<PAGE>
As filed with the Securities and Exchange Commission on December 22, 1997
Registration No. 333-31281
================================================================================
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
____________________
POST-EFFECTIVE AMENDMENT NO. 1
TO
FORM S-1
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
___________________
CRESCENDO PHARMACEUTICALS CORPORATION
(Exact name of registrant on Form S-1 as specified in its charter)
DELAWARE 8521214 77-0460388
(State or other (Primary Standard Industrial (I.R.S. Employer
jurisdiction of Classification Code Number) Identification No.)
Incorporation or
organization)
1454 PAGE MILL ROAD
PALO ALTO, CALIFORNIA 94304
(650) 494-5600
(Address, including zip code, and telephone number, including area code, of
registrant's principal executive offices)
___________________
GARY L. NEIL, PH.D.
President and Chief Executive Officer
CRESCENDO PHARMACEUTICALS CORPORATION
1454 PAGE MILL ROAD
PALO ALTO, CALIFORNIA 94304
(650) 494-5600
(Name, address, including zip code, and telephone number, including area code,
of agent for service)
___________________
COPY TO:
SARAH A. O'DOWD, ESQ.
HELLER EHRMAN WHITE & MCAULIFFE
525 UNIVERSITY AVENUE
PALO ALTO, CALIFORNIA 94301
TELEPHONE: (650) 324-7000
FACSIMILE: (650) 324-0638
================================================================================
<PAGE>
On September 30, 1997, the Registrant issued to ALZA Corporation
("ALZA"), and ALZA distributed to its stockholders and debenture holders,
4,965,470 shares of common stock of the Registrant pursuant to this Registration
Statement. The Registrant hereby withdraws from registration 834,530 shares of
its common stock that were covered by this Registration Statement, but not
issued in the distribution. The Registration Statement is hereby amended, as
appropriate, to reflect the distribution of 4,965,470 shares.
<PAGE>
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, Crescendo
Pharmaceuticals Corporation has duly caused this Post-Effective Amendment No. 1
to the Registration Statement on Form S-1 to be signed on its behalf by the
undersigned, thereunto duly authorized, in the City of Palo Alto, State of
California on December 22, 1997.
Crescendo Pharmaceuticals Corporation
By: /s/ Gary L. Neil
-------------------------------------
GARY L. NEIL, PH.D., DIRECTOR,
PRESIDENT AND CHIEF EXECUTIVE OFFICER
Pursuant to the requirements of the Securities Act of 1933, this Post-
Effective Amendment No. 1 to the Registration Statement on Form S-1 has been
signed by the following persons in the capacities and on the dates indicated
<TABLE>
<CAPTION>
SIGNATURE CAPACITY DATE
--------- -------- -----
<S> <C> <C>
/s/ Gary L. Neil Director, President and Chief Executive December 22, 1997
- ----------------------------------------- Officer (Principal Executive Officer)
GARY L. NEIL, PH.D.
/s/ Terrence F. Blaschke Director December 22, 1997
- -----------------------------------------
TERRENCE F. BLASCHKE, M.D.
Director
- -----------------------------------------
JERRY T. JACKSON
/s/ M. David MacFarlane Director December 22, 1997
- -----------------------------------------
M. DAVID MACFARLANE, PH.D.
/s/ Gerald J. Papariello Director December 22, 1997
- -----------------------------------------
GERALD J. PAPARIELLO, PH.D.
/s/ Ley S. Smith Director December 22, 1997
- -----------------------------------------
LEY S. SMITH
/s/ David R. Hoffmann Vice President, Finance (Principal December 22, 1997
- ----------------------------------------- Financial and Accounting Officer)
DAVID R. HOFFMANN
</TABLE>
