall not exceed $5,000,000 in the aggregate, (ii) no
                  Investments shall be made in the Capital Stock of any Foreign
                  Subsidiary except as a Permitted Acquisition; and (iii)
                  Investments in a Wholly Owned Subsidiary are permitted only so
                  long as such person remains a Wholly Owned Subsidiary; (g)
                  Investments by the Borrower or any Wholly Owned Subsidiary in
                  any Person; PROVIDED, THAT, the aggregate consideration for
                  all such Investments shall not exceed $8,000,000; or (h)
                  Permitted Acquisitions."

                  (h)      Section 5.25(a) of the Credit Agreement is hereby
         deleted therefrom in its entirety and the following definition is
         hereby substituted in lieu thereof:

                           "5.25 SECURITY DOCUMENTS. (a) The Pledge Agreement is
                  effective to create in favor of the Agent, for the ratable
                  benefit of the Secured Parties, a legal, valid and enforceable
                  first priority security interest in 100% of the issued and
                  outstanding Capital Stock of all Subsidiaries (PROVIDED that
                  no shares of Capital Stock of any issuer incorporated in a
                  jurisdiction outside of the United States of America shall be
                  pledged to the extent that the aggregate amount of shares of
                  Capital Stock of such issuer pledged under the Pledge
                  Agreement would exceed 65% of the Capital Stock of such issuer
                  to the extent, and for so long as, the pledge of any greater
                  percentage would have adverse tax consequences for the
                  pledging party), and, when the Pledged Securities (as defined
                  in the Pledge Agreement) are delivered to the Agent, the
                  Pledge Agreement shall constitute a fully perfected Lien on,
                  and security interest in, all right, title and interest of the
                  grantors thereunder in such of the Collateral in which a
                  security interest can be perfected under Article 8 or 9 of the
                  Uniform Commercial Code prior and superior in right to any
                  other Person, other than with respect to Permitted Liens."

                  (i)      Section 6.12 of the Credit Agreement is hereby
         deleted therefrom in its entirety.




                                      -4-
<PAGE>   5


                  (j)      Section 7.7 of the Credit Agreement is hereby deleted
         therefrom in its entirety and the following definition is hereby
         substituted in lieu thereof:

                           "7.7 RESTRICTED PAYMENTS. None of the Credit Parties
                  will, directly or indirectly, declare, order, make or set
                  apart any sum for or pay any Restricted Payment, except (a)
                  dividends payable solely in common stock of such Person, (b)
                  dividends or other distributions payable to (i) the Borrower
                  or any Wholly Owned Domestic Subsidiary of the Borrower and
                  (ii) the shareholders of the common stock of the Borrower, (c)
                  repurchases of common stock of the Borrower from any employee
                  of the Credit Parties upon the termination of employment of
                  such employee; PROVIDED, THAT, the aggregate amount paid in
                  all such repurchases shall not exceed $750,000 in any fiscal
                  year of the Borrower during the term of this Amended
                  Agreement, (d) repurchases of common stock of the Borrower in
                  addition to such repurchases permitted pursuant to clause (c)
                  of this Section 7.7; PROVIDED, THAT the aggregate amount paid
                  in all such repurchases permitted pursuant to this clause (d)
                  shall not exceed $5,000,000; PROVIDED, THAT, in each case as
                  set forth in clauses (a) through (d) above, no Default or
                  Event of Default has occurred and is continuing at such time
                  or would exist after giving effect to such payment on a pro
                  forma basis as if it had been made on the first day of the
                  most recently completed period of four consecutive fiscal
                  quarters of the Borrower."

         SECTION 2. REPRESENTATIONS AND WARRANTIES. The Borrower hereby
represents and warrants to the Agent and the Lenders, as follows:

                  (a)      The Borrower is in compliance with all the terms and
         conditions of the Credit Agreement on its part to be observed or
         performed. There exists no Default or Event of Default.

                  (b)      The execution, delivery and performance by the
         Borrower of this First Amendment have been duly authorized by the
         Borrower.

                  (c)      This First Amendment constitutes the legal, valid and
         binding obligation of the Borrower, enforceable against it in
         accordance with its terms.

                  (d)      The execution, delivery and performance by the
         Borrower of this First Amendment (i) do not conflict with or violate
         (A) any provision of law, statute, rule or regulation, or of the
         constitutive documents of the Borrower, (B) any order of any
         Governmental Authority or (C) any provision of any indenture, agreement
         or other instrument to which the Borrower is a party or by which it or
         any of its property may be bound and (ii) do not require any consents
         under, result in a breach of or constitute (with notice or lapse of
         time or both) a default under any such indenture, agreement or
         instrument.

         SECTION 3. EFFECTIVENESS. This First Amendment shall become effective
only upon satisfaction of the following conditions precedent (the first date
upon which each such condition has been satisfied being herein called the
"AMENDMENT EFFECTIVE DATE").


                                      -5-

<PAGE>   6


                  (a)      The Agent shall have received duly executed
         counterparts of this First Amendment which, when taken together, bear
         the authorized signatures of the Borrower and the Required Lenders.

                  (b)      The Agent shall be satisfied that the representations
         and warranties set forth in Section 2 are true and correct on and as of
         the Amendment Effective Date.

                  (c)      There shall not be any action pending or any
         judgment, order or decree in effect which, in the judgment of the Agent
         or the Lenders, is likely to restrain, prevent or impose materially
         adverse conditions upon performance by the Borrower of its obligations
         under the Amended Credit Agreement.

                  (d)      The Agent shall have received such other documents,
         legal opinions, instruments and certificates relating to this First
         Amendment as they shall reasonably request and such other documents,
         legal opinions, instruments and certificates shall be satisfactory in
         form and substance to the Agent and the Lenders. All corporate and
         other proceedings taken or to be taken in connection with this First
         Amendment and all documents incidental thereto, whether or not referred
         to herein, shall be satisfactory in form and substance to the Agent and
         the Lenders.

         SECTION 4. APPLICABLE LAW. THIS FIRST AMENDMENT SHALL BE GOVERNED BY,
AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NORTH CAROLINA.

         SECTION 5. EXPENSES. The Borrower shall pay all fees and expenses of
counsel to the Agent outstanding as of the date hereof and all reasonable
out-of-pocket expenses incurred by the Agent and the Lenders in connection with
the preparation, negotiation, execution, delivery and enforcement of this First
Amendment. The agreement set forth in this Section 5 shall survive the
termination of this First Amendment and the Amended Credit Agreement.

         SECTION 6. COUNTERPARTS. This First Amendment may be executed in any
number of counterparts, each of which shall constitute an original but all of
which when taken together shall constitute but one agreement. Delivery of an
executed counterpart of a signature page to this First Amendment by telecopier
shall be effective as delivery of a manually executed counterpart of this First
Amendment.



                                      -6-
<PAGE>   7


         SECTION 7. CREDIT AGREEMENT. Except as expressly set forth herein, the
amendments provided herein shall not by implication or otherwise limit,
constitute a waiver of, or otherwise affect the rights and remedies of the Agent
or the Lenders under the Credit Agreement, nor shall they alter, modify, amend
or in any way affect any of the terms, conditions, obligations, covenants or
agreements contained in the Credit Agreement. The amendments provided herein
shall apply and be effective only with respect to the provisions of the Credit
Agreement specifically referred to by such amendments. Except as expressly
amended herein, the Credit Agreement shall continue in full force and effect in
accordance with the provisions thereof. As used in the Credit Agreement, the
terms "Amended Agreement", "herein", "hereinafter", "hereunder", "hereto" and
words of similar import shall mean, from and after the date hereof, the Amended
Credit Agreement.



                                      -7-

<PAGE>   8

         IN WITNESS WHEREOF, each of the parties hereto has caused a counterpart
of this First Amendment to be duly executed and delivered as of the date first
above written.



BORROWER:                          KENDLE INTERNATIONAL INC.
                                   an Ohio corporation


                                   By: /s/ Timothy M. Mooney
                                       ---------------------------------------- 
                                       Name: Timothy M. Mooney
                                       Title: Vice President and CFO



LENDERS:                           NATIONSBANK, N.A.,
                                   individually in its capacity as a
                                   Lender and in its capacity as Agent and
                                   Issuing Lender


                                   By: /s/ Michael S. Sylvester
                                       ---------------------------------------- 
                                       Name: Michael S. Sylvester
                                       Title: 


                                   BANK ONE, N.A., as a Lender


                                   By: /s/ Richard Kuertz
                                       ---------------------------------------- 
                                       Name: Richard Kuertz
                                       Title: 


                                   FIFTH THIRD BANK, as a Lender


                                   By: /s/ H. Lytle Thomas
                                       ---------------------------------------- 
                                       Name: H. Lytle Thomas
                                       Title: 




<PAGE>   1

                                                                      Exhibit 13





                                    FINANCIAL REVIEW
- --------------------------------------------------------------------------------


                                    28   SELECTED FINANCIAL DATA

                                    29   QUARTERLY FINANCIAL DATA

                                    30   MANAGEMENT'S DISCUSSION AND ANALYSIS

                                    35   CONSOLIDATED STATEMENTS OF INCOME

                                    36   CONSOLIDATED BALANCE SHEETS

                                    37   CONSOLIDATED STATEMENTS OF
                                         SHAREHOLDERS' EQUITY

                                    38   CONSOLIDATED STATEMENTS OF CASH FLOWS

                                    40   NOTES TO CONSOLIDATED FINANCIAL
                                         STATEMENTS

                                    49   REPORT OF INDEPENDENT ACCOUNTANTS

                                    50   MANAGEMENT TEAM

                                    51   CORPORATE INFORMATION



                                                                             27.
<PAGE>   2


SELECTED FINANCIAL DATA

<TABLE>
<CAPTION>
(IN THOUSANDS, EXCEPT PER SHARE DATA)
FOR THE YEARS ENDED DECEMBER 31,                        1998         1997         1996         1995         1994
- ------------------------------------------------------------------------------------------------------------------
CONSOLIDATED STATEMENT OF INCOME(1)
<S>                                                 <C>          <C>          <C>          <C>          <C>       
- ------------------------------------------------------------------------------------------------------------------
Net revenues                                        $  89,516    $  44,233    $  12,959    $   6,118    $   4,431
Costs and expenses:
   Direct costs                                        46,607       23,883        6,631        2,787        2,090
   Selling, general and administrative                 27,430       13,538        4,823        2,553        1,737
   Depreciation and amortization                        4,711        1,583          316          168          127
- ------------------------------------------------------------------------------------------------------------------
                                                       78,748       39,004       11,770        5,508        3,954
- ------------------------------------------------------------------------------------------------------------------
Income from operations                                 10,768        5,229        1,189          610          477
Interest income                                         1,587          369           15            6           24
Interest expense                                         (284)        (425)         (65)         (69)         (43)
Other                                                     (13)         (59)          (5)
- ------------------------------------------------------------------------------------------------------------------
Income before income taxes and extraordinary item      12,058        5,114        1,134          547          458
Income taxes                                            4,893        1,451
- ------------------------------------------------------------------------------------------------------------------
Income before extraordinary item                        7,165        3,663        1,134          547          458
Extraordinary item, net of tax benefit                              (1,140)
- ------------------------------------------------------------------------------------------------------------------
Net income                                          $   7,165    $   2,523    $   1,134    $     547    $     458
- ------------------------------------------------------------------------------------------------------------------
Pro forma net income(2)                                          $   1,914    $     681    $     328    $     275
- ------------------------------------------------------------------------------------------------------------------

INCOME PER SHARE DATA (PRO FORMA FOR 1994 - 1997)

Basic:
   Income per share before extraordinary item       $    0.75    $    0.60    $    0.19    $    0.09    $    0.08
   Extraordinary item per share                                      (0.22)
- ------------------------------------------------------------------------------------------------------------------
   Net income per share                             $    0.75    $    0.38    $    0.19    $    0.09    $    0.08
- ------------------------------------------------------------------------------------------------------------------
   Weighted average shares                              9,589        5,055        3,650        3,650        3,650
Diluted:
   Income per share before extraordinary item       $    0.70    $    0.53    $    0.17    $    0.09    $    0.07
   Extraordinary item per share                                      (0.20)
- ------------------------------------------------------------------------------------------------------------------
   Net income per share                             $    0.70    $    0.33    $    0.17    $    0.09    $    0.07
- ------------------------------------------------------------------------------------------------------------------
   Weighted average shares                             10,226        5,763        4,017        3,852        3,804

CONSOLIDATED BALANCE SHEET DATA(1,3)

Working capital                                     $  65,496    $  20,710    $    (294)   $    (139)   $    (208)
Total assets                                          153,240       79,625        8,623        2,432        1,874
Total long-term debt                                    3,103        3,087          761          151          139
Total shareholders' equity                            122,500       50,349          944          345           51
</TABLE>

- -----------

(1)  During 1998 and 1997, the Company made three acquisitions. See Note 12 to
     the consolidated financial statements.
(2)  Pro forma net income reflects the application of corporate income taxes to
     the Company's net income at an assumed statutory combined federal, state
     and local rate which would have been recorded if the Company had been taxed
     as a C corporation during such periods.
(3)  In 1998 and 1997, the Company and its shareholders completed Common Stock
     offerings, in which the Company raised net proceeds of $51.4 million and
     $45.2 million, respectively.

28.
<PAGE>   3


QUARTERLY FINANCIAL DATA (UNAUDITED)

<TABLE>
<CAPTION>
(IN THOUSANDS, EXCEPT PER SHARE DATA)
QUARTER                                                    FIRST       SECOND        THIRD      FOURTH
- --------------------------------------------------------------------------------------------------------
1998
<S>                                                      <C>          <C>          <C>         <C>
Net revenues                                             $   19,766   $   22,534   $  22,869   $  24,347
Income from operations                                        2,307        2,604       2,754       3,103
Net income                                                    1,444        1,559       2,009       2,153
Net income per diluted share                                   0.17         0.17        0.18        0.19
Ranges of stock price
   High                                                       27.25       31.375       35.00       32.75
   Low                                                        15.00        21.75      22.875      19.875

1997

Net revenues                                             $    5,962   $    7,210   $  12,518  $   18,543
Income from operations                                          543          990       1,528       2,168
Pro forma income before extraordinary item(1)                   317          534         756       1,292
Pro forma net income (loss)(1)                                  317          534        (384)      1,292
Pro forma income per diluted share before 
   extraordinary item(1)                                       0.08         0.12        0.13        0.16
Pro forma net income (loss) per diluted share(1)               0.08         0.12       (0.06)       0.16
Ranges of stock price(2)
   High                                                                                19.00      18.625
   Low                                                                                 14.00       10.00
</TABLE>

- ------------

(1)  The pro forma data reflects the application of corporate income taxes to
     the Company's net income at an assumed statutory combined federal, state
     and local rate which would have been recorded if the Company had been taxed
     as a Corporation during such periods.
(2)  In August, 1997, the Company and its shareholders completed an initial
     public offering, with common shares offered to the public at a price of $14
     per share.

                                                                             29.
<PAGE>   4



MANAGEMENT'S DISCUSSION AND ANALYSIS



MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF
OPERATIONS

The information set forth and discussed below is derived from the Company's
Consolidated Financial Statements included herein and should be read in
conjunction therewith.


COMPANY OVERVIEW

Kendle International Inc. ("the Company") is an international contract research
organization (CRO) that provides integrated clinical research services,
including Phase I through IV drug development, on a contract basis to the
pharmaceutical and biotechnology industries.

The Company's contracts are generally fixed price, with some variable
components, and range in duration from a few months to several years. A portion
of the contract fee is typically required to be paid at the time the contract is
entered into and the balance is received in installments over the contract's
duration, in most cases on a milestone achievement basis. Net revenues from
contracts are generally recognized on the percentage of completion method,
measured principally by the total costs incurred as a percentage of estimated
total costs for each contract. The estimated total costs of contracts are
reviewed and revised periodically throughout the lives of the contracts with
adjustments to revenues resulting from such revisions being recorded on a
cumulative basis in the period in which the revisions are made. Additionally,
the Company incurs costs, in excess of contract amounts, in subcontracting with
third-party investigators. Such costs, which are reimbursable by its customers,
are excluded from direct costs and net revenues.

Direct costs consist of compensation and related fringe benefits for
project-related associates, unreimbursed project-related costs and indirect
costs including facilities, information systems and other costs. Selling,
general and administrative expenses consist of compensation and related fringe
benefits for sales and administrative associates and professional services, as
well as unallocated costs related to facilities, information systems and other
costs.

The Company's results are subject to volatility due to such factors as the
commencement, completion, cancelation or delay of contracts; the progress of
ongoing projects; cost overruns; the Company's sales cycle; the ability to
maintain large customer contracts or to enter into new contracts, and other
factors. In 1998, the Company's Phase I Unit experienced a decline in revenues
and a resulting loss from operations. The Phase I Unit results were due in part
to the inherent volatility in Phase I revenues due to the nature of Phase I
studies (shorter duration studies with shorter lead times and higher potential
for cancelation) combined with turnover in certain management personnel. The
Company has taken steps to mitigate this volatility with the hiring of
experienced Phase I management personnel and has increased its Phase I new
business development efforts. The Company is expecting revenues and related
operating performance to improve beginning in 1999. However, the decline in
revenues and resulting loss from operations in the Phase I Unit could continue
if the Company's efforts are unsuccessful.


ACQUISITIONS

The Company acquired ACER/EXCEL Inc. ("ACER/EXCEL") headquartered in Cranford,
New Jersey, in February, 1998. ACER/EXCEL provides customers with Phase II
through IV clinical services. It also provides drug development services to the
Pacific Rim, through a joint venture which operates a CRO headquartered in
Beijing, China.

The Company acquired U-Gene Research B.V. ("U-Gene") and GMI Gesellschaft fur
Angewandte Mathematik und Informatik mbH ("gmi") in June and September, 1997,
respectively.

The acquisitions have been accounted for using the purchase method of
accounting, with goodwill as a result of the transactions being amortized over
30 years. The results of operations are included in the Company's consolidated
statements of income from the dates of acquisition.


RESULTS OF OPERATIONS
NET REVENUES

Net revenues increased to $89.5 million for the year ended December 31, 1998.
This compares to $44.2 million and $13.0 million for the years ended December
31, 1997 and 1996, respectively. The 102% increase in net revenues in 1998 was
comprised of organic growth of 64% and growth 

30.
<PAGE>   5


from acquisitions of 38%. The 241% increase in net revenues in 1997 was
comprised of organic growth of 161% and growth from acquisitions of 81%.
Revenues from G.D. Searle and Co. accounted for approximately 38%, 54% and 48%
of net revenues for the years ended December 31, 1998, 1997, and 1996
respectively.


<TABLE>
<CAPTION>
NET REVENUES
                    1996      1997      1998
                    ----      ----      ----
<S>                 <C>       <C>       <C>
$ MILLIONS          13.0      44.2      89.5
</TABLE>


Operating Expenses

<TABLE>
<CAPTION>
         OPERATING EXPENSES
         $ MILLIONS                        1996        1997        1998
         ---------------------------------------------------------------
         <S>                               <C>        <C>         <C>
         Direct Costs                      $6.6       $23.9       $46.6
         Selling, general &
                  administrative            4.8        13.5        27.4
         Depreciation and
                  Amortization              0.3         1.6         4.7
</TABLE>

Direct costs increased by $22.7 million, or 95%, for the year ended December 31,
1998 as compared to 1997. As compared to 1996, direct costs increased by $17.3
million, or 260% in 1997. The increases are a result of increases in direct
salaries and fringe benefits to support the increases in net revenues for the
periods. Direct costs expressed as a percentage of net revenues decreased to
52.1% for the year ended December 31, 1998, from 54.0% in 1997. The decrease in
these costs as a percentage of net revenues is due primarily to the absorption
of direct project-related costs over a larger revenue base. Direct costs as a
percentage of net revenues in 1996 were 51.2%.

Selling, general and administrative expenses increased by $13.9 million, or
103%, for the year ended December 31, 1998 as compared to 1997. These expenses
increased $8.7 million, or 181%, for the year ended December 31, 1997 as
compared to 1996. The increases are primarily comprised of an increase in
salaries and benefits which is the result of the Company's continued efforts to
increase its infrastructure in order to support the growth in business,
including increases in rent and other facility expenses, travel, contractual
services, recruiting, marketing, advertising and other expenses. Selling,
general and administrative expenses as a percentage of net revenues were 30.6%
for the years ended December 31, 1998 and 1997 and 37.2% in 1996. The decrease
in this percentage in 1997 as compared to 1996 resulted from spreading these
expenses over a larger revenue base in 1997 as compared to 1996.

Depreciation and amortization expense increases from 1996 through 1998 are
primarily the result of the amortization of goodwill as a result of the
Company's acquisitions.

INCOME TAXES

The Company's effective tax rate was 40.6% for the year ended December 31, 1998
as compared to 28.4% in 1997. There were no income taxes recorded with respect
to periods prior to the Company's August, 1997 initial public offering ("IPO")
as the Company was taxed as an S corporation.


LIQUIDITY AND CAPITAL RESOURCES

<TABLE>
<CAPTION>
WORKING CAPITAL
                    1996      1997      1998
                    ----      ----      ----
<S>                 <C>       <C>       <C>
$ MILLIONS          (0.3)     20.7      65.5
</TABLE>

Cash and cash equivalents decreased by $1.8 million for the year ended December
31, 1998 as a result of cash provided by financing activities of $50.6 million
offset by cash used in operating and investing activities of $1.9 million and
$50.7 million, respectively. Net cash used in operating activities resulted
primarily from net income offset by additional working capital used to support
the Company's growth.

Investing activities for the year ended December 31, 1998 consisted primarily of
the costs related to the ACER/EXCEL acquisition of $12.7 million, net of cash
acquired and the purchase of available for sale securities of $42.5 million.
Financing activities for the year ended December 31, 1998 consisted primarily of
net proceeds of $51.4 million as a result of the Company's follow-on offering of
Common Stock.


                                                                             31.
<PAGE>   6


Cash and cash equivalents increased by $13.7 million for the year ended December
31, 1997 as a result of cash provided by operating and financing activities of
$6.5 million and $41.6 million, respectively, offset by cash used in investing
activities of $34.4 million. Net cash provided by operating activities resulted
primarily from net income plus the net change in working capital items.

<TABLE>
<CAPTION>
CASH, CASH EQUIVALENTS &
AVAILABLE FOR SALE SECURITIES
                                   1996      1997      1998
                                   ----      ----      ----
<S>                                <C>       <C>       <C>
$ MILLIONS                         2.0       24.2      54.3
</TABLE>

Investing activities for the year ended December 31, 1997 consisted primarily of
the costs related to the U-Gene and gmi acquisitions of $22.9 million, net of
cash acquired. Financing activities for the year ended December 31, 1997
consisted primarily of $45.2 million of net proceeds from the Company's IPO.

Cash and cash equivalents increased by $2.1 million during the year ended
December 31, 1996 as a result of $3.3 million in cash provided by operating
activities and $400,000 and $800,000 in cash used by investing and financing
activities, respectively. Net cash provided by operating activities resulted
primarily from net income plus the net change in working capital items.

The Company had available for sale securities totaling $40.8 million and $8.4
million at December 31, 1998 and 1997, respectively.

Capital expenditures were $7.3 million, $3.1 million and $500,000 in 1998, 1997,
and 1996, respectively.

The Company has a $30 million credit facility with certain banks. The credit
facility bears interest at a rate equal to either (a) LIBOR plus the Applicable
Percentage (as defined) or (b) the higher of the Bank's prime rate or the
Federal Funds rate plus 0.50%, plus the Applicable Percentage. All amounts
outstanding thereunder become due and payable in February, 2001. The facility
includes various restrictive covenants including the maintenance of certain
fixed coverage and leverage ratios as well as minimum net worth levels. At
December 31, 1998, there were no amounts outstanding under the credit facility.

In January, 1999, the Company acquired Research Consultants (International)
Holdings Ltd. ("IRC") for $4.1 million in cash and 87,558 shares of the
Company's Common Stock. The acquisition was funded from existing cash.

Additionally, in January, 1999, the Company acquired a minority interest in
Component Software International, Inc. ("CSI"), a software consulting and
development company, for $1.6 million and 19,995 shares of the Company's Common
Stock. Concurrent with this transaction, the Company entered into a Multi-Year
Strategic Service Agreement with CSI whereby the Company will pay CSI $7.0
million over the next four years in exchange for strategic software consulting
and development services.

The Company's primary cash needs on both a short-term and long-term basis are
for the payment of salaries and fringe benefits, hiring and recruiting expenses,
business development costs, capital expenditures, acquisitions, and facility
related expenses. The Company believes that its existing capital resources,
together with cash flows from operations and borrowing capacity under its credit
facility, will be sufficient to meet its foreseeable cash needs. In the future,
the Company will continue to consider acquiring businesses to enhance its
service offerings, therapeutic base and global presence. Any such acquisitions
may require additional external financings and the Company may from time to time
seek to obtain funds from public or private issuances of equity or debt
securities. There can be no assurance that such financings will be available on
terms acceptable to the Company.


IMPACT OF THE YEAR 2000

The Year 2000 Issue is the result of computer programs being written using two
digits rather than four to define the applicable year. Any of the Company's
computer programs that have date-sensitive software may recognize a date using
"00" as the year 1900 rather than the year 2000. This could result in a system
failure or miscalculations causing disruptions of operations, including, among
other things, a temporary inability to process transactions, send invoices, or
engage in similar normal business activities.

32.
<PAGE>   7


The Company has a detailed plan in place to address the Year 2000 Issue. The
Company has formed an ongoing internal review team to address the Year 2000
Issue that encompasses personnel from various operational and administrative
areas of the Company and involved the engagement of an outside consultant.
Progress against the Year 2000 plan is monitored by this internal review team
and reported to senior management and the Board of Directors on a regular basis.
The project has proceeded according to plan thus far.

The Company's Year 2000 plan encompasses the following: (a) inventory and
assessment, (b) remediation, and (c ) validation and implementation. To date,
the Company's key financial and operational systems have been inventoried and
detailed plans are in place for the required systems modifications or
replacements. Implementation of required changes to critical business systems,
including testing of those changes, is substantially complete. The remainder of
the plan, including remediation of certain European clinical data management
systems, is expected to be an ongoing activity in 1999, with completion expected
by September 30, 1999.

The Company has initiated formal communications with its suppliers and customers
to determine the extent to which the Company is vulnerable to those third
parties' failure to remediate their own Year 2000 Issue. These suppliers include
utility companies, telecommunications companies and business specific product
suppliers such as software and hardware providers and Phase I Unit equipment
providers. To date, responses have been received from approximately 51% of the
Company's inventory of suppliers. There can be no guarantee that the systems of
other companies on which the Company's systems rely will be converted in a
timely manner, or that a failure to convert by another company, or a conversion
that is incompatible with the Company's systems, would not have a material
adverse effect on the Company.

Incremental costs, which include contractor costs to modify existing systems and
costs of internal resources involved in achieving Year 2000 compliance, are
charged to expense as incurred. The Company has utilized both internal and
external resources to reprogram or replace and test the software for Year 2000
modifications. Costs for the Year 2000 project have increased through our
remediation and testing efforts and are now estimated to total $800,000, of
which approximately 50% has been spent through December 31, 1998. Approximately
$200,000 of the $400,000 of costs which remain relate to the replacement of
certain of the Company's noncritical business systems.

The costs of the project and the date on which the Company plans to complete the
Year 2000 modifications are based on management's best estimates, which were
derived utilizing numerous assumptions of future events including the continued
availability of certain resources, third party modification plans and other
factors. However, there can be no guarantee that these estimates will be
achieved and actual results could differ materially from those plans. Specific
factors that might cause such material differences include, but are not limited
to, the availability and cost of personnel trained in this area, the ability to
locate and correct all relevant computer codes, and the ability of third parties
with whom we have business relationships to successfully address their own Year
2000 concerns.

The Company's risk management program includes emergency backup and recovery
procedures to be followed in the event of failure of a business critical system.
These procedures will be expanded to include specific procedures for potential
Year 2000 Issues. Contingency plans to protect the business from Year 2000
related interruptions are being developed. The Company expects these plans to be
completed during the second quarter of 1999 and they will include, for example,
development of backup procedures and identification of alternative suppliers.

Worst-case scenarios resulting from Year 2000 problems could include the
following: loss of electrical, water and other utility services which could
result in disruption of the Company's services, software and embedded technology
failure which could disrupt the Company's equipment, systems and networks
resulting in an inability to perform existing and future studies and/or an
adverse impact on the health and well being of patients; the loss of
telecommunications capabilities (both voice and data), which


                                                                             33.
<PAGE>   8


could result in an inability of the Company to internally communicate or to
communicate with, among others, its customers and investigational sites; and the
inability of the Company's third party investigational sites to become Year 2000
compliant, which could result in the loss to the Company of their services. As
previously discussed, the Company is currently in the process of developing
contingency plans to address the consequences of these issues, should they
arise. These or other events could result in business slowdowns or suspensions
and have a material adverse effect on the Company's business, financial
condition, results of operations or cash flows.


NEW ACCOUNTING PRONOUNCEMENTS

In March, 1998, the American Institute of Certified Public Accountants issued
Statement of Position ("SOP") 98-1 "Accounting for the Costs of Computer
Software Developed or Obtained for Internal Use." This statement defines the
accounting for computer software developed or obtained (purchased) for internal
use, including (1) a requirement to capitalize specified costs as a long-lived
asset, (2) amortization of such amounts, and (3) recognition and measurement of
impairment of those amounts. The Company adopted the SOP beginning January 1,
1999. The adoption of this SOP had no impact on the consolidated financial
statements.

In June, 1998, the Financial Accounting Standards Board ("FASB") issued
Statement of Financial Accounting Standards ("SFAS") No. 133, "Accounting for
Derivative Instruments and Hedging Activities." SFAS No. 133 is effective for
all fiscal quarters of all fiscal years beginning after June 15, 1999 (January
1, 2000 for the Company). SFAS No. 133 requires that all derivative instruments
be recorded on the balance sheet at their fair value. Changes in the fair value
of derivatives are recorded each period in current earnings or other
comprehensive income, depending on whether a derivative is designated as part of
a hedge transaction and, if it is, the type of hedge transaction. Since its only
derivative transaction has historically been the use of foreign currency
exchange rate hedge instruments from time to time within a year, management of
the Company anticipates that the adoption of SFAS No. 133 will not have a
significant effect on the Company's results of operations or its financial
position.


CAUTIONARY STATEMENT FOR FORWARD-LOOKING INFORMATION

Certain statements contained in this Annual Report that are not historical facts
constitute forward-looking statements, within the meaning of the Private
Securities Litigation Reform Act of 1995, and are intended to be covered by the
safe harbors created by that Act. Reliance should not be placed on
forward-looking statements because they involve known and unknown risks,
uncertainties and other factors which may cause actual results, performance or
achievements to differ materially from those expressed or implied. Any
forward-looking statement speaks only as of the date made. The Company
undertakes no obligation to update any forward-looking statements to reflect
events or circumstances arising after the date on which they are made.

Statements concerning expected financial performance, on-going business
strategies and possible future action which the Company intends to pursue to
achieve strategic objectives constitute forward-looking information.
Implementation of these strategies and the achievement of such financial
performance are each subject to numerous conditions, uncertainties and risk
factors. Factors which could cause actual performance to differ materially from
these forward-looking statements include, without limitation, factors discussed
in conjunction with a forward-looking statement, changes in general economic
conditions, the ability of the combined businesses to be integrated with the
Company's operations, the Company's ability to meet deadlines regarding Year
2000 readiness, ability to penetrate new markets, the ability of joint venture
businesses to be integrated with the Company's operations, and the ability to
maintain large customer contracts or to enter into new contracts, and the other
risk factors set forth in the Company's SEC filings, copies of which are
available upon request from the Company's investor relations department.


34.
<PAGE>   9


CONSOLIDATED STATEMENTS OF INCOME

<TABLE>
<CAPTION>
FOR THE YEARS ENDED DECEMBER 31,                                  1998            1997            1996
- ---------------------------------------------------------------------------------------------------------
<S>                                                          <C>             <C>             <C>         
Net revenues                                                 $ 89,516,138    $ 44,232,899    $ 12,959,054
Cost and expenses:                                           
   Direct costs                                                46,606,625      23,882,725       6,630,916
   Selling, general and administrative                         27,430,414      13,537,870       4,823,390
   Depreciation and amortization                                4,711,258       1,583,521         315,541
- ---------------------------------------------------------------------------------------------------------
                                                               78,748,297      39,004,116      11,769,847
- ---------------------------------------------------------------------------------------------------------
Income from operations                                         10,767,841       5,228,783       1,189,207
Other income (expense):                                      
   Interest income                                              1,586,904         368,768          14,746
   Interest expense                                              (284,219)       (424,768)        (65,127)
   Other                                                          (12,340)        (59,053)         (4,470)
- ---------------------------------------------------------------------------------------------------------
                                                                1,290,345        (115,053)        (54,851)
Income before income taxes and extraordinary item              12,058,186       5,113,730       1,134,356
Income taxes                                                    4,893,117       1,451,184
- ---------------------------------------------------------------------------------------------------------
Income before extraordinary item                                7,165,069       3,662,546       1,134,356
                                                             
Extraordinary item, net of tax benefit                                         (1,139,823)
- ---------------------------------------------------------------------------------------------------------
Net income                                                   $  7,165,069    $  2,522,723    $  1,134,356
Pro forma income data:                                       
   Income before extraordinary item                                          $  3,662,546    $  1,134,356
   Pro forma adjustment for income taxes                                          608,777         453,742
- ---------------------------------------------------------------------------------------------------------
   Pro forma income before extraordinary item                                   3,053,769         680,614
   Extraordinary item, net of tax benefit                                      (1,139,823)
- ---------------------------------------------------------------------------------------------------------
   Pro forma net income                                                      $  1,913,946    $    680,614
Income per share data (pro forma for 1997 and 1996):         
Basic:                                                       
   Income per share before extraordinary item                $       0.75    $       0.60    $       0.19
   Extraordinary item per share                                                     (0.22)
- ---------------------------------------------------------------------------------------------------------
   Net income per share                                      $       0.75    $       0.38    $       0.19
- ---------------------------------------------------------------------------------------------------------
   Weighted average shares                                      9,588,915       5,055,452       3,650,000
Diluted:                                                     
   Income per share before extraordinary item                $       0.70    $       0.53    $       0.17
   Extraordinary item per share                                                     (0.20)
- ---------------------------------------------------------------------------------------------------------
   Net income per share                                      $       0.70    $       0.33    $       0.17
- ---------------------------------------------------------------------------------------------------------
   WEIGHTED AVERAGE SHARES                                     10,226,352       5,763,308       4,017,493
</TABLE>


                                                                             35.
<PAGE>   10


CONSOLIDATED BALANCE SHEETS


<TABLE>
<CAPTION>
DECEMBER 31,                                                                  1998             1997
- ------------------------------------------------------------------------------------------------------
ASSETS
<S>                                                                     <C>              <C>          
Current assets:
   Cash and cash equivalents                                            $  13,980,300    $  15,766,963
   Available for sale securities                                           40,768,460        8,438,650
   Accounts receivable                                                     28,517,542       15,027,791
   Unreimbursed investigator and project costs                              4,072,214        5,174,967
   Other current assets                                                     4,051,540        1,845,297
- ------------------------------------------------------------------------------------------------------
      Total current assets                                                 91,390,056       46,253,668
Property and equipment, net                                                11,319,793        6,194,692
Excess of purchase price over net assets acquired, net                     47,691,537       25,929,433
Other assets                                                                2,838,496        1,246,815
- ------------------------------------------------------------------------------------------------------
         Total assets                                                   $ 153,239,882    $  79,624,608

LIABILITIES AND SHAREHOLDERS' EQUITY

Current liabilities:
   Current portion of obligations under capital leases                  $     910,273    $     627,836
   Trade payables                                                           6,252,061        9,837,358
   Advances against investigator and project costs                          2,695,608        1,303,310
   Advance billings                                                         9,722,037        8,066,286
   Accrued compensation and related payroll withholdings and taxes          3,699,690        2,261,752
   Income taxes payable                                                       835,069        1,413,993
   Other Accrued Liabilities                                                1,779,515        2,032,760
- ------------------------------------------------------------------------------------------------------
      Total current liabilities                                            25,894,253       25,543,295
Obligations under capital leases, less current portion                      1,512,680        1,617,256
Note payable                                                                1,590,000        1,470,000
Other liabilities                                                           1,742,902          645,248
- ------------------------------------------------------------------------------------------------------
      Total liabilities                                                    30,739,835       29,275,799

Shareholders' equity:
   Preferred stock--no par value; 100,000 shares
      authorized; none outstanding
   Common stock--no par value; 15,000,000 shares authorized;
      10,955,390 and 7,582,367 shares issued and outstanding at
      December 31, 1998 and 1997, respectively                                 75,000           75,000
   Additional paid-in capital                                             114,425,511       50,186,639
   Retained earnings                                                        7,517,039          351,970
   Accumulated other comprehensive income:
      Net unrealized holdings losses on available for sale securities         (81,806)            (759)
      Foreign currency translation adjustment                                 564,303         (264,041)
- ------------------------------------------------------------------------------------------------------
         Total accumulated other comprehensive income                         482,497         (264,800)
- ------------------------------------------------------------------------------------------------------
      Total shareholders' equity                                          122,500,047       50,348,809
- ------------------------------------------------------------------------------------------------------
         Total liabilities and shareholders' equity                     $ 153,239,882    $  79,624,608
</TABLE>


The accompanying notes are an integral part of these consolidated financial 
statements.

36. 
<PAGE>   11


CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY

<TABLE>
<CAPTION>
                                                                                           ACCUMULATED
                                          COMMON STOCK      ADDITIONAL                        OTHER         TOTAL
                                   NUMBER                    PAID-IN          RETAINED    COMPREHENSIVE  SHAREHOLDERS' COMPREHENSIVE
                                  OF SHARES       AMOUNT     CAPITAL          EARNINGS        INCOME        EQUITY         INCOME
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                               <C>            <C>       <C>              <C>           <C>           <C>            <C>
Balance, January 1, 1996          3,650,000      $75,000   $    270,396                                 $   345,396
                                                                            
Net income and comprehensive                                                
       income                                                               $ 1,134,356                   1,134,356     $1,134,356
                                                                            
Distributions to shareholders                                                  (535,291)                   (535,291)
- --------------------------------------------------------------------------------------------------------------------
Balance, December 31, 1996        3,650,000       75,000        270,396         599,065                     944,461
                                                                            
Net income                                                                    2,522,723                   2,522,723     $2,522,723
                                                                            
Other comprehensive income:                                                 
                                                                            
   Foreign currency translation                                             
       adjustment                                                                         $(264,041)       (264,041)      (264,041)
                                                                            
   Net unrealized holdings                                                  
      gains on available for                                                
      sale securities, net of tax                                                            35,031          35,031         35,031
                                                                            
   Reclassification adjustment                                              
      for holdings gains included                                           
      in net income, net of tax                                                             (35,790)        (35,790)       (35,790)
- ------------------------------------------------------------------------------------------------------------------------------------
Comprehensive income                                                                                                    $2,257,923
- ------------------------------------------------------------------------------------------------------------------------------------
DISTRIBUTIONS TO SHAREHOLDERS                                                (2,308,350)                 (2,308,350)
                                                                            
Reclassification of S corporation                                           
   retained earnings to                                                     
   additional paid-in capital                                   461,468        (461,468)
                                                                            
Net proceeds from sale of                                                   
   Common Stock                   3,540,000                  45,198,032                                  45,198,032
                                                                            
Issuance of Common Stock in                                                 
   connection with the                                                      
   acquisition of gmi               191,304                   2,678,256                                   2,678,256
                                                                            
Warrants issued and subsequently                                            
   converted                        153,738                   1,501,537                                   1,501,537
                                                                            
Shares issued under stock plans      47,325                      43,048                                      43,048
                                                                            
Income tax benefit from exercise                                            
   of stock options                                              33,902                                      33,902
- --------------------------------------------------------------------------------------------------------------------
Balance, December 31, 1997        7,582,367       75,000     50,186,639         351,970    (264,800)     50,348,809
                                                                            
Net income                                                                    7,165,069                   7,165,069     $7,165,069
                                                                            
Other comprehensive income:                                                 
                                                                            
   Foreign currency translation                                             
      adjustment                                                                            828,344         828,344        828,344
                                                                            
   Net unrealized holdings gains                                            
      on available for sale                                                 
      securities, net of tax                                                                 38,660          38,660         38,660
                                                                            
   Reclassification adjustment                                              
      for holdings gains included                                           
      in net income, net of tax                                                            (119,707)       (119,707)      (119,707)
- ------------------------------------------------------------------------------------------------------------------------------------
Comprehensive income                                                                                                    $7,912,366
- ------------------------------------------------------------------------------------------------------------------------------------
Net proceeds from sale of                                                   
   Common Stock                   2,315,000                  51,370,656                                  51,370,656
                                                                            
Issuance of Common Stock in                                                 
   connection with the                                                      
   acquisition of ACER/EXCEL        987,574                  12,542,190                                  12,542,190
                                                                            
Shares issued under stock plans      70,449                     130,561                                     130,561
                                                                            
Income tax benefit from exercise                                            
   of stock options                                             195,465                                     195,465
- --------------------------------------------------------------------------------------------------------------------
Balance, December 31, 1998       10,955,390      $75,000   $114,425,511      $7,517,039    $482,497    $122,500,047
</TABLE>                                                                


The accompanying notes are an integral part of these consolidated financial
statements.                                                                 

                                                                             37.

<PAGE>   12


CONSOLIDATED STATEMENTS OF CASH FLOWS


<TABLE>
<CAPTION>
FOR THE YEARS ENDED DECEMBER 31,                                  1998            1997            1996
- ---------------------------------------------------------------------------------------------------------
CASH FLOWS FROM OPERATING ACTIVITIES
<S>                                                          <C>             <C>             <C>         
   Net income                                                $  7,165,069    $  2,522,723    $  1,134,356
   Adjustments to reconcile net income to cash provided
         by (used in) operating activities:
   Depreciation and amortization                                4,711,258       1,583,521         315,541
   Deferred income taxes                                          718,571         245,465
   Extraordinary item, net of tax                                               1,139,823
   Other                                                          (53,708)        (31,205)
   Changes in operating assets and liabilities, net of
         effects from acquisitions:
      Accounts receivable                                     (10,866,727)     (6,079,930)     (1,927,921)
      Other current assets                                     (1,110,703)       (388,014)         25,007
      Other assets                                                (51,949)       (140,903)       (116,186)
      Investigator and project costs                            2,527,687      (3,667,626)       (838,857)
      Trade payables                                           (4,262,157)      7,048,641         659,821
      Advance billings                                           (202,792)      1,292,162       3,906,574
      Accrued liabilities and other                              (452,340)      2,955,261         162,636
- ---------------------------------------------------------------------------------------------------------
Net cash provided by (used in) operating activities            (1,877,791)      6,479,918       3,320,971

CASH FLOWS FROM INVESTING ACTIVITIES

   Purchase of available for sale securities                  (42,529,666)    (10,938,650)
   Proceeds from maturity of available for sale securities     12,121,736       2,500,000
   Acquisitions of property and equipment                      (5,830,300)     (2,545,164)       (406,974)
   Additions to internally developed software                  (1,432,581)       (531,243)        (40,005)
   Acquisitions of businesses, less cash acquired             (12,675,466)    (22,872,203)
   Other investments                                             (359,601)
- ---------------------------------------------------------------------------------------------------------
Net cash used in investing activities                         (50,705,878)    (34,387,260)       (446,979)

CASH FLOWS FROM FINANCING ACTIVITIES

   Net proceeds from sale of common stock                      51,370,656      45,198,032
   Proceeds from exercise of stock options                        119,561          43,048
   Debt issue costs                                               (59,582)       (538,698)
   Borrowings under line of credit                                              3,100,000       4,267,000
   Repayments under line of credit                                             (3,100,000)     (4,587,000)
   Borrowings under senior credit facility                                     10,745,439
   Repayment of senior credit facility                                        (10,745,439)
   Proceeds from subordinated debt borrowings                                   3,500,000
   Proceeds from issuance and conversion of stock                          
         purchase warrants                                                      1,501,537
   Repayment of subordinated debt borrowings                                   (5,000,000)
   Payments on capital lease obligations                        (845,908)        (513,196)       (236,492)
   Distributions to shareholders                                               (2,558,350)       (285,291)
- ---------------------------------------------------------------------------------------------------------
Net cash provided by (used in) financing activities          $50,584,727     $ 41,632,373    $   (841,783)
</TABLE>

38.
                                   continued
<PAGE>   13


<TABLE>
<CAPTION>
FOR THE YEARS ENDED DECEMBER 31,                                 1998             1997           1996
- --------------------------------------------------------------------------------------------------------
<S>                                                          <C>             <C>              <C>
   Effects of exchange rates on cash and cash equivalents   $    212,279     $     (5,544)
- --------------------------------------------------------------------------------------------------------
   Net increase (decrease) in cash and cash equivalents       (1,786,663)      13,719,487     $2,032,209
Cash and cash equivalents
   Beginning of year                                          15,766,963        2,047,476         15,267
- --------------------------------------------------------------------------------------------------------
   End of year                                               $13,980,300     $ 15,766,963     $2,047,476

SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION

   Cash paid during the year for interest                   $    294,890     $    424,768     $   65,127
   Cash paid during the year for income taxes               $  5,177,087     $    479,973

SUPPLEMENTAL SCHEDULE OF NONCASH INVESTING
AND FINANCING ACTIVITIES

   Acquisition of equipment under capital leases            $     75,337     $  1,637,056     $1,116,418
   Dividends declared and payable                                                             $  250,000
   Note payable under escrow agreement for
         acquisition of U-Gene                                               $  1,530,000
   Interest on note payable under escrow agreement
         for acquisition of U-Gene                                           $    180,000
   Acquisitions of businesses:
      Fair value of assets acquired                         $ 30,193,345     $ 34,750,659
      Fair value of liabilities assumed or incurred           (4,975,689)      (9,200,200)
      Stock issued                                           (12,542,190)      (2,678,256)
- --------------------------------------------------------------------------------------------------------
         Net cash payments                                  $ 12,675,466     $ 22,872,203
</TABLE>


The accompanying notes are an integral part of these consolidated financial
statements.
                                                                             39.

<PAGE>   14


NOTES TO CONSOLIDATED FINANCIAL STATEMENTS


1. NATURE OF BUSINESS AND SIGNIFICANT ACCOUNTING POLICIES:

NATURE OF BUSINESS

Kendle International Inc. (the "Company") is an international contract research
organization ("CRO") providing integrated clinical research services, including
Phase I through IV drug development, on a contract basis to the pharmaceutical
and biotechnology industries. The Company has operations in North America,
Europe and Asia.

PRINCIPLES OF CONSOLIDATION AND ORGANIZATION

The consolidated financial statements include the financial information of
Kendle International Inc. and its wholly-owned subsidiaries. Investments in
unconsolidated companies which are at least 20% owned are carried at cost plus
equity in undistributed earnings since acquisition.

All intercompany accounts and transactions have been eliminated. The results of
operations of the Company's wholly-owned subsidiaries have been included in the
consolidated financial statements of the Company from the respective dates of
acquisition.

Certain amounts reflected in the prior years' consolidated financial statements
have been reclassified to be comparable with the current year.

FOREIGN CURRENCY TRANSLATION

Assets and liabilities of the Company's wholly-owned subsidiaries are translated
into U.S. dollars at year-end exchange rates. Income statement accounts are
translated at average exchange rates for the year. These translation adjustments
are recorded as a separate component of shareholders' equity. Foreign currency
transaction gains and losses are included in the consolidated statements of
income.

As a significant percentage of the Company's cash flow from operations is
derived from operations outside the United States, the Company will be subject
to the risks of currency exchange rate fluctuations.

CASH AND CASH EQUIVALENTS

Cash and cash equivalents consist of demand deposits and money market funds held
with a financial institution, with an initial maturity of three months or less.

The Company maintains its demand deposits with certain financial institutions.
The balance of one account from time-to-time exceeds the maximum U.S. federally
insured amount. Additionally, there is no state insurance coverage on bank
balances held in The Netherlands.

AVAILABLE FOR SALE SECURITIES

Investments purchased with initial maturities greater than three months are
classified as available for sale securities and consist of highly liquid debt
securities. These securities are stated in the consolidated financial statements
at market value. Realized gains and losses are included in the consolidated
statements of income, calculated based on the weighted average cost of the
investments. Unrealized gains and losses, net of tax, are reported as a separate
component of shareholders' equity.

REVENUE RECOGNITION

Revenues are earned by performing services primarily under fixed-price
contracts. Net revenues from contracts are generally recognized on the
percentage of completion method, measured principally by the total costs
incurred as a percentage of estimated total costs for each contract. This method
is used because management considers total costs incurred to be the best
available measure of progress on these contracts. The estimated total costs of
contracts are reviewed and revised periodically throughout the lives of the
contracts with adjustment to revenues resulting from such revisions being
recorded on a cumulative basis in the period in which the revisions are made.
Hence, the effect of the changes on future periods of contract performance is
recognized as if the revised estimates had been the original estimates. Because
of the inherent uncertainties in estimating costs, it is at least reasonably
possible that the estimates used will change in the near term and could result
in a material change.


40.
<PAGE>   15


Contract costs include direct labor costs and indirect costs related to contract
performance, such as indirect labor, supplies, depreciation, rent and utilities.
Selling, general, and administrative costs are charged to expense as incurred.
Provisions for estimated losses on uncompleted contracts are recognized in the
period in which such losses become known.

Amendments to contracts resulting in revisions to revenues and costs are
recognized in the period in which the revisions are negotiated. Included in
accounts receivable are unbilled accounts receivable, which represent revenue
recognized in excess of amounts billed. Advance billings represent amounts
billed in excess of revenue recognized.

PROPERTY AND EQUIPMENT

Property and equipment are stated at cost. Depreciation is computed over
estimated useful lives of two to ten years using the straight-line method.
Repairs and maintenance are charged to expense as incurred. Upon disposition,
the asset and the related accumulated depreciation are relieved and any gains or
losses are reflected in operations.

Equipment under capital leases is recorded at the present value of future
minimum lease payments and is amortized over the estimated useful lives of the
assets, not to exceed the terms of the related leases. Accumulated amortization
on equipment under capital leases was $1,880,053 and $898,122 at December 31,
1998 and 1997, respectively.

INTERNALLY DEVELOPED SOFTWARE

The Company capitalizes costs incurred to internally develop software used
primarily in the Company's proprietary clinical trial and data management, and
amortizes these costs on a straight-line basis over the estimated useful life of
the product, not to exceed five years. Unamortized software costs included in
the consolidated balance sheets at December 31, 1998 and 1997 were $2,003,829
and $571,248, respectively. The related accumulated amortization at December 31,
1998 and 1997 was $236,524 and $53,196, respectively.

EXCESS OF PURCHASE PRICE OVER NET ASSETS ACQUIRED

The excess of cost over the fair value of the net assets acquired in the
Company's acquisitions is being amortized on a straight-line basis over a thirty
year period. Excess of purchase price over net assets acquired will be evaluated
periodically as events or circumstances indicate a possible inability to recover
their carrying amount. Such evaluation will be based on various analyses,
including cash flow and profitability projections that incorporate, as
applicable, the impact on existing company businesses. The analyses will
necessarily involve significant management judgment to evaluate the capacity of
an acquired business to perform within projections. If future expected
undiscounted cash flows are insufficient to recover the carrying amount of the
asset, an impairment loss will be recognized based on discounted expected future
cash flows. Accumulated amortization of the excess of purchase price over net
assets acquired was $1,965,816 and $376,930 at December 31, 1998 and 1997,
respectively.

INVESTIGATOR AND PROJECT COSTS

In addition to various contract costs previously described, the Company incurs
costs, in excess of contract amounts, which are reimbursable by its customers.
Such pass-through costs incurred, but not yet reimbursed, are reflected as a
current asset in the accompanying consolidated balance sheets. Advances from
customers for such costs not yet incurred are reflected as a current liability.
Such costs and reimbursement for such costs are excluded from direct costs and
net revenues and totaled $41,608,579, $48,657,085 and $3,043,802 for the years
ended December 31, 1998, 1997, and 1996, respectively.

NET INCOME PER SHARE DATA

Net income per basic share is computed using the weighted average common shares
outstanding. Net income per diluted share is computed using the weighted average
common shares and potential common shares outstanding.


                                                                             41.
<PAGE>   16



The weighted average shares used in computing net income per diluted share have
been calculated as follows:

<TABLE>
<CAPTION>
                                      1998         1997         1996
         --------------------------------------------------------------
         <S>                       <C>           <C>          <C>
         Weighted average
           common shares
           outstanding              9,588,915    5,055,452    3,650,000
         Stock purchase warrants                    97,718      153,738
         Stock options                637,437      610,138      213,755
         --------------------------------------------------------------
         Weighted average shares   10,226,352    5,763,308    4,017,493
</TABLE>

INCOME TAXES

In August, 1997, upon terminating its S corporation
status, the Company recorded deferred taxes in accordance with Statement of
Financial Accounting Standards ("SFAS") No. 109, "Accounting for Income Taxes."
In accordance with SFAS No. 109, the Company records deferred tax assets and
liabilities based on temporary differences between the financial statement and
tax bases of assets and liabilities using enacted tax rates in effect in the
year in which the differences are expected to reverse.

For periods prior to August, 1997, the consolidated financial statements of the
Company do not include a provision for income taxes because taxable income or
loss of the Company was included in the income tax returns of the individual
shareholders under the S corporation election. The consolidated statements of
income include the pro forma income tax provision on taxable income for
financial reporting purposes using statutory federal, state and local rates that
would have resulted had the Company filed corporate tax returns during these
periods.

STOCK OPTIONS

The Company accounts for stock options issued to associates in accordance with
Accounting Principles Board Opinion (APB) No. 25, "Accounting for Stock Issued
to Employees." Under APB No. 25, the Company recognized expense based on the
intrinsic value of the options.

USE OF ESTIMATES

The preparation of consolidated financial statements in conformity with
generally accepted accounting principles requires management to make estimates
and assumptions that affect the reported amounts of assets and liabilities and
disclosure of contingent assets and liabilities at the date of the consolidated
financial statements and the reported amounts of revenues and expenses during
the reporting period. Actual results could differ from those estimates.

NEW ACCOUNTING PRONOUNCEMENTS

In March, 1998, the American Institute of Certified Public Accountants issued
Statement of Position ("SOP") 98-1 "Accounting for the Costs of Computer
Software Developed or Obtained for Internal Use." This statement defines the
accounting for computer software developed or obtained (purchased) for internal
use, including (1) a requirement to capitalize specified costs as a long-lived
asset, (2) amortization of such amounts, and (3) recognition and measurement of
impairment of those amounts. The Company adopted the SOP beginning January 1,
1999. The adoption of this SOP had no impact on the consolidated financial
statements. 

In June, 1998, the Financial Accounting Standards Board ("FASB") issued SFAS No.
133, "Accounting for Derivative Instruments and Hedging Activities." SFAS No.
133 is effective for all fiscal quarters of all fiscal years beginning after
June 15, 1999 (January 1, 2000 for the Company). SFAS No. 133 requires that all
derivative instruments be recorded on the balance sheet at their fair value.
Changes in the fair value of derivatives are recorded each period in current
earnings or other comprehensive income, depending on whether a derivative is
designated as part of a hedge transaction and, if it is, the type of hedge
transaction. Since its only derivative transaction has historically been the use
of foreign currency exchange rate hedge instruments from time to time within a
year, management of the Company anticipates that the adoption of SFAS No. 133
will not have a significant effect on the Company's results of operations or its
financial position.


42.
<PAGE>   17



2. AVAILABLE FOR SALE SECURITIES:

The fair value of available for sale securities is estimated based on quoted
market prices. Information related to the Company's available for sale
securities at December 31, 1998 and 1997 is as follows:

<TABLE>
<CAPTION>
                                                            UNREALIZED           FAIR                       
                                              COST             LOSS              VALUE
         --------------------------------------------------------------------------------
         <S>                               <C>              <C>               <C>        
         1998
         Debt securities:
         Municipal securities              $40,850,266      $(81,806)         $40,768,460

         1997
         Debt securities:
         U.S. government obligations         8,439,409          (759)           8,438,650
         --------------------------------------------------------------------------------
</TABLE>

Contractual maturities of debt securities are as follows at December 31, 1998:

<TABLE>
<CAPTION>
                                           COST                 FAIR VALUE
         ------------------------------------------------------------------
         <S>                            <C>                    <C>        
         Due within one year            $    50,000            $    49,999
         Due after one year through                            
                  five years             18,489,192             18,510,730
         Due after five years through                          
                  ten years              22,311,074             22,207,731
         ------------------------------------------------------------------
         Total debt securities          $40,850,266            $40,768,460
</TABLE>

Proceeds from the maturities of investments in securities were $12,121,736 and
$2,500,000 in 1998 and 1997, respectively. Gross gains realized on these
maturities were $119,707 and $35,790 during 1998 and 1997, respectively.


3. FAIR VALUE OF FINANCIAL INSTRUMENTS:

The carrying amounts of the Company's financial instruments, including cash and
cash equivalents, available for sale securities, and notes payable, approximate
their fair value.


4. ACCOUNTS RECEIVABLE:

Accounts receivable are billed when certain milestones defined in customer
contracts are achieved. All unbilled accounts receivable are expected to be
collected within one year.

<TABLE>
<CAPTION>
         DECEMBER 31,              1998                1997
         ------------------------------------------------------
         <S>                   <C>                 <C>        
         Billed                $20,269,243         $11,095,821
         Unbilled                8,248,299           3,931,970
         ------------------------------------------------------
                               $28,517,542         $15,027,791
</TABLE>                                    


5. PROPERTY AND EQUIPMENT:

Property and equipment is summarized as follows:

<TABLE>
<CAPTION>
         DECEMBER 31,                           1998                1997
         -------------------------------------------------------------------
         <S>                                <C>                 <C>        
         Furnishings, equipment and other   $12,068,633         $ 5,126,862
         Equipment under capital leases       4,289,870           3,225,190
         Less: accumulated depreciation
                  and amortization           (5,038,710)         (2,157,360)
         -------------------------------------------------------------------
         Property and equipment, net        $11,319,793         $ 6,194,692
</TABLE>

Depreciation expense for the years ended December 31, 1998, 1997, and 1996 was
$1,839,278, $531,357, and $118,809, respectively.


6. DEBT:

The Company has a $30 million credit facility (the "Amended and Restated Senior
Credit Facility") which bears interest at either LIBOR plus the Applicable
Percentage (as defined) or the higher of the bank's prime rate or the Federal
Funds rate plus 0.50%, plus the Applicable Percentage. All amounts outstanding
thereunder are payable in February, 2001. The Amended and Restated Senior Credit
Facility contains various restrictive financial covenants, including the
maintenance of certain fixed coverage and leverage ratios and minimum net worth
levels. At December 31, 1998, there were no amounts outstanding under this
credit facility.


7. EMPLOYEE BENEFIT PLANS:

401(K) PLAN

The Company maintains a 401(k) retirement plan covering substantially all U.S.
associates who have completed at least six months of service and meet minimum
age requirements. The Company makes a matching contribution of 25% of each
participant's contribution of up to 6% 


                                                                             43.
<PAGE>   18


of salary. The Company's matching contribution to this plan totaled $238,885 and
$30,809 for the years ended December 31, 1998 and 1997, respectively.

INCENTIVE STOCK OPTION AND STOCK INCENTIVE PLAN

In 1997, the Company established a plan that provides for the grant of up to
1,000,000 stock options, consisting of both incentive and non-qualified stock
options (the "1997 Plan"). Participation in the 1997 Plan is at the discretion
of the Board of Director's Compensation Subcommittee, which is responsible for
administration of the Plan. The exercise price of incentive stock options
granted under the 1997 Plan must be no less than the fair market value of the
Common Stock, as determined under the 1997 Plan provisions, at the date the
option is granted (110% of fair market value for shareholders owning more than
10% of the Company's Common Stock). The exercise price of non-qualified stock
options must be no less than 95% of the fair market value of the Common Stock at
the date the option is granted. The vesting provisions of the options granted
under the 1997 Plan are determined at the discretion of the Compensation
Subcommittee of the Board of Directors. The options generally expire either 90
days after termination of employment or, if earlier, ten years after date of
grant. No options can be granted after August, 2007. The Company has reserved
1,000,000 shares of Common Stock for the 1997 Plan, of which 475,822 are
available for grant at December 31, 1998.

The 1997 Plan replaced a similar plan under which 591,055 options were
outstanding at December 31, 1998.

Aggregate stock option activity during 1998, 1997, and 1996 was as follows:

<TABLE>
<CAPTION>
                                                            WEIGHTED
                                                             AVERAGE
                                                            EXERCISE
                                              SHARES          PRICE
         ------------------------------------------------------------
         <S>                                 <C>            <C>
         Options outstanding at 1/1/96        219,219        $ 0.91
                  Granted                     451,652          1.21
                  Canceled                     (3,103)         0.91
         ------------------------------------------------------------
         Options outstanding at 12/31/96      667,768          1.12
                  Granted                     512,408          8.37
                  Canceled                   (218,869)         1.93
                  Exercised                   (47,325)         0.91
         ------------------------------------------------------------
         Options outstanding at 12/31/97      913,982          5.00
                  Granted                     361,520         23.01
                  Canceled                    (90,486)        16.33
                  Exercised                   (69,783)         1.77
         ------------------------------------------------------------
         Options outstanding at 12/31/98    1,115,233        $10.06
         ------------------------------------------------------------
</TABLE>

The weighted average fair value of the options granted in 1998, 1997, and 1996
was estimated as $15.35, $5.37, and $0.89, respectively, on the date of grant
using the Black-Scholes option-pricing model with the following assumptions:
expected dividend yield: zero; risk-free interest rate: 5.0% in 1998 and a range
from 5.6% to 7.69% in 1997; expected volatility: 63.5% for grants made during
1998, 58.3% for grants made between August 22 and December 31, 1997 and zero for
grants made prior to August 22, 1997; and an expected holding period of seven
years. A summary of options outstanding and exercisable at December 31, 1998 is
as follows:

OPTIONS OUTSTANDING
<TABLE>
<CAPTION>
                                   WEIGHTED
                                  OUTSTANDING        AVERAGE          WEIGHTED
            RANGE OF                  AT            REMAINING         AVERAGE
            EXERCISE             DECEMBER 31,      CONTRACTUAL        EXERCISE
              PRICE                  1998             LIFE             PRICE
         ---------------------------------------------------------------------
         <S>                     <C>               <C>                <C>
          $0.91 - $2.01             585,583            7.4            $ 1.47
          $9.50 - $9.50               8,600            8.8              9.50
         $14.00 - $15.31            230,080            8.6             14.38
         $15.75 - $20.00              7,500            9.1             19.67
         $22.25 - $31.00            283,470            9.4             24.25
</TABLE>

44.
<PAGE>   19


OPTIONS EXERCISABLE

<TABLE>
<CAPTION>
         RANGE OF          OPTIONS EXERCISABLE       WEIGHTED-AVERAGE
         EXERCISE PRICE    AT DECEMBER 31, 1998      EXERCISE PRICE
         ------------------------------------------------------------
         <S>               <C>                       <C>
          $0.91 -  $2.01         242,649                 $ 1.11

          $9.50 -  $9.50           1,720                   9.50

         $14.00 - $15.31          35,260                  14.16

         $15.75 - $20.00              40                  16.50

         $22.25 - $31.00          10,000                  22.73
</TABLE>

At December 31, 1997, options to purchase 279,022 shares were exercisable at a
weighted-average exercise price of $1.06 and with a weighted-average life of
eight years.

Had the Company adopted SFAS No. 123, "Accounting for Stock-Based Compensation,"
for expense recognition purposes, the amount of compensation expense that would
have been recognized in 1998, 1997, and 1996 would have been $1,097,650,
$271,092 and $41,295, respectively. The Company's pro forma net income and pro
forma net income per diluted share for 1998, 1997, and 1996 would have been
reduced to the amounts below:

<TABLE>
<CAPTION>
                                           1998             1997           1996
         --------------------------------------------------------------------------
         <S>                            <C>              <C>              <C>
         Pro forma net income
                  As reported           $7,165,069       $1,913,946       $680,614
                  Pro forma              6,434,130        1,751,291        655,837
         Pro forma net income
            per diluted share
                  As reported                 0.70             0.33           0.17
                  Pro forma                   0.63             0.30           0.16
</TABLE>


PROTECTIVE COMPENSATION AND BENEFIT AGREEMENTS

The Company has entered into Protective Compensation and Benefit Agreements with
certain associates, including all Executive Officers of the Company. These
Agreements, subject to annual review by the Company's Board of Directors, expire
on December 31, 1999, and will be automatically extended in one year increments
unless canceled by the Company. These Agreements provide for specified benefits
in the event of a change in control, as defined in the Agreements. At December
31, 1998, the maximum amount which could be required to be paid under these
Agreements, if such events occur, is approximately $7,906,000.


8. LEASES:

The Company leases facilities, office equipment and computers under agreements
which are classified as capital and operating leases. The leases have initial
terms which range from two to seven years, with eight facility leases that have
provisions to extend the leases for an additional three to five years. Future
minimum payments, by year and in the aggregate, under non-cancelable capital and
operating leases with initial or remaining terms of one year or more, are as
follows at December 31, 1998:

<TABLE>
<CAPTION>
                                               CAPITAL           OPERATING
                                                LEASES             LEASES
         -----------------------------------------------------------------
         <S>                                 <C>              <C>
         1999                                $1,056,265        $ 3,740,287
         2000                                   865,220          3,622,186
         2001                                   604,923          2,859,446
         2002                                   167,013          1,917,634
         2003                                    31,215          1,428,019
         thereafter                               1,784          2,329,676
         -----------------------------------------------------------------
         Total minimum lease payments         2,726,420        $15,897,248
         Amounts representing interest         (303,467)
         -----------------------------------------------------------------
         Present value of net minimum
            lease payments                    2,422,953
         Current portion                       (910,273)
         -----------------------------------------------------------------
         Obligations under capital leases,
            less current portion             $1,512,680
</TABLE>

Rental expense under operating leases for 1998, 1997, and 1996 was $3,150,404,
$1,763,857 and $502,628, respectively.


9. MAJOR CUSTOMERS:

Net revenues from G.D. Searle and Co. accounted for approximately 38%, 54%, and
48% of net revenues in 1998, 1997, and 1996, respectively.

The CRO industry in general continues to be dependent on the research and
development efforts of the principal pharmaceutical and biotechnology companies
as major customers, and the Company believes this dependence will continue. The
loss of business from any of the Company's major customers would have a material
adverse effect on the Company.

                                                                             45.

<PAGE>   20


10. INCOME TAXES:

The provision for income taxes for the year ended December 31, 1998 and 1997, is
as follows:

<TABLE>
<CAPTION>
                                                      1998             1997
         ---------------------------------------------------------------------
         <S>                                      <C>               <C>       
         Current:
         Federal, state and local                 $4,485,737        $  861,095
         Foreign                                    (655,265)          344,624
         ---------------------------------------------------------------------
                  Subtotal                         3,830,472         1,205,719

         Deferred:
         Federal and state                           825,991            91,328
         Effect of termination of S corporation
            status                                                     144,572
         Foreign                                    (107,420)            9,565
         ---------------------------------------------------------------------
                  Subtotal                           718,571           245,465

         Benefit applied to reduce goodwill          344,074
         ---------------------------------------------------------------------
         Total provision                          $4,893,117        $1,451,184
</TABLE>

The Company's consolidated effective income tax rate differed from the U.S.
federal statutory income tax rate of 35% and 34% in 1998 and 1997, respectively
as set forth below:

<TABLE>
<CAPTION>
                                                         1998          1997
         ---------------------------------------------------------------------
         <S>                                             <C>           <C>
         Income tax expense at the U.S. federal          
            statutory rate                               35.0%         34.0%
                                                         
         S corporation income for which no               
            current income taxes were provided                        (14.4)
                                                         
         Effects of foreign taxes                         2.4           3.2
                                                         
         State and local income taxes, net of            
            federal benefit                               5.3           1.6
                                                         
         Effect of termination of S corporation status                  2.8
                                                         
         Other                                           (2.1)          1.2
         ---------------------------------------------------------------------
         Total                                           40.6%         28.4%
</TABLE>

A provision has not been made for U.S. or additional foreign taxes on the
undistributed portion of earnings of foreign subsidiaries as those earnings have
been permanently reinvested. It is not practicable to determine the amount of
applicable taxes that would be due were such earnings distributed.

Components of the Company's net deferred tax asset and liability included in the
consolidated balance sheet at December 31, 1998 and 1997 are as follows:

<TABLE>
<CAPTION>
                                                         1998          1997
         ---------------------------------------------------------------------
         <S>                                           <C>           <C>
         Deferred tax assets:
         Compensation and employee benefits            $116,169      $113,966
         Accrued expenses and other future
            deductible items                            198,517        70,700
         Operating loss carryforward                    152,150
         Other                                           70,068
         ---------------------------------------------------------------------
         Total deferred tax assets                      536,904       184,666
         ---------------------------------------------------------------------
         Deferred tax liabilities:
         Software costs                                 953,857       217,054
         Depreciation                                   154,191       135,940
         Intangible assets                              306,198        22,318
         Other                                           60,944
         ---------------------------------------------------------------------
         Total deferred tax liability                 1,475,190       375,312
         ---------------------------------------------------------------------
         Total net deferred tax liability              $938,286      $190,646
         ---------------------------------------------------------------------
</TABLE>

The operating loss carryforward of approximately $480,000 can be carried forward
indefinitely.


11. SHAREHOLDERS' EQUITY:

In June, 1998, the Company completed its follow-on offering of 2,415,000 shares
of common stock at a price to the public of $23.50 per share. Of the 2,415,000
shares sold, 2,315,000 were sold by the Company and 100,000 shares were sold by
selling shareholders. Proceeds to the Company approximated $51.4 million, net of
underwriting commissions and discounts and offering expenses of $3.0 million.

In August, 1997, the Company and its shareholders completed an initial public
offering ("IPO") of 4,140,000 shares of common stock at a price to the public of
$14.00 per share. Of the 4,140,000 shares sold, 3,540,000 were sold by the
Company and 600,000 shares were sold by selling shareholders. Proceeds to the
Company approximated $45.2 million, net of underwriting commissions and
discounts and offering expenses of $4.4 million.


46.
<PAGE>   21


12. ACQUISITIONS:

In February, 1998, the Company completed its acquisition of ACER/EXCEL Inc.
("ACER/EXCEL"), headquartered in Cranford, New Jersey. Total acquisition costs
consisted of $14.4 million in cash and 987,574 shares of the Company's Common
Stock. The value of the stock consideration was determined for financial
reporting purposes as of December 23, 1997, the date the purchase price was
agreed to. Valuation of the Common Stock was based on an appraisal obtained by
the Company which discounted the shares due to lock-up restrictions and the lack
of registration of the shares.

A general escrow, which was established at the acquisition date to provide
indemnification of sellers' representations and warranties and currently
consists of 186,336 shares of the Company's Common Stock, was scheduled to be
released to the sellers, 50% in February, 1999 and the remainder in February,
2000. The February, 1999 scheduled release of the escrow is pending resolution
of ongoing discussions between the parties. 

In September, 1997, the Company acquired GMI Gesellschaft fur Angewandte
Mathematik und Informatik mbH ("gmi"). Acquisition costs of $12.7 million
consisted of $10.0 million in cash and the issuance of 191,304 shares of the
Company's Common Stock, valued at $14 per share or $2.7 million.

The Company acquired U-Gene Research B.V. ("U-Gene") in June, 1997 for
approximately $15.9 million in cash. Approximately $1.6 million of the purchase
price was payable to the U-Gene shareholders and was deposited in an escrow
account pursuant to the U-Gene Purchase Agreement. In January, 1999,
approximately $700,000 held in escrow was paid to the U-Gene shareholders. The
remaining $900,000 of the promissory note has not been released and is pending
resolution of ongoing discussions between the parties.

The following unaudited pro forma results of operations assume the acquisitions
of U-Gene, gmi and ACER/EXCEL occurred at the beginning of 1997:

<TABLE>
<CAPTION>
                                                         1998          1997
         -----------------------------------------------------------------------
         <S>                                         <C>             <C>
         Net revenues                                $90,779,761     $67,484,265
         Income before extraordinary item              7,052,478       6,319,541
         Net income                                    7,052,478       5,179,718
         Income before extraordinary item
            (assuming the Company was taxed as 
            a C corporation throughout 1997)           7,052,478       4,641,016
         Net income per diluted share                       0.67            0.75
         Income per diluted share before
            extraordinary item (assuming the 
            Company was taxed as a C corporation 
            throughout 1997)                                0.67            0.67
         Weighted average shares                      10,463,864       6,879,816
         -----------------------------------------------------------------------
</TABLE>

The pro forma financial information is not necessarily indicative of the
operating results that would have occurred had the acquisitions been consummated
at January 1, 1997 and 1998, nor are they necessarily indicative of future
operating results.


13. RELATED PARTY TRANSACTION:

The Company made payments in 1998, 1997, and 1996 totaling approximately
$426,000, $397,000, and $97,500, respectively, to a construction company owned
by a relative of the Company's primary shareholder, for construction and
renovations at various Company locations.


14. EXTRAORDINARY ITEM:

In 1997, the Company recorded an extraordinary item for the early extinguishment
of indebtedness of $1.1 million, net of tax benefits of approximately $426,000.
The extraordinary item resulted from the write-off of the debt discount recorded
in connection with long-term borrowings. Such borrowings were made by the
Company in connection with the acquisition of U-Gene prior to the Company's IPO
and were repaid with the proceeds of the IPO.


                                                                             47.
<PAGE>   22


15. SUBSEQUENT EVENT:

In January, 1999, the Company acquired Research Consultants (International)
Holdings Ltd. ("IRC"), a U.K.-based company. Total acquisition costs consisted
of approximately $4.1 million in cash and 87,558 shares of the Company's Common
Stock. The shares have been placed in an escrow account pursuant to the IRC
Share Purchase Agreement, 50% to be released in January, 2000 and the remainder
in 2001. This acquisition will be accounted for using the purchase method of
accounting.

Additionally, in January, 1999, the Company acquired a minority interest in
Component Software International, Inc. ("CSI"), a software consulting and
development company, for approximately $1.6 million in cash and 19,995 shares of
the Company's Common Stock. Concurrent with this transaction, the Company
entered into a Multi-Year Strategic Service Agreement with CSI whereby the
Company will pay CSI $7.0 million over the next four years in exchange for
strategic software consulting and development services from CSI.


16. SEGMENT INFORMATION:

The Company does not manage nor is it organized into separate operating
segments. The Company manages its business in the aggregate, as a full-service
international CRO. Principal financial information by geographic areas is as
follows:

<TABLE>
<CAPTION>
                                                1998                1997
         -----------------------------------------------------------------------
         <S>                                <C>                <C>
         Net Revenues                                          
                                                               
                  North America            $ 67,167,833        $ 33,850,189
                  Foreign                    22,348,305          10,382,710
         -----------------------------------------------------------------------
                                           $ 89,516,138        $ 44,232,899
                                                               
         Identifiable Assets                                   
                                                               
                  North America            $113,125,603        $ 40,893,382
                  Foreign                    40,114,279          38,731,226
         -----------------------------------------------------------------------
                                           $153,239,882        $ 79,624,608
</TABLE>

Net revenues of the Company's wholly-owned subsidiaries have been included in
the consolidated statements of income from the respective dates of acquisition.


48.
<PAGE>   23


REPORT OF INDEPENDENT ACCOUNTANTS




To the Board of Directors and Shareholders

Kendle International Inc.

In our opinion, the accompanying consolidated balance sheets and the related
consolidated statements of income, shareholders' equity and cash flows present
fairly, in all material respects, the financial position of Kendle International
Inc. and its subsidiaries (the "Company") at December 31, 1998 and 1997, and the
results of their operations and their cash flows for each of the three years in
the period ended December 31, 1998, in conformity with generally accepted
accounting principles. These financial statements are the responsibility of the
Company's management; our responsibility is to express an opinion on these
financial statements based on our audits. We conducted our audits of these
statements in accordance with generally accepted auditing standards which
require that we plan and perform the audit to obtain reasonable assurance about
whether the financial statements are free of material misstatement. An audit
includes examining, on a test basis, evidence supporting the amounts and
disclosures in the financial statements, assessing the accounting principles
used and significant estimates made by management, and evaluating the overall
financial statement presentation. We believe that our audits provide a
reasonable basis for the opinion expressed above.



/s/PricewaterhouseCoopers LLP

February 15, 1999
Cincinnati, Ohio




                                                                             49.
<PAGE>   24


MANAGEMENT TEAM


<TABLE>
<CAPTION>
<S>                                          <C>                                          <C>
EXECUTIVE OFFICERS                           Brenda J. Hoeper                             Dennis C. Glaser
Candace Kendle, PharmD                       Director, Clinical Data                      Director, Global Proposals
Chairman & CEO                               Management
                                                                                          Mary W. Kuramoto
Christopher C. Bergen                        Maro L. Hoffman, MD                          Director, Corporate Communications
President & COO                              Senior Director, Global Safety
                                                                                          Michael E. Laird
Timothy M. Mooney                            Ronald P. Koning, MD                         Director, Strategic Account
Executive Vice President & CFO               Managing Director, Utrecht                   Development North America

CLINICAL OPERATIONS                          John H. Lasley                               James C. Linde
Bruce Kreter, PharmD                         Managing Director, Cincinnati                Director, Target Excellence
Vice President, Clinical Development
                                             Kathleen A. Lukacs                           Joseph D. Loudon
Nigel G. Page                                Managing Director, Cranford                  Director, Integration
Vice President, European       
Operations                                   Inge M. Neiss                                Rafael J. Manoera
                                             Co-Managing Director, Munich                 Director, Mergers & Acquisitions
Frank L. Santoro, MD
Vice President, North American               Susan E. Oakley                              Michael G. Minor
Operations                                   Director, Clinical Operations                Vice President, Strategic Accounts
                                             Europe
Michael F. Bayer                                                                          Douglas G. Moehring
Managing Director, Chicago and               Lois B. Rosenberger, PhD                     Senior Director, Client Services
Los Angeles                                  Vice President, Regulatory
                                             Affairs/Quality Assurance                    Ann Nightingale
Janet L. Brennan                                                                          Director, Strategic Accounts
Director, Project Management                 William K. Stetsema, PhD
                                             Director, Clinical Research                  Paul F. Ritter, Esq.
Dagmar M. Chase, PhD                                                                      Senior Director & General Counsel
Co-Managing Director, Munich                 Mandyam K. Srirama, PhD
                                             Senior Director, Biostatistics               Stephen G. Scheurer
Philip J.W. Davies                                                                        Senior Director, Human Resources
Director, Clinical Pharmacology Unit         Carl R. Torchio
                                             Managing Director, Princeton                 Kevin M. Schwarz
Peter E. Djuric, PharmD                                                                   Senior Director & Corporate
Director, Post Marketing                     ADMINISTRATION                               Controller
Surveillance                                 Thomas E. Stilgenbauer
                                             Senior Vice President,                       Dieter Seitz-Tutter, PhD
Philip E. Doren, PhD                         Organizational Development                   Senior Director, Strategic Account
Director, Clinical Monitoring                                                             Development Europe
North America                                Gary M. Wedig
                                             Vice President & CIO                         Amy B. Shannon
John Glasby, PhD                                                                          Director, Corporate Training &
Co-Director, Regulatory Affairs              Kevin L. Brandenburg                         Development
Europe                                       Director, Facilities
                                                                                          Cathy J. Thompson
Gillian Gregory                              Anthony L. Forcellini                        Director, Strategic Accounts
Co-Director, Regulatory Affairs              Executive Director, Mergers &
Europe                                       Acquisitions

Jere M. Hardy                                Jeffrey A. Glancy
Vice President, Clinical Data                Director, Taxation
Management
</TABLE>

50.
<PAGE>   25


CORPORATE INFORMATION

<TABLE>
<CAPTION>
<S>                                          <C>                                          <C>
BOARD OF DIRECTORS AND                       STOCK INFORMATION                            ANNUAL MEETING
EXECUTIVE OFFICERS*
                                             The Common Stock of Kendle                   The 1999 Annual Meeting of
Candace Kendle*                              International Inc. trades on The             Shareholders will be held at 10:00
Chairman of the Board & CEO                  Nasdaq Stock Market(R) under the             a.m. on Thursday, May 20, 1999 at
                                             symbol KNDL. The Common Stock                the Media Center, RiverCenter
Christopher C. Bergen*                       was initially offered to the public          Tower Offices, 50 East RiverCenter
President & COO                              on August 22, 1997 at a price of             Boulevard, Covington, Kentucky,
Director                                     $14.00 per share and commenced               41011
                                             trading on that date.
Timothy M. Mooney*                                                                        TRANSFER AGENT AND REGISTRATION
Executive Vice President & CFO               At March 10, 1999, there were
Director                                     approximately 2,789 beneficial               Fifth Third Bank
                                             shareholders. The Company has                Shareholder Services
Philip E. Beekman                            not paid dividends on its Common             Mail Drop 1090FS
Director                                     Stock since inception.                       38 Fountain Square Plaza
Former Chairman of the Board &                                                            Cincinnati, Ohio 45263
CEO, Hook-SupeRx, Inc.                       FINANCIAL REPORTS
                                                                                          INDEPENDENT ACCOUNTANTS
Robert Buck                                  Copies of the Company's Annual
Director                                     Report on Form 10-K and                      PricewaterhouseCoopers LLP
President, Uniform Rental Division           Quarterly Reports on Form 10-Q               Cincinnati, Ohio
Cintas Corporation                           filed with the Securities and
                                             Exchange Commission, as well as              OUTSIDE LEGAL COUNSEL
Mary Beth Price                              other investor materials, are avail-
Director                                     able upon request from:                      Keating, Muething & Klekamp, P.L.I.
Founder, Empower MediaMarketing                                                           Cincinnati, Ohio
Professor, Richard A. Forsythe               Julie G. Lerner
Chair in Entrepreneurship at the             Investor Relations
Richard T. Farmer School of                  Kendle International Inc.
Business, Miami University                   700 Carew Tower
                                             441 Vine Street
Charles A. Sanders, MD                       Cincinnati, Ohio 45202
Director
Former Chairman of the Board &               or access these reports electroni-
CEO, Glaxo, Inc.                             cally on the Internet. Kendle's
                                             web site address is:
                                             http://www.kendle.com
</TABLE>

<PAGE>   1
                                                                    Exhibit 23.1

                       CONSENT OF INDEPENDENT ACCOUNTANTS

We consent to the incorporation by reference in the registration statement of
Kendle International Inc. on Form S-8 (File Nos. 333-57577 and 333-34261) of our
report dated February 15, 1999, on our audits of the consolidated financial
statements of Kendle International Inc. as of December 31, 1998 and 1997, and
for the years ended December 31, 1998, 1997, and 1996, which report is included
in this Annual Report on Form 10-K.


/s/PricewaterhouseCoopers LLP


Cincinnati, Ohio
March 29, 1999

<TABLE> <S> <C>

<ARTICLE> 5
<MULTIPLIER> 1,000
<CURRENCY> U.S.DOLLARS
       
<S>                             <C>
<PERIOD-TYPE>                   YEAR
<FISCAL-YEAR-END>                          DEC-31-1998
<PERIOD-START>                             JAN-01-1998
<PERIOD-END>                               DEC-31-1998
<EXCHANGE-RATE>                                      1
<CASH>                                          13,980
<SECURITIES>                                    40,768
<RECEIVABLES>                                   28,518
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                                91,390
<PP&E>                                          16,359
<DEPRECIATION>                                 (5,039)
<TOTAL-ASSETS>                                 153,240
<CURRENT-LIABILITIES>                           25,894
<BONDS>                                              0
                                0
                                          0
<COMMON>                                            75
<OTHER-SE>                                     122,425
<TOTAL-LIABILITY-AND-EQUITY>                   153,240
<SALES>                                         89,516
<TOTAL-REVENUES>                                89,516
<CGS>                                           46,607
<TOTAL-COSTS>                                   78,748
<OTHER-EXPENSES>                               (1,575)
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                 284
<INCOME-PRETAX>                                 12,058
<INCOME-TAX>                                     4,893
<INCOME-CONTINUING>                              7,165
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                     7,165
<EPS-PRIMARY>                                      .75
<EPS-DILUTED>                                      .70
        

</TABLE>


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