VARIAGENICS INC
10-Q, EX-10.1, 2000-09-01
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THIS WARRANT AND THE SHARES OF CAPITAL STOCK ISSUED UPON ANY EXERCISE HEREOF
HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
"SECURITIES ACT"), OR ANY APPLICABLE STATE SECURITIES LAWS AND MAY NOT BE SOLD
OR OTHERWISE TRANSFERRED BY ANY PERSON, INCLUDING A PLEDGEE, UNLESS (1) EITHER
(A) A REGISTRATION WITH RESPECT TO THERETO SHALL BE EFFECTIVE UNDER THE
SECURITIES ACT, OR (B) THE COMPANY SHALL HAVE RECEIVED AN OPINION OF COUNSEL
SATISFACTORY TO THE COMPANY THAT AN EXEMPTION FROM REGISTRATION UNDER THE
SECURITIES ACT IS AVAILABLE, AND (2) THERE SHALL HAVE BEEN COMPLIANCE WITH ALL
APPLICABLE STATE SECURITIES OR "BLUE SKY" LAWS.

No. W0001                                                       For the Purchase
                                                                of 80,357 shares
                                                                 of Common Stock


                            WARRANT TO PURCHASE STOCK

                                       OF

                                Variagenics, Inc.

                            (A DELAWARE CORPORATION)

         Variagenics, Inc., a Delaware corporation (the "Company"), for value
received, hereby certifies that Waters Investments Limited (the "Holder"), is
entitled, subject to the terms set forth below, to purchase from the Company, at
any time or from time to time on or after July 26, 2000 and at or before the
earlier of 5:00 p.m. Eastern Standard time on the "Expiration Date" and the
termination of this Warrant as provided in Section 7 hereof, 80,357 shares of
Common Stock, par value $.01 per share, of the Company (the "Common Stock"), at
a purchase price per share equal to the "Base Price" subject to adjustment of
the Base Price upon the occurrence of certain events as set forth in Section 3
of this Warrant. The "Expiration Date" shall be July 26, 2005. The "Base Price"
shall initially be equal to the per share offering Price to Public set forth on
the cover page of the final Prospectus (as defined below). The shares of stock
issuable upon exercise of this Warrant, and the Base Price, as adjusted, are
hereinafter referred to as the "Warrant Stock" and the "Purchase Price,"
respectively. On March 29, 2000, the Company filed with the United States
Securities and Exchange Commission ("SEC") a Registration Statement on Form S-1
(No. 333-33558) ("Registration Statement") with respect to an initial public
offering of shares of its Common Stock. The term "Prospectus" as used herein
shall mean the prospectus, as amended, on file with the SEC at the time the
Registration Statement becomes effective, including the information deemed to be
part of the Registration Statement at the time of effectiveness pursuant to Rule
430A, if applicable, except that if the prospectus filed by the Company pursuant
to Rule 424(b) differs from the prospectus on file at the time the Registration
Statement becomes effective, the



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term "Prospectus" shall refer to the Rule 424(b) Prospectus from and after the
time it was filed with the SEC or transmitted to the SEC for filing.

         1.       EXERCISE.

                  1.1   MANNER OF EXERCISE; PAYMENT OF PURCHASE PRICE. This
         Warrant may be exercised by the Holder, in whole or in part, by
         surrendering this Warrant, with the purchase form appended hereto as
         Exhibit A duly executed by the Holder, at the principal office of the
         Company, or at such other place as the Company may designate,
         accompanied by payment in full of the Purchase Price payable in respect
         of the number of shares of Warrant Stock purchased upon such exercise.
         Payment of the Purchase Price shall be (i) in lawful money of the
         United States, in cash or by certified or official bank check payable
         to the order of the Company, in respect of the number of shares of
         Warrant Stock purchased upon such exercise or (ii) in accordance with
         subsection 1.4 below.

                  1.2   EFFECTIVENESS. Each exercise of this Warrant shall be
         deemed to have been effected immediately prior to the close of business
         on the day on which this Warrant shall have been surrendered to the
         Company as provided in Section 1.1 above. At such time, the person or
         persons in whose name or names any certificates for Warrant Stock shall
         be issuable upon such exercise as provided in Section 1.3 below shall
         be deemed to have become the holder or holders of record of the Warrant
         Stock represented by such certificates.

                  1.3.   DELIVERY OF CERTIFICATES. As soon as practicable after
         the exercise of this Warrant in full or in part, and in any event
         within ten (10) business days thereafter, the Company at its sole
         expense will cause to be issued in the name of, and delivered to, the
         Holder, or, subject to the terms and conditions hereof, as such Holder
         (upon payment by such Holder of any applicable transfer taxes) may
         direct:

                           (a) A certificate or certificates for the number of
                  full shares of Warrant Stock to which such Holder shall be
                  entitled upon such exercise plus, in lieu of any fractional
                  share to which such Holder would otherwise be entitled, cash
                  in an amount determined pursuant to Section 2 hereof, and

                           (b) In case such exercise is in part only, a new
                  warrant or warrants (dated the date hereof) of like tenor,
                  calling in the aggregate on the face or faces thereof for the
                  number of shares of Warrant Stock (without giving effect to
                  any adjustment therein) equal to the number of such shares
                  called for on the face of this Warrant minus either (i) the
                  number of such shares purchased by the Holder upon exercise as
                  provided in Section 1.1 above or (ii) the number of shares for
                  which this Warrant is exercised plus the number of shares for
                  which the right to exercise this Warrant is surrendered upon
                  exercise pursuant to Section 1.4 below.

                  1.4   CASHLESS EXERCISE. The Holder may elect to receive,
         without the payment by the Holder of any additional consideration,
         shares equal to the value of this Warrant or



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         any portion hereof then exercised by the surrender of this Warrant or
         such portion to the Company, with the net issue election notice
         appended hereto as Exhibit B duly executed, at the office of the
         Company. Thereupon, the Company shall issue to the Holder such number
         of fully paid and nonassessable shares of Common Stock as is computed
         using the following formula:

                                   X = Y (A-B)
                                       -------
                                        A
         where

                  X = the number of shares to be issued to the Holder pursuant
                     to this subsection 1.4.

                  Y = the  number of shares covered by this Warrant in respect
                     of which the net issue election is made pursuant to this
                     subsection 1.4.

                  A = the Fair Market Value of one share of Common Stock (as
                     defined in and determined in accordance with Section 1.5
                     hereof) as at the time the net issue election is made
                     pursuant to this subsection 1.4.

                  B = the Purchase Price in effect under this Warrant at the
                     time the net issue election is made pursuant to this
                     subsection 1.4.

                  1.5   FAIR MARKET VALUE OF COMMON STOCK. Fair Market Value of
a share of Common Stock means: (1) if the Common Stock is listed on a national
securities exchange or traded in the over-the-counter market and sales prices
are regularly reported for the Common Stock, the closing or last price of the
Common Stock on the Composite Tape or other comparable reporting system for the
trading day immediately preceding the applicable date; (2) if the Common Stock
is not traded on a national securities exchange but is traded on the
over-the-counter market, if sales prices are not regularly reported for the
Common Stock for the trading day referred to in clause (1), and if bid and asked
prices for the Common Stock are regularly reported, the mean between the bid and
the asked price for the Common Stock at the close of trading in the
over-the-counter market for the trading day on which Common Stock was traded
immediately preceding the applicable date; and (3) if the Common Stock is
neither listed on a national securities exchange nor traded in the
over-the-counter market, such value as reasonably determined in good faith by
the Board of Directors of the Company. The Board of Directors of the Company
shall promptly respond in writing to an inquiry by the Holder as to the Fair
Market Value of one share of Common Stock.

        2.        FRACTIONAL SHARES. The Company shall not be required upon
the exercise of this Warrant to issue any fractional shares, but shall make an
adjustment therefor in cash on the basis of the Fair Market Value of the Warrant
Stock as determined pursuant to Section 1.5 hereof.



                                       3

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         3.       ADJUSTMENTS.

                  3.1.   CHANGES IN COMMON STOCK. If the Company shall (i)
         combine the outstanding shares of Common Stock into a lesser number of
         shares, (ii) subdivide the outstanding shares of Common Stock into a
         greater number of shares, or (iii) issue additional shares of Common
         Stock as a dividend or other distribution with respect to the Common
         Stock, the number of shares of Warrant Stock shall be equal to the
         number of shares which the Holder would have been entitled to receive
         after the happening of any of the events described above if such
         shares had been issued immediately prior to the happening of such
         event, such adjustment to become effective concurrently with the
         effectiveness of such event. The Purchase Price in effect immediately
         prior to any such combination of Common Stock shall, upon the
         effectiveness of such combination, be proportionately increased. The
         Purchase Price in effect immediately prior to any such subdivision of
         Common Stock or at the record date of such dividend shall upon the
         effectiveness of such subdivision or immediately after the record date
         of such dividend be proportionately reduced.

                  3.2   REORGANIZATIONS AND RECLASSIFICATIONS. If there shall
         occur any capital reorganization or reclassification of the Common
         Stock (other than a change in par value or a subdivision or combination
         as provided for in Section 3.1), which terms shall be deemed to
         include, without limitation, any merger of the Company with or into any
         other entity in which either (i) the Company is the surviving
         corporation and the sole consideration (if any) delivered to the
         stockholders of the Company consists of equity securities of the
         Company, (ii) the Company is not the surviving corporation and the sole
         consideration delivered to the stockholders of the Company consists of
         equity securities of the surviving corporation, or (iii) a merger the
         sole purpose of which is to change the state of incorporation of the
         Company, then, as part of any such reorganization or reclassification,
         lawful provision shall be made so that the Holder shall have the right
         thereafter to receive upon the exercise hereof the kind and amount of
         shares of stock or other securities or property which such Holder would
         have been entitled to receive if, immediately prior to any such
         reorganization or reclassification, such Holder had held the number of
         shares of Common Stock which were then purchasable upon the exercise of
         this Warrant. In any such case, appropriate adjustment (as reasonably
         determined by the Board of Directors of the Company) shall be made in
         the application of the provisions set forth herein with respect to the
         rights and interests thereafter of the Holder such that the provisions
         set forth in this Section 3 (including provisions with respect to
         adjustment of the Purchase Price) shall thereafter be applicable, as
         nearly as is reasonably practicable, in relation to any shares of stock
         or other securities or property thereafter deliverable upon the
         exercise of this Warrant.

                  3.3   [INTENTIONALLY OMITTED.]

                  3.4   CERTIFICATE OF ADJUSTMENT. When any adjustment is
         required to be made in the Purchase Price, the Company shall promptly
         mail to the Holder a certificate setting forth the Purchase Price
         after such adjustment and setting forth a brief statement of the
         facts



                                       4

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         requiring such adjustment. Delivery of such certificate shall be
         deemed to be a final and binding determination with respect to such
         adjustment unless challenged by the Holder within ten (10) days of
         receipt thereof. Such certificate shall also set forth the kind and
         amount of stock or other securities or property into which this
         Warrant shall be exercisable following the occurrence of any of the
         events specified in this Section 3.

         4.       COMPLIANCE WITH SECURITIES ACT.

                  4.1   UNREGISTERED SECURITIES. The Holder acknowledges that
         this Warrant and the Warrant Stock have not been registered under the
         Securities Act of 1933, as amended, and the rules and regulations
         thereunder, or any successor legislation (the "Securities Act"), and
         agrees not to sell, pledge, distribute, offer for sale, transfer or
         otherwise dispose of this Warrant or any Warrant Stock in the absence
         of (i) an effective registration statement under the Securities Act
         covering this Warrant or such Warrant Stock and registration or
         qualification of this Warrant or such Warrant Stock under any
         applicable "blue sky" or state securities law then in effect, or (ii)
         an opinion of counsel, satisfactory to the Company, that such
         registration and qualification are not required. The Company may delay
         issuance of the Warrant Stock until completion of any action or
         obtaining of any consent, which the Company deems necessary under any
         applicable law (including without limitation state securities or "blue
         sky" laws).

                  4.2   INVESTMENT LETTER. Without limiting the generality of
         Section 4.1, unless the offer and sale of any shares of Warrant Stock
         shall have been effectively registered under the Securities Act, the
         Company shall be under no obligation to issue the Warrant Stock unless
         and until the Holder shall have executed an investment letter in form
         and substance satisfactory to the Company, including a warranty at the
         time of such exercise that the Holder is acquiring such shares for its
         own account, for investment and not with a view to, or for sale in
         connection with, the distribution of any such shares.

                  4.3   LEGEND. Certificates delivered to the Holder pursuant to
         Section 1.3 shall bear the following legend or a legend in
         substantially similar form:

                  "THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE BEEN TAKEN
                  FOR INVESTMENT AND THEY MAY NOT BE SOLD OR OTHERWISE
                  TRANSFERRED BY ANY PERSON, INCLUDING A PLEDGEE, IN THE ABSENCE
                  OF AN EFFECTIVE REGISTRATION STATEMENT FOR THE SHARES UNDER
                  THE SECURITIES ACT OF 1933, AS AMENDED, OR AN OPINION OF
                  COUNSEL, SATISFACTORY TO THE COMPANY, THAT AN EXEMPTION FROM
                  REGISTRATION IS THEN AVAILABLE."

         5.       RESERVATION OF STOCK. The Company will at all times reserve
and keep available, solely for issuance and delivery upon the exercise of
this Warrant, such shares of Warrant Stock and other stock, securities and
property, as from time to time shall be issuable upon the exercise of


                                       5
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this Warrant. The Company covenants that all shares of Warrant Stock so issuable
will, when issued, be duly and validly issued and fully paid and nonassessable.

         6.       REPLACEMENT OF WARRANTS. Upon receipt of evidence reasonably
satisfactory to the Company of the loss, theft, destruction or mutilation of
this Warrant and (in the case of loss, theft or destruction) upon delivery of an
indemnity agreement (with surety if reasonably required) in an amount reasonably
satisfactory to the Company, or (in the case of mutilation) upon surrender and
cancellation of this Warrant, the Company will issue, in lieu thereof, a new
Warrant of like tenor.

         7.       TERMINATION UPON CERTAIN EVENTS. In the event of a sale of
all or substantially all of the assets of the Company to, or a merger or
consolidation of the Company with or into, any other entity (other than (i) a
merger in which the Company is the surviving corporation and the sole
consideration (if any) delivered to the stockholders of the Company consists of
equity securities of the Company, (ii) a merger in which the Company is not the
surviving corporation and the sole consideration delivered to the stockholders
of the Company consists of equity securities of the surviving corporation, or
(iii) a merger the sole purpose of which is to change the state of
incorporation of the Company) or a dissolution or the adoption of a plan of
liquidation of the Company, the Company shall give the Holder notice of any
such sale, merger, consolidation, dissolution or adoption at least 30 days
prior to the effective date of any sale, merger, consolidation, dissolution or
adoption (the "Effective Date"). If this Warrant shall not have otherwise
terminated or expired, the Holder shall have the right until 5:00 p.m, Eastern
Standard Time, on the day immediately prior to the Effective Date to exercise
its rights hereunder to the extent not previously exercised, but may make such
exercise conditional upon the consummation of any such transaction on the
Effective Date. In the event that the Holder does not exercise or give notice
to the Company of its intent not to exercise its rights hereunder prior to the
Effective Date, the Holder shall be deemed to have exercised its right to
exercise this Warrant in whole pursuant to Section 1.4 hereof and shall be
treated as if Holder had exercised this Warrant in whole under such Section 1.4
at the close of business on the day immediately prior to the Effective Date,
and upon the delivery of the cash or other property due to the Holder under
Section 1.4 hereof, this Warrant shall terminate.

         8.       TRANSFERABILITY. Without the prior written consent of the
Company, the Warrant shall not be assigned, pledged or hypothecated in any way
(whether by operation of law or otherwise) and shall not be subject to
execution, attachment or similar process; provided, however, that this Warrant
may be transferred without consent to any 100% Affiliate of the Holder. Any
attempted transfer, assignment, pledge, hypothecation or other disposition of
the Warrant or of any rights granted hereunder contrary to the provisions of
this Section 8, or the levy of any attachment or similar process upon the
Warrant or such rights, shall be null and void. For the purposes of this
Section 8, "100% Affiliate" shall mean any company, corporation, business or
entity controlled by, controlling, or under common control with either party to
this Agreement. For this purpose, "control" means direct or indirect beneficial
ownership of a one hundred percent (100%) interest in the voting stock (or the
equivalent) of such corporation or other business.

         9.       NO RIGHTS AS STOCKHOLDER. Until the exercise of this Warrant,
the Holder shall not have or exercise any rights by virtue hereof as a
stockholder of the Company.



                                      6



<PAGE>

         10.      LOCK-UP AGREEMENT. If, in connection with a registration
statement filed by the Company pursuant to the Securities Act with respect to
an underwritten public offering, the Company or its underwriter so requests,
Holder agrees not to sell or otherwise transfer or dispose of any of the Warrant
Stock for a period not to exceed one hundred and eighty (180) days following the
effectiveness of such registration, and to enter into an agreement to such
effect; provided that all of (i) the Company's directors and officers, (ii) the
holders of at least 2% of the outstanding Common Stock (or securities
convertible into at least 2% of the Common Stock), and (iii) the other holders
of securities of the Company participating in the underwriting enter into
similar agreements. The Company may impose stop-transfer instructions with
respect to the Shares subject to the foregoing restriction until the end of said
period.

         11.      NOTICES. All notices, requests and other communications
hereunder shall be in writing, shall be either (i) delivered by hand, (ii) made
by, telecopy or facsimile transmission, (iii) sent by overnight courier, or
(iv) sent by registered mail, postage prepaid, return receipt requested. In the
case of notices from the Company to the Holder, they shall be sent to the
address furnished to the Company in writing by the last Holder who shall have
furnished an address to the Company in writing. All notices from the Holder to
the Company shall be delivered to the Company at its principal offices or such
other address as the Company shall so notify the Holder. All notices, requests
and other communications hereunder shall be deemed to have been given (i) by
hand, at the time of the delivery thereof to the receiving party at the address
of such party described above, (ii) if made by telecopy or facsimile
transmission, at the time that receipt thereof has been acknowledged by
electronic confirmation or otherwise, (iii) if sent by overnight courier, on
the next business day following the day such notices is delivered to the
courier service, or (iv) if sent by registered mail, on the fifth business day
following the day such mailing is made.

         12.      WAIVERS AND MODIFICATIONS. Any term or provision of this
Warrant may be waived only by written document executed by the party entitled
to the benefits of such terms or provisions. The terms and provisions of this
Warrant may be modified or amended only by written agreement executed by the
parties hereto.

         13.      HEADINGS. The headings in this Warrant are for convenience of
reference only and shall in no way modify or affect the meaning or construction
of any of the terms or provisions of this Warrant.

         14.      GOVERNING LAW. This Warrant will be governed by and construed
in accordance with and governed by the law of the Commonwealth of
Massachusetts, without giving effect to the conflict of law principles
thereof.


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                                               Variagenics, Inc.


                                               By:
                                                  -----------------------------
                                               Name:    Taylor J. Crouch
                                               Title:   President


[Corporate Seal]
ATTEST:

----------------------------




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                                    EXHIBIT A

                                  PURCHASE FORM
                                  -------------

To:      Variagenics, Inc.

         The undersigned pursuant to the provisions set forth in the attached
Warrant (No. W-0001), hereby irrevocably elects to purchase ______ shares of the
Common Stock, par value $.01 per share (the "Common Stock") of Variagenics,
Inc., covered by such Warrant and herewith makes payment of $__________,
representing the full purchase price for such shares at the price per share
provided for in such Warrant. The Common Stock for which the Warrant may be
exercised shall be known herein as the "Warrant Stock".

         The undersigned is aware that the Warrant Stock has not been and will
not be registered under the Securities Act of 1933, as amended (the "Securities
Act") or any state securities laws. The undersigned understands that reliance by
the Company on exemptions under the Securities Act is predicated in part upon
the truth and accuracy of the statements of the undersigned in this Purchase
Form.

         The undersigned represents and warrants that (1) it has been furnished
with all information which it deems necessary to evaluate the merits and risks
of the purchase of the Warrant Stock, (2) it has had the opportunity to ask
questions concerning the Warrant Stock and the Company and all questions posed
have been answered to its satisfaction, (3) it has been given the opportunity to
obtain any additional information it deems necessary to verify the accuracy of
any information obtained concerning the Warrant Stock and the Company and (4) it
has such knowledge and experience in financial and business matters that it is
able to evaluate the merits and risks of purchasing the Warrant Stock and to
make an informed investment decision relating thereto.

         The undersigned hereby represents and warrant that it is purchasing the
Warrant Stock for its own account for investment and not with a view to the sale
or distribution of all or any part of the Warrant Stock.

         The undersigned understands that because the Warrant Stock has not been
registered  under the Securities Act, it must continue to bear the economic risk
of the investment for an indefinite  period of time and the Warrant Stock cannot
be sold unless it is subsequently  registered under applicable federal and state
securities laws or an exemption from such registration is available.

         The undersigned agrees that it will in no event sell or distribute or
otherwise dispose of all or any part of the Warrant Stock unless (1) there is an
effective registration statement under the Securities Act and applicable state
securities laws covering any such transaction involving the Warrant Stock, or
(2) the Company receives an opinion satisfactory to the Company of the
undersigned's legal counsel stating that such transaction is exempt from
registration. The


                                       9

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undersigned consents to the placing of a legend on its certificate for the
Warrant Stock stating that the Warrant Stock has not been registered and setting
forth the restriction on transfer contemplated hereby and to the placing of a
stop transfer order on the books of the Company and with any transfer agents
against the Warrant Stock until the Warrant Stock may be legally resold or
distributed without restriction.

         The undersigned has considered the federal and state income tax
implications of the exercise of the Warrant and the purchase and subsequent sale
of the Warrant Stock.




                                            -----------------------------------

                                            Dated:
                                                  -----------------------------





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                                                                      EXHIBIT B
                                                                      ---------

                            NET ISSUE ELECTION NOTICE
                            -------------------------

To:   Variagenics, Inc.                               Dated:
                                                            --------------------


      The undersigned hereby elects to exercise Warrant No. 0001 for ___ shares
of Common Stock and hereby elects under Subsection 1.4 to surrender the right to
purchase _________ shares of Common Stock pursuant to said Warrant. The
certificate(s) for the shares issuable upon such net issue election shall be
issued in the name of the undersigned or as otherwise indicated below.

      The undersigned is aware that the Warrant Stock has not been and will not
be registered under the Securities Act of 1933, as amended (the "Securities
Act") or any state securities laws. The undersigned understands that reliance by
the Company on exemptions under the Securities Act is predicated in part upon
the truth and accuracy of the statements of the undersigned in this Purchase
Form.

      The undersigned represents and warrants that (1) it has been furnished
with all information which it deems necessary to evaluate the merits and risks
of the purchase of the Warrant Stock, (2) it has had the opportunity to ask
questions concerning the Warrant Stock and the Company and all questions posed
have been answered to its satisfaction, (3) it has been given the opportunity to
obtain any additional information it deems necessary to verify the accuracy of
any information obtained concerning the Warrant Stock and the Company and (4) it
has such knowledge and experience in financial and business matters that it is
able to evaluate the merits and risks of purchasing the Warrant Stock and to
make an informed investment decision relating thereto.

      The undersigned hereby represents and warrant that it is purchasing the
Warrant Stock for its own account for investment and not with a view to the sale
or distribution of all or any part of the Warrant Stock.

      The undersigned understands that because the Warrant Stock has not been
registered under the Securities Act, it must continue to bear the economic risk
of the investment for an indefinite period of time and the Warrant Stock cannot
be sold unless it is subsequently registered under applicable federal and state
securities laws or an exemption from such registration is available.



                                       11

<PAGE>


      The undersigned agrees that it will in no event sell or distribute or
otherwise dispose of all or any part of the Warrant Stock unless (1) there is an
effective registration statement under the Securities Act and applicable state
securities laws covering any such transaction involving the Warrant Stock, or
(2) the Company receives an opinion satisfactory to the Company of the
undersigned's legal counsel stating that such transaction is exempt from
registration. The undersigned consents to the placing of a legend on its
certificate for the Warrant Stock stating that the Warrant Stock has not been
registered and setting forth the restriction on transfer contemplated hereby and
to the placing of a stop transfer order on the books of the Company and with any
transfer agents against the Warrant Stock until the Warrant Stock may be legally
resold or distributed without restriction.

      The undersigned has considered the federal and state income tax
implications of the exercise of the Warrant and the purchase and subsequent sale
of the Warrant Stock.



                                    ---------------------------------------
                                    Signature


                                    ---------------------------------------
                                    Name for Registration


                                    ---------------------------------------
                                    Mailing Address









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