VARIAGENICS INC
S-8, EX-99.3, 2000-10-18
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                                                                    EXHIBIT 99.3


                  FORM OF NON-QUALIFIED STOCK OPTION AGREEMENT

                                VARIAGENICS, INC.



         AGREEMENT made this GRANT DATE, between Variagenics, Inc. (the
"Company"), a Delaware corporation having a principal place of business in
Cambridge, Massachusetts and NAME & ADDRESS (the "Optionee").

         WHEREAS, the Company desires to grant to the Optionee an Option to
purchase shares of its common stock, $.01 par value (the "Shares"), under and
for the purposes of the Company's Amended 1997 Employee, Director and Consultant
Stock Option Plan (the "Plan");

         WHEREAS, the Company and the Optionee understand and agree that any
terms used and not defined herein have the same meanings as in the Plan;

         WHEREAS, the Company and the Optionee each intend that the Option
granted herein shall be a Non-Qualified Stock Option.

         NOW, THEREFORE, in consideration of the mutual covenants hereinafter
set forth and for other good and valuable consideration, the parties hereto
agree as follows:

         1.       GRANT OF OPTION.

                  The Company hereby grants to the Optionee the right and option
to purchase all or any part of an aggregate of NUMBER Shares, on the terms and
conditions and subject to all of the limitations set forth herein and in the
Plan, which is incorporated herein by reference. The Optionee acknowledges
receipt of a copy of the Plan.

         2.       PURCHASE PRICE.

                  The purchase price of the Shares covered by the Option shall
be PRICE per Share, subject to adjustment, as provided in the Plan, in the event
of a stock split, reverse stock split or other events affecting the holders of
Shares. Payment shall be made in accordance with paragraph 7 of the Plan.

         3.       EXERCISE OF OPTION.

                  Subject to the terms and conditions set forth in this
Agreement and the Plan, the Option granted hereby shall become exercisable as
follows:

    ONE YEAR ANNIVERSARY                          NUMBER
    On the first day of each month thereafter     An additional NUMBER of shares
<PAGE>

         The foregoing rights are cumulative and are subject to the other terms
and conditions of this Agreement and the Plan.

         4.       TERM OF OPTION.

         The Option shall terminate ten (10) years from the date of this
Agreement, but shall be subject to earlier termination as provided herein or in
the Plan.

                  If the Optionee ceases to be an employee, director or
consultant of the Company or of an Affiliate (for any reason other than the
death or Disability of the Optionee or termination of the Optionee for "cause"
as defined in the Plan), the Option may be exercised, if it has not previously
terminated, within three (3) months after the date the Optionee ceases to be an
employee, director or consultant of the Company or an Affiliate, or within the
originally prescribed term of the Option, whichever is earlier, but may not be
exercised thereafter. In such event, the Option shall be exercisable only to the
extent that the Option has become exercisable and is in effect at the date of
such cessation of employment, consultancy or directorship.

                  Notwithstanding the foregoing, in the event of the Optionee's
death within three (3) months after the termination of employment, directorship
or consultancy, the Optionee's legal representatives and/or any person or
persons who acquired the Optionee's rights to the Option by will or by the laws
of descent and distribution may exercise the Option within one (1) year after
the date of the Optionee's death, but in no event after the date of expiration
of the term of the Option.

                  In the event the Optionee's employment, directorship or
consultancy is terminated by the Company for "cause" as defined in the Plan, the
Optionee's right to exercise any unexercised portion of this Option shall cease
forthwith, and this Option shall thereupon terminate. Notwithstanding anything
herein to the contrary, if subsequent to the Optionee's termination as an
employee, director or consultant but prior to the exercise of the Option, the
Board of Directors of the Company determines that, either prior or subsequent to
the Optionee's termination, the Optionee engaged in conduct which would
constitute "cause," then the Optionee shall forthwith cease to have any right to
exercise the Option and this Option shall thereupon terminate.

                  In the event of the Disability of the Optionee, as determined
in accordance with the Plan, the Option shall be exercisable within one (1) year
after the date of such Disability or, if earlier, the term originally prescribed
by the Option. In such event, the Option shall be exercisable:

                  (a)      to the extent exercisable but not exercised as of the
                           date of Disability; and

                  (b)      in the event rights to exercise the Option accrue
                           periodically, to the extent of a pro rata portion of
                           any additional rights as would have accrued had the
                           Optionee not become Disabled prior to the end of the
                           accrual period which next ends following


                                      -2-
<PAGE>

                           the date of Disability. The proration shall be based
                           upon the number of days of the accrual period prior
                           to the date of Disability.

                  In the event of the death of the Optionee while an employee,
consultant or director of the Company or of an Affiliate, the Option shall be
exercisable by the Optionee's Survivors. In such event, the Option must be
exercised, if at all, within one (1) year after the date of death of the
Optionee or, if earlier, within the originally prescribed term of the Option. In
such event, the Option shall be exercisable:

                  (x)      to the extent exercisable but not exercised as of the
                           date of death; and

                  (y)      in the event rights to exercise the Option accrue
                           periodically, to the extent of a pro rata portion of
                           any additional rights as would have accrued had the
                           Optionee not died prior to the end of the accrual
                           period which next ends following the date of death.
                           The proration shall be based upon the number of days
                           during the accrual period prior to the Optionee's
                           death.

         5.       METHOD OF EXERCISING OPTION.

         Subject to the terms and conditions of this Agreement, the Option may
be exercised by written notice to the Company, at the principal executive office
of the Company. Such notice shall state the election to exercise the Option and
the number of Shares in respect of which it is being exercised, shall be signed
by the person or persons so exercising the Option, and shall be in substantially
the form attached hereto. Payment of the purchase price for such Shares shall be
made in accordance with Paragraph 7 of the Plan. The Company shall deliver a
certificate or certificates representing such Shares as soon as practicable
after the notice shall be received, provided, however, that the Company may
delay issuance of such Shares until completion of any action or obtaining of any
consent, which the Company deems necessary under any applicable law (including,
without limitation, state securities or "blue sky" laws). The certificate or
certificates for the Shares as to which the Option shall have been so exercised
shall be registered in the name of the person or persons so exercising the
Option (or, if the Option shall be exercised by Optionee and if Optionee shall
so request in the notice exercising the Option, shall be registered in the name
of the Optionee and another person jointly, with right of survivorship) and
shall be delivered as provided above to or upon the written order of the person
or persons exercising the Option. In the event the Option shall be exercised,
pursuant to Section 4 hereof, by any person or persons other than the Optionee,
such notice shall be accompanied by appropriate proof of the right of such
person or persons to exercise the Option. All Shares that shall be purchased
upon the exercise of the Option as provided herein shall be fully paid and
nonassessable.

6.       PARTIAL EXERCISE.

         Exercise of this Option to the extent above stated may be made in part
at any time and from time to time within the above limits, except that no
fractional share shall be issued pursuant to this Option.


                                      -3-
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         7.       NON-ASSIGNABILITY.

                  The Option shall not be transferable by the Optionee otherwise
than by will or by the laws of descent and distribution or pursuant to a
qualified domestic relations order as defined by the Code or Title I of the
Employee Retirement Income Security Act or the rules thereunder. Except as
provided in the previous sentence, the Option shall be exercisable, during the
Optionee's lifetime, only by the Optionee and shall not be assigned, pledged or
hypothecated in any way (whether by operation of law or otherwise) and shall not
be subject to execution, attachment or similar process. Any attempted transfer,
assignment, pledge, hypothecation or other disposition of the Option or of any
rights granted hereunder contrary to the provisions of this Section 7, or the
levy of any attachment or similar process upon the Option or such rights, shall
be null and void.

         8.       NO RIGHTS AS STOCKHOLDER UNTIL EXERCISE.

         The Optionee shall have no rights as a stockholder with respect to
Shares subject to this Agreement until registration of the Shares in the
Company's share register in the name of the Optionee. Except as is expressly
provided in the Plan with respect to certain changes in the capitalization of
the Company, no adjustment shall be made for dividends or similar rights for
which the record date is prior to the date of such registration.

         9.       CAPITAL CHANGES AND BUSINESS SUCCESSIONS.

         The Plan contains provisions covering the treatment of Options in a
number of contingencies such as stock splits and mergers. Provisions in the Plan
for adjustment with respect to stock subject to Options and the related
provisions with respect to successors to the business of the Company are hereby
made applicable hereunder and are incorporated herein by reference.

         10.      TAXES AND WITHHOLDING.

         The Optionee acknowledges that upon exercise of the Option the Optionee
will be deemed to have taxable income measured by the difference between the
then fair market value of the Shares received upon exercise and the price paid
for such Shares pursuant to this Agreement (the "Taxable Income"). The Optionee
acknowledges that any income or other taxes due from him or her with respect to
this Option or the Shares issuable pursuant to this Option shall be the
Optionee's responsibility.

         If the Company in its discretion determines that it is obligated to
withhold income or other taxes with respect to the exercise of the Option, the
Optionee hereby agrees that the Company may withhold from the Optionee's
remuneration, if any, the minimum statutory amount of federal, state and local
withholding attributable to such amount that is considered compensation
includable in such person's gross income. At the Company's discretion, the
amount required to be withheld may be withheld in cash from such remuneration,
or in kind from the common stock otherwise deliverable to the Optionee on
exercise of the Option, provided, however, that with respect to persons subject
to Section 16 of the


                                      -4-
<PAGE>

Securities Exchange Act of 1934 (the "1934 Act"), any such withholding
arrangement shall be in compliance with any applicable provisions of Rule 16b-3
promulgated under Section 16 of the 1934 Act. The Optionee further agrees that,
if the Company does not withhold an amount from the Optionee's remuneration
sufficient to satisfy the Company's income tax withholding obligation, the
Optionee will reimburse the Company on demand, in cash, for the amount
underwithheld.

         11.      PURCHASE FOR INVESTMENT.

                  Unless the offering and sale of the Shares to be issued
upon the particular exercise of the Option shall have been effectively
registered under the Securities Act of 1933, as now in force or hereafter
amended (the "1933 Act"), the Company shall be under no obligation to issue
the Shares covered by such exercise unless and until the following conditions
have been fulfilled:

                  (a)      The person(s) who exercise the Option shall warrant
                           to the Company, at the time of such exercise, that
                           such person(s) are acquiring such Shares for their
                           own respective accounts, for investment, and not with
                           a view to, or for sale in connection with, the
                           distribution of any such Shares, in which event the
                           person(s) acquiring such Shares shall be bound by the
                           provisions of the following legend which shall be
                           endorsed upon the certificate(s) evidencing their
                           Option Shares issued pursuant to such exercise:

                           "The shares represented by this certificate have been
                           taken for investment and they may not be sold or
                           otherwise transferred by any person, including a
                           pledgee, unless (1) either (a) a Registration
                           Statement with respect to such shares shall be
                           effective under the Securities Act of 1933, as
                           amended, or (b) the Company shall have received an
                           opinion of counsel satisfactory to it that an
                           exemption from registration under such Act is then
                           available, and (2) there shall have been compliance
                           with all applicable state securities laws"; and

                  (b)      If the Company so requires, the Company shall have
                           received an opinion of its counsel that the Shares
                           may be issued upon such particular exercise in
                           compliance with the Act without registration
                           thereunder. Without limiting the generality of the
                           foregoing, the Company may delay issuance of the
                           Shares until completion of any action or obtaining of
                           any consent, which the Company deems necessary under
                           any applicable law (including without limitation
                           state securities or "blue sky" laws).

         12.      NO OBLIGATION TO MAINTAIN RELATIONSHIP.

         The Company is not by the Plan or this Option obligated to continue the
Optionee as an employee, consultant or director of the Company.


                                      -5-
<PAGE>

         13.      NOTICES.

                  Any notices required or permitted by the terms of this
Agreement or the Plan shall be given by recognized courier service, facsimile,
registered or certified mail, return receipt requested, addressed as follows:

       To the Company:          Variagenics, Inc.
                                60 Hampshire St.
                                Cambridge, MA 02139
                                ATTN:  Richard P. Shea, Chief Financial Officer

       To the Optionee:         NAME & ADDRESS


or to such other address or addresses of which notice in the same manner has
previously been given. Any such notice shall be deemed to have been given upon
the earlier of receipt, one business day following delivery to a recognized
courier service or three business days following mailing by registered or
certified mail.

         14.      GOVERNING LAW.

                  This Agreement shall be construed and enforced in accordance
with the law of the State of Delaware, without giving effect to the conflict of
law principles thereof.

         15.      BENEFIT OF AGREEMENT.

                  Subject to the provisions of the Plan and the other provisions
hereof, this Agreement shall be for the benefit of and shall be binding upon the
heirs, executors, administrators, successors and assigns of the parties hereto.

         16.      ENTIRE AGREEMENT.

         This Agreement, together with the Plan, embodies the entire agreement
and understanding between the parties hereto with respect to the subject matter
hereof and supersedes all prior oral or written agreements and understandings
relating to the subject matter hereof. No statement, representation, warranty,
covenant or agreement not expressly set forth in this Agreement shall affect or
be used to interpret, change or restrict, the express terms and provisions of
this Agreement, provided, however, in any event, this Agreement shall be subject
to and governed by the Plan.


                                      -6-
<PAGE>

         17.      MODIFICATIONS AND AMENDMENTS.

         The terms and provisions of this Agreement may be modified or amended
as provided in the Plan.

         18.      WAIVERS AND CONSENTS.

         Except as provided in the Plan, the terms and provisions of this
Agreement may be waived, or consent for the departure therefrom granted, only by
written document executed by the party entitled to the benefits of such terms or
provisions. No such waiver or consent shall be deemed to be or shall constitute
a waiver or consent with respect to any other terms or provisions of this
Agreement, whether or not similar. Each such waiver or consent shall be
effective only in the specific instance and for the purpose for which it was
given, and shall not constitute a continuing waiver or consent.

         IN WITNESS WHEREOF, the Company has caused this Agreement to be
executed by its duly authorized officer, and the Optionee has hereunto set his
or her hand, all as of the day and year first above written.

                                            VARIAGENICS, INC.


                                            By:
                                               --------------------------------
                                                    Richard P. Shea
                                                    Chief Financial Officer




                                               --------------------------------
                                                           Optionee


                                      -7-
<PAGE>

                                                                       EXHIBIT A

NOTICE OF EXERCISE OF NON-QUALIFIED STOCK OPTION

To:  Variagenics, Inc.

Ladies and Gentlemen:

         I hereby exercise my Non-Qualified Stock Option to purchase _____
shares (the "Securities") of the common stock, $.01 par value, of
Variagenics, Inc. (the "Company"), at the exercise price of PRICE per share,
pursuant to and subject to the terms of that certain Non-Qualified Stock
Option Agreement between the undersigned and the Company dated GRANT DATE.

         I understand the nature of the investment I am making and the financial
risks thereof. I am aware that it is my responsibility to have consulted with
competent tax and legal advisors about the relevant national, state and local
income tax and securities laws affecting the exercise of the Option and the
purchase and subsequent sale of the Shares.

         I am paying the option exercise price for the Shares as follows:



                ------------------------------------------------

         Please issue the stock certificate for the Shares (check one):

         / / to me; or

         / / to me and ____________________________, as joint tenants with
         right of survivorship,

         and mail the certificate to me at the following address:



         ----------------------------------------------------------------

         ----------------------------------------------------------------

         ----------------------------------------------------------------

         My mailing address for shareholder communications, if different from
the address listed above, is:



         ----------------------------------------------------------------

         ----------------------------------------------------------------

         ----------------------------------------------------------------


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<PAGE>

                              Very truly yours,


                              -------------------------------------------------
                              Optionee (signature)


                              -------------------------------------------------
                              Print Name


                              -------------------------------------------------
                              Date


                              -------------------------------------------------
                              Social Security Number


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