LJL BIOSYSTEMS INC
8-K, 1999-02-11
LABORATORY ANALYTICAL INSTRUMENTS
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<PAGE>
                                       

                        SECURITIES AND EXCHANGE COMMISSION

                              Washington, D.C. 20549

                                     FORM 8-K

                                  CURRENT REPORT 

      PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

                        Date of Report:  February 10, 1999


                               LJL BIOSYSTEMS, INC.
              (Exact name of registrant as specified in its charter)

                                    000-23647
                             (Commission File Number)

   DE                                      77-0360183
   (State or other jurisdiction of         (I.R.S. Employer Identification No.)
    incorporation)


                      405 TASMAN DRIVE, SUNNYVALE, CA  94089
             (Address of principal executive offices, with zip code)

                                  (408) 541-8787
               (Registrant's telephone number, including area code)

                                       N/A
          (Former name or former address, if changed since last report)

<PAGE>

ITEM 5.   OTHER EVENTS.

     On January 27, 1999, LJL BioSystems, Inc. a Delaware corporation (the 
"Company") announced that it had arranged a private placement (the "Private 
Placement") of 2,000,000 shares of the Company's Common Stock, at a purchase 
price of $3.50 per share, for a total of $7 million in cash.  The closing of 
the Private Placement took place on January 27, 1999.  The purchasers 
consisted of The Bay City Capital Fund I, L.P., The Kaufmann Fund, Inc., and 
Skyline Venture Partners, L.P.  The Company relied on Rule 506 of Regulation 
D under the Securities Act of 1933, as amended (the "Act"), which among other 
things, provides an exemption from registration requirements of the Act for 
sales to accredited investors (as defined by Rule 501(a) of Regulation D of 
the Act). Under the terms of the Private Placement, the Company has agreed to 
file a Registration Statement on Form S-3 within six months after the closing 
of the transaction to register the shares of the Company's Common Stock that 
were delivered to the investors at the closing.  The specific terms of the 
shares of Common Stock sold in the Private Placement are contained in Common 
Stock Purchase Agreement and Registration Rights Agreement attached as 
exhibits hereto and incorporated by reference herein.  Further details of 
this transaction are contained in the Company's press release dated January 
27, 1999, attached as an exhibit hereto and incorporated by reference herein.

ITEM 7.   FINANCIAL STATEMENTS AND EXHIBITS.

     (c)  Exhibits.

          Exhibit 4.4    Common Stock Purchase Agreement dated January 25, 
                         1999, by and among LJL BioSystems, Inc. and the 
                         Purchasers (as defined therein)


          Exhibit 4.5    Registration Rights Agreement dated January 27, 1999, 
                         by and among the Company and the Holders (as defined 
                         therein)

          Exhibit 99     LJL BioSystems, Inc. Press Release dated January 27, 
                         1999


                                      -2-
<PAGE>

                                   SIGNATURES


     Pursuant to the requirements of the Securities Exchange Act of 1934, the 
Registrant has duly caused this report to be signed on its behalf by the 
undersigned hereunto duly authorized.

                                   LJL BIOSYSTEMS, INC.



Date:  February 10, 1999           By: /s/  Lev J. Leytes
                                       -------------------------------------
                                       Lev J. Leytes
                                       President and Chief Executive Officer


                                      -3-
<PAGE>


                                   LJL BIOSYSTEMS, INC.
<TABLE>
<CAPTION>

 Exhibit Number    Description
<S>                <C>
 Exhibit 4.4       Common Stock Purchase Agreement
                   dated January 25, 1999 
                   by and among LJL BioSystems, Inc.
                   and the Purchasers (as defined
                   therein)

 Exhibit 4.5       Registration Rights Agreement dated
                   January 27, 1999, by and among the
                   Company and the Holders (as defined
                   therein)

 Exhibit 99        LJL BioSystems, Inc. Press Release
                   dated January 27, 1999
</TABLE>


                                      -4-


<PAGE>
                                       

                               LJL BIOSYSTEMS, INC.


                         COMMON STOCK PURCHASE AGREEMENT


                                 JANUARY 25, 1999

<PAGE>


                               LJL BIOSYSTEMS, INC.
                         COMMON STOCK PURCHASE AGREEMENT

     This Common Stock Purchase Agreement (the "AGREEMENT") is entered into 
as of this 25th day of January, 1999 (the "EFFECTIVE DATE") among LJL 
BioSystems, Inc., a Delaware corporation (the "COMPANY") and the investors 
listed on EXHIBIT A attached hereto (each a "PURCHASER" and together the 
"PURCHASERS").

                                    SECTION 1

                         SALE OF COMMON STOCK AND WARRANT

     1.1  SALE OF COMMON STOCK.  Subject to the terms and conditions hereof, 
on the Closing Date, as defined below, the Company will issue and sell to 
each Purchaser, and each Purchaser will purchase from the Company the number 
of whole shares of Common Stock, par value $0.001 per share, of the Company 
(the "PURCHASED COMMON STOCK"), calculated by dividing the dollar amount set 
forth opposite such Purchaser's name on EXHIBIT A by $3.50.

     1.2  CLOSING DATE.  The closing (the "CLOSING") of the purchase and sale 
of the Common Stock (referred to herein as the "SECURITIES") shall be held at 
the offices of Venture Law Group, 2800 Sand Hill Road, Menlo Park, California 
at 10:00 a.m. on January 27, 1999, or at such other time and place upon which 
the Company and the Purchasers shall mutually agree (the date of the Closing 
is hereinafter referred to as the "CLOSING DATE").

     1.3  DELIVERY.  At the Closing, the Company will deliver to each 
Purchaser a certificate or certificates representing the shares of Common 
Stock purchased by such Purchaser, against payment of the purchase price 
therefor, by wire transfer or certified or cashier's check drawn on a United 
States ("U.S.") bank.

     1.4  LEGEND.  The certificate or certificates for the Securities shall 
be subject to a legend restricting transfer under the Securities Act of 1933, 
as amended (the "SECURITIES ACT") and referring to restrictions on transfer 
herein, such legend to be substantially as follows:

     "THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED 
UNDER THE SECURITIES ACT OF 1933, AND HAVE BEEN ACQUIRED FOR INVESTMENT AND 
NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF.  
NO SUCH SALE OR DISPOSITION MAY BE EFFECTED WITHOUT (A) AN EFFECTIVE 
REGISTRATION STATEMENT RELATED THERETO, OR (B) AN OPINION OF COUNSEL FOR THE 
COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 
1933, AS AMENDED, OR (C) FULL COMPLIANCE WITH THE PROVISIONS OF RULE 144 
UNDER THE ACT."

     In addition, the certificates for the Securities issued and sold to The 
Bay City Capital Fund I, L.P. ("Bay City Fund") and Skyline Venture Partners, 
L.P. shall include appropriate legends to reflect such Purchasers' status as 
affiliates of the Company.

<PAGE>
                                       
                                    SECTION 2

                  REPRESENTATIONS AND WARRANTIES OF THE COMPANY

     The Company hereby represents and warrants to the Purchasers that as of 
the Effective Date:

     2.1  ORGANIZATION.  The Company is a corporation duly organized and 
validly existing under the laws of the State of Delaware and is in good 
standing under such laws.  The Company has requisite corporate power and 
authority to own, lease and operate its properties and assets, and to carry 
on its business as presently conducted and as proposed to be conducted.  The 
Company is qualified to do business as a foreign corporation in each 
jurisdiction in which the ownership of its property or the nature of its 
business requires such qualification, except where failure to so qualify 
would not have a materially adverse effect on the Company.  The Company has 
no subsidiaries or equity interest in any other entity other than LJL 
BioSystems Ltd., a U.K. subsidiary.

     2.2  CAPITALIZATION.  The authorized capital stock of the Company 
consists of 50,000,000 shares of Common Stock, $0.001 par value, of which at 
December 31, 1998, approximately 10,524,493 shares were issued and 
outstanding, and 2,000,000 shares of Preferred Stock, $0.001 par value, of 
which no shares of Preferred Stock were issued and outstanding and warrants 
exercisable for 73,679  shares of Common Stock were issued and outstanding.  
Since December 31, 1998, no shares of the Company's Common or Preferred Stock 
have been issued, except pursuant to the exercise of outstanding options and 
except pursuant to the Company's 1998 Employee Stock Purchase Plan.  All such 
issued and outstanding shares have been duly authorized and validly issued 
and are fully paid and nonassessable.  As of December 31, 1998, there were 
options outstanding for approximately 1,509,053  shares of Common Stock and 
approximately 890,144 shares available for future issuance.  Except as 
described in this Section 2.2, there are no other options, warrants, 
conversion privileges or other contractual rights presently outstanding to 
purchase or otherwise acquire any authorized but unissued shares of the 
Company's capital stock or other securities other than pursuant to the 
Company's stock option plans and Employee Stock Purchase Plan.  All of the 
issued and outstanding securities of the Company have been issued in 
compliance with all applicable federal and state securities laws.

     2.3  AUTHORIZATION.  The Company has all corporate right, power and 
authority to enter into this Agreement and the Registration Rights Agreement 
substantially in the form attached hereto as EXHIBIT D (the "Registration 
Rights Agreement") and to consummate the transactions contemplated hereby and 
thereby. All corporate action on the part of the Company, its directors and 
stockholders necessary for the authorization, execution, delivery and 
performance of this Agreement and the Registration Rights Agreement by the 
Company, and the authorization, sale, issuance and delivery of the Securities 
being sold hereunder by the Company has been taken.  This Agreement and the 
Registration Rights Agreement have been duly executed and delivered by the 
Company and constitute legal, valid and binding obligations of the Company 
enforceable in accordance with their respective terms, subject to laws of 
general application relating to bankruptcy, insolvency and the relief of 
debtors and rules of law 

                                      -2-
<PAGE>

governing specific performance, injunctive relief or other equitable 
remedies, and to limitations of public policy as they may apply to Section 
1.7 of the Registration Rights Agreement. Upon their issuance and delivery 
pursuant to this Agreement, all of the Securities being sold by the Company 
hereunder will be duly and validly issued, fully paid and nonassessable and 
free and clear of any liens and encumbrances other than restrictions on 
transfer pursuant to state and federal securities laws.  There are no 
statutory, contractual or other preemptive rights, rights of first refusal, 
co-sale rights or similar rights with respect to the issuance and sale of the 
Securities.

     2.4  VALIDITY OF SECURITIES.  The Securities, when issued, sold and 
delivered by the Company in accordance with the terms of this Agreement, will 
be duly and validly issued, fully-paid and nonassessable.  Based in part upon 
the representations of the Purchasers in this Agreement, the offer, sale and 
issuance of the Securities will be made in compliance with all applicable 
federal and state securities laws.

     2.5  NO CONFLICT.  The execution and delivery of this Agreement and the 
Registration Rights Agreement do not, and the consummation of the 
transactions contemplated hereby and thereby will not, conflict with, or 
result in any violation of, or default (with or without notice or lapse of 
time, or both), or give rise to a right of termination, cancellation or 
acceleration of any obligation or to a loss of a material benefit, under, any 
provision of the Certificate of Incorporation or Bylaws of the Company or any 
material agreement attached as an exhibit to the Company's SEC Documents, or 
any judgment, order, decree, statute, law, ordinance, rule or regulation 
applicable to the Company, its properties or assets, which conflict, 
violation, default or right would have a material adverse effect on the 
business, properties, prospects or financial condition of the Company.

     2.6  ACCURACY OF REPORTS; FINANCIAL STATEMENTS.  All reports required to 
be filed with the Securities and Exchange Commission (the "SEC") by the 
Company since March 18, 1998 (the date of the Company's initial public 
offering) through the date of this Agreement under the Securities Exchange 
Act of 1934, as amended (the "Exchange Act"), copies of which have been made 
available to each Purchaser (the "SEC Documents"), have been duly and timely 
filed, were in substantial compliance with the requirements of their 
respective forms when filed, were complete and correct in all material 
respects as of the dates at which the information was furnished, and 
contained (as of such dates) no untrue statement of a material fact nor 
omitted to state a material fact necessary in order to make the statements 
made therein in light of the circumstances in which made not misleading.  The 
financial statements of the Company included in the SEC Documents (the 
"Financial Statements") comply as to form in all material respects with 
applicable accounting requirements and with the published rules and 
regulations of the SEC with respect thereto.  The Financial Statements have 
been prepared in accordance with generally accepted accounting principles 
consistently applied and fairly present the consolidated financial position 
of the Company at the dates thereof and the consolidated results of 
operations and consolidated cash flows for the periods then ended (subject, 
in the case of unaudited statements, to normal, recurring adjustments).  
Since the date of the last filing of an SEC Document, there has not been any 
material adverse change in the assets, business, financial condition or 
results of operations of the Company; PROVIDED, HOWEVER, that changes in the 
ordinary course of business, including but not limited to the use of cash and 
increase in liabilities, shall not be deemed to be a 

                                      -3-
<PAGE>

material adverse change.

     2.7  GOVERNMENTAL CONSENTS, ETC. No consent, approval or authorization 
of or designation, declaration or filing with any governmental authority on 
the part of the Company is required in connection with the valid execution 
and delivery of this Agreement or the Registration Rights Agreement, or the 
consummation of any other transaction contemplated hereby and thereby, except 
such filings as may be required to be made with the SEC, the National 
Association of Securities Dealers, Inc. and with governmental authorities for 
purposes of effecting compliance with the securities and blue sky laws in the 
states in which Securities are offered and/or sold (which compliance will be 
effected in accordance with such laws).

     2.8  LITIGATION.  There is no action, suit, proceeding, claim, 
arbitration or investigation pending or as to which the Company has received 
any notice of assertion against the Company, which could reasonably be 
expected to result in a material adverse effect on the business, properties, 
financial condition or operations of the Company.

     2.9  REGISTRATION RIGHTS.  Except for the rights set forth in the 
Amended and Restated Investors' Rights Agreement dated June 17, 1997, a copy 
of which has been made available to each Purchaser, the Company is not 
presently under any obligation and has not granted any rights to register its 
securities under the Securities Act with respect to any of its presently 
outstanding securities, which rights would be implicated with respect to the 
registration contemplated by the Registration Rights Agreement and which 
rights have not been waived by the holders thereof.

     2.10 NO MATERIAL DEFAULT.  The Company is not in violation of or default 
in any material respect under any provision of (a) its Certificate of 
Incorporation or Bylaws, (b) any federal or state judgment, order, decree, 
statute, law, ordinance, rule or regulation applicable to the Company, or (c) 
any material agreement attached as an exhibit to the Company's SEC Documents, 
except such violations or defaults as would not have a material adverse 
effect on the business, properties, prospects or financial condition of the 
Company.

     2.11 LISTING.  The Company's Common Stock is traded on The Nasdaq 
National Market.

     2.12 DISCLOSURE.  No representation or warranty of the Company contained 
in this Agreement or the exhibits attached hereto (when read together and 
taken as a whole), contains any untrue statement of a material fact or omits 
to state a material fact necessary in order to make the statements contained 
herein or therein in light of the circumstances under which they were made 
not misleading.
                                       
                                   SECTION 3

                REPRESENTATIONS AND WARRANTIES OF THE PURCHASERS

     Each Purchaser, severally and not jointly with other Purchasers, hereby 
represents and warrants to the Company as follows as of the Effective Date:

                                      -4-
<PAGE>

     3.1  INVESTMENT.  Such Purchaser will acquire the Securities purchased 
from the Company pursuant to this Agreement for investment for its own 
account, not as a nominee or agent and not with a view to or for resale in 
connection with any distribution thereof.  Purchaser understands that the 
Securities purchased by such Purchaser from the Company pursuant to this 
Agreement have not been registered under the Securities Act by reason of a 
specific exemption from the registration provisions of the Securities Act 
which depends upon, among other things, the bona fide nature of such 
Purchaser's investment intent and the accuracy of such Purchaser's 
representations as expressed herein.

     3.2  ACCREDITED INVESTOR.  Such Purchaser is an "accredited investor" as 
defined by Rule 501(a) of the Securities Act of 1933, as amended (the 
"Securities Act").  The SEC documents have been made available to each 
Purchaser, and each Purchaser has received all the information it has 
requested regarding the Company.  Such Purchaser has such business and 
financial experience as is required to give it the capacity to protect its 
own interests in connection with the purchase of the Securities.

     3.3  AUTHORITY.  This Agreement and the Registration Rights Agreement 
have been duly executed and delivered by such Purchaser and constitute legal, 
valid and binding obligations of such Purchaser, enforceable in accordance 
with their respective terms, subject to laws of general application relating 
to bankruptcy, insolvency and the relief of debtors and rules of law 
governing specific performance, injunctive relief or other equitable 
remedies, and to limitations of public policy as they may apply to Section 
1.7 of the Registration Rights Agreement.  The execution and delivery of this 
Agreement and the Registration Rights Agreement do not, and the consummation 
of the transactions contemplated hereby and thereby will not, conflict with 
or result in any violation of any obligation under any judgment, order, 
decree, statute, law, ordinance, rule or regulation applicable to such 
Purchaser.

     3.4  GOVERNMENT CONSENTS, ETC.  No consent, approval or authorization of 
or designation, declaration or filing with any governmental authority on the 
part of such Purchaser is required in connection with the valid execution and 
delivery of this Agreement, or the offer, sale or issuance of the Securities, 
or the consummation of any other transaction contemplated hereby.

     3.5  INVESTIGATION.  Such Purchaser has had a reasonable opportunity to 
discuss the Company's business, management and financial affairs with the 
Company's management.
                                       
                                   SECTION 4

                   CONDITIONS TO OBLIGATIONS OF THE PURCHASERS

     The obligations of each Purchaser to the Company under this Agreement 
are subject to the fulfillment, on or before the Closing, of each of the 
following conditions, unless otherwise waived:

     4.1  REPRESENTATIONS AND WARRANTIES CORRECT.  The representations and 
warranties made by the Company in Section 2 shall be true and correct in all 
material respects when made 

                                      -5-
<PAGE>

and on and as of the Closing Date with the same effect as though such 
representations and warranties had been made on and as of the Closing Date.

     4.2  COVENANTS.  All covenants, agreements and conditions contained in 
this Agreement to be performed by the Company on or prior to the Closing Date 
shall have been performed or complied with in all material respects.

     4.3  NO ACTION, ETC. PENDING.  There shall not at Closing be in effect 
any action, order, or other proceeding, preventing, enjoining or otherwise 
restraining the transactions contemplated by this Agreement.

     4.4  NO LAW PROHIBITING OR RESTRICTING SALE.  There shall not be in 
effect any law, rule or regulation prohibiting or restricting such sale, or 
requiring any consent or approval of any person which shall not have been 
obtained to issue the Securities (except as otherwise referenced in this 
Agreement).

     4.5  COMPLIANCE CERTIFICATE.  The Company shall have delivered to the 
Purchasers a certificate substantially in the form attached hereto as EXHIBIT 
B executed by a duly authorized officer, dated the Closing Date, certifying 
to the fulfillment of the conditions specified in Sections 4.1 and 4.2 and 
certifying that, since the date of the Company's most recent filing with the 
SEC, there has not been any material adverse change in the assets, 
liabilities, financial condition or operations of the Company; PROVIDED, 
HOWEVER, that changes in the ordinary course of business, including but not 
limited to the use of cash and increase in liabilities, shall not be deemed 
to be a material adverse change.

     4.6  REGISTRATION RIGHTS AGREEMENT.  On or before the Closing, the 
Company and the Purchasers shall have executed and delivered a counterpart of 
the Registration Rights Agreement in the form attached hereto as EXHIBIT C.

     4.7  OPINION OF COMPANY COUNSEL.  The Purchasers shall have received 
from Venture Law Group, counsel for the Company, an opinion, dated as of the 
Closing, substantially in the form attached hereto as EXHIBIT D.

     4.8  DIRECTOR.  The Company shall have taken all actions necessary to 
ensure that John Diekman shall be appointed, effective immediately after the 
Closing, to serve on the Company's board of directors.
                                      
                                  SECTION 5

                       CONDITIONS TO OBLIGATIONS OF THE COMPANY

     The obligations of the Company under this Agreement are subject to the 
fulfillment on or prior to the Closing of each of the following conditions, 
unless otherwise waived:

     5.1  REPRESENTATIONS AND WARRANTIES CORRECT.  The representations and 
warranties made by the Purchasers in Section 3 hereof shall be true and 
correct in all material respects when 

                                      -6-
<PAGE>

made and on and as of the Closing Date with the same effect as though such 
representations and warranties had been made on and as of the Closing Date.

     5.2  PERFORMANCE.  All covenants, agreements and conditions contained in 
this Agreement to be performed by the Purchasers on or prior to the Closing 
Date shall have been performed or complied with in all material respects.

     5.3  NO ACTION, ETC. PENDING.  There shall not at Closing be in effect 
any action, order or other proceeding, preventing, enjoining or otherwise 
restraining the transactions contemplated by this Agreement.

     5.4  NO LAW PROHIBITING OR RESTRICTING SUCH SALE.  There shall not be in 
effect any law, rule or regulation prohibiting or restricting such sale, or 
requiring any consent or approval of any person which shall not have been 
obtained to issue the Securities (except as otherwise provided in this 
Agreement).
                                       
                                   SECTION 6

                             POST-CLOSING COVENANTS

     6.1  POST-CLOSING COVENANT OF THE COMPANY.  Until the earlier of (i) the 
date upon which Bay City Fund and its affiliates beneficially own 75% or less 
of the shares of Purchased Common Stock that Bay City Fund purchases 
hereunder or (ii) four (4) years from the Closing, the Company shall, subject 
to the fiduciary obligations of the Board of Directors to the Company's 
stockholders based on advice of legal counsel, (i) nominate and include in 
the Company proxy statement a representative designated by Bay City Capital 
LLC ("BAY CITY") as a Class II director of the Company's Board of Directors 
at each annual meeting of stockholders of the Company where the class of 
which such designee is a member is up for election, and (ii) in the event 
that any such designee shall resign or be removed as a director for any 
reason during the period that this Section 6.1 is in effect, fill the vacancy 
resulting thereby by a designee of Bay City.  The Company shall provide all 
rights and benefits of indemnity to such designee as are provided such other 
outside directors.

     6.2  POST-CLOSING COVENANT OF THE PURCHASERS. Until the earlier of (i) 
the date upon which Bay City Fund beneficially owns 75% or less of the Common 
Stock purchased by Bay City Fund pursuant to this Agreement or (ii) four (4) 
years from the Closing, the Purchasers (which term, for the purposes of this 
Section 6.2, shall include all affiliates of the Purchasers that may from 
time to time beneficially own shares of Common Stock) shall take such action 
as may be required so that all shares of voting stock of the Company 
beneficially owned by the Purchasers are voted for the nominee to the Board 
of Directors of the Company which is nominated consistent with the provisions 
of Section 6.1 above.

                                      -7-
<PAGE>

                                    SECTION 7

                                  MISCELLANEOUS

     7.1  GOVERNING LAW.  This Agreement and all acts and transactions 
pursuant hereto and the rights and obligations of the parties hereto shall be 
governed, construed and interpreted in accordance with the laws of the State 
of California, without giving effect to principles of conflicts of law.

     7.2  MAINTENANCE OF LISTING.  For so long as the Company is obligated to 
keep in effect any registration statement provided for under the Registration 
Rights Agreement, the Company will use its reasonable best efforts to 
maintain its listing on The Nasdaq National Market or a national securities 
exchange, as defined in the Exchange Act.

     7.3  FILINGS.  The parties shall consult and fully cooperate with and 
provide assistance to each other in preparing and filing as soon as 
practicable all consents, approvals and authorizations necessary or advisable 
to be made or obtained from any third-party or governmental agency in order 
to consummate the transactions contemplated hereby.

     7.4  SURVIVAL.  Unless otherwise set forth in this Agreement, the 
representations and warranties of the Company and the Purchasers contained in 
or made pursuant to this Agreement shall terminate six (6) months following 
the Closing; provided, however, that the covenants in Section 6 shall survive 
for the terms stated therein.

     7.5  SUCCESSORS AND ASSIGNS.  This Agreement shall be binding upon and 
shall inure to the benefit of the parties hereto and their respective 
successors and assigns.

     7.6  ENTIRE AGREEMENT; AMENDMENT.  This Agreement, the Registration 
Rights Agreement and the other documents delivered pursuant hereto constitute 
the full and entire understanding and agreement between the parties with 
regard to the subject matter hereof and thereof and supersede all prior 
agreements and understandings among the parties relating to the subject 
matter hereof.  Neither this Agreement nor any term hereof may be amended, 
waived, discharged or terminated other than by a written instrument signed by 
the party against which enforcement of any such amendment, waiver, discharge 
or termination is sought.

     7.7  NOTICES AND DATES.  Unless otherwise provided herein, any notice 
required or permitted by this Agreement shall be in writing and shall be 
deemed sufficient upon delivery, when delivered personally or by overnight 
courier and addressed to the party to be notified at such party's address as 
set forth on EXHIBIT A hereto, or to the Company at its address specified on 
its signature page hereto, or as subsequently modified by written notice. In 
the event that any date provided for in this Agreement falls on a Saturday, 
Sunday or legal holiday, such date shall be deemed extended to the next 
business day.

     7.8  BROKERS.

          (a)  The Company has not engaged, consented to or authorized any
broker, 

                                      -8-
<PAGE>

finder or intermediary to act on its behalf, directly or indirectly, as a 
broker, finder or intermediary in connection with the transactions 
contemplated by this Agreement.  The Company hereby agrees to indemnify and 
hold harmless the Purchasers from and against all fees, commissions or other 
payments owing to any party acting on behalf of the Company hereunder.

          (b)  No Purchaser has engaged, consented to or authorized any 
broker, finder or intermediary to act on its behalf, directly or indirectly, 
as a broker, finder or intermediary in connection with the transactions 
contemplated by this Agreement.  Each Purchaser hereby agrees to indemnify 
and hold harmless the Company from and against all fees, commissions or other 
payments owing to any party acting on behalf of such Purchaser hereunder.

     7.9  SEVERABILITY.  If any term, provision, covenant or restriction of 
this Agreement is held by a court of competent jurisdiction to be invalid, 
void or unenforceable, the remainder of the terms, provisions, covenants and 
restrictions of this Agreement shall remain in full force and effect and 
shall in no way be affected, impaired or invalidated.

     7.10 COSTS AND EXPENSES.  Each party hereto shall pay its own costs and 
expenses incurred in connection herewith, including the fees of its counsel, 
auditors and other representatives, whether or not the transactions 
contemplated herein are consummated.

     7.11 NO THIRD PARTY RIGHTS.  Nothing in this Agreement shall create or 
be deemed to create any rights in any person or entity not a party to this 
Agreement.

     7.12 PUBLICITY.  The Purchasers and the Company shall not issue any 
public statement concerning the transactions contemplated by this Agreement 
without the reasonable prior written consent of the parties named in such 
public statement; PROVIDED, HOWEVER, that the parties may disclose the 
transaction or the terms hereof or thereof from time to time without the 
approval of the party whose name is disclosed if (i) such approval has been 
requested and not received and such party concludes (after consulting with 
counsel) that it is required by law to disclose the transaction or the terms 
thereof or (ii) to the extent that similar disclosure has been previously 
approved pursuant to this Section 7.12.

     7.13 CAPTIONS AND HEADINGS.  The captions and headings used herein are 
for convenience and ease of reference only and are not intended to be a part 
of or to affect the meaning or interpretation of this Agreement.

     7.14 COUNTERPARTS.  This Agreement may be executed in counterparts, and 
each such counterpart shall be deemed an original for all purposes.
                                       
                             [SIGNATURE PAGES FOLLOW]

                                      -9-
<PAGE>

     IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be 
executed by their respective authorized officers as of the date first written 
above.

                                        LJL BIOSYSTEMS, INC.

                                        By:  /s/ Lev J. Leytes
                                             ----------------------------------
                                        Its: President
                                             ----------------------------------

<PAGE>


     IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be 
executed by their respective authorized officers as of the date first written 
above.

                                        THE BAY CITY CAPITAL FUND I, L.P.


                                        By:  BAY CITY CAPITAL MANAGEMENT LLC
                                        Its: General Partner


                                        By:  /s/ Roger H. Salquist
                                             ----------------------------------
                                             Name: Roger H. Salquist
                                                   ----------------------------
                                             Title: Managing Director
                                                   ----------------------------

<PAGE>

     IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be 
executed by their respective authorized officers as of the date first written 
above.

                                        SKYLINE VENTURE PARTNERS, L.P.


                                        By:  Skyline Venture Management LLC
                                        Its: General Partner


                                        By:  /s/ John Freund
                                             ----------------------------------
                                             John Freund
                                             Managing Director

<PAGE>

     IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be 
executed by their respective authorized officers as of the date first written 
above.

                                        THE KAUFMANN FUND, INC.



                                        By:  /s/ Hans P. Utsch
                                             ----------------------------------
                                             Hans P. Utsch
                                             President

<PAGE>
                                       

                                   EXHIBIT A

                             SCHEDULE OF PURCHASERS
<TABLE>
<CAPTION>

                                                Number of Securities of                     Aggregate
      Name and Address                               Common Stock                        Purchase Price
      ----------------                               ------------                        --------------
<S>                                             <C>                                      <C>
The Bay City Capital Fund I, L.P.                      857,143 
750 Battery Street, Suite 600                                                            $ 3,000,000.50
San Francisco, CA  94111


The Kaufmann Fund, Inc.                                857,143                           $ 3,000,000.50
140 E. 45th Street, 43rd Floor                        
New York, NY  10017


Skyline Venture Partners, L.P.                         285,714                           $   999,999.00
525 University Avenue, Suite 701
Palo Alto, CA  94301
                                                     ---------                           --------------

     TOTAL:                                          2,000,000                           $ 7,000,000.00
</TABLE>

<PAGE>
                                       
                                   EXHIBIT B

                              LJL BIOSYSTEMS, INC.

                             COMPLIANCE CERTIFICATE


     The undersigned, Lev J. Leytes, hereby certifies as follows:

     1.   The undersigned is the duly elected President and Chief Executive 
Officer of LJL BioSystems, Inc., a Delaware corporation (the "COMPANY").

     2.   The representations and warranties of the Company set forth in 
Section 2 of the Common Stock Purchase Agreement (the "AGREEMENT") dated 
January 25, 1999  are true and correct in all material respects as though 
made on and as of the date hereof. 

     3.   The Company has performed and complied with all covenants, 
agreements, obligations and conditions contained in the Agreement to be 
performed by the Company on or prior to the Closing Date.

     4.   Since the date of the Company's most recent filing with the SEC, 
there has not been any material adverse change in the assets, liabilities, 
financial condition, or operations of the Company; PROVIDED, HOWEVER, that 
changes in the ordinary course of business, including but not limited to the 
use of cash and increase in liabilities, shall not be deemed to be a material 
adverse change.

     The undersigned has executed this Certificate this 27th day of January, 
1999.


                                            /s/ Lev J. Leytes
                                            ----------------------------------
                                            Lev J. Leytes, President and Chief 
                                            Executive Officer

<PAGE>
                                       
                                   EXHIBIT C

                         REGISTRATION RIGHTS AGREEMENT



                      (Included herewith as Exhibit 4.5)


<PAGE>

                                   EXHIBIT D

                           OPINION OF COMPANY COUNSEL


<PAGE>

                           [Venture Law Group Letterhead]


                                 January 27, 1999
 

To the Purchasers Listed on EXHIBIT A to the
LJL BioSystems, Inc. Common Stock
Purchase Agreement

Ladies and Gentlemen:

     We have acted as counsel for LJL Biosystems, Inc., a Delaware 
corporation (the "COMPANY"), in connection with the sale by the Company to 
you of shares of the Company's Common Stock pursuant to the Common Stock 
Purchase Agreement dated January 25, 1999 (the "PURCHASE AGREEMENT"), by and 
among the Company and the persons listed on EXHIBIT A attached thereto (the 
"PURCHASERS"), and the negotiation, execution and delivery by the Company of 
the Registration Rights Agreement dated January 27, 1999 (the "REGISTRATION 
RIGHTS AGREEMENT") by and among the Company and the Purchasers.  This opinion 
is given to you in compliance with Section 4.7 of the Purchase Agreement.  
The Purchase Agreement and the Registration Rights Agreement are referred to 
herein collectively as the "AGREEMENTS."  Unless defined herein, capitalized 
terms have the meaning given to them in the Agreements.

     In rendering this opinion, we have made such legal and factual 
examinations and inquiries as we have deemed advisable or necessary for the 
purpose of rendering this opinion.  In addition, we have examined originals 
or copies of documents, corporate records and other writings which we 
consider relevant for the purposes of this opinion.  In such examination, we 
have assumed the genuineness of all signatures on original documents, the 
conformity to original documents of all copies submitted to us and the due 
execution and delivery of all documents where due execution and delivery are 
a prerequisite to the effectiveness thereof.  In making our examination of 
documents executed by entities other than the Company, we have assumed that 
each other entity had the power to enter into and perform all its obligations 
thereunder and we also have assumed the due authorization by each such other 
entity of all requisite actions and the due execution and delivery of such 
documents by each such other entity.

     Whenever our opinion herein with respect to the existence or absence of 
facts is indicated to be based on our knowledge or belief, it is intended to 
signify that in the course of our representation of the Company in connection 
with the transactions referred to in the first paragraph hereof, no 
information has come to the attention of Mark Weeks, Jason Lemkin or Laurel 
Finch (the only lawyers at Venture Law Group working on this transaction) 
that would give them actual knowledge of the existence or absence of such 
facts.  We have not undertaken any independent investigation to determine the 
existence or absence of such facts, and no inference as to our knowledge of 
the existence or absence of such facts should be drawn from the fact of our 
representation of the Company.

     In rendering the opinion set forth in paragraph (a) below as to the 
existence and good standing of the Company in Delaware, we have relied 
exclusively on a certificate of a recent date of public officials of the 
State of Delaware.

<PAGE>

January 27, 1999
Page 2

     In rendering the opinion expressed in paragraph (g) below, we have 
assumed and express no opinion with respect to the following:  (i) that the 
representations and warranties of the Purchasers set forth in the Agreements 
are true and complete; and (ii) that the information provided by the Company 
to the Purchasers in connection with such offer and sale is accurate and 
complete.  We have also assumed the accuracy of, and have relied upon, the 
Company's representations to us that the Company has made no offer to sell 
the Securities sold by it by means of any "GENERAL SOLICITATION," as defined 
in Regulation D under the Securities Act or the "PUBLICATION OF ANY 
ADVERTISEMENT" (as defined under the California Corporate Securities Act of 
1968, as amended, and the regulations thereunder).

     The opinions hereinafter expressed are subject to the following further 
qualifications:

          (i)     Our opinions are qualified by the effect of bankruptcy, 
insolvency, reorganization, arrangement, moratorium or other similar laws 
relating to or affecting the rights of creditors generally, including, 
without limitation, laws relating to fraudulent transfers or conveyances, 
preferences and equitable subordination;

          (ii)    Our opinions are qualified by the limitations imposed by 
general principles of equity upon the availability of equitable remedies or 
the enforcement of provisions of the Agreements; and the effect of judicial 
decisions which have held that certain provisions are unenforceable when 
their enforcement would violate the implied covenant of good faith and fair 
dealing, or would be commercially unreasonable, or where their breach is not 
material;

          (iii)   We express no opinion as to the enforceability of a 
requirement that provisions of the Agreements may only be waived in writing 
to the extent an oral agreement has been executed modifying provisions of the 
Agreements;

          (iv)    Our opinion is based upon current statutes, rules, 
regulations, cases and official interpretive opinions, and it covers certain 
items that are not directly or definitively addressed by such authorities;

          (v)     We express no opinion as to the effect of judicial 
decisions which may permit the introduction of extrinsic evidence to modify 
the terms or the interpretation of the Agreements;

          (vi)    We express no opinion as to the enforceability of 
provisions of the Agreements which purport to establish evidentiary standards 
or to make determinations conclusive;

          (vii)   We express no opinion as to the enforceability of 
provisions of the Agreements expressly or by implication waiving broadly or 
vaguely stated rights, or waiving rights granted by law where such waivers 
are against public policy;

          (viii)  We express no opinion as to the enforceability of 
provisions of the Agreements providing that rights or remedies are not 
exclusive, that every right or remedy is cumulative, or that the election of 
a particular remedy or remedies does not preclude recourse to one or more 
other remedies.

<PAGE>

January 27, 1999
Page 3

          (ix)    We express no opinion as to compliance with applicable 
antifraud statutes, rules or regulations of applicable state and federal laws 
concerning the issuance or sale of securities; and

          (x)     We express no opinion as to the enforceability of a 
provisions in the Registration Rights Agreement purporting to provide for 
indemnification and contribution under certain circumstances may be 
unenforceable.

     Based upon and subject to the foregoing, we are of the opinion that:

     (a)  The Company is a corporation duly organized and existing under the 
laws of the State of Delaware, and is in good standing under such laws.  The 
Company has the requisite corporate power to own and operate its properties 
and assets, and to carry on its business as presently conducted.  The Company 
is duly qualified to do business as foreign corporations in each state in 
which the failure to be so qualified would have a material adverse effect on 
the Company.

     (b)  The Company has the requisite corporate power to execute and 
deliver the Agreements, to sell and issue the Common Stock sold by it 
thereunder and to carry out and perform its obligations under the terms of 
the Agreements.

     (c)  All corporate action on the part of the Company, its directors and 
stockholders necessary for the authorization, execution, delivery and 
performance of the Agreements by the Company, the authorization, sale, 
issuance and delivery of the Common Stock and the performance of all of the 
Company's obligations under the Agreements has been taken.  The Agreements 
constitute valid and binding obligations of the Company enforceable in 
accordance with their terms.  The Common Stock sold by the Company in 
conformity with the terms of the Purchase Agreement constitute validly 
issued, fully paid and nonassessable securities of the Company.

     (d)  The execution, delivery and performance of and compliance with the 
Agreements, and the issuance of the Common Stock have not resulted and will 
not result in any material violation of, or material conflict with, or 
constitute a material default under (i) any of the agreements attached as 
exhibits to the Company's SEC Documents, (ii) the Company's Certificate of 
Incorporation or Bylaws or (iii) any statute, rule or regulation or any 
judgment or order known to us to which the Company is a party, or by which 
the Company is bound.

     (e)  To our knowledge, there are no actions, suits, proceedings or 
investigations pending against the Company or its properties before any court 
or governmental agency that, either in any case or in the aggregate, if 
determined adversely to the Company, would result in a material adverse 
change in the business or financial condition of the Company or in any 
material liability on the part of the Company, and none that questions the 
validity of the Agreements or any action taken or to be taken in connection 
therewith.

     (f)  To our knowledge, no material consent, approval or authorization of 
or designation, declaration or filing with, any governmental authority on the 
part of the Company is required in connection with the valid execution and 
delivery of the Agreements, or the offer, sale or issuance of the 

<PAGE>

January 27, 1999
Page 4

Common Stock sold by the Company, or the consummation of any other 
transaction contemplated by the Agreements, except the filings that are 
permitted to be made after the Closing that may be required under state and 
federal securities laws and rules of the National Association of Securities 
Dealers.

     (g)  The offer, sale and issuance of the Common Stock in conformity with 
the terms of the Purchase Agreement constitute transactions exempt from the 
registration requirements of Section 5 of the Securities Act and the 
securities laws of the State of California.

     We express no opinion as to matters governed by any laws other than the 
laws of the State of California, the General Corporation Law of the State of 
Delaware and the federal law of the United States of America.  We express no 
opinion as to whether the laws of any particular jurisdiction apply, and no 
opinion to the extent that the laws of any jurisdiction other than those 
identified above are applicable to the Agreements or the transactions 
contemplated thereby.

     This opinion is furnished to you pursuant to Section 4.7 of the Purchase 
Agreement and is solely for your benefit and may not be relied on by, nor may 
copies be delivered to, any other person without our prior written consent.  
We assume no obligation to inform you of any facts, circumstances, events or 
changes in the law that may hereafter be brought to our attention that may 
alter, affect or modify the opinion expressed herein.

                                   Sincerely,

                                   VENTURE LAW GROUP,
                                   A Professional Corporation


                                   /s/ Venture Law Group




<PAGE>
                                       

                               LJL BIOSYSTEMS, INC.


                          REGISTRATION RIGHTS AGREEMENT


                                 JANUARY 27, 1999

<PAGE>

                               LJL BIOSYSTEMS, INC.

                          REGISTRATION RIGHTS AGREEMENT

     This Registration Rights Agreement (the "AGREEMENT") is made as of the 
27th day of January, 1999, by and among LJL BioSystems, Inc., a Delaware 
corporation (the "COMPANY") and the investors listed on ATTACHMENT A hereto, 
each of which is herein referred to as an "INVESTOR."

                                   RECITALS

     The Company and the Investors have entered into a Common Stock Purchase 
Agreement (the "PURCHASE AGREEMENT") of even date herewith pursuant to which 
the Company has agreed to sell to the Investors and the Investors have agreed 
to purchase from the Company shares of the Company's Common Stock.

     ALL TERMS NOT OTHERWISE DEFINED HEREIN SHALL HAVE THE MEANINGS ASCRIBED 
IN THE PURCHASE AGREEMENT.

     A condition to the Investors' obligations under the Purchase Agreement 
is that the Company and the Investors enter into this Agreement in order to 
provide the Investors with certain rights to register the Securities acquired 
by the Investors subject to the Purchase Agreement.  The Company and the 
Investors each desire to induce the Investors to purchase the Securities 
pursuant to the Purchase Agreement by agreeing to the terms and conditions 
set forth herein.

                                  AGREEMENT

     The parties hereby agree as follows:

          1.   REGISTRATION RIGHTS. The Company and the Investors covenant 
and agree as follows:

               1.1  DEFINITIONS. For purposes of this Section 1 (terms 
defined in the singular shall apply to the plural form and vice-versa):

                    (a)  The terms "REGISTER," "REGISTERED," and 
"REGISTRATION" refer to a registration effected by preparing and filing a 
registration statement or similar document in compliance with the Securities 
Act of 1933, as amended (the "ACT"), and the declaration or ordering of 
effectiveness of such registration statement or document;

                    (b)  The term "REGISTRABLE SECURITIES" means (i) the 
shares of Common Stock issued or sold in connection with the Purchase 
Agreement (such shares of Common Stock are collectively referred to 
hereinafter as the "SHARES" or "STOCK"), and (ii) any other shares of Common 
Stock of the Company issued as (or issuable upon the conversion or exercise 
of any warrant, right or other security which is issued as) a dividend or 
other distribution with respect to, or in exchange for or in replacement of, 
the Stock, PROVIDED, that the foregoing 

<PAGE>

definition shall exclude in all cases any Registrable Securities sold by a 
person in a transaction in which his or her rights under this Agreement are 
not assigned.   Notwithstanding the foregoing, Common Stock or other 
securities shall only be treated as Registrable Securities if and so long as 
they have not (A) been sold to or through a broker or dealer or underwriter 
in a public distribution or a public securities transaction, or (B) been sold 
in a transaction exempt from the registration and prospectus delivery 
requirements of the Act under Section 4(1) thereof so that all transfer 
restrictions, and restrictive legends with respect thereto, if any, are 
removed upon the consummation of such sale or (C) with regard to any 
individual Holder, become eligible for sale in any three month period 
pursuant to Rule 144;

                    (c)  The number of shares of "REGISTRABLE SECURITIES THEN 
OUTSTANDING" shall be determined by the number of shares of Common Stock 
outstanding which are, and the number of shares of Common Stock issuable 
pursuant to then exercisable or convertible securities which are, Registrable 
Securities;

                    (d)  The term "HOLDER" means any person owning or having 
the right to acquire Registrable Securities or any assignee thereof in 
accordance with this Agreement;

                    (e)  The term "FORM S-3" means such form under the Act as 
in effect on the date hereof or any successor form under the Act; and

                    (f)  The term "SEC" means the Securities and Exchange 
Commission.

               1.2  FORM S-3 REGISTRATION. Subject to the terms and 
conditions of this Agreement, on or before the date that is six (6) months 
following the Closing (the "S-3 DATE"), the Company will file with the SEC a 
registration statement on Form S-3 and will use its best efforts to effect 
such registration and any related qualification or compliance with respect to 
all Registrable Securities owned by the Holders as soon as practicable 
thereafter.  If the Company does not file with the SEC a registration 
statement on Form S-3 by the date that is 30 days after the S-3 Date (the 
"S-3 Filing Deadline"), the Company agrees to pay the Purchasers, as 
liquidated damages, an amount equal to Two Hundred Fifty Thousand Dollars 
($250,000) on the day immediately after the S-3 Filing Deadline, provided 
however, that notwithstanding the above, the Company shall not pay any such 
damages if the Company defers filing a registration statement on Form S-3 
pursuant to subsection 1.2(b)(i) or subsection 1.2(b)(ii) below.  
Accordingly, the Company will:

                    (a)  promptly give written notice of the registration, 
and any related qualification or compliance, to all Holders;

                    (b)  as soon as practicable, effect such registration and 
all such qualifications and compliances as may be necessary and as would 
permit or facilitate the sale and distribution of all of the Holders' 
Registrable Securities; provided, however, that the Company shall not be 
obligated to effect any such registration, qualification or compliance, 
pursuant to this Section 1.2 if (i) the Company shall furnish to the Holders 
a certificate signed by the President of the Company stating that in the good 
faith judgment of the Board of Directors of the Company, it 

                                       2
<PAGE>

would be seriously detrimental to the Company and its stockholders for such 
Form S-3 Registration to be effected at such time, in which event the Company 
shall have the right to defer the filing of the Form S-3 registration 
statement for a reasonable period of time, which shall not exceed thirty (30) 
days after the S-3 Filing Deadline, under this Section 1.2 or (ii) if Form 
S-3 is not available for such offering by the Holder(s), provided, however, 
that if Form S-3 is not available, Company shall file the Form S-3 
registration statement once it is available; and

                    (c)  any and all expenses incurred in connection with a 
registration requested pursuant to this Section 1.2 shall be borne by the 
Company, including all registration, filing, qualification, printers' and 
accounting fees but excluding any underwriters' discounts or commissions and 
any fees and disbursements of any counsel for the selling Holders (such fees 
or discounts, if any, to be borne pro rata by the Holders participating in 
the registration).

               1.3  OBLIGATIONS OF THE COMPANY. Whenever required under this 
Section 1 to effect the registration of any Registrable Securities, the 
Company shall, as expeditiously as reasonably possible:

                    (a)  Prepare and file with the SEC a registration 
statement with respect to such Registrable Securities and use its best 
efforts to cause such registration statement to become effective and to keep 
such registration statement effective for a period of three (3) years after 
the date on which the registration statement is declared effective or such 
shorter period:  (i) when all of the Registrable Securities covered by the 
registration statement are sold; or (ii) when Rule 144(k) is available to 
each of the Investors.

                    (b)  Prepare and file with the SEC such amendments and 
supplements to such registration statement and the prospectus used in 
connection with such registration statement as may be necessary to comply 
with the provisions of the Act with respect to the disposition of all 
securities covered by such registration statement.

                    (c)  Furnish to the Holders such numbers of copies of a 
prospectus, including a preliminary prospectus, in conformity with the 
requirements of the Act, and such other documents as they may reasonably 
request in order to facilitate the disposition of Registrable Securities 
owned by them.

                    (d)  Use its best efforts to register and qualify the 
securities covered by such registration statement under such other securities 
or blue sky laws of such jurisdictions as shall be reasonably requested by 
the Holders, provided that the Company shall not be required in connection 
therewith or as a condition thereto to qualify to do business or to file a 
general consent to service of process in any such states or jurisdictions.

                    (e)  Notify each Holder of Registrable Securities covered 
by such registration statement at any time when a prospectus relating thereto 
is required to be delivered under the Act of the happening of any event as a 
result of which the prospectus included in such registration statement, as 
then in effect, includes an untrue statement of a material fact or omits to 
state a material fact required to be stated therein or necessary to make 

                                       3
<PAGE>

the statements therein not misleading in the light of the circumstances then 
existing.  In such circumstance, the Company will use reasonable commercial 
efforts to promptly update such prospectus to correct such untrue statement 
or disclose the necessary material facts within the period of time the 
Company may delay sales under Section 1.4(a)(iii) below.
                    

               1.4  RESTRICTIONS ON AND PROCEDURE FOR SALES PURSUANT TO A
                    REGISTRATION STATEMENT.

                    (a)  Each Holder agrees to the following:

                         (i)  NOTICE TO COMPANY.  If any Holder shall propose 
to sell any Shares, the Holder shall notify the Company of its intent to do 
so on or before one (1) business day prior to the date of such sale (the 
"Notice of Sale"), and the provision of the Notice of Sale to the Company 
shall conclusively be deemed to establish an agreement by such Holder to 
comply with the registration provisions herein described.  The Notice of Sale 
shall be deemed to constitute a representation that any information 
previously supplied by such Holder is accurate as of the date of such Notice 
of Sale.

                         (ii) NOTICE OF SALE.  The Notice of Sale in 
substantially the form attached as ATTACHMENT B shall be given in accordance 
with the provisions of Section 2.5 hereof.  However, the Holder may give the 
Notice of Sale orally by telephoning the current Chief Financial Officer at 
the Company at (408) 448-0542.  An oral Notice of Sale shall be deemed to 
have been received only at such time as the Selling Holder speaks directly 
with the current Chief Financial Officer.  In addition, an oral Notice of 
Sale shall only be deemed effective if it is followed by a written Notice of 
Sale received by the Company by personal delivery or facsimile within 
twenty-four (24) hours after giving the oral Notice of Sale.

                        (iii) DELAY OF SALE.  The Company may refuse to 
permit the Holder to resell any Shares for a period of time not to exceed 
forty five (45) days; provided, however, that in order to exercise this 
right, the Company must deliver a certificate in writing to the Holder to the 
effect that the registration statement in its then current form contains an 
untrue statement of material fact or omits to state a material fact necessary 
in order to make the statements made therein, in light of the circumstances 
under which they were made, not misleading.  During any suspension period as 
contemplated by this Section 1.4 (a)(iii), of which there shall be no more 
than three (3) in any twelve (12) month period, the Company will not allow 
any of its officers or directors to buy or sell shares of the Company's 
securities.

                    (b)  REPRESENTATIONS OF HOLDERS.  Each Holder hereby 
represents to and covenants with the Company that, during the period in which 
any registration statement effected pursuant to Section 1.2 remains 
effective, such Holder will:

                         (i)   not engage in any stabilization activity in 
connection with any of the Company's securities;

                                       4
<PAGE>

                         (ii)  cause to be furnished to any purchaser of the 
Shares and to the broker-dealer,  if any, through whom Shares may be offered, 
a copy of the Prospectus; and

                         (iii) not bid for or purchase any securities of the 
Company or any rights to acquire the Company's securities, or attempt to 
induce any person to purchase any of the Company's securities or any rights 
to acquire the Company's securities, in each case, other than as permitted 
under the Securities Exchange Act of 1934, as amended ("Exchange Act").

                    (c)  INFORMATION FOR USE IN REGISTRATION STATEMENT.  Each 
Holder represents and warrants to the Company that such Holder has completed 
the information requested by the Selling Holder's Questionnaire attached as 
ATTACHMENT C hereto (the "Questionnaire"), and further represents and 
warrants to the Company that all information provided by such Holder in the 
Questionnaire is true, accurate and complete.  Each Holder understands that 
the written information in the Questionnaire and all written representations 
made in this Agreement are being provided to the Company specifically for use 
in, or in connection with, the registration statement and the Prospectus, and 
has executed this Agreement with such knowledge.

               1.5  FURNISH INFORMATION.  It shall be a condition precedent 
to the obligations of the Company to take any action pursuant to this Section 
1 with respect to the Registrable Securities of any selling Holder that such 
Holder shall furnish to the Company such information regarding itself, the 
Registrable Securities held by it, and the intended method of disposition of 
such securities as shall be required to effect the registration of such 
Holder's Registrable Securities.

               1.6  DELAY OF REGISTRATION. No Holder shall have any right to 
obtain or seek an injunction restraining or otherwise delaying any such 
registration as the result of any dispute that might arise with respect to 
the interpretation or implementation of this Section 1.

               1.7  INDEMNIFICATION. In the event any Registrable Securities 
are included in a registration statement under this Section 1:

                    (a)  To the extent permitted by law, the Company will 
indemnify and hold harmless each Holder, any underwriter (as defined in the 
Act) for such Holder and each person, if any, who controls such Holder or 
underwriter within the meaning of the Act or the Exchange Act, against any 
losses, claims, damages, or liabilities (joint or several) to which they may 
become subject under the Act, the Exchange Act or other federal or state law, 
insofar as such losses, claims, damages, or liabilities (or actions in 
respect thereof) arise out of or are based upon any of the following 
statements, omissions or violations (collectively a "VIOLATION"):  (i) any 
untrue statement or alleged untrue statement of a material fact contained in 
such registration statement, including any preliminary prospectus or final 
prospectus contained therein or any amendments or supplements thereto, (ii) 
the omission or alleged omission to state therein a material fact required to 
be stated therein, or necessary to make the statements therein not 
misleading, or (iii) any violation or alleged violation by the Company of the 
Act, the 

                                       5
<PAGE>

Exchange Act, any state securities law or any rule or regulation promulgated 
under the Act, the Exchange Act or any state securities law; and the Company 
will pay to each such Holder, underwriter or controlling person, as incurred, 
any legal or other expenses reasonably incurred by them in connection with 
investigating or defending any such loss, claim, damage, liability, or 
action; provided, however, that the indemnity agreement contained in this 
subsection 1.7(a) shall not apply to amounts paid in settlement of any such 
loss, claim, damage, liability, or action if such settlement is effected 
without the consent of the Company (which consent shall not be unreasonably 
withheld), nor shall the Company be liable in any such case for any such 
loss, claim, damage, liability, or action to the extent that it arises out of 
or is based upon a Violation which occurs in reliance upon and in conformity 
with written information furnished expressly for use in connection with such 
registration by any such Holder, underwriter or controlling person.

                    (b)  To the extent permitted by law, each selling Holder 
will indemnify and hold harmless the Company, each of its directors, each of 
its officers who has signed the registration statement, each person, if any, 
who controls the Company within the meaning of the Act, any underwriter, any 
other Holder selling securities in such registration statement and any 
controlling person of any such underwriter or other Holder, against any 
losses, claims, damages, or liabilities (joint or several) to which any of 
the foregoing persons may become subject, under the Act, the Exchange Act or 
other federal or state law, insofar as such losses, claims, damages, or 
liabilities (or actions in respect thereto) arise out of or are based upon 
any Violation, in each case to the extent (and only to the extent) that such 
Violation occurs in reliance upon and in conformity with written information 
furnished by such Holder expressly for use in connection with such 
registration; and each such Holder will pay, as incurred, any legal or other 
expenses reasonably incurred by any person intended to be indemnified 
pursuant to this subsection 1.7(b), in connection with investigating or 
defending any such loss, claim, damage, liability, or action; provided, 
however, that the indemnity agreement contained in this subsection 1.7(b) 
shall not apply to amounts paid in settlement of any such loss, claim, 
damage, liability or action if such settlement is effected without the 
consent of the Holder, which consent shall not be unreasonably withheld; 
provided, that, in no event shall any indemnity under this subsection 1.7(b) 
exceed the net proceeds from the offering received by such Holder, except in 
the case of willful fraud by such Holder.

                    (c)  Promptly after receipt by an indemnified party under 
this Section 1.7 of notice of the commencement of any action (including any 
governmental action), such indemnified party will, if a claim in respect 
thereof is to be made against any indemnifying party under this Section 1.7, 
deliver to the indemnifying party a written notice of the commencement 
thereof and the indemnifying party shall have the right to participate in, 
and, to the extent the indemnifying party so desires, jointly with any other 
indemnifying party similarly noticed, to assume the defense thereof with 
counsel mutually satisfactory to the parties; provided, however, that an 
indemnified party (together with all other indemnified parties which may be 
represented without conflict by one counsel) shall have the right to retain 
one separate counsel, with the reasonable fees and expenses to be paid by the 
indemnifying party, if representation of such indemnified party by the 
counsel retained by the indemnifying party would be inappropriate due to 
actual or potential differing interests between such indemnified party and 
any other party represented by such counsel in such proceeding.  The failure 
to deliver written notice to the 

                                      6
<PAGE>

indemnifying party within a reasonable time of the commencement of any such 
action, if prejudicial to its ability to defend such action, shall relieve 
such indemnifying party of any liability to the indemnified party under this 
Section 1.7, but the omission so to deliver written notice to the 
indemnifying party will not relieve it of any liability that it may have to 
any indemnified party otherwise than under this Section 1.7.

                    (d)  If the indemnification provided for in this Section 
1.7 is held by a court of competent jurisdiction to be unavailable to an 
indemnified party with respect to any loss, liability, claim, damage, or 
expense referred to therein, then the indemnifying party, in lieu of 
indemnifying such indemnified party hereunder, shall contribute to the amount 
paid or payable by such indemnified party as a result of such loss, 
liability, claim, damage, or expense in such proportion as is appropriate to 
reflect the relative fault of the indemnifying party on the one hand and of 
the indemnified party on the other in connection with the statements or 
omissions that resulted in such loss, liability, claim, damage, or expense as 
well as any other relevant equitable considerations; provided, that, in no 
event shall any contribution by a Holder under this Subsection 1.7(d) exceed 
the net proceeds from the offering received by such Holder, except in the 
case of willful fraud by such Holder.  The relative fault of the indemnifying 
party and of the indemnified party shall be determined by reference to, among 
other things, whether the untrue or alleged untrue statement of a material 
fact or the omission to state a material fact relates to information supplied 
by the indemnifying party or by the indemnified party and the parties' 
relative intent, knowledge, access to information, and opportunity to correct 
or prevent such statement or omission.

                    (e)  The obligations of the Company and Holders under 
this Section 1.7 shall survive the completion of any offering of Registrable 
Securities in a registration statement under this Section 1.

               1.8  REPORTS UNDER SECURITIES EXCHANGE ACT OF 1934. With a 
view to making available to the Holders the benefits of Rule 144 and any 
other rule or regulation of the SEC that may at any time permit a Holder to 
sell securities of the Company to the public without registration or pursuant 
to a registration on Form S-3, the Company agrees to:

                    (a)  make and keep public information available, as those 
terms are understood and defined in Rule 144, so long as the Company remains 
subject to the periodic reporting requirements under Sections 13 or 15(d) of 
the Exchange Act;

                    (b)  take such action, including the voluntary 
registration of its Common Stock under Section 12 of the Exchange Act, as is 
necessary to enable the Holders to utilize Form S-3 for the sale of their 
Registrable Securities, such action to be taken as soon as practicable after 
the end of the fiscal year in which the first registration statement filed by 
the Company for the offering of its securities to the general public is 
declared effective;

                    (c)  file with the SEC in a timely manner all reports and 
other documents required of the Company under the Act and the Exchange Act; 
and

                                      7
<PAGE>

                    (d)  furnish to any Holder, so long as the Holder owns 
any Registrable Securities, forthwith upon request (i) a written statement by 
the Company that it has complied with the reporting requirements of the 
Exchange Act and the rules and regulations promulgated thereunder, or that it 
qualifies as a registrant whose securities may be resold pursuant to Form 
S-3, (ii) a copy of the most recent annual or quarterly report of the Company 
and such other reports and documents so filed by the Company, and (iii) such 
other information as may be reasonably requested in availing any Holder of 
any rule or regulation of the SEC which permits the selling of any such 
securities without registration or pursuant to such form.

          1.9  ASSIGNMENT OF REGISTRATION RIGHTS. The rights to cause the 
Company to register Registrable Securities pursuant to this Section 1 may be 
assigned (but only with all related obligations) by a Holder to a transferee 
or assignee of at least 150,000 shares of such securities, provided the 
Company is, within a reasonable time after such transfer, furnished with 
written notice of the name and address of such transferee or assignee and the 
securities with respect to which such registration rights are being assigned, 
which information shall amend Attachment A hereto; and provided, further, 
that such assignment shall be effective only if immediately following such 
transfer the further disposition of such securities by the transferee or 
assignee is restricted under the Act.  For the purposes of determining the 
number of shares of Registrable Securities held by a transferee or assignee, 
the holdings of transferees and assignees of a partnership who are partners 
or retired partners of such partnership (including spouses and ancestors, 
lineal descendants and siblings of such partners or spouses who acquire 
Registrable Securities by gift, will or intestate succession) shall be 
aggregated together and with the partnership; provided that all assignees and 
transferees who would not qualify individually for assignment of registration 
rights shall have a single attorney-in-fact for the purpose of exercising any 
rights, receiving notices or taking any action under Section 1.

          2.   MISCELLANEOUS.

               2.1  SUCCESSORS AND ASSIGNS. Except as otherwise provided 
herein, the terms and conditions of this Agreement shall inure to the benefit 
of and be binding upon the respective successors and assigns of the parties.  
Nothing in this Agreement, express or implied, is intended to confer upon any 
party other than the parties hereto or their respective successors and 
assigns any rights, remedies, obligations, or liabilities under or by reason 
of this Agreement, except as expressly provided in this Agreement.

               2.2  GOVERNING LAW. This Agreement and all acts and 
transactions pursuant hereto shall be governed, construed and interpreted in 
accordance with the laws of the State of California, without giving effect to 
principles of conflicts of laws.

               2.3  COUNTERPARTS. This Agreement may be executed in two (2) 
or more counterparts, each of which shall be deemed an original, but all of 
which together shall constitute one and the same instrument.

               2.4  TITLES AND SUBTITLES. The titles and subtitles used in 
this Agreement are used for convenience only and are not to be considered in 
construing or interpreting this Agreement.

                                      8
<PAGE>

               2.5  NOTICES. Unless otherwise provided herein, any notice 
required or permitted by this Agreement shall be in writing and shall be 
deemed sufficient upon delivery, when delivered personally or by overnight 
courier and addressed to a Holder to be notified at such party's address as 
set forth on ATTACHMENT A hereto or to the Company at its address on its 
signature page hereto, or as subsequently modified by written notice. In the 
event that any date provided for in this Agreement falls on a Saturday, 
Sunday or legal holiday, such date shall be deemed extended to the next 
business day. Notwithstanding the foregoing, any notice delivered pursuant to 
Section 1.3(e) or Section 1.4 hereto must be made by personal delivery or 
confirmed facsimile transmission.

               2.6  EXPENSES. If any action at law or in equity is necessary 
to enforce or interpret the terms of this Agreement, the prevailing party 
shall be entitled to reasonable attorneys' fees, costs and necessary 
disbursements in addition to any other relief to which such party may be 
entitled.

               2.7  AMENDMENTS AND WAIVERS. Any term of this Agreement may be 
amended and the observance of any term of this Agreement may be waived 
(either generally or in a particular instance and either retroactively or 
prospectively), only with the written consent of the Company and the holders 
of a majority of the Registrable Securities then outstanding.  Any amendment 
or waiver effected in accordance with this paragraph shall be binding upon 
each holder of any Registrable Securities then outstanding, each future 
holder of all such Registrable Securities, and the Company.

               2.8  SEVERABILITY.  If one or more provisions of this 
Agreement are held to be unenforceable under applicable law, the parties 
agree to renegotiate such provision in good faith.  In the event that the 
parties cannot reach a mutually agreeable and enforceable replacement for 
such provision, then (x) such provision shall be excluded from this 
Agreement, (y) the balance of the Agreement shall be interpreted as if such 
provision were so excluded and (z) the balance of the Agreement shall be 
enforceable in accordance with its terms.

               2.9  ENTIRE AGREEMENT.  This Agreement, and the documents 
referred to herein (with the exception of the registration statement) 
constitute the entire agreement between the parties hereto pertaining to the 
subject matter hereof, and any and all other written or oral agreements 
existing between the parties hereto are expressly canceled.
               
                                       
                            [SIGNATURE PAGES FOLLOW]

                                      9
<PAGE>

     The parties have executed this Registration Rights Agreement as of the 
date first written above.

                                        COMPANY:

                                        LJL BIOSYSTEMS, INC.


                                        By: /s/ Lev J. Leytes
                                            --------------------------------
                                            Name:    Lev J. Leytes
                                                     -----------------------
                                            Title:   President
                                                     -----------------------
                                            Address: 405 Tasman Drive
                                                     -----------------------
                                                     Sunnyvale, CA  94089
                                                     -----------------------

<PAGE>


     The parties have executed this Registration Rights Agreement as of the 
date first written above.

                                        THE BAY CITY CAPITAL FUND I, L.P.

                                        By:  BAY CITY CAPITAL MANAGEMENT LLC
                                        Its: General Partner


                                        By:  /s/ Roger H. Salquist
                                            --------------------------------
                                            Name:    Roger H. Salquist
                                                     -----------------------
                                            Title:   Managing Partner
                                                     -----------------------

<PAGE>


     The parties have executed this Registration Rights Agreement as of the 
date first written above.

                                        SKYLINE VENTURE PARTNERS, L.P.


                                        By:  Skyline Venture Management LLC
                                        Its: General Partner


                                        By:  /s/ John Freund
                                            --------------------------------
                                            John Freund
                                            Managing Director

                                      2
<PAGE>


     The parties have executed this Registration Rights Agreement as of the 
date first written above.

                                        THE KAUFMANN FUND, INC.


                                        By:  /s/ Hans P. Utsch
                                            --------------------------------
                                            Hans P. Utsch
                                            President

                                      3
<PAGE>


                                 ATTACHMENT A

                                  INVESTORS
<TABLE>
<CAPTION>
                                                       No. of Shares
Name/Address                                           of Common Stock
- ------------                                           ---------------
<S>                                                    <C>
The Bay City Capital Fund I, L.P.                          857,143
750 Battery Street, Suite 600
San Francisco, CA  94111

The Kaufmann Fund, Inc.                                    857,143
140 E. 45th Street, 43rd Floor
New York, NY  10017

Skyline Venture Partners, L.P.                             285,714
525 University Avenue, Suite 701
Palo Alto, CA  94301
</TABLE>

<PAGE>

                                       
                                  ATTACHMENT B

                              LJL BIOSYSTEMS, INC.

                                 NOTICE OF SALE



     Pursuant to the Registration Rights Agreement dated as of __________, 
1999 among LJL BioSystems, Inc. (the "Company"), the undersigned and certain 
stockholders of the Company, the undersigned hereby gives notice to the 
Company of the undersigned's intent to sell _______ shares of the Company's 
Common Stock registered pursuant to the registration statement on 
(File No.__________).



Dated:   ______________, 199__          By:___________________________________
                                                        (signature)


                                        Name:_________________________________
                                                          (print)


                                        Title:________________________________
                                                      (if applicable)











     [NOTE: THIS NOTICE OF SALE MUST BE COMPLETED AND DELIVERED (VIA PERSONAL
     DELIVERY OR FACSIMILE) TO THE CHIEF FINANCIAL OFFICER OF THE COMPANY ON OR
     BEFORE ONE (1) BUSINESS DAY BEFORE THE DATE OF SALE OF THE SHARES OF THE
     COMPANY'S COMMON STOCK REGISTERED PURSUANT TO THE REGISTRATION STATEMENT.]

<PAGE>
                                       

                                  ATTACHMENT C

                              LJL BIOSYSTEMS, INC.

                      SELLING STOCKHOLDER'S QUESTIONNAIRE


     In connection with the LJL BioSystems, Inc. (the "Company") Registration 
Statement (File No.__________) registering certain shares of the Company's 
Common Stock, the undersigned represents and warrants that the information 
set forth below is true, accurate and complete:

     1.  As of the date hereof, the undersigned beneficially owns ______ 
shares of the Company's Common Stock.

     2.  Except as described below, the undersigned has not had a material 
relationship with the Company or any of its predecessors or affiliates within 
the last three years.  

     The term "material relationship" has not been defined by the Securities 
and Exchange Commission (the "SEC").  However, the SEC has indicated that it 
will probably construe as a "material relationship" any relationship which 
tends to prevent arms length bargaining in dealings with a company, whether 
arising from a close business connection or family relationship, a 
relationship of control or otherwise.  It seems prudent, therefore, to 
consider that the undersigned would have such a relationship, for example, 
with any organization of which the undersigned is an officer, director, 
trustee or partner or in which the undersigned owns, directly or indirectly, 
ten percent (10%) or more of the outstanding voting stock, or in which the 
undersigned has some other substantial interest, and with any person or 
organization with whom the undersigned has, or with whom any relative or 
spouse (or any other person or organization as to which the undersigned has 
any of the foregoing other relationships) has, a contractual relationship.

     If applicable, please describe the material relationship with the Company:
_______________________________________________________________________________

_______________________________________________________________________________

_______________________________________________________________________________

_______________________________________________________________________________
 
                                        Holder

                                        _______________________________________
                                        Name: _________________________________
                                        Title:_________________________________


<PAGE>
                                       
FOR IMMEDIATE RELEASE

CONTACTS:

LJL BIOSYSTEMS, INC.:         MEDIA RELATIONS:         INVESTOR RELATIONS:

Larry Tannenbaum              Friestedt International       Financial Relations
CFO and Senior Vice President Susanne Friestedt             Board
(408) 548-0542                (619) 223-8844
[email protected]        [email protected]       Lise Needham (general
                                                            info)
                                                       Kate Rajeck (analyst
                                                            contact)
                                                       Scott Marx (media)
                                                       (415) 986-1591
                                                       [email protected]

                                       
              LJL BIOSYSTEMS RAISES $7.0 MILLION PRIVATE PLACEMENT
                 JOHN DIEKMAN, PH.D., JOINS BOARD OF DIRECTORS


SUNNYVALE, CA, JANUARY 27, 1999 -- LJL BioSystems, Inc. (Nasdaq: LJLB), a 
leading manufacturer of High Throughput Screening (HTS) products for 
accelerated drug discovery today announced it raised $7 million in a private 
placement of 2 million shares of unregistered Common Stock.  

Bay City Capital, a leading investor in the life sciences industry and The 
Kaufmann Fund, an emerging growth company mutual fund co-lead this 
investment. As part of this transaction, John Diekman, a Managing Director of 
Bay City Capital, will join LJL's Board of Directors.

"Bay City and the Kaufmann Fund are well respected institutional investors in 
healthcare today. We look forward to their contributions as we continue to 
build value for LJL shareholders. The capital infusion from this financing 
will support an expanded effort to grow LJL's installed base of HTS systems 
at pharmaceutical and biotechnology companies around the world. The new 
funding will also help us accelerate development and commercialization of new 
consumable products, such as assay kits, plates, and reagents, an important 
element of our business strategy," said Lev Leytes, LJL's President and Chief 
Executive Officer.
 
"The addition of John Diekman to our Board of Directors provides us with 
tremendous industry experience. John has worked closely with global 
pharmaceutical leaders to commercialize technologies that are transforming 
the industry.  Furthermore, John has extensive experience in drug discovery 
as well as in directing the strategic growth of several successful 
companies," Leytes added.

Dr. Diekman has more than 20 years of experience in drug discovery and 
pharmaceutical organizations including roles as CEO or President at 
Affymetrix, Affymax, Monoclonal Antibodies, Salutar and Zoecon.  He is 
currently a director of several public and private companies and is on the 
Board of Trustees of the Scripps Research Institute in La Jolla. 

<PAGE>

"As Bay City Capital worked with LJL to put this transaction together, we 
became convinced that LJL is implementing an intelligent and powerful 
approach to a truly significant market opportunity," said Diekman. " We look 
forward to contributing as an investor and board member to LJL's success."

Skip Klein, health care analyst for The Kaufmann Fund said, "The potential in 
the High Throughput Screening market is significant as the explosion brought 
on by genomics and combinatorial chemistry makes HTS crucial to every 
pharmaceutical and biotechnology company.  I first heard about LJL from 
satisfied customers as well as from competitors.  LJL's customers are excited 
and supportive of their distributive approach to HTS.  I believe they have a 
great opportunity as their installed equipment base grows and they further 
expand their consumables offering.  Clearly, the gold rush is on, and LJL is 
in an unique provider of picks and shovels."

The securities sold in this private placement have not been registered in the 
United States under the Securities Act of 1933. The company will register the 
shares at a future date.  The company offered the shares directly to 
investors and used Hambrecht & Quist as its financial advisor.  LJL now has 
approximately 12.5 million shares of Common Stock outstanding.



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