<PAGE>
As filed with the Securities and Exchange Commission on October 18, 2000
REGISTRATION NO. 333-
================================================================================
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
---------------------
FORM S-8
REGISTRATION STATEMENT
UNDER THE
SECURITIES ACT OF 1933
---------------------
VARIAGENICS, INC.
(EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)
<TABLE>
<S> <C>
DELAWARE 04-3182077
(STATE OR OTHER JURISDICTION (I.R.S. EMPLOYER
OF INCORPORATION OR ORGANIZATION) IDENTIFICATION NO.)
</TABLE>
60 HAMPSHIRE STREET
CAMBRIDGE, MASSACHUSETTS 02139
(617) 588-5300
(ADDRESS OF PRINCIPAL EXECUTIVE OFFICES)
VARIAGENICS, INC. AMENDED 1997 EMPLOYEE, DIRECTOR AND
CONSULTANT STOCK OPTION PLAN
(FULL TITLES OF THE PLANS)
TAYLOR J. CROUCH
PRESIDENT AND CHIEF EXECUTIVE OFFICER
VARIAGENICS, INC.
60 HAMPSHIRE STREET
CAMBRIDGE, MASSACHUSETTS 02139
(617) 588-5300
(NAME, ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER, INCLUDING AREA
CODE, OF AGENT FOR SERVICE)
---------------------
<TABLE>
<CAPTION>
CALCULATION OF REGISTRATION FEE
===================================================================================================================================
Proposed Proposed
Title of Amount to be Maximum Maximum
securities to be registered registered (1) offering price Aggregate Amount of
per share (2) offering price (2) Registration fee
-----------------------------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C>
Common Stock, $.01 par value 2,957,475 shares $ 2.34 $ 6,913,713 $1,825
1,656,728 shares $ 14.25 $ 23,608,374 $6,233
========= ============= ======
4,614,203 shares $ 30,522,087 $8,058
===================================================================================================================================
</TABLE>
(1) The number of shares of common stock, par value $.01 per share ("Common
Stock") stated above consists of the aggregate number of shares which may
be sold upon the exercise of options which have been granted and/or may
hereafter be granted under the Variagenics, Inc. Amended 1997 Employee,
Director and Consultant Stock Option Plan (the "Plan"). The maximum number
of shares that may be sold upon the exercise of such options granted under
the Plan are subject to adjustment in accordance with certain anti-dilution
and other provisions of the Plan. Accordingly, pursuant to Rule 416 under
the Securities Act of 1933, as amended (the "Securities Act"), this
Registration Statement covers, in addition to the number of shares stated
above, an indeterminate number of shares which may be subject to grant or
otherwise issuable after the operation of any such anti-dilution and other
provisions.
(2) This calculation is made solely for the purpose of determining the
registration fee pursuant to the provisions of Rule 457(c) and (h)(1) under
the Securities Act as follows: (i) in the case of shares of Common Stock
which may be purchased upon exercise of outstanding options, the fee is
calculated on the basis of the price at which the options may be exercised;
and (ii) in the case of shares of Common Stock for which options have not
yet been granted and the option price of which is therefore unknown, the
fee is calculated on the basis of the average of the high and low sale
prices per share of the Common Stock on the National Market System of the
National Association of Securities Dealers Automated Quotation System
(NASDAQ) as of a date (October 13, 2000) within 5 business days prior to
filing this Registration Statement.
================================================================================
<PAGE>
EXPLANATORY NOTE
In accordance with the instructional Note to Part I of Form S-8 as
promulgated by the Securities and Exchange Commission, the information specified
by Part I of Form S-8 has been omitted from this Registration Statement on Form
S-8 for offers of Common Stock pursuant to the Plan.
<PAGE>
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
ITEM 3. INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE.
The following documents filed by the Registrant with the Commission are
incorporated herein by reference:
(1) The Registrant's prospectus dated July 21, 2000 filed with the
Commission pursuant to Rule 424(b) of the Securities Act in connection with the
Registrant's Registration Statement on Form S-1 (No. 333-33558).
(2) The Registrant's Quarterly Report on Form 10-Q for the quarter
ended June 30, 2000 (File No. 0-31035) filed with the Commission pursuant to the
Securities Exchange Act of 1934, as amended (the "Exchange Act").
(3) The description of the Common Stock contained in the
Registrant's Registration Statement on Form 8-A (File No.0-31035) filed under
the Exchange Act including any amendment or report filed for the purpose of
updating such description.
All reports and other documents filed by the Registrant after the date
hereof pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act
prior to the filing of a post-effective amendment which indicates that all
securities offered hereby have been sold or which deregisters all securities
then remaining unsold, shall be deemed to be incorporated by reference herein
and to be part hereof from the date of filing of such reports and documents.
ITEM 4. DESCRIPTION OF SECURITIES.
Not applicable.
ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL.
The validity of the issuance of the shares of Common Stock registered
under this Registration Statement has been passed upon for the Registrant by
Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. of Boston, Massachusetts.
Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. and members of that firm own
an aggregate of approximately 32,243 shares of Common Stock of the Registrant.
ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS.
Incorporated herein by reference from Registration Statement on Form
S-1, No. 333-33558.
ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED.
Not applicable.
II-1
<PAGE>
ITEM 8. EXHIBITS.
(3.1) Restated Certificate of Incorporation of the Registrant (Filed
as Exhibit 3.2 to the Registrant's Registration Statement on
Form S-1, as amended, No. 333-33558, and incorporated herein
by reference).
(3.2) Restated By-laws of the Registrant (Filed as Exhibit 3.4 to
the Registrant's Registration Statement on Form S-1, as
amended, No. 333-33558, and incorporated herein by reference).
(4.1) Form of Common Stock Certificate (Filed as Exhibit 4.1 to the
Registrant's Registration Statement on Form S-1, as amended,
No. 333-33558, and incorporated herein by reference).
(5) Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
as to the legality of shares being registered.
(23.1) Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
(included in opinion of counsel filed as Exhibit 5).
(23.2) Consent of PricewaterhouseCoopers LLP.
(24) Power of Attorney (included on the signature page of this
Registration Statement).
(99.1) Variagenics, Inc. Amended 1997 Employee, Director and
Consultant Stock Option Plan.
(99.2) Form of Incentive Stock Option Agreement.
(99.3) Form of Non-Qualified Stock Option Agreement.
ITEM 9. UNDERTAKINGS.
(a) The undersigned Registrant hereby undertakes:
(1) To file, during any period in which offers or sales are being made,
a post-effective amendment to this Registration Statement:
(i) To include any prospectus required by Section
10(a)(3) of the Securities Act of 1933;
(ii) To reflect in the prospectus any facts or events
arising after the effective date of the Registration Statement
(or the most recent post-effective amendment thereof) which,
individually or in the aggregate, represents a fundamental
change in the information set forth in the Registration
Statement. Notwithstanding the foregoing, any increase or
decrease in volume of securities offered (if the total dollar
value of securities offered would not exceed that which was
registered) and any deviation from the low or high end of the
estimated maximum offering range may be reflected in the form
of prospectus filed with the Commission pursuant to Rule
424(b) if, in the aggregate, the changes in volume and
II-2
<PAGE>
price represent no more than a 20% change in the maximum
aggregate offering price set forth in the "Calculation
of Registration Fee" table in the effective Registration
Statement;
(iii) To include any material information with
respect to the plan of distribution not previously disclosed
in the Registration Statement or any material change to such
information in the Registration Statement;
PROVIDED, HOWEVER, that paragraphs (a)(1)(i) and (a)(1)(ii) do
not apply if the Registration Statement is on Form S-3 or Form S-8, and
the information required to be included in a post-effective amendment
by those paragraphs is contained in periodic reports filed by the
Registrant pursuant to Section 13 or Section 15(d) of the Securities
Exchange Act of 1934 that are incorporated by reference in this
Registration Statement.
(2) That, for the purpose of determining any liability under the
Securities Act of 1933, each such post-effective amendment shall be
deemed to be a new registration statement relating to the securities
offered therein, and the offering of such securities at that time shall
be deemed to be the initial bona fide offering thereof.
(3) To remove from registration by means of a post-effective amendment
any of the securities being registered which remain unsold at the
termination of the offering.
(b) The undersigned Registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing
of the Registrant's annual report pursuant to Section 13(a) or Section
15(d) of the Securities Exchange Act of 1934 that is incorporated by
reference in this Registration Statement shall be deemed to be a new
registration statement relating to the securities offered therein, and
the offering of such securities at that time shall be deemed to be the
initial bona fide offering thereof.
(c) Insofar as indemnification for liabilities arising under the Securities
Act of 1933 may be permitted to directors, officers and controlling
persons of the Registrant pursuant to the foregoing provisions, or
otherwise, the Registrant has been advised that in the opinion of the
Securities and Exchange Commission such indemnification is against
public policy as expressed in the Act and is, therefore, unenforceable.
In the event that a claim for indemnification against such liabilities
(other than the payment by the Registrant of expenses incurred or paid
by a director, officer or controlling person of the Registrant in the
successful defense of any action, suit or proceeding) is asserted by
such director, officer or controlling person in connection with the
securities being registered, the Registrant will, unless in the opinion
of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Act
and will be governed by the final adjudication of such issue.
II-3
<PAGE>
SIGNATURES
THE REGISTRANT. Pursuant to the requirements of the Securities Act of
1933, the Registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in Cambridge, Massachusetts on October 18, 2000.
VARIAGENICS, INC.
By /s/ Taylor J. Crouch
------------------------------------
Taylor J. Crouch
President and Chief Executive Officer
Each person whose signature appears below constitutes and appoints
Taylor J. Crouch and Richard P. Shea, and each of them, his or her true and
lawful attorneys-in-fact and agents, with full power of substitution and
resubstitution in each of them, for him and in his name, place and stead, and in
any and all capacities, to sign any and all amendments (including post-effective
amendments) to this Registration Statement on Form S-8 of Variagenics, Inc., and
to file the same, with all exhibits thereto and other documents in connection
therewith, with the Securities and Exchange Commission, granting unto said
attorneys-in-fact and agents, and each of them, full power and authority to do
and perform each and every act and thing requisite or necessary to be done in or
about the premises, as full to all intents and purposes as he or she might or
could do in person, hereby ratifying and confirming all that said
attorneys-in-fact and agents or any of them or their or his or her substitute or
substitutes may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.
<TABLE>
<CAPTION>
SIGNATURES TITLE DATE
<S> <C> <C>
/s/ Taylor J. Crouch
----------------------------------------- President, Chief Executive Officer October 18, 2000
Taylor J. Crouch and Director (Principal executive officer)
/s/ Richard P. Shea
----------------------------------------- Chief Financial Officer and Treasurer October 18, 2000
Richard P. Shea (Principal financial and accounting officer)
/s/ David Housman, Ph.D.
----------------------------------------- Director October 18, 2000
David Housman, Ph.D.
/s/ Philippe O. Chambon, M.D., Ph.D.
----------------------------------------- Director October 18, 2000
Philippe O. Chambon, M.D., Ph.D.
</TABLE>
II-4
<PAGE>
<TABLE>
<S> <C> <C>
/s/ Jean-Francois Formela, M.D.
----------------------------------------- Director October 18, 2000
Jean-Francois Formela, M.D.
/s/ Martin A. Vogelbaum
----------------------------------------- Director October 18, 2000
Martin A. Vogelbaum
/s/ William A. Scott, Ph.D.
----------------------------------------- Director October 18, 2000
William A. Scott, Ph.D.
/s/ Anthony Wild, Ph.D.
----------------------------------------- Director October 18, 2000
Anthony Wild, Ph.D.
</TABLE>
II-5
<PAGE>
VARIAGENICS, INC.
INDEX TO EXHIBITS FILED WITH
FORM S-8 REGISTRATION STATEMENT
EXHIBIT
NUMBER DESCRIPTION
(3.1) Restated Certificate of Incorporation of the Registrant (Filed as
Exhibit 3.2 to the Registrant's Registration Statement on Form S-1, as
amended, No. 333-33558, and incorporated herein by reference).
(3.2) Restated By-Laws of the Registrant (Filed as Exhibit 3.4 to the
Registrant's Registration Statement on Form S-1, as amended, No.
333-33558, and incorporated herein by reference).
(4.1) Form of Common Stock Certificate (Filed as Exhibit 4.1 to Registration
Statement on Form S-1, as amended, No. 333-33558, and incorporated
herein by reference).
(5) Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to
the legality of shares being registered.
(23.1) Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
(included in opinion of counsel filed as Exhibit 5).
(23.2) Consent of PricewaterhouseCoopers LLP.
(24) Power of Attorney (included on the signature page of this Registration
Statement).
(99.1) Variagenics, Inc. Amended 1997 Employee, Director and Consultant Stock
Option Plan.
(99.2) Form of Incentive Stock Option Agreement.
(99.3) Form of Non-Qualified Stock Option Agreement.
II-6