CRESCENDO PHARMACEUTICALS CORP
10-Q, 1998-08-13
PHARMACEUTICAL PREPARATIONS
Previous: CAPSTAR BROADCASTING CORP, 10-Q, 1998-08-13
Next: LJL BIOSYSTEMS INC, S-8, 1998-08-13









                                  
                           UNITED STATES
                 SECURITIES AND EXCHANGE COMMISSION
                       Washington, D.C. 20549

                             FORM 10-Q



 ( X )     Quarterly  Report Pursuant to Section 13 or 15(d)  of  the
     Securities  Exchange Act of 1934 for the quarterly period  ended
     June 30, 1998

                                 or

 (   )       Transition Report Pursuant to Section 13 or 15(d) of the
     Securities Exchange Act of 1934 for the transition period from
     __________ to __________

                   Commission File Number 0-22927

               CRESCENDO PHARMACEUTICALS CORPORATION
       (Exact name of registrant as specified in its charter)

               Delaware                                77-0460388
 (State or other jurisdiction of                 (I.R.S. Employer
  incorporation or organization)              Identification No.)

1454 Page Mill Road, Palo Alto, California                  94304
(Address of principal executive offices)               (Zip Code)


Registrant's telephone number, including area code (650) 494-5600


      Indicate by check mark whether the registrant (1) has filed all
reports required to be filed by Section 13 or 15(d) of the Securities
Exchange  Act  of 1934 during the preceding 12 months  (or  for  such
shorter  period  that  the  registrant  was  required  to  file  such
reports),  and  (2) has been subject to such filing requirements  for
the past 90 days.

                         Yes _X__  No


Number  of shares outstanding of each of the registrant's classes  of
common stock as of July 31, 1998:

Class A Common Stock, $.01 par value - 4,965,470 shares

Class B Common Stock, $1.00 par value - 1,000 shares



                CRESCENDO PHARMACEUTICALS CORPORATION
                   FORM 10-Q for the Quarter Ended
                            June 30, 1998
                                  
                                  
                                INDEX


Part I. Financial Information


Item 1. Financial Statements

     Statement of Operations                                          3
     Balance Sheet                                                    4
     Statement of Cash Flows                                          5
     Notes to Financial Statements                                 6-12

Item 2. Management's Discussion and Analysis of
      Financial Condition and Results of Operations               13-15

Item 3. Quantitative and Qualitative Disclosures
      about Market Risk                                              15

Part II. Other Information

Item 4. Submission of Matters to a Vote of                           16
      Security Holders


Item 6. Exhibits and Reports on Form 8-K                              16


Signatures                                                            17


Exhibits

PART I.   FINANCIAL INFORMATION

Item 1.   Financial Statements

                Crescendo Pharmaceuticals Corporation
                    (a development stage company)
                                  
                 Statement of Operations (unaudited)
              (in thousands, except per share amounts)


                        Three months    Six months   Period from inception
                            ended          ended          (June 26, 1997)
                           June 30,       June 30,         to June 30,
                            1998            1998               1998

_____________________________________________________________________

Revenues:
  Net interest and
   investment income     $  3,364       $   7,202       $     11,285


Expenses:
  Research & development
   performed under
   contract with ALZA
   Corporation             28,606          50,031            82,310
  General & administrative    378             673               918
_____________________________________________________________________
   Total expenses          28,984          50,704            83,228
_____________________________________________________________________

Net loss                 $(25,620)    $   (43,502)        $ (71,943)
=====================================================================

Net loss per common share

  Basic                  $   (5.16)   $     (8.76)     $  (19.24)
======================================================================

  Diluted                $   (5.16)   $     (8.76)     $  (19.24)
======================================================================




See accompanying notes.

                Crescendo Pharmaceuticals Corporation
                    (a development stage company)
                                  
                      Balance Sheet (unaudited)
    (in thousands, except number of shares and per share amounts)


                                          June 30,  December 31,
                                            1998         1997
_________________________________________________________________________
ASSETS

Current assets:
   Cash and cash equivalents            $  59,188      $179,971
   Short-term investments                  68,528        29,601
   Interest receivable                      2,349           967
   Prepaid expenses and other
    current assets                            310           110
_____________________________________________________________________

      Total current assets                 130,375       210,649

Employee loan                                  300           300
Long-term investments                      113,749        75,638
______________________________________________________________________

      Total assets                       $ 244,424      $286,587
======================================================================

LIABILITIES AND STOCKHOLDERS' EQUITY

Current liabilities:
   Payable to ALZA Corporation          $  16,064      $ 15,068
   Accrued liabilities                        107            40
_____________________________________________________________________


      Total current liabilities             16,171        15,108

Stockholders' equity:
   Class A Common Stock, $0.01 par value,
    6,000,000 shares authorized; 4,965,470
    issued and outstanding                      50            50
   Class B Common Stock, $1.00 par value,
    1,000 shares authorized, issued and
    outstanding                                  1             1
   Additional paid-in capital              299,949       299,949
   Accumulated other comprehensive income
    (loss)                                     196          (80)
   Deficit accumulated during development
    stage                                 (71,943)      (28,441)
_____________________________________________________________________
      Total stockholders' equity           228,253       271,479
_____________________________________________________________________
       Total liabilities and
        stockholders' equity            $ 244,424      $286,587
======================================================================

See accompanying notes.

              Crescendo Pharmaceuticals Corporation
                  (a development stage company)
                                
               Statement of Cash Flows (unaudited)
       Increases (Decreases) in Cash and Cash Equivalents
                         (in thousands)
                                                      Period
                                                  from inception
                                Six months ended  (June 26, 1997)
                                  June 30, 1998     to June 30,
                                                        1998
__________________________________________________________________________
CASH FLOWS FROM OPERATING ACTIVITIES:
  Net loss                     $       (43,502)       $(71,943)
  Non-cash adjustments to reconcile
     net loss to net cash used in
     operating activities:

     Increase in assets:
       Interest receivable             (1,382)         (2,349)
       Prepaid expenses and other
          assets                         (200)           (310)

     Increase in liabilities:
        Payable to ALZA Corporation        996          16,064
        Accrued liabilities                 67             107
__________________________________________________________________________

     Total adjustments                   (519)          13,512

Net cash used in operating activities (44,021)        (58,431)

CASH FLOWS FROM INVESTING ACTIVITIES:
  Purchases of available-for-sale
     securities                      (101,299)       (206,618)
  Sales of available-for-sale
     securities                         24,537          24,537
  Employee loan, long-term                   -           (300)
__________________________________________________________________________

Net cash used in investing activities (76,762)       (182,381)

CASH FLOWS FROM FINANCING ACTIVITIES:
  Issuance of common stock to
     ALZA Corporation                        -         300,000
__________________________________________________________________________
Net cash provided by financing
  activities                                 -         300,000
__________________________________________________________________________
Net increase (decrease) in cash and
  cash equivalents                   (120,783)          59,188
__________________________________________________________________________
Cash and cash equivalents
  at beginning of period               179,971               -
__________________________________________________________________________

Cash and cash equivalents
  at end of period                  $   59,188          $  59,188
=========================================================================

See accompanying notes.

Crescendo Pharmaceuticals Corporation
(a development stage company)

Notes to Financial Statements (unaudited)

Note 1. Basis of Presentation and Significant Accounting Policies

   Crescendo Pharmaceuticals Corporation ("Crescendo") was
incorporated in Delaware on June 26, 1997 and commenced
operations on September 30, 1997.  Crescendo was formed for the
purpose of selecting and developing human pharmaceutical products
and commercializing such products, most likely through licensing
to ALZA Corporation ("ALZA"). Since its formation, Crescendo's
principal activities have been conducting product development
under its agreements with ALZA.  In accordance with generally
accepted accounting principles, Crescendo is considered a
development stage company.

   The information at June 30, 1998, for the three and six months
ended June 30, 1998 and for the period from inception through
June 30, 1998 is unaudited, and includes all adjustments
(consisting only of normal recurring adjustments) that the
management of Crescendo believes necessary for fair presentation
of the results for the periods presented.  Interim results are
not necessarily indicative of the results for the full year.  The
balance sheet for December 31, 1997 was derived from the audited
balance sheet.  The financial statements should be read in
conjunction with the audited financial statements and
accompanying notes for the year ended December 31, 1997 included
in Crescendo's 1997 Annual Report on Form 10-K.

Accounting for Revenues and Expenses

   Crescendo's revenue currently consists solely of interest and
investment income.  If and when any products of Crescendo are
commercialized, Crescendo will also derive revenue from the sale
or license of such products, most likely through the sale of
licensed products by third parties.  Royalty and other product
revenue will be recorded as earned.

   Crescendo expects to incur most of its expenses under its
agreements with ALZA.  Development costs paid to ALZA under a
Development Agreement, and a Technology Fee (defined below) paid
to ALZA under a Technology License Agreement, are recorded as
research and development expenses when incurred.  Amounts paid to
ALZA under a Services Agreement are recorded as administrative
expenses when incurred.  See Note 4 for a description of the
agreements between Crescendo and ALZA.

Use of Estimates

    The preparation of financial statements in accordance with
generally accepted accounting principles requires management to
make estimates and assumptions that affect the amounts reported
in the financial statements and accompanying notes.  Actual
results could differ from those estimates.

Cash, Cash Equivalents and Short-Term Investments

     Cash and cash equivalents include cash balances and
investments with maturities of three months or less at the time
of purchase.  Short-term investments include commercial paper and
other highly liquid investments with maturities less than one
year.  The carrying amount reported on the balance sheet for
cash, cash equivalents and short-term investments approximates
their fair value.

Recently Issued Accounting Pronouncement

     In June 1997, the Financial Accounting Standards Board
issued Statement of Financial Accounting Standards  No. 131
"Disclosures about Segments of an Enterprise and Related
Information" ("SFAS 131"). SFAS 131 establishes standards for
annual and interim disclosures of operating segments, products
and services, geographic areas and major customers, and is
effective in 1998.  The adoption of SFAS 131 will have no impact
on Crescendo's results of operations or financial condition.

Comprehensive Income (Loss)

     As of January 1, 1998, Crescendo adopted Statement of
Financial Accounting Standards No 130, "Reporting Comprehensive
Income" ("SFAS 130") which establishes standards for reporting
comprehensive income and its components.  Comprehensive loss
includes net loss plus other comprehensive loss.  For Crescendo,
other comprehensive loss primarily comprises net unrealized gains
or losses on available-for-sale securities.  Total comprehensive
loss was $25.4 million, $43.2 million and $71.7 million for the
quarter ended June 30, 1998, the six months ended June 30, 1998
and the period from inception through June 30, 1998,
respectively.  The adoption of SFAS 130 had no impact on
Crescendo's results of operations or financial condition.

Note 2. Investments

     Crescendo has classified its entire investment portfolio,
including cash and cash equivalents of approximately $59.2
million at June 30, 1998, as available-for-sale.  Investments in
the available-for-sale category are carried at fair market value
with unrealized gains and losses recorded as a separate component
of stockholders' equity.  Realized gains and losses for the
period ended June 30, 1998 were not material.  The cost of
securities when sold is based upon specific identification.


     The following is a summary of available-for-sale securities
at June 30, 1998 (in thousands):

                          Available-for-Sale Securities
__________________________________________________________________________
                                                       Estimated
                   Amortized   Unrealized  Unrealized    Fair
                      Cost       Gains       Losses     Value
__________________________________________________________________________

U.S. Treasury
 securities and
 obligations of
 U.S. government
 agencies            $ 75,849    $     44   $   (72)    $ 75,821

Collateralized
 mortgage
 obligations and
 asset backed
 securities            32,821          80          -      32,901

Corporate securities
 (commercial paper,
 corporate notes and
 money market funds)  132,509    196         (52)        132,653
__________________________________________________________________________
                     $241,179  $ 320     $  (124)       $241,375
==========================================================================

The amortized cost and estimated fair value of debt and
marketable securities at June 30, 1998, by contractual maturity,
are shown below (in thousands). Expected maturities will differ
from contractual maturities because the issuers of the securities
may have the right to prepay obligations without prepayment
penalties.

                                                 Estimated
                               Amortized           Fair
                                 Cost              Value
__________________________________________________________________________

Due in one year or less        $ 127,598        $  127,626
Due after one year through
 three years                      65,379            65,380
Due after three years through
 five years                       48,202            48,369
__________________________________________________________________________
                               $ 241,179        $  241,375
=========================================================================

Investment Risk

     Crescendo invests excess cash in money market and fixed
income securities of companies with strong credit ratings, from a
variety of industries, and in U.S. government obligations.  These
securities typically bear minimal credit risk and Crescendo has
not experienced any losses on its investments to date due to
credit risk.

Note 3. Per Share Information

     Basic earnings (loss) per share is calculated by dividing
net loss by the weighted average common shares outstanding for
the period. Diluted earnings (loss) per share is calculated by
dividing net loss by the weighted average common shares
outstanding for the period plus the dilutive effect of stock
options, warrants and convertible securities.

     The following table sets forth the computation of
Crescendo's basic and diluted loss per share:
                                                        Period from
                       Three months     Six months        inception
                          ended           ended        (June 26,1997)to
                      June 30, 1998    June 30, 1998    June 30, 1998
____________________________________________________________________________
NUMERATOR (in thousands):
Basic and Diluted
  Net loss            $   (25,620)   $    (43,502)       $   (71,943)
=========================================================================

DENOMINATOR (in thousands):
Basic and Diluted
  Weighted average shares
    outstanding       $     4,966     $     4,966              3,739
=========================================================================
Basic net loss
 per share            $     (5.16)    $    (8.76)      $      (19.24)
=========================================================================
Diluted net loss
 per share            $     (5.16)    $    (8.76)      $      (19.24)

     The potentially dilutive effect of outstanding options to
purchase 100,000 shares of Crescendo Class A Common Stock (the
"Crescendo Shares") would have been anti-dilutive in the three
and six months ended June 30, 1998 and for the period from
inception through June 30, 1998, and they were therefore excluded
from the diluted per share calculations.

Note 4. Arrangements with ALZA Corporation

    On September 29, 1997, ALZA contributed $300 million in cash
to Crescendo.  On September 30, 1997, all of the Crescendo
Shares, a total of 4,965,470, were distributed to the holders of
ALZA common stock and ALZA's convertible subordinated debentures.
Crescendo +Shares are traded on The NASDAQ Stock Market-service
mark- under the symbol "CNDO." ALZA holds 1,000 shares of
Crescendo Class B Common Stock.

    In connection with ALZA's contribution to Crescendo and the
distribution of Crescendo Shares, Crescendo and ALZA entered into
a number of agreements, including a Development Agreement,
Technology License Agreement, License Option Agreement and
Services Agreement, discussed below.

    Crescendo and ALZA have entered into a Development Agreement
pursuant to which ALZA conducts product development and related
activities on behalf of Crescendo under work plans and cost
estimates which have been proposed by ALZA and approved by
Crescendo.  Crescendo is required to utilize the cash initially
contributed to it by ALZA plus interest thereon, less Crescendo's
administrative expenses, the Technology Fee paid to ALZA and
reserves of up to $2 million (the "Available Funds") to conduct
activities under the Development Agreement.

    Under the Development Agreement, Crescendo agreed to fund the
development of seven products (the "Initial Products"), the
development of which was commenced by ALZA and Therapeutic
Discovery Corporation ("TDC"), from August 25, 1997, the date on
which TDC ceased funding such products, through October 31, 1997.
Continuation of development of the Initial Products after October
31, 1997 was subject to ALZA proposing, and Crescendo's Board of
Directors accepting, work plans and cost estimates for the
Initial Products.  As of July 31, 1998, three of the Initial
Products (OROS -registered trademark- oxybutynin, DUROS-trademark-
leuprolide and OROS-registered trademark- methylphenidate) were
in active development.  During the second quarter of 1998, ALZA
completed feasibility evaluations for the E-TRANS-trademark- LHRH
and E-TRANS-trademark- Macroflux-trademark- insulin products.
Based on the results of the evaluations, on ALZA's
recommendation, Crescendo is not funding additional development
of these products at this time.  Research and development
expenses for the three months and six months ended June 30, 1998
were $28.6 million and $50.0 million, respectively, including a
Technology Fee expense of $3.0 million and $6.0 million,
respectively.  For the period from inception through June 30,
1998, Crescendo recorded research and development expenses of
$82.3 million, including a Technology Fee expense of $10.0
million.

   Crescendo and ALZA have entered into a Technology License
Agreement pursuant to which ALZA has granted to Crescendo a
worldwide license to use ALZA technology solely to select and
develop human pharmaceutical products (the "Crescendo Products")
(including the Initial Products), to conduct related activities,
and to commercialize such products.  In exchange for the license
to use existing ALZA technology relating to the Initial Products,
Crescendo pays a Technology Fee to ALZA, monthly over a period of
three years, in the amount of $1 million per month for the first
12 months following the distribution of Crescendo Shares,
$667,000 per month for the following 12 months and $333,000 per
month for the next 12 months (the "Technology Fee").  The
Technology Fee will no longer be payable at such time as fewer
than two of the Initial Products are being developed by Crescendo
and/or have been licensed by ALZA pursuant to the License Option
(defined below).  The Technology Fee is included in research and
development expenses.

    Pursuant to the License Option Agreement entered into by
Crescendo and ALZA, Crescendo has granted ALZA an option to
acquire a license to each Crescendo Product (the "License
Option").  The License Option for any such Crescendo Product is
exercisable on a country-by-country basis at any time until (i)
with respect to the United States, 30 days after clearance by the
FDA to market such Crescendo Product in the United States and
(ii) with respect to any other country, 90 days after the earlier
of (a) clearance by the appropriate regulatory agency to market
the Crescendo Product in such country and (b) clearance by the
FDA to market the Crescendo Product in the United States. The
License Option will expire, to the extent not previously
exercised, 30 days after the expiration of ALZA's option to
purchase all of the outstanding Crescendo Shares, described
below.  If and to the extent the License Option is exercised as
to any Crescendo Product, ALZA will acquire a perpetual,
exclusive license (with the right to sublicense) to develop,
make, have made and use the licensed product, and to sell and
have sold the licensed product in the country or countries as to
which the License Option is exercised.

     Under the License Agreement for each licensed product (a
form of which is attached to the License Option Agreement), ALZA
will make payments to Crescendo with respect to the licensed
product equal to 1% of net sales of the licensed product by ALZA
and its sublicensees, distributors and marketing partners, plus
an additional 0.1% of such net sales for each full $1 million of
development costs (as defined in the Development Agreement) of
the licensed product that have been paid by Crescendo, not to
exceed 2.5% of net sales in the first year a licensed product is
sold in a major market country, and not to exceed 3% for the
following two years.  ALZA has the right to buy out Crescendo's
right to receive payments for licensed products on a country-by-
country or global basis in accordance with a formula set forth in
the License Agreement.

    Pursuant to Crescendo's Restated Certificate of Incorporation,
ALZA has a purchase option which gives ALZA the right to purchase
all (but not less than all) of the Crescendo Shares (the "Purchase
Option").  The Purchase Option will be exercisable by written notice
to Crescendo at any time until January 31, 2002, provided that such
date will be extended for successive six month periods if, as of any
July 31 or January 31 beginning with July 31, 2001, Crescendo has
not paid (or accrued expenses for) at least 95% of Available Funds
pursuant to the Development Agreement. In any event, the Purchase
Option will terminate on the 60th day after Crescendo provides ALZA
with a statement that, as of the end of any calendar month, there
are less than $2.5 million of Available Funds remaining, accompanied
by a report of Crescendo's independent auditors.

   If the Purchase Option is exercised, the exercise price will
be the greatest of:

 (a)(i) 25 times the actual payments made by or due from ALZA to
   Crescendo under the Development Agreement and the License
   Agreement for any product (and, in addition, such payments as
   would have been made by or due from ALZA to Crescendo if ALZA
   had not previously exercised its payment buy-out option with
   respect to any such payments) for the four calendar quarters
   immediately preceding the quarter in which the Purchase
   Option is exercised (provided, however, that for any product
   which has not
   been commercially sold during each of such four calendar
   quarters, the portion of the exercise price for such product
   will be 100 times the average of the quarterly payments made
   by or due from ALZA to Crescendo for each of such calendar
   quarters during which such product was commercially sold)
   less (ii) any amounts previously paid to exercise any payment
   buy-out option;
   
 (b) the fair market value of one million shares of ALZA common
   stock;
   
 (c) $325 million less all amounts paid by or due from Crescendo
   under the Development Agreement to the date the Purchase
   Option is exercised; and
 
 (d) $100 million.
 
   In each case, the amount payable as the Purchase Option
exercise price will be reduced to the extent, if any, that
Crescendo's liabilities at the time of exercise (other than
liabilities under the Development Agreement, the Technology
License Agreement and the Services Agreement, described below)
exceed Crescendo's cash and cash equivalents, and short-term and
long-term investments (excluding the amount of Available Funds
remaining at such time).  ALZA may pay the exercise price in
cash, in ALZA common stock or in any combination of cash and ALZA
common stock.

   Crescendo and ALZA have entered into a Services Agreement
pursuant to which ALZA has agreed to provide Crescendo with
administrative services, including accounting and legal services,
on a fully-burdened cost reimbursement basis.  The Services
Agreement has a one-year term and will be renewed automatically
for successive one-year terms during the term of the Development
Agreement unless terminated by Crescendo at any time upon 60
days' written notice.  General and administrative expenses
incurred under this agreement for the three and six months ended
June 30, 1998 were $0.4 million and $0.7 million, respectively.
General and administrative expenses incurred under this agreement
for the period from inception through June 30, 1998 were $0.9
million.

Item 2.   Management's Discussion and Analysis of Financial
Condition
          and Results of Operations

Notice Concerning Forward-Looking Statements
    Some of the statements made in this Form 10-Q, and
particularly in the Management's Discussion and Analysis of
Financial Condition and Results of Operations, are forward-
looking in nature.  Forward-looking statements include but are
not limited to statements that are not historical facts and
statements including forms of the words "intend", "believe",
"will", "may", "could", "expect", "anticipate", "possible" and
similar terms.  The occurrence of the events described, and the
achievement of the intended results, are subject to the future
occurrence of many events, some or all of which are not
predictable or within Crescendo's control (including without
limitation any possible future actions by ALZA) and various risk
factors; therefore, actual results may differ materially from
those anticipated in any forward-looking statements.  The
significant risks related to Crescendo's business are those
associated with product selection, technology and product
development, clinical development, product manufacturing,
regulatory clearance to market products, changes in the health
care marketplace, patent and intellectual property matters,
medical and market acceptance of products (including third party
reimbursement), commercializing products (including competition),
conflicts of interest between ALZA and Crescendo and the risk of
a lack of funds to complete the development of products.  Such
risks are described in more detail in Crescendo's Annual Report
on Form 10-K for the year ended December 31, 1997.

Results of Operations

     Revenues, consisting of net interest and investment income
earned on invested funds, were approximately $3.4 million and
$7.2 million for the three months and six months ended June 30,
1998, respectively.  For the period from Crescendo's inception
(June 26, 1997) through June 30, 1998, revenues were $11.3
million.  As Crescendo's funds are used under the Development
Agreement and to pay the Technology Fee, lower cash balances will
be available for investment and, therefore, interest and
investment income is expected to decrease. During the period in
which all Crescendo Products are under development and
applications for regulatory clearance are submitted and reviewed,
Crescendo does not anticipate revenues other than from interest
and investment income.  If and when any Crescendo Product
receives regulatory clearance and is successfully commercialized,
Crescendo will derive revenue from the license or sale of such
product.

     Crescendo incurred research and development expenses of
approximately $28.6 million and $50.0 million for the three
months and six months ended June 30, 1998, respectively. For the
period from inception through June 30, 1998, Crescendo recorded
research and development expenses of $82.3 million.  These
expenses related primarily to development of the Initial Products
from August 25, 1997, the date TDC ceased funding such products,
through June 30, 1998 and payment of Technology Fees of $3.0
million and $6.0 million to ALZA during the three months and six
months ended June 30, 1998, respectively($10.0 million from
inception through June 30, 1998).  Crescendo's research and
development expenses are expected to continue at approximately
current levels during 1998, although quarterly fluctuations can
be expected.

     General and administrative expenses for the three months and
six months ended June 30, 1998 were $0.4 million and $0.7
million, respectively. For the period from inception through June
30, 1998, general and administrative expenses were $0.9 million.
Expenses incurred by Crescendo under its Services Agreement with
ALZA were approximately $75,000 and $125,000 for the three months
and six months ended June 30, 1998, respectively. For the period
from inception through June 30, 1998, expenses incurred by
Crescendo under its Services Agreement with ALZA were
approximately $217,000.

     The results of operations of Crescendo currently reflect
primarily interest and investment income on the funds contributed
by ALZA, and research and development expenses related to
development of Crescendo Products and the Technology Fee.
Crescendo's net loss for the three months and six months ended
June 30, 1998 was $25.6 million or $5.16 per share and $43.5
million or $8.76 per share, respectively. The net loss from its
inception through June 30, 1998 was $71.9 million or $19.24 per
share.  Crescendo is expected to continue to record significant
net losses in future periods, as product development expenses
under its agreements with ALZA are expected to continue to exceed
income.

     Under its agreements with ALZA, Crescendo utilizes ALZA's
operating and accounting systems maintained by ALZA.  ALZA has
indicated to Crescendo that the majority of ALZA's operating and
accounting systems are year 2000 compliant.  Also, Crescendo has
requested confirmation of year 2000 compliance from its
investment managers.  Crescendo therefore does not currently
expect its financial condition or results of operations to be
materially adversely affected by year 2000 issues.

Liquidity and Capital Resources

     On September 29, 1997, ALZA contributed $300 million in cash
to Crescendo in exchange for the Crescendo Shares.  On September
30, 1997, ALZA distributed the Crescendo Shares to holders of
ALZA common stock and ALZA's outstanding convertible subordinated
debentures, and Crescendo commenced operations.  The funds
contributed by ALZA, plus investment income earned thereon, are
used primarily to fund the development of Crescendo Products and
to conduct related activities. Funds not immediately required for
development activities are  invested in low-risk securities.

     At June 30, 1998 and December 31, 1997, Crescendo had cash,
cash equivalents and short - and long-term investments of
approximately $241.5 million and 285.2 million, respectively.
Crescendo's cash expenditures for operating activities were
approximately $44.0 million for the six months ended June 30,
1998 and approximately $58.4 million for the period from
inception through June 30, 1998. As Crescendo's funds continue to
be utilized under the Development Agreement and to pay the
Technology Fee to ALZA, increasingly lower cash balances will be
available for investment.

    Based on anticipated spending levels for the continued
development of all the current Crescendo Products, it is expected
that Crescendo's funds for product development will be exhausted
during the next few years.  At that time, product development
funding by Crescendo will cease.  However, several factors could
impact the level and timing of Crescendo funding, including the
addition of any new Crescendo Products, the discontinuation of the
development of any Crescendo Products, any commercial arrangements
between ALZA and other companies which would cause ALZA to exercise
its License Option with respect to any Crescendo Product, any change
in the number of projects advancing to or continuing in later stages
of development or any adjustments in the rate of spending on
products currently in development.

    When Crescendo's cash available for product development is
exhausted, certain critical timetables will be triggered.  First,
ALZA's Purchase Option with respect to all of the Crescendo Shares
will terminate on the 60th day after Crescendo provides ALZA with a
statement that, as of the end of any calendar month, there are less
than $2.5 million of Available Funds remaining, accompanied by a
report of Crescendo's independent auditors.  In addition, ALZA has
the right, for 30 days after expiration of the Purchase Option, to
license any or all Crescendo Products which have not yet been
licensed, on a product-by-product and country-by-country basis.
ALZA is under no obligation to exercise the Purchase Option or the
License Option with respect to any Crescendo Product and will do so
only if ALZA determines that it is in the best interests of ALZA and
its stockholders at the time the decision is made.  In the event
that ALZA does not exercise the Purchase Option or the License
Option for all Crescendo Products after Crescendo's cash available
for product development is exhausted, Crescendo will not have funds
to continue or complete development of any remaining products.


Item 3.   Quantitative and Qualitative Disclosures about Market Risk

    Not Applicable.


PART II.  OTHER INFORMATION

Item 4.   Submission of Matters to a Vote of Security Holders

   (a)  The annual meeting of stockholders of Crescendo was held on
      May 7, 1998.
(b)  At the annual meeting, stockholders approved the following
proposal:

          Election of Directors:   Votes For      Votes Withheld

          Gary L. Neil, Ph.D.      4,292,420           7,432

          Terrence F. Blaschke, MD 4,292,277           7,575
   
   
Item 6.   Exhibits and Reports on Form 8-K

   (a)    Exhibits:
     
     27   Financial Data Schedule


   (b)    No reports on Form 8-K were filed during the quarter.

                           SIGNATURES



    Pursuant to the requirements of the Securities Exchange Act
of 1934, the registrant has duly caused this report to be signed
on its behalf by the undersigned thereunto duly authorized.




                                   Crescendo Pharmaceuticals Corporation



Date: August 13, 1998         By:          /s/ Gary L. Neil
                                    _________________________________
                                             Gary L. Neil
                                            President and
                                        Chief Executive Officer


Date: August 13, 1998         By:          /s/ David R. Hoffmann
                                   _________________________________
                                          David R. Hoffmann
                                        Vice President, Finance
                                            and Secretary


<TABLE> <S> <C>

<ARTICLE> 5
<LEGEND>
This schedule contains summary financial information extracted from the
financial statements included in Part I, Item 1 of Form 10-Q dated June 30, 1998
and is qualified in its entirety by reference to such financial statements.
</LEGEND>
<CIK> 0001042138
<NAME> CRESCENDO PHARMACEUTICALS CORPORATION
<MULTIPLIER> 1,000
       
<S>                             <C>
<PERIOD-TYPE>                   6-MOS
<FISCAL-YEAR-END>                          DEC-31-1998
<PERIOD-END>                               JUN-30-1998
<CASH>                                          59,188
<SECURITIES>                                    68,528
<RECEIVABLES>                                    2,349
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                               130,375
<PP&E>                                               0
<DEPRECIATION>                                       0
<TOTAL-ASSETS>                                 244,424
<CURRENT-LIABILITIES>                           16,171
<BONDS>                                              0
                                0
                                          0
<COMMON>                                            51
<OTHER-SE>                                     228,202
<TOTAL-LIABILITY-AND-EQUITY>                   244,424
<SALES>                                              0
<TOTAL-REVENUES>                                 7,202
<CGS>                                                0
<TOTAL-COSTS>                                        0
<OTHER-EXPENSES>                                50,704
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                   0
<INCOME-PRETAX>                               (43,502)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                           (43,502)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                  (43,502)
<EPS-PRIMARY>                                   (8.76)
<EPS-DILUTED>                                   (8.76)
        

</TABLE>


© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission