VARIAGENICS INC
S-1/A, EX-3.4, 2000-07-14
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                                                                   Exhibit 3.4


                                VARIAGENICS, INC.

                           AMENDED AND RESTATED BYLAWS



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                                TABLE OF CONTENTS

<TABLE>
<S>                                                                                                              <C>
ARTICLE I -STOCKHOLDERS...........................................................................................1

   SECTION 1.  ANNUAL MEETING.....................................................................................1
   SECTION 2.  SPECIAL MEETINGS...................................................................................1
   SECTION 3.  NOTICE OF MEETINGS.................................................................................1
   SECTION 4.  QUORUM.............................................................................................2
   SECTION 5.  ORGANIZATION AND CONDUCT OF BUSINESS...............................................................2
   SECTION 6.  NOTICE OF STOCKHOLDER BUSINESS AND NOMINATIONS.....................................................2
   SECTION 7.  PROXIES AND VOTING.................................................................................4
   SECTION 8.  ACTION WITHOUT MEETING.............................................................................5
   SECTION 9.  STOCK LIST.........................................................................................5

ARTICLE II -BOARD OF DIRECTORS....................................................................................6

   SECTION 1.  GENERAL POWERS, NUMBER, ELECTION, TENURE AND QUALIFICATION.........................................6
   SECTION 2.  VACANCIES AND NEWLY CREATED DIRECTORSHIPS..........................................................6
   SECTION 3.  RESIGNATION AND REMOVAL............................................................................7
   SECTION 4.  REGULAR MEETINGS...................................................................................7
   SECTION 5.  SPECIAL MEETINGS...................................................................................7
   SECTION 6.  QUORUM.............................................................................................7
   SECTION 7.  ACTION BY CONSENT..................................................................................8
   SECTION 8.  PARTICIPATION IN MEETINGS BY CONFERENCE TELEPHONE..................................................8
   SECTION 9.  CONDUCT OF BUSINESS................................................................................8
   SECTION 10. POWERS.............................................................................................8
   SECTION 11. COMPENSATION OF DIRECTORS..........................................................................9

ARTICLE III -COMMITTEES...........................................................................................9

   SECTION 1.  COMMITTEES OF THE BOARD OF DIRECTORS...............................................................9
   SECTION 2.  CONDUCT OF BUSINESS................................................................................9

ARTICLE IV -OFFICERS.............................................................................................10

   SECTION 1.  ENUMERATION.......................................................................................10
   SECTION 2.  ELECTION..........................................................................................10
   SECTION 3.  QUALIFICATION.....................................................................................10
   SECTION 4.  TENURE AND REMOVAL................................................................................10
   SECTION 5.  CHAIRMAN OF THE BOARD.............................................................................11
   SECTION 6.  CHIEF EXECUTIVE OFFICER...........................................................................11
   SECTION 7.  PRESIDENT.........................................................................................11
   SECTION 8.  VICE PRESIDENTS...................................................................................11
   SECTION 9.  CHIEF FINANCIAL OFFICER,TREASURER AND ASSISTANT TREASURERS........................................12
   SECTION 10. SECRETARY AND ASSISTANT SECRETARIES...............................................................12
   SECTION 11. BOND..............................................................................................12
   SECTION 12. ACTION WITH RESPECT TO SECURITIES OF OTHER CORPORATIONS...........................................13

ARTICLE V -STOCK.................................................................................................13

   SECTION 1.  CERTIFICATES OF STOCK.............................................................................13
   SECTION 2.  TRANSFERS OF STOCK................................................................................13
   SECTION 3.  RECORD DATE.......................................................................................13
   SECTION 4.  LOST, STOLEN OR DESTROYED CERTIFICATES............................................................14
   SECTION 5.  REGULATIONS.......................................................................................14
   SECTION 6.  INTERPRETATION....................................................................................14

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<S>                                                                                                              <C>
ARTICLE VI -NOTICES..............................................................................................14

   SECTION 1.  NOTICES...........................................................................................14
   SECTION 2.  WAIVER OF NOTICE..................................................................................15

ARTICLE VII -INDEMNIFICATION OF DIRECTORS AND OFFICERS...........................................................15

   SECTION 1.  RIGHT TO INDEMNIFICATION..........................................................................15
   SECTION 2.  RIGHT TO ADVANCEMENT OF EXPENSES..................................................................15
   SECTION 3.  RIGHT OF INDEMNITEES TO BRING SUIT................................................................16
   SECTION 4.  NON-EXCLUSIVITY OF RIGHTS.........................................................................16
   SECTION 5.  INSURANCE.........................................................................................17
   SECTION 6.  INDEMNIFICATION OF EMPLOYEES AND AGENTS OF THE CORPORATION........................................17

ARTICLE VIII -CERTAIN TRANSACTIONS...............................................................................17

   SECTION 1.  TRANSACTIONS WITH INTERESTED PARTIES..............................................................17
   SECTION 2.  QUORUM............................................................................................18

ARTICLE IX -MISCELLANEOUS........................................................................................18

   SECTION 1.  FACSIMILE SIGNATURES..............................................................................18
   SECTION 2.  CORPORATE SEAL....................................................................................18
   SECTION 3.  RELIANCE UPON BOOKS, REPORTS AND RECORDS..........................................................18
   SECTION 4.  FISCAL YEAR.......................................................................................18
   SECTION 5.  TIME PERIODS......................................................................................19
   SECTION 6.  PRONOUNS..........................................................................................19

ARTICLE X -AMENDMENTS............................................................................................19
</TABLE>

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                                VARIAGENICS, INC.

                           AMENDED AND RESTATED BYLAWS

                            ARTICLE I - STOCKHOLDERS

        SECTION 1.  ANNUAL MEETING.

        An annual meeting of the stockholders, for the election of directors to
succeed those whose terms expire and for the transaction of such other business
as may properly come before the meeting, shall be held at such place, on such
date, and at such time as the Board of Directors shall fix each year.

        SECTION 2.  SPECIAL MEETINGS.

        Subject to the rights of the holders of any class or series of preferred
stock of the Corporation, special meetings of stockholders of the Corporation
may be called only by the Board of Directors pursuant to a resolution adopted by
a majority of the total number of directors authorized. Special meetings of the
stockholders may be held at such place within or without the State of Delaware
as may be stated in such resolution.

        SECTION 3.  NOTICE OF MEETINGS.

        Written notice of the place, date, and time of all meetings of the
stockholders shall be given, not less than ten (10) nor more than sixty (60)
days before the date on which the meeting is to be held, to each stockholder
entitled to vote at such meeting, except as otherwise provided herein or
required by law (meaning, here and hereinafter, as required from time to time by
the Delaware General Corporation Law or the Certificate of Incorporation of the
Corporation, as amended and restated from time to time).

        When a meeting is adjourned to another place, date or time, written
notice need not be given of the adjourned meeting if the place, date and time
thereof are announced at the meeting at which the adjournment is taken;
provided, however, that if the date of any adjourned meeting is more than thirty
(30) days after the date for which the meeting was originally noticed, or if a
new record date is fixed for the adjourned meeting, written notice of the place,
date, and time of the adjourned meeting shall be given in conformity herewith.
At any adjourned meeting, any business may be transacted which might have been
transacted at the original meeting.

        SECTION 4.  QUORUM.

        At any meeting of the stockholders, the holders of a majority of all of
the shares of the stock entitled to vote at the meeting, present in person or by
proxy, shall constitute a quorum for all purposes, unless or except to the
extent that the presence of a larger number may be required by law. Where a
separate vote by a class or classes is required, a majority of the shares of
such class or

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classes present in person or represented by proxy shall constitute a quorum
entitled to take action with respect to that vote on that matter.

        If a quorum shall fail to attend any meeting, the chairman of the
meeting or the holders of a majority of the shares of stock entitled to vote who
are present, in person or by proxy, may adjourn the meeting to another place,
date, or time.

        SECTION 5.  ORGANIZATION AND CONDUCT OF BUSINESS.

        The Chairman of the Board of Directors or, in his or her absence, the
Chief Executive Officer of the Corporation or, in his or her absence, the
President or, in his or her absence, such person as the Board of Directors may
have designated, shall call to order any meeting of the stockholders and shall
preside at and act as chairman of the meeting. In the absence of the Secretary
of the Corporation, the secretary of the meeting shall be such person as the
chairman of the meeting appoints. The chairman of any meeting of stockholders
shall determine the order of business and the procedures at the meeting,
including such regulation of the manner of voting and the conduct of discussion
as he or she deems to be appropriate. The chairman of any meeting of
stockholders shall have the power to adjourn the meeting to another place and
time

       SECTION 6.   NOTICE OF STOCKHOLDER BUSINESS AND NOMINATIONS.

         A.  ANNUAL MEETINGS OF STOCKHOLDERS.

             Nominations of persons for election to the Board of Directors
and the proposal of business to be considered by the stockholders may be made at
an annual meeting of stockholders (a) pursuant to the Corporation's notice of
meeting, (b) by or at the direction of the Board of Directors or (c) by any
stockholder of the Corporation who was a stockholder of record at the time of
giving of notice provided for in this Section, who is entitled to vote at the
meeting and who complies with the notice procedures set forth in this Section.

         B.  SPECIAL MEETINGS OF STOCKHOLDERS.

         Only such business shall be conducted at a special meeting of
stockholders as shall have been brought before the meeting pursuant to the
notice of meeting given pursuant to Section 2 above. Nominations of persons for
election to the Board of Directors may be made at a special meeting of
stockholders at which directors are to be elected (a) by or at the direction of
the Board of Directors or (b) provided that the Board of Directors has
determined that directors shall be elected at such meeting, by any stockholder
of the Corporation who is a stockholder of record at the time of giving of
notice of the special meeting, who shall be entitled to vote at the meeting and
who complies with the notice procedures set forth in this Section.

         C.  CERTAIN MATTERS PERTAINING TO STOCKHOLDER BUSINESS AND NOMINATIONS.

                  (1) For nominations or other business to be properly brought
before an annual meeting by a stockholder pursuant to clause (c) of paragraph A
of this Section or a special meeting pursuant to paragraph B of this Section,
the stockholder must have given timely notice thereof in writing to the
Secretary of the Corporation and such other business must otherwise be a proper

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matter for stockholder action. To be timely, a stockholder's notice pertaining
to an annual meeting shall be delivered to the Secretary at the principal
executive offices of the Corporation not later than the close of business on the
sixtieth (60th) day nor earlier than the close of business on the ninetieth
(90th) day prior to the first anniversary of the preceding year's annual
meeting; PROVIDED, HOWEVER, that in the event that the date of the annual
meeting is more than thirty (30) days before or more than sixty (60) days after
such an anniversary date, notice by the stockholder to be timely must be so
delivered not earlier than the close of business on the ninetieth (90th) day
prior to such annual meeting and not later than the close of business on the
later of the sixtieth (60th) day prior to such annual meeting or the close of
business on the tenth (10th) day following the day on which public announcement
of the date of such meeting is first made by the Corporation. Such stockholder's
notice for an annual meeting or a special meeting shall set forth: (a) as to
each person whom the stockholder proposes to nominate for election or reelection
as a director, all information relating to such person that is required to be
disclosed in solicitations of proxies for election of directors, or is otherwise
required, in each case, pursuant to Regulation 14A under the Securities Exchange
Act of 1934, as amended (the "Exchange Act") (including such person's written
consent to being named in the proxy statement as a nominee and to serving as a
director if elected); (b) as to any other business that the stockholder proposes
to bring before the meeting, a brief description of the business desired to be
brought before the meeting, the reasons for conducting such business at the
meeting and any material interest in such business of such stockholder and the
beneficial owner, if any, on whose behalf the proposal is made; and (c) as to
the stockholder giving the notice and the beneficial owner, if any, on whose
behalf the nomination or proposal is made (i) the name and address of such
stockholder, as they appear on the Corporation's books, and of such beneficial
owner, (ii) the class and number of shares of the Corporation that are owned
beneficially and held of record by such stockholder and such beneficial owner,
and (iii) whether either such stockholder or beneficial owner intends to deliver
a proxy statement and form of proxy to holders of, in the case of a proposal, at
least the percentage of the Corporation's voting shares required under
applicable law to carry the proposal or, in the case of a nomination or
nominations, a sufficient number of holders of the Corporation's voting shares
to elect such nominee or nominees. A stockholder shall also comply with all
applicable requirements of the Exchange Act (or any successor provision), and
the rules and regulations thereunder with respect to the matters set forth in
these Bylaws.

                  (2) Notwithstanding anything in the second sentence of
paragraph C (1) of this Section to the contrary, in the event that the number of
directors to be elected to the Board of Directors of the Corporation is
increased and there is no public announcement by the Corporation naming all of
the nominees for director or specifying the size of the increased Board of
Directors at least seventy (70) days prior to the first anniversary of the
preceding year's annual meeting (or, if the annual meeting is held more than
thirty (30) days before or sixty (60) days after such anniversary date, at least
seventy (70) days prior to such annual meeting), a stockholder's notice required
by this Section shall also be considered timely, but only with respect to
nominees for any new positions created by such increase, if it shall be
delivered to the Secretary at the principal executive office of the Corporation
not later than the close of business on the tenth (10th) day following the day
on which such public announcement is first made by the Corporation.

                  (3) In the event the Corporation calls a special meeting of
stockholders for the purpose of electing one or more directors to the Board of
Directors, any such stockholder may nominate a person or persons (as the case
may be), for election to such position(s) as specified in

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the Corporation's notice of meeting, if the stockholder's notice required by
paragraph C(1) of this Section shall be delivered to the Secretary at the
principal executive offices of the Corporation not earlier than the ninetieth
(90th) day prior to such special meeting nor later than the close of business on
the later of the sixtieth (60th) day prior to such special meeting, or the tenth
(10th) day following the day on which public announcement is first made of the
date of the special meeting and of the nominees proposed by the Board of
Directors to be elected at such meeting.

         D.  GENERAL.

             (1) Only such persons who are nominated in accordance with the
procedures set forth in this Section shall be eligible to serve as directors and
only such business shall be conducted at a meeting of stockholders as shall have
been brought before the meeting in accordance with the procedures set forth in
this Section. Except as otherwise provided by law or these Bylaws, the chairman
of the meeting shall have the power and duty to determine whether a nomination
or any business proposed to be brought before the meeting was made or proposed,
as the case may be, in accordance with the procedures set forth in this Section
and, if any proposed nomination or business is not in compliance herewith, to
declare that such defective proposal or nomination shall be disregarded.

             (2) For purposes of this Section, "public announcement" shall
mean disclosure in a press release reported by the Dow Jones News Service,
Associated Press or comparable national news service or in a document publicly
filed by the Corporation with the Securities and Exchange Commission pursuant to
Section 13, 14 or 15(d) of the Exchange Act.

             (3) Notwithstanding the foregoing provisions of this Section,
a stockholder shall also comply with all applicable requirements of the Exchange
Act and the rules and regulations thereunder with respect to the matters set
forth herein. Nothing in this Section shall be deemed to affect any rights (i)
of stockholders to request inclusion of proposals in the Corporation's proxy
statement pursuant to Rule 14a-8 under the Exchange Act or (ii) of the holders
of any series of Preferred Stock to elect directors under specified
circumstances.


        SECTION 7.  PROXIES AND VOTING.

             At any meeting of the stockholders, every stockholder entitled to
vote may vote in person or by proxy authorized by an instrument in writing or by
a transmission permitted by law filed in accordance with the procedure
established for the meeting. Any copy, facsimile telecommunication or other
reliable reproduction of the writing or transmission created pursuant to this
Section may be substituted or used in lieu of the original writing or
transmission for any and all purposes for which the original writing or
transmission could be used, provided that such copy, facsimile telecommunication
or other reproduction shall be a complete reproduction of the entire original
writing or transmission.

         All voting, including on the election of directors but excepting where
otherwise required by law, may be by voice vote. Any vote not taken by voice
shall be taken by ballots, each of which shall state the name of the stockholder
or proxy voting and such other information as may

                                       4
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be required under the procedure established for the meeting. The Corporation
may, and to the extent required by law, shall, in advance of any meeting of
stockholders, appoint one or more inspectors to act at the meeting and make a
written report thereof. The Corporation may designate one or more persons as
alternate inspectors to replace any inspector who fails to act. If no inspector
or alternate is able to act at a meeting of stockholders, the person presiding
at the meeting may, and to the extent required by law, shall, appoint one or
more inspectors to act at the meeting. Each inspector, before entering upon the
discharge of his duties, shall take and sign an oath faithfully to execute the
duties of inspector with strict impartiality and according to the best of his
ability.

         Except as otherwise provided in the terms of any class or series of
Preferred Stock of the Corporation, all elections at any meeting of stockholders
shall be determined by a plurality of the votes cast, and except as otherwise
required by law, all other matters determined by stockholders at a meeting shall
be determined by a majority of the votes cast affirmatively or negatively.

        SECTION 8.  ACTION WITHOUT MEETING.

        Any action required or permitted to be taken by the stockholders of the
Corporation may be effected only at a duly called annual or special meeting of
stockholders of the Corporation and may not be effected by written consent.

        SECTION 9.  STOCK LIST.

        A complete list of stockholders entitled to vote at any meeting of
stockholders, arranged in alphabetical order for each class of stock and showing
the address of each such stockholder and the number of shares registered in his
or her name, shall be open to the examination of any such stockholder, for any
purpose germane to the meeting, during ordinary business hours for a period of
at least ten (10) days prior to the meeting, either at a place within the city
where the meeting is to be held, which place shall be specified in the notice of
the meeting, or if not so specified, at the place where the meeting is to be
held.

        The stock list shall also be kept at the place of the meeting during the
whole time thereof and shall be open to the examination of any such stockholder
who is present. Such list shall presumptively determine the identity of the
stockholders entitled to vote at the meeting and the number of shares held by
each of them.


                         ARTICLE II - BOARD OF DIRECTORS

        SECTION 1.  GENERAL POWERS, NUMBER, ELECTION, TENURE AND QUALIFICATION.

         A. The business and affairs of the Corporation shall be managed by or
under the direction of its Board of Directors.

         B. Subject to the rights of the holders of any series of Preferred
Stock then outstanding to elect additional directors under specified
circumstances, the number of directors shall be fixed

                                       5
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from time to time exclusively by the Board of Directors pursuant to a resolution
adopted by a majority of the Board.

         C. On or prior to the Effective Time, as defined in Article FOURTH of
the Corporation's Restated Certificate of Incorporation, the Board of Directors
of the Corporation shall divide the directors into three classes, as nearly
equal in number as reasonably possible, with the term of office of the first
class to expire at the annual meeting of stockholders or any special meeting in
lieu thereof in 2001, the term of office of the second class to expire at the
annual meeting of stockholders or any special meeting in lieu thereof in 2002,
and the term of office of the third class to expire at the annual meeting of
stockholders or any special meeting in lieu thereof in 2003. At each annual
meeting of stockholders or special meeting in lieu thereof following such
initial classification, directors elected to succeed those directors whose terms
expire shall be elected for a term of office to expire at the third succeeding
annual meeting of stockholders or special meeting in lieu thereof after their
election and until their successors are duly elected and qualified.

        SECTION 2.  VACANCIES AND NEWLY CREATED DIRECTORSHIPS.

        Subject to the rights of the holders of any series of Preferred Stock
then outstanding, newly created directorships resulting from any increase in the
authorized number of directors or any vacancies in the Board of Directors
resulting from death, resignation, retirement, disqualification, removal from
office or other cause may be filled only by a majority vote of the directors
then in office even though less than a quorum, or by a sole remaining director.
In the event of any increase or decrease in the authorized number of directors,
(i) each director then serving as such shall nevertheless continue as a director
of the class of which he is a member until the expiration of his current term or
his prior death, retirement, removal or resignation and (ii) the newly created
or eliminated directorships resulting from such increase or decrease shall if
reasonably possible be apportioned by the Board of Directors among the three
classes of directors so as to ensure that no one class has more than one
director more than any other class. To the extent reasonably possible,
consistent with the foregoing rule, any newly created directorships shall be
added to those classes whose terms of office are to expire at the latest dates
following such allocation and newly eliminated directorships shall be subtracted
from those classes whose terms of office are to expire at the earliest dates
following such allocation, unless otherwise provided for from time to time by
resolution adopted by a majority of the directors then in office, although less
than a quorum. In the event of a vacancy in the Board of Directors, the
remaining directors, except as otherwise provided by law, may exercise the
powers of the full Board of Directors until the vacancy is filled.

        SECTION 3.  RESIGNATION AND REMOVAL.

        Any director may resign at any time upon written notice to the
Corporation at its principal place of business or to the Chairman of the Board,
Chief Executive Officer, President or Secretary. Such resignation shall be
effective upon receipt unless it is specified to be effective at some other time
or upon the happening of some other event. Subject to the rights of the holders
of any series of Preferred Stock then outstanding, any director, or the entire
Board of Directors, may be removed from office at any time only for cause. A
director may be removed for cause by the holders of a majority of the shares of
the Corporation then entitled to vote at an election of a director and only
after a reasonable notice and opportunity to be heard before the stockholders.

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        SECTION 4.  REGULAR MEETINGS.

        Regular meetings of the Board of Directors shall be held at such place
or places, on such date or dates, and at such time or times as shall have been
established by the Board of Directors and publicized among all directors. A
written notice of each regular meeting shall not be required.

        SECTION 5.  SPECIAL MEETINGS.

        Special meetings of the Board of Directors may be called by the Chairman
of the Board of Directors or the Chief Executive Officer, and shall be called by
the Secretary if requested by a majority of the Board of Directors, and shall be
held at such place, on such date, and at such time as he or she or they shall
fix. Notice of the place, date, and time of each such special meeting shall be
given to each director by whom it is not waived by mailing written notice not
less than three (3) days before the meeting or orally, by telegraph, telex,
cable or telecopy given not less than twenty-four (24) hours before the meeting.
Unless otherwise indicated in the notice thereof, any and all business may be
transacted at a special meeting.

        SECTION 6.  QUORUM.

        At any meeting of the Board of Directors, a majority of the total number
of members of the Board of Directors shall constitute a quorum for all purposes.
If a quorum shall fail to attend any meeting, a majority of those present may
adjourn the meeting to another place, date, or time, without further notice or
waiver thereof.

        SECTION 7.  ACTION BY CONSENT.

        Unless otherwise restricted by the Certificate of Incorporation or these
Bylaws, any action required or permitted to be taken at any meeting of the Board
of Directors or of any committee thereof may be taken without a meeting, if all
members of the Board or committee, as the case may be, consent thereto in
writing, and the writing or writings are filed with the minutes of proceedings
of the Board or committee.

        SECTION 8.  PARTICIPATION IN MEETINGS BY CONFERENCE TELEPHONE.

        Members of the Board of Directors, or of any committee thereof, may
participate in a meeting of such Board or committee by means of conference
telephone or similar communications equipment by means of which all persons
participating in the meeting can hear each other and such participation shall
constitute presence in person at such meeting.

        SECTION 9.  CONDUCT OF BUSINESS.

        At any meeting of the Board of Directors, business shall be transacted
in such order and manner as the Board may from time to time determine, and all
matters shall be determined by the vote of a majority of the directors present,
except as otherwise provided herein or required by law.

                                       7
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        SECTION 10. POWERS.

        The Board of Directors may, except as otherwise required by law,
exercise all such powers and do all such acts and things as may be exercised or
done by the Corporation, including, without limiting the generality of the
foregoing, the unqualified power:

                (1)  To declare dividends from time to time in accordance with
                     law;

                (2)  To purchase or otherwise acquire any property, rights or
                     privileges on such terms as it shall determine;

                (3)  To authorize the creation, making and issuance, in such
                     form as it may determine, of written obligations of every
                     kind, negotiable or non-negotiable, secured or unsecured,
                     to borrow funds and guarantee obligations, and to do all
                     things necessary in connection therewith;

                (4)  To remove any officer of the Corporation with or without
                     cause, and from time to time to devolve the powers and
                     duties of any officer upon any other person for the time
                     being;

                (5)  To confer upon any officer of the Corporation the power to
                     appoint, remove and suspend subordinate officers, employees
                     and agents;

                (6)  To adopt from time to time such stock, option, stock
                     purchase, bonus or other compensation plans for directors,
                     officers, employees and agents of the Corporation and its
                     subsidiaries as it may determine;

                (7)  To adopt from time to time such insurance, retirement, and
                     other benefit plans for directors, officers, employees and
                     agents of the Corporation and its subsidiaries as it may
                     determine; and,

                (8)  To adopt from time to time regulations, not inconsistent
                     with these Bylaws, for the management of the Corporation's
                     business and affairs.

        SECTION 11.  COMPENSATION OF DIRECTORS.

        Directors, as such, may receive, pursuant to a resolution of the Board
of Directors, fixed fees and other compensation for their services as directors,
including, without limitation, their services as members of committees of the
Board of Directors.


                            ARTICLE III - COMMITTEES

        SECTION 1.   COMMITTEES OF THE BOARD OF DIRECTORS.

        The Board of Directors, by a vote of a majority of the Board of
Directors, may from time to time designate committees of the Board, with such
lawfully delegable powers and duties as it

                                       8
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thereby confers, to serve at the pleasure of the Board and shall, for those
committees and any others provided for herein, elect a director or directors to
serve as the member or members, designating, if it desires, other directors as
alternate members who may replace any absent or disqualified member at any
meeting of the committee. Any such committee, to the extent provided in the
resolution of the Board of Directors, shall have and may exercise all the powers
and authority of the Board of Directors in the management of the business and
affairs of the Corporation to the fullest extent authorized by law. In the
absence or disqualification of any member of any committee and any alternate
member in his or her place, the member or members of the committee present at
the meeting and not disqualified from voting, whether or not he or she or they
constitute a quorum, may by unanimous vote appoint another member of the Board
of Directors to act at the meeting in the place of the absent or disqualified
member.

        SECTION 2.  CONDUCT OF BUSINESS.

        Each committee may determine the procedural rules for meeting and
conducting its business and shall act in accordance therewith, except as
otherwise provided herein or required by law. Adequate provision shall be made
for notice to members of all meetings; one-third (1/3) of the members of any
committee shall constitute a quorum unless the committee shall consist of one
(1) or two (2) members, in which event one (1) member shall constitute a quorum;
and all matters shall be determined by a majority vote of the members present.
Action may be taken by any committee without a meeting if all members thereof
consent thereto in writing, and the writing or writings are filed with the
minutes of the proceedings of such committee.


                              ARTICLE IV - OFFICERS

        SECTION 1.  ENUMERATION.

        The officers of the Corporation shall consist of a Chairman of the
Board, Chief Executive Officer, President, Chief Financial Officer, Treasurer,
Secretary and such other officers as the Board of Directors or the Chief
Executive Officer may determine, including, but not limited to, a Chief
Technology Officer, Chief Medical Officer, and one or more Executive Vice
Presidents, Vice Presidents, Assistant Treasurers and Assistant Secretaries.

        SECTION 2.  ELECTION.

        The Chairman of the Board, Chief Executive Officer, President, Chief
Financial Officer, Treasurer and the Secretary shall be elected annually by the
Board of Directors at their first meeting following the annual meeting of the
stockholders. The Board of Directors or the Chief Executive Officer, may, from
time to time, elect or appoint such other officers as it or he or she may
determine, including, but not limited to, a Chief Technology Officer, and one or
more Vice Presidents, Assistant Treasurers and Assistant Secretaries.

        SECTION 3.  QUALIFICATION.

        The Chairman of the Board, if any, and any Vice Chairman appointed to
act in the absence of the Chairman, if any, shall be elected by and from the
Board of Directors, but no other officer need

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be a director. Two or more offices may be held by any one person. If required by
vote of the Board of Directors, an officer shall give bond to the Corporation
for the faithful performance of his or her duties, in such form and amount and
with such sureties as the Board of Directors may determine. The premiums for
such bonds shall be paid by the Corporation.

        SECTION 4.  TENURE AND REMOVAL.

        Each officer elected or appointed by the Board of Directors shall hold
office until the first meeting of the Board of Directors following the next
annual meeting of the stockholders and until his or her successor is elected or
appointed and qualified, or until he or she dies, resigns, is removed or becomes
disqualified, unless a shorter term is specified in the vote electing or
appointing said officer. Each officer appointed by the Chief Executive Officer,
shall hold office until his or her successor is elected or appointed and
qualified, or until he or she dies, resigns, is removed or becomes disqualified,
unless a shorter term is specified by any agreement or other instrument
appointing such officer. Any officer may resign by giving written notice of his
or her resignation to the Chief Executive Officer, the President, or the
Secretary, or to the Board of Directors at a meeting of the Board, and such
resignation shall become effective at the time specified therein. Any officer
elected or appointed by the Board of Directors may be removed from office with
or without cause only by vote of a majority of the directors. Any officer
appointed by the Chief Executive Officer may be removed with or without cause by
the Chief Executive Officer or by vote of a majority of the directors.

        SECTION 5.  CHAIRMAN OF THE BOARD.

        The Chairman of the Board, if any, shall preside at all meetings of the
Board of Directors and stockholders at which he or she is present and shall have
such authority and perform such duties as may be prescribed by these Bylaws or
from time to time be determined by the Board of Directors.

        SECTION 6.  CHIEF EXECUTIVE OFFICER.

        The Chief Executive Officer shall be the chief executive officer of the
Corporation and shall, subject to the direction of the Board of Directors, have
general supervision and control of its business. Unless otherwise provided by
resolution of the Board of Directors, in the absence of the Chairman of the
Board, the Chief Executive Officer shall preside at all meetings of the
stockholders and, if a director, meetings of the Board of Directors. The Chief
Executive Officer shall have general supervision and direction of all of the
officers, employees and agents of the Corporation. The Chief Executive Officer
shall also have the power and authority to determine the duties of all officers,
employees and agents of the Corporation, shall determine the compensation of any
officers whose compensation is not established by the Board of Directors and
shall have the power and authority to sign all stock certificates, contracts and
other instruments of the Corporation which are authorized.

        SECTION 7.  PRESIDENT.

        Except for meetings at which the Chief Executive Officer or the Chairman
of the Board, if any, presides, the President shall, if present, preside at all
meetings of stockholders, and if a director, at all meetings of the Board of
Directors. The President shall, subject to the control and

                                       10
<PAGE>

direction of the Chief Executive Officer and the Board of Directors, have and
perform such powers and duties as may be prescribed by these Bylaws or from time
to time be determined by the Chief Executive Officer or the Board of Directors.
The President shall have power to sign all stock certificates, contracts and
other instruments of the Corporation which are authorized. In the absence of a
Chief Executive Officer, the President shall be the chief executive officer of
the Corporation and shall, subject to the direction of the Board of Directors,
have general supervision and control of its business and shall have general
supervision and direction of all of the officers, employees and agents of the
Corporation.

        SECTION 8.  VICE PRESIDENTS.

        The Vice Presidents, if any, in the order of their election, or in such
other order as the Board of Directors or the Chief Executive Officer may
determine, shall have and perform the powers and duties of the President (or
such of the powers and duties as the Board of Directors or the Chief Executive
Officer may determine) whenever the President is absent or unable to act. The
Vice Presidents, if any, shall also have such other powers and duties as may
from time to time be determined by the Board of Directors or the Chief Executive
Officer.

        SECTION 9.  CHIEF FINANCIAL OFFICER, TREASURER AND ASSISTANT TREASURERS.

        The Chief Financial Officer shall also be the Treasurer. The Chief
Financial Officer and/or Treasurer shall, subject to the control and direction
of the Board of Directors and the Chief Executive Officer, have and perform such
powers and duties as may be prescribed in these Bylaws or be determined from
time to time by the Board of Directors and the Chief Executive Officer. All
property of the Corporation in the custody of the Chief Financial Officer and/or
Treasurer shall be subject at all times to the inspection and control of the
Board of Directors and the Chief Executive Officer. The Chief Financial Officer
and/or Treasurer shall have the responsibility for maintaining the financial
records of the Corporation. The Chief Financial Officer and/or Treasurer shall
make such disbursements of the funds of the Corporation as are authorized and
shall render from time to time an account of all such transactions and of the
financial condition of the Corporation. Unless otherwise voted by the Board of
Directors or by the Chief Executive Officer, each Assistant Treasurer, if any,
shall have and perform the powers and duties of the Chief Financial Officer
and/or Treasurer whenever the Chief Financial Officer and/or Treasurer is absent
or unable to act, and may at any time exercise such of the powers of the Chief
Financial Officer and/or Treasurer, and such other powers and duties, as may
from time to time be determined by the Board of Directors or the Chief Executive
Officer.

        SECTION 10. SECRETARY AND ASSISTANT SECRETARIES.

        The Board of Directors or the Chief Executive Officer shall appoint a
Secretary and, in his or her absence, an Assistant Secretary. Unless otherwise
directed by the Board of Directors, the Secretary or, in his or her absence, any
Assistant Secretary, shall attend all meetings of the directors and stockholders
and shall record all votes of the Board of Directors and stockholders and
minutes of the proceedings at such meetings. The Secretary or, in his or her
absence, any Assistant Secretary, shall notify the directors of their meetings,
and shall have and perform such other powers and duties as may from time to time
be determined by the Board of Directors. If the Secretary or an

                                       11
<PAGE>

Assistant Secretary is elected but is not present at any meeting of directors or
stockholders, a temporary Secretary may be appointed by the directors or the
Chief Executive Officer at the meeting

        SECTION 11.  BOND.

        If required by the Board of Directors, any officer shall give the
Corporation a bond in such sum and with such surety or sureties and upon such
terms and conditions as shall be satisfactory to the Board of Directors,
including without limitation a bond for the faithful performance of the duties
of his office and for the restoration to the Corporation of all books, papers,
vouchers, money and other property of whatever kind in his or her possession or
under his control and belonging to the Corporation.

        SECTION 12.  ACTION WITH RESPECT TO SECURITIES OF OTHER CORPORATIONS.

        Unless otherwise directed by the Board of Directors or the Chief
Executive Officer, the Chief Financial Officer and/or Treasurer shall have power
to vote and otherwise act on behalf of the Corporation, in person or by proxy,
at any meeting of stockholders of or with respect to any action of stockholders
of any other corporation in which this Corporation may hold securities and
otherwise to exercise any and all rights and powers which this Corporation may
possess by reason of its ownership of securities in such other corporation.


                                ARTICLE V - STOCK

        SECTION 1.   CERTIFICATES OF STOCK.

        Each stockholder shall be entitled to a certificate signed by, or in the
name of the Corporation by the Chairman of the Board of Directors, Chief
Executive Officer, or the President or a Vice President, and by the Treasurer or
an Assistant Treasurer, or the Secretary or an Assistant Secretary, certifying
the number of shares owned by him or her. Any or all of the signatures on the
certificate may be by facsimile.

        SECTION 2.   TRANSFERS OF STOCK.

        Transfers of stock shall be made only upon the transfer books of the
Corporation kept at an office of the Corporation or by transfer agents
designated to transfer shares of the stock of the Corporation. Except where a
certificate is issued in accordance with Section 4 of this Article of these
Bylaws, an outstanding certificate for the number of shares involved shall be
surrendered for cancellation before a new certificate is issued therefor.

        SECTION 3.   RECORD DATE.

        In order that the Corporation may determine the stockholders entitled to
notice of or to vote at any meeting of stockholders, or to receive payment of
any dividend or other distribution or allotment of any rights or to exercise any
rights in respect of any change, conversion or exchange of stock or for the
purpose of any other lawful action, the Board of Directors may fix a record
date,

                                       12
<PAGE>

which record date shall not precede the date on which the resolution fixing the
record date is adopted and which record date shall not be more than sixty (60)
nor less than ten (10) days before the date of any meeting of stockholders, nor
more than sixty (60) days prior to the time for such other action as
hereinbefore described; provided, however, that if no record date is fixed by
the Board of Directors, the record date for determining stockholders entitled to
notice of or to vote at a meeting of stockholders shall be at the close of
business on the day next preceding the day on which notice is given or, if
notice is waived, at the close of business on the day next preceding the day on
which the meeting is held, and, for determining stockholders entitled to receive
payment of any dividend or other distribution or allotment of rights or to
exercise any rights of change, conversion or exchange of stock or for any other
purpose, the record date shall be at the close of business on the day on which
the Board of Directors adopts a resolution relating thereto.

        A determination of stockholders of record entitled to notice of or to
vote at a meeting of stockholders shall apply to any adjournment of the meeting;
provided, however, that the Board of Directors may fix a new record date for the
adjourned meeting.

        SECTION 4.  LOST, STOLEN OR DESTROYED CERTIFICATES.

        In the event of the loss, theft or destruction of any certificate of
stock, another may be issued in its place pursuant to such regulations as the
Board of Directors may establish concerning proof of such loss, theft or
destruction and concerning the giving of a satisfactory bond or bonds of
indemnity.

        SECTION 5.  REGULATIONS.

        The issue, transfer, conversion and registration of certificates of
stock shall be governed by such other regulations as the Board of Directors may
establish.

        SECTION 6.  INTERPRETATION.

        The Board of Directors shall have the power to interpret all of the
terms and provisions of these Bylaws, which interpretation shall be conclusive.


                              ARTICLE VI - NOTICES

        SECTION 1.  NOTICES.

        Except as otherwise specifically provided herein or required by law, all
notices required to be given to any stockholder, director, officer, employee or
agent shall be in writing and may in every instance be effectively given by hand
delivery to the recipient thereof, by depositing such notice in the mail,
postage paid, or by sending such notice by courier service, prepaid telegram or
mailgram, or telecopy, cable, or telex. Any such notice shall be addressed to
such stockholder, director, officer, employee or agent at his or her last known
address as the same appears on the books of the Corporation. The time when such
notice is received, if hand delivered, or dispatched, if delivered through the
mail or by courier, telegram, mailgram, telecopy, cable, or telex shall be the
time of the giving of the notice.

                                       13
<PAGE>

        SECTION 2.  WAIVER OF NOTICE.

        A written waiver of any notice, signed by a stockholder, director,
officer, employee or agent, whether before or after the time of the event for
which notice is to be given, shall be deemed equivalent to the notice required
to be given to such stockholder, director, officer, employee or agent. Neither
the business nor the purpose of any meeting need be specified in such a waiver.
Attendance of a director or stockholder at a meeting without protesting prior
thereto or at its commencement the lack of notice shall also constitute a waiver
of notice by such director or stockholder.


             ARTICLE VII -INDEMNIFICATION OF DIRECTORS AND OFFICERS

         SECTION 1.  RIGHT TO INDEMNIFICATION.

         Each person who was or is made a party or is threatened to be made a
party to or is otherwise involved (including, without limitation, as a witness)
in any action, suit or proceeding, whether civil, criminal, administrative or
investigative, by reason of the fact that he is or was a director or an officer
of the Corporation or is or was serving at the request of the Corporation as a
director, officer, employee or agent of another corporation, or of a
partnership, joint venture, trust or other enterprise, including service with
respect to an employee benefit plan (hereinafter an "Indemnitee"), whether the
basis of such proceeding is alleged action in an official capacity as a
director, officer, employee or agent or in any other capacity while serving as a
director, officer, employee or agent, shall be indemnified and held harmless by
the Corporation to the fullest extent authorized by the Delaware General
Corporation Law, as the same exists or may hereafter be amended (but, in the
case of any such amendment, only to the extent that such amendment permits the
Corporation to provide broader indemnification rights than such law permitted
the Corporation to provide prior to such amendment), against all expense,
liability and loss (including attorneys' fees, judgments, fines, ERISA excise
taxes or penalties and amounts paid in settlement) reasonably incurred or
suffered by such Indemnitee in connection therewith; provided, however, that,
except as provided in Section 3 of this Article with respect to proceedings to
enforce rights to indemnification or as otherwise required by law, the
Corporation shall not be required to indemnify or advance expenses to any such
Indemnitee in connection with a proceeding (or part thereof) initiated by such
Indemnitee unless such proceeding (or part thereof) was authorized by the Board
of Directors of the Corporation.

         SECTION 2. RIGHT TO ADVANCEMENT OF EXPENSES.

         The right to indemnification conferred in Section 1 of this Article
shall include the right to be paid by the Corporation the expenses (including
attorney's fees) incurred in defending any such proceeding in advance of its
final disposition; provided, however, that, if the Delaware General Corporation
Law requires, an advancement of expenses incurred by an Indemnitee in his
capacity as a director or officer (and not in any other capacity in which
service was or is rendered by such Indemnitee, including, without limitation,
service to an employee benefit plan) shall be made only upon delivery to the
Corporation of an undertaking, by or on behalf of such Indemnitee, to repay all
amounts so advanced if it shall ultimately be determined by final judicial
decision from which there

                                       14
<PAGE>

is no further right to appeal that such Indemnitee is not entitled to be
indemnified for such expenses under this Section 2 or otherwise. The rights to
indemnification and to the advancement of expenses conferred in Sections 1 and 2
of this Article shall be contract rights and such rights shall continue as to an
Indemnitee who has ceased to be a director, officer, employee or agent and shall
inure to the benefit of the Indemnitee's heirs, executors and administrators.
Any repeal or modification of any of the provisions of this Article shall not
adversely affect any right or protection of an Indemnitee existing at the time
of such repeal or modification.

         SECTION 3.  RIGHT OF INDEMNITEES TO BRING SUIT.

         If a claim under Section 1 or 2 of this Article is not paid in full by
the Corporation within sixty (60) days after a written claim has been received
by the Corporation, except in the case of a claim for an advancement of
expenses, in which case the applicable period shall be twenty (20) days, the
Indemnitee may at any time thereafter bring suit against the Corporation to
recover the unpaid amount of the claim. If successful in whole or in part in any
such suit, or in a suit brought by the Corporation to recover an advancement of
expenses pursuant to the terms of an undertaking, the Indemnitee shall also be
entitled to be paid the expenses of prosecuting or defending such suit. In (i)
any suit brought by the Indemnitee to enforce a right to indemnification
hereunder (but not in a suit brought by the Indemnitee to enforce a right to an
advancement of expenses) it shall be a defense that, and (ii) in any suit
brought by the Corporation to recover an advancement of expenses pursuant to the
terms of an undertaking, the Corporation shall be entitled to recover such
expenses upon a final adjudication that, the Indemnitee has not met any
applicable standard for indemnification set forth in the Delaware General
Corporation Law. Neither the failure of the Corporation (including its board of
directors, independent legal counsel, or its stockholders) to have made a
determination prior to the commencement of such suit that indemnification of the
Indemnitee is proper in the circumstances because the Indemnitee has met the
applicable standard of conduct set forth in the Delaware General Corporation
Law, nor an actual determination by the Corporation (including its board of
directors, independent legal counsel, or its stockholders) that the Indemnitee
has not met such applicable standard of conduct, shall create a presumption that
the Indemnitee has not met the applicable standard of conduct or, in the case of
such a suit brought by the Indemnitee, be a defense to such suit. In any suit
brought by the Indemnitee to enforce a right to indemnification or to an
advancement of expenses hereunder, or brought by the Corporation to recover an
advancement of expenses pursuant to the terms of an undertaking, the burden of
proving that the Indemnitee is not entitled to be indemnified, or to such
advancement of expenses, under this Article or otherwise shall be on the
Corporation.

         SECTION 4.  NON-EXCLUSIVITY OF RIGHTS.

         The rights to indemnification and to the advancement of expenses
conferred in this Article shall not be exclusive of any other right which any
person may have or hereafter acquire under any statute, the Corporation's
Certificate of Incorporation as amended from time to time, these Bylaws, any
agreement, any vote of stockholders or disinterested directors or otherwise.

                                       15
<PAGE>

         SECTION 5.  INSURANCE.

         The Corporation may maintain insurance, at its expense, to protect
itself and any director, officer, employee or agent of the Corporation or
another corporation, partnership, joint venture, trust or other enterprise
against any expense, liability or loss, whether or not the Corporation would
have the power to indemnify such person against such expense, liability or loss
under the Delaware General Corporation Law.

         SECTION 6.  INDEMNIFICATION OF EMPLOYEES AND AGENTS OF THE CORPORATION.

         The Corporation may, to the extent authorized from time to time by the
Board of Directors, grant rights to indemnification and to the advancement of
expenses to any employee or agent of the Corporation to the fullest extent of
the provisions of this Article with respect to the indemnification and
advancement of expenses of directors and officers of the Corporation.


                       ARTICLE VIII - CERTAIN TRANSACTIONS

        SECTION 1.   TRANSACTIONS WITH INTERESTED PARTIES.

        No contract or transaction between the Corporation and one or more of
its directors or officers, or between the Corporation and any other corporation,
partnership, association, or other organization in which one or more of its
directors or officers are directors or officers, or have a financial interest,
shall be void or voidable solely for this reason, or solely because the director
or officer is present at or participates in the meeting of the Board or
committee thereof which authorizes the contract or transaction or solely because
the votes of such director or officer are counted for such purpose, if:

                (a) The material facts as to his or her relationship or interest
        and as to the contract or transaction are disclosed or are known to the
        Board of Directors or the committee, and the Board or committee in good
        faith authorizes the contract or transaction by the affirmative votes of
        a majority of the disinterested directors, even though the disinterested
        directors be less than a quorum; or

                (b) The material facts as to his or her relationship or interest
        and as to the contract or transaction are disclosed or are known to the
        stockholders entitled to vote thereon, and the contract or transaction
        is specifically approved in good faith by vote of the stockholders; or

                (c) The contract or transaction is fair as to the Corporation as
        of the time it is authorized, approved or ratified, by the Board of
        Directors, a committee thereof, or the stockholders.

        SECTION 2.   QUORUM.

        Common or interested directors may be counted in determining the
presence of a quorum at a meeting of the Board of Directors or of a committee
which authorizes the contract or transaction.

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<PAGE>

                           ARTICLE IX - MISCELLANEOUS

        SECTION 1.  FACSIMILE SIGNATURES.

        In addition to the provisions for use of facsimile signatures elsewhere
specifically authorized in these Bylaws, facsimile signatures of any officer or
officers of the Corporation may be used whenever and as authorized by the Board
of Directors or a committee thereof.

        SECTION 2.  CORPORATE SEAL.

        The Board of Directors may provide a suitable seal, containing the name
of the Corporation, which seal shall be in the charge of the Secretary. If and
when so directed by the Board of Directors or a committee thereof, duplicates of
the seal may be kept and used by the Treasurer or by an Assistant Secretary or
Assistant Treasurer.

        SECTION 3.  RELIANCE UPON BOOKS, REPORTS AND RECORDS.

        Each director, each member of any committee designated by the Board of
Directors, and each officer of the Corporation shall, in the performance of his
or her duties, be fully protected in relying in good faith upon the books of
account or other records of the Corporation and upon such information, opinions,
reports or statements presented to the Corporation by any of its officers or
employees, or committees of the Board of Directors so designated, or by any
other person as to matters which such director or committee member reasonably
believes are within such other person's professional or expert competence and
who has been selected with reasonable care by or on behalf of the Corporation.

        SECTION 4.  FISCAL YEAR.

        Except as otherwise determined by the Board of Directors from time to
time, the fiscal year of the Corporation shall end on the last day of December
of each year.

        SECTION 5.  TIME PERIODS.

        In applying any provision of these Bylaws which requires that an act be
done or not be done a specified number of days prior to an event or that an act
be done during a period of a specified number of days prior to an event,
calendar days shall be used, the day of the doing of the act shall be excluded,
and the day of the event shall be included.

        SECTION 6.  PRONOUNS.

        Whenever the context may require, any pronouns used in these Bylaws
shall include the corresponding masculine, feminine or neuter forms.

                                       17
<PAGE>

                             ARTICLE X - AMENDMENTS

         These Bylaws may be amended or repealed by the affirmative vote of a
majority of the whole Board or by the stockholders by the affirmative vote of
seventy percent (70%) of the outstanding voting power of the then-outstanding
shares of capital stock of the Corporation, entitled to vote generally in the
election of directors, at any meeting at which a proposal to amend or repeal
these Bylaws is properly presented.




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