TRANSGENOMIC INC
S-1, 2000-03-10
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<PAGE>
     AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MARCH 10, 2000

                                                    REGISTRATION NO. 333-
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                                ----------------

                                    FORM S-1
                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933
                                ----------------

                               TRANSGENOMIC, INC.
             (Exact name of Registrant as specified in its charter)

<TABLE>
<S>                                              <C>                          <C>
           DELAWARE                                         3826                    91-1789357
   (State of incorporation)                           (Primary standard          (I.R.S. employer
                                                         industrial            identification no.)
                                                 classification code number)
</TABLE>

                             5600 SOUTH 42ND STREET
                             OMAHA, NEBRASKA 68107
                                 (402) 738-5480

  (Address, including zip code, and telephone number, including area code, of
                   Registrant's principal executive offices)

                               COLLIN J. D'SILVA
                      Chairman and Chief Executive Officer
                             5600 South 42nd Street
                             Omaha, Nebraska 68107
                                 (402) 738-5480
 (Name, address, including zip code, and telephone number, including area code,
                             of agent for service)

                Please address a copy of all communications to:

<TABLE>
<S>                    <C>
STEVEN P. AMEN, ESQ.          ROBERT B. WILLIAMS, ESQ.
   Kutak Rock LLP       Milbank, Tweed, Hadley & McCloy LLP
 1650 Farnam Street          One Chase Manhattan Plaza
Omaha, Nebraska 68102         New York, New York 10005
   (402) 346-6000                  (212) 530-5000
</TABLE>

                                 --------------

        APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: As soon
as practicable on or after the effective date of this Registration Statement.

        If any of the securities being registered on this Form are to be offered
on a delayed or continuous basis pursuant to Rule 415 under the Securities Act
of 1933, check the following box. [ ]

        If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, check the following box and
list the Securities Act registration statement number of the earlier effective
registration statement for the same offering. [ ]

        If this Form is a post-effective amendment filed pursuant to
Rule 462(c) under the Securities Act, check the following box and list the
Securities Act registration statement number of the earlier effective
registration statement for the same offering. [ ]

        If this Form is a post-effective amendment filed pursuant to
Rule 462(d) under the Securities Act, check the following box and list the
Securities Act registration statement number of the earlier effective
registration statement for the same offering. [ ]

        If delivery of the prospectus is expected to be made pursuant to
Rule 434, check the following box. [ ]

                        CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>
                                                           PROPOSED MAXIMUM     PROPOSED MAXIMUM
      TITLE OF EACH CLASS OF              AMOUNT TO         OFFERING PRICE          AGGREGATE            AMOUNT OF
    SECURITIES TO BE REGISTERED       BE REGISTERED(1)       PER SHARE(2)       OFFERING PRICE(2)    REGISTRATION FEE
<S>                                  <C>                  <C>                  <C>                  <C>
Common Stock, par value $0.01
  share............................       4,600,000             $14.00             $64,400,000            $17,002
</TABLE>

(1) Includes 600,000 shares of Common Stock that the Underwriters have the
    option to purchase solely to cover over-allotments, if any.

(2) Estimated solely for the purpose of calculating the registration fee.
                               ------------------

        THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL
FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION
STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE SECURITIES ACT OF 1933 OR UNTIL THIS REGISTRATION STATEMENT SHALL BECOME
EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(A),
MAY DETERMINE.

- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
<PAGE>
                  SUBJECT TO COMPLETION, DATED MARCH 10, 2000

THE INFORMATION IN THIS PROSPECTUS IS NOT COMPLETE AND MAY BE CHANGED. WE MAY
NOT SELL THESE SECURITIES UNTIL THE REGISTRATION STATEMENT FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION BECOMES EFFECTIVE. THIS PROSPECTUS IS NOT AN
OFFER TO SELL THESE SECURITIES AND IT IS NOT SOLICITING OFFERS TO BUY THESE
SECURITIES IN ANY JURISDICTION WHERE THE OFFER OR SALE IS NOT PERMITTED.
<PAGE>
PROSPECTUS

                                4,000,000 SHARES

                                     [LOGO]

                                  COMMON STOCK

    This is an initial public offering of common stock by Transgenomic, Inc. We
are selling 4,000,000 shares of common stock. The estimated initial public
offering price is between $12.00 and $14.00 per share.

                                 --------------

    Prior to this offering, there has been no public market for our common
stock. We have applied for listing of our common stock on the Nasdaq National
Market under the symbol TBIO.

                                 --------------

<TABLE>
<CAPTION>
                                                              PER SHARE      TOTAL
                                                              ---------   -----------
<S>                                                           <C>         <C>
Initial public offering price...............................   $          $
Underwriting discounts and commissions......................   $          $
Proceeds to Transgenomic, before expenses...................   $          $
</TABLE>

    Transgenomic has granted the underwriters an option for a period of 30 days
to purchase up to 600,000 additional shares of common stock.

                                 --------------

         INVESTING IN THE COMMON STOCK INVOLVES A HIGH DEGREE OF RISK.
                    SEE "RISK FACTORS" BEGINNING ON PAGE 6.

                                 -------------

    NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES
COMMISSION HAS APPROVED OR DISAPPROVED OF THESE SECURITIES OR PASSED UPON THE
ADEQUACY OR ACCURACY OF THIS PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY IS A
CRIMINAL OFFENSE.

CHASE H&Q

                 BEAR, STEARNS & CO. INC.

                                  DAIN RAUSCHER WESSELS

           , 2000
<PAGE>
The inside front cover of the prospectus contains a graphic depiction of DNA
analysis using the WAVESystem. The various steps of a sample analysis described
in the picture include the following:

SEPARATION

        The DNA separation, analysis, and collection processes performed on our
instrument are completely automated. The DNASep Column is key to our process. A
sample is placed into our DNASep Column and DNA fragments are separated
according to size, mutation, or other properties. The process can be analytical
or if pure DNA material is desired the separation can be performed on a
preparative basis.

3 MODES OF OPERATION

        DNA can be separated according to three different modes. Changing the
temperature at which DNA is separated on the DNASep Column controls these modes.
Sizing of double strand DNA is performed at lower temperatures. Mutant DNA is
separated at intermediate temperatures where DNA is partially denatured or
melted. Single strand DNA and RNA are separated at higher temperatures.

DETECTION AND ANALYSIS

        DNA fragments flow from the DNASep Column directly into a detection and
measurement device. The type and amount of DNA material is identified using two
different detection measurements. UV detection is used for most applications.
Fluorescence detection is used when measurement of very small amounts of DNA is
desired.

COLLECTION

        If desired, highly purified DNA can be collected by our fragment
collector. Purified DNA can be used for cloning, sequencing, PCR, or in any
process where purified fragments of DNA are needed. Cloning, for example, is
much more efficient if a highly purified fragment is used in the cloning
process.
<PAGE>
                               TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                PAGE
                                                              --------
<S>                                                           <C>
Prospectus Summary..........................................      1
Risk Factors................................................      6
Forward-Looking Statements..................................     13
Use of Proceeds.............................................     14
Dividend Policy.............................................     14
Capitalization..............................................     15
Dilution....................................................     16
Selected Financial Data.....................................     18
Management's Discussion and Analysis of Financial Condition
  and Results of Operations.................................     19
Business....................................................     24
Management..................................................     35
Principal Stockholders......................................     41
Related Party Transactions..................................     43
Description of Capital Stock................................     44
Shares Eligible for Future Sale.............................     48
U.S. Federal Tax Considerations for Non-U.S. Holders........     50
Underwriting................................................     54
Legal Matters...............................................     56
Experts.....................................................     56
Where You Can Find More Information.........................     56
Index to Financial Statements...............................    F-1
</TABLE>

    THIS PROSPECTUS CONTAINS REFERENCES TO OUR REGISTERED TRADEMARKS
WAVE-REGISTERED TRADEMARK- AND DNASEP-REGISTERED TRADEMARK-. WAVEMAKER-TM-, WAVE
OPTIMIZED-TM- AND THE TRANSGENOMIC NAME AND THE TRANSGENOMIC LOGO ARE OUR
TRADEMARKS FOR WHICH REGISTRATION APPLICATIONS HAVE BEEN FILED WITH THE UNITED
STATES PATENT AND TRADEMARK OFFICE. ALL OTHER TRADEMARKS OR TRADE NAMES REFERRED
TO IN THIS PROSPECTUS ARE THE PROPERTY OF THEIR RESPECTIVE OWNERS.
<PAGE>
                               PROSPECTUS SUMMARY

        THE SUMMARY HIGHLIGHTS SELECTED INFORMATION CONTAINED ELSEWHERE IN THIS
PROSPECTUS. THIS SUMMARY DOES NOT CONTAIN ALL THE INFORMATION YOU SHOULD
CONSIDER BEFORE INVESTING IN OUR COMMON STOCK. YOU SHOULD READ THE ENTIRE
PROSPECTUS CAREFULLY, INCLUDING "RISK FACTORS" AND OUR CONSOLIDATED HISTORICAL
AND PRO FORMA FINANCIAL STATEMENTS AND THE NOTES TO THOSE FINANCIAL STATEMENTS
BEGINNING ON PAGE F-1, BEFORE MAKING AN INVESTMENT DECISION.

                                  TRANSGENOMIC

OUR BUSINESS

        We provide innovative research tools to the life sciences industry.
These tools enable researchers to discover and understand variation in the human
genetic code, or genome, in order to accelerate and improve drug development and
diagnostics. We believe our WAVE System, which incorporates our proprietary
DNASep separation column and associated software, consumables and reagents, will
become a leading tool to analyze genetic mutations. The WAVE System allows
researchers to analyze both known and unknown genetic mutations faster, with
more accuracy and at a lower cost than other commercially available techniques.
As of March 1, 2000, we have sold over 240 WAVE Systems in 20 countries to
academic research centers and biopharmaceutical companies. In 1999, sales of our
WAVE Systems and related consumables accounted for approximately $14 million in
revenues.

        As efforts to sequence the human genome near completion, understanding
genetic variation, or mutation analysis, is becoming the vital link to the
development of new drug products and diagnostics. These genetic mutations can
include single nucleotide polymorphisms, or SNPs, among others. By comparing
genetic mutations in the genome to the occurrence of diseases or particular
traits, correlations can be made between genes and specific diseases or traits.
Our WAVE System, unlike tools employing more conventional technologies, can
detect these genetic mutations without previous knowledge of their existence or
position. As a result, the WAVE System provides researchers a more accurate and
efficient means of performing the experiments necessary to identify mutations
and to correlate the relationships between mutations and diseases.

OUR TECHNOLOGY AND PRODUCTS

        Our WAVE System is designed to perform high-speed, automated analyses of
DNA molecules to identify the type, location and frequency of DNA mutations,
with a high degree of accuracy and consistency. The WAVE System is based on our
proprietary micro-bead technology. Our patented micro-beads are packed into our
proprietary DNASep separation column, which is the key component of our WAVE
System. Each micro-bead has specific surface chemistry that interacts with DNA
molecules. The DNA molecules are then selectively separated from the micro-beads
with a mixture of our liquid reagents. This process is automated by our
proprietary WAVEMaker Software for analysis and interpretation.

CUSTOMERS

        Our customers include numerous core laboratory facilities and a number
of other leading academic and medical institutions in the U.S. and abroad,
including Harvard University, Stanford University, Baylor University, University
of Chicago, Fred Hutchison Cancer Research Facility, Mayo Clinic, National
Cancer Institute, National Institutes of Health, Institut Curie, University of
Cambridge, Wellcome Trust-Oxford University and Institut Gustave Roussy.
Customers also include a number of large, established U.S. and foreign
pharmaceutical and biotech companies including SmithKline Beecham,
Bristol-Meyers Squibb, Millennium Pharmaceuticals, Merck & Company, Novartis and
Eli Lilly and Company.

                                       1
<PAGE>
OUR STRATEGY

        We intend to be the leading provider of technology platforms which
enable life sciences researchers to discover and understand variations in the
human genome, in order to accelerate and improve drug development and
diagnostics. Key elements of this strategy include:

        - FOCUS ON THE GENETIC VARIATION DISCOVERY MARKET;

        - ESTABLISH THE WAVE SYSTEM AS THE INDUSTRY STANDARD;

        - INCREASE CONSUMABLE SALES;

        - PENETRATE NEW MARKETS BY PROVIDING A DIVERSIFIED PORTFOLIO OF
          PRODUCTS; AND

        - BUILD A SUBSTANTIAL INTELLECTUAL PROPERTY ESTATE.

RECENT DEVELOPMENTS

        We were incorporated in Delaware on March 6, 1997 for the purpose of
conducting our DNA separation and analysis business, in addition to the non-life
sciences businesses which were being conducted by CETAC Holding Company, Inc.
and its subsidiaries, CETAC Technologies, Inc., Sarasep, Inc. and Interaction
Chromatography, Inc. On July 1, 1997, we merged CETAC Holding Company, Inc. and
its subsidiaries into Transgenomic.

        We have since decided to focus our resources on our life sciences
business. We have recently entered into a letter of intent to sell the assets
related to our non-life sciences instrument product line and expect this sale to
close prior to the closing of this offering.

        Our principal office is located at 5600 South 42nd Street, Omaha,
Nebraska 68107 (telephone: 402-738-5480). We maintain manufacturing facilities
and our principal research and development office in San Jose, California
(telephone: 408-432-3230). Our website is located at
http://www.transgenomic.com. The information contained in our website is not
part of this prospectus, and you should rely only on the information contained
in this prospectus in deciding whether to invest in our common stock.

                                       2
<PAGE>
                                  THE OFFERING

<TABLE>
<S>                                                           <C>
Common stock offered........................................  4,000,000 shares

Common stock to be outstanding after this offering..........  20,037,200 shares

Use of proceeds.............................................  For expansion of manufacturing
                                                              capacity, sales and marketing costs,
                                                              research and development costs, debt
                                                              reduction and general working
                                                              capital. See "Use of Proceeds."

Proposed Nasdaq National Market symbol......................  TBIO
</TABLE>

                          ----------------------------

The number of shares to be outstanding after this Offering includes all shares
outstanding as of March 10, 2000 plus 2,712,200 shares that will be issued upon
the assumed conversion of $12.0 million aggregate principal amount of our
convertible notes plus accrued interest at $5.00 per share, and 300,000 shares
that will be issued at $5.00 per share upon the exercise of warrants that will
expire at the closing of this offering.

The number of shares to be outstanding after this offering does not include the
following:

        - 152,450 shares issuable upon exercise of outstanding warrants with an
          exercise price of $5.00 per share;

        - 6,000,000 shares that we could issue under our employee stock option
          plan. As of the date of this prospectus, we have issued options to
          purchase 3,724,250 shares of common stock at an exercise price ranging
          from $5.00 to $10.00 per share, except that options to acquire 15,000
          shares of common stock issued to one of our non-employee directors may
          be exercised at a price equal to the lower of $5.00 or 50% of the
          public offering price for this offering. We may issue options to
          acquire up to 2,275,750 additional shares of our common stock under
          this plan; and

        - an undetermined number of additional shares we are obligated to issue
          to some of our existing stockholders if the public offering price for
          this offering is less than $10.00 per share. The number of additional
          shares we will have to issue will depend on the offering price. In
          addition, we will have to adjust the number of shares we will have to
          issue upon exercise of the warrants and conversion of the notes
          described above if the public offering price for this offering is less
          than $10.00 per share.

                          ----------------------------

UNLESS OTHERWISE INDICATED, INFORMATION IN THIS PROSPECTUS:

        - ASSUMES THAT THE UNDERWRITERS DO NOT EXERCISE THEIR OVERALLOTMENT
          OPTION; AND

        - ASSUMES THE INITIAL PUBLIC OFFERING PRICE OF OUR COMMON STOCK WILL BE
          $13.00 PER SHARE.

                                       3
<PAGE>
                 SUMMARY CONSOLIDATED HISTORICAL FINANCIAL DATA

        The summary consolidated historical financial data for our 1997, 1998
and 1999 fiscal years is derived from our consolidated financial statements for
these years. You should read this summary data along with "Management's
Discussion and Analysis of Financial Condition and Results of Operations," our
consolidated financial statements and the unaudited pro forma financial
information, and the related notes thereto, included elsewhere in this
prospectus.

<TABLE>
<CAPTION>
                                                                   YEAR ENDED DECEMBER 31,
                                                              ---------------------------------
                                                                1997        1998        1999
                                                              ---------   ---------   ---------
                                                               (IN THOUSANDS, EXCEPT PER SHARE
                                                                            DATA)
<S>                                                           <C>         <C>         <C>
STATEMENTS OF OPERATIONS DATA:
  Net sales.................................................   $11,577     $18,935     $23,035
  Gross profit..............................................     5,241       9,345      10,945
  Operating expenses........................................     8,459      11,320      17,829
  Loss from operations......................................    (3,218)     (1,975)     (6,884)
  Net loss..................................................   $(2,410)    $(1,576)    $(9,827)
  Basic and diluted loss per share..........................   $ (0.22)    $ (0.13)    $ (0.76)
  Basic and diluted weighted average shares
    outstanding(1)..........................................    11,145      12,279      13,000
</TABLE>

<TABLE>
<CAPTION>
                                                                         AS OF DECEMBER 31,
                                                                         -------------------
                                                                           1998       1999
                                                                         --------   --------
                                                                           (IN THOUSANDS)
<S>                                                           <C>        <C>        <C>
BALANCE SHEET DATA:
  Working capital...........................................             $ 1,845    $ 3,494
  Total assets..............................................              14,736     19,964
  Long-term debt, less current portion......................                 695     12,538
  Stockholders' equity (deficit)............................               6,649     (2,099)
</TABLE>

- ------------------------

(1)  See Note A of notes to our consolidated financial statements for an
     explanation of the determination of the number of shares used in computing
    per share data.

                                       4
<PAGE>
                   SUMMARY UNAUDITED PRO FORMA FINANCIAL DATA

        The following summary unaudited pro forma statement of operations data
for the year ended December 31, 1999 reflects the sale of assets related to our
non-life sciences instrument product line (Transgenomic as adjusted) and the
issuance of 300,000 shares of common stock at $5.00 per share upon the exercise
of warrants that will expire at the closing of this offering, as if each had
occurred on January 1, 1999, and the assumed conversion at $5.00 per share of
our outstanding convertible notes and accrued interest into 2,712,200 shares of
common stock as of March 23, 1999, the date the convertible notes were issued.
The summary unaudited pro forma balance sheet data reflects these transactions
and the sale of 25,000 shares of common stock at $10.00 per share in March 2000
as if each had been completed on December 31, 1999.

        The pro forma as adjusted balance sheet data additionally reflects the
sale of 4,000,000 shares of common stock offered by us in this offering at an
assumed initial public offering price of $13.00 per share, less underwriting
discounts and commissions and estimated offering expenses. The unaudited pro
forma financial data are intended for informational purposes only and are not
intended to be indicative of our results of operations or financial position had
these transactions occurred on the dates specified, nor are they indicative of
our future results of operations or financial position.

        You should read this summary along with our consolidated financial
statements and notes thereto, our unaudited pro forma financial information and
notes thereto, "Management's Discussion and Analysis of Financial Condition and
Results of Operations" and "Use of Proceeds" included elsewhere in this
prospectus.

<TABLE>
<CAPTION>
                                                   YEAR ENDED DECEMBER 31, 1999
                              -----------------------------------------------------------------------
                                             ADJUSTMENTS FOR
                                                 SALE OF
                                                NON-LIFE                      ADJUSTMENTS
                                                SCIENCES                          FOR
                              TRANSGENOMIC     INSTRUMENT      TRANSGENOMIC   CONVERTIBLE
                              (HISTORICAL)    PRODUCT LINE     AS ADJUSTED       NOTES      PRO FORMA
                              ------------   ---------------   ------------   -----------   ---------
                                               (IN THOUSANDS, EXCEPT PER SHARE DATA)
<S>                           <C>            <C>               <C>            <C>           <C>
STATEMENT OF OPERATIONS
  DATA:
Net sales...................    $ 23,035         $  8,794        $ 14,241            --     $ 14,241
Gross profit................      10,945            3,869           7,076            --        7,076
Operating expenses..........      17,829            3,576          14,253            --       14,253
Loss from operations........      (6,884)             293          (7,177)           --       (7,177)
Other expense...............      (1,198)              --          (1,198)          859         (339)
Loss before income taxes....      (8,082)             293          (8,375)          859       (7,516)
Net loss....................    $ (9,827)        $    293        $(10,120)      $   859     $ (9,261)
Basic and diluted loss per
  share.....................    $  (0.76)                        $  (0.78)                  $  (0.60)
Basic and diluted weighted
  average shares
  outstanding...............      13,000                           13,000                     15,334
</TABLE>

<TABLE>
<CAPTION>
                                                                   AS OF DECEMBER 31, 1999
                                                              ----------------------------------
                                                                                      PRO FORMA
                                                               ACTUAL    PRO FORMA   AS ADJUSTED
                                                              --------   ---------   -----------
                                                                        (IN THOUSANDS)
<S>                                                           <C>        <C>         <C>
BALANCE SHEET DATA:
Working capital.............................................  $ 3,494     $ 8,523      $55,883
Total assets................................................   19,964      21,914       69,274
Long-term debt, less current portion........................   12,538         117          117
Stockholders' equity (deficit)..............................   (2,099)     12,385       59,745
</TABLE>

                                       5
<PAGE>
                                  RISK FACTORS

        YOU SHOULD CONSIDER CAREFULLY THE FOLLOWING RISK FACTORS AND ALL OTHER
INFORMATION CONTAINED IN THIS PROSPECTUS BEFORE PURCHASING OUR COMMON STOCK.
INVESTING IN OUR COMMON STOCK INVOLVES A HIGH DEGREE OF RISK. ANY OF THE
FOLLOWING RISKS COULD HARM OUR BUSINESS, FINANCIAL CONDITION AND RESULTS OF
OPERATIONS AND COULD RESULT IN A COMPLETE LOSS OF YOUR INVESTMENT.

                         RISKS RELATED TO OUR BUSINESS

OUR LIMITED OPERATING HISTORY AS A COMPANY FOCUSED ON LIFE SCIENCES TECHNOLOGIES
AND APPLICATIONS SUBJECTS US TO RISKS INHERENT IN THE DEVELOPMENT OF A NEW
BUSINESS ENTERPRISE.

        We have a limited operating history as a company focused on life
sciences technologies and applications and are at a relatively early stage of
development in this business. Our future financial performance will depend on
the growth in demand for automated DNA separation and analysis enabling
technologies. The genomics market is new and emerging, is rapidly evolving, is
characterized by an increasing number of market entrants, and will be subject to
frequent and continuing changes in standards, customers' preferences and
technology. As a result, our business is subject to all of the risks inherent in
the development of a new business enterprise, such as the need:

        - to develop a market for our products;

        - to obtain enough capital to support the expenses of developing and
          commercializing our products; and

        - to attract and retain qualified management, sales, technical and
          scientific staffs.

        We expect that it will be a number of years, if ever, before we will
achieve profitability from the sale of our products. Our future operating
results will depend on a number of factors, including the market acceptance of
our products, the introduction of new products by our competitors, our ability
to adapt our technology to the commercial needs of our customers and to
developments in the genomics industry, and the timing and extent of our research
and development efforts. Our limited operating history in the life sciences
industry makes accurate prediction of future operations difficult. If our
operating results fail to meet the expectations of securities analysts or
investors, our stock price could decline.

WE HAVE A HISTORY OF OPERATING LOSSES AND EXPECT TO INCUR LOSSES IN THE FUTURE.

        We experienced losses from operations of $6.9 million in 1999,
$2.0 million in 1998 and $3.2 million in 1997. These losses were mostly due to
research and development expenses and sales and marketing expenses related to
the development and marketing of our WAVE System. As of December 31, 1999, we
had an accumulated deficit of $12.3 million. In order to continue to enhance our
WAVE System and related products, develop new products, increase the pace of
installations and expand our marketing, sales and customer support service
staffs, we expect to incur significant increases in our expenses over the next
several years. As a result, we could continue to incur losses for the forseeable
future and may never be profitable.

OUR TECHNOLOGY AND PRODUCTS ARE RELATIVELY NEW AND MAY NOT GAIN MARKET
ACCEPTANCE AMONG GENOMICS RESEARCHERS.

        Our WAVE System and other automated DNA separation and analysis products
are relatively new products and have had limited use in commercial applications.
As a result, it is possible that previously unrecognized defects could emerge.
We have developed our WAVE System technology for a number of applications in the
area of life sciences research. We may not be able to successfully adapt our
products to the commercial requirements of these fields. A number of potential
uses of our WAVE System

                                       6
<PAGE>
in these fields will require significant enhancements in its technology,
including adaptation of our software. Increased market acceptance of our
products is dependent upon factors, some of which are not in our control, such
as continued growth in the genomics industry, the availability and price of
competing products and technologies, the success of our sales efforts, and the
acceptance of our product by the academic and research community, such as
biologists, geneticists and biochemists, who are more familiar with the
existing, traditional methods of DNA separation and analysis. Our products must
compete against well-established techniques, such as gel and capillary
electrophoresis and sequencing-based technologies. We cannot be certain that our
products will replace or compete successfully against existing products or that
our products will achieve market acceptance. If we are unable, for technological
or other reasons, to complete the development, introduction or scale-up of our
product manufacturing, or if our products do not achieve market acceptance, our
business could be seriously harmed.

IF ETHICAL AND OTHER CONCERNS SURROUNDING THE USE OF GENETIC INFORMATION BECOME
WIDESPREAD, WE MAY HAVE LESS DEMAND FOR OUR PRODUCTS.

        Genetic testing has raised ethical issues regarding confidentiality and
the appropriate uses of the resulting information. For these reasons,
governmental authorities may call for limits on or regulation of the use of
genetic testing or prohibit testing for genetic predisposition to certain
conditions, particularly for those that have no known cure. Any of these
scenarios could reduce the potential markets for our products, which could
seriously harm our business.

WE HAVE A LIMITED SALES FORCE AND LIMITED EXPERIENCE WITH DIRECT MARKETING OF
OUR PRODUCTS WHICH COULD LIMIT OUR ABILITY TO EFFECTIVELY PENETRATE NEW MARKETS.

        Our direct sales force may not be sufficiently large or knowledgeable to
successfully penetrate the market. We may not be able to expand our direct sales
force to meet our commercial objectives. In addition, our sales force may not be
able to address complex scientific and technical issues raised by our customers.
Our customer support personnel may also lack the broad range of technical
expertise required to adequately service and support our products in the field.

THE SALE OF OUR PRODUCTS INVOLVES A LENGTHY SALES CYCLE WHICH MAKES OUR REVENUES
DIFFICULT TO FORECAST.

        Our ability to obtain customers for our WAVE System and related
accessories depends in large part on the perception that our products can help
accelerate basic genomics research, diagnostic testing and related applications
such as drug discovery and development efforts. The purchase of a WAVE System
often represents a large capital outlay for potential customers, who are often
constrained by limited research budgets. Additionally, the sales cycle is long
due to the need to educate potential customers as to the benefits and use of our
WAVE System. We also need to effectively communicate the benefits of our WAVE
System to a variety of constituencies within potential customer groups,
including research and development personnel and key management. We may expend
substantial funds and sales effort with no assurance that a sale will result.
Due to the lengthy sales cycle required, our revenues could be difficult to
forecast.

OUR BUSINESS MAY EXPERIENCE LONG COLLECTION PERIODS WHICH COULD HAVE A NEGATIVE
IMPACT ON OUR LIQUIDITY.

        We have experienced in the past, and may experience in the future,
collection periods of up to a year or more in connection with sales of our WAVE
System. Some customers delay payment due to the large capital outlay associated
with a purchase of the WAVE System. Other clients in the academic and research
fields are accustomed to longer payment periods than commercial buyers. In
general, our overseas customers pay less promptly than is customary in the
United States. In addition, because we are in the early stages of
commercialization of the WAVE System, we sometimes agree to provide extended

                                       7
<PAGE>
payment terms in order to make a sale. Longer collection periods may have a
negative impact on our liquidity.

WE MAY NEED TO RAISE ADDITIONAL FUNDING WHICH MAY NOT BE AVAILABLE.

        We have historically financed our operations primarily through debt and
equity financings, including offerings of common stock, convertible notes and
bank financings. We will continue to need substantial amounts of cash for
research and development and to expand our sales and marketing infrastructure.
We expect our capital and operating expenses to increase over the next several
years as we expand this infrastructure and our research and development
activities. The amount of additional capital which we will need to raise will
depend on many factors, including:

        - the level of our research and development activities;

        - market acceptance of our products and technologies;

        - the level of our sales and marketing expenses;

        - expenditures in connection with alliances and license agreements and
          in acquiring new businesses and technologies;

        - costs incurred in enforcing and defending our patent claims and other
          intellectual property rights; and

        - the cost of financing the purchase of additional capital equipment and
          development tools.

        We may need to raise the additional capital in the future through bank
financings or strategic investments. Additional financing may not be available
to us when we need it, or, if available, we cannot assure that we will be able
to obtain such financing on terms favorable to us or our stockholders. If we
raise additional capital by issuing equity securities, the issuance of such
securities would result in ownership dilution to our stockholders.

OUR WAVE SYSTEM INCLUDES HARDWARE COMPONENTS AND INSTRUMENTS MANUFACTURED BY A
SINGLE SUPPLIER AND IF WE WERE NO LONGER ABLE TO OBTAIN THESE COMPONENTS AND
INSTRUMENTS OUR BUSINESS COULD BE HARMED.

        We currently rely on a single supplier, Hitachi Instruments, Inc., to
provide the basic instrument used in our WAVE System. While other suppliers of
instrumentation and computer hardware are available, we believe that our
arrangement with Hitachi offers strategic advantages. If we were required to
seek alternative sources of supply, it could be time consuming or expensive or
require significant and costly modification of our WAVE System. Also, if we were
unable to obtain instruments from Hitachi in sufficient quantities or in a
timely manner, our ability to supply our products could be impaired, which could
harm our business.

OUR CHROMATOGRAPHIC COLUMNS, A CORE COMPONENT OF THE WAVE SYSTEM, ARE
MANUFACTURED AT A SINGLE FACILITY WHICH IS LOCATED IN AN EARTHQUAKE-PRONE AREA.

        All of our proprietary DNASep columns are manufactured at our
manufacturing facility in San Jose, California, which is located in an
earthquake-prone area. In the event our manufacturing facility or equipment was
affected by man-made or natural disasters, we would be unable to manufacture our
products for sale or meet customer demand or sales projections. If our
manufacturing operations were curtailed or ceased, it would seriously harm our
business.

                                       8
<PAGE>
WE FACE, AND WILL CONTINUE TO FACE, INTENSE COMPETITION, BOTH IN THE U.S. AND
ABROAD, FROM COMPANIES THAT ARE ENGAGED IN THE DEVELOPMENT OF PRODUCTS THAT
ANALYZE DNA AND PROVIDE GENETIC INFORMATION.

        The market for our products is highly competitive. Our principal
competitors include other biotechnology companies that provide alternative
technologies and products for the separation and analysis of DNA. Many of our
competitors have greater financial, operational, sales and marketing resources
and more experience in research and development and commercialization than we
have. Moreover, some of our competitors have greater name recognition than we do
and provide more conventional technologies and products with which some of our
customers and potential customers may have more familiarity or experience. In
order to effectively compete against alternative technologies we will need to
demonstrate the superior performance, speed, capabilities and cost effectiveness
of our WAVE System.

        The genomics industry is characterized by extensive research efforts and
rapid technological progress. To remain competitive, we will be required to
continue to expand and enhance the functionality of our DNA separation and
analysis equipment and to offer comprehensive DNA analysis, and complimentary
applications and solutions, with greater ease of use. This will include the need
to increase the WAVE System's throughput capacity and to develop new
instrumentation, software and application kits to allow the system to provide a
broader range of DNA and RNA separation and analysis applications. New products
may require additional development work, enhancement, testing, or further
refinement before they can be made commercially available and, therefore, we
could experience significant delays in the development and manufacture of our
products. Even after new products are made commercially available, unforeseen
technical difficulties could arise, requiring additional expenditures by us to
correct such difficulties and possibly resulting in further delays. We cannot be
certain that new products will be successfully developed at all. If our products
have performance, reliability or quality shortcomings, then we may experience
reduced orders, higher development costs, delays in collecting accounts
receivable and additional warranty and service expenses, and our reputation as a
reliable provider of quality products could be harmed. In addition, new
developments are expected to continue in DNA analysis, and we cannot assure you
that our WAVE System will not be made obsolete by more effective or less
expensive technologies. Because of rapid technological change, we may be
required to expend greater amounts in the development of new products, which in
turn will require greater revenues to recoup such expenditures. We cannot assure
you that we will be able to make the necessary enhancements to our technology or
products to compete successfully with new technologies that may emerge.

WE ARE IN THE PROCESS OF SELLING THE ASSETS RELATED TO OUR NON-LIFE SCIENCES
INSTRUMENT PRODUCT LINE WHICH HAVE HISTORICALLY CONTRIBUTED TO OUR REVENUES AND
EARNINGS.

        In addition to our DNA separation and analysis products, we have
produced and sold various non-life sciences products. Until 1999, most of our
revenues and profits came from these non-life sciences products. We have
recently decided to focus our resources on our new automated DNA separation and
analysis products and technologies and have decided to sell the assets related
to our non-life sciences product line. As a result, we will no longer generate
revenues from the sale of these products. The future growth of our company will
be entirely dependent on the sale of our WAVE System and associated DNA
separation products and technologies. You should keep this fact in mind when
reviewing our financial statements. Because of the change in our product
offerings, our historic financial statements will not necessarily indicate our
future financial performance.

WE MAY EXPERIENCE DIFFICULTY IN COLLECTING ACCOUNTS RECEIVABLE FROM CUSTOMERS OF
OUR NON-LIFE SCIENCES INSTRUMENT PRODUCT LINE AFTER ITS SALE.

        We expect to sell assets related to our non-life sciences instrument
product line prior to the completion of this offering. The agreement for the
sale is expected to provide that we will retain all accounts receivable
outstanding as of the date of the sale. Our accounts receivable associated with
sales from this product line were approximately $1.5 million at December 31,
1999. After the sale, we may

                                       9
<PAGE>
experience difficulty in collecting the remaining accounts receivable due to the
lack of a continuing relationship with some customers.

OUR PATENTS MAY NOT PROTECT US FROM OTHERS USING OUR TECHNOLOGY WHICH COULD HARM
OUR BUSINESS AND COMPETITIVE POSITION.

        Our business and competitive position are dependent upon our ability to
protect our proprietary technology. While we currently hold a number of domestic
and foreign patents and licenses, the issuance of a patent is not conclusive as
to its validity or enforceability, nor does it provide the patent holder with
freedom to operate without infringing the patent rights of others. Our patents
or licenses could be challenged by litigation and, if the outcome of such
litigation were adverse to us, our competitors could be free to use our
technology. As a result, the invalidation of key patents owned by or licensed to
us or non-approval of pending patent applications could increase competition and
materially harm our business.

        We may not be able to obtain additional patents for our technology, or
if we are able to do so, patents may not provide us with substantial protection
or be commercially beneficial. Our patent applications may not protect our
products because of the following reasons:

        - we cannot be certain that any of our pending patent applications will
          result in additional issued patents;

        - we may develop additional proprietary technologies that are not
          patentable;

        - we cannot be certain that any patents issued or licensed to us will
          provide a basis for commercially viable products;

        - we cannot be certain that any patents issued or licensed to us will
          not be challenged or circumvented or invalidated by third parties; and

        - we cannot be certain that any patents issued to others will not have
          an adverse effect on our ability to do business.

        Patent law relating to the scope of claims in the technology fields in
which we operate is still evolving. The degree of future protection for our
proprietary rights is uncertain. Furthermore, we cannot be certain that others
will not independently develop similar or alternative products or technology,
duplicate any of our products, or, if patents are issued to us, design around
the patented products developed by us. In addition, we could incur substantial
costs in litigation if we are required to defend ourselves in patent suits
brought by third parties or if we initiate such suits.

WE CANNOT BE CERTAIN THAT OTHER MEASURES TAKEN TO PROTECT OUR INTELLECTUAL
PROPERTY WILL BE EFFECTIVE.

        We rely upon trade secret protection, copyright and trademark laws,
non-disclosure agreements and other contractual provisions for some of our
confidential and proprietary information that is not subject matter for which
patent protection is being sought. Such measures, however, may not provide
adequate protection for our trade secrets or other proprietary information. If
they do not protect our rights, third parties could use our technology and our
ability to compete in the market would be reduced. While we require employees,
academic collaborators and consultants to enter into confidentiality and/or
intellectual property assignments where appropriate, any of the following could
still occur:

        - proprietary information could be disclosed or others may gain access
          to such information;

        - others may independently develop substantially equivalent proprietary
          information and techniques;

        - we may not have adequate remedies for any breach; or

        - we may not be able to meaningfully protect our trade secrets.

                                       10
<PAGE>
WE ARE DEPENDENT UPON OUR LICENSED TECHNOLOGIES AND MAY NEED TO OBTAIN
ADDITIONAL LICENSES IN THE FUTURE TO OFFER OUR PRODUCTS AND REMAIN COMPETITIVE.

        We have acquired or licensed key components of our technologies from
third parties. If these agreements were to terminate prematurely or if we breach
the terms of any licenses or otherwise fail to maintain our rights to such
technology, it could harm our business. In addition, we may need to obtain
licenses to additional technologies in the future in order to keep our products
competitive. Failure to license or otherwise acquire necessary technologies
could harm our business, financial condition and results of operations.

THE PROTECTION OF INTELLECTUAL PROPERTY IN FOREIGN COUNTRIES IS UNCERTAIN.

        We have sold approximately 50% of our WAVE Systems to customers located
outside the U.S. The patent and other intellectual property laws of some foreign
countries may not protect our intellectual property rights to the same extent as
U.S. laws. We may need to bring proceedings to defend our patent rights or to
determine the validity of our competitors' foreign patents. These proceedings
could result in substantial cost and diversion of our efforts. Finally, some of
our patent protection in the U.S. is not available to us in foreign countries
due to the laws of those countries.

OUR PRODUCTS COULD INFRINGE ON THE INTELLECTUAL PROPERTY RIGHTS OF OTHERS WHICH
COULD REQUIRE US TO PAY SUBSTANTIAL ROYALTIES.

        There are a significant number of U.S. and foreign patents and patent
applications submitted for technologies in, or related to, our area of business.
As a result, any application or exploitation of our technology could infringe
patents or proprietary rights of others and any licenses that we might need as a
result of such infringement might not be available to us on commercially
reasonable terms, if at all. This may lead others to assert patent infringement
or other intellectual property claims against us. We may have to pay substantial
damages, including treble damages, for past infringement if it is ultimately
determined that our products infringe on another party's intellectual property
rights. We could also be prohibited from selling our products before we obtain a
license, which, if available at all, may require us to pay substantial
royalties. Even if a claim is without merit, defending a lawsuit takes
significant time, may be expensive and may divert management attention from
other business concerns. Any public announcements related to litigation or
interference proceedings initiated or threatened against us could harm our
business and cause our stock price to decline.

WE DEPEND ON ATTRACTING AND RETAINING KEY EMPLOYEES.

        We are highly dependent on the principal members of our management staff
and research and development group, including Collin J. D'Silva, our Chief
Executive Officer and a co-founder, and Douglas T. Gjerde, Ph.D., our Chief
Scientific Officer and a co-founder. We have entered into employment agreements
with Mr. D'Silva and Dr. Gjerde, but not with all of our other key employees.
The loss of services of any of these individuals could seriously harm our
product development and commercialization efforts and could harm our business.

        Our future success will also depend on our ability to attract, hire and
retain additional personnel, including sales and marketing personnel, technical
support and customer service staff and application scientists. There is intense
competition for qualified personnel in our industry, especially for experienced
personnel in the areas of chemistry and molecular biology, software and electric
engineering, manufacturing and marketing, and there can be no assurance that we
will be able to continue to attract and retain such personnel. Failure to
attract and retain key personnel could materially harm our business.

                                       11
<PAGE>
WE WILL NEED TO EFFECTIVELY MANAGE OUR GROWTH IF WE ARE TO SUCCESSFULLY
IMPLEMENT OUR STRATEGY.

        The number of employees and scope of our business operations are
expected to grow as we continue the commercialization of our WAVE System. This
growth may place a strain on our management and operations. Our ability to
manage our growth will depend on the ability of our officers and key employees
to continue to implement and improve our operational, management information and
financial control systems and to expand, train and manage our work force both in
the U.S. and abroad. We may be required to open non-U.S. offices in addition to
our current U.K., Japan and satellite European offices, which could result in
additional burdens on our systems and resources. Our inability to manage our
growth effectively could harm our business.

OUR FAILURE TO COMPLY WITH ANY APPLICABLE GOVERNMENT REGULATIONS OR OTHERWISE
RESPOND TO CLAIMS RELATING TO IMPROPER HANDLING, STORAGE OR DISPOSAL OF
HAZARDOUS CHEMICALS WHICH WE USE MAY ADVERSELY AFFECT OUR RESULTS OF OPERATIONS.

        Our research and development and manufacturing activities involve the
controlled use of hazardous materials and chemicals. We are subject to federal,
state and local laws and regulations governing the use, storage, handling and
disposal of such materials and certain waste products. If we fail to comply with
applicable laws or regulations we could be required to pay penalties or be held
liable for any damages that result and this liability could exceed our financial
resources. We cannot assure you that accidental contamination or injury will not
occur. Any such accident could damage our research and manufacturing facilities
and operations, resulting in delays and increased costs.

                         RISKS RELATED TO THIS OFFERING

WE ARE CONTROLLED BY A SMALL GROUP OF OUR EXISTING STOCKHOLDERS, WHOSE INTERESTS
MAY DIFFER FROM OTHER STOCKHOLDERS.

        Our directors, executive officers and principal stockholders and certain
of their affiliates beneficially own approximately 79% of the outstanding equity
securities, and after the offering will beneficially own approximately 64% of
our outstanding equity securities. Accordingly, they collectively will have a
significant influence in determining the outcome of any corporate transaction or
other matter submitted to the stockholders for approval, including mergers,
acquisitions, consolidations and the sale of all or substantially all of our
assets, and also the power to prevent or cause a change in control. The
interests of these stockholders may differ from the interests of the other
stockholders.

NEW INVESTORS IN OUR COMMON STOCK WILL EXPERIENCE IMMEDIATE AND SUBSTANTIAL
DILUTION.

        The initial public offering price will be substantially higher than the
book value per share of our common stock. Investors purchasing common stock in
this offering will, therefore, incur immediate dilution of $10.12 in pro forma
net tangible book value per share of common stock, based on an assumed public
offering price of $13.00 per share. In addition, investors will incur additional
dilution upon the exercise of outstanding stock options and warrants. See
"Dilution" for a more detailed discussion of the dilution new investors will
incur in this offering.

PROVISIONS IN OUR CHARTER MAY INHIBIT A TAKEOVER, WHICH COULD LIMIT THE PRICE
INVESTORS MIGHT BE WILLING TO PAY IN THE FUTURE FOR OUR COMMON STOCK.

        Provisions in our certificate of incorporation and bylaws may have the
effect of delaying or preventing a change in control or changes in our
management that stockholders consider favorable or beneficial. If a change of
control or change in management is delayed or prevented, the market price of our
common stock could decline.

                                       12
<PAGE>
OUR COMMON STOCK MAY HAVE A VOLATILE PUBLIC TRADING PRICE.

        Prior to this offering, there will have been no public market for our
common stock. An active public market for our common stock may not develop or be
sustained after this offering. We and the underwriters, through negotiations,
will determine the initial public offering price. The initial public offering
price is not necessarily indicative of the market price at which the common
stock will trade after this offering. The market prices for securities of
companies comparable to us have been highly volatile, and the market has
experienced significant price and volume fluctuations that are unrelated to the
operating performance of the individual companies. Many factors have a
significant adverse effect on the market price of the common stock.

WE HAVE NEVER PAID DIVIDENDS ON OUR CAPITAL STOCK AND DO NOT INTEND TO DO SO FOR
  THE FORSEEABLE FUTURE.

        We have never paid dividends on our capital stock and do not intend to
pay any dividends for the foreseeable future. We have agreed not to pay
dividends without the consent of our lenders. See "Dividend Policy."

THE SALE OF A SUBSTANTIAL NUMBER OF OUR COMMON SHARES AFTER THIS OFFERING MAY
  AFFECT OUR SHARE PRICE.

        The market price of our common shares could decline as a result of sales
of substantial amounts of our common stock in the public market after the
closing of this offering or the perception that substantial sales could occur.
These sales also might make it difficult for us to sell equity securities in the
future at a time and at a price that we deem appropriate.

        After this offering, we will have outstanding 20,037,200 shares of
common stock, assuming conversion of our convertible notes and accrued interest
on such notes and the exercise of warrants to acquire 300,000 shares of common
stock that will expire at the closing of this offering. This includes the
4,000,000 shares of common stock that we are selling in this offering and which
may be resold in the public market immediately. A substantial majority of the
remaining outstanding shares will be subject to lock-up agreements and will
become available for sale 180 days after this offering. The remaining shares
will become available for sale at various times following the date of this
offering. See "Shares Eligible for Future Sale" on page 48 for more information
regarding common stock that may be sold in the market after the closing of this
offering.

                           FORWARD-LOOKING STATEMENTS

        We have made forward-looking statements in this prospectus that are
subject to risks and uncertainties. Many of these forward-looking statements
refer to our plans, objectives, expectations and intentions, as well as our
future financial results. You can identify these forward-looking statements by
forward-looking words such as "expects," "anticipates," "intends," "plans,"
"may," "will," "believes," "seeks," "estimates" and similar expressions. Because
these forward-looking statements involve risks and uncertainties, there are
important factors that could cause our actual results to differ materially from
those expressed or implied by these forward-looking statements, including our
plans, objectives, expectations and intentions and other factors discussed under
"Risk Factors" and other factors identified by cautionary language used
elsewhere in this prospectus. Before you invest in our common stock, you should
be aware that the occurrence of the events described in these risk factors and
elsewhere in this prospectus could materially and adversely affect our business,
financial condition and results of operations.

                                       13
<PAGE>
                                USE OF PROCEEDS

        We expect to receive net proceeds of $47.4 million from the sale of
4,000,000 shares of common stock, assuming a public offering price of
$13.00 per share and after deducting underwriting discounts and commissions of
$3.6 million and estimated expenses of $1.0 million. If the underwriters
exercise their over-allotment option in full, we will receive net proceeds of
this offering of approximately $54.6 million.

        We intend to use the net proceeds of this offering for the expansion of
the manufacturing capacity of our San Jose, California manufacturing facility,
continuing product development and technology research, costs related to
building our sales and marketing organization, reduction in our outstanding debt
and other general working capital needs and for general corporate purposes.

        We have not determined the specific amounts we plan to spend on any of
the areas listed above or the timing of these expenditures. Our management will
have broad discretion in allocating and utilizing the net proceeds from this
offering. The amounts and timing of our actual expenditures will depend on many
factors, including the status of our product development and commercialization
efforts, the amount of proceeds actually raised in this offering, the amount of
cash generated by our operations, the efforts of our competitors, and marketing
and sales activities. We may also use a portion of the proceeds for the
acquisition of, or investment in, companies, technologies or assets that
complement our business. However, we have no present understandings, commitments
or agreements to enter into any potential acquisitions and investments. Pending
application of the net proceeds as described above, we intend to invest the net
proceeds of the offering in short-term, investment-grade, interest-bearing
securities.

                                DIVIDEND POLICY

        We have never declared or paid any cash dividends on our capital stock
and we do not anticipate paying any cash dividends on our common stock in the
foreseeable future. We currently expect to retain all earnings, if any, for
investment in our business. In addition, the terms of our current credit
facilities prohibit us from paying cash dividends without our lenders' consent.

        Dividends on our common stock will be paid only if and when declared by
our board of directors. The board's ability to declare a dividend is subject to
limits imposed by Delaware corporate law. In determining whether to declare
dividends, the board may consider our financial condition, results of
operations, working capital requirements, future prospects and other relevant
factors.

                                       14
<PAGE>
                                 CAPITALIZATION

        The following table describes our capitalization as of December 31,
1999:

        - on an actual basis;

        - on a pro forma basis, giving effect to the sale of the assets related
          to our non-life sciences instrument product line, the assumed
          conversion at $5.00 per share of $12.0 million aggregate principal
          amount of our convertible notes plus accrued interest into 2,712,200
          shares of common stock, the issuance of 300,000 shares of common stock
          at $5.00 per share upon the exercise of warrants that will expire at
          the closing of this offering and the sale of 25,000 shares of common
          stock at $10.00 per share in March 2000; and

        - on a pro forma as adjusted basis reflecting the sale of the common
          stock offered by us at an assumed initial public offering price of
          $13.00 per share after deducting the underwriting discounts and
          commissions and estimated offering expenses.

        You should read this table together with the consolidated financial
statements and the related notes and our unaudited pro forma financial
information and the related notes appearing at the end of this prospectus and
the information under "Management's Discussion and Analysis of Financial
Condition and Results of Operations" and "Use of Proceeds."

<TABLE>
<CAPTION>
                                                                   AS OF DECEMBER 31, 1999
                                                              ----------------------------------
                                                                                      PRO FORMA
                                                               ACTUAL    PRO FORMA   AS ADJUSTED
                                                              --------   ---------   -----------
                                                                        (IN THOUSANDS)
<S>                                                           <C>        <C>         <C>
Long-term obligations, less current portion.................  $    117   $    117      $    117
Convertible notes payable...................................    12,421         --            --
Stockholders' equity:
Preferred stock, $0.01 par value; 15,000,000 shares
  authorized,
  no shares issued and outstanding..........................        --         --            --
Common stock, $0.01 par value; 30,000,000 shares authorized,
  13,000,000 shares issued and outstanding, actual;
  16,037,200 shares issued and outstanding pro forma; and
  20,037,200 shares issued
  and outstanding pro forma as adjusted(1)..................       130        160           200
Additional paid-in capital..................................    10,232     24,372        71,692
Other capital items.........................................      (117)      (117)         (117)
Accumulated deficit.........................................   (12,344)   (12,030)      (12,030)
                                                              --------   --------      --------
  Total stockholders' equity (deficit)......................    (2,099)    12,385        59,745
                                                              --------   --------      --------
  Total capitalization......................................  $ 10,439   $ 12,502      $ 59,862
                                                              ========   ========      ========
</TABLE>

- ------------------------

(1)   The number of outstanding shares (actual, pro forma and pro forma, as
     adjusted) does not include the following:

        - 152,450 shares that we could issue upon exercise of outstanding
          warrants with an exercise price of $5.00 per share;

        - 6,000,000 shares that we could issue under our employee stock option
          plan. As of the date of this prospectus, we have issued options to
          purchase 3,724,250 shares of common stock at an exercise price ranging
          from $5.00 to $10.00 per share, except that options relating to 15,000
          shares issued to one of our non-employee directors may be exercised at
          a price equal to the lower of $5.00 or 50% of the public offering
          price for this offering. We may issue options to acquire up to
          2,275,750 additional shares of our common stock under this plan; and

                                       15
<PAGE>
        - an underdetermined number of additional shares we are obligated to
          issue to existing stockholders if the public offering price for this
          offering is less than $10.00 per share. The number of additional
          shares we will have to issue will depend on the offering price. In
          addition, we will have to adjust the number of shares we will have to
          issue upon exercise of the warrants and conversion of the notes
          described above if the public offering price for this offering is less
          than $10.00 per share.

                                       16
<PAGE>
                                    DILUTION

        Our pro forma net tangible book value as of December 31, 1999,
reflecting the sale of the assets related to our non-life sciences instrument
product line, the assumed conversion at $5.00 per share of our convertible notes
and accrued interest into 2,712,200 shares of common stock, the issuance of
300,000 shares of common stock at $5.00 per share upon the exercise of warrants
that will expire prior to the closing of this offering and the sale of 25,000
shares of common stock at $10.00 per share in March 2000 was approximately
$10.4 million, or approximately $0.65 per share. We have calculated this amount
by:

        - subtracting our pro forma total liabilities from our pro forma total
          tangible assets; and

        - then dividing the difference by the total pro forma number of shares
          of common stock outstanding.

        If we give effect to our receipt of the net proceeds from our sale of
4,000,000 shares of common stock at an assumed public offering price of $13.00
per share, after deducting estimated underwriting discounts and estimated
offering expenses, our pro forma as adjusted net tangible book value at
December 31, 1999 would have been approximately $57.8 million, or $2.88 per
share. This represents an immediate increase in pro forma net tangible book
value of $2.23 per share to existing stockholders and an immediate dilution of
$10.12 per share to new investors. The following table illustrates this dilution
on a per share basis:

<TABLE>
<S>                                                           <C>        <C>
Assumed initial public offering price per share.............              $13.00
  Actual net tangible book value per share as of December
    31, 1999, before this offering and pro forma
    adjustments.............................................   $(0.47)
  Increase per share attributable to sale of assets related
    to our non-life sciences instrument product line........     0.18
  Increase per share attributable to the assumed conversion
    of convertible notes and accrued interest, exercise of
    warrants and issuance of 25,000 shares of common
    stock...................................................     0.94
                                                               ------
  Pro forma net tangible book value per share as of December
    31, 1999................................................     0.65
  Pro forma as adjusted increase in net tangible book value
    attributable to this offering...........................     2.23
                                                               ------
Pro forma as adjusted net tangible book value per share
  after this offering.......................................                2.88
                                                                          ------
Dilution per share to new investors.........................              $10.12
                                                                          ======
</TABLE>

        The following table summarizes, on a pro forma as adjusted basis, as of
December 31, 1999, the total number of shares of common stock purchased from us,
the total consideration paid and the average price per share paid by existing
stockholders and to be paid by the new investors in this offering at an assumed
initial public offering price of $13.00 per share, before deducting estimated
underwriting discounts and offering expenses.

<TABLE>
<CAPTION>
                                           SHARES PURCHASED          TOTAL CONSIDERATION
                                      ---------------------------   ----------------------   AVERAGE PRICE
                                      PRO FORMA NUMBER   PERCENT      AMOUNT      PERCENT      PER SHARE
                                      ----------------   --------   -----------   --------   -------------
<S>                                   <C>                <C>        <C>           <C>        <C>
Existing stockholders...............     $16,037,200       80.0%    $24,532,605     32.1%        $1.53
New investors.......................       4,000,000       20.0      52,000,000     67.9         13.00
                                         -----------      -----     -----------    -----
    Total...........................     $20,037,200      100.0%    $76,532,605    100.0%
                                         ===========      =====     ===========    =====
</TABLE>

        If all outstanding options and warrants having an exercise price less
than the offering price had been exercised as of December 31, 1999, the dilutive
effect to new investors would decrease to $9.79 per share. See "Capitalization,"
"Management--Stock Option and Other Compensation Plans" and "Description of
Capital Stock."

                                       17
<PAGE>
        If the underwriters exercise their over-allotment option in full:

        - the number of shares of common stock held by existing stockholders
          will decrease to approximately 77.7% of the total number of shares of
          our common stock outstanding; and

        - the number of shares held by new investors will increase to 4,600,000
          shares, or approximately 22.3% of the total number of our common stock
          outstanding.

                                       18
<PAGE>
                            SELECTED FINANCIAL DATA

        The statement of operations data for the years ended December 31, 1997,
1998 and 1999 and the balance sheet data as of December 31, 1998 and 1999 are
derived from our historical consolidated financial statements and notes thereto
included elsewhere in this prospectus, which have been audited by Deloitte &
Touche LLP, independent auditors. The statement of operations data for the years
ended December 31, 1995 and 1996 and the balance sheet data as of December 31,
1995, 1996 and 1997 are derived from our audited historical consolidated
financial statements which are not included in this prospectus.

        The following selected financial data should be read in conjunction with
our consolidated financial statements and the related notes thereto appearing
elsewhere in this prospectus and the information under "Management's Discussion
and Analysis of Financial Condition and Results of Operations."

<TABLE>
<CAPTION>
                                                                 YEAR ENDED DECEMBER 31,
                                                   ----------------------------------------------------
                                                   1995(1)    1996(1)      1997       1998       1999
                                                   --------   --------   --------   --------   --------
                                                          (IN THOUSANDS, EXCEPT PER SHARE DATA)
<S>                                                <C>        <C>        <C>        <C>        <C>
STATEMENT OF OPERATIONS DATA:
Net sales........................................   $7,933    $12,535    $11,577    $18,935    $23,035
Cost of good sold................................    3,516      6,760      6,336      9,590     12,090
                                                    ------    -------    -------    -------    -------
Gross profit.....................................    4,417      5,775      5,241      9,345     10,945
Selling, general and administrative expenses.....    2,042      4,751      6,412      8,160     11,532
Research and development expenses................    1,518      1,385      2,047      3,159      6,297
                                                    ------    -------    -------    -------    -------
Operating expenses...............................    3,560      6,136      8,459     11,319     17,829
Income (loss) before income taxes................      728       (644)    (3,646)    (2,506)    (8,082)
Net income (loss)................................   $  494    $  (415)   $(2,410)   $(1,576)   $(9,827)
                                                    ======    =======    =======    =======    =======
Basic and diluted net income (loss) per share....   $ 0.05    $ (0.04)   $ (0.22)   $ (0.13)   $ (0.76)
                                                    ======    =======    =======    =======    =======
Basic and diluted weighted average shares
  outstanding(2).................................   10,000     11,000     11,145     12,279     13,000
                                                    ======    =======    =======    =======    =======
</TABLE>

<TABLE>
<CAPTION>
                                                                    AS OF DECEMBER 31,
                                                   ----------------------------------------------------
                                                   1995(1)    1996(1)      1997       1998       1999
                                                   --------   --------   --------   --------   --------
                                                                      (IN THOUSANDS)
<S>                                                <C>        <C>        <C>        <C>        <C>
BALANCE SHEET DATA:
Working capital (deficit)........................   $1,272    $   324    $(1,669)   $ 1,845    $ 3,494
Total assets.....................................    5,774      9,527     10,010     14,736     19,964
Long-term debt, less current portion.............      626      1,597      1,128        695     12,538
Total stockholders' equity (deficit).............    2,429      2,114        991      6,649     (2,099)
</TABLE>

- ------------------------

(1)  Financial information prior to July 1, 1997 is that of our predecessor
     corporation, CETAC Holding Company, Inc. and its subsidiaries.

(2)  See Note A of notes to our consolidated financial statements for an
     explanation of the determination of the number of shares used in computing
    per share data.

                                       19
<PAGE>
                      MANAGEMENT'S DISCUSSION AND ANALYSIS
                OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

        THE FOLLOWING DISCUSSION SHOULD BE READ IN CONJUNCTION WITH OUR
CONSOLIDATED FINANCIAL STATEMENTS AND NOTES INCLUDED ELSEWHERE IN THIS
PROSPECTUS.

OVERVIEW

        We provide innovative research tools to the life sciences industry.
These tools enable researchers to discover and understand variations in the
human genetic code, or genome, in order to accelerate and improve drug
development and diagnostics. We generate revenues from the sale of our WAVE
System and associated consumable products and reagents. Through March 1, 2000,
we have sold over 240 WAVE Systems to major academic research centers and
commercial biopharmaceutical companies in 20 countries. During 1999, revenues
from the sale of consumable products represented approximately 19% of our net
sales derived from our life sciences business. We expect that over the next five
years, sales from consumable products will increase as a percentage of our net
sales.

        The following graph displays sales of WAVE System units during each
calendar quarter from July 1, 1997 through December 31, 1999:

EDGAR REPRESENTATION OF DATA POINTS USED IN PRINTED GRAPHIC

<TABLE>
<CAPTION>
UNITS SOLD
<S>         <C>   <C>   <C>   <C>   <C>   <C>   <C>   <C>   <C>   <C>
Date
            Q397  Q497  Q198  Q298  Q398  Q498  Q199  Q299  Q399  Q499
               3     2     4    17    21    30    24    32    38    39
</TABLE>

        Before July 1, 1997, we produced and sold a number of non-life sciences
instruments and consumable products through CETAC Holding Company, Inc. and its
subsidiaries. On July 1, 1997, we merged these companies into a new Delaware
corporation known as Transgenomic, Inc. for the purpose of pursuing our new life
sciences business, but continue to produce our non-life sciences product lines.
Financial information for periods ending before July 1, 1997 is that of CETAC
Holding Company, Inc. and its subsidiaries. Net sales from our non-life sciences
instrument and consumables product lines were $9.4 million, $11.6 million, and
$9.1 million, respectively, for the years ended 1997, 1998 and 1999,
representing approximately 81%, 61% and 39% of our net sales, respectively, for
these periods. We have decided to divest ourselves of our non-life sciences
product lines. Accordingly, we recently signed a letter of intent to sell the
assets related to our non-life sciences instrument product line.

        Since our decision to focus on our life sciences business, we have
incurred significant losses, and as of December 31, 1999, we had an accumulated
deficit of $12.3 million. Our losses have resulted principally from costs
incurred in research and development, marketing and sales, and from general and
administrative costs associated with our operations. We expect to continue to
incur substantial research and development, marketing and sales, and general and
administrative costs. As a result, we will need to generate significantly higher
revenue to achieve profitability.

                                       20
<PAGE>
        Our operating results may fluctuate significantly depending upon many
factors. These include the market acceptance of our products, the success and
timing of sales of our WAVE System, the introduction of new products by our
competitors, the timing of commercial availability of new applications for our
technology, and the timing and extent of our research and development efforts.
Our limited operating history in the life sciences industry makes accurate
prediction of future operations difficult. If our operating results fail to meet
the expectations of securities analysts or investors, it could cause our stock
price to decline. See "Risk Factors."

RESULTS OF OPERATIONS

YEARS ENDED DECEMBER 31, 1999 AND 1998

        NET SALES.  Net sales increased 22%, from $18.9 million for the year
ended 1998 to $23.0 million for the year ended 1999. Sales from our life
sciences business increased 91%, from $7.3 million in 1998 to $13.9 in 1999.
This increase was primarily related to an increase in WAVE Systems sold. Total
revenues from sales of WAVE Systems increased 107%, from $5.4 million in 1998 to
$11.2 million in 1999. Life science consumables sales increased 42%, from
$1.9 million in 1998 to $2.7 million in 1999. This increase was due primarily to
a larger installed base of WAVE Systems. In addition, we acquired another
manufacturer of life science reagents during the year and began including sales
of these products in our revenues. Sales of our non-life sciences instruments
and related consumables decreased 22%, from $11.6 million in 1998 to
$9.1 million in 1999. This decrease was primarily related to an industry wide
consolidation and a reorganization of our dealer and distributor network.

        COST OF GOODS SOLD.  Cost of goods increased 26% from $9.6 million in
1998 to $12.1 million in 1999, representing 51% of net sales in 1998, as
compared to 52% in 1999.

        SELLING, GENERAL AND ADMINISTRATIVE EXPENSES.  Selling, general and
administrative expenses increased 41%, from $8.2 million in 1998 to
$11.5 million in 1999. The increase was primarily the result of building an
initial direct sales and marketing staff in the United States for our entry into
the life sciences market. We also expanded our life sciences sales and support
efforts in Europe, along with the opening of our marketing and technical support
office in Japan. We paid a one-time advisory services fee of $550,000 in 1999 in
connection with consulting and financial advisory services. We expect selling,
general and administrative expenses to continue to increase over the next
several years to support our growing business activities and to continue
expansion of our sales and marketing efforts, and due to the costs associated
with operating a public company.

        RESEARCH AND DEVELOPMENT EXPENSES.  Research and development expenses
increased 97%, from $3.2 million in 1998 to $6.3 million in 1999. These expenses
represented 17% of net sales in 1998 versus 27% of net sales in 1999. Research
and development expenses consisted primarily of salaries and related personnel
costs of researchers and software developers, material costs for prototypes and
test units, legal expenses from intellectual property research activities, and
testing and enhancement of our products, primarily the WAVE System. We expense
our research and development costs in the year in which they are incurred. The
increase from 1998 to 1999 in these expenses was primarily attributable to an
increase in our life science research, which was approximately 70% of total
research and development costs in 1999. We expect research and development
spending to increase significantly over the next several years as we expand our
research and product development efforts.

        OTHER EXPENSES.  Other expenses, which consisted mainly of net interest
expense, increased 126%, from $532,000 in 1998 to $1.2 million in 1999. This
increase was primarily related to our placement of $12.0 million of convertible
notes in March 1999. We also made interest payments under our bank loan
agreements.

        INCOME TAXES.  The income tax benefit in 1998 was $0.9 million, while in
1999 income tax expense was $1.7 million. A valuation reserve of $4.5 million
was recorded in 1999 due to our cumulative losses in recent years and an
inability to utilize any additional losses as carrybacks. As of December 31,

                                       21
<PAGE>
1999, we had federal net operating loss carryforwards of approximately
$11.6 million. We also had federal research and development tax credit
carryforwards of approximately $131,000. The net operating loss and credit
carryforwards will expire at various dates from 2012 through 2019, if not
utilized. We also had state income tax loss carryforwards of $2.9 million. These
carryforwards will also expire at various dates if not utilized.

        As of December 31, 1998 and 1999, we had deferred tax assets of
approximately $2.0 million and $4.7 million, respectively. The net deferred tax
asset at December 31, 1999 has been offset by a valuation allowance of
$4.5 million due to our cumulative losses in recent years and an inability to
utilize any additional losses as carrybacks. The net deferred tax assets were
$2.0 million and $180,000 as of December 31, 1998 and 1999, respectively.
Deferred tax assets relate primarily to net operating loss carryforwards.

YEARS ENDED DECEMBER 31, 1998 AND 1997

        NET SALES.  Net sales increased 64%, from $11.6 million in 1997 to
$18.9 million in 1998. Of the $7.3 million increase, $5.1 million was due to
increased sales of our WAVE System and related consumable products. Sales of
life sciences consumable products were $1.9 million in each of 1997 and 1998.
Sales of non-life sciences products increased 22%, from $9.4 million in 1997 to
$11.5 million in 1998. This increase was primarily due to the release of an
upgraded laser-based solid sampling product in the first quarter of 1998.

        COST OF GOODS SOLD.  Cost of goods sold increased 52%, from
$6.3 million in 1997 to $9.6 million in 1998, but decreased from 55% of net
sales in 1997 to 51% of net sales in 1998. This decrease was the result of
higher material costs for the WAVE System being offset by minimal in-house
production costs, and the relatively fixed nature of the expenses related to our
non-life sciences instrument product line being allocated over a larger revenue
base.

        SELLING, GENERAL AND ADMINISTRATIVE EXPENSES.  Selling, general and
administrative expenses increased 27%, from $6.4 million in 1997 to
$8.2 million in 1998. The increase was primarily related to increases in sales
and marketing expenses for the commercialization of our WAVE System.
Administrative staff also grew to support our growing business activities
resulting in higher salary and employee benefit costs.

        RESEARCH AND DEVELOPMENT EXPENSES.  Research and development expenses
increased 54%, from $2.0 million in 1997 to $3.2 million in 1998. The increase
was primarily related to compensation for additional personnel engaged in the
development of the WAVE System.

        OTHER EXPENSES.  Other expenses, which consisted mainly of net interest
expense, increased 25%, from $427,000 in 1997 to $532,000 in 1998. This increase
was primarily due to the payment of interest on $1.5 million of mezzanine
short-term financing obtained at the end of 1997. This short-term financing was
repaid in 1998. We also made interest payments under our bank loan agreements.

        INCOME TAXES.  The income tax benefit for 1997 was $1.2 million, while
the benefit for 1998 was $0.9 million. The effective tax rate for 1997 was 34%,
and the effective tax rate for 1998 was 37%. As of December 31, 1998, we had
federal net operating loss carryforwards of approximately $3.9 million. We also
had federal research and development tax credit carryforwards of approximately
$76,000. The net operating loss and credit carryforwards will expire at various
dates from 2012 through 2018, if not utilized. We also had state income tax loss
carryforwards of $1.4 million. These carryforwards will also expire at various
dates if not utilized.

LIQUIDITY AND CAPITAL RESOURCES

        We have experienced net losses and negative cash flows from operations
during the past three years. As a result, we had an accumulated deficit of
$12.3 million as of December 31, 1999. We have financed our operations primarily
through the private placements of common stock, the issuance of

                                       22
<PAGE>
convertible notes and, to a lesser extent, through bank financings and a
revolving credit facility. As of December 31, 1999, we had received net proceeds
of $10.4 million from issuance of common stock, and $11.4 million from the
issuance of convertible notes. We also sold 25,000 shares of common stock to one
of our directors at $10.00 per share in March 2000 for proceeds of $250,000. In
addition, we anticipate the exercise of warrants to purchase 300,000 shares of
common stock at or before the closing of this offering which will provide an
additional $1.5 million in cash. As of December 31, 1999, we had approximately
$150,000 in cash and cash equivalents.

        We have a long sales cycle due to the need to educate potential
customers prior to the purchase of the WAVE System and to communicate the
benefits of our products to a variety of constituencies within potential
customer groups. We may need to expend substantial funds and sales effort with
no assurance that a sale will result. The need to penetrate new markets often
entails extension of our terms of sale. As a result, we may experience
collection periods of up to a year or more in connection with sales of our WAVE
System.

        In March 2000, we signed a letter of intent to sell the assets related
to our non-life sciences instrument product line for $6,000,000. Of the total
purchase price, $5,000,000 will be paid in cash at the closing of the asset sale
and $1,000,000 will be paid with a one-year promissory note bearing interest at
a market rate. The sale is expected to provide that we will retain all accounts
receivable outstanding as of the date of the sale. Our accounts receivable from
the product line were approximately $1.5 million at December 31, 1999. After the
sale, we may experience difficulty in collecting the remaining accounts
receivable due to the lack of a continuing relationship with customers.

        Our operating activities resulted in net outflows of $2.6 million in
1997, $3.4 million in 1998 and $8.7 million in 1999. The operating cash outflows
for these periods resulted from significant investments in research and
development, sales, marketing and services, which resulted in operating losses.

        Net cash used in investing activities was $470,000 for the year ended
December 31, 1997, compared to net cash used in investing activities of
$1.5 million in 1998 and $3.5 million in 1999. The increase was primarily due to
the increase in purchases of property and equipment and the purchase of
technology rights related to our non-life sciences product lines.

        Net cash provided by financing activities was $3.2 million for the year
ended December 31, 1997, compared to net cash provided of $4.6 million and
$12.2 million in 1998 and 1999, respectively. The increase was primarily due to
the issuance of convertible notes which netted $11.4 million, compared to the
net proceeds of $7.3 million received in 1998 on the sale of common stock. We
reduced notes payable by $2.7 million in 1998. In 1997 we received $1.7 million
net proceeds from the sale of stock. We also increased notes payable in 1997 by
a net $1.9 million.

        At December 31, 1998 and 1999, we had outstanding borrowings under our
revolving credit facility with First National Bank of Omaha in the amounts of
approximately $3.2 million and $4.3 million, respectively. Borrowings under our
revolving credit facility are limited to the lesser of $5.0 million or a
borrowing base calculated from our accounts receivable and inventories. The
facility bears interest based on the prime lending rate and interest is payable
monthly. The interest rate at December 31, 1998 and 1999 was 7.75% and 8.50%,
respectively. This facility expires July 31, 2000, but we anticipate that it
will be extended. Substantially all of our assets and life insurance policies
for our executive officers are pledged as collateral to secure borrowings under
this facility. The loan agreement relating to this facility contains a number of
restrictive covenants, including a prohibition on the payment of dividends, the
repurchase of our stock, and the redemption of stock options and warrants, among
other things, without the written agreement of the lender. As of December 31,
1999, the Company was not in compliance with all of these covenants. However, a
waiver was obtained from the bank as of December 31, 1999.

        Our capital expenditures budget for 2000 is approximately $2.0 million.
Capital expenditures for the current year are expected to relate to facility and
equipment improvements related to our life sciences business.

                                       23
<PAGE>
        Our capital requirements depend on a number of factors, including the
level of our research and development activities, market acceptance of our
products, the resources we devote to developing and supporting our products, and
other factors. We expect to devote substantial capital resources to continue our
research and development efforts, to expand our marketing and sales and customer
support activities, and for other general corporate activities.

        We believe that our current cash balances, together with the proceeds
from this offering, from our existing credit lines and from the sale of stock
upon the exercise of outstanding warrants and from cash provided from operations
will be sufficient to fund our operations for the foreseeable future. During or
after this period, if cash generated by operations is insufficient to satisfy
our liquidity requirements, we may need to sell additional equity or debt
securities, or obtain additional credit arrangements. The sale of additional
equity or convertible debt securities may result in additional dilution to our
stockholders. We cannot assure you that any financing arrangement will be
available in amounts or on terms acceptable to us.

IMPACT OF INFLATION

        We do not believe that price inflation had a material adverse effect on
our financial condition or results of operations during the periods presented.

RECENT ACCOUNTING PRONOUNCEMENTS

        In June 1998, the Financial Accounting Standards Board issued Statement
of Financial Accounting Standards No. 133, "ACCOUNTING FOR DERIVATIVE FINANCIAL
INSTRUMENTS AND FOR HEDGING ACTIVITIES" (SFAS No. 133). This statement, which is
effective for fiscal years beginning after June 15, 2000, requires the
recognition of all derivative financial instruments as either assets or
liabilities in the statement of financial position and measurement of those
instruments at fair value. Management is in the process of determining the
effect, if any, SFAS No. 133 will have on our financial statements.

        In 1999, we adopted Statement of Position 98-1, "Accounting for the
Costs of Computer Software Developed or Obtained for Internal Use" (SOP 98-1)
which, on a prospective basis, revised the accounting for software development
costs. SOP 98-1 requires capitalization of certain costs related to internal use
software once certain criteria have been met. The adoption of this statement did
not have a material impact on our financial statements.

QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

        The primary objective of our investment activities is to preserve
principal while at the same time maximizing the income we receive from our
investments without significantly increasing risk. Some of the securities that
we invest in may have market risk. This means that a change in prevailing
interest rates may cause the principal amount of the investment to fluctuate.
For example, if we hold a security that was issued with a fixed interest rate at
the then-prevailing rate and the prevailing interest rate later rises, the
principal amount of our investment will probably decline. To minimize this risk
in the future, we intend to maintain our portfolio of cash equivalents and
short-term investments in a variety of securities, including commercial paper,
money market funds, government and non-government debt securities. The average
duration of all of our investments in 1999 was less than one year. Due to the
short term nature of these investments, we believe we have no material exposure
to interest rate risk arising from our investments. Therefore, no quantitative
tabular disclosure is presented.

FOREIGN CURRENCY RATE FLUCTUATIONS

        Approximately 50% of our net sales have been to customers in the United
States. While we do sell products in many foreign countries, most of these sales
are made in U.S. dollars. Therefore, we do not have a material exposure to
foreign currency rate fluctuations.

                                       24
<PAGE>
                                    BUSINESS

OVERVIEW

        We provide innovative research tools to the life sciences industry.
These tools enable researchers to discover and understand variations in the
human genetic code, or genome, in order to accelerate and improve drug
development and diagnostics. We believe our WAVE System, which incorporates our
proprietary DNASep separation column and associated software, consumables and
reagents, will become a leading tool to analyze genetic mutations. The WAVE
System allows researchers to analyze both known and unknown genetic mutations
faster, with more accuracy and at a lower cost than other commercially available
techniques. As of March 1, 2000, we had sold over 240 WAVE Systems in 20
countries to major academic research centers and biopharmaceutical companies. In
1999, sales of our WAVE Systems and related consumables accounted for
approximately $14 million in revenues.

        Our WAVE System is designed to perform high-speed, automated analyses of
DNA molecules to identify the type, location and frequency of DNA mutations,
with a high degree of accuracy and consistency. The WAVE System is based on our
proprietary micro-bead technology. Our patented micro-beads are packed into our
proprietary DNASep separation column, which is the key component of our WAVE
System. Each micro-bead has specific surface chemistry that interacts with DNA
molecules. The DNA molecules are then selectively separated from the micro-beads
with a mixture of our liquid reagents. This process is automated by our
proprietary WAVEMaker Software for analysis and interpretation.

INDUSTRY BACKGROUND

DNA AND GENOMICS-BASED RESEARCH

        The human body is composed of billions of cells each containing
deoxyribonucleic acid, or DNA, which encodes the basic instructions for cellular
function. This complete set of an individual's DNA is called the genome, or
genetic code, and is composed of 23 pairs of chromosomes, which are further
divided into over 100,000 smaller regions called genes. Each gene is comprised
of four nucleotide bases, known as G, C, A and T and the order of these bases is
called the DNA sequence. Genes are used as the templates for the production of
proteins and it is the proteins that direct cell function and ultimately the
development of individual traits. Any variation in any part of a gene, called a
mutation or polymorphism, may result in a change in cell function often leading
to disease.

        Genomics is the systematic and comprehensive analysis of the sequence,
structure and function of the genes which comprise the genome with the objective
of identifying and understanding the role of genes in human physiology and
disease. Within a very short period, due to public efforts such as the Human
Genome Project and the efforts of various private companies, the human genome
will be completely sequenced. The efforts of the Human Genome Project have
centered on determining the DNA sequence of a limited number of individuals.
Genomics researchers are now attempting to understand variations in this DNA
sequence information and how it correlates to disease in order to develop new
drugs, treatments and diagnostic methods.

IMPORTANCE OF THE DISCOVERY OF GENETIC VARIATION

        There are a variety of mutations known to occur in DNA sequences. The
most common form of genetic mutation involves a change in a single nucleotide
base and is called a single nucleotide polymorphism, or SNP. Other types of
genetic mutation include the insertion or deletion of several nucleotide bases
and translocation or repetition of nucleotide bases. The identification and
understanding of these mutations, including SNPs, are important because they may
indicate predisposition to a variety of diseases. Since even a single mutation
of a nucleotide base can have a major role in human disease, efforts to
understand and analyze genetic mutations have recently intensified.

        After SNPs or other mutations are discovered, their potential relevance
to disease must be validated by determining the frequency of mutation in
different segments of the population. Some diseases, such as muscular dystrophy,
are caused by DNA mutations in a single gene. Many common diseases, such as
diabetes, cancer and obesity, are caused by mutations in more than one gene.
Since a single mutation or

                                       25
<PAGE>
multiple mutations may be required for a particular disease or trait to manifest
itself, it is necessary to measure a sizable population of these mutations in
order to be able to predict with confidence the association of a mutation with a
particular disease or trait.

        As the Human Genome Project nears completion, the amount of sequenced
DNA available for genetic variation discovery has increased dramatically. New
genetic variations will be an ongoing need as different populations or groups of
individuals are studied. Insertions and deletions are particularly difficult to
efficiently detect with current technologies. In addition, diagnostic
applications require the analysis of DNA samples for both known and unknown
mutations. The increased need for the efficient discovery of genetic mutations,
including SNPs, creates a market opportunity for our WAVE System, as the
discovery of SNPs and other mutations, together with validated medical relevance
may lead to the development of new drugs, treatments and diagnostic products. In
order to do this, researchers will need technologies that provide higher sample
throughput, greater accuracy and reliability, and lower costs than current
methods.

CURRENT METHODS FOR MUTATION ANALYSIS

        Current widely-used DNA mutation analysis technologies were originally
developed primarily for collecting DNA sequencing information and not for the
discovery of mutation and other genetic variations. As these methods have been
modified for use in SNP and other mutation analysis, several limitations have
become clear. Current methods of analysis include the following:

       - GEL ELECTROPHORESIS. Gel electrophoresis is primarily a manual
         separation technique for DNA which uses an electrical current to cause
         DNA fragments to migrate over a gel. Because different lengths of DNA
         will migrate at different speeds, they will be separated by this
         process. The gel is transferred to a fluorescence-imaging camera and
         photographed or scanned into a computer so that the DNA can be
         visualized. If a particular fragment of DNA is required, then it must
         be cut from the gel with a scalpel, the section can be melted to a
         liquid or the DNA can be drawn out of the gel and into the surrounding
         electrolyte with a further application of an electric field. Gel
         electrophoresis provides good separation resolution and the cost of
         associated equipment is relatively inexpensive.

       - CAPILLARY ELECTROPHORESIS. Capillary electrophoresis may be in the form
         of long thin capillaries or embodied in a chip. This technology
         separates DNA by passing an electric current through a capillary tube
         filled with a linear polymer and an electrolyte. DNA is introduced into
         the top of the capillary and the current is applied. This method is
         generally faster than conventional gel electrophoresis and allows for
         simultaneous detection of results.

       - CHIP ARRAY. Chip Array technology uses short fragments of single-strand
         DNA that are attached to small squares on the surface of a "chip" so
         that strands within a square have the same DNA sequence, but this
         sequence is different in each separate square. The sample strand of DNA
         is introduced to this chip and binds, or hybridizes, specifically only
         where it matches the sequence attached to one of the squares. In this
         way a match can be found, if it exists, from a very large array of
         candidate DNA sequences. The chip primarily identifies sequences which
         are known prior to analysis.

       - MASS SPECTROMETRY. Mass spectrometry is a technique that applies a
         charge to the sample and introduces the ionized sample into a chamber
         that measures the mass per charge of each type of molecule. The mass of
         the sample and various fragments produced indicate the identity of the
         molecule that was introduced into the instrument. Although the sequence
         of the DNA is not measured when using mass spectrometry, the
         nucleotides making up the molecule bases can be measured.

LIMITATIONS OF CURRENT METHODS

        Although these techniques are well accepted and established, none of
these methods is ideally suited to the analysis of sequence mutations. The
limitations of current methods include the following:

       - GEL ELECTROPHORESIS. Gel electrophoresis is a time-consuming, labor
         intensive process. Sample introduction, pouring of gels, separation,
         identification of bands, and recovery of DNA must all

                                       26
<PAGE>
         be done manually. In addition, there is no real-time monitoring of the
         process. For example, if an insufficient sample were used for the
         analysis, a researcher would only become aware after several hours of
         experimentation.

       - CAPILLARY ELECTROPHORESIS. Capillary electrophoresis can automate the
         gel electrophoresis process. However, control of the conditions needed
         to determine genetic variation is difficult and the quantities of DNA
         separated are small. It is difficult to collect DNA material for
         further analysis. Another limitation of this technique is the need for
         special columns and chemistries to run each different type of sample.

       - MASS SPECTROMETRY. Mass spectrometry is only a detection method and
         does not incorporate any separation capability, which is essential for
         multiple analyses of DNA molecules, as well as for purification. In
         addition, this method cannot analyze large DNA fragments or double-
         stranded DNA due to its inflexibility and fundamental limitations.

        Gel electrophoresis, capillary electrophoresis, chip-based technologies
and mass spectrometry and certain other technologies only measure known SNPs or
mutations. Sequencing can measure unknown SNPs, but it is expensive and labor
intensive. Insertions, deletions, translocations, and repetitions and other
mutations are very difficult to measure using any of these technologies. All of
these basic technologies, when applied to scanning for unknown mutations have
significant disadvantages related to accuracy of results and the cost and time
needed to obtain the results. These disadvantages limit the usefulness of these
techniques for the efficient discovery of genetic variation.

THE TRANSGENOMIC SOLUTION

        We believe our WAVE System, which incorporates our proprietary DNASep
technology and associated software, consumables and reagents, will become a
leading tool to analyze genetic variation. The WAVE System allows researchers to
analyze both known and unknown genetic mutations faster, with more accuracy and
at a lower cost than other commercially available techniques. We believe key
benefits of the WAVE System include the following:

       - HIGH SPEED. DNA separation and analysis using our WAVE System can be
         performed up to 10 times faster than current methods, depending on the
         application. Separation times using our DNASep columns average
         approximately 5-7 minutes per sample and can be as short as 3 minutes,
         depending on the application. After the separation, results are
         immediately available for quantification, analysis, reporting and
         archiving.

       - IMPROVED DATA ACCURACY. Our WAVE System produces more accurate and
         consistent data than other existing techniques for mutation analysis.
         Accuracy in discovery of known and unknown mutations is greater than
         95% with the WAVE System. The higher level of data quality achievable
         with the WAVE System is extremely valuable to the life sciences
         researcher.

       - REDUCED COST. Because our WAVE System is completely automated, the
         amount of time per sample spent by a researcher is greatly reduced. The
         WAVE System analyzes very small DNA samples and does not require
         additional sample purification. This allows samples to be analyzed with
         a smaller volume of chemical reagents than other methods. In addition,
         the WAVE System can detect DNA mutations directly without the use of
         expensive fluorescent tags or markers required by other techniques.
         Savings in labor, reagents and tags significantly reduce the costs per
         analysis over current methods.

       - AUTOMATION AND EASE OF USE. The WAVE System is fully automated and easy
         to operate. A multiple number of amplified DNA samples can be loaded
         into the WAVE System's autosampler. Once loaded, the appropriate
         application is chosen by the researcher and the WAVE System can
         automatically introduce the sample, conduct the DNA separation and
         analyze the results. Unlike other techniques, no purification or other
         additional preparation of the DNA sample is necessary. With the
         addition of a fragment collector, the WAVE System will automatically
         collect DNA material for further analysis. The entire process is
         controlled by our

                                       27
<PAGE>
         proprietary WAVEMaker software. This aspect of the WAVE System can
         significantly enhance the productivity of a genomics researcher.

       - DISCOVER NEW MUTATIONS. WAVE System technology can efficiently discover
         new mutations in a sample without prior knowledge of the mutation or
         its location. The WAVE System is uniquely well-suited to the discovery
         of insertions and deletions. Other than sequencing, most genotyping
         methods require prior knowledge of the location of the mutation.
         Compared to sequencing, which requires the interpretation of complex
         reports to detect unknown mutations, the WAVE System displays
         mutations, whether previously known or unknown, as a vertical spike, or
         peak, on a simple graph. The ability to accurately detect the presence
         of mutations allows for the screening of large fragments of DNA without
         time-consuming and cumbersome sequencing of the entire fragment.

       - SCALABILITY. Our bench top WAVE System is scalable depending on the
         research problem to be solved. The DNASep separation columns are
         available in different sizes depending on the application required.

STRATEGY

        We intend to be the leading provider of technology platforms which
enable life science researchers to discover and understand variations in the
human genetic code, or genome, in order to accelerate and improve drug
development and diagnostics. Key elements of our strategy are as follows:

       - FOCUS ON THE GENETIC VARIATION DISCOVERY MARKET. Our current focus is
         to promote the use of our WAVE System by researchers involved in the
         discovery and analysis of genetic variation. The investment in genomics
         research is large and growing, and the corresponding need to analyze
         genetic variations has led to increased demand for new technologies
         such as the WAVE System. We believe the WAVE System significantly
         increases research productivity and may accelerate drug development and
         diagnostics.

       - ESTABLISH THE WAVE SYSTEM AS THE INDUSTRY STANDARD. We are focusing our
         initial marketing efforts on large well-known academic and commercial
         research institutions to establish the WAVE System as the industry
         standard for mutation analysis. We believe we are the first to bring
         high performance DNASep micro-bead technology to the market and have
         sold instruments to key genomics researchers to gain validation of our
         technology, which has resulted in the publication of over 60 articles
         in numerous scientific journals discussing the WAVE System. A key
         component of our strategy is to maintain a worldwide sales organization
         that provides technical support on a local level. We plan to increase
         the number of our sales teams composed of sales personnel, application
         scientists and technical support persons. In addition, because we
         believe that a major factor in ensuring the success of our products is
         to provide qualified technical support on a local level, we expect to
         increase the number of technical support representatives and
         application scientists.

       - INCREASE CONSUMABLE SALES. We expect that our expanding base of
         installed WAVE Systems will result in recurring sales of our associated
         consumable products which include our proprietary columns and reagents.
         Sales of our consumable products over the next five years should
         increase as a proportion of our net sales. In order to support the
         expected increase in consumable sales, we have dedicated manufacturing
         facilities in California, Nebraska and the U.K.

       - PENETRATE NEW MARKETS BY PROVIDING A DIVERSIFIED PORTFOLIO OF
         PRODUCTS. We believe that our WAVE System has potential applications to
         multiple life sciences research markets. We intend to continually
         improve the throughput and otherwise expand the capability of our WAVE
         System to address the varied and changing needs of academic and
         commercial researchers performing specific DNA analysis. We also expect
         to develop separation columns to analyze RNA, amino acids, proteins,
         peptides and carbohydrates. We further intend to provide a range

                                       28
<PAGE>
         of product offerings differentiated by price and throughput levels in
         order to attract the broadest range of customers.

       - BUILD A SUBSTANTIAL INTELLECTUAL PROPERTY ESTATE. We pursue an
         intellectual property strategy of licensing patents and pursuing patent
         protection for our inventions. We own or hold licenses to 11 issued
         U.S. patents and 16 foreign patents. In addition we have pending
         applications for 27 U.S. patents and 10 foreign patents. These issued
         and pending patents are directed at our DNA and related research
         technologies, and cover separation chemistry, molecular biology,
         algorithms, instruments and software. We believe that our strong
         intellectual property estate will continue to be an important
         competitive advantage.

OUR TECHNOLOGY AND PRODUCTS

        Our WAVE System is extremely versatile and can essentially eliminate the
use of traditional gels in the molecular biology lab. Our WAVE System can be
utilized in a wide range of applications, including mutation detection,
sized-based double strand DNA analysis and single strand DNA analysis. Our WAVE
System includes the following components:

        - an autosampler (automatically introduces the DNA sample into our WAVE
          instrument)

        - a pump (pumps sample and reagents through the DNASep column and
          instrument)

        - a DNASep column (separates DNA fragments)

        - a column oven (controls the temperature of the DNASep column)

        - a detector (detects and measures DNA coming off the column)

        - a fragment collector (collects high purity DNA fragments of interest)

        - a personal computer and WAVEMaker Software (used for our WAVE
          instrument interface control, experiment design, data collection, data
          analysis, and reporting)

           [DIAGRAM OF COMPONENTS OF WAVE SYSTEM]

        DNA SAMPLE PREPARATION.  A sample of DNA is first extracted from a
biological sample such as tissue or blood. Extraneous proteins are removed from
the DNA sample and the sample is placed into a

                                       29
<PAGE>
multi-well plate. PCR is a process where a target DNA sequence of approximately
500 base pairs is amplified from the biological sample. The DNA sample is
amplified by repeated cycles of heating and cooling, according to a
pre-determined protocol, which normally takes approximately 30 minutes.

        WAVE SYSTEM SAMPLE INTRODUCTION AND SEPARATION PROCESS.  After the
amplification process is completed, the sample plate is inserted directly into
the WAVE System's autosampler. The autosampler takes a small volume of the
sample and injects it into the DNASep column containing the micro-beads. Due to
the chemical affinity of the DNA to the surface chemistry on the micro-beads in
the column, the DNA attaches itself to the micro-beads. After the sample is
injected into the instrument, a mixture of reagent fluids is pumped into the
column at specified reagent concentrations and temperature conditions.

        As the reagents are pumped through the column, DNA fragments are
released and separated from each other. The DNA fragments flow from the DNASep
column and through an ultraviolet or a fluorescence detector, which then
measures and reports the passage of the DNA fragments of interest. Depending on
the application, DNA fragments can be identified and measured to determine
whether they are mutant or normal, or a specific DNA size or type. The
separation and detection process continues until the entire DNA sample mixture
is separated into individual fragments. Any fragment of interest can be
collected for further study.

        MODES OF OPERATION.  DNA can be separated using three different modes by
controlling the oven temperature. These modes include the following:

       - A NON-DENATURING MODE. This mode is for size-based separations and
         under nondenaturing temperatures, it performs sized-based, sequence
         independent fragment separation of double-stranded DNA. Small
         double-strand DNA fragments can be separated and purified from larger
         DNA fragments. In this case, the smaller DNA fragments are released
         from the column first. Larger fragments of DNA are released in
         ascending size order until the entire sample is separated. The
         high-resolution separation and purification of fragments can be used
         for high purity, cloning, sequencing or PCR amplification. Tests that
         are based on fragment length use this mode.

       - A PARTIAL-DENATURING MODE. This mode is for mutation detection. This
         mode of operation involves the separation of fragments under partially
         denaturing, or partially melting, conditions. In this mode the system
         becomes a sensitive, accurate and cost-effective means for screening
         sequence variation. Sequence variation in PCR product creates mutant
         DNA. Mutant and normal DNA melt and separate at different temperatures.
         The DNASep column micro-beads separate lower melting mutant DNA from
         the column first and then separate the higher melting normal DNA.
         Samples that do not contain genetic variation show a single normal DNA
         peak. The presence of genetic variation is detected by identifying the
         presence of a second mutant DNA peak that is present directly in front
         of the normal DNA peak. This mode allows the screening of a large
         number of samples to identify variants; then only the variants need be
         sequenced instead of indiscriminate sequencing of all samples,
         resulting in significant savings of time and cost. Analysis cost for
         this technology is low, while the sensitivity has been reported to
         exceed 95%. This low cost and high sensitivity justifies using the WAVE
         System as a screening tool to replace indiscriminate sequencing of all
         samples.

       - A FULL-DENATURING MODE. This mode is for single-strand DNA and RNA
         analysis. In the full denaturing mode, single-strand DNA or RNA
         molecules can be separated at even higher temperatures. Our oven
         temperatures allow the separation of single-strand DNA and RNA
         according to sequence and size.

        DETECTION.  The standard WAVE System uses ultraviolet, or UV, detection.
UV detection is highly sensitive and can be used for all applications with
standard PCR amplification. By adding fluorescence detection to our system, we
can further decrease the amount of DNA needed for analysis. This makes it
possible to detect fluorescently labeled DNA fragments from extremely low sample
concentrations or from samples with low PCR amplification.

                                       30
<PAGE>
        FRAGMENT COLLECTION.  Purified DNA fragments can be collected for PCR
amplification, sequencing or for cloning. Cloning is a process where bacteria is
used to grow a large amount of certain specified DNA fragments. It is important
that the DNA material used for cloning is very pure so that only the specified
DNA material is found in the bacteria colonies. Amplification and sequencing
also benefit from highly purified DNA fragments.

        WAVEMAKER SOFTWARE.  Our WAVEMaker Software integrates the
instrumentation control and data acquisition functions of the WAVE System. The
software performs several functions including the formatting and presentation of
data. Our WAVEMaker Software provides logical input and output of instrument
data that is easily understood by researchers familiar with conventional
gel-based technology. We are working to further refine the software component of
the WAVE System to make it easier to operate for a broader market of end users.

        WAVEMaker Software enables the user to choose a specific application.
The clear display allows the user to set up the procedure in a matter of
minutes. Customized protocols can easily be created and saved to facilitate
future analyses. Point mutation detection can be performed by importing the
sequence or size of the DNA fragment of interest into WAVEMaker Software.

        The following diagram presents a sample screen taken from our WAVEMaker
Software.

            [PICTURE OF COMPUTER SCREEN SHOWING WAVEMAKER SOFTWARE]

        PRICING.  This integrated WAVE System is priced from $60,000 to $100,000
depending on features and accessories. The price is dependent upon user selected
options, which include fragment collection, various detector configurations and
software versions.

WAVE OPTIMIZED MOLECULAR BIOLOGY CONSUMABLES

        We manufacture several types of DNASep columns and WAVE Optimized
reagents and other consumables used with our WAVE System. As more of the systems
are sold, we expect that the DNASep

                                       31
<PAGE>
columns, chromatography fluids and other consumable items will become an
increasingly significant source of revenue.

        Some consumables are contained and packaged in convenient kits to
increase ease of use and minimize possibility of user error. These kits may be
used in sample preparation or automated instrument operations for particular
applications. By adding different application kits, the WAVE System can perform
various applications.

RESEARCH AND DEVELOPMENT

        Research and development expenses are budgeted at approximately
$6.5 million for the year 2000. Our research and development efforts fall into
several classes: development of new separation media, advanced instrumentation,
advanced software, chemistry of molecular biology testing and specific molecular
biology tests.

        We are developing a WAVE System specifically tailored for the analysis
and purification of RNA. RNA molecules have a similar structure to DNA and are
used to transmit genetic instructions from DNA for protein synthesis and other
life processes occurring in a cell. In this manner, the functions encoded in DNA
are expressed using RNA. The amounts and types of RNA found in a cell indicate
whether genes are expressed or not. Measurement of types and quantities of RNA
determines the function of genes and their relationship to disease. Also, drug
treatments can be based on direct interaction of the drug on RNA or on the
proteins produced by the RNA. For this reason, many genetic-based drugs being
researched are based on interaction with RNA. Therefore, we believe that RNA
research creates an important opportunity for us in future development of the
WAVE System.

        Determining the cause of disease by studying RNA will require better
tools for RNA analysis than those currently available. Since the function of RNA
is either directly or indirectly involved in drug treatment, genetic-based drug
development will also require better tools for the separation and measurement of
RNA. RNA presents special challenges to the researcher because these molecules
are unstable and difficult to separate and collect. Once separated, RNA is
difficult to keep intact. Therefore, the analysis of RNA can be difficult with
current technologies. We believe the RNA fragment analysis and purification
instrument we are developing has the potential to provide a significant
improvement in the ability to measure and purify RNA. Researchers in the field
of gene expression could use this instrument in their attempt to understand the
correlation of disease and the types and number of genes involved.

SALES AND MARKETING

        We currently sell our WAVE Systems and related consumables in major
geographical markets. We target the U.S., the U.K. and most countries in Western
Europe with a direct sales staff of 18 persons. For the rest of the world, we
use a combination of dealers and distributors located in local markets. We also
maintain regionally-based technical support staffs and applications scientists
to support our sales and marketing activities throughout the U.S., Europe and
Japan.

        Our marketing efforts utilize a variety of promotional channels
including print advertisements, scientific conferences, trade shows, and
Internet browser ads. The primary targets of our marketing efforts are life
sciences researchers and medical geneticists in academic and commercial research
institutions.

CUSTOMERS

        As of March 1, 2000, we have sold over 240 WAVE Systems to customers in
20 countries. Our customers include numerous core laboratory facilities and a
number of other leading academic and medical institutions in the U.S. and
abroad, including Harvard University, Stanford University, Baylor University,
University of Chicago, Fred Hutchison Cancer Research Facility, Mayo Clinic,
National Cancer Institute, National Institutes of Health, Institut Curie,
University of Cambridge, Welcome Trust-Oxford University

                                       32
<PAGE>
and Institut Gustave Roussy. Customers also include a number of large,
established U.S. and foreign pharmaceutical and biotech companies including
SmithKline Beecham, Bristol-Meyers Squibb, Millennium Pharmaceuticals, Merck &
Company, Novartis and Eli Lilly and Company. No single customer accounted for
more than 3% of our sales in 1999.

MANUFACTURING

        We manufacture all of our consumable products including our proprietary
DNASep separation columns and liquid reagents. We also incorporate our own
modifications into the basic liquid chromatography instrument that we use in our
WAVE System. Our manufacturing facilities are located in San Jose, California,
Omaha, Nebraska, and Crewe, England.

        We obtain the basic liquid chromatography instrument for our WAVE System
from Hitachi Instruments, Inc. This relationship allows us to use Hitachi's
significant manufacturing capability to meet potential future increases in
demand for the WAVE System without investing in expanding our own manufacturing
capacity.

        Although our relationship with Hitachi has existed since 1997, we have
recently entered into a new supply agreement with Hitachi under which they will
cooperate with us in the co-development of a modified instrument for use in our
WAVE System. Under the agreement, we have the exclusive right to market any
co-developed products for DNA analysis and purification using our DNASep
technologies. In addition, the agreement will provide for fixed pricing of the
liquid chromatography instruments for our WAVE System. Our agreement with
Hitachi has no fixed term and we have retained the right to work with other
vendors for liquid chromatography instruments. Under the agreement, there will
be no transfer of intellectual property rights without a specific agreement to
do so.

LEGAL PROCEEDINGS

        We are not a party, nor are any of our assets or properties subject, to
any material legal proceedings.

INTELLECTUAL PROPERTY

        To establish and protect our proprietary technologies and products, we
rely on a combination of patent, copyright, trademark and trade-secret laws, as
well as confidentiality provisions in our contracts.

        We have implemented an aggressive patent strategy designed to provide us
with freedom to operate and facilitate commercialization of our current and
future products. We currently own 10 issued patents in the United States and
have 27 pending applications, of which we have received notices of allowances
for four. We also own 16 foreign issued patents, with 10 pending foreign
applications. We hold an exclusive license for components of the DNA separation
technology used in our WAVE System under an agreement with the inventors. This
license terminates in 2013. We have also entered into a non-exclusive license
agreement with a U.S. university relating to DNA detection technology.

        The DNASep column and the systems with which it is combined are DNA
compatible. The micro-beads used within the DNASep column are covered by U.S.
Patent No. 5,585,236 and corresponding European patents. DNA compatible systems
are free from materials which would bind with DNA and interfere with the
separations. Separating DNA with DNA compatible systems and related processes
are covered by U.S. Patents 5,772,889, 5,997,742, 5,997,222, 6,017,457 and
6,024,878, along with a corresponding foreign patent application pending.
Additional patent applications for the DNA compatible column and system are
pending in the U.S., Europe and Japan. Future products including disposable
nucleic acid separation systems are covered by U.S. Patent 5,986,085 and pending
U.S. and foreign patent applications.

                                       33
<PAGE>
        Generally, U.S. patents have a term of 17 years from the date of issue
for patents issued from applications filed with the U.S. Patent Office prior to
June 8, 1995, and 20 years from the application filing date or earlier claimed
priority date in the case of patents issued from applications filed on or after
June 8, 1995. Patents in most other countries have a term of 20 years from the
date of filing the patent application. Our issued United States patents will
expire between 2009 and 2017. Our success depends to a significant degree upon
our ability to develop proprietary products and technologies. We intend to
continue to file patent applications as we develop new products and
technologies.

        Patents provide some degree of protection for our intellectual property.
However, the assertion of patent protection involves complex legal and factual
determinations and is therefore uncertain. The scope of any of our issued
patents may not be sufficiently broad to offer meaningful protection. In
addition, our issued patents or patents licensed to us may be successfully
challenged, invalidated, circumvented or unenforceable so that our patent rights
would not create an effective competitive barrier. Moreover, the laws of some
foreign countries may not protect our proprietary rights to the same extent as
do the laws of the United States and Canada. In addition, the laws governing
patentability and the scope of patent coverage continue to evolve, particularly
in areas of interest to us. As a result, there can be no assurance that patents
will issue from any of our patent applications or from applications licensed to
us. In view of these factors, our intellectual property positions bear some
degree of uncertainty.

        We also rely in part on trade-secret protection of our intellectual
property. We attempt to protect our trade secrets by entering into
confidentiality agreements with third parties, employees and consultants. Our
employees and consultants also sign agreements requiring that they assign to us
their interests in patents and copyrights arising from their work for us. All
employees sign an agreement not to compete unfairly with us during their
employment and after termination of their employment, through the misuse of
confidential information, soliciting employees, soliciting customers and the
like. However, it is possible that these agreements may be breached or
invalidated and if so, there may not be an adequate corrective remedy available.
Despite the measures we have taken to protect our intellectual property, we
cannot assure you that third parties will not independently discover or invent
competing technologies, or reverse engineer our trade secrets or other
technologies. Therefore, the measures we are taking to protect our proprietary
rights may not be adequate.

        We do not believe that our products infringe on the intellectual
property rights of any third party. However, third parties may file claims
asserting that our technologies or products infringe on their intellectual
property. We cannot predict whether third parties will assert claims against us
or against the licensors of technology licensed to us, or whether those claims
will be found to have merit. If we are forced to defend against such claims,
whether they are with or without any merit, whether they are resolved in favor
of or against us or our licensors, we may face costly litigation and diversion
of management's attention and resources. As a result of such disputes, we may
have to develop costly non-infringing technology or enter into licensing
agreements. These agreements, if necessary, may be unavailable on terms
acceptable to us, or at all, which could seriously harm our business or
financial condition.

COMPETITION

        The market for our products is highly competitive. Our principal
competitors include those entities that provide alternative technologies and
products for the separation and analysis of DNA in the areas of sample
amplification, analysis process, sample separation and mutation detection and
correlation. They include Affymetrix, Inc., Agilent Technologies, Amersham
Pharmacia Biotech AB, Bio-Rad Laboratories, Inc., BioWhittaker Molecular
Applications, GeneTrace Systems, Inc., Invitrogen Corporation, PE Corporation,
Sequenom, Inc. and Varian Associates Inc. Moreover, competitors have greater
name recognition than we do and provide more conventional technologies and
products with which some of our customers and potential customers may have more
familiarity or experience. In many cases, in order to compete against existing
and alternative technologies, we will need to demonstrate the superior

                                       34
<PAGE>
performance, speed and capabilities of our WAVE System, including our
proprietary DNASep column and micro-bead technology. We cannot assure you that
we will be able to make the necessary enhancements to our technology or products
to compete successfully with newly emerging technologies.

EMPLOYEES

        As of March 10, 2000, we had 215 full-time employees. Of these
employees, 162 were in life sciences and the remaining 53 were employed in
non-life sciences line product. Of these 215 employees, 41 held Ph.D.s. Upon
closing of the sale of the assets of our non-life sciences instrument product
lines, the non-life sciences instruments employees will become employees of the
purchaser. The following sets forth the number of persons employed in the
principal areas of our operation:

<TABLE>
<CAPTION>
                                                                                             NON-LIFE
                                                                                             SCIENCES
                                                             CONSOLIDATED   LIFE SCIENCES   INSTRUMENT
                                                             ------------   -------------   ----------
<S>                                                          <C>            <C>             <C>
Manufacturing..............................................       55             28             27
Sales and Marketing........................................       71             62              9
Research and Development...................................       59             48             11
Administration.............................................       30             24              6
</TABLE>

        Our future success depends on our continuing ability to attract, train
and retain highly qualified technical, sales and managerial personnel.
Competition for these personnel is intense. Due to the limited number of people
available with the necessary technical skills, we can give no assurance that we
can retain or attract key personnel in the future. None of our employees is
represented by a labor union. We have not experienced any work stoppages and
consider our relations with our employees to be good.

PROPERTIES

        We do not own any real property. We currently lease office and
manufacturing space in the following locations:

<TABLE>
<CAPTION>
LOCATION                                             SQUARE FOOTAGE      ANNUAL RENT      LEASE TERM EXPIRES
- --------                                             --------------   -----------------   ------------------
<S>                                                  <C>              <C>                 <C>
Omaha, Nebraska(1).................................      71,799                $308,000          2000
San Jose, California...............................      13,660                $213,000          2002
Crewe, England.....................................       7,400                 L70,000          2006
Cramlington, England...............................       8,200                 L26,000          2001
Tokyo, Japan.......................................       1,000              Y7,293,000          2001
Cambridge, Massachusetts...........................       2,500                 $54,000          2002
Gaithersburg, Maryland.............................       2,294                 $35,000          2004
Dallas, Texas......................................         240                 $11,000          2000
Houston, Texas.....................................       2,760                 $24,000          2003
</TABLE>

- ------------------------

(1)   In connection with the sale of the assets of our non-life sciences
    instrument product line, the lease for the Omaha, Nebraska facility will be
    assigned to, and assumed by, the purchaser. We intend to relocate our
    headquarters to new administrative offices in the Omaha area.

                                       35
<PAGE>
                                   MANAGEMENT

DIRECTORS, EXECUTIVE OFFICERS AND KEY EMPLOYEES

        Our executive officers and directors, positions held by them and their
ages, as of March 10, 2000, are as follows:

<TABLE>
<CAPTION>
NAME                                          AGE                       POSITION
- ----                                        --------                    --------
<S>                                         <C>        <C>
Collin J. D'Silva.........................     43      Chairman of the Board, Chief Executive
                                                       Officer and Director
John L. Allbery...........................     41      Chief Financial Officer, Treasurer and
                                                       Managing Director of European Operations
Douglas T. Gjerde, Ph.D...................     46      Chief Scientific Officer and Director
John E. Doyle.............................     56      Executive Vice President of Operations
Andrew T. Zander, Ph.D....................     54      Vice President of Research and Development
Kraig McKee...............................     42      Vice President of United States Sales
William Walker............................     64      Vice President of Intellectual Property
Mitchell L. Murphy........................     44      Controller and Secretary
Stephen F. Dwyer..........................     57      Director
Jeffrey Sklar, M.D., Ph.D.................     49      Director
Parag Saxena..............................     44      Director
Gregory J. Duman..........................     44      Director
Roland J. Santoni.........................     58      Director
</TABLE>

        COLLIN J. D'SILVA.  Mr. D'Silva has served as our Chairman of the Board
and Chief Executive Officer since 1997 and is also a Director. Mr. D'Silva, a
co-founder of Transgenomic, has worked for Transgenomic and its predecessors
since 1988. Prior to that time, Mr. D'Silva was employed by AT&T from 1980. At
AT&T, he held various positions in engineering, materials management, sales
support and business development. His last position at AT&T was Business Unit
Manager and Engineering Manager for a network distribution products division.
Mr. D'Silva holds a B.S. degree and a M.Eng. degree in industrial engineering
from Iowa State University and an M.B.A. from Creighton University.

        JOHN L. ALLBERY.  Mr. Allbery joined us in March, 2000 as Chief
Financial Officer, Treasurer and Managing Director of European Operations. Prior
to joining us, Mr. Allbery served as the Chief Financial Officer and Managing
Director of the Virtus Group in Central and Eastern Europe since 1999. From 1985
until 1999, Mr. Allbery was with the accounting firm of Deloitte & Touche LLP
and served in various positions including office Partner-In-Charge of Tax and
Legal in Central Europe.

        DOUGLAS T. GJERDE, PH.D.  Dr. Gjerde joined us in 1996 as Chief
Scientific Officer. Dr. Gjerde has held positions as senior scientist for Exxon
Research and Engineering, Director of Research for Wescan Instruments, and
President and Director of Research & Development for Sarasep, Inc. Sarasep,
which Dr. Gjerde co-founded, was acquired by us in 1996. Dr. Gjerde has authored
12 patents and has more than 40 journal publications, primarily focused on
separation technology. Dr. Gjerde received his B.S. in chemistry in 1976 from
Minnesota State University, Mankato, Minnesota, and his Ph.D. in analytical
chemistry in 1980 from Iowa State University, Ames, Iowa.

        JOHN E. DOYLE.  Mr. Doyle has been with our company since
September 1997, initially focusing on operations and process improvement. In
1999, Mr. Doyle assumed responsibility for sales, again focusing on process as
well as improvements in staffing. Prior to joining Transgenomic, he was with
Supelco Inc. for 20 years, serving as Chief Executive Officer when it was a
Sigma-Aldrich company; Business Unit Vice President when it was a subsidiary of
Rohm and Haas Corporation; and International Vice President when it was
privately held. Mr. Doyle received his engineering degree from Pennsylvania
State University.

                                       36
<PAGE>
        ANDREW T. ZANDER, PH.D.  Dr. Zander has served as our Vice President of
Research and Development since April 1999. Prior to joining Transgenomic,
Dr. Zander held the position of Director of the Measurements Laboratory in the
corporate research center of Varian Associates, Inc. from November 1987 to
April 1999. Additionally, Dr. Zander just completed 30 years of commissioned
service with the U.S. Naval Reserve, holding the rank of Captain, and including
21 years as Scientific Liaison Officer with the Office of Naval Research in the
Chemistry and Chem/Bio Defense Programs. Dr. Zander holds a Ph.D. from the
University of Maryland.

        KRAIG MCKEE.  Mr. McKee has served as our Vice President of Sales for
the United States since July 1999. Prior to joining us, he was the Sales
Director from 1997 to 1999 for Bayer Diagnostics. From 1987 through 1997, he
held a number of positions in the sales organization of Chiron Diagnostics. His
last position at Chiron was National Sales Director, ACS Reagent Systems. He
received a Bachelor's degree in marketing from Texas Tech University.

        WILLIAM WALKER.  Mr. Walker joined us in 1998 as Vice President of
Intellectual Property. Mr. Walker is a corporate attorney with an emphasis in
intellectual property law. Mr. Walker served as Director of Patents and
Licensing for Syntex Corporation (1970-1981) and subsequently provided
intellectual property counseling to new and emerging companies. Mr. Walker has a
law degree from Georgetown University Law Center, a B.S. degree in chemical
engineering from the University of Tennessee and a MFCC degree in psychology
from Santa Clara University. He is a member of the California Bar and is active
in numerous professional organizations.

        MITCHELL L. MURPHY.  Mr. Murphy joined us in 1992. His current duties
include the overall administration of our finance and accounting functions.
Prior to joining Transgenomic, he held accounting and financial management
positions for companies involved in manufacturing, steel distribution and rebar
fabrication for 15 years. He spent over two years as an auditor for the Omaha,
Nebraska office of Deloitte, Haskins & Sells (now Deloitte & Touche LLP) working
in a broad range of industries. Mr. Murphy graduated with honors from Creighton
University in 1978 with a B.S. degree in business administration with an
accounting major.

        STEPHEN F. DWYER.  Mr. Dwyer has recently signed a letter of intent to
acquire the assets associated with our non-life sciences instrument product
line, which will be operated as a separate business. Mr. Dwyer is a director and
was a co-founder of Transgenomic. From 1996 until March 2000, Mr. Dwyer was
employed by Transgenomic and its predecessor company, most recently as Vice
Chairman. In 1966, Mr. Dwyer started Sasco Inc., which produced laboratory
animals used in disease research. In 1986, Mr. Dwyer sold Sasco to Charles River
Labs. He continued to run Sasco as a Charles River Labs subsidiary for the next
eight years.

        JEFFREY SKLAR, M.D., PH.D.  Dr. Sklar is professor of Pathology at
Harvard Medical School, where he has been on the faculty for more than five
years. He also serves as Director of the Divisions of Diagnostic Molecular
Biology and Molecular Oncology, department of Pathology Brigham and Women's
Hospital. Dr. Sklar serves on the Editorial Boards of Numerous Journals in the
area of Pathlogy and Cancer and on Scientific Advisory Committees to the
Dana-Farber Cancer Center, Boston, MA; the Fred Hutchinson Cancer Center,
Seattle, Washington; the New England Regional Primate Center; Harvard
University; and the National Institutes of Health. He is a director of Dianon
Systems, Inc., and has served on the scientific advisory boards of numerous
companies in the biotechnology field. Dr. Sklar holds an M.D. and Ph.D. from
Yale University and an M.A. (honorary) from Harvard University.

        PARAG SAXENA.  Mr. Saxena is the Chief Executive Officer of INVESCO
Private Capital, Inc. ("IPC") and has held that position for more than five
years. As a founding member of IPC, Parag has been involved in numerous private
capital transactions and has served as a director on a number of venture-backed
healthcare and telecommunications companies. Mr. Saxena began his career in 1978
as a product engineer at Becton Dickinson Corporation. He later joined Booz,
Allen and Hamilton in the Technology Management Services Group where his
responsibilities included market analysis, technology strategy, acquisition
evaluation and business strategy formulation for several Fortune 100
corporations in

                                       37
<PAGE>
the healthcare field. Mr. Saxena joined Citicorp Investment Management, Inc. in
1983 as a founding member of the private capital group's predecessor and was
responsible for healthcare private investments and small cap public stocks.
Mr. Saxena received a B. Tech in 1977 from the Indian Institute of Technology
and an M.S. in 1978 in Chemical Engineering from West Virginia College of
Graduate Studies. He earned an M.B.A. in 1982 from the Wharton School of the
University of Pennsylvania.

        GREGORY J. DUMAN.  Mr. Duman has been a director since March 2000.
Mr. Duman is the Executive Vice President of Transaction Systems
Architects, Inc. (TSAI) a computer software company. He joined TSAI in 1983 as
Director of Administration. He became Controller in 1985 and Vice President of
Finance and Chief Financial Officer in 1991 and served in that role through
February 2000. From 1979 to 1983, he worked for Arthur Andersen & Co. as a
certified public accountant Mr. Duman is a director of Nestor, Inc. (Nasdaq:
NEST) and Digital Courier Technologies, Inc. (Nasdaq: DCTI).

        ROLAND J. SANTONI.  Mr. Santoni has been a director since March 2000. He
has been Professor of Law at Creighton University School of Law, Omaha, Nebraska
since 1977. He also has been Of Counsel with Erickson & Sederstrom, P.C. since
1978. Mr. Santoni received a B.S. in Economics from The Wharton School,
University of Pennsylvania, in 1963 and a J.D., CUM LAUDE, from the University
of Pennsylvania School of Law in 1966.

SCIENTIFIC ADVISORS

        We consult with several leading scientists from around the world, as
part of our ongoing research and development efforts. These advisors assist us
in formulating our research, development, and commercialization strategies. Some
of these advisors include:

        - Dennis R. Burton, Ph.D., Professor of Immunology, The Scripps Research
          Institute, La Jolla, California.

        - R. Alan North, Ph.D., Professor and Director of the Institute of
          Molecular Physiology, the University of Sheffield, Sheffield, U.K.

        - Eric Hoffman, Ph.D., Director, Research Center for Genetic Medicine,
          The Children's National Medical Center, Washington, D.C.

        - Leon Yengoyan, Ph.D., Professor of Chemistry, San Jose State
          University, San Jose, California.

        We do not pay cash remuneration to our scientific advisors, but may
reimburse them for reasonable expenses they incur on our behalf. We may also
award stock options to them under our stock option plan. See "Stock Option and
Other Compensation Plans" below.

BOARD OF DIRECTORS

        Our Board of Directors is comprised of seven directors and is divided
into three classes. Directors of each class are elected for terms of three
years. Class I directors are Parag Saxena and Collin J. D'Silva. Class II
directors are Stephen F. Dwyer and Jeffrey Sklar. Class III directors are
Douglas T. Gjerde, Gregory Duman and Roland J. Santoni. The current terms of the
Class I, Class II and Class III directors will end at our annual stockholders
meetings held in 2001, 2002 and 2003, respectively.

BOARD COMMITTEES

        The audit committee consists of Messrs. Duman, Sklar and Saxena, each of
whom is an independent director. The audit committee reviews the services
provided by our independent auditors, consults with the auditors on audits and
proposed audits, and reviews and evaluates our internal auditing procedures and
control functions.

        The compensation committee consists of Messrs. Sklar, Dwyer and Saxena.
The compensation committee reviews the compensation arrangements for our
executive officers, makes recommendations to the Board of Directors regarding
compensation matters and administers our employee stock option plan. See "Stock
Option and Other Compensation Plans" below.

                                       38
<PAGE>
DIRECTOR COMPENSATION

        Directors who are also our officers are not separately compensated for
serving on the Board of Directors other than reimbursement for out-of-pocket
expenses related to attendance at board and committee meetings. Outside
directors are paid an annual retainer of $12,000. In addition, they receive a
fee of $1,200 for attending meetings in person, or $600 for participating in a
meeting by teleconference, as well as reimbursement for out-of-pocket expenses
related to attendance at board and committee meetings.

        Outside directors are issued options to purchase 15,000 shares of common
stock under our 1997 Stock Option Plan upon initial appointment to the board.
The options have exercise prices ranging from the lesser of $5.00 per share or
50% of the price that we issue common stock in this offering to $10.00 per
share. These options vest at the rate of 20% per year of service on the board.

COMPENSATION COMMITTEE INTERLOCKS AND INSIDE PARTICIPATION

        No member of our compensation committee serves as a member of the board
of directors or compensation committee of any other company that has one or more
executive officers serving as a member of our board of directors or compensation
committee.

EXECUTIVE COMPENSATION

        The following table sets forth the total compensation we paid during the
year ended December 31, 1999 to our Chief Executive Officer and our next four
most highly compensated executive officers whose salary and bonus for 1999
exceeded $100,000. Also included is the compensation of an executive officer who
resigned prior to the end of the year. These executive officers are referred to
as the named executive officers elsewhere in the prospectus.

                         SUMMARY COMPENSATION TABLE(1)

<TABLE>
<CAPTION>
                                                             ANNUAL COMPENSATION
                                                      ----------------------------------
                                                                            OTHER ANNUAL      ALL OTHER
NAME AND PRINCIPAL POSITION                            SALARY     BONUS     COMPENSATION   COMPENSATION(2)
- ---------------------------                           --------   --------   ------------   ---------------
<S>                                                   <C>        <C>        <C>            <C>
Collin J. D'Silva...................................  $132,440    $    0       $6,129          $21,587
  Chief Executive Officer

William Walker......................................   201,466         0        1,889            5,631
  Vice President of
  Intellectual Property

John E. Doyle.......................................   150,645     4,000        3,615           17,893
  Executive Vice President
  of Operations

Andrew T. Zander, Ph.D..............................   117,378         0        2,101            4,695
  Vice President of Research and Development

Douglas T. Gjerde, Ph.D.............................   101,216         0        3,074           19,394
  Chief Scientific Officer

P. Thomas Pogge.....................................   162,871         0        4,643            8,256
  General Counsel(3)
</TABLE>

- ------------------------

(1)  No long term compensation was awarded or paid to any named executive
     officer during 1999.

(2)  Consists of accrued vacation to be taken in the future or paid in cash upon
     termination of employment.

(3)  Mr. Pogge resigned as an executive officer prior to the end of 1999.

        All executive officers are eligible to participate in our stock option
plan (described under "Stock Option and Other Compensation Plans") and may
participate in other employee benefit plans and programs, such as health
insurance plans, that we offer to our other employees.

                                       39
<PAGE>
OPTION GRANTS IN LAST FISCAL YEAR

        None of the named executive officers were awarded any stock options
during 1999.

AGGREGATED OPTION EXERCISE IN LAST FISCAL YEAR AND YEAR-END OPTION VALUES

        None of the named executive officers exercised any stock options during
1999.

STOCK OPTION AND OTHER COMPENSATION PLANS

        STOCK OPTION PLAN.  Our stock option plan allows us to grant options to
our employees, directors and advisors which give them the right to buy our
common stock at a fixed price, even if the market value of our stock goes up.
Our stock option plan is administered by the compensation committee of our Board
of Directors and it has the sole authority to set the number, exercise price,
term and vesting provisions of the options granted under the plan. Under the
terms of the plan, the exercise price of an option cannot be less than the fair
market value of our common stock on the date the option is granted. In general,
options will expire if not exercised within ten years from the date they are
granted. The committee may also require that an option holder remain employed by
us for a specified period of time before an option may be exercised. These
"vesting" provisions are established on an individual basis by the committee.
The committee will also decide whether options will be nonqualified options or
structured to be qualified options for U.S. income tax purposes. Either
incentive or nonqualified stock options may be granted to employees, but only
nonqualified stock options may be granted to our non-employee directors and
advisors. Options for a maximum of 6,000,000 shares may be granted under the
plan. To date, we have issued options for 3,724,250 shares of our common stock.
All of these options have an exercise price ranging from $5.00 to $10.00 per
share, except that options for 15,000 shares issued to one of our non-employee
directors may be exercised at the lower of $5.00 per share or 50% of the price
of our common stock in this offering. See "Director Compensation" above.

        Under the terms of our stock option plan, if the option holder dies,
becomes permanently disabled or retires any options not vested at such time will
become immediately vested. If an option holder voluntarily resigns, any options
not vested as of the date of resignation will terminate and all rights will
cease, unless the compensation committee determines otherwise. In the event an
option holder's employment, board membership or status as an advisor is
terminated for cause, the option holder's right to exercise an option, whether
or not vested, will immediately terminate and all rights will cease, unless the
compensation committee determines otherwise.

        EMPLOYEE SAVINGS PLAN.  We have also established an employee savings
plan that is intended to qualify as a tax-qualified plan under Section 401(k) of
the Internal Revenue Code. This plan allows for voluntary contributions up to
statutory maximums by eligible employees. We match a specific proportion of
these contributions, subject to limitations imposed by law. We may make
additional contributions to the savings plan on behalf of our employees if our
Board of Directors decides to do so. During the years ended December 31, 1997,
1998 and 1999, we contributed $92,733, $117,923 and $174,973 to the savings plan
on behalf of our employees.

LIMITATION OF DIRECTORS AND OFFICERS LIABILITY

        Our certificate of incorporation provides that no director will be
liable for monetary damages for breach of the director's fiduciary duty to the
company or its stockholders, except for liability arising from:

        - breach of the director's duty of loyalty to the company or its
          stockholders;

        - acts or omissions not in good faith or involving intentional
          misconduct or knowing violations of law;

        - improper distributions to stockholders and improper redemptions of
          stock; and

        - transactions from which the director derived an improper personal
          benefit.

                                       40
<PAGE>
This provision of our certificate of incorporation does not eliminate the
directors' fiduciary duties, and in appropriate circumstances, equitable
remedies including an injunction or other forms of non-monetary relief would
remain available under Delaware law. This provision also does not affect a
director's responsibilities under any other laws including federal securities
laws or state or federal environmental laws.

        In addition, our bylaws provide that we will indemnify our directors and
officers to the fullest extent permitted by Delaware law. We are also empowered
under our bylaws to enter into indemnification contracts with our directors and
officers and to purchase insurance on behalf of any person we are required or
permitted to indemnify. We have obtained directors and officers liability
insurance coverage which covers, among other things, liabilities arising under
the Securities Act.

EMPLOYMENT AGREEMENTS

        We have entered into employment agreements with our Chief Executive
Officer, Collin J. D'Silva, our Chief Financial Officer, John L. Allbery, our
Chief Scientific Officer, Dr. Douglas T. Gjerde and William Walker, our Vice
President of Intellectual Property. Each employment agreement has an initial
term of five years and will automatically renew for an additional three-year
period unless we or the officer gives notice of an intention not to renew. The
employment agreements require our executives to devote their full time to our
business activities; subject to certain reasonable exceptions. Our executives
are not allowed to compete with us while they are our employees and for a year
after they are no longer our employee. If one of our officers dies or becomes
permanently disabled, he will receive an amount equal to six months of salary,
and if an officer's employment is terminated for reasons other than an act of
serious misconduct, the officer will be entitled to severance pay in an amount
equal to his then current base salary plus the amount of the previous year's
bonus, provided that such severance payment does not exceed 299% of his current
salary.

        Each of our executive officers has also entered into a separate
confidentiality agreement which prohibits them from disclosing confidential
information about our business to people outside of the company except for
proper business purposes.

                                       41
<PAGE>
                             PRINCIPAL STOCKHOLDERS

        The following table provides information concerning beneficial ownership
of our common stock as of March 10, 2000, by:

        - each of our named executive officers;

        - each of our directors;

        - all of our directors and executive officers as a group; and

        - each stockholder that we know owns more than 5% of our outstanding
common stock.

        The following table assumes conversion of $12.0 million of aggregate
principal amount of our convertible notes plus accrued interest at $5.00 per
share into 2,712,200 shares of common stock and 300,000 shares that will be
issued at $5.00 per share upon the exercise of warrants immediately prior to
completion of this offering.

Based on information furnished by such owners, we believe that the beneficial
owners listed below have sole voting and investment power with respect to such
shares.

<TABLE>
<CAPTION>
                                                                                  PERCENT
                                                                            BENEFICIALLY OWNED
                                                                            -------------------
                                                        NUMBER OF SHARES     BEFORE     AFTER
NAME                                                   BENEFICIALLY OWNED   OFFERING   OFFERING
- ----                                                   ------------------   --------   --------
<S>                                                    <C>                  <C>        <C>
EXECUTIVE OFFICERS AND DIRECTORS
Collin J. D'Silva(1).................................       4,470,000         33.5%      22.3%
John L. Allbery(2)...................................          20,000         *          *
Douglas T. Gjerde, Ph.D.(3)..........................       2,500,000         16.9       11.6
John E. Doyle(4).....................................          45,000         *          *
Andrew T. Zander, Ph.D.(5)...........................              --         *          *
Kraig McKee(6).......................................              --         *          *
William Walker(7)....................................          25,000         *          *
Mitchell L. Murphy(8)................................          14,000         *          *
Stephen F. Dwyer(9)..................................       2,986,000         22.4       14.9
Jeffrey Sklar, M.D., Ph.D.(10).......................           9,000         *          *
Gregory Duman(11)....................................          25,000         *          *
Roland J. Santoni(12)................................              --         *          *
Parag Saxena.........................................              --         *          *
All executive officers and directors as a group
  (13 persons).......................................      10,094,000         57.2       46.6
OTHER STOCKHOLDERS
Arthur P. D'Silva(13)................................       1,530,000          9.5        7.6
INVESCO Private Capital, Inc.(14)....................       2,260,167         14.1       11.3
</TABLE>

- ------------------------

*   Less than 1%.

(1)  Includes 1,400,000 shares owned by the Arthur P. D'Silva Trust, of which
     Collin J. D'Silva is the sole trustee.

(2)  Consists of vested options to purchase 20,000 shares at $10.00 per share.
     Mr. Allbery holds unvested options to purchase an additional 80,000 shares
    at $10.00 per share.

(3)  Includes an option to purchase 1,500,000 shares at $5.00 per share.

                                       42
<PAGE>
(4)  Consists of vested options to acquire 45,000 shares at $5.00 per share.
     Mr. Doyle holds unvested options to purchase an additional 30,000 shares at
    $5.00 per share.

(5)  Mr. Zander holds unvested options to purchase 50,000 shares at $5.00 per
     share.

(6)  Mr. McKee holds unvested options to purchase 20,000 shares at $5.00 per
     share.

(7)  Consists of vested options to purchase 25,000 shares at $5.00 per share.
     Mr. Walker holds unvested options to purchase an additional 75,000 shares
    at $5.00 per share.

(8)  Consists of 4,000 shares owned by Mr. Murphy and vested options to purchase
     10,000 shares at $5.00 per share. Mr. Murphy holds unvested options to
    purchase an additional 40,000 shares at $5.00 per share.

(9)  Includes 500,000 shares owned by Nancy A. Dwyer, Mr. Dwyer's wife.

(10)  Consists of vested options to acquire 9,000 shares at the lesser of
     (a) $5.00 per share or (b) 50% of the initial public offering price.
    Dr. Sklar holds unvested options to buy 6,000 additional shares at such
    price.

(11)  Consists of 25,000 shares owned by Mr. Duman. Mr. Duman holds unvested
     options to purchase an additional 15,000 shares at $10.00 per share.

(12)  Mr. Santoni holds unvested options to purchase 17,500 shares at $10.00 per
     share.

(13)  Mr. D'Silva is the father of Collin J. D'Silva. Mr. D'Silva's address is
     Transgenomic, Inc., 5600 South 42nd Street, Omaha, Nebraska 68107.

(14)  INVESCO's address is 1166 Avenue of the Americas, New York, New York 10036

                                       43
<PAGE>
                           RELATED PARTY TRANSACTIONS

        In March 2000, we signed a letter of intent with Stephen F. Dwyer, a
director and a principal stockholder of ours, under which Mr. Dwyer has agreed
to acquire the assets related to our non-life sciences instrument product lines
for a total purchase price of $6,000,000, of which $5,000,000 will be paid in
cash and $1,000,000 will be paid with an interest-bearing promissory note due on
March 31, 2001. The note bears interest at a market rate. The sale of these
assets is expected to occur on March 31, 2000, subject to the approval of our
stockholders. The purchase price and other terms of the transaction were
determined through negotiation between us and Mr. Dwyer and was approved by our
disinterested directors. An unaffiliated party recently made a written offer of
$4,000,000 for these assets.

        Collin J. D'Silva, Stephen F. Dwyer and Douglas T. Gjerde were partners
of CT Partners, an Iowa general partnership, along with various other
individuals, some of whom are relatives of Mr. D'Silva and Mr. Dwyer.
Mr. D'Silva, Mr. Dwyer and Dr. Gjerde held partnership interests of 28.6%, 23.8%
and 4.8%, respectively, in CT Partners. In 1997, our predecessor company agreed
to provide CT Partners with research and development services to assist CT
Partners in the development of certain miniature solid-state optical
spectrometry technologies to which it held the rights. Our predecessor company
was entitled to a fee for these services and for reimbursement of its expenses.
In addition, our predecessor company entered into a royalty agreement with CT
Partners under which it received an exclusive license to manufacture and market
this technology and agreed to pay CT Partners a royalty of up to $6,500,000
based on the sales of products employing this technology. On June 3, 1999, we
acquired the rights to this technology from CT Partners for a purchase price of
$2,000,000. The purchase price was offset by the cancellation of principal and
interest due on promissory notes given to us by CT Partners in payment of the
fees and expense reimbursements owed to us by it. Principal and interest on
these notes plus additional accrued expenses equaled $1,085,931. The sale price
was based on the present value of anticipated future net income from the sale of
products associated with the technology. The royalty agreement was cancelled as
a result of the sale of the technology rights by CT Partners to us. We will sell
the rights to this technology in connection with the sale of assets related to
the non-life sciences instrument product line described above.

                                       44
<PAGE>
                          DESCRIPTION OF CAPITAL STOCK

GENERAL

        We can issue up to 60,000,000 shares of our common stock and 15,000,000
shares of our preferred stock. There are currently 13,025,000 shares of our
common stock outstanding. This number will increase to 16,037,200 assuming
conversion of our convertible notes and accrued interest thereon and the
exercise of 300,000 warrants to purchase our common stock that will expire at
the closing of this offering. We have not issued any shares of preferred stock.
You should read the following summary description of our capital stock in
conjunction with our certificate of incorporation and our bylaws, each of which
is available upon request.

COMMON STOCK

        The holders of our common stock are entitled to

        - one vote per share on all matters submitted to a vote of our
          stockholders;

        - the payment of any dividends declared by the Board of Directors out of
          legally available funds, after the superior rights of any preferred
          stock holders have been satisfied; and

        - share ratably in company assets available for distribution to them in
          the event of the liquidation, dissolution, distribution of assets or
          winding up of the company.

        The holders of common stock do not have cumulative voting rights. As a
result, the holders of a majority of the outstanding common stock can elect all
the directors of the company. The remaining common stock holders will not be
able to elect any directors. The holders of common stock have no preemptive or
other subscription rights, and there are no conversion, redemption or sinking
fund provisions with respect to the common stock. All outstanding shares of
common stock are, and all shares of common stock to be outstanding upon
completion of this offering will be, fully paid and non-assessable. The common
stock has a par value of $0.01 per share.

PREFERRED STOCK

        The Board of Directors is authorized to issue up to 15,000,000 shares of
preferred stock in one or more series and to fix the rights, powers,
preferences, qualifications, limitations and restrictions granted to or imposed
on the preferred stock. The authority of the Board of Directors includes the
right to fix dividend rights, conversion rights, terms of redemption,
liquidation preference, sinking fund terms and the number of shares constituting
any series or the designation of a series, without any further vote or action by
the stockholders. The preferred stock may be issued with a preference over the
common stock as to the payment of dividends. The Board of Directors, without
stockholder approval, can issue preferred stock with voting and conversion
rights that could adversely affect the voting power of the holders of common
stock. The issuance of preferred stock could have the effect of delaying,
deferring or preventing a change in control of Transgenomic. For the foregoing
reasons, any preferred stock we issue could adversely affect your rights as a
holder of our common stock. We do not have any present plans to issue preferred
stock.

WARRANTS

        As of the date of this prospectus, we have issued 452,450 warrants to
purchase common stock at an exercise price equal to the lower of $5.00 per share
or 50% of the offering price of the common stock in this offering. Of this
total, 300,000 warrants will expire upon the closing of this offering and the
rest will expire in 2003. All of the warrants contain provisions for the
adjustment of the exercise price and the aggregate number of shares that may be
issued upon the exercise of the warrant if a stock dividend, stock split,
reorganization, reclassification or consolidation occurs.

                                       45
<PAGE>
OPTIONS

        As of the date of this prospectus, we have issued options to purchase
3,724,250 shares of our common stock at an exercise price ranging from $5.00 to
$10.00 per share, except that options for 15,000 shares issued to one of our
non-employee directors may be exercised at the lower of $5.00 per share or 50%
of the price of our common stock in this offering. Additional options to acquire
2,275,750 shares of common stock may be issued in the future under our Stock
Option Plan.

CONVERTIBLE NOTES

        In March 1999, we issued $12,000,000 of our convertible notes to a group
of investors. The convertible notes will be due and payable in March 2002.
Interest on the notes compounds at 6% per annum until maturity or until we
complete an underwritten public offering of our common stock which provides us
with net proceeds of not less than $15 million. Interest will be payable either
in cash upon repayment of the notes at or after the maturity date, or if
elected, upon the completion of this offering all accrued and unpaid interest
shall be converted into shares of common stock. The interest rate after this
offering for notes that are not converted shall be reduced to 3.6%, and interest
shall become due for the remainder of the term through the maturity date at the
closing of this offering.

        The convertible notes may be converted into shares of our common stock
at or after the time we make an underwritten public offering of our common stock
which provides us with net proceeds of not less than $15 million. Accordingly,
these conversion rights may be exercised by the holders of the convertible notes
when we close this offering. If this offering is completed before September 25,
2000, the conversion price per share will be the lower of (i) $5.00 or (ii) 50%
of the public offering price of shares in this offering. If this offering is
completed after that date, the conversion price may be reduced depending on the
length of the delay. In addition, if certain events were to occur prior to the
completion of this offering, the note holders will have the right to convert
their notes into stock. These events include a merger, a sale of all assets,
certain change of control events and a liquidation of the company. The number of
shares to be issued upon a conversion in one of these cases will be the greater
of (i) the number determined by dividing principal and accrued interest on the
notes by $5.00 or (ii) the number determined having an aggregate value equal to
200% of principal and accrued interest on the notes. The value of our common
stock used in this calculation will be determined by the amount realized by our
stockholders from the merger, sale of assets, change of control or liquidation
transaction. Finally, if Collin D'Silva were to sell any of his shares before
this offering, the note holders have the right to convert notes into common
stock at $5.00 per share. We do not anticipate that any merger, sale of assets,
change of control or liquidation transaction will occur prior to the closing of
this offering or that Mr. D'Silva will sell any shares of his stock prior to
that time.

        If the note holders do not convert their convertible notes after the
completion of this offering, we may elect to convert their notes if at any time
the total of (i) the average closing bid price for our common stock over 20
consecutive trading days and (ii) accrued interest on the notes (when converted
into an amount per share using the conversion price then in effect) equals or
exceeds $13.72 per share.

        In connection with the issuance of the convertible notes, Collin D'Silva
has agreed to vote his shares at any meeting of the stockholders to cause a
person designated by the holders of the convertible notes to be elected to our
Board of Directors. We have also agreed that the director designated by the
convertible note holders will be a member of our compensation and audit
committees.

                                       46
<PAGE>
ANTI-TAKEOVER PROVISIONS OF DELAWARE LAW AND CHARTER PROVISIONS

    DELAWARE LAW.

        In general, Section 203 of the Delaware General Corporation Law
prohibits a publicly held Delaware corporation from engaging in any business
combination with any interested stockholder for a period of three years
following the date that the stockholder became an interested stockholder unless:

        - prior to that date, the Board of Directors of the corporation approved
          either the business combination or the transaction that resulted in
          the stockholder becoming an interested stockholder;

        - upon consummation of the transaction that resulted in the
          stockholder's becoming an interested stockholder, the interested
          stockholder owned at least 85% of the voting stock of the corporation
          outstanding at the time the transaction commenced, excluding those
          shares owned by persons who are directors and also officers, and
          employee stock plans in which employee participants do not have the
          right to determine confidentially whether shares held under the plan
          will be tendered in a tender or exchange offer; or

        - on or subsequent to that date, the business combination is approved by
          the Board of Directors and authorized at an annual or special meeting
          of stockholders, and not by written consent, by the affirmative vote
          of at least two-thirds of the outstanding voting stock that is not
          owned by the interested stockholder.

        Section 203 defines "business combination" to include:

        - any merger or consolidation involving the corporation and the
          interested stockholder;

        - any sale, transfer, pledge or other disposition involving the
          interested stockholder of 10% or more of the assets of the
          corporation;

        - in general, any transaction that results in the issuance or transfer
          by the corporation of any stock of the corporation to the interested
          stockholder; or

        - the receipt by the interested stockholder of the benefit of any loans,
          advances, guarantees, pledges or other financial benefits provided by
          or through the corporation.

        In general, Section 203 defines an interested stockholder as any entity
or person beneficially owning 15% or more of the outstanding voting stock of the
corporation and any entity or person affiliated with or controlling or
controlled by the entity or person.

    CHARTER PROVISIONS.

        Our Certificate of Incorporation and Bylaws include a number of
provisions that may have the effect of deterring hostile takeovers or delaying
or preventing changes in control or management of Transgenomic. First, our
certificate of incorporation provides that all stockholder actions must be
effected at a duly called meeting of holders and not by a consent in writing.
Second, our bylaws provide that special meetings of the holders may be called
only by the chairman of the Board of Directors, the Chief Executive Officer or
our Board of Directors pursuant to a resolution adopted by a majority of the
total number of authorized directors. Third, our certificate of incorporation
provides that our Board of Directors can issue up to 15,000,000 shares of
preferred stock, as described under "Preferred Stock" above. Fourth, our
certificate of incorporation and the Bylaws provide for a classified Board of
Directors in which approximately one-third of the directors would be elected
each year. Consequently, any potential acquirer would need to successfully
complete two proxy contests in order to take control of the Board of Directors.
As a result of the provisions of the certificate of incorporation and Delaware
law, stockholders will not be able to cumulate votes for directors. Finally, our
bylaws establish procedures, including advance notice procedures with regard to
the nomination of candidates for election as directors and stockholder
proposals.

                                       47
<PAGE>
These provisions of our certificate of incorporation and bylaws could discourage
potential acquisition proposals and could delay or prevent a change in control
or management of our company.

TRANSFER AGENT AND REGISTRAR

        Norwest Bank, Omaha, Nebraska, has been appointed as the transfer agent
and registrar for our common stock.

NATIONAL MARKET LISTING

        We have applied for listing of our common stock on the Nasdaq Stock
Market's National Market under the symbol TBIO.

                                       48
<PAGE>
                        SHARES ELIGIBLE FOR FUTURE SALE

        Sales of substantial amounts of our common stock in the public market
after the offering could adversely affect the market price of our common stock
and our ability to raise equity capital in the future on terms favorable to us.

        After this offering, 20,037,200 shares of our common stock will be
outstanding, assuming conversion of our convertible notes and accrued interest
thereon and the exercise of warrants to acquire 300,000 shares of common stock
that will expire at the closing of this offering and also assuming that the
underwriters do not exercise the over-allotment option. Of these shares, all of
the 4,000,000 shares sold in this offering will be freely tradable without
restriction or further registration under the Securities Act, unless these
shares are purchased by "affiliates" as that term is defined in Rule 144 under
the Securities Act. The remaining 16,037,200 shares of common stock held by
existing stockholders are "restricted securities" as that term is defined in
Rule 144 under the Securities Act. Restricted securities may be sold in the
public market only if registered or if they qualify for an exemption from
registration under Rules 144 or 701 under the Securities Act, which rules are
summarized below.

        The following table indicates approximately when the 16,037,200 shares
of our common stock that are not being sold in this offering but which will be
outstanding when this offering is complete will be eligible for sale in the
public market:

                        ELIGIBILITY OF RESTRICTED SHARES
                         FOR SALE IN THE PUBLIC MARKET

<TABLE>
<S>                                                           <C>
At effective date...........................................
At or before 90 days after the effective date...............
At or before 180 days after the effective date..............
</TABLE>

        Most of the restricted shares that will become available for sale in the
public market starting 180 days after the effective date will be subject to
volume and other resale restrictions under Rule 144 because the holders are our
affiliates.

RULE 144

        In general, under Rule 144 as currently in effect, beginning 90 days
after the date of this prospectus, a person who has beneficially owned shares of
our common stock for at least one year, including any affiliate of ours, is
entitled to sell, within any three-month period, a number of shares that is not
more than the greater of:

        - 1% of the number of shares of common stock then outstanding, which
          will equal approximately 200,372 shares immediately after this
          offering; or

        - the average weekly trading volume of the common stock on the Nasdaq
          National Market during the four calendar weeks before a notice of the
          sale on Form 144 is filed.

        Sales under Rule 144 are also subject to manner of sale provisions and
notice requirements and to the availability of current public information about
us.

RULE 144(K)

        Under Rule 144(k), a person who is not deemed to have been one of our
affiliates at any time during the 90 days before a sale, and who has
beneficially owned the restricted shares for at least two years, including the
holding period of any prior owner other than an affiliate, is entitled to sell
the shares without complying with the manner of sale, public information, volume
limitation or notice provisions of Rule 144.

                                       49
<PAGE>
RULE 701

        In general, under Rule 701, any of our employees, directors, officers,
consultants or advisors who purchase shares from us under a stock option plan or
other written agreement can resell those shares 90 days after the effective date
of this offering in reliance on Rule 144, without having to comply with certain
restrictions, including the holding period, contained in Rule 144.

LOCK-UP AGREEMENTS

        Our directors, officers and some of our existing stockholders, including
persons entitled to obtain stock upon the exercise of warrants or conversion of
our convertible notes, are subject to lock-up agreements under which they have
agreed not to transfer or dispose of, directly or indirectly, any shares of
common stock or any securities convertible into or exercisable or exchangeable
for shares of common stock, for a period of 180 days after the date of this
prospectus, subject to some exceptions. Transfers or dispositions can be made
sooner with the prior written consent of Chase Securities Inc. or its
successors.

REGISTRATION RIGHTS AND STOCK PLANS

        Some of our existing stockholders have the right to require us to
register under the Securities Act up to 2,300,000 shares of their common stock
at any time. Any stockholder who requests registration will be subject to the
lock-up agreements described above. Once we register these shares, they can be
freely sold in the public market, subject to these lock-up agreements.

        Immediately after this offering, we intend to file a registration
statement under the Securities Act covering 6,000,000 shares of our common stock
issuable upon the exercise of stock options under our 1997 Employee Stock Option
Plan. This registration statement is expected to be filed and become effective
as soon as practicable after the completion of this offering. As of the date of
this prospectus, options to purchase 3,724,250 shares of common stock were
issued and outstanding, 2,089,150 of which are currently vested and exercisable.
As a result, shares registered under those registration statements will, subject
to vesting provisions and Rule 144 volume limitations applicable to our
affiliates, be available for sale in the open market after the expiration of any
applicable lock-up agreement.

                                       50
<PAGE>
              U.S. FEDERAL TAX CONSIDERATIONS FOR NON-U.S. HOLDERS

        The following is a general discussion of the principal U.S. federal
income and estate tax consequences of the ownership and disposition of common
shares by a beneficial owner that is a non-U.S. holder. As used in this
prospectus, a non-U.S. holder is defined as a holder that for U.S. federal
income tax purposes is an individual or entity other than:

        - a citizen or individual resident of the United States;

        - a corporation or partnership created or organized in or under the laws
          of the United States or of any political subdivision thereof, other
          than a partnership treated as foreign under U.S. Treasury regulations;

        - an estate the income of which is subject to U.S. federal income
          taxation regardless of its source; or

        - a trust if a U.S. court is able to exercise primary supervision over
          the administration of the trust and one or more U.S. persons have the
          authority to control all substantial decisions of the trust.

        This discussion does not address all aspects of U.S. federal income and
estate taxes that:

        - may be relevant to non-U.S. holders in light of their personal
          circumstances, including the fact that in the case of a non-U.S.
          holder that is a partnership, the U.S. tax consequences of holding and
          disposing of common shares may be affected by determinations made at
          the partner level, or

        - may be relevant to non-U.S. holders which may be subject to special
          treatment under U.S. federal income tax laws such as insurance
          companies, tax-exempt organizations, financial institutions, dealers
          in securities and holders of securities held as part of a "straddle,"
          "hedge" or "conversion transaction."

        This discussion also does not address any tax consequences arising under
the laws of any state, local or foreign jurisdiction. Furthermore, this
discussion is based on provisions of the Internal Revenue Code of 1986, as
amended, existing and proposed regulations promulgated thereunder and
administrative and judicial interpretations thereof, all as of the date hereof,
and all of which are subject to change, possibly with retroactive effect. The
following summary is included herein for general information. ACCORDINGLY,
INVESTORS ARE URGED TO CONSULT THEIR TAX ADVISORS REGARDING THE U.S. FEDERAL,
STATE, LOCAL AND NON-U.S. INCOME AND OTHER TAX CONSEQUENCES OF ACQUIRING,
HOLDING AND DISPOSING OF COMMON SHARES.

        For purposes of this discussion, dividends and gain on the sale,
exchange or other disposition of common stock will be considered to be "U.S.
trade or business income" if the income or gain is:

(1) effectively connected with a United States trade or business, or

(2) if a treaty applies, attributable to a permanent establishment (or, in the
    case of an individual, a fixed base) in the United States.

DIVIDENDS

        We do not anticipate paying cash dividends on our common shares in the
foreseeable future. In the event, however, that dividends are paid on our common
shares, dividends paid to a non-U.S. holder of common shares generally will be
subject to withholding of U.S. federal income tax at a 30% rate, or such lower
rate as may be provided by an applicable income tax treaty. Non-U.S. holders
should consult their tax advisors regarding their entitlement to benefits under
a relevant income tax treaty.

        Dividends that are U.S. trade or business income are generally subject
to U.S. federal income tax on a net income basis at regular graduated rates, but
are not generally subject to the 30% withholding tax

                                       51
<PAGE>
if the non-U.S. holder provides a Form 4224 (or successor Form W-8ECI) to the
payor. These forms under U.S. Treasury regulations generally require the
non-U.S. holder to provide a U.S. taxpayer identification number. Any such U.S.
trade or business income received by a non-U.S. holder that is a corporation may
also be subject to an additional "branch profits tax" at a 30% rate or such
lower rate as may be specified by an applicable income tax treaty.

        Under currently applicable U.S. Treasury regulations, dividends paid to
an address in a foreign country are presumed, absent actual knowledge to the
contrary, to be paid to a resident of such country for purposes of the
withholding discussed above and for purposes of determining the applicability of
a tax treaty rate. Under U.S. Treasury regulations generally effective for
payments made after December 31, 2000; however, a non-U.S. holder of our common
shares who wishes to claim the benefit of an applicable treaty rate generally
will need to satisfy applicable certification requirements, including filing a
Form W-8BEN or Form W-8IMY and providing a document issued by foreign
governmental authorities as proof of residence in a foreign country. In
addition, under these regulations, in the case of our common shares held by a
foreign partnership or other pass-through entity, the certification requirement
will generally be applied to the partners of the partnership and the partnership
will be required to provide specified information, including filing a
Form W-8IMY. The regulations generally effective for payments made after
December 31, 2000 also provide look-through rules for tiered partnerships.
Further, the Internal Revenue Service intends to issue regulations under which a
foreign trustee or foreign executor of a U.S. or foreign trust or estate,
depending on the circumstances, will be required to furnish the appropriate
withholding certificate on behalf of the beneficiaries, trust or estate, as the
case may be.

        A non-U.S. holder of our common shares that is eligible for a reduced
rate of U.S. withholding tax under an income tax treaty may obtain a refund of
any excess amounts withheld by filing an appropriate claim for a refund with the
Internal Revenue Service.

        The U.S. Treasury regulations generally effective for payments made
after December 31, 2000 also provide special rules for dividend payments made to
foreign intermediaries, U.S. or foreign wholly owned entities that are
disregarded for U.S. federal income tax purposes and entities that are treated
as fiscally transparent in the United States, the applicable income tax treaty
jurisdiction, or both. In addition, income tax treaty benefits are denied to
foreigners receiving income derived through a partnership, or otherwise fiscally
transparent entity, in certain circumstances. Prospective investors should
consult with their own tax advisors concerning the effect, if any, of these new
Treasury regulations and this recent legislation on an investment in our common
shares.

GAIN ON DISPOSITION OF COMMON SHARES

        A non-U.S. holder generally will not be subject to U.S. federal income
tax in respect of gain realized on a disposition of our common shares unless:

        - the gain is U.S. trade or business income, in which case, the branch
          profits tax described above may also apply to a corporate non-U.S.
          holder;

        - the non-U.S. holder is an individual who holds our common shares as a
          capital asset within the meaning of Section 1221 of the Internal
          Revenue Code, is present in the United States for 183 or more days in
          the taxable year of the disposition and meets other requirements;

        - the non-U.S. holder is subject to tax under the provisions of the U.S.
          tax law applicable to certain United States expatriates; or

        - we are or have been a "U.S. real property holding corporation" for
          federal income tax purposes at any time during the shorter of the
          five-year period preceding such disposition or the period that the
          non-U.S. holder held our common shares.

                                       52
<PAGE>
        We believe that we have not been, are not currently, and do not
anticipate becoming, a "U.S. real property holding corporation" for U.S. federal
income tax purposes.

        If a non-U.S. holder who is an individual is subject to tax on gain
which is U.S. trade or business income, such individual generally will be taxed
on the net gain derived from a sale of common shares under regular graduated
U.S. federal income tax rates. If an individual non-U.S. holder is subject to
tax because such individual holds our common shares as a capital asset, is
present in the United States for 183 or more days in the taxable year of the
disposition and meets other requirements, such individual generally will be
subject to a flat 30% tax on the gain derived from a sale. This gain may be
offset by U.S. capital losses, notwithstanding the fact that the individual is
not considered a resident alien of the United States. Thus, individual non-U.S.
holders who have spent, or expect to spend, more than a DE MINIMIS period of
time in the United States in the taxable year in which they contemplate a sale
of common shares are urged to consult their tax advisors prior to the sale
concerning the U.S. tax consequences of such sale.

        If a non-U.S. holder that is a foreign corporation is subject to tax on
gain which is U.S. trade or business income, it generally will be taxed on its
net gain under regular graduated U.S. federal income tax rates and, in addition,
will be subject to the branch profits tax equal to 30% of its "effectively
connected earnings and profits," within the meaning of the Internal Revenue Code
for the taxable year, as adjusted for specific items, unless it qualifies for a
lower rate under an applicable tax treaty.

FEDERAL ESTATE TAX

        Common shares owned or treated as owned by an individual who is neither
a U.S. citizen nor a U.S. resident, as defined for U.S. federal estate tax
purposes, at the time of death will be included in the individual's gross estate
for U.S. federal estate tax purposes and may be subject to U.S. federal estate
tax, unless an applicable estate tax or other treaty provides otherwise.

INFORMATION REPORTING AND BACKUP WITHHOLDING TAX

        Under U.S. Treasury regulations, we must report annually to the Internal
Revenue Service and to each non-U.S. holder the amount of dividends paid to
these holders, the name and address of the recipient and the tax withheld with
respect to such dividends. Copies of the information returns reporting such
dividends and withholding may also be made available to the tax authorities in
the country in which the non-U.S. holder is a resident under the provisions of
an applicable income tax treaty or agreement.

        Currently, U.S. backup withholding, which generally is a withholding tax
imposed at the rate of 31% on payments to persons that fail to furnish specified
information under the U.S. information reporting requirements, generally will
not apply:

        - to dividends paid to non-U.S. holders that are subject to the 30%
          withholding discussed above, or that are not so subject because a tax
          treaty applies that reduces or eliminates such 30% withholding; or

        - before January 1, 2001, to dividends paid to a non-U.S. holder at an
          address outside of the United States unless the payor has actual
          knowledge that the payee is a U.S. person.

Backup withholding and information reporting generally will apply to dividends
paid to addresses inside the United States on our common shares to beneficial
owners that are not "exempt recipients" and that fail to provide identifying
information in the manner required.

        The payment of the proceeds of the disposition of our common shares by a
holder to or through the U.S. office of a broker or through a non-U.S. branch of
a U.S. broker generally will be subject to information reporting and backup
withholding at a rate of 31% unless the holder either certifies its status as a
non-U.S. holder under penalties of perjury or otherwise establishes an
exemption. The payment of the proceeds of the disposition by a non-U.S. holder
of common shares to or through a non-U.S. office of a

                                       53
<PAGE>
non-U.S. broker will not be subject to backup withholding or information
reporting unless the non-U.S. broker has particular types of U.S. relationships.
In the case of the payment of proceeds from the disposition of our common shares
effected by a foreign office of a broker that is a U.S. person or a U.S. related
person, existing regulations require information reporting on the payment unless
the broker maintains documentary evidence that the holder is a non-U.S. holder
and that certain conditions are met. For this purpose, a U.S. related person is
defined as:

        - a "controlled foreign corporation" for U.S. federal income tax
          purposes; or

        - a foreign person 50% or more of whose gross income from all sources
          for the three-year period ending with the close of its taxable year
          preceding the payment, or for such part of the period that the broker
          has been in existence, is derived from activities that are effectively
          connected with the conduct of a U.S. trade or business.

        The U.S. Treasury regulations generally effective for payments made
after December 31, 2000 alter the foregoing rules. Among other things, such
regulations provide presumptions under which a non-U.S. holder is subject to
backup withholding at the rate of 31% and information reporting unless we
receive certification in the form of either Form W-8BEN or Form W-8IMY from the
holder of non-U.S. status. Depending on the circumstances, this certification
will need to be provided:

        - directly by the non-U.S. holder;

        - in the case of a non-U.S. holder that is treated as a partnership,
          trust or estate, or by the partners or beneficiaries of such entity;
          or

        - by qualified financial institutions or other qualified entities on
          behalf of the non-U.S. holder.

        Backup withholding is not an additional tax. Any amounts withheld under
the backup withholding rules from a payment to a non-U.S. holder will be
refunded, or credited against the holder's U.S. federal income tax liability, if
any, provided that the required information is furnished to the Internal Revenue
Service.

                                       54
<PAGE>
                                  UNDERWRITING

        Subject to the terms and conditions contained in an underwriting
agreement dated            , 2000, the underwriters named below, through their
representatives, Chase Securities Inc., Bear, Stearns & Co. Inc. and Dain
Rauscher Incorporated have severally agreed to purchase from us the respective
number of shares of common stock set forth opposite their names below.

<TABLE>
<CAPTION>
UNDERWRITERS                                               NUMBER OF SHARES
- ------------                                               ----------------
<S>                                                        <C>
Chase Securities Inc.
Bear, Stearns & Co. Inc.
Dain Rauscher Incorporated

                                                              ---------
    Total................................................     4,000,000
                                                              =========
</TABLE>

        The underwriting agreement provides that the obligations of the
underwriters are subject to certain conditions, including the absence of any
material adverse change in our business and the receipt of certain certificates,
opinions and letters from us, our counsel and the independent auditors. The
underwriters are obligated to purchase all shares of common stock offered by us
(other than those shares covered by the over-allotment option described below)
if they purchase any shares.

        The following table shows the per share and total underwriting discounts
and commissions to be paid to the underwriters by us. These amounts are shown
assuming both no exercise and full exercise of the underwriters' over-allotment
option to purchase additional shares.

<TABLE>
<CAPTION>
                                                   NO EXERCISE   FULL EXERCISE
                                                   -----------   -------------
<S>                                                <C>           <C>
Per Share........................................  $              $
Total............................................  $              $
</TABLE>

        We estimate that the total expenses of this offering, excluding
underwriting discounts and commissions, will be approximately $1,000,000.

        The underwriters propose to offer the shares of common stock directly to
the public at the initial public offering price set forth on the cover page of
this prospectus and to certain dealers at that price less a concession not in
excess of $   per share. The underwriters may allow and the dealers may reallow
a concession not in excess of $   per share to certain other dealers. After the
initial public offering of the shares, the offering price and other selling
terms may be changed by the underwriters. The representatives have informed us
that the underwriters do not intend to confirm discretionary sales of more than
5% of the shares of common stock offered in this offering.

                                       55
<PAGE>
        We have granted to the underwriter an option, exercisable no later than
30 days after the date of this prospectus, to purchase up to 600,000 additional
shares of common stock at the initial public offering price, less the
underwriting discount set forth on the cover page of this prospectus. To the
extent that the underwriters exercise this option, each of the underwriters will
have a firm commitment to purchase approximately the same percentage thereof
which the number of shares of common stock to be purchased by it shown in the
above table bears to the total number of shares of common stock offered hereby.
We will be obligated, pursuant to the option, to sell shares to the underwriters
to the extent the option is exercised. The underwriters may exercise this option
solely to cover over-allotments, if any, made in connection with the sale of
shares of common stock offered hereby.

        The offering of the shares is made for delivery when, as and if accepted
by the underwriters and subject to prior sale and withdrawal, cancellation or
modification of the offering without notice. The underwriters reserve the right
to reject an order for the purchase of shares in whole or in part.

        We have agreed to indemnify the underwriters against certain
liabilities, including liabilities under the Securities Act and to contribute to
payments the underwriters may be required to make in respect of these
liabilities.

        Our executive officers and directors and a majority of our stockholders
who will own in the aggregate    shares of common stock after the offering, have
agreed not to, without the prior written consent of Chase Securities Inc. or its
successors, sell, offer, contract to sell, transfer the economic risk of
ownership in, make any short sale, pledge or otherwise dispose of any shares of
common stock or any securities convertible into or exchangeable or exercisable
for shares of common stock for a period of 180 days from the date of this
prospectus, subject to some exceptions. We have agreed that we will not, without
the prior written consent of Chase Securities Inc. or its successors, sell,
offer, contract to sell, transfer the economic risk of ownership in, make any
short sale, pledge or otherwise dispose of any shares of common stock or any
securities convertible into or exchangeable or exercisable for shares of common
stock for a period of 180 days following the date of this prospectus, except
that we may issue shares upon the exercise of warrants or options granted prior
to the date hereof or pursuant to outstanding convertible notes and may grant
additional options under our stock option plan. Shares issued upon exercise of
the options that are subject to lock up agreements may not be sold for 180 days
after the closing of this offering without the prior written consent of Chase
Securities Inc. or its successors.

        At our request, the underwriters have reserved up to 5% of the total
shares of common stock offered hereby for sale in the United States at the
initial public offering price to our directors, officers, employees, business
associates and related persons. The number of shares of common stock available
for sale to the general public will be reduced by the number of reserved shares
such persons purchase. Any reserved shares which are not so purchased will be
offered by the underwriters to the general public on the same basis as the other
shares offered by this prospectus. Persons who purchase reserved shares may be
required to agree that they will not, without the prior written consent of Chase
Securities Inc. or its successors, sell, offer, contract to sell, transfer the
economic risk of ownership in, make any short sale, pledge or otherwise dispose
of any shares of common stock or any securities convertible into or exchangeable
or exercisable for shares of common stock for a period of 180 days from the date
of this prospectus.

        Prior to this offering, there has been no public market for the common
stock. The initial public offering price for the common stock will be determined
by negotiation among us and the representatives of the underwriters. Among the
factors considered in determining the initial public offering price will be
prevailing market and economic conditions, our revenues and operating results,
market valuations of other companies engaged in activities similar to ours,
estimates of our business potential and our prospects, the present state of our
business operations, our management and other factors deemed relevant.

        We have applied for quotation of the common stock on the Nasdaq National
Market under the symbol TBIO.

                                       56
<PAGE>
        In March 1999, we privately placed $12,000,000 aggregate principal
amount of our convertible subordinated notes due March, 2000. Hambrecht & Quist
LLC acted as a placement agent in connection with the transaction and was paid a
fee for its services of $530,000. Hambrecht & Quist California and some of its
employees purchased convertible subordinated notes in the aggregate principal
amount of $180,000. Hambrecht & Quist Employee Venture Fund, L.P. II purchased
convertible subordinated notes in the amount of $120,000. Hambrecht & Quist
California was the parent company of Hambrecht & Quist LLC prior to February 1,
2000. Hambrecht & Quist California is a subsidiary of The Chase Manhattan
Corporation. On February 1, 2000, Hambrecht & Quist LLC merged into Chase
Securities Inc., a wholly owned subsidiary of The Chase Manhattan Corporation.
The limited partnership interests of Hambrecht & Quist Employee Venture Fund,
L.P. II are held by employees of Hambrecht & Quist California or Chase
Securities Inc. (formerly, Hambrecht & Quist LLC), and the general partner of
this fund is H&Q Venture Management LLC, a subsidiary of Hambrecht & Quist
California. The purchases described above were made on the same terms as those
made by other investors in the private placement. At any time at or after the
consummation of this offering, each convertible note may be converted into
shares of common stock.

        Chase Securities Inc. has from time to time provided financial advisory
and consulting services to us, for which we paid a one-time fee of $550,000 in
March, 1999.

        Persons participating in this offering may over-allot or effect
transactions which stabilize, maintain or otherwise affect the market price of
the common stock at levels above those which might otherwise prevail in the open
market, including by entering stabilizing bids, effecting syndicate covering
transactions or imposing penalty bids. A stabilizing bid means the placing of
any bid or effecting of any purchase, for the purpose of pegging, fixing or
maintaining the price of the common stock. A syndicate covering transaction
means the placing of any bid on behalf of the underwriting syndicate or the
effecting of any purchase to reduce a short position created in connection with
the offering. A penalty bid means an arrangement that permits the underwriters
to reclaim a selling concession from a syndicate member in connection with the
offering when shares of common stock sold by the syndicate member are purchased
in syndicate covering transactions. Such transactions may be effected on the
Nasdaq National Market, in the over-the-counter market, or otherwise. This
stabilizing, if commenced, may be discontinued at any time.

                                 LEGAL MATTERS

        The validity of the common stock offered by this prospectus will be
passed upon for us by Kutak Rock LLP, Omaha, Nebraska. Certain legal matters in
connection with this offering will be passed upon for the underwriters by
Milbank, Tweed, Hadley & McCloy LLP, New York, New York.

                                    EXPERTS

        The financial statements included in this prospectus have been audited
by Deloitte & Touche LLP, independent auditors, as stated in their report
appearing herein, and are included in reliance upon the report of such firm
given upon their authority as experts in accounting and auditing.

                      WHERE YOU CAN FIND MORE INFORMATION

        We have filed with the Securities and Exchange Commission a registration
statement on Form S-1 under the Securities Act with respect to the shares of
common stock offered hereby. This prospectus is only a part of the registration
statement and does not contain all of the information included in the
registration statement. Further information with respect to Transgenomic, Inc.
and the common stock offered hereby can be found in the registration statement
and the exhibits and schedules thereto. Statements made in this prospectus as to
the contents of any contract, agreement or other documents are not necessarily
complete, and in each instance reference is made to the copy of such contract or
other documents filed as an exhibit to the registration statement, each such
statement being qualified in all respects by such reference. The registration
statement and the exhibits and schedules thereto may be

                                       57
<PAGE>
inspected without charge at the public reference facilities maintained by the
Commission in Room 1024, 450 Fifth Street, N.W., Washington, D.C. 20549, and at
the following regional offices of the Commission: Seven World Trade Center, Room
1400, New York, New York 10048 and Citicorp Center, 500 West Madison Street,
Suite 1400, Chicago, Illinois 60661. Copies of such materials can be obtained
from the Public Reference Section of the Commission at 450 Fifth Street, N.W.,
Washington, D.C. 20549, Room 1024, at prescribed rates. The public may obtain
information on the operation of the Public Reference Room by calling the SEC at
1-800-SEC-0330. In addition, we are required to file electronic versions of
these documents with the Commission through the Commission's Electronic Data
Gathering, Analysis, and Retrieval (EDGAR) system. The Commission maintains an
internet site at http://www.sec.gov that contains reports, proxy and information
statements and other information regarding registrants that file electronically
with the Commission. Information concerning Transgenomic, Inc. is also available
for inspection at the offices of the Nasdaq Stock Market, Reports Section, 1735
K Street, N.W., Washington, D.C. 20006.

        We intend to furnish to our stockholders annual reports containing
consolidated financial statements audited by an independent public accounting
firm and quarterly reports for the first three quarters of each fiscal year
containing unaudited consolidated financial data.

                                       58
<PAGE>
                               TRANSGENOMIC, INC.
                         INDEX TO FINANCIAL STATEMENTS

<TABLE>
<CAPTION>
                                                                PAGE
                                                              --------
<S>                                                           <C>
Consolidated Financial Statements:

  Independent Auditors' Report..............................     F-2

  Consolidated Balance Sheets...............................     F-3

  Consolidated Statements of Operations.....................     F-4

  Consolidated Statements of Stockholders' Equity
    (Deficit)...............................................     F-5

  Consolidated Statements of Cash Flows.....................     F-6

  Notes to Consolidated Financial Statements................     F-7

Unaudited Pro Forma Financial Information:

  Unaudited Pro Forma Balance Sheet.........................    F-22

  Unaudited Pro Forma Statement of Operations...............    F-23

  Notes to Unaudited Pro Forma Financial Information........    F-24
</TABLE>

                                      F-1
<PAGE>
                          INDEPENDENT AUDITORS' REPORT

Board of Directors
Transgenomic, Inc.
Omaha, Nebraska

        We have audited the accompanying consolidated balance sheets of
Transgenomic, Inc. and subsidiaries (the Company) as of December 31, 1998 and
1999 and the related consolidated statements of operations, stockholders' equity
(deficit) and cash flows for each of the three years in the period ended
December 31, 1999. These financial statements are the responsibility of the
Company's management. Our responsibility is to express an opinion on these
financial statements based on our audits.

        We conducted our audits in accordance with auditing standards generally
accepted in the United States of America. Those standards require that we plan
and perform the audit to obtain reasonable assurance about whether the financial
statements are free of material misstatement. An audit includes examining, on a
test basis, evidence supporting the amounts and disclosures in the financial
statements. An audit also includes assessing the accounting principles used and
significant estimates made by management, as well as evaluating the overall
financial statement presentation. We believe that our audits provide a
reasonable basis for our opinion.

        In our opinion, such consolidated financial statements present fairly,
in all material respects, the financial position of Transgenomic, Inc. and
subsidiaries as of December 31, 1998 and 1999, and the results of their
operations and their cash flows for each of the three years in the period ended
December 31, 1999 in conformity with accounting principles generally accepted in
the United States of America.

/s/ DELOITTE & TOUCHE LLP

Omaha, Nebraska
March 7, 2000

                                      F-2
<PAGE>
                      TRANSGENOMIC, INC. AND SUBSIDIARIES

                          CONSOLIDATED BALANCE SHEETS

                        AS OF DECEMBER 31, 1998 AND 1999

<TABLE>
<CAPTION>
                                                                 1998           1999
                                                              -----------   ------------
<S>                                                           <C>           <C>
                                         ASSETS
CURRENT ASSETS:
  Cash and cash equivalents.................................  $   187,455   $    153,336
  Accounts receivable, net..................................    4,425,419      6,199,059
  Inventories...............................................    4,183,509      6,043,025
  Prepaid expenses and other current assets.................      292,926        527,461
  Deferred income taxes.....................................      114,000             --
  Refundable income taxes...................................       34,000         96,000
                                                              -----------   ------------
    Total current assets....................................    9,237,309     13,018,881
PROPERTY AND EQUIPMENT:
  Equipment.................................................    3,272,132      4,695,785
  Furniture and fixtures....................................    1,070,569      1,567,370
                                                              -----------   ------------
                                                                4,342,701      6,263,155
  Less--accumulated depreciation............................    2,931,886      3,682,016
                                                              -----------   ------------
                                                                1,410,815      2,581,139
OTHER ASSETS................................................    4,087,940      4,363,490
                                                              -----------   ------------
                                                              $14,736,064   $ 19,963,510
                                                              ===========   ============

                     LIABILITIES AND STOCKHOLDERS' EQUITY (DEFICIT)
CURRENT LIABILITIES:
  Note payable--bank........................................  $ 3,150,000   $  4,340,000
  Current portion of notes payable--other...................      432,338        579,724
  Accounts payable..........................................    2,287,451      2,827,186
  Accrued compensation......................................      533,680        666,219
  Other accrued expenses....................................      988,950      1,111,871
                                                              -----------   ------------
    Total current liabilities...............................    7,392,419      9,525,000
NOTES PAYABLE--OTHER, LESS CURRENT MATURITIES...............      694,536        116,958
CONVERTIBLE NOTES PAYABLE...................................           --     12,421,010
COMMITMENTS AND CONTINGENCIES (NOTES H, J, L, M AND N)
STOCKHOLDERS' EQUITY (DEFICIT):
  Preferred stock, $.01 par value, 15,000,000 shares
    authorized, none outstanding............................           --             --
  Common stock, $.01 par value, 30,000,000 shares
    authorized, 13,000,000 shares issued and outstanding in
    1998 and 1999...........................................      130,000        130,000
  Additional paid-in capital................................   10,119,095     10,231,595
  Note receivable related party.............................   (1,085,931)            --
  Unearned compensation.....................................           --       (112,500)
  Accumulated deficit.......................................   (2,517,189)   (12,344,075)
  Accumulated other comprehensive income (loss).............        3,134         (4,478)
                                                              -----------   ------------
    Total stockholders' equity (deficit)....................    6,649,109     (2,099,458)
                                                              -----------   ------------
                                                              $14,736,064   $ 19,963,510
                                                              ===========   ============
</TABLE>

                SEE NOTES TO CONSOLIDATED FINANCIAL STATEMENTS.

                                      F-3
<PAGE>
                      TRANSGENOMIC, INC. AND SUBSIDIARIES

                     CONSOLIDATED STATEMENTS OF OPERATIONS

                  YEARS ENDED DECEMBER 31, 1997, 1998 AND 1999

<TABLE>
<CAPTION>
                                                                 1997          1998          1999
                                                              -----------   -----------   -----------
<S>                                                           <C>           <C>           <C>
NET SALES...................................................  $11,576,677   $18,935,440   $23,034,954
COST OF GOODS SOLD..........................................    6,335,986     9,590,663    12,090,036
                                                              -----------   -----------   -----------
    Gross profit............................................    5,240,691     9,344,777    10,944,918
OPERATING EXPENSES:
  General and administrative................................    2,444,398     2,795,199     3,771,663
  Marketing and sales.......................................    3,967,574     5,364,953     7,759,997
  Research and development..................................    2,047,057     3,159,377     6,296,859
                                                              -----------   -----------   -----------
                                                                8,459,029    11,319,529    17,828,519
                                                              -----------   -----------   -----------
LOSS FROM OPERATIONS........................................   (3,218,338)   (1,974,752)   (6,883,601)
OTHER INCOME (EXPENSE):
  Interest expense, net of interest income of $53,527,
    $59,147 and $126,215 in 1997, 1998 and 1999,
    respectively............................................     (412,755)     (516,366)   (1,198,378)
  Other--net................................................      (14,634)      (15,282)          366
                                                              -----------   -----------   -----------
                                                                 (427,389)     (531,648)   (1,198,012)
                                                              -----------   -----------   -----------
LOSS BEFORE INCOME TAXES....................................   (3,645,727)   (2,506,400)   (8,081,613)
INCOME TAX EXPENSE (BENEFIT):
  Current...................................................     (348,702)       19,993       (27,727)
  Deferred..................................................     (887,486)     (950,000)    1,773,000
                                                              -----------   -----------   -----------
                                                               (1,236,188)     (930,007)    1,745,273
                                                              -----------   -----------   -----------
NET LOSS....................................................  $(2,409,539)  $(1,576,393)  $(9,826,886)
                                                              ===========   ===========   ===========
BASIC AND DILUTED LOSS PER SHARE............................  $     (0.22)  $     (0.13)  $     (0.76)
                                                              ===========   ===========   ===========
BASIC AND DILUTED WEIGHTED AVERAGE SHARES OUTSTANDING.......   11,144,583    12,279,042    13,000,000
                                                              ===========   ===========   ===========
</TABLE>

                SEE NOTES TO CONSOLIDATED FINANCIAL STATEMENTS.

                                      F-4
<PAGE>
                      TRANSGENOMIC, INC. AND SUBSIDIARIES
           CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (DEFICIT)
                  YEARS ENDED DECEMBER 31, 1997, 1998 AND 1999
<TABLE>
<CAPTION>

                                                                                                            RETAINED
                                                              ADDITIONAL                                    EARNINGS
                                      COMMON    PREFERRED      PAID-IN          NOTE         UNEARNED     (ACCUMULATED
                                      STOCK       STOCK        CAPITAL       RECEIVABLE    COMPENSATION     DEFICIT)
                                     --------   ---------   --------------   -----------   ------------   ------------
<S>                                  <C>        <C>         <C>              <C>           <C>            <C>
BALANCE, JANUARY 1, 1997...........  $    110   $ 41,000    $    1,242,940   $  (650,782)   $      --     $  1,479,904
  Net loss.........................        --         --                --            --           --       (2,409,539)
  Other comprehensive income
    (loss):
    Foreign currency translation
      adjustment...................        --         --                --            --           --               --
      Comprehensive income
        (loss).....................        --         --                --            --           --               --
  Note receivable from related
    party..........................        --         --                --      (369,062)          --               --
  Preferred stock dividends........        --         --                --            --           --          (11,161)
  Redeem 410 shares of preferred
    stock..........................        --    (41,000)               --            --           --               --
  1,000 to 1 stock exchange........   109,890         --          (109,890)           --           --               --
  Sale of 351,500 common shares....     3,515         --         1,620,354            --           --               --
  Issuance of warrants to purchase
    300,000 common shares..........        --         --            82,117            --           --               --
                                     --------   --------    --------------   -----------    ---------     ------------
BALANCE, DECEMBER 31, 1997.........   113,515         --         2,835,521    (1,019,844)          --         (940,796)
  Net loss.........................        --         --                --            --           --       (1,576,393)
  Other comprehensive income
    (loss):
    Foreign currency translation
      adjustment...................        --         --                --            --           --               --
      Comprehensive income
        (loss).....................        --         --                --            --           --               --
  Note receivable from related
    party..........................        --         --                --       (66,087)          --               --
  Sale of 1,648,500 common
    shares.........................    16,485         --         7,283,574            --           --               --
                                     --------   --------    --------------   -----------    ---------     ------------
BALANCE, DECEMBER 31, 1998.........   130,000         --        10,119,095    (1,085,931)          --       (2,517,189)
  Net loss.........................        --         --                --            --           --       (9,826,886)
  Other comprehensive income
    (loss):
    Foreign currency translation
      adjustment...................        --         --                --            --           --               --
      Comprehensive income
        (loss).....................        --         --                --            --           --               --
  Issuance of 22,500 stock
    options........................        --         --           112,500            --     (112,500)              --
  Note receivable from related
    party..........................        --         --                --     1,085,931           --               --
                                     --------   --------    --------------   -----------    ---------     ------------
BALANCE, DECEMBER 31, 1999.........  $130,000   $     --    $   10,231,595   $        --    $(112,500)    $(12,344,075)
                                     ========   ========    ==============   ===========    =========     ============

<CAPTION>
                                      ACCUMULATED
                                         OTHER
                                     COMPREHENSIVE
                                        INCOME
                                        (LOSS)          TOTAL
                                     -------------   -----------
<S>                                  <C>             <C>
BALANCE, JANUARY 1, 1997...........   $       768    $ 2,113,940
  Net loss.........................    (2,409,539)    (2,409,539)
  Other comprehensive income
    (loss):
    Foreign currency translation
      adjustment...................         1,348          1,348
                                      -----------
      Comprehensive income
        (loss).....................    (2,408,191)
                                      -----------
  Note receivable from related
    party..........................            --       (369,062)
  Preferred stock dividends........            --        (11,161)
  Redeem 410 shares of preferred
    stock..........................            --        (41,000)
  1,000 to 1 stock exchange........            --             --
  Sale of 351,500 common shares....            --      1,623,869
  Issuance of warrants to purchase
    300,000 common shares..........            --         82,117
                                      -----------    -----------
BALANCE, DECEMBER 31, 1997.........         2,116        990,512
  Net loss.........................    (1,576,393)    (1,576,393)
  Other comprehensive income
    (loss):
    Foreign currency translation
      adjustment...................         1,018          1,018
                                      -----------
      Comprehensive income
        (loss).....................    (1,575,375)            --
                                      -----------
  Note receivable from related
    party..........................            --        (66,087)
  Sale of 1,648,500 common
    shares.........................            --      7,300,059
                                      -----------    -----------
BALANCE, DECEMBER 31, 1998.........         3,134      6,649,109
  Net loss.........................    (9,826,886)    (9,826,886)
  Other comprehensive income
    (loss):
    Foreign currency translation
      adjustment...................        (7,612)        (7,612)
                                      -----------
      Comprehensive income
        (loss).....................    (9,834,498)            --
                                      -----------
  Issuance of 22,500 stock
    options........................            --             --
  Note receivable from related
    party..........................            --      1,085,931
                                      -----------    -----------
BALANCE, DECEMBER 31, 1999.........   $    (4,478)   $(2,099,458)
                                      ===========    ===========
</TABLE>

                SEE NOTES TO CONSOLIDATED FINANCIAL STATEMENTS.

                                      F-5
<PAGE>
                               TRANSGENOMIC INC.
                                AND SUBSIDIARIES

                     CONSOLIDATED STATEMENTS OF CASH FLOWS
                  YEARS ENDED DECEMBER 31, 1997, 1998 AND 1999

<TABLE>
<CAPTION>
                                                                 1997          1998          1999
                                                              -----------   -----------   -----------
<S>                                                           <C>           <C>           <C>
CASH FLOWS FROM OPERATING ACTIVITIES:
  Net loss..................................................  $(2,409,539)  $(1,576,393)  $(9,826,886)
  Adjustments to reconcile net loss to net cash flows from
    operating activities:
    Depreciation and amortization...........................      918,214       798,708     1,364,246
    Deferred income taxes...................................     (887,486)     (950,000)    1,773,000
    Gain on sale of assets..................................      (72,250)       (8,411)      (16,105)
    Accrued interest and redemption premium.................           --            --       858,665
    Amortization of deferred financing costs................           --            --       149,960
    Changes in operating assets and liabilities, net of
      acquisitions:
      Accounts receivable...................................      318,646    (2,029,247)   (1,635,316)
      Inventories...........................................     (174,192)   (1,717,595)   (1,775,273)
      Prepaid expenses and other current liabilities........       52,704       (81,250)     (233,686)
      Refundable income taxes...............................      (54,000)      388,000       (62,000)
      Accounts payable......................................     (342,096)    1,392,087       481,068
      Accrued expenses......................................       39,600       340,178       178,793
                                                              -----------   -----------   -----------
        Net cash flows from operating activities............   (2,610,399)   (3,443,923)   (8,743,534)

CASH FLOWS FROM INVESTING ACTIVITIES:
  Purchase of property and equipment........................     (486,190)     (682,674)   (1,828,047)
  Proceeds from asset sales.................................      153,305        10,000        21,425
  Increase in other assets..................................     (152,373)     (813,405)   (1,461,250)
  Purchase of business, net of cash acquired................           --            --      (187,294)
  Note receivable...........................................       15,560        22,946            --
                                                              -----------   -----------   -----------
        Net cash flows from investing activities............     (469,698)   (1,463,133)   (3,455,166)

CASH FLOWS FROM FINANCING ACTIVITIES:
  Issuance of common stock and common stock warrants........    1,705,986     7,300,059            --
  Net change in note payable--bank..........................      750,000      (800,000)    1,190,000
  Proceeds from notes payable--other........................    1,467,918       100,000            --
  Payments on notes payable--other..........................     (361,343)   (1,964,555)     (430,192)
  Proceeds from convertible notes payable...................           --            --    12,000,000
  Deferred financing costs..................................           --            --      (587,615)
  Increase in related party receivables.....................     (369,062)      (66,087)           --
                                                              -----------   -----------   -----------
        Net cash flows from financing activities............    3,193,499     4,569,417    12,172,193

EFFECT OF FOREIGN CURRENCY EXCHANGE RATE CHANGES ON CASH....        1,348         1,018        (7,612)
                                                              -----------   -----------   -----------
NET CHANGE IN CASH AND CASH EQUIVALENTS.....................      114,750      (336,621)      (34,119)
CASH AND CASH EQUIVALENTS AT BEGINNING OF YEAR..............      409,326       524,076       187,455
                                                              -----------   -----------   -----------
CASH AND CASH EQUIVALENTS AT END OF YEAR....................  $   524,076   $   187,455   $   153,336
                                                              ===========   ===========   ===========
SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION:
  Cash paid for interest....................................  $   424,501   $   472,579   $   318,856
                                                              ===========   ===========   ===========
  Cash paid for taxes.......................................  $    17,026   $    30,120   $    37,630
                                                              ===========   ===========   ===========
</TABLE>

                SEE NOTES TO CONSOLIDATED FINANCIAL STATEMENTS.

                                      F-6
<PAGE>
                      TRANSGENOMIC, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

                  YEARS ENDED DECEMBER 31, 1997, 1998 AND 1999

A. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

    BUSINESS DESCRIPTION.

        Transgenomic, Inc., a Delaware corporation, and its subsidiaries (the
"Company") provide innovative research tools to the life sciences industry.
These tools enable researchers to discover and understand variation in the human
genetic code, or genome, in order to accelerate and improve drug development and
diagnostics. The Company also manufactures and designs sample preparation and
monitoring instruments, which are primarily used with various types of optical
and mass spectrometers to analyze the chemical makeup of samples. The Company
markets and sells these platforms primarily throughout North America, Europe and
the Pacific Rim.

    PRINCIPLES OF CONSOLIDATION.

        The consolidated financial statements include the accounts of
Transgenomic, Inc. and its wholly-owned subsidiaries Transgenomic, Ltd. (fka
CETAC Technologies, Ltd.), which provides sales and customer support outside the
United States and Transgenomic St. Thomas, Inc., which is organized as a foreign
sales corporation. All material intercompany balances and transactions have been
eliminated. On July 1, 1997 the Company merged with CETAC Holding Company, Inc.
in a 1000 to 1 stock exchange. Before and after the merger, the companies had
identical ownership structures. Accordingly, this transaction was between
companies under common control and was accounted for similar to a pooling of
interests. The Company had no assets, liabilities or operations prior to its
merger with CETAC Holding Company, Inc.

    SALES AND DISTRIBUTION STRATEGY.

        The Company sells and distributes its product lines in three major ways:

    1)  DIRECT--The Company serves the United States market through direct sales
       efforts from the Company headquarters in Omaha. The Company has direct
       salespeople strategically located to cover all sections of the United
       States and Europe.

    2)  DISTRIBUTORS--The Company has contracted with distributors in its major
       European and Pacific Rim markets for all products.

    3)  ORIGINAL EQUIPMENT MANUFACTURERS (OEM)--The Company distributes its
       sample preparation and monitoring instruments through major ICP
       (intra-coupled plasma) spectrometer manufacturers and their authorized
       representatives.

        The Company has sales offices in the United States, United Kingdom and
Japan. These offices function mainly as service and support centers and also as
sales resources for OEM and distributor customers in Europe.

    CASH AND CASH EQUIVALENTS.

        For purposes of reporting cash flows, cash and cash equivalents include
cash and temporary investments with maturities at acquisition of three months or
less.

                                      F-7
<PAGE>
                      TRANSGENOMIC, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

            YEARS ENDED DECEMBER 31, 1997, 1998 AND 1999 (CONTINUED)

A. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)
    ACCOUNTS RECEIVABLE.

        Accounts receivable are shown net of allowance for doubtful accounts of
approximately $561,645 and $160,593 in 1998 and 1999, respectively.

    INVENTORIES.

        Inventories are stated at the lower of cost (first-in, first-out method)
or market. The Company has certain finished goods inventory it provides as
demonstration units to potential customers for evaluation, as well as to certain
universities and original equipment manufacturers for testing and demonstration.
These demonstration units are included in inventory at cost. If the instrument
is not purchased by the customer or institution, it is retrieved, and, if
necessary, reconditioned for sale. If these instruments remain in demonstration
mode and/or exhibit wear, they are removed from inventory, capitalized into
property and depreciated.

    PROPERTY AND EQUIPMENT.

        Property and equipment are carried at cost. Depreciation and
amortization are computed by the straight-line and accelerated methods over the
estimated useful lives of the related assets as follows:

<TABLE>
<S>                                                           <C>
Furniture and fixtures......................................  5 to 7 years
Production equipment........................................  5 to 7 years
Computer equipment..........................................       5 years
Research and development equipment..........................  3 to 5 years
</TABLE>

    GOODWILL.

        Goodwill arising from the excess of cost over the fair value of net
assets at dates of acquisition is being amortized using the straight-line method
over 15 years.

    IMPAIRMENT OF LONG-LIVED ASSETS.

        The Company assesses the recoverability of long-lived assets held for
use, including certain intangible assets and goodwill, whenever events or
changes in circumstances indicate that the carrying amount of an asset may not
be recoverable. In such cases, if the sum of the expected cash flows
(undiscounted and without interest) resulting from the use of the asset are less
than the carrying amount, an impairment loss is recognized based on the
difference between the carrying amount and the fair value of the assets. No
impairment loss has been recognized to date.

    OTHER ASSETS.

        Other assets include patents, capitalized software and intellectual
property. The Company capitalizes the external and in-house legal costs and
filing fees associated with obtaining patents on its new discoveries and
amortizes these costs using the straight-line method over the shorter of the
legal life of the patent or its economic life, generally 17 years, beginning in
the first full year of production utilizing the new discovery after the patent
is awarded.

                                      F-8
<PAGE>
                      TRANSGENOMIC, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

            YEARS ENDED DECEMBER 31, 1997, 1998 AND 1999 (CONTINUED)

A. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)
        The Company develops software as an integral component of their
instruments. After functional design is completed and economic viability is
determined, the Company capitalizes the development cost. The software is
amortized over the estimated life of the product, generally three years.
Intellectual property is amortized over its estimated useful life of between 5
and 10 years.

    DEFERRED FINANCING COSTS.

        Deferred financing costs are amortized over the term of the related
financing using the effective interest method.

    STOCK BASED COMPENSATION.

        The Company accounts for its stock-based compensation under the
provisions of Accounting Principles Board Opinion No. 25, ACCOUNTING FOR STOCK
ISSUED TO EMPLOYEES, which utilizes the intrinsic value method.

    UNEARNED COMPENSATION.

        Unearned compensation represents the unamortized difference between the
option exercise price and the deemed fair market value of the Company's common
stock at the option grant date, for options issued under the Company's Stock
Option Plan (Note L). The unearned compensation is charged to operations over
the vesting period of the respective options.

    INCOME TAXES.

        The liability method is used to measure deferred tax assets and
liabilities based on temporary differences between financial and taxable income
existing at each balance sheet date using enacted tax rates.

    REVENUE RECOGNITION.

        Sales of products and services are recorded based on shipment of product
or performance of services.

    RESEARCH AND DEVELOPMENT.

        Research and development costs are charged to expense when incurred.

    TRANSLATION OF FOREIGN CURRENCY.

        Financial statements of subsidiaries outside the U.S. are measured using
the local currency as the functional currency. The adjustments to translate
those amounts into U.S. dollars are accumulated in a separate account in
stockholders' equity and are included in other comprehensive income. Foreign
currency transaction gains or losses resulting from changes in currency exchange
rates are included in the determination of net income. For the periods
presented, foreign currency transaction adjustments were not significant.

                                      F-9
<PAGE>
                      TRANSGENOMIC, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

            YEARS ENDED DECEMBER 31, 1997, 1998 AND 1999 (CONTINUED)

A. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)
    COMPREHENSIVE INCOME.

        Comprehensive income for all periods presented consists of net income
and foreign currency translation adjustments. The Company deems its foreign
investments to be permanent in nature and does not provide for taxes on currency
translation adjustments arising from converting its investments in a foreign
currency to U.S. dollars. There were no reclassification adjustments to be
reported in the periods presented.

    FAIR VALUE OF FINANCIAL INSTRUMENTS.

        Unless otherwise specified, the Company believes the book value of
financial instruments approximates fair value.

    EARNINGS PER SHARE.

        Basic earnings per share are calculated based on the weighted-average
number of common shares outstanding during each period. Diluted earnings per
share include shares issuable upon exercise of outstanding stock options and
warrants, where dilutive. Potentially dilutive securities have been excluded
from the computation of diluted earnings per share as they have an antidilutive
effect due to the Company's net loss. Weighted-average shares outstanding
reflects the 1,000 to 1 stock exchange which occurred on July 1, 1997, in
connection with the merger of Transgenomic, Inc. and CETAC Holding Company, as
if such exchange occurred at the beginning of the earliest period presented.

    ACCOUNTING PRONOUNCEMENTS.

        In June 1998, the Financial Accounting Standards Board issued Statement
of Financial Accounting Standards No. 133, ACCOUNTING FOR DERIVATIVE INSTRUMENTS
AND HEDGING ACTIVITIES, (SFAS No. 133). This statement, which is effective for
fiscal years beginning after June 15, 2000, requires the recognition of all
derivative financial instruments as either assets or liabilities in the
statement of financial position and measurement of those instruments at fair
value. Management is in the process of determining the effect, if any, SFAS No.
133 will have on the Company's financial statements.

        In 1999, the Company adopted Statement of Position 98-1, ACCOUNTING FOR
THE COSTS OF COMPUTER SOFTWARE DEVELOPED OR OBTAINED FOR INTERNAL USE, (SOP
98-1) which, on a prospective basis, revised the accounting for software
development costs. SOP 98-1 requires the capitalization of certain costs related
to internal use software once certain criteria have been met. The adoption of
this statement did not have a material impact on the Company's financial
statements.

    USE OF ESTIMATES.

        The preparation of consolidated financial statements in conformity with
generally accepted accounting principles requires management to make estimates
and assumptions that affect the reported amounts of assets and liabilities and
disclosure of contingent assets and liabilities at the date of the financial
statements and the reported amounts of revenues and expenses during the
reporting period. Actual results could differ from those estimates.

                                      F-10
<PAGE>
                      TRANSGENOMIC, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

            YEARS ENDED DECEMBER 31, 1997, 1998 AND 1999 (CONTINUED)

A. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)
    RECLASSIFICATIONS.

        Certain reclassifications have been made to the 1997 and 1998 financial
statements to conform with the 1999 presentation.

B. ACQUISITION

        On January 26, 1999, the Company, through its UK subsidiary, acquired
substantially all of the assets of Kramel Biotech International, Limited
(Kramel) for approximately $187,000 in cash and the assumption of certain
liabilities of Kramel, and entered into employment agreements with the two
principals. Kramel manufactures laboratory consumables used in the field of
molecular biology. The acquisition was accounted for as a purchase and resulted
in goodwill of approximately $66,000. All identifiable assets acquired and
liabilities assumed were allocated a portion of the cost, equal to their fair
values.

C. INVENTORIES

        At December 31, 1998 and 1999 inventories consist of the following:

<TABLE>
<CAPTION>
                                                          1998         1999
                                                       ----------   ----------
<S>                                                    <C>          <C>
Finished goods.......................................  $1,888,173   $3,256,067
Raw materials and work in process....................   2,295,336    2,786,958
                                                       ----------   ----------
                                                       $4,183,509   $6,043,025
                                                       ==========   ==========
</TABLE>

        Within the total inventory above, the Company has demonstration
inventory of approximately $1,631,000 and $3,098,851 for 1998 and 1999,
respectively.

D. OTHER ASSETS

        At December 31, 1998 and 1999, other assets consist of the following:

<TABLE>
<CAPTION>
                                                 1998                                    1999
                                 -------------------------------------   -------------------------------------
                                              ACCUMULATED    NET BOOK                 ACCUMULATED    NET BOOK
                                    COST        RESERVE       VALUE         COST        RESERVE       VALUE
                                 ----------   -----------   ----------   ----------   -----------   ----------
<S>                              <C>          <C>           <C>          <C>          <C>           <C>
Deferred income taxes..........  $1,839,000     $     --    $1,839,000   $  180,000   $       --    $  180,000
Goodwill.......................     843,446      235,435       608,011      909,492      306,463       603,029
Intellectual property..........     534,852      160,455       374,397    2,534,852      447,273     2,087,579
Patents........................     815,934        8,010       807,924    1,076,384       21,107     1,055,277
Software.......................     369,678      118,558       251,120      503,730      227,079       276,651
Other..........................     309,103      101,615       207,488      160,954           --       160,954
                                 ----------     --------    ----------   ----------   ----------    ----------
    Total......................  $4,712,013     $624,073    $4,087,940   $5,365,412   $1,001,922    $4,363,490
                                 ==========     ========    ==========   ==========   ==========    ==========
</TABLE>

                                      F-11
<PAGE>
                      TRANSGENOMIC, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

            YEARS ENDED DECEMBER 31, 1997, 1998 AND 1999 (CONTINUED)

E. NOTE PAYABLE--BANK

        At December 31, 1998 and 1999, note payable--bank consisted of
borrowings in the amounts of $3,150,000 and $4,340,000, respectively, against a
revolving line of credit of $5,000,000. The note carries an interest rate equal
to the national prime. The interest is payable monthly. The interest rate at
December 31, 1998 and 1999 was 7.75% and 8.50%, respectively. The line matures
July 31, 2000. Substantially all of the Company's assets and certain life
insurance policies are pledged as collateral on this note payable. The loan
contains certain restrictive covenants, including a prohibition on the payment
of dividends, the purchase of its stock, and the redemption of stock options and
warrants, among other things, without the written agreement of the lender. As of
December 31, 1999, the Company was not in compliance with these covenants.
However, a waiver was obtained from the bank as of December 31, 1999.

F. NOTES PAYABLE--OTHER

        Notes payable--other at December 31, 1998 and 1999 consists of the
following:

<TABLE>
<CAPTION>
                                                            1998        1999
                                                         ----------   --------
<S>                                                      <C>          <C>
Installment note payable to a bank maturing on December
  1, 2000; payable in monthly installments of $15,618,
  which includes interest of 9.0%; collateralized by
  all equipment and furnishings........................  $  342,194   $179,711
Installment note payable to a bank maturing on August
  13, 2001; payable in monthly installments of $15,123
  which includes interest of 9.0%; collateralized by
  all equipment and furnishings........................     429,516    280,436
Note payable to a living trust, payable in monthly
  installments of $11,000 including interest at 5.33%
  per year, due March 1, 2000 secured by certain assets
  of the Company's California division.................     355,164    236,535
                                                         ----------   --------
Total notes payable--other.............................   1,126,874    696,682
Less current portion...................................     432,338    579,724
                                                         ----------   --------
Notes payable--other excluding current portion.........  $  694,536   $116,958
                                                         ==========   ========
</TABLE>

        Aggregate maturities of notes payable--other at December 31, 1999
consist of the following:

<TABLE>
<S>                                                           <C>
YEAR ENDING DECEMBER 31,
2000........................................................  $579,724
2001........................................................   116,958
                                                              --------
                                                              $696,682
                                                              ========
</TABLE>

        In connection with certain installment notes payable to a bank, the
Company must comply with certain restrictive covenants. As of December 31, 1999,
the Company was not in compliance with these covenants. However, a waiver was
obtained from the bank as of December 31, 1999.

                                      F-12
<PAGE>
                      TRANSGENOMIC, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

            YEARS ENDED DECEMBER 31, 1997, 1998 AND 1999 (CONTINUED)

G. CONVERTIBLE NOTES PAYABLE

        On March 23, 1999, the Company received approximately $11.4 million of
net proceeds from the placement of $12 million aggregate principal amount 6%
convertible notes due March 25, 2002. Interest on the notes compounds at 6% per
annum until maturity or a Designated Offering (as defined) ("Offering") and
either will be payable in cash upon repayment of the note at or after the
maturity date, or if elected upon the completion of an Offering all accrued and
unpaid interest shall be converted into shares of common stock. The interest
after an Offering shall be reduced to 3.6%, and shall become due for the
remainder of the term through the maturity date at the time of an Offering.

        The holder shall have the right to convert the principal amounts due
under these notes into shares of the Company's common stock. If the Company
completes an Offering prior to September 25, 2000, the conversion price shall be
either the lesser of $5.00 per share or 50% of the per share offering price. If
the Offering is completed between September 25, 2000 and the maturity date, the
conversion price shall be the lesser of $5.00 per share, or between 35% and 50%
of the per share offering price to the public, calculated on a declining
straight-line basis, through the day on which an offering is completed. If an
Offering is not completed before the maturity date, the holder may elect to
convert at $5.00 per share but the price will be adjusted to 35% of the Offering
price if less than $5.00 per share, and additional shares, if any, will be
issued to reduce the conversion price to such lesser amount.

        If prior to consummation of an Offering, the Company enters into a
merger, consolidation, the sale of substantially all of its assets, change of
control, or the dissolution of the Company or other event causing final
liquidation, the holders of the notes shall have the right to elect to either
receive payment in full of all principal of the notes and accrued interest
earned through date of payment, or convert all outstanding principal and unpaid
interest on the notes into common stock. The holders will be entitled to receive
the greater of the number of shares derived by dividing the balance due by $5.00
per share, or the number of shares having an aggregate value equal to 200% of
the outstanding unpaid principal, plus all accrued interest.

        If the note holders elect not to convert the notes to stock at maturity,
the Company will be required to repay all principal amounts, all accrued and
unpaid interest, if any, and a redemption premium equal to 10% of the face value
of the notes. The Company can require conversion after an Offering provided
specific closing prices are achieved for twenty consecutive trading days.

        The notes contain numerous covenants with which the Company is in
compliance.

        At December 1999, the convertible notes payable balance is comprised of
the following:

<TABLE>
<S>                                                           <C>
Principal...................................................  $12,000,000
Accrued interest and redemption premium.....................      858,665
                                                              -----------
                                                               12,858,665

Deferred financing costs (net of accumulated amortization of
  $149,960).................................................     (437,655)
                                                              -----------
                                                              $12,421,010
                                                              ===========
</TABLE>

                                      F-13
<PAGE>
                      TRANSGENOMIC, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

            YEARS ENDED DECEMBER 31, 1997, 1998 AND 1999 (CONTINUED)

H. LEASE COMMITMENTS

        The Company leases certain equipment, vehicles and operating facilities.
The Company's leases related to its operating facilities currently expire on
various dates ranging from 1999 through 2006. However, one lease allows for
cancellation at either 36 or 48 months upon 60 days advanced written notice. At
December 31, 1999, the future minimum lease payments required under
noncancellable lease provisions are approximately $830,000 in 2000; $591,000 in
2001; $304,000 in 2002; $148,000 in 2003; $128,000 in 2004; and a total of
approximately $188,000 in rental payments for the years 2005 through 2006.

        Net rental expense related to all operating leases for the years ended
December 31, 1997, 1998 and 1999 was approximately $441,000, $655,000 and
$984,000, respectively.

I. INCOME TAXES

        The Company's provision for income taxes for the years ended December 31
differs from the amounts determined by applying the statutory Federal income tax
rate to income before income taxes for the following reasons:

<TABLE>
<CAPTION>
                                                               1997         1998         1999
                                                            -----------   ---------   -----------
<S>                                                         <C>           <C>         <C>
Benefit at Federal Rate...................................  $(1,239,547)  $(852,176)  $(2,747,748)

Increase (decrease) resulting from:
  State income taxes--net of federal benefit..............      (45,004)    (85,805)      (62,520)
  Intangible amortization.................................       46,804      39,020        42,925
  Research and development tax credit.....................      (15,319)    (23,534)      (54,231)
  Meals and entertainment.................................       16,999      27,037        38,687
  Other--net..............................................         (121)    (34,549)       37,160
  Valuation allowance.....................................           --          --     4,491,000
                                                            -----------   ---------   -----------
Total income tax expense (benefit)........................  $(1,236,188)  $(930,007)  $ 1,745,273
                                                            ===========   =========   ===========
</TABLE>

        The Company's deferred income tax asset at December 31, 1998 and 1999 is
comprised of the following temporary differences:

<TABLE>
<CAPTION>
                                                          1998         1999
                                                       ----------   ----------
<S>                                                    <C>          <C>
Net operating loss carryforward......................  $1,497,000   $4,289,000
Allowance for doubtful accounts......................     221,000       60,000
Fixed asset depreciation.............................     121,000      124,000
Accrued vacation.....................................     114,000      137,000
Intellectual property amortization...................          --       61,000
                                                       ----------   ----------
                                                        1,953,000    4,671,000
Less valuation allowance.............................          --   (4,491,000)
                                                       ----------   ----------
                                                       $1,953,000   $  180,000
                                                       ==========   ==========
</TABLE>

        At December 31, 1999, the Company has unused tax net operating loss
carryforwards of approximately $2,106,000 which expire in 2012, $1,828,000 which
expire in 2018 and $7,638,000 which will

                                      F-14
<PAGE>
                      TRANSGENOMIC, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

            YEARS ENDED DECEMBER 31, 1997, 1998 AND 1999 (CONTINUED)

I. INCOME TAXES (CONTINUED)
expire in 2019. Additionally, at December 31, 1999, the Company has unused
general business credits earned primarily through increased research
expenditures of approximately $131,000. These credits expire at various times
between 2010 and 2019. The Company's management believes that it is more likely
than not that the deferred tax asset of $180,000 will be realized through the
sale of the business discussed in Note R. A valuation allowance has been
provided in 1999 for the remaining deferred tax assets, due to the Company's
cumulative losses in recent years and an inability to utilize any additional
losses as carrybacks.

J. EMPLOYEE BENEFIT PLAN

        The Company maintains an employee savings plan which allows for
voluntary contributions into designated investment funds by eligible employees.
The Company matches the employees' contributions at the rate of 50% on the first
6% of contributions. The Company may at the discretion of its Board of
Directors, make additional contributions on behalf of the Plan's participants.
Company contributions were $92,733, $117,923 and $174,973 for the years ended
December 31, 1997, 1998 and 1999, respectively.

K. STOCKHOLDERS' EQUITY

    PRIVATE PLACEMENT

        The Company issued 2,000,000 shares of the Company's common stock, par
value $.01 per share (the "Stock"), at a price of $5.00 per share in a private
placement during 1997 and 1998 for net proceeds of $1,623,869 and $7,300,059,
respectively. A total of 1,524,500 shares of the 2,000,000 shares of common
stock were placed by Placement Agents pursuant to selling agent agreements. A 9%
commission was paid to each Placement Agent on all sales of the common stock
made by it and broker-dealers.

        The Company also issued warrants to the Placement Agents with an
exercise price of $5.00 per share (subject to certain cashless exercise rights)
which will have terms of five years expiring in 2003. Total shares eligible to
be purchased through these warrants were 152,450 at December 31, 1999 (see Note
L).

        In 1999, the Company issued convertible notes which can be converted
into a minimum of 2,400,000 common shares (see Note G).

    PREFERRED STOCK.

        The Company's Board of Directors is authorized to issue up to 15,000,000
shares of preferred stock in one or more series, from time to time, with such
designations, powers, preferences and rights and such qualifications,
limitations and restrictions as may be provided in a resolution or resolutions
adopted by the Board of Directors. The authority of the Board of Directors
includes, but is not limited to, the determination or fixing of the following
with respect to shares of such class or any series thereof: (i) the number of
shares; (ii) the dividend rate, whether dividends shall be cumulative and, if
so, from which date; (iii) whether shares are to be redeemable and, if so, the
terms and amount of any sinking fund providing for the purchase or redemption of
such shares; (iv) whether shares shall be convertible and, if so, the terms and
provisions thereof; (v) what restrictions are to apply, if any, on the issue or
reissue of any additional preferred stock; and (vi) whether shares have voting
rights. The preferred stock may be issued with a preference over the common
stock as to the payment of dividends.

                                      F-15
<PAGE>
                      TRANSGENOMIC, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

            YEARS ENDED DECEMBER 31, 1997, 1998 AND 1999 (CONTINUED)

K. STOCKHOLDERS' EQUITY (CONTINUED)
        The Company has no current plans to issue any series of preferred stock.
Classes of stock such as the preferred stock may be used, in certain
circumstances, to create voting impediments on extraordinary corporate
transactions or to frustrate persons seeking to effect a merger or otherwise to
gain control of the Company. For the foregoing reasons, any preferred stock
issued by the Company could have an adverse effect on the rights of the holders
of the common stock.

    COMMON STOCK.

        In March 2000, the Company's Board of Directors approved an increase in
the number of authorized common shares to 60,000,000, subject to the approval of
the Company's stockholders.

L. STOCK OPTIONS AND WARRANTS

        The Company adopted the 1997 Stock Option Plan in June of 1997 which was
last amended and restated on October 14, 1998. The Company's 1997 Stock Option
Plan (the "Stock Option Plan") allows the Company to grant both incentive stock
options and nonqualified stock options to acquire shares of the Company's common
stock to employees and directors of the Company and to nonemployee advisors.
Either incentive or non-qualified stock options may be granted to employees of
the Company, but only nonqualified stock options may be granted to nonemployee
directors and advisors. The maximum number of shares for which options may be
granted under the Stock Option Plan is 4,000,000. The Stock Option Plan is
administered by the Compensation Committee of the Board of Directors (the
"Committee") which has the authority to set the number, exercise price, term and
vesting provisions of the options granted under the Stock Option Plan, subject
to the terms thereof. The options must be granted at exercise prices not less
than the fair market value of the common stock on the date of the grant.
Generally, the stock options vest at a rate of 20% per year over a five year
period and expire 10 years after the date the option was granted. If the option
holder ceases to be employed by the Company, the Company will have the right to
terminate any outstanding but unexercised options. In March 2000, the Company's
Board of Directors approved an amendment to the Stock Option Plan to increase
the number of shares for which options can be granted to 6,000,000, subject to
the approval of the Company's stockholders.

                                      F-16
<PAGE>
                      TRANSGENOMIC, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

            YEARS ENDED DECEMBER 31, 1997, 1998 AND 1999 (CONTINUED)

L. STOCK OPTIONS AND WARRANTS (CONTINUED)
        The following table summarizes activity under the Stock Option Plan
during the three years ended December 31, 1999:

<TABLE>
<CAPTION>
                                                                      WEIGHTED
                                                                      AVERAGE
                                                          NUMBER OF   EXERCISE
                                                           OPTIONS     PRICE
                                                          ---------   --------
<S>                                                       <C>         <C>
Balance at Inception (June 1997):.......................         --     $ --
  Granted...............................................  1,515,000     5.00
  Exercised.............................................         --       --
  Canceled..............................................         --       --
                                                          ---------
Balance at December 31, 1997:...........................  1,515,000     5.00
  Granted...............................................  1,690,250     5.00
  Exercised.............................................         --       --
  Canceled..............................................         --       --
                                                          ---------
Balance at December 31, 1998:...........................  3,205,250     5.00
  Granted...............................................    590,250     5.00
  Exercised.............................................         --       --
  Canceled..............................................   (257,750)    5.00
                                                          ---------
Balance at December 31, 1999............................  3,537,750
                                                          =========
Exercisable at December 31, 1999........................  2,028,650
                                                          =========
</TABLE>

        The weighted average fair value of options granted in 1997, 1998 and
1999 was $1.34, $1.02 and $1.00, respectively. At December 31, 1999, the
weighted average remaining contractual life of options outstanding was 8.4
years.

        In 1997, the Company granted options to purchase 1.5 million shares at
$5.00 per share to an officer of the Company which are fully vested and
exercisable at December 31, 1997 and expire in 2007. The Company has also
granted options to purchase 15,000 shares to a member of the Company's Board of
Directors at an exercise price which is the lower of (a) $5.00 per share or (b)
50% of the price per share at which the Company offers common stock in an
initial public offering, of which 9,000 shares are vested and exercisable at
December 31, 1999. The remaining options issued in 1997 vest over two years and
expire in 2002.

        The Company has elected to follow the measurement provisions of
Accounting Principles Board Opinion No. 25, under which no recognition of
expense is required in accounting for stock options granted to employees for
which the exercise price equals or exceeds the deemed fair market value of the
stock at the grant date. In those cases where options have been granted with an
exercise price below the deemed fair market value, the Company recognizes
compensation expense over the vesting period using the aggregated percentage of
compensation accrued method as prescribed by Financial Accounting Standards
Board Interpretation No. 28. During December 1999, the Company recorded unearned
compensation of $112,500 for options granted with exercise prices less than the
deemed fair market value at the date of grant.

                                      F-17
<PAGE>
                      TRANSGENOMIC, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

            YEARS ENDED DECEMBER 31, 1997, 1998 AND 1999 (CONTINUED)

L. STOCK OPTIONS AND WARRANTS (CONTINUED)
        Pro forma information regarding net income and income per share is
required by Statement of Financial Accounting Standard No. 123, ACCOUNTING FOR
STOCK-BASED COMPENSATION, (SFAS No. 123) assuming the Company accounted for its
employee stock options using the fair value method. The fair value of each stock
option granted is estimated at the date of grant using the Black-Scholes option
pricing model with the following weighted-average assumptions for options
granted in 1997, 1998 and 1999, respectively: no common stock dividends,
risk-free interest rates ranging from 5.44% and 5.74% to 6.33% and 5.51% to
6.13%; no volatility (prior to becoming a public company); and an expected
option life of five years. Pro forma net income and income per share assuming
compensation expense for the Stock Option Plan had been determined under SFAS
No. 123, are as follows:

<TABLE>
<CAPTION>
                                             1997          1998          1999
                                          -----------   -----------   -----------
<S>                                       <C>           <C>           <C>
Net Loss:
  As reported...........................  $(2,409,539)  $(1,576,393)  $(9,826,886)
  Pro forma.............................   (4,421,148)   (1,662,641)   (9,974,172)

Basic and diluted loss per share:
  As reported...........................        (0.22)        (0.13)        (0.76)
  Pro forma.............................        (0.40)        (0.14)        (0.77)
</TABLE>

        In the first quarter of fiscal 2000, the Company granted 212,500
options, including 72,000 options with exercise prices at $5.00 per share and
will record unearned compensation in connection with these grants.

        During 1998, the Company issued warrants to purchase 152,450 shares of
common stock pursuant to placement agent agreements (see Note K). On December
16, 1997, the Company issued a warrant to purchase 300,000 shares of common
stock pursuant to a Securities Purchase Agreement (see Note M).

M. RELATED PARTY TRANSACTIONS

    CT PARTNERS.

        The Company and CT Partners were related parties through common
ownership. The Company provided research and development services for CT
Partners at cost. The cost of these services amounted to $650,782 and $318,800
for the years ended December 31, 1996 and 1997, respectively. There were no
research and development services provided subsequent to 1997 as the technology
involved was fully developed. These amounts are included in note
receivable--related party, along with accrued interest and administration fees
of $116,349 at December 31, 1998. The Company also performs contract research
and development services for unaffiliated entities.

        On June 27, 1997 the Company entered into a royalty agreement with CT
Partners in which the Company received an exclusive license to manufacture and
market a miniature solid-state optical spectrometer developed by CT Partners.
This agreement was amended on December 1, 1997. Under the terms of the amended
royalty agreement, the Company would pay a royalty to CT Partners equal to a
maximum of $6.5 million. The first $1.5 million would be paid upon achieving $3
million in sales of products employing the licensed technology or from a sale of
the technology. Subsequent royalty payments

                                      F-18
<PAGE>
                      TRANSGENOMIC, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

            YEARS ENDED DECEMBER 31, 1997, 1998 AND 1999 (CONTINUED)

M. RELATED PARTY TRANSACTIONS (CONTINUED)
would equal 10% of gross revenues received by the Company from the licensed
technology, payable quarterly. At December 31, 1998, CT Partners owed the
Company $1,085,931 for contract research and development expenses incurred in
connection with this agreement.

        In June 1999, the Company and CT Partners entered into an Asset Purchase
Agreement whereby the parties terminated the royalty agreement and the Company
purchased all intellectual property previously developed for CT Partners for $2
million in cash, less the outstanding note receivable of $1,085,931 and certain
related expenses. The Company is amortizing the intellectual property over 5
years.

    SECURITIES PURCHASE AGREEMENT.

        On December 16, 1997, the Company entered into a Securities Purchase
Agreement with a private investor who subsequently was elected as a director of
the Company, pursuant to which the private investor purchased from the Company a
secured promissory note in the principal amount of $1,500,000 (the "$1,500,000
Note") and a warrant to purchase 300,000 shares of common stock (the "300,000
Share Warrant"), subject to adjustment. The agreement allowed the purchase of
additional debt securities from the Company. In February 1998, the Company was
informed, as allowed by the agreement, that no additional debt securities would
be purchased. Therefore, in accordance with the terms of the agreement, in 1998
the Company paid the $1,500,000 Note plus interest and other agreed-to expenses.
The private investor is no longer a director of the Company.

        The 300,000 Share Warrant entitles the holder to acquire 300,000 shares
of common stock at the lower of (a) $5.00 per share or (b) 50% of the price per
share at which the Company offers common stock in an initial public offering.
The 300,000 Share Warrant will expire if it has not been exercised on or before
the Company's initial public offering. The warrants were valued at $82,117 at
December 31, 1997 using the Black-Scholes pricing model with the following
assumptions: no common stock dividends, risk free interest rate of 5.71%;
expected life of 12 months; and no volatility. These warrants were completely
amortized as of December 31, 1998.

N. COMMITMENTS AND CONTINGENCIES

        The Company is not a party to any material legal proceedings.

        In May 1998, the Company elected to self-insure the majority of its
employees' health care coverage with lifetime coverage up to $2,000,000 and
$5,000,000 per person at December 31, 1998 and 1999, respectively. In place are
reinsurance policies limiting losses for any individual within the plan of
$10,000 per year, and a total company aggregate stop-loss limit at December 31,
1999 of approximately $282,000, with coverage up to $2,282,000 of aggregated
total claims. Based on estimated claims and the reinsurance in place, management
believes the costs are reasonably estimated in the financial statements.

O. SALES AND PRODUCT INFORMATION

        The Company believes it is advantageous to operate on a fully integrated
basis in one operating segment. Accordingly, management of the Company evaluates
performance and determines the allocation

                                      F-19
<PAGE>
                      TRANSGENOMIC, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

            YEARS ENDED DECEMBER 31, 1997, 1998 AND 1999 (CONTINUED)

O. SALES AND PRODUCT INFORMATION (CONTINUED)
of resources on an entity-wide basis. There are no material long-lived assets
held outside the United States. The following is supplemental information for
net sales by geographic area and product group:

<TABLE>
<CAPTION>
                                            1997          1998          1999
                                         -----------   -----------   -----------
<S>                                      <C>           <C>           <C>
Sales by Geographic Area:
  North America........................  $ 6,714,473   $10,414,492   $10,402,434
  Europe...............................    3,009,936     6,248,695     9,286,394
  Pacific Rim..........................    1,620,735     1,704,190     2,992,099
  Other................................      231,533       568,063       354,027
                                         -----------   -----------   -----------
Total..................................  $11,576,677   $18,935,440   $23,034,954
                                         ===========   ===========   ===========
Sales by Product Group:
  Bio-Systems..........................  $   295,000   $ 5,460,684   $11,218,887
  Bio-Consumables......................        2,275       209,814     1,435,702
  Scientific Instruments...............    9,410,072    11,496,105     8,794,165
  Other Consumables....................    1,869,330     1,768,837     1,586,200
                                         -----------   -----------   -----------
Total..................................  $11,576,677   $18,935,440   $23,034,954
                                         ===========   ===========   ===========
</TABLE>

P. SUPPLEMENTAL CASH FLOW INFORMATION

<TABLE>
<CAPTION>
                                                        1997       1998        1999
                                                      --------   --------   ----------
<S>                                                   <C>        <C>        <C>
Noncash investing and financing activities:
  Exchange of note receivable for intellectual
    property........................................    $ --       $ --     $1,085,931
  Liabilities assumed in connection with business
    acquisitions....................................    $ --       $ --     $  135,333
</TABLE>

Q. ALLOWANCE FOR DOUBTFUL ACCOUNTS

        The following is a summary of activity for the allowance for doubtful
acounts during each of the three years ended December 31, 1999:

<TABLE>
<CAPTION>
                                                                 ADDITIONAL
                                                     BEGINNING    CHARGES      DEDUCTIONS     ENDING
                                                      BALANCE    TO INCOME    FROM RESERVE   BALANCE
                                                     ---------   ----------   ------------   --------
<S>                                                  <C>         <C>          <C>            <C>
Year Ended December 31, 1997.......................   $    --     $102,495      $  (2,495)   $100,000
Year Ended December 31, 1998.......................   100,000      462,698         (1,053)    561,645
Year Ended December 31, 1999.......................   561,645      121,609       (522,661)    160,593
</TABLE>

R. SUBSEQUENT EVENTS

        On March 7, 2000, the Company signed a letter of intent for the sale of
the assets of its non-life sciences instrument product line to a director of the
Company for $6,000,000, of which $5,000,000 will be paid in cash and $1,000,000
will be paid with an interest-bearing promissory note due on March 31, 2001. The
non-life science instrument product line contributed revenues of $8,794,165 in
1999. The Company expects this transaction to close on March 31, 2000, subject
to the approval of the Company's stockholders.

                                      F-20
<PAGE>
                   UNAUDITED PRO FORMA FINANCIAL INFORMATION

        The following unaudited pro forma statement of operations for the year
ended December 31, 1999 reflects the sale of assets related to our non-life
sciences instrument product line (The Company as adjusted) and the issuance of
300,000 shares of common stock at $5.00 per share upon the exercise of warrants
that will expire at the close of this offering, as if each had occurred on
January 1, 1999 and the assumed conversion at $5.00 per share of the $12.0
million aggregate principal amount of our convertible notes and accrued interest
into 2,712,200 shares of common stock as of March 23, 1999, the date of issuance
of our convertible notes. The following unaudited pro forma balance sheet
reflects these transactions and the sale of 25,000 shares of common stock at
$5.00 per share in March 2000 as if each had been completed on December 31,
1999.

        The unaudited pro forma statement of operations and balance sheet data
reflect all adjustments necessary in the opinion of the Company's management
(consisting only of normal recurring adjustments) for a fair presentation of
such data. The unaudited pro forma financial data reflects the preliminary
identification of the non-life science instruments assets to be sold by the
Company. We expect to finalize the identification of the assets to be sold at
the time of closing.

        The unaudited financial data are intended for informational purposes
only and are not intended to be indicative of our results of operations or
financial position had these transactions occurred on the dates specified, nor
are they indicative of our future results of operations or financial position.

        The unaudited pro forma financial data, including notes thereto, should
be read in conjunction with our historical consolidated financial statements,
including notes thereto, appearing elsewhere in this Prospectus.

                                      F-21
<PAGE>
                               TRANSGENOMIC, INC.

                       UNAUDITED PRO FORMA BALANCE SHEET

                               DECEMBER 31, 1999

<TABLE>
<CAPTION>
                                                 ADJUSTMENTS
                                                 FOR SALE OF
                                                  NON-LIFE                    ADJUSTMENTS FOR
                                                  SCIENCES                      CONVERTIBLE
                                                 INSTRUMENT                       NOTES,
                                      THE          PRODUCT         THE           WARRANTS
                                    COMPANY         LINE         COMPANY          & STOCK           PRO
                                      (1)           (2A)       AS ADJUSTED       (2B,C,D)          FORMA
                                  ------------   -----------   ------------   ---------------   ------------
<S>                               <C>            <C>           <C>            <C>               <C>
ASSETS

CURRENT ASSETS:
  Cash and cash equivalents.....  $    153,336   $5,000,000    $ 5,153,336     $  1,750,000     $  6,903,336
  Accounts receivable, net......     6,199,059           --      6,199,059               --        6,199,059
  Note receivable...............                  1,000,000      1,000,000               --        1,000,000
  Inventories...................     6,043,025   (2,833,354)     3,209,671               --        3,209,671
  Prepaid expenses and other
    current assets..............       527,461           --        527,461               --          527,461
  Refundable income taxes.......        96,000           --         96,000               --           96,000
                                  ------------   -----------   ------------    ------------     ------------
    Total current assets........    13,018,881    3,166,646     16,185,527        1,750,000       17,935,527
PROPERTY AND EQUIPMENT, Net.....     2,581,139     (704,478)     1,876,661               --        1,876,661
OTHER ASSETS....................     4,363,490   (2,261,389)     2,102,101               --        2,102,101
                                  ------------   -----------   ------------    ------------     ------------
                                  $ 19,963,510   $  200,779    $20,164,289     $  1,750,000     $ 21,914,289
                                  ============   ===========   ============    ============     ============

LIABILITIES AND STOCKHOLDERS EQUITY (DEFICIT)

CURRENT LIABILITIES
  Notes payable--bank...........  $  4,340,000   $       --    $ 4,340,000               --     $  4,340,000
  Current portion of notes
    payable--other..............       579,724           --        579,724               --          579,724
  Accounts payable..............     2,827,186           --      2,827,186               --        2,827,186
  Accrued compensation..........       666,219           --        666,219               --          666,219
  Other accrued expenses........     1,111,871     (112,285)       999,586               --          999,586
                                  ------------   -----------   ------------    ------------     ------------
    Total current liabilities...     9,525,000     (112,285)     9,412,715               --        9,412,715
NOTES PAYABLE--other, less
  current maturities............       116,958           --        116,958               --          116,958
CONVERTIBLE NOTES PAYABLE.......    12,421,010           --     12,421,010      (12,421,010)              --
STOCKHOLDERS' EQUITY (DEFICIT)
  Preferred stock...............            --           --             --                                --
  Common stock..................       130,000           --        130,000           30,372          160,372
  Additional paid-in capital....    10,231,595           --     10,231,595       14,140,638       24,372,233
  Unearned compensation.........      (112,500)          --       (112,500)              --         (112,500)
  Accumulated deficit...........   (12,344,075)     313,064    (12,031,011)              --      (12,031,011)
  Accumulated other
    comprehensive loss..........        (4,478)          --         (4,478)              --           (4,478)
                                  ------------   -----------   ------------    ------------     ------------
    Total stockholders' equity
      (deficit).................    (2,099,458)     313,064     (1,786,394)      14,171,010       12,384,616
                                  ------------   -----------   ------------    ------------     ------------
                                  $ 19,963,510   $  200,779    $20,164,289     $  1,750,000     $ 21,914,289
                                  ============   ===========   ============    ============     ============
</TABLE>

            SEE NOTES TO UNAUDITED PRO FORMA FINANCIAL INFORMATION.

                                      F-22
<PAGE>
                               TRANSGENOMIC, INC.

                  UNAUDITED PRO FORMA STATEMENT OF OPERATIONS

                      FOR THE YEAR ENDED DECEMBER 31, 1999

<TABLE>
<CAPTION>
                                                ADJUSTMENTS
                                                FOR SALE OF
                                                 NON-LIFE                          ADJUSTMENTS
                                                 SCIENCES                              FOR
                                      THE       INSTRUMENT              THE        CONVERTIBLE
                                    COMPANY       PRODUCT             COMPANY         NOTES          PRO
                                      (1)          LINE             AS ADJUSTED        (4)          FORMA
                                  -----------   -----------         ------------   -----------   -----------
<S>                               <C>           <C>                 <C>            <C>           <C>
NET SALES.......................  $23,034,954   $8,794,165 (3a)     $ 14,240,789          --     $14,240,789
COST OF GOODS SOLD..............   12,090,036    4,924,757 (3a,b)      7,165,279          --       7,165,279
                                  -----------   ----------          ------------    --------     -----------
    Gross profit................   10,944,918    3,869,408             7,075,510          --       7,075,510
OPERATING EXPENSES
  General and administrative....    3,771,663      236,808 (3b,c)      3,534,855          --       3,534,855
  Marketing and sales...........    7,759,997    1,610,369 (3b)        6,149,628          --       6,149,628
  Research and development......    6,296,859    1,728,827 (3b)        4,568,032          --       4,568,032
                                  -----------   ----------          ------------    --------     -----------
                                   17,828,519    3,576,004            14,252,515          --      14,252,515
                                  -----------   ----------          ------------    --------     -----------
LOSS FROM OPERATIONS............   (6,883,601)     293,404            (7,177,005)         --      (7,177,005)
OTHER INCOME (EXPENSE)
  Interest expense, net.........   (1,198,378)          --            (1,198,378)    858,665        (339,713)
  Other, net....................          366           --                   366          --             366
                                  -----------   ----------          ------------    --------     -----------
                                   (1,198,012)          --            (1,198,012)    858,665        (339,347)
                                  -----------   ----------          ------------    --------     -----------
LOSS BEFORE INCOME TAXES........   (8,081,613)     293,404            (8,375,017)    858,665      (7,516,352)
INCOME TAX EXPENSE..............    1,745,273           --             1,745,273          --       1,745,273
                                  -----------   ----------          ------------    --------     -----------
NET LOSS........................  $(9,826,886)  $  293,404          $(10,120,290)   $858,665     $(9,261,625)
                                  ===========   ==========          ============    ========     ===========
BASIC AND DILUTED LOSS PER
  SHARE.........................  $     (0.76)                      $      (0.78)                $     (0.60)
                                  ===========                       ============                 ===========
BASIC AND DILUTED WEIGHTED
  AVERAGE SHARES OUTSTANDING
  (5)...........................   13,000,000                         13,000,000                  15,334,150
                                  ===========                       ============                 ===========
</TABLE>

            SEE NOTES TO UNAUDITED PRO FORMA FINANCIAL INFORMATION.

                                      F-23
<PAGE>
               NOTES TO UNAUDITED PRO FORMA FINANCIAL INFORMATION

        On March 7, 2000, we signed into a letter of intent for the sale of
assets related to our non-life sciences instrument product line for a total
purchase price of $6 million, of which $5 million will be paid in cash and $1
million will be paid with an interest-bearing promissory note due on March 31,
2000. The note will bear interest at a market rate. The unaudited pro forma
statement of operations for the year ended December 31, 1999 reflects this sale
and the issuance of 300,000 shares of common stock at $5.00 per share upon the
exercise of warrants that will expire at the close of this offering, as if each
had occurred on January 1, 1999 and the assumed conversion at $5.00 per share of
our $12.0 million aggregate principal amount of our convertible notes and
accrued interest into 2,712,200 shares of common stock as of March 23, 1999
(date of issuance). The unaudited pro forma balance sheet reflects these
transactions and the sale of 25,000 shares of common stock at $5.00 per share in
March 2000, as if each had been completed on December 31, 1999. The unaudited
pro forma financial data are based on the following:

1.  The December 31, 1999 historical consolidated financial statements of the
    Company.

2.  The pro forma balance sheet adjustments are as follows:

    a.  The adjustments to reflect the sale of the Company's non-life sciences
       instrument product line as follows:

<TABLE>
<S>                                                     <C>          <C>
Inventories...........................................  $2,833,354
Property, net.........................................     704,478
Other assets..........................................   2,081,389
Accrued liabilities...................................    (112,285)
                                                        ----------
Net assets sold.......................................   5,506,936

Purchase Price:
  Cash................................................   5,000,000
  Note Receivable.....................................   1,000,000   6,000,000
                                                        ----------   ---------
  Preliminary gain on sale............................                 493,064
  Utilization of deferred tax benefit.................                (180,000)
                                                                     ---------
Net adjustment to equity..............................               $ 313,064
                                                                     =========
</TABLE>

    b.  The assumed conversion at $5.00 per share of our convertible notes and
       accrued interest into 2,712,200 shares of common stock and elimination of
       related interest and redemption premium.

    c.  The receipt of $1.5 million in cash upon issuance of 300,000 shares of
       common stock at $5.00 per share upon exercise of warrants.

    d.  The receipt of $250,000 in cash upon sale of 25,000 shares of common
       stock at $10.00.

3.  The pro forma statement of operations adjustments for the sale of the
    Company's non-life sciences instrument product line are as follows:

    a.  Elimination of the actual historical revenues and direct cost of goods
       sold.

    b.  Elimination of indirect manufacturing and operating expenses. The
       elimination of these expenses is based on an allocation of all department
       expenses based on the ratio of actual individual employees' wages for
       such department in proportion to total Company wages. The Company's
       management believes such method is reasonable.

    c.  An increase in general and administrative expenses to reflect $200,000
       of anticipated increased rental costs, which will be incurred by the
       Company as a result of the sale of the non-life

                                      F-24
<PAGE>
       sciences instrument product line. The Company will be required to
       relocate to a separate facility subsequent to the sale. This adjustment
       is reflected as follows:

<TABLE>
<S>                                                           <C>
Elimination of the non-life sciences instrument product
  line's proportionate share of general and administrative
  expenses..................................................  $  436,808
Anticipated increased rental costs..........................    (200,000)
                                                              ----------
Net reduction in general and administrative expenses........  $  236,808
                                                              ==========
</TABLE>

    d.  No tax adjustment has been made due to the Company's current net
       operating loss position.

4.  The elimination of historical interest and redemption premium associated
    with the convertible notes. (See Note G to the historical consolidated
    financial statements.)

5.  The weighted average shares outstanding are computed as follows:

<TABLE>
<S>                                                           <C>
Historical weighted average shares..........................  13,000,000
Shares issued upon conversion of notes and accrued interest
  (2,712,200 x 9/12)........................................   2,034,150
Shares issued upon exercise of warrants.....................     300,000
                                                              ----------
                                                              15,334,150
                                                              ==========
</TABLE>

                                      F-25
<PAGE>
                 A picture depicting the WAVE System components
<PAGE>
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------

                                4,000,000 SHARES

                                     [LOGO]

                                  COMMON STOCK

                                ---------------
                                   PROSPECTUS
                               ------------------

                                   CHASE H&Q
                            BEAR, STEARNS & CO. INC.
                             DAIN RAUSCHER WESSELS

                              --------------------

                                         , 2000

                              --------------------

        YOU SHOULD RELY ONLY ON INFORMATION CONTAINED IN THIS PROSPECTUS. WE
HAVE NOT AUTHORIZED ANYONE TO PROVIDE YOU WITH INFORMATION DIFFERENT FROM THAT
CONTAINED IN THIS PROSPECTUS. WE ARE OFFERING TO SELL, AND SEEKING OFFERS TO
BUY, SHARES OF COMMON STOCK ONLY IN JURISDICTIONS WHERE OFFERS AND SALES ARE
PERMITTED. THE INFORMATION CONTAINED IN THIS PROSPECTUS IS ACCURATE ONLY AS OF
THE DATE OF THIS PROSPECTUS, REGARDLESS OF THE TIME OF DELIVERY OF THIS
PROSPECTUS OR OF ANY SALE OF OUR COMMON STOCK.

        NO ACTION IS BEING TAKEN IN ANY JURISDICTION OUTSIDE THE UNITED STATES
TO PERMIT A PUBLIC OFFERING OF THE COMMON SHARES OR POSSESSION OR DISTRIBUTION
OF THIS PROSPECTUS IN THAT JURISDICTION. PERSONS WHO COME INTO POSSESSION OF
THIS PROSPECTUS IN JURISDICTIONS OUTSIDE THE UNITED STATES ARE REQUIRED TO
INFORM THEMSELVES ABOUT AND TO OBSERVE ANY RESTRICTIONS AS TO THIS OFFERING AND
THE DISTRIBUTION OF THIS PROSPECTUS APPLICABLE TO THAT JURISDICTION.

        UNTIL      , 2000 (25 DAYS AFTER THE DATE OF THIS PROSPECTUS), ALL
DEALERS THAT EFFECT TRANSACTIONS IN THESE SHARES OF COMMON STOCK MAY BE REQUIRED
TO DELIVER A PROSPECTUS. THIS IS IN ADDITION TO THE DEALER'S OBLIGATIONS TO
DELIVER A PROSPECTUS WHEN ACTING AS AN UNDERWRITER AND WITH RESPECT TO THEIR
UNSOLD ALLOTMENTS OR SUBSCRIPTIONS.

- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
<PAGE>
                                    PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 13:  OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION

        The following table sets forth the expenses (other than the underwriting
discount and commissions) expected to be incurred by us while issuing and
distributing the securities registered pursuant to this Registration Statement.
All amounts other than the SEC registration fee, NASD filing fee and Nasdaq
National Market listing fee are estimates.

<TABLE>
<S>                                                           <C>
SEC registration fee........................................  $                   17,002
NASD filing fee.............................................                       6,940
Nasdaq National Market listing fee..........................                    *[     ]
Legal fees and expenses.....................................                    *[     ]
Accounting fees and expenses................................                    *[     ]
Printing and engraving......................................                    *[     ]
Blue sky fees and expenses (including legal fees)...........                    *[     ]
Transfer agent fees.........................................                    *[     ]
Miscellaneous...............................................
                                                              --------------------------
  Total.....................................................  $
                                                              ==========================
</TABLE>

- ------------------------

*   To be provided by amendment.

ITEM 14: INDEMNIFICATION OF DIRECTORS AND OFFICERS

        Section 145 of the Delaware General Corporation Law authorizes a court
to award, or a corporation to grant, indemnity to directors and officers in
terms sufficiently broad to permit such indemnification under certain
circumstances for liabilities (including reimbursement of expenses incurred)
arising under the Securities Act of 1933.

        As permitted by the Delaware General Corporation Law, our Restated
Certificate of Incorporation eliminates the personal liability of its directors
for monetary damages for breach of fiduciary duty as a director, except for
liability (1) for any breach of the director's duty of loyalty to us or its
stockholders, (2) for acts or omissions not in good faith or that involve
intentional misconduct or a knowing violation of law, (3) under Section 174 of
the Delaware General Corporation Law (regarding unlawful dividends and stock
purchases) or (4) for any transaction from which the director derived an
improper personal benefit. If the Delaware General Corporation Law is amended to
authorize further elimination or limiting of directors' personal liability, then
the Restated Certificate provides that the personal liability of directors will
be eliminated or limited to the fullest extent provided under the Delaware
General Corporation Law.

        As permitted by the Delaware General Corporation Law, our Restated
Certificate of Incorporation and our Bylaws provide that (1) we are required to
indemnify our directors and officers to the fullest extent permitted by the
Delaware General Corporation Law, subject to certain very limited exceptions,
(2) we may indemnify our other employees and agents as set forth in the Delaware
General Corporation Law, (3) we are required to advance expenses, as incurred,
to its directors and executive officers in connection with a legal proceeding to
the fullest extent permitted by the Delaware General Corporation Law, subject to
certain conditions and (4) the rights conferred by the Restated Certificate of
Incorporation and Bylaws are not exclusive.

                                      II-1
<PAGE>
        The Delaware General Corporation Law authorizes a corporation to
indemnify its directors and officers provided that the corporation shall not
eliminate or limit the liability of a director as follows:

    (a)  for any action brought by or in the right of a corporation where the
director or officer is adjudged to be liable to the corporation, except where a
court determines the director or officer is entitled to indemnity;

    (b) for acts or omissions not in good faith or which involve conduct that
the director or officer believes is not in the best interests of the
corporation;

    (c)  for knowing violations of the law;

    (d) for any transaction from which the directors derived an improper
personal benefit; and

    (e) for payment of dividends or approval of stock repurchases or redemptions
leading to liability under Section174 of the Delaware General Corporation Law.

        The Delaware General Corporation Law requires a corporation to indemnify
a director or officer to the extent that the director or officer has been
successful, on the merits or otherwise, in defense of any action, suit or
proceeding for which indemnification is lawful.

        We maintain a director and officer insurance policy which insures our
directors and officers against damages, judgments, settlements and costs
incurred by reason of certain wrongful acts committed by such persons in their
capacities as directors and officers.

        Reference is also made to the form of Underwriting Agreement filed as
Exhibit 1 to this Registration Statement for our and the Underwriters'
respective agreements to indemnify each other, and to provide contribution in
circumstances where indemnification is unavailable.

ITEM 15:  RECENT SALES OF UNREGISTERED SECURITIES

        We have sold and issued the following securities since January 1, 1997:

    A.  On July 1, 1997, we issued a total of 11,000,000 shares of our Common
Stock to the shareholders of CETAC Holding Company, Inc. in connection with a
merger of that corporation with and into the Registrant.

    B.  On December 16, 1997, we issued a $1,500,000 promissory note and a
warrant to purchase 300,000 shares of our Common Stock to a venture capital
investor. Principal and interest on the promissory note was paid in full in June
1998. The warrant remains outstanding and has an exercise price of equal to the
lower of (i) $5.00 per share or (ii) 50% of the offering price of our Common
Stock in our initial public offering, subject to certain adjustments.

    C.  At various times between July 3, 1997 and December 31, 1998, we issued a
total of 2,000,000 shares of our Common Stock for an aggregate consideration of
$10,000,000 to various institutional and individual investors. We paid aggregate
cash commissions of $781,600 to various placement agents in connection with this
private offering.

    D.  In connection with the private offering of Common Stock described in
Item C above, we issued warrants for the purchase of a total of 152,450 shares
of our Common Stock to various placement agents that participated in such
offering. All warrants have an exercise price of equal to the lower of (i) $5.00
per share or (ii) 50% of the offering price of our Common Stock in our initial
public offering, subject to certain adjustments.

    E.  On March 23, 1999, we issued Convertible Notes in an aggregate principal
amount of $12,000,000 to various institutional and individual investors. The
Convertible Notes and interest accrued thereon are convertible into shares of
our Common Stock at a price equal to the lower of (i) $5.00 per

                                      II-2
<PAGE>
share or (ii) 50% of the offering price of our Common Stock in our initial
public offering, subject to certain adjustments.

    F.  On March 4, 2000, we issued 25,000 shares of Common Stock to a newly
elected director for a total purchase price of $250,000.

    G.  We have granted stock options to employees, directors and advisors under
our Employee Stock Option Plan as follows:

<TABLE>
<CAPTION>
                                                            NUMBER OF SHARES(1)   EXERCISE PRICE
                                                            -------------------   --------------
<S>                                                         <C>                   <C>
January 1, 1997 to December 31, 1997......................       1,515,000           $5.00(2)
January 1, 1998 to December 31, 1998......................       1,690,250             $5.00
January 1, 1999 to December 31, 1999......................         590,250             $5.00
January 1, 2000 to present................................         212,500        $5.00 to $10.00
                                                                 ---------
Total.....................................................       4,008,000
</TABLE>

- ------------------------

(1) Prior to cancellations of options to acquire 283,750 shares.

(2) Except that options for 15,000 shares issued to one of our non-employee
    directors may be exercised at the lower of $5.00 per share or 50% of the
    price of our common stock in this offering.

        The above securities were offered and sold by us in reliance upon the
exemptions from registration pursuant to either (1) Section 4(2) of the
Securities Act of 1933 as transactions not involving any public offering or
(2) Rule 701 promulgated under the Securities Act of 1933. No underwriters were
involved in connection with the sales of securities referred to in this Item 15.

ITEM 16:  EXHIBITS AND FINANCIAL STATEMENTS; SCHEDULES

(a)  Exhibits.

<TABLE>
<C>    <S>
    1  Form of Underwriting Agreement*
    2  Asset Purchase Agreement between the Registrant and Stephen
       F. Dwyer*
  3.1  First Amended and Restated Certificate of Incorporation of
       the Registrant
  3.2  Bylaws of the Company
    4  Form of Certificate of the Company's Common Stock
    5  Opinion of Kutak Rock LLP*
 10.1  Warrant for Purchase of Common Stock, dated December 16,
       1997, between the Registrant and G.S. Beckwith Gilbert
 10.2  Registration Rights Agreement, dated December 16, 1997,
       between the Registrant and G.S. Beckwith Gilbert
 10.3  Form of Warrant for Purchase of Common Stock between the
       Registrant and various Placement Agents and Schedule of
       Warrants Issued
 10.4  First Amended and Restated Shareholder Agreement, dated
       July 1, 1997, between the Registrant and each holder of its
       Common Stock
 10.5  Subscription Agreement, dated March 23, 1999, between the
       Registrant and each purchaser of Registrant's Convertible
       Notes due March 25, 2002, including form of Convertible Note
 10.6  Second Amended and Restated 1997 Stock Option Plan of the
       Registrant
 10.7  1999 UK Approved Stock Option Sub Plan of the Registrant
 10.8  Employment Agreement, dated March 4, 2000, between the
       Registrant and Colin J. D'Silva
 10.9  Employment Agreement, dated March 4, 2000, between the
       Registrant and John L. Allbery
10.10  Employment Agreement, dated March 4, 2000, between the
       Registrant and Douglas T. Gjerde
10.11  Employment Agreement, dated November 16, 1998, between the
       Registrant and William B. Walker
10.12  Letter Agreement, dated February 18, 2000, between the
       Registrant and Gregory J. Duman
10.13  Amended and Restated Revolving Loan Agreement, dated
       March 8, 2000, between the Registrant and First National
       Bank of Omaha
</TABLE>

                                      II-3
<PAGE>
<TABLE>
<C>    <S>
10.14  License Agreement, dated September 1, 1994, between
       Registrant and Professor Dr. Gunther Bonn, et. al. and
       Amendment thereto, dated March 14, 1997+
10.15  License Agreement, dated August 20, 1997, between the
       Registrant and Leland Stanford Junior University+
10.16  Supply Agreement, dated January 1, 2000, between the
       Registrant and Hitachi Instruments*+
10.17  Lease Agreement, dated November 2, 1998, between the
       Registrant and Westlake Development Company, Inc.
10.18  Lease Agreement, dated May 15, 1996, between Interaction
       Chromatography Inc. and Westlake Development Co., Inc.
   21  Subsidiaries of the Registrant
 23.1  Consent of Deloitte & Touche LLP
 23.2  Consent of Kutak Rock LLP (included in Exhibit 5)*
   24  Powers of Attorney
   27  Financial Data Schedule
</TABLE>

- ------------------------

*   To be filed by amendment.

+  Certain confidential portions of this Exhibit were omitted by means of
    redacting a portion of the text. This Exhibit has been filed separately with
    the Secretary of the Commission with the redacted text pursuant to the
    Registrant's Application Requesting Confidential Treatment under Rule 406 of
    the Securities Act.

(b) Financial Statement Schedules:

        All financial statement schedules have been omitted because the required
information is included in the consolidated financial statements of the
Registrant or related notes thereto.

        ITEM 17:  UNDERTAKINGS  The following undertakings correspond to the
specified paragraph designation from Item 512 of Regulation S-K.

    (f)  EQUITY OFFERING OF NONREPORTING REGISTRANT.  We hereby undertake to
provide to the underwriters at the closing specified in the underwriting
agreement certificates in such denominations and registered in such names as
required by the underwriters to permit prompt delivery to each purchaser.

    (h)  ACCELERATION OF EFFECTIVENESS.  Insofar as indemnification for
liabilities arising under the Securities Act of 1933 may be permitted to
directors, officers and controlling persons of the registrant pursuant to the
foregoing provisions, or otherwise, the registrant has been advised that in the
opinion of the Securities and Exchange Commission such indemnification is
against public policy as expressed in the Act and is, therefore, unenforceable.
In the event that a claim for indemnification against such liabilities (other
than the payment by the registrant of expenses incurred or paid by a director,
officer or controlling person of the registrant in the successful defense of any
action, suit or proceeding) is asserted by such director, officer or controlling
person in connection with the securities being registered, the registrant will,
unless in the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the Act and
will be governed by the final adjudication of such issue.

    (i)  RULE 430A.  The undersigned registrant hereby undertakes that:

        (1) For purposes of determining any liability under the Securities Act
    of 1933, the information omitted from the form of prospectus filed as part
    of this registration statement in reliance upon Rule 430A and contained in a
    form of prospectus filed by the registrant pursuant to Rule 424(b)(1) or
    (4) or 497(h) under the Securities Act shall be deemed to be part of this
    registration statement as of the time it was declared effective.

        (2) For the purpose of determining any liability under the Securities
    Act of 1933, each post-effective amendment that contains a form of
    prospectus shall be deemed to be a new registration statement relating to
    the securities offered therein, and the offering of such securities at that
    time shall be deemed to be the initial bona fide offering thereof.

                                      II-4
<PAGE>
                                   SIGNATURES

        Pursuant to the requirements of the Securities Act of 1933, we have duly
caused this Registration Statement to be signed on its behalf by the
undersigned, thereunto duly authorized, in the City of Omaha and State of
Nebraska, on the 10th day of March 2000.

<TABLE>
<S>                                                    <C>  <C>
                                                       TRANSGENOMIC, INC.

                                                       By:            /s/ COLLIN J. D'SILVA
                                                            -----------------------------------------
                                                                        Collin J. D'Silva
                                                               CHAIRMAN AND CHIEF EXECUTIVE OFFICER
</TABLE>

        Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities indicated as of the 10th day of March 2000.

<TABLE>
<CAPTION>
                      SIGNATURE                                            TITLE
                      ---------                                            -----
<C>                                                    <S>
                /s/ COLLIN J. D'SILVA                  Chairman of the Board, Director and Chief
     -------------------------------------------         Executive Officer (Principal Executive
                  Collin J. D'Silva                      Officer)

                 /s/ JOHN L. ALLBERY
     -------------------------------------------       Chief Financial Officer (Principal Financial
                   John L. Allbery                       Officer)

               /s/ MITCHELL L. MURPHY
     -------------------------------------------       Controller (Chief Accounting Officer)
                 Mitchell L. Murphy

                /s/ STEPHEN F. DWYER*
     -------------------------------------------       Director
                  Stephen F. Dwyer

               /s/ DOUGLAS T. GJERDE*
     -------------------------------------------       Director
              Douglas T. Gjerde, Ph.D.

                 /s/ JEFFREY SKLAR*
     -------------------------------------------       Director
             Jeffrey Sklar, M.D., Ph.D.

               /s/ ROLAND J. SANTONI*
     -------------------------------------------       Director
                  Roland J. Santoni

                /s/ GREGORY J. DUMAN*
     -------------------------------------------       Director
                  Gregory J. Duman*

     -------------------------------------------       Director
                    Parag Saxena
</TABLE>

<TABLE>
 <S>                                                    <C>                              <C>
 *By Collin J. D'Silva, as attorney-in-fact

                 /s/ COLLIN J. D'SILVA
        --------------------------------------
                   Collin J. D'Silva
                   ATTORNEY-IN-FACT
           FOR THE INDIVIDUALS AS INDICATED.
</TABLE>

                                      II-5
<PAGE>

<TABLE>
<CAPTION>
                      SIGNATURE                                            TITLE
                      ---------                                            -----
<C>                                                    <S>
                                                    1  Form of Underwriting Agreement*
                                                       Asset Purchase Agreement between the
                                                    2  Registrant and Stephen F. Dwyer*
                                                       First Amended and Restated Certificate of
                                                  3.1  Incorporation of the Registrant
                                                  3.2  Bylaws of the Company
                                                       Form of Certificate of the Company's Common
                                                    4  Stock
                                                    5  Opinion of Kutak Rock LLP*
                                                       Warrant for Purchase of Common Stock, dated
                                                 10.1  December 16, 1997, between the Registrant and
                                                       G.S. Beckwith Gilbert
                                                       Registration Rights Agreement, dated
                                                 10.2  December 16, 1997, between the Registrant and
                                                       G.S. Beckwith Gilbert
                                                       Form of Warrant for Purchase of Common Stock
                                                 10.3  between the Registrant and various Placement
                                                       Agents and Schedule of Warrants Issued
                                                       First Amended and Restated Shareholder
                                                 10.4  Agreement, dated July 1, 1997, between the
                                                       Registrant and each holder of its Common Stock
                                                       Subscription Agreement, dated March 23, 1999,
                                                       between the Registrant and each purchaser of
                                                 10.5  Registrant's Convertible Notes due March 25,
                                                       2002, including form of Convertible Note
                                                       Second Amended and Restated 1997 Stock Option
                                                 10.6  Plan of the Registrant
                                                       1999 UK Approved Stock Option Sub Plan of the
                                                 10.7  Registrant
                                                       Employment Agreement, dated March 4, 2000,
                                                 10.8  between the Registrant and Colin J. D'Silva
                                                       Employment Agreement, dated March 4, 2000,
                                                 10.9  between the Registrant and John L. Allbery
                                                       Employment Agreement, dated March 4, 2000,
                                                10.10  between the Registrant and Douglas T. Gjerde
                                                       Employment Agreement, dated November 16, 1998,
                                                10.11  between the Registrant and William B. Walker
                                                       Letter Agreement, dated February 18, 2000,
                                                10.12  between the Registrant and Gregory J. Duman
                                                       Amended and Restated Revolving Loan Agreement,
                                                10.13  dated March 8, 2000, between the Registrant
                                                       and First National Bank of Omaha
                                                       License Agreement, dated September 1, 1994,
                                                       between Registrant and Professor Dr. Gunther
                                                10.14  Bonn, et. al. and Amendment thereto, dated
                                                       March 14, 1997+
                                                       License Agreement, dated August 20, 1997,
                                                10.15  between the Registrant and Leland Stanford
                                                       Junior University+
                                                       Supply Agreement, dated January 1, 2000,
                                                10.16  between the Registrant and Hitachi
                                                       Instruments*+
                                                       Lease Agreement, dated November 2, 1998,
                                                10.17  between the Registrant and Westlake
                                                       Development Company, Inc.
                                                       Lease Agreement, dated May 15, 1996, between
                                                10.18  Interaction Chromatography Inc. and Westlake
                                                       Development Co., Inc.
                                                   21  Subsidiaries of the Registrant
                                                 23.1  Consent of Deloitte & Touche LLP
                                                       Consent of Kutak Rock LLP (included in Exhibit
                                                 23.2  5)*
                                                   24  Powers of Attorney
                                                   27  Financial Data Schedule
</TABLE>

- ------------------------

*   To be filed by amendment.

+  Certain confidential portions of this Exhibit were omitted by means of
    redacting a portion of the text. This Exhibit has been filed separately with
    the Secretary of the Commission with the redacted text pursuant to the
    Registrant's Application Requesting Confidential Treatment under Rule 406 of
    the Securities Act.

                                      II-6

<PAGE>

                                                                     EXHIBIT 3.1

                           FIRST AMENDED AND RESTATED
                          CERTIFICATE OF INCORPORATION

                                       OF

                               TRANSGENOMIC, INC.

         Transgenomic, Inc., a corporation organized and existing under the laws
of the State of Delaware (the "Corporation") hereby certifies that:

                  (i) The Certificate of Incorporation of the Corporation was
         filed with the Secretary of State of the State of Delaware on March 6,
         1997.

                  (ii) On June 27, 1997, the incorporator of the Corporation
         adopted an amendment and restatement of the Corporation's Certificate
         of Incorporation in accordance with the provisions of Sections 241 and
         245 of the Delaware General Corporation Law.

         Accordingly, the text of the Certificate of Incorporation of the
Corporation is amended and restated in its entirety to read as follows:

                                    ARTICLE I

         The name of the Corporation is Transgenomic, Inc.

                                   ARTICLE II

         The address of the registered office of the Corporation in the State of
Delaware is Corporation Trust Center, 1209 Orange Street, City of Wilmington,
County of New Castle, Delaware 19805, and the name of its registered agent at
the address of the Corporation's registered office is The Corporation Trust
Company.

                                   ARTICLE III

         The purpose of the Corporation is to engage in any lawful act or
activity for which corporations may be organized under the General Corporation
Law of the State of Delaware.

                                   ARTICLE IV

         SECTION 4.1. The total number of shares of capital stock which the
Corporation shall have the authority to issue is 45,000,000 consisting of (a)
30,000,000 shares of Common Stock, par value $0.01 per share, and (b) 15,000,000
shares of Preferred Stock, par value $0.01 per share.

         SECTION 4.2. Each holder of a share of Common Stock shall be entitled
to one vote for each share of Common stock held of record by such holder and to
such other powers, rights and preferences as are normally available to holders
of Common Stock pursuant to the General Corporation Law of the State of
Delaware. Except as may be otherwise provided in this Restated


<PAGE>


Certificate of Incorporation or in a Preferred Stock Designation (defined in
Section 4.3), the holders of the Common Stock shall have the exclusive right to
vote for the election of directors and for all other purposes, and the holders
of Preferred Stock shall not be entitled to receive notice of any meeting of
stockholders at which they are not entitled to vote. The Common Stock shall be
subject to the express terms of the Preferred Stock and any series thereof.

         SECTION 4.3. The Preferred Stock may be issued at any time and from
time to time in one or more series. The Board of Directors is hereby authorized
to provide for the issuance of shares of Preferred Stock in series and, by
filing a certificate of designation pursuant to the applicable provisions of the
General Corporation Law of the State of Delaware (hereinafter referred to as a
"Preferred Stock Certificate of Designation"), to establish from time to time
the number of shares to be included in each such series and to fix the
designation, powers, preferences and rights of shares of each such series and
the qualifications, limitations and restrictions thereof. The authority of the
Board of Directors with respect to each such series shall include, but not be
limited to, determination of the following:

                  (a) The designation of the series, which may be by
         distinguishing number, letter or title;

                  (b) The number of shares of the series, which number the Board
         of Directors may thereafter (except where otherwise provided in the
         applicable Preferred Stock Designation) increase or decrease (but not
         below the number of shares thereof then outstanding);

                  (c) Whether dividends, if any, shall be cumulative or
         noncumulative and the dividend rate of the series;

                  (d) The date on which dividends, if any, shall be payable;

                  (e) The redemption rights and price or prices, if any, for
         shares of the series;

                  (f) The terms and amount of any sinking fund provided for the
         purchases or redemption of shares of the series;

                  (g) The amounts payable on shares of the series in the event
         of any voluntary or involuntary liquidation, dissolution or winding up
         of the affairs of the Corporation;

                  (h) Whether the shares of the series shall be convertible or
         exchangeable into shares of any other class or series, or any other
         security, of the Corporation or any other corporation, and, if so, the
         specification of such other class or series or such other security, the
         conversion or exchange price or prices or rate or rates, any
         adjustments thereof, the date or dates as of which such shares shall be
         convertible or exchangeable and all other terms and conditions upon
         which such conversion or exchange may be made;

                  (i) Restrictions on the issuance of shares of the same series
         or of any other class or series; and

                  (j) The voting rights, if any, of the holders of shares of the
         series.



                                       2
<PAGE>


         SECTION 4.4. The Corporation shall be entitled to treat the person in
whose name any share of its stock is registered as the owner thereof for all
purposes and shall not be bound to recognize any equitable or other claim to or
interest in, such share on the part of any other person, whether or not the
Corporation shall have notice thereof, except as expressly provided by
applicable law.

                                    ARTICLE V

         The Board of Directors is hereby authorized to create and issue,
whether or not in connection with the issuance and sale of any of its stock or
other securities or property, rights entitling the holders thereof to purchase
from the Corporation shares of stock or other securities of the Corporation or
any other corporation. The times at which and the terms upon which such rights
are to be issued will be determined by the Board of Directors and set forth in
the contracts or instruments that evidence such rights. The authority of the
Board of Directors with respect to such rights shall include, but not be limited
to, determination of the following:

                  (a) the initial purchase price per share or other unit of the
         stock or other securities or property to be purchased upon exercise of
         such rights;

                  (b) Provisions relating to the times at which and the
         circumstances under which such rights may be exercised or sold or
         otherwise transferred, either together with or separately from any
         other stock or other securities of the Corporation;

                  (c) Provisions which adjust the number or exercise price of
         such rights, or amount or nature of the stock or other securities or
         property receivable upon exercise of such rights, in the event of a
         combination, split or recapitalization of any stock of the Corporation,
         a change in ownership of the Corporation's stock or other securities or
         a reorganization, merger, consolidation, sale of assets or other
         occurrence relating to the Corporation or any stock of the Corporation
         and provisions restricting the ability of the Corporation to enter into
         any such transaction absent an assumption by the other party or parties
         thereto of the obligations of the Corporation under such rights;

                  (d) Provisions which deny the holder of a specified percentage
         of the outstanding stock or other securities of the Corporation the
         right to exercise such rights and/or cause the rights held by such
         holder to become void;

                  (e) Provisions which permit the Corporation to redeem such
         rights; and

                  (f) The appointment of a rights agent with respect to such
         rights.

                                   ARTICLE VI

         In furtherance and not in limitation of the powers conferred upon it by
law, the Board of Directors is expressly authorized to adopt, repeal, alter or
amend the By-laws of the Corporation by the vote of a majority of the entire
Board of Directors. In addition to any requirements of law and any other
provision of this Restated Certificate of Incorporation, the stockholders of the
Corporation may adopt, repeal, alter or amend any provision of the By-laws upon
the affirmative



                                       3
<PAGE>


vote of the holders of a majority or more of the combined voting power of the
then outstanding stock of the Corporation entitled to vote generally in the
election of directors.

                                   ARTICLE VII

         SECTION 7.1. The business and affairs of the Corporation shall be
managed by or under the direction of its Board of Directors, which may exercise
all such powers of the Corporation and do all such lawful acts and things as are
not by law or by this Restated Certificate of Incorporation directed or required
to be exercised or done by the stockholders.

         SECTION 7.2. The number of directors constituting the initial Board of
Directors shall be five and, thereafter, the number of directors shall be fixed
from time to time by resolution of the Board of Directors pursuant to the
By-laws of the Corporation, provided that the number shall at no time be less
than three or more than fifteen. The Board of Directors shall be divided into
three classes, designated Classes I, II and III, which shall be as nearly equal
in number as possible. Directors of Class I shall be elected to hold office for
a term expiring at the annual meeting of stockholders to be held in 1998;
directors of Class II shall be elected to hold office for a term expiring at the
annual meeting of stockholders to be held in 1999; and directors of Class III
shall be elected to hold office for a term expiring at the annual meeting of
stockholders to be held in 2000. At each succeeding annual meeting of
stockholders following such initial classification and election, the respective
successors of each class shall be elected for three-year terms.

         SECTION 7.3. Advance notice of nominations for elections for the
election of directors shall be given in the manner and to the extent provided in
the By-laws of the Corporation.

         SECTION 7.4. The holders of a majority of the shares then entitled to
vote at an election of directors may remove any director or the entire Board of
Directors, but only for cause.

                                  ARTICLE VIII

         SECTION 8.1. A director shall not be personally liable to the
Corporation or its stockholders for monetary damages for breach of fiduciary
duty as a director, provided that this provision shall not eliminate or limit
the liability of a director (1) for any breach of his duty of loyalty to the
Corporation or its stockholders, (2) for acts or omissions not in good faith or
which involve intentional misconduct or a knowing violation of the law, (3)
under Section 174 of the General Corporation Law of the State of Delaware or (4)
for any transaction from which the director derives an improper personal
benefit. If the General Corporation Law of the State of Delaware is amended
after the filing of this Restated Certificate of Incorporation to authorize
corporate action further eliminating or limiting the personal liability of
directors, then the liability of a director of the Corporation shall be
eliminated or limited to the fullest extent permitted by the General Corporation
Law of the State of Delaware, as so amended.

         SECTION 8.2. Any repeal or modification of the foregoing paragraph by
the stockholders of the Corporation shall not adversely affect any right or
protection of a director or the Corporation existing at the time of such repeal
or modification.

                                   ARTICLE IX



                                       4
<PAGE>


         SECTION 9.1. Each person who was or is made a party or is threatened to
be made a party to or is otherwise involved in any action, suit or proceeding,
whether civil, criminal, administrative or investigative (hereinafter a
"proceeding"), by reason of the fact that he or she, or a person of whom he or
she is the legal representative, is or was a director or officer of the
Corporation or is or was serving at the request of the Corporation as a director
or officer of another corporation or of a partnership, joint venture, trust or
other enterprise, including service with respect to an employee benefit plan
(hereinafter an "indemnitee"), whether the basis of such proceeding is alleged
action or omission in an official capacity as a director or officer or in any
other capacity while serving as a director or officer, shall be indemnified and
held harmless by the Corporation to the fullest extent authorized by the General
Corporation Law of the State of Delaware, as the same exists or may hereafter be
amended (but, in the case of any such amendment, only to the extent that such
amendment permits the Corporation to provide broader indemnification rights than
permitted prior thereto), against all expense, liability and loss (including,
without limitation, attorneys' fees, judgments, fines, excise taxes or penalties
and amounts paid or to be paid in settlement) incurred or suffered by such
indemnitee in connection therewith, and such indemnification shall continue with
respect to an indemnitee who has ceased to be a director or officer and shall
inure to the benefit of the indemnitee's heirs, executors and administrators;
provided, however, that, except as provided in Section 9.2 with respect to
proceedings to enforce rights to indemnification, the Corporation shall
indemnify any such indemnitee in connection with a proceeding initiated by such
indemnitee only if such proceeding was authorized by the Board of Directors of
the Corporation. The right to indemnification conferred in this Article IX shall
be a contract right and shall include the right to be paid by the Corporation
the expenses incurred in defending any such proceeding in advance of its final
disposition (hereinafter an "advancement of expenses"); provided, further, that,
if required by the General Corporation Law of the State of Delaware, an
advancement of expenses incurred by an indemnitee shall be made only upon
delivery to the Corporation of an undertaking (hereinafter, an "undertaking"),
by or on behalf of such indemnitee, to repay all amounts so advanced if it shall
ultimately be determined by final judicial decision from which there is no
further right to appeal (hereinafter, a "final adjudication") that such
indemnitee is not entitled to be indemnified for such expenses under this
Article IX or otherwise.

         SECTION 9.2. If a claim under Section 9.1 is not paid in full by the
Corporation within 60 days after a written claim has been received by the
Corporation (except in the case of a claim for an advancement of expenses, in
which case the applicable period shall be 20 days), the indemnitee may at any
time thereafter bring suit against the Corporation to recover the unpaid amount
of the claim. If successful in whole or in part in any such suit, the indemnitee
shall also be entitled to be paid the expense of prosecuting or defending such
suit. In (i) any suit brought by the indemnitee to enforce a right to
indemnification hereunder (but not in a suit brought by the indemnitee to
enforce a right to an advancement of expenses), it shall be a defense that, and
(ii) in any suit brought by the Corporation to recover an advancement of
expenses pursuant to the terms of an undertaking, the Corporation shall be
entitled to recover such expenses upon a final adjudication that, the indemnitee
has not met the applicable standard of conduct set forth in the General
Corporation Law of the State of Delaware. Neither the failure of the Corporation
(including its Board of Directors, independent legal counsel or its
stockholders) to have made a determination prior to the commencement of such
suit that indemnification of the indemnitee is proper in the circumstances
because the indemnitee has met the applicable standard of conduct set forth in
the General Corporation Law of the State of Delaware nor an actual determination
by



                                       5
<PAGE>


the Corporation (including its Board of Directors, independent legal counsel, or
its stockholders) that the indemnitee has not met the applicable standard of
conduct shall create a presumption that the indemnitee has not met the
applicable standard of conduct or, in the case of such a suit brought by the
indemnitee, be a defense to such suit. In any suit brought by the indemnitee to
enforce a right to indemnification or to an advancement of expenses hereunder or
by the Corporation to recover an advancement of expenses pursuant to the terms
of an undertaking, the burden of proving that the indemnitee is not entitled
under this Article IX or otherwise to be indemnified, or to such advancement of
expenses, shall be on the Corporation.

         SECTION 9.3. The rights to indemnification and to the advancement of
expenses conferred in this Article IX shall not be exclusive of any other right
which any person may have or hereafter acquire under this Restated Certificate
of Incorporation or any bylaw, contract, agreement, vote of stockholders or
disinterested directors or otherwise.

         SECTION 9.4. The Corporation may maintain insurance, at its expense, to
protect itself and any indemnitee against any expense, liability or loss,
whether or not the Corporation would have the power to indemnify such person
against such expense, liability or loss under the General Corporation Law of the
State of Delaware.

         SECTION 9.5. The Corporation may, to the extent authorized from time to
time by the Board of Directors, grant rights to indemnification and to the
advancement of expenses to any employee or agent of the Corporation to the
fullest extent of the provisions of this Article IX or as otherwise permitted
under the General Corporation Law of the State of Delaware with respect to the
indemnification and advancement of expenses of directors and officers of the
Corporation.

                                    ARTICLE X

         A director of the Corporation, in determining what he reasonably
believes to be in the best interests of the Corporation, shall consider the
interests of the Corporation's stockholders and, in his discretion, may consider
any of the following:

                  (a) The interests of the Corporation's employees, independent
         contractors, agents, suppliers, creditors and customers;

                  (b) The economy of the nation;

                  (c) Community and societal interests; and

                  (d) The long-term as well as short-term interests of the
         Corporation and its stockholders, including the possibility that these
         interests may be best served by the continued independence of the
         Corporation.

                                   ARTICLE XI

         Election of directors at an annual or special meeting of stockholders
need not be by written ballot unless the By-laws of the Corporation shall so
provide.

                                   ARTICLE XII



                                       6
<PAGE>


         Cumulative voting for the election of directors shall not be permitted.

                                  ARTICLE XIII

         Any action required or permitted to be taken by the stockholders of the
Corporation must be effected at a duly called annual or special meeting of
stockholders of the Corporation, and the ability of the stockholders to consent
in writing to the taking of any action is hereby specifically denied. The
foregoing sentence shall take effect on the day following the date on which the
Corporation first has more than 35 stockholders of record. Except as otherwise
required by law, special meetings of stockholders of the Corporation may be
called only by the Chairman of the Board, the Board of Directors pursuant to a
resolution approved by a majority of the entire Board of Directors, by the Chief
Executive Officer if one is appointed, otherwise by the President or as
otherwise provided in the By-laws of the Corporation.

                                   ARTICLE XIV

         The vote of stockholders of the Corporation required to approve
Business Combinations (as hereinafter defined) shall be as set forth in this
Article XIV.

         SECTION 14.1. In addition to any affirmative vote required by law or by
this Restated Certificate of Incorporation, and except as otherwise expressly
provided in Section 14.3 of this Article XIV:

                  (a) any merger or consolidation of the Corporation with (1)
         any Interested Stockholder or (2) any other corporation (whether or not
         itself an Interested Stockholder) which is, or after such merger or
         consolidation would be, an Affiliate or Associate of an Interested
         Stockholder;

                  (b) any sale, lease, exchange, mortgage, pledge, transfer or
         other disposition (in one transaction or a series of transactions) to
         or with any Interested Stockholder or any Affiliate or Associate of any
         Interested Stockholder of (1) all or substantially all the assets of
         the Corporation or (2) assets of the Corporation or any of its
         Subsidiaries representing in the aggregate more than 75% of the total
         value of the assets of the Corporation and its consolidated
         Subsidiaries as reflected on the most recent consolidated balance sheet
         of the Corporation and its consolidated Subsidiaries prepared in
         accordance with generally accepted accounting principles then in
         effect;

                  (c) any sale, lease, exchange, mortgage, pledge, transfer or
         other disposition (in one transaction or a series of transactions) to
         or with any Interested Stockholder or any Affiliate or Associate of any
         Interested Stockholder of any assets of the Corporation or of any
         Subsidiary having an aggregate Fair Market Value of $10,000,000 or
         more, but less than the amount referred to in clause (ii) of paragraph
         (b) of this Section 14.1 or (ii) any merger or consolidation of any
         Subsidiary of the Corporation having assets with an aggregate Fair
         Market Value of $10,000,000 or more in a transaction not covered by
         paragraph (b) of this Section 14.1 with (x) any Interested Stockholder
         or (y) any other corporation (whether or not itself an Interested
         Stockholder) which is, or after such merger or consolidation would be,
         an Affiliate or Associate of an Interested Stockholder;



                                       7
<PAGE>


                  (d) the issuance or transfer by the Corporation or any
         Subsidiary (in one transaction or a series of transactions) to any
         Interested Stockholder or any Affiliate or Associate of any Interested
         Stockholder of any securities of the Corporation or any Subsidiary in
         exchange for cash, securities or other property (or a combination
         thereof) having an aggregate Fair Market Value of $10,000,000 or more,
         other than the issuance of securities upon the conversion of
         convertible securities of the Corporation or any Subsidiary which were
         not acquired by such Interested Stockholder (or such Affiliate or
         Associate) from the Corporation or a Subsidiary;

                  (e) The adoption of any plan or proposal for the liquidation
         or dissolution of the Corporation proposed by or on behalf of any
         Interested Stockholder or any Affiliate or Associate of any Interested
         Stockholder; or

                  (f) any reclassification of securities (including any reverse
         stock split) or recapitalization of the Corporation, or any merger or
         consolidation of the Corporation with any of its Subsidiaries or any
         other transaction (whether or not with or into or otherwise involving
         any Interested Stockholder), which in any such case has the effect,
         directly or indirectly, of increasing the proportionate share of the
         outstanding shares of any class or series of stock or securities
         convertible into stock of the Corporation or any Subsidiary which is
         directly or indirectly beneficially owned by any Interested Stockholder
         or any Affiliate or Associate of any Interested Stockholder

shall not be consummated without (5) the affirmative vote of the holders of at
least 75% of the combined voting power of the then outstanding shares of stock
of all classes and series of the Corporation entitled to vote generally in the
election of directors (the "Voting Stock") and (6) the affirmative vote of a
majority of the combined voting power of the then outstanding shares of Voting
Stock held by Disinterested Stockholders, in each case voting together as a
single class. Such affirmative vote shall be required notwithstanding the fact
that no vote may be required, or that a lesser percentage may be specified, by
law or by this Restated Certificate of Incorporation or by a registered
securities association or in any agreement with any national securities exchange
or otherwise.

         SECTION 14.2. The term "Business Combination" as used in this Article
XIV shall mean any transaction which is referred to in any one or more of
paragraphs (a) through (f) of Section 14.1 of this Article XIV.

         SECTION 14.3. The provisions of Section 14.1 shall not be applicable to
any particular Business Combination, and such Business Combination shall require
only such affirmative vote as is required by law and any other provision of this
Restated Certificate of Incorporation, if all the conditions specified in any of
the following paragraphs (a), (b) or (c) are met:

(a) such Business Combination shall have been approved by a majority of the
Disinterested Directors and (ii) the Interested Stockholder involved in such
Business Combination (x) acquired such status as an Interested Stockholder in a
manner substantially consistent with an agreement or memorandum of understanding
approved by the Board of Directors (including a majority of the Disinterested
Directors) prior to the time such Interested Stockholder became an Interested



                                       8
<PAGE>


Stockholder and (y) has complied with all requirements imposed by such agreement
or memorandum of understanding; or

                  (b) in the case of any Business Combination described in
         paragraph (a) or (f) of Section 14.1, (i) such Business Combination
         shall have been approved by a majority of the Disinterested Directors,
         (ii) such Business Combination shall not have resulted, directly or
         indirectly, in an increase of more than 10% in the total amount of
         shares of any class or series of stock or securities convertible into
         stock of the Corporation or any Subsidiary which was directly or
         indirectly beneficially owned by an Interested Stockholder and all
         Affiliates and Associates of such Interested Stockholder at the time of
         the approval of such Business Combination by a majority of the
         Disinterested Directors and (iii) such Business Combination shall not
         have been consummated within a period of two years after the
         consummation of any other Business Combination described in paragraph
         (a), (b), (c), (d), (e) or (f) of Section 14.1 (whether or not such
         other Business Combination shall have been approved by a majority of
         the Disinterested Directors) which had the effect, directly or
         indirectly, of increasing the proportionate share of the outstanding
         shares of any class or series of stock or securities convertible into
         stock of the Corporation or any Subsidiary which was directly or
         indirectly beneficially owned by such Interested Stockholder or any
         Affiliate or Associate of such Interested Stockholder; or

                  (c) in the case of any Business Combination described in
         paragraph (c) or (d) of Section 14.1, such Business Combination shall
         have been approved by a majority of the Disinterested Directors.

         SECTION 14.4.  For the purposes of this Article XIV:

                  (a) A "PERSON" shall mean any individual, group, firm,
         corporation, partnership, trust or other entity.

                  (b) "INTERESTED STOCKHOLDER" shall mean any person (other than
         the Corporation, any Subsidiary and other than any group consisting of
         the directors and officers of the Corporation which may be deemed to be
         a group solely by reason of each of them being directors or officers of
         the Corporation or members of a slate proposed by the Corporation as
         directors) who or which:

                                    (1) is the beneficial owner, directly or
                  indirectly, of 10% or more of the combined voting power of the
                  then outstanding shares of Voting Stock; or

                                    (2) is an Affiliate of the Corporation and
                  at any time within the two-year period immediately prior to
                  the date in question was the beneficial owner, directly or
                  indirectly, of 10% or more of the combined voting power of the
                  then outstanding shares of Voting Stock; or

                                    (3) is an assignee of or has otherwise
                  succeeded to the beneficial ownership of any shares of Voting
                  Stock which were at any time within the two-year period
                  immediately prior to the date in question beneficially owned
                  by any Interested Stockholder, if such assignment or
                  succession shall have



                                       9
<PAGE>


                  occurred in the course of a transaction or series of
                  transactions not involving a public offering within the
                  meaning of the Securities Act of 1933.

                  (c) "DISINTERESTED STOCKHOLDER" shall mean a stockholder of
         the Corporation who is not an Interested Stockholder or an Affiliate or
         an Associate of an Interested Stockholder.

                  (d) a person shall be a "BENEFICIAL OWNER" of any Voting
         Stock:

                                    (1) which such person or any of its
                  Affiliates or Associates  beneficially owns, directly or
                  indirectly; or

                                    (2) which such person or any of its
                  Affiliates or Associates has (a) the right to acquire (whether
                  such right is exercisable immediately or only after the
                  passage of time) pursuant to any agreement, arrangement or
                  understanding or upon the exercise of conversion rights,
                  exchange rights, warrants or options, or otherwise or (b) the
                  right to vote or to direct the vote pursuant to any agreement,
                  arrangement or understanding; or

                                    (3) which are beneficially owned, directly
                  or indirectly, by any other person with which such person or
                  any of its Affiliates or Associates has any agreement,
                  arrangement or understanding for the purpose of acquiring,
                  holding, voting or disposing of any shares of Voting Stock.

                  (e) For the purposes of determining whether a person is an
         Interested Stockholder pursuant to paragraph (b) of this Section 14.4,
         the number of shares of Voting Stock deemed to be outstanding shall
         include shares deemed owned by such person through application of
         paragraph (d) of this Section 14.4 but shall not include any other
         shares of Voting Stock which may be issuable to other persons pursuant
         to any agreement, arrangement or understanding or upon exercise of
         conversion rights, exchange rights, warrants or options or otherwise.

                  (f) "AFFILIATE" and "ASSOCIATE" shall have the respective
         meanings ascribed to such terms in Rule 12b-2 of the General Rules and
         Regulations under the Securities Exchange Act of 1934, as in effect on
         February 1, 1993.

                  (g) "SUBSIDIARY" shall mean any Corporation more than 50% of
         whose outstanding stock having ordinary voting power in the election of
         directors is owned by the Corporation, by a Subsidiary or by the
         Corporation and one or more Subsidiaries; provided, however, that for
         the purposes of the definition of Interested Stockholder set forth in
         paragraph (b) of this Section 14.4, the term "Subsidiary" shall mean
         only a corporation of which a majority of each class of equity security
         is owned by the Corporation, by a Subsidiary or by the Corporation and
         one or more Subsidiaries.

                  (h) "DISINTERESTED DIRECTOR" means any member of the Board of
         Directors of the Corporation who is unaffiliated with, and not a
         nominee of, the Interested Stockholder and was a member of the Board of
         Directors prior to the time that the Interested Stockholder became an
         Interested Stockholder, and any successor of a Disinterested Director
         who is



                                       10
<PAGE>


         unaffiliated with, and not a nominee of, the Interested Stockholder and
         who is recommended to succeed a Disinterested Director by a majority of
         Disinterested Directors then on the Board of Directors.

                  (i) "FAIR MARKET VALUE" means: (1) in the case of stock, the
         highest closing sale price during the 30-day period immediately
         preceding the date in question of a share of such stock on the New York
         Stock Exchange Composite Tape or, if such stock is not quoted on the
         Composite Tape, on the New York Stock Exchange or, if such stock is not
         listed on such Exchange, on the principal United States securities
         exchange registered under the Securities Exchange Act of 1934 on which
         such stock is listed or, if such stock is not listed on any such
         exchange, the highest closing sales price or bid quotation with respect
         to a share of such stock during the 30-day period preceding the date in
         question on the Nasdaq Stock Market or, if no such quotations are
         available, the fair market value on the date in question of a share of
         such stock as determined by a majority of the Disinterested Directors
         in good faith; and (2) in the case of stock of any class or series
         which is not traded on any securities exchange or in the
         over-the-counter market or in the case of property other than cash or
         stock, the fair market value of such stock or property, as the case may
         be, on the date in question as determined by a majority of the
         Disinterested Directors in good faith.

         SECTION 14.5. A majority of the Disinterested Directors of the
Corporation shall have the power and duty to determine, on the basis of
information known to them after reasonable inquiry, all facts necessary to
determine compliance with this Article XIV, including, without limitation, (a)
whether a person is an Interested Stockholder, (b) the number of shares of
Voting Stock beneficially owned by any person, (c) whether a person is an
Affiliate or Associate of another person, (d) whether the requirements of
Section 14.3 have been met with respect to any Business Combination and (e)
whether the assets which are the subject of any Business Combination have, or
the consideration to be received for the issuance or transfer of securities by
the Corporation or any Subsidiary in any Business Combination has, (i) an
aggregate Fair Market Value of $10,000,000 or more or (ii) represent in the
aggregate more than 75% of the total value of the assets of the Corporation and
its consolidated Subsidiaries prepared in accordance with generally accepted
accounting principles then in effect; and the good faith determination of a
majority of the Disinterested Directors on such matters shall be conclusive and
binding for all purposes of this Article XIV.

         SECTION 14.6. Nothing contained in this Article XIV shall be construed
to relieve an Interested Stockholder from any fiduciary obligation imposed by
law.

                                   ARTICLE XV

         The Corporation reserves the right at any time and from time to time to
amend, alter, change or repeal any provision contained in this Restated
Certificate of Incorporation, and any other provisions authorized by the laws of
the State of Delaware at the time in force may be added or inserted, in the
manner now or hereafter prescribed herein or by applicable law, and all rights,
preferences and privileges of whatsoever nature conferred upon stockholders,
directors or any other persons whomsoever by and pursuant to this Restated
Certificate of Incorporation in its present form or as hereafter amended are
granted subject to the right reserved in this Article XV;



                                       11
<PAGE>


provided, however, that any amendment or repeal of Article VIII or Article IX of
this Restated Certificate of Incorporation shall not adversely affect any right
or protection existing hereunder immediately prior to such amendment or repeal;
and provided, further, that Articles V, VI, VII, VIII, IX, X, XII, XIII, XIV and
XV of this Restated Certificate of Incorporation shall not be amended, altered,
changed or repealed without the affirmative vote of the holders of at least a
majority of the then outstanding stock of the Corporation entitled to vote
generally in the election of directors."



                                       12
<PAGE>


         IN WITNESS WHEREOF, this Restated Certificate of Incorporation has been
signed this 27 day of June, 1997.
           ----



                                     TRANSGENOMIC, INC.



                                     /s/ P. Thomas Pogge
                                     -------------------------------------------
                                     P. Thomas Pogge, Incorporator

STATE OF NEBRASKA )
                  ) ss.
COUNTY OF DOUGLAS )


         Before me, a notary public, on this day personally appeared P. Thomas
Pogge, known to me to be the person whose name is subscribed in the foregoing
document, and, being by me first duly sworn, declared that the statements
therein contained are true and correct.

         Given under my hand and seal of office this 27 day of June, 1997.
                                                     --

    [SEAL]                           /s/ Steven P. Amen
                                     -------------------------------------------
                                     Notary Public


                                      13


<PAGE>

                                                                     EXHIBIT 3.2







                                    BYLAWS OF

                               TRANSGENOMIC, INC.











<PAGE>



                                TABLE OF CONTENTS

<TABLE>
<CAPTION>

                                                                                                                PAGE
<S>                   <C>                                                                                         <C>

                                    ARTICLE I

                                  STOCKHOLDERS

Section 1.            Time and Place of Meetings..................................................................1
Section 2.            Annual Meetings.............................................................................1
Section 3.            Special Meetings............................................................................1
Section 4.            Notice of Meetings..........................................................................1
Section 5.            Quorum and Adjournment......................................................................2
Section 6.            Voting......................................................................................2
Section 7.            Stockholder Proposals and Nominations of Directors..........................................2
Section 8.            Inspectors of Elections.....................................................................3
Section 9.            Opening and Closing of Polls................................................................4
Section 10.           Participation in Meetings by Conference Telephone...........................................4

                                   ARTICLE II

                                    DIRECTORS

Section 1.            General Powers..............................................................................4
Section 2.            Number of Directors; Removal; Qualifications................................................4
Section 3.            Vacancies...................................................................................5
Section 4.            Regular Meetings............................................................................5
Section 5.            Special Meetings............................................................................5
Section 6.            Quorum......................................................................................5
Section 7.            Written Action..............................................................................6
Section 8.            Participation in Meetings by Conference Telephone...........................................6
Section 9.            Committees..................................................................................6
Section 10.           Compensation................................................................................7
Section 11.           Regulations; Manner of Acting...............................................................7

                                   ARTICLE III

                                     NOTICES

Section 1.            Generally...................................................................................7
Section 2.            Waivers.....................................................................................7



                                       1
<PAGE>


                                   ARTICLE IV

                                    OFFICERS

Section 1.            Generally...................................................................................8
Section 2.            Compensation................................................................................8
Section 3.            Election....................................................................................8
Section 4.            Authority and Duties........................................................................8
Section 5.            Removal and Resignation; Vacancies..........................................................8
Section 6.            Chairman....................................................................................8
Section 7.            President/Chief Executive Officer...........................................................9
Section 7A.           Chief Operating Officer.....................................................................9
Section 8.            Execution of Documents and Action With Respect to Securities of Other Corporations..........9
Section 9.            Vice President..............................................................................9
Section 10.           Secretary and Assistant Secretaries.........................................................9
Section 11.           Treasurer and Assistant Treasurers.........................................................10

                                    ARTICLE V

                                 INDEMNIFICATION

Section 1.            Right to Indemnification...................................................................10
Section 2.            Right of Indemnitee To Bring Suit..........................................................11
Section 3.            Nonexclusivity of Rights...................................................................12
Section 4.            Insurance..................................................................................12
Section 5.            Indemnification of Agents of the Corporation...............................................12
Section 6.            Indemnification Contracts..................................................................12
Section 7.            Effect of Amendment........................................................................12

                                   ARTICLE VI

                                      STOCK

Section 1.            Certificates...............................................................................12
Section 2.            Transfer...................................................................................13
Section 3.            Lost, Stolen or Destroyed Certificates.....................................................13
Section 4.            Record Date................................................................................13



                                       2
<PAGE>


                                   ARTICLE VII

                               GENERAL PROVISIONS

Section 1.            Fiscal Year................................................................................14
Section 2.            Corporate Seal.............................................................................14
Section 3.            Reliance Upon Books, Reports and Records...................................................14
Section 4.            Time Periods...............................................................................14
Section 5.            Dividends..................................................................................14
</TABLE>

                                  ARTICLE VIII

AMENDMENT OF BYLAWS        14



                                       3
<PAGE>



                                     BYLAWS

                                    ARTICLE I

                                  STOCKHOLDERS

         Section 1. TIME AND PLACE OF MEETINGS. All meetings of the stockholders
for the election of directors or for any other purpose shall be held at such
time and place, within or without the State of Delaware, as may be designated by
the Board of Directors, or by the Chairman of the Board, the Chief Executive
Officer, the President or the Secretary in the absence of a designation by the
Board of Directors, and stated in the notice of the meeting or in a duly
executed waiver of notice thereof. [Sections 211(a), (b).](1)

         Section 2. ANNUAL MEETINGS. An annual meeting of the stockholders shall
be held on such date and at such time as shall be designated by the Board of
Directors, at which meeting the stockholders shall elect by a plurality vote the
directors to succeed those whose terms expire at that meeting and shall transact
such other business as may properly be brought before the meeting.

         Section 3. SPECIAL MEETINGS. Special meetings of the stockholders, for
any purpose or purposes, unless otherwise prescribed by statute or by the
Certificate of Incorporation, may only be called (i) by the Chairman of the
Board, (ii) by the Board of Directors pursuant to a resolution adopted by a
majority of the entire Board of Directors or (iii) by the Chief Executive
Officer, if one is appointed, otherwise the President. [Section 211(d).]

         Section 4. NOTICE OF MEETINGS. Written notice of every meeting of the
stockholders, stating the place, date and hour of the meeting and, in the case
of a special meeting, the purpose or purposes for which the meeting is called,
shall be given not less than 10 nor more than 60 days before the date of the
meeting to each stockholder entitled to vote at such meeting, except as
otherwise provided herein or by law. When a meeting is adjourned to another
place, date or time, written notice need not be given of the adjourned meeting
if the place, date and time thereof are announced at the meeting at which the
adjournment is taken; provided, however, that if the adjournment is for more
than 30 days, or if after the adjournment a new record date is fixed for the
adjourned meeting, written notice of the place, date and time of the adjourned
meeting shall be given in conformity herewith. At any adjourned meeting, any
business may be transacted which might have been transacted at the original
meeting. [Section 222.]

         Section 5. QUORUM AND ADJOURNMENT. The holders of a majority of the
stock issued and outstanding and entitled to vote thereat, present in person or
represented by proxy, shall constitute a quorum at all meetings of the
stockholders for the transaction of business except as otherwise provided by law
or by the Certificate of Incorporation. If, however, such quorum shall not be
present or represented at any meeting of the stockholders, the stockholders
entitled to vote thereat, present in person or represented by proxy, shall have
power to adjourn the meeting from

- --------------------------
(1) Citations are to the General Corporation Law of the State of Delaware as in
effect on January 1, 1997 and are inserted for reference only, and do not
constitute a part of the Bylaws.


                                       1
<PAGE>


time to time, without notice other than announcement at the meeting, until a
quorum shall be present or represented; provided, however, that if the
adjournment is for more than 30 days, or if after the adjournment a new record
date is fixed for the adjourned meeting, a notice of the adjourned meeting,
conforming to the requirements of Section 4 of Article I hereof, shall be given
to each stockholder of record entitled to vote at such meeting. At any adjourned
meeting at which a quorum is present, any business may be transacted that might
have been transacted on the original date of the meeting. [Sections 216,
222(c).]

         Section 6. VOTING. Except as otherwise provided by law or by the
Certificate of Incorporation, each stockholder shall be entitled at every
meeting of the stockholders to one vote for each share of stock having voting
power standing in the name of such stockholder on the books of the Corporation
on the record date for the meeting, and such votes may be cast either in person
or by written proxy. Every proxy must be duly executed and filed with the
Secretary of the Corporation. A stockholder may revoke any proxy which is not
irrevocable by attending the meeting and voting in person or by filing an
instrument in writing revoking the proxy or another duly executed proxy bearing
a later date with the Secretary of the Corporation. No vote of the stockholders
need be taken by written ballot unless otherwise required by law. Any vote which
need not be taken by ballot may be conducted in any manner approved by the
meeting. Every vote taken by written ballot shall be counted by one or more
inspectors of election appointed by the Board of Directors. When a quorum is
present at any meeting, the vote of the holders of a majority of the stock which
has voting power present in person or represented by proxy shall decide any
question properly brought before such meeting, unless the question is one upon
which by express provision of law, the Certificate of Incorporation or these
Bylaws, a different vote is required, in which case such express provision shall
govern and control the decision of such question. [Sections 212, 216.]

         Section 7. STOCKHOLDER PROPOSALS AND NOMINATIONS OF DIRECTORS.
Nominations for election to the Board of Directors of the Corporation at a
meeting of the stockholders may be made by the Board of Directors, or on behalf
of the Board of Directors by a Nominating Committee appointed by the Board of
Directors, or by any stockholder of the Corporation entitled to vote for the
election of directors at such meeting. Any nominations, other than those made by
or on behalf of the Board of Directors, and any proposal by any stockholder to
transact any corporate business at an annual or special stockholders meeting,
shall be made by notice in writing and mailed by certified mail to the Secretary
of the Corporation and (i) in the case of an annual meeting, received no later
than 35 days prior to the date of the annual meeting; provided, however, that if
less than 35 days' notice of a meeting of stockholders is given to the
stockholders, such notice of proposed business or nomination by such stockholder
shall have been made or delivered to the Secretary of the Corporation not later
than the close of business on the seventh day following the day on which the
notice of a meeting was mailed, and (ii) in the case of a special meeting of
stockholders, received not later than the close of business on the tenth day
following the day on which notice of the date of the meeting was mailed. A
notice of nominations by stockholders shall set forth as to each proposed
nominee who is not an incumbent director (i) the name, age, address and
principal occupation of each nominee proposed in such notice, (ii) the number of
shares of stock of the Corporation which are beneficially owned by each such
nominee and the nominating stockholder and (iii) any other information
concerning the nominee that must be disclosed regarding nominees in proxy
solicitations



                                       2
<PAGE>


pursuant to Section 14(a) of the Securities Exchange Act of 1934, as amended,
and the rules under such section.

         The Chairman of the Board, or in his absence the Chief Executive
Officer, if one is appointed, otherwise the President or the Secretary, may, if
the facts warrant, determine and declare to the meeting of stockholders that a
nomination was not made in accordance with the foregoing procedure and that the
defective nomination shall be disregarded.

         Section 8. INSPECTORS OF ELECTIONS. Preceding any meeting of the
stockholders, the Board of Directors may appoint one or more persons to act as
Inspectors of Elections and may designate one or more alternate inspectors. In
the event either no inspector or alternate is appointed or no inspector or
alternate is able to act, the Secretary shall serve as the inspector or the
person presiding at the meeting shall appoint one or more inspectors to act at
the meeting. Each inspector, before entering upon the discharge of the duties of
an inspector, shall take and sign an oath faithfully to execute the duties of
inspector with strict impartiality and according to the best of his or her
ability. The inspector shall:

                  (a) ascertain the number of shares outstanding and the voting
         power of each;

                  (b) determine the shares represented at a meeting and the
         validity of proxies and ballots;

                  (c) count all votes and ballots;

                  (d) determine and retain for a reasonable period a record of
         the disposition of any challenges made to any determination by the
         inspectors; and

                  (e) certify his or her determination of the number of shares
         represented at the meeting and his or her count of all votes and
         ballots.

         The inspector may appoint or retain other persons or entities to assist
in the performance of the duties of inspector.

         When determining the shares represented and the validity of proxies and
ballots, the inspector shall be limited to an examination of the proxies, any
envelopes submitted with those proxies, ballots and the regular books and
records of the Corporation. The inspector may consider reliable information for
the limited purpose of reconciling proxies and ballots submitted by or on behalf
of banks, brokers or their nominees or a similar person which represent more
votes than the holders of a proxy is authorized by the record owner to cast or
more votes than the stockholder holds of record. If the inspector considers
other reliable information as outlined in this Section, the inspector, at the
time of his or her certification pursuant to (e) of this Section, shall specify
the precise information considered, the person or persons from whom the
information was obtained, when this information was obtained, the means by which
the information was obtained, and the basis for the inspector's belief that such
information is accurate and reliable. [Sections 231(a), (b), (d).]

         Section 9. OPENING AND CLOSING OF POLLS. The date and time for the
opening and the closing of the polls for each matter to be voted upon at a
meeting of stockholders shall be



                                       3
<PAGE>


announced at the meeting. The inspector of the election shall be prohibited from
accepting any ballots, proxies or votes nor any revocations thereof or changes
thereto after the closing of the polls, unless the Court of Chancery upon
application by a stockholder shall determine otherwise. [Section 231(c).]

         Section 10. PARTICIPATION IN MEETINGS BY CONFERENCE TELEPHONE. So long
as the Corporation has 35 or fewer stockholders, any stockholder may participate
in any meeting of stockholders by conference telephone or similar communications
equipment by means of which all persons participating in the meeting can hear
each other, and such participation shall constitute presence in person at the
meeting.

                                   ARTICLE II

                                    DIRECTORS

         Section 1. GENERAL POWERS. The business and affairs of the Corporation
shall be managed by or under the direction of its Board of Directors, which may
exercise all such powers of the Corporation and do all such lawful acts and
things as are not by law or by the Certificate of Incorporation directed or
required to be exercised or done by the stockholders. [Section 141(a).]

         Section 2. NUMBER OF DIRECTORS; REMOVAL; QUALIFICATIONS. (a) The number
of directors constituting the initial Board of Directors shall be five and,
thereafter, the number of directors shall be fixed from time to time by
resolution of the Board of Directors; provided that the number shall at no time
be less than three or more than fifteen. In case of any increase in the number
of directors in advance of an annual meeting of stockholders, each additional
director shall be elected by the directors then in office, although less than a
quorum, to hold office until the next annual meeting of shareholders or until
his successor is elected. No decrease in the number of directors shall shorten
the term of any incumbent director.

         (b) The Board of Directors shall be divided into three classes,
designated Classes I, II and III, which shall be as nearly equal in number as
possible. Directors of Class I shall be elected to hold office for a term
expiring at the annual meeting of stockholders to be held in 1998; directors of
Class II shall be elected to hold office for a term expiring at the annual
meeting of stockholders to be held in 1999; and directors of Class III shall be
elected to hold office for a term expiring at the annual meeting of stockholders
to be held in 2000. At each succeeding annual meeting of stockholders following
such initial classification and election, the respective successors of each
class shall be elected for three-year terms.

         (c) After the election or appointment of a director, the holders of a
majority of the shares then entitled to vote generally for the election of
directors may remove such director or the entire Board of Directors, but only
for cause.

         (d) At any time securities of the Corporation are registered under
Section 12 of the Securities Exchange Act of 1934, as amended, no less than two
directors shall be persons other than (i) officers or employees of the
Corporation or it subsidiaries or (ii) individuals having a relationship which,
in the opinion of the Board of Directors, would interfere with the exercise of



                                       4
<PAGE>


independent judgment in carrying out the responsibilities of a director.
Directors need not be shareholders of the Corporation. [Sections 141(b), (k).]

         Section 3. VACANCIES. Vacancies in the Board of Directors resulting
from death, resignation, retirement, disqualification, removal from office or
other cause, and newly created directorships resulting from any increase in the
authorized number of directors, may be filled only by the affirmative vote of a
majority of the remaining directors, though less than a quorum of the Board of
Directors, and directors so chosen shall hold office until the next annual
meeting of shareholders or until their successors shall have been duly elected
and qualified. [Section 223.]

         Section 4. REGULAR MEETINGS. Regular meetings of the Board of Directors
may be held without notice immediately after the annual meeting of the
stockholders and at such other times and places as shall from time to time be
determined by the Board of Directors. [Section 141(g).]

         Section 5. SPECIAL MEETINGS. Special meetings of the Board of Directors
may be called by the Chairman of the Board or the Chief Executive Officer, if
one is appointed, otherwise the President or the Secretary on five days' written
notice to each director by whom such notice is not waived, given either
personally or by courier, mail, facsimile transmission or telegram, and shall be
called by the Chief Executive Officer, President or the Secretary in like manner
and on like notice on the written request of any two directors. [Section
141(g).]

         Section 6. QUORUM. At all meetings of the Board of Directors, a
majority of the total number of directors then in office shall constitute a
quorum for the transaction of business, and the act of a majority of the
directors present at any meeting at which there is a quorum shall be the act of
the Board of Directors. If a quorum shall not be present at any meeting of the
Board of Directors, the Directors present thereat may adjourn the meeting from
time to time to another place, time or date, without notice other than
announcement at the meeting, until a quorum shall be present. [Section 141(b).]

         Section 7. WRITTEN ACTION. Any action required or permitted to be taken
at any meeting of the Board of Directors or of any committee thereof may be
taken without a meeting if all members of the Board or such committee, as the
case may be, consent thereto in writing and the writing or writings are filed
with the minutes or proceedings of the Board or such committee. [Section
141(f).]

         Section 8. PARTICIPATION IN MEETINGS BY CONFERENCE TELEPHONE. Members
of the Board of Directors, or any committee designated by the Board of
Directors, may participate in a meeting of the Board of Directors, or any such
committee, by means of conference telephone or similar communications equipment
by means of which all persons participating in the meeting can hear each other,
and such participation in a meeting shall constitute presence in person at the
meeting. [Section 141(i).]

         Section 9. COMMITTEES. The Board of Directors may, by resolution passed
by a majority of the entire Board, designate one or more committees, each
committee to consist of two or more of the directors of the Corporation and each
to have such lawfully delegable powers and duties as the Board may confer. Each
such committee shall serve at the pleasure of the Board of



                                       5
<PAGE>


Directors. The Board may designate one or more directors as alternate members of
any committee, who may replace any absent or disqualified member at any meeting
of the committee. Except as otherwise provided by law, any such committee, to
the extent provided in the resolution of the Board of Directors, shall have and
may exercise all the powers and authority of the Board of Directors in the
management of the business and affairs of the Corporation and may authorize the
seal of the Corporation to be affixed to all papers which may require it. Any
committee or committees so designated by the Board shall have such name or names
as may be determined from time to time by resolution adopted by the Board of
Directors. Unless otherwise prescribed by the Board of Directors, a majority of
the members of the committee shall constitute a quorum for the transaction of
business, and the act of a majority of the members present at a meeting at which
there is a quorum shall be the act of such committee. Each Committee shall act
at meetings held pursuant to duly issued notice as set out in Section 5 of this
Article, waivers of notice or unanimous written consent. Each committee shall
prescribe its own rules for calling and holding meetings and its method of
procedure, subject to any rules prescribed by the Board of Directors, and shall
keep a written record of all actions taken by it. No such committee shall have
the power or authority:

                  (a) to amend the Certificate of Incorporation or provide for
         the issuance of shares of stock or fix the designations and any of the
         preferences or rights of shares or the conversion into, or the exchange
         of shares for, shares of any class or classes or any other series of
         the same of the Corporation or fix the number of shares of any series
         of stock or authorize the increase or decrease of the shares of any
         series;

                  (b) to adopt an agreement of merger or consolidation under
         Section 251 or Section 252 of the General Corporation Law of the State
         of Delaware;

                  (c) to recommend to the stockholders the sale, lease or
         exchange of all or substantially all of the Corporation's property and
         assets;

                  (d) to recommend to the stockholders a dissolution of the
         Corporation or a revocation of a dissolution;

                  (e) to amend the Bylaws of the Corporation; or

                  (f) to declare a dividend.

         Section 10. COMPENSATION. The Board of Directors may establish such
compensation for, and reimbursement of the expenses of, directors for attendance
at meetings of the Board of Directors or committees, or for other services by
directors to the Corporation, as the Board of Directors may reasonably
determine. [Section 141(h).]

         Section 11. REGULATIONS; MANNER OF ACTING. To the extent consistent
with applicable law, the Certificate of Incorporation and these Bylaws, the
Board of Directors may adopt such special rules and regulations for the conduct
of their meetings and for the management of the property, affairs and business
of the Corporation as the Board of Directors may deem appropriate. The directors
shall act only as a Board, and the individual directors shall have no power as
such.



                                       6
<PAGE>


                                   ARTICLE III

                                     NOTICES

         Section 1. GENERALLY. Whenever by law or under the provisions of the
Certificate of Incorporation or these Bylaws notice is required to be given to
any director or stockholder, it shall not be construed to mean personal notice,
but such notice may be given in writing, by mail or national courier service,
addressed to such director or stockholder, at his address as it appears on the
records of the Corporation, with postage thereon prepaid, and such notice shall
be deemed to be given at the time when the same shall be deposited in the United
States mail or with such courier service. Notice to directors may also be given
by facsimile transmission, telegram or telephone. [Section 222(b).]

         Section 2. WAIVERS. Whenever any notice is required to be given by law
or under the provisions of the Certificate of Incorporation or these Bylaws, a
waiver thereof in writing, signed by the person or persons entitled to such
notice, whether before or after the time of the event for which notice is to be
given, shall be deemed equivalent to such notice. Attendance of a person at a
meeting shall constitute a waiver of notice of such meeting, except when the
person attends a meeting for the express purpose of objecting, at the beginning
of the meeting, to the transaction of any business because the meeting is not
lawfully called or convened. [Section 229.]

                                   ARTICLE IV

                                    OFFICERS

         Section 1. GENERALLY. The officers of the Corporation shall be elected
by the Board of Directors and shall consist of a Chief Executive Officer, a
President, a Chief Operating Officer, a Secretary and a Treasurer. The Board of
Directors may also choose any or all of the following: a Chairman of the Board
of Directors, one or more Vice Presidents, and one or more Assistant Secretaries
and Assistant Treasurers or any other officers deemed necessary by the Board of
Directors. Any number of offices may be held by the same person. [Section
142(a).]

         Section 2. COMPENSATION. The compensation of the Chief Executive
Officer, the President and all officers and agents of the Corporation who are
also directors of the Corporation shall be fixed by the Board of Directors. The
Board of Directors may delegate the power to fix the compensation of other
officers and agents of the Corporation to an officer of the Corporation and, in
the absence of any express designation, the Chief Executive Officer, if one is
appointed, otherwise the President, shall have the power to fix such amounts.

         Section 3. ELECTION. The officers of the Corporation shall hold office
until their successors are elected and qualified. Any officer elected or
appointed by the Board of Directors may be removed at any time by the
affirmative vote of a majority of the directors. Any vacancy occurring in any
office of the Corporation may be filled by the Board of Directors. [Section
142(b).]

         Section 4. AUTHORITY AND DUTIES. Each of the officers of the
Corporation shall have such authority and shall perform such duties as are
customarily incident to their respective offices or



                                       7
<PAGE>


as may be specified from time to time by the Board of Directors in a resolution
which is not inconsistent with these Bylaws. [Section 142(a).]

         Section 5. REMOVAL AND RESIGNATION; VACANCIES. Any officer may be
removed for or without cause at any time by the Board of Directors. Any officer
may resign at any time by delivering a written notice of resignation, signed by
such officer, to the Board of Directors or the President. Unless otherwise
specified therein, such resignation shall take effect upon delivery. Any vacancy
occurring in any office of the Corporation by death, resignation, removal or
otherwise shall be filled by the Board of Directors. [Sections 142(b), (e).]

         Section 6. CHAIRMAN. The Chairman of the Board of Directors shall
preside at all meetings of the stockholders and of the Board of Directors and
shall have such other duties and responsibilities as may be assigned to him or
her by the Board of Directors. The Chairman may delegate to any qualified person
authority to chair any meeting of the stockholders, either on a temporary or a
permanent basis. [Section 142(a).]

         Section 7. PRESIDENT/CHIEF EXECUTIVE OFFICER. The President shall be
the principal executive officer of the Company unless a separate Chief Executive
Officer is appointed by the Board of Directors. The Chief Executive Officer, if
one is appointed, otherwise the President, shall carry out and direct the
operations of the Company under the direction of the Board of Directors, subject
to the specific delegation of any duties to a separate Chief Executive Officer.
The President or the Chief Executive Officer, if one is appointed, shall preside
at all meetings of the shareholders. The President and the Chief Executive
Officer, if one is appointed, shall have general power to execute contracts,
notes, bonds and other instruments on behalf of the Company and shall have such
other duties and responsibilities as may be prescribed by the Board of Directors
from time to time. In the absence of a Secretary, the President shall perform
the duties thereof. [Section 142(a).]

         Section 7A. CHIEF OPERATING OFFICER. The Chief Operating Officer shall
carry out and direct the operations of the Company under the direction of the
Chief Executive Officer.

         Section 8. EXECUTION OF DOCUMENTS AND ACTION WITH RESPECT TO SECURITIES
OF OTHER CORPORATIONS. The Chief Executive Officer, the President, the Chief
Operating Officer and the Executive Vice President shall have and are hereby
given full power and authority, except as otherwise required by law or directed
by the Board of Directors, (a) to execute, on behalf of the Corporation, all
duly authorized contracts, agreements, deeds, conveyances or other obligations
of the Corporation, applications, consents, proxies and other powers of attorney
and other documents and instruments and (b) to vote and otherwise act on behalf
of the Corporation, in person or by proxy, at any meeting of stockholders (or
with respect to any action of such stockholders) of any other corporation in
which the Corporation may hold securities and otherwise to exercise any and all
rights and powers which the Corporation may possess by reason of its ownership
of securities of such other corporation. In addition, the Chief Executive
Officer, if one is appointed, otherwise the President, may delegate to the
Secretary or to other officers, employees and agents of the Corporation the
power and authority to take any action which the Chief Executive Officer, if one
is appointed, otherwise the President, is authorized to take under this Section
8 of this Article IV, with such limitations as the Chief Executive Officer, if
one is appointed, otherwise the President, may specify; such authority so
delegated by the



                                       8
<PAGE>


Chief Executive Officer, if one is appointed, otherwise the President, shall not
be redelegated by the person to whom such execution authority has been
delegated. [Section 142(a).]

         Section 9. VICE PRESIDENT. Each Vice President, however titled, shall
perform such duties and services and shall have such authority and
responsibilities as shall be assigned to or required from time to time by the
Board of Directors or the President. [Section 142(a).]

         Section 10. SECRETARY AND ASSISTANT SECRETARIES. (a) The Secretary
shall attend all meetings of the stockholders and all meetings of the Board of
Directors and record all proceedings of the meetings of the stockholders and of
the Board of Directors and shall perform like duties for the standing committees
when requested by the Board of Directors, the President or the Chairman. The
Secretary shall give, or cause to be given, notice of all meetings of the
stockholders and meetings of the Board of Directors. The Secretary shall perform
such duties as may be prescribed by the Board of Directors or its Chairman or
the Chief Executive Officer, if one is appointed, otherwise the President. The
Secretary shall have charge of the seal of the Corporation and authority to
affix the seal to any instrument. The Secretary or any Assistant Secretary may
attest to the corporate seal by handwritten or facsimile signature. The
Secretary shall keep and account for all books, documents, papers and records of
the Corporation except those for which some other officer or agent has been
designated or is otherwise properly accountable. The Secretary shall have
authority to sign stock certificates.

         (b) Assistant Secretaries, in the order of their seniority, shall
assist the Secretary and, if the Secretary is unavailable or fails to act,
perform the duties and exercise the authorities of the Secretary.
[Section 142(a).]

         Section 11. TREASURER AND ASSISTANT TREASURERS. (a) The Treasurer, if
so designated, shall be the Chief Financial Officer of the Corporation and may
be known as such. The Treasurer shall have the custody of the funds and
securities belonging to the Corporation and shall deposit all moneys and other
valuable effects in the name and to the credit of the Corporation in such
depositories as may be designated by the Treasurer or the President. The
Treasurer shall disburse the funds and pledge the credit of the Corporation and
shall render to the Board of Directors and the President, as and when required
by them, or any of them, an account of all transactions by the Treasurer.

         (b) Assistant Treasurers, in the order of their seniority, shall assist
the Treasurer and, if the Treasurer is unable or fails to act, perform the
duties and exercise the powers of the Treasurer. [Section 142(a).]

                                    ARTICLE V

                                 INDEMNIFICATION

         Section 1. RIGHT TO INDEMNIFICATION. Each person who was or is made a
party or is threatened to be made a party to or is otherwise involved in any
action, suit or proceeding, whether civil, criminal, administrative or
investigative (hereinafter a "proceeding"), by reason of the fact that he or she
is or was a director or officer of the Corporation or is or was serving at the
request of the Corporation as a director, officer or employee of another
corporation or of a



                                       9
<PAGE>


partnership, joint venture, trust or other enterprise, including service with
respect to employee benefit plans (hereinafter an "indemnitee"), whether the
basis of such proceeding is alleged action in an official capacity as a
director, officer or employee or in any other capacity while serving as a
director, officer or employee, shall be indemnified and held harmless by the
Corporation to the fullest extent authorized by the General Corporation Law of
the State of Delaware, as the same exists or may hereafter be amended (but, in
the case of any such amendment, only to the extent that such amendment permits
the Corporation to provide broader indemnification rights than such law
permitted the Corporation to provide prior to such amendment), against all
expense, liability and loss (including attorneys' fees, judgments, fines, ERISA
excise taxes or penalties and amounts paid in settlement) reasonably incurred or
suffered by such indemnitee in connection therewith and such indemnification
shall continue as to an indemnitee who has ceased to be a director, officer,
employee or agent and shall inure to the benefit of the indemnitee's heirs,
executors and administrators; provided, however, that, except as provided in
Section 2 of this Article V with respect to proceedings to enforce rights to
indemnification, the Corporation shall indemnify any such indemnitee in
connection with a proceeding (or part thereof) initiated by such indemnitee only
if such proceeding (or part thereof) was authorized by the Board of Directors of
the Corporation. The right to indemnification conferred in this Section 1 of
this Article V shall be a contract right and shall include the right to be paid
by the Corporation the expenses incurred in defending any such proceeding in
advance of its final disposition (hereinafter an "advancement of expenses"); and
provided, further, that, if the General Corporation Law of the State of Delaware
requires it, an advancement of expenses incurred by an indemnitee in his or her
capacity as a director or officer (and not in any other capacity in which
service was or is rendered by such indemnitee, including, without limitation,
service to an employee benefit plan) shall be made only upon delivery to the
Corporation of an undertaking, by or on behalf of such indemnitee, to repay all
amounts so advanced if it shall ultimately be determined by final judicial
decision from which there is no further right to appeal that such indemnitee is
not entitled to be indemnified for such expenses under this Article V or
otherwise (hereinafter an "undertaking").

         Section 2. RIGHT OF INDEMNITEE TO BRING SUIT. If a claim under Section
1 of this Article V is not paid in full by the Corporation within 60 days after
a written claim has been received by the Corporation, except in the case of a
claim for an advancement of expenses, in which case the applicable period shall
be 20 days, the indemnitee may at any time thereafter bring suit against the
Corporation to recover the unpaid amount of the claim. If successful in whole or
part in any such suit or in a suit brought by the Corporation to recover an
advancement of expenses pursuant to the terms of an undertaking, the indemnitee
shall be entitled to be paid also the expense of prosecuting or defending such
suit. In any suit brought by the indemnitee to enforce a right to
indemnification hereunder (but not in a suit brought by the indemnitee to
enforce a right to an advancement of expenses), it shall be a defense that the
indemnitee has not met the applicable standard of conduct set forth in the
General Corporation Law of the State of Delaware. Likewise, in any suit by the
Corporation to recover an advancement of expenses pursuant to the terms of an
undertaking, the Corporation shall be entitled to recover such expenses upon a
final adjudication that the indemnitee has not met such standards. Neither the
failure of the Corporation (including its Board of Directors, independent legal
counsel or its stockholders) to have made a determination prior to the
commencement of such suit that indemnification of the indemnitee is proper in
the circumstances because the indemnitee has met the applicable standard of
conduct set forth in the General Corporation Law of the State of



                                       10
<PAGE>


Delaware, nor an actual determination by the Corporation (including its Board of
Directors, independent legal counsel or its stockholders) that the indemnitee
has not met such applicable standard of conduct, shall create a presumption that
the indemnitee has not met the applicable standard of conduct or, in the case of
such a suit brought by indemnitee, be a defense to such suit. In any suit
brought by the indemnitee to enforce a right hereunder, or by the Corporation to
recover an advancement of expenses pursuant to the terms of an undertaking, the
burden of proving that the indemnitee is not entitled to be indemnified or to
such advancement of expenses under this Article V or otherwise shall be on the
Corporation.

         Section 3. NONEXCLUSIVITY OF RIGHTS. The rights of indemnification and
to the advancement of expenses conferred in this Article V shall not be
exclusive of any other right which any person may have or hereafter acquire
under any statute, provision of the Certificate of Incorporation, bylaw,
contract, agreement, vote of stockholders or disinterested directors or
otherwise.

         Section 4. INSURANCE. The Corporation may maintain insurance, at its
expense, to protect itself and any indemnitee against any expense, liability or
loss, whether or not the Corporation would have the power to indemnify such
person against such expense, liability or loss under the General Corporation Law
of the State of Delaware.

         Section 5. INDEMNIFICATION OF AGENTS OF THE CORPORATION. The
Corporation may, to the extent authorized from time to time by the Board of
Directors, grant rights to indemnification and to the advancement of expenses to
any employee or agent of the Corporation to the fullest extent of the provisions
of this Article V or as otherwise permitted under the General Corporation Law of
the State of Delaware with respect to the indemnification and advancement of
expenses of directors and officers of the Corporation.

         Section 6. INDEMNIFICATION CONTRACTS. The Board of Directors is
authorized to enter into a contract with any director, officer, employee or
agent of the Corporation, or any person serving at the request of the
Corporation as a director, officer, employee or agent of another corporation,
partnership, joint venture, trust or other enterprise, including employee
benefit plans, providing for indemnification rights equivalent to or, if the
Board of Directors so determines, greater than, those provided for in this
Article V.

         Section 7. EFFECT OF AMENDMENT. Any amendment, repeal or modification
of any provision of this Article V by the stockholders or the directors of the
Corporation shall not adversely affect any right or protection of a director or
officer of the Corporation existing at the time of such amendment, repeal or
modification. [Section 145.]

                                   ARTICLE VI

                                      STOCK

         Section 1. CERTIFICATES. Certificates representing shares of stock of
the Corporation shall be in such form as shall be determined by the Board of
Directors, subject to applicable legal requirements. Such certificates shall be
numbered and their issuance recorded in the books of the Corporation, and such
certificates shall exhibit the holder's name and the number of shares



                                       11
<PAGE>


and shall be signed by, or in the name of the Corporation by, the Chief
Executive Officer, if one is appointed, otherwise the President and the
Secretary or an Assistant Secretary or the Treasurer or an Assistant Treasurer
of the Corporation. Any or all of the signatures and the seal of the
Corporation, if any, upon such certificates may be facsimiles, engraved or
printed. [Section 158.]

         Section 2. TRANSFER. Upon surrender to the Corporation or the transfer
agent of the Corporation of a certificate for shares duly endorsed or
accompanied by proper evidence of succession, assignment or authority to
transfer, it shall be the duty of the Corporation to issue, or to cause its
transfer agent to issue, a new certificate to the person entitled thereto,
cancel the old certificate and record the transaction upon its books.
[Section 151.]

         Section 3. LOST, STOLEN OR DESTROYED CERTIFICATES. The Secretary may
direct a new certificate or certificates to be issued in place of any
certificate or certificates theretofore issued by the Corporation alleged to
have been lost, stolen or destroyed upon the making of an affidavit of that
fact, satisfactory to the Secretary, by the person claiming the certificate of
stock to be lost, stolen or destroyed. As a condition precedent to the issuance
of a new certificate or certificates, the Secretary may require the owner of
such lost, stolen or destroyed certificate or certificates to give the
Corporation a bond in such sum and with such surety or sureties as the Secretary
may direct as indemnity against any claims that may be made against the
Corporation with respect to the certificate alleged to have been lost, stolen or
destroyed or the issuance of the new certificate. [Section 167.]

         Section 4. RECORD DATE. (a) In order that the Corporation may determine
the stockholders entitled to notice of or to vote at any meeting of stockholders
or any adjournment thereof, the Board of Directors may fix a record date, which
record date shall not precede the date upon which the resolution fixing the
record date is adopted by the Board of Directors, and which record date shall
not be more than 60 nor less than 10 days before the date of such meeting. If no
record date is fixed by the Board of Directors, the record date for determining
stockholders entitled to notice of or to vote at a meeting of stockholders shall
be at the close of business on the day next preceding the day on which notice is
given or, if notice is waived, at the close of business on the day next
preceding the day on which the meeting is held. A determination of stockholders
of record entitled to notice of or to vote at a meeting of stockholders shall
apply to any adjournment of the meeting; provided, however, that the Board of
Directors may fix a new record date for the adjourned meeting.

         (b) In order that the Corporation may determine the stockholders
entitled to receive payment of any dividend or other distribution or allotment
of any rights or the stockholders entitled to exercise any rights in respect of
any change, conversion or exchange of stock, or for the purpose of any other
lawful action, the Board of Directors may fix a record date, which record date
shall not precede the date upon which the resolution fixing the record date is
adopted, and which record date shall be not more than 60 days prior to such
action. If no record date is fixed, the record date for determining stockholders
for any such purpose shall be at the close of business on the day on which the
Board of Directors adopts the resolution relating thereto. [Section 213.]

                                   ARTICLE VII



                                       12
<PAGE>


                               GENERAL PROVISIONS

         Section 1. FISCAL YEAR. The fiscal year of the Corporation shall be the
calendar year or such other annual period as shall be fixed from time to time by
the Board of Directors.

         Section 2. CORPORATE SEAL. The Board of Directors may adopt a corporate
seal and use the same by causing it or a facsimile thereof to be impressed or
affixed or reproduced or otherwise.

         Section 3. RELIANCE UPON BOOKS, REPORTS AND RECORDS. Each director,
each member of a committee designated by the Board of Directors, and each
officer of the Corporation shall, in the performance of his or her duties, be
fully protected in relying in good faith upon the records of the Corporation and
upon such information, opinions, reports or statements presented to the
Corporation by any of the Corporation's officers or employees, or committees of
the Board of Directors, or by any other person as to matters the director,
committee member or officer believes are within such other person's professional
or expert competence and who has been selected with reasonable care by or on
behalf of the Corporation. [Section 141(e)]

         Section 4. TIME PERIODS. In applying any provision of these Bylaws
which requires that an act be done or not be done a specified number of days
prior to an event or that an act be done during a period of a specified number
of days prior to an event, calendar days shall be used, the day of the doing of
the act shall be excluded and the day of the event shall be included.

         Section 5. DIVIDENDS. The Board of Directors may from time to time
declare and the Corporation may pay dividends upon its outstanding shares of
capital stock, in the manner and upon the terms and conditions provided by law
and the Certificate of Incorporation. [Section 173.]

                                  ARTICLE VIII

                               AMENDMENT OF BYLAWS

         In furtherance and not in limitation of the powers conferred upon it by
law, the Board of Directors is expressly authorized to adopt, repeal, alter or
amend the Bylaws of the Corporation by the affirmative vote of a majority or
more of the entire Board of Directors. In addition to any requirements of law
and any provision of the Certificate of Incorporation, the stockholders of the
Corporation may adopt, repeal, alter or amend any provision of the Bylaws upon
the affirmative vote of the holders of a majority or more of the combined voting
power of the then outstanding stock of the Corporation entitled to vote
generally in the election of directors. [Section 109(a).]



                                       13
<PAGE>


                            CERTIFICATE OF SECRETARY

                                       OF

                               TRANSGENOMIC, INC.

                            (A DELAWARE CORPORATION)

         I hereby certify that I am the duly elected and acting Secretary of
said Corporation and that the foregoing Bylaws of said Corporation, comprising
15 pages, constitute the Bylaws of said Corporation as duly adopted by the Board
of Directors thereof by action taken at a special meeting thereof.

Date:  June 27, 1997                        /s/ P. Thomas Pogge
                                            ------------------------------------
                                            Secretary


                                      14


<PAGE>

                                                                       EXHIBIT 4


                       INCORPORATED UNDER THE LAWS OF THE

                                STATE OF DELAWARE

NUMBER _____________                                           __________ SHARES

                                                                  CUSIP [NUMBER]


                              [LOGO OF REGISTRANT]

                               Transgenomic, Inc.

                                  Common Stock

THIS CERTIFIES THAT ____________________________________________ is the owner of

_____________________________________________ Shares of the Capital Stock of
Transgenomic, Inc.

                                    Transferrable only on the Books of the
                                    Corporation by the holder hereof in person
                                    or by duly authorized Attorney, on
                                    surrender of this Certificate properly
                                    endorsed.

[SEAL]                              IN WITNESS WHEREOF the duly authorized
                                    officers of this Corporation have hereunto
                                    subscribed their names and caused the
                                    corporate Seal to be hereto affixed at
                                    Omaha, Nebraska    this
                                    -----------------       ------------------
                                    day of                 A.D.
                                           ---------------     ---------------

                  _______________________________         _____________________
                  Chief Executive Officer                 Secretary


                            Par Value per Shares $0.01


<PAGE>


                                   CERTIFICATE

                                       FOR
                                   ___________

                                     SHARES

                                     OF THE

                                  CAPITAL STOCK

                               Transgenomic, Inc.

                                    ISSUED TO

                              _____________________

                                      DATED

                              _____________________


For value received _____ hereby sell assign and transfer unto _________________

_________________________________________________________________________ Shares

of the Capital Stock represented by the within certificate and do hereby

irrevocably constitute and appoint_____________________________________________

_______________________________to transfer the said Stock on the books of the

within named Corporation with full power of substitution in the premises.

         Dated: ______________________________

                  In the presence of

                  ______________________________________________________________

NOTICE: THE SIGNATURE OF THIS ASSIGNMENT MUST CORRESPOND WITH THE NAME AS
WRITTEN UPON THE FACE OF THE CERTIFICATE, IN EVERY PARTICULAR, WITHOUT
ALTERATION, ENLARGEMENT OR ANY CHANGE WHATEVER.


                                       2


<PAGE>

                                                                    EXHIBIT 10.1

                             WARRANT FOR PURCHASE OF
                                  COMMON STOCK
                                       OF
                               TRANSGENOMIC, INC.

         1. WARRANT. The undersigned ("Holder") is entitled to purchase from
Transgenomic, Inc., a Delaware corporation (the "Company"), on the terms herein
stated, 300,000 shares of Common Stock of the Company, par value $.01 per share
(the "Common Stock"), and upon such purchase to receive a certificate or
certificates representing such shares. The price payable to the Company on the
exercise of the purchase right evidenced by this Warrant (hereinafter referred
to as the "Exercise Price") shall be the lesser of (i) Five Dollars ($5.00) per
share of Common Stock or (ii) 50% of the price per share at which the Company
first offers Common Stock to the public pursuant to a registration statement
which has become effective under the Securities Act of 1933, as amended;
provided that, in either case, the number of shares of Common Stock purchasable
upon the exercise of this Warrant and the Exercise Price may be adjusted from
time to time and other property may become deliverable hereunder pursuant to the
provisions set forth herein. In addition, if the Exercise Price is less than
$5.00 per share of Common Stock, Holder may elect to acquire a number of shares
of Common Stock upon the exercise of this Warrant of up to the number determined
by dividing $1,500,000 by such Exercise Price. Holder shall not, by virtue
hereof, be entitled to any rights of a shareholder in the Company, either at law
or in equity, and the rights of the holder of this Warrant are limited to those
expressed herein. This Warrant is one of a series of similar warrants to be
issued by the Company to the Holder pursuant to the terms of a Securities
Purchase Agreement by and among the Holder and the Company, dated December 16,
1997 (the "Purchase Agreement").

         2. METHOD OF EXERCISE.

         (a) Holder may exercise the Warrant at any time on or after the date
hereof, and from time to time thereafter until the date of expiration set forth
in paragraph (b) of this Section 2, by delivery to the Company of a written
notice of Holder's intent to exercise the Warrant. Holder shall purchase such
number of shares indicated in such notice no later than seven days after the
delivery of such notice to the Company at a closing to take place at the
executive offices of the Company, unless an earlier closing is required
hereunder (the "Closing"). At the Closing, Holder shall deliver the Exercise
Price for such shares in good funds to the Company (which may consist of an
offset against all or part of any amount owed by the Company to the Holder
pursuant to a Promissory Note, dated as of the date hereof, in the principal
amount of $1,500,000) and the Company shall deliver to Holder fully executed
certificates evidencing such shares. In the event that Holder exercises the
Warrant for a number of shares less than the total number of shares which Holder
has a right to purchase under the Warrant, then the Company shall issue Holder a
Warrant identical in form with this Warrant but for a number of shares equal to
the amount Holder had the right to purchase immediately prior to such exercise
less the amount so purchased. The effective date of exercise shall be the date
at which the Company received notice of the intent to exercise the Warrant.

         (b) If this Warrant is not effectively exercised on or before the
closing date of the initial offering of Common Stock by the Company to the
public pursuant to a registration statement which has become effective under the
Securities Act of 1933, as amended (the "Securities Act"), then all rights of
Holder under this Warrant shall expire.


<PAGE>


         3. HOLDER REPRESENTATIONS AND RESTRICTIONS ON TRANSFER. Holder hereby
represents as follows:

         (a) Holder is acquiring this Warrant and any Common Stock acquired upon
exercise of this Warrant for his own account, for investment purposes only and
not with a view to, or for resale in connection with, any distribution thereof
except pursuant to an effective registration statement under the Securities Act,
or pursuant to an exemption from such registration afforded by the Securities
Act.

         (b) Holder is an "accredited investor" as defined in Rule 501 of
Regulation D promulgated under the Securities Act and expects to be an
"accredited investor" at the time, if any, of the exercise of this Warrant.

         (c) Holder understands that, because the Common Stock issuable under
this Warrant has not been registered under the Securities Act, Holder cannot
dispose of any or all of the Common Stock acquired upon the exercise of this
Warrant unless such shares are subsequently registered under the Securities Act
or exemptions from registration are available. Holder acknowledges and agrees
that the Company is under no obligation to register any shares of Common Stock
which may be issued to Holder upon exercise of the Warrants under federal or
state securities laws, except as provided in the Registration Rights Agreement
by and between the Company and the Holder, dated as of the date hereof. By
reason of these restrictions, Holder understands that it may be required to hold
the Common Stock for an indefinite period of time. Holder understands that each
certificate representing the Common Stock will bear a legend substantially
similar to the legend on the Warrant.

         4. ANTIDILUTION. If any of the following events shall occur at any time
or from time to time prior to the expiration of this Warrant, the following
adjustments shall be made in the Exercise Price and/or the number of shares of
Common Stock then purchasable upon the exercise of this Warrant, as appropriate,
with the exceptions hereinafter provided.

         (a) In case the Company shall at any time subdivide its outstanding
shares of Common Stock into a greater number of shares, the Exercise Price in
effect immediately prior to such subdivision shall be proportionately reduced
and the number of shares purchasable under this Warrant shall be proportionately
increased; and conversely, in case the Common Stock of the Company shall be
combined into a smaller number of shares, the Exercise Price in effect
immediately prior to such combination shall be proportionately increased and the
number of shares purchasable hereunder shall be proportionately reduced.

         (b) If the Company shall declare a dividend on its Common Stock payable
in stock or other securities of the Company or of any other corporation, or in
property or otherwise than in cash, to holders of record of Common Stock as of a
date prior to the date of exercise of this Warrant, Holder shall, without
additional cost, be entitled to receive upon the exercise hereof, in addition to
the Common Stock to which Holder is otherwise entitled upon such exercise, the
number of shares of stock or other securities or property which Holder would
have been entitled to receive if Holder had been a holder of such Common Stock
on such record date.

         (c) If the Company shall issue any shares of its Common Stock at an
offering price of less than $5.00 per share, the Exercise Price shall be reduced
to the price at which such shares were issued and the number of shares
purchasable under this Warrant shall be proportionately increased; provided,
however, that the foregoing shall not affect the determination of the Exercise
Price pursuant to clause (ii) of the second sentence of Section 1 hereof.

         (d) No fractional shares of Common Stock are to be issued upon the
exercise of this Warrant, but the Company shall pay a cash adjustment in respect
of any fraction of a share which would otherwise be issuable in an amount equal
to the same fraction of the fair market value per share of Common Stock on the
day of exercise, as reasonably determined by the board of


<PAGE>


directors; however, such determination shall not take into any account any
restraints on the transferability of the Common Stock.

         5. DIVIDENDS. If the Company shall after the date hereof decide to
declare a dividend or dividends on its Common Stock payable in cash or other
property to the holders of record of Common Stock as of a date prior to the date
of Holder becoming a holder of record of Common Stock through the exercise of
this Warrant, the Company shall give Holder at least ten (10) days' notice of
the record date for determining the stockholders of record who are entitled to
such dividend, so that Holder may, at its discretion, exercise its rights under
this Warrant and participate in such dividend. If the Company fails to provide
such notice, the amount of cash dividends or other property per share declared
by the Company, times the total shares of Common Stock into which the Warrant is
exercisable, shall be placed in a separate account of the Company and reserved
for payment to Holder upon exercise of this Warrant and shall be paid on a
per-share basis upon exercise of this Warrant.

         6. TRANSFERABILITY. Other than as contemplated in the Purchase
Agreement, Holder may not sell, assign, pledge or otherwise transfer all or part
of its rights under this Warrant without the prior written consent of the
Company. Upon the occurrence of an Event of Default under the Promissory Note,
dated as of the date hereof, from the Company to the Holder, this Warrant may be
transferred by the Holder without the consent of the Company. A transfer of this
Warrant may be made only in compliance with applicable securities laws.
Permitted transferees hereof shall have the rights of Holder hereunder and the
Company agrees to reissue to such permitted transferee a Warrant substantially
identical in form with this Warrant for such number of shares so transferred and
to issue to Holder a Warrant identical in form with this Warrant covering the
number of shares not transferred.

         7. RESERVATION OF SECURITIES. The Company shall at all times reserve
and keep available out of its authorized capital stock, solely for the purpose
of issuance upon the exercise of the Warrant, such number of shares of Common
Stock as shall be issuable upon exercise thereof. The Company covenants and
agrees that, upon exercise of the Warrant and payment of the Exercise Price
therefor, all shares of Common Stock issuable upon such exercise shall be duly
and validly issued, fully paid, nonassessable and not subject to the preemptive
rights of any shareholder.

         8. NOTICES. All notices, requests, consents and other communications
hereunder shall be in writing and shall be deemed to have been duly made when
delivered by overnight express delivery:

          (a)  If to Holder, to the address of Holder as shown on the books of
the Company; or

          (b)  If to the Company, at Transgenomic, Inc., 5600 South 42nd Street,
Omaha, Nebraska 68107, Attention: P. Thomas Pogge or to such other address as
the Company may designate by notice to Holder.

         9.       SUPPLEMENTS AND AMENDMENTS.

         (a) The Company and Holder may from time to time supplement or amend
this Warrant in order to cure any ambiguity, to correct or supplement any
provision contained herein which may be defective or inconsistent with any
provision herein, or to make other provisions in regard to matters of questions
arising hereunder which the Company and Holder may deem necessary or desirable.


<PAGE>


         (b) The exercise of this Warrant and the issuance of Common Stock upon
said exercise is subject to the terms and conditions of a Shareholders
Agreement, dated July 1, 1997, by and among the Company and its shareholders, to
which the Holder agrees to become a party upon exercise of this Warrant and as a
condition to the issuance of shares of Common Stock to the Holder. The
Shareholder Agreement shall not be amended without the consent of the Holder.

         10. SUCCESSORS. All the covenants, agreements, representations and
warranties contained in this Warrant shall bind the parties hereto and their
respective heirs, executors, administrators, distributees, successors and
assigns.

         11. GOVERNING LAW. This Warrant shall be deemed to be a contract made
under the laws of the State of Nebraska and for all purposes shall be construed
in accordance with its laws without giving effect to the rules governing the
conflict of laws.

         THE WARRANT EVIDENCED BY THIS CERTIFICATE AND THE SHARES OF COMMON
STOCK ISSUABLE UPON EXERCISE OF THE WARRANT EVIDENCED BY THIS CERTIFICATE HAVE
NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 OR ANY STATE SECURITIES ACT
AND MAY ONLY BE SOLD OR TRANSFERRED IN COMPLIANCE WITH THAT ACT AND APPLICABLE
STATE SECURITIES LAWS.


<PAGE>


DATED:  December 16, 1997.

THE COMPANY
Transgenomic, Inc.

By /s/ Collin J. D'Silva
- -------------------------------------------
Collin J. D'Silva, Chief Executive Officer

THE HOLDER

/s/ G.S. Beckwith Gilbert
- -------------------------------------------
G.S. Beckwith Gilbert

<PAGE>

                                                                    EXHIBIT 10.2

                          REGISTRATION RIGHTS AGREEMENT

         This Registration Rights Agreement (the "Rights Agreement") is entered
into as of December 16, 1997 by and among G.S. Beckwith Gilbert (the
"Shareholder") and Transgenomic, Inc. (the "Company").

         Section 1. DEFINITIONS. Certain other terms utilized in this Agreement
shall have the meanings indicated herein:

         "COMMISSION" means the U.S. Securities and Exchange Commission.

         "EXCHANGE ACT" means the Securities Exchange Act of 1934, as amended.

         "REGISTRABLE SECURITIES" shall consist of the shares of Common Stock
acquired by the Shareholder pursuant to the warrants issued by the Company to
the Shareholder pursuant to the terms of a Securities Purchase Agreement by and
between the Shareholder and the Company and dated as of the date hereof.
Registrable Securities shall not include: (i) any of such shares sold pursuant
to an effective registration statement under the Securities Act; (ii) any of
such shares sold under circumstances in which all of the applicable conditions
to Rule 144 (or successor provision) under the Securities Act are met; and (iii)
any of such shares that are no longer subject to any restrictions on transfer
pursuant to Rule 144(k) (or successor provision) under the Securities Act.

         "REGISTRATION EXPENSES" means all expenses incurred by the Company in
connection with the registration of Registrable Securities pursuant to this
Agreement, including (a) all registration and filing fees paid to the
Commission; (b) fees and expenses of compliance with state securities or blue
sky laws (including reasonable fees and disbursements of counsel in connection
with blue sky qualifications of the Registrable Securities); (c) printing
expenses; (d) internal expenses (including, without limitation, all salaries and
expenses of the Company's officers and employees performing legal or accounting
duties); (e) the fees and expenses incurred in connection with any listing of
the Registrable Securities on a national or regional exchange, the NASDAQ Stock
Market or similar facility; (f) fees and expenses of counsel for the Company and
fees and expenses for independent certified public accountants retained by the
Company (including the expenses of any comfort letters or costs associated with
the delivery by any independent certified public accountants of any comfort
letters); and (g) the reasonable fees and expenses of any special experts
retained by the Company in connection with such registration.

         "SECURITIES ACT" means the Securities Act of 1933, as amended.

         "SELLING EXPENSES" means all underwriting fees, discounts, commissions
or expenses attributable to any sale of all or part of the Registrable
Securities.

         Section 2. REGISTRATION RIGHTS. (a) If the Company proposes to file a
registration statement under the Securities Act with respect to either a primary
or secondary offering by the Company of equity securities for its own account
(other than a registration statement relating solely to (i) securities to be
offered to employees pursuant to a stock option, stock savings, or


<PAGE>


other employee benefit plan of the Company or its affiliates; (ii) securities
proposed to be issued in exchange for securities or assets of, or in connection
with a merger or consolidation with, another corporation; (iii) securities to be
offered by the Company generally to any class or series of its then-existing
security holders; or (iv) securities to be offered or issued pursuant to a
combination of the foregoing transactions), then the Company shall give written
notice of such proposed filing to the Shareholder as soon as practicable (but in
no event less than 30 days before the anticipated filing date of such
registration statement), and such notice shall offer the opportunity to include
all or any part of the Registerable Shares owned by the Shareholder with the
securities of the Company being so registered. The Shareholder shall have 15
days following receipt of such notice to request in writing inclusion of all or
any portion of his Registerable Shares in such registration, which request shall
specify the number of Registerable Shares the Shareholder proposes to sell
pursuant thereto.

         (b) Whenever the Shareholder requests that all or part of his
Registerable Shares be included in a proposed registration, the Company shall
use its reasonable best efforts to effect the registration of such Registerable
Shares and to cause the managing underwriter of any proposed underwritten
offering to permit the requested Registerable Shares to be included in such
registration on the same terms and conditions as any similar securities included
therein. The Shareholder may only participate in an underwritten registration
hereunder if he (i) agrees to sell his Registerable Shares on the basis provided
in any underwriting arrangements and (ii) completes and executes all
questionnaires, powers of attorney, indemnities, underwriting agreements and
other documents reasonably required under the terms of such underwriting
arrangements and these registration rights. Among other things, the Shareholder
agrees, whether or not his Registerable Shares are included in an underwritten
offering, that he will join in any general agreement with the managing
underwriter not to effect any public sale or distribution of his Registerable
Shares, including a sale pursuant to Rule 144 under the Securities Act, for a
period of time not to exceed 360 days.

         (c) Notwithstanding anything else set forth in this Section 2, the
Company may, at the discretion of a majority of its Board of Directors and
without the consent of the Shareholder, withdraw any registration and abandon
the proposed offering. Furthermore, if the managing underwriter of an
underwritten offering advises the Company that in its opinion either because of
(A) the size of the offering that the Company, the Shareholder or any other
shareholder desires to make or (B) the kind of securities that the Company and
the Shareholder intend to include in such offering, the success of the offering
could be materially and adversely affected by inclusion of the Registerable
Shares requested to be included, then

                  (i) in the event that the size of the offering is the basis of
         such managing underwriter's opinion, (x) the amount of equity
         securities being offered by any other shareholders of the Company
         pursuant to other registration rights agreements which the Company may
         be party to will be reduced to the extent necessary to reduce the total
         amount of shares included in such offering to the amount recommended by
         the managing underwriter and (y) if an additional reduction in the
         number of shares is required, then the amount of equity securities to
         be offered by the Company and the amount of Registerable Shares to be
         offered for the account of the Shareholder shall be proportionately
         reduced (on the basis of the number of shares each intended to include
         in such offering) to the extent


                                       2
<PAGE>


         necessary to reduce the total amount of shares included in such
         offering to the amount recommended by such managing underwriter; and

                  (ii) in the event that the kind or combination of securities
         to be offered is the basis of such managing underwriter's opinion, the
         amount of Registerable Shares to be included in such offering shall be
         reduced as described in clause (i) above or, if any such reduction
         would, in the judgment of the managing underwriter, be insufficient to
         substantially eliminate the adverse effect that inclusion of the
         Registerable Shares requested to be included could have on such
         offering, such Registerable Shares shall be excluded from such
         offering.

The Company agrees that it will not enter into any other registration rights
agreements which contradict or otherwise interfere with the operation of this
Section 2(c).

         (d) The registration rights under this Section 2 shall apply to the any
registration statement filed by the Company and declared effective under the
Securities Act, other than registration statements relating to those offerings
described in items (i) through (iv) of paragraph (a) of this Section 2.

         (e) The Company shall pay all Registration Expenses in connection with
the registration of Registerable Shares pursuant to this Section 2, whether or
not the registration statement becomes effective. The Shareholder shall pay all
Selling Expenses attributable to any sale of all or part of his Registerable
Shares in connection with any registration, whether or not the registration
statement becomes effective.

         (f) In connection with any registration required under this Agreement,
the Company shall take the actions set forth below.

                  (i) The Company shall notify the Shareholder of any stop order
         issued or threatened by the Commission and will take all reasonable
         actions required to prevent the entry of such stop order or to remove
         it if entered.

                  (ii) The Company shall comply with the provisions of the
         Securities Act with respect to the disposition of all securities
         covered by a registration statement filed pursuant to this Agreement
         with respect to the disposition of all Registrable Securities covered
         by such registration statement in accordance with the intended methods
         of disposition by the Shareholder as set forth in such registration
         statement.

                  (iii) The Company shall furnish to the Shareholder and each
         underwriter, if any, of Registrable Securities covered by a
         registration statement filed pursuant to this Agreement, such number of
         copies of such registration statement, each amendment and supplement
         thereto (in each case including all exhibits thereto), and the
         prospectus included in such registration statement (including each
         preliminary prospectus), in conformity with the requirements of the
         Securities Act, and such other documents as a Shareholder may
         reasonably request in order to facilitate the disposition of the
         Registrable Securities.

                  (iv) The Company shall use its commercially reasonable best
         efforts to register or qualify the Registrable Securities under the
         securities or "blue sky" laws of each state of


                                       3
<PAGE>


         the United States of America as the Shareholder or any of the
         underwriters, if any, of the Registrable Securities covered by a
         registration statement filed hereunder requests to the extent such
         request is deemed reasonable by the Board of Directors of the Company
         in its sole discretion, and shall do any and all other acts and things
         which may be reasonably necessary or advisable to enable the
         Shareholder and each underwriter, if any, to consummate the disposition
         in such states of the Registrable Securities; provided that the Company
         shall not be required to (A) qualify generally to do business in any
         jurisdiction where it would not otherwise be required to qualify but
         for this subsection (iv), (B) subject itself to taxation in any such
         jurisdiction or (C) consent to general service of process in any such
         jurisdiction.

                  (v) The Company shall immediately notify the Shareholder of
         the happening of any event which comes to the Company's attention if,
         as a result of such event, the prospectus included in the registration
         statement filed under this Agreement contains any untrue statement of a
         material fact or omits to state any material fact necessary to make the
         statements therein, in light of the circumstances under which they were
         made, not misleading, and the Company shall promptly prepare and
         furnish to the Shareholder and file with the Commission a supplement or
         amendment to such prospectus so that such prospectus will no longer
         contain any untrue statement of a material fact or omit to state any
         material fact necessary to make the statements therein, in light of the
         circumstances under which they were made, not misleading.

                  (vi) The Company shall make available for inspection by the
         Shareholder, any underwriter participating in any disposition pursuant
         to a registration statement filed under this Agreement, and any
         attorney, accountant or other agent retained by the Shareholder or such
         underwriters, all financial and other records, pertinent corporate
         documents and properties of the Company and its subsidiaries, as such
         person may reasonably request for the purpose of confirming that such
         registration statement does not contain any untrue statement of a
         material fact or omit to state any material fact necessary to make the
         statements therein, in light of the circumstances under which they were
         made, not misleading, provided that the Company obtains reasonably
         satisfactory assurances that such information will be used solely for
         such purpose and will be held in confidence (except to the extent that
         it is included in the registration statement). The Company shall cause
         the officers, directors and employees of the Company and each of its
         subsidiaries to supply such information and respond to such inquiries
         as the Shareholder or such underwriter may reasonably request or make
         for the purpose of confirming that such registration statement does not
         contain any untrue statement of a material fact or omit to state any
         material fact necessary to make the statements therein, in light of the
         circumstances under which they were made, not misleading, provided that
         the Company obtains reasonably satisfactory assurances that such
         information will be used solely for such purpose and will be held in
         confidence (except to the extent that it is included in the
         registration statement).

                  (vii) The Company shall use its commercially reasonable best
         efforts to obtain a "cold comfort" letter from the Company's
         independent public accountants in customary form and covering such
         matters of the type customarily covered by "cold comfort" letters as
         the Shareholder or the underwriters reasonably request.


                                       4
<PAGE>


                  (viii) The Company shall otherwise use its best commercially
         reasonable best efforts to comply with all applicable rules and
         regulations of the Commission, and make generally available to its
         security holders, as soon as reasonably practicable, an earnings
         statement covering a period (which may begin with the first fiscal
         quarter ending after the effective date of the registration statement)
         of at least 12 months after the effective date of the registration
         statement (as the term "effective date" is defined in Rule 158(c) under
         the Securities Act), which earnings statement shall satisfy the
         provisions of Section 11(a) of the Securities Act and Rule 158
         thereunder.

         Section 3. OTHER REGISTRATION RIGHTS. The Shareholder acknowledges that
certain other stockholders of the Company may now or hereafter have registration
rights, and that such other stockholders may be entitled to sell their
securities at the same time, or pursuant to the same registration and
underwriting, as the Holders hereunder.

         Section 4.  INDEMNIFICATION.

                  (a) INDEMNIFICATION BY THE COMPANY. The Company shall
         indemnify and hold harmless the Shareholder and each person, if any,
         who controls the Shareholder within the meaning of Section 15 of the
         Securities Act or Section 20 of the Exchange Act from and against any
         and all losses, claims, damages, liabilities and expenses (including
         reasonable costs of investigation) arising out of or based upon any
         untrue statement or alleged untrue statement of a material fact
         contained in any registration statement or prospectus relating to the
         Registrable Securities or in any amendment or supplement thereto or in
         any preliminary prospectus, or arising out of or based upon any
         omission or alleged omission to state therein a material fact required
         to be stated therein or necessary to make the statements therein not
         misleading, except insofar as such losses, claims, damages, liabilities
         or expenses arise out of, or are based upon, any such untrue statement
         or omission or allegation thereof contained in information furnished in
         writing to the Company by such Shareholder or on such Shareholder's
         behalf; and provided, further, that with respect to any untrue
         statement or omission or alleged untrue statement or omission made in
         any preliminary prospectus, the indemnity contained in this paragraph
         shall not apply to the extent that any such loss, claim, damage,
         liability or expense results from the fact that a current copy of the
         prospectus was not sent or given to the persons or entities asserting
         any such loss, claim, damage, liability or expense at or prior to the
         written confirmation of the sale of the Registrable Securities
         concerned to such persons or entities with a current copy of the
         prospectus and such current copy of the prospectus would have cured the
         defect giving rise to such loss, claim, damage, liability or expense.

                  (b) INDEMNIFICATION BY SHAREHOLDER. The Shareholder agrees to
         indemnify and hold harmless the Company and each person, if any, who
         controls the Company within the meaning of either Section 15 of the
         Securities Act or Section 20 of the Exchange Act to the same extent as
         the foregoing indemnity from the Company to the Shareholder, but only
         with respect to information furnished in writing by the Shareholder or
         on his behalf. The Shareholder agrees to indemnify and hold harmless
         the underwriters of the Registrable Securities, their officers and
         directors and each person who controls such underwriters on terms
         consistent with industry standards in effect at such time.


                                       5
<PAGE>


         Section 5.          MISCELLANEOUS.

                  (a) NOTICES. All notices that are required or may be given
         pursuant to the terms of this Agreement shall be in writing and shall
         be sufficient in all respects if given in writing and delivered
         personally or by a recognized courier service or by registered or
         certified mail, postage prepaid, to any party at its address set forth
         below, with a copy of same by any of the authorized means to the
         indicated person or persons:

         If to the Company: Transgenomic, Inc.
                                    5600 South 42nd Street
                                    Omaha, Nebraska  68107
                                    Attention:  P. Thomas Pogge, General Counsel

         If to Shareholder: G.S. Beckwith Gilbert
                                    Field Point Capital Management Company
                                    104 Field Point Road
                                    Greenwich, Connecticut 06830

                  Any notice or other communication shall be deemed to have been
         given on the day it is personally delivered or delivered by a
         recognized courier service as aforesaid or, if mailed, on the third day
         after it is mailed. Any party may change its address for notices or the
         person or persons authorized to receive notices for it by providing
         notice to the other parties in accordance with this Section.

                  (b) INVALIDITY OF PROVISIONS. If any provision of this
         Agreement is determined to be invalid, illegal or unenforceable, in
         whole or in part, then the parties shall be relieved of all obligations
         arising under such provision to the extent it is invalid, illegal or
         unenforceable, and such provision shall be reformed to the extent
         necessary to make it legal and enforceable while preserving its intent
         or, if that is not possible, by substituting therefor another provision
         that is legal and enforceable and achieves the same objectives.

                  (c) SECTION TITLES. All section titles and captions in this
         Agreement are for convenience only, shall not be deemed part of this
         Agreement and in no way shall define, limit, extend or describe the
         scope or intent of any provisions of this Agreement.

                  (d) FURTHER ACTS. The parties shall execute all documents,
         provide all information and take all such actions as may be reasonably
         necessary or appropriate to achieve the purposes of this Agreement and
         to accomplish the transactions contemplated hereby.

                  (e) ENTIRE AGREEMENT; WAIVER. This Agreement constitutes the
         entire agreement among the parties hereto pertaining to the subject
         matter hereof and supersedes all prior agreements and understandings
         relating to the subject matter hereof. This Agreement cannot be
         modified or amended except in writing signed by the party against whom
         enforcement is sought. No waiver by a party of any of the provisions of
         this Agreement shall be deemed or shall constitute a waiver of any
         other provision of this Agreement, nor shall any such waiver constitute
         a continuing waiver.


                                       6
<PAGE>


                  Although the Shareholder will become a party to the
         Shareholders Agreement, dated July 1, 1997, by and among the Company
         and its shareholders (the "Shareholders Agreement") upon the exercise
         of his warrants, the registration rights granted pursuant to this
         Agreement shall supersede any such rights stated in Section 8 of the
         Shareholders Agreement with respect to the Registerable Shares (but not
         with respect to any other shares of the Company's equity securities
         acquired or held by the Shareholder).

                  (f) COUNTERPARTS. This Agreement may be executed in multiple
         counterparts, all of which together shall constitute one agreement
         binding on the parties hereto, notwithstanding that the parties are not
         signatories to the same counterpart.

                  (g) GOVERNING LAW. This Agreement shall be governed by and
         construed in accordance with the substantive laws of the State of
         Nebraska and the United States, as applicable, without giving effect to
         any conflict of laws provisions that might result in the application of
         the laws of another jurisdiction.

         IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
duly executed as of date first above written.

         TRANSGENOMIC, INC.

         By /s/ Collin D'Silva
            --------------------------------
         Its Chief Executive Officer
            --------------------------------




         /s/ G.S. Beckwith Gilbert
            --------------------------------
         G.S. Beckwith Gilbert

                                       7

<PAGE>


                                                                    EXHIBIT 10.3


            VOID AFTER 3:30 P.M., CENTRAL TIME, ON [______], [______]

                        WARRANT TO PURCHASE COMMON SHARES

                               TRANSGENOMIC, INC.

         This is to certify that, for value received, [HOLDER], [ADDRESS] (the
"Holder"), is entitled to purchase, subject to the provisions of this Warrant,
from TRANSGENOMIC, INC. (the "Company"), a Delaware corporation, at any time
until 3:30 p.m., Central time, on [ ], [ ] ("Expiration Date"), [ ] Common
Shares of the Company at a purchase price per share of $5.00 during the period
this Warrant is exercisable. The number of Common Shares to be received upon the
exercise of this Warrant and the price to be paid for a Common Share may be
adjusted from time to time as hereinafter set forth. The purchase price of a
Common Share in effect at any time and as adjusted from time to time is
hereinafter sometimes referred to as the "Exercise Price." This Warrant is or
may be one of a series of warrants identical in form issued by the Company to
purchase an aggregate [ ] of Common Shares of the Company and the term
"Warrants" as used herein means all such Warrants (including this Warrant). The
Common Shares, as adjusted from time to time, underlying the Warrants are
hereinafter sometimes referred to as "Warrant Shares" and include all Common
Shares that have been issued upon the exercise of the Warrants and all unissued
Common Shares underlying the Warrants.

         SECTION 1. EXERCISE OF WARRANT. This Warrant may be exercised in
whole or in part at any time or from time to time until the Expiration Date
or if the Expiration Date is a day on which banking institutions are
authorized by law to close, then on the next succeeding day which shall not
be such a day, by presentation and surrender hereof to the Company or at the
office of its stock transfer agent, if any, with the Purchase Form annexed
hereto duly executed and accompanied by payment of the Exercise Price for the
number of shares specified in such Form, together with all federal and state
taxes applicable upon such exercise. The Company agrees not to merge,
reorganize or take any action that would terminate this Warrant unless
provisions are made as part of such merger, reorganization or other action
which would provide the holders of this Warrant with an equivalent of this
Warrant as specified in this Section. The Company agrees to provide notice to
the Holder that any tender offer is being made for the Company's Common
Shares no later than three business days after the day the Company becomes
aware that any tender offer is being made for outstanding Common Shares of
the Company. If this Warrant should be exercised in part only, the Company
shall, upon surrender of this Warrant for cancellation, execute and deliver a
new Warrant evidencing the right of the Holder to purchase the balance of the
Common Shares purchasable hereunder. Upon receipt by the Company of this
Warrant at the office of the Company or at the office of the Company's stock
transfer agent, in proper form for exercise and accompanied by the Purchase
Form and the Exercise Price, the Holder shall be deemed to be the holder of
record of the Common Shares issuable upon such exercise, notwithstanding that
the stock transfer books of the Company shall then be closed or


<PAGE>


that certificates representing such Common Shares shall not then be actually
delivered to the Holder.

         SECTION 2. RESERVATION OF SHARES. The Company hereby agrees that at
all times there shall be reserved for issuance and/or delivery upon exercise
of this Warrant such number of Common Shares as shall be required for
issuance or delivery upon exercise of this Warrant.

         SECTION 3. FRACTIONAL SHARES. No fractional shares or scrip
representing fractional shares shall be issued upon the exercise of this
Warrant. With respect to any fraction of a Common Share called for upon any
exercise hereof, the Company shall, upon receipt by the Company or the
Company's stock transfer agent of the Exercise Price on such fractional
share, pay to the Holder an amount in cash equal to such fraction multiplied
by the current market value of such fractional share, determined as follows:

                  (a) If the Common Shares are listed on a national securities
         exchange or a foreign exchange, are admitted to unlisted trading
         privileges on such an exchange or are listed for trading on a trading
         system of the National Association of Securities Dealers, Inc. ("NASD")
         such as The Nasdaq SmallCap Market ("SCM") or the Nasdaq National
         Market ("NNM") or the OTC Bulletin Board, then the current value shall
         be the last reported sale price of the Common Shares on such an
         exchange or system on the last business day prior to the date of
         exercise of this Warrant or if no such sale is made on such day, the
         average of the closing bid prices for the Common Shares for such day on
         such exchange or such system shall be used;

                  (b) If the Common Shares are not so listed on such exchange or
         system or admitted to unlisted trading privileges, the current value
         shall be the average of the last reported bid prices reported by the
         National Quotation Bureau, Inc. on the last business day prior to the
         date of the exercise of this Warrant; or

                  (c) If the Common Shares are not so listed or admitted to
         unlisted trading privileges and if bid prices are not so reported, the
         current value shall be an amount, not less than book value, determined
         in such reasonable manner as may be prescribed by the board of
         directors of the Company.

         SECTION 4. EXCHANGE, ASSIGNMENT OR LOSS OF WARRANT. This Warrant is
exchangeable, without expense, at the option of the Holder, upon presentation
and surrender hereof to the Company or at the office of its stock transfer
agent, if any, for other Warrants of different denominations entitling the
Holder thereof to purchase (under the same terms and conditions as provided
by this Warrant) in the aggregate the same number of Common Shares
purchasable hereunder. This Warrant may not be sold, transferred, assigned or
hypothecated except in compliance with federal and state securities laws. Any
transfer or assignment shall be made by surrender of this Warrant to the
Company or at the office of its stock transfer agent, if any, with the
Assignment Form annexed hereto duly executed and with funds sufficient to pay
any transfer tax; whereupon the Company shall, without charge, execute and
deliver a new Warrant in the name of the assignee named in such instrument of
assignment and this Warrant shall promptly be canceled. This Warrant may be
divided or combined with other Warrants which carry the same


                                       2
<PAGE>


rights upon presentation hereof at the office of the Company or at the office of
its stock transfer agent, if any, together with a written notice specifying the
names and denominations in which new Warrants are to be issued and signed by the
Holder hereof. The term "Warrant" as used herein includes any warrants issued in
substitution for or replacement of this Warrant or into which this Warrant may
be divided or exchanged. Upon receipt by the Company of evidence satisfactory to
it of the loss, theft, destruction or mutilation of this Warrant and (in the
case of loss, theft or destruction) of reasonably satisfactory indemnification,
and upon surrender and cancellation of this Warrant, if mutilated, the Company
will execute and deliver a new Warrant of like tenor and date. Subject to such
right of indemnification, any such new Warrant executed and delivered shall
constitute an additional contractual obligation on the part of the Company,
whether or not this Warrant so lost, stolen, destroyed or mutilated shall be at
any time enforceable by anyone.

         SECTION 5. RIGHTS OF THE HOLDER. The Holder shall not, by virtue
hereof, be entitled to any rights of a shareholder in the Company, either at
law or equity, and the rights of the Holder are limited to those expressed in
the Warrant and are not enforceable against the Company except to the extent
set forth herein.

         SECTION 6.   ADJUSTMENT PROVISIONS.

                  (a) ADJUSTMENTS OF THE EXERCISE PRICE.

                           (i) If the Company subdivides its outstanding Common
                  Shares into a greater number of Common Shares, the Exercise
                  Price in effect immediately prior to such subdivision shall be
                  proportionately reduced. Conversely, if the Company combines
                  its outstanding Common Shares into a lesser number of Common
                  Shares, the Exercise Price in effect immediately prior to such
                  combination -- shall be proportionally increased. In case of a
                  subdivision or combination, the adjustment of the Exercise
                  Price shall be made as of the effective date of the applicable
                  event. A distribution on Common Shares, including a
                  distribution of Convertible Securities, to shareholders of the
                  Company on a pro rata basis shall be considered a subdivision
                  of Common Shares for the purposes of this subsection (a)(i) of
                  this Section, except that the adjustment will be made as of
                  the record date for such distribution and any such
                  distribution of Convertible Securities shall be deemed to be a
                  distribution of the Common Shares underlying such Convertible
                  Securities.

                           (ii) If the Company shall at any time distribute or
                  cause to be distributed to its shareholders, on a pro rata
                  basis, cash, assets or securities of any entity other than the
                  Company, then the Exercise Price in effect immediately prior
                  to such distribution shall automatically be reduced by an
                  amount determined by dividing (x) the amount (if cash) or the
                  value (if assets or securities) of the holders of Warrants (as
                  such term is defined in the first paragraph hereof) pro rata
                  share of such distribution determined assuming that all
                  holders of Warrants had exercised their Warrants on the day
                  prior to such distribution, by (y) the number of



                                       3
<PAGE>


                  Common Shares issuable upon the exercise of Warrants (as such
                  term is defined in the first paragraph hereof) by the holders
                  thereof on the day prior to such distribution.

                  (b) NO ADJUSTMENT FOR SMALL AMOUNTS. Anything in this Section
         to the contrary notwithstanding, the Company shall not be required to
         give effect to any adjustment in the Exercise Price unless and until
         the net effect of one or more adjustments, determined as above
         provided, shall have required a change of the Exercise Price by at
         least one cent, but when the cumulative net effect of more than one
         adjustment so determined shall be to change the actual Exercise Price
         by at least one cent, such change in the Exercise Price shall thereupon
         be given effect.

                  (c) NUMBER OF SHARES ADJUSTED. Upon any adjustment of the
         Exercise Price, the Holder of this Warrant shall thereafter (until
         another such adjustment) be entitled to purchase, at the new Exercise
         Price, the number of Common Shares, calculated to the nearest full
         share, obtained by multiplying the number of Common Shares initially
         issuable upon exercise of this Warrant by the Exercise Price specified
         in the first paragraph hereof and dividing the product so obtained by
         the new Exercise Price.

                  (d) DEFINITIONS.

                           (i) Whenever reference is made in this Section to the
                  distribution of Common Shares, the term "Common Shares" shall
                  mean the Common Shares of the Company authorized as of the
                  date hereof and any other class of stock ranking on a parity
                  with such Common Shares. However, subject to the provisions of
                  Section (ii) hereof, Common Shares issuable upon exercise
                  hereof shall include only Common Shares of the class
                  designated as Common Shares of the Company as of the date
                  hereof.

                           (ii) Whenever reference is made in this Section to
                  the distribution of Convertible Securities, the term
                  "Convertible Securities" shall mean options or Warrants or
                  rights for the purchase of Common Shares of the Company or for
                  the purchase of any stock or other securities convertible into
                  or exchangeable for Common Shares of the Company.

                  (e) ANTIDILUTION PROVISIONS.

                           (i) ADJUSTMENTS OF EXERCISE PRICE. If the Company
                  should at any time or from time to time hereafter issue or
                  sell any of its Common Shares (other than Common Shares
                  outstanding on completion of the Company's private offering of
                  a maximum of 2,000,000 Common Shares pursuant to the Company's
                  Private Placement Memorandum dated July 3, 1997, as amended
                  February 1998 and Supplemented June 1998 ("Memorandum") and
                  other than Common Shares issued upon the conversion or
                  exercise of Convertible Securities or warrants and options
                  described in the Memorandum as outstanding or issuable)
                  without consideration or for a consideration per share less
                  than the Exercise Price in effect



                                       4
<PAGE>


                  immediately prior to the time of such issue or sale, then
                  forthwith upon such issue or sale, the Exercise Price shall be
                  automatically adjusted to a price (computed to the nearest
                  cent) determined by dividing (A) the sum of (x) the number of
                  Common Shares outstanding immediately prior to such issue or
                  sale multiplied by the Exercise Price in effect immediately
                  prior to such issue or sale and (y) the consideration, if any,
                  received by the Company upon such issue or sale, by (B) the
                  total number of Common Shares outstanding immediately after
                  such issue or sale. For purposes of this subsection (e)(i),
                  the following provisions (1) and (2) shall also be applicable:

                                    (1) RIGHTS, OPTIONS OR WARRANTS. In case at
                           any time hereafter the Company shall in any manner
                           grant any right to subscribe for or to purchase, or
                           any option or warrant for the purchase of Common
                           Shares or for the purchase of any stock or securities
                           convertible into or exchangeable for Common Shares
                           (such convertible or exchangeable stock or securities
                           being hereinafter referred to as the "Underlying
                           Convertible Securities") and if the minimum price per
                           share for which Common Shares are issuable, pursuant
                           to such rights, options, warrants or upon conversion
                           or exchange of such Underlying Convertible Securities
                           (determined by dividing (a) the total amount, if any,
                           received or receivable by the Company as
                           consideration for the granting of such rights,
                           options or warrants plus the minimum aggregate amount
                           of additional consideration payable to the Company
                           upon the exercise of such rights, options or warrants
                           under the terms of such rights, options or warrants
                           at the time of making such computation, plus, in
                           minimum aggregate amount of additional consideration,
                           if any, payable upon the conversion or exchange
                           thereof under the terms of such Underlying
                           Convertible Securities at the time of making such
                           computation, by (b) the total maximum number of
                           Common Shares issuable pursuant to such rights,
                           options or warrants or upon the conversion or
                           exchange of the total maximum amount of such
                           Underlying Convertible Securities issuable upon the
                           exercise of such rights, options or warrants under
                           the terms of such rights, options, warrants or
                           Underlying Convertible Securities at the time of
                           making such computation) shall be less than the
                           Exercise Price in effect immediately prior to the
                           time of the granting of such rights or options, then
                           the total maximum number of Common Shares issuable
                           pursuant to such rights, options, warrants or upon
                           conversion or exchange of the total maximum amount of
                           such Underlying Convertible Securities issuable upon
                           the exercise of such rights, options or warrants
                           under the terms of such rights, options warrants or
                           Underlying Convertible Securities at the time of
                           making such computation shall (as of the date of
                           granting of such rights, options or warrants) be
                           deemed to be outstanding and to have been issued for
                           said price per share as so determined, provided that
                           no further adjustment of the Exercise Price shall be
                           made upon the actual issue of Common Shares so deemed
                           to have been issued unless the price per share



                                       5
<PAGE>


                           received by the Company upon the actual issuance of
                           Common Shares so deemed to be issued differs from the
                           price per share which was last used to adjust the
                           Exercise Price or unless by the terms of such rights,
                           options or warrants or Underlying Convertible
                           Securities the price per share which the Company will
                           receive upon any such issuance of Common Shares
                           differs from the price per share which was last used
                           to adjust the Exercise Price, in either of which
                           events the Exercise Price shall be adjusted upon the
                           occurrence of either such event to reflect the new
                           price per share of Common Stock, and further provided
                           that, upon the expiration of such rights (including
                           rights to convert or exchange), options or warrants
                           (i) the number of shares of Common Stock deemed to
                           have been issued and outstanding by reason of the
                           fact that they were issuable pursuant to such rights,
                           options or warrants (including rights to convert or
                           exchange) that were not exercised shall no longer be
                           deemed to be issued and outstanding and (ii) the
                           Exercise Price shall forthwith be adjusted to the
                           price which would have prevailed had all adjustments
                           been made on the basis of the issue only of the
                           Common Shares actually issued upon the exercise of
                           such rights, options or warrants or upon conversion
                           or exchange of such Underlying Convertible
                           Securities. Such adjustments upon expiration shall
                           have no effect on Warrants exercised prior to such
                           expiration.

                                    (2) CONVERTIBLE SECURITIES. If the Company
                           shall in any manner issue or sell any Convertible
                           Securities other than the rights, options or warrants
                           described in subsection or (e)(i)(1) hereof and if
                           the minimum price per share for which Common Shares
                           are issuable upon conversion or exchange of such
                           Convertible Securities (determined by dividing (a)
                           the total amount received or receivable by the
                           Company as consideration for the issue or sale of
                           such Convertible Securities, plus the aggregate
                           amount of additional consideration, if any, payable
                           to the Company upon the conversion or exchange
                           thereof under the terms of such Convertible
                           Securities at the time of making such computation, by
                           (b) the total maximum number of Common Shares
                           issuable upon the conversion or exchange of all such
                           Convertible Securities under the terms of such
                           Convertible Securities at the time of making such
                           computation) shall be less than the Exercise Price in
                           effect immediately prior to the time of such issue or
                           sale, then the total maximum number of Common Shares
                           issuable upon conversion or exchange of all such
                           Convertible Securities at the time of making such
                           computation shall (as of the date of the issue or
                           sale of such Convertible Securities) be deemed to be
                           outstanding and to have been issued for said price
                           per share as so determined, provided that no further
                           adjustment of the Exercise Price shall be made upon
                           the actual issue of Common Shares so deemed to have
                           been issued unless the price per share received by
                           the Company upon the actual issuance of Common Shares
                           so deemed to be issued differs from the price per
                           share which was last used to adjust the Exercise
                           Price or unless by the terms of such



                                       6
<PAGE>


                           Convertible Securities the price per share which the
                           Company will receive upon any such issuance of Common
                           Shares differs from the price per share which was
                           last used to adjust the Exercise Price, in either of
                           which events the Exercise Price shall be adjusted
                           upon the occurrence of either such event to reflect
                           the new price per share of Common Shares, and further
                           provided that, if any such issue or sale of such
                           Convertible Securities is made upon exercise of any
                           right to subscribe for or to purchase or any option
                           to purchase any such Convertible Securities for which
                           an adjustment of the Exercise Price has been or is to
                           be made pursuant to the provisions of subsection
                           (e)(i)(1) then no further adjustment of the Exercise
                           Price shall be made by reason of such issue or sale
                           unless the price per share received by the Company
                           upon the conversion or exchange of such Convertible
                           Securities when actually issued differs from the
                           price which was last used to adjust the Exercise
                           Price or unless by the terms of such Convertible
                           Securities the price per share which the Company will
                           receive upon any such issuance of Common Shares upon
                           conversion or exchange of such Convertible Securities
                           differs from the price per share which was last used
                           to adjust the Exercise Price, in either of which
                           events the Exercise Price shall be adjusted upon the
                           occurrence of either of such events to reflect the
                           new price per share of Common Shares, and further
                           provided that, upon the termination of the right to
                           convert or to exchange such (i) the number of Common
                           Shares deemed to have been issued and outstanding by
                           reason of the fact that they were issuable upon
                           conversion or exchange of any such Convertible
                           Securities, which were not so converted or exchanged,
                           shall no longer be deemed to be issued and
                           outstanding, and (ii) the Exercise Price shall
                           forthwith be adjusted to the price which would have
                           prevailed had all adjustments been made on the basis
                           of the issue only of the number of Common Shares
                           actually issued upon conversion or exchange of such
                           Convertible Securities. Such adjustments upon
                           expiration shall have no effect on Warrants exercised
                           prior to such expiration.

                           (ii) DETERMINATION OF ISSUE PRICE. In case any Common
                  Shares or Convertible Securities shall be issued for cash, the
                  consideration received therefor, which shall be the gross
                  sales price for such security without deducting therefrom any
                  commission or other expenses paid or incurred by the Company
                  for any underwriting of, or otherwise in connection with, the
                  issuance thereof, shall be deemed to be the amount received by
                  the Company therefor. In case any Common Shares or Convertible
                  Securities shall be issued for a consideration part or all of
                  which shall be other than cash, then, for the purpose of this
                  subsection (e), the Board of Directors of the Company shall
                  determine the fair value of such consideration, irrespective
                  of accounting treatment, and such Common Shares or Convertible
                  Securities shall be deemed to have been issued for an amount
                  of cash equal to the value so determined by the Board of
                  Directors. The reclassification of securities other than
                  Common Shares into securities,



                                       7
<PAGE>


                  including Common Shares, shall be deemed to involve the
                  issuance for a consideration other than cash of such Common
                  Shares immediately prior to the close of business on the date
                  fixed for the determination of security holders entitled to
                  receive such Common Shares. In case any Common Shares or
                  Convertible Securities shall be issued together with other
                  stock or securities or other assets of the Company for
                  consideration, the Board of Directors of the Company shall
                  determine what part of the consideration so received is to be
                  deemed to be consideration for the issue of such Common Shares
                  or Convertible Securities.

                           (iii) DETERMINATION OF DATE OF ISSUE. In case the
                  Company shall take a record of the holders of Common Shares
                  for the purpose of entitling them (A) to receive a dividend or
                  other distribution payable in Common Shares or in Convertible
                  Securities or (B) to subscribe for or purchase Common Shares
                  or Convertible Securities, then such record date shall be
                  deemed to be the date of the issue or sale of the Common
                  Shares deemed to have been issued or sold upon the declaration
                  of such dividend or the making of such other distribution or
                  the date of the granting of such right of subscription or
                  purchase, as the case may be.

                           (iv) TREASURY SHARES. For the purpose of this Section
                  (f), Common Shares at any relevant time owned or held by, or
                  for the account of, the Company shall not be deemed
                  outstanding.

         SECTION 7. OFFICER'S CERTIFICATE. Whenever the Exercise Price shall be
adjusted as required by the provisions of Section 6 hereof, the Company shall
forthwith file in the custody of its Secretary or an Assistant Secretary at its
principal office and with its stock transfer and warrant agent, if any, an
officer's certificate showing the adjusted Exercise Price determined as herein
provided and setting forth in reasonable detail the facts requiring such
adjustment. Each such officer's certificate shall be made available at all
reasonable times for inspection by the Holder and the Company shall, forthwith
after each such adjustment, deliver a copy of such certificate to the Holder.

         SECTION 8. NOTICES TO HOLDERS. So long as this Warrant shall be
outstanding and unexercised (a) if the Company shall pay any dividend or make
any distribution upon the Common Shares, (b) if the Company shall offer to the
holders of Common Shares for subscription or purchase by them any shares of
stock of any class or any other rights or (c) if any capital reorganization of
the Company, reclassification of the capital stock of the Company, consolidation
or merger of the Company with or into another corporation, sale, lease or
transfer of all or substantially all of the property and assets of the Company
to another corporation or voluntary or involuntary dissolution, liquidation or
winding up of the Company shall be effected, then, in any such case, the Company
shall cause to be delivered to the Holder, at least 10 days prior to the date
specified in (x) or (y) below, as the case may be, a notice containing a brief
description of the proposed action and stating the date on which (x) a record is
to be taken for the purpose of such dividend, distribution or rights or (y) such
reclassification, reorganization, consolidation, merger, conveyance, lease,
dissolution, liquidation or winding up is to take place



                                       8
<PAGE>


and the date, if any is to be fixed, as of which the holders of Common Shares of
record shall be entitled to exchange their Common Shares for securities or other
property deliverable upon such reclassification, reorganization, consolidation,
merger, conveyance, dissolution, liquidation or winding up.

         SECTION 9. RECLASSIFICATION, REORGANIZATION OR MERGER. In case of any
reclassification, capital reorganization or other change of outstanding Common
Shares of the Company (other than a change in par value, from par value to no
par value, from no par value to par value or as a result of an issuance of
Common Shares by way of dividend or other distribution or of a subdivision or
combination) or in case of any consolidation or merger of the Company with or
into another corporation (other than a merger with a subsidiary in which merger
the Company is the continuing corporation and which does not result in any
reclassification, capital reorganization or other change of outstanding Common
Shares of the class issuable upon exercise of this Warrant) or in case of any
sale or conveyance to another corporation of the property of the Company as an
entirety or substantially as an entirety, the Company shall cause effective
provision to be made so that the Holder shall have the right thereafter, by
exercising this Warrant, to purchase the kind and amount of shares of stock and
other securities and property which the Holder would have received upon such
reclassification, capital reorganization or other change, consolidation, merger,
sale or conveyance had this Warrant been exercised prior to the consummation of
such transaction. Any such provision shall include provision for adjustments
which shall be as nearly equivalent as may be practicable to the adjustments
provided for in this Warrant. The foregoing provisions of this Section shall
similarly apply to successive reclassifications, capital reorganizations and
changes of Common Shares and to successive consolidations, mergers, sales or
conveyances. In the event the Company spins off a subsidiary by distributing to
the shareholders of the Company as a dividend or otherwise the stock of the
subsidiary, the Company shall reserve for the life of this Warrant shares of the
subsidiary to be delivered to the Holders of the Warrants upon exercise to the
same extent as if they were owners of record of the Warrant Shares on the record
date for distribution of the shares of the subsidiary.

         SECTION 10. REGISTRATION UNDER THE SECURITIES ACT OF 1933.

                  (a) Within 45 days after receipt of a written request by the
         then Holder(s) of Warrants or Warrant Shares representing at least 51%
         of the total Warrant Shares made at any time within the period
         commencing June 30, 1999 and ending June 30, 2003, the Company will
         file, no more than once, a registration statement under the Securities
         Act of 1933, as amended (the "Act"), registering the Warrants and the
         Warrant Shares. The Company will use its best efforts to cause such
         registration statement to become effective.

                  (b) In addition, if at any time during the period commencing
         June 30, 1999 and ending December 31, 2005, the Company should file a
         registration statement (which term shall not include any registration
         statement filed on Form S-8 or S-4) under the Act, which relates to a
         current offering of securities of the Company (except in connection
         with an offering (i) to employees or (ii) of the Company's securities
         solely in exchange for properties, assets or stock of other individuals
         or corporations), such registration



                                       9
<PAGE>


         statement and the prospectus included therein shall also, at the
         written request to the Company by any of the Holder(s) of the Warrants
         and Warrant Shares, relate to and meet the requirements of the Act with
         respect to any public offering of the Warrants and Warrant Shares so as
         to permit the public sale thereof in compliance with the Act. The
         Company shall give written notice to the Holder(s) of its intention to
         file a registration statement under the Act relating to a current
         offering of the aforesaid securities of the Company 30 or more days
         prior to the filing of such registration statement, and the written
         request provided for in the first sentence of this subsection shall be
         made by the Holder(s) 10 or more days prior to the date specified in
         the notice as the date on which it is intended to file such
         registration statement. Neither the delivery of such notice by the
         Company nor of such request by the Holder(s) shall in any way obligate
         the Company to file such registration statement, and, notwithstanding
         the filing of such registration statement, the Company may, at any time
         prior to the effective date thereof, determine not to proceed to
         effectiveness with such registration statement, without liability to
         the Holder(s).

                  (c) In addition, the Company will cooperate with the then
         Holder(s) of the Warrants and Warrant Shares in preparing and signing
         any registration statement, in addition to the registration statements
         discussed above, required in order to sell or transfer the Warrants and
         Warrant Shares and will sign and supply all information required
         therefor, but such additional registration shall be at cost and expense
         of the then Holder(s).

                  (d) When, pursuant to subsections (a), (b) or (c) of this
         Section, the Company shall take any action to permit a public offering
         or sale or other distribution of the Warrants and Warrant Shares, the
         Company shall:

                           (i) supply to each selling Holder a copy of the
                  registration statement and a reasonable number of copies of
                  the preliminary, final and other prospectus in conformity with
                  requirements of the Act and the Rules and Regulations
                  promulgated thereunder and such other documents as the Holders
                  shall reasonably request;

                           (ii) bear the complete cost and expense (other than
                  any selling commissions relating to the sale of the Warrants
                  and Warrant Shares, which shall be paid by the sellers
                  thereof) of such registrations or qualifications except those
                  filed under subsection (10)(c) which shall be cost and expense
                  of the Holder(s);

                           (iii) keep effective such registration statement
                  until the first of the following events occur (A) 12 months
                  have elapsed after the effective date of such registration
                  statement or (B) all of the registered Warrant Shares issued
                  by the Company either before or after the effective date of
                  such registration statement have been publicly sold under such
                  registration statement;

                           (iv) whenever the Company files a registration
                  statement pursuant to this Section that is declared effective
                  and that registers any Warrants or Warrant



                                       10
<PAGE>


                  Shares for resale, the Company agrees to use its best efforts
                  to register or qualify the Warrants and Warrant Shares for
                  sale in those states requested by the person selling the
                  Warrants or Warrant Shares, provided that the Company shall
                  not be required to register or qualify the Warrants and
                  Warrant Shares for sale in any state in which the sale of the
                  Warrants or Warrants Shares by the person selling the Warrants
                  or Warrant Shares would be exempt from having to be registered
                  or qualified in such state. The determination of whether or
                  not such an exemption exists shall be made by counsel for the
                  Company and such determination shall be provided in writing to
                  the person desiring to sell Warrants or Warrant Shares in a
                  state; and

                           (v) indemnify and hold harmless each such Holder and
                  each underwriter, within the meaning of the Act, who may
                  purchase from or sell for any such Holder, any Warrants or
                  Warrant Shares, from and against any and all losses, claims,
                  damages and liabilities (including, but not limited to, any
                  and all expenses whatsoever reasonably incurred in
                  investigating, preparing, defending or settling any claim)
                  arising from (A) any untrue or alleged untrue statement of a
                  material fact contained in any registration statement
                  furnished pursuant to subsection (i) or any prospectus
                  included therein or (B) any omission or alleged omission to
                  state therein a material fact required to be stated therein or
                  necessary to make the statements therein not misleading
                  (unless such untrue statement or omission or such alleged
                  untrue statement or omission was based upon information
                  furnished or required to be furnished in writing to the
                  Company by such Holder or underwriter expressly for use
                  therein), which indemnification shall include each person, if
                  any, who controls any such Holder or underwriter within the
                  meaning of the Act; provided, however, that the Company shall
                  not be so obligated to indemnify any such Holder or
                  underwriter or controlling person unless such Holder and
                  underwriter shall at the same time indemnify the Company, its
                  directors, each officer signing any registration statement or
                  any amendment to any registration statement and each person,
                  if any, who controls the Company within the meaning of the
                  Act, from and against any and all losses, claims, damages and
                  liabilities (including, but not limited to, any and all
                  expenses whatsoever reasonably incurred in investigating,
                  preparing, defending or settling any claim) arising from (1)
                  any untrue or alleged untrue statement of a material fact
                  contained in any registration statement or prospectus
                  furnished pursuant to subsection (i) or (2) any omission or
                  alleged omission to state therein a material fact required to
                  be stated therein or necessary to make the statements therein
                  not misleading, but the indemnity of such Holder, underwriter
                  or controlling person shall be limited to liability based upon
                  information furnished, or required to be furnished, in writing
                  to the Company by such Holder or underwriter or controlling
                  person expressly for use therein. The Company shall not be
                  liable for amounts paid in settlement of any such litigation
                  if such settlement was effected without the consent of the
                  Company. The indemnity agreement of the Company herein shall
                  not inure to the benefit of any such underwriter (or to the
                  benefit of any person who controls such underwriter) on
                  account of any losses, claims, damages



                                       11
<PAGE>


                  or liabilities (or actions or proceedings in respect thereof)
                  arising from the sale of any of such Warrants or Warrant
                  Shares by such underwriter to a person if such underwriter
                  failed to send or give a copy of the prospectus furnished
                  pursuant to subsection (i), as the same may then be
                  supplemented or amended (if such supplement or amendment shall
                  have been furnished to the Holders pursuant to said subsection
                  (i)), to such person with or prior to the written confirmation
                  of the sale involved.

                  (e) Each Holder shall supply such information as the Company
         may reasonably require from such Holder, or any underwriter for such
         Holders, for inclusion in such registration statement or posteffective
         amendment.

                  (f) The Company's agreements with respect to the Warrants and
         Warrant Shares in this Section will continue in effect regardless of
         the exercise or surrender of this Warrant.

                  (g) Any notices or certificates by the Company to the Holder
         and by the Holder to the Company shall be deemed delivered if in
         writing and delivered personally or sent by certified mail, return
         receipt requested, to the Holder, addressed to the Holder at the
         Holder's address as set forth on the Warrant or stockholder register of
         the Company, or, if the Holder has designated, by notice in writing to
         the Company, any other address, to such other address, and, if to the
         Company, addressed to it at 5600 South 42nd Street, Omaha, Nebraska
         67107. The Company may change its address by written notice to the
         Holder.

         SECTION 11. TRANSFER TO COMPLY WITH THE SECURITIES ACT OF 1933. The
Company may cause the following legend, or one similar thereto, to be set forth
on the Warrants and on each certificate representing Warrant Shares or any other
security issued or issuable upon exercise of this Warrant not theretofore
distributed to the public or sold to underwriters for distribution to the public
pursuant to Section 10 hereof, unless legal counsel for the Company is of the
opinion as to any such certificate that such legend, or one similar thereto, is
unnecessary:

         The securities represented by this certificate may not be offered for
         sale, sold or otherwise transferred except pursuant to an effective
         registration statement made under the Securities Act of 1933 (the
         "Act") and under any applicable state securities law, or pursuant to an
         exemption from registration under the Act and under any applicable
         state securities law, the availability of which is to be established to
         the satisfaction of the Company.

         SECTION 12. EXCHANGE PROVISIONS.

                  (a) For purposes of this Section, this Warrant shall be deemed
         to represent the same number of Warrants as there are Warrant Shares
         underlying this Warrant. For example, if there are 10,000 Warrant
         Shares underlying this Warrant, then for purposes of this Section, the
         Holder shall be deemed to hold 10,000 Warrants.



                                       12
<PAGE>


                  (b) For purposes of this Section, the following terms shall
         have the following meanings:

                           (i) "Current Market Value of a Warrant Share" shall
                  be the value of a Warrant Share as determined under subsection
                  (3)(a) or (b) hereof except that the time of the determination
                  thereunder shall be the last business day prior to the day the
                  Company receives a notice from the Holder under this Section.

                           (ii) "Warrant Value" shall mean the Current Market
                  Value of a Warrant Share minus or less the Exercise Price
                  payable under this Warrant as of the close of business on the
                  last business day prior to the day the Company receives a
                  notice from the Holder under this Section.

                  (c) The Holder shall have the right to exchange, in a cashless
         transaction, all or part of the Holder's Warrants for Common Shares
         issued by the Company at any time prior to the Expiration Date of such
         Warrants by providing written notice ("Notice") to the Company. Such
         Notice may only be provided after the earlier of the date the Company
         has received proceeds from the initial public offering by the Company
         pursuant to a registration statement declared effective under the Act
         or December 31, 1999, and only at a time when the Company's Common
         Shares are listed or approved for trading or quotation on a domestic or
         foreign exchange, interdealer trading system or national quotation
         bureau. Such Notice shall set forth the number of Warrants which the
         Holder elects to exchange for Common Shares.

                  (d) Within 10 days after receipt of such Notice by the
         Company, the Company shall issue the number of Common Shares of the
         Company to the Holder which is determined by dividing the Warrant Value
         of the Warrants being exchanged by the Current Market Value of a
         Warrant Share as of the date the Notice is received by the Company.

                  (e) The Holder shall surrender the Warrant which the Holder is
         exchanging for Common Shares upon receipt thereof. If the entire
         Warrant is being exchanged by the Holder for Common Shares, the Company
         shall cancel the entire Warrant. If less than the entire Warrant is
         being exchanged for Common Shares, the Company shall issue a new
         Warrant to the Holder representing the portion of this Warrant which
         was not exchanged for Common Shares.



                                       13
<PAGE>


         SECTION 13. APPLICABLE LAW. This Warrant shall be governed by, and
construed in accordance with, the laws of the State of Nebraska.

Dated:  [              ].

                                       TRANSGENOMIC, INC.



                                       By
                                         ---------------------------------------
                                       Name
                                           -------------------------------------
                                       Title
                                            ------------------------------------



                                       14
<PAGE>


                                  PURCHASE FORM


                                                   Dated: [__________], 19[___]

         The undersigned hereby irrevocably elects to exercise the Warrant to
the extent of purchasing [ ] shares of Common Shares and hereby makes payment of
$[ ] in payment of the actual exercise price thereof.

                     INSTRUCTIONS FOR REGISTRATION OF SHARES

Name:
     ---------------------------------------------------------------------------
                  (Please typewrite or print in block letters)

Address:
        ------------------------------------------------------------------------

Signature:
          ----------------------------------------------------------------------

                                 ASSIGNMENT FORM


                                                    Dated: [_________], 19[___]

FOR VALUE RECEIVED,
                   -------------------------------------------------------------

hereby sells, assigns and transfers unto
                                        ----------------------------------------

Name:
     ---------------------------------------------------------------------------
                  (Please typewrite or print in block letters)

Address:
        ------------------------------------------------------------------------

the right to purchase Common Shares represented by this Warrant to the extent of
Common Shares as to which such right is exercisable and does hereby irrevocably
constitute and appoint attorney to transfer the same on the books of the Company
with full power of substitution in the premises.


                                      Signature:



                                       15
<PAGE>


                                                                    EXHIBIT 10.3

                                    SCHEDULE
                                       OF
                                 WARRANT HOLDERS

<TABLE>
<CAPTION>

       --------------------------------------------- --------------------------------------------
                       NAME/ADDRESS                             NO. OF COMMON SHARES
       --------------------------------------------- --------------------------------------------
<S>                                                                   <C>
               SMITH HAYES FINANCIAL SVCS.                            108,250
              Consolidated Investment Corp.
                    200 Centre Terrace
                      1225 L Street
                    Lincoln, NE 68501
       --------------------------------------------- --------------------------------------------
                    Leroy J. Schroeder                                  2,500
                   800 US Bank Building
                    Lincoln, NE 68508
       --------------------------------------------- --------------------------------------------
       Section 1.        MILLENNIUM FINANCIAL GROUP                       500
                    Anthony H. Mannara
                     Via G. Cattori 3
                   6902 Lugano-Paradiso
                       Switzerland
       --------------------------------------------- --------------------------------------------
                       Namaste Ltd.                                     2,225
               P.O. Box 3338, 1225 Geneva 3
                       Switzerland
       --------------------------------------------- --------------------------------------------
                       Deltron Ltd.                                     2,225
                  Island Resources Ltd.
                  National House, Santon
                   Isle of Man IM4 1HA
       --------------------------------------------- --------------------------------------------
                    Michael R. Fugler                                     800
                 235 West 56th, Suite 37E
                    New York, NY 10019
       --------------------------------------------- --------------------------------------------
                     Shelley K. Gluck                                     250
                    3340 Indian Creek
                   Ft. Worth, TX 76180
       --------------------------------------------- --------------------------------------------
                     David M. Dobson                                      500
                  Via Santa Radegonda 16
                   20121 Milano, Italy
       --------------------------------------------- --------------------------------------------
                    Paolo E. Floriani                                     500
                      Via Cattori 3
                6902 Paradiso, Switzerland
       --------------------------------------------- --------------------------------------------
                     James M. McCrory                                     500
                      Viale Geno 16
                    22100 Como, Italy
       --------------------------------------------- --------------------------------------------
                     Frank T. Marino                                      500
                     32 Quai G. Ador
                   Geneva, Switzerland
       --------------------------------------------- --------------------------------------------
       Section 2.          RAF/AMERICAN FRONTEER                       16,850
                     John P. Kanouff
                  2525 East Cedar Avenue
                     Denver, CO 80209
       --------------------------------------------- --------------------------------------------

</TABLE>


                                       16
<PAGE>


<TABLE>
<CAPTION>

       --------------------------------------------- --------------------------------------------
<S>                                                                   <C>
                    Robert H. Taggart                                   3,370
              7163 S. Chapparal Circle East
                     Aurora, CO 80016
       --------------------------------------------- --------------------------------------------
       Section 3.            American Fronteer                          6,740
              Financial Corporation
                    One Norwest Center
             1700 Lincoln Street, 32nd Floor
                     Denver, CO 80203
       --------------------------------------------- --------------------------------------------
       Section 4.            American Fronteer                          6,740
              Financial Corporation
                    One Norwest Center
             1700 Lincoln Street, 32nd Floor
                     Denver, CO 80203
       --------------------------------------------- --------------------------------------------
       Section 5.          G.S. BECKWITH GILBERT                       300,000
                  G. S. Beckwith Gilbert
              Field Point Capital Management
                      47 Arch Street
                   Greenwich, CT 06830
</TABLE>


                                       17


<PAGE>

                                                                    EXHIBIT 10.4

                               TRANSGENOMIC, INC.

                           FIRST AMENDED AND RESTATED

                             SHAREHOLDERS AGREEMENT

         THIS AGREEMENT, originally entered into as of the 1st day of July,
1997, by and among TRANSGENOMIC, INC., a Delaware corporation (the
"Corporation"), and each of the holders of the Corporation's Common Stock as of
such date and such additional persons set forth in Schedule A hereto which
become a party hereto from time to time thereafter (collectively, the
"Shareholders") is hereby amended and restated as provided herein as of the 24th
day of February, 1998.

                              W I T N E S S E T H:

         WHEREAS, the Shareholders own all of the issued and outstanding shares
of Common Stock, par value $.01 per share, of the Corporation (the "Shares");
and

         WHEREAS, the Shareholders and the Corporation believe that it is in
their mutual best interest to impose certain restrictions and obligations upon
themselves and upon the transfer of the Shares;

         NOW, THEREFORE, in consideration of the premises and mutual covenants
set forth herein, it is mutually agreed by and among the parties as follows:

         SECTION 1. DEFINITIONS. As used in this Agreement, unless the context
otherwise requires:

                  "AGREEMENT" means this Shareholders' Agreement and any
         amendments and supplements hereto.

                  "BONA FIDE OFFER" means a written offer from a financially
         responsible party or parties identified therein by name and address,
         reasonably appearing able to comply with the terms of such offer, and
         accompanied by a deposit in an amount equal to or in excess of 10% of
         the purchase price. In the event that the person making such offer is a
         partnership or corporation, all general partners and all limited
         partners or shareholders owning more than 10% of its partnership
         interests or stock shall be identified.

                  "CONTROL SHAREHOLDER" means any Shareholder who, at the time
         in question, is a director or executive officer of the Corporation or
         who beneficially owns (as determined pursuant to Rule 13d-3 under the
         Securities Exchange Act of 1934) more than 10% of the issued and
         outstanding Shares.

                  "CORPORATION" means Transgenomic, Inc., a Delaware
         corporation.


<PAGE>


                  "EFFECTIVE DATE" means the date upon which a Notice of Offer
         is deemed to have been first delivered to the Corporation.

                  "NOTICE OF EXERCISE" means the written notice required to be
         given by the Corporation or a Shareholder to exercise the option to
         purchase the Shares offered for Transfer.

                  "NOTICE OF OFFER" means the written notice of a Shareholder's
         intention to Transfer any of his Shares and which sets forth the name
         of the proposed Transferee, the number of Shares to be Transferred and
         the terms and conditions of the proposed Transfer. Such notice shall be
         accompanied by a copy of a Bona Fide Offer received in connection with
         such proposed Transfer.

                  "PERMITTED TRANSFER" means a Transfer of Shares described in
         Section 5 hereof.

                  "PLACEMENT AGENTS" means RAF Financial Corporation and
         Millennium Financial Group, Inc.

                  "SECURITIES ACT" means the Securities Act of 1933, as amended
         from time to time, and the rules and regulations of the Securities and
         Exchange Commission promulgated thereunder.

                  "SELLING SHAREHOLDER" means any Shareholder who has delivered
         a Notice of Offer.

                  "SHAREHOLDERS" means the persons or entities which hold of
         record the issued and outstanding Shares of the Corporation.

                  "SHARES" means the issued and outstanding shares of the Common
         Stock, par value $.01 per share, of the Corporation.

                  "TRANSFER" means to directly or indirectly sell, assign,
         hypothecate, transfer, pledge, mortgage or in any other way encumber or
         dispose of Shares and shall be defined to include the process whereby
         Shares are transferred.

                  "TRANSFEREE" means the person or other entity to which a
         Selling Shareholder desires to Transfer Shares.

         SECTION 2. LEGEND. Each certificate representing Shares shall have the
following legend printed or typed thereon:

         THE SHARES OF STOCK REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN
         REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. SUCH SHARES
         HAVE BEEN ACQUIRED FOR INVESTMENT AND MAY NOT BE SOLD OR TRANSFERRED IN
         THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT WITH RESPECT THERETO
         UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR PURSUANT TO AN
         EXEMPTION


                                       2
<PAGE>


         FROM REGISTRATION UNDER THE ACT, THE AVAILABILITY OF WHICH IS TO BE
         ESTABLISHED TO THE SATISFACTION OF THE COMPANY.

         THE STOCK EVIDENCED BY THIS CERTIFICATE IS SUBJECT TO THE TRANSFER
         RESTRICTIONS CONTAINED IN A FIRST AMENDED AND RESTATED SHAREHOLDERS'
         AGREEMENT, DATED FEBRUARY[ ], 1998, BY AND AMONG THE CORPORATION AND
         ITS SHAREHOLDERS, A COPY OF WHICH IS ON FILE AT THE OFFICE OF THE
         CORPORATION. TRANSFERS IN VIOLATION OF THE SHAREHOLDERS' AGREEMENT ARE
         VOID. BY ACCEPTANCE OF THIS CERTIFICATE THE HOLDER HEREOF AGREES TO BE
         BOUND BY THE TERMS OF THE SHAREHOLDERS AGREEMENT.

All Shares hereafter issued shall bear the same legend.

         SECTION 3. RESTRICTIONS ON TRANSFER OF SHARES. No Shareholder shall
Transfer any Shares that he may now or hereafter hold, nor shall any such Shares
be transferable except in compliance with the terms of this Agreement. No
Transfer of Shares will be recognized by the Corporation unless a registration
statement relating thereto has been declared effective under the Securities Act
or the Selling Shareholder establishes to the satisfaction of the Company that
such Transfer of Shares is exempt from registration under the Securities Act and
applicable state securities laws.

         SECTION 4. RIGHTS OF FIRST REFUSAL.

               (a) No less than 20 days prior to any Transfer, other than a
          Permitted Transfer or a Transfer by a Shareholder under Section 6
          hereof, a Shareholder desiring to Transfer Shares shall furnish a
          Notice of Offer to the Corporation and to each other Shareholder. For
          a period of 10 days after the Effective Date thereof, the Corporation
          shall have an option to purchase all or any portion of the Shares
          offered for Transfer by the Selling Shareholder on the same terms and
          conditions as set forth in the Notice of Offer. If the Corporation
          elects to exercise such option, it must deliver to the Selling
          Shareholder a Notice of Exercise within 10 days of the Effective Date.

               (b) If the Corporation elects not to exercise said option for all
          of the Shares to be Transferred by the Selling Shareholder, then it
          shall give prompt notice thereof to the other Shareholders, after
          which the other Shareholders will have an option for an additional 10
          days to purchase all or any portion of the remaining Shares offered
          for Transfer by the Selling Shareholder on the same terms and
          conditions as set forth in the Notice of Offer. If a Shareholder
          elects to exercise its option to acquire Shares to be Transferred, it
          must deliver to the Selling Shareholder a Notice of Exercise within 20
          days of the Effective Date. If more than one Shareholder exercises
          said option, then each such Shareholders shall have the right to
          purchase Shares of the Selling Shareholder on a pro rata basis based
          on the current number of Shares owned by each purchasing Shareholder.


                                       3
<PAGE>


               (c) The Notice of Exercise delivered by the Corporation or any
          Shareholder shall specify a closing date within 35 days after the
          Effective Date of the Notice of Offer. The Selling Shareholder and the
          Corporation or other Shareholders, as the case may be, may extend the
          closing date by mutual written consent.

               (d) If either the Corporation or any Shareholder elects to
          exercise its option to purchase all or any portion of the Shares, then
          the Selling Shareholder may not Transfer such Shares to any other
          party. If the periods during which the Corporation and the other
          Shareholders are entitled to exercise their options to purchase such
          Shares expire without the exercise of said options with respect to any
          of the Shares so offered, then the Selling Shareholder shall, for a
          period ending 30 days after the termination of the last applicable
          option period, be free to Transfer the Shares to the Transferee making
          the Bona Fide Offer contained in the Notice of Offer or to another
          party or parties, but in either case only so long as such Transfer is
          effected on terms and conditions no less favorable to the Selling
          Shareholder as those set forth in the Bona Fide Offer contained in the
          Notice of Offer. Any Transferee shall, as a condition to the
          recognition by the Corporation of such Transfer, execute an instrument
          acceptable to the Corporation acknowledging the terms and restrictions
          of this Agreement and the Transferee's obligation to be bound hereby.

               (e) If the Selling Shareholder does not Transfer the Shares
          within the period specified in paragraph (d) hereof, then such Shares
          shall again become subject to the restrictions of this Agreement.

               (f) Any Shares purchased by the Corporation shall be restored to
          the status of authorized but unissued Shares.

               (g) The Selling Shareholder will be responsible for the payment
          of any and all expenses incurred by the Selling Shareholder in the
          exercise of the rights specified in this Section 4 and the sale of his
          Shares.

         SECTION 5. PERMITTED TRANSFERS.

               (a) The following types of Transfers ("Permitted Transfers") may
          be consummated notwithstanding the provisions of Section 4 of this
          Agreement:

                         (i) a Transfer by any Shareholder of all or any portion
                    of his Shares, whether or not for adequate consideration,
                    either directly to, or indirectly in trust for, his spouse,
                    children, parents, siblings or a corporation or other entity
                    of which he (and/or his spouse, children, parents or
                    siblings) beneficially own 100% of the equity interests;

                         (ii) a Transfer by any Shareholder of all or any
                    portion of his Shares to another Shareholder; or

                         (iii) a Transfer by any Control Shareholder of 50% or
                    more of his Shares.


                                       4
<PAGE>


               (b) In the event a Shareholder makes a Permitted Transfer, he
          shall notify the Corporation thereof, which notice shall specify (i)
          the name of the Transferee, (ii) the relationship of the Transferee to
          the Shareholder, (iii) the number of Shares transferred and (iv) the
          date of the Transfer. Any such Transferee shall, as a condition of the
          recognition by the Corporation of such Transfer, execute a counterpart
          copy of this Agreement or other instrument acceptable to the
          Corporation acknowledging the terms and restrictions of this Agreement
          and the Transferee's obligation to be bound hereby.

               (c) Notwithstanding any other provision of this Agreement, a
          Shareholder may pledge, hypothecate or otherwise encumber up to 50% of
          his Shares to, or in favor of, any national or state bank or other
          financial institution; provided, however, that a Shareholder may
          pledge, hypothecate or encumber all of his Shares in order to secure a
          loan made to the Company. In the event a Shareholder pledges,
          hypothecates or encumbers Shares, he shall notify the Corporation
          thereof, which notice shall specify (i) the name of the party to which
          the Shares have been pledged, (ii) the number of Shares pledged (iii)
          the amount of the obligation for which such Shares have been given as
          security and (iv) the date of the pledge.

         SECTION 6. SALES BY CONTROL SHAREHOLDERS.

               (a) Other than as provided in paragraph (b) of this Section 6,
          any Control Shareholder who agrees to sell more than 50% of his Shares
          shall, on behalf of each other Shareholder which desires to sell his
          Shares, cause the purchaser of the Control Shareholder's Shares to
          agree to also acquire the Shares of each such other Shareholder on the
          same terms as such purchaser has agreed to acquire the Shares from the
          Control Shareholder; provided, however, that if such purchaser is
          unwilling to buy all Shares tendered to it by such Control Shareholder
          and any such other Shareholders, then each of the selling Shareholders
          will be entitled to sell a pro rata portion of his Shares based on the
          current number of Shares owned by such Shareholder.

               (b) The provisions of Section 6(a) shall not apply to any sale of
          Control Shares from one Control Shareholder to another Control
          Shareholder.

               (c) Any sale of Shares pursuant to this Section 6 by Shareholders
          will not be subject to the provisions of Section 4 of this Agreement.

         SECTION 7. SECURITY FOR PURCHASE PRICE OF SHARES. Whenever any Shares
are purchased pursuant to the option created under Section 4 of this Agreement
and the parties agree that the entire purchase price for the Shares will not be
paid at closing, then the purchaser(s) may endorse the certificates for the
purchased Shares and deliver the same to the Selling Shareholder as collateral
security for the payment of the unpaid purchase price, and such shares may be so
held until the entire purchase price shall have been paid. While such shares
shall be so held as collateral security and so long as the purchasing
Shareholder is not in default, the purchasing Shareholder shall be entitled to
all rights as a Shareholder, including voting rights and rights to all
dividends, with respect to such Shares.


                                       5
<PAGE>


         SECTION 8. REGISTRATION RIGHTS.

               (a) If the Company proposes to file a registration statement
          under the Securities Act with respect to either a primary or secondary
          offering by the Company of equity securities for its own account
          (other than a registration statement relating solely to (i) securities
          to be offered to employees pursuant to a stock option, stock savings,
          or other employee benefit plan of the Company or its affiliates; (ii)
          securities proposed to be issued in exchange for securities or assets
          of, or in connection with a merger or consolidation with, another
          corporation; (iii) securities to be offered by the Company generally
          to any class or series of its then-existing security holders; (iv)
          ecurities issuable upon conversion of securities which are the subject
          of an underwritten redemption; or (v) securities to be offered or
          issued pursuant to a combination of the foregoing transactions), then
          the Company shall give written notice of such proposed filing to each
          Shareholder as soon as practicable (but in no event less than 30 days
          before the anticipated filing date of such registration statement),
          and such notice shall offer the opportunity to register all or any
          part of the Shares owned by the Shareholders. Shareholders shall have
          15 days following receipt of such notice to request in writing
          inclusion of their Shares in such registration, which request shall
          specify the number of Shares a Shareholder proposes to sell.

               (b) Whenever a Shareholder requests that all or part of his
          Shares be included in a proposed registration, the Company shall use
          its reasonable best efforts to effect the registration and sale of
          such Shares and to cause the managing underwriter of any proposed
          underwritten offering to permit the requested Shares to be included in
          such registration. Shareholders may only participate in the
          underwritten portion of such registration hereunder if each of them
          (i) agrees to sell their Shares on the basis provided in any
          underwriting arrangements and (ii) completes and executes all
          questionnaires, powers of attorney, indemnities, underwriting
          agreements and other documents reasonably required under the terms of
          such underwriting arrangements and these registration rights. Among
          other things, each Shareholder agrees, if his Shares are included in
          an underwritten offering, that he will join in any general agreement
          with the managing underwriter not to effect any public sale or
          distribution of his Shares pursuant to such registration for a period
          of time not to exceed 180 days after the date any such registration
          statement is declared effective under the Securities Act.

               (c) Notwithstanding anything else set forth in paragraph (a) of
          this Section 8, the Company may, at the discretion of a majority of
          its Board of Directors and without the consent of any requesting
          Shareholder, withdraw any registration and abandon the proposed
          offering. Furthermore, if the managing underwriter of an underwritten
          offering advises the Company that in its opinion either because of (i)
          the size of the offering that the Company and any Shareholders desire
          to make or (ii) the kind of securities that the Company and any
          Shareholders intend to include in such offering, the success of the
          offering could be materially and adversely affected by inclusion of
          the Shares requested to be included, then (A) in the event that the
          size of the offering is the basis of such managing underwriter's
          opinion, the amount of Shares to be offered for the account of
          Shareholders shall be reduced on a pro rata basis among such
          Shareholders (on the basis of the amount of Shares intended to be
          included in such registration by each such


                                       6
<PAGE>


         Shareholder as compared to the aggregate amount of Shares intended to
         be included by all such Shareholders) to the extent necessary to reduce
         the total amount of Shares to be included in such offering to the
         amount recommended by such managing underwriter; and (B) in the event
         that the kind or combination of securities to be offered is the basis
         of such managing underwriter's opinion, the amount of Shares to be
         included in such offering shall be reduced as described in clause (A)
         above or, if any such reduction would, in the judgment of the managing
         underwriter, be insufficient to substantially eliminate the adverse
         effect that inclusion of the Shares requested to be included could have
         on such offering, such Shares shall be excluded from such underwritten
         offering. Notwithstanding the exclusion of such Shares from such
         underwritten offering, the Company will cause such Shares to be
         registered for resale in the same registration statement, provided that
         the requesting Shareholders agree not to consummate any such resale of
         their Shares pursuant to such registration statement for a period of
         180 days after such registration statement is declared effective under
         the Securities Act. The Company agrees to maintain the effectiveness of
         such registration statement under the Securities Act for up to 12
         months after such 180-day period has expired or until all such
         registered Shares are sold.

               (d) The registration rights under this Section shall only apply
          to the first two registration statements filed by the Company and
          declared effective under the Securities Act, other than registration
          statements relating to those offerings described in items (i) through
          (v) of paragraph (a) of this Section 8.

               (e) The Company shall pay all expenses in connection with the
          registration of Shares pursuant to this Section 8, including expenses
          incurred in connection with any registration statements that do not
          become effective. Shareholders participating in such registration
          shall pay their pro rata share of all underwriting fees, discounts or
          commissions attributable to any sale of all or part of their Shares in
          connection with any registration, whether or not the registration
          statement becomes effective. A Shareholder's pro rata share of such
          underwriting fees, discounts or commissions will be determined by
          reference to the number of shares to be sold by such Shareholder
          compared with the number of shares to be sold by all Shareholders and
          the Company pursuant to the registration.

               (f) The Company agrees that, if a registration statement which
          would give rise to the registration rights set forth in paragraph (a)
          of this Section 8 has not been declared effective under the Securities
          Act on or before June 30, 1999, then it will use its best efforts to
          cause a registration statement to be filed on the appropriate form
          under the Securities Act which relates to the resale of the Shares and
          to have such registration statement declared effective under the
          Securities Act by no later than December 31, 1999; provided that such
          dates may be extended by mutual agreement between the Company and RAF
          Financial Corporation, in their sole discretion. The Company will keep
          the registration statement effective for 12 months after the 180-day
          period described in Section 8(c) hereof expires or until all
          registered shares have been sold, whichever occurs earlier. The
          Company further agrees that on the date such registration statement is
          declared effective, the Company will have caused the Shares to be
          listed on the New York Stock Exchange, if the Company qualifies for
          such listing or, if not, on the


                                       7
<PAGE>


         American Stock Exchange, if the Company qualifies for such listing or,
         if not, on the Nasdaq Stock Market, if the Company qualifies for such
         listing or, if not, on the SmallCap Market of The Nasdaq Stock Market.

               (g) Whenever the Company files a registration statement pursuant
          to this Section 8 that is declared effective and that registers any
          Shares for resale, the Company agrees to use its best efforts to
          register or qualify the Shares for sale in those states requested by
          the person selling the Shares; provided that, the Company shall not be
          required to register or qualify the Shares for sale in any state in
          which the sale of the Shares by the person selling the Shares would be
          exempt from having to be registered or qualified in such state. The
          determination of whether or not such an exemption exists shall be made
          by counsel for the Company and such determination shall be provided in
          writing to the person desiring the sell Shares in a state.

               (h) With respect to the Shareholders who purchased Shares in the
          private offering of up to 2,000,000 Shares (the "Private Offering")
          made by the Company pursuant to the Private Placement Memorandum,
          dated July 3, 1997, and any amendments or supplements thereto (the
          "PPM"), the Company agrees that it will issue additional Shares
          ("Additional Shares") to such Shareholders if (i) Shares are sold by
          the Company pursuant to the first registration statement of the
          Company which is declared effective under the Securities Act (other
          than those excluded registration statements described in Section 8(a)
          hereof) (the "Registered Offering") at a price of less than $10.00 per
          Share or (ii) Shares are sold by the Company between the date of the
          first sale of Shares in the Private Offering and the date of the
          closing of the Registered Offering at a price of less than $5.00 per
          Share; provided, however, that the Company will not be required to
          issue Additional Shares if the amount of consideration received by the
          Company from the issuance of shares (x) to the Placement Agents upon
          the exercise of the Placement Agent Warrants described in the PPM, (y)
          to G.S. Beckwith Gilbert upon the exercise of certain warrants issued
          by the Company to him or (z) to Jeffrey Sklar upon the exercise of
          certain options issued by the Company to him (all as described in the
          PPM) is less than $5.00 per share. If the sale price in the Registered
          Offering is less than $10.00 per Share, the number of Additional
          Shares to be issued to each such Shareholder will be determined by
          subtracting such sale price from $10.00, multiplying the result by the
          number of Shares acquired in the Private Offering by such Shareholder
          and then dividing the product by such sale price. If the sale price
          for any other sale of Shares described in clause (ii) above is less
          than $5.00 per Share, the number of Additional Shares to be issued to
          each such Shareholder will be determined by subtracting such sale
          price from $5.00, multiplying the result by the number of Shares
          acquired in the Private Offering by such Shareholder and dividing the
          product by such sale price. The Company will issue Additional Shares
          to each such Shareholder within 10 days after the date of the
          occurrence of the event that causes the Company to have to issue the
          Additional Shares. Further, such Additional Shares shall be subject
          to, and have the benefits of, this Agreement.

         SECTION 9. NOTICES. All notices, requests and other communications
hereunder, including a Notice of Offer, shall be in writing and shall be
delivered by courier or other means of personal service, national overnight
delivery service, telecopy, first class U.S. mail, postage prepaid, or


                                       8
<PAGE>


certified U.S. mail, return receipt requested, addressed (i) to the Corporation
at 5600 South 42nd Street, Omaha, Nebraska 68107, facsimile (402) 733-1264,
attention: Mr. Collin J. D'Silva or (ii) to a Shareholder at the address set
forth in Schedule A hereto or at such other address of which a Shareholder has
given the Corporation notice. All such notices shall be deemed to have been
delivered on the date personally delivered or telecopied, one business day after
being delivered to a national overnight delivery service or three business days
after being deposited in the U.S. Mail.

         SECTION 10. WAIVER. No waiver of any provision of this Agreement in any
instance shall be or for any purpose be deemed to be a waiver of the right of
any party hereto to enforce strict compliance with the provisions hereof in any
subsequent instance.

         SECTION 11. GOVERNING LAW. This Agreement shall be construed and
interpreted in accordance with the laws of the State of Delaware without giving
effect to its conflict of laws principals.

         SECTION 12. BINDING EFFECT AND BENEFITS. Except as otherwise provided
herein, the terms of this Agreement shall be binding upon and inure to the
benefit of the parties hereto and their respective heirs, executors,
administrators, personal representatives, successors and assigns, and shall be
binding upon any person to whom any of the Shares of the parties are transferred
and upon the heirs, executors, administrators, personal representative,
successors and assigns of each such person.

         SECTION 13. TERM OF AGREEMENT. This Agreement shall become effective as
of the date first written above and shall remain in full force and effect until
the Corporation and all of the Shareholders then holding Shares subject to this
Agreement shall agree in writing to its termination or until the first to occur
of (i) offering of Shares by the Corporation pursuant to a registration
statement effective under the Securities Act; provided that the provisions of
Section 8 shall remain in effect until satisfied, (ii) the purchase by one
Shareholder of all the issued and outstanding Shares of the Corporation or (iii)
the dissolution, bankruptcy or receivership of the Corporation. Upon termination
of this Agreement, the Secretary of the Corporation shall, upon tender of the
certificates for Shares, delete the legend endorsed thereon pursuant to Section
2 of this Agreement.

         SECTION 14. REMEDIES FOR VIOLATIONS. The Shares cannot be readily
purchased or sold on the open market and for this reason, among others, the
parties hereto will be irreparably damaged in the event that this Agreement is
not complied with by all parties hereto. In the event of any controversy
concerning the rights or obligations under this Agreement, such right or
obligation shall be enforceable in a court of equity by a decree of specific
performance.

         SECTION 15. ENTIRE AGREEMENT AND AMENDMENTS. This Agreement contains
the entire understanding and agreement between the parties hereto and supersedes
any prior agreements among the parties pertaining to the Shares. There are no
representations, warranties, promises, covenants or understandings other than
those herein expressly set forth. No change, modification or amendment of this
Agreement shall be valid unless the same be in writing and signed by all the
parties hereto.


                                       9
<PAGE>


         SECTION 16. SEVERABILITY. The invalidity or unenforceability of any
particular provision of this Agreement shall not affect the other provisions of
this Agreement, and this Agreement shall be construed in all respects as if such
invalid or unenforceable provision were omitted.

         SECTION 17. SECTION AND OTHER HEADINGS. The section and other headings
contained in this Agreement are for reference purposes only and shall not affect
the interpretation of this Agreement.

         SECTION 18. COUNTERPARTS. This Agreement may be executed in one or more
counterparts, each of which shall be deemed an original and all of which
together shall constitute one and the same instrument.

         SECTION 19. CONSTRUCTION. Whenever required by the context, references
herein to the singular shall include the plural and the masculine gender shall
include the feminine gender.

         SECTION 20. ADDITIONAL PARTIES. With the approval of the Corporation,
anyone in whose name Shares are registered may become a party to this Agreement
by executing a duplicate copy hereof.


                                       10
<PAGE>


         IN WITNESS WHEREOF, the parties have executed this Agreement as of the
date first above written.

                               TRANSGENOMIC, INC.

                               By  /s/ Collin J. D'Silva
                               -----------------------------------------------
                                   Collin J. D'Silva, President

                               SHAREHOLDERS

                               /s/ Collin J. D'Silva
                               -----------------------------------------------
                               Collin J. D'Silva, Shareholder

                               /s/ Collin J. D'Silva
                               -----------------------------------------------
                               Collin J. D'Silva, as trustee for the Arther P.
                               D'Silva Family Irrevocable Trust, Shareholder

                               /s/ Arther P. D'Silva
                               -----------------------------------------------
                               Arther P. D'Silva, Shareholder


                                       11
<PAGE>


                            /s/ Thomas E. Bowman
                            -----------------------------------------------


                            /s/ Una N. Bowman
                            -----------------------------------------------
                            Thomas E. Bowman and Una N. Bowman, Shareholder


                            /s/ Stephen F. Dwyer
                            -----------------------------------------------
                            Stephen F. Dwyer, Shareholder

                            /s/ Nancy Dwyer
                            -----------------------------------------------
                            Nancy Dwyer, Shareholder

                            /s/ Robert V. Dwyer
                            -----------------------------------------------
                            Robert V. Dwyer, Jr., Shareholder

                            /s/ Robert Sanger
                            -----------------------------------------------
                            Robert Sanger, as trustee for the Robert & Ellen
                            Sanger Trust Agreement of 1992, Shareholder

                            /s/ Douglas Gjerde
                            -----------------------------------------------
                            Douglas Gjerde, Shareholder

                            COROB Investments, Ltd., Shareholder by:
                            Name /s/ Robert V. Dwyer, Jr.
                                 -----------------------------------------------
                            Title    General Partner
                                 -----------------------------------------------

                            Each of the additional Shareholders listed in
                            Schedule A  hereto  by  Collin J.  D'Silva,
                            Attorney-in-fact

                            By  /s/ Collin J. D'Silva
                                ------------------------------------------------
                                Collin J. D'Silva, Attorney-in-fact

                                       12


<PAGE>

                                                                    EXHIBIT 10.5


                                                                   EXECUTION (I)

                               TRANSGENOMIC, INC.

                             SUBSCRIPTION AGREEMENT

         THE SECURITIES WHICH ARE THE SUBJECT OF THIS SUBSCRIPTION
         AGREEMENT HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF
         1933, AS AMENDED (THE "SECURITIES ACT"), OR UNDER THE LAWS OF
         ANY STATE OR OTHER JURISDICTION. THEY MAY NOT BE OFFERED OR
         SOLD UNLESS THEY ARE REGISTERED UNDER THE ACT AND UNDER THE
         LAWS OF THE STATES WHERE EACH SALE IS MADE, OR AN EXEMPTION
         FROM REGISTRATION REQUIREMENTS IS AVAILABLE IN THE OPINION OF
         COUNSEL SATISFACTORY TO THE COMPANY.

Investors Listed on Exhibit A Hereto
At The Addresses Listed Thereon

         Each of you (each a "Subscriber" and, collectively, the "Subscribers")
hereby agrees to purchase, and Transgenomic, Inc., a Delaware corporation (the
"Company") hereby agrees to issue and to sell to each Subscriber, a convertible
subordinated note of the Company in the principal amount set forth beside such
Subscriber's name on EXHIBIT A and in the form annexed as EXHIBIT B (the
"Note"), convertible in accordance with the terms thereof into shares (the
"Company Shares"; the Company Shares are sometimes referred to herein as the
"Shares") of the Company's Common Stock, $0.01 par value per share (the "Common
Stock"). Each Note, when issued to the Subscriber, will be one of a series of
Notes (the "Notes") issued to all Subscribers. The Notes and the Company Shares
are collectively referred to herein as, the "Securities." Upon acceptance of
this Agreement by the Subscriber, the Company shall issue and deliver to the
Subscriber a Note against payment, by wire transfer or bank cashier's check, of
the principal amount of the Note.

                  The following terms and conditions shall apply to this
subscription.

                          SUBSCRIBER'S REPRESENTATIONS AND WARRANTIES. Each
Subscriber, as and for itself, hereby represents and warrants to and agrees with
the Company that:

                          1.1 INFORMATION ON SUBSCRIBER. The Subscriber is
experienced in investments and business matters, has made investments of a
speculative nature and, with its representatives, has such knowledge and
experience in financial, tax and other business matters as to enable the
Subscriber to utilize the information made available by the Company to evaluate
the merits and risks of and to make an informed investment decision with respect
to the proposed purchase. The Subscriber has the authority and is duly and
legally qualified to purchase and own the Securities.


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 2

                  1.2 INVESTMENT INTENT. The Subscriber is subscribing for the
Securities for its own account and benefit and not as a nominee or for the
account of any other person or entity. The Subscriber has no present intention
of selling or distributing the Securities or any part thereof except for a sale
in accordance with applicable law. The Subscriber has sufficient financial
resources to hold the Securities for an indefinite period of time.

                  1.3 DILIGENCE. Such Subscriber has conducted its own due
diligence investigation of the Company, its business operations, prospects,
technologies, financial position and results of operations and all other aspects
thereof which are material to the undersigned's decision to purchase Notes. In
that regard, such Subscriber acknowledges that it and its representatives have
been given full and complete access to all material information regarding the
Company and has utilized such access to such Subscriber's satisfaction for the
purpose of obtaining information necessary to allow it to evaluate the merits
and risk of purchasing Notes. [Such Subscriber has either attended or been given
reasonable opportunity to attend a meeting with representatives of the Company
for the purpose of asking questions of, and receiving answers from, such
representatives concerning the Company and to the full satisfaction of such
Subscriber.

                  1.4 ACCREDITATION. Such Subscriber is an "accredited investor"
as defined in Rule 501 of Regulation D promulgated under the Securities Act of
1933, as amended (the "Securities Act") and has such knowledge and experience in
financial and business matters necessary to be capable of evaluating the merits
and risks of an investment in the Notes.

                  1.5 SIGNIFICANT RISK. Such Subscriber acknowledges that an
investment in the Company involves significant risks.

                  1.6 ABILITY TO BEAR ECONOMIC RISKS. Such Subscriber is able to
bear the economic risks of an investment in the Notes for an indefinite period
of time and is able to afford a complete loss of such investment.

                  1.7 NO PRIOR REGISTRATION. Such Subscriber acknowledges and
understands that the Notes have not been registered under the Securities Act
in reliance upon an exemption therefrom for nonpublic offerings and,
accordingly, the Notes will be restricted securities. Such Subscriber
acknowledges and agrees that (i) it will not sell, transfer or otherwise
dispose of any Notes without registration thereof under the Securities Act
and applicable state securities laws, or pursuant to an exemption therefrom
and (ii) the Company is under no obligation to register the Notes under such
securities laws subject to the registration rights set forth elsewhere in
this Agreement.

                           COMPANY REPRESENTATIONS AND WARRANTIES. The Company
represents and warrants to each Subscriber that:

                           2.1 DUE INCORPORATION; SUBSIDIARIES. The Company has
been duly incorporated and is validly existing as a corporation in good standing
under the laws of Delaware and is duly qualified and in good standing in each
other jurisdiction in which its properties or the nature of its business makes
such qualification necessary. The Company has no equity


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 3

investments in any other corporation or in any limited liability company,
partnership, joint venture or other entity, except for its subsidiary in the
United Kingdom, a foreign sales corporation, and a subsidiary in the Netherlands
which has ceased operations and is in the process of being dissolved.

                           2.2 OUTSTANDING STOCK. All issued and outstanding
shares of capital stock of the Company have been duly authorized and validly
issued and are fully paid and non-assessable. The authorized capital stock of
the Company immediately upon consummation at the Closing of the transactions
contemplated by this Agreement shall consist of 30,000,000 shares of Common
Stock, par value $0.01 per share, of which 13,000,000 shares shall have been
validly issued and be outstanding, fully paid and nonassessable, with no
personal liability attaching to the ownership thereof, and 15,000,000 shares of
preferred stock, par value $0.01 per share, of which no shares are issued and
outstanding.

                           2.3 AUTHORITY; ENFORCEABILITY. Each of this Agreement
and each Note have been duly authorized, executed and delivered by the Company
and each is a valid and binding agreement enforceable in accordance with its
terms, subject to bankruptcy, insolvency, fraudulent transfer, reorganization,
moratorium and similar laws of general applicability relating to or affecting
creditors' rights generally and to general principles of equity; and the Company
has full corporate power and authority necessary to carry on its business as now
conducted and proposed to be conducted and to enter into and deliver this
Agreement and the Investors Rights Agreement with the Subscribers and certain
shareholders of the Company (the "Investors Rights Agreement") (collectively,
the "Documents") and to issue and deliver the Notes and to perform its
obligations hereunder and thereunder.

                           2.4 ADDITIONAL ISSUANCES. Except as provided in
SCHEDULE 2.4, there are no outstanding agreements or preemptive or similar
rights affecting the Company's capital stock and no outstanding rights, warrants
or options to acquire, or instruments convertible into or exchangeable for, or
agreements or understandings with respect to the sale or issuance of, any
shares of Common Stock or equity of the Company, except that the Company may
issue up to 4,000,000 shares of Common Stock (subject to adjustment in
certain cases) under its 1997 Amended and Restated Stock Option Plan and its
United Kingdom Stock Plan (the "Stock Option Plan"). The authorized and
non-issued options under the Stock Option Plan shall be sufficient for the
Company for the two years following the date hereof.

                           2.5 CONSENTS. No consent, approval, authorization or
order of any court, governmental agency or body or arbitrator having
jurisdiction over the Company, or any of its affiliates is required for
execution of the Documents or the Notes, including, without limitation, issuance
and sale of the Notes and the issuance of the Shares upon any conversion of the
Notes or the performance of obligations hereunder or thereunder.

                           2.6 NO VIOLATION OR CONFLICT. Assuming the
representations and warranties of the Subscriber in Section 1 hereof are true
and correct and the Subscriber complies with its obligations under the
Documents, and upon receipt of the waiver of any preemptive rights of Mr. G. S.
Beckwith Gilbert with respect to the Notes and the Conversion Shares (the
"Conversion Shares"), neither the sale of any Note, nor any conversion of any
Note, nor the


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 4

issuance of the Company Shares upon any conversion of any Note, nor the
execution, delivery or performance of its obligations thereunder or under this
Agreement by the Company will:

                                    (a) violate, conflict with, result in a
breach of, or constitute a default (or an event which with the giving of notice
or the lapse of time or both would be reasonably likely to constitute a default)
under() the certificate of incorporation of the Company, charter or bylaws of
the Company, or any of its affiliates,() any decree, judgment, order, law,
treaty, rule, regulation or determination applicable to the Company, or any of
its affiliates of any court, governmental agency or body, or arbitrator having
jurisdiction over the Company, or any of its affiliates or over the properties
or assets of the Company, or any of its affiliates,() the terms of any bond,
debenture, note or any other evidence of indebtedness, or any agreement, stock
option or other similar plan, indenture, lease, mortgage, deed of trust or other
instrument to which the Company, or any of its affiliates is a party or by which
the Company, or any of its affiliates is bound, or to which any of the
properties of the Company, or any of its affiliates is subject, or () the terms
of any "lock-up" or similar provision of any underwriting or similar agreement
to which the Company, or any of its affiliates is a party; or

                                    (b) result in the creation or imposition of
any mortgages, judgments, claims, liens, security interests, pledges, escrows,
charges or other encumbrance of any kind or character whatsoever
("Encumbrances") upon the Securities or any of the assets of the Company, or
any of its affiliates.

                           2.7 THE SECURITIES. The Company has reserved and
unissued shares of Common Stock (including the Shares) sufficient to permit the
conversion in full of the Notes. The Securities upon issuance:

                                    (a) are, or will be, free and clear of any
Encumbrances;

                                    (b) have been, or will be, duly and validly
authorized and on the date of issuance (hereinafter the "Closing Date") or the
Conversion Date as such term is defined in the Note (hereinafter the "Conversion
Date"), as the case may be, each Note and the Shares issuable upon conversion of
each Note will be duly and validly issued, fully paid and nonassessable;

                                    (c) will not, upon receipt of the waiver of
any preemptive rights of Mr. G. S. Beckwith Gilbert with respect to the Notes
and the Conversion Shares, have been issued or sold in violation of any
preemptive or other similar rights of the holders of any securities of the
Company; and

                                    (d) will not subject the holders thereof to
personal liability by reason of being such holders.

                           2.8 LITIGATION. Except as provided in SCHEDULE 2.8,
there is no pending or, to the best knowledge of the Company, threatened action,
suit, proceeding or investigation


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 5

before any court, governmental agency or body, or arbitrator having jurisdiction
over the Company, or any of its affiliates, that questions the validity of this
Agreement or, if adversely determined, would adversely affect the execution by
the Company or the performance by the Company of its obligations under this
Agreement, the business or business prospects of the Company, or the assets of
the Company.

                           2.9 FINANCIAL INFORMATION. (a) Attached hereto as
SCHEDULE 2.9 are the audited balance sheet and statement of operations of the
Company as of December 31, 1998, for the twelve-month period then ended and the
unaudited balance sheet, statement of operations and statement of cash flows of
the Company as of January 31, 1999, for the 1-month period then ended, and
February 28, 1999, for the 2-month period then ended (collectively, the
"Financial Statements"), accompanied by a certificate of the Chief Financial
Officer of the Company. The Financial Statements (i) are in accordance with
the books and records of the Company, (ii) present fairly the financial
condition and the results of operations of the Company as of the date and for
the period indicated and (iii) have been prepared in accordance with
generally accepted accounting principles consistently applied.

                                    (b) The books of account, records and work
papers of the Company up to the date hereof are in all material respects
complete and correct, have been maintained in accordance with good business and
accounting practices and accurately reflect in all material respects the basis
for the financial position and results of operation of the Company as set forth
in the Financial Statements. All financial projections of the Company delivered
to the Subscriber contain management's best estimates of the future business and
potential future business of the Company; PROVIDED, HOWEVER, that no assurances
are made that such projected results can be achieved.

                           2.10 ABSENCE OF UNDISCLOSED LIABILITIES. Except as
set forth on SCHEDULE 2.10 hereto, at December 31, 1998, (a) the Company had no
material liability of any nature (matured or unmatured, fixed or contingent)
which was not provided for or disclosed on the Balance Sheet and (b) all
liability reserves established by the Company and set forth on the Balance Sheet
were adequate for all such liabilities at that date. Except as set forth on
SCHEDULE 2.10 hereto, there were no loss contingencies (as such term is used in
Statement of Financial Accounting Standards No. 5 issued by the Financial
Accounting Standards Board in March 1975) which were not adequately provided for
on the Balance Sheet.

                           2.11 ABSENCE OF CHANGES. Except as set forth on
SCHEDULE 2.11 hereto, since March 1, 1999, there has not been (a) any material
adverse change in the financial condition, results of operations, assets or
liabilities of the Company, (b) any borrowing or agreement to borrow funds or
any liability or obligation of any nature whatsoever (contingent or otherwise)
incurred by the Company, other than current liabilities or obligations incurred
in the ordinary course of business, (c) any asset or property of the Company
made subject to a lien of any kind, (d) any waiver of any valuable right of the
Company, or the cancellation of any material debt or claim held by the Company,
(e) any payment of dividends on, or other distributions with respect to, or any
direct or indirect redemption or acquisition of, any shares of the capital stock
of the Company, or any agreement or commitment therefor, (f) any issuance of any
stock, bond or other security of the Company, or any agreement or commitment
therefor


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 6

(including, without limitation, options, warrants or rights or agreements or
commitments to purchase such securities or grant such options, warrants or
rights), (g) any mortgage, pledge, sale, assignment or transfer of any tangible
or intangible assets of the Company, except, with respect to tangible assets, in
the ordinary course of business, (h) any loan by the Company to any officer,
director, employee, consultant or shareholder of the Company, or any agreement
or commitment therefor (other than advances to such persons in the ordinary
course of business in connection with travel and travel related expenses),
(i) any damage, destruction or loss (whether or not covered by insurance)
affecting the assets, property, financial condition or results of operations
of the Company, (j) any extraordinary increase, direct or indirect, in the
compensation paid or payable to any officer, director, employee, consultant
or agent of the Company or (k) any change in the accounting methods,
practices or policies followed by the Company or any change in depreciation
or amortization policies or rates theretofore adopted.

<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 7

                           2.12
TITLE TO ASSETS, PROPERTIES AND RIGHTS. Except as set forth in SCHEDULE 2.12,
the Company has good and marketable title to all of its properties, interests in
properties and assets, real, personal, intangible or mixed, reflected on the
Balance Sheet (or not so reflected because not required to be reflected but
which are used or useful in the business of the Company) or acquired after March
1, 1999 (except inventory or other property sold or otherwise disposed of since
March 1, 1999, in the ordinary course of business and accounts receivable and
notes receivable paid in full subsequent to March 1, 1999), free and clear of
all Encumbrances except liens for current taxes not yet due and payable (or
similar liens).

                           2.13 INTELLECTUAL PROPERTY RIGHTS. The Company has
prepared and the Subscriber has received the material listed on SCHEDULE 2.13
with respect to the Company's intellectual property, and except as set forth on
SCHEDULE 2.13 hereto:

                                    (a) the Company, to the best of its
knowledge, owns, possesses, has the exclusive right to use, has the right to
bring actions for the infringement of, and, where necessary, has made timely and
proper application for, all its Intellectual Property Rights (as hereinafter
defined) used in or necessary for the conduct of its business or as presently
conducted or as proposed to be conducted, all of which Intellectual Property
Rights are identified on SCHEDULE 2.13 (collectively, the "Requisite Rights");

                                    (b) no royalties, honoraria or fees are
payable by the Company to other persons by reason of the ownership or use of the
Requisite Rights; and

                                    (c) no product, service or process
manufactured, marketed, sold or used, or proposed to be manufactured, marketed,
sold or used, by the Company violates, or will violate, any license or
infringes, or will infringe, any Intellectual Property Rights or assumed name of
another; and there is no pending or threatened claim or litigation against the
Company (nor does there exist any basis therefor) contesting the validity of or
right to use any of the foregoing, nor has the Company received any notice
that any of the Requisite Rights or the operation or proposed operation of
the Company's business conflicts, or will conflict, with the asserted rights
of others, nor does there exist any basis for any such conflict.

As used herein, the term "Intellectual Property Rights" means all industrial and
intellectual property rights, including, without limitation, patents, patent
applications, patent rights, trademarks, trademark applications, trade names,
service marks, service mark applications, copyrights, know-how, certificates of
public convenience and necessity, franchises, licenses, trade secrets,
proprietary processes and technology and formulae.

                           2.14 TAX MATTERS. Except as provided on SCHEDULE
2.14, the Company has filed or will have filed all Federal, state, local and
foreign tax returns which are required to be filed by it, and all such returns
are true, correct and complete. The Company had paid all taxes pursuant to such
returns or pursuant to any assessments received by it or which it is obligated
to withhold from amounts owing to any employee, creditor or third party. The
income tax returns of the Company have never been audited by any Federal, state,
local or foreign authorities. The


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 8

provisions for taxes on the Balance Sheet are sufficient for the payment of all
accrued and unpaid Federal, state, local and foreign taxes as of such date. The
Company has not waived any statute of limitations with respect to taxes or
agreed to any extension of time with respect to any tax assessment or
deficiency. The Company has never filed a consent pursuant to Section 341(f) of
the Internal Revenue Code of 1986, as amended (the "Code"), relating to
collapsible corporations.

                           2.15 ERISA PLANS AND CONTRACTS. (a) Except as set
forth in the Company's 401(K) plan attached on SCHEDULE 2.15 hereto, the Company
does not maintain nor is it a party to (or ever has maintained or was a party
to) any "employee welfare benefit plan", as defined in Section 3(l) of the
Employee Retirement Income Security Act of 1974, as amended ("ERISA"), or any
other written, unwritten, formal or informal plan or agreement involving direct
or indirect compensation other than workers' compensation, unemployment
compensation and other government programs, under which the Company, or any
affiliate of the Company have any present or future obligation or liability. The
Company does not maintain nor is it a party to (or ever has maintained or was a
party to) any "employee pension benefit plan," as defined in Section 3(2) of
ERISA, and the Company does not contribute (or has ever contributed) to any
"multiemployer plan" as defined in Section 3(37) of ERISA.

                                    (b) There is no contract, agreement, plan or
arrangement covering any employee or former employee of the Company that,
individually or collectively, could give rise to the payment of any amount that
would not be deductible by reason of Section 280G of the Code.

                                    (c) Except as provided on SCHEDULE 2.15,
there is no employment, severance or other similar contract, arrangement or
policy (written or oral) providing for insurance coverage (including any
self-insured arrangements), non-statutory workers' compensation, disability
benefits, supplemental unemployment benefits, vacation benefits, retirement
benefits, deferred compensation, profit-sharing, bonuses, stock options, stock
appreciation or other forms of incentive compensation or post-retirement
insurance, compensation or benefits entered into, maintained or contributed to
by the Company.

                           2.16 AGREEMENTS. Except as set forth on SCHEDULE 2.16
hereto, the Company to the best of its knowledge is not a party to any written
or oral contract not made in the ordinary course of business and, whether or not
made in the ordinary course of business, the Company is not a party to any
written or oral (a) contract with any labor union; (b) contract for the
employment of any officer, individual employee or other person on a full-time
basis or any contract with any person on a consulting basis; (c) bonus, pension,
profit-sharing, retirement, stock purchase, stock option, hospitalization,
medical insurance or similar plan, contract or understanding in effect with
respect to employees or any of them or the employees of others; (d) agreement or
indenture relating to the borrowing of money or to the mortgaging, pledging or
placement of a lien on any assets of the Company; (e) guaranty of any obligation
for borrowed money or otherwise; (f) lease or agreement under which the Company
is lessee of or holds or operates any property, real or personal, owned by any
other party; (g) lease or agreement under which the Company is lessor of or
permits any third party to hold or operate any property, real or personal, owned
or controlled by the Company; (h) agreement or other commitment for capital
expenditures in excess of $100,000, not reflected on the financial statements as
of February 28,


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 9

1999; (i) contract, agreement or commitment under which the Company is obligated
to pay any broker's fees, finder's fees or any such similar fees, to any third
party; (j) (except as disclosed in Section 2.2 hereof) contract, agreement or
commitment under which the Company has issued or may become obligated to issue,
any shares of capital stock of the Company, or any warrants, options,
convertible securities or other commitments pursuant to which the Company is or
may become obligated to issue any shares of its capital stock; or (k) any other
contract, agreement, arrangement or understanding which is material to the
business of the Company. The Company has furnished to the Subscribers true and
correct copies of all such agreements and other documents requested by the
Subscribers or the authorized representatives of the Subscribers.

                           2.17 LABOR RELATIONS; EMPLOYEES. The number of
employees of the Company is as set forth on SCHEDULE 2.17 hereto, and except as
provided in SCHEDULE 2.17 (a) The Company to the best of its knowledge is not
delinquent in payments to any of its employees, for any wages, salaries,
commissions, bonuses or other direct compensation for any services performed by
them to the date hereof or amounts required to be reimbursed to such employees,
(b) the Company is in compliance in all material respects with all applicable
laws and regulations respecting labor, employment and employment practices,
terms and conditions of employment and wages and hours, (c) there is no labor
strike, dispute, slowdown or stoppage actually pending or, to the best knowledge
of the Company, threatened against or involving the Company and (d) neither any
grievance which might have a material adverse effect on the Company or the
conduct of its business nor any arbitration proceeding arising out of or under
collective bargaining agreements is pending and no claim therefor has been
asserted.

                           2.18 EMPLOYMENT OF OFFICERS, EMPLOYEES AND
CONSULTANTS. Except set forth on SCHEDULE 2.18, to the best knowledge of the
Company, no third party may assert any valid claim against the Company, any
Subscriber or any of the Designated Persons (as hereinafter defined) with
respect to (a) the continued employment by, or association with, the Company, of
any of the present officers or employees of or consultants to the Company
(collectively, the "Designated Persons") or (b) the use, in connection with any
business presently conducted or proposed to be conducted by the Company and/or
any of the Designated Persons of any information which the Company, or any of
the Designated Persons would be prohibited from using under any prior agreements
or arrangements or any legal considerations applicable to unfair competition,
trade secrets or proprietary information.

                           2.19 NO DEFAULTS. Except as provided in SCHEDULE 2.19
hereto, the Company is not in default (i) under its certificate of incorporation
or by-laws, or any indenture, mortgage, lease, purchase or sales order, or any
other contract, agreement or instrument to which the Company is a party or by
which the Company or any of their respective properties is bound or affected or
(ii) with respect to any order, writ, injunction or decree of any court or any
Federal, state, municipal or other domestic or foreign governmental department,
commission, board, bureau, agency or instrumentality. There exists no condition,
event or act which constitutes, or which after notice, lapse of time or both,
would constitute, a default under any of the foregoing.


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 10

                           2.20 COMPLIANCE. Except as provided in SCHEDULE 2.20,
the Company (a) in carrying out its contemplated business has been and will be
in compliance in all material respects with all Federal, state, local and
foreign laws, ordinances, regulations and orders of a material nature applicable
to it, its business and the ownership of its assets and (b) has all Federal,
state, local and foreign governmental licenses and permits material to and
necessary in the conduct of its business and such licenses and permits are in
full force and effect, and, to the best knowledge of the Company, no
violations have been recorded in respect of any such licenses or permits and
no proceeding is pending or threatened to revoke or limit any thereof.

                           2.21 INSURANCE. Certain insurance policies
information is attached as SCHEDULE 2.21. All the insurable properties of the
Company are insured for the benefit of the Company, in amounts deemed adequate
by the Company, against all risks usually insured against by persons operating
similar properties in the localities in which such properties are located under
policies in effect and issued by insurers of recognized responsibility.

                           2.22 RELATED TRANSACTIONS. Except as set forth on
SCHEDULE 2.22 hereto, no current or former stockholder, director, officer or
employee of the Company, nor any "associate" (as defined in the rules and
regulations promulgated under the Securities Exchange Act of 1934, as amended
(the "Exchange Act")) of the Company, is presently, or since the inception of
the Company has been, directly or indirectly through his or its affiliation with
any other person or entity, a party to any transaction with the Company
providing for the furnishing of services by or to, or rental of real or personal
property from or to, or otherwise requiring cash payments to or by any such
person. For the purposes of this Agreement, a transaction of the type described
in this Section 2.22 is sometimes herein referred to as a "Related Transaction".

                           2.23 OFFEREES. Except as provided in SCHEDULE 2.23
hereto, the Company has not during the past 12 months offered any of its capital
stock, or any other securities, for sale to, or solicited any offers to buy any
of the foregoing from, or otherwise approached or negotiated in respect thereof,
in such a manner as to require any capital stock or other securities to be
registered under the Securities Act.

                           2.24 USE OF PROCEEDS. The net proceeds of the Note
received by the Company shall be used by the Company for general working capital
purposes as shall be determined by the Board of Directors after the date hereof.

                           2.25 OFFERING EXEMPTION. Assuming the accuracy of the
representations of the Subscribers, the offering and sale of the Note and the
Common Stock upon conversion of the Note, are each exempt from registration
under the Securities Act; and the aforesaid offering and sale is also exempt
from registration under applicable state securities and "blue sky" laws.


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 11

                           2.26 BROKERS. Except as set forth on SCHEDULE 2.26
hereto, neither the Company, nor any of the officers, directors, employees or
stockholders of the Company have employed any broker or finder in connection
with the transactions contemplated by this Agreement.

                           2.27 DISCLOSURE. Neither this Agreement nor any other
document, certificate, instrument or written statement furnished or made to the
Subscriber by or on behalf of the Company in connection with the transactions
contemplated hereby contains any untrue statement of a material fact or omits to
state a material fact necessary in order to make the statements contained herein
and therein not misleading. There is no fact which materially adversely affects,
or in the future may, insofar as the Company may reasonably foresee, materially
adversely affect, the business, operations, affairs, prospects, condition,
properties or assets of the Company which has not been set forth in this
Agreement or in the other documents, certificates, instruments or statements
furnished to the Subscriber by or on behalf of the Company.

                           2.28 KNOWLEDGE DEFINITION. As used in this Section 2,
the term "to the knowledge of" the Company shall mean and include the actual
knowledge of the Company and of any director or officer of the Company.

                           2.29 QUESTIONABLE PAYMENTS. Neither the Company,
director, officer, agent, employee, or other person associated with or acting on
behalf of the Company, nor any Stockholder has, directly or indirectly: used any
corporate funds for unlawful contributions, gifts, entertainment, or other
unlawful expenses relating to political activity; made any unlawful payment to
foreign or domestic government officials or employees or to foreign or domestic
political parties or campaigns from corporate funds; violated any provision of
the Foreign Corrupt Practices Act of 1977; established or maintained any
unlawful or unrecorded fund of corporate monies or other assets; made any false
or fictitious entry on the books or records of the Company; made any bribe,
rebate, payoff, influence payment, kickback, or other unlawful payment; or made
any bribe, kickback, or other payment of a similar or comparable nature, whether
lawful or not, to any person or entity, private or public, regardless of form,
whether in money, property, or services, to obtain favorable treatment in
securing business or to obtain special concessions, or to pay for favorable
treatment for business secured or for special concessions already obtained.

                           2.30. Y2K READINESS. The Company has attached its Y2K
readiness statement hereto as SCHEDULE 2.30.

                           2.31. CORRECTNESS OF REPRESENTATIONS. The Company
represents that the foregoing representations and warranties are true and
correct as of the date hereof and, unless the Company otherwise notifies the
undersigned prior to the Closing Date on which the undersigned purchases the
Note, shall be true and correct as of the Closing Date. The foregoing
representations and warranties shall survive the Closing Date.

<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 12

                           AFFIRMATIVE COVENANTS OF THE COMPANY. The Company
covenants and agrees with the Subscriber as follows:

                           3.1. ACCESS TO RECORDS. The Company shall afford to
each Subscriber and its employees, counsel and other authorized representatives
free and full access, upon reasonable advance notice, to all of the books,
records and properties of the Company and to all officers and employees of the
Company, for any reasonable purpose whatsoever. The Subscribers shall maintain
the confidentiality of any confidential and proprietary information so obtained
by it; PROVIDED, HOWEVER, that the foregoing shall in no way limit or otherwise
restrict the ability of the Subscriber or such authorized representatives to
disclose any such information concerning the Company which it may be required to
disclose (a) to its partners or limited partners to the extent required to
satisfy its fiduciary obligations to such persons (PROVIDED, that such partners
or limited partners shall agree to maintain the confidentiality of such
information) or (b) otherwise pursuant to or as required by law.

                           3.2 NON-COMPETE AND NON-DISCLOSURE CONFIDENTIALITY
AGREEMENTS. Each person who would be considered a key employee after the Closing
Date, as a condition of becoming an employee of the Company, will sign, deliver
and become bound by an agreement with the Company relating to non-competition
with the Company substantially in the form of EXHIBIT C hereto.

Each person employed or to be employed by the Company who has, is proposed to
have or may obtain access to confidential and proprietary information of the
Company after the Closing Date, as a condition of gaining such access, will
sign, deliver and become bound by an agreement with the Company relating to
non-disclosure of proprietary information substantially in the form of EXHIBIT D
hereto.

                           3.3. FINANCIAL REPORTS. The Company agrees to furnish
to each Subscriber the following:

                                    (a) MONTHLY STATEMENTS. As soon available
but not later than 30 days after the end of each month, an unaudited financial
report of the Company, which report shall be prepared in accordance with United
States generally accepted accounting principles consistently applied, and which
shall include the following:

                                            (i) a balance sheet of the Company
as of the last day of such monthly accounting period;

                                            (ii) a statement of operations for
such monthly accounting period, itemizing all revenues and expenses, and a
statement of cash flows for such monthly accounting period together with (A) a
cumulative statement of operations and a statement of cash flows from the first
day of the current year to the last day of such monthly accounting period; and
(B) a comparison between the actual figures for such monthly accounting period
and the comparable figures for the prior year.


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 13

                                    (b) ANNUAL AUDIT. As soon as available but
not later than 90 days after the end of each fiscal year of the Company,
financial statements of the Company, which shall include a statement of
operations, a statement of shareholders equity and a statement of cash flows for
such fiscal year and a balance sheet as of the last day thereof, each prepared
in accordance with United States generally accepted accounting principles
consistently applied, and accompanied by the report of nationally-recognized
independent certified public accountants.

                                    (c) MISCELLANEOUS. Promptly upon becoming
available (i) copies of all financial statements, reports, press releases,
notices, proxy statements and other documents sent by the Company to its
stockholders or released to the public and copies of all regular and periodic
reports, if any, filed by the Company with the Securities and Exchange
Commission ("SEC") or any securities exchange, (ii) any other material financial
or other material information available to management of the Company on a
timely basis and (iii) upon request, at any time prior to the completion of a
firm commitment underwritten public offering of the Common Stock of the
Company under the Securities Act, which results in aggregate net cash
proceeds to the Company of not less than $15,000,000 (a "Designated
Offering") copies of minutes of meetings of the Board of Directors of the
Company.

                                    (d) SUBSIDIARIES. If for any period the
Company shall have any subsidiary or subsidiaries whose accounts are
consolidated with those of the Company, then in respect of such period the
financial statements delivered pursuant to the foregoing Sections 3.3(a), 3.3(b)
and 3.3(c) shall be the consolidated and consolidating financial statements of
the Company and all such consolidated subsidiaries.

                           3.4. BUDGET AND OPERATING FORECAST. With respect to
each fiscal year of the Company beginning after December 31, 1999, the Company
shall prepare and submit to the Board of Directors no later than sixty (60)
days before the commencement of such fiscal year a budget (the "Budget") for
such fiscal year. The Budget shall be accepted as the Budget for such fiscal
year when it has been approved by a majority of the Board of Directors of the
Company. The Budget shall be reviewed Fby the Company periodically and all
changes therein and all material deviations therefrom shall be resubmitted to
the Board of Directors of the Company in advance and shall be accepted when
approved by, and the Company shall not make any such changes or material
deviations to or from the Budget without such prior approval of, a majority
of the Board of Directors of the Company.

                           3.5. SYSTEM OF ACCOUNTING. The Company shall maintain
a system of accounting established and administered in accordance with United
States generally accepted accounting principles, and will set aside on its books
all such proper reserves as shall be required by generally accepted accounting
principles.

                           3.6. BOARD OF DIRECTORS; MEETINGS; EXPENSES. In
accordance with the terms of the Investors Rights Agreement, the Board of
Directors shall consist of seven Directors and there shall be on the Board of
Directors a Director selected by the Subscribers and a right for


<PAGE>

SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 14

a certain Subscriber to attend Board meetings and receive materials distributed
to members of the Board of Directors in advance of any meeting of the Board of
Directors. The Company shall pay all reasonable travel expenses and other
out-of-pocket disbursements incurred by the Director selected by the Subscribers
and by any Subscriber observing any meeting in connection with attending
meetings of the Board of Directors of the Company.

                           3.7. RIGHT OF FIRST REFUSAL. (a) Subject to the
rights granted to G.S. Beckwith Gilbert, and except in the case of Excluded
Securities, the Company shall not issue, sell or exchange, agree to issue, sell
or exchange, or reserve or set aside for issuance, sale or exchange (i) any
shares of Common Stock, (ii) any other equity security of the Company, (iii) any
debt security of the Company which by its terms is convertible into or
exchangeable for any equity security of the Company or has any other equity
feature, (iv) any security of the Company that is a combination of debt and
equity, or (v) any option, warrant or other right to subscribe for, purchase or
otherwise acquire any equity security or any such debt security of the Company,
unless in each case the Company shall have first offered (an "Offer") to sell to
each Subscriber its pro rata share (based upon the Voting Power of the holders
of the Notes) of such securities, upon terms and conditions in all respects,
including without limitation unit price and interest rates, which are no less
favorable than to any other person or persons or more favorable to the Company,
which Offer by its terms shall remain open and irrevocable for a period of 30
days from the date it is delivered by the Company to the Subscribers.

                           (b) Notice of a Subscriber's intention to accept an
offer, in whole or in part, shall be evidenced by a writing signed by the
Subscriber and delivered to the Company prior to the end of the 30-day period of
such Offer (the "Notice of Acceptance"), setting forth such portion of the
Offered Securities as the Subscriber elects to purchase.

                           (c) In the event that a Notice of Acceptance is not
given by the Subscriber in respect of all the Offered Securities, the Company
shall have 90 days from the expiration of the foregoing 30-day period to sell
all or any part of such remaining Offered Securities not covered by such Notice
of Acceptance, if any, to any other person or persons, but only upon terms and
conditions in all respects, including, without limitation, unit price and
interest rates, which are no more favorable, in the aggregate, to such other
person or persons or less favorable to the Company than those set forth in the
Offer. Upon the closing, which shall include full payment to the Company, of the
sale to such other person or persons of all the remaining Offered Securities,
each Subscriber exercising its preemptive right hereunder shall purchase from
the Company, and the Company shall sell to each such Subscriber, the Offered
Securities covered by the Notice of Acceptance, if any, delivered to the Company
by the Subscribers, at the terms specified in the Offer.

                           (d) In each case, any Offered Securities not
purchased by the Subscriber or other person or persons in accordance with this
Section 3.7 may not be sold or otherwise disposed of until they are again
offered to the Subscriber under the procedures specified in this Section 3.7.


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 15

                           (e) As used herein, "Excluded Securities" shall mean:

                                    (i) the Notes;

                                    (ii) the shares of Common Stock to be issued
upon conversion of the Notes;

                                    (iii) Common Stock issued (A) pursuant to
the Stock Option Plan; or (B) to one or more options, grants or issuances that
are approved by a Special Majority of the Board of Directors; all of such plans,
options and grants shall be collectively referred to as the "Plans";

                                    (iv) Common Stock issued pursuant to any
warrant or option that was outstanding on the Original Issue Date of the first
Note issued by the Company or pursuant to the Company's Shareholder Agreement
as in effect on and as of the Original Issue Date of the first Note issued by
the Company;

                                    (v) Common Stock issued to (A) financial
institutions, or other sellers or lessors of property in connection with
borrowing or lease financing arrangements of the Company, provided that such
issuances or grants are approved by a Special Majority of the Board of Directors
or (B) 50,000 shares of Common Stock in connection with the real estate
transaction disclosed in SCHEDULE 2.22 hereto;

                                    (vi) an aggregate of up to $8,000,000 of
additional notes, on substantially similar terms and conditions as contained in
the Notes, to Galen & Associates and/or others, the proceeds of which will be
used by the Company substantially to repurchase Common Stock of the Company; and

                                    (vii) Common Stock issued in a Designated
Offering.

                           3.8. EMPLOYEE STOCK AND OPTION PLANS. The Company
shall not sell stock or issue stock options to employees, other than pursuant to
the Company's Stock Option Plan in effect as of the date hereof and the
Company's United Kingdom Stock Option Sub Plan currently being approved by the
Company and the Revenue Service of the United Kingdom or pursuant to a plan
approved by a Special Majority of the Board of Directors.

                           3.9. TERMINATION OF AFFIRMATIVE COVENANTS. The
provisions of this Section 3, and the obligations of the Company to the
Subscribers, shall terminate and be of no further force and effect as to any
Subscriber upon the earlier to occur of (a) the consummation of the Designated
Offering, or (b) the payment in full of such Subscriber's Note, with the
exception of Sections 3.1 and 3.3 which shall terminate and be of no further
force and effect as to any Subscriber upon the later to occur of (a) the
Designated Offering or (b) the payment or conversion, in full, of such
Subscriber's Note.


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 16

                  4. NEGATIVE COVENANTS. Except as set forth on SCHEDULE 4,
during such time as any Note remains outstanding, the Company will not take any
of the following actions without the prior written consent of the greater of (a)
75% of the Voting Power of the Notes ("Voting Power" of the holders of the
Notes shall mean the relative voting power of the Notes on an as-converted
basis) or (b) 1% more than the Voting Power held by all of the following
combined: Chancellor Private Capital Partners III, L.P., Citiventure 96
Partnership, L.P., Chancellor Private Capital Offshore Partners II, L.P.,
Chancellor Private Capital Offshore Partners I, C.V., and Drake & Co. for the
account of Citiventure III:

                           (a) Pay, set aside for payment or declare any
dividend or other distribution on any share of Common Stock or any shares of any
other class or series of stock;

                           (b) Authorize or issue, directly or indirectly, any
securities of the Company with a liquidation preference having a priority to
that of the Notes;

                           (c) Engage in any business other than the business of
the Company as described to the Subscribers the private placement memorandum
delivered to the Subscribers by the Company in the course of Subscribers' due
diligence prior to the Closing, which new business any member of the Board of
Directors of the Company expects may result in direct annual operating
expenditures of more than forty percent (40%) of the Company's audited operating
expenses for the immediately preceding fiscal year (operating expenses shall
consist of manufacturing operations, research and development, marketing and
sales, and administrative expenses);

                           (d) Apply any of its assets to the redemption,
retirement, purchase or other acquisition directly or indirectly, through
subsidiaries or otherwise, of any of its securities including, without
limitation, any shares of Common Stock, (i) except from employees of the Company
upon termination of employment or pursuant to the Company's rights of first
refusal or rights of repurchase, if any, (ii) except for the repurchase of
Common Stock of the Company with the proceeds of additional notes an aggregate
of up to $8,000,000, on substantially similar terms and conditions as contained
in the Notes, to Galen & Associates and/or others, (iii) or except for a Note
which is one of the Notes;

                           (e) Engage in any transaction with any affiliate of
the Company (as such term is defined in Rule 405 promulgated under the
Securities Act) other than the transactions disclosed in SCHEDULE 2.22 hereto;

                           (f) Amend or repeal any provision of, add any
provision to, or take any corporation action otherwise altering the Company's
Certificate of Incorporation or By-laws; or


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 17

                           (g) Liquidate or dissolve the Company.

                  5. REGISTRATION RIGHTS.

                           If the Company proposes to file a registration
statement under the Securities Act with respect to any offering by the Company
of equity securities either for its own account or for the account of any holder
of securities of the Company, then the Company shall register all of the
Conversion Shares.

                           (a) The Company shall effect the registration of the
Conversion Shares and cause the managing underwriter of any proposed
underwritten offering to permit the Conversion Shares to be included in such
registration. Subscribers may only participate in the underwritten portion of
such registration hereunder if each of them (i) agrees to sell their Conversion
Shares on the basis provided in any underwriting arrangements and (ii) completes
and executes all questionnaires, powers of attorney, indemnities, underwriting
agreements and other documents reasonably required under the terms of such
underwriting arrangements and these registration rights. Among other things,
each Subscriber agrees, if its Conversion Shares are included in an underwritten
offering, that it will join in any general agreement with the managing
underwriter not to effect any public sale or distribution of its Conversion
Shares pursuant to such registration for a period of time not to exceed 180 days
after the date any such registration statement is declared effective under the
Securities Act. The Company agrees to maintain the effectiveness of such
registration statement under the Securities Act for up to 36 months after such
180-day period has expired or until all such registered Conversion Shares are
sold. The Company shall provide each Subscriber with a copy of any registration
statement, each amendment or supplement thereto, and any prospectus contained
therein (as amended or supplemented).

                           (b) Notwithstanding anything else set forth in
paragraph (a) of this Section 5, the Company may, at the discretion of a
majority of its Board of Directors and without the consent of any requesting
Subscriber, withdraw any registration and abandon the proposed offering. In the
event that Conversion Shares are excluded from an underwritten offering, the
Company will cause such Conversion Shares to be registered for resale in the
same registration statement, provided that the requesting Subscriber agree not
to consummate any such resale of their Conversion Shares pursuant to such
registration statement for a period of 180 days after such registration
statement is declared effective under the Securities Act. The Company agrees to
maintain the effectiveness of such registration statement under the Securities
Act for up to 36 months after such 180-day period has expired or until all such
registered Conversion Shares are sold. The Company shall provide each Subscriber
with a copy of any registration statement, each amendment or supplement thereto,
and any prospectus contained therein (as amended or supplemented).

                  (c) The Company shall pay all Registration Expenses (as
hereinafter defined) in connection with the registration of Conversion Shares
pursuant to this Section 5, including Registration Expenses incurred in
connection with any registration statements that do not become effective. All
Selling Expenses (as hereinafter defined) relating to the sale of the


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 18

Conversion Shares shall be borne by the Subscribers, PRO RATA, based upon the
number of shares so registered. "Registration Expenses" shall mean all expenses,
except Selling Expenses, incurred by the Company in complying with this Section
5 including, without limitation, all registration, qualification and filing
fees, printing expenses, escrow fees, fees and disbursements of counsel for the
Company, blue sky fees and expenses, the expense of any special audits incident
to or required by any such registration, and the reasonable fees and expenses of
one counsel for all of the Subscribers. "Selling Expenses" shall mean all
underwriting discounts, selling commissions and stock transfer taxes applicable
to the securities registered by the Subscribers and all fees and disbursements
of any counsel for the Subscribers, except for the reasonable fees and expenses
of one counsel for all of the Subscribers.

                  Whenever the Company files a registration statement pursuant
to this Section 5 that is declared effective and that registers any Conversion
Shares for resale, the Company agrees to use its best efforts to register or
qualify the Conversion Shares for sale in those states requested by each
Subscriber selling the Conversion Shares; provided that, the Company shall not
be required to register or qualify the Conversion Shares for sale in any state
in which the sale of the Conversion Shares by the person selling the Conversion
Shares would be exempt from having to be registered or qualified in such state.
The determination of whether or not such an exemption exists shall be made by
counsel for the Company and such determination shall be provided in writing to
the Subscriber desiring the sell Conversion Shares in a state.

                           6. INDEMNIFICATION; CONTRIBUTION.

                           6.1 INDEMNIFICATION OF SUBSCRIBERS. The Company
agrees to indemnify, hold harmless, reimburse and defend Subscriber against any
claim, costs, expense, liability, obligation, loss or damage (including legal
fees) of any nature, incurred by or imposed upon Subscriber which results,
arises out of or is based upon (a) any misrepresentation by Company or breach of
any warranty by Company in this Agreement or in any Exhibits or Schedules
attached hereto; or (b) any breach or default in performance by Company of any
covenant or undertaking to be performed by Company hereunder.

                           6.2 INDEMNIFICATION OF THE COMPANY. Each Subscriber,
as and for itself, agrees to indemnify, hold harmless, reimburse and defend the
Company against any claim, costs, expense, liability, obligation, loss or damage
(including legal fees) of any nature, incurred by or imposed upon the Company
which results, arises out of or is based upon any breach by Subscriber of any
representation set forth in this Agreement or in any Exhibits or Schedules
attached hereto. The amount for which any Subscriber shall be liable to the
Company pursuant to the indemnification provided for in this Section 6.2
shall be limited to its investment in the Company.

                           6.3. CONTRIBUTION. If the indemnification provided
for in Section 6.1 or Section 6.2 hereof is held by a court of competent
jurisdiction to be unavailable to an indemnified party with respect to any loss,
claim, damage, liability or action referred to herein, then the indemnifying
party, in lieu of indemnifying such indemnified party hereunder, shall
contribute to the amounts paid or payable by such indemnified party as a result
of such loss,


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 19

claim, damage, liability or action in such proportion as is appropriate to
reflect the relative fault of the indemnifying party on the one hand and of the
indemnified party on the other in connection with the statements or omissions
which resulted in such loss, claim, damage, liability or action as well as any
other relevant equitable considerations. The relative fault of the indemnifying
party and of the indemnified party shall be determined by reference to, among
other things, whether the untrue or alleged untrue statement of a material fact
or the omission or alleged omission to state a material fact relates to
information supplied by the indemnifying party or by the indemnified party and
the parties' relative intent, knowledge, access to information and opportunity
to correct or prevent such statement or omission. No person guilty of a
fraudulent misrepresentation (within the meaning of Section 11(f) of the
Securities Act) shall be entitled to contribution from any person who is not
guilty of such fraudulent misrepresentation. Notwithstanding the foregoing, the
liability of each Subscriber hereunder shall be limited to its investment in the
Company.

                           6.4 INDEMNIFICATION PROCEDURE. In the event that any
legal proceedings shall be instituted or that any claim or demand shall be
asserted by any third party in respect of which payment may be sought by a party
under the provisions of this Section 6 (referred to in this Section 6 as the
"Indemnitee"), the Indemnitee shall promptly cause written notice of the
assertion of any claim of which it has knowledge which is covered by this
indemnity to be forwarded to the party from which indemnification under this
Section 6 will be sought (referred to in this Section 6 as the "Indemnitor").
Indemnitor shall have the right, at its option and at its own expense, to be
represented by counsel of its choice who must be reasonably satisfactory to
Indemnitee, and to defend against, negotiate, settle or otherwise deal with any
proceeding, claim or demand which relates to any loss, liability, damage or
deficiency resulting from a third-party claim or demand indemnified against
hereunder; provided, however, that no settlement shall be made without the prior
written consent of Indemnitee, which consent shall not be unreasonably withheld
or delayed; and, provided further, that Indemnitee may participate in any such
proceeding with counsel of its choice and at its own expense. To the extent
Indemnitor elects not to defend such proceeding, claim or demand and Indemnitee
defends against, settles or otherwise deals with any such proceeding, claim or
demand, which settlement may be made without the consent of Indemnitor,
Indemnitee will act reasonably and in accordance with its good faith business
judgment and such settlement shall be covered by the indemnification provisions
of this Section 6. The parties hereto agree to cooperate fully with each other
in connection with the defense, negotiation or settlement of any such legal
proceeding, claim or demand.

                  7. CONDITIONS PRECEDENT TO CLOSING. The obligation of the
Subscriber to purchase and pay for the Note at the Closing is subject to the
following conditions precedent:

                           7.1 INVESTORS RIGHTS AGREEMENT. An Investors Rights
Agreement (the "Investors Rights Agreement") among the Company, the Subscribers
and certain of the shareholders of the Company, in the form of EXHIBIT E hereto,
shall have been duly executed and delivered by the Company, the Subscribers and
such shareholders. In addition, the Company and such parties shall have complied
with all of the terms and conditions of the Intercreditor Agreement, including,
among other things, the placement of the legends required to be placed on
securities owned by such parties.


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 20

                           7.2 WAIVER OF G.S. BECKWITH GILBERT. A written waiver
by Mr. G.S. Beckwith Gilbert of any preemptive rights he may have with respect
to the transactions contemplated hereunder in form and substance satisfactory to
the Subscribers shall have been received by the Company.

                           7.3 OPINION OF COUNSEL. The Subscriber shall have
received from Kutak Rock, special counsel for the Company, its opinion addressed
to the Subscriber dated as of the Closing Date substantially in the form of
EXHIBIT F hereto.

                           7.4 CORPORATE ACTION. All corporate and other
proceedings to be taken and all waivers and consents approvals, qualifications
and/or registrations required to be obtained or effected in connection with the
issuance, sale, execution, delivery and performance of the Documents and the
transactions contemplated thereby, including, but not limited to, the issuance,
sale and delivery of the Note, shall have been taken, obtained or effected
(except for the filing of any notice subsequent to such Closing which may be
required under applicable state securities laws which, if required, shall be
filed on a timely basis as may be so required), and all documents incident
thereto shall be satisfactory in form and substance to the Subscriber. The
Subscriber shall have received all such originals or certified or other copies
of such documents as have been reasonably requested.

                           7.5 NON-COMPETE AND NON-DISCLOSURE CONFIDENTIALITY
AGREEMENTS. Each employee of the Company designated in SCHEDULE 7.6 (a "Key
Employee") shall have signed and delivered to the Company, and be bound by, an
agreement with the Company relating to non- competition with the Company
substantially in the form of EXHIBIT C hereto. Each employee of the Company who
has or is proposed to have access to confidential and proprietary information of
the Company shall have signed and delivered and be bound by, an agreement with
the Company relating to non-disclosure of proprietary information substantially
in the form of EXHIBIT D hereto.

                           7.6 INSURANCE. The Company shall have in effect
insurance as set forth on SCHEDULE 2.21 hereto, as well as key man insurance for
Collin D'Silva.

                  8. MISCELLANEOUS.

                           8.1 NOTICES. All notices or other communications
given or made hereunder shall be in writing and shall be deemed delivered the
day telecopied (with copy mailed by certified or registered mail, or overnight
courier) to the party to receive the same at its address set forth below or to
such other address as either party shall hereafter give to the other by notice
duly made under this Section 9.1: (i) if to the Company, to it at its address
and telecopy number for notices on the signature page hereof; and (ii) if to the
Subscriber, to the name, address and telecopy number for notices on EXHIBIT A
hereto. All such notices, requests, consents and other communications shall be
deemed to have been delivered (a) in the case of personal delivery or delivery
by telecopy, on the date of such delivery, provided such date is a business day;
otherwise on the next business day following such delivery, (b) in the case of
dispatch by nationally-recognized overnight courier, on the next business day
following such dispatch and (c) in the case of mailing, on the third business
day after the posting thereof.


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 21

                           8.2 FEES AND EXPENSES. The Company shall pay to Pavia
& Harcourt, special counsel to the Subscribers, its fees and disbursements for
services rendered to the Subscribers in preparing this Agreement and the other
documents required for the closing of the purchase of the Notes solely from the
proceeds of the Notes.

                           8.3 ENTIRE AGREEMENT; ASSIGNMENT. This Agreement
(together with all Exhibits and Schedules hereto) and the Note represent the
entire agreement between the parties hereto with respect to the subject matter
hereof and may be amended only by a writing executed by both parties. No right
or obligation of either party shall be assigned by that party without prior
notice to and the written consent of the other party.

                           8.4 EXECUTION. This Agreement may be executed in
counterparts by facsimile transmission, followed by delivery of an executed
original copy.

                           8.5. CHOICE OF LAW. It is the intention of the
parties that the laws of New York shall govern the validity of this Agreement,
the construction of its terms and the interpretation of the rights and duties of
the parties.

                           8.6. SUBMISSION TO JURISDICTION; CONSENT TO SERVICE
OF PROCESS. The Company hereby submits to the non-exclusive jurisdiction of the
United States District Court for the Southern District of New York and of any
New York State court sitting in The City of New York for purposes of all legal
proceedings which may arise hereunder. The Company irrevocably waives to the
fullest extent permitted by law, any objection which it may have or hereafter
have to the laying of the venue of any such proceeding brought in such a court,
any claim that any such proceeding brought in such a court has been brought in
an inconvenient forum and trial by jury. The Company hereby consents to process
being served in any such proceeding by the mailing of a copy thereof by
registered or certified mail, postage prepaid, to its address specified in the
signature page hereof or in any other manner permitted by law.


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 22

                  Please acknowledge your acceptance of the foregoing
Subscription Agreement by signing and returning a copy to the undersigned
whereupon it shall become a binding agreement between us.

                                             Very truly yours,

                                             TRANSGENOMIC, INC.

                                             By: /s/ Collin J. D'Silva
                                                 ----------------------------
                                             Dated: March 25, 1999
                                                          --
                                             ADDRESS FOR NOTICES:

                                             5600 South 42nd Street
                                             Omaha, Nebraska 68107
                                             Telecopy:   (402) 733-1264

SUBSCRIBERS:

CHANCELLOR PRIVATE CAPITAL PARTNERS III, L.P.

By:  CPCP Associates, L.P., its General Partner

         By:  INVESCO Private Capital Inc., its General Partner

         By: [illegible]
            ------------------------------------
         Its:
             ------------------------------------
         Title:
               ------------------------------------

CITIVENTURE 96 PARTNERSHIP, L.P.

By:  INVESCO Private Capital Inc., as Investment Adviser

         By: [illegible]
            ------------------------------------
         Its:
             ------------------------------------
         Title:
               ------------------------------------


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 23

CHANCELLOR PRIVATE CAPITAL OFFSHORE PARTNERS II, L.P.

By:  CPCP Associates, L.P., its General Partner

                  By: INVESCO Private Capital Inc., its General Partner

                  By: [illegible]
                      ------------------------------------------
                  Its:
                      ------------------------------------------
                  Title:
                        ------------------------------------------

CHANCELLOR PRIVATE CAPITAL OFFSHORE PARTNERS I, C.V.

By:  Chancellor KME IV Partner, L.P., its General Partner

                  By:  INVESCO Private Capital Inc., its General Partner

                  By: [illegible]
                      ------------------------------------------
                  Its:
                      ------------------------------------------
                  Title:
                       ------------------------------------------

DRAKE & CO. FOR THE ACCOUNT OF CITIVENTURE III

                  By: John A. Gianni
                      ------------------------------------------
                  Its: /s/ John A. Gianni
                      ------------------------------------------
                  Title: Partner, Drake & Co
                        ------------------------------------------

BERKELEY INVESTMENTS LIMITED

                  By: [illegible]
                      ------------------------------------------
                  Its:
                      ------------------------------------------
                  Title: Director
                        ------------------------------------------

DAYSTAR REALTY LIMITED

                  By: /s/ Ishwar C. Sani
                      ------------------------------------------
                  Its: Ishwar C. Sani
                      ------------------------------------------
                  Title: Director
                        ------------------------------------------


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 24

HAMBRECHT & QUIST CALIFORNIA

                  By: /s/ Robert N. Savoie
                      ------------------------------------------
                  Its: Tax Director, Attorney-in-Fact
                      ------------------------------------------

HAMBRECHT & QUIST EMPLOYEE VENTURE
FUND, L.P. II

By:   H&Q Venture Management, L.L.C., its General Partner

                  By: /s/ Robert N. Savoie
                      ------------------------------------------
                  Its: Tax Director, Attorney-in-Fact
                      ------------------------------------------

CASDIN LIFE SCIENCES PARTNERS, L.P.

By:    Casdin Capital Partners, LLC, its General Partner

                  By: /s/ Jeffrey W. Casdin
                      ------------------------------------------
                  Its: CEO
                      ------------------------------------------
CLSP/SBS I, L.P.

By:     Casdin Capital Partners, LLC, its General Partner

                  By: /s/ Jeffrey W. Casdin
                      ------------------------------------------
                  Its: CEO
                      ------------------------------------------
CLSP/SBS II, L.P.

By:     Casdin Capital Partners LLC, its General Partner

                  By: /s/ Jeffrey W. Casdin
                      ------------------------------------------
                  Its: CEO
                      ------------------------------------------

/s/ Rob Olan
- ------------------------------------------
ROB OLAN

/s/ Steve Elms
- ------------------------------------------
STEVE ELMS


<PAGE>


SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 25

/s/ Vivek Jain
- ------------------------------------------
VIVEK JAIN

/s/ Dennis Purcell
- ------------------------------------------
DENNIS PURCELL

/s/ John Rumsey
- ------------------------------------------
JOHN RUMSEY

/s/ George Montgomery
- ------------------------------------------
GEORGE MONTGOMERY
<PAGE>

SUBSCRIPTION AGREEMENT                                        TRANSGENOMIC, INC.
MARCH 23, 1999
PAGE 26

<TABLE>
                           EXHIBITS

      <S>                                       <C>
      Exhibit A.................................Subscribers
      Exhibit B.................................Form of Note
      Exhibit C.................................Non-Compete Agreement
      Exhibit D.................................Non-Disclosure Agreement
      Exhibit E.................................Investors Rights Agreement
      Exhibit F.................................Form of Opinion
</TABLE>


<PAGE>


                                    EXHIBIT A

Investor Name and Address                                             Investment
- --------------------------------------------------------------------------------

<TABLE>
<S>                                                  <C>
Chancellor Private Capital Partners III, L.P.        $   1,137,000.00
c/o INVESCO Private Capital, Inc.
1166 Avenue of the Americas
New York, New York 10036
Attention: Mark Radovanovich
Facsimile No.: (212) 278-9868

Citiventure 96 Partnership, L.P.                     $   4,881,000.00
c/o INVESCO Private Capital, Inc.
1166 Avenue of the Americas
New York, New York 10036
Attention: Mark Radovanovich
Facsimile No.: (212) 278-9868

Chancellor Private Capital Offshore                  $   1,872,000.00
Partners II, L.P.
c/o INVESCO Private Capital, Inc.
1166 Avenue of the Americas
New York, New York 10036
Attention: Mark Radovanovich
Facsimile No.: (212) 278-9868

Chancellor Private Capital Offshore                  $     175,000.00
Partners I, C.V
c/o INVESCO Private Capital, Inc.
1166 Avenue of the Americas
New York, New York 10036
Attention: Mark Radovanovich
Facsimile No.: (212) 278-9868

Drake & Co. for the account                          $   1,935,000.00
of Citiventure III
c/o INVESCO Private Capital, Inc.
1166 Avenue of the Americas
New York, New York 10036
Attention: Mark Radovanovich
Facsimile No.: (212) 278-9868
</TABLE>


<PAGE>


Investor Name and Address                                             Investment
- --------------------------------------------------------------------------------
<TABLE>

<S>                                        <C>
Berkeley Investments Limited               $   550,000.00
1180 Avenue of the Americas
Suite 1920
New York, New York 10036
Mr. Kishore Mirchandani
Facsimile No.: (212) 768-9414

Daystar Realty Limited                     $   250,000.00
34-09 Queens Boulevard
Third Floor
Long Island City, New York 11101
Attention: Mr. Suresh Sani
Facsimile No.: (718) 482-1380

Hambrecht & Quist California               $   120,000.00
1 Bush Street
San Francisco, California 94104
Attention: Lisa Chen
Facsimile No.: (415) 439-3807

Hambrecht & Quist Employee                 $   120,000.00
    Venture Fund, L.P. II
c/o  Hambrecht & Quist California
1 Bush Street
San Francisco, California 94104
Attention: Lisa Chen
Facsimile No.: (415) 439-3807

Casdin Life Sciences Partners. L.P.        $   590,000.00
c/o Casdin Capital Partners, LLC
230 Park Avenue
20th Floor
New York, New York 10169
Attention: Jeffrey W. Casdin
Facsimile No: (212) 207-1542

CLSP/SBS I, L.P.                           $   220,000.00
c/o Casdin Capital Partners, LLC
230 Park Avenue
20th Floor
New York, New York 10169
Attention: Jeffrey W. Casdin
Facsimile No: (212) 207-1542
</TABLE>


<PAGE>


Investor Name and Address                                             Investment
- --------------------------------------------------------------------------------
<TABLE>

<S>                                        <C>
CLSP/SBS II, L.P.                          $   90,000.00
c/o Casdin Capital Partners, LLC
230 Park Avenue
20th Floor
New York, New York 10169
Attention: Jeffrey W. Casdin
Facsimile No: (212) 207-1542

Steve Elms                                 $   10,000.00
c/o Hambrecht & Quist
230 Park Avenue
New York, New York 10169
Facsimile No.: (212) 207-1519

John Rumsey                                $   10,000.00
c/o  Hambrecht & Quist California
1 Bush Street
San Francisco, California 94104
Facsimile No.: (415) 439-3807

Rob Olan                                   $   10,000.00
c/o Hambrecht & Quist
230 Park Avenue
New York, New York 10169
Facsimile No.: (212) 207-1519

Vivek Jain                                 $   10,000.00
c/o Hambrecht & Quist
230 Park Avenue
New York, New York 10169
Facsimile No.: (212) 207-1519

Dennis Purcell                             $   10,000.00
 c/o Hambrecht & Quist
230 Park Avenue
New York, New York 10169
Facsimile No.: (212) 207-1519

George Montgomery                          $   10,000.00
c/o  Hambrecht & Quist California
1 Bush Street
San Francisco, California 94104
Facsimile No.: (415) 439-3807
</TABLE>


<PAGE>




EXECUTION (i)

CN - 000___                                                           EXHIBIT B
                               TRANSGENOMIC, INC.

                                CONVERTIBLE NOTE
                                ----------------

         THIS NOTE AND THE COMMON STOCK INTO WHICH IT IS CONVERTIBLE
         (COLLECTIVELY, THE "SECURITIES") HAVE NOT BEEN REGISTERED
         UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "SECURITIES
         ACT"), OR UNDER THE LAWS OF ANY STATE OR OTHER JURISDICTION.
         THE SECURITIES MAY NOT BE OFFERED OR SOLD UNLESS THEY ARE
         REGISTERED UNDER THE SECURITIES ACT AND UNDER THE LAWS OF THE
         STATES WHERE EACH SALE IS MADE, OR AN EXEMPTION FROM
         REGISTRATION REQUIREMENTS IS AVAILABLE IN THE OPINION OF
         COUNSEL SATISFACTORY TO THE COMPANY.

                  FOR VALUE RECEIVED, TRANSGENOMIC, INC., a Delaware corporation
(hereinafter called "Borrower"), hereby promises to pay to [INVESTOR, NAME AND
ADDRESS], Fax: (___) ___-____ (the "Holder") or order, without demand, the sum
of ______________ Dollars ($___________), with interest accruing at the
compounded annual rate of 6.0%, on March 25, 2002 (the "Maturity Date"). This
Note is one of a series of Notes issued pursuant to a subscription agreement by
and between the Borrower and the Holder dated the date hereof (the "Subscription
Agreement") the terms and conditions of which are hereby incorporated herein by
this reference. Any capitalized term used herein and not otherwise defined
herein shall have the meaning assigned to such term in the Subscription
Agreement.

                  The following terms shall apply to this Note:

                                    ARTICLE I

                     INTEREST AND DEFAULT RELATED PROVISIONS

                  1.1. DEFAULT INTEREST. From and after an Event of Default
occurring prior to the date of the completion of a firm commitment underwritten
public offering of the Common Stock of the Company under the Securities Act,
which results in aggregate net cash proceeds to the Company of not less than
$15,000,000 (a "Designated Offering"), a default interest rate of 8.0% per annum
shall apply to the amounts owed hereunder.

                  1.2. CONVERSION PRIVILEGES. The Conversion Privileges set
forth in Article II shall remain in full force and effect until all principal
and interest due and payable under this Note is paid in full.


<PAGE>


                  1.3.     INTEREST PAYMENTS; MATURITY PREMIUM.

                           (a) Borrower shall pay interest on the outstanding
principal amount of the Note upon conversion as set forth in Section 1.3(b)
hereof or upon repayment of this Note at or after the Maturity Date.

                           (b) Upon the completion of a Designated Offering, all
accrued and unpaid interest hereunder shall be added to the principal
outstanding hereunder and shall be converted into shares of Common Stock
pursuant to Article II hereof and with respect to all interest to accrue for the
remaining term of this Note, the interest rate hereunder shall be reduced by
forty percent (40%) (ex., the initial interest rate of 6.0% shall be reduced to
3.6%) and all interest to become due for the remainder of the term through the
Maturity Date shall be paid in shares of Common Stock of the Company at the
Conversion Price.

                           (c) Upon repayment at or after the Maturity Date
(other than a conversion), a premium (the "Maturity Premium") equal to ten
percent (10%) of the outstanding principal amount shall also be due and payable.

                                   ARTICLE II

                                CONVERSION RIGHTS

                  The Holder shall have the right to convert the principal
amount due under this Note into Shares of the Borrower's Common Stock as set
forth below.

                  2.1.     CONVERSION AFTER DESIGNATED OFFERING

                           (a) At any time at or after the consummation of a
Designated Offering and prior to the payment in full of all principal of the
Note, the Holder shall have the right to convert any outstanding and unpaid
principal of this Note into fully paid and nonassessable shares of Common Stock
of Borrower as such stock exists on the date of issuance of this Note, or any
shares of capital stock of Borrower into which such stock shall hereafter be
changed or reclassified (the "Common Stock") at the conversion price as defined
in Section 2.1(b) hereof (the "Conversion Price"), determined as provided
herein.

                           (b) Subject to adjustment as provided in Section 2.3
hereof, (i) if a Designated Offering is completed on or before September 25,
2000, the Conversion Price shall be the lesser of (A)$5.00 per share and (B)
fifty percent (50%) of the per share offering price to the public in the
Designated Offering; (ii) if a Designated Offering is completed between
September 25, 2000 and the Maturity Date, the Conversion Price shall be the
lesser of (A) $5.00 per share and (B) between thirty-five percent (35%) and
fifty percent (50%) of the per share offering price to the public in the
Designated Offering, calculated on a declining straight-line basis, through the
day on which the Designated Offering is completed during such period, calculated
on a 30 day per month basis (by way of example, in the event a Designated
Offering is completed on the day that is 150 days after September 25, 2000, the
percentage shall be 45.83% [50% - (15/540 x 150)]); and (iii) if a Designated
Offering is not completed on or before the Maturity Date, the Conversion Price
shall be $5.00 per share; PROVIDED, HOWEVER, in the event


<PAGE>


that upon completion of a Designated Offering after the Maturity Date,
thirty-five percent (35%) of the per share offering price to the public in the
Designated Public Offering is less than $5.00 per share, the Company shall issue
to the former Holders of Notes who converted to Shares at $5.00 per share, such
additional shares of Common Stock so as to reduce the Conversion Price to such
lesser amount.

                  2.2      CONVERSION PRIOR TO DESIGNATED OFFERING.

                           () If, prior to the consummation of a Designated
Offering, and prior to the payment in full of all principal of, and accrued
interest on, this Note, any of the following events occurs (each a "Trigger
Event"): (i) a merger or consolidation of the Borrower with or into another
corporation or entity such that the Borrower is not the surviving entity thereof
(a "Merger Event"), (ii) the conveyance of all or substantially all of the
assets of the Borrower to an unaffiliated entity (a "Sale Event"), (iii) a
"Change of Control" (as defined below) or (iv) the dissolution of the Borrower
or other event causing the final liquidation of its assets or winding up of its
business affairs of the Company (a "Liquidation Event"), notice of which shall
be delivered to the Holder, the Holder of this Note shall have the right to
elect to (I) receive payment in full of all principal of this Note and interest
earned thereon through the date of payment or (II) convert all outstanding and
unpaid principal of this Note, and all accrued but unpaid interest on this Note,
into a number of fully paid and nonassessable shares of Common Stock equal to
the greater of:

                                    (r) the number of shares derived by dividing
                  the outstanding and unpaid principal of this note and all
                  accrued but unpaid interest on this Note by $5.00; or

                                    (s) the number of shares having an aggregate
                  value (as determined below) equal to (A) 200% of the
                  outstanding and unpaid principal amount of this Note plus (B)
                  all accrued but unpaid interest on this Note.

For purposes of clause (s) above:

                                    (x) the per share value of Common Stock to
                  be issued to the Holder in a Merger Event shall equal the per
                  share amount of cash and the value of securities to be
                  received by holders of Common Stock as a result of such Merger
                  Event;

                                    (y) the per share value of Common Stock to
                  be issued to the Holder in a Sale Event or a Liquidation Event
                  shall equal the per share amount of cash that would be
                  distributed to the holders of Common Stock as a result thereof
                  assuming an immediate distribution of such cash after such
                  Sale Event or Liquidation Event; and

                                    (z) the per share value of the Common Stock
                  to be issued to the Holder in a Change of Control shall equal
                  the per share price paid for shares of Common Stock in the
                  last transaction that results in the occurrence of a Change of
                  Control.


<PAGE>


                           () The Holder shall have a period of no less than 30
days after Borrower delivers notice to any proposed Trigger Event in which to
make an election to convert this Note pursuant to this Section 2.2.

                           (c) In the case of a Merger Event, the shares to be
delivered upon conversion of this Note shall be shares of stock or other
securities of the successor to the Borrower that the Holder would have been
entitled to receive as a result of such Merger Event had the Holder converted
this Note to Common Stock of the Borrower immediately prior to such Merger
Event.

                           (d) For purposes of this Section 2.2, a "Change in
Control" shall occur at any time when the shareholders of the Borrower on the
Original Issue Date no longer beneficially own a majority of the issued and
outstanding voting securities of the Borrower.

                           (e) In addition to the other rights of a Holder prior
to a Designated Offering, in the event Collin D'Silva seeks to sell any Common
Shares owned by him, and Holder desires to exercise its rights under the Co-Sale
provision of Section 2 of the Investors Rights Agreement, dated as of the date
hereof among the Holders of the Notes, Collin D'Silva and the Company (the
"Investors Rights Agreement"). Holder may convert that portion of this Note at a
Conversion Price of $5.00 per share to obtain the number of Shares necessary for
the Holder to exercise its rights thereunder.

                  2.3.     ADJUSTMENTS TO CONVERSION PRICE FOR DILUTING ISSUES:

                           (a) SPECIAL DEFINITIONS. The following definitions
shall apply:

                                    (i) "OPTION" shall mean options, warrants or
other rights to subscribe for, purchase or otherwise acquire either Common Stock
or Convertible Securities.

                                    (ii) "ORIGINAL ISSUE DATE" shall mean, with
respect to any Note, the first date on which the first Note shall have been
issued.

                                    (iii) "CONVERTIBLE SECURITIES" shall mean
any evidences of indebtedness, shares (other than Common Stock) of capital stock
or other securities directly or indirectly convertible into or exchangeable for
Common Stock.

                                    (iv) "ADDITIONAL SHARES OF COMMON STOCK"
shall mean any or all shares of Common Stock issued (or, pursuant to Section
2.3(c), deemed to be issued) by the Company after the Original Issue Date, other
than shares of Common Stock issued or issuable:

                                            (1) upon conversion of shares of any
Note in accordance with this Article II;

                                            (2) to employees, officers or
directors of, or consultants to, the Company pursuant to (i) employee stock
purchase plans, stock option plans or the like that provide for the issuance of
such number of shares of Common Stock as are specified in such plan or plans at
such price per share as is specified therein, provided that each such plan
existed as of


<PAGE>


the Original Issue Date or has been approved by a majority of the Board of
Directors, including the director designated by the Holders of the Notes (a
"Special Majority"); or (ii) one or more options, grants or issuances that are
approved by a Special Majority of the Board of Directors; all of such plans,
options and grants shall be collectively referred to as the "Plans";

                                            (3) pursuant to any warrant or
option that was outstanding on the Original Issue Date of the first Note to be
issued; or

                                            (4) to financial institutions or
other sellers or lessors of property in connection with borrowing or lease
financing arrangements of the Company, provided that such issuances or grants
are approved by a Special Majority of the Board of Directors.

                           (b) NO ADJUSTMENT OF CONVERSION PRICE, Subject to the
provisions of Section 2.3(c)(ii) and Section 2.3(f) below, no adjustment in the
number of shares of Common Stock into which the Note is convertible shall be
made, by adjustment in the Applicable Conversion Price of the Note in respect of
the issuance of Additional Shares of Common Stock or otherwise, (i) unless the
consideration per share for an Additional Share of Common Stock issued or deemed
to be issued by the Company is less than the Applicable Conversion Price in
effect on the date of, and immediately prior to, the issue of such Additional
Share of Common Stock or (ii) if the holders of a majority of the Voting Power
of the Notes waive any such adjustment.

                           (c) ISSUE OF SECURITIES DEEMED ISSUE OF ADDITIONAL
SHARES OF COMMON STOCK.

                                    (i) OPTIONS AND CONVERTIBLE SECURITIES. In
the event the Company at any time or from time to time after the Original Issue
Date shall issue any Options or Convertible Securities or shall fix a record
date for the determination of holders of any class of securities entitled to
receive any such Options or Convertible Securities, then the maximum number of
shares (as set forth in the instrument relating thereto without regard to any
provisions contained therein for a subsequent adjustment of such number) of
Common Stock issuable upon the exercise of such Options or, in the case of
Convertible Securities and Options therefor, the conversion or exchange of such
Convertible Securities, shall be deemed to be Additional Shares of Common Stock
issued as of the time of such issue or, in case such a record date shall have
been fixed, as of the close of business on such record date, provided that such
Additional Shares of Common Stock shall not be deemed to have been issued unless
the consideration per share (determined pursuant to Section 2.3(e) hereof) of
such Additional Shares of Common Stock would be less than the Applicable
Conversion Price in effect on the date of and immediately prior to such issue,
or such record date, as the case may be, and provided further that in any such
case in which Additional Shares of Common Stock are deemed to be issued:

                                            (1) no further adjustment in the
Applicable Conversion Price shall be made upon the subsequent issue of
Convertible Securities or shares of Common Stock upon the exercise of such
Options or conversion or exchange of such Convertible Securities;


<PAGE>


                                            (2) if such Options or Convertible
Securities by their terms provide, with the passage of time or otherwise, for
any increase in the consideration payable to the Company, or decrease in the
number of shares of Common Stock issuable, upon the exercise, conversion or
exchange thereof, the Applicable Conversion Price computed upon the original
issue thereof (or upon the occurrence of a record date with respect thereto),
and any subsequent adjustments based thereon, shall, upon any such increase or
decrease becoming effective, be recomputed to reflect such increase or decrease
insofar as it affects such Options or the rights of conversion or exchange under
such Convertible Securities;

                                            (3) upon the expiration of any such
Options or any rights of conversion or exchange under such Convertible
Securities which shall not have been exercised, the Applicable Conversion Price
computed upon the original issue thereof (or upon the occurrence of a record
date with respect thereto), and any subsequent adjustments based thereon, shall
upon such expiration, be recomputed as if:

                                                      (A) in the case of
Convertible Securities or Options for Common Stock the only Additional Shares of
Common Stock issued were the shares of Common Stock, if any, actually issued
upon the exercise of such Options or the conversion or exchange of such
Convertible Securities and the consideration received therefor was the
consideration actually received by the Company for the issue of all such
Options, whether or not exercised, plus the consideration actually received by
the Company upon such exercise, or for the issue of all such Convertible
Securities which were actually converted or exchanged, plus the additional
consideration, if any, actually received by the Company upon such conversion or
exchange, and

                                                      (B) in the case of Options
for Convertible Securities only the Convertible Securities, if any, actually
issued upon the exercise thereof were issued at the time of issue of such
Options, and the consideration received by the Company for the Additional Shares
of Common Stock deemed to have been then issued was the consideration actually
received by the Company for the issue of all such Options, whether or not
exercised, plus the consideration deemed to have been received by the Company
(determined pursuant to Section 2.3(e) hereof) upon the issue of the Convertible
Securities with respect to which such Options were actually exercised;

                                            (4) no readjustment pursuant to
clause (2) or (3) above shall have the effect of increasing the Applicable
Conversion Price to an amount which exceeds the lower of: (i) the Applicable
Conversion Price on the original date on which an adjustment was made pursuant
to this Section 2.3(c)(i), or (ii) the Applicable Conversion Price that would
have resulted from any issuance of Additional Shares of Common Stock between
such original adjustment date and the date on which a readjustment is made
pursuant to clause (2) or (3) above;

                                            (5) in the case of any Options which
expire by their terms not more than thirty (30) days after the date of issue
thereof, no adjustment of the Applicable Conversion Price shall be made until
the expiration or exercise of all such Options, whereupon such adjustment shall
be made in the same manner provided in clause (3) above; and


<PAGE>


                                            (6) if such record date shall have
been fixed and such Options or Convertible Securities are not issued on the date
fixed therefor, the adjustment previously made in the Applicable Conversion
Price that became effective on such record date shall be canceled as of the
close of business on such record date, and thereafter the Applicable Conversion
Price shall be adjusted pursuant to this Section 2.3(c) as of the actual date of
their issuance.

                                    (ii) STOCK DIVIDENDS, STOCK DISTRIBUTIONS
AND SUBDIVISIONS. In the event the Company at any time or from time to time
after the Original Issue Date shall declare or pay any dividend or make any
other distribution on the Common Stock payable in Common Stock, or effect a
subdivision of the outstanding shares of Common Stock (by reclassification or
otherwise than by payment of a dividend in Common Stock), then and in any such
event, Additional Shares of Common Stock shall be deemed to have been issued:

                                            (1) in the case of any such dividend
or distribution, immediately after the close of business on the record date for
the determination of holders of any class of securities entitled to receive such
dividend or distribution, or

                                            (2) in the case of any such
subdivision, at the close of business on the date immediately prior to the date
upon which such corporate action becomes effective.

                                            If such record date shall have been
fixed and such dividend shall not have been paid on the date fixed for the
payment thereof, the adjustment previously made in the Applicable Conversion
Price which became effective on such record date shall be canceled as of the
close of business on such record date, and thereafter the Applicable Conversion
Price shall be adjusted pursuant to this Section 2.3(c) as of the time of actual
payment of such dividend.

                           (d) ADJUSTMENT OF APPLICABLE CONVERSION PRICE OF
NOTES UPON ISSUANCE OF ADDITIONAL SHARES OF COMMON STOCK. In the event the
Company shall issue Additional Shares of Common Stock (including Additional
Shares of Common Stock deemed to be issued pursuant to Section 2.3(c)(i), but
excluding Additional Shares of Common Stock deemed to be issued pursuant to
Section 2.3(c)(ii), which event is dealt with in Section 2.2 hereof) without
consideration or for a consideration per share less than the Applicable
Conversion Price for this Note in effect on the date of and immediately prior to
such issue, then and in such event, such Applicable Conversion Price for this
Note shall be reduced concurrently with such issue, to a price (calculated to
the nearest cent) equal to the consideration per share for which such Additional
Shares of Common Stock are so issued.

                           (e) DETERMINATION OF CONSIDERATION. For purposes of
this Section 2.3, the consideration received by the Company for the issue of any
Additional Shares of Common Stock shall be computed as follows:

                                    (i) CASH AND PROPERTY: Such consideration
shall:


<PAGE>


                                            (1) insofar as it consists of cash,
be the aggregate amount of cash received by the Company excluding amounts paid
or payable for accrued interest or accrued dividends;

                                            (2) insofar as it consists of
property other than cash, be computed at the fair value thereof at the time of
such issue, as determined in good faith by the Board of Directors; and

                                            (3) in the event Additional Shares
of Common Stock are issued together with other shares of securities or other
assets of the Company for a single undivided consideration, be the proportion of
such consideration so received allocable to such Additional Shares of Common
Stock, computed as provided in clauses (1) and (2) above, as determined in good
faith by a Special Majority of the Board of Directors.

                                    (ii) OPTIONS AND CONVERTIBLE SECURITIES. The
consideration per share received by the Company for Additional Shares of Common
Stock deemed to have been issued pursuant to Section 2.3(c)(i) shall be
determined by dividing

                                            (x) the total amount, if any,
received or receivable by the Company as consideration for the issue of such
Options or Convertible Securities, plus the minimum aggregate amount of
additional consideration (as set forth in the instruments relating thereto,
without regard to any provision contained therein for a subsequent adjustment of
such consideration) payable to the Company upon the exercise of such Options or
the conversion or exchange of such Convertible Securities, or in the case of
Options for Convertible Securities, the exercise of such Options for Convertible
Securities and the conversion or exchange of such Convertible Securities, by

                                            (y) the maximum number of shares of
Common Stock (as set forth in the instruments relating thereto, without regard
to any provision contained therein for a subsequent adjustment of such number)
issuable upon the exercise of such Options or the conversion or exchange of such
Convertible Securities.

                           (f) ADJUSTMENT FOR STOCK DIVIDENDS, STOCK
DISTRIBUTIONS, SUBDIVISIONS, COMBINATIONS OR CONSOLIDATIONS OF COMMON STOCK.

                                    (i) STOCK DIVIDENDS, STOCK DISTRIBUTIONS OR
SUBDIVISIONS. In the event the Company shall issue Additional Shares of Common
Stock pursuant to Section 2.3(c)(ii) in a stock dividend, other stock
distribution or subdivision, the Applicable Conversion Price in effect
immediately prior to such stock dividend, stock distribution or subdivision
shall, concurrently with the effectiveness of such stock dividend, stock
distribution or subdivision, be proportionately decreased to adjust equitably
for such dividend, distribution or subdivision.

                                    (ii) COMBINATIONS OR CONSOLIDATIONS. In the
event the outstanding shares of Common Stock shall be combined or consolidated,
by reclassification or otherwise, into a lesser number of shares of Common
Stock, the Applicable Conversion Price in effect immediately prior to such
combination or consolidation shall, concurrently with the effectiveness


<PAGE>


of such combination or consolidation, be proportionately increased to adjust
equitably for such combination or consolidation.

                           (g) CERTIFICATE AS TO ADJUSTMENTS. Upon the
occurrence of each adjustment or readjustment of the Applicable Conversion Price
pursuant to this Section 2.3, the Company at its expense shall promptly compute
such adjustment or readjustment in accordance with the terms hereof and furnish
to the Holder a certificate setting forth such adjustment or readjustment and
showing in detail the facts upon which such adjustment or readjustment is based.
The Company shall, upon the written request at any time of the Holder, furnish
or cause to be furnished to such Holder a like certificate setting forth (i) all
such adjustments and readjustments theretofore made, (ii) the Applicable
Conversion Price at the time in effect, and (iii) the number of shares of Common
Stock and the amount, if any, of other property which at such time would be
received upon the conversion of this Note.

                  2.4. MANDATORY CONVERSION. At any time after a Designated
Offering, the outstanding principal of this Note shall be converted to Common
Stock at the Company's election in the event the sum of (a) the average closing
bid price for the Common Stock over twenty (20) consecutive trading days, plus
(b) all accrued interest on this Note (when converted to an amount per share
using the Conversion Price then in effect), equals or exceeds $13.72 per share.

                  2.5.     METHOD OF CONVERSION.

                           (a) FULL CONVERSION. Except as otherwise provided in
Section (b) below, this Note may be converted by the Holder in whole, but not in
part, by the surrender of this Note at the principal office of the Borrower,
accompanied by a written request from the Holder for conversion of the Note as
provided in Section 2.1 or 2.2 hereof at the then Applicable Conversion Price.
Upon the surrender of this Note, accompanied by the Holder's written request for
conversion, Borrower shall issue and deliver to the Holder that number of shares
of Common Stock for the Note converted. The number of shares of Common Stock to
be issued upon conversion of this Note shall be determined by dividing the
principal of the Note to be converted by the Conversion Price.

                           (b) CONVERSION PURSUANT TO SECTION 2.2(e). In
connection with the exercise of any Holder of its rights under the Co-Sale
provision set forth in Section 2 of the Investors Rights Agreement, this Note
may be converted by the Holder in whole or in part, pursuant to Section 2.2(e)
hereof, by the surrender of this Note at the principal office of the Borrower,
accompanied by a written request from the Holder for conversion of such part of
the Note to acquire the number of Shares to be sold by a Holder pursuant to the
exercise of such Co-Sale rights. Upon such partial exercise hereof, a new Note
containing the same date and provisions of this Note shall be issued by the
Borrower to the Holder for the principal balance of this Note which shall not
have been converted.

                  2.6. NO IMPAIRMENT. The Company will not, by amendment of its
Certificate of Incorporation or through any reorganization, transfer of assets,
consolidation, merger, dissolution, issue or sale of securities or any other
voluntary action, avoid or seek to avoid the observance or performance of any of
the terms to be observed or performed hereunder by the


<PAGE>


Company but will at all times in good faith assist in the carrying out of all
the provisions of this Section 2 and in the taking of all such action as may be
necessary or appropriate in order to protect the Conversion Rights of the
holders of the Notes against impairment. Without limiting the generality of the
foregoing, before taking any action which would result in any adjustment to the
Applicable Conversion Price then in effect below the par value of the Common
Stock, the Company will take or cause to be taken any and all necessary
corporate or other action which may be necessary in order that the Company may
validly and legally issue fully paid and nonassessable shares of such Common
Stock upon receipt of such Applicable Conversion Price as so adjusted. The
taking of such corporate or other action shall be a condition precedent to the
Company's taking the action which would result in such adjustment.

                  2.7. COMMON STOCK RESERVED. The Company shall reserve and at
all times keep available out of its authorized but unissued Common Stock, free
from preemptive or other preferential rights, restrictions, reservations,
dedications, allocations, options, other warrants and other rights under any
stock option, conversion option or similar agreement, such number of shares of
Common Stock as shall from time to time be sufficient to effect conversion of
the Notes.

                                   ARTICLE III

                              REPAYMENT AT MATURITY

                  3.1. PAYMENT. In the event the Holder has not converted to
Common Shares prior to the Maturity Date, Borrower shall pay in United States
currency to the Holder the outstanding principal amount hereof, all accrued and
unpaid interest hereon, the Maturity Date Premium and any and all other amounts
due and payable hereunder in immediately available federal funds on the Maturity
Date.

                  3.2. NOTICE OF INTENTION. Not more than 150 days prior to the
Maturity Date nor less than 120 days prior to the Maturity Date, Borrower shall
deliver to Holder, a Request for Notice of Intention substantially in the form
of EXHIBIT I hereto. In the event Holder does not deliver a reply to Borrower at
least 90 days prior to the Maturity Date, Borrower may by written notice to the
Holder at least 30 days prior to the maturity elect not to pay Holder all
amounts due hereunder as required in Section 3.1 hereof on the Maturity Date;
whereupon the Maturity Date and Borrower's obligation to make payment hereunder
shall be extended for a period ending on the 120th day after a demand for
payment is delivered by the Holder to the Borrower during which extension period
all of the terms and conditions, covenants and other obligations of the Borrower
hereunder and under the Documents shall remain in full force and effect.

                                   ARTICLE IV

                                EVENTS OF DEFAULT

                  The occurrence of any of the following events of default (each
a "Event of Default") shall, at the option of the Holder hereof on written
notice to the Borrower, make all


<PAGE>


sums of principal and interest then remaining unpaid hereon, and all other
amounts payable hereunder immediately due and payable, all without demand,
presentment or notice, or grace period, all of which hereby are expressly
waived; PROVIDED, HOWEVER, that in the case of an event described in Section 4.5
hereof the obligations of the Company under this Note shall immediately become
due and payable without any election or action on the part of the Holder:

                  4.1. FAILURE TO PAY PRINCIPAL OR INTEREST. The Borrower fails
to pay any principal of or interest on the Note or any other fee when due and
payable;

                  4.2. BREACH OF COVENANT. The Borrower breaches any covenant or
other term or condition of this Note and/or the Documents and such breach
continues unremedied for a period of ten (10) days from the date of delivery of
a notice from a Holder of a Note;

                  4.3. BREACH OF REPRESENTATIONS AND WARRANTIES. Any
representation or warranty of the Borrower made herein, in the Documents, or in
any agreement, statement or certificate given in writing pursuant hereto or in
connection herewith or therewith shall be false or misleading in any material
respect;

                  4.4. OTHER INDEBTEDNESS. The Borrower shall (a) fail to pay
(within the applicable cure period, if any) any indebtedness for borrowed money
(other than the Notes) of the Borrower or any interest or premium thereon, when
due (whether by scheduled maturity, required prepayment, acceleration, demand,
or otherwise); or (b) fail to perform or observe any term, covenant, or
condition on its part to be performed or observed (within the applicable cure
period, if any) under any agreement or instrument relating to any such
indebtedness, when required to be performed or observed, if the effect of such
failure to perform or observe is to accelerate, or permit the acceleration of
after the giving of notice or passage of time, or both, the maturity of such
indebtedness, whether or not such failure to perform or observe shall be waived
by the holder of such indebtedness, or any such indebtedness shall be declared
to be due and payable, or required to be prepaid (other than by a regularly
scheduled required prepayment), prior to the stated maturity thereof;

                  4.5. INABILITY TO PAY DEBTS. The Borrower (a) shall generally
not pay, or shall be unable to pay, or shall admit in writing its inability to
pay its debts as such debts become due; or (b) shall make an assignment for the
benefit of creditors, or petition or apply to any tribunal for the appointment
of a custodian, receiver, or trustee for it or a substantial part of its assets;
or (c) shall commence any proceeding under any bankruptcy, reorganization,
arrangement, readjustment of debt, dissolution, or liquidation law or statute of
any jurisdiction, whether now or hereafter in effect; or (d) shall have had any
such petition or application filed or any such proceeding commenced against it
in which an order for relief is entered or an adjudication or appointment is
made and which remains undismissed for a period of 30 days or more; or (e) shall
take any corporate action indicating its consent to, approval of, or
acquiescence in any such petition, application, proceeding, or order for relief
or the appointment of a custodian, receiver, or trustee for all or any
substantial part of its properties; or (f) shall suffer any such custodianship,
receivership, or trusteeship to continue undischarged for a period of 30 days or
more; or


<PAGE>


                  4.6 FAILURE TO REGISTER SHARES. The Borrower shall fail to
register the Shares into which the Notes may be converted at the time of any
public offering of the Common Stock of the Borrower (including but not limited
to a Designated Offering) pursuant to the terms of the Subscription Agreement.

                                    ARTICLE V

                                  MISCELLANEOUS

                  5.1. FAILURE OR INDULGENCY NOT WAIVER. No failure or delay on
the part of Holder hereof in the exercise of any power, right or privilege
hereunder shall operate as a waiver thereof, nor shall any single or partial
exercise of any such power, right or privilege preclude other or further
exercise thereof or of any other right, power or privilege. All rights and
remedies existing hereunder are cumulative to, and not exclusive of, any rights
or remedies otherwise available.

                  5.2. NOTICES. Any notice, request, consent, or other
communication herein required or permitted to be given shall be in writing and
may be personally served and shall be deemed to be delivered upon receipt or
sent by United States mail and shall be deemed to have been given three (3) days
after being deposited in the United States mail, certified, registered, with
postage pre-paid and properly addressed or on receipt, or sent by fax
transmission (with the original sent by certified or registered mail or by
overnight courier) and shall be deemed to have been delivered on the day
telecopied. For the purposes hereof, the address and fax number of the Holder is
as set forth on the first page hereof the address and fax number of the Borrower
is as set forth on the signature page hereof. Both Holder and Borrower may
change the address and fax number for service by service of written or fax
notice to the other as herein provided. Notice of Conversion shall be deemed
given when made pursuant to the Subscription Agreement. All such notices,
requests, consents and other communications shall be deemed to have been
delivered (a) in the case of personal delivery or delivery by telecopy, on the
date of such delivery, provided such day is a business day; otherwise on the
next business day following such delivery, (b) in the case of dispatch by
nationally-recognized overnight courier, on the next business day following such
dispatch and (c) in the case of mailing, on the third business day after the
posting thereof.

                  5.3. AMENDMENT PROVISION. The term "Note" and all reference
thereto, as used throughout this instrument, shall mean this instrument as
originally executed, or if later amended or supplemented, then as so amended or
supplemented.

                  5.4. ASSIGNABILITY. This Note shall be binding upon the
Borrower and its successors and assigns, and shall inure to the benefit of the
Holder and its successors and assigns.

                  5.5. COST OF COLLECTION. If default is made in the payment of
this Note, Borrower shall pay the Holder hereof costs of collection, including
attorneys' fees and expenses.

                  5.6. CHOICE OF LAW. It is the intention of the parties that
the laws of New York shall govern the validity of this Agreement, the
construction of its terms and the interpretation of the rights and duties of the
parties.


<PAGE>


                  5.7. SUBMISSION TO JURISDICTION; CONSENT TO SERVICE OF
PROCESS. The Company hereby submits to the non-exclusive jurisdiction of the
United States District Court for the Southern District of New York and of any
New York State court sitting in The City of New York for purposes of all legal
proceedings which may arise hereunder. The Company irrevocably waives to the
fullest extent permitted by law, any objection which it may have or hereafter
have to the laying of the venue of any such proceeding brought in such a court,
any claim that any such proceeding brought in such a court has been brought in
an inconvenient forum and trial by jury. The Company hereby consents to process
being served in any such proceeding by the mailing of a copy thereof by
registered or certified mail, postage prepaid, to its address specified in
Section 5.2 hereof or in any other manner permitted by law.

                  5.8. WAIVER OF TRIAL BY JURY. THE COMPANY HEREBY WAIVES TRIAL
BY JURY IN ANY ACTION, PROCEEDING, CLAIM OR COUNTERCLAIM, WHETHER IN CONTRACT OR
TORT, AT LAW OR IN EQUITY, ARISING OUT OF OR IN ANY WAY RELATED TO THIS NOTE.


<PAGE>


                  IN WITNESS WHEREOF, Borrower has caused this Note to be signed
in its name by its President on this ____ day of March, 1999.

                                     TRANSGENOMIC, INC.

                                     By:________________________________
                                     Name:________________________________
                                     Title:________________________________

                                     ADDRESS FOR NOTICES:

                                     5600 South 42nd Street
                                     Omaha, Nebraska 68107
                                     Telecopy:   (402) 733-1264


<PAGE>


                                                   EXHIBIT I TO CONVERTIBLE NOTE

                         REQUEST FOR NOTICE OF INTENTION

[Name]
[Address]

                           Re:  Convertible Note # CN-000 ___

Dear Sirs:

         The Maturity Date of the above referenced Note is March ____, 2002. We
hereby request you notify us of your Intention with respect to conversion of the
Note into Common Stock pursuant to Article II of the Note or repayment of the
Note by checking the appropriate box below, countersign this letter in the space
provided and returning this letter to us.

                                            Very truly yours,

                                            Transgenomic, Inc.

                                            By: _________________________
                                            Name:_________________________
                                            Title:_________________________

The undersigned, an authorized representative of _________________________, the
holder of Convertible Note # CN-000 ____, hereby notifies you that the Holder
elects to:

         _   Convert the Note pursuant to Article II of the Note.

         _   Receive payment in full on the Maturity Date.

Note Holder: ____________________________
                  [print name]

By: _____________________________
Name:_____________________________
Title:_____________________________

<PAGE>

                                                                    EXHIBIT 10.6

                               TRANSGENOMIC, INC.
                              AMENDED AND RESTATED
                             1997 STOCK OPTION PLAN

                                    ARTICLE I

                                NAME AND PURPOSES

         Section 1.1. NAME. The name of the plan shall be the Transgenomic, Inc.
1997 Stock Option Plan (the "Plan"). The Plan was originally adopted as of the
Effective Date set forth in Section 11.3 hereof and is hereby amended and
restated as provided herein as of the 1st day of December, 1997.

         Section 1.2. PURPOSE. The purpose of the Plan is to enable the
Employees, directors and Advisors of Transgenomic, Inc. (the "Company") to share
in the growth and prosperity of the Company by encouraging stock ownership by
Employees, directors and Advisors and to assist the Company to obtain and retain
key management personnel. Either Incentive Stock Options or Nonqualified Stock
Options may be granted to Employees of the Company under the Plan but only
Nonqualified Stock Options may be granted to Non-Employee Directors and Advisors
under the Plan.

                                   ARTICLE II

                                   DEFINITIONS

         "ADVISOR" means a person who is not an employee of the Company but who
has agreed to serve as a source of information and advice regarding scientific,
technical or other matters relating to the Company's business and products.

          "BOARD" means the Board of Directors of the Company.

         "CAUSE" means conduct involving fraud, gross negligence, breach of a
fiduciary duty or criminal activity.

         "CHANGE OF CONTROL" means the approval by the Company's shareholders of
(a) a merger or consolidation of the Company with or into another corporation
(other than a merger or consolidation in which the Company is the surviving
corporation and which does not result in any capital reorganization or
reclassification or other change in the Company's then outstanding shares of
common stock); (b) a sale or disposition of all or substantially all of the
Company's assets; or (c) a plan of liquidation or dissolution of the Company.

         "CODE" means the Internal Revenue Code of 1986, as amended.

         "COMMITTEE" means the Compensation Committee of the Board. If the Board
does not have a Compensation Committee, the Board shall constitute the
Compensation Committee.

         "COMPANY" means Transgenomic, Inc., a Delaware corporation, and its
successors.


<PAGE>


         "COMPANY STOCK" means shares of the common stock, par value $.01 per
share, of the Company.

         "EMPLOYEE" means any person employed by the Company as an employee and
not as an independent contractor.

         "EXCHANGE ACT" means the Securities and Exchange Act of 1934, as
amended.

         "FAIR MARKET VALUE" means the fair market value of the Company Stock as
of the relevant time under this Agreement. If the Company Stock is not publicly
traded, Fair Market Value shall be reasonably determined by the Committee. If
the Company Stock is publicly traded, then the Fair Market Value will be equal
to the average of the closing sales price per share for the five trading days
immediately preceding the date of the determination.

         "INCENTIVE STOCK OPTION" means any stock option granted to an Employee
under the Plan, which the Committee intends at the time it is granted to be an
incentive stock option within the meaning of Section 422 of the Code.

         "NON-EMPLOYEE DIRECTOR" means any person who is a member of the Board
but is not an Employee of the Company and has not been an Employee of the
Company or any subsidiary of the Company at any time during the preceding 12
months. Service as a director does not in itself constitute employment for
purposes of this definition.

         "NONQUALIFIED STOCK OPTION" means any stock option granted to an
Employee, Non-Employee Director or Advisor under the Plan which is not a stock
option within the meaning of Section 422 of the Code.

         "OPTIONEE" is any Employee, Non-Employee Director or Advisor who has
been granted Options under the Plan.

         "OPTIONS" mean Nonqualified Stock Options and Incentive Stock Options.

         "PARTICIPANT" means any Employee, Non-Employee Director or Advisor who
meets the requirements for participation in the Plan as described in Article
III.

         "PERMANENT AND TOTAL DISABILITY" means, as determined by the Committee,
an illness or injury of a potentially permanent nature, expected to last for a
continuous period of at least 12 months, certified by a physician selected by or
satisfactory to the Committee, which prevents the Participant from engaging in
any occupation for wage or profit for which the Participant is reasonably fitted
by training, education or experience.

         "QUALIFYING STOCK" means Company Stock which has been owned by an
Employee for at least six months prior to the date of exercise of an Option and
has not been used in a stock-for-stock swap transaction within the preceding six
months.


                                       2
<PAGE>


                                   ARTICLE III

                          ELIGIBILITY AND PARTICIPATION

         Every Employee, Non-Employee Director and Advisor shall be eligible to
become a Participant in the Plan. Only Employees shall be eligible for the
Incentive Stock Options, and Employees, Non-Employee Directors and Advisors
shall be eligible for the Nonqualified Stock Options. The Committee shall
determine the number and type of Options granted and Participants to receive
awards under the Plan.

                                   ARTICLE IV

                                OPTION CONDITIONS

         Section 4.1. NO OPTION COMBINATIONS. Options under the Plan may only be
granted as either Incentive Stock Options or as Nonqualified Stock Options
dependent upon whether the Participant is an Employee, a Non-Employee Director
or an Advisor. Incentive Stock Options may only be granted to Employees, and
Nonqualified Stock Options may be granted to Employees, Non-Employee Directors
or Advisors.

         Section 4.2. OPTION CONDITIONS. Without limiting the Committee's
authority, the Committee may make the grant of Options conditional upon an
election by a Participant to defer payment of a portion of his or her
compensation and subject to any condition or conditions consistent with the
terms of the Plan that the Committee in its sole discretion may determine.

         Section 4.3. COMMITTEE MEMBERS. Voting members of the Committee shall
neither receive any Option pursuant to the Plan while serving on the Committee
unless such an Option is a formula award within the meaning of Rule 16b-3 under
the Exchange Act nor have received any such Option or any other grant or award
of equity securities pursuant to the Plan or any other plan of the Company or
any of its affiliates or subsidiaries at any time within one year prior to his
or her service on the Committee or, if different, for the time period necessary
to fulfill the then current requirements of Rule 16b-3 under the Exchange Act.
However, provided that, if for any reason the Committee does not qualify to
administer the Plan, as contemplated by Rule 16b-3 of the Exchange Act, then the
Board may appoint a new Committee so as to comply with Rule 16b-3.

         Section 4.4. EFFECTIVE DATE OF PRIOR SECTION. Section 4.3 hereof shall
take effect on the day following the date on which a registration statement
filed by the Company with the Securities and Exchange Commission is first
declared effective under the Securities Act of 1933, as amended.


                                       3
<PAGE>


                                    ARTICLE V

                          COMPANY STOCK SUBJECT TO PLAN

         The total number of Company Stock for which Options may be granted
under the Plan shall not exceed 4,000,000 shares of Company Stock subject always
to the provisions of Article VIII. The Company Stock issued under the Plan may
be authorized and unissued shares or treasury shares.

         In the event that any outstanding Option issued pursuant to the Plan
shall expire or terminate, additional Options for the number of shares of
Company Stock which were subject to such expired or terminated Options may be
granted under the Plan. In addition, if shares of Company Stock are used by an
Optionee to pay all or a part of the exercise price of any Option (or applicable
withholding taxes), additional Options for the number of shares of Company Stock
so used may be granted under the Plan, including Replacement Options granted
under Section 6.3 hereof.

                                   ARTICLE VI

                                     OPTIONS

         Section 6.1. TERMS OF OPTIONS. (a) The Committee from time to time may
grant Options. Each Option granted shall be embodied in a written agreement
between the Company and the Participant in such form and containing such
provisions as the Committee from time to time shall deem appropriate, consistent
with the requirements of the Plan and this Amendment. Option agreements need not
be identical, and the Option agreement shall specify whether or not an Option is
an Incentive Stock Option.

         (b) The exercise price for each Option granted under the Plan shall be
fixed by the Committee in good faith, but in no event shall the exercise price
of any Incentive Stock Option be less than 100% of the Fair Market Value of the
Company Stock on the date such Incentive Stock Option is granted.

         (c) The Committee shall fix the term or duration of all Options issued
under this Plan, provided that such term shall not exceed ten years after the
date on which the Option was granted.

         (d) At all times during the period beginning on the date of the grant
of an Incentive Stock Option and ending on the day three months before the date
of the exercise of such Incentive Stock Option, the Optionee must be an Employee
of the Company. Options designated as Incentive Stock Options that fail to meet
the requirements of Section 422 of the Code shall be redesignated as
Nonqualified Stock Options for federal income tax purposes automatically without
further action by the Committee on the date of such failure to continue to meet
the requirements of Section 422 of the Code.


                                       4
<PAGE>


         Section 6.2. TRANSFERABILITY OF OPTIONS. Options shall not be
transferable otherwise than by will or the laws of descent and distribution or
pursuant to a qualified domestic relations order, as defined in the Code, and
during the Participant's lifetime such Options shall be exercisable only by the
Participant.

         Section 6.3. REPLACEMENT OPTION. The Committee may grant a replacement
option (a "Replacement Option") to any Employee who exercises all or part of an
Option granted under this Plan using Qualifying Stock as payment for the
exercise price. A Replacement Option shall grant to the Employee the right to
purchase, at a price not less than the Fair Market Value of the Company Stock as
of the date of said grant, the number of shares of stock equal to the sum of the
number of whole shares (i) used by the Employee in payment of the exercise price
for the Option which was exercised and (ii) used by the Employee in connection
with applicable withholding taxes on such transaction. A Replacement Option may
not be exercised for six months following the date of grant, and shall expire on
the same date as the Option which it replaces.

                                   ARTICLE VII

                                 ADMINISTRATION

         Section 7.1. AUTHORITY OF THE COMMITTEE. (a) The Plan shall be
administered by the Committee. A majority vote of the Committee at which a
quorum is present, or acts reduced to or approved in writing by a majority of
the members of the Committee, shall be the valid acts of the Committee for the
purposes of this Plan.

         (b) The Committee shall have plenary authority in its discretion, but
subject to the express provisions of the Plan, to determine the terms of all
Options granted under the Plan, including, without limitation, the purchase
price, if any, the Participants to whom and the time or times at which Options
shall be granted, when an Option can be exercised and whether in whole or in
installments, and the number of shares covered by an Option and to interpret the
Plan and to make all other determinations deemed advisable for the
administration of the Plan. All determinations of the Committee shall be made by
not less than a majority of its members. The Committee may designate Employees
of the Company to assist the Committee in the administration of the Plan and may
grant authority to such persons to execute Option agreements or other documents
on behalf of the Committee.

         (c) The Committee may make such rules and regulations and establish
such procedures as it deems appropriate for the administration of the Plan.

         (d) In the event of a disagreement as to the interpretation of the Plan
or any amendment hereto or any rule, regulation or procedure thereunder or as to
any right or obligation arising from or related to the Plan, the decision of the
Committee shall be final and binding. No member of the Committee shall be liable
for any action or determination made in good faith with respect to the Plan or
any benefit granted under it.

         Section 7.2. PAYMENT FOR OPTIONS. Payment in full for the number of
shares purchased under any Option shall be made to the Company at the time of
such exercise. The Committee, in its discretion, may provide that any Option by
its terms may permit a Participant to elect, subject to Committee approval, to
pay for an exercised Option in any combination of cash and Company


                                       5
<PAGE>


Stock. Shares of Company Stock used to pay all or a part of the exercise price
of an Option will be valued at their Fair Market Value on the date of the
exercise of the Option.

                                  ARTICLE VIII

                        ADJUSTMENT UPON CHANGES OF STOCK

         If any change is made with respect to the Company Stock by reason of
any stock dividend, stock split or combination of shares, appropriate
adjustments shall be made by the Committee to the maximum number of shares
subject to the Plan and the number of shares and price per share of Company
Stock subject to each outstanding Option. No fractional shares of Company Stock
resulting from any such adjustment shall be issued upon exercise of an Option,
but the Fair Market Value of any such fractional share shall be paid in cash
upon such exercise.

                                   ARTICLE IX

                           EFFECT OF CORPORATE CHANGES

         An Optionee shall not have any additional right to exercise any
outstanding Options, whether or not vested, in whole or in part, solely by
reason of any Change of Control, merger, consolidation, reorganization,
recapitalization, exchange of shares, or change in corporate structure
(including an initial public offering), than such Optionee had prior to such an
event. If a Change of Control, merger, consolidation, reorganization,
recapitalization, exchange of shares, or change in corporate structure
(including an initial public offering) shall occur, the Committee may, but shall
not be required to, accelerate or adjust the vesting of Options, solely at the
discretion of the Committee and subject to the terms of the Plan.

                                    ARTICLE X

                             TERMINATION OF OPTIONS

         Section 10.1. DEATH OF OPTIONEE. (a) If the Optionee shall die at any
time after the date an Option is granted and prior to any termination thereof,
the executor or administrator of the estate of the Optionee or the person or
persons to whom the Option shall have been validly transferred by the executor
or the administrator pursuant to will or the laws of descent and distribution
shall have the right, during the period ending one year after the date of the
Optionee's death, to exercise the Option to the extent that it was exercisable
at the date of death and shall not have been exercised. Any Options not
exercised within said time period shall terminate and all rights thereunder
shall cease. In the event of the Optionee's death, any Options not vested as of
the date of the Optionee's death shall become immediately vested; provided,
however, that the Optionee was continuously employed by the Company, or
continuously served on the Board or as an Advisor, for at least three years, or
such shorter period as the Committee determines in its sole discretion.

         (b) Notwithstanding the foregoing, no transfer of an Option by will or
the laws of descent and distribution shall be effective to bind the Company
unless the Company shall have been furnished with written notice thereof and an
authenticated copy of the will and/or such


                                       6
<PAGE>


other evidence as the Committee may deem necessary to establish the validity of
the transfer and the acceptance by the transferee or transferees of the terms
and conditions of the Option.

         Section 10.2. PERMANENT AND TOTAL DISABILITY. If the Optionee becomes
Permanently and Totally Disabled at any time after the date an Option is granted
and prior to any termination thereof, the Optionee (or in the case of the
Optionee becoming mentally incapacitated, his guardian or legal representative)
shall have the right, during a period ending one year after such Permanent and
Total Disability, to exercise the Option to the extent that it was exercisable
at the date of such Permanent and Total Disability and shall not have been
exercised. Any Options not exercised within said time period shall terminate and
all rights thereunder shall cease. In the event of the Optionee's Permanent and
Total Disability, any Options not vested as of the date of the Optionee's
Permanent and Total Disability shall become immediately vested; provided,
however, that the Optionee was continuously employed by the Company, or
continuously served on the Board or as an Advisor, for at least three years, or
such shorter period as the Committee determines in its sole discretion.

         Section 10.3. OTHER. (a) In the event of an Optionee's termination of
employment with the Company or from the Board or as an Advisor, or in the event
an Optionee's employment is terminated for any reason other than death or
Permanent and Total Disability, any Options not vested as of the date of the
Optionee's resignation or termination shall immediately terminate and all rights
thereunder shall cease unless the Committee determines otherwise in its sole
discretion.

         (b) If the Optionee's employment or directorship with the Company or
service as an Advisor is terminated by the Company for Cause, the Optionee's
right to exercise an Option, whether or not vested, shall immediately terminate
and all rights thereunder shall cease unless the Committee determines otherwise
in its sole discretion.

                                   ARTICLE XI

                                  MISCELLANEOUS

         Section 11.1. RIGHTS OF EMPLOYEES AND NON-EMPLOYEE DIRECTORS. Neither
this Plan nor any Option granted hereunder shall confer upon any Employee or
Non-Employee Director any right to continue to serve as an employee or director
of the Company.

         Section 11.2. WITHHOLDING. The Company shall have the right to withhold
with respect to any payments made to Participants under the Plan any taxes
required by law to be withheld because of such payments. With respect to any
such withholding:

                  (a) Each Participant shall take whatever action that the
         Committee deems appropriate to comply with the law regarding
         withholding of federal, state and local taxes.

                  (b) When a Participant is obligated to pay to the Company an
         amount required to be withheld under applicable income tax laws in
         connection with an Option, the Committee may, in its discretion and
         subject to such rules as it may adopt, permit the Participant to
         satisfy this obligation, in whole or in part, either (i) by having the
         Company


                                       7
<PAGE>


         withhold from the shares to be issued upon the exercise of an Option or
         (ii) by delivering to the Company already-owned shares to satisfy the
         withholding amount.

         Section 11.3. EFFECTIVE DATE. This Plan is effective on June 27, 1997
("Effective Date"). Options hereunder may be granted at any time subject to the
limitations contained within the Plan. No Company Stock may be issued unless the
Plan is approved by a vote of the holders of a majority, or as otherwise
provided in the Company's First Amended and Restated Articles of Incorporation,
of the outstanding shares of the Company's common stock at a meeting of the
stockholders of the Company held within 12 months following the Effective Date.

                                   ARTICLE XII

                                  MISCELLANEOUS

         Section 12.1. AMENDMENT. The Board may amend the Plan from time to time
as it deems desirable or as necessitated by any applicable rules and regulations
and such amendments shall include the ability of the Board to amend the Plan
and, with shareholder approval, to increase the number of shares subject to the
Plan; provided, however, the Plan may not be amended to decrease the price at
which Incentive Stock Options may be granted. Any amendment to the Plan shall
not apply to (i) Options granted to Non-Employee Directors prior to the
effective date of the amendment or (ii) Options granted to Employees or Advisors
that have vested prior to the effective date of the amendment unless, in either
case, it has been otherwise agreed to, in writing, by the Committee and the
affected Plan Participant.

         Section 12.2. TERMINATION OF PLAN. The Board may, in its discretion,
terminate the Plan at any time, but no such termination shall deprive
Participants of their rights under outstanding Options.

         Section 12.3. GOVERNING LAW. This Plan shall be construed in accordance
with and governed by the laws of the State of Delaware.

                                       8


<PAGE>

                                                                    EXHIBIT 10.7

PRIVATE & CONFIDENTIAL





                           THE TRANSGENOMIC INC. 1997
                                STOCK OPTION PLAN

                            (AS AMENDED AND RESTATED)

                     UK APPROVED STOCK OPTION SUB PLAN 1999

                APPROVED BY THE INLAND REVENUE UNDER REF: X19932










                                DELOITTE & TOUCHE
                                   HILL HOUSE
                              1, LITTLE NEW STREET
                                     LONDON
                                    EC4A 3TR

                                  Ref:- SVW/NN


<PAGE>


                              THE TRANSGENOMIC INC.
                             1997 STOCK OPTION PLAN

                     UK APPROVED STOCK OPTION SUB PLAN 1999

1.   INTRODUCTION

1.1  For the purpose of granting options under a scheme approved by the United
     Kingdom's Inland Revenue under Schedule 9 to the United Kingdom's Income
     and Corporation Taxes Act 1988 ("Schedule 9"), the terms of the
     Transgenomic Inc. Amended and Restated 1997 Stock Option Plan, as amended
     and restated as of 14 October 1997 (hereafter called the "1997 Plan") are
     amended by the creation of the UK Share Option Sub-Plan 1999 ("the
     Sub-Plan") which shall be applicable to the employees of Transgenomic Inc.
     and its subsidiaries and affiliates who are resident in the United Kingdom.

1.2  The terms of the Sub Plan shall be the terms of the 1997 Plan, amended as
     set out below.

2.   NATURE OF OPTIONS

2.1  No options or rights may be granted under the Sub Plan other than Approved
     Stock Options.

2.2  The Company Stock over which Approved Stock Options are granted under the
     Sub Plan must satisfy paragraphs 10-14 of Schedule 9.

3.   ELIGIBILITY AND GRANT OF OPTIONS

3.1  No Approved Stock Options may be granted under the Sub Plan to a person who
     is not an employee or a full-time director of the Company or such companies
     under the control of the Company as may be nominated from time to time
     within the meaning of paragraph 27 of Schedule 9.

3.2  For the purposes of Rule 3.1 of this Sub Plan above, a person shall be
     treated as a full-time director of a Company if he is obliged to devote to
     the performance of the duties of his office of employment with the Company,
     or with the Company and any other participating Company, not less than 25
     hours a week (excluding meal-breaks).

3.3  No Approved Stock Options may be granted under the Sub Plan to, or
     exercised by, a person who is not eligible to participate by virtue of
     paragraph 8 of Schedule 9.

3.4. No person shall be granted an option under the Sub Plan for which the
     exercise price, when added to the exercise price of all Approved Stock
     Options for such individual subsisting under the Sub Plan, or any other
     option granted under a discretionary share option scheme approved by the
     United Kingdom Inland Revenue and established by the Company or any
     associated company (as defined in section 187(2) of the Income and
     Corporation Taxes Act 1988), would exceed L30,000 (or such limit as may
     from time to time be provided for by paragraph 28 of Schedule 9).


<PAGE>


3.5  No option shall be granted under this Sub Plan at any price which is less
     than its Fair Market Value, or in the case of an option to subscribe for
     shares, the nominal value of the Company Stock, if higher.

3.6  If and so long as the Company Stock is listed on the London Stock Exchange
     or the New York Stock Exchange, "Fair Market Value" shall mean its middle
     market quotation (as derived from the Daily Official List). If and so long
     as the Company Stock is not so listed, "Fair Market Value" shall mean the
     fair market value of the relevant stock on the relevant date, as determined
     in accordance with Part VIII of the Taxation of Chargeable Gains Act 1992
     and agreed in advance of each grant with the Shares Valuation Division of
     the UK Inland Revenue.

3.7  The Committee may grant an Approved Stock Option subject to such objective
     conditions as it may determine and specify at the date of grant, provided
     that such conditions have been approved by the UK Inland Revenue.

3.8  Section 6.3 of the 1997 Plan shall not apply.

3.9  Section 7.2 of the 1997 Plan shall read as if it contained only the words:

     "Payment in full for the number of shares purchased under any Approved
     Stock Option shall be made to the Company in cash at the time of such
     exercise".

3.10 The Committee shall procure the issue or transfer of shares pursuant to the
     exercise of an Approved Stock Option within 28 days following the effective
     date of exercise of the Option. Shares to be issued pursuant to the Sub
     Plan shall rank pari passu in all respects with the Company Stock of the
     same class for the time being in issue same as regards any rights attaching
     to a record date prior to the date of issue and in the case of a transfer
     of shares, the transferee shall not acquire any rights attaching to such
     shares by reference to a record date prior to the date of transfer.

4.   ADJUSTMENTS

4.1  Article VIII of the 1997 Plan shall read as if it contained only the words:

     "The number of shares of Company Stock over which an Approved Stock Option
     is granted and the exercise price shall be adjusted in such manner as the
     Committee shall determine following any capitalisation issue, rights issue,
     subdivision, consolidation or reduction of share capital of the Company or
     any other variation of share capital to the intent that (as nearly as may
     be without involving fractions of a share or an exercise price calculated
     to more than two places of decimals) the exercise price payable in respect
     of an Approved Stock Option shall remain unchanged provided that:-

     (a) the aggregate amount payable on the exercise of the Approved Stock
         Option in full is not increased;

     (b) the exercise price for shares of Company Stock is not reduced below its
         nominal value; and


<PAGE>


     (c) no such adjustment is made without the prior approval of the UK Inland
         Revenue.

5.   EFFECT OF CORPORATE CHANGES

5.1  If any person obtains Control (as defined in Rule 5.6 below) of the Company
     as a result of making:

     (a) a general offer to acquire the whole of the issued stock of the Company
        (where such an offer is made upon a condition such that if it is
         satisfied the person making the offer will have control of the
         Company; or

     (b) a general offer to acquire all the shares in the Company which are of
         the same class as the Company Stock subject to Approved Stock Options;

     any existing Approved Stock Option may be exercised within 6 months of the
     time when the person making such an offer obtains Control of the Company.

5.2  If, as a result of the events specified in 5.1 another Company has obtained
     Control of the Company, a holder of an Approved Stock Option may, by
     agreement with that other Company (the "Acquiring Company"), within 6
     months release such existing options held over the Company Stock (the "Old
     Option") for an option fulfilling the requirements of Rule 5.3 (a "New
     Option").

5.3  An Approved Stock Option shall only be New Option if it:

     (a) is held over stock in the Acquiring Company or some other Company
         falling within Schedule 9 paragraph 10(b) or (c);

     (b) is a right to acquire such an amount of stock as would have on
         acquisition of the New Option an aggregate market value equal to the
         aggregate market value of the stock which was subject to the Old
         Option upon its release;

     (c) has a subscription price such that the aggregate price payable upon the
         complete exercise equals the aggregate price which would have been
         payable on completion of the Old Option; and

     (d) is otherwise identical to the Old Option.

5.4  The New Option shall, for all other purposes of this Sub Plan, be treated
     as having been acquired at the same time as Old Option.

5.5  Where New Options are granted under this Rule, all references to
     Transgenomic Inc in the 1997 Plan, or this Sub Plan, shall be construed as
     references to the Acquiring Company, or as the case may be, to any other
     company to which the Stock or stock subject to New Options relates.

5.6  For the purposes of this Rule, a person shall be deemed to have Control of
     the Company, if he and others acting in concert with him have obtained
     control of it, within the meaning of section 840 of the UK Income and
     Corporation Taxes Act 1988


<PAGE>


6.   TERMINATION OF OPTIONS

6.1  For the purposes of this Sub Plan, Section 10 of the 1997 Plan shall be
     read as if it contained only the words:

     "An Approved Stock Option may be exercised by the personal representative
     of a deceased Optionee within one year following the date of his death and
     by the Optionee within one year following the date upon which such Optionee
     ceases to hold office or employment with the Company, if such cessation is
     as a result of:

     (a)  permanent or total disability (provided the Optionee has been
          continuously employed by the Company for at least three years or such
          shorter period as the Committee may determine upon the grant of any
          Approved Stock Option);

     (b)  pregnancy;

     (c)  redundancy within the meaning of the UK Employment Rights Act 1996;

     (d)  retirement at the normal age provided that the option has been held
          for at least 2 years at the date of such retirement (or such longer
          period as the Committee may determine upon the grant of any Approved
          Stock Option); or

     (e)  any other reason at the discretion of the Committee.

6.2  Where an Optionee ceases to hold office or employment with the Company for
     any reason other than those set out in Rule 6.1, the Approved Stock Option
     shall lapse, whether or not vested.

7.   MISCELLANEOUS

7.1  Section 11.2 shall not apply to the Sub Plan.

7.2  In the event of any conflict between the terms of the 1997 Plan and this
     Sub Plan, the Sub Plan shall prevail.

7.3  No amendment made to:

     (a)  any Approved Stock Option granted under this Sub Plan;

     (b)  any part of this Sub Plan;

     (c)  any part of the 1997 Plan insofar as those amendments affect this Sub
          Plan,

     shall have any effect until it has been approved by the Board of the UK
     Inland Revenue.

<PAGE>

                                                                    EXHIBIT 10.8

                              EMPLOYMENT AGREEMENT

         THIS AGREEMENT is made as of March 1, 2000, by and between
Transgenomic, Inc., a Delaware corporation (the "Company"), and Collin D'Silva
("Employee").

         The Company and Employee desire to enter into an Employment Agreement
(this "Agreement"). Accordingly, the Company and Employee agree as follows:

         Section 1. EFFECTIVE DATE; POSITION; TERM. This Agreement shall become
effective on March 1, 2000 (the "Effective Date"). The Company shall employ
Employee as Chief Executive Officer. The initial term of the Agreement will be
for a minimum of four (4) years from the Effective Date, and the Agreement may
be extended upon mutual consent of the parties.

         Section 2.  POSITION AND DUTIES.  During the Employment Period:

                  (a) Employee shall have the normal responsibilities, duties
         and authorities of Chief Executive Officer.

                  (b) Employee shall report to the Board of Directors of the
         Company and Employee shall perform faithfully the executive duties
         assigned to him to the best of his ability in a diligent, trustworthy,
         businesslike and efficient manner and will devote his full business
         time and attention to the business and affairs of the Company and its
         Subsidiaries and Affiliates; provided, however, that Employee may serve
         as a director of or a consultant to other corporations which do not
         compete with the Company, nonprofit corporations, civic organizations,
         professional groups and similar entities.

                  (c) For purposes of this Agreement, "Subsidiary" shall mean
         any corporation or other entity of which securities having a majority
         of the voting power in electing directors or comparable management are,
         at the time of determination, owned by the Company, directly or through
         one or more Subsidiaries.

                  (d) For purposes of this Agreement, "Affiliate" of any
         particular person means any other person controlling, controlled by or
         under common control with such particular person.


<PAGE>


         Section 3.  BASIC COMPENSATION.

                  (a) BASE SALARY. As compensation for his services hereunder,
the Company shall pay to Employee during the Employment Period an initial base
salary of $132,000.00 per year.

         Base Salary shall be payable in equal installments in arrears on a
biweekly basis or as otherwise may be mutually agreed upon.

         The salary will be reviewed and determined by the Compensation
Committee of the Board of Directors.

         Section 4. BONUS. In addition to the Base Salary, Employee shall be
eligible to receive an annual bonus based on Employee's performance in
conjunction with specific mutually agreed goals and objectives defined prior to
such calendar year payable at such time or times during or following each
calendar year as shall be determined by the Chief Executive Officer and the
Board of Directors (the "Board") or a committee thereof in its sole discretion
and based on formulas to be determined each year by the Board or such committee
in its sole discretion for the Company's management bonus plan.

         Section 5. PARTICIPATION IN EMPLOYEE BENEFIT PLANS. Employee will be
entitled to participate in all Company salaried employee benefit plans and
programs, subject to the terms and conditions of each such employee benefit plan
or program and to the extent commensurate with his position as Chief Executive
Officer.

         Section 6.  OTHER BENEFITS.

                  (a) VACATION. Employee shall initially be entitled to four
         weeks' paid vacation each year.

                  (b) INSURANCE. The Company shall make available to Employee
         health, hospitalization, major medical insurance and dental insurance
         (including dependent coverage), and other benefits from time to time
         provided to employees.

         Section 7. BUSINESS EXPENSES. The Company shall reimburse Employee for
all reasonable expenses incurred by him in the course of performing his duties
under this Agreement which are consistent with the Company's policies in effect
from time to time with respect to travel, entertainment and other business
expenses, subject to the Company's requirements with respect to report and
documentation of such expenses.

         Section 8.  TERMINATION OF EMPLOYMENT.

                  (a) EVENTS OF TERMINATION AND SEVERANCE PAYMENT. In the event
         that,


2
<PAGE>


         during the term of this Agreement, Employee is discharged for any
         reason other than for Just Cause (as defined below), Employee shall be
         entitled to receive certain payment (the "Severance Payment") following
         termination of employment. Severance Payment will be made at the
         Employees then current base salary for an amount equal to 12 (twelve)
         months' salary.

                  (b) "Just Cause" means embezzlement or misappropriation of
         corporate funds, other acts of dishonesty, significant activities
         materially harmful to the reputation of the Company as reasonably
         defined by the Company, commission of a felony, willful refusal to
         perform or substantial disregard of the duties properly assigned,
         significant violation of any statutory or common law, duty of loyalty
         to the Company or a material violation of Section 10 or 11 below, or
         takes any other action materially detrimental to the best interest of
         the Company as reasonably determined by the Company.

                  (c) EFFECT OF BREACH OF NONCOMPETITION PROVISIONS. In the
         event Employee breaches or otherwise fails to comply with the
         provisions of Section 10 or 11 below, then, in addition to any other
         remedies provided herein or at law or in equity, the Company shall have
         the right to require return of any severance payment made to the
         Employee. Return of such Severance Payment pursuant to the preceding
         sentence shall not relieve Employee's obligations pursuant to Section
         10 or 11 below.

         Section 9. ASSIGNMENT AND SUCCESSION. (a) The rights and obligations of
the Company under this Agreement shall inure to the benefit of and be binding
upon its respective successors and assigns, and Employee's rights and
obligations hereunder shall inure to the benefit of and be binding upon his
successors and permitted assigns, whether so expressed or not.

                  (b) Employee acknowledges that the services to be rendered by
         him hereunder are unique and personal. Accordingly, Employee may not
         pledge or assign any of his rights or delegate any of his duties or
         obligations under this Agreement without the express prior written
         consent of the Company.

                  (c) The Company may not assign its interest in or obligations
         under this Agreement without the prior written consent of Employee.

         Section 10. CONFIDENTIAL INFORMATION. (a) Employee acknowledges that
the information, observations and data obtained by him during the course of his
performance under this Agreement concerning the business or affairs of the
Company and its Subsidiaries is the property of the Company or such Subsidiary,
as the case may be. Therefore, during the Employment Period and at all times
thereafter, Employee will not directly or indirectly use, divulge, furnish or
make accessible to any unauthorized person or use for his own account any
confidential or proprietary information or trade secrets of the Company or any
of its


3
<PAGE>


Subsidiaries without the Board's prior written consent except and to the extent
required by law (and upon prompt written notice of such requirement to the
Company and such Subsidiary) any of such information, observations or data
without the Board's prior written consent unless and to the extent that the
aforementioned matters become generally known to and available for use by the
public other than as a result of Employee's acts or omissions to act. In the
event Employee shall be required by law to make any disclosure as set forth
above, Employee shall promptly notify the Company and such Subsidiary in writing
of the basis for and the extent of the required disclosure and shall cooperate
with the Company and such Subsidiary to preserve in full the confidentiality of
all intellectual property, trade secrets, confidential information and other
proprietary rights of the Company and such Subsidiary. For purposes hereof,
confidential information does not include any information that has become
publicly known are made generally available through no wrongful act of Employee
or of any other person who is subject to a confidentiality agreement with the
Company.

                 (b) Employee agrees to deliver to the Company at the
         termination of his employment, or at any other time upon written
         request by the Company, all memoranda, notes, plans, records, reports
         and other documents relating to the business of the Company and its
         Subsidiaries which he may then possess or have under his control.

         Section 11. COVENANT NOT TO COMPETE. (a) Employee agrees that during
the Employment Period, and for one year after the Termination Date (the
"Noncompete Period"), he will neither directly nor indirectly engage in, have
any interest in, own, manage, operate, control, be connected with as a
stockholder, joint venturer, officer, employee, partner or consultant or invest
or participate in a business competing with any of the businesses then conducted
(or, to the knowledge of Employee, planned to be conducted within one year) by
the Company or any of its successors or then Subsidiaries, within any
geographical area in which the Company or its Subsidiaries engage or plan within
one year to engage in any such businesses. During the Noncompete Period,
Employee shall not directly or indirectly through another entity (i) induce or
attempt to induce any employee of the Company or any Subsidiary to leave the
employ of the Company or such Subsidiary, or in any way interfere with the
relationship between the Company or any Subsidiary and any employee thereof,
(ii) hire any person who was an employee of the Company or any Subsidiary at any
time during the Employment Period or (iii) induce or attempt to induce any
customer, supplier, licensee or other business relation of the Company or any
Subsidiary to cease doing business with the Company or such Subsidiary, or in
any way interfere with the relationship between any such customer, supplier,
licensee or business relation and the Company or any Subsidiary.

                  (b) Nothing contained in this Section 11 shall prevent
         Employee from owning up to a 5% interest in any corporation or entity
         having one or more classes of its securities listed on a national
         securities exchange or publicly traded in the over-the-counter market,
         provided Employee is not actively involved in the operation or
         management of such corporation or entity. Nothing contained herein
         shall prevent Employee from serving as a paid consultant to other
         companies or serving as a


4
<PAGE>


         member of the Board of Directors of other corporations.

                  (c) If, under the circumstances existing at the time of
         enforcement of this Section 11, the period, scope or geographic area
         described in this Section 12 shall be found or held to be unreasonable,
         the parties hereto agree that the maximum period, scope or geographic
         area reasonable under the circumstances shall be substituted for the
         stated period, scope or geographic area.

         Section 12. CONFLICTS OF INTEREST POLICIES. Employee shall diligently
adhere to the Company's Conflict of Interest Policy as adopted by the Board and
in effect from time to time.

         Section 13. ARBITRATION AND EQUITABLE REMEDIES. (a) Except as provide
in Section 13(b) hereof, the parties agree that any dispute or controversy
arising out of, relating to, or concerning the interpretation, construction,
performance or breach of this Agreement, shall be settled by arbitration to be
held in Nebraska, in accordance with the Employment Dispute Resolution rules of
the American Arbitration Association then in effect. The arbitrator may grant
injunctions or other relief in such dispute or controversy and the decision of
the arbitrator shall be final, conclusive and binding on the parties to the
arbitration. Judgment may be entered on the arbitrator's decision in any court
having jurisdiction. The Company and Employee shall each pay one-half of the
costs and expenses of such arbitration, and each shall separately pay the fees
and expenses of their respective legal counsel.

         THIS ARBITRATION CLAUSE CONSTITUTES A WAIVER OF EMPLOYEE'S RIGHT TO A
JURY TRIAL AND RELATES TO THE RESOLUTION OF ALL DISPUTES RELATING TO ALL ASPECTS
OF THE EMPLOYER/EMPLOYEE RELATIONSHIP.

                  (b) Notwithstanding paragraph (a) of this Section 13, the
         parties agree that, in the event of the breach or threatened breach of
         Sections 10, 11 or 12 of this Agreement by Employee, monetary damages
         alone would not be an adequate remedy to the Company and its
         Subsidiaries for the injury that would result from such breach, and
         that the Company and its Subsidiaries shall be entitled to apply to any
         court of competent jurisdiction for specific performance and/or
         injunctive relief (without posting bond or other security) in order to
         enforce or prevent any violation of such provisions of this Agreement.
         Employee further agrees that any such injunctive relief obtained by the
         Company or any of its Subsidiaries shall be in addition to monetary
         damages.

         Section 14. INDEMNIFICATION. The Company agrees to indemnify and hold
harmless Employee for any and all actions taken by Employee in carrying out his
duties under this Agreement.

         Section 15 ENTIRE AGREEMENT. This Agreement represents the entire
agreement


5
<PAGE>


between the parties relating to the subject matters covered hereby and shall
supersede any prior understandings, agreements or representations by or between
the parties, written or oral, which may have related to the subject matter
hereof in any way and shall not be amended or waived except in a writing signed
by the parties hereto.

         Section 16. NOTICES. Any notice or request required or permitted to be
given hereunder shall be in writing and will be deemed to have been given (i)
when delivered personally, sent by telecopy (with hard copy to follow) or
overnight express courier or (ii) five days following mailing by certified or
registered mail, postage prepaid and return receipt requested, to the addresses
below unless another address is specified by such party in writing:
<TABLE>

        <S>                       <C>
        To the Company:           Transgenomic, Inc.
                                  5600 South 42nd Street
                                  Omaha, NE  68107
                                  Telephone:  (402) 738-5480
                                  Telecopy:   (402) 733-1264

        To the Employee:          Collin D'Silva
                                  5600 South 42nd Street
                                  Omaha, NE  68107
                                  Telephone: (402)  738-5480
                                  Telecopy:  (402) 733-1264
</TABLE>

         Section 17. HEADINGS. The article and section headings herein are for
convenience of reference only and shall not define or limit the provisions
hereof.

         Section 18. APPLICABLE LAW. The corporate law of the State of Delaware
will govern all questions concerning the relative rights of the Company and its
stockholders. All other questions concerning the construction, validity and
interpretation of this Agreement shall be governed by the internal laws of the
State of Nebraska.

         Section 19. SEVERABILITY. Whenever possible, each provision of this
Agreement will be interpreted in such manner as to be effective and valid under
applicable law, but if any provision of this Agreement is held prohibited by,
invalid or unenforceable in any respect under applicable law, such provision
will be ineffective only to the extent of such prohibition or invalidity,
without invalidating the remainder of such provision or the remaining provisions
of this Agreement.

         Section 20. AMENDMENTS AND WAIVERS. Any provision of this Agreement may
be amended or waived only with the prior written consent of the Company and
Employee.

         Section 21. NO STRICT CONSTRUCTION. The language used in this Agreement
will be


6
<PAGE>


deemed to be the language chosen by the parties hereto to express their mutual
intent, and no rule of strict construction will be applied against any party
hereto.

         Section 22. COUNTERPARTS. This Agreement may be executed in separate
counterparts, each of which is deemed to be an original and all of which taken
together constitute one and the same agreement.

         Section 23. EMPLOYEE REPRESENTATIONS. Employee hereby represents and
warrants to the Company that (i) the execution, delivery and performance of this
Agreement by Employee does not and will not conflict with, breach, violate or
cause a default under any contract, agreement, instrument, order, judgment or
decree to which Employee is a party or by which he is bound, (ii) Employee is
not a party to or bound by any employment agreement, noncompete agreement or
confidentiality agreement with any other person or entity and (iii) upon the
execution and delivery of this Agreement by the Company, this Agreement shall be
the valid and binding obligation of Employee, enforceable in accordance with its
terms.

         Section 24. SURVIVAL. Sections 10, 11 and 14 shall survive and continue
in full force in accordance with their terms notwithstanding any termination of
the Employment Period.

         IN WITNESS WHEREOF, the Company has caused this Agreement to be signed
by its duly authorized officer and Employee has signed this Agreement as of the
date first written above.

                               TRANSGENOMIC, INC.

                               By /s/Stephen F. Dwyer
                                  ---------------------------
                                  Name:  Stephen F. Dwyer
                                  Title:    Director

                              EMPLOYEE


                              /s/Collin D'Silva
                              ---------------------------
                              Name: Collin D'Silva


7


<PAGE>

                                                                    EXHIBIT 10.9

                              EMPLOYMENT AGREEMENT

         THIS AGREEMENT is made as of March 1, 2000, by and between
Transgenomic, Inc., a Delaware corporation (the "Company"), and John Allbery
("Employee").

         The Company and Employee desire to enter into an Employment Agreement
(this "Agreement"). Accordingly, the Company and Employee agree as follows:

         Section 1. EFFECTIVE DATE; POSITION; TERM. This Agreement shall become
effective on March 1, 2000 (the "Effective Date"). The Company shall employ
Employee as Chief Financial Officer and Managing Director, European Operations.
The initial term of the Agreement will be for a minimum of four (4) years from
the Effective Date, and the Agreement may be extended upon mutual consent of the
parties.

         Section 2. POSITION AND DUTIES. During the Employment Period:

                  (a) Employee shall have the normal responsibilities, duties
         and authorities of Chief Financial Officer and Managing Director,
         European Operations to be defined prior to the Effective Date.

                  (b) Employee shall report to the Chief Executive Officer of
         the Company and Employee shall perform faithfully the executive duties
         assigned to him to the best of his ability in a diligent, trustworthy,
         businesslike and efficient manner and will devote his full business
         time and attention to the business and affairs of the Company and its
         Subsidiaries and Affiliates; provided, however, that Employee may serve
         as a director of or a consultant to other corporations which do not
         compete with the Company, nonprofit corporations, civic organizations,
         professional groups and similar entities.

                  (c) For purposes of this Agreement, "Subsidiary" shall mean
         any corporation or other entity of which securities having a majority
         of the voting power in electing directors or comparable management are,
         at the time of determination, owned by the Company, directly or through
         one or more Subsidiaries.

                  (d) For purposes of this Agreement, "Affiliate" of any
         particular person means any other person controlling, controlled by or
         under common control with such particular person.


<PAGE>


         Section 3. BASIC COMPENSATION.

                  (a) BASE SALARY. As compensation for his services hereunder,
the Company shall pay to Employee during the Employment Period an initial base
salary of $200,000 per year.

         Base Salary shall be payable in equal installments in arrears on a
biweekly basis or as otherwise may be mutually agreed upon.

         The salary shall be increased over the previous year's salary as
mutually agreed to.

         Section 4. BONUS. In addition to the Base Salary, Employee shall be
eligible to receive an annual bonus based on Employee's performance in
conjunction with specific mutually agreed goals and objectives defined prior to
such calendar year payable at such time or times during or following each
calendar year as shall be determined by the Chief Executive Officer and the
Board of Directors (the "Board") or a committee thereof in its sole discretion
and based on formulas to be determined each year by the Board or such committee
in its sole discretion for the Company's management bonus plan.

         Section 5. PARTICIPATION IN EMPLOYEE BENEFIT PLANS. Employee will be
entitled to participate in all Company salaried employee benefit plans and
programs, subject to the terms and conditions of each such employee benefit plan
or program and to the extent commensurate with his position as Chief Financial
Officer and Managing Director, European Operations.

         Section 6. OTHER BENEFITS.

                  (a) VACATION. Employee shall initially be entitled to four
         weeks' paid vacation each year.

                  (b) INSURANCE. The Company shall make available to Employee
                      health, hospitalization, major medical insurance and
                      dental insurance (including dependent coverage), and other
                      benefits from time to time provided to employees,
                      including such coverage reasonably required while living
                      abroad.

                      Cost not to exceed $1,000 per month while living in
                      Europe, to provide health insurance coverage similar to
                      what the Company normally provides its employees.

                  (c) Relocation. Employee shall be entitled to reimbursement
                      of all reasonable costs of relocation back to the U.S.
                      as previously discussed and agreed.


2
<PAGE>


         Section 7. BUSINESS EXPENSES. The Company shall reimburse Employee for
all reasonable expenses incurred by him in the course of performing his duties
under this Agreement which are consistent with the Company's policies in effect
from time to time with respect to travel, entertainment and other business
expenses, subject to the Company's requirements with respect to report and
documentation of such expenses, including temporary office and support costs,
and periodic travel back to the U.S. while living abroad.

         Section 8. STOCK OPTIONS AND OPTION SHARES. Employee shall be granted
100,000 shares at $10.00 per share of options, 20,000 shares to vest immediately
upon starting, and 20,000 shares to vest per year on the anniversary date of
each of the next four years of your employment.

         Section 9. TERMINATION OF EMPLOYMENT.

                  (a) EVENTS OF TERMINATION AND SEVERANCE PAYMENT. In the event
         that, during the term of this Agreement, Employee is discharged for any
         reason other than for Just Cause (as defined below), Employee shall be
         entitled to receive certain payment (the "Severance Payment") following
         termination of employment. Severance Payment will be made at the
         Employees then current base salary for an amount equal to 12 (twelve)
         months' salary. In addition, in case of such discharge, Employee will
         retain all vested stock options. All unvested stock options will lapse.

                  (b) "Just Cause" means embezzlement or misappropriation of
         corporate funds, other acts of dishonesty, significant activities
         materially harmful to the reputation of the Company as reasonably
         defined by the Company, commission of a felony, willful refusal to
         perform or substantial disregard of the duties properly assigned,
         significant violation of any statutory or common law, duty of loyalty
         to the Company or a material violation of Section 11 or 12 below, or
         takes any other action materially detrimental to the best interest of
         the Company as reasonably determined by the Company.

                  (c) EFFECT OF BREACH OF NONCOMPETITION PROVISIONS. In the
         event Employee breaches or otherwise fails to comply with the
         provisions of Section 11 or 12 below, then, in addition to any other
         remedies provided herein or at law or in equity, the Company shall have
         the right to require return of any severance payment made to the
         Employee. Return of such Severance Payment pursuant to the preceding
         sentence shall not relieve Employee's obligations pursuant to Section
         11 or 12 below.


3
<PAGE>


         Section 10. ASSIGNMENT AND SUCCESSION. (a) The rights and obligations
of the Company under this Agreement shall inure to the benefit of and be binding
upon its respective successors and assigns, and Employee's rights and
obligations hereunder shall inure to the benefit of and be binding upon his
successors and permitted assigns, whether so expressed or not.

                  (b) Employee acknowledges that the services to be rendered by
         him hereunder are unique and personal. Accordingly, Employee may not
         pledge or assign any of his rights or delegate any of his duties or
         obligations under this Agreement without the express prior written
         consent of the Company.

                  (c) The Company may not assign its interest in or obligations
         under this Agreement without the prior written consent of Employee.

         Section 11. CONFIDENTIAL INFORMATION. (a) Employee acknowledges that
the information, observations and data obtained by him during the course of his
performance under this Agreement concerning the business or affairs of the
Company and its Subsidiaries is the property of the Company or such Subsidiary,
as the case may be. Therefore, during the Employment Period and at all times
thereafter, Employee will not directly or indirectly use, divulge, furnish or
make accessible to any unauthorized person or use for his own account any
confidential or proprietary information or trade secrets of the Company or any
of its Subsidiaries without the Board's prior written consent except and to the
extent required by law (and upon prompt written notice of such requirement to
the Company and such Subsidiary) any of such information, observations or data
without the Board's prior written consent unless and to the extent that the
aforementioned matters become generally known to and available for use by the
public other than as a result of Employee's acts or omissions to act. In the
event Employee shall be required by law to make any disclosure as set forth
above, Employee shall promptly notify the Company and such Subsidiary in writing
of the basis for and the extent of the required disclosure and shall cooperate
with the Company and such Subsidiary to preserve in full the confidentiality of
all intellectual property, trade secrets, confidential information and other
proprietary rights of the Company and such Subsidiary. For purposes hereof,
confidential information does not include any information that has become
publicly known are made generally available through no wrongful act of Employee
or of any other person who is subject to a confidentiality agreement with the
Company.

                 (b) Employee agrees to deliver to the Company at the
         termination of his employment, or at any other time upon written
         request by the Company, all memoranda, notes, plans, records, reports
         and other documents relating to the business of the Company and its
         Subsidiaries which he may then possess or have under his control.


4
<PAGE>


         Section 12. COVENANT NOT TO COMPETE. (a) Employee agrees that during
the Employment Period, and for one year after the Termination Date (the
"Noncompete Period"), he will neither directly nor indirectly engage in, have
any interest in, own, manage, operate, control, be connected with as a
stockholder, joint venturer, officer, employee, partner or consultant or invest
or participate in a business competing with any of the businesses then conducted
(or, to the knowledge of Employee, planned to be conducted within one year) by
the Company or any of its successors or then Subsidiaries, within any
geographical area in which the Company or its Subsidiaries engage or plan within
one year to engage in any such businesses. During the Noncompete Period,
Employee shall not directly or indirectly through another entity (i) induce or
attempt to induce any employee of the Company or any Subsidiary to leave the
employ of the Company or such Subsidiary, or in any way interfere with the
relationship between the Company or any Subsidiary and any employee thereof,
(ii) hire any person who was an employee of the Company or any Subsidiary at any
time during the Employment Period or (iii) induce or attempt to induce any
customer, supplier, licensee or other business relation of the Company or any
Subsidiary to cease doing business with the Company or such Subsidiary, or in
any way interfere with the relationship between any such customer, supplier,
licensee or business relation and the Company or any Subsidiary.

                  (b) Nothing contained in this Section 12 shall prevent
         Employee from owning up to a 5% interest in any corporation or entity
         having one or more classes of its securities listed on a national
         securities exchange or publicly traded in the over-the-counter market,
         provided Employee is not actively involved in the operation or
         management of such corporation or entity. Nothing contained herein
         shall prevent Employee from serving as a paid consultant to other
         companies or serving as a member of the Board of Directors of other
         corporations.

                  (c) If, under the circumstances existing at the time of
         enforcement of this Section 12, the period, scope or geographic area
         described in this Section 12 shall be found or held to be unreasonable,
         the parties hereto agree that the maximum period, scope or geographic
         area reasonable under the circumstances shall be substituted for the
         stated period, scope or geographic area.

         Section 13. CONFLICTS OF INTEREST POLICIES. Employee shall diligently
adhere to the Company's Conflict of Interest Policy as adopted by the Board and
in effect from time to time.

         Section 14. ARBITRATION AND EQUITABLE REMEDIES. (a) Except as provide
in Section 14(b) hereof, the parties agree that any dispute or controversy
arising out of, relating to, or concerning the interpretation, construction,
performance or breach of this Agreement, shall be settled by arbitration to be
held in Nebraska, in accordance with the Employment Dispute Resolution rules of
the American Arbitration Association then in effect. The arbitrator may grant
injunctions or other relief in such dispute or controversy and the decision of
the


5
<PAGE>


arbitrator shall be final, conclusive and binding on the parties to the
arbitration. Judgment may be entered on the arbitrator's decision in any court
having jurisdiction. The Company and Employee shall each pay one-half of the
costs and expenses of such arbitration, and each shall separately pay the fees
and expenses of their respective legal counsel.

         THIS ARBITRATION CLAUSE CONSTITUTES A WAIVER OF EMPLOYEE'S RIGHT TO A
JURY TRIAL AND RELATES TO THE RESOLUTION OF ALL DISPUTES RELATING TO ALL ASPECTS
OF THE EMPLOYER/EMPLOYEE RELATIONSHIP.

                  (b) Notwithstanding paragraph (a) of this Section 14, the
         parties agree that, in the event of the breach or threatened breach of
         Sections 11, 12 or 13 of this Agreement by Employee, monetary damages
         alone would not be an adequate remedy to the Company and its
         Subsidiaries for the injury that would result from such breach, and
         that the Company and its Subsidiaries shall be entitled to apply to any
         court of competent jurisdiction for specific performance and/or
         injunctive relief (without posting bond or other security) in order to
         enforce or prevent any violation of such provisions of this Agreement.
         Employee further agrees that any such injunctive relief obtained by the
         Company or any of its Subsidiaries shall be in addition to monetary
         damages.

         Section 15. INDEMNIFICATION. The Company agrees to indemnify and hold
harmless Employee for any and all actions taken by Employee in carrying out his
duties under this Agreement.

         Section 16 ENTIRE AGREEMENT. This Agreement represents the entire
agreement between the parties relating to the subject matters covered hereby and
shall supersede any prior understandings, agreements or representations by or
between the parties, written or oral, which may have related to the subject
matter hereof in any way and shall not be amended or waived except in a writing
signed by the parties hereto.

         Section 17. NOTICES. Any notice or request required or permitted to be
given hereunder shall be in writing and will be deemed to have been given (i)
when delivered personally, sent by telecopy (with hard copy to follow) or
overnight express courier or (ii) five days following mailing by certified or
registered mail, postage prepaid and return receipt requested, to the addresses
below unless another address is specified by such party in writing:
<TABLE>

                  <S>                       <C>
                  To the Company:           Transgenomic, Inc.
                                            5600 South 42nd Street
                                            Omaha, NE  68107
                                            Attention:  Chief Executive Officer
                                            Telephone:  (402) 738-5480
                                            Telecopy:   (402) 733-1264
</TABLE>


6
<PAGE>


<TABLE>
                  <S>                       <C>
                  To the Employee:          John L. Allbery
                                            H-1022, Budapest
                                            Endrodi Sandor u. 75/B
                                            Hungary
                                            Telephone: 36-1-200-5415
                                            Telecopy: 36-1-274-0071
</TABLE>

         Section 18. HEADINGS. The article and section headings herein are for
convenience of reference only and shall not define or limit the provisions
hereof.

         Section 19. APPLICABLE LAW. The corporate law of the State of Delaware
will govern all questions concerning the relative rights of the Company and its
stockholders. All other questions concerning the construction, validity and
interpretation of this Agreement shall be governed by the internal laws of the
State of Nebraska.

         Section 20. SEVERABILITY. Whenever possible, each provision of this
Agreement will be interpreted in such manner as to be effective and valid under
applicable law, but if any provision of this Agreement is held prohibited by,
invalid or unenforceable in any respect under applicable law, such provision
will be ineffective only to the extent of such prohibition or invalidity,
without invalidating the remainder of such provision or the remaining provisions
of this Agreement.

         Section 21. AMENDMENTS AND WAIVERS. Any provision of this Agreement may
be amended or waived only with the prior written consent of the Company and
Employee.

         Section 22. NO STRICT CONSTRUCTION. The language used in this Agreement
will be deemed to be the language chosen by the parties hereto to express their
mutual intent, and no rule of strict construction will be applied against any
party hereto.

         Section 23. COUNTERPARTS. This Agreement may be executed in separate
counterparts, each of which is deemed to be an original and all of which taken
together constitute one and the same agreement.

         Section 24. EMPLOYEE REPRESENTATIONS. Employee hereby represents and
warrants to the Company that (i) the execution, delivery and performance of this
Agreement by Employee does not and will not conflict with, breach, violate or
cause a default under any contract, agreement, instrument, order, judgment or
decree to which Employee is a party or by which he is bound, (ii) Employee is
not a party to or bound by any employment agreement, noncompete agreement or
confidentiality agreement with any other person or entity and (iii) upon the
execution and delivery of this Agreement by the Company, this Agreement shall be
the valid and binding obligation of Employee, enforceable in accordance with its
terms.


7
<PAGE>


         Section 25. SURVIVAL. Sections 8, 11, 12 and 15 shall survive and
continue in full force in accordance with their terms notwithstanding any
termination of the Employment Period.

         IN WITNESS WHEREOF, the Company has caused this Agreement to be signed
by its duly authorized officer and Employee has signed this Agreement as of the
date first written above.

                               TRANSGENOMIC, INC.

                                By /s/ Collin D'Silva
                                   ----------------------------------
                                    Name:  Collin D'Silva
                                    Title:  Chief Executive Officer

                                EMPLOYEE



                                /s/ JOHN ALLBERY
                               -------------------------------------------
                               Name: John Allbery

8

<PAGE>

                                                                   EXHIBIT 10.10

                              EMPLOYMENT AGREEMENT

         THIS AGREEMENT is made as of March 1, 2000, by and between
Transgenomic, Inc., a Delaware corporation (the "Company"), and Douglas T.
Gjerde ("Employee").

         The Company and Employee desire to enter into an Employment Agreement
(this "Agreement"). Accordingly, the Company and Employee agree as follows:

         Section 1. EFFECTIVE DATE; POSITION; TERM. This Agreement shall become
effective on March 1, 2000 (the "Effective Date"). The Company shall employ
Employee as Chief Scientific Officer. The initial term of the Agreement will be
for a minimum of four (4) years from the Effective Date, and the Agreement may
be extended upon mutual consent of the parties.

         Section 2.  POSITION AND DUTIES.  During the Employment Period:

                  (a) Employee shall have the normal responsibilities, duties
         and authorities of Chief Scientific Officer.

                  (b) Employee shall report to the Chief Executive Officer of
         the Company and Employee shall perform faithfully the executive duties
         assigned to him to the best of his ability in a diligent, trustworthy,
         businesslike and efficient manner and will devote his full business
         time and attention to the business and affairs of the Company and its
         Subsidiaries and Affiliates; provided, however, that Employee may serve
         as a director of or a consultant to other corporations which do not
         compete with the Company, nonprofit corporations, civic organizations,
         professional groups and similar entities.

                  (c) For purposes of this Agreement, "Subsidiary" shall mean
         any corporation or other entity of which securities having a majority
         of the voting power in electing directors or comparable management are,
         at the time of determination, owned by the Company, directly or through
         one or more Subsidiaries.

                  (d) For purposes of this Agreement, "Affiliate" of any
         particular person means any other person controlling, controlled by or
         under common control with such particular person.


<PAGE>


         Section 3.  BASIC COMPENSATION.

                  (a) BASE SALARY. As compensation for his services hereunder,
the Company shall pay to Employee during the Employment Period an initial base
salary of $120,000.00 per year.

         Base Salary shall be payable in equal installments in arrears on a
biweekly basis or as otherwise may be mutually agreed upon.

         The salary shall be determined by the Chief Executive Officer and
approved by the Compensation Committee of the Board of Directors.

         Section 4. BONUS. In addition to the Base Salary, Employee shall be
eligible to receive an annual bonus based on Employee's performance in
conjunction with specific mutually agreed goals and objectives defined prior to
such calendar year payable at such time or times during or following each
calendar year as shall be determined by the Chief Executive Officer and the
Board of Directors (the "Board") or a committee thereof in its sole discretion
and based on formulas to be determined each year by the Board or such committee
in its sole discretion for the Company's management bonus plan.

         Section 5. PARTICIPATION IN EMPLOYEE BENEFIT PLANS. Employee will be
entitled to participate in all Company salaried employee benefit plans and
programs, subject to the terms and conditions of each such employee benefit plan
or program and to the extent commensurate with his position as Chief Scientific
Officer.

         Section 6.  OTHER BENEFITS.

                  (a) VACATION. Employee shall initially be entitled to four
         weeks' paid vacation each year.

                  (b) INSURANCE. The Company shall make available to Employee
         health, hospitalization, major medical insurance and dental insurance
         (including dependent coverage), and other benefits from time to time
         provided to employees.

         Section 7. BUSINESS EXPENSES. The Company shall reimburse Employee for
all reasonable expenses incurred by him in the course of performing his duties
under this Agreement which are consistent with the Company's policies in effect
from time to time with respect to travel, entertainment and other business
expenses, subject to the Company's requirements with respect to report and
documentation of such expenses.


2
<PAGE>


         Section 8.  TERMINATION OF EMPLOYMENT.

                  (a) EVENTS OF TERMINATION AND SEVERANCE PAYMENT. In the event
         that, during the term of this Agreement, Employee is discharged for any
         reason other than for Just Cause (as defined below), Employee shall be
         entitled to receive certain payment (the "Severance Payment") following
         termination of employment. Severance Payment will be made at the
         Employees then current base salary for an amount equal to 12 (twelve)
         months' salary. In addition, in case of such discharge, Employee will
         retain all vested stock options.

                  (b) "Just Cause" means embezzlement or misappropriation of
         corporate funds, other acts of dishonesty, significant activities
         materially harmful to the reputation of the Company as reasonably
         defined by the Company, commission of a felony, willful refusal to
         perform or substantial disregard of the duties properly assigned,
         significant violation of any statutory or common law, duty of loyalty
         to the Company or a material violation of Section 10 or 11 below, or
         takes any other action materially detrimental to the best interest of
         the Company as reasonably determined by the Company.

                  (c) EFFECT OF BREACH OF NONCOMPETITION PROVISIONS. In the
         event Employee breaches or otherwise fails to comply with the
         provisions of Section 10 or 11 below, then, in addition to any other
         remedies provided herein or at law or in equity, the Company shall have
         the right to require return of any severance payment made to the
         Employee. Return of such Severance Payment pursuant to the preceding
         sentence shall not relieve Employee's obligations pursuant to Section
         10 or 11 below.

         Section 9. ASSIGNMENT AND SUCCESSION. (a) The rights and obligations of
the Company under this Agreement shall inure to the benefit of and be binding
upon its respective successors and assigns, and Employee's rights and
obligations hereunder shall inure to the benefit of and be binding upon his
successors and permitted assigns, whether so expressed or not.

                  (b) Employee acknowledges that the services to be rendered by
         him hereunder are unique and personal. Accordingly, Employee may not
         pledge or assign any of his rights or delegate any of his duties or
         obligations under this Agreement without the express prior written
         consent of the Company.

                  (c) The Company may not assign its interest in or obligations
         under this Agreement without the prior written consent of Employee.

         Section 10. CONFIDENTIAL INFORMATION. (a) Employee acknowledges that
the information, observations and data obtained by him during the course of his
performance


3
<PAGE>


under this Agreement concerning the business or affairs of the Company and its
Subsidiaries is the property of the Company or such Subsidiary, as the case may
be. Therefore, during the Employment Period and at all times thereafter,
Employee will not directly or indirectly use, divulge, furnish or make
accessible to any unauthorized person or use for his own account any
confidential or proprietary information or trade secrets of the Company or any
of its Subsidiaries without the Board's prior written consent except and to the
extent required by law (and upon prompt written notice of such requirement to
the Company and such Subsidiary) any of such information, observations or data
without the Board's prior written consent unless and to the extent that the
aforementioned matters become generally known to and available for use by the
public other than as a result of Employee's acts or omissions to act. In the
event Employee shall be required by law to make any disclosure as set forth
above, Employee shall promptly notify the Company and such Subsidiary in writing
of the basis for and the extent of the required disclosure and shall cooperate
with the Company and such Subsidiary to preserve in full the confidentiality of
all intellectual property, trade secrets, confidential information and other
proprietary rights of the Company and such Subsidiary. For purposes hereof,
confidential information does not include any information that has become
publicly known are made generally available through no wrongful act of Employee
or of any other person who is subject to a confidentiality agreement with the
Company.

                  (b) Employee agrees to deliver to the Company at the
         termination of his employment, or at any other time upon written
         request by the Company, all memoranda, notes, plans, records, reports
         and other documents relating to the business of the Company and its
         Subsidiaries which he may then possess or have under his control.

         Section 11. COVENANT NOT TO COMPETE. (a) Employee agrees that during
the Employment Period, and for one year after the Termination Date (the
"Noncompete Period"), he will neither directly nor indirectly engage in, have
any interest in, own, manage, operate, control, be connected with as a
stockholder, joint venturer, officer, employee, partner or consultant or invest
or participate in a business competing with any of the businesses then conducted
(or, to the knowledge of Employee, planned to be conducted within one year) by
the Company or any of its successors or then Subsidiaries, within any
geographical area in which the Company or its Subsidiaries engage or plan within
one year to engage in any such businesses. During the Noncompete Period,
Employee shall not directly or indirectly through another entity (i) induce or
attempt to induce any employee of the Company or any Subsidiary to leave the
employ of the Company or such Subsidiary, or in any way interfere with the
relationship between the Company or any Subsidiary and any employee thereof,
(ii) hire any person who was an employee of the Company or any Subsidiary at any
time during the Employment Period or (iii) induce or attempt to induce any
customer, supplier, licensee or other business relation of the Company or any
Subsidiary to cease doing business with the Company or such Subsidiary, or in
any way interfere with the relationship between any such customer, supplier,
licensee or business relation and the Company or any Subsidiary.

                  (b) Nothing contained in this Section 11 shall prevent
         Employee from


4
<PAGE>


         owning up to a 5% interest in any corporation or entity having one or
         more classes of its securities listed on a national securities exchange
         or publicly traded in the over-the-counter market, provided Employee is
         not actively involved in the operation or management of such
         corporation or entity. Nothing contained herein shall prevent Employee
         from serving as a paid consultant to other companies or serving as a
         member of the Board of Directors of other corporations.

                  (c) If, under the circumstances existing at the time of
         enforcement of this Section 11, the period, scope or geographic area
         described in this Section 11 shall be found or held to be unreasonable,
         the parties hereto agree that the maximum period, scope or geographic
         area reasonable under the circumstances shall be substituted for the
         stated period, scope or geographic area.

         Section 12. CONFLICTS OF INTEREST POLICIES. Employee shall diligently
adhere to the Company's Conflict of Interest Policy as adopted by the Board and
in effect from time to time.

         Section 13. ARBITRATION AND EQUITABLE REMEDIES. (a) Except as provide
in Section 13(b) hereof, the parties agree that any dispute or controversy
arising out of, relating to, or concerning the interpretation, construction,
performance or breach of this Agreement, shall be settled by arbitration to be
held in Nebraska, in accordance with the Employment Dispute Resolution rules of
the American Arbitration Association then in effect. The arbitrator may grant
injunctions or other relief in such dispute or controversy and the decision of
the arbitrator shall be final, conclusive and binding on the parties to the
arbitration. Judgment may be entered on the arbitrator's decision in any court
having jurisdiction. The Company and Employee shall each pay one-half of the
costs and expenses of such arbitration, and each shall separately pay the fees
and expenses of their respective legal counsel.

         THIS ARBITRATION CLAUSE CONSTITUTES A WAIVER OF EMPLOYEE'S RIGHT TO A
JURY TRIAL AND RELATES TO THE RESOLUTION OF ALL DISPUTES RELATING TO ALL ASPECTS
OF THE EMPLOYER/EMPLOYEE RELATIONSHIP.

                  (b) Notwithstanding paragraph (a) of this Section 13, the
         parties agree that, in the event of the breach or threatened breach of
         Sections 10, 11 or 12 of this Agreement by Employee, monetary damages
         alone would not be an adequate remedy to the Company and its
         Subsidiaries for the injury that would result from such breach, and
         that the Company and its Subsidiaries shall be entitled to apply to any
         court of competent jurisdiction for specific performance and/or
         injunctive relief (without posting bond or other security) in order to
         enforce or prevent any violation of such provisions of this Agreement.
         Employee further agrees that any such injunctive relief obtained by the
         Company or any of its Subsidiaries shall be in addition to monetary
         damages.


5
<PAGE>


         Section 14. INDEMNIFICATION. The Company agrees to indemnify and hold
harmless Employee for any and all actions taken by Employee in carrying out his
duties under this Agreement.

         Section 15 ENTIRE AGREEMENT. This Agreement represents the entire
agreement between the parties relating to the subject matters covered hereby and
shall supersede any prior understandings, agreements or representations by or
between the parties, written or oral, which may have related to the subject
matter hereof in any way and shall not be amended or waived except in a writing
signed by the parties hereto.

         Section 16. NOTICES. Any notice or request required or permitted to be
given hereunder shall be in writing and will be deemed to have been given (i)
when delivered personally, sent by telecopy (with hard copy to follow) or
overnight express courier or (ii) five days following mailing by certified or
registered mail, postage prepaid and return receipt requested, to the addresses
below unless another address is specified by such party in writing:
<TABLE>

       <S>                       <C>
       To the Company:           Transgenomic, Inc.
                                 5600 South 42nd Street
                                 Omaha, NE  68107
                                 Attention:  Chief Executive Officer
                                 Telephone:  (402) 738-5480
                                 Telecopy:   (402) 733-1264

       To the Employee:          Douglas T. Gjerde
                                 2320 Concourse Drive
                                 San Jose, CA  95131
                                 Telephone:  (408) 432-3230
                                 Telecopy:  (408) 432-8910
</TABLE>

         Section 17. HEADINGS. The article and section headings herein are for
convenience of reference only and shall not define or limit the provisions
hereof.

         Section 18. APPLICABLE LAW. The corporate law of the State of Delaware
will govern all questions concerning the relative rights of the Company and its
stockholders. All other questions concerning the construction, validity and
interpretation of this Agreement shall be governed by the internal laws of the
State of Nebraska.


6
<PAGE>


         Section 19. SEVERABILITY. Whenever possible, each provision of this
Agreement will be interpreted in such manner as to be effective and valid under
applicable law, but if any provision of this Agreement is held prohibited by,
invalid or unenforceable in any respect under applicable law, such provision
will be ineffective only to the extent of such prohibition or invalidity,
without invalidating the remainder of such provision or the remaining provisions
of this Agreement.

         Section 20. AMENDMENTS AND WAIVERS. Any provision of this Agreement may
be amended or waived only with the prior written consent of the Company and
Employee.

         Section 21. NO STRICT CONSTRUCTION. The language used in this Agreement
will be deemed to be the language chosen by the parties hereto to express their
mutual intent, and no rule of strict construction will be applied against any
party hereto.

         Section 22. COUNTERPARTS. This Agreement may be executed in separate
counterparts, each of which is deemed to be an original and all of which taken
together constitute one and the same agreement.

         Section 23. EMPLOYEE REPRESENTATIONS. Employee hereby represents and
warrants to the Company that (i) the execution, delivery and performance of this
Agreement by Employee does not and will not conflict with, breach, violate or
cause a default under any contract, agreement, instrument, order, judgment or
decree to which Employee is a party or by which he is bound, (ii) Employee is
not a party to or bound by any employment agreement, noncompete agreement or
confidentiality agreement with any other person or entity and (iii) upon the
execution and delivery of this Agreement by the Company, this Agreement shall be
the valid and binding obligation of Employee, enforceable in accordance with its
terms.

         Section 24. SURVIVAL. Sections 10, 11 and 14 shall survive and continue
in full force in accordance with their terms notwithstanding any termination of
the Employment Period.


7
<PAGE>


         IN WITNESS WHEREOF, the Company has caused this Agreement to be signed
by its duly authorized officer and Employee has signed this Agreement as of the
date first written above.

                               TRANSGENOMIC, INC.

                                By /s/ Collin D'Silva
                                -----------------------------------
                                    Name:  Collin D'Silva
                                    Title:  Chief Executive Officer

                                EMPLOYEE

                                /s/ Douglas T. Gjerde
                                -----------------------------------
                                Name: Douglas T. Gjerde


8

<PAGE>


                                                                   EXHIBIT 10.11

                              EMPLOYMENT AGREEMENT

         THIS AGREEMENT is made as of November 16, 1998 by and between
Transgenomic, Inc., a Delaware corporation (the "Company"), and William B.
Walker ("Employee").

         The Company and Employee desire to enter into an Employment Agreement
(this "Agreement"). Accordingly, the Company and Employee agree as follows:

         Section 1. EFFECTIVE DATE; POSITION; TERM. This Agreement shall become
effective on the date first set forth above (the "Effective Date"). The Company
shall employ Employee as Vice President--Intellectual Property and Assistant
General Counsel of the Company for a term (the "Employment Period") commencing
on November 16, 1998 and continuing until November 16, 2000, unless sooner
terminated pursuant to Section 9 hereof, provided that the Employment Period
shall by mutual agreement be extended on the first anniversary date (November
16, 1999) and on each anniversary date thereafter for the two-year period
following such renewal unless either the Company or Employee delivers to the
other a notice of nonextension.

         Section 2.  POSITION AND DUTIES.  During the Employment Period:

                  (a) Employee shall have the normal responsibilities, duties
         and authorities of Vice President--Intellectual Property and Assistant
         General Counsel.

                  (b) Employee shall report to the General Counsel of the
         Company and Employee shall perform faithfully the executive duties
         assigned to him to the best of his ability in a diligent, trustworthy,
         businesslike and efficient manner and will devote his full business
         time and attention to the business and affairs of the Company and its
         Subsidiaries and Affiliates; provided, however, that Employee may serve
         as a director of or a consultant to other corporations which do not
         compete with the Company, nonprofit corporations, civic organizations,
         professional groups and similar entities.

                  (c) For purposes of this Agreement, "Subsidiary" shall mean
         any corporation or other entity of which securities having a majority
         of the voting power in electing directors or comparable management are,
         at the time of determination, owned by the Company, directly or through
         one or more Subsidiaries.

                  (d) For purposes of this Agreement, "Affiliate" of any
         particular person means any other person controlling, controlled by or
         under common control with such particular person.

         Section 3.  BASIC COMPENSATION.

                  (a) BASE SALARY. As compensation for his services hereunder,
         the Company shall pay to Employee during the Employment Period a base
         salary (the "Base Salary") at the following rates per calendar year:

<PAGE>

<TABLE>
<CAPTION>
                       CALENDAR YEAR                                            ANNUAL BASE SALARY
                       -------------                                            ------------------
           <S>                                                                <C>
            November 16, 1998--December 31, 1998                               $
                                                                               --------------
                            1999                                                     $200,000
</TABLE>

         Base Salary shall be payable in equal installments in arrears on a
biweekly basis or as otherwise may be mutually agreed upon.

         Section 4. BONUS. In addition to the Base Salary, Employee shall be
eligible to receive an annual bonus based on Employee's performance and the
Company's operating results during such calendar year payable at such time or
times during or following each calendar year as shall be determined by the Board
of Directors (the "Board") or a committee thereof in its sole discretion and
based on formulas to be determined each year by the Board or such committee in
its sole discretion for the Company's management bonus plan.

         Section 5. PARTICIPATION IN EMPLOYEE BENEFIT PLANS. Employee will be
entitled to participate in all Company salaried employee benefit plans and
programs, subject to the terms and conditions of each such employee benefit plan
or program and to the extent commensurate with his position as Vice
President--Intellectual Property and Assistant General Counsel of the Company.

         Section 6.  OTHER BENEFITS.

                  (a) VACATION. Employee shall be entitled to a maximum of four
         weeks' paid vacation each year.

                  (b) INSURANCE. The Company shall provide Employee with health,
                  hospitalization, dental and major medical insurance (including
                  dependent coverage) and other similar benefits.

         Section 7. BUSINESS EXPENSES. The Company shall reimburse Employee for
all reasonable expenses incurred by him in the course of performing his duties
under this Agreement which are consistent with the Company's policies in effect
from time to time with respect to travel, entertainment and other business
expenses, subject to the Company's requirements with respect to report and
documentation of such expenses.

         Section 8. STOCK OPTIONS AND OPTION SHARES. Employee shall be eligible
to participate in the Company's 1997 Stock Option Plan, as amended.

         Section 9.  TERMINATION OF EMPLOYMENT.

                  (a) EVENTS OF TERMINATION AND SEVERANCE PAYMENTS. In the event
         that during the Employment Period Employee should become Totally and
         Permanently Disabled, the Company (acting by resolution of the Board)
         may elect to terminate the Employment Period by written notice to
         Employee and Employee shall be entitled to receive full compensation
         pursuant to subsection 3(a) at his then Base Salary rate for a period
         of six months following



                                       2
<PAGE>

         the date of such notice. In the event of Employee's death during the
         Employment Period, his personal representative shall be entitled to
         receive any compensation pursuant to Sections 3 and 4 which is accrued
         and unpaid as of the date of his death plus six months of salary. In
         the event that during the Employment Period Employee should commit
         Serious Misconduct (as defined in subsection 9(b)(ii) below), the
         Company (acting by resolution of the Board) may elect to terminate the
         Employment Period by written notice to Employee. In the event that
         Employee is discharged for any reason other than for Serious
         Misconduct, Employee shall be entitled to receive certain payments (the
         "Severance Payments") following termination of employment in an
         aggregate amount equal to the Severance Amount listed below:

                                SEVERANCE AMOUNT

                           Since this Employment Agreement is subject to renewal
                  on each anniversary date (November 16, 1999 and each November
                  16 thereafter) on a rolling two-year period following such
                  renewal the Severance Amount shall be equal to such amount
                  remaining to be paid on the balance of this Employment
                  Agreement based on his current base salary so long as the
                  total amount payable does not exceed 299% of the then current
                  base salary. Such amounts to be paid in equal semi-monthly
                  payments in the amounts and on the Company's regularly
                  scheduled employee pay periods.

                  (b) DEFINITION OF CERTAIN TERMS. (i) "Totally and Permanently
         Disabled" means such physical or mental condition of Employee as is
         determined by the Board in its sole discretion to be expected to
         continue indefinitely and which renders him incapable of performing any
         substantial portion of the services contemplated hereby (as confirmed
         by competent medical evidence).

                  (ii) "Serious Misconduct" means embezzlement or
         misappropriation of corporate funds, other acts of dishonesty,
         significant activities materially harmful to the reputation of the
         Company, commission of a felony, willful refusal to perform or
         substantial disregard of the duties properly assigned by the Board,
         significant violation of any statutory or common law duty of loyalty to
         the Company or a material violation of Section 11 or 12 below.

                  (iii) "Termination Date" means the date on which Employee's
         employment with the Company and its Subsidiaries is terminated, whether
         on account of death, disability, resignation or discharge.

                  (c) EFFECT OF BREACH OF NONCOMPETITION PROVISIONS. In the
         event Employee breaches or otherwise fails to comply with the
         provisions of Section 11 or 12 below, then, in addition to any other
         remedies provided herein or at law or in equity, the Company shall not
         have any further obligation to make any additional Severance Payments.
         Termination of such Severance Payments pursuant to the preceding
         sentence shall not relieve Employee's obligations pursuant to Section
         11 or 12 below.

                                       3
<PAGE>

         Section 10. ASSIGNMENT AND SUCCESSION. (a) The rights and obligations
of the Company under this Agreement shall inure to the benefit of and be binding
upon its respective successors and assigns, and Employee's rights and
obligations hereunder shall inure to the benefit of and be binding upon his
successors and permitted assigns, whether so expressed or not.

         (b) Employee acknowledges that the services to be rendered by him
hereunder are unique and personal. Accordingly, Employee may not pledge or
assign any of his rights or delegate any of his duties or obligations under this
Agreement without the express prior written consent of the Company.

         (c) The Company may not assign its interest in or obligations under
this Agreement without the prior written consent of Employee.

         Section 11. CONFIDENTIAL INFORMATION. (a) Employee acknowledges that
the information, observations and data obtained by him during the course of his
performance under this Agreement concerning the business or affairs of the
Company and its Subsidiaries is the property of the Company or such Subsidiary,
as the case may be. Therefore, during the Employment Period and at all times
thereafter, Employee will not directly or indirectly use, divulge, furnish or
make accessible to any unauthorized person or use for his own account any
confidential or proprietary information or trade secrets of the Company or any
of its Subsidiaries without the Board's prior written consent except and to the
extent required by law (and upon prompt written notice of such requirement to
the Company and such Subsidiary) any of such information, observations or data
without the Board's prior written consent unless and to the extent that the
aforementioned matters become generally known to and available for use by the
public other than as a result of Employee's acts or omissions to act. In the
event Employee shall be required by law to make any disclosure as set forth
above, Employee shall promptly notify the Company and such Subsidiary in writing
of the basis for and the extent of the required disclosure and shall cooperate
with the Company and such Subsidiary to preserve in full the confidentiality of
all intellectual property, trade secrets, confidential information and other
proprietary rights of the Company and such Subsidiary. For purposes hereof,
confidential information does not include any information that has become
publicly known and made generally available through no wrongful act of Employee
or of any other person who is subject to a confidentiality agreement with the
Company.

         (b) Employee agrees to deliver to the Company at the termination of his
employment, or at any other time upon written request by the Company, all
memoranda, notes, plans, records, reports and other documents relating to the
business of the Company and its Subsidiaries which he may then possess or have
under his control.

         Section 12. COVENANT NOT TO COMPETE. (a) Employee agrees that during
the Employment Period, and for one year after the Termination Date (the
"Noncompete Period"), he will neither directly nor indirectly engage in, have
any interest in, own, manage, operate, control, be connected with as a
stockholder, joint venturer, officer, employee, partner or consultant or invest
or participate in a business competing with any of the businesses then conducted
(or, to the knowledge of Employee, planned to be conducted within one year) by
the Company or any of its successors or then Subsidiaries, within any
geographical area in which the Company or its Subsidiaries engage or plan within
one year to engage in any such businesses. During the



                                       4
<PAGE>

Noncompete Period, Employee shall not directly or indirectly through another
entity (i) induce or attempt to induce any employee of the Company or any
Subsidiary to leave the employ of the Company or such Subsidiary, or in any way
interfere with the relationship between the Company or any Subsidiary and any
employee thereof, (ii) hire any person who was an employee of the Company or any
Subsidiary at any time during the Employment Period or (iii) induce or attempt
to induce any customer, supplier, licensee or other business relation of the
Company or any Subsidiary to cease doing business with the Company or such
Subsidiary, or in any way interfere with the relationship between any such
customer, supplier, licensee or business relation and the Company or any
Subsidiary.

         (b) Nothing contained in this Section 12 shall prevent Employee from
owning up to a 5% interest in any corporation or entity having one or more
classes of its securities listed on a national securities exchange or publicly
traded in the over-the-counter market, provided Employee is not actively
involved in the operation or management of such corporation or entity. Nothing
contained herein shall prevent Employee from serving as a paid consultant to
other companies or serving as a member of the Board of Directors of other
corporations.

         (c) If, under the circumstances existing at the time of enforcement of
this Section 12, the period, scope or geographic area described in this Section
12 shall be found or held to be unreasonable, the parties hereto agree that the
maximum period, scope or geographic area reasonable under the circumstances
shall be substituted for the stated period, scope or geographic area.

         Section 13. CONFLICTS OF INTEREST POLICIES. Employee shall diligently
adhere to the Company's Conflict of Interest Policy as adopted by the Board and
in effect from time to time.

         Section 14. ARBITRATION AND EQUITABLE REMEDIES. (a) Except as provided
in Section 14(b) hereof, the parties agree that any dispute or controversy
arising out of, relating to, or concerning the interpretation, construction,
performance or breach of this Agreement, shall be settled by arbitration to be
held in Nebraska, in accordance with the Employment Dispute Resolution rules of
the American Arbitration Association then in effect. The arbitrator may grant
injunctions or other relief in such dispute or controversy and the decision of
the arbitrator shall be final, conclusive and binding on the parties to the
arbitration. Judgment may be entered on the arbitrator's decision in any court
having jurisdiction. The Company and Employee shall each pay one-half of the
costs and expenses of such arbitration, and each shall separately pay the fees
and expenses of their respective legal counsel.

         THIS ARBITRATION CLAUSE CONSTITUTES A WAIVER OF EMPLOYEE'S RIGHT TO A
JURY TRIAL AND RELATES TO THE RESOLUTION OF ALL DISPUTES RELATING TO ALL ASPECTS
OF THE EMPLOYER/EMPLOYEE RELATIONSHIP.

         (b) Notwithstanding paragraph (a) of this Section 14, the parties agree
that, in the event of the breach or threatened breach of Sections 11, 12 or 13
of this Agreement by Employee, monetary damages alone would not be an adequate
remedy to the Company and its Subsidiaries for the injury that would result from
such breach, and that the Company and its Subsidiaries shall be entitled to
apply to any court of competent jurisdiction for specific performance and/or
injunctive relief (without posting bond or other security) in order to enforce

                                       5
<PAGE>

or prevent any violation of such provisions of this Agreement. Employee further
agrees that any such injunctive relief obtained by the Company or any of its
Subsidiaries shall be in addition to monetary damages.

         Section 15. ENTIRE AGREEMENT. This Agreement represents the entire
agreement between the parties relating to the subject matters covered hereby and
shall supersede any prior understandings, agreements or representations by or
between the parties, written or oral, which may have related to the subject
matter hereof in any way and shall not be amended or waived except in a writing
signed by the parties hereto.

         Section 16. NOTICES. Any notice or request required or permitted to be
given hereunder shall be in writing and will be deemed to have been given (i)
when delivered personally, sent by telecopy (with hard copy to follow) or
overnight express courier or (ii) five days following mailing by certified or
registered mail, postage prepaid and return receipt requested, to the addresses
below unless another address is specified by such party in writing:

                  To the Company:           Transgenomic, Inc.
                                            5600 South 42nd Street
                                            Omaha, NE  68107
                                            Attention:  Chief Executive Officer
                                            Telephone:  (402) 738-5408
                                            Telecopy:   (402) 733-1264

         Section 17. HEADINGS. The article and section headings herein are for
convenience of reference only and shall not define or limit the provisions
hereof.

         Section 18. APPLICABLE LAW. The corporate law of the State of Delaware
will govern all questions concerning the relative rights of the Company and its
stockholders. All other questions concerning the construction, validity and
interpretation of this Agreement shall be governed by the internal laws of the
State of Nebraska.

         Section 19. SEVERABILITY. Whenever possible, each provision of this
Agreement will be interpreted in such manner as to be effective and valid under
applicable law, but if any provision of this Agreement is held prohibited by,
invalid or unenforceable in any respect under applicable law, such provision
will be ineffective only to the extent of such prohibition or invalidity,
without invalidating the remainder of such provision or the remaining provisions
of this Agreement.

         Section 20. AMENDMENTS AND WAIVERS. Any provision of this Agreement may
be amended or waived only with the prior written consent of the Company and
Employee.

         Section 21. NO STRICT CONSTRUCTION. The language used in this Agreement
will be deemed to be the language chosen by the parties hereto to express their
mutual intent, and no rule of strict construction will be applied against any
party hereto.

         Section 22. COUNTERPARTS. This Agreement may be executed in separate
counterparts, each of which is deemed to be an original and all of which taken
together constitute one and the same agreement.

                                       6
<PAGE>

         Section 23. EMPLOYEE REPRESENTATIONS. Employee hereby represents and
warrants to the Company that (i) the execution, delivery and performance of this
Agreement by Employee does not and will not conflict with, breach, violate or
cause a default under any contract, agreement, instrument, order, judgment or
decree to which Employee is a party or by which he is bound, (ii) Employee is
not a party to or bound by any employment agreement, noncompete agreement or
confidentiality agreement with any other person or entity and (iii) upon the
execution and delivery of this Agreement by the Company, this Agreement shall be
the valid and binding obligation of Employee, enforceable in accordance with its
terms.

         Section 24. SURVIVAL. Sections 8, 11 and 12 shall survive and continue
in full force in accordance with their terms notwithstanding any termination of
the Employment Period.

         IN WITNESS WHEREOF, the Company has caused this Agreement to be signed
by its duly authorized officer and Employee has signed this Agreement as of the
date first written above.

                                        TRANSGENOMIC, INC.

                                        By /s/ Collin D'Silva
                                           -------------------------------------
                                           Name    Collin D'Silva
                                                --------------------------------
                                           Title      Chief Executive Officer
                                                 -------------------------------

                                        EMPLOYEE

                                        /s/ William B. Walker
                                        ----------------------------------------
                                        Name:  William B. Walker

                                       7

<PAGE>

                                                                   EXHIBIT 10.12

                            [TRANSGENOMIC LETTERHEAD]

                                            February 18, 2000

Mr. Gregory J. Duman
17540 Bay Wood Circle
Omaha, NE  68130

Dear Greg:

                  From time to time we have discussed with our officers and
directors the substantial increase in corporate litigation which can subject
officers and directors to expensive litigation risks and large claims for
damages. We have also discussed the uncertainties involved in obtaining and
maintaining directors' and officers' liability insurance on a reasonable basis
and the limited scope of the coverage of such insurance as can be obtained.

                  You have informed us that you are concerned about the level of
protection available to you as an officer or director of Transgenomic, Inc., a
Delaware corporation ("Transgenomic") in the present legal climate, and we
understand that your willingness to continue to serve as an officer or director
of Transgenomic depends upon, among other things, assurance of adequate
protection on a long-term basis. You have also informed us that you know of no
pending or threatened claim against you relating to Transgenomic.

                  In order to attract and retain your services as an officer or
Director of Transgenomic, Transgenomic has agreed to indemnify you to the
fullest extent of its authority to do so, subject to the limitations set forth
herein. This letter agreement ("Agreement") is intended to set forth our
agreement with respect to your right to indemnification by Transgenomic.

                  Transgenomic and you (the "Indemnitee") hereby agree as
follows:

                  1. INDEMNIFICATION. Transgenomic shall indemnify Indemnitee if
Indemnitee is or was a party or is threatened to be made a party to or is
otherwise involved with any threatened, pending or completed action or
proceeding, whether civil, criminal, administrative or investigative, for
actions performed by or inaction on the part of Indemnitee with respect to
occurrences taking place when or by reason of the fact that (i) Indemnitee is or
was a director, officer, employee or agent of Transgenomic, or any subsidiary of
Transgenomic, (ii) Indemnitee is or was serving at the request of Transgenomic
as a director, officer, employee or agent of another corporation, partnership,
joint venture, trust or other enterprise, or (iii) Indemnitee is or was serving
at the request of Transgenomic in any capacity with respect to any employee
benefit plan, against any "Loss or Expense" (as hereinafter defined). As used in
this


<PAGE>


Agreement Loss and Expense shall mean all (x) expenses (including attorney's
fees), (y) judgments, fines, penalties, and (z) losses, claims, damages or
liabilities, including without limitation amounts paid in settlement (but only
if such settlement is approved in advance in writing by Transgenomic, which
approval shall not be unreasonably withheld) actually and reasonably incurred by
Indemnitee in connection with such action or proceeding. Notwithstanding the
foregoing, no indemnification shall be paid under this Agreement with respect to
claims involving acts or omissions as to which Indemnitee is finally adjudicated
(by court order or judgment from which no right of appeal exists) not to have
acted in good faith in the reasonable belief that Indemnitee's action was in (or
not opposed to) the best interests of Transgenomic or, to the extent that such
matter relates to service with respect to an employee benefit plan, in the best
interests of the participants or beneficiaries of such employee benefit plan.

                  2. NO EMPLOYMENT AGREEMENT. In consideration of the protection
afforded by this Agreement, Indemnitee agrees not to resign voluntarily from the
position now held by him with Transgenomic without first giving to Transgenomic
not less than three weeks' written notice of his intention to resign. Nothing
contained in this Agreement is intended to create or shall create in Indemnitee
any right to employment (in the case of a director) or continued employment (in
the case of an employee).

                  3. EXPENSES; INDEMNIFICATION PROCEDURE.

                     (a) ADVANCEMENT OF EXPENSES. Transgenomic shall advance all
expenses reasonably incurred by Indemnitee in connection with the defense of any
threatened or actual civil or criminal action or proceeding described in Section
1 hereof. If Indemnitee shall be adjudicated by a court order or judgment from
which no right of appeal exists to be not entitled to indemnification by
Transgenomic as authorized hereby, Indemnitee hereby undertakes to promptly
repay all such amounts advanced by Transgenomic. The advances to be made
hereunder shall be paid by Transgenomic to Indemnitee within twenty (20) days
following delivery of a written request therefor by Indemnitee to Transgenomic.
If for any reason the Indemnitee is not an employee of Transgenomic at the time
of any activities performed by the Indemnitee in connection with the defense of
any civil or criminal action or proceeding described in Section 1 hereof,
Transgenomic shall compensate the Indemnitee on the basis of $500 per day (or
portion thereof) spent by the Indemnitee on behalf of such activities at the
request of Transgenomic, and reimburse the Indemnitee for all related and
reasonable out-of-pocket expenses, such compensation and expense reimbursement
to be advanced in the manner set forth in Section 3(c) .

                     (b) NOTICE;  COOPERATION BY INDEMNITEE.  Indemnitee shall
give Transgenomic prompt notice of the commencement of any action or proceeding,
or the threat thereof against Indemnitee, for which indemnification will or
could be sought under this Agreement. In addition, Indemnitee shall give
Transgenomic such information and cooperation as it may reasonably require and
as shall be within Indemnitee's power. Transgenomic shall not be liable to
indemnify Indemnitee under this Agreement for any amounts paid in settlement of
any action or claim effected without its written consent, which consent shall
not be unreasonably withheld or delayed.


<PAGE>


                     (c) PROCEDURE.

                         (1) Any amounts  payable by  Transgenomic  pursuant to
the indemnification provided for in Section 1 shall be paid no later than twenty
(20) days after receipt of the written request of Indemnitee. If a claim is
brought by Indemnitee under this Agreement, under any statute, or under any
provision of Transgenomic's Charter or By-laws, as amended or restated from time
to time (the "By-laws"), which provision provides for indemnification, and if
such claim is not paid in full by Transgenomic within twenty (20) days after a
written request by Indemnitee for payment thereof was first received by
Transgenomic, Indemnitee may, but need not, at any time thereafter bring an
action against Transgenomic to recover the unpaid amount of the claim and,
subject to Section 18 of this Agreement, Indemnitee shall also be entitled to be
reimbursed for the expense (including reasonable attorneys' fees) of bringing
such action. It shall be a defense to any such action (other than an action
brought to enforce a claim for expenses incurred in connection with any action
or proceeding in advance of its final disposition) that Indemnitee has not met
the standards of conduct which make it permissible under applicable law for
Transgenomic to indemnify Indemnitee for the amount claimed, but the burden of
proving such defense shall be on Transgenomic, and Indemnitee shall be entitled
to receive interim payments of expenses pursuant to Section 3(a) unless and
until such defense shall be finally adjudicated by court order or judgment from
which no further right of appeal exists.

                         (2) If Transgenomic refuses or rejects Indemnitee's
claim for indemnification hereunder, and in the event the Indemnitee shall
thereafter seek judicial enforcement of this Agreement, neither the failure of
Transgenomic (including its Board of Directors, any committee or subgroup of the
Board of Directors, or independent legal counsel) to have made a determination
that indemnification of Indemnitee is proper in the circumstances because
Indemnitee has met the applicable standard of conduct required by applicable
law, nor an actual determination by Transgenomic (including its Board of
Directors, any committee or subgroup of the Board of Directors, or independent
legal counsel) that Indemnitee has not met such applicable standard of conduct,
shall create a presumption that Indemnitee has or has not met the applicable
standard of conduct.

                  4. NOTICE TO INSURERS. If, at the time of the receipt of a
notice of a prospective claim pursuant to Section 3(b) hereof, Transgenomic has
in effect any insurance, including, without limitation, director and officer
liability insurance, which may provide for payment of or reimbursement for such
claim, Transgenomic shall give prompt notice of the assertion of such claim to
each issuer of such insurance in accordance with the procedures set forth in the
respective policies. Transgenomic shall thereafter (if it is appropriate to do
so pursuant to the terms of the applicable insurance policy) take all necessary
or desirable action to cause such insurers to pay, on behalf of the Indemnitee,
all amounts payable as a result of such proceeding in accordance with the terms
of such policies.

                  5. PRIMARY INDEMNITY. Transgenomic's obligation to provide
indemnification to the Indemnitee under this Agreement is intended to be the
Indemnitee's primary source of indemnification for the expenses and other
liabilities payable to Indemnitee hereunder, notwithstanding the fact that
Indemnitee may provide services to Transgenomic at the request or direction of
any other person or entity and may be entitled to indemnification from, or to
the proceeds of insurance purchased and maintained for Indemnitee's benefit by,
such other person or entity; it being understood, however, that nothing
contained in this subsection shall be

<PAGE>

deemed to enlarge the scope of Transgenomic's obligation to provide
indemnification as provided elsewhere herein.

                  6. SELECTION OF COUNSEL. In the event Transgenomic shall be
obligated under Section 3(a) hereof to pay the expenses of any proceeding or
threatened proceeding against Indemnitee, Transgenomic shall be entitled to
participate in such proceeding and, to the extent it shall wish, to assume the
defense of such proceeding, with counsel chosen by Transgenomic and approved by
Indemnitee, which approval shall not be unreasonably withheld. Upon the delivery
to Indemnitee of written notice of its election to assume such defense, approval
of such counsel by Indemnitee and retention of such counsel by Transgenomic,
Transgenomic will not be liable to Indemnitee under this Agreement for any fees
of counsel or other expenses subsequently incurred by Indemnitee in connection
with the defense of the same proceeding, except for fees and expenses incurred
by Indemnitee as a consequence of Indemnitee's obligation to cooperate with
Transgenomic in the defense of such matters (as set forth in Section 3 hereof).
Notwithstanding the foregoing, the reasonable fees and expenses of Indemnitee's
counsel shall be paid by Transgenomic if (i) the employment of counsel by
Indemnitee has been previously authorized by Transgenomic, (ii) Indemnitee shall
have reasonably concluded that there may be a conflict of interest between
Transgenomic and Indemnitee in the conduct of such defense or that such counsel
and Indemnitee have fundamental and material disagreements as to the proper
method of managing the litigation, or (iii) Transgenomic shall not, in fact,
have employed counsel to assume the defense of such proceeding. Indemnitee shall
have the right to employ his own counsel in any such proceeding at Indemnitee's
expense.

                  7. ADDITIONAL INDEMNIFICATION RIGHTS; NONEXCLUSIVITY.

                     (a) SCOPE.  Notwithstanding  any other provision of this
Agreement, Transgenomic hereby agrees to indemnify the Indemnitee to the fullest
extent permitted by law with respect to any claim, action or proceeding
described in Section 1 hereof, whether or not such indemnification is
specifically authorized by the other provisions of this Agreement,
Transgenomic's Charter or By-laws, or by other statutes. In the event of any
change, after the date of this Agreement, in any applicable law, statute or rule
which expands the right of a Delaware corporation such as Transgenomic to
indemnify a member of its board of directors or an officer, such changes shall,
without any further action by Transgenomic, be included within the scope of the
indemnification provided to Indemnitee by, and Transgenomic's obligations under,
this Agreement. In the event of any change in any applicable law, statute or
rule that limits or restricts the right of Transgenomic to indemnify a member of
its Board of Directors or an officer, such changes shall have no effect on this
Agreement or the parties' rights and obligations hereunder, except to the extent
specifically required by such law, statute or rule to be applied to this
Agreement.

                     (b) NONEXCLUSIVITY. The indemnification provided by this
Agreement shall not be deemed exclusive of any rights to which Indemnitee may be
entitled under Transgenomic's Charter or By-laws, any agreement, any vote of
disinterested directors, applicable law, or otherwise. The indemnification
provided under this Agreement shall continue as to Indemnitee for any action
taken or not taken while serving in an indemnified capacity even though the
Indemnitee may have ceased to serve in such capacity at the time of commencement
of any claim or action for which indemnification is requested.

                  8. PARTIAL INDEMNIFICATION. If Indemnitee is entitled under
any provision of this Agreement to indemnification by Transgenomic for some or a
portion of the expenses,

<PAGE>

judgments, fines or penalties actually or reasonably incurred by him in the
investigation, defense, appeal or settlement of any civil or criminal action or
proceeding, but not, however, for the total amount thereof, Transgenomic shall
nevertheless indemnify Indemnitee for the portion of such expenses, judgments,
fines or penalties to which Indemnitee is entitled.

                  9. MUTUAL ACKNOWLEDGMENT. Both Transgenomic and Indemnitee
acknowledge that in certain instances, applicable law or applicable public
policy could be construed to prohibit Transgenomic from indemnifying its
directors and officers under this Agreement or otherwise. Nothing in this
Agreement is intended to require or shall be construed as requiring Transgenomic
to do or fail to do any act in violation of any applicable law. Transgenomic's
inability, as a result of a binding order of any court of competent
jurisdiction, to perform its obligations under this Agreement shall not
constitute a breach of this Agreement and Transgenomic's compliance with any
such order shall constitute compliance with this Agreement.

                  10. DIRECTORS' AND OFFICERS' LIABILITY INSURANCE. Transgenomic
shall, from time to time, make the good faith determination whether or not it is
practicable for Transgenomic to obtain and maintain a policy or policies of
insurance with reputable insurance companies providing the officers and
directors of Transgenomic with coverage for losses from wrongful acts, or to
ensure Transgenomic's performance of its indemnification obligations under this
Agreement. Among other matters, Transgenomic may consider the costs of obtaining
such insurance coverage, the protection afforded by such coverage and the
restrictions or other terms required by such insurance. In all policies of
directors' and officers' liability insurance, Indemnitee shall be named as an
insured in such a manner as to provide Indemnitee the same rights and benefits
as are accorded to the most favorably insured of Transgenomic's directors, if
Indemnitee is a director, or of Transgenomic's officers, if Indemnitee is not a
director of Transgenomic but is an officer, or of Transgenomic's key employees,
if Indemnitee is not an officer or director but is a key employee.
Notwithstanding the foregoing, Transgenomic shall have no obligation to obtain
or maintain such insurance if Transgenomic determines in good faith that such
insurance is not reasonably available, if the premium costs for such insurance
are disproportionate to the amount of coverage provided, if the coverage
provided by such insurance is limited by exclusions so as to provide an
insufficient benefit, or if Indemnitee is covered by similar insurance
maintained by a subsidiary or parent of Transgenomic.

                  11. SEVERABILITY. The provisions of this Agreement shall be
severable as provided in this Section 11. If this Agreement or any portion
hereof shall be invalidated on any ground by any court of competent
jurisdiction, then Transgenomic shall nevertheless indemnify Indemnitee to the
greatest extent permitted by any applicable law or any applicable portion of
this Agreement that shall not have been invalidated, and the balance of this
Agreement not so invalidated shall be enforceable in accordance with its terms.

                  12. EXCEPTIONS. Any other provision herein to the contrary
notwithstanding, Transgenomic shall not be obligated pursuant to the terms of
this Agreement:

                      (a) EXCLUDED ACTS. To indemnify Indemnitee for any acts or
omissions or transactions from which a director or officer may not be relieved
of liability under applicable Delaware law; or

                      (b) CLAIMS INITIATED BY INDEMNITEE. To indemnify or
advance expenses to Indemnitee with respect to proceedings or claims initiated
or brought voluntarily by


<PAGE>

Indemnitee and not by way of defense, except (i) with respect to proceedings
brought to establish or enforce a right to indemnification under this Agreement
or any other statute or law and (ii) declaratory judgment or similar proceedings
brought to obtain a judicial interpretation of an applicable statute or
regulation, provided that such indemnification or advancement of expenses may be
provided by Transgenomic in specific cases if the Board of Directors has
approved the initiation or bringing of such suit; or

                      (c) LACK OF GOOD FAITH. To indemnify Indemnitee for any
expenses incurred by the Indemnitee with respect to any proceeding instituted by
Indemnitee to enforce or interpret this Agreement, if a court of competent
jurisdiction determines that each of the material assertions made by the
Indemnitee in such proceeding was not made in good faith or was frivolous; or

                      (d) INSURED CLAIMS. To indemnify Indemnitee for expenses
or liabilities of any type whatsoever (including, but not limited to, judgments,
fines, ERISA excise taxes or penalties, and amounts paid in settlement) which
have been reimbursed directly to Indemnitee by an insurance carrier under a
policy of directors' and officers' liability insurance maintained by
Transgenomic.

                  13. SALE OF ASSETS. If Transgenomic is merged into or
consolidated with another corporation and Transgenomic is not the surviving
corporation, or if substantially all of the assets of Transgenomic are acquired
by any other corporation, or in the event of any other similar reorganization
involving Transgenomic, Transgenomic shall to the extent possible cause the
acquiring corporation to assume the obligations of Transgenomic under this
Agreement with respect to Indemnitee.

                  14. EFFECTIVENESS OF AGREEMENT. This Agreement shall be
effective as of the date set forth on the first page hereof and shall continue
in effect from through the time period described in Section 15 hereof. In
addition this Agreement shall also apply to acts or omissions of Indemnitee
which occurred prior to such date if Indemnitee was a director, officer,
employee or other agent of Transgenomic, or was serving at the request of
Transgenomic as a director, officer, employee or agent of another corporation,
partnership, joint venture, trust or other enterprise, or in any other capacity
set forth in Section 1 above, at the time such act or omission occurred.

                  15. DURATION OF AGREEMENT. This Agreement shall continue until
and terminate upon the later of: (a) ten years after Indemnitee has ceased to
serve in any of the capacities set forth in Section 1 above; and (b) the final
termination of all pending or threatened actions, suits, proceedings or
investigations to which Indemnitee may be subject by reason of his service in
any such capacity. The indemnification provided under this Agreement shall
continue as to Indemnitee even though he may have ceased to be a director,
officer, employee or agent of Transgenomic.

                  16. COUNTERPARTS. This Agreement may be executed in one or
more counterparts, each of which shall constitute an original.

                  17. SUCCESSORS AND ASSIGNS. This Agreement shall be binding
upon Transgenomic and its successors and assigns, and shall inure to the benefit
of Indemnitee and Indemnitee's spouse, estate, heirs and legal representatives.

<PAGE>

                  18. ATTORNEYS' FEES. In the event that any action is
instituted by Indemnitee under this Agreement to enforce or interpret any of the
terms hereof, Indemnitee shall be entitled to be paid all court costs and
expenses, including reasonable attorneys' fees, incurred by Indemnitee with
respect to such action, unless as a part of such action, a court of competent
jurisdiction determines that each of the material assertions made by Indemnitee
as a basis for such action was not made in good faith or was frivolous. In the
event of an action instituted by or in the name of Transgenomic under this
Agreement or to enforce or interpret any of the terms of this Agreement,
Indemnitee shall be entitled to be paid all court costs and expenses, including
attorneys' fees incurred by Indemnitee in defense of such action (including with
respect to Indemnitee's counterclaims and cross-claims made in such action),
unless as a part of such action the court determines that each of Indemnitee's
material defenses to such was made in bad faith or was frivolous.

                  19. NOTICES. All notices, requests, demands and other
communications under this Agreement shall be in writing and shall be deemed duly
given (i) if delivered by hand and receipted for by the party addressee, on the
date of such receipt, or (ii) if mailed by domestic certified or registered mail
with postage prepaid, on the third business day after the date postmarked.
Addresses for notice to either party are as shown on the first page of this
Agreement, or as subsequently modified by written notice. Notice to Transgenomic
shall be directed to the Company at its main office in Omaha or such other
address as Transgenomic shall designate in writing to Indemnitee. Notice to the
Indemnitee shall be directed to the Indemnitee at the address shown on the first
page of this Agreement (or such other address as the Indemnitee shall designate
in writing to Transgenomic).

                  20. CHOICE OF LAW. This Agreement shall be governed by and its
provisions construed in accordance with the laws of Delaware as applied to
contracts between Delaware residents entered into and to be performed entirely
within Delaware.

                  If the foregoing correctly sets forth our understanding, I
would appreciate your executing the enclosed counterpart of this agreement and
returning it to me. Upon your signature this letter agreement shall constitute a
binding agreement, executed under seal.

                                          Very truly yours,

                                          TRANSGENOMIC, INC.

                                          By: /s/ Collin J. D'Silva
                                              ----------------------------------
                                              Collin J. D'Silva

AGREED TO AND ACCEPTED:
INDEMNITEE:

/s/ Gregory J. Duman
- ---------------------------------
Gregory J. Duman




<PAGE>

                                                                   EXHIBIT 10.13


                              AMENDED AND RESTATED
                            REVOLVING LOAN AGREEMENT

         THIS AMENDED AND RESTATED REVOLVING LOAN AGREEMENT, dated March 8,
2000, by and between Transgenomic, Inc., a Delaware corporation ("BORROWER") and
First National Bank of Omaha, a national banking association with principal
business offices in Omaha, Nebraska ("BANK").

                              W I T N E S S E T H:

         Background. Whereas, BANK and Cetac Technologies, Inc. originally
executed a Revolving Loan agreement March 14, 1997. Subsequently, Cetac Holding
Company, Inc. acquired all assets and liabilities of Cetac Technologies, Inc.,
and on July 1, 1997, Cetac Holding Company, Inc. was merged into Transgenomic,
Inc., a Delaware corporation. Whereas, Transgenomic, Inc. is the surviving
corporation and is now known to BANK as the BORROWER.

Subsequently, BANK and BORROWER executed a Revolving Loan Agreement September
17, 1997, which has been amended from time to time (said Agreement together with
all amendments are herein referred to as the "ORIGINAL AGREEMENT"), pursuant to
which BANK agreed to make available to BORROWER a revolving line of credit
("REVOLVING CREDIT FACILITY").

                  Therefore, in consideration of the promises herein contained,
and each intending to be legally bound thereby, the parties agree as follows:

Section I. Definitions as used herein:

          1. "ACCOUNTS" "CHATTEL PAPER", "CONTRACTS", "DOCUMENTS", "EQUIPMENT",
"FIXTURES", "GENERAL INTANGIBLES", "GOODS", "INSTRUMENTS", "INVESTMENT PROPERTY"
and "INVENTORY" shall have the same meaning as is given that term in the Uniform
Commercial Code as presently adopted and in effect in the State of Nebraska.

          2. ACCOUNTING. Accounting terms used and not otherwise defined in this
AGREEMENT have the meanings determined by, and all calculations with respect to
accounting or financial matters unless otherwise provided herein shall be
computed in accordance with, GAAP.

          3. "AFFILIATE" means as to any PERSON, each other PERSON that directly
or indirectly, through one or more intermediaries, controls, or is controlled
by, or under common control with, such PERSON.


                                       1
<PAGE>

          4. "AGREEMENT" means this Agreement, as the same may from time to time
be amended or supplemented.

          5. "BORROWING BASE" means, at any time, the amount computed as Total
Borrowing Base on the BORROWING BASE CERTIFICATE most recently delivered to, and
accepted by, the BANK in accordance with this AGREEMENT, and equal to the lesser
of:

                  A. $5,000,000.00; or

                  B. The aggregate of (i) eighty percent (80%) of ELIGIBLE
         ACCOUNTS of the BORROWER, plus (ii) fifty percent (50%) of the Ending
         Inventory of BORROWER at cost (not to exceed $1,500,000.00). It is
         provided, however, that for purposes of the foregoing computation, no
         more than fifty percent (50%) of ELIGIBLE ACCOUNTS used in the
         foregoing computation may consist of Accounts due from non-United
         States entities. It is further provided, however, no demo Inventory of
         BORROWER located outside of the United States shall be included in such
         computation.

          6. "BORROWING BASE CERTIFICATE" means a fully completed certificate
certified by the chief financial officer of the BORROWER to be correct and
delivered to, and accepted by, the BANK. Attached hereto, marked Exhibit "A" and
by this reference made a part hereof is a form of BORROWING BASE CERTIFICATE,
acceptable to BANK, which shall, effective immediately, be used by the parties.

          7. "COLLATERAL" has the meaning given to such term in Section IV.

          8. "COLLATERAL DOCUMENTS" means the note, financing statements and
other documents required by BANK as set forth herein, together with any real
estate mortgage or deed of trust documents used in this transaction.

          9. "ELIGIBLE ACCOUNT" means, at any time, an Account that conforms and
continues to conform to the following conditions:

                  A. The Account arose from a bona fide outright sale of Goods
         by the BORROWER or from services performed by the BORROWER, and such
         Goods have been shipped to the appropriate account debtors or their
         designees (or the sale has otherwise been consummated), or the services
         have been performed for the appropriate account debtors;

                  B. The Account is due and payable not more than 90 days from
         the date of the invoice therefor;


                                       2
<PAGE>

                  C. If more than ten per cent (10%) of the invoices to a
         particular account debtor are ineligible, then all invoices to such
         account debtor shall become ineligible for borrowing purposes;

                  D. BORROWER has not received any notice of the filing of a
         petition in bankruptcy or insolvency laws by or against, the account
         debtor. Upon the receipt by the BORROWER of any such notice, it will
         immediately give the BANK written advice thereof;

                  E. The account debtor is not a subsidiary or other AFFILIATE
         of the BORROWER; and

                  F. The BANK has not deemed such account ineligible because of
         uncertainty about the credit worthiness of the account debtor or
         because the BANK otherwise reasonably considers the collateral value
         thereof to the BANK to be impaired or its ability to realize such value
         to be insecure.

In the event of any dispute, under the foregoing criteria, about whether an
Account is or has ceased to be an ELIGIBLE ACCOUNT the decision of the BANK
shall control.

         10. "EVENT OF DEFAULT" has the meaning provided for in Section VII.

         11. "FINANCIAL STATEMENTS" means the balance sheet of the BORROWER as
of December 31, 1999, and 1998, and statements of income, stockholders' equity,
and statement of cash flow, and notes thereto, of the BORROWER for the years or,
as appropriate, month ended on such dates as audited by independent certified
public accountants of recognized standing to present fairly the consolidated
financial position and results of operations of the BORROWER at such dates and
for such periods in accordance with GAAP.

         12. "GAAP" means generally accepted accounting principles applied
consistently as was done in the preparation of the FINANCIAL STATEMENTS with
such changes or modifications hereto as may be approved in writing by the BANK.

         13. "INDEBTEDNESS" means, as to the BORROWER, all items of
indebtedness, obligation or liability, whether matured or unmatured, liquidated
or unliquidated, direct or contingent, joint or several.

         14. "LOAN TERMINATION DATE" means the earliest to occur of the
following: (i) July 31, 2000, (ii) the date the obligations are accelerated
pursuant to this AGREEMENT, and (iii) the date BANK receives (a) notice in




                                       3
<PAGE>

writing from BORROWER of BORROWER's election to terminate this AGREEMENT and (b)
indefeasible payment in full of the OBLIGATIONS, or such other date as may later
be agreed to by BANK and BORROWER in a written amendment to this AGREEMENT.

         15. "OBLIGATIONS" means the obligation of the BORROWER:

                  A. To pay the principal of, and interest on, any promissory
         note in accordance with the terms thereof and to satisfy all of its
         other liabilities to the BANK, whether hereunder or otherwise, whether
         now existing or hereafter incurred, matured or unmatured, direct or
         contingent, joint or several, including any extensions, modifications,
         renewals thereof, and substitutions therefor and including, but not
         limited to, any obligations under letter of credit agreements;

                  B. To repay to the BANK all amounts advanced by the BANK
         hereunder or otherwise on behalf of the BORROWER, including, but
         without limitation, advances for principal or interest payments to
         prior secured parties, mortgagees, or licensors, or taxes, levies,
         insurance, rent, or repairs to, or maintenance or storage of, any of
         the COLLATERAL; and

                  C. To reimburse the BANK, on demand, for all of the BANK's
         expenses and costs, including the reasonable fees and expenses of its
         counsel, in connection with the preparation, administration, amendment,
         modification, or enforcement of this AGREEMENT and the documents
         required hereunder, including, without limitation, any proceeding
         brought or threatened, to enforce payment of any of the OBLIGATIONS
         referred to in the foregoing Paragraphs A and B.

         16. "PERMITTED LIENS" means:

                  A. Liens for taxes, assessments, or similar charges, incurred
         in the ordinary course of business that are not yet delinquent;

                  B. Pledges or deposits made in the ordinary course of business
         to secure payment of workers' compensation, or to participate in any
         fund in connection with workers' compensation, unemployment insurance,
         old-age pensions or other social security programs;

                  C. Liens of mechanics, materialmen, warehousemen, carriers, or
         other like liens, securing obligations incurred in the ordinary course
         of business that are not yet due and payable;

                  D. Liens in favor of the BANK; and


                                       4
<PAGE>

                  E. Liens in favor of Security National Bank, Omaha, Nebraska,
         as evidenced by Nebraska Sec. of State financing statement #709241
         covering all equipment and fixtures of BORROWER, to the extent that
         such lien encumbers only those items as described on the attachment
         filed with the financing statement #709241.

         17. "PERSON" means any individual, corporation, partnership,
association, joint-stock company, trust, unincorporated organization, joint
venture, court, or government or political subdivision or agency thereof.

         18. "SUBORDINATED NOTES" means the BORROWER's promissory notes dated
March 24, 1999, in the original aggregate principal amount of $12,000,000,
denominated as "Convertible Notes".

Section II.  REVOLVING CREDIT FACILITY.

         1. REVOLVING CREDIT FACILITY. BANK agrees to lend $5,000,000.00 to
BORROWER pursuant to this facility. BANK will credit proceeds of this REVOLVING
CREDIT FACILITY to BORROWER's deposit account with the BANK, bearing number
11225078.

                  A. Subject to the terms hereof the BANK will lend the
         BORROWER, from time to time until the LOAN TERMINATION DATE such sums
         in integral multiples of $1,000 as the BORROWER may request by
         reasonable same day notice to BANK, received by the BANK not later than
         11:00 A.M. of such day, but which shall not exceed in the aggregate
         principal amount at any one time outstanding, $5,000,000.00 (the "LOAN
         COMMITMENT"). The BORROWER may borrow, repay without penalty or premium
         and reborrow hereunder, from the date of this AGREEMENT until the LOAN
         TERMINATION DATE, either the full amount of the LOAN COMMITMENT or any
         lesser sum. It is the intention of the parties that the outstanding
         principal amount of the REVOLVING CREDIT FACILITY shall at no time
         exceed the amount of the then existing BORROWING BASE and if, at any
         time, an excess shall for any reasons exist, the full amount of such
         excess, together with accrued and unpaid interest thereon as herein
         provided, shall be immediately due and payable in full.

                  B. THE NOTE. The LOAN COMMITMENT shall be evidenced by a
         promissory note ("NOTE") having stated maturity on the LOAN TERMINATION
         DATE, in the form attached hereto as Exhibit B. The NOTE shall specify
         the manner of principal and interest payments and rate of interest
         accrual.


                                       5
<PAGE>

         2. PAYMENT TO THE BANK AND COLLECTIONS.

                  A. All outstanding principal and unrepaid interest shall be
         due and payable on LOAN TERMINATION DATE, unless earlier paid or due as
         the result of acceleration.

                  B. COLLECTION OF ACCOUNTS

                           1. BANK shall have the rights at any time or times
                  hereafter all the rights of a secured creditor holding a
                  valid, and indefeasibly perfected security interest in
                  accounts pursuant to the Nebraska Uniform Commercial Code, as
                  well as the rights conferred by the COLLATERAL DOCUMENTS.

                           2. BORROWER hereby authorizes BANK to endorse, in the
                  name BORROWER, any item, howsoever received by BANK
                  representing payment on or other proceeds of any of the
                  COLLATERAL.

                           3. For purposes of determining the amount of the
                  OBLIGATIONS, including, without limitation, the computations
                  of interest which may from time to time be owing by BORROWER
                  to BANK, the receipt of any check or other item of payment by
                  BANK shall not be treated as a payment on account of the
                  liabilities until such check or other item of payment is
                  actually paid in cash or cash equivalent.

Section III.  CONDITIONS PRECEDENT.

         The obligations of the BANK to make the REVOLVING CREDIT FACILITY is
subject to the following conditions precedent:

          1. DOCUMENTS REQUIRED FOR THE CLOSING. The BORROWER shall have
delivered to the BANK, prior to the initial disbursement of the funds (the
"CLOSING"), the following:

                  A. The COLLATERAL DOCUMENTS, and the FINANCIAL STATEMENTS,
         duly executed by the BORROWER.

                  B. A copy, certified as of the date of the CLOSING, of the
         by-laws of the BORROWER.

                  C. A copy of all amendments to the articles of incorporation
         subsequent to June 27, 1997, certified as of the most recent date
         practicable by the Secretary of State of Delaware, together with a



                                       6
<PAGE>

         certificate (dated the date of CLOSING) of the corporate secretary of
         the BORROWER to the effect that these are all the amendments to such
         articles of incorporation, together with a certificate of good
         standing.

                  D. A certificate, dated the date of the CLOSING, signed by the
         president or a vice president of the BORROWER and to the effect that:

                           1. The representations and warranties set forth in
                  Section V.1. are true as of the date of the CLOSING; and

                           2. No EVENT OF DEFAULT hereunder, and no event which,
                  with the giving of notice or passage of time or both, would
                  become such an EVENT OF DEFAULT, has occurred as of such date;

                  E. A duly executed BORROWING BASE CERTIFICATE as of a date not
         more than one (1) day prior to the CLOSING, acceptable to the BANK.

                  F. An assignment of the General American life insurance policy
         number 3949515, in form satisfactory to BANK, which policy insures the
         life of Colin D'Silva in an amount no less than $4,000,000.

         2. CERTAIN EVENTS. At the time of, and as a condition to, the CLOSING
and each disbursement of any part of the REVOLVING LOAN to be made by the BANK
at or subsequent to the CLOSING:

                  A. No EVENT OF DEFAULT shall have occurred and be continuing,
         and no event shall have occurred and be continuing that, with the
         giving of notice or passage of time or both, would be an EVENT OF
         DEFAULT;

                  B. No material adverse change shall have occurred in the
         business prospects, financial condition, or results of operations of
         the BORROWER since the dates of the FINANCIAL STATEMENTS; and

                  C. All of the COLLATERAL DOCUMENTS shall have remained in full
         force and effect.

Section IV.  COLLATERAL SECURITY.

         1. BORROWER has executed a security agreement, granting a security
interest in and to certain property ("COLLATERAL") to BANK. Such separate
security agreement is a COLLATERAL DOCUMENT.


                                       7
<PAGE>

Section V.   REPRESENTATIONS AND WARRANTIES.

         1. ORIGINAL. To induce the BANK to enter into this AGREEMENT, the
BORROWER represents and warrants to the BANK as follows:

                  A. The BORROWER has no subsidiaries, except for Transgenomic
         Ltd. in the United Kingdom, CETAC-Scientific Instruments B.V. in the
         Netherlands, and Transgenomic St. Thomas Inc. in the USVI (a foreign
         sales corporation) (collectively the "SUBSIDIARIES");

                  B. The BORROWER is not in default with respect to any of its
         existing INDEBTEDNESS, and the making and performance of this agreement
         and the COLLATERAL DOCUMENTS will not (immediately or with the passage
         of time, the giving of notice, or both):

                           1. Violate the articles of incorporation or by-laws
                  of the BORROWER, or violate any laws or result in a default
                  under any contract, agreement, or instrument to which the
                  BORROWER is a party or by which the BORROWER or its property
                  is bound; or

                           2. Result in the creation or imposition of any
                  security interest in, or lien or encumbrance upon, any of the
                  assets of the BORROWER except in favor of the BANK;

                  C. This agreement and the COLLATERAL DOCUMENTS are, or when
         delivered will be, valid, binding, and enforceable in accordance with
         their respective terms;

                  D. There is no pending order, notice, claim, litigation,
         proceeding, or litigation against or affecting the BORROWER, whether or
         not covered by insurance, that would materially or adversely affect the
         financial condition or business prospects of the BORROWER if adversely
         determined;

                  E. The FINANCIAL STATEMENTS, including any schedules and notes
         pertaining thereto, have been prepared in accordance with GAAP, and
         fully and fairly present the financial condition of the BORROWER at the
         dates thereof and the results of operations for the periods covered
         thereby, and there have been no material adverse changes in the
         consolidated financial condition or business of the BORROWER from
         December 31, 1999, to the date hereof;

                  F. As of the date hereof the BORROWER has no material
         INDEBTEDNESS of any nature, including but without limitation,
         liabilities for taxes and any interest or penalties relating thereto
         except to



                                       8
<PAGE>

         the extent reflected (in a footnote or otherwise) in the FINANCIAL
         STATEMENT or as disclosed in, or permitted by, this agreement; and the
         BORROWER does not know or have reasonable ground to know of any basis
         for the assertion against it of any such INDEBTEDNESS as of the date of
         the CLOSING;

                  G. No representation or warranty by or with respect to the
         BORROWER contained herein or in any certificate or other document
         furnished by the BORROWER pursuant hereto contains any untrue statement
         of a material fact or omits to state a material fact necessary to make
         such representation or warranty not misleading in light of the
         circumstances under which it was made;

                  H. Any federal tax returns for all years of operation,
         including the last tax year for BORROWER have been, or will be, filed
         by October 15, 2000, with the Internal Revenue Service and have not
         been challenged;

                  I. Any Employee Pension Benefit Plans, as defined in the
         Employee Retirement Income Security Act of 1974, as amended ("ERISA"),
         of the BORROWER meet, as of the date hereof, the minimum funding
         standards of 29 U.S.C. Sec. 1082 (Sec. 302 of ERISA), and no Reportable
         Event or Prohibited Transaction as defined in ERISA, has occurred with
         respect to any Employee Benefit Plans, as defined in ERISA, of the
         BORROWER;

                  J. BORROWER warrants (and this shall be a continuing warranty
         which shall survive until all the OBLIGATIONS of BORROWER to BANK have
         been fully satisfied) that it is in compliance with all federal, state
         and local environmental laws and regulations and has obtained all
         environmental permits necessary or appropriate to the conduct of its
         business. There is not pending nor, to the best of the BORROWER's
         knowledge after due inquiry, are there any threatened environmental
         enforcement actions, suits or proceedings before any court, tribunal or
         administrative body or official. Responsible officers and agents of the
         BORROWER have made an extensive investigation and have determined that
         the BORROWER has not, nor has any former owner of real property
         occupied by BORROWER stored, used or disposed of any toxic or hazardous
         substance on its properties or transported any such substance to or
         from its properties in violation of any presently existing or
         previously existing laws, regulations or policies. The BORROWER will
         store, use or dispose of such substances on its properties in
         accordance with presently existing or previously existing laws,
         regulations or policies.


                                       9
<PAGE>

         2. SURVIVAL. All of the representations and warranties set forth in
Section V.1. shall survive until all OBLIGATIONS are satisfied in full and there
remain no outstanding commitments hereunder.

Section VI. COVENANTS OF THE BORROWER.

         1. AFFIRMATIVE COVENANTS. The BORROWER does hereby covenant and agree
with the BANK that, so long as any of the OBLIGATIONS remain unsatisfied or any
commitments hereunder remain outstanding, it will comply at all times with the
following covenants:

                  A. The BORROWER will furnish the BANK:

                           1. Within thirty (30) days after the close of each
                  monthly accounting period in each fiscal year an income
                  statement and balance sheet of the BORROWER for such month in
                  reasonable detail, subject to normal year-end audit
                  adjustments and certified by the BORROWER's president or
                  principal financial officer to have been prepared in
                  accordance with GAAP;

                           2. Within thirty (30) days after the end of each
                  calendar month, in such form and detail as shall be
                  satisfactory to the BANK, an aging, as of the end of such
                  month, of (a) the then ELIGIBLE ACCOUNTS, and (b) all other
                  Accounts of the BORROWER, certified by the president or chief
                  financial officer of the BORROWER to be complete and correct;

                           3. Each month (and at any additional time in the
                  discretion of the BANK or if any material deterioration in the
                  BORROWING BASE would be disclosed thereby) a BORROWING BASE
                  CERTIFICATE as of the end of such period. Each BORROWING BASE
                  CERTIFICATE shall be effective only as accepted by the BANK
                  (and with such revisions, if any, as the BANK may require as a
                  condition to such acceptance);

                           4. Within ninety (90) days after the close of each
                  fiscal year, income statements, balance sheets and statement
                  of cash flow of the BORROWER, for such fiscal year. These
                  reports are to be audited by independent certified public
                  accountant of recognized standing to present fairly the
                  consolidated financial position and results of operations of
                  the BORROWER in accordance with GAAP; and accompanied by such
                  accountants' opinion thereof that such documents have been
                  audited in compliance with the American Institute of Certified
                  Public Accountants Statements of Auditing Standards in effect
                  as of the



                                       10
<PAGE>

                  execution hereof; such accountants' opinion and certification
                  shall be directed to the BANK, providing that the client
                  representation of the accountants extends to BANK;

                  B. The BORROWER will maintain:

                           1. A BORROWING BASE such that the amount of the
                  BORROWER'S outstanding REVOLVING CREDIT FACILITY will not, at
                  any time, exceed its BORROWING BASE;

                           2. A minimum Tangible Net Worth of $6,000,000 as of
                  December 31, 1999, and at the end of each subsequent calendar
                  quarter. (For purposes of the calculation of this ratio,
                  SUBORDINATED NOTES should be added to Tangible Net Worth);

                           3. A minimum Net Working Capital of $3,000,000 as of
                  December 31, 1999, and at the end of each subsequent calendar
                  quarter;

                           4. A maximum ratio of "Total Liabilities/Tangible Net
                  Worth" of 1.5:1.0, as of December 31, 1999, and at the end of
                  each subsequent calendar quarter. (For purposes of the
                  calculation of this ratio, SUBORDINATED NOTES should be
                  deducted from Total Liabilities and added to Tangible Net
                  Worth).

                  For purposes of this agreement, Current Assets and Current
         Liabilities, mean, at any time, all assets or liabilities,
         respectively, that should, in accordance with GAAP, be classified as
         current assets or current liabilities, respectively, or be classified
         as a liability on a balance sheet of BORROWER. Net Working Capital
         means, at any time, the amount by which Current Assets exceed Current
         Liabilities. Total Liabilities mean all liabilities, which should, in
         accordance with GAAP, be classified as a liability. Tangible Net Worth
         means, at any time, Stockholders' Equity (the par value of outstanding
         capital stock, plus capital surplus, plus retained earnings, plus the
         principal balance of the SUBORDINATED NOTES, plus any amount reflecting
         cost of patents and proprietary software) less the sum of:

                           a. Any surplus resulting from any write up of assets
                  subsequent to December 31, 1998;

                           b. Goodwill, including any amounts, however
                  designated on a balance sheet of the BORROWER, representing
                  the excess of the purchase price paid for assets or stock
                  acquired over the value assigned thereto on the books of the
                  BORROWER;


                                       11
<PAGE>

                           c. Any amount at which shares of capital stock of the
                  BORROWER appear as an asset on the BORROWER'S balance sheet;

                           d. Loans and advances to stockholders, directors,
                  officers, or AFFILIATES;

                           e. Deferred taxes and deferred expenses;

                           f. Any amount reflecting value of trademarks, trade
                  names, and copyrights; and

                           g. Any other amount in respect of an intangible that
                  should be classified as an asset on a balance sheet of the
                  BORROWER in accordance with GAAP except for the cost of
                  patents and proprietary software, which are included in
                  Tangible Net Worth as indicated above.

                  C. The BORROWER will take all necessary steps to preserve its
         corporate existence and franchises and comply with all present and
         future laws applicable to it in the operation of its business, and all
         material agreements to which it is subject.

                  D. The BORROWER will give immediate notice to the BANK of (1)
         any litigation or proceeding in which it is a party if an adverse
         decision therein would require it to pay more than $10,000.00 or
         deliver assets the value of which exceeds such sum (whether or not the
         claim is considered to be covered by insurance); and (2) the
         institution of any other suit or proceeding involving it that might
         materially and adversely affect its operations, financial condition,
         property, or business prospects.

                  E. The BORROWER will pay when due all of its INDEBTEDNESS due
         third persons except when the amount thereof is being contested in good
         faith by appropriate proceedings and with adequate reserves therefor
         being set aside on its books.

                  F. The BORROWER will notify the BANK immediately 1) if it
         becomes aware of the occurrence of any EVENT OF DEFAULT or of any fact,
         condition, or event that only with the giving of notice or passage of
         time or both, could become an EVENT OF DEFAULT; 2) if it becomes aware
         of any material adverse change in the business prospects, financial
         condition (including, without limitation, proceedings in bankruptcy,
         insolvency, or reorganization), or results of operations of the
         BORROWER, or 3) upon the failure of the BORROWER to observe any of



                                       12
<PAGE>

         its respective undertakings hereunder or under the COLLATERAL
         DOCUMENTS.

                  G. The BORROWER will (1) fund any of its Employee Pension
         Benefit Plans in accordance with no less than the minimum funding
         standards of 29 U.S.C. Sec. 1082 (Section 302 of ERISA); (2) furnish
         the BANK, promptly after the filing of the same, with copies of any
         reports or other statements filed with the United States Department of
         Labor or the Internal Revenue Service with respect to any such Plan;
         and (3) promptly advise the BANK of the occurrence of any Reportable
         Event or Prohibited Transaction with respect to any Employee Benefit
         Plan.

                  H. BORROWER shall retain the services of Collin D'Silva as its
         Chairman of the Board and CEO.

                  I. The BORROWER shall furnish BANK an opinion of counsel, in
         form and substance satisfactory to BANK, opining that the execution
         and delivery of the AGREEMENT, as hereby amended, does not conflict
         with any provisions of the SUBORDINATED NOTES, the charter or bylaws
         of the BORROWER, or of any applicable LAWS, or any other agreement
         binding the BORROWER or its property of which, after reasonable
         inquiry, such counsel has knowledge.

                  J. BORROWER has negotiated a sale of its scientific instrument
         business to a former officer of BORROWER, or his nominee. The proceeds
         of that sale will include no less than $5,000,000 in cash paid to
         BORROWER. BORROWER agrees that the said proceeds will be either
         utilized as working capital by BORROWER; paid to BANK to reduce the
         principal balance of the OBLIGATIONS; or paid to reduce the loans due
         to Security National Bank in an amount no greater than that listed on
         the draft of the Audited Financial Statement dated 12-31-1999 plus
         accrued interest. BORROWER agrees that no portion of the said proceeds
         shall be paid on account of any other security interest or lien on
         assets of BORROWER other than the OBLIGATIONS, nor paid to any
         Stockholder of BORROWER or holder of any debentures issued by
         BORROWER, without BANK'S written approval.

         2. NEGATIVE COVENANTS. The BORROWER does hereby covenant and agree with
the BANK that, so long as any of the OBLIGATIONS remain unsatisfied or any
commitments hereunder remain outstanding, it will comply at all times with the
following negative covenants, unless the BANK shall otherwise have agreed in
writing, which agreement will not be unreasonably withheld:

                  A. The BORROWER shall not change its name, enter into any
         merger, consolidation, reorganization or recapitalization, or
         reclassify its capital stock;


                                       13
<PAGE>

                  B. BORROWER will not mortgage, pledge, grant, or permit to
         exist a security interest in, or a lien upon, any of its assets of any
         kind, now owned or hereafter acquired, except for liens in favor of
         BANK, or PERMITTED LIENS, or liens subordinate and junior to the lien
         of the BANK;

                  C. BORROWER will not become liable, directly or indirectly, as
         Guarantor or otherwise for any OBLIGATION of any other person;

                  D. BORROWER will not declare or pay any dividends, or make any
         other payment or distribution on account of its capital stock; nor make
         any assignment or transfer of Accounts, or, other than in the ordinary
         course of business, of Inventory;

                  E. BORROWER will form no subsidiary, make no investment in
         (including any assignment of Inventory or other property), or make any
         loan in the nature of an investment to, any person;

                  F. BORROWER will not make any loan or advance to any officer,
         shareholder, director, or employee of the BORROWER, except for business
         travel and similar temporary advances in the ordinary course of
         business;

                  G. BORROWER will not redeem, purchase, or retire any of its
         capital stock, or purchase or retire for any consideration, any
         warrant, right or option pertaining thereto, or permit any redemption,
         retirement, or other acquisition by BORROWER of the ownership of the
         outstanding capital stock of the BORROWER;

                  H. BORROWER shall not furnish the BANK any certificate or
         other document that will contain any untrue statement of material fact
         or that will omit to state a material fact necessary to make it not
         misleading in light of the circumstances under which it was furnished;
         and

                  I. BORROWER will not directly or indirectly apply any part of
         the proceeds of the OBLIGATIONS to the purchasing or carrying of any
         "margin stock" within the meaning of Regulation U of the Board of
         Governors of the Federal Reserve System, or any regulations,
         interpretations, or rulings thereunder.

                  J. BORROWER will not make any prepayments of principal or
         interest on the SUBORDINATED NOTES, and in the EVENT OF DEFAULT under
         the AGREEMENT, the BORROWER will not make any



                                       14
<PAGE>

         further payments of principal or interest on the SUBORDINATED NOTES
         without prior consent of the BANK. BORROWER will not take any other
         actions that would result in these SUBORDINATED NOTES being or becoming
         superior in any manner to the OBLIGATIONS. BORROWER agrees not to give
         SUBORDINATED NOTES any security interest in the assets of the BORROWER
         without the permission of BANK.

Section VII.  DEFAULT.

         1. EVENTS OF DEFAULT. The occurrence of any one or more of the
following events shall constitute an EVENT OF DEFAULT hereunder:

                  A. The BORROWER shall fail to perform any covenant, promise,
         or payment obligation made in this AGREEMENT or any COLLATERAL
         DOCUMENTS;

                  B. Any financial statement, representation, warranty, or
         certificate made or furnished by or with respect to the BORROWER to the
         BANK in connection with this AGREEMENT, or as an inducement to the BANK
         to enter into this AGREEMENT, or in any separate statement or document
         to be delivered to the BANK hereunder, shall be materially false,
         incorrect, or incomplete when made.

         2. ACCELERATION. At the option of the BANK upon the occurrence of any
EVENT OF DEFAULT, all OBLIGATIONS, whether hereunder or otherwise, shall
immediately become due and payable.

         3. REMEDIES. After any acceleration, as provided for in Section VII.
2., the BANK shall have, in addition to the rights and remedies given it by this
AGREEMENT and the COLLATERAL DOCUMENTS, all those allowed by all applicable
laws, including, but without limitation, the Uniform Commercial Code as enacted
in any jurisdiction in which any COLLATERAL may be located. The rights of the
BANK under this Section VII.3. are in addition to the other rights and remedies
(including, without limitation, other rights of set-off) which the BANK may
have.

Section VIII.  MISCELLANEOUS.

         1. CONSTRUCTION. Nothing herein contained shall prevent the BANK from
enforcing any or all other guaranty, pledge or security agreements, notes,
mortgages, deeds of trust, other evidences of liability, or other COLLATERAL
DOCUMENTS in accordance with their respective terms.

         2. ENFORCEMENT AND WAIVER BY THE BANK. The BANK shall have the right at
all times to enforce the provisions of this agreement and the



                                       15
<PAGE>

COLLATERAL DOCUMENTS in strict accordance with the terms hereof and thereof,
notwithstanding any conduct or custom on the part of the BANK in refraining from
so doing at any time or times to enforce its rights under such provisions,
strictly in accordance with the same, shall not be construed as having created a
custom in any way or manner contrary to specific provisions of this AGREEMENT or
as having in any way or manner modified or waived the same. All rights and
remedies of the BANK are cumulative and concurrent and the exercise of one right
or remedy shall not be deemed a waiver or release of any other right or remedy.

         3. RENEWAL. On the existing LOAN TERMINATION DATE, all of the
OBLIGATIONS become due, and the BANK's commitment to lend shall terminate.
BORROWER may request an amendment of the LOAN TERMINATION DATE and a renewal, in
some form, of the commitment. BANK agrees to consider such request when made,
using as a basis for its decision all of the FINANCIAL STATEMENTS furnished by
BORROWER, together with any other information available to BANK. BANK may make
such renewal or amendment if, in BANK's sole discretion, such renewal or
amendment is warranted in the exercise of sound banking practices.

         4. EXPENSE OF THE BANK. The BORROWER will, on demand, reimburse the
BANK for all expenses, including the reasonable fees and expenses of legal
counsel for the BANK, incurred by the BANK in connection with the preparation,
administration, amendment, modification, or enforcement of this AGREEMENT, the
COLLATERAL DOCUMENTS, and the collection or attempted collection of the
OBLIGATIONS.

         5. NOTICES. Any notice or consents required or permitted by this
AGREEMENT shall be in writing and shall be deemed delivered if delivered in
person or if sent by certified mail, postage prepaid, return receipt requested,
or telegraph, as follows, unless such address is changed by written notice
hereunder:

            A. If to the BORROWER:          Transgenomic, Inc.
                                            5600 South 42nd Street
                                            Omaha, Nebraska 68107
                                            Attn:  Collin D'Silva

            B. If to the BANK:              First National Bank of Omaha
                                            One First National Center
                                            Omaha, Nebraska 68102
                                            ATTN: Mark McMillan

         6. WAIVER AND RELEASE BY THE BORROWER. To the maximum extent permitted
by applicable laws, the BORROWER:


                                       16
<PAGE>

                  A. Waives notice of acceleration and of intention to
         accelerate; and notice and opportunity to be heard, after acceleration
         in the manner provided in Section VII, before exercise by the BANK of
         the remedies of self-help, set-off, or of other summary procedures
         permitted by any applicable laws or by any agreement with the BORROWER,
         and, except where required hereby or by any applicable law, notice of
         any other action taken by the BANK; and

                  B. Releases the BANK and its officers, attorneys, agents, and
         employees from all claims for loss or damage caused by any act or
         omission on the part of any of them except willful misconduct or gross
         negligence.

         7. APPLICABLE LAW. This AGREEMENT is entered into and performable in
Omaha, Douglas County, Nebraska, and shall be subject to and construed and
enforced in accordance with the laws of the State of Nebraska.

         8. BINDING EFFECT, ASSIGNMENT, AND ENTIRE AGREEMENT. This AGREEMENT
shall inure to the benefit of, and shall be binding upon, the respective
successors and permitted assigns of the parties hereto. The BORROWER has no
right to assign any of its rights or OBLIGATIONS hereunder without the prior
written consent of the BANK. This AGREEMENT, including the Exhibits hereto, all
of which are hereby incorporated herein by reference, and the documents executed
and delivered pursuant hereto, constitute the entire agreement between the
parties and may be amended only by a writing signed on behalf of each party.

         9. SEVERABILITY. If any provision of this AGREEMENT shall be held
invalid under any applicable law, such invalidity shall not affect any other
provision of this AGREEMENT that can be given effect without the invalid
provision, and, to this end, the provisions hereof are severable.

         IN WITNESS WHEREOF, the parties hereto have duly executed this
AGREEMENT as of the day and year first above written.

                                               TRANSGENOMIC, INC.

                                               By: /s/ Collin J. D'Silva
                                                   -------------------------
                                               Title: Chief Executive Officer
                                                      ----------------------

                                               FIRST NATIONAL BANK OF OMAHA

                                               By: /s/ Mark McMillan
                                                   -------------------------
                                               Title: Second Vice President
                                                      ----------------------


                                       17
<PAGE>

Exhibit A - Borrowing Base Certificate
Exhibit B - Promissory Note



                                       18
<PAGE>


                                    EXHIBIT A



                                       19
<PAGE>

                                    EXHIBIT B

                                 PROMISSORY NOTE

[LOGO]

                               Transgenomic, Inc.
                                5600 So. 42nd St.
                                 Omaha, NE 68107

<TABLE>

<S>                  <C>              <C>           <C>             <C>             <C>
Principal Amount     Interest Rate    Note Date     Maturity Date   Obligor #       Note #
$5,000,000.00        Variable         07/31/99      07/31/00        2000046172      1
                     NAT Base



</TABLE>

Maker promises to pay to the order of First National Bank of Omaha ("Bank") at
any of its offices, the principal sum hereof, which shall be: (Revolving) the
lesser of FIVE MILLION AND NO/100 Dollars or so much thereof as may have been
advanced by Bank. The Maker may borrow, repay without penalty, and reborrow from
Note Date until Maturity Date, either the full amount of this loan or any lesser
sum.

Interest shall accrue on the outstanding principal amount from and including the
Note Date above to the Maturity Date at the rate of: The rate in effect from
time to time and designated by Bank as its National Base Rate ("Base Rate").

Interest shall be computed on the basis of actual days elapsed and a year of 360
days. The unpaid principal and interest due on this Note at maturity (whether
the Note matures by demand, acceleration, lapse of time or otherwise) shall bear
interest at the lesser of 6% per annum above the interest rate stated above, or
the highest rate allowed by law.

Principal and interest shall be paid as follows: Principal due on Maturity Date,
interest due MONTHLY beginning AUGUST 31, 1999 and on the same day of each MONTH
thereafter.

Related Documents: Maker has signed the following documents in connection with
this Note: Security Agreement(s) dated 09/17/97 covering all business assets.

Assignment(s) of Collateral dated July 31, 1999 covering life insurance policy.

Loan Agreement dated 09/17/97 and all amendments thereof.

A credit agreement must be in writing to be enforceable under Nebraska law. To
protect you and us from any misunderstandings or disappointments, any contract,
promise, undertaking, or offer to forebear repayment of money or to make any
other financial accommodation in connection with this loan of money or grant or
extension of credit, or any amendment of, cancellation of, waiver of, or
substitution for any or all of the terms or provisions of any instrument or
document executed in connection with this loan of money or grant or extension of
credit, must be writing to be effective.

Witnessed By:               Transgenomic, Inc.

/s/ Mark McMillan           By:  /s/ Stephen F. Dwyer           Title:  V.C.
- ---------------------            ------------------------             ---------


                                       20
<PAGE>


                              TERMS AND CONDITIONS

1.       Maker shall reimburse Bank for all expenses incurred in protecting or
         enforcing its rights. Maker's liability under its Obligations ("all
         Maker's existing and future obligations of whatever nature and whenever
         incurred to Bank") shall not be affected by any of the following:

         -        Acceptance or retention by Bank of other property or interests
                  as security for the Obligations, or for the liability of any
                  person other than a Maker with respect to the Obligations;

         -        Any release, extension, renewal, modification or compromise of
                  any of the Obligations or the liability of any obligor
                  thereon; or

         -        Failure by Bank to resort to other security or any person
                  liable for the Obligations.

         Each maker specifically consents to multiple renewals or extensions of
         the Obligations. This Note shall be deemed extended through the date of
         any advance made by Bank after the original maturity hereof; and any
         such advance shall constitute principal due under this Note.

2.       REPRESENTATION, WARRANTIES AND COVENANTS. Each Maker represents,
         warrants and covenants as follows:
         This Note, security agreement, deed of trust, mortgage, or other lien
         documents(s), if any, securing the Note have been duly authorized,
         executed and delivered by the Maker and constitute legal, valid and
         binding Obligations of Maker.
         This Note evidences a loan for business or agricultural purposes.
         Maker will provide business reports and with such frequency as Bank
         shall request; and
         Maker agrees to pay all costs of collection in connection with this
         Note, including reasonable attorneys' fees and legal expenses.

3.       DEFAULTS AND REMEDIES. Upon the occurrence of one of more of the
         following events of default:

         -        Maker fails to pay when due any of the Obligations, or to
                  perform or rectify breach of, any warranty or other
                  undertaking by Maker in this Note or the other Obligations; or
                  breaches any other covenant or condition described in any
                  other document;

         -        Any Maker, endorser, surety, or guarantor of any of the
                  Obligations dies, ceases to exist, makes an assignment for the
                  benefit of creditors, becomes insolvent or the subject of
                  bankruptcy or insolvency proceedings;

         -        Any representation made to induce Bank to extend credit under
                  this Note or otherwise is false in any material respect when
                  made;

         -        A material adverse change, in the opinion of Bank, occurs in
                  the financial or business condition of any Maker or of any
                  endorser, surety or guarantor of this Note;

         -        The entry of a judgment against any Maker;

         -        Filling of any lien against any Maker;

         -        The taking possession of any substantial part of the property
                  of any Maker at the instance of any governmental authority;

         -        The dissolution, merger, consolidation, or reorganization of
                  any Maker, or other entity liable for this Obligation;

         -        Any other event occurs which causes Bank in good faith to deem
                  itself insecure;

         then in such event, all of the Obligations shall, at the option of Bank
         and without notice or demand, mature and become immediately due and
         payable; and Bank shall have all rights and remedies for default
         provided by the Uniform Commercial Code, and any other applicable law
         and/or the Obligations.

         All costs and expenses incurred by Bank in enforcing its rights under
         this Note or any mortgage or other lien, endorsement, surety agreement,
         guarantee relating thereto are the obligations of Maker and are
         immediately due and payable. Interest shall accrue on such costs and
         expenses from the date of incurrence at the rate specified herein for
         delinquent Note payments. Each Maker, endorser, surety and guarantor
         hereby waives presentment, protest, demand, notice of dishonor, and the
         defense of any statute of limitations.


                                       21
<PAGE>

4.       GENERAL. Without affecting the liability of any Maker, endorser,
         surety, or guarantor, the holder may, without notice, renew or extend
         the time for payment, accept partial payments, release or impair any
         collateral security for the payment of this Note or agree to sue any
         party liable on it.

         Subject to rights afforded by law, Bank may at any time and for any
         reason, charge to or off-set against any amount then on deposit in any
         account (including a savings certificate), whether or not then due, any
         and all debts or liabilities (sole, several, joint, or joint and
         severable, absolute or contingent, due or not due, liquidated or
         unliquidated, secured or unsecured) then owed to Bank by depositor or
         in the case of a multiple-party account, by any party to such
         multiple-party account, and this agreement shall be construed to be the
         consent of depositor and any such party for the Bank to make such
         charge or off-set if consent be required by any person or future law.

         Bank shall not be deemed to have waived any of its rights upon or under
         this Note, or under any mortgage or other lien, endorsement, surety
         agreement, or guarantee unless such waivers be in writing and signed by
         Bank. No delay or omission on the part of Bank in exercising any right
         shall operate as a waiver of such right or any other right. A waiver on
         any one occasion shall note be construed as a bar to or waiver of any
         right on any future occasion. All rights and remedies of Bank on
         liabilities or the collateral whether evidenced hereby or by any other
         instrument or papers shall be cumulative and may be exercised
         singularly or concurrently.

         Maker, if more than one, shall be jointly and severally liable
         hereunder and all provisions hereof regarding the liabilities or
         security of Maker shall apply to any liability or any security of any
         or all of them. This agreement shall be binding upon the heirs,
         executors, administrators, assigns or successors of Maker; shall
         constitute a continuing agreement, applying to all future as well as
         existing transaction, whether or not of the character contemplated at
         the date of this Note, and if all transactions between Bank and Maker
         shall be at any time closed, shall be equally applicable to any new
         transactions thereafter; shall benefit Bank, its successors, and
         assigns; and shall so continue in force not withstanding any change in
         any partnership party hereto, whether such change occurs through death,
         retirement or otherwise.

         If any party of this Note is a married person, such person or persons
         hereby separately charges his or her separate estate, including both
         that now owned and that hereafter acquired, with the payment of this
         Note.

         This Note shall be construed according to the laws of the State of
         Nebraska. Unless the content otherwise requires, all terms used herein
         which are defined the Uniform Commercial Code shall have the meanings
         therein stated.

         Any provision of this Note which is prohibited or unenforceable in any
         jurisdiction shall, as to such jurisdiction, be ineffective to the
         extent of such prohibition or unenforceability without invalidating the
         remaining provisions hereof or affecting the validity or enforceability
         of such provision in any other jurisdiction.



                                       22


<PAGE>

                                                                   EXHIBIT 10.14


** Certain confidential portions of this Exhibit were omitted by means of
redacting a portion of the text indicated by two double-stricken through
asterisks "**". This Exhibit has been filed separately with the Secretary of the
Commission without the ** pursuant to the Registrant's Application Requesting
Confidential Treatment under Rule 406 of the Securities Act.

                                LICENSE AGREEMENT

         This agreement, entered into and effective as of the first day of
September, 1994, by and between Sarasep, Inc., a corporation of the state of
Nevada, having a place of business at 1600 Wyatt Drive, Suite 10, Santa Clara,
CA 95054 (hereinafter "LICENSEE"), and a group of inventors consisting of Prof.
Dr. Gunther Bonn, Bahnhof Umgebung Nr. 3, A-6170 Zirl, Austria, Dr. Christian
Huber, Ulmenstrasse 65, A-6064 Rum, Austria, and Dr. Peter Oefner,
Unterbergerstrasse 19a/5, A-6020 Innsbruck, Austria, presently at 1300 Oak Creek
Drive, Apartment 221, Palo Alto, California US 94306-2008, inventors represented
by Prof. Dr. Bonn (hereinafter "LICENSOR"). Prof. Dr. Bonn will be the interface
for all contact between LICENSEE AND LICENSOR unless directed otherwise by Dr.
Bonn.

                                   WITNESSETH:

         WHEREAS, LICENSOR is the owner of polymer technology and is the owner
of patent applications set forth in Schedule A appended to this Agreement
relating to nonporous, chromatographic, polymer resins;

         WHEREAS, LICENSEE wishes to obtain and Licensor is willing to grant a
exclusive, royalty-bearing license under this technology.

         NOW, THEREFORE, the parties intending to be legally bound agree as
follows:

ARTICLE 1 - DEFINITIONS

         1.01 "TECHNOLOGY RIGHTS" shall mean the technology and/or patents
applications or patents issued from said applications listed in Schedule A, or
as later amended by written agreement of the parties.

         1.02 "PRODUCTS" shall mean columns and bulk material listed in Schedule
for the separation and/or solid phase clean-up of DNA, DNA fragments or
oligonucleotides.

         1.03 "NET SALES" shall mean the actual gross amount of the invoices
covering all of LICENSEE's sales of PRODUCTS to customers other than affiliates,
less cash discounts and rebates actually given, duties, returns and free
replacements. NET SALES of PRODUCTS used by LICENSEE or AFFILIATES shall be the
highest price paid during the reporting period by another to LICENSEE or any
AFFILIATE for such PRODUCTS. In the event the NEW SALES price of PRODUCTS sold
cannot be reasonably determined, the NET SALES price shall be the cost of
manufacture plus 300% of the cost of manufacture as determined by normal
accounting practices. In the event of sales or transfer to an AFFILIATE for
eventual sales to an end-user or an intermediary, the royalty shall be paid by
LICENSEE based on the NET SALES by the AFFILIATE to the end-user or
intermediary.

         1.04 "AFFILIATE" shall mean any entity in which at least forty-nine
percent (49%) of the stock normally entitles to vote for the election of
directors is directly or indirectly owned or controlled by LICENSEE.

ARTICLE 2 - GRANT


<PAGE>

         LICENSOR hereby grants to LICENSEE, and LICENSEE hereby accepts,
subject to the terms and conditions set forth in this Agreement, a exclusive
license under the TECHNOLOGY RIGHTS to make use and sell PRODUCTS to LICENSEE's
customers for PRODUCTS purchased from LICENSEE, provided that only to the extent
that LICENSEE has paid royalties due to LICENSOR under this Agreement.

         This Agreement is for columns sold to affiliates, users, distributors
or instrument manufacturers or for bulk media sold to affiliates or directly to
HPLC users for DNA separations. Bulk media shall not be sold to column
manufacturers or instrument manufacturers unless by mutual agreement of LICENSEE
AND LICENSOR.

         This Agreement covers the sale and distribution of nonporous columns or
media for DNA separations as shown in Schedule A. Sale of HPLC instrumentation
employing said columns or shall require a separate agreement to determine the
terms of royalty payment to LICENSOR. Should LICENSOR or its assigns not pursue
sale and distribution of HPLC instrumentation for DNA separations, it is
understood that LICENSOR shall attempt to negotiate agreement or agreements with
one or more instrument manufacturers for the sale and distribution of HPLC
instrumentation DNA separations using the technology as shown in Schedule A. It
is also understood that LICENSOR shall have the right to negotiate an agreement
with an instrument manufacturer, through mutual agreement of LICENSOR AND
LICENSEE.

ARTICLE 3 - MARKING

         LICENSEE shall mark and label product literature or packages for the
PRODUCTS with the following legend:

         This product is subject to one or more US or World patent applications.

         When patent applications have been granted the LICENSEE shall mark and
label product literature or packages for the PRODUCTS with the following legend
where x denotes the patent number.

         The Purchaser is entitled to utilize this product under Patent Number x
for the separation of DNA fragments.

         In addition, all literature, product packages or performance sheets
shall carry relevant citations of the inventors. The list of citations is shown
in Schedule A and shall be updated by mutual agreement of LICENSOR and LICENSEE.

ARTICLE 4 - PAYMENTS AND REPORTS

         4.01 For the rights granted under this Agreement, LICENSEE shall pay to
LICENSOR as licensing fee, ** for every column for the first ** columns sold to
users. LICENSOR shall provide packing material for said columns. The first
material for packing columns shall be available starting January 9, 1995. The
Licensee fee shall be paid quarterly for only those columns that have been
actually sold.

         4.02 For the rights granted under this Agreement, LICENSEE shall pay to
LICENSOR as a royalty ** of NET SALES of columns and bulk media sold beyond the
first ** columns. A minimum royalty payment of ** per year shall be paid on a
quarterly basis. Royalty payments shall be effective starting January 1, 1995,
but amount of royalty payment shall be deducted from licensing fee until the
first ** columns have been sold.


                                       2
<PAGE>

         4.03 LICENSEE shall make written reports to LICENSOR within sixty (60)
days after the end of each calendar quarter during the term of this Agreement.
Each report shall state the net sales of the PRODUCT during the calendar
quarter. The report shall also set forth the manner in which the license fee and
royalty has been computed. The license fee and royalty for PRODUCTS sold during
each calendar quarter shall be due and payable with the report for that quarter.

         4.04 LICENSEE shall maintain sufficiently detailed book and records for
the PRODUCT sold or used by LICENSEE and AFFILIATES to enable LICENSOR to verify
the payments made to LICENSOR by LICENSEE. LICENSEE shall permit an accountant,
appointed by LICENSOR and reasonably acceptable to LICENSEE, to inspect, at
reasonable times and upon reasonable notice, but not to exceed once per year,
the book and records of licensee relating to the sale of PRODUCT. The accountant
shall report to LICENSOR only whether the amounts reported and paid to LICENSOR
by LICENSEE are accurate. In no event, however, shall an examination of
LICENSEE's book be made for a period prior to three (3) years before the date
such audit is requested by LICENSOR. In the event the accountant reports to
LICENSOR that LICENSEE has underpaid the amounts due to LICENSOR by more than
ten percent (10%), then LICENSEE shall bear the costs of such audit.

         4.05 LICENSEE shall pay all reasonable costs for US and Europe patent
costs and shall make reasonable efforts to argue the prosecution of the
application to the appropriate patent examiners. LICENSEE shall have the right
to pursue patent rights in any other country that LICENSEE determines to be
commercially in the best interest of LICENSEE. LICENSEE shall inform LICENSOR of
all steps of prosecution and defense of the patent applications or patents
thereof. Should LICENSEE intend to abandon or assign any application or any part
thereof, LICENSEE will provide the possibility for LICENSOR to acquire said
applications or parts thereof. LICENSOR shall be responsible for the
reassignment costs. LICENSOR will retain a non-exclusive license.

ARTICLE 5 - PATENTS AND TECHNOLOGY

         5.01 LICENSOR shall provide reasonable support to LICENSEE of technical
information and other information to allow LICENSEE to argue the prosecution of
the various patent applications before the patent examiners.

         5.02 LICENSEE shall pay for patents costs as set forth in Article 4
above.

         5.03 LICENSOR has assigned patent rights to LICENSEE in accordance to
document signed prior to US patent application and World PCT patent application
and specific country and Europe applications.

         5.04 LICENSOR AND LICENSEE both agree to keep confidential synthesis or
manufacturing procedures except to the extent required in journal publications
or patent applications. LICENSOR and LICENSEE both agree that synthesis
descriptions in journals or other publications shall be stated in general terms
and not state key manufacturing details.

ARTICLE 6 - TERM AND TERMINATION

         6.01 In the event that LICENSEE is able to obtain European and/or US
patent rights, this Agreement shall remain in effect for twenty (20) years. In
the event that LICENSEE is not able to obtain either European or US patent
rights, this Agreement shall be in effect for five (5) years.


                                       3
<PAGE>

         6.02 LICENSEE may terminate the Agreement and the licenses granted
under this Agreement by giving LICENSOR three (3) months prior written notice of
LICENSEE's intention to terminate.

         6.03 LICENSOR, at it discretion, may terminate the Agreement for one of
the following reasons by giving notice to LICENSEE:

         (1) If there is a proceeding commenced against LICENSEE under any
bankruptcy act or under any present or future law for relief of debtors, or a
receiver or trustee is appointed for LICENSEE or LICENSEE's asset, or an action
or proceeding is commenced to dissolve LICENSEE, or LICENSEE makes an assignment
for the benefit of creditors or ceases to carry on business for any reason; or

         (2) If LICENSEE fails to perform or observe any of the agreements,
provisions, duties or obligations under the Agreement such as the timely
reporting and payment of royalties, and does not remedy the failure within
thirty (30) days after receipt of notice from LICENSOR, provided, however, that
repeated failures by LICENSEE shall constitute an independent basis for LICENSOR
to terminate this Agreement.

         6.04 The termination of the Agreement shall not prejudice any rights or
remedies which shall have accrued to either party prior to the date of such
termination.

         6.05 LICENSOR shall keep confidential all technology manufacturing
processes. Confidentiality shall survive this agreement for a period of ten (10)
years beyond termination of this agreement.

ARTICLE 7 - ASSIGNMENT

         This Agreement and the right granted in this Agreement are personal to
LICENSEE. LICENSEE shall have the right to assign rights of this Agreement
provided that assignee assumes all rights and responsibilities of the Agreement.

ARTICLE 8 - NOTICES

         Any notice required or provided for by the terms of this Agreement
shall be in writing. All notices shall be sent by first class mail, postage
prepaid, to the business address of the party to be given notice. The business
addresses of the parties shall be as follows:

Sarsep, Inc.                                      Prof. Dr. Gunther Bonn
1600 Wyatt Dr., Suite 10                          Bahnhof Umgebung Nr. 3
Santa Clara, CA  95054                            A-6170 Zirl
USA                                               Austria
Attn:    President

Either party may change its business address by notice to the other party.

ARTICLE 9 _- AGREEMENT

         This Agreement is full and complete and replaces Marketing Agreement
dated November 27, 1993.

ARTICLE 10 - MISCELLANEOUS

         10.01 This Agreement shall be construed and the legal relations between
the parties determined in accordance with the laws of California.


                                       4
<PAGE>

         10.02. Neither party shall be deemed to have waived any of its rights
under this Agreement by failure to take any actin to enforce any of its rights
at any particular time.

         10.03 This Agreement is the entire Agreement between the parties and
there are no other terms, obligation, covenants, representation, statements or
conditions, oral or otherwise, of any kind. This Agreement may not be changed,
modified, or amended in whole or in part except by written document signed by
the duly-authorized officers of the parties.

         10.04 The provisions of the Agreement shall be deemed separable. A
holding by a court of competent jurisdiction that any provision of this
Agreement which is not material to the consideration provided by either party is
void or unenforceable shall not affect the validity or enforceability of the
remaining provisions of the Agreement.



                                       5
<PAGE>


         IN WITNESS WHEREOF, the parties have caused this Agreement to be
executed in duplicate to be effective as of September 1, 1994.

SARASEP, INC.                                 LICENSOR

By   /s/ Douglas T. Gjerde                    By  /s/ Gunther Bonn
     ------------------------------               ------------------------------
     Douglas T. Gjerde, President                 Prof. Dr. Gunther Bonn

Date                1-5-95                    Date          6.2.1995
     ------------------------------               ------------------------------

                                              By  /s/ Christian Huber
                                                  ------------------------------
                                                  Dr. Christian Huber

                                              Date  January 6th, 1995
                                                  ------------------------------

                                              By  /s/ Dr. Peter Oefner
                                                  ------------------------------
                                                  Dr. Peter Oefner

                                              Date  January 6th, 1995
                                                  ------------------------------



                                       6
<PAGE>

                                    AGREEMENT

         This Agreement is made and entered into this 14th day of March, 1997.
This Agreement is intended to amend and modify Original Agreement dated
September 1, 1994 by and among Sarsep, Inc., a corporation, herein and therein
referred to as "Licensee" and a group of Inventors consisting of Prof. Dr.
Gunther Bonn, Dr. Christian Huber, and Dr. Peter Oefner. Original Agreement
sates that the inventors are represented by Prof. Dr. Gunther Bonn herein and
therein referred to as "Licensor." Prof. Dr. Bonn will be the interface for
contact between the Licensor and Licensee. All definitions in the original
Agreement are incorporated herein.

         WHEREAS, the Original Agreement among the parties provided in Article 2
that the Licensee with the mutual agreement of the Licensor would have the right
to negotiate an agreement with an equipment manufacturer, and

         WHEREAS, the Licensee wishes to develop and market the equipment to be
used with the DNA Technology Rights and the Products and the Licensor is
agreeable to granting the Licensee this right.

         NOW THEREFORE based upon the mutual covenants and considerations
contained herein, the parties agree as follows:

         1. Licensee shall have the exclusive right to develop and manufacture
the instrumentation necessary to use the DNA Products and the Technology Rights.
The Licensor agrees to work exclusively with the licensee on the method of use
of the products and the Technology rights and the Licensor in this regard agrees
not to disclose method of use, proprietary information or competitive
information to any third party.

         2. Licensor agrees to work diligently with Licensee in the development
and application of instrumentation for the Technology Rights and Products.

         3. The parties further agree that ** will be paid with respect to the
instrumentation but the minimum royalty fee set out in paragraph 4.02 shall be
increased to ** per year payable at the rate of ** per quarter. The parties
understand and agree that the Licensee will form a new corporation which will
acquire the Licensee's interest in the Agreement. The principal purpose of the
new corporation will be to promote and develop DNA separation technology. The
new minimum license fee shall begin on the first quarterly payment date
following the funding of the new corporation with a minimum of One Million Five
Hundred Thousand Dollars ($1,500,000.00) of capital. Licensee shall have 18
months from date of this Agreement to complete funding of the new corporation.
If funding is not completed within 18 months, then this Agreement shall expire
but the Original Agreement shall continue.

         4. The parties understand and agree that the inventors use
instrumentation utilizing said DNA separation technology in the course of
performing their research. The inventors shall have the right to develop,
assemble and use instrumentation for the purpose of performing research and
developing new methods and new instrumentation.

         5. In all other respects, the original Agreement is confirmed and
ratified.


<PAGE>

         IN WITNESS WHEREOF, the parties have caused this Agreement to be
executed to be effective as of February 1, 1997.

SARASEP, INC.                                   LICENSOR

By    /s/ Douglas T. Gjerde                     By  /s/ Gunther Bonn
      ----------------------------                  ---------------------------
      Douglas T. Gjerde, Ph.D. President            Prof. Dr. Gunther Bonn

Date          3-14-97                           Date
      ----------------------------                  ---------------------------

                                                By  /s/ Dr. Peter Oefner
                                                    ---------------------------
                                                    Dr. Peter Oefner

                                                Date    3-29-97
                                                    ---------------------------

                                                By  /s/ Dr. Christian Huber
                                                    ---------------------------
                                                    Dr. Christian Huber

                                                Date  April 7, 1997
                                                    ---------------------------

** Certain confidential portions of this Exhibit were omitted by means of
redacting a portion of the text indicated by two double-stricken through
asterisks "**". This Exhibit has been filed separately with the Secretary of the
Commission without the ** pursuant to the Registrant's Application Requesting
Confidential Treatment under Rule 406 of the Securities Act.



                                       2

<PAGE>

                                                                   EXHIBIT 10.15


** Certain confidential portions of this Exhibit were omitted by means of
redacting a portion of the text indicated by two double-stricken through
asterisks "**". This Exhibit has been filed separately with the Secretary of the
Commission without the ** pursuant to the Registrant's Application Requesting
Confidential Treatment under Rule 406 of the Securities Act.

                                    AGREEMENT

Effective as of August 20, 1997 ("Effective Date"), THE BOARD OF TRUSTEES OF THE
LELAND STANFORD JUNIOR UNIVERSITY, a body having corporate powers under the laws
of the State of California ("STANFORD"), and TRANSGENOMIC, INC., a Delaware
corporation having a principal place of business at 5600 South 42nd Street,
Omaha, Nebraska 68107 ("LICENSEE"), agree as follows:

1.  BACKGROUND

1.1      STANFORD has an assignment of "Detection of DNA Heteroduplices by
         Denaturing High Performance Liquid Chromatography" from the laboratory
         of Dr. Peter Oefner and Dr. Peter Underhill, as described in Stanford
         Docket S95-024, ("Invention(s)") and any Licensed Patent(s), as
         hereinafter defined.

1.2      STANFORD desires to have the Invention(s) perfected and marketed at the
         earliest possible time in order that products resulting therefrom may
         be available for public use and benefit.

1.3      LICENSEE desires a license under said Invention(s) and Licensed
         Patent(s) for commercialization of this technology.

1.4      The Invention(s) were made in the course of research supported by the
         National Institutes of Health.

2. DEFINITIONS

2.1      "Invention(s)" means any invention disclosed in Stanford Docket
         S95-024.


<PAGE>

2.2      "Licensed Patent(s)" means STANFORD's U.S. Patent Application, Serial
         Number 512,681 filed August 8, 1995 and any divisions, continuations,
         continuations-in-part, reexaminations or reissues of any such patent
         applications or patents.

2.3      "Licensed Field of Use" is for the detection of nucleic acid
         heteroduplex molecules.

3. GRANT

3.1      STANFORD hereby grants and LICENSEE hereby accepts a non-exclusive
         license to the Invention(s) and to the Licensed Patents in the Licensed
         Field of Use.

3.2      Said license of Paragraph 3.1 shall commence on August 20, 1997 and
         continue until expiration of the last to expire of Licensed Patent(s).

3.3      STANFORD acknowledges that future inventions and discoveries relating
         to this technology may be useful to LICENSEE in its development and/or
         commercialization process. Subject to STANFORD's obligations to
         sponsored research, STANFORD will, as soon as practicable, bring any
         such new invention and discovery related to this technology to
         LICENSEE's attention and provide LICENSEE a reasonable opportunity to
         negotiate a license therefor.

4.  GOVERNMENT RIGHTS

This Agreement is subject to all of the terms and conditions of Title 35 United
States Code Sections 200 through 204, and LICENSEE agrees to take all reasonable
action necessary on its part as licensee to enable STANFORD to satisfy its
obligation thereunder, relating to Invention(s).


<PAGE>

5. REPORTS

PROGRESS REPORT -- On or before August 25 of each year, beginning August 25,
1998, during the term of the Agreement, LICENSEE shall make a written annual
report to STANFORD covering the preceding year ending July 31, regarding the
progress of LICENSEE toward commercial use of the Invention(s) and Licensed
Patent(s). Such report shall include, as a minimum, information sufficient to
enable STANFORD to satisfy reporting requirements of the U.S. Government and for
STANFORD to ascertain progress by LICENSEE toward commercializing the
Invention(s) and Licensed Patent(s).

6. ROYALTIES

6.1      LICENSEE agrees to pay to STANFORD a nonrefundable license issue
         royalty of ** upon signing this Agreement. Such payment is due August
         25, 1997.

6.2      On August 25, 1998 and each August 25 thereafter, LICENSEE agrees to
         pay to STANFORD annual royalty payments of ** each year.

6.3      LICENSEE will also pay to STANFORD a one time, nonrefundable patent
         issue royalty of ** after the issuance of a Licensed Patent(s). Such
         payment is due within thirty (30) days after notification from
         STANFORD.

7.  NEGATION OF WARRANTIES

7.1      Nothing in this Agreement is or shall be construed as:

                  (a)      A warranty or representation by STANFORD as to the
                           validity or scope of any Licensed Patent(s);

                  (b)      A warranty or representation that anything made,
                           used, sold, or otherwise disposed of under any
                           license granted in this Agreement is or will be free
                           from infringement of patents, copyrights, and other
                           rights of third parties;

<PAGE>

                  (c)      An obligation to bring or prosecute actions or suits
                           against third parties for infringement; or

                  (d)      Granting by implication, estoppel, or otherwise any
                           licenses or rights under patents or other rights of
                           STANFORD or other persons other than to the
                           Invention(s) and Licensed Patent(s), regardless of
                           whether such patents or other rights are dominant or
                           subordinate to any Licensed Patent(s).

7.2      Except as expressly set forth in this Agreement, STANFORD MAKES NO
         REPRESENTATIONS AND EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS
         OR IMPLIED. THERE ARE NO EXPRESS OR IMPLIED WARRANTIES OF
         MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR THAT THE USE OF
         THE LICENSED PATENT(S) WILL NOT INFRINGE ANY PATENT, COPYRIGHT,
         TRADEMARK, OR OTHER RIGHTS OR ANY OTHER EXPRESS OR IMPLIED WARRANTIES.

7.3      LICENSEE agrees that nothing in this Agreement grants LICENSEE any
         express or implied license or right under or to:

                  (a)      U.S. Patent No. 4,237,224, "Process for Producing
                           Biologically Functional Molecular Chimeras," U.S.
                           Patent No. 4,468,464 and U.S. Patent No. 4,740,470,
                           both entitled, "Biologically Functional Molecular
                           Chimeras" (collectively known as the Cohen/Boyer
                           patents) or reissues thereof; or

                  (b)      U.S. Patent 4,656,134 "Amplification of Eucaryotic
                           Genes" or any patent application corresponding
                           thereto.

<PAGE>

8.  INDEMNITY

8.1      LICENSEE agrees to indemnify, hold harmless, and defend STANFORD and
         Stanford Health Services and their respective trustees, officers,
         employees, students, and agents against any and all claims for death,
         illness, personal injury, property damage, and improper business
         practices arising out of the manufacture, use, sale, or other
         disposition of Invention(s), Licensed Patent(s), or Licensed Product(s)
         by LICENSEE, or their customers.

8.2      STANFORD shall not be liable for any indirect, special, consequential,
         or other damages whatsoever, whenever grounded in tort (including
         negligence), strict liability, contract or otherwise. STANFORD shall
         not have any responsibilities or liabilities whatsoever with respect to
         Licensed Product(s).

8.3      LICENSEE shall at all times comply, through insurance or
         self-insurance, with all statutory workers' compensation and employers'
         liability requirements covering any and all employees with respect to
         activities performed under this Agreement.

8.4      In addition to the foregoing, LICENSEE shall maintain, during the term
         of this Agreement, Comprehensive General Liability Insurance, including
         Products Liability Insurance, with reputable and financially secure
         insurance carrier(s) to cover the activities of LICENSEE. Such
         insurance shall provide minimum limits of liability of Two Million
         Dollars ($2,000,000) and shall include STANFORD, Stanford Health
         Services, their trustees, directors, officers, employees, students, and
         agents as additional insureds. Such insurance shall be written to cover
         claims incurred, discovered, manifested, or made during or after the
         expiration of this Agreement. At STANFORD's request, LICENSEE shall
         furnish a Certificate of Insurance evidencing primary coverage and
         requiring thirty


<PAGE>

         (30) days prior written notice of cancellation or material change to
         STANFORD. LICENSEE shall advise STANFORD, in writing, that it maintains
         excess liability coverage (following form) over primary insurance for
         at least the minimum limits set forth above. All such insurance of
         LICENSEE shall be primary coverage; insurance of STANFORD or Stanford
         Health Services shall be excess and noncontributory.

9.  STANFORD NAMES AND MARKS

9.1      LICENSEE agrees not to identify STANFORD in any promotional advertising
         or other promotional materials to be disseminated to the public or any
         portion thereof or to use the name of any STANFORD faculty member,
         employee, or student or any trademark, service mark, trade name, or
         symbol of STANFORD or Stanford Health Services, or that is associated
         with either of them, without STANFORD's prior written consent.

9.2      LICENSEE with respect to sales, marketing, advertising or promotional
         materials disseminated concerning the technology covered by the
         Invention(s) and Licensed Patent(s) shall have the right to refer to
         and use the name, number(s), and owner(s) of the Invention(s) and
         Licensed Patent(s), as referred to in Paragraphs 2.1 and 2.2. LICENSEE
         may optionally use the following citation, and LICENSEE agrees when
         using said citation for sales, marketing, advertising, or promotional
         materials to use the entire citation written as follows:

         Oefner, Peter J., and Underhill, Peter A. (1995). Comparative DNA
         sequencing by denaturing high-performance liquid chromatography
         (DHPLC), Am. J. Hum. Genet. 57 {Suppl.}, A266.

<PAGE>

10.  INFRINGEMENT BY OTHERS: PROTECTION OF PATENTS

During the Non-exclusive period of this Agreement, STANFORD and LICENSEE agree
to discuss the appropriate course of action to be taken should either party be
aware of any suspected infringement of any Licensed Patent(s) by a third party.

11. SUBLICENSE(S)

Purchasers of equipment, columns, reagents and software from
LICENSEE for use in the Licensed Field of Use shall be deemed to have an implied
license under the Licensed Patent(s) to practice the inventions thereof and
shall be free from any suit brought based on the Licensed Patent(s). Otherwise,
LICENSEE may not grant sublicense(s).

12. TERMINATION

12.1     LICENSEE may terminate this Agreement by giving STANFORD notice in
         writing at least thirty (30) days in advance of the effective date of
         termination selected by LICENSEE.

12.2     STANFORD may terminate this Agreement if LICENSEE:

                  (a) Is in default in payment of royalty or providing of
                      reports;
                  (b) Is in breach of any provision hereof; or
                  (c) Provides any false report;

         and LICENSEE fails to remedy any such default, breach, or false report
         within ninety (90) days after written notice thereof by STANFORD.

12.3     Surviving any termination are:

                  (a) Any cause of action or claim of LICENSEE or STANFORD,
                      accrued or to accrue, because of any breach or default by
                      the other party; and
                  (b) The provisions of Articles 7 and 8.

<PAGE>

13.  ASSIGNMENT

This Agreement may not be assigned except to a successor in business of all or
substantially all the assets of LICENSEE.

14.  ARBITRATION

14.1     Any controversy arising under or related to this Agreement, and any
         disputed claim by either party against the other under this Agreement
         excluding any dispute relating to patent validity or infringement
         arising under this Agreement, shall be settled by arbitration in
         accordance with the Commercial Arbitration Rules of the American
         Arbitration Association.

14.2     Upon request by either party, arbitration will be by a third party
         arbitrator mutually agreed upon in writing by LICENSEE and STANFORD
         within thirty (30) days of such arbitration request. Judgment upon the
         award rendered by the arbitrator shall be final and nonappealable and
         may be entered in any court having jurisdiction thereof.

14.3     The parties shall be entitled to discovery in like manner as if the
         arbitration were a civil suit in the California Superior Court. The
         Arbitrator may limit the scope, time and/or issues involved in
         discovery.

14.4     Any arbitration shall be held at Stanford, California, unless the
         parties hereto mutually agree in writing to another place.

15.  NOTICES

All notices under this Agreement shall be deemed to have been fully given when
done in writing and deposited in the United States mail, registered or
certified, and addressed as follows:

<PAGE>

                              To STANFORD:        Office of Technology Licensing
                                                  Stanford University
                                                  900 Welch Road, Suite 350
                                                  Palo Alto, CA  94304-1850
                                                  Phone:  (650) 723-0651
                                                  Fax:    (650) 725-7295

                              Attention:          Director

                              To LICENSEE:        Transgenomic, Inc.
                                                  5600 South 42nd Street
                                                  Omaha, Nebraska  68107
                                                  Phone:  (402) 738-5480
                                                  Fax:    (402) 733-1264

                              Attention:          P. Thomas Pogge
                                                  General Counsel


Either party may change its address upon written notice to the other party.

16.  WAIVER

None of the terms of this Agreement can be waived except by the written consent
of the party waiving compliance.

17.  APPLICABLE LAW

This Agreement shall be governed by the laws of the State of California
applicable to agreements negotiated, executed and performed wholly within
California.

This Agreement constitutes the entire agreement between LICENSEE and STANFORD
and supersedes all prior communications, understandings and agreements with
respect to all matters covered in the Agreement.



<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Agreement in duplicate
originals by their duly authorized officers or representatives.


                           THE BOARD OF TRUSTEES OF THE LELAND
                           STANFORD JUNIOR UNIVERSITY

                           Signature        /s/ Katharine Ku
                                            --------------------------------
                           Name             Katharine Ku
                                            --------------------------------
                           Title            Director, Technology Licensing
                                            --------------------------------
                           Date             August 25, 1997
                                            --------------------------------

                           LICENSEE

                           Signature        /s/ Collin D'Silva
                                            --------------------------------
                           Name             Collin D'Silva
                                            --------------------------------
                           Title            Chief Executive Officer
                                            --------------------------------
                           Date             August 28, 1997
                                            --------------------------------

** Certain confidential portions of this Exhibit were omitted by means of
redacting a portion of the text indicated by two double-stricken through
asterisks "**". This Exhibit has been filed separately with the Secretary of the
Commission without the ** pursuant to the Registrant's Application Requesting
Confidential Treatment under Rule 406 of the Securities Act.



<PAGE>

                                                                   EXHIBIT 10.16


** Certain confidential portions of this Exhibit were omitted by means of
redacting a portion of the text indicated by two double-stricken through
asterisks "**". This Exhibit has been filed separately with the Secretary of the
Commission without the ** pursuant to the Registrant's Application Requesting
Confidential Treatment under Rule 406 of the Securities Act.


                                SUPPLY AGREEMENT

         THIS AGREEMENT (this "Agreement") is entered into as of March 10, 2000
by and between TRANSGENOMIC, INC., a Delaware corporation ("Transgenomic"), and
HITACHI INSTRUMENTS, INC., a California corporation ("HII"). (TRANSGENOMIC and
HII are hereinafter referred to jointly as the "Parties" and individually as a
"Party.")

         Section 1. SCOPE AND PURPOSE.

         (a)      HII agrees to sell to Transgenomic on a non-exclusive basis
                  certain equipment and related accessories as more fully set
                  forth in Exhibit A hereto ("Equipment") in accordance with the
                  terms and conditions of this Agreement. Exhibit A may be
                  amended from time to time by the addition, substitution or
                  modification of Equipment or the specifications relating
                  thereto as agreed to by the Parties.

         (b)      Transgenomic agrees to purchase from HII Transgenomic's
                  requirements for Equipment; provided that HII is able to
                  supply Equipment to Transgenomic meeting all agreed to
                  specifications set forth in Exhibit A hereto including, but
                  not limited to, those relating to performance and quality of
                  the Equipment, and is able to deliver Equipment to
                  Transgenomic in such quantities and at such times as is
                  required by Transgenomic.

         (c)      HII acknowledges that Transgenomic will incorporate Equipment
                  into one or more products manufactured by Transgenomic,
                  including its WAVE-Registered Trademark- products for the
                  separation of nucleic acids (the "Transgenomic Products").
                  Transgenomic reserves all rights to market Transgenomic
                  Products incorporating Equipment on a worldwide basis either
                  directly or through other third parties. Transgenomic shall
                  have the right to modify the Equipment in order to configure
                  the Equipment for a variety of uses in connection with its
                  needs.

         (d)      HII agrees to assist and support Transgenomic in modifications
                  of source code of the software HSM 3.0-20 as required for
                  implementation of Transgenomic applications. If such support
                  is deemed to be of significant expense to HII, then a mutually
                  agreed to fee will be paid by Transgenomic.

         Section 2. PURCHASING PROCEDURES.

         (a)      All purchases of Equipment by Transgenomic shall be made by
                  written purchase order issued to HII (a "Purchase Order") in a
                  form agreed to by the parties. Each Purchase Order shall
                  include, among other things, a description of Equipment to be
                  purchased, the quantity to be purchased, routing instructions,
                  delivery schedule, destination and confirmation of price. HII
                  agrees to accept telegraphic or telecopied (fax) Purchase
                  Orders. HII will deliver confirmation of the receipt of each
                  Purchase Order to Transgenomic within five (5) business days
                  of receipt by email or fax.

<PAGE>

          (b)     Except for the specific items set forth in Section 2(a),
                  special instructions or different or additional terms which
                  appear either on Transgenomic's Purchase Order or on HII's
                  confirmation form shall not apply unless mutually agreed to in
                  writing by duly authorized officers of each of the Parties.

          (c)     HII shall only accept blanket Purchase Orders that originate
                  from the following Transgenomic facility or other locations
                  designated by Transgenomic:

                             Transgenomic, Inc.
                             [Purchasing Department]
                             5600 South 42 Street
                             Omaha, NE  68107

          (d)     Under no circumstances is HII to proceed with the manufacture
                  or delivery of Equipment for Transgenomic under this Agreement
                  or otherwise without the receipt and confirmation of a
                  Purchase Order relating thereto. HII acknowledges and agrees
                  that Transgenomic will not be responsible for any costs or
                  expenses incurred by HII for materials, supplies, labor or
                  other commitments relating to the manufacture or delivery of
                  Equipment other than as authorized by Purchase Order duly
                  delivered to HII.

         Section 3. PRICES AND TERMS AND CONDITIONS OF SALE.

         (a)      PRICES. The price of Equipment and other terms and conditions
                  of sale are as stated in Exhibit B. Either Party may request a
                  renegotiation of the price together with the date on which
                  such price change will become effective. In the event the
                  Parties agree to a change in the specifications of Equipment,
                  such change will not become effective until the Parties have
                  agreed on a revised price and the conditions of sale for the
                  newly specified Equipment. Changes in specifications may only
                  be initiated by the following named individuals on behalf of
                  HII and Transgenomic:

                  Changes may be accepted only by Mark McDonald or his designee
                  on behalf of HII.

                  Changes may be accepted only by Collin J. D'Silva or his
                  designee on behalf of Transgenomic.

                  New Equipment types will be added to Exhibit A upon the mutual
                  agreement of both Parties. New Equipment added to Exhibit A
                  shall be accompanied by an amendment to Exhibit B which will
                  specify price and other terms and conditions.

         (b)      TAXES. The amount of any present, retroactive or future sales,
                  use, excise or similar tax applicable to Transgenomic's
                  purchase of Equipment shall be added to the HII invoice and
                  paid by Transgenomic unless Transgenomic provides HII with tax
                  exemption certificates acceptable to the appropriate taxing
                  authorities.


                                       2
<PAGE>

         (c)      PAYMENT. HII may invoice Transgenomic for Equipment sold
                  hereunder immediately upon delivery and Transgenomic shall pay
                  the full invoiced amount within forty five (45) days after the
                  date of HII's invoice.

         Section 4a. FORECASTS. Transgenomic will provide HII with a rolling
forecast of Transgenomic's estimated requirements for Equipment ("Forecast").
Each Forecast will relate to a four month period and will be delivered in
writing to HII at the address specified in Section 15 hereof no later than five
(5) business days after the first day of each month. In addition, no Forecast
shall be construed as a purchase order for Equipment. Transgenomic agrees to
place orders for a minimum of 75% of its Forecast for a given period. An initial
Forecast form is set forth in Exhibit C.

         Section 4b. DELIVERY. All deliveries shall be made FOB HII's San Jose
facilities, and title and risk of loss shall pass to Transgenomic at such
delivery point. HII will use reasonable efforts to deliver Equipment to a
carrier at such delivery point on the estimated shipment date for transportation
to the location(s) specified in Transgenomic's Purchase Order. Shipments shall
be in quantities specified in Purchase Orders. Shipping dates shall be the later
of five (5) days within receipt of the Purchase Order, or a date as specified on
the order, provided that if the quantity of Equipment which Transgenomic orders
for delivery in a month exceeds the quantity forecast for that month by more
than 25%, HII may exceed the five (5) day delivery requirement for a reasonable
period for that quantity that exceeds the Forecast. In the event HII is unable
to deliver to Transgenomic quantities as specified in Transgenomic's Purchase
Orders, Transgenomic reserves the right to cancel those Purchase Orders and
purchase from alternate sources. When HII is able to satisfy the production
requirements of Transgenomic, Transgenomic will resume purchasing from HII.

         Section 5. INSPECTION AND ACCEPTANCE. Transgenomic will inspect any
shipment of Equipment received from HII and will notify HII of any defects
within five (5) days after Transgenomic has discovered such defects. If
Transgenomic fails to notify HII of any such defects within such period, the
shipment shall be deemed accepted. Transgenomic will allow HII to inspect any
defective Equipment at Transgenomic's site. At the request of HII, Transgenomic
will ship to HII Equipment that Transgenomic believes is defective, provided HII
pays for the freight charges. HII agrees to replace all defective Equipment
rejected by Transgenomic or, at HII's option, to reimburse Transgenomic for the
full purchase price thereof, including any related shipping costs and taxes.

         Section 6. WARRANTY AND LIMITATION OF REMEDIES AND DISCLAIMER.

         (a)      HII warrants the Equipment to be free from defects in material
                  and manufacture and to conform to specifications set forth in
                  Exhibit A at the time of shipment. If any Equipment fails to
                  conform to the specifications or any defect in material or
                  manufacture appears within 24 months from the date of
                  shipment, HII's entire liability, and Transgenomic's exclusive
                  remedy, shall be, at HII's option, either to repair or replace
                  such defective Equipment within a reasonable time after
                  written notification thereof and return of the defective
                  Equipment to HII in San Jose, California.

                                       3
<PAGE>

         (b)      THIS WARRANTY IS MADE IN LIEU OF ALL OTHER WARRANTIES, EXPRESS
                  OR IMPLIED, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED
                  WARRANTY OF MERCHANTABILITY, THE IMPLIED WARRANTY OF FITNESS
                  FOR A PARTICULAR PURPOSE, ANY IMPLIED WARRANTY ARISING OUT OF
                  A COURSE OF DEALING OR OF PERFORMANCE, CUSTOM OR USAGE OF
                  TRADE EXCEPT OF TITLE AND AGAINST PATENT INFRINGEMENT.

         Section 7.  LIMITATION OF LIABILITIES; TIME LIMIT FOR FILING ACTION.

         (a)      NEITHER PARTY SHALL UNDER ANY CIRCUMSTANCES BE LIABLE TO EACH
                  OTHER FOR DAMAGES OF ANY KIND, INCLUDING, WITHOUT LIMITATION,
                  DIRECT, INDIRECT, INCIDENTAL, SPECIAL OR CONSEQUENTIAL DAMAGES
                  (INCLUDING, BUT NOT LIMITED TO, LOSS OF PROFITS, REVENUE OR
                  BUSINESS) RESULTING FROM OR IN ANY WAY RELATED TO THE
                  EQUIPMENT, ANY OF TRANSGENOMIC'S PURCHASE ORDERS, THIS
                  AGREEMENT OR THE TERMINATION OR NONRENEWAL OF THIS AGREEMENT.
                  This limitation applies regardless of whether such damages are
                  sought based on breach of contract, negligence, strict
                  liability in tort or any other legal theory.

         (b)      Any action for breach of warranty or any other obligation
                  under this Agreement must be commenced within one year after
                  the breach occurs.

         (c)      Each limitation on liability or limited or exclusive remedy
                  set forth in this Agreement is independent of any other
                  limitation or remedy and if any such limitation or remedy
                  fails of its essential purpose or is otherwise held to be
                  unenforceable, that shall not affect the validity of any other
                  such limitation or remedy.

         Section 8.  TECHNICAL SUPPORT AND SERVICING OF EQUIPMENT.

         (a)      HII agrees to provide all available technical support and
                  literature, including information on the use of the Equipment
                  being supplied to Transgenomic to facilitate its use in
                  Transgenomic Products.

         (b)      HII shall make available for purchase all necessary
                  consumables, accessories and spare parts for the operation,
                  repair and proper servicing of each unit of Equipment to
                  Transgenomic and to Transgenomic's customers for a period of
                  seven years following the date of the delivery of the
                  Equipment. This provision shall survive termination of this
                  Agreement.

         (c)      HII shall provide, free of charge, Transgenomic with all
                  necessary copies (maximum of three copies) of all manuals,
                  brochures and part price lists concerning the servicing of
                  each unit of Equipment. Hitachi will make no provision to
                  re-label or otherwise modify such manuals, brochures and part
                  price lists without a prior written agreement.

                                       4
<PAGE>

         Section 9. PRODUCT IDENTIFICATION AND LABELING. All Transgenomic
Products shall carry the Transgenomic name (or other name designated by
Transgenomic) and will not use the HII brand name except as mutually agreed to
by the Parties. There shall be no obligation on the part of Transgenomic to
purchase or acquire any right to use the HII name or any other trademark,
tradename or other symbol or designation used by HII or to make any reference to
HII on any Equipment or Transgenomic Products incorporating Equipment.

         Section 10.  CONFIDENTIAL INFORMATION.

         (a)      "Confidential Information" shall mean all such confidential
                  and proprietary information of any kind, whether or not fixed
                  in a tangible medium, including, without limitation, systems
                  concepts, drawings, models, software embodiments,
                  specifications, plans, designs, marketing plans, identity of
                  customers, trade secrets and technical data, as either of the
                  Parties (the disclosing Party) may designate as confidential
                  upon disclosure to the other (the receiving Party). For the
                  purposes of this Agreement, appropriate words of designation
                  include, without limitation, the words "Confidential" or
                  "Proprietary." Any information disclosed orally by either
                  Party shall not be considered "Confidential Information"
                  unless clearly identified as confidential or proprietary at
                  the time of such oral disclosure and summarized by the
                  disclosing Party in a writing which is clearly marked
                  "confidential" or "proprietary" and sent to the recipient
                  Party within 30 days after the initial oral disclosure.
                  Confidential Information includes the existence and terms of
                  this Supply Agreement.

         (b)      Confidential Information shall not include any information
                  that the receiving Party reasonably establishes:

                  (i)      was in the public domain at the time the receiving
                           Party learns of it, or later becomes publicly known
                           through no wrongful act of the receiving Party;

                  (ii)     was known to the receiving Party prior to the date of
                           their Agreement, as shown by written records of the
                           receiving Party, and was not subject to prior
                           confidentiality obligations with the disclosing
                           Party;

                  (iii)    was received by the receiving Party from a third
                           party who had a lawful right to disclose it to the
                           receiving Party and no obligation to maintain the
                           confidentiality of such information;

                  (iv)     was independently developed by the receiving Party
                           without the use of or reference to the Confidential
                           Information of the disclosing Party; provided,
                           however, that such information as is not included
                           within Confidential Information because it meets the
                           conditions of subsection (b)(i), (iii), or (iv) or of
                           this Section 10 shall be deemed to be Confidential
                           Information until the date it becomes public
                           knowledge, is independently developed, is received
                           from a third party or is approved for release, as the
                           case may be.

         (c)      All Confidential Information received under this Agreement
                  shall be treated by the recipient Party with reasonable care
                  to assure that the confidentiality of such

                                       5
<PAGE>

                  Confidential Information is maintained, and that such
                  Confidential Information is not distributed, disclosed or
                  disseminated in any way to anyone except employees of the
                  recipient Party who are involved in the work related to this
                  Agreement and who have a need to know such information.

         (d)      All rights the disclosing Party may have in Confidential
                  Information prior to disclosure, including, without
                  limitation, rights of patent, copyright and trade secret,
                  shall remain exclusively with the disclosing Party, and
                  nothing in this Agreement shall be construed as granting any
                  license, waiver or other right to the receiving Party with
                  respect to Confidential Information.

         (e)      Each of the Parties shall have the right to refuse to receive
                  any information under this Agreement and nothing in this
                  Agreement shall obligate either Party to disclose to the other
                  any information whatsoever.

         (f)      The receiving Party shall promptly return all Confidential
                  Information to the disclosing Party upon termination of this
                  Agreement or at any time upon request and shall certify,
                  represent and warrant that all such Confidential Information
                  and copies and extracts thereof have been returned or
                  destroyed, provided that the recipient Party may retain one
                  copy of the Confidential Information for archival purposes in
                  the event of a dispute as to the Confidential Information
                  received.

         (g)      The Parties agree that the production processes used by HII to
                  manufacture Equipment covered by this Agreement are
                  confidential and will be treated as Confidential Information
                  under this Agreement and are proprietary to HII. In addition,
                  the Parties agree that the specifications of Equipment covered
                  by this Agreement as supplied by Transgenomic are Confidential
                  Information and proprietary to HII and will be treated as
                  Confidential Information under this Agreement. The Parties
                  agree that the production processes used by Transgenomic to
                  manufacture Transgenomic Products are confidential and will be
                  treated as Confidential Information under this Agreement and
                  are proprietary to Transgenomic. In addition, the Parties
                  agree that the specifications of Transgenomic Products are
                  Confidential Information and proprietary to Transgenomic and
                  will be treated as Confidential Information under this
                  Agreement. All such treatment shall be effective without
                  regard to whether the subject information is specifically
                  designated as confidential under Section 10(a).

         Section 11.  INDEMNIFICATION.

         (a)      HII will indemnify, defend and hold harmless Transgenomic and
                  its directors, officers, agents and employees from any loss,
                  claim, liability and expense (including reasonable attorneys'
                  fees and other expenses of litigation) with respect to:

                  (i)      workers' compensation benefits payable on account of
                           sickness, injury or death of any HII employee, or to
                           any employee of HII's subcontractors, agents or
                           delegates, where the sickness, injury or death arises
                           out of or is in

                                       6
<PAGE>

                           any way related to the work performed or to be
                           performed under this Agreement; and

                  (ii)     claims for sickness, bodily injury, personal injury,
                           death, property damage or loss as asserted by third
                           parties (including employees of HII or by HII's
                           subcontractors, agents or delegates, or by any other
                           person at HII's plant), where the claim is based in
                           whole or in any part on, or is in any way related to,
                           any act or omission attributable to HII, its agents,
                           employees or subcontractors, or in any way related to
                           the work performed or to be performed or the
                           Equipment supplied under this Agreement, except to
                           the extent that such claims are due solely and
                           directly to the negligence of Transgenomic.

         (b)      HII agrees that the indemnities stated in subsection 11(a)
                  should be construed and applied in favor of indemnification.
                  To the extent permitted by law, the stated indemnities apply
                  (i) regardless of any strict liability or negligence
                  attributable to Transgenomic (excluding sole negligence) and
                  (ii) regardless of the extent to which the underlying harm is
                  attributable to the negligent or otherwise wrongful act or
                  omission (including breach of contract) of HII, its
                  subcontractors, agents or employees. HII also agrees that if
                  applicable law limits or precludes any aspect of the stated
                  indemnities, then the indemnities will be considered limited
                  only to the extent necessary to comply with that applicable
                  law. The stated indemnities continue until all applicable
                  statutes of limitations have run.

         Section 12.  TERM AND TERMINATION.

         (a)      TERM. The term of this Agreement begins on the date first
                  above written and continues until terminated by either Party
                  as provided herein.

         (b)      TERMINATION WITH CAUSE. Either Party may terminate this
                  Agreement during the term of this Agreement, upon written
                  notice, sent registered or certified mail, return receipt
                  requested, in the event the other Party fails to perform a
                  material obligation under this Agreement or otherwise is in
                  breach of any of its material obligations hereunder. Failure
                  to perform or breach of a material obligation includes,
                  without limitation, (i) failure to deliver Equipment as agreed
                  to by the Parties or (ii) failure of the Equipment delivered
                  to Transgenomic to conform to the specifications. The Party
                  receiving such notice shall have 30 days from the date of
                  receipt thereof to cure the failure or breach. If the Party
                  receiving such notice does not cure the failure or breach
                  within such cure period, the Party claiming breach may
                  terminate this Agreement by sending written notice of
                  termination, by certified mail, return receipt requested. The
                  issuance of a Blanket Purchase Order Release during the 30-day
                  cure period does not waive the notice of breach. If HII has
                  the right to terminate this Agreement pursuant to this Section
                  12(b), or has demanded cure of a Transgenomic default pursuant
                  hereto which has not yet been cured, HII may also suspend its
                  performance under this Agreement and any individual sales
                  contracts concluded pursuant hereto and, by written demand to
                  Transgenomic, cause all amounts owed to it by Transgenomic
                  which are not yet due to become immediately due and payable.

                                       7
<PAGE>

         (c)      TERMINATION WITHOUT CAUSE. Transgenomic or HII may terminate
                  this Agreement at any time without having to state,
                  demonstrate or possess cause by giving written notice of
                  termination to the other party at least 180 days prior to the
                  effective date of termination.

         (d)      ORDER AFTER TERMINATION. Any order placed by Transgenomic and
                  accepted by HII after the termination of this Agreement is
                  governed by the provisions of this Agreement. The placing or
                  acceptance of post-termination or shipment of post-termination
                  orders does not otherwise extend the term of this Agreement.
                  Notwithstanding the foregoing, if terminated by HII pursuant
                  to Section 12(c), Transgenomic shall have the option to
                  purchase during the six month period after termination, the
                  quantity of Equipment equivalent to three times its previous
                  six-month's purchases and such purchases shall be governed by
                  this Agreement, and if terminated by Transgenomic pursuant to
                  Section 12(c), Transgenomic shall have the obligation to
                  purchase the quantity of Equipment equal to its current four
                  month Forecast or the prior four month period if no forecast
                  has been provided, and such purchases shall be governed by
                  this Agreement.

         (e)      EFFECT OF TERMINATION OR NONRENEWAL. The termination of this
                  Agreement shall not release either Party from the obligation
                  to pay any sum that may be owing (whether then or thereafter
                  due) or operate to discharge any liability that had been
                  incurred by either Party prior to any such termination. The
                  provisions of Sections 3(b), 3(c), 6, 7, 10, 11, 12(d), 12(e),
                  and 13 through 21, shall survive any termination of this
                  Agreement.

         Section 13. EXCUSED PERFORMANCE. No Party shall be liable for or be
deemed to be in default on account of any failure to perform (except payment of
HII's invoices) if due to any cause or condition beyond reasonable control of
the nonperforming Party.

         Section 14. RELATIONSHIP OF THE PARTIES. The relationship established
between HII and Transgenomic by this Agreement is that of a vendor to its
vendee. No Party is an agent of another Party and no Party has authority to bind
another Party, transact any business in another Party's name or on its behalf in
any manner or make any promises or representations on behalf of another Party.

         Section 15. NOTICES. All notices and other communications shall be in
writing and shall be deemed to have been given when received. Any notice to be
given to Transgenomic shall be addressed to:

                            Transgenomic, Inc.
                            5600 South 42 Street
                            Omaha, NE  68107
                            USA
                            Attention:  Collin J. D'Silva
                            Telephone:  (402) 738-5480
                            Telecopier:  (402) 733-1264

                                       8
<PAGE>

Any notice to HII shall be addressed to:

                            Hitachi Instruments, Inc.
                            3100 North First Street
                            San Jose, CA 95134
                            USA
                            Attention:  Mark McDonald
                            Telephone: (408) 955-7001
                            Telecopier: (408) 432-8258

Any change in address shall be promptly communicated by either Party to the
other Party.

         Section 16. NO ASSIGNMENT. No Party shall assign its rights or delegate
its duties under this Agreement without written consent of the other Party. Any
assignment, delegation or transfer of this Agreement or any interest herein is
void and cause for termination of this Agreement.

         Section 17. WAIVER. Any failure or delay by any Party in exercising any
right or remedy in one or many instances will not prohibit a Party from
exercising it at a later time or from exercising any other right or remedy.

         Section 18. MODIFICATION. No part of this Agreement may be waived,
modified or supplemented in any manner whatsoever (including a course of dealing
or of performance or usage of trade) except by a written document signed by
authorized officers of the Parties.

         Section 19. GOVERNING LAW. This Agreement and any questions, claims,
disputes or litigation concerning or arising from this Agreement shall be
governed by the laws of California, United States of America without giving
effect to the conflicts of law doctrines of any state, provided that the Federal
Arbitration Act shall apply in place of and instead of the California
Arbitration Act and the California International Arbitration Act.

         Section 20. ENTIRE AGREEMENT. This Agreement and the Exhibits referred
to in this Agreement, which Exhibits are incorporated and made a part of this
Agreement by this reference, supersede and terminate any and all prior
agreements, if any, whether written or oral, between the Parties with respect to
the subject matter contained herein. Each Party agrees that it has not relied on
any representation, warranty or provision not explicitly stated in this
Agreement and that no oral statement has been made to either Party that in any
way tends to waive any of the terms or conditions of this Agreement. This
Agreement constitutes the final written expression of all terms of the
Agreement, and it is a complete and exclusive statement of those terms.

         Section 21. DISPUTE RESOLUTION. The parties agree that all disputes
arising in connection with this Agreement shall be finally settled by binding
arbitration under the Commercial Arbitration Rules of the American Arbitration
Association by one or more arbitrators appointed in accordance with said rules
and taking place in San Jose, California USA. If a party commences any action or
proceeding against the other party to enforce this Agreement or any rights
related thereto, the prevailing party in such action or proceeding shall be
entitled to recover from the other party the reasonable attorneys' fees and
other costs and expenses incurred

                                       9
<PAGE>

by that prevailing party in connection with such action or proceeding and in
connection with enforcing any judgment, award or order thereby obtained.

         IN WITNESS WHEREOF, the Parties hereto have executed this Agreement as
of the date first above written.

                                TRANSGENOMIC, INC.


                                By  /s/ COLLIN J. D'SILVA
                                   --------------------------------------------
                                   Collin J. D'Silva, Chief Executive Officer



                                HITACHI INSTRUMENTS, INC.


                                By /s/ MARK MCDONALD
                                   --------------------------------------------
                                Mark McDonald, President


                                       10
<PAGE>

                                    EXHIBIT A


                    EQUIPMENT DESCRIPTION AND SPECIFICATIONS


The nucleic acid analysis unit shall contain at a minimum the following
components:

<TABLE>
<CAPTION>
ITEM P/N          DESCRIPTION                  QPA
- --------------------------------------------------
<S>               <C>                          <C>

                  **







</TABLE>


Changes in specifications may be initialized only by authorized individuals on
behalf of HII and Transgenomic.


                                       11
<PAGE>

                                    EXHIBIT B

                           EQUIPMENT PRICES AND TERMS


The instrument as specified in Exhibit A will be $** per system with no
minimum purchase order requirement, or for individual components, prices will be
as follows:

<TABLE>
<CAPTION>
ITEM  P/N           DESCRIPTION                     QPA    UNIT PRICE   EXTENSION
- --------------------------------------------------------------------------------
<S>   <C>           <C>                              <C>       <C>       <C>

                    **











</TABLE>

NOTE: COMMENCING MAY 15, 2000, ITEMS 19 AND 20 WILL REPLACE ITEMS 4 AND 5,
RESPECTIVELY. AT SUCH TIME THE EFFECTIVE SYSTEM PRICE WILL BE $**.

                                       12
<PAGE>

TERMS AND CONDITIONS

TERMS

         I.     The following terms apply to all purchase orders. These terms
                supersede the terms that may be printed on the purchase order.

                A. FOB Point is "San Jose, CA".
                B. Shipments will not be insured unless they are in excess of
                   $400,000. If a shipment is in excess of $400,000, HII will
                   insure the shipment at Transgenomic's expense.
                C. Shipment charges will be prepaid by HII and added to invoice.
                D. For orders in excess of $75,000, payment will be due 45
                   days from date of shipment with payment secured by Bank
                   Draft for an additional charge of $120. For orders of
                   $75,000 or less, payment will be due 30 days from date of
                   shipment.

         II.    All Orders are subject to credit review. Current Bank Draft
                Credit Limit is $1,000,000 and the open line of credit is
                $120,000. Credit limits are subject to periodic review.

         III.   HII will not accept unsigned purchase orders or unsigned
                releases against a signed purchase order.

         IV.    For purchase orders where the shipping method is either
                unspecified or specified as "Best Way", shipment will be (3-5
                day ground service) determined by HII.

CONDITIONS

         I.     The accompanying pricing schedule may be voided, at HII's
                discretion, if a system component supplied by HII is removed
                from the system configuration by Transgenomic. The only
                exception to this condition is AN0-0371, the modified L-7300
                column oven.

         II.    Pricing is effective immediately upon execution of this
                document by both parties.

         III.   This agreement does not provide for modifications to any
                existing purchase order. Such modifications, cancellations,
                substitutions, or otherwise, to purchase orders that have
                already been received by HII, are expressly forbidden.

                                       13
<PAGE>

                                    EXHIBIT C

                                INITIAL FORECAST

Pursuant to Section 4(a), Transgenomic forecasts the following items of
Equipment for delivery in each of the initial four months of this Agreement:


<TABLE>
<CAPTION>
MONTH                                EQUIPMENT
- ----------------------------------------------
<S>                                  <C>

April 2000

May 200

June 2000

July 2000
</TABLE>


** Certain confidential portions of this Exhibit were omitted by means of
redacting a portion of the text indicated by two double-stricken through
asterisks "**". This Exhibit has been filed separately with the Secretary of the
Commission without the ** pursuant to the Registrant's Application Requesting
Confidential Treatment under Rule 406 of the Securities Act.


                                       14

<PAGE>

                                                                   EXHIBIT 10.17


                       STANDARD INDUSTRIAL LEASE -- GROSS

                   AMERICAN INDUSTRIAL REAL ESTATE ASSOCIATION

1. PARTIES. This Lease, dated, for reference purposes only, November 2, 1998, is
made by and between Westlake Development Company, Inc. (herein called "Lessor")
and Transgenomic, Inc. (herein called "Lessee").

2. PREMISES. Lessor hereby leases to Lessee and Lessee leases from Lessor for
the term, at the rental, and upon all of the conditions set forth herein, that
certain real property situated in the County of Santa Clara, State of California
commonly known as 2030 Concourse Drive, San Jose and described as Containing
approximately 5,250 square feet of light industrial space being a part of a
larger building.

Said real property including the land and all improvements therein, is herein
called "the Premises."

3. TERM.

     3.1 TERM. The term of this Lease shall be for forty three (43) months
commencing on November 1, 1988 and ending on May 31, 2002 unless sooner
terminated pursuant to any provision hereof.

     3.2 DELAY IN POSSESSION. Notwithstanding said commencement date, if for any
reason Lessor cannot deliver possession of the Premises to Lessee on said date,
Lessor shall not be subject to any liability therfor, nor shall such failure
affect the validity of this Lease or the obligations of Lessee hereunder or
extend the term hereof, but in such case, Lessee shall not be obligated to pay
rent until possession of the Premises is tendered to Lessee provided, however,
that if Lessor shall not have delivered possession of the Premises within sixty
(60) days from said commencement date, Lessee may, at Lessee's option, by notice
in writing to Lessor within ten (10) days thereafter, cancel this Lease, in
which event the parties shall be discharged from all obligations hereunder;
provided further, however, that if such written notice of Lessee is not received
by Lessor within said ten (10) day period, Lessee's right to cancel this Lease
hereunder shall terminate and be of no further force or effect.

     3.3 EARLY POSSESSION. If Lessee occupies the Premises prior to said
commencement date, such occupancy shall be subject to all provisions hereof,
such occupancy shall not advance the termination date, and Lessee shall pay rent
for such period at the initial monthly rates set forth below.

4. RENT. Lessee shall pay to Lessor as rent for the Premises, monthly payments
of $7,297.50, in advance, on the first day of each month of the term hereof.
Lessee shall pay Lessor upon the execution hereof $7,297.50 as rent for November
1, 1998 through November 30, 1998

See Addendum #47 for rent schedule

Rent for any period during the term hereof which is for less than one month
shall be a pro rata portion of the monthly installment. Rent shall be payable in
lawful money of the United States to Lessor at the address stated herein or to
such other persons or at such other places as Lessor may designate in writing.

5. SECURITY DEPOSIT. Lessee shall deposit with Lessor upon execution hereof
$7,297.50 as security for Lessee's faithful performance of Lessee's obligations
hereunder. If Lessee fails to pay rent or other charges due hereunder, or
otherwise defaults with respect to any provision of this Lease, Lessor may use,
apply or retain all or any portion of said deposit for the payment of any rent
or other charge in default or for the payment of any other sum to which Lessor
may become obligated by reason of Lessee's default, or to compensate Lessor for
any loss or damage which Lessor may suffer thereby. If Lessor so uses or applies
all or any portion of said deposit, Lessee shall within ten (10) days after
written demand therefor deposit cash with Lessor in an amount sufficient to
restore said deposit to the full amount hereinabove stated and Lessee's failure
to do so shall be a material breach of this Lease. If the monthly rent shall,
from time to time, increase during the term of this Lease, Lessee shall
thereupon deposit with Lessor additional security deposit so that the amount of
security deposit held by Lessor shall at all times bear the same proportion to
current rent as the original security deposit bears to the original monthly rent
set forth in paragraph 4 hereof. Lessor shall not be required to keep said
deposit separate from its general accounts. If Lessee performs all of Lessee's
obligations hereunder, said deposit, or so much thereof as has not theretofore
been applied by Lessor, shall be returned, without payment of interest or other
increment for its use, to Lessee (or, at Lessor's option, to the last assignee,
if any, of Lessee's interest hereunder) at the expiration of the term hereof,
and after


<PAGE>

Lessee has vacated the Premises. No trust relationship is created herein between
Lessor and Lessee with respect to said Security Deposit.

6. USE.

         6.1 USE. The Premises shall be used and occupied only for manufacturing
and sales of chromatograph products and related legal uses, or any other use
which is reasonably comparable and for no other purpose.

         6.2  COMPLIANCE WITH LAW.

         (a) Lessor warrants to Lessee that the Premises, in its state existing
on the date that the Lease term commences, but without regard to the use for
which Lessee will use the Premises, does not violate any covenants or
restrictions of record, or any applicable building code, regulation or ordinance
in effect on such Lease term commencement date. In the event it is determined
that this warranty has been violated, then it shall be the obligation of the
Lessor, after written notice from Lessee, to promptly, at Lessor's sole cost and
expense, rectify any such violation. In the event Lessee does not give to Lessor
written notice of the violation of this warranty within six months from the date
that the Lease term commences, the correction of same shall be the obligation of
the Lessee at Lessee's sole cost. The warranty contained in this paragraph
6.2(a) shall be of no force or effect if, prior to the date of this Lease,
Lessee was the owner or occupant of the Premises, and, in such event, Lessee
shall correct any such violation at Lessee's sole cost.

         (b) Except as provided in paragraph 6.2(a), Lessee shall, at Lessee's
expense, comply promptly with all applicable statutes, ordinances, rules,
regulations, orders, covenants and restrictions of record, and requirements in
effect during the term or any part of the term hereof, regulating the use by
Lessee of the Premises. Lessee shall not use nor permit the use of the Premises
in any manner that will tend to create waste or a nuisance or, if there shall be
more than one tenant in the building containing the Premises, shall tend to
disturb such other tenants.

         6.3  CONDITION OF PREMISES.

         (a) Lessor shall deliver the Premises to Lessee clean and free of
debris on Lease commencement date (unless Lessee is already in possession) and
Lessor further warrants to Lessee that the plumbing, lighting, air conditioning,
heating, and loading doors in the Premises shall be in good operating condition
on the Lease commencement date. In the event that it is determined that this
warranty has been violated, then it shall be the obligation of Lessor, after
receipt of written notice from Lessee setting forth with specificity the nature
of the violation, to promptly, at Lessor's sole cost, rectify such violation.
Lessee's failure to give such written notice to Lessor within thirty (30) days
after the Lease commencement date shall cause the conclusive _____________ that
Lessor has _____________ with all of Lessor's obligations hereunder. The
warranty contained in this paragraph 6.3(a) ________________________ was the
owner of occupant of the Premises.

         (b) Except as otherwise provided in this Lease, Lessee hereby accepts
the Premises in their condition existing as of the Lease commencement date or
the date that Lessee takes possession of the Premises, whichever is earlier,
subject to all applicable zoning, municipal county and state laws, ordinances
and regulations governing and regulating the use of the Premises, and any
covenants or restrictions of record and accepts this lease subject thereto and
to all matters disclosed thereby and by any exhibits attached hereto. Lessee
acknowledges that neither Lessor nor Lessor's agent has made any representation
or warranty as to the present or future suitability of the Premises for the
conduct of the Lessee's business.

7. MAINTENANCE, REPAIRS AND ALTERATIONS.

         7.1 LESSOR'S OBLIGATIONS. Subject to the provisions of Paragraphs 6,
7.2, and 9 and except for damage caused by any negligent or intentional act or
omission of Lessee, Lessee's agents, employees, or invitees in which event
Lessee shall repair the damage, Lessor, at Lessor's expense shall keep in good
order, condition and repair the foundations, exterior walls and the exterior
roof of the Premises. Lessor shall not, however, be obligated to paint such
exterior, nor shall Lessor be required to maintain the interior surface of
exterior walls, windows, doors or plate glass. Lessor shall have no obligation
to make repairs under this Paragraph 7.1 until a reasonable time after receipt
of written notice of the need for such repairs. Lessee expressly waives the
benefits of any statute now or hereafter in effect which would otherwise afford
Lessee the right to make repairs at Lessor's expense or to terminate this Lease
because of Lessor's failure to keep the Premises in good order, condition and
repair.


                                      -2-
<PAGE>

         7.2  LESSEE'S OBLIGATIONS.

         (a) Subject to the provisions of Paragraphs 6, 7.1 and 9, Lessee, at
Lessee's expense, shall keep in good order, condition and repair the Premises
and every part thereof (whether or not the damaged portion of the Premises or
the means of repairing the same are reasonably or readily accessible to Lessee)
including, without limiting the generality of the foregoing, all plumbing,
heating, air conditioning, (Lessee shall procure and maintain, at Lessee's
expense, an air conditioning system maintenance contract) ventilating,
electrical and lighting facilities and equipment within the Premises, fixtures,
interior walls and interior surface of exterior walls, ceilings, windows, doors,
plate glass, and skylights located within the Premises, and all landscaping,
driveways, parking lots, fences and signs located in the Premises and all
sidewalks and parkways adjacent to the Premises.

         (b) If Lessee fails to perform Lessee's obligations under this
Paragraph 7.2 or under any other paragraph of this Lease, Lessor may at Lessor's
option enter upon the Premises after 10 days' prior written notice to Lessee
(except in the case of emergency, in which case no notice shall be required),
perform such obligations on Lessee's behalf and put the Premises in good order,
condition and repair, and the cost thereof together with interest thereon at the
maximum rate then allowable by law shall be due and payable as additional rent
to Lessor together with Lessee's next rental installment.

         (c) On the last day of the term hereof, or on any sooner termination,
Lessee shall surrender the Premises to Lessor in the same condition as received,
ordinary wear and tear excepted, clean and free of debris. Lessee shall repair
any damage to the Premises occasioned by the installation or removal of its
trade fixtures, furnishings and equipment. Notwithstanding anything to the
contrary otherwise stated in this Lease Lessee shall leave the air lines, power
panels, electrical distribution systems, lighting fixtures, space heaters, air
conditioning, plumbing and fencing on the premises in good operating condition.

         7.3  ALTERATIONS AND ADDITIONS.

         (a) Lessee shall not, without Lessor's prior written consent make any
alterations, improvements, additions, or Utility installations in, on or about
the Premises, except for nonstructural alterations not exceeding $5,000 in
cumulative costs during the term of this Lease. In any event, whether or not in
excess of $5,000 in cumulative costs, Lessee shall make no change or alteration
to the exterior of the Premises nor the exterior of the building(s) on the
Premises without Lessor's prior written consent. As used in this Paragraph 7.3
the term "Utility installation" shall mean carpeting, window coverings, air
lines, power panels, electrical distribution systems, lighting fixtures, space
heaters, air conditioning, plumbing, and fencing. Lessor may require that Lessee
remove any or all of said alterations, improvements, additions or Utility
installations at the expiration of the term, and restore the Premises to their
prior condition. Lessor may require Lessee to provide Lessor, at Lessee's sole
cost and expense, a lien and completion bond in an amount equal to one and
one-half times the estimated cost of such improvements, to insure Lessor against
any liability for mechanic's and materialmen's liens and to insure completion of
the work. Should Lessee make any alterations, improvements, additions or Utility
Installations without the prior approval of Lessor, Lessor may require that
Lessee remove any or all of the same.

         (b) Any alterations, improvements, additions or Utility Installations
in, or about the Premises that Lessee shall desire to make and which requires
the consent of the Lessor shall be presented to Lessor in written form, with
proposed detailed plans. If Lessor shall give its consent, the consent shall be
deemed conditioned upon Lessee acquiring a permit to do so from appropriate
governmental agencies, the furnishing of a copy thereof to Lessor prior to the
commencement of the work and the compliance by Lessee of all conditions of said
permit in a prompt and expeditious manner.

         (c) Lessee shall pay, when due, all claims for labor or materials
furnished or alleged to have been furnished to or for Lessee at or for use in
the Premises, which claims are or may be secured by any mechanics' or
materialmen's lien against the Premises or any interest therein. Lessee shall
give Lessor not less than ten (10) days' notice prior to the commencement of any
work in the Premises, and Lessor shall have the right to post notices of
non-responsibility in or on the Premises as provided by law. If Lessee shall, in
good faith, contest the validity of any such lien, claim or demand, then Lessee
shall, at its sole expense defend itself and Lessor against the same and shall
pay and satisfy any such adverse judgment that may be rendered thereon before
the enforcement thereof against the Lessor or the Premises, upon the condition
that if Lessor shall require, Lessee shall furnish to Lessor a surety bond
satisfactory to Lessor in an amount equal to such contested lien claim or demand
indemnifying Lessor against liability for the same and holding the Premises free
from the effect of such lien or claim. In addition, Lessor



                                      -3-
<PAGE>

may require Lessee to pay Lessor's attorneys fees and costs in participating in
such action if Lessor shall decide it is to its best interest to do so.

         (d) Unless Lessor requires their removal, as set forth in Paragraph
7.3(a), all alterations, improvements, additions and Utility Installations
(whether or not such Utility Installations constitute trade fixtures of Lessee),
which may be made on the Premises, shall become the property of Lessor and
remain upon and be surrendered with the Premises at the expiration of the term.
Notwithstanding the provisions of this Paragraph 7.3(d), Lessee's machinery and
equipment, other than that which is affixed to the Premises so that it cannot be
removed without material damage to the Premises, shall remain the property of
Lessee and may be removed by Lessee subject to the provisions of Paragraph
7.2(c).

8. INSURANCE; INDEMNITY.

         8.1 LIABILITY INSURANCE - LESSEE. Lessee shall, at Lessee's expense,
obtain and keep in force during the term of this Lease a policy of Combined
Single Limit Bodily Injury and Property Damage Insurance insuring Lessee and
Lessor against any liability arising out of the use, occupancy or maintenance of
the Premises and all other areas appurtenant thereto. Such insurance shall be in
an amount not less than $500,000 per occurrence. The policy shall insure
performance by Lessee of the indemnity provisions of this Paragraph 8. The
limits of said insurance shall not, however, limit the liability of Lessee
hereunder.

         8.2 LIABILITY INSURANCE - LESSOR. Lessor shall obtain and keep in force
during the term of this Lease a policy of Combined Single Limit Bodily Injury
and Property Damage Insurance, insuring Lessor, but not Lessee, against any
liability arising out of the ownership, use, occupancy or maintenance of the
Premises and all areas appurtenant thereto in an amount not less than $500,000
per occurrence.

         8.3 PROPERTY INSURANCE. Lessor shall obtain and keep in force during
the term of this Lease a policy or policies of insurance covering loss or damage
to the Premises, but not Lessee's fixtures, equipment or tenant improvements in
an amount not to exceed the full replacement value thereof, as the same may
exist from time to time, providing protection against all perils included within
the classification of fire, extended coverage, vandalism, malicious mischief,
flood (in the event same is required by a lender having a lien on the Premises)
special extended perils ("all risk", as such term is used in the insurance
industry) but not plate glass insurance. In addition, the Lessor shall obtain
and keep in force, during the term of this Lease, a policy of rental value
insurance covering a period of one year, with loss payable to Lessor, which
insurance shall also cover all real estate taxes and insurance costs for said
period.

         8.4  PAYMENT OF PREMIUM INCREASE.

         (a) Lessee shall pay to Lessor, during the term hereof, in addition to
the rent, the amount of any increase in premiums for the insurance required
under Paragraphs 8.2 and 8.3 over and above such premiums paid during the Base
period, as hereinafter defined, whether such premium increased shall be the
result of the nature of Lessee's occupancy, any act or omission of Lessee,
requirements of the holder of a mortgage or deed of trust covering the Premises,
increased valuation of the Premises, or general rate increases. In the event
that the Premises have been occupied previously, the words "Base Period" shall
mean the last twelve months of the prior occupancy. In the event that the
Premises have never been previously occupied, the premiums during the "Base
period" shall be deemed to be the lowest premiums reasonably obtainable for said
insurance assuming the most nominal use of the Premises. Provided, however, in
lieu of the Base Period, the parties may insert a dollar amount at the end of
this sentence which figure shall be considered as the insurance premium for the
Base Period: $__________________. In no event, however, shall Lessee be
responsible for any portion of the premium cost attributable to liability
insurance in excess of $1,000,000 procured under paragraph 8.2.

         (b) Lessee shall pay any such premium increases to Lessor within 30
days after receipt by Lessee of a copy of the premium statement or other
satisfactory evidence of the amount due. If the insurance policies maintained
hereunder cover other improvements in addition the Premises, Lessor shall also
deliver to Lessee a statement of the amount of such increase attributable to the
Premises and showing in reasonable detail, the manner in which such amount was
computed. If the term of this Lease shall not expire concurrently with the
expiration of the period covered by such insurance, Lessee's liability for
premium increases shall be prorated on an annual basis.

         (c) If the Premises are part of a larger building, then Lessee shall
not be responsible for paying any increase in the property insurance premium
caused by the acts or omissions of any other tenant of the building of which the
Premises are a part.


                                      -4-
<PAGE>

         8.5 INSURANCE POLICIES. Insurance required hereunder shall be in
companies holding a "General Policyholders Rating" of at least B plus, or such
other rating as may be required by a lender having a lien on the Premises, as
set forth in the most current issue of "Best's Insurance Guide" Lessee shall
deliver to Lessor copies of policies of liability insurance required under
Paragraph 8.1 or certificates evidencing the existence and amounts of such
insurance. No such policy shall be cancellable or subject to reduction of
coverage or other modification except after thirty (30) days' prior written
notice to Lessor. Lessee shall, at least thirty (30) days prior to the
expiration of such policies, furnish Lessor with renewals or days' prior written
notice to Lessor. Lessees shall, at thirty (30) days prior to the expiration of
such policies, furnish Lessor with renewals or "binders" thereof, or Lessor may
order such insurance and charge the cost thereof to Lessee, which amount shall
be payable by Lessee upon demand. Lessee shall not do or permit to be done
anything which shall invalidate the insurance policies referred to in Paragraph
8.3.

         8.6 WAIVER OF SUBROGATION. Lessee and Lessor each hereby release and
relieve the other, and waive their entire right of recovery against the other
for loss or damage arising out of or incident to the perils insured against
_______ paragraph 8.3, which perils occur in, on or about the Premises, whether
due to the negligence of_______________ and/or_________________ Lessee and
Lessor shall, upon obtaining the policies of insurance required hereunder,
give notice to the insurance carrier or carriers that the foregoing mutual
waiver of subrogation is contained in this Lease.

         8.7 INDEMNITY. Lessee shall indemnify and hold harmless Lessor from and
against any and all claims arising from Lessee's use of the Premises, or from
the conduct of Lessee's business or from any activity, work or things done,
permitted or suffered by Lessee in or about the Premises or elsewhere and shall
further indemnify and hold harmless Lessor from and against any and all claims
arising from any breach of default in the performance of any obligation on
Lessee's part to be performed under the terms of this Lease, or arising from any
negligence of the Lessee, or any of Lessee's agents, contractors, or employees,
and from and against all costs, attorney's fees, expenses and liabilities
incurred in the defense of any such claim or any action or proceeding brought
thereon, and in case any action or proceeding be brought against Lessor by
reason of any such claim, Lessee upon notice from Lessor shall defend the same
at Lessee's expense by counsel satisfactory to Lessor. Lessee, as a material
part of the consideration to Lessor, hereby assumes all risk of damage to
property or injury to persons, in, upon or about the Premises arising from any
cause and Lessee hereby waives all claims in respect thereof against Lessor,
excluding damages caused by negligence of Lessor.

         8.8 EXEMPTION OF LESSOR FROM LIABILITY. Lessee hereby agrees that
Lessor shall not be liable for injury to Lessee's business or any loss of income
therefrom or for damage to the goods, wares, merchandise or other property of
Lessee. Lessee's employees, invitees, customers, or any other person in or about
the Premises, nor shall Lessor be liability for injury to the person of Lessee.
Lessee's employees, agents or contractors, whether such damage or injury is
caused by or results from fire, steam, electricity, gas, water or rain, or from
the breakage, leakage, obstruction or other defects of pipes, sprinklers, wires,
appliances, plumbing, air conditioning or lighting fixtures, or from any other
cause, whether the said damage or injury results from conditions arising upon
the Premises or upon other portions of the building of which the Premises are a
part, or from other sources or places and regardless of whether the cause of
such damage or injury or the means of repairing the same is inaccessible to
Lessee. Lessor shall not be liable for any damages arising from any act or
neglect of any other tenant, if any, of the building in which the Premises are
located.

9. DAMAGE OR DESTRUCTION.

         9.1 DEFINITIONS.

         (a) "Premises Partial Damage" shall herein mean damage or destruction
to the Premises to the extent that the cost of repair is less than 50% of the
fair market value of the Premises immediately prior to such damage or
destruction. "Premises Building Partial Damage" shall herein mean damage or
destruction to the building of which the Premises are a part to the extent that
the cost of repair is less than 50% of the fair market value of such building as
a whole immediately prior to such damage or destruction.

         (b) "Premises Total Destruction" shall herein mean damage or
destruction to the Premises to the extent that the total cost of repair is 50%
or more of the fair market value of the Premises immediately prior to such
damage or destruction. "Premises Building Total Destruction" shall herein mean
damage or destruction to the building of which the Premises are a part to the
extent that the cost of repair is 50% or more of the fair market value of such
building as a whole immediately prior to such damage or destruction.


                                      -5-
<PAGE>

         (c) "Insured Loss" shall herein mean damage or destruction which was
caused by an event required to be covered by the insurance described in
paragraph 8.

         9.2 PARTIAL DAMAGE -- INSURED LOSS. Subject to the provisions of
paragraphs 9.4, 9.5 and 9.6, if at any time during the term of this Lease there
is damage which is an Insured Loss and which falls into the classification of
Premises Partial Damage or Premises Building Partial Damage, then Lessor shall,
at Lessor's sole cost, repair such damage, but not Lessee's fixtures, equipment
or tenant improvements, as soon as reasonably possible and this Lease shall
continue in full force and effect.

         9.3 PARTIAL DAMAGE -- UNINSURED LOSS. Subject to the provisions of
paragraphs 9.4, 9.5 and 9.6, if at any time during the term of this Lease there
is damage which is not an Insured Loss and which falls within the classification
of Premises Partial Damage or Premises Building Partial Damage, unless caused by
a negligent or willful act of Lessee (in which event Lessee shall make the
repairs at Lessee's expense), Lessor may at Lessor's option either (i) repair
such damage as soon as reasonably possible at Lessor's expense, in which event
this Lease shall continue in full force and effect, or (ii) give written notice
to Lessee within thirty (30) days after the date of the occurrence of such
damage of Lessor's intention to cancel and terminate this Lease, as of the date
of the occurrence of such damage. In the event Lessor elects to give such notice
of Lessee's intention to cancel and terminate this Lease. Lessee shall have the
right within ten (10) days after the receipt of such notice to give written
notice to Lessor of Lessee's intention to repair such damage at Lessee's
expense, without reimbursement from Lessor, in which event this Lease shall
continue in full force and effect, and Lessee shall proceed to make such repairs
as soon as reasonably possible. If Lessee does not give such notice within such
10-day period this Lease shall be cancelled and terminated as of the date of the
occurrence of such damage.

         9.4 TOTAL DESTRUCTION. If at any time during the term of this Lease
there is damage, whether or not an Insured Loss, (including destruction required
by any authorized public authority), which falls into the classification of
Premises Total Destruction or Premises Building Total Destruction, this Lease
shall automatically terminate as of the date of such total destruction.

         9.5  DAMAGE NEAR END OF TERM.

         (a) If at any time during the last six months of the term of this Lease
there is damage, whether or not an Insured Loss, which falls within the
classification of Premises Partial Damage, Lessor may at Lessor's option cancel
and terminate this Lease as of the date of occurrence of such damage by giving
written notice to Lessee of Lessor's election to do so within 30 days after the
date of occurrence of such damage in excess of $20,000.

         (b) Notwithstanding paragraph 9.5(a), in the event that Lessee has an
option to extend or renew this Lease, and the time within which said option may
be exercised has not yet expired, Lessee shall exercise such option, if it is to
be exercised at all, no later than 20 days after the occurrence of an Insured
Loss falling within the classification of Premises Partial Damage during the
last six months of the term of this Lease. If Lessee duly exercises such option
during said 20 day period, Lessor shall, at Lessor's expense, repair such damage
as soon as reasonably possible and this Lease shall continue in full force and
effect. If Lessee fails to exercise such option during said 20 day period, then
Lessor may at Lessor's option terminate and cancel this Lease as of the
expiration of said 20 day period by giving written notice to Lessee of Lessor's
election to do so within 10 days after the expiration of said 20 day period,
notwithstanding any term or provision in the grant of option to the contrary.

         9.6  ABATEMENT OF RENT; LESSEE'S REMEDIES.

         (a) In the event of damage described in paragraphs 9.2 or 9.3, and
Lessor or Lessee repairs or restores the Premises pursuant to the provisions of
this Paragraph 9, the rent payable hereunder for the period during which such
damage, repair or restoration continues shall be abated in proportion to the
degree to which Lessee's use of the Premises is impaired. Except for abatement
of rent, if any, Lessee shall have no claim against Lessor for any damage
suffered by reason of any such damage, destruction, repair or restoration,
except damage caused by Lessor.

         (b) If Lessor shall be obligated to repair or restore the Premises
under the provisions of this Paragraph 9 and shall not commence such repair or
restoration within 90 days after such obligations shall accrue, Lessee may at
Lessee's option cancel and terminate this Lease by giving Lessor written notice
of Lessee's election to do so at any time prior to the commencement of such
repair or restoration. In such event this Lease shall terminate as of the date
of such notice.

         9.7 TERMINATION -- ADVANCE PAYMENTs. Upon termination of this Lease
pursuant to this Paragraph 9, an equitable adjustment shall be made concerning
advance rent and any advance payments made by Lessee to Lessor.



                                      -6-
<PAGE>

Lessor shall, in addition, return to Lessee so much of Lessee's security deposit
as has not theretofore been applied by Lessor.

         9.8 WAIVER. Lessor and Lessee waive the provisions of any statutes
which relate to termination of leases when leased property is destroyed and
agree that such event shall be governed by the terms of this Lease.

10.  REAL PROPERTY TAXES.

         10.1 PAYMENT OF TAX INCREASE. Lessor shall pay the real property tax,
as defined in paragraph 10.3, applicable to the Premises; provided, however,
that Lessee shall pay, in addition to rent, the amount, if any, by which real
property taxes applicable to the Premises increase over the fiscal real estate
tax year 1998, 1999. Such payment shall be made by Lessee within thirty (30)
days after receipt of Lessor's written statement setting forth the amount of
such increase and the computation thereof. if the term of this Lease shall not
expire concurrently with the expiration of the tax fiscal year, Lessee's
liability for increased taxes for the last partial lease year shall be prorated
on an annual basis.

         10.2 ADDITIONAL IMPROVEMENTS. Notwithstanding paragraph 10.1 hereof,
Lessee shall pay to Lessor upon demand therefor the entirety of any increase in
real property tax if assessed solely by reason of additional improvements placed
upon the Premises by Lessee or at Lessee's request.

         10.3 DEFINITION OF "REAL PROPERTY TAX". As used herein, the term "real
property tax" shall include any form of real estate tax or assessment, general,
special, ordinary or extraordinary, and any license fee, commercial rental tax,
improvement bond or bonds, levy or tax (other than inheritance, personal income
or estate taxes) imposed on the Premises by any authority having the direct or
indirect power to tax, including any city, state or federal government, or any
school, agricultural, sanitary, fire, street, drainage or other improvement
district thereof, as against any legal or equitable interest of Lessor in the
Premises or in the real property of which the Premises are a part, as against
Lessor's right to rent or other income therefrom, and as against Lessor's
business of leasing the Premises. The term "real property tax" shall also
include any tax, fee, levy, assessment or charge (i) in substitution of,
partially or totally, any tax, fee, levy, assessment or charge hereinabove
included within the definition of "real property tax," or (ii) the nature of
which was hereinbefore included within the definition of "real property tax," or
(iii) which is imposed for a service or right not charged prior to June 1, 1978,
or, if previously charged, has been increased since June 1, 1978, or (iv) which
is imposed as a result of a transfer, either partial or total, of Lessor's
interest in the Premises or which is added to a tax or charge hereinbefore
included within the definition of real property tax by reason of such transfer,
or (v) which is imposed by reason of this transaction, any modifications or
changes hereto, or any transfers hereof.

         10.4 JOINT ASSESSMENT. If the Premises are not separately assessed,
Lessee's liability shall be an equitable proportion of the real property taxes
for all of the land and improvements included within the tax parcel assessed,
such proportion to be determined by Lessor from the respective valuations
assigned in the assessor's work sheets or such other information as may be
reasonably available. Lessor's reasonable determination thereof, in good faith,
shall be conclusive.

         10.5  PERSONAL PROPERTY TAXES.

         (a) Lessee shall pay prior to delinquency all taxes assessed against
and levied upon trade fixtures, furnishings, equipment and all other personal
property of Lessee contained in the Premises or elsewhere. When possible, Lessee
shall cause said trade fixtures, furnishings, equipment and all other personal
property to be assessed and billed separately from the real property of Lessor.

         (b) If any of Lessee's said personal property shall be assessed with
Lessor's real property, Lessee shall pay Lessor the taxes attributable to Lessee
within 10 days after receipt of a written statement setting forth the taxes
applicable to Lessee's property.

11. UTILITIES. Lessee shall pay for all water, gas, heat, light, power,
telephone and other utilities and services supplied to the Premises, together
with any taxes thereon. If any such services are not separately metered to
Lessee, Lessee shall pay a reasonable proportion to be determined by Lessor of
all charges jointly metered with other premises.

12.  ASSIGNMENT AND SUBLETTING.

         12.1 LESSOR'S CONSENT REQUIRED. Lessee shall not voluntarily or by
operation of law assign, transfer, mortgage, sublet, or otherwise transfer or
encumber all or any part of Lessee's interest in this Lease or in the



                                      -7-
<PAGE>

Premises, without Lessor's prior written consent, which Lessor shall not
unreasonably withhold. Lessor shall respond to Lessee's request for consent
hereunder in a timely manner and any attempted assignment, transfer, mortgage,
encumbrance or subletting without such consent shall be void, and shall
constitute a breach of this Lease.

         12.2 LESSEE AFFILIATE. Notwithstanding the provisions of paragraph 12.1
hereof, Lessee may assign or sublet the Premises, or any portion thereof,
without Lessor's consent, to any corporation which controls, is controlled by or
is under common control with Lessee, or to any corporation resulting from the
merger or consolidation with Lessee, or to any person or entity which acquires
all the assets of Lessee as a going concern of the business that is being
conducted on the Premises, provided that said assignee assumes, in full, the
obligations of Lessee under this Lease. Any such assignment shall not, in any
way, affect or limit the liability of Lessee under the terms of this Lease even
if after such assignment or subletting the terms of this Lease are materially
changed or altered without the consent of Lessee, the consent of whom shall not
be necessary.

         12.3 NO RELEASE OF LESSEE. Regardless of Lessor's consent, no
subletting or assignment shall release Lessee of Lessee's obligation or alter
the primary liability of Lessee to pay the rent and to perform all other
obligations to be performed by Lessee hereunder. The acceptance of rent by
Lessor from any other person shall not be deemed to be a waiver by Lessor of any
provision hereof. Consent to one assignment or subletting shall not be deemed
consent to any subsequent assignment or subletting. In the event of default by
any assignee of Lessee or any successor of Lessee, in the performance of any of
the terms hereof, Lessor may proceed directly against Lessee without the
necessity of exhausting remedies against said assignee. Lessor may consent to
subsequent assignments or subletting of this Lease or amendments or
modifications to this Lease with assignees of Lessee, without notifying Lessee,
or any successor of Lessee, and without obtaining its or their consent thereto
and such action shall not relieve Lessee of liability under this Lease.

         12.4 ATTORNEY'S FEES. In the event Lessee shall assign or sublet the
Premises or request the consent of Lessor to any assignment or subletting or if
Lessee shall request the consent of Lessor for any act Lessee proposes to do
then Lessee shall pay Lessor's reasonable attorneys fees incurred in connection
therewith, such attorneys fees not to exceed $350.00 for each such request.

13. DEFAULTS; REMEDIES.

         13.1 DEFAULTS. The occurrence of any one or more of the following
events shall constitute a material default and breach of this Lease by Lessee:

         (a) The vacating or abandonment of the Premises by Lessee.

         (b) The failure by Lessee to make any payment of rent or any other
payment required to be made by Lessee hereunder, as and when due where such
failure shall continue for a period of three days after written notice thereof
from Lessor to Lessee. In the event that Lessor serves Lessee with a Notice to
Pay Rent or Quit pursuant to applicable Unlawful Detainer statutes such Notice
to Pay Rent or Quit shall also constitute the notice required by this
subparagraph.

         (c) The failure by Lessee to observe or perform any of the covenants,
conditions or provisions of this Lease to be observed or performed by Lessee,
other than described in paragraph (b) above, where such failure shall continue
for a period of 30 days after written notice thereof from Lessor to Lessee;
provided, however, that if the nature of Lessee default is such that more than
30 days are reasonably required for its cure, then Lessee shall not be deemed to
be in default if Lessee commenced such cure within said 30-day period and
thereafter diligently prosecutes such cure to completion.

         (d) (i) The making by Lessee of any general arrangement or assignment
for the benefit or creditors; (ii) Lessee becomes a debtor as defined in 11
U.S.C. Section 101 or any successor statute thereto (unless, in the case of a
petition filed against Lessee, the same is dismissed within 60 days), (iii) the
appointment of a trustee or receiver to take possession of substantially all of
Lessee's assets located at the Premises or of Lessee's interest in this Lease,
where possession is not restored to Lessee within 30 days; or (iv) the
attachment, execution or other judicial seizure of substantially all of Lessee's
assets located at the Premises or of Lessee's interest in this Lease, where such
seizure is not discharged within 30 days. Provided, however, in the event that
any provision of this paragraph 13.1(d) is contrary to any applicable law, such
provision shall be of no force or effect.

         (e) The discovery by Lessor that any financial statement given to
Lessor by Lessee, any assignee of Lessee, any subtenant of Lessee, any successor
in interest of Lessee or any guarantor of Lessee's obligation hereunder, and any
of them, was materially false.


                                      -8-
<PAGE>

         13.2 REMEDIES. In the event of any such material default or breach by
Lessee, Lessor may at any time thereafter, with or without notice or demand and
without limiting Lessor in the exercise of any right or remedy which Lessor may
have by reason of such default or breach.

         (a) Terminate Lessee's right to possession of the Premises by any
lawful means, in which case this Lease shall terminate and Lessee shall
immediately surrender possession of the Premises to Lessor. In such event Lessor
shall be entitled to recover from Lessee all damages incurred by Lessor by
reason of Lessee's default including, but not limited to, the cost of recovering
possession of the Premises; expenses of reletting, including necessary
renovation and alteration of the Premises, reasonable attorney's fees, and any
real estate commission actually paid; the worth at the time of award by the
court having jurisdiction thereof of the amount by which the unpaid rent for the
balance of the term after the time of such award exceeds the amount of such
rental loss from the same period that Lessee proves could be reasonably avoided;
that portion of the leasing commission paid by Lessor pursuant to Paragraph 15
applicable to the unexpired term of this Lease.

         (b) Maintain Lessee's right to possession in which case this Lease
shall continue in effect whether or not Lessee shall have abandoned the
Premises. In such event Lessor shall be entitled to enforce all of Lessor's
rights and remedies under this Lease, including the right to recover the rent as
it becomes due hereunder.

         (c) Pursue any other remedy now or hereafter available to Lessor under
the laws or judicial decisions of the state wherein the Premises are located.
Unpaid installments of rent and other unpaid monetary obligations of Lessee
under the terms of this Lease shall bear interest from the date due at the
maximum rate then allowable by law.

         13.3 DEFAULT BY LESSOR. Lessor shall not be in default unless Lessor
fails to perform obligations required of Lessor within a reasonable time, but in
no event later than thirty (30) days after written notice by Lessee to Lessor
and to the holder of any first mortgage or deed of trust covering the Premises
whose name and address shall have theretofore been furnished to Lessee in
writing, specifying wherein Lessor has failed to perform such obligation;
provided, however, that if the nature of Lessor's obligation is such that more
than thirty (30) days are required for performance then Lessor shall not be in
default if Lessor commences performance within such 30-day period and thereafter
diligently prosecutes the same to completion.

         13.4 LATE CHARGES. Lessee hereby acknowledges that late payment by
Lessee to Lessor of rent and other sums due hereunder will cause Lessor to incur
costs not contemplated by this Lease, the exact amount of which will be
extremely difficult to ascertain. Such costs include, but are not limited to,
processing and accounting charges, and late charges which may be imposed on
Lessor by the terms of any mortgage or trust deed covering the Premises.
Accordingly, if any installment of rent or any other sum due from Lessee shall
not be recovered by Lessor or Lessor's designee within ten (10) days after such
amount shall be due, then, without any requirement for notice to Lessee, Lessee
shall pay to Lessor a late charge equal to 6% of such overdue amount. The
parties hereby agree that such late charge represents a fair and reasonable
estimate of the costs Lessor will incur by reason of late payment by Lessee.
Acceptance of such late charge by Lessor shall in no event constitute a waiver
of Lessee's default with respect to such overdue amount, nor prevent Lessor from
exercising any of the other rights and remedies granted hereunder. In the event
that a late charge is payable hereunder, whether or not collected, for three (3)
consecutive installments of rent, then rent shall automatically become due and
payable quarterly in advance, rather than monthly, notwithstanding paragraph 4
or any other provision of this Lease to the contrary.

         13.5 IMPOUNDS. In the event that a late charge is payable hereunder,
whether or not collected, for three (3) installments of rent or any other
monetary obligation of Lessee under the terms of this Lease, Lessee shall pay to
Lessor, if Lessor shall so request, in addition to any other payments required
under this Lease, a monthly advance installment, payable at the same time as the
monthly rent, as estimated by Lessor, for real property tax and insurance
expenses on the Premises which are payable by Lessee under the terms of this
Lease. Such fund shall be established to insure payment when due, before
delinquency, of any or all such real property taxes and insurance premiums. If
the amounts paid to Lessor by Lessee under the provisions of this paragraph are
insufficient to discharge the obligations of Lessee to pay such real property
taxes and insurance premiums as the same become due, Lessee shall pay to Lessor,
upon Lessor's demand, such additional sums necessary to pay such obligations.
All moneys paid to Lessor under this paragraph may be intermingled with other
moneys of Lessor and shall not bear interest. In the event of a default in the
obligations of Lessee to perform under this Lease, then any balance remaining
from funds paid to Lessor under the provisions of this paragraph may, at the
option of Lessor, be applied to the payment of any monetary default of Lessee in
lieu of being applied to the payment of real property tax and insurance
premiums.


                                      -9-
<PAGE>

14. CONDEMNATION. If the Premises or any portion thereof are taken under the
power of eminent domain, or sold under the threat of the exercise of said power
(all of which are herein called "condemnation"), this Lease shall terminate as
to the part so taken as of the date the condemning authority takes title or
possession, whichever first occurs. If more than 10% of the floor area of the
building on the Premises, or more than 25% of the land area of the Premises
which is not occupied by any building, is taken by condemnation, Lessee may, at
Lessee's option, to be exercised in writing only within ten (10) days after
Lessor shall have given Lessee written notice of such taking (or in the absence
of such notice, within ten (10) days after the condemning authority shall have
taken possession) terminate this Lease as of the date the condemning authority
takes such possession. If Lessee does not terminate this Lease in accordance
with the foregoing, this Lease shall remain in full force and effect as the
portion of the Premises remaining, except that the rent shall be reduced in the
proportion that the floor area of the building taken bears to the total floor
area of the building situated on the Premises. No reduction of rent shall occur
if the only area taken is that which does not have a building located thereon.
Any award for the taking of all or any part of the Premises under the power of
eminent domain or any payment made under the threat of the exercise of such
power shall be the property of Lessor, whether such award shall be made as
compensation for diminution in value of the leasehold or for the taking of the
fee, or as severance damages; provided, however, that Lessee shall be entitled
to any award for loss of or damage to Lessee's trade fixtures and removable
personal property. In the event that this Lease is not terminated by reason of
such condemnation, Lessor shall to the extent of severance damages received by
Lessor in connection with such condemnation, repair any damage to the Premises
caused by such condemnation except to the extent that Lessee has been reimbursed
therefor by the condemning authority. Lessee shall pay any amount in excess of
such severance damages required to complete such repair.

15. BROKER'S FEE.

         (a) Upon execution of this Lease by both parties, Lessor shall pay to
Cornish & Carey Commercial per Cornish and Carey's gross lease schedule as
historically used with Westlake Development Company.

         (b) Lessor further agrees that if Lessee exercises any Option as
defined in paragraph 39 of this Lease which is granted to Lessee under this
Lease, or any subsequently granted option which is substantially similar to the
Option granted to Lessee with this Lease, or if Lessee acquires any rights to
the Premises or other premises described in this Lease which are substantially
similar to ____________________ an Option herein granted to Lessee been
exercised, or if Lessee remains in possession of the Premises after the
expiration of the term of this Lease after having failed to exercise an Option,
or if said broker(s) are the procuring cause of any other lease or sale entered
into between the parties pertaining to the Premises and/or any adjacent property
in which Lessor has an interest, then as to any of said transactions, Lessor
shall pay said broker(s) a fee in accordance with the schedule of said broker(s)
in effect at the time of execution of this Lease.

         (c) Lessor agrees to pay said fee not only on behalf of Lessor but also
on behalf of any person, corporation, association, or other entity having an
ownership interest in said real property or any part thereof, when such fee is
due hereunder. Any transferee of Lessor's interest in this Lease, whether such
transfer is by agreement or by operation of law, shall be deemed to have assumed
Lessor's obligation under this Paragraph 15. Said broker shall be a third party
beneficiary of the provisions of this Paragraph 15.

16. ESTOPPEL CERTIFICATE

         (a) Lessee shall at any time upon not less than ten (10) days' prior
written notice from Lessor execute, acknowledge and deliver to Lessor a
statement in writing (i) certifying that this Lease is unmodified and in full
force and effect (or, if modified, stating the nature of such modification and
certifying that this Lease, as so modified, is in full force and effect) and the
date to which the rent and other charges are paid in advance, if any, and (ii)
acknowledging that there are not, to Lessee's knowledge, any uncured defaults on
the part of Lessor hereunder, or specifying such defaults if any are claimed.
Any such statement may be conclusively relied upon by any prospective purchaser
or encumbrancer of the Premises.

         (b) At Lessor's option, Lessee's failure to deliver such statement
within such time shall be a material breach of this Lease or shall be conclusive
upon Lessee (i) that this Lease is in full force and effect, without
modification except as may be represented by Lessor, (ii) that there are no
uncured defaults in Lessor's performance and (iii) that not more than one
month's rent has been paid in advance or such failure may be considered by
Lessor as a default by Lessee under this Lease.


                                      -10-
<PAGE>

         (c) If Lessor desires to finance, refinance, or sell the Premises, or
any part thereof, Lessee hereby agrees to deliver to any lender or purchaser
designated by Lessor such financial statements of Lessee as may be reasonably
required by such lender or purchaser. Such statements ____________ include the
past three years financial statements of Lessee. All such financial statements
shall be received by Lessor and such lender or purchaser in confidence and shall
be used only for the purposes herein set forth.

17. LESSOR'S LIABILITY. The term "Lessor" as used herein shall mean only the
owner or owners at the time in question of the fee, title or a Lessee's interest
in a ground lease of the Premises, and except as expressly provided in Paragraph
15, in the event of any transfer of such title or interest. Lessor herein named
(and in case of any subsequent transfers then the grantor) shall be relieved
from and after the date of such transfer of all liability as respects Lessor's
obligations thereafter to be performed, provided that any funds in the hands of
Lessor or the then grantor at the time of such transfer, in which Lessee has an
interest, shall be delivered to the grantee. The obligations contained in this
Lease to be performed by Lessor shall, subject as aforesaid, be binding on
Lessor's successors and assigns, only during their respective periods of
ownership.

18. SEVERABILITY. The invalidity of any provision of this Lease as determined by
a court of competent jurisdiction, shall in no way affect the validity of any
other provision hereof.

19. INTEREST ON PAST-DUE OBLIGATIONS. Except as expressly herein provided, any
amount due to Lessor not paid when due shall bear interest at the maximum rate
then allowable by law from the date due. Payment of such interest shall not
excuse or cure any default by Lessee under this Lease, provided, however, that
interest shall not be payable on late charges incurred by Lessee nor on any
amounts upon which late charges are paid by Lessee.

20. TIME OF ESSENCE. Time is of the essence.

21. ADDITIONAL RENT. Any monetary obligations of Lessee to Lessor under the
terms of this Lease shall be deemed to be rent.

22. INCORPORATION OF PRIOR AGREEMENTS; AMENDMENTS. This Lease contains all
agreements of the parties with respect to any matter mentioned herein. No prior
agreement or understanding pertaining to any such matter shall be effective.
This Lease may be modified in writing only, signed by the parties in interest at
the time of the modification. Except as otherwise stated in this Lease, Lessee
hereby acknowledges that neither the real estate broker listed in Paragraph 15
hereof nor any cooperating broker on this transaction nor the Lessor or any
employees or agents of any of said persons has made any oral or written
warranties or representations to Lessee relative to the condition or use by
Lessee of said Premises and Lessee acknowledges that Lessee assumes all
responsibility regarding the Occupations Safety Health Act, the legal use and
adaptability of the Premises and the compliance thereof with all applicable laws
and regulations in effect during the term of this Lease except as otherwise
specifically stated in this Lease.

23. NOTICES. Any notice required or permitted to be given hereunder shall be in
writing and may be given by personal delivery or by certified mail, and if given
personally or by mail, shall be deemed sufficiently given if addressed to Lessee
or to Lessor at the address noted below the signature of the respective parties,
as the case may be. Either party may by notice to the other specify a different
address for notice purposes except that upon Lessee's taking possession of the
Premises, the Premises shall constitute Lessee's address for notice purposes. A
copy of all notices required or permitted to be given to Lessor hereunder shall
be concurrently transmitted to such party or parties at such addresses as Lessor
may from time to time hereafter designate by notice to Lessee.

24. WAIVERS. No waiver by Lessor or any provision hereof shall be deemed a
waiver of any other provision hereof or of any subsequent breach by Lessee of
the same or any other provision. Lessor's consent to, or approval of any act,
shall not be deemed to render unnecessary the obtaining of Lessor's consent to
or approval of any subsequent act by Lessee. The acceptance of rent hereunder by
Lessor shall not be a waiver of any preceding breach by Lessee of any provision
hereof, other than the failure of Lessee to pay the particular rent so accepted,
regardless of Lessor's knowledge of such preceding breach at the time of
acceptance of such rent.

25. RECORDING. Either Lessor or Lessee shall, upon request of the other,
execute, acknowledge and deliver to the other a "short form" memorandum of this
Lease for recording purposes.

26. HOLDING OVER. If Lessee, with Lessor's consent, remains in possession of the
Premises or any part thereof after the expiration of the term hereof, such
occupancy shall be a tenancy from month to month upon all the provisions of this
Lease pertaining to the obligations of Lessee, but all options and rights of
first refusal, if any, granted under the terms of this Lease shall be deemed
terminated and be of no further effect during said month to month tenancy.


                                      -11-
<PAGE>

27. CUMULATIVE REMEDIES. No remedy or election hereunder shall be deemed
exclusive but shall, wherever possible, be cumulative with all other remedies at
law or in equity.

28. COVENANTS AND CONDITIONS. Each provision of this Lease performable by Lessee
shall be deemed both a covenant and a condition.

29. BINDING EFFECT; CHOICE OF LAW. Subject to any provisions hereof restricting
assignment or subletting by Lessee and subject to the provisions of Paragraph
17, this Lease shall bind the parties, their personal representatives,
successors and assigns. This Lease shall be governed by the laws of the State
wherein the Premises are located.

30. SUBORDINATION.

         (a) This Lease, at Lessor's option, shall be subordinate to any ground
lease, mortgage, deed of trust, or any other hypothecation or security now or
hereafter placed upon the real property of which the Premises are a part and to
any and all advances made on the security thereof and to all renewals,
modifications, consolidations, replacements and extensions thereof.
Notwithstanding such subordination, Lessee's right to quiet possession of the
Premises shall not be disturbed if Lessee is not in default and so long as
Lessee shall pay the rent and observe and perform all of the provisions of this
Lease, unless this Lease is otherwise terminated pursuant to its terms. If any
mortgagee, trustee or ground lessor shall elect to have this Lease prior to the
lien of its mortgage, deed of trust or ground lease, and shall give written
notice thereof to Lessee, this Lease shall be deemed prior to such mortgage,
deed of trust, or ground lease, whether this Lease is dated prior or subsequent
to the date of said mortgage, deed of trust or ground lease or the date of
recording thereof.

         (b) Lessee agrees to execute any documents required to effectuate an
attornment, a subordination or to make this Lease prior to the lien of any
mortgage, deed of trust or ground lease, as the case may be. Lessee's failure to
execute such documents within 10 days after written demand shall constitute a
material default by Lessee hereunder, or, at Lessor's option, Lessor shall
execute such documents on behalf of Lessee as Lessee's attorney-in-fact. Lessee
does hereby make, constitute and irrevocably appoint Lessor as Lessee's
attorney-in-fact and in Lessee's name, place and stead, to execute such
documents in accordance with this paragraph 30(b).

31. ATTORNEY'S FEES. If either party or the broker named herein brings an action
to enforce the terms hereof or declare rights hereunder, the prevailing party in
any such action, on trial or appeal, shall be entitled to his reasonable
attorney's fees to be paid by the losing party as fixed by the court. The
provisions of this paragraph shall inure to the benefit of the broker named
herein who seeks to enforce a right hereunder.

32. LESSOR'S ACCESS. Lessor and Lessor's agents shall have the right to enter
the Premises at reasonable times for the purpose of inspecting the same, showing
the same to prospective purchasers, lenders, or lessees, and making such
alterations, repairs, improvements or additions to the Premises or to the
building of which they are a part as Lessor may deem necessary or desirable.
Lessor may at any time place on or about the Premises any ordinary "For Sale"
signs and Lessor may at any time during the last 120 days of the term hereof
place on or about the Premises any ordinary "For Lease" signs, all without
rebate of rent or liability to Lessee.

33. AUCTIONS. Lessee shall not conduct, nor permit to be conducted, either
voluntarily or involuntarily, any auction upon the Premises without first having
obtained Lessor's prior written consent. Notwithstanding anything to the
contrary in this Lease, Lessor shall not be obligated to exercise any standard
of reasonableness in determining whether to grant such consent.

34. SIGNS. Lessee shall not place any sign upon the Premises without Lessor's
prior written consent except that Lessee shall have the right, without the prior
permission of Lessor to place ordinary and usual for rent or sublet signs
thereon.

35. MERGER. The voluntary or other surrender of this Lease by Lessee, or a
mutual cancellation thereof, or a termination by Lessor, shall not work a
merger, and shall, at the option of Lessor, terminate all or any existing
subtenancies or may, at the option of Lessor, operate as an assignment to Lessor
of any or all of such subtenancies.

36. CONSENTS. Except for paragraph 33 hereof, wherever in this Lease the consent
of one party is required to an act of the other party, such consent shall not be
unreasonably withheld.

37. GUARANTOR. In the event that there is a guarantor of this Lease, said
guarantor shall have the same obligations as Lessee under this Lease.


                                      -12-
<PAGE>

38. QUIET POSSESSION. Upon Lessee paying the rent for the Premises and observing
and performing all of the covenants, conditions and provisions on Lessee's part
to be observed and performed hereunder., Lessee shall have quiet possession of
the Premises for the entire term hereof subject to all of the provisions of this
Lease. The individuals executing this Lease on behalf of Lessor represent and
warrant to Lessee that they are fully authorized and legally capable of
executing this Lease on behalf of Lessor and that such execution is binding upon
all parties holding an ownership interest in the Premises.

39. OPTIONS.

         39.1 DEFINITION. As used in this paragraph the word "Options" has the
following meaning: (1) the right or option to extend the term of this Lease or
to renew this Lease or to extend or renew any lease that Lessee has on other
property of Lessor; (2) the option or right of first refusal to lease the
Premises or the right of first offer to lease the Premises or the right of first
refusal to lease other property of Lessor or the right to first offer to lease
other property of Lessor; (3) the right or option to purchase the Premises, or
the right of first refusal to purchase the Premises, or the right of first offer
to purchase the Premises or the right or option to purchase other property of
Lessor, or the right of first refusal to purchase other property of Lessor or
the right of first offer to purchase other property of Lessor.

         39.2 OPTIONS PERSONAL. Each Option granted to Lessee in this Lease are
personal to Lessee and may not be exercised or be assigned voluntarily or
involuntarily, by or to any person or entity other than Lessee, provided,
however, the Option may be exercised by or assigned to any Lessee Affiliate as
defined in paragraph 12.2 of this Lease. The Options herein granted to Lessee
are not assignable separate and apart from this Lease.

         39.3 MULTIPLE OPTIONS. In the event that Lessee has any multiple
options to extend or renew this Lease a later option cannot be exercised unless
the prior option to extend or renew this Lease has been so exercised.

         39.4  EFFECT OF DEFAULT ON OPTIONS.

         (a) Lessee shall have not right to exercise an Option, notwithstanding
any provision in the grant of Option to the contrary, (i) during the time
commencing from the date Lessor gives to Lessee a notice of default pursuant to
paragraph 13.1(b) or 13.1(c) and continuing until the default alleged in said
notice of default is cured, or (ii) during the period of time commencing on the
day after a monetary obligation to Lessor is due from Lessee and unpaid (without
any necessity for notice thereof to Lessee) continuing until the obligation is
paid, or (iii) at any time after an event of default described in paragraphs
13.1(a), 13.1(d), or 13.1(e) (without any necessity of Lessor to give notice of
such default to Lessee), or (iv) in the event that Lessor has given to Lessee
three or more notices of default under paragraph 13.1(b), where a late charge
becomes payable under paragraph 13.4 for each of such defaults, or paragraph
13.1(c), whether or not the defaults are cured, during the 12 month period prior
to the time that Lessee intends to exercise the subject Option.

         (b) The period of time within which an Option may be exercised shall
not be extended or enlarged by reason of Lessee's inability to exercise an
Option because of the provisions of paragraph 39.4(a).

         (c) All rights of Lessee under the provisions of an Option shall
terminate and be of no further force or effect, notwithstanding Lessee's due and
timely exercise of the Option, if, after such exercise and during the term of
this Lease, (i) Lessee fails to pay to Lessor a monetary obligation of Lessee
for a period of 30 days after such obligation becomes due (without any necessity
of Lessor to give notice thereof to Lessee) or (ii) Lessee fails to commence to
cure a default specified in paragraph 13.1(c) within 30 days after the date that
Lessor gives notice to Lessee of such default and/or Lessee fails thereafter to
diligently prosecute said cure to completion, or (iii) Lessee commits a default
described in paragraph 13.1(a), 13.1(d) or 13.1(e) (without any necessity of
Lessor to give notice of such default to Lessee), or (iv) Lessor gives to Lessee
three or more notices of default under paragraph 13.1(b), where a late charge
becomes payable under paragraph 13.4 for each such default, or paragraph
13.1(c), whether or not the defaults are cured.

40. MULTIPLE TENANT BUILDING. In the event that the Premises are part of a
larger building or group of buildings then Lessee agrees that it will abide by,
keep and observe all reasonable rules and regulations which Lessor may make from
time to time for the management, safety, care, and cleanliness of the building
and grounds, the parking of vehicles and the preservation of good order therein
as well as for the convenience of other occupants and tenants of the building.
The violations of any such rules and regulations shall be deemed a material
breach of this Lease by Lessee.


                                      -13-
<PAGE>

41. SECURITY MEASURES. Lessee hereby acknowledges that the rental payable to
Lessor hereunder does not include the cost of guard service or other security
measures, and that Lessor shall have no obligation whatsoever to provide same.
Lessee assumes all responsibility for the protection of Lessee, its agents and
invitees from acts of third parties.

42. EASEMENTS. Lessor reserves to itself the right, from time to time, to grant
such easements, rights and dedications that Lessor deems necessary or desirable,
and to cause the recordation of Parcel Maps and restrictions, so long as such
easements, rights, dedications, Maps and restrictions do not unreasonably
interfere with the use of the Premises by Lessee. Lessee shall sign any of the
aforementioned documents upon request of Lessor and failure to do so shall
constitute a material breach of this Lease.

43. PERFORMANCE UNDER PROTEST. If at any time a dispute shall arise as to any
amount or sum of money to be paid by one party to the other under the provisions
hereof, the party against whom the obligation to pay the money is asserted shall
have the right to make payment "under protest" and such payment shall not be
regarded as a voluntary payment, and there shall survive the right on the part
of said party to institute suit for recovery of such sum. If it shall be
adjudged that there was no legal obligation on the part of said party to pay
such sum or any part thereof, said party shall be entitled to recover such sum
or so much thereof as it was not legally required to pay under the provisions of
this Lease.

44. AUTHORITY. If Lessee is a corporation, trust, or general or limited
partnership, each individual executing this Lease on behalf of such entity
represents and warrants that he or she is duly authorized to execute and deliver
this Lease on behalf of said entity. If Lessee is a corporation, trust or
partnership, Lessee shall, within thirty (30) days after execution of this
Lease, deliver to Lessor evidence of such authority satisfactory to Lessor.

45. CONFLICT. Any conflict between the printed provisions of this Lease and the
typewritten or handwritten provisions shall be controlled by the typewritten or
handwritten provisions.

46. ADDENDUM. Attached hereto is an addendum or addenda containing paragraphs 47
through 48 which constitutes a part of this Lease.




LESSOR AND LESSEE HAVE CAREFULLY READ AND REVIEWED THIS LEASE AND EACH TERM AND
PROVISION CONTAINED HEREIN AND, BY EXECUTION OF THIS LEASE, SHOW THEIR INFORMED
AND VOLUNTARY CONSENT THERETO. THE PARTIES HEREBY AGREE THAT, AT THE TIME THIS
LEASE IS EXECUTED, THE TERMS OF THIS LEASE ARE COMMERCIALLY REASONABLE AND
EFFECTUATE THE INTENT AND PURPOSE OF LESSOR AND LESSEE WITH RESPECT TO THE
PREMISES.

         IF THIS LEASE HAS BEEN FILLED IN IT HAS BEEN PREPARED FOR SUBMISSION TO
         YOUR ATTORNEY FOR HIS APPROVAL. NO REPRESENTATION OR RECOMMENDATION IS
         MADE BY THE AMERICAN INDUSTRIAL REAL ESTATE ASSOCIATION OR BY THE REAL
         ESTATE BROKER OR ITS AGENTS OR EMPLOYEES AS TO THE LEGAL SUFFICIENCY,
         LEGAL EFFECT, OR TAX CONSEQUENCES OF THIS LEASE OR THE TRANSACTION
         RELATING THERETO; THE PARTIES SHALL RELY



                                      -14-
<PAGE>

         SOLELY UPON THE ADVICE OF THEIR OWN LEGAL COUNSEL AS TO THE LEGAL AND
         TAX CONSEQUENCES OF THIS LEASE.

THE PARTIES HERETO HAVE EXECUTED THIS LEASE AT THE PLACE ON THE DATES SPECIFIED
IMMEDIATELY ADJACENT TO THEIR RESPECTIVE SIGNATURES.

Executed at                                   WESTLAKE DEVELOPMENT COMPANY, INC.
            ------------------------------    ----------------------------------
on                                            By  /s/ Walter H.Y. Chang
   ---------------------------------------        ------------------------------
Address   520 El Camino Real, 9th Floor       By
        ----------------------------------        ------------------------------
          San Mateo, CA  94402                         "LESSEE" (Corporate seal)
- ------------------------------------------
Executed at                                             TRANSGENOMIC, INC.
           -------------------------------      --------------------------------
on        2036 Concourse Drive                By  /s/ Collin D'Silva
   ---------------------------------------      --------------------------------
Address   San Jose, CA  95131                 By
        ----------------------------------      --------------------------------
                                                       "LESSEE" (Corporate seal)
- ------------------------------------------




                                      -15-
<PAGE>

                                                                   EXHIBIT 10.17


                  C O R N I S H  &  C A R E Y  C O M M E R C I A L

                                  =============
                                       C&C
                                  =============

                       O N C O R I N T E R N A T I O N A L

================================================================================
                            L E A S E  A D D E N D U M
================================================================================


ADDENDUM TO THE LEASE DATED NOVEMBER 1, 1998, BY AND BETWEEN WESTLAKE
DEVELOPMENT COMPANY, INC., LANDLORD, AND TRANSGENOMIC, INC., TENANT, FOR THOSE
PREMISES LOCATED AT 2030 CONCOURSE DRIVE, SAN JOSE, CALIFORNIA.

47.      Base Rent Schedule:

<TABLE>
<CAPTION>

         Dates                                         Rent per Month

<S>      <C>                                           <C>
         11/1/1998 through 10/31/1999                  $7,297.50 per month
         11/1/1999 through 10/31/2000                  $7,560.00 per month
         11/1/2000 through 10/31/2001                  $7,822.50 per month
         11/1/2001 through 05/31/2002                  $8,085.00 per month

</TABLE>

48.      A.   Lessee, at Lessee's sole cost and expense, shall have Lessor's
              permission to install one (1) man door and a double door and
              remove a wall as shown on Exhibit A attached.

         B.   Lessor, at Lessor's sole cost and expense, shall install the
              following items after Lessee completes the work in Item A above:

              1.  Paint the entire inside walls of the premises.

              2.  Install new industrial grade carpet in the rooms that are
                  currently carpeted. Color of carpet to be mutually acceptable
                  to Lessee and Lessor.



LANDLORD:         WESTLAKE DEVELOPMENT COMPANY, INC.

By:      /s/ Walter H. Y. Change               Date:             11/11/98
    -------------------------------------            ---------------------------


TENANT:  TRANSGENOMIC, INC.

By:      /s/ Collin D'Silva                    Date:             11/1/98
    -------------------------------------            ---------------------------

<PAGE>

                                                                   EXHIBIT 10.17


                                    EXHIBIT A

                               [Property Diagram]

<PAGE>

                                                                   EXHIBIT 10.18


                        STANDARD INDUSTRIAL LEASE--GROSS

                   AMERICAN INDUSTRIAL REAL ESTATE ASSOCIATION

1. PARTIES. This Lease dated, for reference purposes only, May 15, 1996, is made
by and between Westlake Development Co., Inc., 520 South El Camino Real, Suite
900, San Mateo, California 94402 (herein called "Lessor") and Interaction
Chromatography Inc., wholly owned subsidiary of Sarasep Inc., 2036 Concourse
Drive, San Jose, California 95131 (herein called "Lessee").

2. PREMISES. Lessor hereby leases to Lessee and Lessee leases from Lessor for
the term, at the rental, and upon all of the conditions set forth herein, that
certain real property situated in the County of Santa Clara, State of California
commonly known as 2032 Concourse Drive, San Jose and described as containing
approximately 9,110 square feet of light industrial space being a part of a
larger building. Said real property including the land and all improvements
therein, is herein called "the Premises".

3. TERM.

     3.1 TERM. The term of this Lease shall be for five (5) years commencing on
June 1, 1997 and ending on May 31, 2002, unless sooner terminated pursuant to
any provision hereof.

     3.2 DELAY IN POSSESSION. Notwithstanding said commencement date, if for any
reason Lessor cannot deliver possession of the Premises to Lessee on said date,
Lessor shall not be subject to any liability therefor, nor shall such failure
affect the validity of this Lease or the obligations of Lessee hereunder or
extend the term hereof, but in such case, Lessee shall not be obligated to pay
rent until possession of the Premises is tendered to Lessee; provided, however,
that if Lessor shall not have delivered possession of the Premises within sixty
(60) days from said commencement date, Lessee may, at Lessee's option, by notice
in writing to Lessor within ten (10) days thereafter, cancel this Lease, in
which event the parties shall be discharged from all obligations hereunder;
provided further, however, that if such written notice of Lessee is not received
by Lessor within said ten (10) day period, Lessee's right to cancel this Lease
hereunder shall terminate and be of no further force or effect.

     3.3 EARLY POSSESSION. If Lessee occupies the Premises prior to said
commencement date, such occupancy shall be subject to all provisions hereof,
such occupancy shall not advance the termination date, and Lessee shall pay rent
for such period at the initial monthly rates set forth below.

*4. RENT. Lessee shall pay to Lessor as rent for the Premises, monthly payments
of $10,476.50, in advance, on the first day of each month in year 1, CPI annual
increase in year 2 to 5, as rent for N/A. *See Rent Schedule in Addendum. Rent
for any period during the term hereof which is for less than one month shall be
a pro rata portion of the monthly installment. Rent shall be payable in lawful
money of the United States to Lessor at the address stated herein or to such
other persons or at such other places as Lessor may designate in writing.

**5. SECURITY DEPOSIT. Lessee shall deposit with Lessor upon execution hereof
$12,750.00 as security for Lessee's faithful performance of Lessee's obligations
hereunder. If Lessee fails to pay rent or other charges due hereunder, or
otherwise defaults with respect to any provision of this Lease, Lessor may use,
apply or retain all or any portion of said deposit for the payment of any rent
or other charge in default or for the payment of any other sum to which Lessor
may become obligated by reason of Lessee's default, or to compensate Lessor for
any loss or damage which Lessor may suffer thereby. If Lessor so uses or applies
all or any portion of said deposit, Lessee shall within ten (10) days after
written demand therefor deposit cash with Lessor in an amount sufficient to
restore said deposit to the full amount hereinabove stated and Lessee's failure
to do so shall be a material breach of this Lease. If the monthly rent shall,
from time to time, increase during the term of this Lease, Lessee shall
thereupon deposit with Lessor additional security deposit so that the amount of
security deposit held by Lessor shall at all times bear the same proportion to
current rent as the original security deposit bears to the original monthly rent
set forth in paragraph 4 hereof. Lessor shall not be required to keep said
deposit separate from its general accounts. If Lessee performs all of Lessee's
obligations hereunder, said deposit, or so much thereof as has not theretofore
been applied by Lessor, shall be returned, without payment of interest or other
increment for its use, to Lessee (or, at Lessor's


- --------
** Security Deposit. Payable $8,464.60 by transfer from Lessee's previous
security deposit with Lessor, and $4,285.40 draft paid upon execution of this
Lease.


<PAGE>

option, to the last assignee, if any, of Lessee's interest hereunder) at the
expiration of the term hereof, and after Lessee has vacated the Premises. No
trust relationship is created herein between Lessor and Lessee with respect to
said Security Deposit.

6. USE.

     6.1 USE. The Premises shall be used and occupied only for manufacturing and
sales of chromatograph products and related legal use or any other use which is
reasonably comparable and for no other purpose.

     6.2 COMPLIANCE WITH LAW.

         (a) Lessor warrants to Lessee that the Premises, in its state existing
on the date that the Lease term commences, but without regard to the use for
which Lessee will use the Premises, does not violate any covenants or
restrictions of record, or any applicable building code, regulation or ordinance
in effect on such Lease term commencement date. In the event it is determined
that this warranty has been violated, then it shall be the obligation of the
Lessor, after written notice from Lessee, to promptly, at Lessor's sole cost and
expense, rectify any such violation. In the event Lessee does not give to Lessor
written notice of the violation of this warranty within six months from the date
that the Lease term commences, the correction of same shall be the obligation of
the Lessee at Lessee's sole cost. The warranty contained in this paragraph
6.2(a) shall be of no force or effect if, prior to the date of this Lease,
Lessee was the owner or occupant of the Premises, and, in such event, Lessee
shall correct any such violation at Lessee's sole costs.

         (b) Except as provided in paragraph 6.2(a), Lessee shall, at Lessee's
expense, comply promptly with all applicable statutes, ordinances, rules,
regulations, orders, covenants and restrictions of record, and requirements in
effect during the term or any part of the term hereof, regulating the use by
Lessee of the Premises. Lessee shall not use nor permit the use of the Premises
in any manner that will tend to create waste or a nuisance or, if there shall be
more than one tenant in the building containing the Premises, shall tend to
disturb such other tenants.

     6.3 CONDITION OF PREMISES.

         (a) Lessor shall deliver the Premises to Lessee clean and free of
debris on Lease commencement date (unless Lessee is already in possession) and
Lessor further warrants to Lessee that the plumbing, lighting, air conditioning,
heating, and loading doors in the Premises shall be in good operating condition
on the Lease commencement date. In the event that it is determined that this
warranty has been violated, then it shall be the obligation of Lessor, after
receipt of written notice from Lessee setting forth with specificity the nature
of the violation, to promptly, at Lessor's sole cost, rectify such violation.
Lessee's failure to give such written notice to Lessor within thirty (30) days
after the Lease commencement date shall cause the conclusive presumption that
Lessor has complied with all of Lessor's obligations hereunder. The warranty
contained in this paragraph 6.3(a) shall be of no force or effect if prior to
the date of this Lease, Lessee was the owner or occupant of the Premises.

         (b) Except as otherwise provided in this Lease, Lessee hereby accepts
the Premises in their condition existing as of the Lease commencement date or
the date that Lessee takes possession of the Premises, whichever is earlier,
subject to all applicable zoning, municipal county and state laws, ordinances
and regulations governing and regulating the use of the Premises, and any
covenants or restrictions of record and accepts this Lease subject thereto and
to all matters disclosed thereby and by an exhibits attached hereto. Lessee
acknowledges that neither Lessor nor Lessor's agent has made any representation
or warranty as to the present or future suitability of the Premises for the
conduct of Lessee's business.

7. MAINTENANCE, REPAIRS AND ALTERATIONS.

     7.1 LESSOR'S OBLIGATIONS. Subject to the provisions of Paragraphs 6, 7.2,
and 9 and except for the damage caused by any negligent or intentional act or
omission of Lessee, Lessee's agents, employees, or invitees in which event
Lessee shall repair the damage, Lessor, at Lessor's expense, shall keep in good
order, condition and repair the foundations, exterior walls and the exterior
roof of the Premises. Lessor shall not, however, be obligated to paint such
exterior, nor shall Lessor be required to maintain the interior surface of
exterior walls, windows, doors or plate glass. Lessor shall have no obligation
to make repairs under this Paragraph 7.1 until a reasonable time after receipt
of written notice of the need for such repairs. Lessee expressly waives the
benefits of any statute now or hereafter in effect which would otherwise afford
Lessee the right to make repairs at Lessor's expense or to terminate this Lease
because of Lessor's failure to keep the Premises in good order, condition and
repair.


                                       2
<PAGE>

     7.2 LESSEE'S OBLIGATIONS.

         (a) Subject to the provisions of Paragraph 6, 7.1 and 9, Lessee, at
Lessee's expense, shall keep in good order, condition and repair the Premises
and every part thereof (whether or not the damaged portion of the Premises or
the means of repairing the same are reasonably or readily accessible to Lessee)
including, without limiting the generality of the foregoing, all plumbing,
heating, air conditioning, (Lessee shall procure and maintain, at Lessee's
expense, an air conditioning system maintenance contract) ventilating,
electrical and lighting facilities and equipment within the Premises, fixtures,
interior walls and interior surface of exterior walls, ceilings, windows, doors,
plate glass, and skylights, located within the Premises, and all landscaping,
driveways, parking lots, fences and signs located in the Premises and all
sidewalks and parkways adjacent to the Premises. Any cost of repairs to outside
common area will be calculated on a pro rata basis due on square footage
occupied.

         (b) If Lessee fails to perform Lessee's obligations under this
Paragraph 7.2 or under any other paragraph of this Lease, Lessor may at Lessor's
option enter upon the Premises after 10 days' prior written notice to Lessee
(except in the case of emergency, in which case no notice shall be required),
perform such obligations on Lessee's behalf and put the Premises in good order,
condition and repair, and the cost thereof together with interest thereon at the
maximum rate then allowable by law shall be due and payable as additional rent
to Lessor together with Lessee's next rental installment.

         (c) On the last day of the term hereof, or on any sooner termination,
Lessee shall surrender the Premises to Lessor in the same condition as received,
ordinary wear and tear excepted, clean and free of debris. Lessee shall repair
any damage to the Premises occasioned by the installation or removal of its
trade fixtures, furnishings and equipment. Notwithstanding anything to the
contrary otherwise stated in this Lease, Lessee shall leave the air lines, power
panels, electrical distribution systems, lighting fixtures, space heaters, air
conditioning, plumbing and fencing on the premises in good operating condition.

     7.3 ALTERATIONS AND ADDITIONS.

         (a) Lessee shall not, without Lessor's prior written consent, make any
alterations, improvements, additions, or Utility Installations in, on or about
the Premises, except for nonstructural alterations not exceeding $5,000 in
cumulative costs during the term of this Lease. In any event, whether or not in
excess of $5,000 in cumulative cost, Lessee shall make no change or alteration
to the exterior of the Premises nor the exterior of the building(s) on the
Premises without Lessor's prior written consent. As used in this Paragraph 7.3
the term "Utility Installation" shall mean carpeting, window coverings, air
lines, power panels, electrical distribution systems, lighting fixtures, space
heaters, air conditioning, plumbing, and fencing. Lessor may require that Lessee
remove any or all of said alterations, improvements, additions or Utility
Installations at the expiration of the term, and restore the Premises to their
prior condition. Lessor may require Lessee to provide Lessor, at Lessee's sole
cost and expense, a lien and completion bond in an amount equal to one and
one-half times the estimated cost of such improvements, to insure Lessor against
any liability for mechanic's and materialmen's liens and to insure completion of
the work. Should Lessee make any alterations, improvements, additions or Utility
Installations without the prior approval of Lessor, Lessor may require that
Lessee remove any or all of the same.

         (b) Any alterations, improvements, additions or Utility Installations
in, or about the Premises that Lessee shall desire to make and which requires
the consent of the Lessor shall be presented to Lessor in written form, with
proposed detailed plans. If Lessor shall give its consent, the consent shall be
deemed conditioned upon Lessee acquiring a permit to do so from appropriate
governmental agencies, the furnishing of a copy thereof to Lessor prior to the
commencement of the work and the compliance by Lessee of all conditions of said
permit in a prompt and expeditious manner.

         (c) Lessee shall pay, when due, all claims for labor or materials
furnished or alleged to have been furnished to or for Lessee at or for use in
the Premises, which claims are or may be secured by any mechanics' or
materialmen's lien against the Premises or any interest therein. Lessee shall
give Lessor not less than ten (10) days' notice prior to the commencement of any
work in the Premises, and Lessor shall have the right to post notices of
non-responsibility in or on the Premises as provided by law. If Lessee shall, in
good faith, contest the validity of any such lien, claim or demand, then Lessee
shall, at its sole expense defend itself and Lessor against the same and shall
pay and satisfy any such adverse judgment that may be rendered thereon before
the enforcement thereof against the Lessor or the Premises, upon the condition
that if Lessor shall require, Lessee shall furnish to Lessor a surety bond
satisfactory to Lessor in an amount equal to such contested lien claim or demand
indemnifying Lessor against liability for the same and holding the Premises free
from the effect of such lien or claim. In addition, Lessor



                                       3
<PAGE>

may require Lessee to pay Lessor's attorneys fees and costs in participating in
such action if Lessor shall decide it is to its best interest to do so.

         (d) Unless Lessor requires their removal, as set forth in Paragraph
7.3(a), all alterations, improvements, additions and Utility Installations
(whether or not such Utility Installations constitute trade fixtures of Lessee),
which may be made on the Premises, shall become the property of Lessor and
remain upon and be surrendered with the Premises at the expiration of the term.
Notwithstanding the provisions of this Paragraph 7.3(d), Lessee's machinery and
equipment, other than that which is affixed to the Premises so that it cannot be
removed without material damage to the Premises, shall remain the property of
Lessee and may be removed by Lessee subject to the provisions of Paragraph
7.2(c).

8. INSURANCE; INDEMNITY.

     8.1 LIABILITY INSURANCE - LESSEE. Lessee shall, at Lessee's expense, obtain
and keep in force during the term of this Lease a policy of Combined Single
Limit Bodily Injury and Property Damage Insurance insuring Lessee and Lessor
against any liability arising out of the use, occupancy or maintenance of the
Premises and all other areas appurtenant thereto. Such insurance shall be in an
amount not less than $500,000 per occurrence. The policy shall insure
performance by Lessee of the indemnity provisions of this Paragraph 8. The
limits of said insurance shall not, however, limit the liability of Lessee
hereunder.

     8.2 LIABILITY INSURANCE - LESSOR. Lessor shall obtain and keep in force
during the term of this Lease a policy of Combined Single Limit Bodily Injury
and Property Damage Insurance, insuring Lessor, but not Lessee, against any
liability arising out of the ownership, use, occupancy or maintenance of the
Premises and all areas appurtenant thereto in an amount not less than $500,000
per occurrence.

     8.3 PROPERTY INSURANCE. Lessor shall obtain and keep in force during the
term of this Lease a policy or policies of insurance covering loss or damage to
the Premises, but not Lessee's fixtures, equipment or tenant improvements in an
amount not to exceed the full replacement value thereof, as the same may exist
from time to time, providing protection against all perils included within the
classification of fire, extended coverage, vandalism, malicious mischief, flood
(in the event same is required by a lender having a lien on the Premises),
special extended perils ("all risk", as such term is used in the insurance
industry) but not plate glass insurance. In addition, the Lessor shall obtain
and keep in force, during the term of this Lease, a policy of rental value
insurance covering a period of one year, with loss payable to Lessor, which
insurance shall also cover all real estate taxes and insurance costs for said
period.

     8.4 PAYMENT OF PREMIUM INCREASE.

         (a) Lessee shall pay to Lessor, during the term hereof, in addition to
the rent, the amount of any increase in premiums for the insurance required
under Paragraphs 8.2 and 8.3 over and above such premiums paid during the Base
Period, as hereinafter defined, whether such premium increase shall be the
result of the nature of Lessee's occupancy, any act or omission of Lessee,
requirements of the holder of a mortgage or deed of trust covering the Premises,
increased valuation of the Premises, or general rate increases. In the event
that the Premises have been occupied previously, the words "Base Period" shall
mean the last twelve months of the prior occupancy. In the event that the
Premises have never been previously occupied, the premiums during the "Base
Period" shall be deemed to be the lowest premiums reasonably obtainable for said
insurance assuming the most nominal use of the Premises. Provided, however, in
lieu of the Base Period, the parties may insert a dollar amount at the end of
this sentence which figure shall be considered as the insurance premium for the
Base Period: $         . In no event, however, shall Lessee be responsible for
any portion of the premium cost attributable to liability insurance coverage in
excess of $1,000,000 procured under paragraph 8.2.

         (b) Lessee shall pay any such premium increases to Lessor within 30
days after receipt by Lessee of a copy of the premium statement or other
satisfactory evidence of the amount due. If the insurance policies maintained
hereunder cover other improvements in addition to the Premises, Lessor shall
also deliver to Lessee a statement of the amount of such increase attributable
to the Premises and showing in reasonable detail, the manner in which such
amount was computed. If the term of this Lease shall not expire concurrently
with the expiration of the period covered by such insurance, Lessee's liability
for premium increases shall be prorated on an annual basis.

         (c) If the Premises are part of a larger building, then Lessee shall
not be responsible for paying any increase in the property insurance premium
caused by the acts or omissions of any other tenant of the building of which the
Premises are a part.


                                       4
<PAGE>

     8.5 INSURANCE POLICIES. Insurance required hereunder shall be in companies
holding a "General Policyholders Rating" of at least B plus or such other rating
as may be required by a lender having a lien on the Premises, as set forth in
the most current issue of "Best's Insurance Guide." Lessee shall deliver to
Lessor copies of policies of liability insurance required under Paragraph 8.1 or
certificates evidencing the existence and amounts of such insurance. No such
policy shall be cancellable or subject to reduction of coverage or other
modification except after thirty (30) days' prior written notice to Lessor.
Lessee shall, at least thirty (30) days prior to the expiration of such
policies, furnish Lessor with renewals or "binders" thereof, or Lessor may order
such insurance and charge the cost thereof to Lessee, which amount shall be
payable by Lessee upon demand. Lessee shall not do or permit to be done anything
which shall invalidate the insurance policies referred to in Paragraph 8.3.

     8.6 WAIVER OF SUBROGATION. Lessee and Lessor each hereby release and
relieve the other, and waive their entire right of recovery against the other
for loss or damage arising out of or incident to the perils insured against
under paragraph 8.3, which perils occur in, on or about the Premises whether due
to the negligence of Lessor or Lessee or their agents, employees, contractors
and/or invitees. Lessee and Lessor shall, upon obtaining the policies of
insurance required hereunder, give notice to the insurance carrier or carriers
that the foregoing mutual waiver of subrogation is contained in this Lease.

     8.7 INDEMNITY. Lessee shall indemnify and hold harmless Lessor from and
against any and all claims arising from Lessee's use of the Premises, or from
the conduct of Lessee's business or from any activity, work or things done,
permitted or suffered by Lessee in or about the Premises or elsewhere and shall
further indemnify and hold harmless Lessor from and against any and all claims
arising from any breach or default in the performance of any obligation on
Lessee's part to be performed under the terms of this Lease, or arising from any
negligence of the Lessee, or any of Lessee's agents, contractors, or employees,
and from and against all costs, attorney's fees, expenses and liabilities
incurred in the defense of any such claim or any action or proceeding brought
thereon; and in case any action or proceeding be brought against Lessor by
reason of any such claim, Lessee upon notice from Lessor shall defend the same
at Lessee's expense by counsel satisfactory to Lessor. Lessee, as a material
part of the consideration to Lessor, hereby assumes all risk of damage to
property or injury to persons, in, upon or about the Premises arising from any
cause and Lessee hereby waives all claims in respect thereof against Lessor,
excluding damages caused by negligence by Lessor.

     8.8 EXEMPTION OF LESSOR FROM LIABILITY. Lessee hereby agrees that Lessor
shall not be liable for injury to Lessee's business or any loss of income
therefrom or for damage to the goods, wares, merchandise or other property of
Lessee, Lessee's employees, invitees, customers, or any other person in or about
the Premises, nor shall Lessor be liable for injury to the person of Lessee,
Lessee's employees, agents or contractors, whether such damage or injury is
caused by or results from fire, steam, electricity, gas, water or rain, or from
the breakage, leakage, obstruction or other defects of pipes, sprinklers, wires,
appliances, plumbing, air conditioning or lighting fixtures, or from any other
cause, whether the said damage or injury results from conditions arising upon
the Premises or upon other portions of the building of which the Premises are a
part, or from other sources or places and regardless of whether the cause of
such damage or injury or the means of repairing the same is inaccessible to
Lessee. Lessor shall not be liable for any damages arising from any act or
neglect of any other tenant, if any, of the building in which the Premises are
located.

9. DAMAGE OR DESTRUCTION.

     9.1 DEFINITIONS.

         (a) "Premises Partial Damage" shall herein mean damage or destruction
to the Premises to the extent that the cost of repair is less than 50% of the
fair market value of the Premises immediately prior to such damage or
destruction. "Premises Building Partial Damage" shall herein mean damage or
destruction to the building of which the Premises are a part to the extent that
the cost of repair, is less than 50% of the fair market value of such building
as a whole immediately prior to such damage or destruction.

         (b) "Premises Total Destruction" shall herein mean damage or
destruction to the Premises to the extent that the cost of repair is 50% or more
of the fair market value of the Premises immediately prior to such damage or
destruction. "Premises Building Total Destruction" shall herein mean damage or
destruction to the building of which the Premises are a part to the extent that
the cost of repair is 50% or more of the fair market value of such building as a
whole immediately prior to such damage or destruction.

         (c) "Insured Loss" shall herein mean damage or destruction which was
caused by an event required to be covered by the insurance described in
paragraph 8.


                                       5
<PAGE>

         9.2 PARTIAL DAMAGE - INSURED LOSS. Subject to the provisions of
paragraphs 9.4, 9.5 and 9.6, if at any time during the term of this Lease there
is damage which is an Insured Loss and which falls into the classification of
Premises Partial Damage or Premises Building Partial Damage, then Lessor shall,
at Lessor's sole cost, repair such damage, but not Lessee's fixtures, equipment
or tenant improvements, as soon as reasonably possible and this Lease shall
continue in full force and effect.

         9.3 PARTIAL DAMAGE - UNINSURED LOSS. Subject to the provisions of
Paragraphs 9.4, 9.5 and 9.6, if at any time during the term of this Lease there
is damage which is not an Insured Loss and which falls within the classification
of Premises Partial Damage or Premises Building Partial Damage, unless caused by
a negligent or willful act of Lessee (in which event Lessee shall make the
repairs at Lessee's expense), Lessor may at Lessor's option either (i) repair
such damage as soon as reasonably possible at Lessor's expense, in which event
this Lease shall continue in full force and effect, or (ii) give written notice
to Lessee within thirty (30) days after the date of the occurrence of such
damage of Lessor's intention to cancel and terminate this Lease, as of the date
of the occurrence of such damage. In the event Lessor elects to give such notice
of Lessor's intention to cancel and terminate this Lease, Lessee shall have the
right within ten (10) days after the receipt of such notice to give written
notice to Lessor of Lessee's intention to repair such damage at Lessee's
expense, without reimbursement from Lessor, in which event this Lease shall
continue in full force and effect, and Lessee shall proceed to make such repairs
as soon as reasonably possible. If Lessee does not give such notice within such
10-day period this Lease shall be cancelled and terminated as of the date of the
occurrence of such damage.

         9.4 TOTAL DESTRUCTION. If at any time during the term of this Lease
there is damage, whether or not an Insured Loss, (including destruction required
by any authorized public authority), which falls into the classification of
Premises Total Destruction or Premises Building Total Destruction, this Lease
shall automatically terminate as of the date of such total destruction.

         9.5  DAMAGE NEAR END OF TERM.

         (a) If at any time during the last six months of the term of this Lease
there is damage, whether or not an Insured Loss, which falls within the
classification of Premises Partial Damage, Lessor may at Lessor's option cancel
and terminate this Lease as of the date of occurrence of such damage by giving
written notice to Lessee of Lessor's election to do so within 30 days after the
date of occurrence of such damage in excess of $20,000.00.

         (b) Notwithstanding paragraph 9.5(a), in the event that Lessee has an
option to extend or renew this Lease, and the time within which said option may
be exercised has not yet expired, Lessee shall exercise such option, if it is to
be exercised at all, no later than 20 days after the occurrence of an Insured
Loss falling within the classification of Premises Partial Damage during the
last six months of the term of this Lease. If Lessee duly exercises such option
during said 20 day period, Lessor shall, at Lessor's expense, repair such damage
as soon as reasonably possible and this Lease shall continue in full force and
effect. If Lessee fails to exercise such option during said 20 day period, then
Lessor may at Lessor's option terminate and cancel this Lease as of the
expiration of said 20 day period by giving written notice to Lessee of Lessor's
election to do so within 10 days after the expiration of said 20 day period,
notwithstanding any term or provision in the grant of option to the contrary.

         9.6  ABATEMENT OF RENT; LESSEE'S REMEDIES.

         (a) In the event of damage described in paragraphs 9.2 or 9.3, and
Lessor or Lessee repairs or restores the Premises pursuant to the provisions of
this Paragraph 9, the rent payable hereunder for the period during which such
damage, repair or restoration continues shall be abated in proportion to the
degree to which Lessee's use of the Premises is impaired. Except for abatement
of rent, if any, Lessee shall have no claim against Lessor for any damage
suffered by reason of any such damage, destruction, repair or restoration except
by damage caused by Lessor.

         (b) If Lessor shall be obligated to repair or restore the Premises
under the provisions of this Paragraph 9 and shall not commence such repair or
restoration within 90 days after such obligations shall accrue, Lessee may at
Lessee's option cancel and terminate this Lease by giving Lessor written notice
of Lessee's election to do so at any time prior to the commencement of such
repair or restoration. In such event this Lease shall terminate as of the date
of such notice.

         9.7 TERMINATION - ADVANCE PAYMENTS. Upon termination of this Lease
pursuant to this Paragraph 9, an equitable adjustment shall be made concerning
advance rent and any advance payments made by Lessee to Lessor.



                                       6
<PAGE>

Lessor shall, in addition, return to Lessee so much of Lessee's security deposit
as has not theretofore been applied by Lessor.

         9.8 WAIVER. Lessor and Lessee waive the provisions of any statutes
which relate to termination of leases when leased property is destroyed and
agree that such event shall be governed by the terms of this Lease.

10. REAL PROPERTY TAXES.

         10.1 PAYMENT OF TAX INCREASE. Lessor shall pay the real property tax,
as defined in paragraph 10.3, applicable to the Premises, provided, however,
that Lessee shall pay, in addition to rent, the amount, if any, by which real
property taxes applicable to the Premises increase over the fiscal real estate
tax year 1992-1993. Such payment shall be made by Lessee within thirty (30) days
after receipt of Lessor's written statement setting forth the amount of such
increase and the computation thereof. If the term of this Lease shall not expire
concurrently with the expiration of the tax fiscal year, Lessee's liability for
increased taxes for the last partial lease year shall be prorated on an annual
basis.

         10.2 ADDITIONAL IMPROVEMENTS. Notwithstanding paragraph 10.1 hereof,
Lessee shall pay to Lessor upon demand therefor the entirety of any increase in
real property tax if assessed solely by reason of additional improvements placed
upon the Premises by Lessee or at Lessee's request.

         10.3 DEFINITION OF "REAL PROPERTY TAX". As used herein, the term "real
property tax" shall include any form of real estate tax or assessment, general,
special, ordinary or extraordinary, and any license fee, commercial rental tax,
improvement bond or bonds, levy or tax (other than inheritance, personal income
or estate taxes) imposed on the Premises by any authority having the direct or
indirect power to tax, including any city, state or federal government, or any
school, agricultural, sanitary, fire, street, drainage or other improvement
district thereof, as against any legal or equitable interest of Lessor in the
Premises or in the real property of which the Premises are a part, as against
Lessor's right to rent or other income therefrom, and as against Lessor's
business of leasing the Premises. The term "real property tax" shall also
include any tax, fee, levy, assessment or charge (i) in substitution of,
partially or totally, any tax, fee, levy, assessment or charge hereinabove
included within the definition of "real property tax," or (ii) the nature of
which was hereinbefore included within the definition of "real property tax," or
(iii) which is imposed for a service or right not charged prior to June 1, 1978,
or, if previously charged, has been increased since June 1, 1978, or (iv) which
is imposed as a result of a transfer, either partial or total, of Lessor's
interest in the Premises or which is added to a tax or charge hereinbefore
included within the definition of real property tax by reason of such transfer,
or (v) which is imposed by reason of this transaction, any modifications or
changes hereto, or any transfers hereof.

         10.4 JOINT ASSESSMENT. If the Premises are not separately assessed,
Lessee's liability shall be an equitable proportion of the real property taxes
for all of the land and improvements included within the tax parcel assessed,
such proportion to be determined by Lessor from the respective valuations
assigned in the assessor's work sheets or such other information as may be
reasonably available. Lessor's reasonable determination thereof, in good faith,
shall be conclusive.

         10.5  PERSONAL PROPERTY TAXES.

         (a) Lessee shall pay prior to delinquency all taxes assessed against
and levied upon trade fixtures, furnishings, equipment and all other personal
property of Lessee contained in the Premises or elsewhere. When possible, Lessee
shall cause said trade fixtures, furnishings, equipment and all other personal
property to be assessed and billed separately from the real property of Lessor.

         (b) If any of Lessee's said personal property shall be assessed with
Lessor's real property, Lessee shall pay Lessor the taxes attributable to Lessee
within 10 days after receipt of a written statement setting forth the taxes
applicable to Lessee's property.

11. UTILITIES. Lessee shall pay for all water, gas, heat, light, power,
telephone and other utilities and services supplied to the Premises, together
with any taxes thereon. If any such services are not separately metered to
Lessee, Lessee shall pay a reasonable proportion to be determined by Lessor of
all charges jointly metered with other premises.

12.  ASSIGNMENT AND SUBLETTING.

         12.1 LESSOR'S CONSENT REQUIRED. Lessee shall not voluntarily or by
operation of law assign, transfer, mortgage, sublet, or otherwise transfer or
encumber all or any part of Lessee's interest in this Lease or in the



                                       7
<PAGE>

Premises, without Lessor's prior written consent, which Lessor shall not
unreasonably withhold. Lessor shall respond to Lessee's request for consent
hereunder in a timely manner and any attempted assignment, transfer, mortgage,
encumbrance or subletting without such consent shall be void, and shall
constitute a breach of this Lease.

         12.2 LESSEE AFFILIATE. Notwithstanding the provisions of paragraph 12.1
hereof, Lessee may assign or sublet the Premises, or any portion thereof,
without Lessor's consent, to any corporation which controls, is controlled by or
is under common control with Lessee, or to any corporation resulting from the
merger or consolidation with Lessee, or to any person or entity which acquires
all the assets of Lessee as a going concern of the business that is being
conducted on the Premises, provided that said assignee assumes, in full, the
obligations of Lessee under this Lease. Any such assignment shall not, in any
way, affect or limit the liability of Lessee under the terms of this Lease even
if after such assignment or subletting the terms of this Lease are materially
changed or altered without the consent of Lessee, the consent of whom shall not
be necessary.

         12.3 NO RELEASE OF LESSEE. Regardless of Lessor's consent, no
subletting or assignment shall release Lessee of Lessee's obligations or after
the primary liability of Lessee to pay the rent and to perform all other
obligations to be performed by Lessee hereunder. The acceptance of rent by
Lessor from any other person shall not be deemed to be a waiver by Lessor of any
provision hereof. Consent to one assignment or subletting shall not be deemed
consent to any subsequent assignment or subletting. In the event of default by
any assignee of Lessee or any successor of Lessee, in the performance of any of
the terms hereof, Lessor may proceed directly against Lessee without the
necessity of exhausting remedies against said assignee. Lessor may consent to
subsequent assignments or subletting of this Lease or amendments or
modifications to this Lease with assignees of Lessee, without notifying Lessee,
or any successor of Lessee, and without obtaining its or their consent thereto
and such action shall not relieve Lessee of liability under this Lease.

         12.4 ATTORNEY'S FEE. In the event Lessee shall assign or sublet the
Premises or request the consent of Lessor to any assignment or subletting or if
Lessee shall request the consent of Lessor for any act Lessee proposes to do
then Lessee shall pay Lessor's reasonable attorneys fees incurred in connection
therewith, such attorneys fees not to exceed $350.00 for each such request.

13. DEFAULTS; REMEDIES.

         13.1 DEFAULTS. The occurrence of any one or more of the following
events shall constitute a material default and breach of this Lease by Lessee:

         (a)  The vacating or abandonment of the Premises by Lessee.

         (b) The failure by Lessee to make any payment of rent or any other
payment required to be made by lessee hereunder, as and when due, where such
failure shall continue for a period of three days after written notice thereof
from Lessor to Lessee. In the event that Lessor serves Lessee with a Notice to
Pay Rent or Quit pursuant to applicable Unlawful Detainer statutes such Notice
to Pay Rent or Quit shall also constitute the notice required by this
subparagraph.

         (c) The failure by Lessee to observe or perform any of the covenants,
conditions or provisions of this Lease to be observed or performed by Lessee,
other than described in paragraph (b) above, where such failure shall continue
for a period of 30 days after written notice thereof from Lessor to Lessee;
provided, however, that if the nature of Lessee's default is such that more than
30 days are reasonably required for its cure, then Lessee shall not be deemed to
be in default if Lessee commenced such cure within said 30-day period and
thereafter diligently prosecutes such cure to completion.

         (d)(i) The making by Lessee of any general arrangement or assignment
for the benefit of creditors; (ii) Lessee becomes a "debtor" as defined in 11
U.S.C. Section 101 or any successor statute thereto (unless, in the case of a
petition filed against Lessee, the same is dismissed within 60 days); (iii) the
appointment of a trustee or receiver to take possession of substantially all of
Lessee's assets located at the Premises or of Lessee's interest in this Lease,
where possession is not restored to Lessee within 30 days; or (iv) the
attachment, execution or other judicial seizure of substantially all of Lessee's
assets located at the Premises or of Lessee's interest in this Lease, where such
seizure is not discharged within 30 days. Provided, however, in the event that
any provision of this paragraph 13.1(d) is contrary to any applicable law, such
provision shall be of no force or effect.

         (e) The discovery by Lessor that any financial statement given to
Lessor by Lessee, any assignee of Lessee, any subtenant of Lessee, any successor
in interest of Lessee or any guarantor of Lessee's obligation hereunder, and any
of them, was materially false.


                                       8
<PAGE>

         13.2 REMEDIES. In the event of any such material default or breach by
Lessee, Lessor may at any time thereafter, with or without notice or demand and
without limiting Lessor in the exercise of any right or remedy which Lessor may
have by reason of such default or breach:

         (a) Terminate Lessee's right to possession of the Premises by any
lawful means, in which case this Lease shall terminate and Lessee shall
immediately surrender possession of the Premises to Lessor. In such event Lessor
shall be entitled to recover from Lessee all damages incurred by Lessor by
reason of Lessee's default including, but not limited to, the cost of recovering
possession of the Premises; expenses of reletting, including necessary
renovation and alteration of the Premises, reasonable attorney's fees, and any
real estate commission actually paid; the worth at the time of award by the
court having jurisdiction thereof of the amount by which the unpaid rent for the
balance of the term after the time of such award exceeds the amount of such
rental loss for the same period that Lessee proves could be reasonably avoided;
that portion of the leasing commission paid by Lessor pursuant to Paragraph 15
applicable to the unexpired term of this Lease.

         (b) Maintain Lessee's right to possession in which case this Lease
shall continue in effect whether or not Lessee shall have abandoned the
Premises. In such event Lessor shall be entitled to enforce all of Lessor's
rights and remedies under this Lease, including the right to recover the rent as
it becomes due hereunder.

         (c) Pursue any other remedy now or hereafter available to Lessor under
the laws or judicial decisions of the state wherein the Premises are located.
Unpaid installments of rent and other unpaid monetary obligations of Lessee
under the terms of this Lease shall bear interest from the date due at the
maximum rate then allowable by law.

         13.3 DEFAULT BY LESSOR. Lessor shall not be in default unless Lessor
fails to perform obligations required of Lessor within a reasonable time, but in
no event later than thirty (30) days after written notice by Lessee to Lessor
and to the holder of any first mortgage or deed of trust covering the Premises
whose name and address shall have theretofore been furnished to Lessee in
writing, specifying wherein Lessor has failed to perform such obligation;
provided, however, that if the nature of Lessor's obligation is such that more
than thirty (30) days are required for performance then Lessor shall not be in
default if Lessor commences performance within such 30-day period and thereafter
diligently prosecutes the same to completion.

         13.4 LATE CHARGES. Lessee hereby acknowledges that late payment by
Lessee to Lessor of rent and other sums due hereunder will cause Lessor to incur
costs not contemplated by this Lease, the exact amount of which will be
extremely difficult to ascertain. Such costs include, but are not limited to,
processing and accounting charges, and late charges which may be imposed on
Lessor by the terms of any mortgage or trust deed covering the Premises.
Accordingly, if any installment of rent or any other sum due from Lessee shall
not be received by Lessor or Lessor's designee within ten (10) days after such
amount shall be due, then, without any requirement for notice to Lessee, Lessee
shall pay to Lessor a late charge equal to 6% of such overdue amount. The
parties hereby agree that such late charge represents a fair and reasonable
estimate of the costs Lessor will incur by reason of late payment by Lessee.
Acceptance of such late charge by lessor shall in no event constitute a waiver
of Lessee's default with respect to such overdue amount, nor prevent Lessor from
exercising any of the other rights and remedies granted hereunder. In the event
that a late charge is payable hereunder, whether or not collected, for three (3)
consecutive installments of rent, then rent shall automatically become due and
payable quarterly in advance, rather than monthly, notwithstanding paragraph 4
or any other provision of this Lease to the contrary.

         13.5 IMPOUNDS. In the event that a late charge is payable hereunder,
whether or not collected, for three (3) installments of rent or any other
monetary obligation of Lessee under the terms of this Lease, Lessee shall pay to
Lessor, if Lessor shall so request, in addition to any other payments required
under this Lease, a monthly advance installment, payable at the same time as the
monthly rent, as estimated by Lessor, for real property tax and insurance
expenses on the Premises which are payable by Lessee under the terms of this
Lease. Such fund shall be established to insure payment when due, before
delinquency, of any or all such real property taxes and insurance premiums. If
the amounts paid to Lessor by Lessee under the provisions of this paragraph are
insufficient to discharge the obligations of Lessee to pay such real property
taxes and insurance premiums as the same become due, Lessee shall pay to Lessor,
upon Lessor's demand, such additional sums necessary to pay such obligations.
All moneys paid to Lessor under this paragraph may be intermingled with other
moneys of Lessor and shall not bear interest. In the event of a default in the
obligations of Lessee to perform under this Lease, then any balance remaining
from funds paid to Lessor under the provisions of this paragraph may, at the
option of Lessor, be applied to the payment of any monetary default of Lessee in
lieu of being applied to the payment of real property tax and insurance
premiums.


                                       9
<PAGE>

14. CONDEMNATION. If the Premises or any portion thereof are taken under the
power of eminent domain, or sold under the threat of the exercise of said power
(all of which are herein called "condemnation"), this Lease shall terminate as
to the part so taken as of the date the condemning authority takes title or
possession, whichever first occurs. If more than 10% of the floor area of the
building on the Premises, or more than 25% of the land area of the Premise which
is not occupied by any building, is taken by condemnation, Lessee may, at
Lessee's option, to be exercised in writing only within ten (10) days after
Lessor shall have given Lessee written notice of such taking (or in the absence
of such notice, within ten (10) days after the condemning authority shall have
taken possession) terminate this Lease as of the date the condemning authority
takes such possession. If Lessee does not terminate this Lease in accordance
with the foregoing, this Lease shall remain in full force and effect as to the
portion of the Premises remaining, except that the rent shall be reduced in the
proportion that the floor area of the building taken bears to the total floor
area of the building situated on the Premises. No reduction of rent shall occur
if the only area taken is that which does not have a building located thereon.
Any award for the taking of all or any part of the Premises under the power of
eminent domain or any payment made under threat of the exercise of such power
shall be the property of Lessor, whether such award shall be made as
compensation for diminution in value of the leasehold or for the taking of the
fee, or as severance damages; provided, however, that Lessee shall be entitled
to any award for loss of or damage to Lessee's trade fixtures and removable
personal property. In the event that this Lease is not terminated by reason of
such condemnation, Lessor shall to the extent of severance damages received by
lessor in connection with such condemnation, repair any damage to the Premises
caused by such condemnation except to the extent that Lessee has been reimbursed
therefor by the condemning authority. Lessee shall pay any amount in excess of
such severance damages required to complete such repair.

15. ESTOPPEL CERTIFICATE.

         (a) Lessee shall at any time upon not less than ten (10) days' prior
written notice from Lessor execute, acknowledge and deliver to Lessor a
statement in writing (i) certifying that this Lease is unmodified and in full
force and effect (or, if modified, stating the nature of such modification and
certifying that this Lease, as so modified, is in full force and effect) and the
date to which the rent and other charges are paid in advance, if any, and (ii)
acknowledging that there are not, to Lessee's knowledge, any uncured defaults on
the part of Lessor hereunder, or specifying such defaults if any are claimed.
Any such statements may be conclusively relied upon by any prospective purchaser
or encumbrancer of the Premises.

         (b) At Lessor's option, Lessee's failure to deliver such statement
within such time shall be a material breach of this Lease or shall be conclusive
upon Lessee (i) that this Lease is in full force and effect, without
modification except as may be represented by Lessor, (ii) that there are no
uncured defaults in Lessor's performance, and (iii) that not more than one
month's rent has been paid in advance or such failure may be considered by
Lessor as a default by Lessee under this Lease.

         (c) If Lessor desires to finance, refinance, or sell the Premises, or
any part thereof, Lessee hereby agrees to deliver to any lender or purchaser
designated by Lessor such financial statements of Lessee as may be reasonably
required by such lender or purchaser. Such statements shall include the past
three years' financial statements of Lessee. All such financial statements shall
be received by Lessor and such lender or purchaser in confidence and shall be
used only for the purposes herein set forth.

16. LESSOR'S LIABILITY. The term "Lessor" as used herein shall mean only the
owner or owners at the time in question of the fee title or a lessee's interest
in a ground lease of the Premises, and except as expressly provided in Paragraph
15, in the event of any transfer of such title or interest. Lessor herein named
(and in case of any subsequent transfers then the grantor) shall be relieved
from and after the date of such transfer of all liability as respects Lessor's
obligations thereafter to be performed, provided that any funds in the hands of
Lessor or the then grantor at the time of such transfer, in which Lessee has an
interest, shall be delivered to the grantee. The obligations contained in this
Lease to be performed by Lessor shall, subject as aforesaid, be binding on
Lessor's successors and assigns, only during their respective periods of
ownership.

17. SEVERABILITY. The invalidity of any provision of this Lease as determined by
a court of competent jurisdiction, shall in no way affect the validity of any
other provision hereof.

18. INTEREST ON PAST-DUE OBLIGATIONS. Except as expressly herein provided, any
amount due to Lessor not paid when due shall bear interest at the maximum rate
then allowable by law from the date due. Payment of such interest shall not
excuse or cure any default by Lessee under this Lease, provided, however, that
interest shall not be payable on late charges incurred by Lessee nor on any
amounts upon which late charges are paid by Lessee.


                                       10
<PAGE>

19. TIME OF ESSENCE. Time is of the essence.

20. ADDITIONAL RENT. Any monetary obligations of Lessee to Lessor under the
terms of this Lease shall be deemed to be rent.

21. INCORPORATION OF PRIOR AGREEMENTS; AMENDMENTS. This Lease contains all
agreements of the parties with respect to any matter mentioned herein. No prior
agreement or understanding pertaining to any such matter shall be effective.
This Lease may be modified in writing only, signed by the parties in interest at
the time of the modification. Except as otherwise stated in this Lease, Lessee
hereby acknowledges that neither the real estate broker listed in Paragraph 15
hereof nor any cooperating broker on this transaction nor the Lessor or any
employees or agents of any of said persons has made any oral or written
warranties or representations to Lessee relative to the condition or use by
Lessee of said Premises and Lessee acknowledges that Lessee assumes all
responsibility regarding the Occupational Safety Health Act, the legal use and
adaptability of the Premises and the compliance thereof with all applicable laws
and regulations in effect during the term of this Lease except as otherwise
specifically stated in this Lease.

22. NOTICES. Any notice required or permitted to be given hereunder shall be in
writing and may be given by personal delivery or by certified mail, and if given
personally or by mail, shall be deemed sufficiently given if addressed to Lessee
or to Lessor at the address noted below the signature of the respective parties,
as the case may be. Either party may by notice to the other specify a different
address for notice purposes except that upon Lessee's taking possession of the
Premises, the Premises shall constitute Lessee's address for notice purposes. A
copy of all notices required or permitted to be given to Lessor hereunder shall
be concurrently transmitted to such party or parties at such addresses as Lessor
may from time to time hereafter designate by notice to Lessee.

23. WAIVERS. No waiver by Lessor or any provision hereof shall be deemed a
waiver of any other provision hereof or of any subsequent breach by Lessee of
the same or any other provision. Lessor's consent to, or approval of any act,
shall not be deemed to render unnecessary the obtaining of Lessor's consent to
or approval of any subsequent act by Lessee. The acceptance of rent hereunder by
Lessor shall not be a waiver of any preceding breach by Lessee of any provision
hereof, other than the failure of Lessee to pay the particular rent so accepted,
regardless of Lessor's knowledge of such preceding breach at the time of
acceptance of such rent.

24. RECORDING. Either Lessor or Lessee shall, upon request of the other,
execute, acknowledge and deliver to the other a "short form" memorandum of this
Lease for recording purposes.

25. HOLDING OVER. If Lessee, with Lessor's consent, remains in possession of the
Premises or any part thereof after the expiration of the term hereof, such
occupancy shall be a tenancy from month to month upon all the provisions of this
Lease pertaining to the obligations of Lessee, but all options and rights of
first refusal, if any, granted under the terms of this Lease shall be deemed
terminated and be of no further effect during said month to month tenancy.

26. CUMULATIVE REMEDIES. No remedy or election hereunder shall be deemed
exclusive but shall, wherever possible, be cumulative with all other remedies at
law or in equity.

27. COVENANTS AND CONDITION. Each provision of this Lease performable by Lessee
shall be deemed both a covenant and a condition.

28. BINDING EFFECT; CHOICE OF LAW. Subject to any provisions hereof restricting
assignment or subletting by Lessee and subject to the provisions of Paragraph
17, this Lease shall bind the parties, their personal representatives,
successors and assigns. This Lease shall be governed by the laws of the State
wherein the Premises are located.

29. SUBORDINATION.

         (a) This Lease, at Lessor's option, shall be subordinate to any ground
lease, mortgage, deed of trust, or any other hypothecation or security now or
hereafter placed upon the real property of which the Premises are a part and to
any and all advances made on the security thereof and to all renewals,
modifications, consolidations, replacements and extensions thereof.
Notwithstanding such subordination, Lessee's right to quiet possession of the
Premises shall not be disturbed if Lessee is not in default and so long as
Lessee shall pay the rent and observe and perform all of the provisions of this
Lease, unless this Lease is otherwise terminated pursuant to its terms. If any
mortgagee, trustee or ground lessor shall elect to have this Lease prior to the
lien of its mortgage, deed of trust or ground lease, and shall give written
notice thereof to Lessee, this Lease shall be deemed prior to such mortgage,
deed of trust, or ground lease, whether this Lease is dated prior or subsequent
to the date of said mortgage, deed of trust or ground lease or the date of
recording thereof.


                                       11
<PAGE>

         (b) Lessee agrees to execute any documents required to effectuate an
attornment, a subordination or to make this Lease prior to the lien of any
mortgage, deed of trust or ground lease, as the case may be, Lessee's failure to
execute such documents within 10 days after written demand shall constitute a
material default by Lessee hereunder, or, at Lessor's option, Lessor shall
execute such documents on behalf of Lessee as Lessee's attorney-in-fact. Lessee
does hereby make, constitute and irrevocably appoint Lessor as Lessee's
attorney-in-fact and in Lessee's name, place and stead, to execute such
documents in accordance with this paragraph 29(b).

30. ATTORNEY'S FEES. If either party or the broker named herein brings an action
to enforce the terms hereof or declare rights hereunder, the prevailing party in
any such action, on trial or appeal, shall be entitled to his reasonable
attorney's fees to be paid by the losing party as fixed by the court. The
provisions of this paragraph shall inure to the benefit of the broker named
herein who seeks to enforce a right hereunder.

31. LESSOR'S ACCESS. Lessor and Lessor's agents shall have the right to enter
the Premises at reasonable times for the purpose of inspecting the same, showing
the same to prospective purchasers, lenders, or lessees, and making such
alterations, repairs, improvements or additions to the Premises or to the
building of which they are a part as Lessor may deem necessary or desirable.
Lessor may at any time place on or about the Premises any ordinary "For Sale"
signs and Lessor may at any time during the last 120 days of the term hereof
place on or about the Premises any ordinary "For Lease" signs, all without
rebate of rent or liability to Lessee.

32. AUCTIONS. Lessee shall not conduct, nor permit to be conducted, either
voluntarily or involuntarily, any auction upon the Premises without first having
obtained Lessor's prior written consent. Notwithstanding anything to the
contrary in this Lease, Lessor shall not be obligated to exercise any standard
of reasonableness in determining whether to grant such consent.

33. SIGNS. Lessee shall not place any sign upon the Premises without Lessor's
prior written consent except that Lessee shall have the right without the prior
permission of Lessor to place ordinary and usual for rent or sublet signs
thereon.

34. MERGER. The voluntary or other surrender of this Lease by Lessee, or a
mutual cancellation thereof, or a termination by Lessor, shall not work a
merger, and shall, at the option of Lessor, terminate all or any existing
subtenancies or may, at the option of Lessor, operate as an assignment to Lessor
of any or all of such subtenancies.

35. CONSENTS. Except for paragraph 32 hereof, wherever in this Lease the consent
of one party is required to an act of the other party, such consent shall not be
unreasonably withheld.

36. GUARANTOR. In the event that there is a guarantor of this Lease, said
guarantor shall have the same obligations as Lessee under this Lease.

37. QUIET POSSESSION. Upon Lessee paying the rent for the Premises and observing
and performing all of the covenants, conditions and provisions on Lessee's part
to be observed and performed hereunder, Lessee shall have quiet possession of
the Premises for the entire term hereof subject to all of the provisions of this
Lease. The individuals executing this Lease on behalf of Lessor represent and
warrant to Lessee that they are fully authorized and legally capable of
executing this Lease on behalf of Lessor and that such execution is binding upon
all parties holding an ownership interest in the Premises.

38. OPTIONS.

         38.1 DEFINITION. As used in this paragraph the word "Options" has the
following meaning: (1) the right or option to extend the term of this Lease or
to renew this Lease or to extend or renew any lease that Lessee has on other
property of Lessor; (2) the option or right of first refusal to lease the
Premises or the right of first offer to lease the Premises or the right of first
refusal to lease other property of Lessor or the right of first offer to lease
other property of Lessor; (3) the right or option to purchase the Premises, or
the right of first refusal to purchase the Premises, or the right of first offer
to purchase the Premises or the right or option to purchase other property of
Lessor, or the right of first refusal to purchase other property of Lessor or
the right of first offer to purchase other property of Lessor.

         38.2 OPTIONS PERSONAL. Each Option granted to Lessee in this Lease are
personal to Lessee and may not be exercised or be assigned, voluntarily or
involuntarily, by or to any person or entity other than Lessee, provided,
however, the Option may be exercised by or assigned to any Lessee Affiliate as
defined in paragraph 12.2 of this Lease. The Options herein granted to Lessee
are not assignable separate and apart from this Lease.


                                       12
<PAGE>

         38.3 MULTIPLE OPTIONS. In the event that Lessee has any multiple
options to extend or renew this Lease a later option cannot be exercised unless
the prior option to extend or renew this Lease has been so exercised.

         38.4  EFFECT OF DEFAULT ON OPTIONS.

         (a) Lessee shall have no right to exercise an Option, notwithstanding
any provision in the grant of Option to the contrary, (i) during the time
commencing from the date Lessor gives to Lessee a notice of default pursuant to
paragraph 13.1(b) or 13.1(c) and continuing until the default alleged in said
notice of default is cured, or (ii) during the period of time commencing on the
day after a monetary obligation to Lessor is due from Lessee and unpaid (without
any necessity for notice thereof to Lessee) continuing until the obligation is
paid, or (iii) at any time after an event of default described in paragraphs
13.1(a), 13.1(d), or 13.1(e) (without any necessity of Lessor to give notice of
such default to Lessee), or (iv) in the event that Lessor has given to Lessee
three or more notices of default under paragraph 13.1(b), where a late charge
becomes payable under paragraph 13.4 for each of such defaults, or paragraph
13.1(c), whether or not the defaults are cured, during the 12 month period prior
to the time that Lessee intends to exercise the subject Option.

         (b) The period of time within which an Option may be exercised shall
not be extended or enlarged by reason of Lessee's inability to exercise an
Option because of the provisions of paragraph 38.4(a).

         (c) All rights of Lessee under the provisions of an Option shall
terminate and be of no further force or effect, notwithstanding Lessee's due and
timely exercise of the Option, if, after such exercise and during the term of
this Lease, (i) Lessee fails to pay to Lessor a monetary obligation of Lessee
for a period of 30 days after such obligation becomes due (without any necessity
of Lessor to give notice thereof to Lessee) or (ii) Lessee fails to commence to
cure a default specified in paragraph 13.1(c) within 30 days after the date that
Lessor gives notice to Lessee of such default and/or Lessee fails thereafter to
diligently prosecute said cure to completion, or (iii) Lessee commits a default
described in paragraph 13.1(a), 13.1(d) or 13.1(e) (without any necessity of
Lessor to give notice of such default to Lessee), or (iv) Lessor gives to Lessee
three or more notices of default under paragraph 13.1(b), where a late charge
becomes payable under paragraph 13.4 for each such default, or paragraph
13.1(c), whether or not the defaults are cured.

39. MULTIPLE TENANT BUILDING. In the event that the Premises are part of a
larger building or group of buildings then Lessee agrees that it will abide by,
keep and observe all reasonable rules and regulations which Lessor may make from
time to time for the management, safety, care, and cleanliness of the building
and grounds, the parking of vehicles and the preservation of good order therein
as well as for the convenience of other occupants and tenants of the building.
The violations of any such rules and regulations shall be deemed a material
breach of this Lease by Lessee.

40. SECURITY MEASURES. Lessee hereby acknowledges that the rental payable to
Lessor hereunder does not include the cost of guard service or other security
measures, and that Lessor shall have no obligation whatsoever to provide same.
Lessee assumes all responsibility for the protection of Lessee, its agents and
invitees from acts of third parties.

41. EASEMENTS. Lessor reserves to itself the right, from time to time, to grant
such easements, rights and dedications that Lessor deems necessary or desirable,
and to cause the recordation of Parcel Maps and restrictions, so long as such
easements, rights dedications, Maps and restrictions do not unreasonably
interfere with the use of the Premises by Lessee. Lessee shall sign any of the
aforementioned documents upon request of Lessor and failure to do so shall
constitute a material breach of this Lease.

42. PERFORMANCE UNDER PROTEST. If at any time a dispute shall arise as to any
amount or sum of money to be paid by one party to the other under the provisions
hereof, the party against whom the obligation to pay the money is asserted shall
have the right to make payment "under protest" and such payment shall not be
regarded as a voluntary payment, and there shall survive the right on the part
of said party to institute suit for recovery of such sum. If it shall be
adjudged that there was no legal obligation on the part of said party to pay
such sum or any part thereof, said party shall be entitled to recover such sum
or so much thereof as it was not legally required to pay under the provisions of
this Lease.

43. AUTHORITY. If Lessee is a corporation, trust, or general or limited
partnership, each individual executing this Lease on behalf of such entity
represents and warrants that he or she is duly authorized to execute and deliver
this Lease on behalf of said entity. If Lessee is a corporation, trust or
partnership, Lessee shall, within thirty (30) days after execution of this
Lease, deliver to Lessor evidence of such authority satisfactory to Lessor.


                                       13
<PAGE>

44. CONFLICT. Any conflict between the printed provisions of this Lease and the
typewritten or handwritten provisions shall be controlled by the typewritten or
handwritten provisions.

45. ADDENDUM. Attached hereto is an addendum and Exhibit A which constitutes a
part of this Lease.





LESSOR AND LESSEE HAVE CAREFULLY READ AND REVIEWED THIS LEASE AND EACH TERM AND
PROVISION CONTAINED HEREIN AND, BY EXECUTION OF THIS LEASE, SHOW THEIR INFORMED
AND VOLUNTARY CONSENT THERETO, THE PARTIES HEREBY AGREE THAT, AT THE TIME THIS
LEASE IS EXECUTED, THE TERMS OF THIS LEASE ARE COMMERCIALLY REASONABLE AND
EFFECTUATE THE INTENT AND PURPOSE OF LESSOR AND LESSEE WITH RESPECT TO THE
PREMISES.

         IF THIS LEASE HAS BEEN FILLED IN IT HAS BEEN PREPARED FOR SUBMISSION TO
         YOUR ATTORNEY FOR HIS APPROVAL. NO REPRESENTATION OR RECOMMENDATION IS
         MADE BY THE AMERICAN INDUSTRIAL REAL ESTATE ASSOCIATION OR BY THE REAL
         ESTATE BROKER OR ITS AGENTS OR EMPLOYEES AS TO THE LEGAL SUFFICIENCY,
         LEGAL EFFECT, OR TAX CONSEQUENCES OF THIS LEASE OR THE TRANSACTION
         RELATING THERETO; THE PARTIES SHALL RELY SOLELY UPON THE ADVICE OF
         THEIR OWN LEGAL COUNSEL AS TO THE LEGAL AND TAX CONSEQUENCES OF THIS
         LEASE.

THE PARTIES HERETO HAVE EXECUTED THIS LEASE AT THE PLACE ON THE DATE SPECIFIED
IMMEDIATELY ADJACENT TO THEIR RESPECTIVE SIGNATURES.

Executed at
            ---------------------   -------------------------------------------
on                                  By /s/ Walter H. Y. Chang
   ------------------------------      ----------------------------------------
                                        Walter H. Y. Chang, General Manager.
                                        Westlake Development Co., Inc.

Address                             By
        -------------------------      ----------------------------------------
                                              "LESSOR" (Corporate Seal)

Executed at
            ---------------------   -------------------------------------------

on                                  By /s/ Douglas Gjerde
   ------------------------------      ----------------------------------------
                                        Douglas Gjerde, Ph.D., President.
                                        Interaction Chromatography, Inc.
Address                             By  Wholly Owned Subsidiary of Sarasep, Inc.
        -------------------------      ----------------------------------------

                                              "LESSEE" (Corporate Seal)
- ---------------------------------




                                       14
<PAGE>

ADDENDUM TO THAT CERTAIN LEASE DATED MAY 15, 1996 BY AND BETWEEN WESTLAKE
DEVELOPMENT CO., INC. (LESSOR) AND INTERACTION CHROMATOGRAPHY, INC. WHOLLY OWNED
SUBSIDIARY OF SARASEP INC. (LESSEE) FOR 9,110 SQUARE FEET OF SPACE LOCATED AT
2032 CONCOURSE DRIVE, SAN JOSE, CALIFORNIA (PREMISES).

46. RENT SCHEDULE.

       Rent for year 1 shall commence on June 1, 1997 at $13.80 per annum
amounting to $125,718.00, to be paid in 12 installments of $10,476.50 per month.
For years 2 to 5, there shall be an annual rent adjustment as specified in
Paragraph Four (4). Base rent shall be adjusted on each Adjustment Date to
reflect any increase in the cost of living. The adjustment will be calculated
upon the basis of the United States Department of Labor, Bureau of Labor
Statistics Consumer Price Index ("CPI") for all Urban Consumers (CPI-U),
subgroup "All Items" for the San Francisco - Oakland - San Jose, California
Metropolitan Area (1967=100) (the "INDEX"). The Index published nearest
preceding the Commencement Date is the "Base Index". The Index published nearest
preceding each Adjustment Date is the "Adjustment Index". On each Adjustment
Date, Base Rent shall be adjusted by multiplying the largest amount of rent
payable under Section 4 by a fraction, the numerator of which is the Adjustment
Index and the denominator of which is the Base Index. Notwithstanding the
foregoing, (a) in no event shall the monthly Base Rent be less than the largest
amount of monthly Base Rent set forth in Section 4, and (b) in no event shall
each net annual percentage increase in Base Rent be less than four percent (4%)
per annum, nor more than seven percent (7%) per annum.

47. TENANT IMPROVEMENTS.

       Lessor agrees to provide an amount up to Forty-seven Thousand Five
Hundred Eighty-six Dollars ($47,586.00) to Lessee to be applied to the total
estimated cost of improvements as per attached proposal submitted by San Jose
Construction Co., Inc. Lessor will reimburse Lessee after completion of said
improvements. Any and all other improvements shall be paid by Lessee.

48. TERMINATION OF THE LEASE.

       So long as Lessee is not in default of the terms of the lease, Lessee
shall have the right to terminate this Lease at the end of the 36th month or at
the end of the 48th month of the lease term by giving Lessor a notice at least
60 days prior thereto. Lessee shall pay to Lessor a fee of Nineteen Thousand
Thirty-four Dollars and Forty Cents (40% x $47,586.00 = $19,034.40) plus Two (2)
months' rent if Lessee elects to terminate the lease at the end of the 36th
month, or pay Nine Thousand Five Hundred Seventeen Dollars and Twenty Cents (20%
x $47,586.00 = $9,517.20) plus One (1) month's rent to terminate the lease at
the end of the 48th month.

49. STATEMENT OF SQUARE FOOTAGE.

       Any statements of square footage set forth in this Lease that have been
used in calculating rent or other Lessee's monetary obligations is an
approximation. Both Lessor and Lessee agree that the approximation is fair and
reasonable and the rent based thereon is not subject to revision whether or not
the actual square footage is more or less.



<PAGE>

FOR THE LESSOR:                                 FOR THE LESSEE
WESTLAKE DEVELOPMENT CO., INC.                  INTERACTION CHROMATOGRAPHY
                                                WHOLLY OWNED SUBSIDIARY OF
                                                SARASEP, INC.

By: /s/ Walter H.Y. Chang                       By: /s/ Douglas Gjerde
    -----------------------------                   ----------------------------
    Walter H. Y. Chang,                             Douglas Gjerde, Ph. D.
    General Manager.                                President.



                                       2
<PAGE>

                  [San Jose Construction Co., Inc. Letterhead]


April 2, 1996

INTER ACTION CHROMATOGRAPHY, INC.
2032 Concourse Drive
San Jose, CA  95131

Attn:             Mr. David Hometchko
Re:               INTER ACTION CHROMATOGRAPHY
Subject:          Plan Changes due to Plan Check Comments

Dear Mr. Hometchko,

Enclosed is the detailed cost breakdown for changes associated with plan check
comments and the construction of the 1-hour rated corridor. I would be happy to
sit down with you to go over the cost impacts in detail in relation to the plan.

The basic impacts are as follows:

- -    All existing sidelites must be replaced with 45 minute rated frames and
     wire glazing. New sidelite at Office 127 must be 45 minute rated assembly
     also.

- -    Three new rated doors, frames & hardware have been added as well as wall
     framing associated with these doors.

- -    Ceilings of corridor are now framed and sheetrocked which includes paint,
     relocated sprinkler drops, relocated light fixtures and relocated ductwork.
     Acoustical ceiling tile must be removed now to allow for tunnel
     construction.

- -    Overall schedule will increase by 1 week requiring additional supervision.

- -    Parking lot striping and signage are included per plan.

- -    Additional area at rear corridor requires electrical & sprinkler
     modifications not included in the first pricing.

- -    Permit fees have increased slightly due to revised valuation.

We are requesting a change order in the amount of:  $28,162.

Please do not hesitate to contact me if you have any questions or comments.

Sincerely,

SAN JOSE CONSTRUCTION CO., INC.

Tina Moore
Project Manager


<PAGE>

                  [San Jose Construction Co., Inc. Letterhead]

                                                                Dated:  04/02/96


SAN JOSE CONSTRUCTION

INTER ACTION CHROMATOGRAPHY, INC.                                       2,262 SF
2032 CONCOURSE DRIVE
SAN JOSE, CA

<TABLE>
<CAPTION>

     COST                                                             ORIGINAL            PLAN          REVISED
     CODE                          DESCRIPTION                        CONTRACT           CHECK           TOTAL
                                                                                       REVISIONS
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------
<S>     <C>      <C>                                                   <C>              <C>                <C>
        11200    Project Supervision                                   $4,381           $1,219             $5,600
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------
        13100    Temporaries/visqueen barrier                             230              200                430
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------
        17150    Clean Up                                                 280              122                402
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------
        28400    Parking Lot Striping & Signage                             0              460                460
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------
        62200    Millwork                                                 965                0                965
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------
        81000    Doors/Frames/Hardware                                  3,400            7,850             11,250
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------
        88000    Glass & Glazing                                            0            1,652              1,852
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------
        92500    Metal Stud Framing/Sheetrock                           5,650            6,903             12,553
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------
        95000    Acoustical Ceilings                                      600              720              1,320
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------
        96800    Rubber Topset Base @ new walls                           580                0                580
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------
        99000    Painting                                               2,525              830              3,355
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------
       153000    Fire Sprinklers                                          980            2,870              3,850
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------
       154000    Plumbing                                               4,451                0              4,461
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------
       155000    HVAC                                                   5,410              560              5,970
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------
       160000    Electrical                                            12,800            2,800             15,600
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------
                 Subtotal                                              42,252           26,186             68,438
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------
                 Building Permit                                        2,522              233              2,755
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------
                 General Contractors OH &P                              2,812            1,743              4,555
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------
                 Total                                                $47,586          $28,162            $75,748
- ---------------- ------------------------------------------------ ----------------- ---------------- ---------------

</TABLE>


<PAGE>


                                    EXHIBIT A

                       COMPLIANCE WITH LAW AND REGULATION

TENANT'S OBLIGATIONS.

Tenant shall, at its sole cost and expense, comply with all of the requirements
of all municipal, state and federal authorities now in force, or which may
hereafter be in force, pertaining to the leased premises, and shall faithfully
observe in the use of the leased premises all municipal ordinances and state and
federal statutes now in force or which may hereafter be in force. The judgement
of any court of competent jurisdiction, or the admission of Tenant in any action
or proceeding against Tenant, whether Landlord be a party thereto or not, that
any such ordinance or statute pertaining to the leased premises has been
violated, shall be conclusive of that fact as between Landlord and Tenant. As
part of its obligation hereunder, Tenant covenants that it will comply with all
applicable laws, rules, regulations, orders, permits, licenses and operating
plans of any governmental authority, including those relating to the receipt,
use, handling, generation, transportation, storage, treatment and/or disposal of
Hazardous Materials (as defined below).

CONDITION OF LEASED PREMISES.

Subject to Landlord's work, if any, Tenant hereby accepts the leased premises in
the condition existing as of the date of occupancy, subject to all applicable
zoning, municipal, county and state laws, ordinances, rules, regulations,
orders, restrictions of record, and requirements in effect during the term or
any part of the term hereof regulating the leased premises.

HAZARDOUS MATERIALS.

A) Hazardous Materials Defined: As used herein, the term "Hazardous Materials"
shall mean (i) any hazardous or toxic wastes, materials or substances, and any
other pollutants or contaminants, which are or may become regulated by any
applicable local, state or federal laws, including but not limited to 33 U.S.C.
Section 1251 ET SEQ., 42 U.S.C. Section 6901 ET SEQ., 42 U.S.C. Section 7401 ET
SEQ., 42 U.S.C. Section 9601 ET SEQ., and California Health and Safety Code
Section 25100 ET SEQ., Section 25300 ET SEQ., and Section 25500 ET SEQ.,
California Water Code, Section 13020 ET SEQ., or any successor(s) thereto
(collectively "environmental Law"); (ii) petroleum; (iii) asbestos; (iv)
polychlorinated biphenyls; and (v) radioactive materials.

B) Use, etc., of Hazardous Materials: Tenant agrees that during the term of this
lease, there shall be no use, presence, disposal, storage, generation
(collectively "Hazardous Use"), or intentional Release, as defined in 42 U.S.C.
9601 (22), or any successor(s) thereto, or threatened Release of Hazardous
Materials on, from or under the leased premises except to the extent that, and
in accordance with such conditions as, Landlord may have previously approved in
writing.

It is further agreed that, notwithstanding the previous sentence, Tenant shall
be entitled to use and store only those Hazardous Materials which are necessary
for Tenant's business, provided that such usage and storage is in full
compliance with Environmental Laws, and all judicial and administrative
decisions pertaining thereto. The signing of this lease constitutes Landlord




<PAGE>

approval for Tenant to use perchloroethylene on the premises as part of the
drycleaning process. Tenant shall not be entitled to install any tanks under, on
or about the leased premises for the storage of Hazardous Materials without the
express written consent of Landlord, which may be given or withheld in
Landlord's sole arbitrary judgment. For the purposes of this paragraph, the
terms Hazardous Use and Release shall include Hazardous Use(s) and/or Release(s)
of Hazardous Materials on, from or under the leased premises by any and all
tenants, occupants, and/or users of the leased premises (except Landlord).

C) Hazardous Materials Report, When Required: Tenant shall submit to Landlord a
written report with respect to Hazardous Materials ("Report") in the form
prescribed in subparagraph (D) below on the following dates:

(i)  Within ten (10) days after commencement date.
(ii) Within ten (10) days after each anniversary of the commencement date during
the term.
(iii) At any time within ten (10) days after written request by , and
(iv) At any time when there has been or is planned any condition
which constitutes or would constitute a change in the information submitted in
the most recent Report, including any notice of violation as referred to in
subparagraph (D) (vii) below.

D) Hazardous Materials Report; Contents: The report shall contain, without
limitation, the following information:

(i) Whether on the date of the Report and (if applicable) during the period
since the last Report there has been any Hazardous Use on, from or under the
leased premises.
(ii) If there was such Hazardous Use, the exact identity of the Materials, the
dates upon which such materials were brought upon the leased premises, the dates
upon which the Hazardous Materials were removed therefrom, and the quantity,
location, use and the purpose thereof.
(iii) If there was such Hazardous Use, any governmental permits maintained by
Tenant with respect to such Hazardous Materials, the issuing agency, original
date of issue, renewal dates (if any) and expiration date. Copies of any such
permits and applications therefor shall be attached.
(iv) If there was such Hazardous Use, any governmental reporting or inspection
requirements with respect to such Hazardous Materials, the governmental agency
to which reports are made and/or which conducts inspections, and the dates of
any such reports and/or inspections (if applicable) since the last Report.
Copies of any such Reports shall be attached.
(v) If there was such Hazardous Use, identification of any operation or business
plan prepared for any governmental agency with respect to Hazardous Use.
(vi) Any liability insurance carried by Tenant with respect to Hazardous
Materials, the insurer, policy number, date of issue, coverage amounts, and date
of expiration. Copies of any such policies or certificates of coverage shall be
attached.
(vii) Any notices of violation of Environmental Laws, written or oral, received
by Tenant from any governmental agency since last Report, the date, name of
agency, and description of violation. Copies of any such written notices shall
be attached.
(viii) Such other pertinent information or documents as are requested by
Landlord in writing.
(ix) With respect to any Hazardous Materials received, used, handled, generated,
transported, stored, treated or disposed, Tenant shall attach to the Report (or,
if the volume of the documents make it impracticable, shall make available to
Landlord) copies of all material safety data sheets




                                       2
<PAGE>

required to be completed with respect to the operations of Tenant at the leased
premises in accordance with Title 26, California Code of Regulations section
8-5194 or 42 U.S.C. Section 11021, or any amendments thereto.

E) Release of Hazardous Materials: Notification and Cleanup. If any time during
the term Tenant knows or believes that any Release of any Hazardous Materials
has come or will come to be located upon, about or beneath the leased premises,
then Tenant shall, as soon as reasonably possible, either prior to the Release
or following the discovery thereof by Tenant, give verbal and follow-up written
notice of that condition to Landlord. Tenant covenants to investigate, clean up
and otherwise remediate any Release of Hazardous Materials at Tenant's cost and
expense; such investigation, clean up and remediation shall be performed only
after Tenant has obtained Landlord's written consent, which shall not be
unreasonably withheld; provided, however, that Tenant shall be entitled to
respond immediately to an emergency without first obtaining Landlord's written
consent. All clean up and remediation shall be done to the reasonable
satisfaction of Landlord. It is the express intention of the parties hereto that
Tenant shall be liable under this Section HAZARDOUS MATERIALS only or any and
all conditions covered hereby which were caused or created by Tenant or Tenant's
business operation.

F) Inspection and Testing by Landlord. Landlord shall have the right at all
times during the term of this lease to (i) inspect the leased premises, and to
(ii) conduct tests and investigation to determine whether Tenant is in
compliance with the provisions of this Section, without being deemed guilty of,
or liable in any respect for any disturbance (actual or alleged) of Tenant's
use, enjoyment or occupation of the leased premises. Except in cases of
emergency, Landlord shall give reasonable notice to Tenant before conducting any
inspections, tests or investigations.

The cost of all such inspections, tests and investigations shall be borne by
Tenant, but only if Landlord reasonably believes them to be necessary and the
results of such Inspection, test or investigation finds the release of hazardous
materials by Tenant.

G) Indemnity. Tenant shall indemnify, defend and hold Landlord harmless from and
against any and all claims, judgements, damages, penalties, fines, liabilities,
losses, suits, administrative proceedings and costs (including, but not limited
to, attorneys' and consultants' fees) arising from or related to Hazardous Use
or Release of Hazardous Materials on or about the leased premises caused by the
acts or omissions of Tenant during the term of this lease. Tenant warrants that
it is leasing the premises "as-is, where-is," and that it has thoroughly
inspected the leased premises prior to execution of the lease.



                                       3


<PAGE>

                                                                      EXHIBIT 21

                           SUBSIDIARIES OF REGISTRANT

<TABLE>
<CAPTION>
        Name                                                    Jurisdiction of Organization
        ----                                                    -----------------------------
<S>                                                             <C>
1.      Transgenomic, Ltd. (f/k/a CETAC Technologies, Ltd.)     United Kingdom

2.      Transgenomic St. Thomas, Inc.                           St. Thomas, U.S. Virgin Islands
        (f/k/a CETAC St. Thomas, Inc.)
</TABLE>


<PAGE>

                                                                    EXHIBIT 23.1


INDEPENDENT AUDITORS' CONSENT

We consent to the use in this Registration Statement of Transgenomic, Inc.
and subsidiaries on Form S-1 of our report dated March 7, 2000 appearing in
the Prospectus, which is part of this Registration Statement.

We also consent to the reference to us under the headings "Selected Financial
Data" and "Experts" in such Prospectus.



/s/ DELOITTE & TOUCHE LLP

Omaha, Nebraska
March 9, 2000

<PAGE>


                                POWER OF ATTORNEY

         KNOW ALL MEN BY THERE PRESENTS that the undersigned, a director,
officer or both, of Transgenomic, Inc., a Delaware corporation (the "Company"),
acting pursuant to the authorization of the Board of Directors of the Company,
hereby appoints Collin J. D'Silva as my true and lawful attorney-in-fact to act
for me and in my name and on my behalf, individually and as an officer or
director or both of the Company, to sign a Registration Statement on Form S-1
under the Securities Act of 1933, as amended, and any amendment (including any
post-effective amendments) and supplements thereto with respect to the
registration of shares held by the shareholders of the Company and generally to
do and perform all things necessary to be done in connection with the foregoing
as fully in all respects as I could do personally.

         IN WITNESS WHEREOF, I have hereunto set my hand this 8th day of March,
2000.

                                                          /s/Gregory J. Duman
                                                          ----------------------
                                                          Gregory J. Duman



<PAGE>


                                POWER OF ATTORNEY

         KNOW ALL MEN BY THERE PRESENTS that the undersigned, a director,
officer or both, of Transgenomic, Inc., a Delaware corporation (the "Company"),
acting pursuant to the authorization of the Board of Directors of the Company,
hereby appoints Collin J. D'Silva as my true and lawful attorney-in-fact to act
for me and in my name and on my behalf, individually and as an officer or
director or both of the Company, to sign a Registration Statement on Form S-1
under the Securities Act of 1933, as amended, and any amendment (including any
post-effective amendments) and supplements thereto with respect to the
registration of shares held by the shareholders of the Company and generally to
do and perform all things necessary to be done in connection with the foregoing
as fully in all respects as I could do personally.

         IN WITNESS WHEREOF, I have hereunto set my hand this 9th day of March,
2000.

                                                          /s/Stephen F. Dwyer
                                                          ----------------------
                                                          Stephen F. Dwyer

<PAGE>


                                POWER OF ATTORNEY

         KNOW ALL MEN BY THERE PRESENTS that the undersigned, a director,
officer or both, of Transgenomic, Inc., a Delaware corporation (the "Company"),
acting pursuant to the authorization of the Board of Directors of the Company,
hereby appoints Collin J. D'Silva as my true and lawful attorney-in-fact to act
for me and in my name and on my behalf, individually and as an officer or
director or both of the Company, to sign a Registration Statement on Form S-1
under the Securities Act of 1933, as amended, and any amendment (including any
post-effective amendments) and supplements thereto with respect to the
registration of shares held by the shareholders of the Company and generally to
do and perform all things necessary to be done in connection with the foregoing
as fully in all respects as I could do personally.

         IN WITNESS WHEREOF, I have hereunto set my hand this 8th day of March,
2000.

                                                          /s/Douglas T. Gjerde
                                                          ----------------------
                                                          Douglas T. Gjerde


<PAGE>


                                POWER OF ATTORNEY

         KNOW ALL MEN BY THERE PRESENTS that the undersigned, a director,
officer or both, of Transgenomic, Inc., a Delaware corporation (the "Company"),
acting pursuant to the authorization of the Board of Directors of the Company,
hereby appoints Collin J. D'Silva as my true and lawful attorney-in-fact to act
for me and in my name and on my behalf, individually and as an officer or
director or both of the Company, to sign a Registration Statement on Form S-1
under the Securities Act of 1933, as amended, and any amendment (including any
post-effective amendments) and supplements thereto with respect to the
registration of shares held by the shareholders of the Company and generally to
do and perform all things necessary to be done in connection with the foregoing
as fully in all respects as I could do personally.

         IN WITNESS WHEREOF, I have hereunto set my hand this 8th day of March,
2000.

                                                          /s/Jeffrey Sklar
                                                          ----------------------
                                                          Jeffrey Sklar


<PAGE>


                                POWER OF ATTORNEY

         KNOW ALL MEN BY THERE PRESENTS that the undersigned, a director,
officer or both, of Transgenomic, Inc., a Delaware corporation (the "Company"),
acting pursuant to the authorization of the Board of Directors of the Company,
hereby appoints Collin J. D'Silva as my true and lawful attorney-in-fact to act
for me and in my name and on my behalf, individually and as an officer or
director or both of the Company, to sign a Registration Statement on Form S-1
under the Securities Act of 1933, as amended, and any amendment (including any
post-effective amendments) and supplements thereto with respect to the
registration of shares held by the shareholders of the Company and generally to
do and perform all things necessary to be done in connection with the foregoing
as fully in all respects as I could do personally.

         IN WITNESS WHEREOF, I have hereunto set my hand this 9th day of March,
2000.

                                                          /s/Roland J. Santoni
                                                          ----------------------
                                                          Roland J. Santoni


<PAGE>


                                POWER OF ATTORNEY

         KNOW ALL MEN BY THERE PRESENTS that the undersigned, a director,
officer or both, of Transgenomic, Inc., a Delaware corporation (the "Company"),
acting pursuant to the authorization of the Board of Directors of the Company,
hereby appoints Collin J. D'Silva as my true and lawful attorney-in-fact to act
for me and in my name and on my behalf, individually and as an officer or
director or both of the Company, to sign a Registration Statement on Form S-1
under the Securities Act of 1933, as amended, and any amendment (including any
post-effective amendments) and supplements thereto with respect to the
registration of shares held by the shareholders of the Company and generally to
do and perform all things necessary to be done in connection with the foregoing
as fully in all respects as I could do personally.

         IN WITNESS WHEREOF, I have hereunto set my hand this 8th day of March,
2000.

                                                      By   /s/ Gregory J. Duman
                                                          ----------------------
                                                      Name     Gregory J. Duman
                                                          ----------------------


<TABLE> <S> <C>

<PAGE>
<ARTICLE> 5
<CIK> 0001043961
<NAME> TRANSGENOMIC, INC.

<S>                             <C>                     <C>                     <C>
<PERIOD-TYPE>                   YEAR                   YEAR                   YEAR
<FISCAL-YEAR-END>                          DEC-31-1999             DEC-31-1998             DEC-31-1997
<PERIOD-START>                             JAN-01-1999             JAN-01-1998             JAN-01-1997
<PERIOD-END>                               DEC-31-1999             DEC-31-1998             DEC-31-1997
<CASH>                                         153,336                 187,455                       0
<SECURITIES>                                         0                       0                       0
<RECEIVABLES>                                6,359,652               4,987,064                       0
<ALLOWANCES>                                   160,593                 561,645                       0
<INVENTORY>                                  6,043,025               4,183,509                       0
<CURRENT-ASSETS>                            13,018,881               9,237,309                       0
<PP&E>                                       6,263,155               4,342,701                       0
<DEPRECIATION>                               3,682,016               2,931,886                       0
<TOTAL-ASSETS>                              19,963,510              14,736,064                       0
<CURRENT-LIABILITIES>                        9,525,000               7,392,419                       0
<BONDS>                                     12,537,968                 694,536                       0
                                0                       0                       0
                                          0                       0                       0
<COMMON>                                       130,000                 130,000                       0
<OTHER-SE>                                 (2,229,458)               6,519,109                       0
<TOTAL-LIABILITY-AND-EQUITY>                19,963,510              14,736,064                       0
<SALES>                                     23,034,954              18,935,440              11,576,677
<TOTAL-REVENUES>                            23,034,954              18,935,440              11,576,677
<CGS>                                       12,090,036               9,590,663               6,335,986
<TOTAL-COSTS>                               12,090,036               9,590,663               6,335,986
<OTHER-EXPENSES>                            17,828,519              11,319,529               8,459,029
<LOSS-PROVISION>                                     0                       0                       0
<INTEREST-EXPENSE>                           1,198,012                 531,648                 427,389
<INCOME-PRETAX>                            (8,081,613)             (2,506,400)             (3,645,727)
<INCOME-TAX>                                 1,745,273               (930,007)             (1,236,188)
<INCOME-CONTINUING>                        (9,826,886)             (1,576,393)             (2,409,539)
<DISCONTINUED>                                       0                       0                       0
<EXTRAORDINARY>                                      0                       0                       0
<CHANGES>                                            0                       0                       0
<NET-INCOME>                               (9,826,886)             (1,576,393)             (2,409,539)
<EPS-BASIC>                                     (0.76)                  (0.13)                  (0.22)
<EPS-DILUTED>                                   (0.76)                  (0.13)                  (0.22)


</TABLE>


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