CHEMDEX CORP
S-4, 1999-11-10
CHEMICALS & ALLIED PRODUCTS
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<PAGE>

   As filed with the Securities and Exchange Commission on November 10, 1999
                                                     Registration No. 333-
- -------------------------------------------------------------------------------
- -------------------------------------------------------------------------------
                      SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, DC 20549

                               ----------------

                                   FORM S-4
                            REGISTRATION STATEMENT
                                     Under
                          The Securities Act of 1933

                               ----------------
                              CHEMDEX CORPORATION
            (Exact Name of Registrant as Specified in Its Charter)

        Delaware                     5169                    77-0465469
     (State or Other           (Primary Standard          (I.R.S. Employer
     Jurisdiction of              Industrial             Identification No.)
    Incorporation or          Classification Code
      Organization)                 Number)

                                3950 Fabian Way
                              Palo Alto, CA 94303
                                (650) 813-0300
         (Address, Including Zip Code and Telephone Number, Including
            Area Code, of Registrant's Principal Executive Offices)

                                David P. Perry
                     President and Chief Executive Officer
                                3950 Fabian Way
                              Palo Alto, CA 94303
                                (650) 813-0300
           (Name, address, including zip code, and telephone number,
                  including area code, of agent for service)

                               ----------------

                                  Copies to:

           Jeffrey Y. Suto                       Geoffrey P. Leonard
         Steven J. Tonsfeldt                       Lowell D. Ness
          Kenneth D. Cramer                        Loren D. Danzis
            Mavis L. Yee                 Orrick, Herrington & Sutcliffe LLP
          Venture Law Group                        1020 Marsh Road
     A Professional Corporation             Menlo Park, California 94025
         2800 Sand Hill Road
    Menlo Park, California 94025

                               ----------------

   Approximate date of commencement of proposed sale to the public: Upon
consummation of the merger described herein.

   If the securities being registered on this form are being offered in
connection with the formation of a holding company and there is compliance
with General Instruction G, check the following box. [_]

   If this form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, check the following box and
list the Securities Act registration statement number of the earlier effective
registration statement for the same offering. [_]

   If this form is a post-effective amendment filed pursuant to Rule 462(d)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. [_]

                               ----------------

                        CALCULATION OF REGISTRATION FEE
<TABLE>
- -------------------------------------------------------------------------------
- -------------------------------------------------------------------------------
<CAPTION>
                                                         Proposed
                                            Proposed     Maximum
 Title of each Class of      Amount         Maximum     Aggregate   Amount of
    Securities to be          to be      Offering Price  Offering  Registration
       Registered        Registered(/1/)    Per Unit    Price(/2/)   Fee(/3/)
- -------------------------------------------------------------------------------
<S>                      <C>             <C>            <C>        <C>
Common Stock, par value
 $.0002.................   12,057,366                    $758.00     $100.00
- -------------------------------------------------------------------------------
- -------------------------------------------------------------------------------
</TABLE>
(1) Represents the maximum number of shares of Chemdex common stock to be
    issued in connection with the transaction.
(2) Estimated solely for the purposes of calculating the registration fee
    required by Section 6(b) of the Securities Act of 1933, as amended. This
    fee has been computed pursuant to Rule 457 (f)(2) and is based on (i) the
    par value of the common stock of Promedix and (ii) the estimated number of
    shares of Promedix common stock to be acquired by Chemdex pursuant to the
    merger.
(3) Represents the minimum registration fee. Calculation of the registration
    fee in accordance with Rule 457(f)(2) under the Securities Act of 1933
    yields a registration fee of less than the minimum.

                               ----------------

   The Registrant hereby amends this Registration Statement on such date or
dates as may be necessary to delay its effective date until the Registrant
shall file a further amendment which specifically states that this
Registration Statement shall thereafter become effective in accordance with
Section 8(a) of the Securities Act of 1933 or until this Registration
Statement shall become effective on such date as the Commission, acting
pursuant to said Section 8(a), may determine.

- -------------------------------------------------------------------------------
- -------------------------------------------------------------------------------
<PAGE>

                                [LOGO TO COME]

                              CHEMDEX CORPORATION

Dear Chemdex Stockholder:

   You are cordially invited to attend a special meeting of the stockholders
of Chemdex Corporation, a Delaware corporation, to be held at    a.m., Pacific
Standard time, on     , 1999, at the Company's executive offices at 1500
Plymouth Street, Mountain View, California.

   At the special meeting, you will be asked to consider and vote on the
following proposals:

     1. To approve the issuance of up to a maximum of 12,057,366 shares of
  Chemdex common stock for all shares of outstanding Promedix.com, Inc.
  capital stock, in connection with a merger whereby Promedix will become a
  wholly-owned subsidiary of Chemdex and Chemdex will assume Promedix's stock
  option plan.

     2. To increase the number of shares of Chemdex common stock available
  for issuance under the Chemdex 1999 Employee Stock Purchase Plan by 300,000
  shares to a total of 1,050,000 shares.

     3. To increase the number of shares of Chemdex common stock available
  for issuance under the Chemdex 1998 Stock Plan by 4,250,000 shares to a
  total of 10,375,000 shares.

     4. To transact any other business that properly comes before the special
  meeting or any adjournments or postponements thereof.

   If the merger is approved, each outstanding share of Promedix common stock
will be converted into the right to receive a fraction of one share of Chemdex
common stock and each outstanding option to purchase Promedix common stock
will become the right to acquire a number of shares of Chemdex common stock at
a price based on the same fraction. This fractional amount or exchange ratio
will be determined by dividing 12,057,366, the maximum number of shares of
Chemdex common stock to be issued as a result of this merger, by the sum of
the number of shares of Promedix capital stock outstanding and the number of
shares of capital stock issuable upon exercise of outstanding Promedix options
and warrants as of the closing date. Following the merger, Chemdex
stockholders will own approximately 75%, and Promedix stockholders will own
approximately 25%, of Chemdex.

   Chemdex's board of directors has carefully reviewed and considered the
issuance of the proposed Chemdex common stock in connection with the merger
and has concluded that such issuance is fair to and in the best interests of
Chemdex's stockholders. In reaching this determination, Chemdex's board of
directors received an advisory opinion of Morgan Stanley. Such opinion was
provided for the information and assistance of Chemdex's board of directors
and does not constitute a recommendation as to how any holder of shares of
Chemdex common stock should vote. The full text of the opinion, which sets
forth assumptions made, matters considered and limitations on the review
undertaken in connection with the opinion, is attached as Annex C to the proxy
statement and prospectus. You are urged to read this opinion in its entirety.

   YOUR BOARD HAS APPROVED THE STOCK ISSUANCE IN CONNECTION WITH THE MERGER
AND HAS DETERMINED THAT IT IS IN THE BEST INTERESTS OF CHEMDEX AND ITS
STOCKHOLDERS. AFTER CAREFUL CONSIDERATION, THE BOARD RECOMMENDS A VOTE "FOR"
APPROVAL OF THE COMMON STOCK ISSUANCE. CHEMDEX'S BOARD ALSO RECOMMENDS THAT
YOU VOTE "FOR" APPROVAL OF THE OTHER PROPOSALS BROUGHT BEFORE THE SPECIAL
MEETING.

   The stock issuance requires the affirmative vote of the holders of a
majority of the outstanding shares of Chemdex common stock represented at the
special meeting, in person or by proxy. Before you vote, you should read the
accompanying proxy statement and prospectus, which provides detailed
information concerning the proposed stock issuance, merger and other
proposals, as well as additional information concerning Chemdex and Promedix.
In particular, you should review the matters referred to under the "Risk
Factors" starting on page  .
<PAGE>

The complete text of the merger agreement is attached as Annex A to the proxy
statement and prospectus. You may revoke your proxy at any time prior to its
exercise by filing a written notice of your revocation with the Secretary of
Chemdex or by signing and delivering to the Secretary a proxy bearing a later
date. In addition, you may attend the special meeting and vote your shares in
person if you wish, even though you have previously returned your proxy.

   YOUR VOTE IS VERY IMPORTANT. WHETHER OR NOT YOU PLAN TO ATTEND THE SPECIAL
MEETING, PLEASE COMPLETE, SIGN, DATE AND RETURN YOUR PROXY CARD AS SOON AS
POSSIBLE.

   If you have any questions or if you need assistance in voting your proxy,
please call Geraldine Moore, at (650) 813-0300.

                                          On Behalf of the Board of Directors,

                                          /s/ David P. Perry
                                          David P. Perry
                                          President and Chief Executive
                                           Officer

   The date of the proxy statement and prospectus is      , 1999. The proxy
statement and prospectus and the accompanying forms of proxy are first being
mailed to the stockholders of Chemdex and Promedix on or about      , 1999.
All information contained in the proxy statement and prospectus with respect
to Chemdex has been provided by Chemdex. All information contained in the
proxy statement and prospectus with respect to Promedix has been provided by
Promedix.

   Chemdex common stock is traded on the Nasdaq National Market under the
symbol "CMDX." On      , 1999, the closing sale price for Chemdex common stock
as reported on the Nasdaq market was $    per share.

   Neither the securities and exchange commission nor any state securities
commission has approved or disapproved of this transaction and the securities
being offered by Chemdex or determined if this proxy statement and prospectus
is truthful or criminal. Any representation to the contrary is a criminal
offense.
<PAGE>

                              CHEMDEX CORPORATION

                               ----------------

                   NOTICE OF SPECIAL MEETING OF STOCKHOLDERS
                            TO BE HELD      , 1999

To the Stockholders of Chemdex:

   NOTICE IS HEREBY GIVEN that a special meeting of the stockholders of
Chemdex Corporation, a Delaware corporation, will be held at    a.m., Pacific
Standard time, on      , 1999, at the Company's executive offices at 1500
Plymouth Street, Mountain View, California, to consider and vote upon the
following proposals:

     1. To approve the issuance of up to a maximum of 12,057,366 shares of
  Chemdex common stock for all shares of outstanding Promedix.com, Inc.
  capital stock, in connection with a merger whereby Promedix will become a
  wholly-owned subsidiary of Chemdex and Chemdex will assume Promedix's stock
  option plan

     2. To increase the number of shares of Chemdex common stock available
  for issuance under the Chemdex 1999 Employee Stock Purchase Plan by 300,000
  shares to a total of 1,050,000 shares.

     3. To increase the number of shares of Chemdex common stock available
  for issuance under the Chemdex 1998 Stock Plan by 4,250,000 shares to a
  total of 10,375,000 shares.

     4. To transact any other business that properly comes before the special
  meeting or any adjournments or postponements thereof.

   The Board of Directors has fixed the close of business on       , 1999 as
the record date for the determination of the holders of Chemdex common stock
entitled to notice of, and to vote at, the special meeting. Accordingly, only
stockholders of record at the close of business on such date are entitled to
notice of and to vote at the special meeting and any adjournment or
postponement. The affirmative vote of the holders of a majority of the shares
of Chemdex common stock represented at the special meeting, in person or by
proxy, is necessary for approval and adoption of proposals (1), (2) and (3)
above.

   Details of the proposed stock issuance, merger and other proposals, and
other important information concerning Chemdex and Promedix are more fully
described in the accompanying proxy statement and prospectus. Please give this
material your careful attention.

   ALL STOCKHOLDERS ARE CORDIALLY INVITED TO ATTEND THE SPECIAL MEETING. TO
ENSURE YOUR REPRESENTATION AT THE SPECIAL MEETING. HOWEVER, YOU ARE URGED TO
COMPLETE, DATE, SIGN AND RETURN THE ENCLOSED PROXY AS PROMPTLY AS POSSIBLE. A
POSTAGE-PAID ENVELOPE IS ENCLOSED FOR THAT PURPOSE. ANY STOCKHOLDER ATTENDING
THE SPECIAL MEETING MAY VOTE IN PERSON EVEN IF THAT STOCKHOLDER HAS RETURNED A
PROXY.

                                          By Order of the Board of Directors,

                                          Jeffrey Y. Suto
                                          Secretary

Mountain View, California
     , 1999
<PAGE>

                              PROMEDIX.COM, INC.
                     448 East Winchester Avenue, Suite 200
                          Salt Lake City, Utah 84107

                                                                         , 1999

Dear Fellow Stockholder,

   You are cordially invited to attend a special meeting of the stockholders
of Promedix.com, Inc., to be held at   a.m., local time, on       , 1999, at
the Company's executive offices.

   At the special meeting, you will be asked to consider and vote on a
proposal to approve and adopt an Agreement and Plan of Merger that Promedix
has entered into with Chemdex Corporation. The merger agreement provides for
the merger of a wholly-owned subsidiary of Chemdex with and into Promedix,
resulting in Promedix becoming a subsidiary of Chemdex and Promedix
stockholders becoming Chemdex stockholders.

   If this merger is approved, each outstanding share of Promedix common stock
and preferred stock will be converted into the right to receive a fraction of
one share of Chemdex common stock and each outstanding option and warrant to
purchase Promedix capital stock will become the right to acquire a number of
shares of Chemdex common stock at a price based on the same fraction. This
fractional amount or exchange ratio will be determined by dividing 12,057,366,
the maximum number of shares of Chemdex common stock to be issued as a result
of this merger, by the number of shares of Promedix capital stock outstanding
and the number of shares of capital stock issuable upon exercise of Promedix
options and warrants outstanding. There is no public trading market for
Promedix common stock or Promedix preferred stock. Chemdex common stock is
quoted on the Nasdaq Stock Market under the symbol "CMDX." The closing price
for Chemdex common stock reported on the Nasdaq Stock Market on       , 1999,
was $    per share.

   This is a proxy statement for each of Promedix and Chemdex and it is also
Chemdex's prospectus relating to its offering of shares of Chemdex common
stock to Promedix stockholders in the proposed merger. It contains important
information concerning Chemdex, Promedix, the terms of the proposed merger and
the conditions which must be satisfied before the merger can occur. You should
carefully consider the "Risk Factors" that are described starting on page
of this prospectus and proxy statement.

   YOUR BOARD HAS UNANIMOUSLY APPROVED THE TERMS OF THE MERGER AGREEMENT AND
HAS DETERMINED THAT THE MERGER IS IN THE BEST INTERESTS OF PROMEDIX AND ITS
STOCKHOLDERS. AFTER CAREFUL CONSIDERATION, THE BOARD UNANIMOUSLY RECOMMENDS A
VOTE "FOR" APPROVAL OF THE MERGER AGREEMENT.

   Stockholders of Promedix holding in the aggregate approximately 74.7% of
the Promedix common stock and 77.5% of the Promedix preferred stock have
agreed to vote all of their shares in favor of the adoption of the merger
agreement and approval of the merger. Consequently, adoption of the merger
agreement and approval of the merger by the Promedix stockholders is assured.

   Your vote is important regardless of the number of shares you own. We urge
you to read the enclosed materials carefully and to complete, sign and date
the enclosed proxy card and return it promptly in the enclosed prepaid
envelope, whether or not you plan to attend the special meeting of
stockholders. Your prompt cooperation and continued support of Promedix.com,
Inc. is greatly appreciated.

                                          Sincerely,

                                          William C. Klintworth, Jr.
                                          Chief Executive Officer

   Neither the Securities and Exchange Commission nor any state securities
regulator has approved or disapproved of the Chemdex common stock to be issued
under this prospectus and proxy statement or passed upon the adequacy or
accuracy of this prospectus and proxy statement. Any representation to the
contrary is a criminal offense.
<PAGE>

                              PROMEDIX.COM, INC.
                     448 East Winchester Avenue, Suite 200
                          Salt Lake City, Utah 84107

                   NOTICE OF SPECIAL MEETING OF STOCKHOLDERS
                           TO BE HELD ON      , 1999

   NOTICE IS HEREBY GIVEN that a Special Meeting of Stockholders of
Promedix.com, Inc. will be held on      , 1999, at 10:00 a.m., local time, at
the offices of Promedix.com, 448 East Winchester Avenue, Suite 2000, Salt Lake
City, Utah 84107.

   Only Promedix stockholders of record as of     , 1999 are entitled to
attend and vote at the special meeting. At the special meeting, you will be
asked to consider and vote upon the following proposal:

   To approve and adopt the Agreement and Plan of Merger dated as of September
21, 1999 by and among Chemdex, Popcorn Acquisitions Corp., a Delaware
corporation and wholly-owned subsidiary of Chemdex, and Promedix.com, Inc.,
and to approve the merger of Popcorn Acquisitions with and into Promedix
pursuant to the merger agreement. Pursuant to the merger agreement,

     (a) Popcorn Acquisitions will merge with and into Promedix,

     (b) each outstanding share of Promedix capital stock, $.0001 par value
  per share, will be converted into the right to receive a fraction of one
  share of Chemdex common stock, $.0002 par value per share, based on an
  exchange ratio which is discussed below, and

     (c) each outstanding option to purchase Promedix capital stock will be
  deemed to constitute the right to acquire, on the same terms and
  conditions, a number of shares of Chemdex common stock and prices based on
  the same exchange ratio.

   The exchange ratio for converting Promedix securities into Chemdex common
stock will be determined by dividing 12,057,366, the maximum number of shares
of Chemdex common stock to be issued as a result of this merger, by the number
of Promedix capital stock outstanding and the number of shares of capital
stock issuable upon exercise of Promedix options outstanding.

   THE BOARD OF DIRECTORS OF PROMEDIX UNANIMOUSLY RECOMMENDS THAT YOU VOTE FOR
APPROVAL AND ADOPTION OF THE MERGER AGREEMENT.

   STOCKHOLDERS OF PROMEDIX HOLDING IN THE AGGREGATE APPROXIMATELY 74.7% OF
THE PROMEDIX COMMON STOCK AND 77.5% OF THE PROMEDIX PREFERRED STOCK HAVE
AGREED TO VOTE ALL OF THEIR SHARES IN FAVOR OF THE ADOPTION OF THE MERGER
AGREEMENT AND APPROVAL OF THE MERGER. CONSEQUENTLY, ADOPTION OF THE MERGER
AGREEMENT AND APPROVAL OF THE MERGER BY THE PROMEDIX STOCKHOLDERS IS ASSURED.

   Detailed information concerning the merger agreement and the merger is
contained in the accompanying proxy statement and prospectus. We encourage you
to read this entire document carefully.

                                             For the Board of Directors,

                                             William C. Klintworth, Jr.
                                             Chief Executive Officer

Salt Lake City, Utah
      , 1999

   YOUR VOTE IS IMPORTANT REGARDLESS OF THE NUMBER OF SHARES YOU OWN. WHETHER
OR NOT YOU EXPECT TO ATTEND THE SPECIAL MEETING IN PERSON, PLEASE COMPLETE,
SIGN AND PROMPTLY RETURN THE ENCLOSED PROXY IN THE ENCLOSED POSTAGE-PREPAID
ENVELOPE. A STOCKHOLDER WHO EXECUTES A PROXY MAY REVOKE IT AT ANY TIME BEFORE
IT IS EXERCISED BY GIVING WRITTEN NOTICE OF REVOCATION TO PROMEDIX, BY
SUBSEQUENTLY DELIVERING ANOTHER PROXY OR BY ATTENDING THE SPECIAL MEETING AND
VOTING IN PERSON.

   YOU SHOULD NOT SEND STOCK CERTIFICATES WITH YOUR PROXIES. A TRANSMITTAL
LETTER FOR YOUR STOCK WILL BE SENT TO YOU BY THE EXCHANGE AGENT AFTER THE
CLOSING.
<PAGE>

<TABLE>
<S>                         <C>
   CHEMDEX CORPORATION                     PROMEDIX.COM, INC.

             ---------------                         ---------------

PROXY STATEMENT/PROSPECTUS                  PROXY STATEMENT
</TABLE>

   This proxy statement and prospectus is being furnished to the holders of
common stock of Chemdex Corporation, a Delaware corporation, in connection
with the solicitation of proxies by the Board of Directors of Chemdex for use
at the special meeting of stockholders of Chemdex to be held at Chemdex's
executive offices at 1500 Plymouth Street, Mountain View, California, on
     , 1999, commencing at    a.m., Pacific Standard time.

   This proxy statement and prospectus is also being furnished to the holders
of capital stock of Promedix.com, Inc., a Delaware corporation, in connection
with the solicitation of proxies by the Board of Directors of Promedix for use
at the special meeting of stockholders of Promedix to be held at Promedix's
executive offices at 448 East Winchester Avenue, Suite 200, Salt Lake City,
Utah on      , 1999, commencing at    a.m., Mountain Standard time.

   This proxy statement and prospectus relates to the proposed merger of
Popcorn Acquisitions Corp., a Delaware corporation and a wholly-owned
subsidiary of Chemdex, with and into Promedix, which will become a wholly-
owned subsidiary of Chemdex pursuant to an Agreement and Plan of Merger dated
as of September 21, 1999 by and among Chemdex, Popcorn and Promedix. In the
merger, each outstanding share of Promedix common stock, assuming the
conversion of all outstanding Promedix preferred stock into common stock, will
be converted into and represent the right to receive a fraction of a share of
Chemdex common stock based on an exchange ratio, and each outstanding option
and warrant to purchase Promedix capital stock will be converted into an
option and warrant, respectively, to purchase shares of Chemdex common stock
in accordance with the same exchange ratio. This exchange ratio will be
determined by dividing 12,057,366, the maximum number of shares of Chemdex
common stock to be issued as a result of this merger, by the sum of the number
of shares of Promedix capital stock outstanding and the number of shares of
capital stock issuable upon exercise of outstanding options and warrants to
purchase Promedix capital stock as of the closing date. Following the merger,
Chemdex stockholders will own approximately 75%, and Promedix stockholders
will own approximately 25%, of Chemdex.

   Consummation of the merger is subject to various conditions, including
approval of the Chemdex common stock issuance by a majority of the shares of
Chemdex common stock entitled to vote at the Chemdex special meeting and
approval of the merger agreement by the requisite majorities of the shares of
Promedix capital stock entitled to vote at the Promedix special meeting.

   Stockholders of Promedix holding in the aggregate approximately 74.7% of
the Promedix common stock and 77.5% of the Promedix preferred stock have
agreed to vote all of their shares in favor of the adoption of the merger
agreement and approval of the merger. Consequently, adoption of the merger
agreement and approval of the merger by the Promedix stockholders is assured.

   This proxy statement and prospectus also constitutes a prospectus of
Chemdex with respect to up to 12,057,366 shares of Chemdex common stock to be
issued in connection with the merger. Chemdex common stock is traded on the
Nasdaq National Market under the symbol "CMDX." On      , 1999, the closing
sale price for Chemdex common stock as reported on the Nasdaq market was $
per share.

   All information contained in this proxy statement and prospectus with
respect to Chemdex has been provided by Chemdex. All information contained in
this proxy statement and prospectus with respect to Promedix has been provided
by Promedix. This proxy statement and prospectus and the accompanying forms of
proxy are first being mailed to the stockholders of Chemdex and Promedix on or
about    , 1999. A stockholder who has given a proxy may revoke it at any time
prior to its exercise. See "The Chemdex Special Meeting--Voting and Revocation
of Proxies" and "The Promedix Special Meeting--Record Date; Voting Rights;
Proxies."

   See "Risk Factors" beginning on page 13 for a discussion of certain factors
that should be considered by Chemdex and Promedix stockholders.

   If you have any questions concerning the merger or the calculation of the
exchange ratio or if you need assistance in voting your proxy, please call
Geraldine Moore, at (650) 813-0300.

   THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES
AND EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION NOR HAS THE
COMMISSION OR ANY STATE SECURITIES COMMISSION PASSED UPON THE ACCURACY OR
ADEQUACY OF THIS PROXY STATEMENT AND PROSPECTUS. ANY REPRESENTATION TO THE
CONTRARY IS A CRIMINAL OFFENSE.

        The date of this proxy statement and prospectus is      , 1999.

     The mail date of this proxy statement and prospectus is      , 1999.
<PAGE>

                               TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                           Page
                                                                           ----
<S>                                                                        <C>
QUESTIONS AND ANSWERS ABOUT THE CHEMDEX/PROMEDIX MERGER...................  iv

SUMMARY...................................................................   1
  The Companies...........................................................   1
  The Special Meetings....................................................   1
  The Merger..............................................................   2
  Stockholder Vote Required...............................................   3
  Dissenters' Rights......................................................   3
  Tax Treatment...........................................................   3
  Interests of Officers and Directors in the Merger.......................   3
  Conditions of the Merger................................................   4
  Termination of the Merger...............................................   4
  No-Solicitation Provisions; Termination Fee and Expenses................   4
  Accounting Treatment....................................................   5
  Opinion of Chemdex's Financial Advisor..................................   5
  Indemnification and Escrow..............................................   5
  Sale of Pro Med Co., Inc................................................   5
  Certain Legal Matters...................................................   5
  Listing of Chemdex Common Stock.........................................   5
  Ownership of Chemdex Following the Merger...............................   5

SELECTED HISTORICAL CONDENSED FINANCIAL INFORMATION AND COMPARATIVE PER
 SHARE DATA...............................................................   6

SELECTED UNAUDITED COMBINED CONDENSED FINANCIAL INFORMATION...............  10

HISTORICAL AND PRO FORMA PER SHARE DATA...................................  12

RISK FACTORS..............................................................  13

FORWARD-LOOKING INFORMATION...............................................  32

THE PROMEDIX SPECIAL MEETING..............................................  33
  General; Date, Time and Place...........................................  33
  Matters to be Considered................................................  33
  Board of Directors' Recommendation......................................  33
  Record Date and Outstanding Shares......................................  33
  Solicitation of Proxies; Expenses.......................................  34
  Recommendation of the Board of Directors of Promedix....................  34

THE CHEMDEX SPECIAL MEETING...............................................  35
  General; Date, Time and Place...........................................  35
  Matters to be Considered................................................  35
  Board of Directors' Recommendation......................................  35
  Record Date and Outstanding Shares......................................  35
  Solicitation of Proxies; Expenses.......................................  35
  Board of Directors' Recommendations.....................................  36

THE MERGER................................................................  37
  Background of the Merger................................................  37
  Reasons of Promedix for the Merger; Recommendation of the Board of
   Directors of Promedix..................................................  38
  Reasons of Chemdex for the Merger; Recommendation of the Board of
   Directors of Chemdex...................................................  39
  Opinion of Financial Advisor to Chemdex.................................  40
  Interests of Certain Persons in the Merger..............................  46
  Indemnification and Escrow..............................................  47
</TABLE>

                                       i
<PAGE>

<TABLE>
<CAPTION>
                                                                           Page
                                                                           ----
<S>                                                                        <C>
  Voting Agreements.......................................................  48
  Affiliate Agreements....................................................  48
  Certain Material U.S. Federal Income Tax Consequences...................  48
  Accounting Treatment....................................................  50
  Certain Legal Matters...................................................  51
  U.S. Federal Securities Law Consequences................................  51
  Dividends...............................................................  52
  Stock Market Listing....................................................  52
  Dissenters' Rights......................................................  52

OTHER TERMS OF THE MERGER AGREEMENT.......................................  55
  Effective Time of the Merger............................................  55
  Conversion of Securities................................................  55
  Stock Options...........................................................  55
  Warrants................................................................  56
  Exchange of Shares; No Fractional Shares................................  56
  Representations and Warranties..........................................  57
  Conduct of Business by Promedix.........................................  59
  Conduct of Business by Chemdex..........................................  60
  Joint Conduct...........................................................  61
  No Solicitation.........................................................  61
  Certain Other Covenants.................................................  62
  Public Announcements....................................................  62
  Conditions to the Merger................................................  63
  Termination.............................................................  64
  Expenses; Cancellation Fees.............................................  64
  Amendment; Waiver.......................................................  64
  Management of Chemdex Upon Consummation of the Merger...................  65

COMPARATIVE STOCK PRICE DATA AND DIVIDEND HISTORY.........................  66

UNAUDITED PRO FORMA COMBINED CONDENSED FINANCIAL INFORMATION..............  67

INFORMATION ABOUT PROMEDIX................................................  77
  Promedix's Business.....................................................  77
  Promedix Selected Financial Data........................................  81
  Promedix Management's Discussion and Analysis of Financial Condition and
   Results of Operations..................................................  82
  Promedix Management.....................................................  87
  Promedix Related Party Transactions.....................................  87
  Principal Stockholders of Promedix......................................  88

INFORMATION ABOUT CHEMDEX.................................................  89
  Chemdex's Business......................................................  89
  Chemdex Selected Financial Data......................................... 105
  Chemdex Management's Discussion and Analysis of Financial Condition and
   Results of Operations.................................................. 106
  Chemdex Management...................................................... 117
  Chemdex Related Party Transactions...................................... 124
  Principal Stockholders of Chemdex....................................... 127
  Description of Chemdex Capital Stock.................................... 130

COMPARISON OF RIGHTS OF CHEMDEX STOCKHOLDERS AND PROMEDIX STOCKHOLDERS.... 131

EXPERTS................................................................... 133

CHANGE IN INDEPENDENT ACCOUNTANTS......................................... 133
</TABLE>

                                       ii
<PAGE>

<TABLE>
<CAPTION>
                                                                          Page
                                                                          ----
<S>                                                                       <C>
LEGAL MATTERS............................................................ 133

OTHER MATTERS............................................................ 133

ADDITIONAL MATTERS BEING SUBMITTED TO A VOTE OF ONLY CHEMDEX
 STOCKHOLDERS............................................................ 134
  Approval of Amendment to the 1999 Employee Stock Purchase Plan......... 134
  Description of the 1998 Employee Stock Purchase Plan................... 134
  Recommendation of the Chemdex Board of Directors....................... 135
  Approval of Amendment to the 1998 Stock Plan........................... 136
  Description of the 1998 Stock Option Plan.............................. 136
  Recommendation of the Chemdex Board of Directors....................... 138

WHERE YOU CAN FIND MORE INFORMATION...................................... 139

INDEX TO FINANCIAL STATEMENTS............................................ F-1

ANNEX A--AGREEMENT AND PLAN OF MERGER.................................... A-1

ANNEX B--ESCROW AGREEMENT................................................ B-1

ANNEX C--OPINION OF FINANCIAL ADVISOR TO CHEMDEX......................... C-1

ANNEX D--DELAWARE DISSENTERS' RIGHTS PROVISIONS.......................... D-1
</TABLE>

                                      iii
<PAGE>

            QUESTIONS AND ANSWERS ABOUT THE CHEMDEX/PROMEDIX MERGER

Q. WHY ARE CHEMDEX AND PROMEDIX PROPOSING THE MERGER?

A.Promedix's online business-to-business e-commerce services for specialty
healthcare products are complementary to Chemdex's online business-to-business
e-commerce services for life sciences products. With the greater financial and
technology resources available to Chemdex, the merger should provide a means to
enhance and accelerate significantly the development and distribution of
Promedix's products and services. The merger will also give Promedix
stockholders the opportunity to participate in a substantially larger and more
diversified publicly traded company.

Q. WHAT WILL PROMEDIX STOCKHOLDERS RECEIVE IN THE MERGER?

A.Promedix Stockholders will receive a fraction of a Chemdex common share for
each share of Promedix capital stock. This fraction is referred to as the
"exchange ratio." The exchange ratio is designed so that Promedix stockholders
and option holders will collectively own approximately 25% of Chemdex's
outstanding capital stock following the merger. Cash will be paid instead of
the distribution of fractional shares.

Q. WHAT IS THE EXCHANGE RATIO?

A.The exchange ratio will equal 12,057,366, the maximum number of shares of
Chemdex common stock being issued to the Promedix stockholders in the merger,
divided by the total number of shares of outstanding Promedix capital stock
plus shares of Promedix capital stock issuable upon exercise of outstanding
Promedix options and warrants as of the closing of the merger. Based on the
share calculations set forth in the September 30, 1999 Unaudited Pro Forma
Combined Condensed Financial Statements, each outstanding share of Promedix
capital stock would be exchanged for approximately 1.2795 shares of Chemdex
common stock. See Note 1 to Unaudited Pro Forma Combined Condensed Financial
Statements, on page 73.

Q. DOES THE BOARD OF DIRECTORS OF PROMEDIX RECOMMEND VOTING IN FAVOR OF THE
   MERGER?

A.Yes. After careful consideration, the Promedix board of directors recommends
that its stockholders vote in favor of the merger agreement and the proposed
merger.

   Stockholders of Promedix holding the requisite majority of each class and
series of Promedix capital stock have agreed to vote all of their shares in
favor of the adoption of the merger agreement and approval of the merger.
Consequently, adoption of the merger agreement and approval of the merger by
the Promedix stockholders is assured.

Q. DOES THE BOARD OF DIRECTORS OF CHEMDEX RECOMMEND VOTING IN FAVOR OF THE
   MERGER?

A.Yes. After careful consideration, the Chemdex board of directors recommends
that its stockholders vote in favor of the merger agreement, the proposed
merger and the issuance of the shares of Chemdex common stock to the
stockholders of Promedix.

Q. WHY IS PROMEDIX SELLING ITS SUBSIDIARY, PRO MED CO., INC.?

A.Pro Med Co., a wholly-owned subsidiary of Promedix, Inc., is in the business
of marketing and distributing medical equipment and supplies through its
warehouse. Chemdex provides e-commerce solutions to the life sciences market.
Together with Promedix, Chemdex intends to extend its pure Internet-based
purchasing solution to the specialty medical products market, but does not plan
to operate a distribution or fulfillment business.

Q. WHAT SHOULD I DO NOW?

A.You should cast your vote on the merger by completing, signing and dating
your proxy card. The completed proxy card should be returned in the enclosed
self-addressed postage paid envelope. You can also attend your company's
special meeting and vote in person.

                                       iv
<PAGE>

   Promedix stockholders should not send in stock certificates now. After the
merger is completed, Promedix stockholders will be sent written instructions
for exchanging their share certificates.

Q. WHEN SHOULD I SEND IN MY PROXY CARD? CAN I CHANGE MY VOTE?

A.You should send in your proxy card as soon as possible so that your shares
will be voted at the special meeting. You can change your vote at any time
prior to your company's special meeting by submitting a later dated signed
proxy card. You can also change your vote by attending your company's special
meeting and voting in person.

Q. WHEN WILL THE MERGER TAKE EFFECT?

A.The merger is expected to take effect on the date Chemdex and Promedix
stockholders each approve and adopt the merger agreement at special meetings of
each company's stockholders.

Q. WILL THE PROMEDIX STOCKHOLDERS RECOGNIZE AN INCOME TAX GAIN OR LOSS ON THE
   MERGER?

A.Promedix stockholders will not recognize gain or loss for U.S. federal income
tax purposes if the merger is completed, except Promedix stockholders will
recognize gain with respect to cash received instead of fractional shares or
received after the exercise of appraisal rights. However, all stockholders are
urged to consult their own tax advisor to determine their particular tax
consequences.

Q. WHEN WILL I RECEIVE SHARES OF CHEMDEX COMMON STOCK IN THE MERGER?

A.If the merger is completed, Chemdex will issue up to a maximum of 12,057,366
shares of Chemdex common stock to Promedix stockholders who have returned their
Promedix stock certificates together with a completed letter of transmittal
supplied by Chemdex or Chemdex's exchange agent, Boston EquiServe LP. Ninety
percent (90%) of such shares will be held in escrow until January 22, 2000, the
date the lock-up expires in connection with Chemdex's initial public offering,
so that the Promedix stockholders will not be able to begin trading their
shares before the Chemdex stockholders who purchased their shares prior to
Chemdex's initial public offering. The remaining ten percent (10%) of such
shares will be held in escrow for one year after consummation of the merger as
security of Promedix's indemnification obligations. Promedix made statements or
promises about itself, called representations and warranties, in the merger
documents. If these statements or promises turn out to be incorrect, Chemdex
may have a claim against Promedix which would be satisfied solely out of the
escrowed 10% portion of the shares.

Q. ARE THE PROMEDIX STOCKHOLDERS ENTITLED TO DISSENTERS' OR APPRAISAL RIGHTS?

A.Chemdex stockholders will not be entitled to dissenters' rights in connection
with the merger. Promedix stockholders who do not wish to accept the Chemdex
common stock to be issued in the merger have dissenters' rights, the right to
have the "fair value" of their shares determined by the Delaware Chancery
Court. However, holders of Promedix preferred stock may not be entitled to
dissenters' rights. These dissenters' rights are subject to a number of
restrictions and technical requirements. Generally, in order to exercise
dissenters' rights:

  . Promedix stockholders must not vote in favor of the merger; and

  . Promedix stockholders must make a written demand for appraisal before the
    vote on the merger.

   Merely voting against the merger will not protect Promedix stockholders'
right of appraisal. Annex D contains the text of the Delaware appraisal
statute. Please note that Chemdex has the right to abandon the transaction if
the holders of 5% or more of Promedix stock exercise their dissenters' rights.
See "Rights of Dissenting Promedix Stockholders" on page  .

Q. WHAT SHOULD I DO IF I HAVE QUESTIONS?

A.You should call Geraldine Moore at 1-650-813-0300.

                                       v
<PAGE>

                                    SUMMARY

   This summary highlights selected information from this document and may not
contain all of the information that is important to you. To better understand
the merger and for a more complete description of the legal terms of the
merger, you should read carefully this entire document and the documents to
which you have been referred. See "Where You Can Find More Information" on page
 .

The Companies

   Chemdex Corporation
   3950 Fabian Way
   Palo Alto, California 94303
   (650) 813-0300

   Chemdex is a leading provider of business-to-business e-commerce solutions
to the life sciences industry. Chemdex enables life sciences enterprises, such
as biotechnology and pharmaceutical companies and academic and research
institutions, researchers and suppliers to efficiently buy and sell research
products through the Chemdex Marketplace. The Chemdex Marketplace is a database
of laboratory research products that may be sold and purchased through a
secure, Internet-based purchasing solution. The Chemdex Marketplace utilizes an
advanced search engine and software to allow users to easily identify, locate
and purchase life sciences research products, such as chemicals and equipment
used in laboratory experiments. Chemdex was incorporated in Delaware in
September 1997.

   As used herein the term "Chemdex" refers to Chemdex Corporation and its
subsidiaries, unless the context otherwise requires. For additional information
regarding the business of Chemdex, please see "Where to Find More Information"
on page 139 and "Information about Chemdex" on page 89, and Chemdex's Form S-1,
Form 10-Q and other filings of Chemdex with the SEC.

   Promedix.com, Inc.
   488 East Winchester Avenue, Suite 200
   Salt Lake City, UT 84107
   (800) 453-1264

   Based in Salt Lake City, Utah, Promedix is a leading provider of business-
to-business e-commerce solutions to the specialty healthcare products industry.
Promedix enables healthcare enterprises, such as hospitals and surgery centers
to efficiently buy and sell specialty healthcare products online. Promedix
maintains a database of specialty healthcare products that may be sold and
purchased through a secure, Internet-based purchasing solution. Promedix was
incorporated in Utah in December 1996.

   On November 9, 1999, Promedix agreed to sell all of the outstanding shares
of capital stock of Pro Med Co., Inc., a Utah corporation and a wholly-owned
subsidiary of Promedix, to an unrelated third party. The sale will be completed
prior to the closing of the merger. Pro Med Co. is in the business of marketing
and distributing medical equipment and supplies and is referred to herein as
the "fulfillment business." As a result of such sale, Promedix will no longer
own or operate the fulfillment business.

   For additional information regarding the business of Promedix, please see
"Information about Promedix" beginning on page 77.

The Special Meetings

   Time, Place and Date. A special meeting of stockholders of Chemdex will be
held at Chemdex's executive offices at 1500 Plymouth Street, Mountain View,
California, on      , 1999 at   a.m., Pacific

                                       1
<PAGE>

Standard time. A special meeting of stockholders of Promedix will be held at
Promedix's executive offices at 448 East Winchester Avenue, Suite 200, Salt
Lake City, Utah, on      , 1999 at   a.m., Mountain Standard time.

   Purpose of the Special Meetings. At the Chemdex special meeting, holders of
Chemdex common stock will be asked to consider and vote upon the following
proposals to approve: (1) the issuance of up to a maximum of 12,057,366 shares
of Chemdex common stock in connection with the merger of Promedix and a wholly-
owned subsidiary of Chemdex described below; (2) an increase in the number of
shares available under the 1999 Employee Stock Purchase Plan by 300,000 shares
to a total of 1,050,000 shares; and (3) an increase in the number of shares
available under the 1998 Stock Plan by 4,200,000 shares to a total of
10,375,000 shares. At the Promedix special meeting, holders of Promedix common
stock will be asked to consider and vote upon a proposal to approve the merger
agreement.

   Votes Required; Record Dates. The holders of a majority of the outstanding
shares of Chemdex common stock entitled to vote at the Chemdex special meeting
must approve the common stock issuance in connection with the merger and the
other proposals. Holders of Chemdex common stock are entitled to one vote per
share. Only holders of Chemdex common stock at the close of business on the
record date,      , 1999, are entitled to notice of and to vote at the Chemdex
special meeting.

   The holders of a majority of the outstanding shares of Promedix preferred
stock entitled to vote at the Promedix special meeting and the holders of a
majority of the outstanding shares of Promedix common stock entitled to vote at
the Promedix special meeting, voting both together and separately as two
classes, must also approve the merger. Holders of Promedix capital stock are
entitled to one vote per share. Only holders of Promedix capital stock at the
close of business on the record date,     , 1999 are entitled to notice of and
to vote at the Promedix special meeting. Promedix stockholders holding in
aggregate approximately 74.7% of the outstanding Promedix common stock and
77.5% of the outstanding Promedix preferred stock have signed voting agreements
requiring them to vote all of their shares in favor of the adoption of the
merger agreement. Consequently, adoption of the merger agreement and approval
of the merger by Promedix is assured.

   Voting; Proxies. Chemdex stockholders can vote shares by attending the
Chemdex special meeting and voting in person or by signing and mailing the
enclosed proxy card with their votes. Chemdex stockholders can revoke their
proxy at any time before the vote is taken. Promedix stockholders can vote
shares by attending the Promedix special meeting and voting in person or by
signing and mailing the enclosed proxy card with their votes. Stockholders can
revoke their proxy at any time before the vote is taken.

The Merger (Page 37)

   If the merger is completed, a wholly-owned subsidiary of Chemdex formed for
the purpose of the merger will merge with Promedix, Promedix will continue as
the surviving entity and will become a wholly-owned subsidiary of Chemdex, and
Chemdex will issue up to a maximum of 12,057,366 shares of its common stock in
exchange for all of the Promedix capital stock outstanding, and issuable upon
exercise of all Promedix convertible securities outstanding, on the closing
date of the merger.

   Upon completion of the merger, the former holders of Promedix capital stock
and securities convertible into Promedix capital stock will own approximately
25% of the fully diluted securities of the combined company. The exact number
of shares of Chemdex common stock that will be exchanged for Promedix
securities will not be known at the time you vote on the merger because the
exchange ratio depends on the number of fully diluted shares of Promedix
capital stock outstanding immediately prior to the merger. Based on the number
of fully diluted shares of capital stock outstanding as of September 30, 1999,
Chemdex would issue approximately 1.2795 shares of its common stock for each
share of Promedix common stock.

                                       2
<PAGE>


Stockholder Vote Required (Pages 33 and 35)

   To approve the Chemdex stock issuance in connection with the merger, the
holders of a majority of the outstanding shares of Chemdex common stock
represented at the special meeting, in person or by proxy, must vote for the
common stock issuance. To approve the increase in the number of shares of
Chemdex common stock available for issuance under the Chemdex 1999 Employee
Stock Purchase Plan, the holders of a majority of the outstanding shares of
Chemdex common stock represented at the special meeting, in person or by proxy,
must vote for the increase. To approve the increase in the number of shares of
Chemdex common stock available for issuance under the Chemdex 1998 Stock Plan,
the holders of a majority of the outstanding shares of Chemdex common stock
represented at the special meeting, in person or by proxy, must vote for the
increase.

   The holders of a majority of the outstanding shares of Promedix preferred
stock, the holders of a majority of the outstanding shares of Promedix common
stock and the holders of a majority of all the outstanding shares (preferred
and common combined) of Promedix stock must vote for the approval and adoption
of the merger agreement to approve the merger.

   Stockholders of Promedix holding in the aggregate approximately 74.7% of the
Promedix common stock and 77.5% of the Promedix preferred stock have agreed to
vote all of their shares in favor of the adoption of the merger agreement and
approval of the merger. Consequently, adoption of the merger agreement and
approval of the merger by the Promedix stockholders is assured.

Dissenters' Rights (Page 52)

   Under Delaware law, any Promedix stockholder who does not wish to accept the
consideration provided for in the merger agreement is entitled to exercise
dissenters' rights. Such rights entitle the stockholder to require Promedix to
purchase the dissenting shares for cash at their fair market value, excluding
any element of value arising from the accomplishment or expectation of the
merger.

   Annex D contains the pertinent provisions of Delaware law addressing
dissenters' rights. Any Promedix stockholder intending to exercise statutory
dissenter's rights is urged to review Annex D carefully and to consult with
legal counsel so as to assure strict compliance with its provisions.

   A vote in favor of the merger agreement and the merger will constitute a
waiver of your dissenters' right. For further information regarding dissenters'
rights, see "The Merger--Dissenters' Rights."

Tax Treatment (Page 48)

   It is anticipated that the merger will constitute a "reorganization" for
federal income tax purposes and, accordingly, that no gain or loss will be
recognized by Promedix stockholders (except with respect to cash received by
dissenting stockholders or in lieu of fractional shares), Chemdex stockholders,
Chemdex or Promedix as a result of the merger. Consummation of the merger is
conditioned upon the delivery of opinions of counsel to this effect. See "The
Merger--Certain Material U.S. Federal Income Tax Consequences" and "Other Terms
Of The Merger Agreement--Conditions To The Merger."

Interests of Officers and Directors in the Merger (Page 46)

   In considering the recommendation of the Promedix board of directors in
favor of the merger, stockholders should be aware that members of the Promedix
board and Promedix management will receive benefits as a result of the merger
that will be in addition to or different from benefits received by Promedix
stockholders generally. See "Interests of Certain Persons in the Merger."

                                       3
<PAGE>


Conditions of the Merger (Page 63)

   The consummation of the merger depends upon satisfaction of a number of
conditions, including:

  . approval and adoption of the merger agreement by the Chemdex and Promedix
    stockholders;

  . receipt of all necessary government authorizations and consents;

  . the absence of legal restraints to the consummation of the merger;

  . approval for quotation by the Nasdaq Stock Market of the shares to be
    issued in the merger;

  . effectiveness of the registration statement filed in connection with the
    shares to be issued in the merger;

  . receipt of opinions regarding the tax-free nature of the merger in
    respect of the Chemdex common shares received;

  . expiration of the waiting period applicable to the merger under the Hart-
    Scott-Rodino Antitrust Improvements Act;

  . execution and delivery of certain ancillary agreements, including an
    escrow agreement;

  . receipt of legal opinions;

  . resignation of the Promedix directors and appointment of William C.
    Klintworth, Jr. to the Chemdex board of directors;

  . sale of Promedix's Pro Med Co. subsidiary; and

  . conversion or repayment of all of Promedix's convertible debt.

Termination of the Merger (Page 64)

   Either Promedix or Chemdex may call off the merger if:

  . both parties consent in writing;

  . a court or government agency prohibits the merger;

  . the other company breaches in a material way its representations,
    warranties, covenants or agreements and that breach is not remedied
    within 10 business days or cannot be remedied;

  . the merger does not close before February 29, 2000 because the other
    company's stockholders do not approve the merger, or due to a failure of
    any of the conditions listed above applicable to both parties or to the
    other company's failure to satisfy its closing obligations; or

  . the other party's board of directors recommends an alternative
    transaction meeting certain criteria specified in the merger agreement.

   For further details, see "Termination."

No-Solicitation Provisions; Termination Fee and Expenses (Page 64)

   Promedix and Chemdex each agreed that it will not solicit or encourage the
initiation of any inquiries or proposals regarding any alternative acquisition
transactions with third parties. Each company may respond to unsolicited
transaction proposals if required by the fiduciary duties of its board of
directors. Each company must promptly notify the other if it receives proposals
for any alternative acquisition transactions. If the merger is terminated under
specified circumstances, generally involving an alternative acquisition
transaction, Chemdex or Promedix may be required to pay the other a
cancellation fee of $10 million.

   See "Expenses; Cancellation Fees" for a discussion of the circumstances in
which the cancellation fee is payable. The cancellation fee and the no-
solicitation provisions may have the effect of discouraging persons

                                       4
<PAGE>

who might be interested in entering into an acquisition transaction with
Promedix from proposing an alternative acquisition transaction.

Accounting Treatment (Page 50)

   The merger will be accounted for as a purchase by Chemdex in accordance with
United States generally accepted accounting principles.

Opinion of Chemdex's Financial Advisor (Page 40)

   In determining that the merger is fair to and in the best interests of
Chemdex and its stockholders, the Chemdex board considered an opinion from its
financial advisor, Morgan Stanley & Co. Incorporated, that, as of the date of
such opinion, the consideration issued by Chemdex pursuant to the merger
agreement is fair from a financial point of view. See "Opinion of Financial
Advisor to Chemdex." The full text of the written opinion of Morgan Stanley is
attached as Annex C. YOU SHOULD READ THIS OPINION.

Indemnification and Escrow (Page 47)

   If the merger agreement is approved and the merger occurs, all holders of
Promedix capital stock who have not perfected dissenter's rights under Delaware
law, by their receipt of Chemdex common stock in the merger, will be deemed to
have agreed personally to indemnify Chemdex, the surviving corporation of the
merger and its affiliates against losses due to the breach of any of Promedix's
representations, warranties or agreements in the merger agreement that occurs
or becomes known to Chemdex within one year of the closing in excess of
$150,000. This obligation to indemnify Chemdex is limited to no more than 10%
of the total number of shares of Chemdex common stock issued in the merger. An
escrow arrangement will be established at closing to hold these shares of
Chemdex common stock. The escrow agreement is attached as Annex B to this proxy
statement. The escrow and indemnification obligations will end one year after
closing. At that time, if Chemdex has not made a claim for the escrowed shares,
the escrowed shares will be released to the former Promedix stockholders. See
"Indemnification and Escrow."

Sale of Pro Med Co., Inc. (Page 78)

   On November 9, 1999, Promedix agreed to sell all of the outstanding shares
of capital stock of Pro Med Co., Inc., a Utah corporation and wholly-owned
subsidiary of Promedix, to an unrelated third party. The sale will be completed
prior to the closing of the merger. See "Sale of Pro Med Co., Inc."

Certain Legal Matters (Page 51)

   U.S. antitrust laws may prohibit Chemdex and Promedix from completing the
merger until each has furnished information to the Antitrust Division of the
U.S. Department of Justice and Federal Trade Commission and a required waiting
period has ended. See "Certain Legal Matters."

Listing of Chemdex Common Stock (Page 130)

   The shares of Chemdex common stock issued in connection with the merger will
be quoted on the Nasdaq National Market.

Ownership of Chemdex Following the Merger

   Upon completion of the merger, existing Chemdex stockholders and option
holders will own approximately 75%, and former Promedix stockholders and option
holders will own approximately 25%, of the fully diluted securities of Chemdex.

                                       5
<PAGE>

              SELECTED HISTORICAL CONDENSED FINANCIAL INFORMATION
                         AND COMPARATIVE PER SHARE DATA

   The tables on the following three pages present selected historical
condensed financial information and comparative per share data for Chemdex
Corporation, Promedix.com, Inc. and Pro Med Co., Inc. This information has been
derived from their respective financial statements and notes, which are
included in this proxy statement and prospectus.

   The financial information of Chemdex and Promedix, except for the interim
financial information dated September 30, 1999 and 1998, has been derived from
audited financial statements. The financial information of Pro Med Co. has been
derived from audited financial statements.

   All unaudited financial information presented has been derived from
unaudited financial statements, and in the opinion of Chemdex's and Promedix's
management reflects all normal recurring adjustments necessary for a fair
presentation.

                                       6
<PAGE>

               CHEMDEX CORPORATION SELECTED FINANCIAL INFORMATION
                     (In thousands, except per share data)

<TABLE>
<CAPTION>
                                                              Nine Months
                             September 4, 1997              Ended September
                                (Inception)     Year Ended  30, (unaudited)
                                  through      December 31, -----------------
                             December 31, 1997     1998      1998      1999
                             ----------------- ------------ -------  --------
                                  (in thousands, except per share data)
<S>                          <C>               <C>          <C>      <C>
Statements of Operations
 Data:
Net revenues................      $  --          $    29    $     4  $ 11,561
Operating loss..............        (403)         (8,796)    (4,298)  (34,790)
Net loss....................        (403)         (8,488)    (4,090)  (33,313)
Basic and diluted net loss
 per share..................      $(0.24)        $ (4.79)   $ (2.37) $  (3.33)
Weighted average common
 shares-basic and diluted...       1,704           1,772      1,724    10,007
</TABLE>

<TABLE>
<CAPTION>
                                                   December 31,  September 30,
                                                   -------------     1999
                                                    1997   1998   (unaudited)
                                                   ------ ------ -------------
                                                         (in thousands)
<S>                                                <C>    <C>    <C>
Balance Sheet Data:
Cash and cash equivalents......................... $1,346 $5,990   $125,563
Working capital...................................  1,116  4,490    117,913
Total assets......................................  1,728  8,168    154,795
Long-term debt and capital lease obligations, net
 of current portion...............................      6    --         590
Total liabilities.................................    280  1,820     15,582
Total stockholders' equity........................  1,448  6,348    139,213
</TABLE>

                                       7
<PAGE>

               PROMEDIX.COM, INC. SELECTED FINANCIAL INFORMATION
                     (In thousands, except per share data)

<TABLE>
<CAPTION>
                                                                Nine Months
                                                                   Ended
                                                               September 30,
                                      Year Ended   Year Ended   (unaudited)
                                     December 31, December 31, ---------------
                                         1997         1998      1998    1999
                                     ------------ ------------ ------  -------
                                      (In thousands, except per share data)
<S>                                  <C>          <C>          <C>     <C>
Statements of Operations Data:
Net revenues........................     $ 197       $   14     $  14  $ 7,876
Operating loss......................      (135)         (60)      (54)  (6,636)
Loss before extraordinary item......      (141)         (60)      (54)  (6,806)
Extraordinary item..................       --            86        86      --
Net Income (loss)...................      (141)          26        32   (6,806)
Basic net income (loss) per share:
  Loss before extraordinary item....    $(0.10)      $(0.02)   $(0.02) $ (1.94)
  Extraordinary item................    $  --         $0.03    $ 0.03   $  --
  Net income (loss).................    $(0.10)       $0.01    $ 0.01  $ (1.94)
  Weighted average common shares....     1,380        2,696     2,448    3,502
Diluted net income (loss) per share
  Loss before extraordinary items...    $(0.10)      $(0.01)   $(0.02) $ (1.94)
  Extraordinary item................    $  --        $ 0.01    $ 0.03   $  --
  Net income (loss).................    $(0.10)       $ --     $ 0.01  $ (1.94)
  Weighted average common shares....     1,380        6,693     2,448    3,502
</TABLE>

<TABLE>
<CAPTION>
                                                       December
                                                          31,      September 30,
                                                      ------------     1999
                                                      1997   1998   (unaudited)
                                                      ----  ------ -------------
                                                           (In thousands)
<S>                                                   <C>   <C>    <C>
Balance Sheet Data:
Cash and Cash equivalents............................ $127  $3,002    $  987
Working capital......................................  (24)  3,001      (670)
Total assets.........................................   20   3,035     9,158
Preferred Stock--Series A............................  --    3,002     3,738
Total liabilities and preferred stock................   41   3,033     9,786
Total stockholders' equity (deficit).................  (21)      2      (628)
</TABLE>

                                       8
<PAGE>

                PRO MED CO., INC. SELECTED FINANCIAL INFORMATION
                     (In thousands, except per share data)

<TABLE>
<CAPTION>
                                                Year Ended December 31,
                                        ---------------------------------------
                                         1994    1995    1996    1997    1998
                                        ------- ------- ------- ------- -------
<S>                                     <C>     <C>     <C>     <C>     <C>
Statements of Operations Data:
Net revenues..........................  $12,062 $14,778 $15,153 $18,019 $19,355
Operating income......................      517     741     784     685     857
Net income............................      304     544     442     335     469
Basic and diluted net loss per share..  $  3.04 $ 10.51 $  8.54 $  6.47 $  9.07
Weighted average common shares--basic
 and diluted..........................      100      52      52      52      52

Balance Sheet Data:
Cash and cash equivalents.............  $   548 $    34 $   --  $   --  $   --
Working capital.......................    4,240   1,128   1,419   1,271   1,578
Total assets..........................    3,166   3,436   4,528   5,028   5,166
Long-term debt and capital lease
 obligations, net of current portion..      208     689   1,203     789     771
Total liabilities.....................    1,600   2,597   3,247   3,413   3,285
Total stockholders' equity............    1,566     839   1,281   1,615   1,881
</TABLE>

                                       9
<PAGE>

     SELECTED UNAUDITED PRO FORMA COMBINED CONDENSED FINANCIAL INFORMATION

   The following selected unaudited pro forma combined financial information
for Chemdex is derived from the Unaudited Pro Forma Combined Condensed
Statements of Operations for the nine months ended September 30, 1999 and for
the year ended December 31, 1998 and the Unaudited Pro Forma Combined Condensed
Balance Sheet as of September 30, 1999 included elsewhere in this proxy
statement and prospectus. These pro forma financial statements give effect to
Chemdex's acquisition of Promedix through a merger and exchange of shares. The
exchange ratio will be determined by dividing 12,057,366, the maximum number of
shares of Chemdex common stock to be issued as a result of this merger, by the
sum of the number of shares of Promedix capital stock outstanding and the
number of shares of capital stock issuable upon exercise of outstanding options
and warrants to purchase Promedix capital stock as of the closing date. In
addition, the pro forma financial statements give effect to (i) the sale by
Promedix of its subsidiary, Pro Med Co., (ii) the repayment and conversion of
Promedix's subordinated convertible notes, and charge related to the
subordinated convertible notes discount, (iii) the conversion of Promedix's
redeemable convertible preferred stock to common stock, (iv) the charge related
to the reduction and acceleration of options held by Pro Med Co. employees and
two officers, and (v) the sale of Promedix Series C preferred stock subsequent
to September 30, 1999.

   The Unaudited Pro Forma Combined Condensed Statements of Operations for the
year ended December 31, 1998 and for the nine months ended September 30, 1999
reflect these transactions as if they had taken place on January 1, 1998 and
January 1, 1999, respectively. The Unaudited Pro Forma Combined Condensed
Balance Sheet gives effect to these transactions as if they had taken place on
September 30, 1999.

   The Unaudited Pro Forma Combined Condensed Statements of Operations combined
Chemdex's historical results of operations for the year ended December 31, 1998
and the unaudited nine months ended September 30, 1999 with Promedix historical
results of operations for the year ended December 31, 1998 and the unaudited
nine months ended September 30, 1999.

   The Chemdex pro forma statements are based upon information set forth in
this proxy statement and prospectus and assumptions included in the
accompanying notes. After consummation of the merger, Chemdex anticipates
completion of the valuations and other studies of the significant assets,
liabilities and business operations of Promedix. Using this information,
Chemdex will make a final purchase price allocation between tangible assets and
liabilities, identifiable intangible assets and goodwill. The impact of these
changes, principally affecting intangible assets and related amortization,
could be material.

   If the merger is approved, the merger will be accounted for using the
purchase method of accounting. Accordingly, Chemdex's cost to acquire Promedix
is calculated to be $315,776,410 assuming a Chemdex common stock price of
$26.125 per share, which is the average of the closing price per share during
the period beginning three days before and ending three days after September
21, 1999, the day the merger was announced. The cost to acquire Promedix will
be allocated to the assets acquired and liabilities assumed according to their
respective fair values, with the excess purchase price being allocated to
goodwill. As noted above, the final allocation of the purchase price is
dependent upon valuations and other studies that are not yet complete.
Accordingly, the purchase price allocation adjustments made in connection with
the development of the Chemdex Pro Forma Statements are preliminary and have
been made solely for the purpose of developing the Chemdex Pro Forma
Statements.

   The $312,296,316 pro forma excess of purchase price over net tangible assets
acquired as of September 30, 1999 is being amortized over a period of two to
three years at a rate of $104,332,105 per year. Goodwill is being amortized
over a three-year life which Chemdex believes is responsive to the rapid rate
of change in the Internet industry and is consistent with other recent mergers
of a comparable nature.

                                       10
<PAGE>


   As a result of Promedix's sale of Pro Med Co., Promedix expects to incur a
loss of $1,390,260 on the sale of Pro Med Co. and incur a charge of $3,201,686
related to the reduction and acceleration of options held by Pro Med Co.
employees and two officers. In addition, Promedix expects to incur a charge of
$2,699,163 for the discount on the subordinated convertible notes when these
notes are repaid or converted. These one-time charges will occur prior to the
consummation of the Promedix merger and will therefore be reflected on
Promedix's financial statements. The Promedix Balance Sheet After Sale of Pro
Med Co. included in the Unaudited Pro Forma Combined Condensed Balance Sheet
includes the effect of these charges. However, the Unaudited Pro Forma Combined
Condensed Statements of Operations do not reflect these one-time charges.

   The Chemdex Pro Forma Financial Statements should be read in conjunction
with the related notes included in this document and the audited and unaudited
financial statements and notes of Chemdex, Promedix and Pro Med Co., included
elsewhere in this document.

   The Chemdex Pro Forma Statements are not necessarily indicative of what the
actual financial results of the combined company would have been had the
transactions described above taken place on January 1, 1998, January 1, 1999 or
September 30, 1999, nor do they purport to indicate results of future
operations.

                     Selected Unaudited Pro Forma Combined
                            Condensed Financial Data
                     (In thousands, except per share data)

<TABLE>
<CAPTION>
                                              Year ended     Nine months ended
                                           December 31, 1998 September 30, 1999
                                           ----------------- ------------------
   <S>                                     <C>               <C>
   Statement of Operations Data
   Revenues..............................      $      43         $  11,561
   Total costs and expenses..............        113,232           131,510
   Operating loss........................       (113,189)         (119,949)
   Net loss before extraordinary item....       (112,880)         (121,273)
   Net loss..............................       (112,794)         (121,273)
   Basic and Diluted net loss per share
    before extraordinary item............      $  (21.62)        $   (8.37)
   Basic and Diluted net loss per share..      $  (21.60)        $   (8.37)
   Shares used in computing basic and
    diluted net loss per share...........          5,221            14,488
   Balance Sheet Data (at end of period)
   Total Assets..........................                          474,033
   Total Stockholders' Equity............                          453,989
   Book value per share..................                        $   10.13
</TABLE>

                                       11
<PAGE>

                    HISTORICAL AND PRO FORMA PER SHARE DATA

   The table below presents historical per share financial information for
Chemdex and Promedix. This information should be read in conjunction with the
audited financial statements and unaudited interim financial statements and the
notes thereto of Chemdex and Promedix which are included in this document. In
addition, it is important that you read the Selected Unaudited Pro Forma
Combined Condensed Financial Statements included in this document. However, pro
forma information is not necessarily indicative of what the actual financial
results would have been had the Promedix merger taken place on September 30,
1999, January 1, 1999 or January 1, 1998, nor do they purport to indicate
results of future operations.

<TABLE>
<CAPTION>
                                                                Nine Months
                                              Year Ended           Ended
                                               or as of           or as of
                                           December 31, 1998 September 30, 1999
                                           ----------------- ------------------
<S>                                        <C>               <C>
Historical--Chemdex
  Basic and diluted net loss per share....      $ (4.79)           $(3.33)
  Book value per share....................      $  0.41            $ 4.25

Historical--Promedix
  Basic loss before extraordinary item per
   share..................................      $ (0.02)           $(1.94)
  Basic extraordinary item per share......      $  0.03            $ 0.00
  Basic net income (loss) per share.......      $  0.01            $(1.94)
  Diluted loss before extraordinary item
   per share..............................      $ (0.01)           $(1.94)
  Diluted extraordinary item per share....      $  0.01            $ 0.00
  Diluted income (loss) per share.........      $  0.00            $(1.94)
  Book value per share....................      $  0.00            $(0.18)

Pro forma combined net loss per share
  Pro forma combined net loss per Chemdex
   share..................................      $(21.62)           $(8.37)
  Equivalent pro forma net loss per
   Promedix share.........................      $(16.90)           $(6.54)

Pro forma combined book value per share
  Pro forma book value per Chemdex share..                         $10.13
  Equivalent pro forma book value per
   Promedix share.........................                         $ 7.92
</TABLE>

                                       12
<PAGE>

                                  RISK FACTORS

   The following risk factors should be considered by stockholders of Chemdex
and Promedix in evaluating whether to approve the Merger Agreement. The risks
associated with the combined company in the merger will be additional risks
faced by both the Chemdex stockholders and the Promedix stockholders following
the merger. The risks described which are currently specific to Promedix will
be additional risks faced by the Chemdex stockholders, and the risks currently
specific to Chemdex will be additional risks faced by the Promedix stockholders
following the merger. These factors should be considered in conjunction with
the other information included in this Proxy statement and prospectus.

 Risks Related to the Merger

There are uncertainties associated with the integration of Promedix

   The merger involves the integration of Promedix into Chemdex. Among the
factors considered by the Chemdex board and Promedix board in connection with
their approval of the Merger Agreement were the opportunities for operating
efficiencies that they expect will ultimately result from the merger. The
integration of Promedix's operations into Chemdex following the merger will
require the dedication of management resources in order to achieve the
anticipated operating efficiencies of the merger. No assurance can be given
that difficulties encountered in integrating the operations of Promedix into
Chemdex will be overcome or that the benefits expected from such integration
will be realized. The difficulties of combining the Promedix operations into
Chemdex are exacerbated by the necessity of coordinating geographically
separated organizations, integrating personnel with disparate business
backgrounds and combining different corporate cultures. The process of
integrating operations could cause an interruption of, or loss of momentum in,
the activities of the combined company's business, including the business
acquired in the merger. Difficulties encountered or additional costs incurred
in connection with the merger and the integration of the operations of Promedix
could have an adverse effect on the business, results of operations or
financial condition of the combined company.

The issuance of Chemdex common stock in the merger may result in dilution for
stockholders

   Although the companies believe that beneficial synergies will result from
the merger, there can be no assurance that the combining of the two companies'
businesses, even if achieved in an efficient, effective and timely manner, will
result in combined results of operations and financial condition superior to
what would have been achieved by each company independently, or as to the
period of time required to achieve such result. The issuance of Chemdex common
stock in connection with the merger may have the effect of increasing Chemdex's
net loss per share from levels otherwise expected and could reduce the market
price of the Chemdex common stock unless revenue growth or cost savings and
other business synergies sufficient to offset the effect of such issuance can
be achieved.

The Promedix stockholders will be relinquishing control over Promedix

   As a result of the merger, the stockholders of Promedix will effectively
relinquish direct control over the business of Promedix. Promedix will become a
wholly-owned subsidiary of Chemdex, and thus, the continuing interest of the
Promedix stockholders in the business and financial condition of Chemdex will
be an indirect interest, as stockholders of Chemdex. As Chemdex stockholders,
Promedix stockholders will be entitled to vote on all matters submitted to a
vote by the Chemdex stockholders, together with all other Chemdex stockholders.
The Promedix stockholders will lose the separate right to vote on any matter
relating to the business of Promedix after the merger.

   As a consequence of the merger, Promedix stockholders will lose the chance
to invest in the development and exploitation of Promedix's business on a
stand-alone basis. Additionally, the combined company will have different
management than Promedix's current management, and consequently the management
of the combined

                                       13
<PAGE>

company may make strategic and operational decisions that differ from those of
Promedix's current management. It is possible that Promedix, if it remained
independent, could achieve economic performance superior to that of the
combined company. Consequently, there can be no assurance that stockholders of
Promedix would not achieve greater returns on investment if Promedix were to
remain an independent company.

The combined company will need to manage its growth and may also need to manage
additional integration challenges

   Since inception, Chemdex has experienced expansion of its operations that
has placed significant demands on Chemdex's administrative, operational and
financial resources, which demands are expected to intensify as a result of the
merger. To manage future growth, if any, the combined company must improve its
financial and management controls, reporting systems and procedures on a timely
basis and expand, train and manage its work force. There can be no assurance
that the combined company will be able to perform such actions successfully.
The combined company intends to continue to invest in improving its financial
systems and controls in connection with higher levels of operations. In the
future, the combined company may make additional acquisitions of complementary
companies, products or technologies. Managing acquired businesses entails
numerous operational and financial risks, including difficulties in
assimilating acquired operations, diversion of management's attention to other
business concerns, amortization of acquired intangible assets and potential
loss of key employees or customers of acquired operations. There can be no
assurance that the combined company will be able to effectively achieve growth,
or manage any such growth, and failure to do so could have a material adverse
effect on the combined company's operating results.

Chemdex and Promedix have limited operating histories, which makes it difficult
for you to evaluate the combined business and prospects

   Chemdex was founded in September 1997. Promedix was founded in December,
1996 and for its first two years provided Web design and hosting services for
specialty medical manufacturing clients. Promedix's current strategy--providing
a Java-based product research and purchasing system--is being developed and has
yet to generate any significant revenue. Both companies have limited operating
histories. The combined company will face risks and difficulties as an early
stage company in new and rapidly evolving markets. Some of these specific risks
and difficulties include the following:

  . we may be unable to significantly increase and maintain customer adoption
    and use of our Internet-based purchasing solution;

  . we depend substantially on a purchasing solution that has been present in
    the market for a limited time and may not be successful;

  . we may be unable to develop and enhance the Chemdex and Promedix brands;

  . we may be unable to maintain existing or establish new relationships with
    suppliers of life sciences research products and specialty medical
    products;

  . we will depend substantially on revenues from product sales and we may be
    unable to significantly increase revenues from product sales or generate
    revenues from other sources;

  . we may be unable to adapt to rapidly changing technologies and developing
    markets;

  . we may be unable to effectively manage our rapidly expanding operations
    and the increasing use of our services;

  . we may be unable to attract, retain and motivate qualified personnel,
    particularly people who understand specialized life sciences research
    products, specialty healthcare products or the life sciences and
    healthcare industries in general;

  . we may be unable to compete in a highly competitive market dominated by
    larger, more established companies with substantial financial resources
    and significant customer relationships; and

                                       14
<PAGE>

  . we may be unable to comply with applicable laws and regulations to
    economically compete in a highly competitive market.

   In 1998, Chemdex generated revenues of $29,000 and Promedix generated
revenues of $14,000. In the nine months ended September 30, 1999 Chemdex
generated revenues of $11.6 million. During that same nine month period
Promedix generated revenues of $7.9 million, although all of Promedix's
revenues are attributable to Pro Med Co., Inc., which is scheduled to be sold
prior to merger. Promedix has never earned any revenues from its Specialty
Medical Product Exchange, which is in the development stage. Due to the two
companies' limited operating histories, we believe that period-to-period
comparisons of the combined company's revenues and results of operation are not
meaningful. As a result, you should not rely on revenues or results of
operations for any prior period as an indication of future performance or
prospects.

 Risks Related to the Combined Entity

Both companies have a history of losses and anticipate continued losses for the
foreseeable future

   Both companies have had substantial losses since inception. We currently
expect the combined company's losses to increase in the future and we cannot
assure you that the combined company will ever achieve or sustain
profitability. The extent of these losses in the future will be contingent, in
part, on the amount of growth in revenue. The extent of these losses in the
future will also be contingent, in part, on the amount of growth in operating
expenses, which the combined company plans to increase. As of September 30,
1999, Chemdex had an accumulated deficit of approximately $42.2 million, and
Promedix had an accumulated deficit of approximately $6.9 million. If revenues
fail to grow at anticipated rates or operating expenses increase without a
commensurate increase in revenues, or the combined company fails to adjust
operating expense levels accordingly, the imbalance between revenues and
operating expenses will negatively affect the combined company's business,
revenues, results of operations and financial condition. The combined company's
pro forma historical financial information is of limited value in projecting
future operating results because of the lack of an operating history as a
combined organization and the emerging nature of its markets.

   To date, the two companies have derived revenues primarily from product
sales. In order to increase the combined company's revenues, we must, among
other things:

  . attract new enterprise customers and retain existing enterprise
    customers;

  . encourage users employed by our enterprise customers to adopt our
    Internet-based purchasing solution and to use it frequently;

  . increase our product offering by adding and maintaining supplier
    relationships; and

  . develop new sources of revenues beyond our existing revenue sources.

   If we are unable to accomplish one or more of these objectives, our revenues
may not grow as we anticipate, if at all, and our business, revenues, financial
condition and results of operations will be negatively affected. We may not be
able to build on our current sources of revenues by adding additional products
or services. Even if we do add additional products or services, there are
economic, legal, regulatory and other risks associated with adding these new
revenue sources. For example, we may post advertisements on our web site to
generate advertising revenue. However, our supplier relationships may be harmed
if our suppliers associate advertisements posted on our web site with a bias in
our offering of life sciences research products or specialty healthcare
products.

The combined company's business model is not proven and may not be successful

   The combined company's business-to-business e-commerce model is based on the
development of the Chemdex Marketplace for the purchase and sale of life
sciences research products and the Promedix

                                       15
<PAGE>

marketplace for specialty medical products. This business model is new and not
proven and depends upon our ability to, among other things:

  . sell our purchasing solution to pharmaceutical and biotechnology
    companies, hospitals and other healthcare providers, and academic and
    research institutions;

  . achieve high rates of adoption by users within life sciences and
    healthcare enterprise customers;

  . maintain our current suppliers and enter into agreements with additional
    suppliers;

  . generate significant revenues from the use of our Internet-based
    purchasing solution; and

  . obtain higher transaction volumes and increase productivity.

   We cannot be certain that our business model will be successful or that we
can achieve or sustain revenue growth or generate any profits. The success of
this business model will require, among other things, that we develop and
market solutions with broad market acceptance by our customers, suppliers,
users and strategic partners. We cannot be certain that business-to-business
commerce on the Internet generally, or our purchasing solution, services and
brand in particular, will achieve broad market acceptance. For example,
purchasers may continue purchasing products through their existing methods and
may not adopt an Internet-based purchasing solution because of their comfort
with existing purchasing habits and direct supplier relationships, the costs
and resources required to switch purchasing methods, the need for products not
offered through the Chemdex and Promedix marketplaces, security and privacy
concerns, general reticence about technology or the Internet or the failure of
the market to develop the necessary infrastructure for Internet-based
communications, such as wide-spread Internet access, high-speed modems, high-
speed communication lines and computer availability.

Our gross margins are low and we will have to increase productivity in our
business to be profitable

   Chemdex's gross margin for the nine months ended September 30, 1999 was
approximately 4.9% and Promedix has had no gross margins to date. The combined
company will be dependent on the price discounts we receive from our suppliers,
and thus we are vulnerable to any decrease in these discount rates. Any
decrease would have a significant negative impact on our financial results. Our
gross margins on sales of life sciences research products are small relative to
the margins earned by traditional distributors of life sciences research
products. If we do not increase these discounts, substantially increase our
revenues, and scale our business in a manner that generates increased
productivity, including further automation of our purchasing solution, we may
never achieve profitability. Distributors, in general, operate with low
margins. This is especially true in the life sciences research products and
specialty healthcare products markets.

   In addition, due to our low gross margins, unexpected costs or expenses we
incur would substantially affect our ability to achieve or maintain operating
profits. For example, we generally bear the risks of the loss of products upon
shipment by our suppliers to our customers, of product returns and refunds to
our customers, and of non-collection of accounts receivable. Although we
maintain insurance for claims for damages to our customers or others caused by
our products we do not have insurance coverage for product returns or
uncollectable accounts receivable or have adequate insurance coverage for the
costs of products lost during shipment.

We are subject to government regulation that exposes us to potential liability
and negative publicity

   We currently rely upon our suppliers to meet all packaging, distribution,
labeling, hazard and health information notices to purchasers, record keeping
and licensing requirements applicable to our business during the entire
transaction. Our reliance on suppliers' regulatory due diligence assessment of
purchasers and the compliance by suppliers and purchasers with applicable
governmental regulations may not be sufficient if we are held to need our own
licenses. For example, if we are held to be seller or a distributor of
regulated products

                                       16
<PAGE>

because we did take legal title, we may have inadvertently violated some
governmental regulations by not having the appropriate license or permit and
may be subject to potentially severe civil or criminal penalties and fines for
each offense. We are aware that some of our prior sales may have been made in
the absence of our having the requisite local, state, or federal license or
permit. We may be subject to potentially severe civil and criminal penalties
and fines for each of these sales, which could have a material adverse impact
on our business, revenues, results of operations and financial condition. In
addition to these prior sales, we are unable to verify that our suppliers have
in the past complied, or will in the future comply, with the applicable
governmental regulatory requirements, or that their actions are adequate or
sufficient to satisfy all governmental or other legal requirements that may be
applicable to our sales. We could be fined or exposed to civil or criminal
liability, including monetary fines and injunctions, and we could receive
potential negative publicity, if the applicable governmental regulatory
requirements have not been, or are not being, fully met by our suppliers or by
us directly. Negative publicity, fines and liabilities could also occur if an
unqualified person, or even a qualified customer, lacks the appropriate license
or permits to sell, use or ship, or improperly receives a dangerous or
unlicensed product through the Chemdex or Promedix marketplace. We do not
maintain any reserve for potential liabilities resulting from government
regulation. It is also possible that a number of laws and regulations may be
adopted or interpreted in the United States and abroad with particular
applicability to the Internet.

We rely on a limited number of enterprise customers, and any loss of an
enterprise customer could have a negative effect on us

   We expect that for the foreseeable future we will generate a significant
portion of our revenues from a limited number of enterprise customers. Further,
our enterprise customers are not obligated to use our purchasing solution
exclusively or for any minimum number of transactions or dollar amounts. We
currently do not offer all of the life science research products required by
our customers, and we expect that our customers will continue to use multiple
sources to meet their needs. In addition, our contracts with our customers are
for limited terms and our customers may discontinue use of our Chemdex or
Promedix marketplace at any time upon short notice and without penalty. If we
lose any of our enterprise customers, or if we are unable to add new enterprise
customers, our revenues will not increase as expected, we will lose access to
the users employed by these enterprises, we could lose a number of our product
suppliers, and our brand name and customer and supplier perceptions of our
purchasing solution would be harmed.

We will be very dependent on our strategic relationship with VWR for the
foreseeable future

   We recently entered into a strategic relationship agreement with VWR
Scientific Products Corporation to jointly market VWR laboratory products using
the Chemdex Marketplace. The agreement gives us the right to offer
approximately 350,000 VWR-distributed products to our customers through the
Chemdex Marketplace. VWR and Chemdex are also jointly developing an Internet
purchasing solution for VWR's existing and future customers that will provide
access to three categories of products:

  . products distributed by VWR (VWR core products),

  . products distributed by Chemdex (Chemdex core products), and

  . products that are not distributed by either VWR or Chemdex but are
    purchased from third parties (third- party products).

   The extent to which our operations are integrated with VWR and the potential
financial impact on us of this strategic relationship makes us very dependent
on VWR for the foreseeable future. We may experience technical or logistical
difficulties in integrating VWR's suppliers, products and services with the
Chemdex Marketplace. If we are unable to do so in a timely manner, our
business, revenues, financial condition and results of operations could be
negatively affected. In addition, our agreement with VWR is nonexclusive except
as to the purchase of third-party products by VWR and some other provisions and
has a limited term. We cannot be certain that VWR will not enter into a similar
relationship with one of our competitors, or that VWR will renew our agreement
at the end of its term.

                                       17
<PAGE>

   We receive no fee for orders for VWR core products through the Chemdex
Marketplace from VWR's 40 largest customers and we receive a minimal fee for
all other orders for VWR core products forwarded to VWR. Under the terms of the
agreement, VWR provides some support services for purchasing third-party
products in exchange for a fee which approximates VWR's costs incurred.

   Since we receive minimal gross margins for sales of third-party products,
our gross profit margins on these sales are lower than our margins on sales of
Chemdex core products. To the extent sales of VWR core products or third-party
products increase relative to, or displace our sales of Chemdex core products,
our revenues and gross margins will likely decline, which would make it more
difficult for us to achieve profitability.

Our strategic relationship with VWR may lead to conflicts that could be
detrimental to us

   Our strategic relationship with VWR may lead to conflicts that could be
detrimental to us. For example, we plan to provide the greatest number and
variety of products from the greatest number of suppliers possible; however,
our strategic relationship with VWR may deter other suppliers, particularly
those that compete directly with VWR products, from entering into agreements
with us. In addition, as noted above, our agreement with VWR is nonexclusive,
and it is possible that VWR could enter into similar relationships with one or
more of our competitors, or develop its own purchasing solution that would
compete with ours.

The former Chief Executive Officer of VWR is a member of our Board of
Directors, which may lead to conflicts of interest that could be detrimental to
us

   Jerrold Harris, the former Chief Executive Officer of VWR, is a member of
our Board of Directors. This may lead to conflicts of interest, as VWR is one
of the laboratory supply industry's largest distributors and is a potential
competitor of ours. In addition, VWR has entered into and may in the future
enter into relationships with our competitors, other suppliers or our
customers. Although we intend to have Mr. Harris excuse himself from Board
discussions that involve potential conflicts of interest, we cannot be sure
that this will minimize these conflicts of interests or that Mr. Harris'
position as a member of our Board of Directors will not operate to our
detriment.

The time it takes to sell and implement our solution is long, which could
negatively affect our revenue growth, if any, and make it difficult to predict
our revenues and results of operations

   A key element of our strategy is to market our solution directly to life
sciences and specialty medical products organizations, hospitals and surgery
centers, and to succeed we must satisfy the enterprise purchasing departments,
the information technology groups and the individual users of our Internet-
based purchasing solution. The time it takes to sell and implement our solution
is long and we devote significant sales, marketing and management resources to
the sales process without any assurance that the customer will use the Chemdex
or Promedix marketplace. We are generally required to provide a significant
level of education to our customers and potential customers regarding the use
and benefits of our Internet-based purchasing solution. Furthermore, potential
enterprise customers and a number of their departments typically engage in
extensive internal reviews and analyses before making purchase decisions. The
sale and implementation of our solution are subject to delays due to our
customers' internal budgeting and procedures for approving capital expenditures
and deploying new technologies within their networks. These delays also could
impair our ability to generate revenue.

Even if enterprise customers adopt our purchasing solution, we may not increase
our revenues if users within these enterprises do not use the Chemdex and
Promedix marketplaces

   The combined company's revenues will be primarily derived from purchases of
life sciences research products by researchers, research assistants and other
users within our enterprise customers and by purchases of specialty healthcare
products as directed by healthcare purchasing professionals. These persons may
or may not use the Chemdex and Promedix marketplaces to purchase their research
products and specialty healthcare

                                       18
<PAGE>

products. Even if we successfully maintain existing enterprise customers and
add new enterprise customers, we may not be able to increase revenues if users
within our enterprise customers do not adopt and use the Chemdex and Promedix
marketplaces. Once an enterprise customer adopts our Internet-based purchasing
solution, it takes time for researchers and other users within the enterprise
to become aware of, learn to use and begin using our Chemdex and Promedix
marketplaces. The long sales cycle and the time it takes for researchers and
purchasing professionals to begin using our Internet-based purchasing solution
could negatively affect our revenue growth, if any, and makes it difficult to
predict our results of operations. Also, our efforts to attract users to adopt
and to increase their use of our solution may not be successful, which would
limit our ability to generate revenues from these customers.

Reductions in the research and development budgets and government research
funding of our customers will negatively affect our revenues

   The Chemdex purchasing solution is used by researchers and their assistants
and staff at pharmaceutical and biotechnology companies, and academic and
research institutions. Changes in the research and development budgets of these
companies and institutions and the timing of spending under these budgets can
have a significant effect on the demand for life sciences research products.
These budgets are based on a wide variety of factors including the resources
available to make these expenditures, the spending priorities among various
types of research, and the policies regarding these expenditures during
recessionary periods. Any decrease in life sciences research and development
expenditures by these companies and institutions could have a negative effect
on our revenues.

   A significant portion of our sales are expected to be to research scientists
and entities whose funding is dependent on grants from government agencies such
as the U.S. National Institutes of Health (NIH) and similar domestic and
international agencies. The funding associated with approved NIH grants
generally becomes available at particular times of the year, as determined by
the federal government, and may result in fluctuations in our revenues and
results of operations. Although NIH research funding has increased during the
past several years, grants have, in the past, been frozen for extended periods
or have otherwise become unavailable to various institutions, sometimes without
advance notice. Furthermore, recent government proposals designed to reduce or
eliminate budgetary deficits have included reduced allocations to the NIH and
other government agencies that fund research and development activities. If
government funding, especially NIH grants, were to become unavailable to
researchers for any extended period of time, or if overall research funding
were to decrease, there could be a negative effect on our business, revenues,
results of operations and financial condition.

If we cannot build a critical mass of suppliers and customers, we will not be
able to increase our product offering and draw more customers

   Our business model depends in large part on our ability to build a critical
mass of products and suppliers. To attract and maintain suppliers, we must
build a critical mass of customers. However, customers must perceive value in
our purchasing solution which, in part, depends upon the breadth of our product
offerings from our suppliers. If we are unable to increase the number of
suppliers and draw more customers to the Chemdex and Promedix marketplaces, we
will not be able to benefit from any network effect, where the value to each
participant in the Chemdex and Promedix marketplaces increases with the
addition of each new participant. As a result, the overall value of the Chemdex
and Promedix marketplaces and our purchasing solutions would be harmed, which
would negatively affect our business, revenues, financial condition and results
of operations.

   The ability of Promedix to increase the number of suppliers and products
offered on its marketplace might be limited by several factors, including:
reluctance of suppliers to offer medical products in an online marketplace that
potentially includes their competitors; exclusive or preferential arrangements
signed by suppliers with our competitors; perceptions by suppliers that
preferred treatment is given to other suppliers; and consolidation among
suppliers.

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<PAGE>

The success of our business depends on maintaining and expanding our supplier
base

   Our future success depends in large part upon our ability to offer and
deliver a broad and deep product offering to our customers. We rely on
independent suppliers and manufacturers for products offered through our
Chemdex and Promedix marketplaces. To increase the breadth of our product
offering, including related products that we do not currently offer such as
laboratory equipment and supplies, we must establish relationships with
additional suppliers. Some potential suppliers may view us as detrimental to
their business, since suppliers compete with one another and with us for sales
and customers. Our agreements with suppliers are typically for one-year terms
and we cannot assure you that these agreements will be renewed beyond the
initial term. In addition, these suppliers are not required to accept purchase
orders from us. If we fail to secure products from our suppliers or if a
significant number of suppliers do not renew their agreements with us, the
breadth and depth of products that we can offer users would be decreased. In
addition, there are significant costs, difficulties and risks associated with
adding new products in related markets, such as the difficulty of signing up
new suppliers, obtaining necessary permits, complying with governmental
regulation, pressures on margins, new competition and integration of these new
products into the Chemdex and Promedix marketplaces. These events could result
in decreased adoption and use of our purchasing solution and decreased
revenues, which could have a negative effect on our business, results of
operations and financial condition.

   Our cost of revenues includes cost of goods payable to suppliers. We cannot
assure you that our suppliers will enter into or renew agreements with us on
the same or similar terms as those currently in effect or that the cost of
goods payable to our suppliers will remain the same. Less favorable terms will
make it difficult for us to achieve profitable operations. Any decreases in our
already low gross margins will have a significant negative effect on our
results of operations and financial condition.

   Our supplier agreements are nonexclusive and many of our suppliers sell
their products directly to our customers. In addition, the growing reach and
use of the Internet has further intensified competition in this industry. Some
suppliers provide customers with direct access to products, and if suppliers,
including our current suppliers, provide products to enterprise customers and
their users at a cost lower than ours, our revenues, results of operations and
financial condition could be negatively affected.

If we cannot timely and accurately add supplier product data to our purchasing
solution database we may lose sales and customers, which would adversely affect
our revenues

   Currently, we are responsible for loading supplier product information into
our database and categorizing the information for search purposes. This process
entails a number of risks, including dependence on our suppliers to provide us
in a timely manner with accurate, complete and current information about their
products, and to promptly update this information when it changes. We will not
derive revenue from these products until these data are loaded in our system.
The time period in which we estimate loading these supplier product data is a
forward-looking statement that is subject to risks and uncertainties and actual
results may differ materially from those described in these forward-looking
statements. Timely loading of these products in our database depends upon a
number of factors, including the file formats of the data provided to us by
suppliers and our ability to further automate and expand our operations to
accurately load these data in our product database, any of which could delay
the actual loading of these products beyond the dates estimated by us. Promedix
may in the future use an independent company to input data provided by
suppliers. If this company fails to accurately input the data accurately,
Promedix's reputation might suffer and Promedix might lose customers.

   In addition, we are generally obligated under our supplier agreements to
load updated product data onto our database for access through the Chemdex and
Promedix marketplaces within a specified period of time following their
delivery from the supplier. Our current supplier data backlog could make it
difficult for us to meet these data update obligations to our suppliers. While
we intend to further automate the loading and updating of supplier data on our
system, we cannot assure you that we will be able to do so in a timely manner,
in part because achieving the highest level of this automation is dependent
upon our suppliers' automating their

                                       20
<PAGE>

delivery of product data to us. If our suppliers do not provide us in a timely
manner with accurate, complete and current information about the products we
offer, our database may be less useful to our customers and users and may
expose us to liability. Although we screen our suppliers' information before we
make it available to our customers and users, we cannot guarantee that the
product information available in our Chemdex and Promedix marketplaces will
always be accurate, complete and current, or comply with governmental
regulations. This could expose us to liability or result in decreased adoption
and use of our Internet-based purchasing solution, which could reduce our
revenues and therefore have a negative effect on our results of operations and
financial condition.

If our suppliers do not provide timely and professional delivery of products to
our customers, our business will be harmed

   We also rely on our suppliers and manufacturers to deliver life sciences
research products to our customers in a professional, safe and timely manner.
If our suppliers do not deliver the products to our customers in a
professional, safe and timely manner, then our service will not meet customer
expectations and our reputation and brand will be damaged. In addition,
deliveries that are nonconforming, late or are not accompanied by information
required by applicable law or regulations, could expose us to liability or
result in decreased adoption and use of our Internet-based purchasing solution,
which could have a negative effect on our business, results of operations and
financial condition. Further we, and not our suppliers, typically bear the
responsibility for product refunds and returns and the risk of non-
collectibility of accounts receivable from our customers.

   In conjunction with the spin-off of Promedix's subsidiary Pro Med Co., Inc.,
Promedix plans to enter into an agreement whereby Pro Med Co., Inc. would
fulfill orders placed through the Promedix marketplace that require a
distribution relationship.

To attract customers and suppliers to our Chemdex and Promedix marketplaces, we
must not favor one supplier over another

   The life sciences research products market consists of a complex set of
relationships among manufacturers, suppliers, distributors and customers.
Adoption of our solution by suppliers and customers is dependent on their
perception that we provide a neutral, unbiased marketplace to purchase and sell
life sciences research products. To the extent that we are perceived by our
customers or suppliers as favoring one supplier over another, customers and
suppliers may lose confidence in the Chemdex or Promedix marketplace as fair
and neutral marketplaces and choose alternative solutions. Our relationship
with VWR, including the fact that VWR is a stockholder and is represented on
our Board of Directors, may compromise the perception that we provide a neutral
and unbiased marketplace for life sciences research products. Any bias, whether
perceived or actual, could have a negative impact on our ability to maintain or
increase our supplier base, which in turn may limit our ability to maintain or
increase our customer base. This would reduce revenues and therefore have a
negative impact on our business, results of operations and financial condition.

   Promedix is currently in the process of developing relationships with its
manufactures, suppliers, distributors and customers. It is possible that
customers or suppliers may perceive favoritism toward a particular supplier or
customer. For example, privately negotiated terms between a particular supplier
and customer may result in private terms not available on the open market
place.

We face intense competition that could limit our ability to expand our base of
customers and users

   The market for business-to-business e-commerce and Internet ordering and
purchasing is new and rapidly evolving, and competition is intense and is
expected to increase significantly in the future. We face competition from four
main areas: other companies with e-commerce offerings, traditional suppliers
and distributors of life sciences research products, life sciences companies
that have developed their own purchasing solutions and enterprise software
companies that offer, or may develop, alternative purchasing solutions. We may
not be able to compete successfully against our current or future competitors
and competition could have a material adverse effect on our business, results
of operations and financial condition. Our competitors and potential
competitors

                                       21
<PAGE>

may develop superior Internet purchasing solutions that achieve greater market
acceptance than our solution. In addition, substantially all of our prospective
customers have established long-standing relationships with some of our
competitors or potential competitors, including most of our suppliers.
Accordingly, we cannot be certain that we will be able to expand our customer
list and user base, or retain our current customers or suppliers.

   The online market for specialty medical products, supplies and equipment is
new, rapidly evolving and intensely competitive. Our primary competition
includes e-commerce providers that are developing or have already established
online marketplaces. Many companies that have created websites to serve the
information needs of healthcare professionals are introducing e-commerce
functions that may compete with our services. In addition, providers of online
marketplaces and online auction services that currently focus on other
industries could expand the scope of their services to include specialty
medical products. Existing suppliers of specialty medical products may also
establish online marketplaces that offer services to suppliers and purchasers,
either on their own or by partnering with other companies. Moreover, live
auction houses focusing on specialty medical products may establish online
auction services.

   Competition is likely to intensify as our market matures. As competitive
conditions intensify, competitors may:

  . enter into strategic or commercial relationships with larger, more
    established healthcare specialty medical products and Internet companies;

  . secure services and products from suppliers on more favorable terms;

  . devote greater resources to marketing and promotional campaigns;

  . secure exclusive or preferential arrangements with purchasers or
    suppliers that limit sales through our marketplace; and

  . devote substantially more resources to web site and systems development.

   Many of our existing and potential competitors have longer operating
histories in the specialty medical products market, greater name recognition,
larger customer bases and greater financial, technical and marketing resources
than we do. As a result of these factors, our competitors and potential
competitors may be able to respond more quickly to market forces, undertake
more extensive marketing campaigns for their brands and services and make more
attractive offers to purchasers and suppliers, potential employees and
strategic partners. In addition, new technologies may increase competitive
pressures. We cannot be certain that we will be able to maintain or expand our
user base. We may not be able to compete successfully against current and
future competitors and competition could result in price reductions, reduced
sales, gross margins and operating margins and loss of market share.

Our solution and services are new and face rapid technological changes and if
we do not respond appropriately, we may lose customers

   The market for our solution is characterized by rapid technological
advances, evolving standards in the Internet and software markets, changes in
customer requirements and frequent new product and service introductions and
enhancements. As a result, our future success depends upon our ability to
enhance our current Internet-based purchasing solution and services, to develop
and introduce new solutions and services that will achieve market acceptance,
and where necessary to integrate our Internet-based purchasing solution with
our customers' enterprise resource planning systems. If we do not adequately
respond to the need to develop and introduce new solutions or services, or to
integrate with our customers' enterprise resource planning systems, then our
business, revenues, results of operations and financial condition will be
negatively affected. For example, we may lose market share and ultimately
revenue as our customers switch to our competitors' offerings if:

  . we are unable to develop technology that is a success in the marketplace;

  . our technology does not integrate with our customers' and suppliers'
    systems; and

  . our technology is surpassed by the superior technology of a competitor.

                                       22
<PAGE>

   Further, we may incur significant expense to integrate our purchasing
solution with our customers' enterprise resource planning systems and business
rules, and to maintain this integration as our customers' enterprise resource
planning systems evolve. Failure to provide this integration may delay or
altogether dissuade the market or a particular customer from adopting our
Internet-based purchasing solution, which could negatively affect our revenues
and therefore have a material adverse effect on our business, results of
operations and financial condition.

We lack brand recognition and must devote significant resources toward
attracting users

   Recognition and positive perception of our brand names in the life sciences
and specialty medical products industries are important to our success. We
intend to significantly expand our advertising and publicity efforts in the
near future. However, we may not achieve our desired goal of increasing the
awareness of our brand names. Even if recognition of our name increases, it may
not lead to an increase in the number of visitors to our online marketplace or
increase the number of users of our services.

If we do not successfully develop and timely introduce new versions of our
purchasing solution in the next several months our business will be harmed

   We are currently in the process of developing and integrating new technology
into our Internet-based purchasing solution as part of our planned release of
several enhanced versions of the Chemdex Marketplace over the next few months.
These new releases are planned to include significant enhancements to the user
interfaces, database management and search technology, and security controls,
and will allow us to offer VWR's products to our customers. The planned timing
of introduction of new releases of our purchasing solution is a forward-looking
statement that is subject to risks and uncertainties, and actual timing may
differ materially from that set forth in these forward-looking statements as a
result of a number of factors. Enhancing and introducing new technology into
our purchasing solution involves numerous technical challenges and substantial
personnel resources, and often takes many months to complete. We cannot be
certain that we will be successful at enhancing or integrating this technology
into our Internet-based purchasing solution on a timely basis, or in accordance
with our milestones or our product release objectives. In addition, we cannot
be certain that, once integrated, this technology or our Internet-based
purchasing solution will function as expected. If we are unable to enhance and
integrate this new technology into our purchasing solution on a timely basis,
we may lose customers or experience difficulty obtaining new customers, which
could adversely affect our business, revenues, financial condition and results
of operations. Major enhancements and new solutions and services often require
long development and testing periods. In addition, our Internet-based
purchasing solution is complex and, despite vigorous testing and quality
control procedures, may contain undetected errors or "bugs" when first
introduced or updated. Any inability to timely deliver a quality solution and
services could have a negative effect on our business, revenues, financial
condition and results of operations.

We may not be able to determine or design the features and functionality that
our enterprise customers and users require or prefer

   Our success depends upon our ability to accurately determine the features
and functionality that our enterprise and research customers require or prefer
in an e-commerce solution, and our ability to successfully design and implement
purchasing solutions that include these features and functionality. If we are
unable to determine or design in the features and functionality that enterprise
and research customers require or prefer in an e-commerce solution, our
business will be negatively affected. We have designed the Chemdex and Promedix
marketplaces based upon internal development efforts and feedback from a
relatively limited number of enterprise and users. We cannot be certain,
however, that the features and functionality that we currently offer in the
Chemdex and Promedix marketplaces, or those that we may offer in future
releases of our solution, will satisfy the requirements or preferences of our
current or potential enterprise and research customers.

                                       23
<PAGE>

We will need to manage our expanding business effectively in order to meet
customer and investor expectations

   We have rapidly and significantly expanded our operations and expect to
continue to do so. This growth has placed, and is expected to continue to
place, a significant demand on our sales, marketing, managerial, operational,
financial and other resources. If we cannot manage our growth effectively, it
is likely that our revenues and results of operations will not meet customer
and investor expectations. As of September 30, 1999, we had grown to 175
employees. We expect to hire a significant number of new employees to support
our business.

   Our current information systems, procedures and controls may not continue to
support our operations and may hinder our ability to exploit the market for
selling products to the life sciences and specialty medical products
industries. We are in the process of implementing a new enterprise resource
planning system that will replace our existing accounting and management
information systems and allow for future scalability and enhancements. In
addition, we anticipate requiring additional space to accommodate our growth in
the next six months. We could experience interruptions to our business when we
transition to the new enterprise resource planning system and when we relocate
to new facilities. Even after we implement our new system and relocate to new
facilities, our personnel, systems, procedures, controls and facilities may be
inadequate to support our future operations.

We depend on our key personnel to manage our business effectively in a rapidly
changing market

   Our performance is substantially dependent on the performance of our
executive officers and other key employees. We do not have any employment
agreements with our executive officers and key employees, although some of them
have severance arrangements. Our failure to successfully manage our personnel
requirements would have a negative effect on our business, revenues, financial
condition and results of operations. We have experienced difficulty from time
to time in hiring the personnel necessary to support the growth of our
business, and we may experience similar difficulty in hiring and retaining
personnel in the future. Seven of our eleven executive officers have only been
employed by us since January 1999 or later. Competition for senior management,
experienced sales and marketing personnel, software developers, qualified
engineers and other employees is intense, and we cannot be certain that we will
be successful in attracting and retaining our personnel. The loss of the
services of any of our executive officers or other key employees could have a
negative effect on our business. In particular, the loss of services of David
Perry, our President and Chief Executive Officer, and Pierre Samec, our Chief
Information Officer, would have a detrimental effect on our business. Mr. Perry
is one of the co-founders and is primarily responsible for our vision and
future direction, and Mr. Samec is responsible for all of our technology
systems and software. Promedix relies on the services of many key employees,
including William C. Klintworth, Thomas Sherry and Jamie Locke.

The unpredictability of our quarterly results may negatively affect the trading
price of our common stock

   Our revenues and results of operations may fluctuate significantly in the
future as a result of a variety of factors, many of which are outside of our
control. As a result, you should not rely on period-to-period comparisons of
revenues and results of operations as an indication of our future performance.
Some of the factors that may affect our revenues and results of operations
include:

  . demand for and market acceptance of our Internet-based purchasing
    solution and services;

  . introduction of new and enhanced purchasing solutions and services by us
    or our competitors;

  . budgeting cycles of customers and users;

  . loss of one or more of our key suppliers, customers or strategic
    relationships;

  . changes in our pricing policy or those of our competitors or suppliers;

                                       24
<PAGE>

  . amount and timing of capital expenditures and other costs relating to the
    expansion of our operations;

  . timing and number of new hires;

  . ability to comply with applicable laws and regulations or obtain
    necessary permits and licenses to sell or ship products to customers;

  . technical difficulties with our web site or Internet-based purchasing
    solution;

  . level of activity and funding in the life sciences industry; and

  . general economic conditions.

   We may from time to time make pricing, service or marketing decisions or
enter into strategic business combinations that could have a negative effect on
our business, revenues, financial condition or results of operations for any
number of quarterly periods. For example, we intend to significantly expand our
development and engineering expenses to improve our Internet-based purchasing
solution. In addition, in order to accelerate the promotion of the Chemdex
brand, we intend to increase our marketing budget significantly. These
increases in expenses may negatively affect our results of operations for a
number of quarterly periods and we cannot assure that these measures will
increase our revenues.

   Due to our relatively short operating history, combined with the short
operating history of Promedix, we have limited meaningful historical financial
data upon which to base our planned operating expenses. Accordingly, our
expense levels are based in part on our expectations as to future revenues from
new customers and are relatively fixed in the short term. We cannot be certain
that we will be able to accurately predict our revenues, particularly in light
of our limited operating history, the intense competition in the life sciences
and specialty medical products industries, and the resulting uncertainty as to
the success of our business model. If we fail to accurately predict revenues in
relation to fixed expense levels and we are unable to adjust our operating
expenses in a timely manner in response to lower-than-expected revenues, our
results of operations and financial condition could be negatively affected.

Our business will suffer if the life sciences or specialty medical products
industries does not accept Internet solutions

   Business-to-business e-commerce is a new and emerging business practice that
remains largely untested in the marketplace. Growth in the demand for our
Internet-based purchasing solution and services depends on the adoption of e-
commerce and Internet solutions by life sciences and specialty medical products
industry participants, which requires the acceptance of a new way of conducting
business and purchasing supplies. Our business could suffer dramatically if e-
commerce and Internet solutions are not accepted or not perceived to be
effective.

   The Internet may not prove to be a viable commercial marketplace for the
life sciences and specialty medical products industries for a number of
reasons, including:

  . inadequate development of the necessary infrastructure for Internet-based
    communications within life sciences and specialty medical products
    organizations;

  . security and confidentiality concerns of customers and suppliers;

  . lack of development of complementary products, such as high-speed modems
    and high-speed communication lines;

  . implementation of competing purchasing solutions;

  . lack of human contact that current, traditional suppliers provide; and

  . governmental regulation.

                                       25
<PAGE>

The accelerated growth and increasing volume of Internet traffic may cause
performance problems that may slow adoption of our Internet-based purchasing
solution and the Chemdex and Promedix Marketplaces

   The growth of Internet traffic to very high volumes of use over a relatively
short period of time has caused frequent periods of decreased Internet
performance, delays and, in some cases, system outages. This decreased
performance is caused by limitations inherent in the technology infrastructure
supporting the Internet and the internal networks of Internet users. If
Internet usage continues to grow rapidly, the infrastructure of the Internet
and its users may be unable to support the demands of growing e-commerce usage,
and the Internet's performance and reliability may decline. If our existing or
potential enterprise and research customers experience frequent outages or
delays on the Internet, the adoption or use of our Internet-based, e-commerce
purchasing solution may grow more slowly than we expect or even decline. Our
ability to increase the speed and reliability of our Internet-based purchasing
solution is limited by and depends upon the reliability of both the Internet
and the internal networks of our existing and potential customers. As a result,
if improvements in the infrastructure supporting both the Internet and the
internal networks of our enterprise customers and their users are not made in a
timely fashion, we may have difficulty obtaining new customers, or maintaining
our existing customers, either of which could reduce our potential revenues and
have a negative impact on our business, results of operations and financial
condition.

Security and disruption problems with the Internet or transacting business over
the Internet may inhibit the growth of our Internet-based purchasing solution

   The secure transmission of confidential information over the Internet is
essential to maintaining customer and supplier confidence in our Chemdex and
Promedix marketplaces. Customers generally are concerned with security and
privacy on the Internet and any publicized security problems could inhibit the
growth of the Internet, and therefore our purchasing solution, as a means of
conducting transactions. Substantial security breaches on our system could
significantly harm our business. A party that is able to circumvent our
security systems could misappropriate proprietary information or cause
interruptions in our operations. We incur substantial expense to protect
against and remedy security breaches and their consequences. Despite the
implementation of security measures, our networks may be vulnerable to
unauthorized and illegal access, computer viruses and other disruptive
problems. Eliminating computer viruses and alleviating other security problems
may require interruptions, delays or cessation of service to users accessing
our solution.

   Internet service providers and on-line service providers have in the past
experienced, and may in the future experience, interruptions in service as a
result of the accidental or intentional actions of Internet users, current and
former employees or others. We may be required to expend significant capital or
other resources to protect against the threat of security breaches or to
alleviate problems caused by these breaches. Although we intend to continue to
implement industry-standard security measures, we cannot be certain that
measures implemented by us will not be circumvented in the future.

   If we experience a security breach that results in the misappropriation of
proprietary information maintained in our systems or if we experience
interruptions in our service, our reputation and brand may be damaged and we
may be exposed to a risk of loss or litigation and possible liability. Damage
to our reputation and brand could cause us to lose suppliers and customers and
negatively affect our business, results of operations and financial condition.
Our insurance policies may not be adequate to reimburse us for losses caused by
security breaches or service disruption.

System failure may cause interruption of our services

   The performance of our server and networking hardware and software
infrastructure is critical to our business and reputation and our ability to
process transactions, provide high quality customer service, and attract and
retain customers, suppliers, users and strategic partners. Currently our
infrastructure and systems are located at one site at Exodus Communications in
Sunnyvale, California. We anticipate adding a mirror site at a

                                       26
<PAGE>

different, distant location. Until then, we depend on our single-site
infrastructure and any disruption to this infrastructure resulting from a
natural disaster or other event could result in an interruption in our service,
fewer transactions and, if sustained or repeated, could impair our reputation
and the attractiveness of our services.

   Our systems and operations are vulnerable to damage or interruption from
human error, natural disasters, power loss, telecommunications failures, break-
ins, sabotage, computer viruses, intentional acts of vandalism and similar
events. We do not have a formal disaster recovery plan or alternative provider
of hosting services. In addition, we do not carry sufficient business
interruption insurance to compensate us for losses that could occur. Any
failure on our part to expand our system or Internet infrastructure to keep up
with the demands of our customers and users, or any system failure that causes
an interruption in service or a decrease in responsiveness of our Internet-
based purchasing solution or web site, could result in fewer transactions and,
if sustained or repeated, could impair our reputation and the attractiveness of
our brand name, which would adversely affect our business, revenues, financial
condition and results of operations.

We face year 2000 risks associated with our own systems and those of our
customers, suppliers and the Internet

   Significant uncertainty exists concerning the potential costs and effects
associated with any year 2000 compliance problems. Any year 2000 compliance
problems faced by us, our customers, suppliers and strategic partners could
have a negative effect on our business, revenues, and results of operations and
financial condition. In addition, our ability to operate is dependent upon
delivery of accurate, electronic information via the Internet. To the extent
year 2000 issues result in the long-term inoperability of the Internet, the
Chemdex or Promedix marketplace, or the systems of our suppliers, our business,
revenues, financial condition and results of operations could be seriously
harmed.

   Although we believe that our internally developed applications and systems
are designed to be year 2000 compliant, we use third-party equipment and
software that may not be year 2000 compliant. In addition, until some of the
billing and cash collection functions for spot buying services are transitioned
to Chemdex, we are dependent upon VWR's systems for receiving payment for
products purchased using the spot buying services. Failure of our applications
and services, VWR's billing and collection system, or third-party equipment and
software that we use, to be year 2000 compliant could result in the Chemdex and
Promedix marketplaces not being used for purchasing products, the termination
of our customer agreements or in liability for damages, any of which could have
a material adverse effect on our business, results of operations and financial
condition. Many of our customers' systems with which the Chemdex and Promedix
marketplaces integrate may not yet be year 2000 compliant. In addition, our
suppliers' systems may not be year 2000 compliant. Any negative effects on our
customers' or suppliers' systems as a result of the year 2000 problem, or
unknown, non-compliance of our own systems, could have a negative effect on our
business, results of operations and financial condition and we do not have a
formal contingency plan to address year 2000 issues. See "Management's
Discussion and Analysis of Financial Condition and Results of Operations--Year
2000 Compliance."

We may require additional capital for our operations

   We currently anticipate that our existing borrowing arrangements and
available funds will be sufficient to meet our anticipated needs for working
capital and capital expenditures for at least the next 12 months. This is a
forward-looking statement that is subject to risks and uncertainties and actual
results may differ materially from those described in this forward-looking
statement. We may need to raise additional funds in the future in order to fund
rapid expansion, to pursue customer sales and implementation, to develop new or
enhanced solutions and services, to respond to competitive pressures or to
acquire complementary businesses, technologies or services.

   If we raise additional funds through the issuance of equity or convertible
debt securities, the percentage ownership of our stockholders will be reduced,
stockholders may experience additional dilution and these

                                       27
<PAGE>

securities may have powers, preferences and rights that are senior to those of
the rights of our common stock. We cannot be certain that additional financing
will be available on terms favorable to us, if at all. If adequate funds are
not available or not available on acceptable terms, we may be unable to fund
our expansion, promote our brand identity, take advantage of unanticipated
acquisition opportunities, develop or enhance services or respond to
competitive pressures. Any inability to do so could have a negative effect on
our business, revenues, financial condition and results of operations.

Future acquisitions could dilute our stockholders and could result in adverse
accounting consequences

   The combined company intends to pay for some of its acquisitions by issuing
additional common stock and this would dilute its stockholders. The combined
company may also use cash to buy companies or technologies, and it may need to
incur debt to pay for these acquisitions. Acquisition financing may not be
available on favorable terms or at all. In addition, the combined company may
be required to amortize significant amounts of goodwill and other intangible
assets in connection with future acquisitions, which would materially increase
its operating expenses.

Future sales of shares could affect the stock price

   The market price of Chemdex common stock could fall dramatically if
stockholders sell large amounts of stock in the public market following the
merger. These sales, or the possibility that these sales may occur, could make
the combined company's stockholders unable to realize the value of the merger
consideration received, as measured prior to completion of the merger, and may
make it more difficult for Chemdex to sell equity or equity-related securities
in the future. Before the merger, a significant portion of the common stock of
Chemdex was subject to restrictions on transfer under federal securities law
and "lock-up" agreements with the underwriters of our initial public offering,
and there was no public market for the capital stock of Promedix. After the
merger,     of the outstanding     shares of Chemdex will be eligible for
immediate sale. However, shares held by affiliates of Chemdex will be subject
to limitations on the volume of sales under federal securities laws. Some
Chemdex stockholders will also have the right to demand registration of their
shares for resale.

Our planned international expansion may make it more difficult to manage our
business

   We expect to enter the international market. To do so, we plan to establish
international operations, hire additional personnel and establish relationships
with additional suppliers and partners. This expansion will require significant
management attention and financial resources and could have a negative effect
on our business, revenues, financial condition and results of operations. We
cannot assure you that we will be able to create or sustain international
demand for our Internet-based purchasing solution and services. In addition,
our international business may be subject to a variety of risks, including
applicable government regulation, difficulties in collecting international
accounts receivable, longer payment cycles, increased costs associated with
maintaining international marketing efforts, the introduction of non-tariff
barriers and higher duty rates and difficulties in enforcement of contractual
obligations and intellectual property rights. We cannot assure you that these
factors will not have a negative effect on any future international sales and,
consequently, on our business, results of operations and financial condition.

We may be exposed to product liability claims

   We face potential liability for claims based on the type and adequacy of the
information and data that we obtain from suppliers and make available, and the
nature of the products that we sell and distribute utilizing the Internet,
including claims for breach of warranty, product liability, misrepresentation,
violation of governmental regulations and other commercial claims. In
particular, we bear the risk of liability for product loss, spill, or release,
and resulting damages to persons and property during delivery by the supplier
to the customer and return by the customer to the supplier. We do not pass
through the manufacturers' warranties on the products we distribute. However,
we bear the risk of loss of revenue from the product sale if a purchaser does
not pay

                                       28
<PAGE>

for a defective product. We also bear some risk if our suppliers have not
obtained appropriate approvals for products regulated by the U. S. Food & Drug
Administration, or do not comply with the requirements relating to those
approvals. The failure to obtain or comply with those approvals, or other
failures by these products themselves, could result in costly product recalls,
significant fines and judgments, civil and criminal liabilities, and negative
publicity. Although we maintain general liability insurance, our insurance may
not cover some claims, penalties, or spills, is subject to policy limits and
exclusions, and may not be adequate to fully indemnify us or our employees for
any civil, governmental or criminal liability that may be imposed. Furthermore,
this insurance may not be available at commercially reasonable rates in the
future. Any liability not covered by our insurance or in excess of our
insurance coverage could have a negative effect on our business, results of
operations and financial condition. Our liability is potentially greater with
respect to sales to users and others that are not affiliated with an enterprise
customer.

   Because we facilitate the sale of many different life sciences and special
medical products by suppliers, we may become subject to legal proceedings
regarding defects in these products. Note, however, that we take title of
certain products between the period of time after the supplier has delivered
the product but before the product has been accepted by the customer. Any
claims, with or without merit, could be time-consuming to defend, result in
costly litigation or divert management's attention and resources.

   We also seek to obtain indemnification from our suppliers against some of
these claims. However, the scope of the indemnification is limited, a few of
our suppliers have not agreed to indemnify us, and some suppliers may be unable
or unwilling to indemnify us in the future. In addition, we are not in a
position to monitor our suppliers' activities. Therefore, we are exposed to
liability and risk for these claims.

We depend on our intellectual property rights and are subject to the risk of
infringement or loss of rights

   Our intellectual property is important to our business, and we seek to
protect our intellectual property through copyrights, trademarks, trade
secrets, confidentiality provisions in our customer, supplier and strategic
relationship agreements, nondisclosure agreements with third parties, and
invention assignment agreements with our employees and contractors. We cannot
assure that measures we take to protect our intellectual property will be
successful or that third parties will not develop alternative purchasing
solutions that do not infringe upon our intellectual property. In addition, we
could be subject to intellectual property infringement claims by others. Our
failure to protect against misappropriation of our intellectual property, or
claims that we are infringing the intellectual property of third parties could
have a negative effect on our business, revenues, financial condition and
results of operations.

   The only federally registered intellectual property Promedix owns is the
trademark "Promedix." Promedix will license its software to customers which may
complicate Promedix's ability to protect its intellectual property rights.

   Promedix currently licenses the software for the Promedix web site from a
third party developer. The use of this software is an integral part of
Promedix's internet solution, and therefore Promedix relies heavily on this
third party developer. The current relationship between Promedix and this third
party developer is strained. An ongoing deterioration of the relationship could
limit Promedix's access to source code needed to operate the web site, leaving
the functionality of the Internet site significantly impaired.

Regulation or taxation of the Internet or transacting business over the
Internet may inhibit the growth of our Internet-based purchasing solution

   Due to the increasing popularity and use of the Internet and of e-commerce,
it is possible that a number of taxes, laws and regulations may be adopted in
the U.S. and abroad with particular applicability to the Internet and e-
commerce transactions. It is possible that governments will adopt taxes and
enact legislation that may be applicable to us in areas such as content,
product distribution, network security, encryption and the use of key

                                       29
<PAGE>

escrow, data and privacy protection, electronic authentication or "digital"
signatures, illegal and harmful content, access charges and re-transmission
activities. Moreover, the applicability to the Internet of existing laws
governing issues such as property ownership, content, taxation, defamation and
personal privacy is uncertain. Taxes, laws or regulations may limit the growth
of the Internet, dampen e-commerce and reduce the number of transactions,
increase our cost of doing business or increase our legal exposure. Any of
these factors could have a negative effect on our business, revenues, and
results of operations and financial condition.

Officers and directors of Chemdex and Promedix may have different interests
from yours

   The directors and officers of Chemdex and Promedix may have interests in the
mergers and may participate in arrangements that are different from, or are in
addition to, those of Chemdex and Promedix stockholders generally. For further
information regarding these interests, see the section entitled "Interests of
Certain Persons in the Merger" on page  .

You will not know the exchange ratio for the Chemdex common stock to be issued
to Promedix stockholders until after the stockholder meetings

   The number of shares received by securityholders of Promedix depends upon
how many shares of Promedix stock are outstanding and are issuable upon
exercise of options and warrants outstanding at the time of the closing of the
merger. As such, you will not know the exchange ratio for the Chemdex common
stock to be issued to Promedix stockholders until after the stockholder
meetings. Based on the shares of Promedix capital stock outstanding and options
to purchase shares of Promedix capital stock, giving effect to the pro forma
adjustments included in the Unaudited Pro Forma Combined Condensed Financial
Statements (see Note 1 of Notes to on page 72), Chemdex would issue 9,693,958
shares in respect of the Promedix common stock and would assume options for
2,363,408 shares of Chemdex common stock. The exchange ratio would be
approximately 1.2795.

We expect the price of our common stock to be volatile

   The market price of the common stock may fluctuate significantly in response
to a number of factors, some which are beyond our control, including:

  . quarterly variations in our operating results;

  . changes in estimates of our financial performance by securities analysts;

  . changes in market valuation of Internet commerce companies generally;

  . announcements by us of significant contracts, acquisitions, strategic
    partnerships, joint ventures or capital commitments;

  . loss of a major customer, supplier or strategic partner, or failure to
    complete a sale of our purchasing solution to a significant customer;

  . additions or departures of any of our key personnel;

  . future sales of our common stock; and

  . stock market price and volume fluctuations, which are particularly common
    among highly volatile securities of Internet companies.

   In the past, securities class action litigation has often been brought
against a company following periods of volatility in the market price of its
securities. We may in the future be the target of similar litigation.
Securities litigation could result in substantial costs and divert management's
attention and resources, which could have a negative effect on our business,
results of operations and financial condition.

We may be subject to litigation arising out of products sold through our
marketplace

   Because we facilitate the sale of many different life sciences and special
medical products by suppliers, we may become subject to legal proceedings
regarding defects in these products, even though Chemdex does not

                                       30
<PAGE>

take title to these products. Note however that Promedix does take title of
these products between the period of time after the supplier has delivered the
product but before the product has been accepted by the customer. Any claims,
with or without merit, could be time-consuming to defend, result in costly
litigation; or divert management's attention and resources.

Anti-Takeover Provisions

   Anti-takeover provisions may adversely effect the combined company's stock
price and make it more difficult for a third party to acquire the combined
company.

   Provisions of Chemdex's charter documents may have the effect of delaying or
preventing a change in control of the combined company or its management, which
could have a material adverse effect on the market price of the combined
company's common stock. These include provisions:

  . relating to a classified board of directors and provisions eliminating
    cumulative voting;

  . eliminating the ability of stockholders to take actions by written
    consent; and

  . limiting the ability of stockholders to raise matters at a meeting of
    stockholders without giving advance notice.

   In addition, the combined company's board of directors has authority to
issue up to 2,500,000 shares of preferred stock and to fix the rights,
preferences, privileges and restrictions, including voting rights, of these
shares without any further vote or action by the stockholders. The rights of
the holders of Chemdex common stock will be subject to, and may be adversely
affected by, the rights of the holders of any preferred stock that Chemdex may
issue in the future. The issuance of preferred stock, while providing desirable
flexibility in connection with possible acquisitions and other corporate
purposes, could have the effect of making it more difficult for a third party
to acquire a majority of Chemdex's outstanding voting stock, thereby delaying,
deferring or preventing a change in control of Chemdex. Chemdex has no present
plan to issue shares of preferred stock.

                                       31
<PAGE>

                          FORWARD-LOOKING INFORMATION

   Certain statements contained in or incorporated by reference into this
document are "forward looking statements" within the meaning of the United
States Private Securities Litigation Reform Act of 1995. All forward looking
statements involve risks and uncertainties. In particular, any statements
regarding the benefits of the merger, as well as expectations with respect to
future sales, operating efficiencies and product expansion, are subject to
known and unknown risks, uncertainties and contingencies, many of which are
beyond the control of Chemdex and Promedix, which may cause actual results,
performance or achievements to differ materially from anticipated results,
performance or achievements. Factors that might affect such forward looking
statements include, among other things:

  . the ability to integrate Promedix into Chemdex's operations,

  . overall economic and business conditions,

  . the demand for Chemdex's and Promedix's goods and services,

  . competitive factors in the industries in which Chemdex and Promedix
    compete,

  . changes in government regulation,

  . changes in tax requirements, including tax rate changes, new tax laws and
    revised tax law interpretations,

  . interest rate fluctuations, foreign currency rate fluctuations and other
    capital market conditions, economic and political conditions in
    international markets, including governmental changes and restrictions on
    the ability to transfer capital across borders,

  . the ability to achieve anticipated synergies and other cost savings in
    connection with acquisitions,

  . the timing, impact and other uncertainties of future acquisitions by
    Chemdex, and

  . the ability of Chemdex and Promedix, and the ability of their respective
    customers and suppliers, to replace, modify or upgrade computer programs
    in order to adequately address the Year 2000 issue.

                                       32
<PAGE>

                          THE PROMEDIX SPECIAL MEETING

General; Date, Time and Place

   This proxy statement and prospectus is being furnished to holders of
Promedix stock in connection with the solicitation of proxies by the Promedix
board of directors for use at the Promedix special meeting to be held on
 , 1999 at the offices of Promedix, 448 East Winchester Avenue, Suite 2000 Salt
Lake City, Utah 84107 commencing at 10:00 a.m., local time, and at any
adjournment or postponement of the meeting.

   This proxy statement and prospectus and the accompanying forms of proxy are
first being mailed to stockholders of Promedix on or about        , 1999.

Matters to be Considered

   At the Promedix special meeting, Promedix stockholders will be asked to
adopt the merger agreement and approve the merger and to approve such other
matters as may properly be brought before the meeting.

Board of Directors' Recommendation

   The Promedix board has unanimously approved the adoption of the proposals
listed above. In particular, the Promedix board of directors believes that the
terms of the merger agreement are advisable, fair to and in the best interests
of Promedix and its stockholders, and unanimously recommends that holders of
shares of Promedix common stock and preferred stock vote FOR approval and
adoption of the merger agreement and each of the other proposals.

Record Date and Outstanding Shares

   The Promedix board of directors has fixed        , 1999 as the record date
for determining the holders of Promedix stock who are entitled to notice of and
to vote at the special meeting. As of the close of business on the record date,
there were     shares of common stock and      shares of Series A preferred
stock outstanding and entitled to vote. The holders of common stock are
entitled to cast one vote for each share of common stock they hold on each
matter submitted to a vote at the special meeting. The holders of the Series A
preferred stock are entitled to cast one vote for each share of common stock
into which each preferred stock could then be converted on each matter
submitted to a vote at the special meeting. The presence in person or by proxy
of the holders of a majority of the shares of Promedix stock entitled to vote
is necessary to constitute a quorum for the transaction of business at the
special meeting. Under the Delaware corporation statute, the affirmative vote
of at least a majority of the outstanding shares of Promedix stock is required
for the adoption of the merger agreement. In addition, the affirmative vote of
the holders of at least a majority of the outstanding shares of Series A
preferred stock is required for adoption of the merger agreement pursuant to
Promedix's certificate of incorporation. If a stockholder abstains from voting,
that abstention will have the practical effect of voting against the adoption
of the merger agreement.

   As of the record date, 3,105,867 (approximately 33%) of the outstanding
shares of common stock and 3,996,800 (approximately 99%) of the outstanding
shares of Series A preferred stock were beneficially owned by directors and
executive officers of Promedix and their affiliates. Stockholders of Promedix
holding in the aggregate approximately 74.7% of the Promedix common stock and
77.5% of the Promedix preferred stock have agreed to vote all of their shares
in favor of the adoption of the merger agreement and approval of the merger.
Consequently, adoption of the merger agreement and approval of the merger by
the Promedix stockholders is assured.


                                       33
<PAGE>

Solicitation of Proxies; Expenses

   This proxy statement and prospectus is being furnished to Promedix
stockholders in connection with the solicitation of proxies by the Promedix
board of directors for use at the Promedix special meeting, and is accompanied
by a form of proxy.

   All shares of Promedix stock that are entitled to vote and are represented
at the Promedix special meeting by properly executed proxies received prior to
or at the meeting, and not revoked, will be voted at the meeting in accordance
with the instructions indicated on the proxies. If no instructions are so
indicated, the proxies will be voted for approval and adoption of the merger
agreement, except for proxies submitted by record holders of shares of Promedix
stock who indicate that they have not received voting instructions from the
beneficial holders of those shares.

   If any other matters are properly presented for consideration at the
Promedix special meeting, the persons named in the enclosed form of proxy will
have the discretion to vote on those matters using their best judgment.
Additional matters which may come before the meeting include consideration of a
motion to adjourn the meeting to another time and/or place, which may be
necessary for the purpose of soliciting additional proxies from Promedix
stockholders. The proxy holders will not adjourn the meeting if there are
insufficient votes to approve the proposals at the date of the meeting.

   Any person who gives a proxy may revoke it at any time before it is voted.
To revoke a proxy, you must (1) submit a later dated proxy with respect to the
same shares at any time prior to the vote on the adoption of the merger
agreement, (2) deliver written notice of revocation to the Secretary of
Promedix at any time prior to the vote or (3) attend the special meeting and
vote in person. Your attendance at the special meeting alone is not sufficient
to revoke a proxy.

   Promedix will bear all expenses of its solicitation of proxies, including
the cost of mailing this proxy statement and prospectus. In addition to
solicitation by mail, directors, officers and employees of Promedix may solicit
proxies in person or by telephone, fax or other means of communication. These
directors, officers and employees will not receive additional compensation.
However, they may be reimbursed for reasonable out-of-pocket expenses that they
incur in connection with this solicitation.

   PROMEDIX STOCKHOLDERS SHOULD NOT SEND ANY STOCK CERTIFICATES WITH THEIR
PROXY CARDS.

Recommendation of the Board of Directors of Promedix

   THE BOARD OF DIRECTORS OF PROMEDIX HAS UNANIMOUSLY DETERMINED THAT THE
MERGER IS FAIR TO AND IN THE BEST INTERESTS OF PROMEDIX AND ITS STOCKHOLDERS
AND UNANIMOUSLY RECOMMENDS THAT YOU VOTE FOR THE APPROVAL AND ADOPTION OF THE
MERGER AGREEMENT.

                                       34
<PAGE>

                          THE CHEMDEX SPECIAL MEETING

General; Date, Time and Place

   This proxy statement and prospectus is being furnished to holders of Chemdex
stock in connection with the solicitation of proxies by the Chemdex board of
directors for use at the Chemdex special meeting to be held on        , 1999 at
the offices of Chemdex, 1500 Plymouth Street, Mountain View, California,
commencing at 10:00 a.m., local time, and at any adjournment or postponement of
the meeting.

   This proxy statement and prospectus and the accompanying forms of proxy are
first being mailed to stockholders of Promedix on or about  , 1999.

Matters to be Considered

   At the Chemdex special meeting, holders of Chemdex common stock will be
asked to consider and vote on the following proposals:

     1.  approve the issuance of up to a maximum of 12,057,366 shares of
  Chemdex common stock for all shares of outstanding Promedix capital stock,
  in connection with the merger whereby Promedix will become a wholly-owned
  subsidiary of Chemdex and Chemdex will assume Promedix's stock option plan;

     2.  an increase the number of shares available for issuance under the
  Chemdex 1999 Employee Stock Purchase Plan by 300,000 shares to a total of
  1,050,000 shares;

     3. an increase the number of shares of Chemdex common stock available
  for issuance under the Chemdex 1998 Stock Plan by 4,250,000 shares to a
  total of 10,375,000 shares; and

     4. any other matter that may properly come before the meeting.

Board of Directors' Recommendation

   The Chemdex board has approved the adoption of the proposals listed above.
In particular, the Chemdex board of directors believes that the terms of the
issuance of stock in connection with the merger is advisable, fair to and in
the best interests of Chemdex and its stockholders, and recommends that holders
of shares of Chemdex common stock vote FOR approval and adoption of the stock
issuance and each of the other proposals.

Record Date and Outstanding Shares

   The Chemdex board of directors has fixed        , 1999 as the record date
for determining the holders of Chemdex stock who are entitled to notice of and
to vote at the special meeting. As of the close of business on the record date,
there were     shares of common stock outstanding and entitled to vote. The
holders of common stock are entitled to cast one vote for each share of common
stock they hold on each matter submitted to a vote at the special meeting. The
presence in person or by proxy of the holders of a majority of the shares of
Chemdex stock entitled to vote is necessary to constitute a quorum for the
transaction of business at the special meeting.

   As of the record date,     (approximately  %) of the outstanding shares of
common stock were beneficially owned by directors and executive officers of
Chemdex and their affiliates.

Solicitation of Proxies; Expenses

   This proxy statement and prospectus is being furnished to Chemdex
stockholders in connection with the solicitation of proxies by the Chemdex
board of directors for use at the Chemdex special meeting, and is accompanied
by a form of proxy.

                                       35
<PAGE>

   All shares of Chemdex stock that are entitled to vote and are represented at
the Chemdex special meeting by properly executed proxies received prior to or
at the meeting, and not revoked, will be voted at the meeting in accordance
with the instructions indicated on the proxies. If no instructions are so
indicated, the proxies will be voted for approval of the proposals, except for
proxies submitted by record holders of shares of Chemdex stock who indicate
that they have not received voting instructions from the beneficial holders of
those shares.

   If any other matters are properly presented for consideration at the Chemdex
special meeting, the persons named in the enclosed form of proxy will have the
discretion to vote on those matters using their best judgment. Additional
matters which may come before the meeting include consideration of a motion to
adjourn the meeting to another time and/or place, which may be necessary for
the purpose of soliciting additional proxies from Chemdex stockholders. The
proxy holders will not adjourn the meeting if there are insufficient votes to
approve the proposals at the date of the meeting.

   Any person who gives a proxy may revoke it at any time before it is voted.
To revoke a proxy, you must (1) submit a later dated proxy with respect to the
same shares at any time prior to the vote on the adoption of the merger
agreement, (2) deliver written notice of revocation to the Secretary of Chemdex
at any time prior to the vote or (3) attend the special meeting and vote in
person. Your attendance at the special meeting alone is not sufficient to
revoke a proxy.

   Chemdex will bear all expenses of its solicitation of proxies, including the
cost of mailing this proxy statement and prospectus. In addition to
solicitation by mail, directors, officers and employees of Chemdex may solicit
proxies in person or by telephone, fax or other means of communication. These
directors, officers and employees will not receive additional compensation.
However, they may be reimbursed for reasonable out-of-pocket expenses that they
incur in connection with this solicitation.

Board of Directors' Recommendations

   THE CHEMDEX BOARD OF DIRECTORS HAS DETERMINED THAT THE ISSUANCE OF STOCK IN
CONNECTION WITH THE MERGER IS FAIR TO AND IN THE BEST INTERESTS OF CHEMDEX AND
ITS STOCKHOLDERS AND RECOMMENDS THAT YOU VOTE FOR THE STOCK ISSUANCE.

   THE CHEMDEX BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE APPROVAL OF THE
AMENDMENT TO THE 1999 EMPLOYEE STOCK PURCHASE PLAN.

   THE CHEMDEX BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE APPROVAL OF THE
AMENDMENT TO THE 1998 STOCK OPTION PLAN.

                                       36
<PAGE>

                                 Proposal No. 1

                                   THE MERGER

   This section, as well as the section "Other Terms of The Merger Agreement,"
describe the material aspects of the proposed merger. These discussions are
qualified in their entirety by reference to the merger agreement, which is
attached as Annex A to this document, and to the other agreements and documents
that are discussed in this document and that are filed as exhibits to the
registration statement of which this document forms a part. YOU SHOULD READ THE
MERGER AGREEMENT IN ITS ENTIRETY AS IT IS THE LEGAL DOCUMENT THAT GOVERNS THE
MERGER.

Background of the Merger

   Beginning in August 1999, senior executives of Chemdex and Promedix
conducted discussions concerning possible strategic alliances between Chemdex
and Promedix. On various occasions during August 1999, members of each
company's management team met to discuss a possible merger between the two
companies.

   On August 31, 1999, Chemdex formally retained Morgan Stanley to provide
financial advisory services in connection with a possible merger of Promedix by
Chemdex.

   On September 2, 1999, senior executives of Chemdex and representatives of
Morgan Stanley conducted business and financial due diligence on Promedix with
senior executives of Promedix. In addition, David Perry, the Chief Executive
Officer of Chemdex and a representative of Morgan Stanley also met with William
C. Klintworth, the Chief Executive Officer of Promedix and its legal advisors
to negotiate the material terms of a merger between the two companies. At this
meeting, a non-binding term sheet memorializing the material terms of the
merger was agreed to. The terms of the non-binding term sheet were subject to
the satisfactory completion of due diligence and board approval by both
companies.

   On September 3, 1999, representatives of Morgan Stanley and Venture Law
Group negotiated with representatives of Orrick, Herrington & Sutcliffe LLP the
principal terms of an exclusivity agreement, which was executed by the Chief
Executive Officers of both Chemdex and Promedix later that day. Pursuant to the
exclusivity agreement, Promedix agreed not to solicit or enter into a financing
transaction or an alternative sale transaction, and Chemdex agreed not to
solicit or enter into an alternative acquisition transaction for a defined
period of time.

   On September 7, 1999, representatives of Chemdex and Morgan Stanley, in a
series of telephonic meetings, conducted further business and financial due
diligence with Promedix.

   On September 8, 1999, senior executives of Chemdex and representatives of
Morgan Stanley presented an overview of the possible merger of Promedix to the
Chemdex board of directors. Following an extended discussion, the Chemdex board
of directors authorized the Chemdex management team and Morgan Stanley to
continue their discussions regarding a possible transaction with Promedix. On
the same day, Promedix executives described the material terms of the proposed
merger to the Promedix board of directors. The board members and executives
discussed the transaction structure, negotiations, strategic merit and risks of
the proposed merger.

   On September 10, 1999, senior executives of Chemdex held a telephonic
meeting with the Chemdex board of directors to review the status of the merger
discussions between Chemdex and Promedix.

   On September 14, 1999, senior executives of Chemdex and a representative of
Morgan Stanley met with senior executives of Promedix in Salt Lake City to
conduct financial due diligence.

   On the morning of September 21, 1999, the Chemdex board of directors held a
special meeting to discuss the status of the Promedix merger. Senior management
of Chemdex and representatives of Morgan Stanley and Venture Law Group reviewed
the status of negotiations with Promedix, the potential benefits and risks of
the transaction with Promedix and the principal terms of the draft merger
agreement and related documents.

                                       37
<PAGE>

Morgan Stanley reviewed the strategic rationale for, and the financial analyses
relating to, the proposed merger. At the meeting, Morgan Stanley provided its
opinion that the consideration paid pursuant to the merger agreement was fair,
from a financial point of view, to Chemdex. Following the discussion, the
Chemdex board of directors determined that the proposed merger was advisable
and approved the merger agreement and related documents. Also on September 21,
1999, the Promedix board of directors approved the merger by unanimous written
consent.

   In the afternoon of September 21, 1999, senior executives of Chemdex and
Promedix signed and delivered to each other the final merger agreement and
certain ancillary agreements, and on September 22, the companies jointly
announced the transaction.

Reasons of Promedix for the Merger; Recommendation of the Board of Directors of
Promedix

   The Promedix board has based its approval of the merger and its
determination that the merger agreement is in the best interests of Promedix
and its stockholders upon a number of factors, including the following
advantages of the merger:

  . Technological Synergies. The overlap of research and development efforts
    and the potential synergy of Chemdex's technologies with Promedix's
    technologies will enable the combined company to more effectively respond
    to customer needs and compete in the dynamic marketplace and reach the
    marketplace more quickly with a catalog-based purchasing solution;

  . Increased Market Presence and Greater Economies of Scale. The merger will
    create a combined company with significantly greater resources, most
    notably, a larger addressable market for the Chemdex purchasing solution.
    With expanded resources, the combined company should be able to achieve
    greater sales, greater leverage of current and future infrastructure,
    operational efficiencies, and better service of its customers;

  . Strength of Combined Management Team. The merger will potentially create
    a combined company with an experienced management team that has the
    breadth and depth to effectively lead and manage the combined company's
    growth and extend its leadership in the business to business marketplace.
    Promedix believes that the experience of the Chemdex management team will
    provide significant benefits from both an operational and strategic
    standpoint;

  . Premium. The merger provides Promedix stockholders with the opportunity
    to receive a significant premium over the most recent price for shares of
    Promedix capital stock;

  . Future Appreciation. Promedix stockholders will have the ability to
    continue to participate in the growth of the business conducted by
    Chemdex and Promedix after the merger and to benefit from the potential
    appreciation in the value of Chemdex common shares;

  . Increased Visibility as a Public Company. The merger will enable Promedix
    to achieve a measure of visibility as a public company that will enhance
    its position with customers, partners, and employees; and

  . Increased Liquidity. The public float and trading volume of Chemdex
    common stock provide Promedix stockholders the opportunity to gain
    greater liquidity in their investment.

   The Promedix board also considered the following potentially negative
factors:

  . the potential disruption of Promedix's business that might result from
    both employee and customer uncertainty as a result of the announcement of
    the merger;

  . the risk that, despite the intentions and efforts of the parties to
    reassure Promedix's customers and distributors regarding the combined
    company's intention to support their future sales efforts, the
    announcement of the merger could result in customer decisions to delay or
    cancel purchases of Promedix's products;

  . the possibility that the merger might not be completed and customer's
    potentially negative response to the interrupted merger;

                                       38
<PAGE>

  . the effects of the public announcement of the merger on Promedix's
    ability to attract and retain key management, marketing and technical
    personnel; and

  . the other risks described above under "Risk Factors."

   After detailed consideration of these factors, the Promedix board concluded
that the potential benefits of the merger outweighed these considerations and
determined that the merger was fair to and in the best interests of Promedix
and its stockholders.

   The above discussion of the information and factors considered by the
Promedix board is not exhaustive and does not include all factors considered by
the Promedix board. In view of the variety of factors considered in connection
with its evaluation of the merger, the Promedix board did not find it
practicable to, and did not, quantify or otherwise assign relative weights to
the specific factors considered in reaching its determination. In addition,
individual members of the Promedix board may have given different weights to
different factors. Based on the factors outlined above, the Promedix board
determined that the merger is fair to and in the best interests of Promedix and
its stockholders. In view of the wide variety of factors considered, the
Promedix board did not find it practicable to, and did not, quantify or
otherwise assign relative weights to the specific factors considered.

   THE PROMEDIX BOARD HAS UNANIMOUSLY DETERMINED THAT THE MERGER IS FAIR TO AND
IN THE BEST INTERESTS OF PROMEDIX AND ITS STOCKHOLDERS AND UNANIMOUSLY
RECOMMENDS THAT YOU VOTE FOR THE APPROVAL AND ADOPTION OF THE MERGER AGREEMENT.

   See "Background of the Merger" on page 37, "Material U.S. Federal Income Tax
Consequences" on page 48 and "Comparative Stock Prices Data and Dividend
History" on page 66.

Reasons of Chemdex for the Merger; Recommendation of the Board of Directors of
Chemdex

   At a meeting of the Chemdex board of directors held on September 21, 1999,
the Chemdex board determined that the acquisition of Promedix was in keeping
with its corporate strategy of complementing its internal growth with
acquisitions that are likely to benefit from leveraging Chemdex's technology,
services and operations expertise when combined with Chemdex's existing
operations.

   In reaching its decision to approve the merger, the Chemdex board considered
the following material factors:

  . the expectation that Promedix's online healthcare specialty products
    business, management team and employees could be readily integrated with
    Chemdex's operations, enabling the combined company to broaden its served
    markets;

  . that the merger, before restructuring and similar charges, and assuming
    the realization of certain expected benefits, including accelerated time
    to market, cost savings and other synergies would enhance the combined
    company's position in the general online business-to-business e-commerce
    market;

  . the belief that the combined company will be able to achieve economies by
    scaling and leveraging Chemdex's technology, customer service,
    professional service and account development processes in Promedix's
    specialty healthcare products market; and

  . the detailed financial and pro forma analysis and other information with
    respect to the companies presented by Morgan Stanley to the Chemdex board
    of directors, including Morgan Stanley's opinion that the consideration
    to be paid by Chemdex pursuant to the merger agreement is fair from a
    financial point of view to Chemdex as of the date of the opinion.

   In view of the variety of factors considered in connection with the
evaluation of the merger, the Chemdex board did not find it practical to and
did not quantify or otherwise assign relevant weights to specific factors

                                       39
<PAGE>

considered in reaching its determination. After detailed consideration of these
factors, the Chemdex board concluded that the potential benefits of the merger
outweighed these considerations and determined that the merger was fair to and
in the best interests of Chemdex and its stockholders.

   The above discussion of the information and factors considered by the
Chemdex board is not exhaustive and does not include all factors considered by
the Chemdex board. In view of the variety of factors considered in connection
with its evaluation of the merger, the Chemdex board did not find it
practicable to, and did not, quantify or otherwise assign relative weights to
the specific factors considered in reaching its determination. In addition,
individual members of the Chemdex board may have given different weights to
different factors. Based on the factors outlined above, the Chemdex board
determined that the merger is fair to and in the best interests of Chemdex and
its stockholders.

   THE CHEMDEX BOARD HAS DETERMINED THAT THE MERGER IS FAIR TO AND IN THE BEST
INTERESTS OF CHEMDEX AND ITS STOCKHOLDERS AND RECOMMENDS THAT YOU VOTE FOR THE
APPROVAL AND ADOPTION OF THE MERGER AGREEMENT.

   See "Background of the Merger" on page 37, "Material U.S. Federal Income Tax
Consequences" on page 48 and "Comparative Stock Prices Data and Dividend
History" on page 66.

Opinion of Financial Advisor to Chemdex

   Under an engagement letter dated August 31, 1999, Chemdex retained Morgan
Stanley to provide it with financial advisory services and a financial fairness
opinion in connection with the merger. The Chemdex board of directors selected
Morgan Stanley to act as Chemdex's financial advisor based on Morgan Stanley's
qualifications, expertise and reputation and its knowledge of the business and
affairs of Chemdex. At the meeting of the Chemdex board on September 21, 1999,
Morgan Stanley rendered its oral opinion, subsequently confirmed in writing,
that as of September 21, 1999, based upon and subject to the various
considerations set forth in the opinion, the consideration to be paid by
Chemdex pursuant to the merger agreement is fair from a financial point of view
to Chemdex.

   The full text of the written opinion of Morgan Stanley dated September 21,
1999 that is attached as Annex C to this document sets forth, among other
things, the assumptions made, procedures followed, matters considered and
limitations on the scope of the review undertaken by Morgan Stanley in
rendering its opinion. Chemdex stockholders are urged to, and should, read the
opinion carefully and in its entirety. Morgan Stanley's opinion is directed to
the Chemdex board and addresses only the fairness of the consideration to be
paid by Chemdex pursuant to the merger agreement from a financial point of view
to Chemdex as of the date of the opinion. It does not address any other aspect
of the merger and does not constitute a recommendation to any holder of Chemdex
common stock as to how to vote at the Chemdex special meeting. The summary of
the opinion of Morgan Stanley set forth in this document, while materially
complete, is qualified in its entirety by reference to the full text of the
opinion.

   In connection with rendering its opinion, Morgan Stanley, among other
things:

  . reviewed certain publicly available financial statements and other
    information of Chemdex;

  . analyzed certain financial projections relating to Promedix prepared by
    the management of Promedix;

  . reviewed certain internal financial statements and other financial and
    operating data concerning Chemdex and Promedix prepared by the
    managements of Chemdex and Promedix, respectively;

  . discussed the past and current operations and financial condition and the
    prospects of Promedix, including information relating to certain
    strategic, financial and operational benefits anticipated from the
    merger, with senior executives of Promedix;

  . discussed the past and current operations and financial condition and the
    prospects of Chemdex, including information relating to certain
    strategic, financial and operational synergies and benefits anticipated
    from the merger, with senior executives of Chemdex;

                                       40
<PAGE>

  . reviewed the pro forma impact of the merger on the earnings per share and
    balance sheet of Chemdex;

  . reviewed the reported prices and trading activity of the Chemdex common
    stock;

  . reviewed the stock prices and trading activity of certain other publicly-
    traded companies comparable to Promedix and Chemdex;

  . reviewed the financial terms, to the extent publicly available, of
    certain comparable acquisition transactions;

  . reviewed and discussed with the senior managements of Chemdex and
    Promedix the strategic rationale for the merger;

  . participated in negotiations and discussions among representatives of
    Chemdex and Promedix and their legal advisors;

  . reviewed the draft merger agreement and certain related documents; and

  . performed such other analysis and considered such other factors as Morgan
    Stanley deemed appropriate.

   In rendering its opinion, Morgan Stanley assumed and relied upon, without
independent verification, the accuracy and completeness of the information
reviewed by it for the purposes of its opinion. With respect to the internal
financial statements and other financial and operating data and estimates of
the strategic, financial and operational benefits anticipated from the merger
provided by Chemdex and Promedix, Morgan Stanley assumed that they have been
reasonably prepared on bases reflecting the best currently available estimates
and judgments of the prospects of Chemdex and Promedix, respectively. Morgan
Stanley relied upon the assessment by the managements of Chemdex and Promedix
of their ability to retain key employees of Promedix. Morgan Stanley also
relied upon, without independent verification, the assessment by the
managements of Chemdex and Promedix of:

  . the strategic and other benefits expected to result from the merger;

  . Promedix's technologies, products and intellectual property;

  . the timing and risks associated with the integration of Chemdex and
    Promedix; and

  . the validity of, and risks associated with, Chemdex's and Promedix's
    existing and future technologies, products and intellectual property.

   Morgan Stanley did not make any independent valuation or appraisal of the
assets, liabilities, technologies and intellectual property of Promedix, nor
was it furnished with any such appraisals. In addition, Morgan Stanley assumed
that the merger will be treated as a tax-free reorganization pursuant to the
Internal Revenue Code of 1986 and will be consummated in accordance with the
terms set forth in the merger agreement. Morgan Stanley's opinion is
necessarily based on financial, economic, market and other conditions as in
effect on, and the information made available to it as of September 21, 1999.

   The following is a brief summary of certain of the analyses performed by
Morgan Stanley in connection with its oral opinion and the preparation of its
opinion letter dated September 21, 1999. Certain of these summaries of
financial analyses include information presented in tabular format. In order to
understand fully the financial analyses used by Morgan Stanley, the tables must
be read together with the text of each summary. The tables alone do not
constitute a complete description of the financial analyses.

   Comparative Stock Price Performance. Morgan Stanley reviewed the recent
stock price performance of Chemdex and compared its performance with that of
four groups of companies, as well as the S&P 500 Index and the Morgan Stanley
High Technology Index.

                                       41
<PAGE>

The first group (the Internet Procurement Index) included:

  -- Ariba
  -- VerticalNet
  -- CommerceOne
  -- pcOrder

The second group (the e-Commerce Index) included:

  -- Amazon.com
  -- eBay
  -- Drugstore.com
  -- Insweb
  -- Allscripts
  -- Claimsnet.com

The third group (the Connectivity Index) included:

  -- Careinsite
  -- Healtheon
  -- Cybear

The fourth group (the Content Providers Index) included:

  -- Drkoop.com
  -- Mediconsult.com
  -- Onhealth Network

   As of September 17, 1999, the closing price of the Chemdex common stock was
$21.13, and Morgan Stanley observed the following:
<TABLE>
<CAPTION>
                                                            Indexed Price Change
                                                              Since Chemdex's
                                                               IPO (7/27/99)
                                                            --------------------
   <S>                                                      <C>
   Chemdex.................................................           41%
   Internet Procurement Index..............................           31%
   e-Commerce Index........................................           24%
   Morgan Stanley High Technology Index....................           11%
   S&P 500 Index...........................................          (2)%
   Connectivity Index......................................         (12)%
   Content Providers Index.................................         (29)%
</TABLE>

                                       42
<PAGE>

   Peer Group Comparison. Morgan Stanley compared certain financial information
of Chemdex and Promedix with publicly available information for the companies
comprising the Internet Procurement Index, the e-Commerce Index, the
Connectivity Index and the Content Providers Index. For Promedix, Morgan
Stanley examined two cases: a case prepared by the management of Promedix
(Management Case) and a case in which certain operational assumptions were
reduced by approximately 25% from the Management Case (Adjusted Case). Based on
estimates from securities research analysts, with median values shown except
for Chemdex, implied aggregate values for Promedix based on the Management Case
and Adjusted Case, and the closing price of Chemdex common stock on September
17, 1999 of $21.13, such analysis showed that as of September 17, 1999:

<TABLE>
<CAPTION>
                                                        Aggregate Value/Revenue
                                                        ------------------------
                                                             Calendar Year
                                                        ------------------------
                                                           1999E        2000E
                                                        ------------ -----------
<S>                                                     <C>          <C>
Chemdex................................................        28.7x        4.7x
Internet Procurement Index.............................       115.8x       51.5x
e-Commerce Index.......................................        28.1x       10.9x
Connectivity Index.....................................        37.4x       22.2x
Content Providers Index................................        36.2x       11.1x
Promedix Management Case...............................           NM        6.1x
Promedix Adjusted Case.................................           NM        7.9x
</TABLE>

   No company utilized in the peer group comparison analysis is identical to
Chemdex or Promedix. In evaluating the peer groups, Morgan Stanley made
judgments and assumptions with regard to industry performance, general
business, economic, market and financial conditions and other matters, many of
which are beyond the control of Chemdex and Promedix, such as the impact of
competition on the businesses of Chemdex and Promedix and the industry
generally, industry growth and the absence of any adverse material change in
the financial condition and prospects of Chemdex and Promedix or the industry
or in the financial markets in general. Mathematical analysis (such as
determining the average or median) is not in itself a meaningful method of
using peer group data.

   Analysis of Selected Precedent Transactions. Morgan Stanley compared the
publicly available statistics for selected transactions in the Internet
industry to the relevant financial statistics for Promedix based on the value
of Promedix implied by the closing share price for Chemdex common stock on
September 17, 1999. Among eleven selected Internet merger transactions, the
median ratio of aggregate value to the estimated calendar year 2000 revenue,
based on equity research estimates, was 9.8. Among 29 early stage Internet
private company acquisitions, the median ratio of aggregate value to the
estimated last post money valuation, was 5.0. This compares to the following:

<TABLE>
<CAPTION>
                              Promedix Aggregate Value to
       ---------------------------------------------------------------------------
                Calendar Year 2000
                Estimated Revenues                              Last Post Money Valuation
       --------------------------------------------------------------------------
     <S>                                <C>  <C>                             <C>
       Selected Internet Transactions:  9.8x Selected Internet Transactions: 5.0x
       Promedix Management Case:        6.1x Promedix Transaction Price:     2.7x
       Promedix Adjusted Case:          7.9x
</TABLE>

   No company utilized in the transactions analysis as a comparison is
identical to Chemdex or Promedix. In evaluating the transactions, Morgan
Stanley made judgments and assumptions with regard to industry performance,
general business, economic, market and financial conditions and other matters,
many of which are beyond control of Chemdex and Promedix, such as the impact of
competition on the business of Chemdex and Promedix and the industry generally,
industry growth and the absence of any adverse material change in the financial
condition and prospects of Chemdex and Promedix or the industry or in the
financial markets in general. Mathematical analysis (such as determining the
average or median) is not in itself a meaningful method of using precedent
transactions data.

                                       43
<PAGE>

   Discounted Equity Value. Morgan Stanley performed an analysis of the present
value of the implied value of Promedix on a stand alone basis based on
Promedix's future equity value. Morgan Stanley observed the following for the
calendar year 2002:

<TABLE>
<CAPTION>
                                          Promedix Fully Converted Equity Value
                                       -------------------------------------------
     Next Twelve Months       Discount   Management      Adjusted
 Aggregate Value to Revenues   Rates        Case           Case      Sensitivities
 ---------------------------  -------- -------------- -------------- -------------
                                                     ($ in millions)
 <S>                          <C>      <C>            <C>            <C>
         2.0x-4.0x             35%-50% $554 to $1,371 $426 to $1,054 $212 to $842
 Implied Annual Growth Rate
  from Calendar
 Year 2000 Estimated
  Revenue:                                  282%           235%      137% to 200%
</TABLE>

   Morgan Stanley performed an analysis of the present value per share of the
implied value of Chemdex on a standalone basis. Morgan Stanley observed the
following, based on a range of revenue estimates based on Morgan Stanley equity
research estimates for the calendar years 2001 and 2002:

<TABLE>
<CAPTION>
                                                          Chemdex
                                                 Fully Diluted Equity Value
    Next Twelve Months          Discount     ----------------------------------
Aggregate Value to Revenues       Rates           CY2001           CY2002
- ---------------------------  --------------- ---------------- -----------------
<S>                          <C>             <C>              <C>
        4.0x-10.0x               35%-50%     $21.51 to $80.47 $27.47 to $120.40

   Preliminary IPO Valuation. Morgan Stanley performed an analysis of the
estimated IPO valuation of Promedix based on aggregate value as a multiple of a
range of estimated calendar year 2001 revenues. Morgan Stanley observed the
following implied IPO valuation, assuming revenue multiples of approximately
2.5 to 4.5:

<CAPTION>
                                 Present Value of Current
                              Promedix Stockholders' Equity
                             --------------------------------
      Multiple Range         Management Case  Adjusted Case
      --------------         --------------- ----------------
                                     ($ in millions)
<S>                          <C>             <C>              <C>
         2.5x-4.5x            $220 to $410   $    200 to $400
</TABLE>

   Relative Contribution Analysis. Morgan Stanley analyzed the pro forma
contribution of Chemdex and Promedix to the combined company assuming
consummation of the merger and based on estimates of certain financial metrics
such as revenue and gross profit from securities research analysts for Chemdex,
management estimates for Promedix and the Chemdex closing share price as of
September 17, 1999. The analysis showed, among other things, the following:
<TABLE>
<CAPTION>
                             Management Case                   Adjusted Case
                         ----------------------------     ----------------------------
                         % Pro Forma Contribution         % Pro Forma Contribution
                         ----------------------------     ----------------------------
                           Chemdex         Promedix         Chemdex         Promedix
                         ------------    ------------     ------------    ------------
<S>                      <C>             <C>              <C>             <C>
Projected Calendar Year
 2000
  Revenue...............             75%             25%              80%             20%
  Gross Profit..........             74%             26%              78%             22%
Projected Calendar Year
 2001
  Revenue...............             58%             42%              64%             36%
  Gross Profit..........             62%             38%              68%             32%
Projected Calendar Year
 2002
  Revenue...............             51%             49%              57%             43%
  Gross Profit..........             59%             41%              65%             35%
Projected Calendar Year
 2003
  Revenue...............             44%             56%              51%             49%
  Gross Profit..........             54%             46%              60%             40%
Promedix Transaction
 Price..................             75%             25%              75%             25%
</TABLE>

                                       44
<PAGE>

   Pro Forma Merger Analysis. Morgan Stanley analyzed the pro forma impact of
the merger on the combined company's projected gross profit for calendar year
1999 and 2000. Such analysis was based on gross profit projections by
securities research analysts for Chemdex and the Management Case and the
Adjusted Case for Promedix.

  . Morgan Stanley observed that the merger, under the Management Case, would
    result in gross profit dollar accretion for Chemdex, prior to giving
    effect to any synergies, of 1% for calendar year 2000 and 20% for
    calendar year 2001.

  . Morgan Stanley observed that the merger, under the Adjusted Case, would
    result in gross profit dilution for Chemdex, prior to giving effect to
    any synergies, of 5% for calendar year 2000 and gross profit accretion of
    6% for calendar year 2001.

   The preparation of a fairness opinion is a complex process and is not
necessarily susceptible to partial analysis or summary description. In arriving
at its opinion, Morgan Stanley considered the results of all of its analyses as
a whole and did not attribute any particular weight to any analysis or factor
considered by it. Furthermore, Morgan Stanley believes that selecting any
portion of its analyses, without considering all analyses, would create an
incomplete view of the process underlying its opinion. In addition, Morgan
Stanley may have given various analyses and factors more or less weight than
other analyses and factors, and may have deemed various assumptions more or
less probable than other assumptions, so that the ranges of valuations
resulting from any particular analysis described above should not be taken to
be Morgan Stanley's view of the actual value of Chemdex or Promedix. In
performing its analyses, Morgan Stanley made numerous assumptions with respect
to industry performance, general business and economic conditions and other
matters, many of which are beyond the control of Chemdex or Promedix. Any
estimates contained in Morgan Stanley's analyses are not necessarily indicative
of future results or actual values, which may be significantly more or less
favorable than those suggested by such estimates.

   The analyses performed were prepared solely as part of Morgan Stanley's
analysis of the fairness of the consideration to be paid pursuant to the merger
agreement from a financial point of view to Chemdex and were conducted in
connection with the delivery of the Morgan Stanley opinion. The analyses do not
purport to be appraisals or to reflect the prices at which Chemdex or Promedix
might actually be sold.

   The consideration pursuant to the merger agreement was determined through
arm's-length negotiations between Chemdex and Promedix and was approved by the
Chemdex board of directors. Morgan Stanley provided advice to Chemdex during
such negotiations; however, Morgan Stanley did not recommend to Chemdex any
specific consideration to be paid or that any specific consideration to be paid
constituted the only appropriate consideration to be paid for the merger.

   In addition, Morgan Stanley's opinion and presentation to the Chemdex board
of directors was one of many factors taken into consideration by Chemdex's
board of directors in making its decision to approve the merger. Consequently,
the Morgan Stanley analyses as described above should not be viewed as
determinative of the opinion of the Chemdex board of directors with respect to
the consideration or of whether the Chemdex board would have been willing to
agree to a different consideration to be paid.

   The Chemdex board retained Morgan Stanley based upon Morgan Stanley's
qualifications, experience and expertise. Morgan Stanley is an internationally
recognized investment banking and advisory firm. Morgan Stanley, as part of its
investment banking business, is continuously engaged in the valuation of
businesses and securities in connection with mergers and acquisitions,
negotiated underwritings, competitive biddings, secondary distributions of
listed and unlisted securities, private placements and valuations for
corporate, estate and other purposes. In the past, Morgan Stanley and its
affiliates have provided financing services for Chemdex and have received fees
for the rendering of these services. In the ordinary course of Morgan Stanley's
trading and brokerage activities, Morgan Stanley or its affiliates may at any
time hold long or short positions, may trade or otherwise effect transactions,
for its own account or for the account of customers in the equity securities of
Chemdex or any other parties involved in the transaction.


                                       45
<PAGE>

   Under the engagement letter, Morgan Stanley provided financial advisory
services and a financial fairness opinion in connection with the merger, and
Chemdex agreed to pay Morgan Stanley a customary fee. Chemdex has also agreed
to reimburse Morgan Stanley for its expenses incurred in performing its
services. In addition, Chemdex has also agreed to indemnify Morgan Stanley and
its affiliates, their respective directions, officers, agents and employees and
each person, if any controlling Morgan Stanley or any of its affiliates against
certain liabilities and expenses, including certain liabilities under the
federal securities laws, arising out of Morgan Stanley's engagement.

Interests of Certain Persons in the Merger

 General

   Certain Promedix executive officers and certain members of the Promedix
board of directors will receive benefits as a result of the merger that will be
in addition to or different from their interests as stockholders of Promedix
generally. These include, among other things, provisions in the merger
agreement relating to indemnification and severance benefits for members of
Promedix's board and management. The Promedix board was aware of these
interests and considered them, among other matters, in approving the merger
agreement and the merger.

 Employment Agreements

   In connection with the merger agreement, several senior officers of Promedix
have entered into employment agreements with Chemdex. Below is a chart listing
each officer's position and annual compensation:

<TABLE>
<CAPTION>
                                                                           Annual    Annual
         Person                             Position                    Compensation  Bonus
         ------                             --------                    ------------ -------
                                       (at Promedix, as a
                                     subsidiary of Chemdex)
<S>                      <C>                                            <C>          <C>
William C. Klintworth... Chief Executive Officer                          $150,000
J. Barrie Keiser........ President and Chief Operating Officer            $200,000   $50,000
Thomas J. Sherry........ Senior Vice President, Sales and Service         $180,000   $50,000
Henry M. Clanton........ Vice President, Vendor Relations                 $100,000
Stephen J. Woodard...... Vice President, Buyer Relations                  $100,000
Bradford Bond........... Vice President, Marketing and Public Relations   $100,000
Jamie Locke............. Vice President, Technology                       $100,000
</TABLE>

   The employment agreements also provide that Chemdex will pay severance
benefits equal to the greater of six months salary or $100,000 in the event of
termination without cause or as a result of a constructive termination. In
consideration for the commitments to him, each individual listed above has
agreed for one year following his termination of employment from Chemdex for
any reason he will not:

  . own or participate in any business which competes with Chemdex;

  . solicit any Chemdex employee to leave the employ of Chemdex; or

  . solicit or interfere with any customer of Chemdex.

 Acceleration of Stock Options

   All options held by the 43 employees of Promedix's subsidiary, Pro Med Co.,
Inc., which is being sold prior to the closing of the merger, will be reduced
by one half and such remaining options will immediately become 100% vested upon
the sale of such subsidiary. Options held by Brad Brewer and Barrie Brewer will
be reduced by two thirds and the remaining portion will become 100% vested upon
the sale of such subsidiary.

                                       46
<PAGE>

 CMGI

   CMGI and/or its affiliates beneficially own 2,728,357 shares of Chemdex
common stock, representing approximately 8.3% of the outstanding Chemdex common
stock, and 3,996,800 shares of Promedix preferred stock, representing
approximately 42.3% of the outstanding Promedix capital stock. Following
consummation of the merger, CMGI and its affiliates will beneficially own
approximately 18.0% of the outstanding Chemdex common stock. Jonathan D.
Callaghan is a general partner of the CMGI affiliate, CMG@Ventures, and is a
member of both the Chemdex board of directors and Promedix board of directors.

 Election of Directors

   Upon closing of the merger, William C. Klintworth and one outside director
to be mutually agreed upon will become members of Chemdex's Board of Directors.

 Stock and Options Held by Promedix Executive Officers and Non-Employee
 Directors

   As of September 30, 1999, Promedix's directors and executive officers
collectively beneficially owned 3,361,363 shares of Promedix capital stock and
options to acquire an aggregate of 291,667 shares of Promedix common stock,
which upon consummation of the merger will represent approximately 7.6% of the
combined company's outstanding capital stock.

 Indemnification

   Under the merger agreement, Chemdex has agreed that, from and after the
effective time of the merger, Chemdex will cause Promedix to fulfill and honor
in all respects the obligations of Promedix under (1) any indemnification
agreements that exist between Promedix and its officers and directors at the
effective time of the merger and (2) any indemnification provisions under
Promedix's certificate of incorporation or bylaws that are in effect on the
date of the merger agreement.

Indemnification and Escrow

   Under the merger agreement, the Promedix stockholders, other than dissenting
stockholders who exercise rights of appraisal under Section 262 of the Delaware
General Corporation Law who do not receive Chemdex common stock in the merger,
will be deemed to have agreed personally to indemnify Chemdex and its officers,
directors and affiliates against all claims, losses, and liabilities, incurred
as a result of any breach of a representation, warranty, covenant or agreement
of Promedix contained in the merger agreement that occurs or becomes known to
Chemdex within one year of the closing in excess of $150,000. This obligation
to indemnify Chemdex is limited to no more than 10% of the total number of
shares of Chemdex common stock issued in the merger. An escrow arrangement will
be established at closing to hold these shares of Chemdex common stock. The
escrow agreement is attached as Annex B to this proxy statement. The escrow and
indemnification obligations will end one year after closing. At that time, if
Chemdex has not made a claim for the escrowed shares, the escrowed shares will
be released to the former Promedix stockholders.

   The total amount available for indemnification may not exceed the amount
deposited in the escrow fund (referred to below) and no stockholder is required
to indemnify the indemnified parties for an amount greater than his pro rata
share of the Chemdex stock deposited in the escrow fund. The escrow fund is
available to compensate the indemnified parties for any losses. The
stockholders will have no right of contribution from Promedix with respect to
any loss claimed by Chemdex after the closing date. Nothing in the merger
agreement limits the liability of Promedix for any breach of any
representation, warranty or covenant if the merger is not consummated.

   As security for the indemnity referred to above and to provide security to
satisfy any contingencies arising from the representations and warranties of
Promedix, each of the stockholders who received Chemdex common

                                       47
<PAGE>

stock in the merger will be deemed to have received and deposited with U.S.
Bank Trust, National Association, the escrow agent, 10% of their Chemdex shares
(plus any additional shares as may be issued upon any stock split, stock
dividend or recapitalization effected by Chemdex after the closing date with
respect to those shares). The escrow amount will be deposited with the original
escrow agent or another institution acceptable to Chemdex and the stockholder
agents appointed under the escrow agreement to act on behalf of the former
Promedix stockholders. The deposit with the escrow agent constitutes an escrow
fund to be governed by the terms in the escrow agreement. The portion of the
escrow amount contributed on behalf of each stockholder must be proportional to
the total number of shares of Chemdex common stock to which that individual
would otherwise be entitled. The form of escrow agreement is attached to this
prospectus and proxy statement as Annex B. Under the escrow agreement, the
stockholder agent may sell Chemdex shares under certain circumstances, but the
proceeds of the sale must be maintained in the escrow until it expires.

   The escrow amount held under the escrow agreement provides the sole and
exclusive remedy for any and all damages Chemdex suffers as the result of any
breach of the merger agreement or any claim of negligent misrepresentation
against Promedix or the stockholders in connection with the merger agreement or
the merger. The merger agreement does not, however, limit any:

  .  equitable remedies; or

  .  any type of statutory or common law remedy with respect to any actually
     known or intentional breaches of the representations and warranties or
     covenants of Promedix or the Promedix stockholders in the event of
     fraud, provided the remedy may only be pursued against the person who
     committed or authorized the breaches of the representations, warranties
     or covenants.

Voting Agreements

   Concurrently with the execution of the merger agreement, William C.
Klintworth, John B. Benear II, Ed Kuklenski, Barrie Brewer and @Ventures III,
LP, who collectively hold approximately 74.7% of the issued and outstanding
preferred voting stock of Promedix, approximately 77.5% of the issued and
outstanding common voting stock of Promedix and approximately 76.1% of the
combined issued and outstanding preferred and common voting stock of Promedix,
entered into a voting agreement with Chemdex. Each party to the voting
agreement has agreed to vote any shares of Promedix capital stock beneficially
owned by them in favor of approval of the merger agreement, the merger and any
matter that could reasonably be expected to facilitate the merger. The voting
agreement also requires these stockholders to take all reasonable actions
necessary to call a meeting to approve the merger and appoints Chemdex or its
nominee to vote the stockholders' shares of Promedix in any matter permitted or
required by Delaware law.

Affiliate Agreements

   Concurrently with the execution of the merger agreement, each of William C.
Klintworth, J. Barrie Keiser, Thomas J. Sherry, Henry M. Clanton, Stephen J.
Woodard, Bradford Bond and Jamie Locke entered into an affiliate agreement with
Chemdex, in which each of these affiliates agreed not to dispose of any shares
of Chemdex common stock owned by them or acquired in the merger until financial
results covering at least thirty days of operating results of the combined
company formed in the merger have been released to the public. Each affiliate
also made representations and warranties in the affiliate agreement with
respect to their ownership of shares of Chemdex common stock and agreed to the
appointment of the stockholders agent and the indemnification provisions of the
escrow agreement.

Certain Material U.S. Federal Income Tax Consequences

   The following discussion summarizes the material federal income tax
consequences of the merger that are generally applicable to holders of Promedix
capital stock that hold their shares as capital assets, assuming that the
merger is consummated as contemplated herein. This discussion does not deal
with all federal income tax

                                       48
<PAGE>

considerations that may be relevant to particular Promedix stockholders in
light of their specific circumstances, such as stockholders who are dealers in
securities or foreign currency, banks, insurance companies, or tax-exempt
organizations, who are subject to the alternative minimum tax provisions of the
Internal Revenue Code, who hold their shares as a hedge or as part of a
hedging, straddle, conversion or other risk reduction transaction, who are
foreign persons, or who acquired their shares in connection with stock option
or stock purchase plans or in other compensatory transactions. In addition, the
following discussion does not address the tax consequences of transactions
effectuated prior to or after the merger (whether or not such transactions are
in connection with the merger), including without limitation transactions in
which shares of Chemdex common stock were or are acquired or shares of Promedix
capital stock were or are disposed of. Furthermore, no foreign, state or local
tax considerations are addressed herein. The discussion is based on federal
income tax law as currently in effect, which could change at any time (possibly
with retroactive effect).

   ACCORDINGLY, PROMEDIX STOCKHOLDERS ARE URGED TO CONSULT THEIR OWN TAX
ADVISORS AS TO THE SPECIFIC FEDERAL, STATE, LOCAL AND FOREIGN TAX CONSEQUENCES
TO THEM OF THE MERGER AND TAX REPORTING REQUIREMENTS WITH RESPECT THERETO.

   The parties are not requesting a ruling from the Internal Revenue Service in
connection with the merger. As a condition to consummation of the merger,
Venture Law Group, A Professional Corporation, counsel to Chemdex, and Orrick,
Herrington & Sutcliffe LLP, special counsel to Promedix, will deliver opinions
to Chemdex and Promedix, respectively, that the merger will be treated for
federal income tax purposes as a reorganization within the meaning of Section
368(a) of the Internal Revenue Code. The tax opinions will neither bind the IRS
nor preclude the IRS from adopting a contrary position. In addition, the tax
opinions are subject to certain assumptions and qualifications and are based on
the truth and accuracy of certain representations and covenants made by Chemdex
and Promedix in certificates to be delivered to counsel by the respective
managements of Chemdex and Promedix prior to the effective time.

   Provided that the merger qualifies as a reorganization, then the following
federal income tax consequences will result:

  . No gain or loss will be recognized by Promedix stockholders solely as a
    result of their receipt of Chemdex common stock in the merger in exchange
    for Promedix capital stock (except to the extent of cash received in lieu
    of a fractional share).

  . The aggregate tax basis of the Chemdex common stock received in the
    merger (including any fractional share not actually received) will equal
    the aggregate tax basis of Promedix capital stock surrendered in
    exchange.

  . The holding period of the Chemdex common stock received in the merger by
    a Promedix stockholder will include the period during which the
    stockholder held the Promedix capital stock surrendered in exchange,
    provided that the Promedix capital stock is held as a capital asset at
    the time of the merger.

  . A fractional share of Chemdex common stock for which cash is received
    will be treated as if a fractional share of Chemdex common stock had been
    issued in the merger and then redeemed by Chemdex. A Promedix stockholder
    receiving such cash will generally recognize gain or loss upon payment
    equal to the difference (if any) between the amount of cash received and
    the stockholder's tax basis in the fractional share. The gain or loss
    will be a capital gain or loss if, at the time of the merger, the
    Promedix capital stock is held as a capital asset.

  . A Promedix stockholder who exercises dissenters' rights with respect to
    all of the holder's shares of Promedix capital stock will generally
    recognize gain or loss for federal income tax purposes, measured

                                       49
<PAGE>

   by the difference between the amount of cash received and the holder's
   basis in the shares, provided that the payment is neither essentially
   equivalent to a dividend within the meaning of Section 302 of the Code nor
   has the effect of a distribution of a dividend within the meaning of
   Section 356(a)(2) of the Code. The gain or loss will be capital gain or
   loss, provided that the Promedix capital stock is held as a capital asset
   at the time of the merger.

   A successful IRS challenge to the "reorganization" status of the merger
would result in all Promedix stockholders being treated as if they sold their
Promedix capital stock in a fully taxable transaction. In such event, each
Promedix stockholder would recognize gain or loss with respect to each share of
Promedix capital stock surrendered equal to the difference between (i) the fair
market value, as of the effective time of the merger, of the Chemdex common
stock received in exchange and any cash received instead of fractional shares,
and (ii) the stockholder's adjusted tax basis. In such event, a Promedix
stockholder's aggregate basis in the Chemdex common stock so received would
equal its fair market value as of the effective time and the stockholder's
holding period for the Chemdex common stock would begin the day after the
merger.

   Certain noncorporate holders of Promedix capital stock may be subject to
backup withholding at a 31% rate on cash payments received in lieu of
fractional shares of Chemdex common stock. Backup withholding will not apply,
however, to a stockholder who (i) furnishes a correct taxpayer identification
number and certifies that he or she is not subject to backup withholding on the
substitute Form W-9 (or successor form) included in or with the letter of
transmittal to be delivered to Promedix stockholders following consummation of
the merger, (ii) provides a certification of foreign status on Form W-8 (or
successor form), or (iii) otherwise establishes an exemption from backup
withholding. Any amount withheld under these rules will be credited against the
stockholder's federal income tax liability.

   Irrespective of the merger's status as a reorganization, a Promedix
stockholder will recognize gain to the extent shares of Chemdex common stock
received in the merger are treated as received in exchange for services or
property other than solely Promedix capital stock. All or a portion of any such
gain could be taxable as ordinary income. Gain also will be recognized to the
extent a Promedix stockholder is treated as receiving, directly or indirectly,
consideration other than Chemdex common stock in exchange for Promedix capital
stock or to the extent the Promedix capital stock surrendered in the merger is
not equal in value to the Chemdex common stock and cash received in exchange
therefor.

   THE DISCUSSION SET FORTH ABOVE IS INCLUDED FOR GENERAL INFORMATION ONLY. IT
DOES NOT ADDRESS THE STATE, LOCAL OR FOREIGN TAX ASPECTS OF THE MERGER. IN
ADDITION, IT DOES NOT DISCUSS THE FEDERAL INCOME TAX CONSIDERATIONS THAT MAY BE
RELEVANT TO CERTAIN PERSONS, INCLUDING HOLDERS OF OPTIONS OR WARRANTS, AND MAY
NOT APPLY TO CERTAIN HOLDERS SUBJECT TO SPECIAL TAX RULES, INCLUDING HOLDERS
WHO ACQUIRED PROMEDIX COMMON STOCK PURSUANT TO THE EXERCISE OF EMPLOYEE STOCK
OPTIONS OR RIGHTS OR OTHERWISE RECEIVED SUCH STOCK AS COMPENSATION, DEALERS IN
SECURITIES AND FOREIGN HOLDERS.

   EACH PROMEDIX STOCKHOLDER SHOULD CONSULT HIS OR HER OWN TAX ADVISOR WITH
RESPECT TO THE SPECIFIC TAX CONSEQUENCES OF THE MERGER TO HIM OR HER, INCLUDING
THE APPLICATION AND EFFECT OF STATE, LOCAL AND FOREIGN TAX LAWS.

Accounting Treatment

   The merger will be treated as a purchase for accounting and financial
reporting purposes. Under this method of accounting, the assets and liabilities
of Promedix will be recorded on Chemdex's books at their estimated fair market
value with the remaining purchase price reflected as goodwill. For more
information, see the notes to the Unaudited Pro Forma Combined Condensed
Financial Information beginning on page  .

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<PAGE>

Certain Legal Matters

   Chemdex and Promedix have committed to use their reasonable good faith
efforts to obtain necessary regulatory approvals of the merger. The Hart-Scott-
Rodino Antitrust Improvements Act of 1976 may prohibit Chemdex and Promedix
from completing the merger until certain information and materials have been
furnished to the U.S. Federal Trade Commission and the Antitrust Division of
the U.S. Department of Justice and a required waiting period is observed. Even
after the waiting period expires or terminates, the FTC or the Antitrust
Division could take such action under the antitrust laws as it deems necessary
or desirable in the public interest, including seeking divestiture of
substantial assets of Chemdex or Promedix. Neither Chemdex nor Promedix
believes that consummation of the merger will result in a violation of any
applicable antitrust laws. However, there is no assurance that a challenge to
the merger on antitrust grounds will not be made or, if such a challenge is
made, of the result. Chemdex and Promedix do not believe that any additional
material governmental filings in the United States, other than the agreement of
merger in Delaware, are required with respect to the merger.

U.S. Federal Securities Law Consequences

   Recipients of Chemdex common shares issued in connection with the merger can
freely transfer such shares under the U.S. Securities Act of 1933, except that
persons who are deemed to be "affiliates," as such term is defined under the
Securities Act, of Promedix prior to the merger may only sell shares they
receive in the merger in transactions permitted by the resale provisions of
Rule 145 under the Securities Act, or as otherwise permitted under the
Securities Act. Individuals or entities that control, are controlled by, or are
under common control with, Promedix, including directors and certain officers
of Promedix, are typically considered to be affiliates.

   In general, under Rule 145, for one year following the consummation of the
merger, Promedix affiliates will be subject to the following restrictions on
the public sale of Chemdex common shares acquired in the merger:

  . a Promedix affiliate, together with certain related persons, may sell
    only through unsolicited "broker transactions" or in transactions
    directly with a "market maker," as such terms are defined in Rule 144
    under the Securities Act,

  . the number of shares a Promedix affiliate may sell, together with certain
    related persons and certain persons acting in concert, within any three-
    month period for purposes of Rule 145 may not exceed the greater of 1% of
    the outstanding Chemdex common shares or the average weekly trading
    volume of such stock during the four calendar weeks preceding such sale,
    and

  . a Promedix affiliate may sell only if Chemdex remains current with its
    informational filings with the SEC under the Exchange Act.

   After the end of one year from the consummation of the merger, a Promedix
affiliate may sell Chemdex common shares received in the merger without such
manner of sale or volume limitations provided that Chemdex is current with its
Exchange Act informational filings and such Promedix affiliate is not then an
affiliate of Chemdex. Two years after the consummation of the merger, an
affiliate of Promedix may sell such Chemdex common shares without any
restrictions so long as such affiliate had not been an affiliate of Chemdex for
at least three months prior to such sale.

   Pursuant to an escrow agreement between Chemdex and the Promedix
stockholders, the shares of Chemdex common stock to be issued in the merger
will be held in escrow. Ninety percent of the shares will be released from the
escrow on January 22, 2000, the date on which the shares held by certain
Chemdex stockholders will be released from a lock-up agreement executed at the
time of Chemdex's initial public offering. The remaining 10% of the Chemdex
common stock to be issued in the merger will be held in escrow one year after
the consummation of the merger.

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<PAGE>

Dividends

   Chemdex has never paid a dividend on its capital stock. The payment of
dividends by Chemdex in the future will depend on business conditions,
Chemdex's financial condition and earnings and other factors. The merger
agreement restricts each of Promedix and Chemdex from declaring, setting aside,
making or paying any dividend or other distribution in respect of its capital
stock, during the period from the date of the merger agreement until the
earlier of the termination of the merger agreement or the consummation of the
merger.

Stock Market Listing

   The merger agreement provides that the common shares to be delivered in
connection with the merger shall be authorized for quotation on the Nasdaq
National Market upon completion of the Market.

Dissenters' Rights

   If the merger is approved by the required vote at the special meeting of
Promedix stockholders, a holder of record of shares of Promedix common stock
who does not vote in favor of the merger and who follows the procedures set
forth in Section 262 of the Delaware General Corporation Law may be entitled to
exercise dissenters' rights under Delaware Law. If dissenter's rights are
determined to be available in connection with the merger, these rights entitle
the holder to require Promedix to purchase the holder's shares for cash at
their fair market value. The fair market value of the Promedix common stock
will be determined as of the day before the first announcement of the terms of
the merger, excluding any element of value arising from the accomplishment or
expectation of the merger.

   The following is a summary description of the provisions of the applicable
Delaware law. This summary is complete in all material respects but should be
read with the full text of the applicable law, a copy of which is attached
hereto as Annex D. Any holder of shares of Promedix common stock intending to
exercise statutory dissenters' rights is urged to review Annex D carefully and
to consult with legal counsel so as to assure strict compliance with its
provisions.

   A vote in favor of the merger agreement and the merger will constitute a
waiver of dissenters' rights. If a Promedix stockholder delivers a proxy that
has been left blank, the proxy will be voted for the approval and adoption of
the merger agreement, unless the proxy is revoked before the special meeting.
Therefore, any Promedix stockholder that intends to exercise dissenters' rights
and to vote by proxy should not leave the proxy blank. The stockholder should
either vote against the merger or abstain from voting for or against the
approval and adoption of the merger agreement.

 Notification of Approval and Adoption of Merger Agreement

   Within 10 days after approval and adoption of the merger agreement by the
Promedix stockholders, Promedix or Chemdex must mail a notice of the approval
to holders of shares of Promedix common stock which were not voted in favor of
the merger, together with a statement of the price determined by Promedix to
represent the fair market value of the shares for which dissenters' rights
remain available, a brief description of the procedures to be followed in order
for the holder to pursue dissenters' rights, and a copy of Section 262 of the
Delaware General Corporation Law. The statement of price by Promedix
constitutes an offer by Promedix to purchase all shares for which dissenters'
rights remain available at the stated amount. Only a holder of record of shares
of Promedix common stock on the record date (or the holder's duly appointed
representative) is entitled to exercise dissenters' rights.

 Electing Dissenters' Rights

   To exercise dissenters' rights, the record holder of Promedix common stock
must

  . not vote to approve and adopt the merger agreement, and

  . within 20 days after the date the approval notice is mailed to the
    holder, deliver a written demand for purchase demanding that Promedix
    purchase the holder's shares of common stock and a statement as to what
    the holder claims to be the fair market value of such shares.

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<PAGE>

   The statement of the fair market value of the shares of Promedix common
stock constitutes an offer by the stockholder to sell the shares of Promedix at
that price.

   The written demand for purchase must be delivered to Promedix at 448 East
Winchester Avenue, Suite 200, Salt Lake City, Utah 84107.

   If Promedix and the dissenting holder agree upon the purchase price of the
shares, the dissenting holder is entitled to the agreed upon price with
interest thereon at the legal rate on judgments from the date of such
agreement. Payment for the dissenting shares must be made within 30 days after
the later date of such agreement or the date on which all statutory and
contractual conditions to the merger are satisfied, and is subject to surrender
to Promedix of the certificates for the dissenting shares.

 Appraisal Proceeding By Delaware Court

   If Promedix or Chemdex and the record holder of Promedix common stock fail
to agree upon the fair market value of such holder's shares of Promedix common
stock, then within six months after the date of the approval notice from
Promedix, any stockholder who has not voted in favor of approval and adoption
of the merger agreement and who has made a valid written demand for purchase
may file a complaint in the Delaware Court of Chancery requesting a
determination as to whether the shares are dissenting shares or as to the fair
market value of such holder's shares of Promedix common stock, or both.

 Effect of Exercise of Dissenters' Rights on Voting and Right to Dividends

   Any stockholder who has duly exercised dissenters' rights in compliance with
Delaware Law will not, after the effective time of the merger, be entitled to
vote the dissenting shares for any purpose. The dissenting shares will not be
entitled to the payment of dividends or other distributions, other than those
payable or deemed payable to stockholders of record as of the date prior to the
effective time of the merger.

 Loss, Waiver or Withdrawal of Dissenters' Rights

   If a holder of shares of Promedix common stock who demands the purchase of
shares under Section 262 of the Delaware General Corporation Law fails to
perfect, or effectively withdraws or loses the right to such purchase, such
holder will be entitled to receive the consideration otherwise payable pursuant
to the merger.

   Dissenting shares lose their status as dissenting shares if:

  . the merger is abandoned;

  . the shares are transferred prior to their submission for the required
    endorsement;

  . the dissenting stockholder fails to make a timely written demand for
    purchase, along with a statement of fair market value;

  . the dissenting shares are voted in favor of the merger;

  . the dissenting stockholder and Promedix do not agree upon the status of
    the shares as dissenting shares or do not agree on the purchase price,
    but neither Promedix nor the stockholder files a complaint or intervenes
    in a pending action within six months after mailing of the approval
    notice; or

  . with Promedix's consent, the stockholder delivers to Promedix a written
    withdrawal of the stockholder's written demand for purchase.

   Although Section 262 provides that "any stockholder of a corporation of this
State who holds shares of stock on the date of the making of a demand pursuant
to subsection (d) . . .  shall be entitled to an appraisal . . .  of the fair
value of the stockholder's shares of stock . . . ," Delaware courts have
determined that under certain circumstances holders of preferred stock do not
have the right to seek appraisal of their shares. Chancellor

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<PAGE>

Allen stated in the Matter of the Appraisal of Ford Holdings, Inc. Preferred
Stock, 698 A.2d 973, 975 (1997) that "insofar as preferred stock is concerned,
the provisions of Section 262 may be modified by provisions of the certificate
of rights, etc., which define the security." Promedix's certificate of
incorporation provides that in the event of a "change in control," as defined
in the certificate of incorporation, holders of Promedix preferred stock will
have the right to receive a liquidation preference. The merger would constitute
a change in control as the term is defined. Accordingly, although not free from
doubt, the certificate or incorporation of the Promedix may contractually limit
the amount that a preferred stockholder is entitled to receive to the
liquidation preference of the shares which could limit the right of holders of
Promedix preferred stock to seek judicial appraisal of their shares in the
merger.

                                       54
<PAGE>

                      OTHER TERMS OF THE MERGER AGREEMENT

   The following is a brief summary of certain provisions of the Agreement and
Plan of merger, a copy which is attached as Annex A to this proxy statement and
prospectus and is incorporated by reference. This summary is qualified in its
entirety by reference to the full text of the merger agreement.

Effective Time of the Merger

   The closing of the transactions contemplated by the merger agreement will
take place as soon as practicable following the later of (a) the date on which
both Promedix and Chemdex stockholders meetings approving the merger have
occurred, or (b) the second business day after which all of the conditions to
the merger are satisfied or waived, or (c) at such other date as Chemdex and
Promedix agree. See "Other Terms Of The Merger Agreement--Conditions To The
Merger."

   As soon as practicable after the closing, Chemdex and Promedix will file a
certificate of merger with the Secretary of State of the State of Delaware as
provided by the relevant sections of the Delaware General Corporation Law. The
time at which the certificate of merger is filed in Delaware is referred to as
the effective time.

Conversion of Securities

   As a result of the merger and without any action on the part of the Promedix
stockholders, each share of Promedix capital stock issued and outstanding
immediately prior to the effective time, other than shares held by Chemdex or
Promedix or their subsidiaries and shares held by a dissenting holder as to
which appraisal rights have been perfected, will be converted into the right to
receive fully-paid and nonassessable shares of Chemdex common stock, will cease
to be outstanding, and will be canceled and retired, except as described below.
This amount or exchange ratio will be determined by dividing 12,057,366 shares
of Chemdex common stock, the total number of shares of Chemdex common stock to
be issued as a result of this merger, by the number of shares of Promedix
capital stock outstanding and the number of shares of capital stock issuable
upon exercise of outstanding Promedix options and warrants.

   If this merger is approved, the stockholders of Promedix will receive up to
a maximum of 12,057,366 shares of Chemdex common stock, which will represent
approximately 25% of the outstanding common stock of Chemdex following the
merger. Based on the share calculations set forth in the Unaudited Pro Forma
Combined Condensed Financial Statements, each share of Promedix capital stock
would be exchanged for approximately 1.2795 shares of Chemdex common stock. See
Note 1 to Unaudited Pro Forma Combined Condensed Financial Statements, page 73.

   Each holder of a certificate representing any shares of Promedix capital
stock other than shares held by a dissenting stockholder will upon consummation
of the merger cease to have any rights with respect to the Promedix capital
stock, except for the right to receive, without interest, shares of Chemdex
common stock and cash instead of fractional shares, as described below in "No
Fractional Shares," upon the surrender of the certificate. If prior to the
effective time, Chemdex should split or combine the shares of Chemdex common
stock, or pay a stock dividend or other stock distribution in, or in exchange
of shares of Chemdex common stock, or engage in any similar transaction, then
the total number of shares to be issued to the Promedix stockholders will be
appropriately adjusted to reflect such split, combination, dividend, exchange
or other distribution or similar transaction.

Stock Options

   As of the effective time, each of the options to acquire Promedix common
stock outstanding as of the effective date will be converted into an option, or
a new substitute option shall be issued, to purchase the number of shares of
Chemdex common stock, rounded down to the nearest whole share, equal to the
number of

                                       55
<PAGE>

shares of Promedix common stock subject to such option multiplied by the
exchange ratio, at an exercise price per share of Chemdex common stock, rounded
up to the nearest penny, equal to the former exercise price per share of
Promedix immediately prior to the effective time divided by the exchange ratio;
provided that in the case of any Promedix stock option to which Section 421 of
the Internal Revenue Code applies by reason of its qualification under Section
422 of the Internal Revenue Code, the conversion formula shall be adjusted, if
necessary, to comply with Section 424(a) of the Internal Revenue Code. Except
as provided above, the converted or substituted Promedix stock options will be
subject to the same terms and conditions as were applicable to Promedix stock
options immediately prior to the effective time.

   As soon as practicable after the effective time, Chemdex will file one or
more registration statements on Form S-8 under the Securities Act, or
amendments to its existing registration statements on Form S-8 or amendments to
such other registration statements as may be available, in order to register
the shares of Chemdex common stock issuable upon exercise of the converted
Promedix stock options. The consummation of the merger will not be treated as a
termination of employment for purposes of the option plans. The sale of the
fulfillment business, which will occur immediately prior to the consummation of
the merger transaction with Chemdex, will, however, be treated as a termination
of employment for the employees of the fulfillment business. Upon the sale of
the fulfillment business, all options held by fulfillment business employees
will be reduced by one half and such remaining options will immediately become
100% vested upon the sale of such subsidiary. Options held by Brad Brewer and
Barrie Brewer will be reduced by two thirds and the remaining portion will
become 100% vested upon the sale of the fulfillment business. The fulfillment
business employees will have 30 days to exercise their Promedix stock options
(which will become options to purchase Chemdex Common Stock, after adjusting
the exercise price and number of shares based on the exchange ratio, upon
effectiveness of the merger) following the sale of the fulfillment business.
After such date, pursuant to their terms, such options will lapse and will no
longer be exercisable.

Warrants

   As of the effective time, each of the warrants to acquire Promedix capital
stock outstanding (if any) as of the effective date that will by its terms
survive the merger will be converted into a warrant to purchase the number of
shares of Chemdex common stock, rounded down to the nearest whole share, equal
to the number of shares of Promedix capital stock subject to such warrant
multiplied by the exchange ratio. The exercise price per share for each
Promedix warrant will equal the former exercise price per share immediately
prior to the effective time divided by the exchange ratio.

Exchange of Shares; No Fractional Shares

   As soon as reasonably practicable after the effective time, the exchange
agent will mail to each holder of record of Promedix capital stock (1) a letter
of transmittal and (2) instructions for use in effecting the surrender of the
certificates in exchange for certificates representing shares of Chemdex common
stock. Upon surrender of a certificate to the exchange agent together with such
letter of transmittal, duly executed, the holder of the certificate will be
entitled to receive in exchange therefor (1) a certificate representing that
number of whole shares of Chemdex common stock and (2) a check representing the
amount of cash instead of fractional shares, if any, which the holder has the
right to receive in respect of the certificate surrendered. Promedix
stockholders should not send in their certificates until they receive a letter
of transmittal.

   No fractional shares of Chemdex common stock will be issued pursuant to the
merger. Instead, cash adjustments will be paid in an amount equal to the
product of the fraction of a share of Chemdex common stock that would otherwise
be issuable multiplied by the average closing price of Chemdex's common stock
on the Nasdaq National Market for the 10 trading day period ending two trading
days prior to the closing date.

   No dividends on shares of Chemdex common stock will be paid to persons
entitled to receive certificates representing shares of Chemdex common stock
until such persons surrender their certificates. Upon the surrender, the person
in whose name the certificates representing such shares of Chemdex common stock
will

                                       56
<PAGE>

be issued will also receive any dividends that have become payable with respect
to the shares of Chemdex common stock between the effective time and the time
of the surrender. In no event will the person entitled to receive such
dividends be entitled to receive interest on such dividends.

   If any certificates for shares of Chemdex common stock are to be issued in a
name other than that in which the certificate surrendered in exchange therefor
is registered, the person requesting the exchange must (1) pay to the exchange
agent any transfer or other taxes required by reason thereof, or (2) establish
that the tax has been paid or is not applicable.

   At the effective time, the stock transfer books of Promedix will be closed
and no further transfers of shares of Promedix capital stock will be made.

   Neither the exchange agent nor any party to the merger agreement is liable
to a holder of shares of Promedix capital stock for any shares of Chemdex
common stock or dividends or the cash payment for fractional interests
delivered to a public official pursuant to applicable escheat laws.

   In the event that any certificate has been lost, stolen or destroyed, upon
(1) the making of an affidavit of that fact by the person claiming the
certificate to be lost, stolen or destroyed, and (2) if required by Chemdex, in
its discretion, the posting by the person of a bond in the sum as Chemdex may
direct as indemnity, or the other form of indemnity as Chemdex may reasonably
direct, against any claim that may be made against Chemdex with respect to the
certificate, Chemdex will issue or cause to be issued in exchange for the
certificate the number of whole shares of Chemdex common stock and cash instead
of fractional shares into which the shares of Promedix capital stock
represented by the certificate are converted in the merger.

   If holders of Promedix capital stock are entitled to dissent from the merger
and demand appraisal of any the Promedix capital stock in accordance with the
provisions of Section 262 of the Delaware General Corporation Law, any excluded
shares will not be converted, but will from and after the effective time
represent only the right to receive such consideration as may be determined to
be due to the dissenting holder pursuant to the Delaware Law; provided,
however, that each share of Promedix capital stock held by a dissenting holder
who, after the effective time withdraws his demand for appraisal or lose his
rights of appraisal with respect to the shares of Promedix capital stock, in
either case pursuant to the Delaware Law, will not be deemed to be an excluded
share but will be deemed to be converted, as of the effective time, into the
right to receive Chemdex common stock in accordance with the exchange ratio.

Representations and Warranties

   Promedix and Chemdex have made various customary mutual representations and
warranties in the merger agreement about themselves.

   The merger agreement contains certain representations and warranties by
Promedix relating to, among other things:

  . due organization, power and standing;

  . capital structure and ownership of subsidiaries;

  . the authorization, execution, delivery and enforceability of the merger
    agreement, and required consents and approvals and the absence of
    breaches or violations of the certificate of incorporation and bylaws,
    agreements and instruments, and law;

  . financial statements and absence of undisclosed liabilities;

  . tax matters;

  . the absence of certain changes or events;

                                       57
<PAGE>

  . title and related matters;

  . intellectual property rights;

  . employee benefit plans;

  . bank accounts;

  . contracts;

  . compliance with applicable law;

  . labor and employment matters;

  . interested party transactions;

  . employees, independent contractors and consultants;

  . insurance;

  . litigation;

  . governmental authorizations and regulations;

  . subsidiaries;

  . compliance with environmental requirements;

  . trade regulation;

  . year 2000 compliance;

  . corporate documents;

  . no brokers;

  . action by Promedix board of director;

  . termination of other acquisition negotiations;

  . complete disclosure; and

  . the accuracy of information in this proxy statement and prospectus.

   The merger agreement also contains certain representations and warranties by
Chemdex and Popcorn relating to, among other things:

  . due organization, power and standing;

  . capital structure;

  . the authorization, execution, delivery and enforceability of the merger
    agreement, and required consents and approvals and the absence of
    breaches or violations of the certificate of incorporation and bylaws;

  . the filing of required reports with the SEC and financial statements;

  . compliance with applicable law;

  . interim operations of Popcorn;

  . complete disclosure;

  . the accuracy of information in this proxy statement and prospectus;

  . no brokers;

  . actions of the Chemdex board of directors;

  . termination of competitive acquisition negotiations;

                                       58
<PAGE>

  . litigation; and

  . absence of certain changes or events.

Conduct of Business by Promedix

   Promedix agreed to advise Chemdex promptly of any event that would make any
representation or warranty of Promedix contained in the merger agreement untrue
or inaccurate. Promedix also agreed that prior to the effective time it will,
among other things: (a) carry on its business in the usual, regular and
ordinary course in substantially the same manner as previously conducted; (b)
pay its debts and taxes, and pay or perform its other obligations, when due;
and (c) use its reasonable efforts to preserve intact its business
organization, to retain its present officers and key employees, and preserve
its relationships with customers, suppliers, distributors, licensors, licensees
and others having business dealings with it. Promedix also agreed that through
the effective time, it will promptly notify Chemdex of any event or occurrence
not in the ordinary course in its business. In particular, unless the merger
agreement provides otherwise and subject in certain cases to specified
exceptions, Promedix agreed that, prior to the effective time, it will not,
without the prior written consent of Chemdex, among other things:

  . accelerate, amend or change the period of exercisability or the vesting
    schedule of restricted stock or options except as specifically required
    by the terms of such agreements;

  . declare or pay any dividends on or make or agree to make any other
    distributions in respect of any of its capital stock, or split, combine
    or reclassify any of its capital stock or issue or authorize the issuance
    of any other securities, or purchase or otherwise acquire any shares of
    its capital stock except from former employees, directors and consultants
    in accordance with agreements providing for the repurchase of shares in
    connection with any termination of service by such party;

  . issue or sell any shares of its capital stock or securities convertible
    into shares of its capital stock other than: issuance of securities
    issuable upon conversion of Promedix preferred stock or exercise of
    options warrants outstanding on the date of the merger agreement, or the
    repurchase of shares of common stock from terminated employees pursuant
    to the terms of outstanding stock restriction or similar agreements, or
    the grant of options or issuance of restricted stock under the Promedix
    stock option plan in the ordinary course of business in accordance with
    prior practice;

  . acquire or agree to acquire by merging or consolidating with, or by
    purchasing a substantial equity interest in or substantial portion of the
    assets of, or by any other manner, any business or any corporation,
    partnership or other business organization or division, or otherwise
    acquire or agree to acquire any assets;

  . sell, lease, license or otherwise dispose of any of its properties or
    assets which are material, individually or in the aggregate, to the
    business of Promedix, except non-exclusive licenses of Promedix's
    products and services in the ordinary course of business consistent with
    past practice;

  . increase or agree to increase the compensation payable or to become
    payable to its officers or employees (except to non-officer employees in
    the ordinary course of business consistent with past practice),

  . grant any additional severance or termination pay to, or enter into any
    employment or severance agreements with, officers, employees or agents,

  . enter into any collective bargaining agreement,

  . establish, adopt, enter into or amend in any material respect any bonus,
    profit sharing, thrift, compensation, stock option, restricted stock,
    pension, retirement, deferred compensation, employment, termination,
    severance or other plan, trust, fund, policy or arrangement for the
    benefit of any directors, officers or employees;

  . revalue any of its assets, including writing down the value of inventory
    or writing off notes or accounts receivable;


                                       59
<PAGE>

  . incur, in excess of $25,000, any indebtedness for borrowed money or
    guarantee any such indebtedness or issue or sell any debt securities or
    warrants or rights to acquire any debt securities or guarantee any debt
    securities of others;

  . amend or propose to amend its certificate of incorporation or Bylaws;

  . incur or commit to incur any capital expenditures in excess of $50,000 in
    the aggregate or in excess of $25,000 as to any individual matter;

  . lease, license, sell, transfer or encumber or permit to be encumbered any
    asset, Promedix proprietary right or other property associated with the
    business of Promedix, except non-exclusive licenses of Promedix's
    products and services in the ordinary course of business consistent with
    prior practice;

  . enter into any lease or contract for the purchase or sale of any
    property, real or personal, except in the ordinary course of business
    consistent with past practice;

  . fail to maintain its equipment and other assets in good working condition
    and repair, subject only to ordinary wear and tear;

  . change accounting methods;

  . amend or terminate any material contract, agreement or license to which
    it is a party;

  . loan any amount to any person or entity, or guaranty or act as a surety
    for any obligation;

  . waive or release any material right or claim;

  . make or change any tax or accounting election, change any annual
    accounting period, adopt or change any accounting method, file any
    amended return, enter into any closing agreement, settle any tax claim or
    assessment relating to Promedix, surrender any right to claim refund of
    taxes, consent to any extension or waiver of the limitation period
    applicable to any tax claim or assessment relating to Promedix, or take
    any other action or omit to take any action that would have the effect of
    increasing the tax liability of Promedix or Chemdex;

  . take any action or fail to take any action that would cause there to be a
    material adverse change with respect to Promedix;

  . enter into any agreement outside of the ordinary course of business in
    which the obligation of Promedix exceeds $50,000 or shall not terminate
    or be subject to termination for convenience within 180 days following
    execution;

  . enter into any agreement not in the ordinary course of business; or

  . allow any intellectual property deadline, registrations or applications
    to lapse.

   Promedix also agreed that through the effective time, it will afford Chemdex
access to all of its records, and will furnish to Chemdex all information
concerning its business, properties and personnel as Chemdex may reasonably
request; and use its best efforts to satisfy all of the conditions to
consummate the merger and obtain all third-party consents and authorizations
necessary to consummate the merger.

Conduct of Business by Chemdex

   Chemdex agreed to advise Promedix promptly of any event known to Chemdex
that would render any representation or warranty of Chemdex contained in the
merger agreement untrue or inaccurate. Chemdex also agreed that prior to the
effective time it will, among other things:

  . reserve for issuance the maximum number of shares of Chemdex common stock
    issuable upon consummation of the merger;

                                       60
<PAGE>

  . use its best efforts to satisfy all of the conditions to consummate the
    merger and obtain all required consents and authorizations of, and make
    all filings and give all notices to, third parties that are necessary to
    consummate the merger; and

  . cause the shares of Chemdex common stock issuable to the stockholders of
    Promedix in the merger to be authorized for listing on the Nasdaq
    National Market.

   Chemdex agreed that, prior to the effective time, it will not, without the
prior written consent of Promedix, declare or pay any dividends on or make or
agree to make any other distributions (whether in cash, stock or property) in
respect of any of its capital stock; or amend its certificate of incorporation.

   Chemdex further agreed at or after the effective time to:

  . assume all outstanding options and warrants to purchase Promedix capital
    stock,

  . provide Promedix employees with employee benefits that are no less
    favorable than those provided by Chemdex to its similarly situated
    employees;

  . fulfill and honor the obligations of Promedix pursuant to any
    indemnification agreements between Promedix and its directors and
    officers; and

  . maintain a significant presence in Salt Lake City for at least two years
    following the closing of the merger.

   Chemdex also agreed to provide Promedix with a $10 million line of credit
that is secured by Promedix's assets but subordinated to Promedix's and its
subsidiaries' existing secured creditors.

Joint Conduct

   Chemdex and Promedix agreed that prior to the effective time they will,
among other things:

  . jointly prepare and file a proxy statement and prospectus with the
    Commission;

  . convene stockholders' meetings to vote on the merger;

  . maintain the confidentiality of each other's confidential information;
    and

  . use their reasonable good faith efforts to make all necessary filings and
    notifications and obtain all necessary consents, waivers, approvals and
    authorizations required to consummate the merger.

   Chemdex and Promedix also agreed that neither Chemdex, Promedix nor any of
their respective subsidiaries will take, or allow to be taken or fail to take
any action, which act or failure to act would jeopardize qualification of the
merger as a reorganization within the meaning of Section 368(a) of the U.S.
Internal Revenue Code.

No Solicitation

   Until the consummation of the merger or termination of the merger agreement
in accordance with its terms, and except with respect to certain specified
strategic investors, Promedix may not take any action to solicit or initiate
any inquiry, proposal or offer from, or participate in any negotiations with
any other party regarding any acquisition of Promedix stock or assets or any
material portion of the stock or assets of Promedix, or any material license of
Promedix's proprietary rights. Promedix has agreed to notify Chemdex of any
such potential acquisition proposals, including the identity of the persons
making such proposals and, subject to the fiduciary duties of the Promedix
board of directors, the terms of such proposals.

   Until the consummation of the merger or termination of the merger agreement
in accordance with its terms, and except with respect to certain specified
exceptions, Chemdex may not take any action to solicit or initiate any inquiry,
proposal or offer from, or participate in any negotiations with any other party
regarding

                                       61
<PAGE>

any acquisition of the stock or assets or any material portion of the stock or
assets of a direct competitor of Promedix. Chemdex has agreed to notify
Promedix of any such potential acquisition proposals, including the identity of
the persons making such proposals and, subject to the fiduciary duties of the
Chemdex board of directors, the terms of such proposals.

Certain Other Covenants

 Consents; Approvals

   Chemdex and Promedix will each use its reasonable good faith efforts to
obtain all consents, waivers, approvals, authorizations or orders, and Chemdex
and Promedix will make or cause to be made all filings, required in connection
with the authorization, execution and delivery of the merger agreement and the
consummation by each of them of the transactions contemplated thereby.

 Director and Officer Indemnification

   Chemdex has agreed that for acts occurring prior to the effective time, all
rights to indemnification and advancement of expenses existing in favor of the
directors and officers of Promedix under the provisions existing on the date of
the merger agreement, the certificate of incorporation, bylaws and
indemnification agreements of Promedix shall survive the effective time. In
addition, Chemdex has agreed to indemnify and advance expenses to directors and
officers of Promedix to the full extent required or permitted under the
provisions existing on the date of the merger agreement of Promedix's
certificate of incorporation and bylaws and indemnification agreements of
Promedix. See "Interests of Certain Persons in the Merger."

   Chemdex will maintain, with respect to claims arising from facts or events
which occurred before the effective time, officers' and directors' liability
insurance covering directors and officers of Promedix who were covered as of
the date of the merger agreement by Promedix's existing officers' and
directors' liability insurance policies, on terms substantially no less
advantageous to such officers and directors than such existing insurance.

 Notification of Certain Matters

   Chemdex and Promedix will each give each other prompt notice of the
occurrence or non-occurrence of any event which would be reasonably expected to
cause any representation or warranty contained in the merger agreement to be
materially untrue or inaccurate, or any failure of Promedix, Chemdex or Popcorn
materially to comply with or satisfy any covenant, condition or agreement
contained in the merger agreement.

 Further Action/Tax Treatment

   The parties to the merger agreement will use all reasonable good faith
efforts to take, or cause to be taken, all actions and to do all other things
necessary, proper or advisable to consummate and make effective as promptly as
practicable the transactions contemplated by the merger agreement, to obtain in
a timely manner all necessary waivers, consents and approvals and to effect all
necessary registrations and filings, and otherwise to satisfy or cause to be
satisfied all conditions precedent to each of their obligations under the
merger agreement. In addition, Chemdex, Popcorn and Promedix have each agreed
to use their best efforts to cause the merger to qualify as a reorganization
under the provisions of Section 368(a) of the U.S. Internal Revenue Code, as
specified in the merger agreement, and will not, both before and after
consummation of the merger, take any actions which might reasonably be expected
to prevent the merger from so qualifying.

Public Announcements

   Chemdex and Promedix agreed not to issue any press release or make any
public written statement with respect to the merger or the merger agreement
without the prior consent of the other party, except as required by law or the
regulations of the Nasdaq National Market.

                                       62
<PAGE>

Conditions to the Merger

 Conditions to Obligation of Each Party to Effect The Merger

   The obligations of Chemdex and Promedix to effect the merger are subject to
the satisfaction of certain conditions, including, among others:

  . obtaining Chemdex and Promedix stockholder approvals;

  . all authorizations, consents, orders or approvals of, or declarations or
    filings with, and all expirations of waiting periods imposed by, any
    governmental entity which are necessary for the consummation of the
    merger, shall have been filed, occurred or been obtained;

  . the absence of any injunction prohibiting consummation of the merger;

  . the shares of Chemdex common stock to be issued in the merger shall have
    been approved for quotation on the Nasdaq National Market;

  . the registration statement shall have become effective and no stop order
    shall have been issued by the Commission with respect to the registration
    statement;

  . Promedix shall have received an opinion of its counsel, Orrick,
    Herrington & Sutcliffe LLP, and Chemdex shall have received the opinion
    of its counsel, Venture Law Group, each to the effect that the merger,
    for federal income tax purposes, will constitute a "reorganization"
    within the meaning of Section 368(a) of the U.S. Internal Revenue Code;
    and

  . the waiting period applicable to the consummation of the merger under the
    Hart-Scott-Rodino Antitrust Improvement Act of 1976, as amended, shall
    have expired or been terminated.

   The obligation of each of Chemdex and Promedix to effect the merger is also
subject to the satisfaction of the following additional conditions by the other
party, including, among other things:

  . the other party has performed its obligations under the merger agreement
    prior to the effective time and the representations and warranties of the
    other party contained in the merger agreement are true and correct in all
    material respects as of the effective time, except as contemplated by the
    merger agreement; and

  . each of Chemdex and Promedix has received a legal opinion from the other
    party's counsel.

 Additional Conditions To Obligations Of Chemdex And Popcorn

   In addition, Chemdex's and Popcorn's obligation to effect the merger is
subject to the following:

  . no more than 5% of the outstanding shares of Promedix capital stock shall
    have elected to, or continue to have contingent rights to, exercise
    appraisal rights under Delaware Law;

  . an escrow agent and representatives of the Promedix stockholders shall
    have executed and delivered to Chemdex an escrow agreement;

  . the voting agreements, employment agreements, affiliate agreements and
    stock restriction agreements executed and delivered concurrently with the
    execution of the merger agreement shall remain in full force and effect;

  . Promedix shall have obtained all material consents necessary to
    consummate the merger;

  . Promedix shall have received written letters of resignation from each of
    the current members of its board of directors;

  . Promedix shall have closed the sale of its Pro Med Co. subsidiary; and

  . all of Promedix's outstanding convertible debt shall have converted into
    Promedix capital stock or have been repaid.

                                       63
<PAGE>

 Additional Conditions to Obligation of Promedix

   Promedix's obligation to effect the merger is subject to William C.
Klintworth and one outside director to be mutually agreed upon becoming members
of the Chemdex board of directors.

Termination

   The merger agreement may be terminated and the merger abandoned at any time
prior to the effective time, whether before or after approval by the
stockholders of Chemdex and Promedix:

  . by mutual written consent of Chemdex and Promedix;

  . by either Chemdex or Promedix, by giving written notice to the other
    party, if a court or governmental agency prohibits the merger;

  . by either Chemdex or Promedix if the other company breaches in a material
    way its representations, warranties, covenants or agreements and that
    breach is not remedied within 10 business days or cannot be remedied;

  . by either Chemdex or Promedix, if the merger does not close before
    February 29, 2000 because the other company's stockholders do not approve
    the merger or the other company fails to satisfy its conditions to
    closing (unless the failure results primarily from a breach by the other
    party of any representation, warranty, or covenant contained in the
    merger agreement or the other party's failure to fulfill a condition
    precedent to closing or other default); or

  . by either Chemdex or Promedix, if the other party's board of directors
    recommends an alternative transaction that meets certain criteria
    specified in the merger agreement.

   In the event of termination, the merger agreement is of no further effect
and except as specifically provided in the merger agreement and described in
"Cancellation Fees; Expenses" below, there is no liability or obligation on the
part of either Chemdex or Promedix or their respective officers or directors.

Expenses; Cancellation Fees

   Except with respect to the cancellation fee described below, all costs and
expenses incurred in connection with the merger agreement and the transactions
contemplated by the merger agreement (whether or not the merger is consummated)
will be paid by the party incurring such expenses.

   If the merger agreement is terminated by Promedix either (a) because of an
intentional or willful material breach by Chemdex, (b) because Chemdex
recommended an alternative transaction or tender offer described above, or (c)
the required approvals of the Chemdex stockholders shall not have been
obtained, then within two business days after such termination Chemdex shall
pay Promedix a fee equal to $10 million.

   If the merger agreement is terminated by Chemdex either (a) because of an
intentional or willful material breach by Promedix, (b) because Promedix
recommended an alternative transaction or tender offer described above, or (c)
the required approvals of the Promedix stockholders shall not have been
obtained, then within two business days after such termination Promedix shall
pay Chemdex a fee equal to $10 million.

   Payment of the fee by either party is in addition to any other available
legal or equitable remedies. Any amounts that are not paid within two business
days after termination accrue interest at a rate of 9% per annum until paid.

Amendment; Waiver

   The merger agreement may be amended in writing by Chemdex and Promedix at
any time before or after approval by the stockholders of Promedix, but, after
any such approval, no amendment may be made that by law requires the further
approval of the Promedix or Chemdex stockholders.

                                       64
<PAGE>

   At any time prior to the effective time, Chemdex and Promedix may, to the
extent legally allowed, extend the time for the performance of any of the
obligations or the other acts of the other parties hereto, waive any
inaccuracies in the representations or warranties contained in the merger
agreement or in any document delivered pursuant to the merger agreement, and
waive compliance with any of the agreements or conditions contained in the
merger agreement.

Management of Chemdex Upon Consummation of the Merger

   When the merger is complete, Chemdex will continue to be managed by its
current directors and officers. In addition, William C. Klintworth, who is
currently the President and Chief Executive Officer and a director of Promedix,
will become the general manager of the Promedix subsidiary and a director of
Chemdex. One outside director to be mutually agreed upon shall also become a
member of Chemdex's Board of Directors. See "Chemdex Management" on page 117.

                                       65
<PAGE>

               COMPARATIVE STOCK PRICE DATA AND DIVIDEND HISTORY

   The Chemdex common stock is quoted on Nasdaq under the trading symbol
"CMDX." The following table sets forth, for the periods indicated, the
quarterly high and low sale prices per share of Chemdex common stock.

<TABLE>
<CAPTION>
                                                                      Chemdex
                                                                   common stock
                                                                   -------------
                                                                    High   Low
                                                                   ------ ------
   <S>                                                             <C>    <C>
   Calendar 1999
     First Quarter................................................     NA     NA
     Second Quarter...............................................     NA     NA
     Third Quarter................................................ 32.125 16.875
     Fourth Quarter...............................................
</TABLE>

   On September 20, 1999, the last trading day prior to the announcement by
Chemdex and Promedix that they had reached an agreement concerning the merger,
the closing sales price of Chemdex common stock as reported on the Nasdaq
National Market was $22.750 per share. On    ,    , the closing sales price of
Chemdex common stock as reported on the Nasdaq National Market was $    per
share. Based on the   ,   closing sales price of Chemdex common stock and an
exchange ratio of 1.2795, the equivalent per share value of Promedix common
stock as of such date was approximately $  .

   As of September 30, 1999, there were approximately 8,000 stockholders of
record of Chemdex common stock.

   Because the market price of Chemdex common stock is subject to fluctuation,
the market value of the shares of Chemdex common stock that the Promedix
stockholders will receive in the merger may increase or decrease prior to the
merger. PROMEDIX STOCKHOLDERS SHOULD OBTAIN A CURRENT MARKET QUOTATION FOR
CHEMDEX COMMON STOCK.

   Following the merger, Chemdex common stock will continue to be traded on the
Nasdaq National Market under the symbol "CMDX."

   Neither Chemdex nor Promedix has ever paid cash dividends on its capital
stock. Chemdex has no present plans to pay cash dividends on its capital stock.
Under the terms of the merger agreement, Chemdex is not permitted to declare,
set aside, make or pay any dividend or distribution in respect of its capital
stock from the date of the merger agreement until the earlier of the
termination of the merger agreement and the consummation of the merger.

                                       66
<PAGE>

          UNAUDITED PRO FORMA COMBINED CONDENSED FINANCIAL INFORMATION

   The following unaudited pro forma combined financial information for Chemdex
is derived from the Unaudited Pro Forma Combined Condensed Statements of
Operations for the nine months ended September 30, 1999 and for the year ended
December 31, 1998 and the Unaudited Pro Forma Combined Condensed Balance Sheet
as of September 30, 1999 included elsewhere in this proxy statement and
prospectus. These pro forma financial statements give effect to Chemdex's
acquisition of Promedix through a merger and exchange of shares. The exchange
ratio will be determined by dividing 12,057,366, the maximum number of shares
of Chemdex common stock to be issued as a result of this merger, by the sum of
the number of shares of Promedix capital stock outstanding and the number of
shares of capital stock issuable upon exercise of outstanding options and
warrants to purchase Promedix capital stock as of the closing date. In
addition, the pro forma financial statements give effect to (i) the sale by
Promedix of its subsidiary, Pro Med Co., (ii) the repayment and conversion of
Promedix's subordinated convertible notes, and charge related to the
subordinated convertible notes discount, (iii) the conversion of Promedix's
redeemable convertible preferred stock to common stock, (iv) the charge related
to the reduction and acceleration of options held by Pro Med Co. employees and
two officers, and (v) the sale of Promedix Series C preferred stock subsequent
to September 30, 1999.

   The Unaudited Pro Forma Combined Condensed Statements of Operations for the
year ended December 31, 1998 and for the nine months ended September 30, 1999
reflect these transactions as if they had taken place on January 1, 1998 and
January 1, 1999, respectively. The Unaudited Pro Forma Combined Condensed
Balance Sheet gives effect to these transactions as if they had taken place on
September 30, 1999.

   The Unaudited Pro Forma Combined Condensed Statements of Operations combined
Chemdex's historical results of operations for the year ended December 31, 1998
and the unaudited nine months ended September 30, 1999 with Promedix historical
results of operations for the year ended December 31, 1998 and the unaudited
nine months ended September 30, 1999.

   The Chemdex pro forma statements are based upon information set forth in
this proxy statement and prospectus and assumptions included in the
accompanying notes. After consummation of the merger, Chemdex anticipates
completion of the valuations and other studies of the significant assets,
liabilities and business operations of Promedix. Using this information,
Chemdex will make a final purchase price allocation between tangible assets and
liabilities, identifiable intangible assets and goodwill. The impact of these
changes, principally affecting intangible assets and related amortization,
could be material.

   If the merger is approved, the merger will be accounted for using the
purchase method of accounting. Accordingly, Chemdex's cost to acquire Promedix
is calculated to be $315,776,410 assuming a Chemdex common stock price of
$26.125 per share, which is the average of the closing price per share during
the period beginning three days before and ending three days after September
21, 1999, the day the merger was announced. The cost to acquire Promedix will
be allocated to the assets acquired and liabilities assumed according to their
respective fair values, with the excess purchase price being allocated to
goodwill. As noted above, the final allocation of the purchase price is
dependent upon valuations and other studies that are not yet complete.
Accordingly, the purchase price allocation adjustments made in connection with
the development of the Chemdex Pro Forma Statements are preliminary and have
been made solely for the purpose of developing the Chemdex Pro Forma
Statements.

   The $312,296,316 pro forma excess of purchase price over net tangible assets
acquired as of September 30, 1999 is being amortized over a period of two to
three years at a rate of $104,332,105 per year. Goodwill is being amortized
over a three-year life which Chemdex believes is responsive to the rapid rate
of change in the Internet industry and is consistent with other recent mergers
of a comparable nature.

                                       67
<PAGE>

   As a result of Promedix's sale of Pro Med Co., Promedix expects to incur a
loss of $1,390,260 on the sale of Pro Med Co. and incur a charge of $3,201,686
related to the reduction and acceleration of options held by Pro Med Co.
employees and two officers. In addition, Promedix expects to incur a charge of
$2,699,163 for the discount on the subordinated convertible notes when these
notes are repaid or converted. These one-time charges will occur prior to the
consummation of the Promedix merger and will therefore be reflected on
Promedix's financial statements. The Promedix Balance Sheet After Sale of Pro
Med Co. included in the Unaudited Pro Forma Combined Condensed Balance Sheet
includes the effect of these charges. However, the Unaudited Pro Forma Combined
Condensed Statements of Operations do not reflect these one-time charges.

   The Chemdex Pro Forma Financial Statements should be read in conjunction
with the related notes included in this document and the audited and unaudited
financial statements and notes of Chemdex, Promedix and Pro Med Co., included
elsewhere in this document.

   The Chemdex Pro Forma Statements are not necessarily indicative of what the
actual financial results of the combined company would have been had the
transactions described above taken place on January 1, 1998, January 1, 1999 or
September 30, 1999, nor do they purport to indicate results of future
operations.

                                       68
<PAGE>

                                    CHEMDEX

              UNAUDITED PRO FORMA COMBINED CONDENSED BALANCE SHEET

                            As of September 30, 1999

<TABLE>
<CAPTION>
                                                       Promedix
                                        --------------------------------------------------
                                          Promedix                              Promedix
                                           Before                                After
                                          Sale of       Sale of                 Sale of
                                        Pro Med Co.   Pro Med Co.             Pro Med Co.
                                        and Related   and Related             and Related    Pro Forma          Chemdex
                            Chemdex     Transactions  Transactions            Transactions  Adjustments        Pro Forma
                          ------------  ------------  ------------            ------------  ------------      ------------
<S>                       <C>           <C>           <C>                     <C>           <C>               <C>
ASSETS
Current assets:
 Cash and cash
  equivalents...........  $125,562,779  $    987,367  $        -- (13)        $    987,367   $ 4,999,998 (12) $131,550,144

 Accounts receivable,
  net...................     3,629,144     2,143,092   (2,143,092)(9)                  --            --          3,629,144
 Notes receivable from
  related parties ......           --        217,397     (217,397)(9)                  --            --                --
 Inventories............           --      1,931,066   (1,931,066)(9)                  --            --                --
 Other current assets...     3,713,512        99,535      (83,983)(9)               15,552           --          3,729,064
                          ------------  ------------  -----------             ------------  ------------      ------------
 Total current assets...   132,905,435     5,378,457   (4,375,538)(9)            1,002,919     4,999,998       138,908,352
Property and Equipment,
 net                         7,212,190     1,206,340     (328,896)(9)              877,444           --          8,089,634
Intangible and other
 assets.................    14,677,676     2,573,430   (2,512,537)(9)               60,893   312,296,316 (1)   327,034,885
                          ------------  ------------  -----------             ------------  ------------      ------------
 Total assets...........  $154,795,301  $  9,158,227  $(7,216,971)            $  1,941,256  $317,296,314      $474,032,871
                          ============  ============  ===========             ============  ============      ============

LIABILITIES AND
 STOCKHOLDERS' EQUITY
Current liabilities:
 Accounts payable.......  $  4,426,404  $  1,727,957  $(1,396,396)(9)         $    331,561  $        --       $  4,757,965
 Payable to Pro Med
  Co....................           --            --     1,089,599 (9)            1,089,599           --          1,089,599
 Accrued compensation...     2,475,442       349,638     (349,638)(9)                  --            --          2,475,442
 Other accrued
  liabilities...........     7,711,635       138,584     (138,584)(9)                  --      1,000,000 (3)     8,711,635
 Current portion of
  notes payable.........       379,059     1,531,692   (1,531,692)(9)                  --            --            379,059
 Convertible notes, net
  of discount...........           --      2,300,672   (2,300,672)(2)                  --            --                --
                          ------------  ------------  -----------             ------------  ------------      ------------
 Total current
  liabilities...........    14,992,540     6,048,543   (4,627,383)               1,421,160     1,000,000        17,413,700
Notes payable, less
 current portion........       590,234           --           --                       --            --            590,234
Deferred tax liability..           --            --           --                       --      2,040,000 (11)    2,040,000
Redeemable preferred
 stock..................           --      3,738,057          --                 3,738,057    (3,738,057)(4)           --
Stockholders' equity:
 Common Stock...........   189,391,141    23,934,604    4,701,521 (2)(10)       28,636,125   286,140,285 (5)   504,167,551
 Deferred compensation..    (6,926,489)  (17,624,990)         --               (17,624,990)   17,624,990 (8)    (6,926,489)
 Notes receivable from
  stockholders..........    (1,047,047)          --           --                       --            --         (1,047,047)
 Accumulated deficit....   (42,205,078)   (6,937,987) (7,291,109) (5)(9)(10)   (14,229,096)   14,229,096 (6)   (42,205,078)
                          ------------  ------------  -----------             ------------  ------------      ------------
 Total stockholders'
  equity (deficit)......   139,212,527     (628,373)   (2,589,588)              (3,217,961)  317,994,371       453,988,937
                          ------------  ------------  -----------             ------------  ------------      ------------
 Total liabilities and
  stockholders' equity..  $154,795,301  $  9,158,227  $(7,216,971)            $  1,941,256  $317,896,314      $474,032,871
                          ============  ============  ===========             ============  ============      ============
</TABLE>

    See Notes to Unaudited Pro Forma Combined Condensed Financial Statements

                                       69
<PAGE>

                                    CHEMDEX

         UNAUDITED PRO FORMA COMBINED CONDENSED STATEMENT OF OPERATIONS

                      For The Year Ended December 31, 1998

<TABLE>
<CAPTION>
                                                    Pro Forma         Chemdex
                            Chemdex    Promedix    Adjustments       Pro Forma
                          -----------  ---------  -------------    -------------
<S>                       <C>          <C>        <C>              <C>
Net revenues............  $    29,355  $  14,034  $         --     $      43,389
Cost of revenues........       22,105      1,100        308,333(7)       331,538
                          -----------  ---------  -------------    -------------
  Gross Profit (loss) ..        7,250     12,934       (308,333)        (288,149)
Operating expenses:
Research and
 development............    3,439,135        --         420,000(7)     3,859,135
Sales and marketing.....    3,247,136        --       1,065,000(7)     4,312,136
General and
 administrative.........    1,744,898     73,236        140,000(7)     1,958,134
Amortization of
 goodwill...............          --         --     102,398,722(7)   102,398,722
Amortization of deferred
 compensation...........      372,285        --             --           372,285
                          -----------  ---------  -------------    -------------
  Total operating
   expenses.............    8,803,454     73,236    104,023,722      112,900,412
                          -----------  ---------  -------------    -------------
Operating loss..........   (8,796,204)   (60,302)  (104,332,055)    (113,188,561)
Interest expenses.......       (2,620)       --             --            (2,620)
Interest income and
 other, net.............      310,410        398            --           310,808
                          -----------  ---------  -------------    -------------
Income (loss) before
 extraordinary item.....   (8,488,414)   (59,904)  (104,332,055)    (112,880,373)
Extraordinary item......          --      86,204            --            86,204
                          -----------  ---------  -------------    -------------
Net income (loss).......  $(8,488,414) $  26,300  $(104,332,055)   $(112,794,169)
                          ===========  =========  =============    =============
Basic Net income (loss)
 per share:
  Income before
   extraordinary item...  $     (4.79) $   (0.02)                  $      (21.62)
  Extraordinary item....         0.00       0.03                            0.02
                          -----------  ---------                   -------------
  Net income (loss).....  $     (4.79) $    0.01                   $      (21.60)
                          ===========  =========                   =============
Diluted Net income
 (loss) per share:
  Income before
   extraordinary item...  $     (4.79) $   (0.01)                  $      (21.62)
  Extraordinary item....         0.00       0.01                            0.02
                          -----------  ---------                   -------------
  Net income (loss).....  $     (4.79) $    0.00                   $      (21.60)
                          ===========  =========                   =============
Weighted average number
 of shares outstanding
  Basic.................    1,771,508  2,696,228                       5,221,332
  Diluted...............    1,771,508  6,693,028                       5,221,332
</TABLE>


    See Notes to Unaudited Pro Forma Combined Condensed Financial Statements

                                       70
<PAGE>

                                    CHEMDEX

         UNAUDITED PRO FORMA COMBINED CONDENSED STATEMENT OF OPERATIONS

                  For The Nine Months Ended September 30, 1999

<TABLE>
<CAPTION>
                                                       Promedix
                                        -------------------------------------------
                                          Promedix                       Promedix
                                           Before                         After
                                          Sale of       Sale of          Sale of
                                        Pro Med Co.   Pro Med Co.      Pro Med Co.
                                        and Related   and Related      and Related    Pro Forma         Chemdex
                            Chemdex     Transactions  Transactions     Transactions  Adjustments       Pro Forma
                          ------------  ------------  ------------     ------------  ------------    -------------
<S>                       <C>           <C>           <C>              <C>           <C>             <C>
Net revenues............  $ 11,561,238  $ 7,875,993   $(7,875,993)(9)  $       --    $        --     $  11,561,238
Cost of revenues........    10,994,266    5,776,465    (5,776,465)(9)          --         231,250(7)    11,225,516
                          ------------  -----------   -----------      -----------   ------------    -------------
  Gross profit (loss)...       566,972    2,099,528    (2,099,528)             --        (231,250)         335,722
Operating expenses:
 Research and
  development...........    11,397,939      118,568           --           118,568        315,000(7)    11,831,507
 Sales and marketing....    15,315,708    1,574,886    (1,182,859)(9)      392,027        798,750(7)    16,506,485
 General and
  administrative........     7,198,047    3,223,818      (643,181)(9)    2,420,637        105,000(7)     9,723,684
 Amortization of
  goodwill..............           --       202,332           --           202,332     76,799,079(7)    77,001,411
 Amortization of
  deferred
  compensation..........     1,445,305    3,776,288           --         3,776,288            --         5,221,593
                          ------------  -----------   -----------      -----------   ------------    -------------
  Total operating
   expenses.............    35,356,999    8,895,892    (1,826,040)       6,909,852     78,017,829      120,284,680
                          ------------  -----------   -----------      -----------   ------------    -------------
Operating loss..........   (34,790,027)  (6,796,364)     (273,488)      (6,909,852)   (78,249,079)    (119,948,958)
Interest expenses.......      (107,995)    (236,603)       56,786 (9)     (179,817)    (2,699,163)      (2,986,975)
Interest income and
 other, net.............     1,584,751       77,084         1,534 (9)       78,618            --         1,663,369
                          ------------  -----------   -----------      -----------   ------------    -------------
Income (loss) before
 provision for income
 taxes                     (33,313,271)  (6,955,883)     (215,168)(9)   (7,011,051)   (80,948,242)    (121,272,564)
Provision for income
 taxes..................           --       (10,000)       10,000 (9)          --             --               --
                          ------------  -----------   -----------      -----------   ------------    -------------
Net loss................  $(33,313,271) $(6,965,883)  $  (205,168)     $(7,011,051)  $(80,948,242)   $(121,272,564)
                          ============  ===========   ===========      ===========   ============    =============
Basis and diluted net
 loss per share.........  $      (3.33) $     (1.99)                   $     (2.00)                  $       (8.37)
                          ============  ===========                    ===========                   =============
Weighted average shares
 of common stock used in
 computing basic and
 diluted net loss per
 share..................    10,007,174    3,502,209                      3,502,209                      14,488,250
                          ============  ===========                    ===========                   =============
</TABLE>

    See Notes to Unaudited Pro Forma Combined Condensed Financial Statements

                                       71
<PAGE>

                          NOTES TO UNAUDITED PRO FORMA
                    COMBINED CONDENSED FINANCIAL STATEMENTS

   The Chemdex Pro Forma Statements are based upon the financial statements of
Chemdex and of Promedix, combined and adjusted to give effect to: (i) Chemdex's
proposed acquisition of Promedix capital stock through a merger, (ii) the sale
by Promedix of its subsidiary, Pro Med Co., (iii) the repayment and conversion
of Promedix's subordinated convertible notes and the charge related to the
subordinated convertible notes discount, (iv) the conversion of Promedix's
redeemable convertible preferred stock to common stock, (v) the charge related
to the reduction and acceleration of options held by Pro Med Co. employees, an
Officer and Director and (vi) the sale of Promedix Series C preferred stock
subsequent to September 30, 1999.

   The Unaudited Pro Forma Combined Condensed Balance Sheet gives effect to
these transactions as if it had taken place on September 30, 1999 and reflects
the total purchase costs of the fair value of assets and liabilities based on a
preliminary valuation. The Unaudited Pro Forma Combined Condensed Statements of
Operations for the year ended December 31, 1998 and the nine months ended
September 30, 1999 reflect these transactions as if they had taken place on
January 1, 1998.

   On September 21, 1999, Chemdex and Promedix entered into the Agreement and
Plan of Merger pursuant to which 12,057,366 shares of Chemdex common stock will
be issued in exchange for the shares of Promedix capital stock outstanding and
issuable upon exercise of outstanding options, and warrants to purchase
Promedix capital stock as of the closing date. The merger will be accounted for
using the purchase method of accounting. Accordingly, Chemdex's cost to acquire
Promedix, calculated to be approximately $315,776,410 assuming a Chemdex common
stock price of $26.125 per share, which is the average of the closing price per
share during the period beginning three days before and ending three days after
September 21, 1999, the day the merger was announced. The cost to acquire
Promedix will be allocated to the assets acquired and liabilities assumed
according to their respective fair values, with the excess purchase price being
allocated to goodwill. As noted above, the final allocation of the purchase
price is dependent upon valuations and other studies that are not yet complete.
Accordingly, the purchase price allocation adjustments made in connection with
the development of the Chemdex Pro Forma Statements are preliminary and have
been made solely for the purpose of developing the Chemdex Pro Forma
Statements.

   The $312,296,316 pro forma excess of purchase price over net tangible assets
acquired as of September 30, 1999 is being amortized over two to three years at
a rate of $104,332,105 per year. Goodwill is being amortized over a three-year
life which Chemdex believes is responsive to the rapid rate of change in the
Internet industry and is consistent with other recent mergers of a comparable
nature.

   As a result of Promedix's sale of Pro Med Co., Promedix expects to incur a
loss of $1,390,260 on the sale of Pro Med Co. and incur a charge of $3,201,686
related to the reduction and acceleration of options held by Pro Med Co.
employees and two officers. In addition, Promedix expects to incur a charge of
$2,699,163 for the discount on the subordinated convertible notes when these
notes are repaid or converted. These one-time charges will occur prior to the
consummation of the Promedix merger and will therefore be reflected on
Promedix's financial statements. The Promedix Balance Sheet After Sale of Pro
Med Co. included in the Unaudited Pro Forma Combined Condensed Balance Sheet
includes the effect of these charges. However, the Unaudited Pro Forma Combined
Condensed Statements of Operations do not reflect these one-time charges.

   The Chemdex Pro Forma Financial Statements should be read in conjunction
with the related notes included in this document and the audited and unaudited
financial statements and notes of Chemdex, Promedix, and Pro Med Co., included
elsewhere in this document.

   The Chemdex Pro Forma Financial Statements are not necessarily indicative of
what the actual financial results of the combined company would have been had
the transactions described above taken place on January 1, 1998, January 1,
1999 or September 30, 1999 nor do they purport to indicate results of future
operations.

                                       72
<PAGE>

                          NOTES TO UNAUDITED PRO FORMA
              COMBINED CONDENSED FINANCIAL STATEMENTS--(Continued)


   Below is a table of the estimated acquisition cost, purchase price
allocation and annual amortization of the intangible assets acquired:

<TABLE>
<CAPTION>
                                                       Years of       Annual
                                                     Amortization  Amortization
                                                         Life     of Intangibles
                                                     ------------ --------------
   <S>                                 <C>           <C>          <C>
   Estimated Acquisition Cost:
    Estimated Purchase Price.........  $314,776,410
    Acquisition Expenses.............     1,000,000
                                       ------------
     Total Estimated Acquisition
      Cost...........................  $315,776,410
                                       ============
   Purchase Price Allocation:
    Net tangible assets of Promedix
     at September 30, 1999, after
     sale of Pro Med Co. and
     repayment and conversion of
     subordinated convertible notes..  $ (3,217,961)
    Conversion of redeemable
     preferred stock.................     3,738,057
    Sale of Series C stock subsequent
     to September 30, 1999...........     4,999,998
                                       ------------
    Pro forma net tangible assets of
     Promedix at September 30, 1999..     5,520,094
   Intangible assets acquired:
    Assembled workforce..............     1,400,000        2           700,000
    Customer relationships...........     2,800,000        3           933,333
    Supplier relationships...........       900,000        3           300,000
    Goodwill.........................   307,196,316        3       102,398,772
    Deferred tax liability...........    (2,040,000)
                                       ------------
     Total...........................  $315,776,410
                                       ============
</TABLE>

   The unaudited pro forma combined condensed financial statements give effect
to the following pro forma adjustments:

     1. Application of purchase accounting to the Promedix merger, reflecting
  the estimated acquisition cost noted above and the issuance of Chemdex
  common stock. Components of the estimated acquisition cost reflect:

     The purchase price is determined as follows:

<TABLE>
<CAPTION>
                                           Promedix   Chemdex     Fair Value
                                            Shares     Shares   (in thousands)
                                           --------- ---------- --------------
     <S>                                   <C>       <C>        <C>
     Outstanding shares at September 30,
      1999...............................  7,576,339  9,693,958  $253,254,653
     Sales of Series C preferred stock ..    176,429    225,742     5,897,510
     Stock options.......................    991,345  1,268,430    32,915,457
     Warrants............................    333,334    426,502    11,142,364
     Subordinated convertible notes......    346,020    442,734    11,566,426
                                           --------- ----------  ------------
         Totals..........................  9,423,467 12,057,366  $314,776,410
                                           ========= ==========  ============
</TABLE>


                                       73
<PAGE>

                          NOTES TO UNAUDITED PRO FORMA
              COMBINED CONDENSED FINANCIAL STATEMENTS--(Continued)


  .  Acquisition of Promedix capital stock through an exchange of 1.2795
     shares of Chemdex common stock for each share of Promedix capital stock
     or approximately 9,693,958 shares of Chemdex common stock in the
     aggregate. The purchase price was based upon the approximately 9,693,958
     Chemdex shares, multiplied by a per share price of $26.125, the average
     of the closing price per share during the period beginning three days
     before and ending three days after September 21, 1999, the day the
     merger was announced. The merger agreement provides for the merger of
     Promedix with a wholly owned subsidiary of Chemdex, resulting in
     Promedix becoming a wholly-owned subsidiary of Chemdex.

  .  Conversion of approximately 176,429 shares of Promedix Series C
     preferred stock related to Tenet Healthcare Corporation's investment in
     Promedix subsequent to September 30, 1999, or approximately 225,742
     shares of Chemdex common stock, after giving effect to the 1.2795
     exchange ratio in the merger. The purchase price was based upon a
     Chemdex common stock price of $26.125 multiplied by the 225,742 shares.

  .  Conversion of approximately 991,345 outstanding and unexercised options
     exercisable for shares of Promedix common stock into options exercisable
     for an aggregate of approximately 1,268,430 shares of Chemdex common
     stock having the same terms and conditions as the Promedix options,
     after giving effect to the 1.2795 exchange ratio in the merger. The fair
     value of the options assumed is based on the Black-Scholes option
     pricing model using the following assumptions:

<TABLE>
     <S>                                                                <C>
     The fair value of the underlying shares, calculated by taking the
      average Chemdex common stock closing price on September 21,
      1999, the day the merger was announced, and three days prior and
      subsequent to such date.........................................  $26.125
     Expected years until exercise....................................        4
     Expected stock volatility........................................      100%
     Risk free interest rate..........................................        6%
     Expected dividend rate...........................................      --
</TABLE>

  .  Exercise of warrants to purchase 333,334 of Promedix's common stock
     through the retirement of $499,835 of subordinated convertible notes, or
     approximately 426,502 of Chemdex common stock, after giving effect to
     the 1.2795 exchange ratio in the merger. The purchase price was based
     upon a Chemdex common stock price of $26.125 multiplied by the 426,502
     shares.

  .  Conversion of approximately $1,000,000 subordinated convertible notes
     into 346,020 of Promedix common stock or approximately 442,734 shares of
     Chemdex common stock, after giving effect to the 1.2795 exchange ratio
     in the merger. The purchase price was based upon Chemdex common stock
     share price of $26.125 multiplied by the 442,734 shares.

     Components of the purchase price allocation listed above and reflected
  in the Chemdex Pro Forma Statements include the following:

       Tangible assets of Promedix to be acquired principally include cash,
    current and other assets and property and equipment. Liabilities of
    Promedix assumed in the Promedix merger principally include accounts
    payable, and a payable to Pro Med Co.

       The value of customer and supplier relationships was derived by
    attributing historical costs incurred, excluding technology development
    costs, to each of the two respective relationships based upon Promedix
    management's estimation of proportionate resources that had been
    devoted to the development of each of the respective relationships. The
    analysis yielded a valuation of approximately $3,700,000. The asset is
    being amortized on a straight line basis over a three year period.

       The value of the assembled workforce was derived by estimating the
    costs to replace the existing employees, including recruiting and
    hiring costs and training costs for each category of employee. The
    analysis yielded a valuation of approximately $1,400,000 for the
    assembled workforce. The asset is being amortized on a straight line
    basis over a two year period.

                                       74
<PAGE>

                         NOTES TO UNAUDITED PRO FORMA
             COMBINED CONDENSED FINANCIAL STATEMENTS--(Continued)


       The preliminary goodwill allocation is approximately $307,196,316.
    Amortization of goodwill will occur over three years. Chemdex believes
    that a three-year life is responsive to the rapid rate of change in the
    Internet industry and is consistent with other recent mergers of a
    comparable nature.

     2. Promedix is repaying $3,500,000 of the $5,000,000 subordinated
  convertible notes ($2,300,672 net of discounts) from proceeds received from
  the sale of Pro Med Co. In addition, $1,000,000 of the subordinated
  convertible notes is being converted to 346,020 shares of Promedix common
  stock and $499,835 of the subordinated convertible notes is being used to
  pay for the exercise of the warrants to purchase 333,334 shares of Promedix
  common stock outstanding. The $2,699,163 discount on the subordinated
  convertible notes will be recognized in Promedix's financial statements
  when the subordinated notes are converted or repaid. The Promedix Balance
  Sheet After Sale of Pro Med Co. included in the Unaudited Pro Forma
  Combined Condensed Balance Sheet includes the one-time charge related to
  the discount on the subordinated convertible notes. However, the Unaudited
  Pro Forma Combined Condensed Statements of Operations do not reflect this
  one-time charge.

     3. The pro forma adjustment to "Other accrued liabilities" reflects the
  accrual of acquisition costs arising from the merger, estimated to be
  approximately $1,000,000.

     4. The pro forma adjustment to "Redeemable convertible preferred stock"
  reflects the conversion of Promedix's redeemable convertible preferred
  stock ($3,738,057) to common stock.

     5. The pro forma adjustment to "Common stock" reflects the conversion of
  redeemable convertible preferred stock to Promedix common stock
  ($3,738,057), the conversion of $1,000,000 of the subordinated convertible
  notes to common stock, exercise of 333,334 of Promedix warrants outstanding
  in exchange for a $499,835 reduction in the subordinated convertible notes,
  the $3,201,686 related to the acceleration of Pro Med Co. stock options,
  the sale of Promedix Series C preferred stock for $4,999,998, and the
  issuance of Chemdex common stock ($314,776,410) and the elimination of
  Promedix common stock ($42,075,701).

     6. The pro forma adjustment to "Accumulated deficit" reflects the
  elimination of Promedix's accumulated deficit after the sale of Pro Med Co.

     7. The pro forma adjustment is for the amortization of goodwill,
  customer and supplier relationships and assembled workforce.

     8. The pro forma adjustment is to eliminate deferred compensation
  related to Promedix stock options.

     9. Prior to the acquisition of Promedix by Chemdex, Promedix intends to
  sell 100% of the outstanding capital stock of its wholly owned subsidiary,
  Pro Med Co. to an unrelated third party. The loss on the sale of Pro Med
  Co. is estimated at $1,390,260 based on the $3,500,000 purchase price less
  net tangible assets of $3,800,661 and the $1,089,599 Promedix payable to
  Pro Med Co. at September 30, 1999. The Promedix Balance Sheet After Sale of
  Pro Med Co. included in the Unaudited Pro Forma Combined Condensed Balance
  Sheet includes the loss on the sale of Pro Med Co., Inc. However, the
  Unaudited Pro Forma Combined Condensed Statements of Operations do not
  reflect this one-time loss on the sale of Pro Med Co., Inc. The loss on the
  sale of Pro Med Co. will be reflected in Promedix's financial statements
  when the sale of Pro Med Co. is consummated.

     The Unaudited Pro Forma Combined Condensed Statement of Operations for
  the nine months ended September 30, 1999 eliminates Pro Med Co.'s operating
  results for the nine months ended September 30, 1999 due to the sale of Pro
  Med Co. to an unrelated third party. In addition the Unaudited Pro Forma
  Combined Condensed Balance Sheet at September 30, 1999 eliminates Pro Med
  Co.'s assets of $7,216,971 and liabilities of $3,416,310 and establishes a
  $1,089,599 payable to Pro Med Co. due to the sale of Pro Med Co. to an
  unrelated third party.

                                      75
<PAGE>

                          NOTES TO UNAUDITED PRO FORMA
              COMBINED CONDENSED FINANCIAL STATEMENTS--(Continued)


     In the event that, at any time within 3 years of the closing of the sale
  of Pro Med Co., Pro Med Co. elects to merge or sell Pro Med Co. or
  substantially all of the assets of Pro Med Co. to a third party, Chemdex
  shall have a right of first refusal to acquire Pro Med Co. on the same
  terms of the third party offer within 30 days of Chemdex receiving notice
  of the proposed transaction.

     10. As part of Promedix's sale of Pro Med Co., which is being sold prior
  to the closing of the merger, 79,500 options held by Pro Med Co. employees
  will be reduced by one half and such remaining options will immediately
  become 100% vested (39,750). The 250,000 options held by Brad Brewer and
  Barrie Brewer, an officer and director, respectively, will be reduced by
  two thirds and the remaining portion will become 100% vested (83,334). The
  charge for the accelerated vesting of stock options is estimated at
  $3,201,686. The Promedix Balance Sheet After Sale of Pro Med Co. included
  in the Unaudited Pro Forma Combined Condensed Balance Sheet indicates the
  effect of the charge for accelerated options. However, the Unaudited Pro
  Forma Combined Condensed Statements of Operations do not reflect this one-
  time charge. The charge related to the accelerated options will be
  reflected in Promedix's financial statements when the acceleration occurs.

     11. Goodwill has been increased and deferred tax liabilities have been
  recorded in the amount of $2,040,000 to reflect the net effect of book/tax
  basis differences on the acquired intangibles, excluding goodwill. Deferred
  tax assets have been realized based on projected reversal of taxable
  temporary differences and have been netted against deferred tax liabilities
  for purposes the purchase price.

     12. Promedix is selling 176,429 shares of Series C preferred stock
  subsequent to September 30, 1999 for $4,999,998.

     13. Promedix is receiving $3,500,000 of cash for the sale of Pro Med Co.
  In addition Promedix is repaying $3,500,000 of the subordinated convertible
  notes.

                                       76
<PAGE>

                           INFORMATION ABOUT PROMEDIX

Promedix's Business

 Overview

   Promedix is an Internet-based specialty medical product marketplace that
links buyers and suppliers in this highly-fragmented vertical market by
providing a Java-based product research and purchasing system, called the
Specialty Medical Product Exchange. This vertical marketplace, which is in
development, will provide customers the ability to purchase from multiple
specialty medical product suppliers with a single purchase order and offers
integration capability with major legacy systems currently in use by healthcare
institutions.

 History

   Promedix was previously known as MCA HealthPages, Inc. (MCA). MCA conducted
its principal business--providing Web design and hosting services for specialty
medical manufacturing clients--beginning in 1997. Its principals sold the Web
design segment of the business in 1998 to concentrate on electronic commerce.

   In late 1997, MCA developed what it called "Medical Village," the first E-
commerce site on the Web for the procurement of specialty medical products. It
was a precursor to the Specialty Medical Product Exchange, offering full search
capability of specialty medical manufacturers and the ability to directly
communicate with them to facilitate purchases.

   In mid-1998, MCA began to aggressively seek venture capital funding for
Medical Village. MCA received first-round funding from CMG @Ventures, the
investment arm of CMGI, in December, 1998.

   In May, 1999 MCA acquired Pro Med Co., Inc., a company which distributes
medical equipment and supplies through direct sales and catalogs and which did
business as "Promedix." In May, 1999 MCA changed its name to Promedix.com, Inc.
Promedix is a Delaware corporation, with headquarters in Salt Lake City, Utah.
The Pro Med Co., Inc. business is scheduled to be sold prior to consummation of
the merger.

   On September 21, 1999, Promedix agreed to sell shares of its Series C
preferred stock to Tenet Healthcare Corporation, with a closing scheduled to
occur on December 22, 1999.

 Market Analysis

   The global market for medical products exceeded $140 billion in 1998, with a
projected 6% to 7% annual growth rate. The U.S. accounts for approximately 40%
of the total, or roughly $55 billion, with per capita spending of $209 per
person, according to the Medical & Healthcare Marketplace Guide published by
IDD Enterprises, 1998-1999. Cost containment measures are restraining growth,
but it is expected that technological advances should help offset these
restraints to the growth rate.

   The healthcare industry as a whole is characterized by the consolidation of
providers into integrated delivery networks (IDN) that are increasingly seeking
to lower procurement costs and to provide a broader base of services than
previously existed. Major acute care facilities are becoming consolidators,
whereby they seek to align with or acquire outpatient, long-term care, and
specialized diagnostic facilities to form IDNs. These facilities are
consequently looking for business solutions to meet the expanded product
acquisition needs of the IDNs, and are focused on methods to reduce operations
costs in the member institutions.

   The healthcare industry as a whole has not been subject to the severe
economic cycles that affect many other businesses. Demand for medical products
has remained at a fairly constant level, and the aging of the

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<PAGE>

population should result in sustained demand for the foreseeable future. The
international market is also expanding, and some markets are growing at rates
two to four times that of the U.S. market, according to the Medical &
Healthcare Marketplace Guide published by IDD Enterprises, 1998--1999.

 Market Niche

   The larger market niche in healthcare, called commodity products, consists
of products purchased in high volume from one of five major distributors,
usually in an electronic fashion (EDI, for the most part). These commodity
products account for approximately two-thirds of all healthcare purchases.
Given the efficient EDI purchasing mechanism, entrenched contract pricing
structure, well-established logistics infrastructure, and relatively low
margins for products, Promedix has not entered this market, which is currently
well served by existing large distributors and general purchasing organizations
(GPOs).

   Instead, Promedix focuses on the market for specialty medical products,
which represents approximately one-third of all healthcare purchases and is not
as well served by existing GPOs and distributors. These products are currently
sold by a fragmented group of several thousand manufacturers and distributors,
usually via telephone and fax (less than 1% of purchase transactions are
conducted electronically). Logistics are handled inefficiently, and margins for
these products vary significantly. Examples of specialty products include:

  .  Surgical instruments

  .  Laparoscopic instruments

  .  Blood and IV filters

  .  Vascular access devices

  .  Cardiac stents and catheters

  .  Infusion devices

 Business Model

   Promedix is using a marketplace business model similar to the existing
Chemdex model. Promedix accepts orders from buyers, and transmits drop-ship
orders to its manufacturer partners. Because Promedix's buyers have expressed a
strong desire for aggregated shipments, the company is exploring relationships
with major logistics providers.

   Another aspect of the model includes selling advanced web-based marketing
services to manufacturers wishing to expand their product presentations.

   In addition to deriving revenue from intermediation service fees described
above, Promedix intends to offer a data mining service. Such a service would
generate periodic reports of product sales for each supplier. Suppliers would
purchase these reports from Promedix in order to develop more efficient
marketing strategies. To expedite an otherwise lengthy negotiation process,
Promedix will offer all of it services on a non-exclusive basis; suppliers who
sell through the Specialty Medical Product Exchange will not be prohibited from
selling through alternative mechanisms.

 Sales Strategy

   To attract manufacturers, Promedix has a sales team, consisting of 10 Vendor
Account Managers. To supplement sales, Promedix attends targeted trade shows to
meet with specific vendors. The shows give

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<PAGE>

Promedix the opportunity to sign up new vendors and improve relations with
existing vendor partners. To attract buyers, the Promedix sales effort is
focused on two market segments: acute care and alternate site.

   Promedix's primary targets in acute care are large IDNs. By meeting with
senior management of each IDN, Promedix intends to establish a formal corporate
relationship with the IDNs and then tailor the best program for integrating the
IDN facilities. Once the guidelines and timeframes are established, the
Promedix sales team and territory managers will conduct the introduction and
implementation phase.

   In the non-hospital market (e.g. surgery centers, medical clinics and
veterinary clinics), Promedix is contacting purchasing agents using the
Promedix sales team, and territory managers, and through attendance at trade
shows. Promedix's primary target in this non-hospital market is surgery
centers.

   The sales process is based upon a three-step approach. While each market has
distinct traits, the Promedix sales approach shares the same structure.
Realizing that Promedix is implementing a new technology paradigm into a
traditionally very conservative industry, the company has created a three-
tiered sales program: Executive Selling and Education, Inside Sales, and
Territory Management. Executive Selling and Education begins when the Promedix
sales team approaches large clients such as IDNs in an effort to generate
awareness and interest about the services Promedix offers. Inside Sales occur
once the initial relationship is established. The Promedix sales team will deal
directly with individual account managers at potential customers, such as
hospitals, to explain the opportunities available from Promedix. Territory
Management involves on-site problem solving at clients to fully integrate
systems and familiarize customers with the services Promedix offers.

 Competition

   The specialty medical product marketplace is controlled by specialty
manufacturers and distributors through a largely non-automated network.
Promedix's principal competitors are the larger regional distributors, like
Tri-anim and Primesource Surgical, which represent products in several sub-
specialties. Many manufacturers who sell directly also have rudimentary e-
commerce sites for their own products.

   Indirect competitors of Promedix are large commodity distributors and group
purchasing organizations (GPOs). The largest medical distributor--Allegiance
Healthcare--has released an e-commerce site called ASAP E-Comm, designed to
sell the commodity products that Allegiance represents. Premier, Inc., the
largest group purchasing organization, has released Premier Select, a site
targeted to the physician and long-term care market, that contains only those
products that Premier has contracted with manufacturers to sell.

   Principal Internet competitors are NeoForma and Medibuy, and to a lesser
extent Cimtek Medical and mrn.com, all of which are following much broader
models which attempt to Internet-enable the entire market structure of
healthcare. There are also several E-commerce sites that indirectly compete
with Promedix, including VerticalNet, ProcureNet, and Industry.Net. Specialty
medical products are also sold in limited quantities by smaller Internet
companies, like Surgical911.com, and by consumer-oriented sites, like Medsite.

 Customer and Supplier Relationships

   Promedix currently has relationships with approximately 500 specialty
medical product suppliers, representing over 325,000 individual products.
Promedix has been testing the site in a controlled release since August, 1999,
with five acute care buyers.

 Proprietary Rights

   Promedix relies on a combination of the protections provided under
applicable copyright, trademark and trade secret laws, as well as confidential
procedures and licensing agreements to establish and protect its rights in its
software. The only federally registered intellectual property Promedix owns is
the trademark "Promedix." Promedix intends to license its software to customers
under standard license agreements, although each license will be individually
negotiated and may contain variations.

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<PAGE>

 Government Regulations

   Promedix currently relies on its suppliers to meet the various regulatory
requirements applicable to the sale of its products, including specialty
medical products regulated by the U.S. Food & Drug Administration (FDA). We
have not verified that they have met all regulatory requirements, or that their
compliance is adequate or sufficient to meet all governmental requirements. We
could be subject to significant penalties or fines, or significant civil or
criminal liability, as well as potential negative publicity, if these
requirements have not been fully met by our suppliers or by us directly. We
could also be subjected to these fines and liabilities, as well as product and
revenue loss and recall costs, if the products are improperly manufactured,
used, or otherwise do not perform as expected. The events described above could
have a material adverse impact on our business, revenues, results of
operations, and financial condition.

   The supply and distribution of medical devices for clinical use are subject
to direct regulation by governmental agencies, which includes the U.S. Food &
Drug Administration (FDA) laws and regulations generally applicable to medical
supplies and healthcare businesses, as well as U.S. export controls and import
controls of other countries, including controls on the use and distribution of
some specialty medical products. FDA requirements include reporting deaths,
serious illnesses and serious injuries that are attributed to the medical
devices we distribute, as well as reporting device malfunctions and filing an
annual certification to FDA. We continue to rely on our suppliers to file these
reports, but may have to do so ourselves. Any failure to comply with applicable
sections of the FDA Act could subject the company to civil and/or criminal
liability. Regarding compliance with the various statutory and regulatory
requirements that relate to our involvement in the sale of specialty medical
products, there are, to our knowledge, currently no investigations, inquiries,
citations, fines, or allegations of violations or noncompliance pending by
government agencies or by third parties against us. It is possible that there
may be investigations or allegations in the future. We are currently reviewing
applicable FDA requirements with regard to present and continuing compliance,
particularly concerning various licensing and sales issues. The risk that any
noncompliance may be discovered in the future is currently unknown. As we
expand our product offering, we may be subject to additional government
regulation. Although any potential impact on us for noncompliance cannot be
established, it could have a material adverse impact on our business, financial
condition and results of operations, result in adverse publicity, and could
result in civil or criminal penalties and liabilities.

 Sale of Pro Med Co., Inc.

   Promedix agreed to sell all of the outstanding shares of capital stock of
its wholly-owned subsidiary, Pro Med Co., a Utah corporation, to an unrelated
third party. The purchaser or purchasers may include one or more of Promedix's
stockholders, including William C. Klintworth, Promedix's Chief Executive
Officer. Pro Med Co. is in the business of marketing and distributing medical
equipment and supplies and is referred to herein as the "fulfillment business."
As a result of such sale, Promedix will no longer own or operate the
fulfillment business. See "Sale of Pro Med Co., Inc." on page  .

 Employees

   After giving affect to the planned sale of Promedix's subsidiary, Pro Med
Co., Inc., Promedix expects to have approximately 130 full-time employees,
including 48 in sales, 50 in technology, and 12 in customer service.

 Facilities

   Promedix's principal offices are located in Murray, Utah where Promedix
subleases approximately 14,000 square feet under a lease that expires in
November, 2000.

 Legal Proceedings

   Promedix is not a party to any legal proceedings which, if adversely
decided, would reasonable be expected to have a materially adverse effect on
the financial condition of Promedix.

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<PAGE>

               PROMEDIX.COM, INC. SELECTED FINANCIAL INFORMATION
                     (In thousands, except per share data)

<TABLE>
<CAPTION>
                                                                Nine Months
                                                                   Ended
                                                               September 30,
                                      Year Ended   Year Ended   (unaudited)
                                     December 31, December 31, ---------------
                                         1997         1998      1998    1999
                                     ------------ ------------ ------  -------
                                      (In thousands, except per share data)
<S>                                  <C>          <C>          <C>     <C>
Statements of Operations Data:
Net revenues.......................      $ 197       $   14     $  14  $ 7,876
Operating loss.....................       (135)         (60)      (54)  (6,636)
Income (loss) before extraordinary
 item..............................        141          (60)      (54)  (6,806)
Extraordinary item.................        --            86        86      --
Net income (loss)..................        141           26        32   (6,806)
Basic net income (loss) per share:
  Loss before extraordinary item...     $(0.10)      $(0.02)   $(0.02) $ (1.94)
  Extraordinary item...............     $  --         $0.03    $ 0.03   $  --
  Net income (loss)................     $(0.10)       $0.01    $ 0.01  $ (1.94)
  Weighted average common shares...      1,380        2,696     2,448    3,502
Diluted net income (loss) per share
  Loss before extraordinary items..     $(0.10)      $(0.01)   $(0.02) $ (1.94)
  Extraordinary item...............     $  --        $ 0.01    $ 0.03   $  --
  Net income (loss)................     $(0.10)       $ --     $ 0.01  $ (1.94)
  Weighted average common shares...      1,380        6,693     2,448    3,502
</TABLE>

<TABLE>
<CAPTION>
                                                       December
                                                          31,      September 30,
                                                      ------------     1999
                                                      1997   1998   (unaudited)
                                                      ----  ------ -------------
                                                           (In thousands)
<S>                                                   <C>   <C>    <C>
Balance Sheet Data:
Cash and Cash equivalents............................ $127  $3,002    $  987
Working capital......................................  (24)  3,001      (670)
Total assets.........................................   20   3,035     9,158
Preferred Stock--Series A............................  --    3,002     3,738
Total liabilities and preferred stock................   41   3,033     9,786
Total stockholders' equity (deficit).................  (21)      2      (628)
</TABLE>

                                       81
<PAGE>

                               PROMEDIX.COM, INC.

          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                           AND RESULTS OF OPERATIONS

   The following "Management's Discussion and Analysis of Results of Operations
and Financial Condition" contains forward-looking statements. In some cases,
readers can identify forward-looking statements by terminology such as "may,"
"will," "should," "could," "expects," "plans," "anticipates," "believes,"
"estimates," "predicts," "potential," or "continue." These statements involve
known and unknown risks, uncertainties and other factors that may cause
Promedix's actual results, performance, or achievements to be materially
different from those stated herein. Although management of Promedix believes
the expectations reflected in the forward-looking statements are reasonable,
Promedix cannot guarantee future results, performance, or achievements.

Overview

   Promedix is an Internet-based specialty medical product marketplace that
links buyers and suppliers in a highly fragmented vertical market by providing
a Java-based product research and purchasing system, called the Specialty
Medical Product Exchange. This vertical marketplace, which is in development,
will provide customers the ability to purchase from multiple specialty medical
products suppliers with a single purchase order and offers integration
capability with major legacy systems currently in use by healthcare
institutions.

   Promedix was previously known as MCA HealthPages, Inc. (MCA) which was
incorporated on December 20, 1996. MCA conducted its principal business--
providing Web design and hosting services for specialty medical manufacturing
clients--beginning in January 1997. Promedix terminated the Web design segment
of the business in early 1998 to concentrate on electronic commerce.

   In late 1997, MCA developed what it called "Medical Village," the first e-
commerce site on the Web for the procurement of specialty medical products. It
was a precursor to the Specialty Medical Product Exchange, offering full search
capability of specialty medical manufacturers and the ability to directly
communicate with them to facilitate purchases.

   In mid-1998, MCA began to aggressively seek venture capital funding for
Medical Village. MCA received first-round funding from CMG @Ventures, the
investment arm of CMGI, in December 1998.

   In May 1999, MCA acquired Pro Med Co., Inc., a company that distributes
medical equipment and products through direct sales and catalogs. In May 1999,
MCA changed its name to Promedix.com, Inc. Promedix is a Delaware corporation,
with headquarters in Salt Lake City, Utah.

   On September 21, 1999, Promedix entered into an agreement in which it would
merge into a wholly-owned subsidiary of Chemdex in exchange for shares of
Chemdex's common stock. Pro Med Co. is scheduled to be sold prior to
consummation of the merger.

   On September 21, 1999, Promedix agreed to sell 176,429 shares of its Series
C preferred stock to Tenet Healthcare Corporation with a closing scheduled to
occur on December 22, 1999.

 Specialty Medical Product Exchange

   Promedix does not have any sales from its Specialty Medical Product
Exchange. Promedix's operating activities are related primarily to the design
and development of the Specialty Medical Product Exchange, building the
corporate infrastructure, establishing relationships with suppliers and
customers and raising capital.

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<PAGE>

Promedix has developed its organization by hiring personnel in key areas,
particularly sales, research and development and marketing.

   Promedix has incurred significant losses since inception and, as of
September 30, 1999, has an accumulated deficit of approximately $6.9 million.
Promedix expects its losses to increase in the future and there can be no
assurance that it will ever achieve or sustain profitability. Promedix believes
its success depends on establishing key strategic supplier and customer
relationships, enhancing the features and functionality of the Specialty
Medical Product Exchange, and accelerating market awareness and demand for the
Specialty Medical Product Exchange. Beginning in 1999, Promedix has increased
its level of spending to build its infrastructure and to develop its Specialty
Medical Product Exchange. Promedix intends to continue to invest heavily in
sales, marketing, research and development and administrative activities.
Promedix has limited operating history upon which to base an evaluation of its
business and there can be no assurance that its revenues will increase in
future periods.

   A key element of Promedix's strategy is to market its solution directly to
healthcare organizations, and to succeed it must satisfy the purchasing
departments and the clinical groups who are the users of Promedix's Internet-
based purchasing solution. The time it takes to sell and implement Promedix's
solution is long and Promedix will devote significant sales, marketing and
management resources to the sales process without any assurance that the
customer will use the Specialty Medical Product Exchange. Promedix will
generally be required to provide a significant level of education regarding the
use and benefits or its Internet-based purchasing solution, due in part to the
significant departure from traditional means of commerce and communications
entailed by its adoption and use. The sale and implementation of Promedix's
solution are expected to be subject to delays due to Promedix's customers'
internal budgets and procedures for deploying new technologies within their
networks. These delays may impair Promedix's ability to generate revenue and
could negatively affect Promedix's results of operations. Once an enterprise
customer adopts Promedix's Internet-based purchasing solution, it will take
time for users within the enterprise to become aware of, learn to use and begin
using Promedix's Specialty Medical Product Exchange. The long sales cycle and
the time it takes to begin using Promedix's Internet-based purchasing solution
could negatively affect Promedix's revenue growth, and make it difficult to
predict Promedix's results of operations.

 Fulfillment Operations

   Through the acquisition of Pro Med Co. in May 1999, Promedix generates
revenue from the sale of emergency medical products and equipment under sales
and distribution agreements with various manufacturers. Customers are located
throughout the United States and primarily include ambulance services, fire
departments and governmental facilities.

   On November 9, 1999, Promedix agreed to sell all of the outstanding shares
of capital stock of Pro Med Co., a Utah corporation and wholly-owned subsidiary
of Promedix, to an unrelated third party. The sale will be completed prior to
the closing of the merger. As a result of such sale, Promedix will no longer
own or operate the fulfillment business.

Results of Operations

 Results of Operations for the Nine Months Ended September 30, 1999

   General. In May 1999, Promedix acquired Pro Med Co. and, as a result,
substantially all revenue and expense categories have increased significantly
from 1998 to 1999.

   Revenues. Revenues increased from $14,034 for the nine month period in 1998
to $7,875,993 for the same period in 1999 as a result of the acquisition of Pro
Med Co. Revenues in 1998 consisted of Web site design and hosting services for
specialty medical manufacturers. These services were terminated in early 1998.

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<PAGE>

   Cost of Revenues. The increase in cost of revenues from $1,100 for the nine
month period in 1998 to $5,776,465 for the comparable period in 1999 is due to
the acquisition of Pro Med Co. Cost of revenues consists primarily of product
costs, net of rebates, and freight charges. As a percent of revenues, cost of
revenues was 73% in 1999.

   Sales and Marketing Expense. Sales and marketing expense increased from zero
for the nine months ended September 30, 1998, to $1,574,886 for the same period
in 1999. Of the increase, $1,182,859 relates to the acquisition of Pro Med Co.
while $392,027 relates to development of the Specialty Medical Product
Exchange. Specialty Medical Product Exchange sales and marketing expenses
consist primarily of advertising and promotion in support of the development of
Promedix's marketing strategy, payroll and related expenses for personnel
engaged in supplier relations and enterprise sales activities. Sales and
marketing expenses have increased as Promedix has continued to expand its sales
and marketing efforts. Promedix intends to aggressively expand its supplier and
customer relationships and to expand its brand awareness. Promedix expects
sales and marketing expenses to increase in future periods.

   General and Administrative Expense. General and administrative expenses
increased from $66,498 for the nine months ended September 30, 1998, to
$3,063,818 for the same period in 1999. Of this increase, $643,181 relates to
the acquisition of Pro Med Co., while $2,354,139 relates to the increase in
general infrastructure expenses for developing the Specialty Medical Product
Exchange. General and administrative expenses for Specialty Medical Product
Exchange consist primarily of salaries, fees for professional services and
office expenses. General and administrative expenses have increased primarily
as a result of the addition of executive and administrative personnel, costs of
leasing additional office space to support Promedix's growth, and expenses
related to increased professional service fees. Promedix expects general and
administrative expenses to increase in future periods to support its expanded
operations.

   Research and Development Expense. For the nine month period ended September
30, 1999, research and development costs increased to $118,568 from the same
period in the prior year. Research and development expenses consist of
personnel and other expenses associated with developing software in support of
the Specialty Medical Products Exchange. Promedix's research and development
expenses have increased due to increased staffing and associated costs related
to the design and development of the Specialty Medical Products Exchange.
Promedix believes that its success is dependent on development of the Specialty
Medical Products Exchange. Accordingly, Promedix expects research and
development expenses to increase in future periods.

   Amortization of Deferred Compensation. The amortization of deferred
compensation reflects the compensation expense for the period from the deferred
stock option compensation.

   Amortization of Intangible Assets. The amortization of intangible assets
results from the acquisition of Pro Med Co.

   Interest Income. For the nine month period ended September 30, 1999,
interest income increased $82,047 from the same period in the prior year.
Interest income has been derived primarily from earnings on cash investments.

   Interest Expense. Interest expense in 1999 increased $236,603 due to the
issuance of the promissory notes to acquire Pro Med Co. in May 1999, and due to
Pro Med Co.'s outstanding indebtedness.

   Income Taxes. Promedix incurred operating losses and accordingly did not
record a provision for income taxes for any of the periods presented except for
a state income tax provision for the nine months ended September 30, 1999. At
December 31, 1998, Promedix had net operating loss carryforwards for federal
and state income tax purposes of $112,000. These net operating losses will
expire through 2012 if not

                                       84
<PAGE>

utilized. Certain future changes in Promedix's share ownership, as defined in
the Tax Reform act of 1986 and similar state provisions, may restrict the
utilization of carryforwards. A valuation allowance has been recorded for the
entire deferred tax asset as a result of uncertainties regarding the
realization of the assets due to Promedix's lack of earnings history.

 Results of Operations for the Year Ended December 31, 1998 compared with
 December 31, 1997

   Revenues. Revenues decreased from $197,249 in 1997 to $14,034 in 1998 due to
the termination in early 1998 of the Web site design and hosting services
provided for specialty medical manufacturers. Revenues for both periods
included fees generated for initial design, hosting and renewal services.

   Cost of Revenues. Cost of revenues decreased from $55,542 in 1997 to $1,100
in 1998 also due to the termination of Web site design and hosting services
noted above. Cost of revenues included outside hosting service fees and product
costs.

   General and Administrative Expenses. General and administrative expenses
decreased from $246,306 in 1997 to $73,236 in 1998, due to the termination of
operations. General and administrative expenses included primarily expenses for
personnel, consultants, office rent and travel. Certain general and
administrative expenses continued through 1998 for activities relating to
developing and financing the concept of the Medical Village.

   Extraordinary Item. The extraordinary item in 1998 is related to the
forgiveness of indebtedness from a related party which had made advances to
Promedix to assist Promedix in funding its operations.

Liquidity and Capital Resources

   Promedix has funded its e-commerce operations primarily through the sale of
its preferred and common securities, through which it has raised net proceeds
of approximately $3.1 million through September 30, 1999. Promedix has also
obtained equipment operating leases. Through Pro Med Co., the fulfillment
operations have utilized a $2.5 million line of credit with a bank for working
capital purposes.

   As of September 30, 1999, Promedix's principal sources of liquidity included
(i) $987,367 in cash and cash equivalents, (ii) a $10 million line of credit
with Chemdex and (iii) the Pro Med Co. $2.5 million working capital facility,
of which $1,531,692 was funded as of September 30, 1999. The $10 million
Chemdex credit arrangement provides for ratable monthly advances for working
capital purchases through March 1, 2000, bears interest at 9%, is secured by
substantially all of Promedix's assets and is due by December 31, 2000, or
earlier under certain conditions. The Pro Med Co. bank credit facility allows
for borrowings up to $2.5 million depending upon borrowing base availability,
bears interest at the bank's prime rate plus 0.25%, is secured by substantially
all of Pro Med Co.'s assets and is due in July 2000.

   Net cash used in operating activities totaled $1,439,656 in the first nine
months of 1999. The net cash used in the operating activities in the first nine
months of 1999 was primarily due to net losses, which were partially offset by
non-cash charges of depreciation and amortization of deferred compensation,
amortization of intangible assets, and increases in accounts payable and
accrued expenses. Net cash used in investing activities was $661,828 in the
first nine months of 1999, primarily for the purchase of property and
equipment, and the acquisition of Pro Med Co. partially offset by the sale of
assets. Net cash from financing activities resulted primarily from the
borrowings on the line of credit and the sale of preferred and common stock. In
addition, Promedix has received a funding commitment from an investor to fund
operational requirements to the extent necessary for the next calendar year.

   Promedix currently anticipates that the current cash and cash equivalents,
Chemdex credit line, and Pro Med Co. bank line will be sufficient to meet
Promedix's cash needs for working capital and capital expenditures through the
completion of the merger.

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<PAGE>

Management Information Systems

 Year 2000 Compliance

   Many currently installed computer systems and software products are unable
to distinguish year 2000 dates. This situation could result in system failures
or miscalculations causing disruptions in the operations of any business. As a
result, many companies' software and computer systems may need to be upgraded
or replaced to comply with the year 2000 requirements. Promedix's ability to
operate is dependent upon delivery of accurate electronic information via the
Internet. To the extent year 2000 issues result in the long-term inoperability
of the Internet or the Specialty Medical Products Exchange business, results of
operations and financial condition could be seriously harmed.

   Promedix completed an assessment of its information technology system for
the year 2000 problem in June 1999. Promedix has not replaced any of its
systems based on the results of its assessment. However, Promedix has made
modifications to some systems based on its assessment of the year 2000
problems.

Quantitative and Qualitative Disclosures About Market Risk

   Promedix's sales from inception to date have been made to U.S. customers
and, as a result, it has not had any exposure to factors such as changes in
foreign currency exchange rates or weak economic conditions in foreign markets.
However, in future periods, Promedix expects to sell in foreign markets. As
Promedix's sales are made in U.S. dollars, a strengthening of the U.S. dollar
could make Promedix's products less competitive in foreign markets. At
September 30, 1999, Promedix's cash and cash equivalents consisted primarily of
money market funds and commercial paper held by large institutions in the U.S.

Factors Affecting Future Results

   The following discussion should be read in conjunction with the financial
statements and notes thereto included herein.

   Promedix desires to take advantage of the "safe harbor" provision of the
Private Securities Litigation Reform Act of 1995. Specifically, Promedix wishes
to alert readers that, except for the historical information contained in this
Management's Discussion and Analysis of Financial Condition and Results of
Operations, the matters discussed herein are forward-looking statements that
are subject to certain risks and uncertainties that could cause the actual
results to differ materially from those projected. Factors that could cause
actual results to differ materially include, but are not limited to, outcomes
in litigation proceedings, market demand for Promedix's products, the timely
development and market acceptance of new products and surgical procedures, the
impact of performance of Promedix's distributors and direct sales force,
Promedix's ability to further expand into international markets, public policy
relating to healthcare reform in the United States and other countries,
approval of its products by government agencies such as the United States Food
and Drug Administration, and other risks detailed below. Promedix assumes no
obligation to update any forward-looking statement contained herein. The
factors in the future listed under "Factors Affecting Future Results," as well
as other factors, have in the past affected, and could in the future affect,
Promedix's actual results and could cause Promedix's results for future periods
to differ materially form those expressed in any forward-looking statements.

                                       86
<PAGE>

                              PROMEDIX MANAGEMENT

   Mr. William C. Klintworth is the only executive officer or director of
Promedix who will serve as an executive officer or director of Chemdex after
the merger. Information concerning Mr. Klintworth is provided below:

Biographical Information

   Mr. Klintworth is the Chief Executive Officer and President of Promedix and
chairman of its board of directors. Mr. Klintworth has been Chairman and
director of Promedix since its inception in 1996 and its Chief Executive
Officer since January 1999. Prior to that, he was the founder and director of
HTD Corporation, a national medical specialty distribution company. From 1974
to 1995, Mr. Klintworth served as the Chief Executive Officer for numerous
medical manufacturers, including Alpha ProTech, a manufacturer of non-woven
surgical products, and Carapace, Inc., a manufacturing firm making orthopedic
cast materials and supports. Mr. Klintworth holds a Bachelor of Science degree
in Business Administration from Southern Methodist University. Mr. Klintworth
is also a director of Pro Med Co., Inc., a subsidiary of Promedix that will be
sold prior to the merger. See "Sale of the Pro Med Co., Inc." page 80.

Compensation

   A summary compensation table, setting forth Mr. Klintworth's compensation
from Promedix for the last completed fiscal year, is stated below:

                           Summary Compensation Table

<TABLE>
<CAPTION>
                                                         Annual Compensation
                                                     ---------------------------
Name and Position                                    Year Salary  Bonus Other(1)
- -----------------                                    ---- ------- ----- --------
<S>                                                  <C>  <C>     <C>   <C>
William C. Klintworth,.............................. 1999 100,400    0   1,088
 President and Chief Executive Officer
</TABLE>
- --------
(1) Employer 401(k) contributions through December 31, 1999.

                      PROMEDIX RELATED PARTY TRANSACTIONS

   Mr. Klintworth is employed by Promedix as Chief Executive Officer at an
annual salary of $150,000. Mr. Klintworth's employment is at will and is not
subject to any formal employment agreement.

   Promedix has agreed to sell all of the outstanding shares of capital stock
of its wholly-owned subsidiary, Pro Med Co., a Utah Corporation, to Equus
Capital. The purchaser or purchasers may include one or more of Promedix's
stockholders, including William C. Klintworth, Promedix's Chief Executive
Officer.

   CMGI and/or its affiliates beneficially own 2,728,357shares of Chemdex
common stock, representing approximately 8.3% of the outstanding Chemdex common
stock, and 3,996,800 shares of Promedix preferred stock, representing
approximately 42.3% of the outstanding Promedix capital stock. Following
consummation of the merger, CMGI and its affiliates will beneficially own
approximately 18.9% of the outstanding Chemdex common stock. Jonathan D.
Callaghan is a general partner of CMG@Ventures, a CMGI affiliate, and is a
member of both the Chemdex board of directors and Promedix board of directors.

                                       87
<PAGE>

                       PRINCIPAL STOCKHOLDERS OF PROMEDIX

   The following table provides information regarding the beneficial ownership
of Promedix's capital stock as of September 30, 1999 by:

  . each person who is known by Promedix to own beneficially 5% or more of
    any class of Promedix's capital stock;

  . each of Promedix's directors; and

  . Promedix's chief executive officer and each of the other four most highly
    compensated executive officers.

   The following tables set forth as of September 30, 1999, certain information
with respect to the beneficial ownership of the capital stock of Promedix. The
total capitalization calculation does not include ungranted stock options,
which total 572,239.

<TABLE>
<CAPTION>
                                          Amount and                  Proforma
                                          Nature of                 Ownership of
Name and Address of                       Beneficial Percent of all   Chemdex
Beneficial Owner          Type of Stock   Ownership   Class/Series     Common
- -------------------      ---------------- ---------- -------------- ------------
<S>                      <C>              <C>        <C>            <C>
@Ventures III, LP......  Series A         3,121,500       33.0%         7.9%
 Attn: Peter Mills,
 Jonathan Callaghan      Preferred
 3000 Alpine Road
 Menlo Park, CA 94025

CMG@Ventures III, LP...  Series A           875,300        9.3%         2.2%
 Attn: Peter Mills,
 Jonathan Callaghan      Preferred
 3000 Alpine Road
 Menlo Park, CA 94025

William C. Klintworth..  Common           1,907,347       20.2%         4.9%
 488 E. Winchester,
 Suite 200
 Salt Lake City, UT
 84107

E.L. Klintworth
 Revocable Trust.......  Common              67,320          *          0.2%
 2660 S. Birmingham
 Place
 Tulsa, OK 74114
 (related to William C.
 Klintworth)

Bradford C. Bond.......  Common             600,100        6.3%         1.5%
 25 Westwood Road
 Park City, UT 84098

John B. Benear, II.....  Common             456,100        4.8%         1.2%

Ed Kuklenski...........  Common              75,000        0.9%         0.2%
Child Health Investment
 Corp..................  Common              98,520        1.0%         0.2%
Barrie D. Brewer.......  Series B-2         140,579        1.5%         0.4%
                         Preferred
                         Series B-1         166,667        1.8%         0.4%
                         Preferred
                         Options             41,667        0.4%         0.1%
J. Barrie Keiser ......  Unvested Options       --         -- %         -- %
Thomas J. Sherry.......  Unvested Options       --         -- %         -- %

All executive officers
 and directors as a
 group (  persons).....
</TABLE>

                                       88
<PAGE>

                           INFORMATION ABOUT CHEMDEX

Chemdex's Business

 Overview

   Chemdex is a leading provider of e-commerce solutions to the highly
fragmented life sciences industry. We enable life sciences enterprises,
researchers and suppliers to efficiently buy and sell research products through
the Chemdex Marketplace, a secure, Internet-based purchasing solution. The
Chemdex Marketplace utilizes an advanced search engine and software to allow
users to easily identify, locate and purchase life sciences research products.
We believe the Chemdex Marketplace and purchasing solution provide significant
benefits to enterprises, researchers and suppliers.

 Industry Background

  Growth of Business-to-Business Commerce on the Internet

   The Internet has emerged as the fastest growing communications medium in
history and is dramatically changing how businesses and individuals communicate
and share information. International Data Corporation estimates that the number
of Internet users will grow from 97 million at the end of 1998 to 320 million
by 2002, though Chemdex may not benefit from this growth. The Internet has
created new opportunities for conducting commerce, such as business-to-consumer
and person-to-person e-commerce. Recently, the widespread adoption of intranets
and the acceptance of the Internet as a business communications platform has
created a foundation for business-to-business e-commerce that offers the
potential for organizations to streamline complex processes, lower costs and
improve productivity. Internet-based business-to-business e-commerce is poised
for rapid growth and is expected to represent a significantly larger
opportunity than business-to-consumer or person-to-person e-commerce. According
to Forrester Research, business-to-business e-commerce is expected to grow from
$43 billion in 1998 to $1.3 trillion in 2003, accounting for more than 90% of
the dollar value of e-commerce in the United States by 2003, though Chemdex may
not benefit from this growth.

   The dynamics of business-to-business e-commerce relationships differ
significantly from those of other e-commerce relationships. Business-to-
business e-commerce solutions frequently automate or otherwise impact workflows
or processes that are fundamental to a business's operations by replacing
various paper-based transactions with electronic communications. In addition,
business-to-business e-commerce solutions must often be integrated with an
enterprise's existing information systems, a process that can be complex, time-
consuming and expensive. Finally, personnel throughout the enterprise must be
trained to use the solution. Consequently, selection and implementation of a
business-to-business e-commerce solution represents a significant commitment by
the enterprise, and the costs of switching solutions are high. In addition,
because business transactions are typically recurring and non-discretionary,
the average order size and lifetime value of a business-to-business e-commerce
customer is generally greater than that of a business-to-consumer e-commerce
customer.

   Business-to-business e-commerce solutions that offer improved efficiency
through the automation of business processes and workflows are being targeted
toward a variety of industries. These solutions are likely to be most readily
accepted by industries characterized by a large number of buyers and sellers, a
high degree of fragmentation among buyers, sellers or both, significant
dependence on information exchange, large transaction volume and user
acceptance of the Internet.

  The Life Sciences Research Products Market

   The life sciences research products market is large and growing, with a
myriad customers and suppliers. According to the Laboratory Products
Association, the North American life sciences research products market

                                       89
<PAGE>

was estimated to be approximately $9.4 billion in 1998. Outside of North
America, the life sciences research products market is concentrated in Europe
and Japan. The growth in the life sciences research products market is driven
by increasing research and development expenditures by pharmaceutical and
biotechnology companies, as well as an increase in the level of research
funding available for grant by the National Institutes of Health, similar
international government agencies and private foundations. Research and
development budgets have been increasing as new discovery tools, such as
genomics, combinatorial chemistry and high-throughput screening, are developed
and utilized. These new technologies allow researchers to experiment with
thousands of chemical compounds simultaneously, which requires extensive use of
reagents and other life sciences research products.

   The life sciences research products market is highly fragmented. There are
over 5,000 suppliers offering more than one million products, many of which are
highly specialized. Life sciences research products include reagents, chemical
compounds, specialty chemicals, consumables, research instruments and other
equipment. The primary purchasers and users of life sciences research products
are research scientists working in pharmaceutical and biotechnology companies,
and academic and research institutions.

  Limitations of Traditional Purchasing Methods for Life Sciences Research
  Products

   Traditional purchasing methods in the life sciences industry are
inefficient, costly and time-consuming for both the researcher and the
enterprise. Product orders are traditionally handled through an internal,
paper-based purchasing process that requires manual preparation of a purchase
order, written approval by the researcher's purchasing manager and manual order
tracking, billing and reporting across multiple departments within the
enterprise. Researchers, or their purchasing agents, place orders by telephone,
fax or e-mail and typically must place orders with multiple suppliers to obtain
all products related to a single research experiment. Additionally, the paper-
based orders are costly for purchasers and suppliers to track and bill, and the
decentralized order process does not facilitate data collection, which is
required to take full advantage of volume discounts or other economies of
scale. In addition, given the specialized and complex nature of life sciences
research products, the researchers have specific and unique knowledge regarding
product selection. Therefore, it is difficult to integrate these purchases with
the enterprise's purchasing policies and business rules.

   The fragmentation of the life sciences supplier base also creates
inefficiencies for researchers. Since the researcher is often searching for a
specific product to meet the parameters of a research experiment, the current
paper-based purchasing process is complex, cumbersome and time-consuming. For
example, a life sciences researcher studying intracellular communications
related to cancer cells may need to purchase select antibodies for use in a
research experiment. There are numerous suppliers of antibodies, and product
specificity, reactivity, purity and other characteristics vary among suppliers.
Researchers may spend several hours examining multiple paper product catalogs
and other information from different suppliers to identify the most appropriate
product.

   Traditional purchasing methods also present a number of challenges to
suppliers trying to reach life sciences researchers with product information.
Due to the high cost of printing and distributing paper catalogs, suppliers
cannot cost-effectively manage frequent updates and distribution of time-
sensitive information. In addition, individual researchers frequently move from
enterprise to enterprise, making it difficult for suppliers to maintain contact
with them. While some suppliers have developed Internet websites to communicate
with individual researchers, few have invested the significant time and money
required to establish an effective e-commerce channel with their customer base.
Most suppliers, often very small in size, have limited resources available to
support the growing challenge of marketing and selling to the fragmented,
worldwide life sciences research products market.

  Opportunity for Business-to-Business E-commerce Solution

   Recognizing the limitations of traditional purchasing methods, several large
pharmaceutical and biotechnology companies have developed automated purchasing
systems. These systems attempt to streamline

                                       90
<PAGE>

the purchasing process and leverage purchasing volumes, but often have
limitations. These solutions may only offer access to the products of a limited
number of suppliers and may not be scalable. In addition, enterprises incur
significant costs developing internal solutions, integrating them with other
enterprise systems and maintaining their compliance with the enterprise's
business rules and purchasing policies.

   Despite efforts by these enterprises, the fragmentation and complexities of
the life sciences industry and the current paper-based purchasing process
create the need for a business-to-business e-commerce solution that seamlessly
links suppliers and purchasers of research products. To effectively address the
needs of the life sciences enterprise, a solution must be cost-effective,
easily implemented and maintained, enable the enterprise to enforce its
particular purchasing policies and business rules, enable the collection of
data to maximize volume purchase discounts and interface to multiple suppliers.
To effectively address the needs of the researcher, a solution must be easy to
use and provide comprehensive product selection, in-depth product information,
specialized search capabilities and an efficient order and order-tracking
mechanism. To effectively address the needs of customers and suppliers, it is
important that the solution offer a neutral and fair marketplace with full
catalog descriptions of products and retail product pricing information. Such
information must also be fairly and accurately presented to researchers. In
addition, the solution should offer suppliers an opportunity for incremental
sales, the ability to offer customer-specific pricing and an opportunity to
leverage any existing electronic catalogs that may have been implemented by the
supplier.

 The Chemdex Solution

   Chemdex is a leading provider of e-commerce solutions to the life sciences
research products market. The Chemdex Marketplace is a secure, Internet-based
purchasing solution that enables life sciences enterprises, researchers and
suppliers to efficiently buy and sell life sciences research products. The
Chemdex Marketplace utilizes a database of approximately 750,000 life sciences
research products, advanced search engines and transaction software that enable
users to easily identify, locate and purchase the products they need. We also
provide applications that enable our customers and suppliers to interface with
the Chemdex Marketplace to automate their transactions. In addition to the
Chemdex Marketplace, we provide professional and implementation services to
enable our customers to take full advantage of the capabilities of the Chemdex
Marketplace.

  Benefits to the Enterprise

   Chemdex's purchasing solution enables enterprises to integrate their
business rules and processes, and negotiated supplier pricing with the Chemdex
Marketplace. We also provide enterprises the option of tailoring our solution
to meet their needs. Our purchasing solution requires minimal investment of
time and capital by our enterprise customers to install, maintain and use. Our
solution automates, consolidates and monitors the approval and invoicing
process as well as the order placement and delivery information for the
enterprise. In addition to reducing the cost of purchasing, our solution allows
our enterprise customers to enforce their particular business rules and
aggregate purchases to obtain volume discounts and other economies of scale.
The Chemdex Marketplace resides entirely on our servers, is accessible by
standard browsers and requires minimal software installation or integration at
the customer site.

  Benefits to the Researcher

   Researchers, research assistants and other users within enterprises benefit
from the Chemdex Marketplace because it offers them convenient and easy one-
stop shopping. A researcher can use our advanced search engine to identify and
locate products from a broad product database and can use our automated
ordering and approval process to purchase products. For example, our solution
allows a researcher to personalize a list of product favorites to facilitate
product selection and recurring orders. The Chemdex Marketplace offers other
advantages over the traditional paper catalog alternative, including the online
ability to compare various products from a single or multiple suppliers and
track the progress of an order. These features result in significant time
savings for the researcher.

                                       91
<PAGE>

  Benefits to the Supplier

   We offer suppliers a cost-effective opportunity to reach more customers and
sell more products by establishing or enhancing their Internet presence and
providing links to existing online or electronic catalogs. The Chemdex
Marketplace also offers suppliers the capability to implement customer-specific
pricing, update product information and introduce new products without being
limited by specific catalog publication cycles. In many cases, the Chemdex
Marketplace will appeal to suppliers as being less costly than traditional
distribution or representation arrangements because, among other factors, our
purchasing discounts may be less than those of traditional distributors. We
plan to provide tools to our suppliers that enable the online update and
modification of their product databases hosted on our servers, or to integrate
the Chemdex Marketplace directly with their systems. The Chemdex Marketplace is
neutral in that its search capability identifies products that meet the
researchers' search criteria, and provides an unbiased comparison of product
characteristics and pricing to allow the researcher to make a reasoned choice
based upon the information provided by suppliers.

 The Chemdex Strategy

   Our objective is to expand upon our position as a leading e-commerce
solution for the life sciences industry. Our strategy to achieve this objective
includes the following key elements:

   Capitalize on Market Position and Build Customer Brand Recognition. We
intend to capitalize on the fact that we are one of the first companies to
offer an e-commerce solution to the life sciences research products market by
offering the most comprehensive e-commerce solution to the life sciences
research products market. We also intend to pursue strategic relationships with
industry leaders, such as those we have established with VWR Scientific
Products Corporation (VWR) and the Biotechnology Industry Organization (BIO),
to accelerate market awareness and demand for our e-commerce solution. We
intend to leverage our strategic relationship with VWR to gain entry into and
establish relationships with their enterprise customers and life sciences
research product suppliers. We also intend to pursue an aggressive brand
development strategy through targeted advertising and promotions, press
coverage and participation in trade associations and industry events.

   Expand Product Offering and Increase Adoption of the Chemdex Marketplace. We
believe our breadth of products and purchasing solution provide us with an
essential foundation for a comprehensive e-commerce solution for the life
sciences industry. We currently offer approximately 750,000 products from
approximately 177 suppliers. We have agreements with an additional 142
suppliers that provide us access to approximately 310,000 additional products
that we plan to add to the Chemdex Marketplace. We intend to advance our market
leadership by continuing to expand the selection of life sciences research
products offered through the Chemdex Marketplace. A growing number of suppliers
and products in the Chemdex Marketplace will potentially draw more enterprise
customers and accelerate adoption by researchers. As the Chemdex Marketplace
attracts a critical mass of enterprise customers and researchers, we believe
the buying power of these customers will attract additional suppliers to our
marketplace. We also believe this growth cycle will help create a network
effect, where the value to each in the network increases with the addition of
each new participant, increasing the overall value of the Chemdex Marketplace.

   Increase Usage of Chemdex Marketplace and Increase Our Productivity. We
intend to aggressively increase the base of enterprise customers using the
Chemdex Marketplace, and drive rapid adoption within current and future
enterprise customers. Our hosted, Internet-based purchasing solution can be
quickly and easily installed at the enterprise, reducing the initial commitment
of time and capital for new enterprises adopting our solution. To encourage
implementation throughout the enterprise, we charge minimal initial fees, and
in some cases waive initial fees if customers achieve minimum purchase volumes.
Additionally, we will continue to educate users within our existing and future
enterprise customers about the benefits of our solution and provide training on
its use, thereby accelerating adoption. The cost of processing individual
transactions will drop as the volume of transactions processed by the Chemdex
Marketplace continues to grow, and through increased volumes and further
automation of our solution, we will strive to increase productivity across our
business.

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<PAGE>

   Maintain Technological Leadership. We intend to continue to improve our
technology to meet the evolving needs of our customers. We will continue to
expend substantial efforts to develop, purchase or license technological
advancements to our purchasing solution to enhance its reliability,
functionality and ease of integration with existing or newly developed
enterprise resource planning applications and other purchasing systems. We
intend to further automate the collection of product information from key
suppliers, which will enable timely updates of product information, as well as
inventory availability. We also intend to improve our customer- and supplier-
specific pricing flexibility and to enable purchasing in multiple foreign
currencies.

   Expand Internationally. We believe the international scope of the Internet,
the global reach of many of our customers and the worldwide demand for life
sciences research products present opportunities to expand our Chemdex
Marketplace internationally. The non-U.S. life sciences research products
market is highly concentrated in Europe and Japan, and U.S. suppliers have a
substantial presence in these markets. We plan to leverage our technology,
expertise and existing supplier relationships to expand our Chemdex Marketplace
to Europe and Asia.

 The Chemdex Marketplace

   Our Chemdex Marketplace consists of a broad database of approximately
750,000 life sciences research products and advanced search engine and
transaction software that enable users to easily identify, locate and purchase
the products they need. We also provide applications that enable our customers
and suppliers to interface and automate the information exchange with the
Chemdex Marketplace. In addition to our Chemdex Marketplace and Internet-based
applications, we provide professional and implementation services to enable our
customers to take full advantage of the capabilities of the Chemdex
Marketplace. We believe that our business model, which is based on negotiated
price discounts from our suppliers rather than transaction fees payable by the
customer, will further drive usage of the Chemdex Marketplace. In addition, our
customer support and sales group helps customers understand both the business
and technical benefits of the Chemdex Marketplace and provides one-on-one
education and training to increase user adoption.

   The following chart summarizes the key services supported by the Chemdex
Marketplace and the features of these services.

<TABLE>
<CAPTION>
                       Services Supported                            Chemdex Features
- -----------------------------------------------------------------------------------------------------
<S>         <C>                                       <C>
 Enterprise . Purchasing system management            . Interface to existing enterprise network and
            . Approval and purchase of life sciences   ERP software
             research products                        . Automated order approval process
                                                      . Summary invoicing and reporting
                                                      . Enforcement of business rules
                                                      . Customized supplier pricing
                                                      . Comparative price/product shopping
- -----------------------------------------------------------------------------------------------------
 Researcher . Identification, comparison and purchase . One-stop shopping
             of life sciences research products       . Search engine to identify, locate and compare
                                                       products
                                                      . Current, detailed product information
                                                      . Automated order submission and status
                                                      . Recurring order form
- -----------------------------------------------------------------------------------------------------
 Supplier   . Sale of life sciences research products . Support integration with supplier sales
                                                       order flow
                                                      . Automated order submission and tracking
                                                      . Automated process for updating and adding
                                                       product/price information
                                                      . Customer support services
</TABLE>



                                       93
<PAGE>

   How it works for the enterprise. The enterprise customer interface with the
Chemdex Marketplace varies based upon the customer's existing purchasing
system. Our applications and services can be implemented as a stand-alone
solution, or can be integrated with existing systems or other commercially
available purchasing solutions. Our applications are designed to be easily
customized to match the workflow requirements and business rules of the
enterprise. We also provide access to the Chemdex Marketplace through our web
site. In most cases, the most important impact of our solution is paperless
automation of the purchasing approval process. Purchasing limits are most often
applied on an individual researcher or project basis, and the Chemdex
Marketplace interfaces with the enterprise's system to ensure compliance with
defined limits. Our solution can be integrated with enterprise financial
accounting systems to further automate specific product purchase information.
The enterprise's information technology group has few support requirements
beyond the initial installation, since the Chemdex Marketplace is entirely
hosted on our client servers with all recurring product upgrades managed and
installed by us.

   How it works for the researcher. The researcher most often interfaces with
the Chemdex Marketplace to order specific products for research experiments. In
many cases, the researcher needs the same items on a regular basis and our
solution allows a researcher to personalize a list of "favorites" to facilitate
product selection and recurring orders. The Chemdex Marketplace also provides
robust product search capabilities that help researchers identify new products
needed to meet the specific characteristics required for an experiment.
Researchers have password access to the system, and can easily process their
recurring orders, as well as orders for new products. The system allows the
researcher to identify the incremental shipping costs for expedited processing,
and provides for automated paperless processing of an order once the product
selection is complete. The researcher is also able to track the status of
individual orders within the system, reducing the time required to communicate
with purchasing personnel or suppliers.

   How it works for the supplier. Electronic versions of product catalogs are
provided to us in a variety of file formats. These files are converted to
searchable data which is loaded into the Chemdex Marketplace using a number of
sophisticated product loading algorithms. Our content engineering staff then
reviews the data as loaded in the Chemdex Marketplace to ensure proper
classification for purposes of product searches. The ability to process large
volumes of complex catalog information is an important core competency which
allows us to afford maximum flexibility to our suppliers in loading data and
updating information. We also provide suppliers the ability to readily update
their product information to include revised pricing, new product introductions
or additional product details of interest to the customers. We send product
order information to suppliers in a number of electronic media forms, including
electronic data interchange, e-mail, HTML or flat file, to maximize automation
and integration with existing supplier software systems.

   Future Services. Chemdex anticipates that aggregated product purchasing and
sales information will ultimately be valuable to both suppliers and customers.
After accumulating significant historical data regarding buying patterns, we
intend to make non-confidential, aggregated information available to both
suppliers and customers as an additional service.

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<PAGE>

 Our Customers

   Our target customers are pharmaceutical and biotechnology companies and
academic and research institutions. As of September 30, 1999, we have entered
into agreements to provide our purchasing solution to 73 enterprise customers
and have over 16,550 registered users. Sales to researchers at our top four
enterprise customers accounted for approximately 32%, 16%, 15% and 11%,
respectively, of our total revenue for the quarter ended September 30, 1999.

   The following is a list of our enterprise customers that had used the
Chemdex Marketplace to purchase life sciences research products as of September
30, 1999:

<TABLE>
       <S>                              <C>
       Acorda Therapeutics              Inspire Pharmaceuticals
       AlphaOne Pharmaceuticals         Intronn, Inc.
       Arbor Vita                       Kimeragen, Inc.
       Arcaris                          Maxygen
       Ares Advanced Technology         MDS Panlabs
       Array BioPharma                  Medlmmune, Inc.
       AstraZeneca                      Mergen Ltd.
       Avant Immunotherapies, Inc.      Metra Biosystems
       Biogen                           Mitokor
       Bion, Inc.                       Nanogen
       Bristol-Myers Squibb Company     NeoRx
       Calydon                          Neuralstem Biopharmaceuticals
       Ceptyr                           Ontogeny, Inc.
       ChemoCentryx                     Onyx
       Consensus                        Osiris Therapeutics, Inc.
       Corixa Corporation               Paradigm Genetics
       CV Therapeutics                  Phenogenex
       Cytoclonal Pharmaceutics         Phyton, Inc.
       Cytologix                        Protein Delivery
       Depo Med                         Protein Sciences
       Elan Pharmaceuticals             Raven Biotechnologies
       EntreMed, Inc.                   Research Genetics
       Eos                              Rhone Poulenc Rorer
       Epicyte Pharmaceutical           Roche Bioscience
       EPIX Medical                     Scios
       Exelixis Pharmaceuticals         Scytek Laboratories
       Genetech                         SelectiveGenetics
       Genesoft                         Signal Pharmaceuticals
       Genome Therapeutics Corporation  SmithKline Beecham
       Genpharm                         Synpac
       Harvard University               Telik
       Hemasure, Inc.                   University of California San Francisco
       Hope Heart Institute             University of Illinois
       Immune Complex Corp.             Variagenics
       Immuno Gen, Inc.                 Vaxgen
       Impax Pharmaceuticals, Inc.      Zymogenetics
</TABLE>

   We also sell life sciences research products to registered users who are not
affiliated with our enterprise customers through our web site at
www.chemdex.com. Because of the nature of some of the products we sell, we are
taking steps to register unaffiliated users to our web site to ensure that they
are associated with pharmaceutical or biotechnology companies, or academic or
research institutions.

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<PAGE>

   Although we intend to increase our sales and marketing efforts, we expect
that we will continue to generate a significant portion of our revenue from a
limited number of customers for the foreseeable future. If we do not increase
the number of our customers, or if we lose any of our current customers or do
not generate as much revenue from them as we expect, our business would be
significantly harmed.

 Our Suppliers

   We believe the value and benefit to our customers of our purchasing solution
is directly related to the breadth and depth of life sciences research products
offered through our Chemdex Marketplace. We currently offer approximately
750,000 products from approximately 177 suppliers. We have agreements with an
additional 142 suppliers for approximately 310,000 additional products which we
plan to add to our Chemdex Marketplace. The following is a list of our most
significant product suppliers who have entered into agreements as of
September 30, 1999:

<TABLE>
       <S>                         <C>
       Beckman Coulter             BioWhittaker/FMC
       Calbiochem                  CHEMICON International
       Clontech Laboratories       Cole-Parmer
       Forma Scientific            Greiner America, Inc.
       Hitachi Genetic Systems     HyClone
       Incyte Pharmaceuticals      Molecular Probes
       PharMingen                  Pierce Chemicals
       Quidel Corporation          United States Biologicals
       Amersham Pharmicia Biotech
</TABLE>

   We currently have twelve employees who are responsible for maintaining
existing relationships and establishing new relationships with suppliers.

 Strategic Relationship with VWR

   In April 1999, we entered into a strategic relationship agreement with VWR
Scientific Products Corporation to jointly market VWR laboratory products using
the Chemdex Marketplace. VWR is one of the laboratory supply industry's largest
distributors. The agreement gives us the right to offer approximately 350,000
VWR-distributed products to our customers through the Chemdex Marketplace. VWR
and Chemdex are jointly developing a hosted, co-branded Internet purchasing
solution for VWR's existing and future customers that will provide access to
three categories of products:

  . products distributed by VWR (VWR core products),

  .products distributed by Chemdex (Chemdex core products), and

  . products that are not distributed by either VWR or Chemdex but are
    purchased from third parties (third- party products).

   With respect to sales of VWR core products, we act as an intermediary and
forward orders received through the Chemdex Marketplace to VWR for fulfillment
and customer service. We receive no fee for orders for VWR core products from
VWR's 40 largest customers and we receive a minimal fee for all other orders
for VWR core products forwarded to VWR. We are responsible for fulfillment and
customer service for all Chemdex core products and orders for third-party
products received from VWR customers through the Chemdex Marketplace. Under the
terms of the agreement, VWR provides support for the purchase of third- party
products in return for a fee which approximates VWR's costs incurred.

   VWR and Chemdex jointly market VWR core products and Chemdex core products
to VWR's existing and new customers and jointly solicit several key existing
VWR suppliers to distribute, market and sell their products through the Chemdex
Marketplace. We believe the VWR strategic relationship will continue to

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enhance and broaden the Chemdex Marketplace, and the availability of third-
party products will enable us to offer complete fulfillment capability to
current and future VWR customers through the co-branded Chemdex Marketplace. We
believe the VWR strategic relationship will accelerate adoption of the Chemdex
Marketplace by VWR customers, which include major U.S. pharmaceutical and
biotechnology companies, and will enable us to establish relationships with
additional key suppliers and customers.

   As part of the strategic relationship, Jerrold Harris, the President and
Chief Executive Officer of VWR, joined our board. In addition, VWR received
2,538,405 shares of our common stock. VWR is subject to contractual limits on
their percentage ownership of our stock, except in connection with the
acquisition of our stock by specified companies.

 Relationship with BIO

   The Biotechnology Industry Organization (BIO) selected us as its preferred
supplier of electronic commerce solutions. As a result, we entered into a five-
year, exclusive joint marketing agreement with BIO. We believe this agreement
will significantly facilitate the selection and adoption of the Chemdex
solution by BIO's members and provide us with a significant competitive
advantage. Under the agreement, BIO agreed to endorse us as the preferred
provider of electronic commerce purchasing solutions to the biotechnology
industry and engage with us in joint marketing activities, including
endorsement of Chemdex through BIO-sponsored speaking engagements, in BIO
publications and direct marketing materials, at BIO shows and conferences, and
on the BIO web site. As part of the joint marketing agreement, we agreed to
discount the fees we charge to BIO members and contribute cash payments to a
joint marketing fund, to be used in connection with both parties' obligations
under the joint marketing agreement. In addition, we sold 187,500 shares of our
common stock to BIO for a nominal amount in consideration for BIO's
participation in these joint marketing activities. BIO is an industry
organization that serves and represents the biotechnology industry, including
more than 850 biotechnology companies, academic institutions, and state
biotechnology centers, with 25 state affiliates and related organizations in 47
states and more than 26 countries. In addition to other industry supporting
activities, BIO provides strategic purchasing services for its members through
BIO Purchasing, BIO's national group purchasing division.

 Our Technology

   The Chemdex Marketplace is a purchasing solution that resides entirely on
our servers and is accessible by standard browsers, requiring minimal software
installation at the customer site, and enabling rapid deployment of
applications, enhancements and updates. Our production data center is hosted at
Exodus Communication in Sunnyvale, California. This data center provides us
with conditioned space and high bandwidth Internet connectivity.

   System Architecture. The Chemdex Marketplace includes three layers of
technology:

  . Process and Communication Layer. This layer integrates our system with
    our customers' client applications using Internet technology protocols
    that can pass through an enterprise's network security wall, such as
    http, ftp and EDI, to provide a seamless operation of the Chemdex
    Marketplace and purchasing solution. This layer is implemented using
    standard web servers, and supports standard Internet protocols such as
    http, ftp and XML.

  . Electronic Services Layer. This layer delivers all of our system's
    functionality. The Chemdex Marketplace and purchasing solution uses
    existing and proprietary software to deliver proprietary services
    including Internet catalog development and maintenance tools, search
    functionality, workflow integration, product pricing and estimated
    shipping, handling and freight charges.

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  . Enterprise Services Layer. This layer delivers some of the services
    required to run Chemdex's system, including financial services,
    development and maintenance of the product master database, customer
    service systems and the data warehouse. To meet our unique scale
    requirements for product information management, we developed a
    proprietary data warehouse system.

   Customer Integration. The Chemdex Marketplace can be configured and
integrated to meet an enterprise customer's needs, including:

  . Customer View. The purchasing solution graphical user interface may be
    tailored for each enterprise customer, allowing an enterprise customer to
    select specific suppliers from our supplier list, and to customize the
    user's view in accordance with business rules and policies implemented by
    the purchasing department.

  . Login and Authentication. For enterprises that do not have a single
    authoritative directory services system enabling single login
    functionality across the enterprise, the Chemdex purchasing solution
    provides an authoritative enterprise authentication and authorization
    list along with the user roles, credit limits, and approval workflow. For
    enterprises that have a single authoritative directory services system,
    the Chemdex purchasing solution directly integrates with the enterprise's
    authoritative data source to maintain the current permitted user list,
    and provides seamless access by the user and simple management for the
    enterprise.

  . Purchasing Application Integration. The Chemdex purchasing solution
    integrates with commercial purchasing applications, such as Ariba or
    Commerce One, as well as internally developed purchasing applications,
    through Open Buying on the Internet, commonly known as OBI, an industry
    standard protocol for Internet purchasing, or by integrating directly
    with a proprietary format such as Ariba"s cXML protocol.

  .Custom Pricing. We have developed algorithms to support existing contract
    pricing agreements between customers and suppliers. This custom pricing
    can be implemented either by (a) pricing contract tables that list
    discount rates for a specific product, buyer or supplier relationship; or
    (b) direct integration with the supplier systems to extract real time
    pricing and availability information.

   Search Services. Our search software leverages a combination of full text
search and relational technology to deliver a unique search tool customized to
the life sciences industry. Our search engine is customized to 11 levels of
specific search categories associated with life sciences research products such
as antibodies, enzymes, or other compounds. Each of the product specific search
levels also includes parametric searching capabilities to search for products
with specific attributes, or ranges of attributes.

   Product Pricing Estimation. We have developed algorithms to estimate
shipping, handling and freight charges associated with any customer order.
These algorithms integrate customer requirements for shipping delivery time,
product weight, and product type (including requirements for hazardous
materials and product packaging such as blue ice). These algorithms provide our
users with estimated shipping, handling and freight cost, and make appropriate
decisions given their delivery timing requirements.

   Workflow. We have developed simple workflow technology to implement each
enterprise customer's business rules and processes. These workflow rules
include credit limit checks, multilevel approval and e-mail based notification
of any order changes. This system streamlines the purchasing process by
automating approval routing, and enables real time customer service through
direct customer notification.

   Technical Support. We offer technical support to respond to any customer
service disruption. In addition to off-the-shelf site instrumentation and
monitoring software, we have developed custom monitoring agents that measure
key Chemdex application parameters. This proprietary software enables us to
provide high quality technical support.

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 Sales, Marketing and Support

   We market and sell the Chemdex Marketplace and purchasing solution through a
combination of our direct sales force, internal telemarketing sales and
strategic relationships with partners such as VWR and BIO. Since our potential
customers and users fall within a defined market segment, we are able to
identify and target the purchasing decision makers and potential users who will
influence the decision to adopt a purchasing solution.

   Our sales and marketing approach is designed to help customers and suppliers
understand both the business and technical benefits of the Chemdex Marketplace
and purchasing solution, and to promote user adoption through one-on-one
education and training. Our field sales force focuses on large pharmaceutical
and biotechnology companies and large academic and research institutions. Our
telephone sales group focuses on small biotechnology companies and smaller
research institutions. We are building an experienced professional services
organization to facilitate the successful deployment of our purchasing
solution, including integration with any enterprise resource planning software
and customization with the enterprise's business rules. We intend to expand our
direct sales force and professional services organization and to establish
additional sales offices domestically and internationally. Competition for
sales personnel is intense, and we may not be able to attract, assimilate or
retain additional qualified personnel in the future.

   We conduct a variety of marketing programs to educate our target market,
create awareness and attract customers to our Chemdex Marketplace. To achieve
these goals, we leverage our existing customer base and engage in marketing
activities such as seminars, direct mailings, trade shows, speaking engagements
and web site marketing. We also conduct comprehensive public relations programs
that include establishing and maintaining relationships with key trade press,
business press and industry analysts. In addition, we engage in marketing
programs within our enterprise customers to educate, convert and train
researchers and purchasing agents to use the Chemdex Marketplace for their life
sciences research product orders.

   We believe that we can establish and maintain long-term relationships with
our customers and suppliers, and encourage repeat visits and purchases by our
customers if, among other things, we have good account management, customer
support and service. Our customer support and service personnel handle general
customer inquiries and basic technical questions, answer customer questions
about the ordering process and investigate the status of orders, shipments and
payments. We have automated some of the tools used by our customer support and
service staff, such as tracking screens that let our support staff track a
transaction by any of a variety of information sources. At any time in the
purchasing process, a customer can access our support staff by fax or e-mail by
following prompts located throughout our web site or by calling our call center
through our toll-free telephone line. Our support staff is knowledgeable in
life sciences research products and the life sciences industry.

   As of September 30, 1999, our worldwide sales and marketing group consisted
of 62 individuals, 51 of whom were located at our Palo Alto, California
headquarters and 11 of whom were located in regional offices in Ann Arbor,
Michigan; Cambridge, Massachusetts; Princeton, New Jersey; and Columbia,
Maryland.

 Research and Development

   Our development organization is focused on developing and enhancing our
enterprise purchasing solution, developing applications for and supporting the
Chemdex Marketplace, and maintaining and improving our technology,
infrastructure and database. The development group is supported by our quality
assurance group, which implements a process designed to identify defects
through the entire development cycle. We are currently in the process of
developing and integrating new technology into our Internet-based purchasing
solution as part of our planned release of several enhanced versions of the
Chemdex Marketplace over the next few months. These new releases are planned to
include significant enhancements to the user interfaces, database management
and search technology, and security controls, and will allow us to offer VWR's
products to our customers. As of September 30, 1999, our research and
development group was comprised of 71 employees responsible for development and
quality assurance.

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   Research and development expenses were $196,000 in 1997, $3.4 million in
1998 and $11.4 million during the first three quarters of 1999. To date,
substantially all software development costs related to the Chemdex Marketplace
have been expensed as incurred by our employees. We believe that significant
investments in research and development are required to remain competitive, and
will be made in the areas listed above.

 Proprietary Rights and Licensing

   Our success and ability to compete are dependent on our ability to develop
and maintain the proprietary aspects of our technology. We rely on a
combination of copyright, trademark and trade secret laws and contractual
restrictions to establish and protect the proprietary aspects of our
technology. We seek to protect our source code for our software, documentation
and other written materials under trade secret and copyright laws. Finally, we
seek to avoid disclosure of our intellectual property by requiring employees
and consultants with access to our proprietary information to execute
confidentiality agreements with us and by restricting access to our source
code.

   Despite our efforts to protect our proprietary rights, unauthorized parties
may attempt to copy aspects of our products or to obtain and use information
that we regard as proprietary. Litigation may be necessary in the future to
enforce our intellectual property rights, to protect our trade secrets, and to
determine the validity and scope of the proprietary rights of others. Any
resulting litigation could result in substantial costs and diversion of
resources and could have a material adverse effect on our business operating
results.

   Our success and ability to compete are also dependent on our ability to
operate without infringing upon the proprietary rights of others. In the event
of a successful claim of infringement against us and our failure or inability
to license the infringed technology, our business and operating results would
be significantly harmed.

 Competition in our Industry

   The market for business-to-business e-commerce and Internet ordering and
purchasing is new and rapidly evolving, and competition is intense and is
expected to increase significantly in the future. Barriers to entry are
relatively insubstantial. We believe that the critical success factors for
companies seeking to create Internet business-to-business e-commerce solutions
include the following:

  .quality and reliability of the Internet purchasing solution;

  .breadth and depth of product offerings;

  .brand recognition;

  .installed base of customers; and

  .ease of use and convenience.

   We face competition from four main areas: other companies with e-commerce
offerings, traditional suppliers and distributors of life sciences research
products, life sciences companies that have developed their own purchasing
solutions and enterprise software companies that offer, or may develop,
alternative purchasing solutions. Companies primarily focused on creating
Internet purchasing solutions for the life sciences industry include
SciQuest.com and Anderson Unicom Group, Inc. Traditional suppliers and
distributors including Sigma Aldrich Corp., Fisher Scientific International,
Inc., Merck KGaA Darmstaadt and VWR currently sell life sciences research
products through paper catalogs and web sites. We could face further
competition in the future from traditional suppliers and distributors that
enter into business-to-business e-commerce over the Internet either on their
own or by partnering with other companies. In addition, life sciences companies
may already have, or may develop, their own purchasing solutions. Traditional
enterprise software companies, such as SAP, IBM and Oracle, could in the future
develop and offer a competitive purchasing solution that our customers could
customize to link to their suppliers. Additionally, emerging enterprise
software companies, such as Ariba, Inc. and Commerce One, Inc. offer purchasing
solutions that could be customized to link to suppliers of life sciences
research products.

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   Our current and potential competitors may develop superior Internet
purchasing solutions that achieve greater market acceptance than our solution.
Many of our existing and potential competitors, including large traditional
distributors, have longer operating histories in the life sciences research
products market, greater name recognition, larger customer bases and
significantly greater financial, technical and marketing resources than we do.
Such competitors can undertake more extensive marketing campaigns for their
brands, products and services, adopt more aggressive pricing policies and make
more attractive offers to customers, potential employees, distribution
partners, commerce companies and third-party suppliers.

   In addition, substantially all of our prospective customers have established
long-standing relationships with some of our competitors or potential
competitors. Accordingly, we cannot be certain that we will be able to expand
our customer list and user base, or retain our current customers. We may not be
able to compete successfully against our current or future competitors and
competition could have a material adverse effect on our business, results of
operations and financial condition.

 Government Regulations

   In addition to regulations applicable to businesses generally, we are
subject to direct regulation by governmental agencies listed in the bullet
points below, which includes numerous laws and regulations generally applicable
to the chemical, pharmaceutical, controlled substances, human and biological
reagents, medical and in vitro devices, and nuclear chemical businesses, and
environmental spills, as well as U.S. import and export controls, and import
controls of other countries. We receive orders from purchasers for our products
that we then electronically transmit to the appropriate suppliers. The
suppliers then package, label and ship products directly to these purchasers.
We take legal title to the products, but do not take physical possession of a
shipment during any part of the transaction. Legal title generally passes to
the purchaser at the time of product shipment; however, if the chemicals or
other products are returned, we also have legal title during the shipment of
the returned products.

   We have been and intend to continue relying upon our suppliers to
appropriately package and label and maintain records on the products according
to local, state and federal laws. We have been and also intend to continue
relying upon suppliers to hold all appropriate licenses and approvals. We rely
on the suppliers' regulatory staff to confirm that the purchasers also have the
appropriate governmental licenses and permits and expertise needed to order,
receive and use any regulated products. We are unable to verify the accuracy of
our suppliers' regulatory staff determinations and their decisions whether or
not to ship a product to a purchaser.

   Our reliance on suppliers' regulatory due diligence assessment of purchasers
and the compliance by suppliers and purchasers with applicable governmental
regulations may not be sufficient if we are held to need our own licenses. For
example, if we are held by governmental agencies to be a seller or a
distributor of regulated products because we did take legal title, we may have
inadvertently violated some governmental regulations by not having the
appropriate license or permit and may be subject to potentially severe civil or
criminal penalties and fines for each offense. A review of these sales found
that they were generally made to academic or commercial purchasers and not to
individuals. As described below, our suppliers have indicated to us that they
regularly check the requisite licenses of purchasers. These facts could
minimize the potential severity of any civil or criminal penalties and fines
that could be imposed on us for each of these sales.

   We intend to continue to investigate our sales of regulated products and may
in the future voluntarily discuss with various governmental regulatory agencies
whether these sales required us, in addition to our suppliers, to obtain a
license or permit. We may also seek clarification of whether our prior sales of
these products will subject us to any governmental, civil or criminal
penalties, including monetary fines and injunctions or other enforcement
action. No assurance can be given by us that any penalties or fines will not
result in a material adverse effect on our business, results of operations or
financial condition. In addition, we may discover that we had inadvertently
sold other regulated products without a requisite license or permit or failed
to fully comply with other local, state, or federal laws governing these sales.

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   In addition to reviewing our past sales, during the period from May through
July,1999, we conducted interviews with those suppliers that accounted for
approximately 75% of prior sales. These suppliers were chosen as they are a
representative cross-section of our suppliers that we believe may sell
regulated products. We asked if they verify that the purchasers have the
necessary federal licenses before making shipments and if they comply with
applicable labeling and packaging requirements. We also asked the suppliers
whether they were aware of any diversions or chemical spills, or of any past,
pending, or threatened fines, violations, penalties, litigation, complaints or
investigations regarding their shipment of products to our customers. In the
course of these discussions, the suppliers informed us that they have
appropriate licenses and permits, and they routinely, as a matter of practice,
verify whether the purchasers have the relevant licenses or permits, comply
with labeling and packaging requirements, and are not aware of any diversions,
or past, pending or threatened fines, violations, penalties, litigation,
complaints, proceedings or investigations regarding their shipment of products
to our customers. However, some suppliers have had small spills and been
subject to fines for these spills and for failure to provide information on
hazards or health risks presented by products, but they could not identify
whether orders to Chemdex customers were involved. Furthermore, we are unable
to verify the accuracy of suppliers' statements that they have in the past
complied, or will in the future comply, with laws applicable to these sales. In
addition, we did not conduct investigations of all suppliers in the Chemdex
database, and we do not have any current plans to do so. We could be
significantly fined or exposed to significant civil or criminal liability, or
suffer negative publicity, if these licensing, packaging, labeling,
informational and other regulatory requirements have not been fully met by our
suppliers or by us directly.

   During the period from May through July, 1999, we also reviewed the list of
products in our current database to identify any products for which we may need
a license or permit to sell. We identified approximately 14,000 of those
products that may be regulated, and we have evaluated their status. They have
either been removed from our database, or been flagged so that we will not in
the future sell them, but instead will refer the purchasers of these flagged
products directly to suppliers. In some instances, we may also seek appropriate
licenses or registrations enabling us to return certain products to the
inventory. We cannot be sure that all regulated products requiring us to have a
license to sell have been removed from, or flagged in the database. In
addition, new products that require us to obtain governmental licenses or
permits may be inadvertently added to our database. We intend to begin
instituting new quality control procedures to routinely screen our growing
database, as well as increase the scrutiny of new products proposed to be added
to the database to eliminate those products for which we are required to have
licenses or permits to sell or distribute. Alternatively, we may apply for
appropriate licenses or registrations, in some instances, so certain products
may be returned to the inventory. A regulatory compliance officer has recently
been hired to oversee these matters, as well as the overall compliance of
Chemdex.

   Under the terms of our agreement with VWR, VWR provides support for the
purchase of third-party products, where purchasers may order products not
listed in our database. The type and nature of these products cannot be
anticipated. To help avoid inadvertent future sales of products for which we
would be required to hold governmental licenses or permits, we intend to
institute a new screening procedure to identify any requests for purchases of
those products and refer the purchaser directly to the suppliers, so that we
are not involved in sales of these third-party products. We cannot be sure that
we may not inadvertently sell or cause to be sold and shipped products for
which governmental licenses or permits are required.

   We have also relied on our suppliers to comply with applicable local, state
and federal laws regarding the labeling and the dissemination of information on
any products sold that may be hazardous or present a health threat to the user.
If these suppliers have failed, or fail in the future, to adequately comply
with labeling and information dispensing requirements of local, state or
federal laws, then we may be held legally responsible, since we briefly held
title to these products, and could be subject to governmental penalties or
fines, as well as private lawsuits to enforce these laws.

   Finally, we have relied upon our suppliers to obtain appropriate approvals
for products regulated by the U.S. Food & Drug Administration (FDA) and to
comply with the requirements relating to those approvals and

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products. The failure to obtain or comply with those approvals, or other
failures by the products themselves or the failure to keep regulatory records
required by the FDA, such as complaint files, distribution and other
requirements, or make adverse event reports to the FDA, could result in costly
product recalls, significant fines and judgments, civil and criminal
liabilities, and negative publicity.

   We intend to offer for sale products only to qualified purchasers. Unless we
have the necessary licenses, permits and authorizations, or an exemption or
exclusion applies, we do not intend to offer for sale or cause to be sold
products that are, for example:

  . prescription or over-the-counter human or animal drugs that are regulated
    by the U.S. Food and Drug Administration (FDA);

  . radioactive materials that are regulated by the Nuclear Regulatory
    Commission or state and local governmental authorities unless we have
    appropriate licenses or permits;

  . biological products intended for the treatment of humans or animals, and
    that are regulated respectively by the FDA and U.S. Department of
    Agriculture (USDA);

  . pathogenic bacteria or viruses that may introduce any contagious or
    infectious disease of man or animal and which are regulated by the
    Centers for Disease Control and Prevention and USDA;

  . controlled substances that are regulated by the Drug Enforcement Agency
    and whose distribution requires a registration;

  . products to be imported or exported (no products are currently exported)
    that are regulated by the U.S. Department of Commerce or other regulatory
    agencies;

  . explosive materials for which a license, permit, or authorization is
    required under Bureau of Alcohol, Tobacco and Firearms regulations; and

  . ozone-depleting substances that are subject to production and importation
    bans under the Federal Clean Air Act and the Montreal protocol.

   We intend to continue to sell products for which we do not need a license,
permit, or authorization, or for which an exemption or exclusion applies, and
will seek to comply, either directly or through our supplier, with applicable
local, state and federal laws and regulations governing the sale, packaging and
labeling of these products, dispensing of information on health risks and
hazards about a chemical, and recordkeeping concerning these products. However,
our suppliers and we may inadvertently fail to comply with applicable laws in
the future. Noncompliance could have a materially adverse impact on our
business, results of operations and financial condition because of civil or
criminal penalties and fines and negative publicity.

   For sales of VWR core products under our agreement with VWR and under
agreements with a limited number of other suppliers, we act as a sales agent.
In these situations, we do not take title to, or have possession of these
suppliers' products. We rely on VWR and these other suppliers to comply with
all applicable local, state and federal laws. Although we are acting as a sales
agent for these suppliers and do not take legal title to, or possession of,
these products, we may still be held liable if we cause to be sold regulated
products to purchasers who lack required licenses to use, store and receive
these products and if the suppliers of these products have failed to adequately
comply with local, state or federal laws.

   Researchers and others who are not affiliated with an enterprise customer
may register to purchase through our website, www.chemdex.com. Although we
require unaffiliated users to provide information about themselves, we do not
independently verify the accuracy of this information. Because we do not
generally meet unaffiliated users in person or visit their work sites, we are
even less able to gauge whether they have appropriate storage facilities,
permits or licenses, compared to enterprise customers with whom we generally
have some direct contact or knowledge of their reputations. Therefore, we
cannot be sure that we will not inadvertently sell, cause to be sold or
delivered, products for which the purchasers lack appropriate local, state

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or federal licenses or permits or expertise or experience to handle or use
these products. We may also be subject to significant civil or criminal
penalties, fines or monetary judgments as well as negative publicity, if
purchasers misuse or spill, or injure themselves or third parties with, the
products purchased from us.

   We are unaware of any current investigations, inquiries, citations, fines,
or allegations of violations or noncompliance pending by government agencies or
by third parties against us. It is possible that there may be investigations or
allegations we are not aware of or future investigations or allegations. We are
currently reviewing applicable requirements with regard to past, present and
continuing compliance, particularly concerning various licensing and sales
issues. The risk that any noncompliance may be discovered in the future is
currently unknown. Although any potential impact on us for noncompliance cannot
currently be established, it could result in significant civil or criminal
penalties, including monetary fines and injunctions, for noncompliance and
negative publicity, and have a material adverse impact on our business,
revenues, results of operations and financial condition.

   Due to the increasing popularity and use of the Internet, it is possible
that a number of laws and regulations may be adopted or interpreted in the
United States and abroad with particular applicability to the Internet. It is
also possible, in addition to the above-listed examples of existing laws and
regulations, as well as new tax laws and regulations, that new laws and
regulations may be adopted or interpreted by the United States and foreign
governments, to address the sale and distribution of products utilizing the
Internet. In addition, it is possible that governments will enact legislation
that may be applicable to us in areas such as content, product distribution,
network security, encryption and the use of key escrow, data and privacy
protection, electronic authentication or "digital" signatures, illegal and
harmful content, access charges and re-transmission activities. Moreover, the
applicability to the Internet of existing laws governing issues such as
property ownership, content, taxation, defamation, personal privacy, product
liability and environmental protection, as well as the necessity for
governmental permits, labeling, certifications and the need to supply
information to relevant parties, is uncertain. Most of these laws were adopted
before the widespread use and commercialization of the Internet and, as a
result, do not contemplate or address the unique issues of the Internet and
related technologies. Any export or import restrictions, new legislation or
regulation or governmental enforcement of existing regulations may limit the
growth of the Internet, increase our cost of doing business, or increase our
legal exposure. Any of these factors could have a negative effect on our
business, revenues, results of operations and financial condition.

 Employees

   As of September 30, 1999, we had 175 full-time employees, including 71 in
engineering, 74 in supplier relations and sales and marketing, and 30 in
general and administrative functions. We also employ independent contractors to
support our engineering, marketing, sales and support, and administrative
organizations.

 Facilities

   Our executive, administrative and operating offices are located in
approximately 33,000 square feet of leased office space located in Palo Alto,
California under a lease expiring in December, 2003. We also maintain sales
offices in Ann Arbor, Michigan; Cambridge, Massachusetts; Princeton, New
Jersey; and Columbia, Maryland. We are currently relocating our executive,
administration and operating offices to new facilities at 1500 Plymouth Street,
Mountain View, California, which have approximately twice the square footage of
our current facilities. We expect our move will be completed within the next
three months.

 Legal Proceedings

   Chemdex is not a party to any legal proceedings which, if adversely decided,
would reasonably be expected to have a materially adverse effect on the
financial condition of the corporation.

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<PAGE>

                              CHEMDEX CORPORATION

                         SELECTED FINANCIAL INFORMATION
                     (In thousands, except per share data)

<TABLE>
<CAPTION>
                                          Nine Months
                                             Ended             Year Ended
                                         September 30,        December 31,
                                        -----------------  --------------------
                                          1999     1998     1998       1997
                                        --------  -------  -------  -----------
                                                                    (inception)
<S>                                     <C>       <C>      <C>      <C>
Statements of Operations Data:
Net revenues..........................  $ 11,561  $     4  $    29    $  --
Operating loss........................   (34,790)  (4,298)  (8,796)     (403)
Net loss..............................   (33,313)  (4,090)  (8,488)     (403)
Basic and diluted net loss per share..  $  (3.33) $ (2.37) $ (4.79)   $(0.24)
Weighted average common shares--basic
 and diluted..........................    10,007    1,724    1,772     1,704

Balance Sheet Data:
Cash and cash equivalents.............  $125,563  $ 2,649  $ 5,990    $1,346
Working capital.......................   117,913    9,161    4,490     1,116
Total assets..........................   154,795   10,889    8,168     1,728
Long-term debt and capital lease
 obligations, net of current portion..       590        1      --          6
Total liabilities.....................    15,582      376    1,820       280
Total stockholders' equity............   139,213   10,513    6,348     1,448
</TABLE>

                                      105
<PAGE>

  MANAGEMENT'S DISCUSSION AND ANALYSIS OF RESULTS OF OPERATIONS AND FINANCIAL
                                   CONDITION

   The following "Management's Discussion and Analysis of Results of Operations
and Financial Condition" contains forward-looking statements. In some cases,
readers can identify forward-looking statements by terminology such as "may,"
"will," "should," "could," "expects," "plans," "anticipates," "believes,"
"estimates," "predicts," "potential," or "continue." These statements involve
known and unknown risks, uncertainties and other factors that may cause
Chemdex's actual results, performance, or achievements to be materially
different from those stated herein. Although management of Chemdex believes
that the expectations reflected in the forward-looking statements are
reasonable; the Company cannot guarantee future results, performance, or
achievements. For further information, refer to Management's Discussion and
Analysis and the Risk Factors section of Chemdex's Registration Statement on
Form S-1 (File Number 333-78505), as amended, and Chemdex's 10-Q.

Overview

   Chemdex is a leading provider of e-commerce solutions to the life sciences
research products market. The Chemdex Marketplace is a secure, Internet-based
purchasing solution that enables enterprises, researchers and suppliers to
efficiently buy and sell life sciences research products.

   We were formed in September 1997 and began offering products for sale on the
Chemdex Marketplace in November 1998. During the period from September 1998
through November 1998, we were a development stage enterprise and did not have
significant sales. Our operating activities during this period were related
primarily to the design and development of the Chemdex Marketplace, building
our corporate infrastructure, establishing relationships with suppliers and
customers and raising capital. To date, revenues have been derived from sales
of life sciences research products through the Chemdex Marketplace and through
our strategic relationship with VWR. We have grown our organization by hiring
personnel in key areas, particularly sales, research and development and
marketing.

Nine-month Period Ended September 30, 1999

   We have incurred significant losses since inception, including $14.0 million
in the third quarter of 1999, and, as of September 30, 1999, we had an
accumulated deficit of approximately $42.2 million. We believe our success
depends on establishing additional key strategic supplier and customer
relationships, enhancing the features and functionality of the Chemdex
Marketplace and enterprise purchasing solution, and accelerating market
awareness and demand for the Chemdex Marketplace. From inception, we have
increased our level of spending to build our infrastructure and to develop our
Chemdex Marketplace. We intend to continue to invest heavily in sales,
marketing and research and development and administrative activities and to
increase other operating expenses as required to integrate the operations and
technologies of any future acquisitions. We anticipate that these expenses
could significantly precede any revenues generated by this increased spending.
We have limited operating history upon which to base an evaluation of our
business and we cannot assure you that our revenues will increase in future
periods. Our business and prospects must be considered in light of the risks,
expenses and difficulties frequently encountered by companies in early states
of development, particularly companies in new and rapidly evolving markets such
as Internet-based business-to-business commerce.

   Our gross margin for the three months ended September 30, 1999 was
approximately 4.8%. Distributors in general operate on very low margins. This
is especially true in the life sciences research products market. Our gross
margins on sales of life sciences research products are small relative to the
margins earned by traditional distributors of life sciences research products.
If we are unable to increase our revenues at a greater rate than our related
costs, our margins may be reduced further, or possibly eliminated, which would
have a significant negative impact on our financial results. We are dependent
on the discounts we receive from our suppliers, and thus we are vulnerable to
any potential decrease in these discount rates. Any such decrease would have a
significant negative impact on our financial results. If we do not increase
these discounts, and substantially

                                      106
<PAGE>

increase our revenues and scale our business in a manner that generates
significant operating efficiencies, including further automation of our
purchasing solution, we may not be able to achieve profitability.

   Our gross profit margins on sales of VWR-distributed products are lower than
our margins on the other supplier products that we offer. We generate no gross
margin on sales of VWR-distributed products purchased through our Chemdex
Marketplace by VWR's current top forty customers. In addition, we receive
minimal margins on the sale of third party products. To the extent sales of
VWR-distributed products or third party products increase relative to, or
displace, our sales of other supplier products, our average gross margins will
likely decline, which would make it more difficult to achieve profitability.

   Sales to four significant customers accounted for approximately 32%, 16%,
15%, and 11% respectively, of our revenues in the quarter ended September 30,
1999, and we currently expect to continue to derive a significant portion of
our revenues from these customers for the foreseeable future. Our agreement
with one customer, in connection with its role as our initial test location for
our purchasing solution, provides that Chemdex will not receive price discounts
on products of some suppliers purchased by that customer if that customer
purchases specified minimum quantities of product through the Chemdex
Marketplace. As a result, we receive little or no gross margins on sales of
these supplier products to that customer. The loss of revenues from any of our
significant customers would have a significant negative effect on our business,
revenues, results of operations and financial condition.

   A key element of our strategy is to market our solution directly to life
sciences organizations, and to succeed we must satisfy the purchasing
departments, information technology groups and the individual researchers who
are the users of our Internet-based purchasing solution. The time it takes to
sell and implement our solution is long and we devote significant sales,
marketing and management resources to the sales process without any assurance
that the customer will use the Chemdex Marketplace. We are generally required
to provide a significant level of education regarding the use and benefits of
our Internet-based purchasing solution, due in part to the significant
departure from traditional means of commerce and communications entailed by its
adoption and use. Further, potential enterprise customers and a number of their
departments typically engage in extensive internal reviews and analyses before
making purchase decisions. The sale and implementation of our solution are
subject to delays due to our customers' internal budgets and procedures for
approving capital expenditures and deploying new technologies within their
networks. These delays also impair our ability to generate revenue and could
negatively affect our results of operations. Once an enterprise customer adopts
our Internet-based purchasing solution, it takes time for researchers and other
users within the enterprise to become aware of, learn to use and begin using
our Chemdex Marketplace. The long sales cycle and the time it takes for
researchers to begin using our Internet-based purchasing solution, could
negatively affect our revenue growth, and makes it difficult to predict our
results of operations.

   During the first quarter of 1999, we entered into an agreement with VWR
Scientific Products Corporation to jointly market VWR laboratory products using
the Chemdex e-commerce platform. The agreement gives us the right to offer
approximately 350,000 VWR-distributed products to our customers through the
Chemdex Marketplace. VWR and Chemdex are jointly developing an Internet
purchasing solution for VWR's existing and future customers that will provide
access to three categories of products:

  .  products distributed by VWR (VWR core products),

  .  products distributed by Chemdex (Chemdex core products), and

  .  products that are not distributed by either VWR or Chemdex but are
     purchased from third parties (third-party products).

   We act as an intermediary under this agreement and forward orders for VWR
core products received through the Chemdex Marketplace to VWR for fulfillment
and customer service. We receive no fee for orders from VWR's 40 largest
customers and we receive a minimal fee for all other orders forwarded to VWR.
We are responsible for fulfillment and customer service for all Chemdex core
product orders and orders for third

                                      107
<PAGE>

party products from VWR customers received through the Chemdex Marketplace on
similar terms and conditions as our other enterprise customers. VWR provides
services in connection with purchasing third-party products for a processing
fee paid by Chemdex. VWR and Chemdex jointly market the co-branded version of
the Chemdex Marketplace to VWR's existing and new customers, and jointly
solicit several key existing VWR suppliers to distribute, market and sell their
products through the co-branded purchasing solution.

   In connection with the strategic relationship with VWR, Chemdex issued
2,538,405 shares of common stock valued at $13.9 million. The fair value of the
stock is being amortized, on a straight-line basis, into sales and marketing
expense over four years, the estimated useful life of this intangible asset.

   We also entered into a five-year, exclusive joint marketing agreement with
the Biotechnology Industry Organization (BIO), and sold 187,500 shares of our
common stock to BIO for a nominal amount of consideration. We recorded the
difference between the nominal amount per share price paid by BIO and the fair
value as of the date of issuance, which is approximately $1.8 million as an
intangible asset which is being amortized over the five-year term of the joint
marketing agreement as a sales and marketing expense. Amortization related to
the VWR and BIO agreements for the three and nine months ended September 30,
1999 was $1.0 million and $1.6 million respectively.

Results of Operations for the Three and Nine Months Ended September 30, 1999

 Net revenues

   Net revenues increased from zero in the third quarter of 1998 to $8.5
million in the third quarter of 1999. For the nine months ended September 30,
1999, net revenues increased by $11.6 million from the same period in the prior
year. The significant growth in product sales was due to the launch of the
Chemdex Marketplace in the fourth quarter of 1998, and sales generated as a
result of the VWR agreement. Further, revenues have increased significantly due
to the increase in customer base and increased market acceptance. Net revenues
consist primarily of product sales to customers and charges to customers for
outbound freight. Under most of our supplier agreements we are acting as a
principal in purchasing products from our suppliers and reselling them to our
customers so that we recognize revenues equal to the amount paid by our
customers and cost of revenues equal to the amount we pay to our suppliers for
these products. Under our principal-based agreements, we are responsible for
selling the products, collecting payment from customers, ensuring that the
shipment reaches customers and processing returns. In addition, we take title
to products upon shipment and bear the risk of loss for collection, delivery
and merchandise returns from customers. Some of our agreements with our
suppliers treat us as an agent of the supplier, in which case we receive a
percentage fee on product sales. We recognize revenue from product sales, net
of any discounts, and from fees under our agency-based supplier agreements,
when the products are shipped to customers. Products are shipped directly to
customers by suppliers based on customer delivery date specifications.

 Cost of Revenues and Gross Profit

   Cost of revenues increased from zero in the third quarter of 1998 to $8.1
million in the third quarter of 1999. For the nine months ended September 30,
1999, cost of revenues increased by $11.0 million from the same period in the
prior year. Cost of revenues consists primarily of the costs of acquiring
products from our suppliers for sale to our customers. During the three and
nine months ended September 30, 1999, cost of revenues, in absolute dollars,
increased consistent with the significant increases in revenues. Our gross
margin for the quarter ended September 30, 1999 was approximately 4.8%. The low
gross margin on product sales, primarily all of which were recognized under
principal-based agreements, was due to our accepting low margins in order to
increase early sales volume, customer adoption, and awareness of the Chemdex
brand. Further, gross margins will fluctuate period to period based on the
product mix sold during the period. While margins on recently signed supplier
agreements continue to improve, we expect margins to remain low until we are
able to renegotiate higher discounts on earlier supplier agreements, and
increase volumes of revenues through more recently signed suppliers with higher
gross margins.

                                      108
<PAGE>

 Operating Expenses

   Research and Development. Research and development expenses increased from
$1.0 million in the third quarter of 1998 to $5.6 million in the third quarter
of 1999. For the nine month period ended September 30, 1999, research and
development costs increased by $9.6 million from the same period in the prior
year. Research and development expenses consist of personnel and other expenses
associated with developing, updating, and enhancing software in support of the
Chemdex Marketplace. Our research and development expenses have increased each
quarter since inception primarily due to increased staffing and associated
costs related to the design and development and maintenance of the Chemdex
Marketplace, and content and design expenses. We believe that our success is
dependent in large part on continued enhancement and development of the Chemdex
Marketplace. Accordingly, we expect research and development expenses to
continue to increase in future periods.

   Sales and Marketing. Sales and marketing costs increased from $.7 million in
the third quarter of 1998 to $6.9 million in the third quarter of 1999. For the
nine month period ended September 30, 1999, sales and marketing expenses
increased $14.1 million over the same period in the prior year. Sales and
marketing expenses consist primarily of advertising and promotion in support of
the development of our marketing strategy, payroll and related expenses for
personnel engaged in supplier relations, enterprise sales activities,
enterprise account management, and amortization expenses related to our VWR and
BIO agreements. Sales and marketing expenses have increased since inception as
we have continued to expand our sales and marketing efforts primarily with
relation to our corporate marketing and branding strategy. We intend to
continue to aggressively expand our supplier and customer relationships and to
expand our brand awareness. We expect sales and marketing expenses to increase
in future periods.

   General and Administrative. General and administrative costs increased from
$.5 million in the third quarter of 1998 to $2.6 million in the third quarter
of 1999. For the nine months ended September 30, 1999, general and
administrative costs increased by $6.1 million from the same period in the
prior year. General and administrative expenses consist primarily of salaries,
fees for professional services and lease expenses. General and administrative
expenses have increased primarily as a result of the addition of finance and
administrative personnel, costs of leasing additional office space to support
our growth, and expenses related to increased professional service fees. We
expect general and administrative expenses to increase in future periods to
support our expanded operations.

   Amortization of Deferred Compensation. We have recorded aggregate deferred
compensation charges of $8.7 million in connection with some of the stock
options we granted through September 30, 1999. For the quarter ended September
30, 1998 and 1999, we expensed $.1 million and $.5 million, respectively,
related to the amortization of deferred compensation. Further, for the nine
months ended September 30, 1998 and 1999, we expensed $.2 million, and $1.4
million respectively, related to the amortization of deferred compensation. The
deferred compensation amounts are being amortized over the vesting period of
the stock options which is generally four years. The total changes to be
recognized in future periods from amortization of deferred stock compensation
are anticipated to be approximately $0.5 million, $2.2 million, $2.2 million,
$1.8 million, and $0.1 million for the remaining three months of 1999, and for
the fiscal years 2000, 2001, 2002 and 2003, respectively.

   Interest Expense. Interest expense increased from zero in the third quarter
of 1998 to $60,000 in the third quarter of 1999. For the nine month period
ended September 30, 1999, interest expense increased $107,000 from the same
period in the prior year. Interest expense consists primarily of interest
related to financed equipment and other financing arrangements.

 Interest and other Income, Net

   Interest and other income, net increased from $.1 million in the third
quarter of 1998 to $1.3 million in the third quarter of 1999. Further, for the
nine month period ended September 30, 1999, interest and other income, net
increased $1.4 million from the same period in the prior year. Interest and
other income, net has been

                                      109
<PAGE>

derived primarily from earnings on investments in cash equivalent securities.
Interest during the third quarter of 1999 increased significantly due to
increased cash and cash equivalents resulting from our initial public offering
on July 27, 1999.

 Income Taxes

   We incurred operating losses and accordingly did not record a provision for
income taxes for any of the periods presented. At December 31, 1998, we had net
operating loss carryforwards and federal tax credits for federal income tax
purposes of $7.5 million and $100,000, respectively. In addition, we had state
net operating loss and research and development credit carryforwards of
approximately $7.4 million and $100,000, respectively. These net operating
losses and credits will expire in the years 2002 through 2018 if not utilized.
Certain future changes in our share ownership, as defined in the Tax Reform Act
of 1986 and similar state provisions, may restrict the utilization of
carryforwards. A valuation allowance has been recorded for the entire deferred
tax asset as a result of uncertainties regarding the realization of the assets
due to our lack of earnings history.

Liquidity and Capital Resources for the Nine Months Ended September 30, 1999

   In July 1999, we completed the initial public offering of our common stock
and realized net proceeds from the offering of approximately $117.6 million. As
of September 30, 1999, our principal sources of liquidity included
approximately $125.6 million of cash and cash equivalents, $4.1 million in
equipment financing arrangements, and $1.0 in other financing arrangements. The
equipment arrangements include an agreement for $1.1 million that provides for
12 equal quarterly payments of the financed amount commencing May 1, 1999, with
interest of approximately 13% per year, and a $3.0 million equipment lease line
agreement with a financial institution for a term of 48 months, with interest
of approximately 13% per year. The other lease arrangements include an
agreement for $1.0 million that provides for 29 equal monthly payments
commencing August 27, 1999, with interest of approximately 7% per year. At
September 30, 1999 there was $1.0 million in borrowings outstanding under the
equipment financing arrangements, and $.9 million under other financing
arrangements.

   Net cash used in operating activities totaled $22.4 million and $4.1 million
in the first nine months of 1999 and 1998, respectively. The net cash used in
operating activities in the first nine months of 1999 was primarily due to our
net losses, which were partially offset by non-cash charges of depreciation and
amortization of deferred compensation, amortization of intangible assets, and
increases in accounts payable, accrued liabilities, and accrued compensation.

   Net cash used in investing activities totaled $5.7 million in the first nine
months of 1999. We have made substantial investments in computer equipment,
computer software, office furniture and leasehold improvements during the
current year. Net cash used in investing activities in the first nine months of
1998 was $7.6 million and primarily related to purchases of short term
investments, computer equipment, and office furniture.

   Net cash provided by financing activities was $147.7 million in the first
nine months of 1999 and $13.0 million for the first nine months of 1998. Net
cash from financing activities during 1998 resulted primarily from the sale of
preferred stock. Net cash provided by financing activities was $147.7 million
in the first nine months of 1999, resulting primarily from the sale of
preferred and common stock partially offset by payments made on notes payable.

   We currently anticipate that cash and cash equivalents at September 30,
1999, together with our equipment lease line, will be sufficient to meet our
anticipated cash needs for working capital and capital expenditures for at
least the next 12 months. However, we may need to raise additional funds in
future periods through public or private financing, or other arrangements to
fund our operations and potential acquisitions, if any, over a long-term basis
until we achieve profitability, if ever. Any additional financing, if needed,
might not be available on reasonable terms or at all. Failure to raise capital
when needed could seriously harm our business and results of operations. If
additional funds are raised through the issuance of equity securities, the
percentage of ownership of our stockholders would be reduced. Furthermore,
these equity securities might have rights, preferences or privileges senior to
our common stock.


                                      110
<PAGE>

Three Month Period Ended March 31, 1999

   Our gross margin for the three months ended March 31, 1999 was approximately
5.8% and was trending downward.

   Genentech, Inc. accounted for approximately 82% of our revenues in the
period ended March 31, 1999, and we currently expect to continue to derive a
significant portion of our revenues from Genentech for the forseeable future.
Our agreement with Genentech, in connection with its role as our initial test
location for our purchasing solution provides that Chemdex will not receive
price discounts on products of some suppliers purchased by Genentech if
Genentech purchases specified minimum quantities of product through the Chemdex
Marketplace. As a result, we receive little or no gross margins on sales of
these supplier products to Genentech. The loss of revenues from Genentech, or
the negotiation by other large enterprise customers for similar programs, would
have a significant negative effect on our business, revenues, results of
operations and financial condition.

   We recorded deferred compensation for options granted in 1998 and the three
months ended March 31, 1999. As of March 31, 1999 we had recorded aggregate
deferred stock compensation of $6.2 million. The deferred stock compensation is
being amortized over the vesting periods of the stock options. We recognized a
total of $372,285 and $352,291 in stock compensation expense during 1998 and
the three months ended March 31, 1999, respectively.

Quarterly Results of Operations

   Because we were a development stage company during 1997 and 1998 and have a
short operating history, we believe that period-to-period comparisons prior to
1999 are less meaningful than an analysis of recent quarterly operating
results. Accordingly, we are providing a discussion and analysis of our results
of operations that is focused on the six quarters in the period ended March 31,
1999.

   The following table presents our unaudited quarterly operating results for
the six quarters in the period ended March 31, 1999. You should read the
following table together with our financial statements and related notes in
this prospectus. We have prepared this unaudited information on the same basis
as the audited financial statements. This table includes all adjustments,
consisting only of normal recurring adjustments, that we consider necessary for
a fair presentation of our financial position and operating results for the
quarters presented. You should not draw any conclusions about our future
results from the operating results of any quarter.

<TABLE>
<CAPTION>
                                         Three Months Ended
                          ----------------------------------------------------
                                             June     Sept.    Dec.     Mar.
                          Dec. 31, Mar. 31,   30,      30,      31,      31,
                            1997     1998    1998     1998     1998     1999
                          -------- -------- -------  -------  -------  -------
                                           (in thousands)
<S>                       <C>      <C>      <C>      <C>      <C>      <C>
Statements of Operations
 Data:
Net revenues.............  $  --    $  --   $     3  $    --  $    26  $   165
Cost of revenues.........     --       --        --       --       22      156
                           -----    -----   -------  -------  -------  -------
Gross profit.............     --       --         3       --        4        9
Operating expenses:
  Research and
   development...........    196      364       414    1,026    1,635    2,293
  Sales and marketing....     86      219       297      710    2,021    3,188
  General and
   administrative........    121      190       422      489      644    1,015
  Amortization of
   deferred
   compensation..........     --       22        44      104      202      352
                           -----    -----   -------  -------  -------  -------
  Total operating
   expenses..............    403      795     1,177    2,329    4,502    6,848
                           -----    -----   -------  -------  -------  -------
Operating loss...........   (403)    (795)   (1,174)  (2,329)  (4,498)  (6,839)
Interest and other
 income, net.............     --        2        70      136      100       30
                           -----    -----   -------  -------  -------  -------
Net loss.................  $(403)   $(793)  $(1,104) $(2,193) $(4,398) $(6,809)
                           =====    =====   =======  =======  =======  =======
</TABLE>


                                      111
<PAGE>

Results of Operations

 Net Revenues

   From inception through November 1998, Chemdex was in the development stage
and had only nominal net revenues. Net revenues increased to $165,000 in the
quarter ended March 31, 1999 as it was the first full quarter in which the
Chemdex Marketplace was operational. Net revenues consist primarily of product
sales to customers and charges to customers for outbound freight.

 Cost of Revenues

   Cost of revenues consists primarily of the costs of acquiring products from
our suppliers for sale to our customers. During the quarter ended March 31,
1999, cost of revenues increased primarily due to the increase in revenues.
Cost of revenues is expected to increase in future periods reflecting increases
in sales volume. Our gross margin for the quarter ended March 31, 1999 was
approximately 5.8%. The low gross margin on product sales, primarily all of
which were recognized under principal-based agreements, was due to our
accepting low margins in order to increase early sales volume, customer
adoption, and awareness of the Chemdex brand. We expect margins to remain low
until we are able to negotiate larger discounts from our suppliers.

 Operating Expenses

   Research and Development. Research and development expenses consist of
personnel and other expenses associated with developing and enhancing software
in support of the Chemdex Marketplace. Our research and development expenses
have increased each quarter since inception primarily due to increased staffing
and associated costs related to the design and development and maintenance of
the Chemdex Marketplace, and content and design expenses. We believe that our
success is dependent in large part on continued enhancement of the Chemdex
Marketplace. Accordingly, we expect research and development expenses to
increase in future periods.

   Sales and Marketing. Sales and marketing expenses consist primarily of
advertising and promotion in support of the development of our marketing
strategy and payroll and related expenses for personnel engaged in supplier
relations and sales activities. Sales and marketing expenses have increased
since inception as we have expanded our sales and marketing efforts. We intend
to aggressively expand our supplier and customer relationships and to increase
revenues and expand our brand awareness. Consequently, we expect to increase
the sales and marketing expenses in future periods. In addition, sales and
marketing expenses will increase significantly due to our recently established
relationships with BIO and VWR.

   General and Administrative. General and administrative expenses consist
primarily of salaries, fees for professional services and lease expenses.
General and administrative expenses have increased primarily as a result of the
addition of finance and administrative personnel and the costs of leasing
additional office space to support our growth, as well as expenses related to
increased professional service fees. We expect general and administrative
expenses to increase in future periods to support our expanded operations and
the expenses of being a public company.

   Amortization of Deferred Compensation. We recorded aggregate deferred
compensation of $6.2 million in connection with some of the stock options we
granted through March 31, 1999. For the year ended December 31, 1998 and the
three months ended March 31, 1999, we amortized $372,000 and $352,000,
respectively, related to stock options. In April 1999, we recorded additional
deferred compensation of $2.5 million related to stock option grants. The
deferred compensation amounts are being amortized over the vesting period of
the stock options, generally four years. See Note 6 of Notes to Financial
Statements.

 Interest and Other Income, Net

   Interest and other income, net has been derived primarily from earnings on
cash investments, offset by interest expense associated with our capitalized
lease obligations for equipment purchases.

                                      112
<PAGE>

 Income Taxes

   We incurred operating losses and accordingly did not record a provision for
income taxes for any of the periods presented. At December 31, 1998, we had net
operating loss carryforwards and federal tax credits for federal income tax
purposes of $7.5 million and $100,000, respectively. In addition, we had state
net operating loss and research and development credit carryforwards of
approximately $7.4 million and $100,000, respectively. These net operating
losses and credits will expire in the years 2002 through 2018 if not utilized.
Certain future changes in our share ownership, as defined in the Tax Reform Act
of 1986 and similar state provisions, may restrict the utilization of
carryforwards. A valuation allowance has been recorded for the entire deferred
tax asset as a result of uncertainties regarding the realization of the assets
due to our lack of earnings history. See Note 8 of Notes to Financial
Statements.

VWR Transaction

   In connection with our agreement with VWR, VWR transferred to us information
concerning VWR customers who purchased products from third party suppliers
outside of VWR's primary product offering, and in exchange we issued shares of
common stock to VWR. We intend to use this information to expand sales of our
purchasing solution to these customers and adoption of the Chemdex Marketplace
by these customers and suppliers. The deemed fair value of the common stock is
being amortized as sales and marketing expense over four years, the estimated
useful life of this intangible asset. The annual amortization will be
approximately $3.5 million.

Liquidity and Capital Resources for the Three Months Ended March 31, 1999

   We funded our operations primarily through the private sale of our equity
securities, through which we raised net proceeds of approximately $42.8 million
through the quarter ended March 31, 1999. We also financed our operations
through equipment lease financing. As of March 31, 1999, our principal sources
of liquidity included approximately $27.8 million of cash and cash equivalents
and $4.1 million in equipment financing arrangements. The arrangements include
an agreement with Oracle Credit Corporation for $1.1 million that provides for
12 equal quarterly payments of the financed amount commencing May 1, 1999, with
interest imputed at 13.24% per year, and a $3.0 million equipment lease line
agreement with a financial institution for a term of 48 months, with interest
imputed at 13.02% per year. At March 31, 1999 there was $1.1 million in
borrowings outstanding under the equipment financing arrangements. Subsequent
to March 31, 1999, in April 1999, we raised an additional approximately $2.3
million in net proceeds from the private sale of our Series C Preferred Stock.

   Cash used in operating activities totaled $6.8 million in 1998 and $4.6
million for the quarter ended March 31, 1999, primarily due to our net losses,
which were partially offset by non-cash charges of depreciation and
amortization of deferred compensation and sales and marketing and interest
expense related to warrants and increases in accounts payable and accrued
expenses.

   Cash used in investing activities totaled $1.6 million in 1998 and $1.5
million for the quarter ended March 31, 1999. We have made substantial
investments in computer equipment, computer software, office furniture and
leasehold improvements.

   Net cash provided by financing activities was $13.0 million in 1998 and
$27.9 million for the quarter ended March 31, 1999. Net cash from financing
activities during 1998 and for the quarter ended March 31, 1999 resulted
primarily from the sale of preferred stock. We expect to fund future operating
expenses from revenues received from the sale of our products, public or
private financing and the proceeds of this offering.

   We currently anticipate that the net proceeds from this offering, together
with our current cash, cash equivalents, and equipment lease line, will be
sufficient to meet our anticipated cash needs for working capital and capital
expenditures for at least the next 12 months. However, we may need to raise
additional funds in

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<PAGE>

future periods through public or private financings, or other arrangements to
fund our operations and potential acquisitions, if any, over a long-term basis
until we achieve profitability, if ever. Any additional financings, if needed,
might not be available on reasonable terms or at all. Failure to raise capital
when needed could seriously harm our business and results of operations. If
additional funds are raised through the issuance of equity securities, the
percentage of ownership of our stockholders would be reduced. Furthermore,
these equity securities might have rights, preferences or privileges senior to
our common stock.

Year 2000 Compliance

   Many currently installed computer systems and software products are unable
to distinguish year 2000 dates. This situation could result in system failures
or miscalculations causing disruptions in the operations of any business. As a
result, many companies' software and computer systems may need to be upgraded
or replaced to comply with year 2000 requirements. Our ability to operate is
dependent upon delivery of accurate, electronic information via the Internet.
To the extent year 2000 issues result in the long-term inoperability of the
Internet or the Chemdex Marketplace, our business, results of operations and
financial condition could be seriously harmed.

   We completed an assessment of our information technology systems for year
2000 problems in April 1999. We have not replaced any of our systems based on
the results of our assessment. However, we have made modifications to some
systems based on our assessment of year 2000 problems.

 Representations and Warranties to Our Customers

   We generally represent and warrant to our customers that the occurrence of
the date January 1, 2000 and any related leap-year issues will not cause the
Chemdex Marketplace application software to fail to operate properly. Our
warranty generally applies only to our software and excludes failures resulting
from the combination of our software and other software or hardware,
unauthorized changes to the software or network connectivity problems,
including, without limitation, problems connecting to the Internet or problems
relating to Internet service providers. If we breach this warranty, the
recourse that our customers may seek is limited to the prompt correction by us
at our own expense of any failure of our software to the reasonable
satisfaction of the customer.

 Our Testing of Our Online Marketplace Application Software

   We have internally reviewed the Chemdex Marketplace application software. We
have performed industry-standard procedures to test our internally developed
applications for year 2000 compliance. Based on our testing, we believe that
our internally developed applications and systems are designed to be year 2000
compliant. In addition, we hired a consultant to perform additional testing,
including a year 2000 readiness audit of our internally developed online
application software. The consultant's audit report concluded that our online
application software is year 2000 compliant.

   Assessment of Third-Party Equipment and Software. We utilize third-party
equipment and software that may not be year 2000 compliant. Failure of third-
party equipment or software, or the interface of our applications with this
equipment or software, could result in a material adverse effect on our
business, results of operations and financial condition. We have finished
assessing the year 2000 risks of our third-party desktop systems that are
unrelated to the Chemdex Marketplace. We have contacted the vendors of most of
our third-party software and equipment to assess the year 2000 risks of our
third-party systems that are unrelated to the Chemdex Marketplace. We have
received year 2000 compliance letters from some of these vendors. We are also
in the process of contacting the few remaining vendors with whom we have not
yet spoken in order to assess their year 2000 compliance. Based on these
vendors' representations, we have put a plan in place to upgrade our third-
party systems in order to be year 2000 compliant. The failure of these vendors
to address year 2000 issues may require us to seek alternative vendors or, if
possible, to develop our own solutions. The time and resources required to find
alternative vendors and to transition our systems could increase our costs of
doing business, require to find alternative vendors and to transition our
systems could increase our costs of doing business, require us to allocate our
own resources away from our core business, and delay development of our own
technology and operations.

                                      114
<PAGE>

   Interaction of Our Marketplace with Supplier and Customer
Systems. Furthermore, the success of our efforts may depend on the success of
our suppliers, customers and strategic partners in dealing with their year 2000
issues. Many of these organizations' systems may not yet be year 2000 compliant
and the impact of failure of these systems on the Chemdex Marketplace is
difficult to determine. The availability of products from our suppliers and the
purchasing patterns of our customers or potential customers may be affected by
year 2000 issues.

   In addition, until some of the billing and cash collection functions for the
sale of third-party products are transitioned to us, we are dependent upon
VWR's systems, which may not be year 2000 compliant, for receiving payment for
third-party products. If the systems of any of our suppliers or customers, and
particularly, if VWR's billing and cash collection systems, are not year 2000
compliant, our business, revenues, results of operations and financial
condition could be severely harmed.

   According to its public filings, VWR is in the process of implementing
enhancements to its computer systems to satisfy its future requirements. During
1998, VWR purchased an enterprise-wide computer system package that is
replacing many of VWR's systems, including order entry, purchasing, and
financial systems. VWR completed the initial rollout of the new systems during
the fourth quarter of 1998. VWR had an external review conducted by an
independent information technology consulting firm to identify legacy computer
systems that could be affected by the year 2000 issue, when they would be
affected, and how the year 2000 issues may be remedied. The extent of year 2000
remediation performed by VWR was coordinated with the new systems
implementation timetable. VWR is still transitioning to its new system as of
September 30, 1999. VWR's new system, together with other planned system
changes, was intended to address its year 2000 issues.

 Our Contingency Planning Effort

   We are engaged in an ongoing year 2000 assessment and are gathering
information for the development of contingency plans. We are in the process of
contacting our strategic partners and major customers to gauge their year 2000
compliance and request year 2000 compliance information and letters. The nature
and extent of our contingency plans will depend on the responses received from
our critical suppliers, strategic partners and major customers. We have
identified our worst-case scenario resulting from a year 2000 failure. We have
a contingency plan in place that will be continually updated and implemented as
we get closer to year end.

 Costs of Addressing Year 2000 Compliance

   To date, our costs to address year 2000 compliance have been approximately
$700,000 and are included in operating expenses funded from working capital. We
anticipate the additional costs to address year 2000 compliance will be
approximately $300,000. We currently have not deferred other information
technology projects due to our year 2000 efforts. Any year 2000 compliance
problem experienced by us, our customers, suppliers or strategic partners could
decrease the demand for or availability of products.

Recent Accounting Pronouncements

   In June 1998, the FASB issued FAS 133, Accounting for Derivative Instruments
and Hedging Activities, which we will be required to adopt for the year ending
December 31, 2000. This statement establishes a new model for accounting for
derivatives and hedging activities. FAS 133 establishes methods of accounting
for derivative financial instruments and hedging activities related to those
instruments as well as other hedging activities. Because we currently hold no
derivative financial instruments and do not currently engage in hedging
activities, adoption of FAS 133 is expected to have no material impact on our
financial condition or results of operations.

   In March 1998, the American Institute of Certified Public Accountants
(AICPA) issued Statement of Position (SOP) No. 98-1, Accounting for the Costs
of Computer Software Developed or Obtained for Internal Use. SOP No. 98-1
requires entities to capitalize some of the costs related to internal-use
software once the

                                      115
<PAGE>

applicable criteria have been met. We expect that the adoption of SOP No. 98-1
will not have a material impact on our financial position or results of
operations. We will be required to implement SOP No. 98-1 for the year ending
December 31, 1999.

   In April 1998, the AICPA issued SOP 98-5, Reporting for the Costs of Start-
Up Activities. SOP No. 98-5 requires that all start-up costs related to new
operations to be expensed as incurred. In addition, all start-up costs that
were capitalized in the past must be written off when SOP No. 98-5 is adopted.
We expect that the adoption of SOP No. 98-5 will not have a material impact on
our financial position or results of operations. We will be required to
implement SOP No. 98-5 for the year ending December 31, 1999.

Quantitative and Qualitative Disclosures About Market Risk

   Our sales from inception to date have been made to U.S. Customers and, as a
result, we have not had any exposure to factors such as changes in foreign
currency exchange rates or weak economic conditions in foreign markets.
However, in future periods, we expect to sell in foreign markets. As our sales
are made in U.S. dollars, a strengthening of the U.S. dollar could make our
products less competitive in foreign markets. At September 30, 1999, our cash
and cash equivalents consisted primarily of money market funds and commercial
paper held by large institutions in the U.S.

Factors Affecting Future Results

   The following discussion should be read in conjunction with the consolidated
financial statements and notes thereto included herein.

   Chemdex desires to take advantage of the "safe harbor" provisions of the
Private Securities Litigation Reform Act of 1995. Specifically Chemdex wishes
to alert readers that, except for the historical information contained in this
Management's Discussion and Analysis of Financial Condition and Results of
Operations, the matters discussed herein are forward-looking statements that
are subject to certain risks and uncertainties that could cause the actual
results to differ materially from those projected. Factors that could cause
actual results to differ materially include, but are not limited to, outcomes
in litigation proceedings, market demand for Chemdex's products, the timing of
orders and shipments, the timely development and market acceptance of new
products and surgical procedures, the impact of performance of Chemdex's
distributors and direct sales force, Chemdex's ability to further expand into
international markets, public policy relating to health care reform in the
United States and other countries, approval of its products by government
agencies such as the United States Food and Drug Administration, and other
risks detailed below and included from time to time in Chemdex's other SEC
reports and press releases, copies of which are available from Chemdex upon
request. Chemdex assumes no obligation to update any forward-looking statements
contained herein. The factors listed under "Factors Affecting Future Results,"
as well as other factors, have in the past affected, and could in the future
affect, Chemdex's actual results and could cause Chemdex's results for future
periods to differ materially from those expressed in any forward-looking
statements contained in the following discussion.

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<PAGE>

                               CHEMDEX MANAGEMENT

Directors and Executive Officers

   Set forth below is information regarding the directors and executive
officers of Chemdex as of September 30, 1999.

<TABLE>
<CAPTION>
   Name                     Age Position
   ----                     --- --------
<S>                         <C> <C>
David P. Perry.............  31 President, Chief Executive Officer and Director

Pierre V. Samec............  36 Chief Information Officer

Robin A. Abrams............  48 Chief Operating Officer

James G. Stewart...........  46 Chief Financial Officer and Assistant Secretary

Martha D. Greer............  46 Vice President, Marketing

Thomas P. Kudrycki.........  41 Vice President, Engineering

Derek McCall...............  40 Vice President, Special Projects

Robert W. Perreault........  42 Vice President, Professional Services

James S. Wambach...........  46 Vice President, Worldwide Sales

David A. Weber.............  46 Vice President, Supplier Relations

Charles R. Burke(1)........  56 Director

Brook H. Byers(1)..........  53 Chairman of the Board

Jonathan D. Callaghan(1)...  30 Director

Jerrold B. Harris..........  56 Director

S. Joshua Lewis(2).........  35 Director

John A. Pritzker...........  45 Director

Naomi O. Seligman..........  66 Director

Robert A. Swanson..........  51 Director

L. John Wilkerson(2).......  55 Director
</TABLE>
- --------
(1) Member of the Compensation Committee.
(2) Member of the Audit Committee.

   David P. Perry co-founded Chemdex in September 1997 and has served as its
President, Chief Executive Officer and a director since September 1997. From
December 1995 to April 1997, he co-founded and served in various positions,
including Chief Executive Officer, of Virogen, Inc., a biotechnology company.
Mr. Perry has also held various positions at Exxon Corporation, including as a
Refinery Operations Supervisor from January 1994 to May 1995, a financial
analyst from March 1993 to January 1994, a project manager from September 1992
to March 1993 and an engineer from September 1990 to March 1992. Mr. Perry
holds an M.B.A. from Harvard University and a B.S. in chemical engineering from
the University of Tulsa.

   Pierre V. Samec joined Chemdex as its Chief Information Officer in July
1998. He previously held various positions at Charles Schwab and Co., Inc., a
financial services company, including as its Senior Vice President, Retail
Technology from January 1998 to July 1998, its Vice President, Software
Engineering from July 1996 to

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<PAGE>

February 1998 and its Vice President and Architect from January 1996 to June
1996. Mr. Samec also served as the Vice President, Software Engineering of
Quintus Corporation, a software company, from August 1993 to December 1995. Mr.
Samec holds an engineering degree from Ecole des Mines de Paris and a Ph.D.
from Stanford University.

   Robin A. Abrams has served as the Chief Operating Officer of Chemdex since
June 1999. Prior to joining Chemdex, Ms. Abrams served as the President of Palm
Computing Inc. and the Senior Vice President of 3Com Corporation from February
1999 to June 1999. Ms. Abrams served as the President of VeriFone Inc., a
secured payment systems company and a subsidiary of Hewlett-Packard, from March
1998 to February 1999, and as the Vice President of the Americas of VeriFone
from February 1997 to March 1998. From June 1996 to February 1997, Ms. Abrams
was the Senior Vice President of Apple Computer, Inc. and the President of
Apple Americas, and from December 1994 to June 1996, Ms. Abrams served as the
Vice President and General Manager of Apple Asia. Ms. Abrams holds a B.S. and a
J.D. degree from the University of Nebraska.

   James G. Stewart joined Chemdex as its Chief Financial Officer in February
1999. Previously, Mr. Stewart served as the Chief Financial Officer of CN
Biosciences, Inc., a chemical manufacturing and distribution company, from June
1995 to March 1999, and the President of CN Corporation, the principal
operating division of CN Biosciences, Inc., from March 1998 to March 1999. From
April 1994 to April 1995, Mr. Stewart served as the Chief Financial Officer of
Fightertown Entertainment, Inc., a virtual reality entertainment company. From
November 1988 to April 1994, Mr. Stewart held various positions at Verteq,
Inc., a semiconductor equipment company, including most recently as its Chief
Financial Officer. Mr. Stewart was formerly an Audit Partner of Arthur Young &
Co. and holds a B.S. from the University of Southern California.

   Martha D. Greer joined Chemdex as its Vice President, Marketing in January
1999. Previously, she served as the Vice President, Merchandise Management of
Onsale, Inc., an electronic commerce company, from December 1996 to November
1998. Ms. Greer was employed as an independent consultant from January to
December 1996. From 1992 to 1996, Ms. Greer served in various positions at PC
Connection, a computer direct marketing company, including as its Vice
President, Product Management from September 1994 to February 1996, as its Vice
President, Marketing from September 1993 to September 1994, as its Director,
Marketing from May 1993 to September 1993 and as its Director, Business
Development from November 1992 to May 1993. Ms. Greer holds a B.A. in
linguistics from Macalester College and a Ph.D. in experimental psychology from
Harvard University.

   Thomas P. Kudrycki joined Chemdex as its Vice President, Engineering in
September 1998. Previously, from January 1996 to July 1998, Mr. Kudrycki served
as the Vice President, Content Technology of CNET, an online publishing
company. From September 1988 to December 1995, he served as a technical manager
at AT&T Corporation, a voice and data communications company. Mr. Kudrycki
holds a B.Eng. in Physics from Warsaw Polytechnic, a B.S. in computer science
from Central State University and a M.S. in electrical and computer engineering
from University of Cincinnati.

   Derek McCall joined Chemdex as its Vice President, Special Projects in June
1999. Previously, he served as the President of Alfa Aesar, a research
chemicals company and wholly-owned subsidiary of Johnson Matthey PLC, from
January 1992 to May 1999. Previously, from April 1990 to December 1991, he
served as the Sales and Marketing Director of the Catalysts and Chemicals
Division of Johnson Matthey Inc., an advanced materials company. Mr. McCall
holds a B.Sc. Joint Honours degree in Zoology and Oceanography from the
University of Swansea, South Wales, and is a member of the Institute of
Marketing.

   Robert W. Perreault joined Chemdex as its Vice President, Professional
Services in April 1999. From February 1998 to April 1999, he served as Vice
President of Worldwide Professional Services at Inprise Corporation, an
enterprise software and services company. From August 1995 to February 1998,
Mr. Perreault was Vice President of Professional Services and Vice President of
Engineering at Visigenic Software, Inc., which was acquired by Inprise in March
1998. Prior to 1990, Mr. Perreault held various senior management positions at
Compuware Corporation, Uniface Corporation and Hewlett-Packard Company, most
recently serving as Vice President of Client Server Technology. Mr. Perreault
holds a B.A. from Stanford and an M.B.A. from the University of Michigan.

                                      118
<PAGE>

   James S. Wambach has served as the Vice President, Worldwide Sales of
Chemdex since September 1998. From January 1997 to June 1998, Mr. Wambach
served as the Senior Vice President of North American Sales Operations of Forte
Software, Inc., a software company. From January 1990 to December 1996, Mr.
Wambach served in various positions at Sybase, Inc., a software products and
services company, including most recently as its Vice President and General
Manager from October 1995 to December 1996. Mr. Wambach has also served in
various positions at Oracle Corporation, a database management and business
applications company. Mr. Wambach holds a B.S. degree in business
administration from Ohio State University.

   David A. Weber joined Chemdex in February 1999 as its Vice President,
Supplier Relations. Previously, Mr. Weber served as the Vice President,
Marketing at Amersham Pharmacia Biotech, a scientific services and tools
company, from October 1997 to February 1999. He also served as the Vice
President, Direct Marketing from 1995 to 1997 and as Area Director from 1990 to
1995, of Pharmacia Biotech, a division of Pharmacia & Upjohn, Inc. He holds a
B.S. in biochemistry from Rutgers University.

   Charles R. Burke has served as a director of Chemdex since January 1998. Mr.
Burke has served as the President of Monument Partners, Inc., a consulting
firm, since January 1998. From January 1994 to December 1997, he served as the
Chief Executive Officer of Research Biochemicals Incorporated, a research
reagent supply company. Mr. Burke is also a director of Endogen, Inc. Mr. Burke
holds an A.B. in Chemistry from Cornell University, a M.A. with honors in
Biology from Colgate University and a Ph.D. in Biochemistry from the University
of Illinois.

   Brook H. Byers has served as a director of Chemdex since May 1998 and as
Chairman of the Board since March 1999. Mr. Byers is a general partner of
Kleiner Perkins Caufield & Byers, a venture capital firm which he joined in
1977. He was the founding president and chairman of four lifesciences
companies: Hybritech Inc., IDEC Pharmaceuticals Corporation, InSite Vision Inc.
and Ligand Pharmaceuticals Inc. Mr. Byers currently serves as a director of
Nanogen, Inc. and a number of privately-held technology companies. Mr. Byers
serves on the Board of Directors of the University of California, San Francisco
Foundation and the California Healthcare Institute. Mr. Byers holds a B.S. in
electrical engineering from Georgia Institute of Technology and an M.B.A. from
the Stanford Graduate School of Business.

   Jonathan D. Callaghan has served as a director of Chemdex since September
1997. Mr. Callaghan has been a general partner of CMG@Ventures, a venture
capital firm, since September 1997. Previously, from June 1991 to June 1995,
Mr. Callaghan was an associate of Summit Partners, a venture capital firm. He
holds a B.A. from Dartmouth College and an M.B.A. with Distinction from Harvard
University.

   Jerrold B. Harris has served as a director of Chemdex since April 1999. Mr.
Harris has been the President and Chief Executive Officer of VWR Scientific
Products Corporation, a scientific supplies and products company, since March
1990. Mr. Harris is a director of VWR and of the Provident Institutional Funds.

   S. Joshua Lewis has served as a director of Chemdex since May 1998. Mr.
Lewis is a Managing Director of E.M. Warburg, Pincus & Co., LLC and a director
of a number of privately held companies. Mr. Lewis holds a D.Phil. from Oxford
University and an A.B. from Princeton University.

   John A. Pritzker has served as a director of Chemdex since March 1998. Mr.
Pritzker served as a Divisional Vice President of Hyatt Hotels and Resorts from
1984 to 1988. In 1988, he founded Red Sail Merchandising/The Corporate Choice,
a sports, retail and entertainment company, and Mandara Spa LLC, a spa company.
Mr. Pritzker currently serves as President of Red Sail Sports, Mandara Spa LLC
and Hyatt Ventures, Inc., a venture capital firm. Mr. Pritzker served as
director of Ticketmaster Group, Inc. for five years. He holds an A.A. from
Menlo College.

   Naomi O. Seligman has served as a director of Chemdex since June 1999. Ms.
Seligman is a co-founder and has served as a senior partner of the Research
Board, Inc., an information technology research group, since 1975. Ms. Seligman
currently serves as a director of The Dun and Bradstreet Corporation, a
financial services company. Ms. Seligman holds a B.A. in economics with high
honors from Vassar College and a MBA from the London School of Economics.

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<PAGE>

   Robert A. Swanson has served as a director of Chemdex since May 1998. Mr.
Swanson has served as the Chairman and Chief Executive Officer of K&E
Management, a private investment company since October 1996. Previously, Mr.
Swanson co-founded and served as the Chief Executive Officer of Genentech,
Inc., a biotechnology company, from April 1976 to February 1990 and served as
its Chairman from February 1990 to December 1996. Prior to forming Genentech,
Mr. Swanson was a partner of Kleiner & Perkins, a venture capital firm. Mr.
Swanson holds a S.B. in chemistry from Massachusetts Institute of Technology
and a S.M. in management from the Alfred P. Sloan School of Management at
Massachusetts Institute of Technology.

   L. John Wilkerson has served as a director of Chemdex since March 1999. Dr.
Wilkerson is a co-founder and has been a general partner of Galen Associates, a
venture capital firm, since May 1990, and has been a consultant to The
Wilkerson Group, a health care products consulting firm, since May 1996.
Previously, Dr. Wilkerson served as a Vice President of Smith Barney. He is
currently a director of British Biotech Plc, Stericycle, Inc. and TheraTX,
Incorporated. Dr. Wilkerson holds a Ph.D. in economics from Cornell University
and a B.S. in plant science from Utah State University.

Board of Directors

   Directors are elected annually at the annual meeting of Chemdex
stockholders, and serve for the term for which they are elected and until their
successors are duly elected and qualified. Chemdex's Bylaws currently provide
for a Board of Directors comprised of ten directors.

Board Committees

   Chemdex's Board of Directors has an Audit Committee and a Compensation
Committee. The Audit Committee of the Board of Directors consists of Mr. Lewis
and Mr. Wilkerson. The Audit Committee reviews Chemdex's financial statements
and accounting practices and makes recommendations to the Board of Directors
regarding the selection of independent auditors. Mr. Lewis is the Chairman of
the Audit Committee. The Compensation Committee of the Board of Directors
consists of Messrs. Burke, Byers and Callaghan. The Compensation Committee
makes recommendations to the Board of Directors concerning salaries and
incentive compensation for Chemdex's officers and employees and administers
Chemdex's employee benefit plans. Mr. Byers is Chairman of the Compensation
Committee.

Director Compensation

   None of the directors is paid any fee or other compensation for acting as a
director, although directors are reimbursed for reasonable expenses incurred in
attending Board or committee meetings. Officers of Chemdex are appointed by the
Board of Directors and serve at its discretion. Directors who are employees of
Chemdex are eligible to participate in Chemdex's 1998 Stock Plan and, as of the
offering, they will also be eligible to participate in Chemdex's 1999 Employee
Stock Purchase Plan. Mr. Burke was granted an option to purchase 7,500 shares
of common stock under the 1998 Stock Plan at an exercise price of $.10 per
share in February 1998 and an additional option to purchase 17,500 shares of
common stock under the 1998 Stock Plan at an exercise price of $.15 per share
in July 1998. These options vest over a four-year period. Mr. Swanson was
granted an option to purchase 75,000 shares of common stock under the 1998
Stock Plan at an exercise price of $.10 per share in May 1998. Fifty percent of
these option shares were vested as of the date of grant and the remaining 50%
of these option shares vest over a four-year period. Beginning in 1999,
directors who are not employees of Chemdex will be eligible to participate in
Chemdex's 1999 Directors' Stock Plan. See "Stock Plans."

   Chemdex has entered into indemnification agreements with each member of the
Board of Directors and certain of its officers providing for the
indemnification of these persons to the fullest extent authorized, permitted or
allowed by law.

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<PAGE>

Compensation Committee Interlocks and Insider Participation

   None of the members of the Compensation Committee of the Board of Directors
is an officer or employee of Chemdex. No executive officer of Chemdex serves as
a member of the Board of Directors or compensation committee of any entity that
has one or more executive officers serving on Chemdex's Compensation Committee.

Executive Compensation

   The following table sets forth information concerning compensation earned in
the fiscal year ended December 31, 1998 paid to Chemdex's Chief Executive
Officer and Chemdex's next most highly compensated executive officers who
earned more than $100,000 during the fiscal year ended December 31, 1998
("Named Officers"). All options granted by the Board of Directors prior to
February 16, 1999 allowed for early exercise. The number of securities
underlying options in the "Long-Term Compensation" column includes securities
issued upon the exercise of options subject to repurchase at cost by Chemdex.

<TABLE>
<CAPTION>
                                                                     Long-Term
                                          Annual Compensation       Compensation
                                     ------------------------------ ------------
                                                          Other      Number of
                                                          Annual     Securities   All Other
                                      Salary   Bonus   Compensation  Underlying  Compensation
Name and Principal Position(1)  Year   ($)      ($)        ($)      Options (#)      ($)
- ------------------------------  ---- -------- -------- ------------ ------------ ------------
<S>                             <C>  <C>      <C>      <C>          <C>          <C>
David P. Perry(2)........       1998 $ 98,375 $ 20,000     $--            --         $--
 President, Chief
 Executive Officer and
 Director

Pierre V. Samec(3).......       1998   83,333  150,000      --        225,000         --
 Chief Information
 Officer

Scott Waterhouse(4)......       1998  150,070   27,237      --        132,890         --
 Vice President, Supplier
 Relations
</TABLE>
- --------
(1) Ms. Abrams, Chemdex's Chief Operating Officer, commenced employment with
    Chemdex in June 1999. Ms. Abrams' salary on an annualized basis for 1999 is
    $300,000, which does not include a signing bonus of $50,000 paid upon
    commencement of employment with Chemdex or any quarterly cash bonuses of
    $20,000 payable upon the achievement of performance goals. Mr. Stewart,
    Chemdex's Chief Financial Officer, commenced employment with Chemdex in
    February 1999. Mr. Stewart's salary on an annualized basis for 1999 is
    $200,000, which does not include a bonus of $50,000 payable upon the
    achievement of performance goals, housing expenses or an annual life
    insurance premium of approximately $9,000 per year paid for by Chemdex on
    behalf of Mr. Stewart. Ms. Greer, Chemdex's Vice President, Marketing,
    commenced employment with Chemdex in January 1999. Ms. Greer's salary on an
    annualized basis for 1999 is $200,000, which does not include a signing
    bonus of $75,000 paid upon commencement of employment with Chemdex or a
    bonus of $50,000 payable upon the achievement of performance goals.
(2) Mr. Perry founded Chemdex in September 1997. His salary on an annualized
    basis is currently $180,000. His salary was increased from $55,000 to
    $125,000 on May 11, 1998 to $180,000 on March 1, 1999. As of December 31,
    1998, Mr. Perry held 1,725,854 shares of common stock valued at $2,588,781
    based on a per share price of $1.50.
(3) Mr. Samec commenced his employment with Chemdex in July 1998. His salary on
    an annualized basis is $200,000. Mr. Samec earned a total bonus of $150,000
    in 1998, $25,000 of which was paid in 1999.
(4) Mr. Waterhouse terminated his employment with Chemdex in January 1999.

Stock Options

   The following table sets forth information concerning the grant of stock
options to the Named Officers during the fiscal year ended December 31, 1998.
The individual grants consist of options granted pursuant to

                                      121
<PAGE>

Chemdex's 1998 Stock Plan. For the purposes of calculating the percent of total
options granted to employees during the last fiscal year, Chemdex granted
options to purchase 1,978,835 shares of common stock to employees and
consultants. The exercise price per share of each option was equal to the fair
market value of common stock on the date of grant as determined by the Board of
Directors. In determining the fair market value of the common stock on each
grant date, the Board of Directors considered, among other things, Chemdex's
absolute and relative levels of revenues and operating results, the state of
Chemdex's technology development, increases in operating expenses, the absence
of a public trading market for Chemdex's securities, the intensely competitive
nature of Chemdex's market and the appreciation of stock values of generally
comparable companies. The potential realizable value is based on the assumption
that the common stock of Chemdex appreciates at the annual rate shown,
compounded annually, from the date of grant until the expiration of the ten-
year term. These numbers are calculated based on Securities and Exchange
Commission requirements and do not reflect Chemdex"s projections or estimates
of future stock price growth. Potential realizable values are computed by:

  . Multiplying the number of shares of common stock subject to a given
    option by the exercise price;

  . Assuming that the total stock value derived from that calculation
    compounds at the annual 5% or 10% rate shown in the table for the entire
    ten-year term of the option; and

  . Subtracting from that result the total option exercise price.

              Option Grants in Fiscal Year ended December 31, 1998

<TABLE>
<CAPTION>
                                          Individual Grants(1)        Potential Realizable
                         Number of  ---------------------------------   Value At Assumed
                         Securities     % of                          Annual Rates of Stock
                         Underlying Total Options                      Price Appreciation
                          Options    Granted to   Exercise               for Option Term
                          Granted   Employees in   Price   Expiration ----------------------
Name                        (#)      Fiscal Year   ($/Sh)     Date        5%        10%
- ----                     ---------- ------------- -------- ---------- ---------- -----------
<S>                      <C>        <C>           <C>      <C>        <C>        <C>
David P. Perry..........      --          -- %      $--         --    $      --  $      --
Pierre V. Samec(2)......  225,000       11.37        .15     9/1/08       21,225     53,789
Scott Waterhouse........  132,890        6.72        .10    1/21/08        8,357     21,179
</TABLE>
- --------
(1) Ms. Abrams was granted an option to purchase 250,000 shares of common stock
    on June 25, 1999 pursuant to Chemdex's 1998 Stock Plan. The exercise price
    per share is $10.00; the expiration date of the option is June 24, 2009 and
    the potential realizable values at assumed rates of stock appreciation for
    the option term are $1,572,237 at 5% and $3,984,356 at 10%, Mr. Stewart was
    granted an option to purchase 225,000 shares of common stock on February
    16, 1999 pursuant to Chemdex's 1998 Stock Plan. The exercise price per
    share of the option is $1.50; the expiration date of the option is February
    15, 2009 and the potential realizable values at assumed rates of stock
    appreciation for the option term are $212,252 at 5% and $537,888 at 10%.
  Ms. Greer was granted an option to purchase 225,000 shares of common stock
  on January 27, 1999 pursuant to Chemdex's 1998 Stock Plan. The exercise
  price per share of the option is $1.50; the expiration date of the option
  is January 26, 2009 and the potential realizable values at assumed rates of
  stock appreciation for the option term are $212,252 at 5% and $537,888 at
  10%. Ms. Greer was granted an additional option to purchase 10,000 shares
  of common stock on April 27, 1999 pursuant to Chemdex's 1998 Stock Plan.
  The exercise price per share of the option is $5.00; the expiration date of
  the option is April 26, 2009 and the potential realizable values at assumed
  rates of stock appreciation for the option term are $31,445 at 5% and
  $79,687 at 10%.
(2) Mr. Samec was granted an additional option to purchase 75,000 shares of
    common stock on April 27, 1999 pursuant to Chemdex's 1998 Stock Plan. The
    exercise price per share of the option is $5.00; the expiration date of the
    option is April 26, 2009 and the potential realizable values at assumed
    rates of stock appreciation for the option term are $235,835 at 5% and
    $597,653 at 10%.

                                      122
<PAGE>

Exercise of Options and Year-End Values

   The following table sets forth information concerning the exercise of stock
options during the fiscal year ended December 31, 1998 by the Named Officers
and the fiscal year-end value of unexercised options. Since there was no public
trading market for Chemdex's common stock as of December 31, 1998, the values
of unexercised options at December 31, 1998 are based on a fair market value of
common stock of $1.50 per share as determined by the Board of Directors on
January 27, 1999. Therefore, these values are calculated based on the $1.50 per
share value for value at fiscal year-end or the fair market value as determined
by the Board of Directors on the date of exercise for value realized, less the
applicable exercise price per share, multiplied by the number of shares
underlying these options. All options granted by the Board of Directors prior
to February 16, 1999 allowed for early exercise. The number of securities
underlying unexercised options in the "Unexercisable" column and the related
value of these securities at year end reflects this information as it relates
to options that although are exercisable, would if exercised result in the
ownership of common stock subject to repurchase at cost by Chemdex.

   Aggregated Option Exercises in Last Fiscal Year and Fiscal Year-End Option
                                     Values

<TABLE>
<CAPTION>
                                                     Number of Securities
                                                    Underlying Unexercised     Value of Unexercised
                                                          Options at           In-the-Money Options
                            Shares                   December 31, 1998 (#)   at December 31, 1998 ($)
                         Acquired on     Value     ------------------------- -------------------------
        Name(1)          Exercise (#) Realized ($) Exercisable Unexercisable Exercisable Unexercisable
        -------          ------------ ------------ ----------- ------------- ----------- -------------
<S>                      <C>          <C>          <C>         <C>           <C>         <C>
David P. Perry..........       --         $--          --           --          $--          $--
Pierre V. Samec(2)......   225,000         --          --           --           --           --
Scott Waterhouse(3).....   132,890         --          --           --           --           --
</TABLE>
- --------
(1) Ms. Abrams has not exercised any of her options. Mr. Stewart has not
    exercised any of his options. Ms. Greer exercised an option to purchase
    225,000 shares of common stock in February 1999 at an exercise price per
    share of $1.50.
(2) Does not include an option to purchase 75,000 shares of common stock
    granted to Mr. Samec in April 1999 at an exercise price per share of $5.00.
(3) Mr. Waterhouse exercised an option to purchase 132,890 shares of common
    stock in May 1998 at an exercise price per share of $.10.

                                      123
<PAGE>

                       CHEMDEX RELATED PARTY TRANSACTIONS

Equity Transactions

   In September 1997, Chemdex issued and sold 2,570,000 shares of common stock
to the founders of Chemdex, including 1,905,854 shares of common stock to Mr.
Perry, 25,700 shares of common stock to Mr. Callaghan, a director of Chemdex,
3,161 shares of common stock to Marc Kaschke and 635,285 shares of common stock
to Jeffrey Leane. In consideration for the receipt of assets contributed to
Chemdex, Mr. Callaghan paid $514.00 to Chemdex, Mr. Kaschke paid $63.22 to
Chemdex and Mr. Leane contributed $12,705.70 in the form of assets contributed
to Chemdex.

   In September 1997, Chemdex issued and sold 800,800 shares of its Series A
preferred stock at a price of $.6994 per share, including:

  . 357,000 shares to CMG@Ventures II, LLC (formerly CMG@Ventures, L.P.), an
    entity with which Mr. Callaghan, a director of Chemdex, is affiliated;

  . 357,500 shares to a partnership affiliated with Mr. Swanson, a director
    of Chemdex; and

  . two other private investors.

   In December 1997 and March 1998, Chemdex issued and sold 1,994,850 shares of
its Series A preferred stock at a price of $.6994 per share, including:

  . 1,115,400 shares to The Bay City Capital Fund I, L.P., an entity with
    which Mr. Pritzker, a director of Chemdex, is affiliated;

  . 14,300 shares to Mr. Burke, a director of Chemdex;

  . 715,000 shares to CMG@Ventures; and

  . other private investors.

   All of the Series A preferred stock converted into 2,795,650 shares of
common stock upon consummation of Chemdex's initial public offering in July
1999.

   In October 1997, Chemdex loaned $10,000 to Mr. Perry pursuant to a
promissory note bearing interest at a rate of 8% per annum which matured on
October 15, 1999. This note has been forgiven by the Board of Directors of
Chemdex.

   In May 1998, Chemdex issued and sold 8,649,992 shares of its Series B
preferred stock at a price of $1.50 per share, including:

  . 2,666,666 shares to entities affiliated with Kleiner Perkins Caufield &
    Byers, an entity with which Mr. Byers, a director of Chemdex, is
    affiliated;

  . 2,666,666 shares to Warburg, Pincus Ventures L.P., an entity with which
    Mr. Lewis, a director of Chemdex, is affiliated;

  . 1,236,526 shares to CMG@Ventures II, LLC, an entity with which Mr.
    Callaghan, a director of Chemdex, is affiliated;

  .1,285,987 shares to The Bay City Capital Fund I, L.P., an entity with
     which Mr. Pritzker is affiliated;

  .16,487 shares to Mr. Burke;

  .266,666 shares to a partnership affiliated with Mr. Swanson; and

  .other private investors.

                                      124
<PAGE>

   All of the Series B preferred stock converted into 8,649,992 shares of
common stock upon consummation of Chemdex"s initial public offering in July
1999.

   In March 1999 and April 1999, Chemdex issued and sold 5,299,951 shares of
its Series C preferred stock at a price of $5.716 per share, including:

  . 1,749,474 shares to entities affiliated with Galen Associates, an entity
    with which Dr. Wilkerson, a director of Chemdex, is affiliated;

  . 393,631 shares to entities affiliated with Kleiner Perkins Caufield &
    Byers, an entity with which Mr. Byers, a director of Chemdex, is
    affiliated;

  . 393,631 shares to Warburg, Pincus Ventures L.P., an entity with which Mr.
    Lewis, a director of Chemdex, is affiliated;

  . 393,631 shares to CMG@Ventures II, LLC, an entity with which Mr.
    Callaghan, a director of Chemdex, is affiliated;

  . 393,631 shares to The Bay City Capital Fund I, L.P., an entity with which
    Mr. Pritzker, a director of Chemdex, is affiliated;

  . 6,997 shares to Mr. Burke; and

  . other private investors.

   In addition, in March 1999, Chemdex issued warrants to purchase a total of
49,999 shares of common stock at an exercise price of $5.20 per share to
entities affiliated with Galen Associates, an entity with which Dr. Wilkerson,
a director of Chemdex, is affiliated.

   All of the Series C preferred stock converted into 5,299,951 shares of
common stock upon consummation of Chemdex's initial public offering in July
1999.

   In March 1999, Chemdex entered into a strategic relationship agreement with
VWR Scientific Products Corporation to jointly market VWR laboratory products
using the Chemdex Marketplace. The agreement gives us the right to offer
approximately 350,000 VWR core products to our customers through the Chemdex
Marketplace. VWR and Chemdex are jointly developing a hosted, co-branded
Internet purchasing solution for VWR's existing and future customers that will
provide access to VWR core products, Chemdex core products and products that
are not distributed by either VWR or Chemdex, but are purchased from third
parties. In connection with the strategic relationship agreement, VWR
transferred to Chemdex information concerning VWR customers who purchased
products from third party suppliers outside VWR's primary product offering and
in exchange Chemdex issued 2,538,405 shares of common stock valued at $13.9
million to VWR. VWR also entered into a standstill agreement limiting its
ownership in Chemdex to 10% of Chemdex's outstanding securities, including
outstanding options and warrants. This percentage can be exceeded if any one
company from a specified list of companies acquires more than 10% of Chemdex's
outstanding securities, including outstanding options and warrants. Mr. Harris,
a director of Chemdex, is President and Chief Executive Officer of VWR. Mr.
Harris became a director of Chemdex concurrent with the entrance into the
strategic relationship agreement.

   CMG@Ventures and its affiliates beneficially own 2,728,357 shares of Chemdex
common stock, representing approximately 8.3% of the outstanding Chemdex common
stock, and 3,996,800 shares of Promedix preferred stock, representing
approximately 42.3% of the outstanding Promedix capital stock. Following
consummation of the merger, CMG@Ventures and its affiliates will beneficially
own approximately 18.9% of the outstanding Chemdex common stock. Jonathan D.
Callaghan is a general partner of CMG@Ventures and is a member of both the
Chemdex board of directors and Promedix board of directors.

Other Transactions

   In January 1998, Chemdex entered into an Electronic Commerce Agreement with
Genentech, Inc., a company of which Mr. Swanson, a director of Chemdex, is a
founder and the former Chief Executive Officer and Chairman.

                                      125
<PAGE>

   In May 1998, Chemdex entered into a Stock Restriction Agreement with Mr.
Perry, pursuant to which shares held by Mr. Perry are subject to a repurchase
option in favor of Chemdex in accordance with the terms therein.

   In January 1999, Chemdex entered into a Separation Agreement with Scott
Waterhouse, pursuant to which Mr. Waterhouse received severance benefits upon
the termination of his employment with Chemdex.

   Some of the officers of Chemdex, including Ms. Abrams, Ms. Greer, Mr. Samec,
Mr. Wambach and Mr. Weber, will receive six months of accelerated vesting of
stock then held in the event of their termination without cause. In addition,
in the event of a termination with or without cause, Ms. Greer will receive the
greater of six months of then-current salary or $100,000, Ms. Abrams and Mr.
Samec will receive six months of then-current salary, Mr. Stewart and Mr. Weber
will receive the greater of six months of then-current salary or an amount
equal to salary for 15 months less the time they have been employed by Chemdex
and Mr. Wambach will receive the greater of six months of then-current salary
or $87,500. If Mr. Stewart is terminated without cause or resigns due to
pressing family concerns during the first six months of his employment, he will
receive an additional six months of vesting for his stock, and if after the
first six months, but during the first twelve months of employment, his stock
will vest in an amount equal to what he would have vested had he been employed
for the full twelve months. If Mr. Stewart is terminated without cause or
resigns due to pressing family concerns after the first twelve months but
during the first 24 months of his employment, his stock will vest in an amount
equal to what he would have vested had he been employed for the full 24 months.
In addition, Chemdex has entered into Change of Control Agreements with Ms.
Abrams, Ms. Greer, Mr. Kudrycki, Mr. Perreault, Mr. Perry, Mr. Samec, Mr.
Stewart, Mr. Wambach, Mr. Weber and other employees of Chemdex, where the
shares held by these employees shall become fully vested if (a) Chemdex is
merged into another entity or sold and (b) this employee is terminated by the
surviving entity without cause or within twelve months of the closing of the
transaction.

   Chemdex has also entered into a Change of Control Agreement with each of Mr.
Burke and Mr. Swanson, under which any options subject to vesting or shares
subject to a right of repurchase of Chemdex then held by Mr. Burke or Mr.
Swanson will become fully vested upon the closing of a merger in which more
than 50% of the total voting power of Chemdex is transferred or a sale of all
or substantially all of Chemdex's assets in a complete liquidation or
dissolution of Chemdex.

   Since inception, Chemdex from time to time has issued and sold shares of its
common stock and granted options to purchase common stock to its employees,
directors and consultants.

   The following executive officers have executed full-recourse promissory
notes in the amounts set forth after their names in connection with their
purchases of shares of Chemdex's common stock:

<TABLE>
<CAPTION>
                                                       Principal
        Name                                            Amount   Rate    Date
        ----                                           --------- ----  --------
   <S>                                                 <C>       <C>   <C>
   Martha D. Greer.................................... $337,455  4.71% 02/26/99
   Thomas P. Kudrycki.................................   22,470  4.64  01/22/99
   Pierre V. Samec....................................   33,705  5.12  10/21/98
   James S. Wambach...................................   33,705  4.64  01/22/99
   David A. Weber.....................................  299,970  4.71  02/26/99
</TABLE>

   These notes become due the earlier of five years after the date of issuance
or nine months after the date of this offering. They bear interest at the
lowest rate allowed under federal tax law to avoid the imputation of interest,
compounded annually.

   Except for the forgiveness of $10,000 promissory note held by Mr. Perry, the
related transactions were on terms that are no more favorable than those that
would have been agreed upon by third parties on an arm's length basis.

                                      126
<PAGE>

                       PRINCIPAL STOCKHOLDERS OF CHEMDEX

   The following table provides information regarding the beneficial ownership
of Chemdex's common stock as of September 30, 1999 by:

  . each person who is known by Chemdex to own beneficially 5% or more of
    Chemdex's common stock;

  . each of Chemdex's directors; and

  . Chemdex's chief executive officer and each of the other four most highly
    compensated executive officers.

   The following tables set forth as of September 30, 1999, certain information
with respect to the beneficial ownership of the common stock of Chemdex. The
number and percentage of Chemdex shares beneficially owned prior to the merger
are based on 32,775,335 shares of common stock outstanding as of September 30,
1999. The number and percentage of Chemdex shares beneficially owned after the
merger are based on 43,564,271 shares of common stock outstanding.

<TABLE>
<CAPTION>
                                                                Percentage of
                                                                   Shares
                                                                Beneficially
                                                    Number of       Owned
                                                      Shares    --------------
                                                   Beneficially Before  After
Name of Beneficial Owner                              Owned     Merger  Merger
- ------------------------                           ------------ ------  ------
<S>                                                <C>          <C>     <C>
Entities affiliated with Kleiner Perkins Caufield
 & Byers(/1/).....................................   3,060,297    9.3%    6.8
 2750 Sand Hill Road
 Menlo Park, CA 94025

Entities affiliated with Warburg, Pincus
 Ventures(/2/)....................................   3,060,297    9.3     6.8
 466 Lexington Avenue
 New York, New York 10017-3147

The Bay City Capital Fund I, L.P.(/3/)............   2,795,018    8.5     6.2
 750 Battery Street
 San Francisco, CA 94104

Entities affiliated with CMG@Ventures(/4/)........   2,728,357    8.3     6.1
 3000 Alpine Road
 Menlo Park, CA 94028

VWR Scientific Products Corporation...............   2,538,405    7.7     5.7
 1310 Goshen Parkway
 West Chester, PA 19380

Entities affiliated with Galen Associates(/5/)....   1,799,473    5.5     4.0
 610 Fifth Avenue, 5th Floor
 Rockefeller Center
 New York, NY 10020

David P. Perry....................................   1,725,854    5.3     3.8
Pierre V. Samec(/6/)..............................     225,000      *       *
Scott P. Waterhouse...............................      68,119      *       *
Charles R. Burke(/7/).............................      62,784      *       *
Brook H. Byers(/8/)...............................   3,060,297    9.3     6.8
S. Joshua Lewis(/9/)..............................   3,060,297    9.3     6.8
John A. Pritzker(/10/)............................       6,867      *       *
Jonathan D. Callaghan(/11/).......................  2, 728,357    8.3     6.1
Jerrold B. Harris(/12/)...........................   2,547,152    7.7     5.7
L. John Wilkerson(/13/)...........................   1,799,473    5.5     4.0
Robert A. Swanson(/14/)...........................     699,166    2.1     1.6
Naomi Seligman....................................       5,000      *       *
All executive officers and directors as a group
 (19 persons).....................................  16,794,255  51.24%  37.45%
</TABLE>

                                      127
<PAGE>

- --------
*   Less than 1%
 (1)Includes:
   . 2,748,148 shares held by Kleiner Perkins Caufield & Byers VIII, L.P.
   . 153,014 shares held by KPCB Life Sciences Zaibatsu Fund II, L.P. and
   . 159,135 shares held by KPCB VIII Founders Fund, L.P.
   The general partner of Kleiner Perkins Caufield & Byers VIII, L.P. and
   KPCB VIII Founders Fund is KPCB VIII Associates. The general partner of
   KPCB Life Sciences Zaibatsu Fund II, L.P. is KPCB VII Associates. Brook H.
   Byers, a director of Chemdex, is a general partner of the Kleiner Perkins
   Caufield & Byers funds. Mr. Byers disclaims beneficial ownership of the
   shares held by Kleiner Perkins Caufield & Byers VIII, L.P., KPCB Life
   Sciences Zaibatsu Fund II, L.P. and KPCB VIII Founders Fund, L.P., except
   to the extent of his pecuniary interest therein arising from his general
   partnership interest in these funds.
 (2) Warburg, Pincus & Co. is the sole general partner of Warburg, Pincus
     Ventures, L.P., which is managed by E.M. Warburg, Pincus & Co., LLC.
     Lionel I. Pincus is the managing partner of Warburg, Pincus & Co. and the
     managing member of E. M. Warburg, Pincus & Co., LLC, and may be deemed to
     control both entities.
 (3) Certain trusts for the benefit of the lineal descendants of Nicholas J.
     Pritzker, deceased (including Mr. Pritzker) are indirect investors in The
     Bay City Capital Fund I, L.P. Mr. Pritzker disclaims any beneficial
     ownership in the shares held by The Bay City Capital Fund I, L.P., except
     for 6,867 shares. Of the shares reported, certain individuals (including
     Mr. Pritzker) have beneficial ownership of 60,397 shares.
 (4) Includes:
   . 2,702,657 shares held by CMG@Ventures II, LLC and
   . 25,700 shares held by Johnathan D. Callaghan, a general partner of
     CMG@Ventures and a director of Chemdex.
   Mr. Callaghan disclaims beneficial ownership of the shares held by
   CMG@Ventures II, LLC except to the extent of his pecuniary interest
   therein arising from his general partnership interest in these funds.
 (5) Includes:
   . 1,598,260 shares and a warrant to purchase 45,678 shares of common stock
     exercisable within 60 days of September 30, 1999 held by Galen Partners
     III, L.P.
   . 144,670 shares and a warrant to purchase 4,134 shares of common stock
     exercisable within 60 days of September 30, 1999 held by Galen Partners
     International III, L.P. and
   . 6,544 shares and a warrant to purchase 187 shares of common stock
     exercisable within 60 days of September 30, 1999 held by Galen Employee
     Fund III, L.P.
   Dr. Wilkerson, a co-founder of Galen Associates and a director of Chemdex,
   disclaims beneficial ownership of the shares held by Galen Partners III,
   L.P., Galen Partners International III, L.P., and Galen Employee Fund III,
   L.P., except to the extent of his pecuniary interest therein arising from
   his general partnership interest in these funds.
 (6) All shares held by Mr. Samec are subject to repurchase by Chemdex within
     60 days of September 30, 1999 in the event of a termination of his
     employment with Chemdex.
 (7) Includes 17,656 shares held by Mr. Burke subject to repurchase by Chemdex
     within 60 days of September 30, 1999.
 (8) Includes:
   . 2,748,148 shares held by Kleiner Perkins Caufield & Byers VIII, L.P.
   . 153,014 shares held by KPCB Life Sciences Zaibatsu Fund II, L.P. and
   . 159,135 shares held by KPCB VIII Founders Fund, L.P.
   Mr. Byers, a Senior Partner of Kleiner Perkins Caufield & Byers, disclaims
   beneficial ownership of the shares held by Kleiner Perkins Caufield &
   Byers VIII, L.P., KPCB Life Sciences Zaibatsu Fund II, L.P. and KPCB VIII
   Founders Fund, L.P., except to the extent of his pecuniary interest
   therein arising from his general partnership interest in these funds.
 (9) Mr. Lewis, a director of Chemdex, is a managing director and member of
     E.M. Warburg, Pincus & Co., LLC, the manager of Warburg, Pincus Ventures
     L.P. Mr. Lewis may be deemed to have an indirect

                                      128
<PAGE>

    pecuniary interest (within the meaning of Rule 16a-1 of the Securities
    Exchange Act of 1934, as amended) in an indeterminate portion of the shares
    beneficially owned by Warburg, Pincus Ventures, L.P. Mr. Lewis disclaims
    beneficial ownership of all shares held by Warburg, Pincus entities.
(10) Excludes all but 6,867 of the 2,795,018 shares held by The Bay City
     Capital Fund I, L.P. Certain trusts for the benefit of the lineal
     descendants of Nicholas J. Pritzker, deceased (including Mr. Pritzker) are
     indirect investors in The Bay City Capital Fund I, L.P. Mr. Pritzker
     disclaims any beneficial ownership in the shares held by The Bay City
     Capital Fund I, L.P., except for 6,867 shares.
(11) Includes:
   . 2,702,657 shares held by CMG@Ventures II, LLC and
   . 25,700 shares held by Mr. Callaghan, a General Partner of CMG@Ventures
     and a director of Chemdex.
   Mr. Callaghan disclaims beneficial ownership of the shares held by
   CMG@Ventures II, LLC, except to the extent of his pecuniary interest
   therein arising from his general partnership interest in these funds.
(12) Includes 2,538,405 shares held by VWR Scientific Products Corporation, a
     company of which Mr. Harris is the President and Chief Executive Officer
     and 8,747 shares held by Mr. Harris. Mr. Harris disclaims beneficial
     ownership of the shares held by VWR Scientific Products Corporation,
     except to the extent of his pecuniary interest therein.
(13) Includes 1,799,473 shares held by entities affiliated with Galen
     Associates, an entity with which Dr. Wilkerson is affiliated. Dr.
     Wilkerson disclaims beneficial ownership of the shares held by entities
     affiliated with Galen Associates, except to the extent of his pecuniary
     interest therein arising from his general partnership interest in these
     funds.
(14) Includes 27,344 shares held by Mr. Swanson as trustee of an irrevocable
     trust and subject to repurchase by Chemdex within 60 days of September 30,
     1999 in the event of termination of his relationship with Chemdex. Also
     includes 624,166 shares held by a partnership affiliated with Mr. Swanson.

                                      129
<PAGE>

                      DESCRIPTION OF CHEMDEX CAPITAL STOCK

   As of the date of this document, the authorized capital stock of Chemdex
consists of 175,000,000 shares of common stock, $.0002 par value, and 2,500,000
shares of undesignated preferred stock, $.0002 par value. The following
description of Chemdex's capital stock is only a summary and may be more
completely understood by reading Chemdex's Certificate of Incorporation and
Bylaws and the provisions of applicable Delaware law.

Common Stock

   As of September 30, 1999, there were 32,775,335 shares of common stock
outstanding that were held of record by approximately 8,000 stockholders. Based
on the number of fully diluted shares of Promedix capital stock outstanding as
of September 30, 1999, there will be approximately 43,564,271 shares of common
stock outstanding after giving effect to the exchange of Promedix capital stock
for Chemdex common stock.

   Subject to preferences that may apply to shares of preferred stock
outstanding at the time, the holders of outstanding shares of common stock are
entitled to receive dividends out of assets legally available therefore at
times and in amounts as the Board of Directors may determine. Each stockholder
is entitled to one vote for each share of common stock held on all matters
submitted to a vote of the stockholders. Cumulative voting is not provided for
in Chemdex's amended and restated certificate of incorporation, which means
that the majority of the shares voted can elect all of the directors then
standing for election. The common stock is not entitled to preemptive rights
and is not subject to conversion or redemption. Upon the occurrence of a
liquidation, dissolution or winding-up, the holders of shares of common stock
are entitled to share ratably in all assets remaining after payment of
liabilities and satisfaction of preferential rights of any outstanding
preferred stock. There are no sinking fund provisions applicable to the common
stock. The outstanding shares of common stock are, and the shares of common
stock to be issued upon completion of this offering will be, fully paid and
non-assessable.

Preferred Stock

   The Board of Directors has the authority, within the limitations and
restrictions in the amended and restated certificate of incorporation, to issue
2,500,000 shares of preferred stock in one or more series and to fix the
rights, preferences, privileges and restrictions thereof, including dividend
rights, dividend rates, conversion rights, voting rights, terms of redemption,
redemption prices, liquidation preferences and the number of shares
constituting any series or the designation of any series, without further vote
or action by the stockholders. The issuance of preferred stock may have the
effect of delaying, deferring or preventing a change in control of Chemdex
without further action by the stockholders. The issuance of preferred stock
with voting and conversion rights may adversely affect the voting power of the
holders of common stock, including voting rights, of the holders of common
stock. In some circumstances, this issuance could have the effect of decreasing
the market price of the common stock. Chemdex currently has no plans to issue
any shares of preferred stock.

Options

   As of September 30, 1999, options to purchase a total of 2,034,352 shares of
Chemdex common stock were outstanding, and up to 1,862,690 additional shares of
common stock may be subject to options granted in the future under the 1998
Stock Plan.

Warrants

   As of September 30, 1999, Chemdex had the following outstanding warrants:
warrants to purchase a total of 49,999 shares of common stock at an exercise
price of $5.20 that are held by entities affiliated with Galen Associates; and
a warrant to purchase 105,000 shares of common stock at an exercise price of
$1.50 that is held by Comdisco, Inc. and a warrant to purchase 25,000 shares of
common stock by ALZA Corporation at an exercise price of $15.00. All of the
warrants contain standard anti-dilution provisions.

                                      130
<PAGE>

     COMPARISON OF RIGHTS OF CHEMDEX STOCKHOLDERS AND PROMEDIX STOCKHOLDERS

   The following is a summary comparison of the material differences between
the rights of a Promedix stockholder and a Chemdex stockholder arising from the
differences between the governing instruments of the two companies. The summary
is not a complete description of those laws or governing instruments. Copies of
Chemdex's Promedix's Amended and Restated Certificate of Incorporation and
Bylaws have been filed with the SEC and will be sent to holders of Promedix
common stock upon request. See "Where You Can Find More Information" on page  .

General

   Both Chemdex and Promedix are incorporated in the state of Delaware. If the
merger is consummated, holders of Promedix common stock and preferred stock
will become holders of Chemdex common stock and the rights of the former
Promedix stockholders will be governed by Chemdex's certificate of
incorporation and bylaws. The rights of Chemdex stockholders under Chemdex's
certificate of incorporation and bylaws differ in limited respects from the
rights of the Promedix stockholders under Promedix's certificate of
incorporation and bylaws. These differences are summarized below.

The Rights of Promedix Preferred Stockholders

   If the merger is consummated, holders of Promedix preferred stock will
become holders of Chemdex common stock. Under Promedix's certificate of
incorporation, the holders of Promedix preferred stock have the right to
receive a liquidation preference, the right to participate with the common
stock in receiving liquidating distributions and the right to convert to common
stock. The holders of Promedix Series A preferred stock are entitled to receive
a liquidation preference of $0.751 per share prior to distributions to any
other stockholder. The holders of Promedix series B-1 and Series B-2 preferred
stock are entitled to receive a liquidation preference of $1.50 per share.
Holders of the Promedix preferred stock will not receive their liquidation
preference in the merger and will instead participate with the common stock in
receiving distributions on an as converted basis. Holders of Chemdex common
stock have no preference rights and are treated equally in terms of liquidation
rights.

Blank Check Preferred

   The Chemdex certificate of incorporation permits the Chemdex board of
directors to determine the rights, preferences, privileges and restrictions of
authorized but unissued preferred stock, commonly referred to as "blank check"
preferred stock. The issuance of preferred stock with extraordinary rights may
be used to deter hostile takeover attempts. The Chemdex board could issue the
Chemdex preferred stock at any time in the future without stockholder approval.
The Promedix certificate of incorporation does not permit the Promedix board of
directors to issue "blank check" preferred stock and requires the approval of
the holders of Promedix preferred stock in order to issue any stock with
preferences or priorities superior to or on parity with the currently
outstanding Promedix preferred stock.

Capitalization

   Chemdex. Chemdex is authorized to issue 175,000,000 shares of common stock
and 2,500,000 shares of preferred stock. On September 30, 1999, approximately
32,775,335 shares of Chemdex common stock were outstanding and no shares of
Chemdex preferred stock were outstanding. Chemdex's board has the authority,
without stockholder approval, to issue shares of authorized preferred stock
from time to time in one or more series and to fix the rights and preferences,
including voting rights, of each series of preferred stock, which rights and
preferences may be superior to that of Chemdex's common stock.

                                      131
<PAGE>

   Promedix. Promedix is authorized to issue 15,500,000 shares of common stock,
4,500,000 shares of Series A preferred stock, 333,334 shares of Series B-1
preferred stock, and 346,020 shares of Series B-2 preferred stock. On the
record date,     shares of common stock, all of the authorized shares of Series
A preferred stock and none of the shares of Series B-1 preferred stock, or
Series B-2 preferred stock, were outstanding. In the event of a merger or
acquisition of Promedix, the holders of Series A preferred stock, Series B-1
preferred stock and Series B-2 preferred stock have the right to have their
shares of Promedix preferred stock redeemed by Promedix.

Voting Rights

   Each holder of Chemdex common stock is entitled to one vote for each share
and may not cumulate votes for the election of directors. However, holders of
Promedix common stock are entitled to one vote for each share. Moreover,
holders of Promedix Series A preferred stock, Series B-1 preferred stock and
Series B-2 preferred stock are entitled to vote together as a single class with
respect to some of the matters specifically set forth in Promedix's charter,
including mergers.

   Promedix is a Delaware corporation, and the rights of Promedix's
stockholders are governed by Promedix's Amended and Restated Certificate of
Incorporation and Bylaws and by Delaware law. Upon the consummation of the
merger, stockholders of Promedix will become stockholders of Chemdex and their
rights will be governed by Chemdex's Amended and Restated Certificate of
Incorporation and Bylaws and by Delaware law.

Future Stockholder Proposals

   Promedix does not currently expect to hold a 1999 Annual Meeting of
Stockholders because upon consummation of the merger Promedix will become an
indirect wholly-owned subsidiary of Chemdex. In the event the merger is not
consummated, proposals of Promedix stockholders to be included in the proxy
statement to be mailed to all Promedix stockholders entitled to vote at the
1999 Annual Meeting of Promedix stockholders must be received at Promedix's
principal executive offices not later than         , 1999.

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<PAGE>

                                    EXPERTS

   Ernst & Young LLP, independent auditors, have audited Chemdex's financial
statements as of December 31, 1997 and 1998, and for the period from September
4, 1997 (inception) through December 31, 1997 and for the year ended December
31, 1998, as set forth in their report. Chemdex's financial statements are
included in this joint proxy statement/prospectus and elsewhere in the
registration statement in reliance on Ernst & Young LLP's report, given on
their authority as experts in accounting and auditing.

   Ernst Young LLP, independent auditors, have audited Promedix's financial
statements as of December 31, 1997 and 1998 and for the years then ended, as
set forth in their report. Promedix's financial statements are included in this
joint proxy statement/prospectus and elsewhere in the registration statement in
reliance on Ernst & Young LLP's report, given on their authority as experts in
accounting and auditing.

   Jones, Jensen & Company, independent auditors, have audited Pro Med Co.'s
financial statements as of December 31, 1997 and 1998 and for the years then
ended, as set forth in their report. Pro Med Co.'s financial statements are
included in this joint proxy statement/prospectus and elsewhere in the
registration statement in reliance on Jones, Jensen & Company's report, given
on their authority as experts in accounting and auditing.

                       CHANGE IN INDEPENDENT ACCOUNTANTS

   Effective September 2, 1998, Ernst & Young LLP was engaged as Chemdex's
independent auditors and replaced other auditors who were dismissed as its
independent accountants on the same date. The decision to change auditors was
approved by Chemdex's Board of Directors on September 2, 1998. Prior to
September 2, 1998, Chemdex's former auditors issued a report on the period from
September 4, 1997 (inception) to December 31, 1997. The report of Chemdex's
former auditors did not contain an adverse opinion or disclaimer of opinion
qualified or modified as to any uncertainty, audit scope or accounting
principle. In connection with the audit for the period from September 4, 1997
(inception) through December 31, 1997 and through September 2, 1998, there were
no disagreements with Chemdex's former auditors on any matter of accounting
principles or practices, financial statement disclosure or auditing scope or
procedure, which disagreements if not resolved to the satisfaction of our
former auditors, would have caused them to make reference thereto in their
report on the financial statements for such period. Chemdex's former auditors
have not audited or reported on any of the financial statements or information
included in this prospectus. Prior to September 2, 1998, Chemdex had not
consulted with Ernst & Young LLP on items that involved Chemdex's accounting
principles or the form of audit opinion to be issued on our financial
statements.

                                 LEGAL MATTERS

   Certain legal matters with respect to the validity of the shares of Chemdex
common stock offered hereby and certain tax matters with respect to the merger
will be passed upon for Chemdex by Venture Law Group, A Professional
Corporation, Menlo Park, California. Jeffrey Y. Suto, a director of Venture Law
Group, is the Secretary of Chemdex. Certain other legal matters in connection
with the merger will be passed upon for Chemdex by Morrison & Foerster,
Washington, D.C. Certain matters with respect to the merger will be passed upon
for Promedix by Orrick, Herrington & Sutcliffe LLP, Menlo Park, California.
Employees of Venture Law Group and an investment partnership affiliated with
Venture Law Group own a total of 76,285 shares of Chemdex common stock,
including 16,792 shares held by Mr. Suto.

                                 OTHER MATTERS

   Neither the Chemdex board nor the Promedix board intends to bring any
matters before the meetings other than those specifically set forth in the
notices of meetings and neither knows of any matters to be brought before the
respective meetings by others. If any other matters properly come before the
meetings, it is the intention of the persons named in the accompanying proxies
to vote such proxies in accordance with the judgment of the Chemdex board or
the Promedix board, as applicable.

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<PAGE>

                ADDITIONAL MATTERS BEING SUBMITTED TO A VOTE OF
                           ONLY CHEMDEX STOCKHOLDERS

                             Chemdex Proposal No. 2

         Approval of Amendment to the 1999 Employee Stock Purchase Plan

   Holders of Chemdex common stock are also being asked to approve an amendment
to the 1999 Employee Stock Purchase Plan to provide for an increase in the
number of shares reserved for issuance thereunder by 300,000 shares of Common
Stock to an aggregate of 1,050,000, plus a previously approved automatic annual
increase on the first day of each of Chemdex's fiscal years in 2000, 2001,
2002, 2003 and 2004 equal to the lesser of 200,000 shares, .5% of the
outstanding Common Stock on the last day of the immediately preceding fiscal
year, or a lesser number determined by the board of directors. The new shares
being added to the plan will only be available for offering periods that
commence after the date of shareholder approval of the amendment. As of
September 30, 1999, 750,000 shares were available for future issuance under the
plan. The proposed amendment to the plan was approved by the board of directors
in November 1999, subject to stockholder approval at the special meeting.

   Chemdex implemented the plan in 1999 as an incentive to its employees and
executives as a means to promote increased stockholder value. The purpose of
the plan is to provide employees of Chemdex with an opportunity to purchase
common stock of Chemdex through accumulated payroll deductions. Management
believes that stock ownership is one of the prime methods of attracting and
retaining key personnel responsible for the continued development and growth of
Chemdex's business.

   The following is a summary of the principal provisions of the amended plan,
but it is not intended to be a complete description of all of the terms and
provisions of the plan. A copy of the plan will be furnished to any shareholder
upon written request to Chemdex's Chief Financial Officer at Chemdex's
principal executive offices in Mountain View, California.

Description of the 1999 Employee Stock Purchase Plan

   The plan was adopted by the board of directors in May 1999 and approved by
the stockholders in July 1999. A total of 750,000 shares of common stock was
initially reserved for issuance under the plan, plus an automatic annual
increase on the first day of each of Chemdex's fiscal years in 2000, 2001,
2002, 2003 and 2004 equal to the lesser of 200,000 shares or .5% of Chemdex's
outstanding common stock on the last day of the immediately preceding fiscal
year. No shares have been issued under the 1999 Employee Stock Purchase Plan as
of the date of this meeting.

   The plan, which is intended to qualify under Section 423 of the Internal
Revenue Code, is implemented by a series of offering periods of twenty-four
months duration. Each offering period commences on or about February 16 and
August 16 of each year. Each offering period generally consists of four
consecutive purchase periods of six months duration, with the last day of each
period being designated a purchase date. The first purchase date under the plan
will occur on February 15, 2000, with subsequent purchase dates to occur every
six months thereafter. The plan is administered by the board of directors.
Chemdex employees, including officers and employee directors, are eligible to
participate in the plan if they are employed by Chemdex (or a designated
subsidiary) for at least 20 hours per week and more than five months per year.
The plan permits eligible employees to purchase common stock through payroll
deductions, which may not exceed 20% nor equal less than 1% of an employee's
compensation, at a price equal to the lower of 85% of the fair market value of
Chemdex's common stock at the beginning of the offering period or the purchase
date. If the fair market value of the common stock on a purchase date is less
than the fair market value at the beginning of the offering period, a new
twenty-four month offering period will automatically begin on the first
business day following the purchase date with a new fair market value.
Employees may end their participation in the offering at any time during the
offering period, and participation ends automatically on termination of
employment with Chemdex. If not terminated earlier, the plan will have a term
of 20 years.

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<PAGE>

   The plan provides that in the event of the proposed dissolution or
liquidation of Chemdex, each offering period will terminate immediately prior
to the consummation of such proposed action, unless otherwise provided by the
board of directors. In the event of a merger of Chemdex with or into another
corporation or a sale of all or substantially all of Chemdex's assets, each
right to purchase stock under the plan will be assumed or an equivalent right
substituted by the successor corporation unless the board of directors shortens
each offering period and plan period then in progress so that employees' rights
to purchase stock under the plan are exercised prior to the merger or sale of
assets. The board of directors has the power to amend or terminate the plan as
long as such action does not adversely affect any outstanding rights to
purchase stock thereunder, provided that the board of directors can terminate
the plan or any offering period under the plan in the event that prevailing
accounting rules change in such a way that would have an adverse effect on
Chemdex if it did not terminate the plan or offering period. Stockholder
approval will be obtained for any plan amendment as required by applicable law.

Certain United States Federal Income Tax Information

   The following is a general summary as of the date of this proxy statement of
the United States federal income tax consequences associated with participation
in the plan. The federal tax laws may change and the federal, state and local
tax consequences for any participant will depend upon his or her individual
circumstances. All participants are advised to seek the advice of a tax advisor
regarding the tax consequences of participation in the plan.

   The plan is intended to qualify as an "employee stock purchase plan" within
the meaning of section 423 of the Internal Revenue Code. Under these
provisions, no income will be taxable to a participant at the time of grant of
the option or purchase of shares. A participant may become liable for tax upon
disposition of the shares acquired, as summarized below.

   If the shares are sold or disposed of (including by way of gift) more than
two years after the first day of the offering period during which shares were
purchased and more than one year after a purchase date. In this event, the
lesser of (a) the excess of the fair market value of the shares at the time of
such disposition over the purchase price of the shares subject to the option or
(b) 15% of the fair market value of the shares on the first day of the offering
period, will be treated as ordinary income to the participant. Any further gain
upon such disposition will be treated as long-term capital gain, taxable at a
maximum tax rate of 20%. If the shares are sold and the sale price is less than
the purchase price, no ordinary income is recognized and the participant has a
capital loss for the difference.

   If the shares are sold or disposed of (including by way of gift) before the
expiration of either of the holding periods described above. In this event,
referred to as a disqualifying disposition, the excess of the fair market value
of the shares on the purchase date over the option price will be treated as
ordinary income to the participant. This excess will constitute ordinary income
in the year of sale or other disposition even if no gain is realized on the
sale or a gift of the shares is made. The balance of any gain will be treated
as capital gain and will be treated as long-term capital gain if the shares
have been held more than one year. Even if the amount realized upon disposition
of the shares is less than their fair market value on the purchase date, the
same amount of ordinary income is attributed to a participant and a capital
loss is recognized equal to the difference between the sales price and the
value of the shares on such purchase date.

   The ordinary income reported under the rules described above, added to the
actual purchase price of the shares, determines the tax basis of the shares for
the purpose of determining capital gain or loss on a sale or exchange of the
shares.

   Tax Treatment of Chemdex. The Company will be entitled to a deduction for
federal income tax purposes to the extent that a participant recognizes
ordinary income on a disqualifying disposition of the shares, but not if a
participant meets the holding period requirements.

Recommendation of the Chemdex Board of Directors:

   THE CHEMDEX BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE APPROVAL OF THE
AMENDMENT TO THE 1999 EMPLOYEE STOCK PURCHASE PLAN.

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<PAGE>

                             Chemdex Proposal No. 3

                  Approval of Amendment to the 1998 Stock Plan

   Holders of Chemdex common stock are also being asked to approve an amendment
to the Chemdex 1998 Stock Plan to increase the number of shares of common stock
reserved for issuance under the plan by 4,250,000 shares to an aggregate of
10,375,000, plus a previously approved automatic annual increase on the first
day of each of Chemdex's fiscal years in 2000, 2001, 2002, 2003 and 2004 equal
to the lesser of 1,250,000 shares or 3% of the shares outstanding on the last
day of the immediately preceding fiscal year. The board of directors adopted
the amendment in October 1999, subject to stockholder approval at the
meeting.

   Chemdex believes that long-term equity compensation in the form of stock
options and stock purchase rights is critical in order to attract qualified
employees to Chemdex and to retain and provide incentives to current employees,
particularly in light of the increasingly competitive environment for talented
personnel. As of September 30, 1999, options to purchase 2,034,352 shares were
outstanding under the plan, 2,533,315 shares had been issued pursuant to the
exercise of options or stock purchase rights granted under the plan and
1,862,690 shares remained available for future grants. The board of directors
believes that the number of shares currently available under the plan is likely
to be insufficient in light of potential continued growth in Chemdex's
operations, including potential increases in the number of employees if and to
the extent Chemdex completes acquisitions of other companies or businesses. For
this reason, the board of directors has determined that it is in the best
interests of Chemdex to increase the number of shares available for issuance
under the plan by     shares.

   The following is a summary of the principal features of the plan, but it is
not intended to be a detailed description of all of the terms and provisions of
the plan. A copy of the plan will be furnished to any shareholder upon written
request to Chemdex's Chief Financial Officer at Chemdex's principal executive
offices in Mountain View, California.

Description of the 1998 Stock Option Plan

   The plan was originally adopted by the board of directors in January 1998
and approved by the stockholders in March 1998. A total of 1,000,000 shares of
common stock was initially reserved for issuance under the plan. In April and
May 1999, the board of directors and the stockholders approved amendments to
the plan, that among other things, increased the number of shares reserved for
issuance under the plan by 2,750,000 shares, plus an automatic annual increase
on the first day of each of Chemdex's fiscal years in 2000, 2001, 2002, 2003
and 2004 equal to the lesser of 1,250,000 shares, 3% of the shares outstanding
on the last day of the immediately preceding fiscal year or a lesser number
determined by the board of directors.

   The plan is not a tax-qualified deferred compensation plan under Section
401(a) of the Code, and is not subject to the provisions of the Employee
Retirement Income Security Act of 1974, as amended.

   As of September 30, 1999, Chemdex's current executive officers received
grants under the plan of options or stock purchase rights to purchase 1,622,500
shares of common stock of Chemdex (8 persons); 133,861 option or stock purchase
right grants were made to Chemdex's current directors who are not executive
officers (5 persons); and all other Chemdex employees, including current
officers who are not executive officers, received grants of options or stock
purchase rights to purchase 2,956,956 shares of common stock (172 persons).

   The plan is administered by the board of directors or by a committee of the
board of directors. The plan is currently being administered by the
compensation committee of the board of directors. The compensation committee
has the exclusive authority to grant stock options and otherwise administer the
plan with respect to the officers and directors.

                                      136
<PAGE>

   The plan provides that either incentive stock options or nonstatutory stock
options may be granted to employees (including officers and directors) of
Chemdex or any of its subsidiaries. In addition, the plan provides that
nonstatutory stock options may be granted to consultants (including directors
who are not employees of Chemdex) or any of its subsidiaries. The board of
directors may also issue stock purchase rights under the plan to employees,
directors and consultants.

   The board of directors or the compensation committee selects the optionees
and determines the number of shares to be subject to each option or stock
purchase right. In making such determination, a number of factors are taken
into account, including the duties and responsibilities of the optionee, the
value of the optionee's services to Chemdex, the optionee's present and
potential contribution to the success of the Company, and other relevant
factors. As of September 30, 1999, there were approximately 186 employees,
officers, consultants and directors eligible to receive grants under the plan.

   The plan provides that the maximum number of shares of common stock which
may be granted under options and stock purchase rights to any one employee
during any fiscal year is 10,000,000, subject to adjustment as provided in the
plan. There is also a limit on the aggregate market value of shares subject to
all incentive stock options that may be granted to an optionee during any
calendar year.

   Each stock award is evidenced by an agreement between Chemdex and the
optionee which contains terms and conditions not inconsistent with the plan as
determined by the board of directors or its committee.

   In the event any change, such as a stock split or dividend, is made in
Chemdex's capitalization that results in an increase or decrease in the number
of outstanding shares of common stock without receipt of consideration by
Chemdex, appropriate adjustment shall be made in the exercise price of each
outstanding option and stock purchase right, the number of shares subject to
each option, the annual limitation on grants to employees, as well as the
number of shares available for issuance under the plan. In the event of the
proposed dissolution or liquidation of Chemdex, each option or stock purchase
right will terminate unless otherwise provided by the board of directors or its
committee. In the event of a merger of Chemdex with or into another corporation
or a sale of all or substantially all of Chemdex's assets, each option or stock
purchase right will be assumed or an equivalent right substituted by the
successor corporation unless the successor corporation refuses to do an
assumption or substitution, in which case each option and stock purchase right
shall terminate upon completion of the transaction. The board of directors has
the power to amend or terminate the plan as long as such action does not
adversely affect any outstanding options or stock purchase rights. Stockholder
approval of plan amendments will be obtained as required by applicable law.

Certain United States Federal Income Tax Information

   Options granted under the plan may be either "incentive stock options," as
defined in Section 422 of the Internal Revenue Code, or nonstatutory stock
options.

   The recipient of an incentive stock option does not incur ordinary taxable
income at the time of grant or exercise of the option. However, the optionee
may incur alternative minimum tax upon exercise of the option. Chemdex is not
entitled to a tax deduction at the time of exercise of an incentive stock
option regardless of the applicability of the alternative minimum tax. Upon the
sale or exchange of the shares at least one year after exercise of the option
by the optionee and two years after grant of the incentive stock option, any
gain is treated as long-term capital gain. If these holding periods are not
satisfied, the optionee recognizes ordinary taxable income equal to the
difference between the exercise price, and the lower of the fair market value
of the stock at the date of the option exercise or the sale price of the stock.
Any gain to the optionee in excess of the ordinary income from a disposition
which does not meet the statutory holding period requirements, is long-term
capital gain if the sale occurs more than one year after exercise or short-term
capital gain if the sale occurs less than one year after the exercise. The
current federal tax rate on long-term capital gain is capped at 20%.

   Options which do not qualify as incentive stock options are nonstatutory
stock options. An optionee does not recognize taxable income at the time of
grant of a nonstatutory stock option. However, upon exercise, the

                                      137
<PAGE>

optionee does recognize ordinary taxable income equal to the excess of the fair
market value of the shares at time of exercise over the exercise price. The
income recognized by an optionee who is also an employee of Chemdex is subject
to income tax withholding. Chemdex is entitled to a tax deduction for the
amount of the ordinary income recognized by the optionee. Upon resale of such
shares by the optionee, any difference between the sale price and the
optionee's tax basis (exercise price plus the income recognized upon exercise)
is treated as capital gain or loss.

   Stock purchase rights are generally taxed in the same manner as nonstatutory
stock options. A purchaser will generally recognize ordinary taxable income
equal to the excess of the fair market value of the shares at time of purchase
over the purchase price. In the event that the shares are subject to repurchase
by Chemdex at the purchaser's original purchase price (vesting), the timing of
recognition of the taxable income is deferred until the date of vesting, unless
the purchaser elects to accelerate the income recognition to the purchase date.
The income recognized by an optionee who is also an employee of Chemdex is
subject to income tax withholding. Chemdex is entitled to a tax deduction for
the amount of the ordinary income recognized by the purchaser. Upon resale of
such shares by the optionee, any difference between the sale price and the
purchaser's tax basis (exercise price plus the income recognized upon purchase
or vesting, as applicable) is treated as capital gain or loss.

Recommendation of the Chemdex Board of Directors:

   THE CHEMDEX BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE APPROVAL OF THE
AMENDMENT TO THE 1998 STOCK OPTION PLAN AS DESCRIBED ABOVE.

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<PAGE>

                      WHERE YOU CAN FIND MORE INFORMATION

   Chemdex files reports, proxy statements and other information with the
Securities and Exchange Commission. Copies of these reports, proxy statements
and other information may be inspected and copied at the public reference
facilities maintained by the Securities and Exchange Commission:

<TABLE>
<S>                        <C>                           <C>
Judiciary Plaza            Citicorp Center               Seven World Trade Center
450 Fifth Street, N.W.     500 West Madison Street       13th Floor
Room 1024                  Suite 1400                    New York, New York 10048
Washington, D.C. 20549     Chicago, Illinois 60661
</TABLE>

   Copies of these materials can also be obtained by mail at prescribed rates
from the Public Reference Section of the Securities and Exchange Commission,
450 Fifth Street, N.W., Washington, D.C. 20549 or by calling the Securities and
Exchange Commission at 1-800-SEC-0330. The Securities and Exchange Commission
maintains a website that contains reports, proxy statements and other
information regarding each of us. The address of the Securities and Exchange
Commission website is http://www.sec.gov.

   Chemdex has filed a registration statement under the Securities Act with the
Securities and Exchange Commission with respect to Chemdex's common stock to be
issued to Promedix stockholders in the merger. This proxy statement and
prospectus constitutes the prospectus of Chemdex filed as part of the
registration statement. This proxy statement and prospectus does not contain
all of the information set forth in the registration statement because certain
parts of the registration statement are omitted as provided by the rules and
regulations of the Securities and Exchange Commission. You may inspect and copy
the registration statement at any of the addresses listed above.

   YOU SHOULD RELY ONLY ON THE INFORMATION CONTAINED IN THIS PROXY STATEMENT
AND PROSPECTUS TO VOTE ON THE APPROVAL OF THE MERGER AGREEMENT. NEITHER CHEMDEX
NOR PROMEDIX HAS AUTHORIZED ANYONE TO PROVIDE YOU WITH INFORMATION THAT IS
DIFFERENT FROM WHAT IS CONTAINED IN THIS PROXY STATEMENT AND PROSPECTUS.
NEITHER THE DELIVERY OF THIS PROXY STATEMENT AND PROSPECTUS NOR ANY
DISTRIBUTION OF SECURITIES MEANS, UNDER ANY CIRCUMSTANCES, THAT THERE HAS BEEN
NO CHANGE IN THE INFORMATION SET FORTH OR INCORPORATED IN THIS DOCUMENT BY
REFERENCE OR IN OUR AFFAIRS SINCE THE DATE OF THIS PROXY STATEMENT AND
PROSPECTUS. THE INFORMATION CONTAINED IN THIS DOCUMENT WITH RESPECT TO CHEMDEX
AND ITS SUBSIDIARY WAS PROVIDED BY CHEMDEX; THE INFORMATION CONTAINED IN THIS
DOCUMENT WITH RESPECT TO PROMEDIX WAS PROVIDED BY PROMEDIX.

                                      139
<PAGE>

                              CHEMDEX CORPORATION

                         INDEX TO FINANCIAL STATEMENTS

<TABLE>
<S>                                                                         <C>
Introductory Note to Financial Statements..................................  F-2

Chemdex Condensed Unaudited Interim Financial Statements

  Condensed Unaudited Balance Sheet........................................  F-3

  Condensed Unaudited Interim Statements of Operations.....................  F-4

  Condensed Unaudited Interim Statements of Cash Flows.....................  F-5

  Notes to Condensed Unaudited Interim Financial Statements................  F-6

Chemdex Financial Statements

  Report of Ernst & Young LLP, Independent Auditors........................ F-12

  Balance Sheets........................................................... F-13

  Statements of Operations................................................. F-14

  Statements of Stockholders' Equity....................................... F-15

  Statements of Cash Flows................................................. F-16

  Notes to Financial Statements............................................ F-17
</TABLE>

                                      F-1
<PAGE>

                   INTRODUCTORY NOTE TO FINANCIAL STATEMENTS

   Pages F-3 through F-28 include the Chemdex Corporation's condensed unaudited
interim financial statements from Chemdex's Quarterly Report on Form 10-Q as of
and for the quarterly period September 30, 1999 and Chemdex's financial
statements from Form S-1 that became effective on July 26, 1999.

                                      F-2
<PAGE>

                              CHEMDEX CORPORATION

                            CONDENSED BALANCE SHEETS

<TABLE>
<CAPTION>
                                                     September 30,  December 31,
                                                         1999         1998(1)
                                                     -------------  ------------
                                                      (Unaudited)
<S>                                                  <C>            <C>
Assets
Current assets:
  Cash and cash equivalents......................... $125,562,779   $ 5,990,188
  Accounts receivable, net of allowances of $664,000
   at September 30, 1999, and $2,000 at December 31,
   1998 ............................................    3,629,144        32,259
  Other current assets..............................    3,713,512       286,991
                                                     ------------   -----------
    Total current assets............................  132,905,435     6,309,438
Property and equipment, net.........................    7,212,190     1,558,245
Intangible and other assets.........................   14,677,676       300,472
                                                     ------------   -----------
    Total assets.................................... $154,795,301   $ 8,168,155
                                                     ============   ===========
Liabilities and stockholders' equity
Current liabilities:
  Accounts payable.................................. $  4,426,404   $   543,141
  Accrued compensation..............................    2,475,442       511,578
  Other accrued liabilities.........................    7,711,635       759,654
Current obligations under capital lease.............          --          5,425
Current portion of notes payable....................      379,059           --
                                                     ------------   -----------
    Total current liabilities.......................   14,992,540     1,819,798
Notes payable, less current portion.................      590,234           --
Stockholders' equity:
  Convertible preferred stock.......................          --          2,289
  Common stock......................................        6,565           784
  Additional paid-in capital........................  189,384,576    18,378,907
  Deferred compensation.............................   (6,926,489)   (2,992,099)
  Notes receivable from stockholders................   (1,047,047)     (149,717)
  Accumulated deficit...............................  (42,205,078)   (8,891,807)
                                                     ------------   -----------
    Total stockholders' equity......................  139,212,527     6,348,357
                                                     ------------   -----------
  Total liabilities and stockholders' equity........ $154,795,301   $ 8,168,155
                                                     ============   ===========
</TABLE>
- --------
(1) Derived from audited financial statements

          See accompanying notes to the Condensed Financial Statements

                                      F-3
<PAGE>

                              CHEMDEX CORPORATION

                       CONDENSED STATEMENTS OF OPERATIONS
                                  (Unaudited)

<TABLE>
<CAPTION>
                             Three Months Ended         Nine Months Ended
                               September 30,              September 30,
                          -------------------------  -------------------------
                              1999         1998          1999         1998
                          ------------  -----------  ------------  -----------
<S>                       <C>           <C>          <C>           <C>
Net revenues............. $  8,490,175  $       --   $ 11,561,238  $     3,500
Cost of revenues.........    8,085,761          --     10,994,266          --
                          ------------  -----------  ------------  -----------
    Gross profit.........      404,414          --        566,972        3,500
Operating expenses:
  Research and
   development...........    5,642,968    1,025,426    11,397,939    1,804,793
  Sales and marketing....    6,903,236      710,127    15,315,708    1,226,075
  General and
   administrative........    2,571,806      489,107     7,198,047    1,101,093
  Amortization of
   deferred
   compensation..........      546,507      103,841     1,445,305      169,859
                          ------------  -----------  ------------  -----------
    Total operating
     expenses............   15,664,517    2,328,501    35,356,999    4,301,820
                          ------------  -----------  ------------  -----------
Operating loss...........  (15,260,103)  (2,328,501)  (34,790,027)  (4,298,320)
Interest expense.........      (60,361)         --       (107,995)      (1,247)
Interest income and
 other, net..............    1,320,902      135,834     1,584,751      209,110
                          ------------  -----------  ------------  -----------
Net loss................. $(13,999,562) $(2,192,667) $(33,313,271) $(4,090,457)
                          ============  ===========  ============  ===========
Basic and diluted net
 loss per share.......... $       (.59) $     (1.21) $      (3.33) $     (2.37)
                          ============  ===========  ============  ===========
Weighted average shares
 of common stock used in
 computing basic and
 diluted net loss per
 share...................   23,639,711    1,816,701    10,007,174    1,723,549
</TABLE>



          See accompanying notes to the Condensed Financial Statements

                                      F-4
<PAGE>

                              CHEMDEX CORPORATION

                       CONDENSED STATEMENTS OF CASH FLOWS
                                  (Unaudited)

<TABLE>
<CAPTION>
                                                       Nine Months Ended
                                                         September 30,
                                                    -------------------------
                                                        1999         1998
                                                    ------------  -----------
<S>                                                 <C>           <C>
Operating Activities
Net loss........................................... $(33,313,271) $(4,090,457)
Adjustments to reconcile net loss to net cash used
 in operating activities:
  Depreciation and amortization....................    1,149,337      150,861
  Amortization of deferred compensation............    1,445,305      169,859
  Amortization of intangible asset.................    1,812,965          --
  Interest expense related to warrants.............       79,785          --
  Issuance of common stock for services............      262,641          --
  Loss on sale of equipment........................          --        10,559
  Issuance of warrants for rent expense............      375,000          --
Changes in operating assets and liabilities:
  Accounts receivable..............................   (3,596,885)     (27,150)
  Other current assets.............................   (3,528,315)    (222,812)
  Other assets.....................................       84,349     (158,108)
  Accounts payable.................................    3,883,263     (112,594)
  Accrued compensation.............................    1,963,864      177,385
  Other accrued liabilities........................    6,949,989       36,727
                                                    ------------  -----------
Net cash used in operating activities..............  (22,431,973)  (4,065,730)
                                                    ------------  -----------
Investing Activities
Purchases of property and equipment................   (5,671,421)  (1,055,442)
Purchases of short-term investments................          --    (6,593,495)
Proceeds from sale of equipment....................          --        36,991
                                                    ------------  -----------
Net cash used in investing activities..............   (5,671,421)  (7,611,946)
                                                    ------------  -----------
Financing Activities
Principal payments on capital lease obligations....       (5,425)      (5,704)
Principal payments on notes payable................     (162,568)         --
Net proceeds from issuance of preferred stock......   30,197,844   12,975,424
Net proceeds from issuance of common stock.........  117,639,451       10,258
Repurchase of common stock.........................       (3,170)         --
Repurchase of fractional shares....................         (870)         --
Payments of stockholders' notes receivable.........       10,723          (12)
                                                    ------------  -----------
Net cash provided by financing activities..........  147,675,985   12,979,966
                                                    ------------  -----------
Net increase in cash and cash equivalents..........  119,572,591    1,302,290
Cash and cash equivalents at beginning of period...    5,990,188    1,346,478
                                                    ------------  -----------
Cash and cash equivalents at end of period......... $125,562,779  $ 2,648,768
                                                    ============  ===========
Supplemental disclosure of noncash activities:
Issuance of shares in exchange for stockholders'
 notes receivable.................................. $    956,964  $    91,568
Repurchase of common stock issued in exchange for
 stockholders' notes receivable.................... $    (30,765) $       --
Equipment purchased under notes payable............ $  1,131,861  $       --
Issuance of common stock for intangible asset...... $ 13,910,459  $       --
Issuance of shares for services provided........... $  1,781,250  $       --
Issuance of warrants for services.................. $    526,427  $       --
Conversion of preferred to common shares........... $      3,349  $       --
Payments on notes receivable....................... $     18,146  $       --
</TABLE>

          See accompanying notes to the Condensed Financial Statements

                                      F-5
<PAGE>

                              CHEMDEX CORPORATION

              NOTES TO CONDENSED FINANCIAL STATEMENTS (Unaudited)

Note 1. Description of Business

   Chemdex Corporation is a provider of e-commerce solutions to the life
sciences research products market. Chemdex enables life sciences enterprises,
researchers, and suppliers to efficiently buy and sell research products
through the Chemdex Marketplace, a secure, Internet-based purchasing solution.

   Chemdex was incorporated in Delaware on September 4, 1997. During the period
from inception through November 1998, Chemdex was a development stage company
and did not have significant sales. During this period, operating activities
related primarily to the design and development of the Chemdex online
Marketplace, building corporate infrastructure and the establishment of
relationships with suppliers and customers. In November 1998, the Company
released its on-line marketplace to certain customers and recently, the Company
has entered into an agreement with VWR under which Chemdex recognizes revenue
related to certain sales from their joint web site. These sales, combined with
increased sales from the Chemdex online marketplace have led to a significant
increase in sales for the three and nine months ended September 30, 1999.
Chemdex has incurred operating losses to date and had an accumulated deficit of
approximately $42.2 million at September 30, 1999. Prior to the Company's
initial public offering in July 1999, Chemdex's activities had been primarily
financed through sales of equity securities.

   On July 27, 1999, the Company completed an initial public offering in which
it sold 7,500,000 shares of Common Stock at $15.00 per share. On August 17,
1999, the underwriters' exercised their over-allotment option for and
additional 1,125,000 shares. The Company received $117.6 million in net
proceeds, net of underwriting discounts, commissions and other offering costs.
Upon the closing of the offering, all of the Company's preferred stock, par
value $.0002 per share, automatically converted into an aggregate of 16,745,593
shares of Common Stock.

Note 2. Summary of Significant Accounting Policies

 Use of Estimates

   The preparation of financial statements in conformity with general
accounting principles requires management to make estimates and assumptions
that affect the amounts reported in the financial statements and accompanying
notes. Actual results could differ from those estimates.

 Revenue Recognition

   Net revenues consist primarily of product sales to customers and charges to
customers for outbound freight. Under most supplier agreements, Chemdex acts as
a principal when purchasing products from suppliers and reselling them to
customers. Products are shipped directly to customers by suppliers based on
customer delivery date specifications. Under principal-based agreements,
Chemdex is responsible for selling products, collecting payment from customers,
ensuring that the shipment reaches the customers and processing returns. In
addition, Chemdex takes title to products upon shipment and bears the risk of
loss for collection, delivery, and product returns from customers. Chemdex
provides an allowance for sales returns, which has been insignificant to date,
at the time of sale. Chemdex recognizes revenues from product sales when
products are shipped to customers.

   To date, an insignificant amount of revenue is from agreements with
suppliers for which Chemdex is acting as an agent. Under agency-based supplier
agreements, Chemdex recognizes a percentage share of revenues generated by
suppliers when products are shipped to customers.

                                      F-6
<PAGE>

                              CHEMDEX CORPORATION

        NOTES TO CONDENSED FINANCIAL STATEMENTS (Unaudited)--(Continued)


   Sales to four significant customers accounted for approximately 16%, 32%,
15%, and 11% respectively, of our revenues in the quarter ended September 30,
1999, and we currently expect to continue to derive a significant portion of
our revenues from these customers for the foreseeable future.

Note 3. Basis of Presentation

   The accompanying unaudited condensed financial statements have been prepared
by the Company in accordance with generally accepted accounting principles for
interim financial information and with the instructions to Form 10-Q and
Article 10 of Regulation S-X. Accordingly, they do not include all of the
information and footnotes required by generally accepted accounting principles
for complete financial statements. In the opinion of management, all
adjustments (all of which are normal and recurring in nature), considered
necessary for a fair presentation, have been included in the accompanying
unaudited financial statements. Operating results for the nine months ended
September 30, 1999 are not necessarily indicative of the results that may be
expected for the full year ending December 31, 1999. For further information,
refer to the financial statements and notes thereto, included in the Company's
Registration Statement on Form S-1 (File Number 333-78505), as amended, and the
Company's final prospectus filed July 28, 1999.

Note 4. Net Loss Per Share

   Net loss per share is presented in accordance with the requirements of
Statement of Financial Accounting Standards No. 128 "Earnings Per Share" (FAS
128) which requires dual presentation of basic earnings per share ("EPS") and
diluted EPS.

   Basic earnings per share is computed using the weighted average number of
common shares outstanding during the period. Diluted earnings per share is
computed using the weighted average number of common shares and potentially
dilutive shares outstanding during the period. If Chemdex had reported net
income, diluted earnings per share would have included the shares used in the
computation of basic net loss per share as well as an additional 1.5 million
common equivalent shares related to the outstanding options and warrants
(determined using the treasury stock method) for the three months ended
September 30, 1999. These options and warrants could potentially dilute basic
earnings per share in the future but have not been included in the computation
of diluted net loss per share as the impact would have been antidilutive for
the periods presented.

   Pro forma net loss per share is computed using the weighted average number
of shares of common stock outstanding, including common equivalent shares from
the convertible preferred stock (using the if-converted method), which
automatically converted into common stock upon the completion of the initial
public offering as if converted at the original date of issuance, for both
basic and diluted net loss per share, even though inclusion is antidilutive.

   The following table presents the reconciliation between basic and diluted
weighted average shares outstanding and those used for the pro forma net loss
per share calculation:

<TABLE>
<CAPTION>
                                       Three Months Ended    Nine Months Ended
                                          September 30,        September 30,
                                      --------------------- --------------------
                                         1999       1998       1999      1998
                                      ---------- ---------- ---------- ---------
<S>                                   <C>        <C>        <C>        <C>
Weighted-average shares outstanding,
 basic and diluted..................  23,639,711  1,816,701 10,007,174 1,723,549
Weighted-average conversion of
 convertible preferred stock on an
 if-converted basis.................   4,732,466 11,445,649 11,057,677 6,989,202
                                      ---------- ---------- ---------- ---------
Weighted-average shares used in pro
 forma calculation..................  28,372,177 13,262,350 21,064,851 8,712,751
                                      ========== ========== ========== =========
</TABLE>

                                      F-7
<PAGE>

                              CHEMDEX CORPORATION

        NOTES TO CONDENSED FINANCIAL STATEMENTS (Unaudited)--(Continued)


   The following table sets forth the computation of loss per share:

<TABLE>
<CAPTION>
                               Three Months Ended         Nine Months Ended
                                 September 30,              September 30,
                            -------------------------  -------------------------
                                1999         1998          1999         1998
                            ------------  -----------  ------------  -----------
   <S>                      <C>           <C>          <C>           <C>
   Basic and Diluted net
    loss per share
   Numerator: Net loss..... $(13,999,562) $(2,192,667) $(33,313,271) $(4,090,457)
   Denominator: Weighted-
    average shares
    outstanding basic and
    diluted................   23,639,711    1,816,701    10,007,174    1,723,549
                            ------------  -----------  ------------  -----------
   Basic and diluted net
    loss per share......... $       (.59) $     (1.21) $      (3.33) $     (2.37)
                            ============  ===========  ============  ===========
   Pro forma net loss per
    share
   Numerator: Net loss..... $(13,999,562) $(2,192,667) $(33,313,271) $(4,090,457)
   Denominator: Weighted-
    average shares
    outstanding basic and
    diluted................   28,372,177   13,262,350    21,064,851    8,712,751
                            ------------  -----------  ------------  -----------
   Basic and diluted pro
    forma net loss per
    share.................. $       (.49) $      (.17) $      (1.58) $      (.47)
                            ============  ===========  ============  ===========
</TABLE>

Note 5. Agreement with VWR

   In March 1999, Chemdex entered into a strategic relationship agreement with
VWR, which was consummated in April 1999, pursuant to which Chemdex and VWR
agreed to market jointly VWR laboratory products using the Chemdex Marketplace.
The term of the agreement is four years.

   The agreement gives Chemdex the right to offer approximately 350,000 VWR-
distributed products to Chemdex customers and both parties agreed to jointly
develop an online purchasing solution for VWR's existing customers. In
connection with the strategic relationship agreement, VWR transferred to
Chemdex information concerning VWR customers who purchased products from third
party suppliers outside VWR's primary product offering and Chemdex issued
2,538,405 shares of common stock valued at $13.9 million to VWR. The Company
intends to use this information to expand sales of its purchasing solution to
these customers and facilitate adoption of the Chemdex Marketplace by these
customers and suppliers. The fair value of the common stock of $13.9 million
was allocated to the customer list and is being amortized into sales and
marketing expense over four years, the estimated useful life of the intangible
asset.

Note 6. Agreement with Biotechnology Industry Organization

   In May 1999, the Biotechnology Industry Organization (BIO) selected Chemdex
as its preferred supplier of e-commerce purchasing solutions. As a result, the
Company entered into a five-year, exclusive joint marketing agreement with BIO.
As part of the joint marketing agreement, Chemdex will discount the fees it
charges to BIO members for its solution and will contribute cash payments to a
joint marketing fund, to be used in conjunction with both parties' obligations
under the joint marketing agreement. In addition, the Company sold 187,500
shares of its common stock to BIO for a nominal amount in consideration for
BIO's participation in these joint marketing activities. BIO has the right to
use a portion of the cash payments and any proceeds it receives from the sale
of the common stock for the benefit of its members and the biotechnology
industry. The charge for BIO marketing activities will be expensed to sales and
marketing as they are incurred. The Company recorded the difference between the
nominal amount per share price paid by BIO for the purchase of our common stock
and the fair value as of May 11, 1999, which is approximately $1.8 million as
an intangible asset, which is being amortized ratably over the five-year term
of the joint agreement.


                                      F-8
<PAGE>

                              CHEMDEX CORPORATION

        NOTES TO CONDENSED FINANCIAL STATEMENTS (Unaudited)--(Continued)

Note 7. Intangible and Other Assets

   Intangible and other assets are comprised of the following:

<TABLE>
<CAPTION>
                                          September 30, 1999 December 31, 1998
                                          ------------------ -----------------
   <S>                                    <C>                <C>
   Deposits and other....................    $   613,099         $300,472
   VWR related intangible, net of
    amortization.........................     12,461,453              --
   BIO related intangible, net, of
    amortization.........................      1,603,124              --
                                             -----------         --------
   Total intangible and other assets.....    $14,677,676         $300,472
                                             ===========         ========
</TABLE>

Note 8. Investments

   The Company considers all highly liquid investment securities with original
maturities of three months or less to be cash equivalents. Management
determines the appropriate classification of debt and equity securities at the
time of purchase and reevaluates such designation as of each balance sheet
date. To date, all marketable securities have been classified as available-for-
sale and are carried at fair value with material unrealized gains and losses,
if any, included in stockholders' equity. Realized gains and losses on
available-for-sale securities are included in interest income.

Note 9. Deferred Stock-Based Compensation

   We have recorded deferred compensation for options granted in fiscal year
1998 and the nine months ended September 30, 1999 for the difference at the
option grant date between the exercise price and the fair value of the common
stock underlying the options in accordance with Financial Accounting Standards
Board (FASB) Interpretation No. 28. As of September 30, 1999 we had recorded
aggregate deferred stock compensation of $8.7 million. The deferred stock
compensation is being amortized over the vesting periods of the stock options.
We recognized a total of $.4 million and $1.4 million in stock compensation
expense during 1998 and the nine months ended September 30, 1999, respectively.
The total charges to be recognized in future periods from amortization of
deferred stock compensation as of September 30, 1999 are anticipated to be
approximately $.6 million, $2.2 million, $2.2 million, $1.8 million and $.1
million for the remaining three months of 1999 and for 2000, 2001, 2002 and
2003, respectively.

Note 10. Segment Reporting

   During the year ended December 31, 1998 we adopted Statement of Financial
Accounting Standards No. 131, "Disclosures about Segments of an Enterprise and
Related Information" which establishes standards for reporting information
regarding operating segments in annual financial statements and requires
selected information for those segments to be presented in interim financial
statements. For all periods presented, we have viewed our operations as
principally one segment. All of the financial information presented represents
information for our principal operating segment.

Note 11. Commitments and Contingencies

   On August 14, 1999, we entered into two leases for our future headquarters
in Mountain View, California. The first lease, commencing in October 1999, is
for 5.4 years, with aggregate payments under the lease totaling $15.5 million.
The second lease commences on February 1, 2000 and is for a term of 5.1 years.
The aggregate payments under the second lease total $4.9 million. We plan to
move to our new headquarters during the fourth quarter. We have signed a sub-
lease for our existing offices for the remainder of our original lease term.
During the third quarter, we entered into a 2.4 year financing arrangement for
our insurance expenses, payments under this arrangement total $1.0 million to
be paid in 29 equal monthly installments. Future minimum lease payments under
non-cancelable operating leases entered during the quarter ended September 30,
1999 are $.5 million in 1999, $3.9 million in 2000, $4.2 million in 2001, $3.9
million in 2002, $4.0 million in 2003, $4.1 million in 2004, and $.7 million
thereafter.


                                      F-9
<PAGE>

                              CHEMDEX CORPORATION

        NOTES TO CONDENSED FINANCIAL STATEMENTS (Unaudited)--(Continued)

Note 12. Related Party Transactions

   VWR's former president and Chief Executive Officer is a director of the
Company. In addition, VWR owns 2,538,405 shares of our common stock. VWR and
Chemdex jointly market VWR core products and Chemdex core products to VWR's
existing and new customers and jointly solicit several key existing VWR
suppliers to distribute, market and sell their products through the Chemdex
Marketplace. VWR currently performs some of the billing and cash collection
functions for the sale of jointly marketed products until these functions can
be transitioned to Chemdex. With respect to sales of VWR core products, we act
as an intermediary and forward orders received through the Chemdex Marketplace
to VWR for fulfillment and customer service. We receive no fee for orders for
VWR core products from VWR's 40 largest customers and we receive a minimal fee
for all other orders for VWR core products forwarded to VWR. We are responsible
for fulfillment and customer service for all Chemdex core product and orders
for third party products received from VWR customers through the Chemdex
Marketplace. Under the terms of the agreement, VWR provides support for the
purchase of third party products in return for a fee which approximates VWR's
costs incurred.

   CMGI and/or its affiliates beneficially own 2,728,357 shares of Chemdex
common stock, representing approximately 8.3% of the outstanding Chemdex common
stock, and 3,996,800 shares of Promedix preferred stock, representing
approximately 42.3% of the outstanding Promedix capital stock. Following
consummation of the merger, CMGI and its affiliates will beneficially own
approximately 18.9% of the outstanding Chemdex common stock. Jonathan D.
Callaghan is a general partner of CMGX@ventures, a CMGI affiliate, and is a
member of both the Chemdex board of directors and the Promedix board of
directors.

Note 13. Recent Accounting Pronouncements

   In June 1998, the FASB issued FAS 133, Accounting for Derivative Instruments
and Hedging Activities, which we will be required to adopt for the year ending
December 31, 2001. FAS 133 establishes methods of accounting for derivative
financial instruments and hedging activities related to those instruments as
well as other hedging activities. Because we currently hold no derivative
financial instruments and do not currently engage in hedging activities,
adoption of FAS 133 is not expected to have a material impact on our financial
condition or results of operations.

   In March 1998, the American Institute of Certified Public Accounts (AICPA)
issued Statement of Position (SOP) No. 98-1, Accounting for the Costs of
Computer Software Developed or Obtained for Internal Use. SOP No. 98-1 requires
entities to capitalize some of the costs related to internal-use software once
the applicable criteria have been met. We expect that the adoption of SOP No.
98-1 will not have a material impact on our financial position or results of
operations. The Company will adopt this standard in fiscal 2000.

Note 14. Proposed acquisition of Promedix

   On September 22, 1999 the Company entered into a definitive agreement to
acquire Promedix, a provider of e-commerce solutions for healthcare purchasing
professionals. Promedix is a privately held Company based in Salt Lake City,
Utah. Promedix links buyers and suppliers of specialty medical products,
providing healthcare professionals with a one-stop shop for product research,
purchase and order fulfillment through relationships with distributors and
manufacturers. Under the terms of the acquisition agreement, the Company will
issue approximately 12.1 million shares of its common stock for all of the
outstanding preferred and common stock of Promedix based on an exchange ratio
of the Company's common stock for each share of Promedix preferred and common
stock determined on the closing date of the transaction. The transaction will
be accounted for as a purchase. The Company's preliminary unaudited estimate of
the total purchase consideration is approximately $315.8 million, based on the
fair value at the time of the announcement of the

                                      F-10
<PAGE>

                              CHEMDEX CORPORATION

        NOTES TO CONDENSED FINANCIAL STATEMENTS (Unaudited)--(Continued)

acquisition, of common stock to be issued. Under a provision in the agreement,
Chemdex or Promedix could be required to pay other party a $10 million
cancellation fee if the purchase is cancelled. As part of the agreement,
Chemdex has executed a $10 million promissory note to Promedix, with an
interest rate of 9%. At September 30, 1999, no borrowings were outstanding
related to the note. The acquisition has been approved by the boards of
directors of Chemdex and Promedix, but is subject to several conditions,
including approval by both companies' stockholders.

                                      F-11
<PAGE>

               REPORT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

The Board of Directors and Stockholders
Chemdex Corporation

   We have audited the accompanying balance sheets of Chemdex Corporation as of
December 31, 1997 and 1998, and the related statements of operations,
stockholders' equity, and cash flows for the period from September 4, 1997
(inception) through December 31, 1997 and for the year ended December 31, 1998.
These financial statements are the responsibility of the Company's management.
Our responsibility is to express an opinion on these financial statements based
on our audits.

   We conducted our audits in accordance with generally accepted auditing
standards. Those standards require that we plan and perform the audit to obtain
reasonable assurance about whether the financial statements are free of
material misstatement. An audit includes examining, on a test basis, evidence
supporting the amounts and disclosures in the financial statements. An audit
also includes assessing the accounting principles used and significant
estimates made by management, as well as evaluating the overall financial
statement presentation. We believe that our audits provide a reasonable basis
for our opinion.

   In our opinion, the financial statements referred to above present fairly,
in all material respects, the financial position of Chemdex Corporation at
December 31, 1997 and 1998, and the results of its operations and its cash
flows for the period from September 4, 1997 (inception) through December 31,
1997 and for the year ended December 31, 1998, in conformity with generally
accepted accounting principles.

                                          Ernst & Young LLP

San Jose, California
May 7, 1999,
except for Note 9,
as to which the date is
July 23, 1999


                                      F-12
<PAGE>

                              CHEMDEX CORPORATION

                                 BALANCE SHEETS
<TABLE>
<CAPTION>
                                                                    Pro Forma
                                                                  Stockholders'
                                December 31,                      Equity as of
                           -----------------------   March 31,      March 31,
                              1997        1998          1999          1999
                           ----------  -----------  ------------  -------------
                                                    (Unaudited)    (Unaudited)
<S>                        <C>         <C>          <C>           <C>
Assets
Current assets:
 Cash and cash
  equivalents............. $1,346,478  $ 5,990,188  $ 27,783,684
 Accounts receivable, net
  of allowances for bad
  debt of $0, $2,000 and
  $4,000 at December 31,
  1997 and 1998 and March
  31, 1999................        --        32,259       126,354
 Other current assets.....     43,137      286,991       416,973
                           ----------  -----------  ------------
   Total current assets...  1,389,615    6,309,438    28,327,011
Property and equipment:
 Furniture and fixtures...      9,719      298,591       551,843
 Computer hardware and
  software................    245,826    1,498,220     3,805,930
 Leasehold improvements...     12,911       46,470       139,105
                           ----------  -----------  ------------
                              268,456    1,843,281     4,496,878
 Less accumulated
  depreciation and
  amortization............      7,337      285,036       495,090
                           ----------  -----------  ------------
                              261,119    1,558,245     4,001,788
Other assets..............     77,278      300,472       307,087
                           ----------  -----------  ------------
Total assets.............. $1,728,012  $ 8,168,155  $ 32,635,886
                           ==========  ===========  ============
Liabilities and
 stockholders' equity
Current liabilities:
 Accounts payable......... $  181,671  $   543,141  $  1,042,656
 Accrued compensation.....     31,621      511,578       692,545
 Accrued expenses.........     54,120      759,654     1,902,725
 Current obligations under
  capital leases..........      6,483        5,425           --
 Current portion of note
  payable.................        --           --        328,833
                           ----------  -----------  ------------
   Total current
    liabilities...........    273,895    1,819,798     3,966,759
 Obligations under capital
  leases..................      5,982          --            --
 Note payable, less
  current portion.........        --           --        803,028
                           ----------  -----------  ------------
   Total liabilities......    279,877    1,819,798     4,769,787
Commitments and
 contingencies
Stockholders' equity:
 Convertible preferred
  stock, $.0002 par value:
   Authorized shares --
    34,074,632 in 1999 and
    none pro forma
    Issued and outstanding
    shares -- 2,695,550 in
    1997, 11,445,642 in
    1998, 16,345,701 in
    1999 and none pro
    forma (liquidation
    preference of
    $42,939,012 at March
    31,1999)..............        539        2,289         3,269  $        --
 Common stock, $.0002 par
  value:
   Authorized shares --
    9,500,000 in 1997,
    17,500,000 in 1998 and
    50,000,000 in 1999....
   Issued and outstanding
    shares--2,570,000 in
    1997, 3,921,835 in
    1998, 4,830,420 in
    1999, and 21,176,121
    pro forma.............        514          784           966         4,235
 Additional paid-in
  capital.................  1,850,475   18,378,907    50,139,579    50,139,579
 Deferred compensation....        --    (2,992,099)   (5,491,688)   (5,491,688)
 Notes receivable from
  stockholders............        --      (149,717)   (1,085,374)   (1,085,374)
 Accumulated deficit......   (403,393)  (8,891,807)  (15,700,653)  (15,700,653)
                           ----------  -----------  ------------  ------------
    Total stockholders'
     equity...............  1,448,135    6,348,357    27,866,099  $ 27,866,099
                           ----------  -----------  ------------  ============
Total liabilities and
 stockholders' equity..... $1,728,012  $ 8,168,155  $ 32,635,886
                           ==========  ===========  ============
</TABLE>

                            See accompanying notes.

                                      F-13
<PAGE>

                              CHEMDEX CORPORATION

                            STATEMENTS OF OPERATIONS

<TABLE>
<CAPTION>
                             Period from
                              Inception
                         (September 4, 1997) Year Ended    Three Months Ended
                               through        December          March 31,
                            December 31,         31,      ----------------------
                                1997            1998        1998        1999
                         ------------------- -----------  ---------  -----------
                                                               (Unaudited)
<S>                      <C>                 <C>          <C>        <C>
Net revenues............      $     --       $    29,355  $     --   $   165,552
Cost of revenues........            --            22,105        --       155,960
                              ---------      -----------  ---------  -----------
Gross profit............            --             7,250        --         9,592
Operating expenses:
  Research and
   development..........        196,388        3,439,135    363,745    2,293,311
  Sales and marketing...         86,346        3,247,136    219,086    3,188,058
  General and
   administrative.......        120,659        1,744,898    189,896    1,014,748
  Amortization of
   deferred
   compensation.........            --           372,285     22,434      352,291
                              ---------      -----------  ---------  -----------
  Total operating
   expenses.............        403,393        8,803,454    795,161    6,848,408
                              ---------      -----------  ---------  -----------
Operating loss..........       (403,393)      (8,796,204)  (795,161)  (6,838,816)
Interest expense........            --            (2,620)      (754)     (24,928)
Interest income and
 other, net.............            --           310,410      3,319       54,898
                              ---------      -----------  ---------  -----------
Net loss................      $(403,393)     $(8,488,414) $(792,596) $(6,808,846)
                              =========      ===========  =========  ===========
Basic and diluted net
 loss per share.........      $    (.24)     $     (4.79) $    (.47) $     (3.38)
                              =========      ===========  =========  ===========
Weighted average shares
 of common stock
 outstanding used in
 computing basic and
 diluted net loss per
 share..................      1,704,412        1,771,508  1,704,412    2,016,176
                              =========      ===========  =========  ===========
Pro forma basic and
 diluted net loss per
 share..................                     $      (.85)            $      (.48)
                                             ===========             ===========
Weighted average shares
 used in computing pro
 forma basic and diluted
 net loss per share.....                       9,952,554              14,278,540
                                             ===========             ===========
</TABLE>


                            See accompanying notes.

                                      F-14
<PAGE>

                              CHEMDEX CORPORATION

                       STATEMENTS OF STOCKHOLDERS' EQUITY

<TABLE>
<CAPTION>
                       Convertible
                     Preferred Stock    Common Stock    Additional                                                Total
                    ----------------- -----------------   Paid-in      Deferred       Notes     Accumulated   Stockholders'
                      Shares   Amount  Shares    Amount   Capital    Compensation  Receivable     Deficit        Equity
                    ---------- ------ ---------  ------ -----------  ------------  -----------  ------------  -------------
<S>                 <C>        <C>    <C>        <C>    <C>          <C>           <C>          <C>           <C>
Issuance of Series
 A preferred stock
 at $0.6994 per
 share, net of
 issuance costs...   2,695,550 $  539       --    $--   $ 1,850,475  $       --    $       --   $        --    $ 1,851,014
Issuance of common
 stock to founders
 on
 incorporation....         --     --  2,570,000    514          --           --            --            --            514
Net loss..........                                                                                  (403,393)     (403,393)
                    ---------- ------ ---------   ----  -----------  -----------   -----------  ------------   -----------
Balance at
 December 31,
 1997.............   2,695,550    539 2,570,000    514    1,850,475          --            --       (403,393)    1,448,135
Issuance of Series
 A preferred stock
 at $0.6994 per
 share, net of
 issuance costs...     100,100     20       --     --        44,847          --            --            --         44,867
Issuance of Series
 B preferred stock
 at $1.50 per
 share, net of
 issuance costs...   8,649,992  1,730       --     --    12,928,827          --            --            --     12,930,557
Exercise of stock
 options..........         --     --  1,419,335    284      197,486          --       (156,843)          --         40,927
Repurchase of
 unvested shares..         --     --    (67,500)   (14)      (7,112)         --          7,126           --            --
Deferred
 compensation
 relating to stock
 options..........         --     --        --     --     3,364,384   (3,364,384)          --            --            --
Amortization of
 deferred
 compensation
 relating to stock
 options..........         --     --        --     --           --       372,285           --            --        372,285
Net loss..........         --     --        --     --           --           --            --     (8,488,414)   (8,488,414)
                    ---------- ------ ---------   ----  -----------  -----------   -----------  ------------   -----------
Balance at
 December 31,
 1998.............  11,445,642  2,289 3,921,835    784   18,378,907   (2,992,099)     (149,717)   (8,891,807)    6,348,357
Issuance of Series
 C preferred stock
 at $5.716 per
 share, net of
 issuance costs
 (unaudited)......   4,900,059    980       --     --    27,934,075          --            --            --     27,935,055
Exercise of stock
 options
 (unaudited)......         --     --  1,071,000    214      958,303          --       (956,964)          --          1,553
Repurchase of
 unvested shares
 (unaudited)......         --     --   (162,415)   (32)     (17,959)         --         17,991           --            --
Payments of
 stockholders'
 notes receivable
 (unaudited)......         --     --        --     --           --           --          3,316           --          3,316
Issuance of
 warrants
 (unaudited)......         --     --        --     --        34,373          --            --            --         34,373
Deferred
 compensation
 relating to stock
 options
 (unaudited)......         --     --        --     --     2,851,880   (2,851,880)          --            --            --
Amortization of
 deferred
 compensation
 relating to stock
 options
 (unaudited)......         --     --        --     --           --       352,291           --            --        352,291
Net loss
 (unaudited)......         --     --        --     --           --           --            --     (6,808,846)   (6,808,846)
                    ---------- ------ ---------   ----  -----------  -----------   -----------  ------------   -----------
Balance at March
 31, 1999
 (unaudited)......  16,345,701 $3,269 4,830,420   $966  $50,139,579  $(5,491,688)  $(1,085,374) $(15,700,653)  $27,866,099
                    ========== ====== =========   ====  ===========  ===========   ===========  ============   ===========
</TABLE>

                            See accompanying notes.

                                      F-15
<PAGE>

                              CHEMDEX CORPORATION

                            STATEMENTS OF CASH FLOWS

<TABLE>
<CAPTION>
                              Period from
                               Inception
                             (September 4,                 Three Months Ended
                             1997) through  Year Ended         March 31,
                             December 31,  December 31,  -----------------------
                                 1997          1998         1998        1999
                             ------------- ------------  ----------  -----------
                                                              (Unaudited)
<S>                          <C>           <C>           <C>         <C>
Operating activities
Net loss...................   $ (403,393)  $(8,488,414)  $ (792,596) $(6,808,846)
Adjustments to reconcile
 net loss to net cash used
 in operating activities:
 Depreciation and
  amortization.............        7,337       301,201       31,093      210,054
 Amortization of deferred
  compensation and sales
  and marketing and
  interest expense related
  to warrants..............          --        372,285       22,434      386,664
 Loss on disposal of
  property and equipment...          --          7,925          --           --
 Changes in operating
  assets and liabilities:
   Accounts receivable.....          --        (32,259)     (15,454)     (94,095)
   Other current assets....      (43,137)     (243,854)      (5,101)    (129,982)
   Other assets............      (67,064)     (239,812)     (14,521)      (6,615)
   Accounts payable........      181,671       361,470      (11,534)     499,515
   Accrued compensation....       31,621       479,957       28,891      180,967
   Accrued expenses........       54,120       705,534       94,757    1,143,071
                              ----------   -----------   ----------  -----------
Net cash used in operating
 activities................     (238,845)   (6,775,967)    (662,031)  (4,619,267)
                              ----------   -----------   ----------  -----------
Investing activities
Sales of short-term
 investments...............          --      6,593,495          --           --
Purchases of short-term
 investments...............          --     (6,593,495)         --           --
Purchases of property and
 equipment.................     (255,545)   (1,614,129)    (181,130)  (1,521,736)
Proceeds from sales of
 property and equipment....          --         24,495          --           --
Purchase of other assets...      (10,214)          --           --           --
                              ----------   -----------   ----------  -----------
Net cash used in investing
 activities................     (265,759)   (1,589,634)    (181,130)  (1,521,736)
                              ----------   -----------   ----------  -----------
Financing activities
Principal payments on
 capital lease
 obligations...............         (446)       (7,040)      (1,854)      (5,425)
Net proceeds from issuance
 of preferred stock........    1,851,014    12,975,424          --    27,935,055
Issuance of common stock...          514        40,927        9,867        1,553
Payments of stockholders'
 notes receivable..........          --            --           --         3,316
                              ----------   -----------   ----------  -----------
Net cash provided by
 financing activities......    1,851,082    13,009,311        8,013   27,934,499
                              ----------   -----------   ----------  -----------
Net increase (decrease) in
 cash and cash
 equivalents...............    1,346,478     4,643,710     (835,148)  21,793,496
Cash and cash equivalents
 at beginning of period....          --      1,346,478    1,346,478    5,990,188
                              ----------   -----------   ----------  -----------
Cash and cash equivalents
 at end of period..........   $1,346,478   $ 5,990,188   $  511,330  $27,783,684
                              ==========   ===========   ==========  ===========
Supplemental disclosures of
 noncash activities:
Issuance of shares in
 exchange for stockholders'
 notes receivable..........   $      --    $   156,843   $      --   $   956,964
                              ==========   ===========   ==========  ===========
Repurchase of common stock
 issued in exchange for
 stockholders' notes
 receivable................   $      --    $     7,126   $      --   $    17,991
                              ==========   ===========   ==========  ===========
Equipment purchased under
 capital lease and note
 payable...................   $   12,911   $       --    $      --   $ 1,131,861
                              ==========   ===========   ==========  ===========
Supplemental disclosure of
 cash flow information:
Cash paid for interest.....   $      207   $     2,620   $      754  $       165
                              ==========   ===========   ==========  ===========
Cash paid for taxes........   $      --    $     1,991   $    1,973  $     1,700
                              ==========   ===========   ==========  ===========
</TABLE>

                            See accompanying notes.

                                      F-16
<PAGE>

                              CHEMDEX CORPORATION

                         NOTES TO FINANCIAL STATEMENTS

(Information as of March 31, 1999 and for the three months ended March 31, 1998
                             and 1999 is unaudited)

1. Description of Business

   Chemdex is a provider of e-commerce solutions to the life sciences research
products market. Chemdex enables life sciences enterprises, researchers and
suppliers to efficiently buy and sell research products through the Chemdex
Marketplace, a secure, Internet-based purchasing solution.

   Chemdex was incorporated in Delaware on September 4, 1997. During the period
from inception through November 1998, Chemdex was a development stage company
and did not have significant sales. During this period, operating activities
related primarily to the design and development of Chemdex's online marketplace
and corporate infrastructure and the establishment of relationships with
suppliers and customers. Chemdex has incurred operating losses to date and had
an accumulated deficit of approximately $15.7 million at March 31, 1999.
Chemdex's activities have been primarily financed through private placements of
equity securities. Chemdex is no longer in the development stage.

2. Summary of Significant Accounting Policies

 Use of Estimates

   The preparation of financial statements in conformity with generally
accepted accounting principles requires management to make estimates and
assumptions that affect the amounts reported in the financial statements and
accompanying notes. Actual results could differ from those estimates.

 Interim Financial Information

   The financial information as of March 31, 1999 and for the three months
ended March 31, 1998 and 1999 is unaudited and includes all adjustments,
consisting only of normal recurring adjustments, that Chemdex's management
considers necessary for a fair presentation of Chemdex's operating results and
cash flows for the period. Results for the three month period ended March 31,
1999 are not necessarily indicative of results to be expected for the full
fiscal year of 1999 or for any future period.

 Revenue Recognition

   Net revenues consist primarily of product sales to customers and charges to
customers for outbound freight. Under most supplier agreements, Chemdex acts as
a principal when purchasing products from suppliers and reselling them to
customers. Products are shipped directly to customers by suppliers based on
customer delivery date specifications. Under principal-based agreements,
Chemdex is responsible for selling products, collecting payment from customers,
ensuring that the shipment reaches customers and processing returns. In
addition, Chemdex takes title to products upon shipment and bears the risk of
loss for collection, delivery and product returns from customers. Chemdex
provides an allowance for sales returns, which has been insignificant to date,
at the time of sale. Chemdex recognizes revenues from product sales when
products are shipped to customers.

   To date, an insignificant amount of revenue is from agreements with
suppliers for which Chemdex is acting as an agent. Under agency-based supplier
agreements, Chemdex recognizes a percentage share of revenues generated by
suppliers when products are shipped to customers.

   For the year ended December 31, 1998 and the three months ended March 31,
1999, one customer accounted for 79% and 82% of net revenues, respectively. For
the year ended December 31, 1998, another

                                      F-17
<PAGE>

                              CHEMDEX CORPORATION

                   NOTES TO FINANCIAL STATEMENTS--(Continued)

        (Information as of March 31, 1999 and for the three months ended
                     March 31, 1998 and 1999 is unaudited)

customer accounted for 14% of net revenues. There were no sales to customers
outside the United States since inception through March 31, 1999.

 Cash and Cash Equivalents

   Cash equivalents consist of financial instruments which are readily
convertible to cash and have original maturities of three months or less at the
time of acquisition. Chemdex's cash and cash equivalents as of December 31,
1997 and 1998 and March 31, 1999 consisted primarily of commercial paper and
money market funds held by large financial institutions in the United States,
and their carrying value approximated fair value.

 Property and Leasehold Improvements

   Chemdex records property and equipment at cost and calculates depreciation
using the straight-line method over estimated useful lives of three to five
years. Property under capital leases is depreciated over the lesser of the
useful lives of the assets or lease term.

 Stock-Based Compensation

   Chemdex has elected to follow Accounting Principles Board Opinion No. 25,
Accounting for Stock Issued to Employees, ("APB Opinion No. 25"), and related
interpretations in accounting for its employee stock options because, as
discussed in Note 6, the alternative fair value accounting provided for under
Statement of Financial Accounting Standards No. 123, Accounting for Stock-Based
Compensation, ("FAS 123"), requires use of option valuation models that were
not developed for use in valuing employee stock options. Under APB Opinion
No. 25, when the exercise price of Chemdex's employee stock options equals the
market price of the underlying stock on the date of grant, no compensation
expense is recognized. See pro forma disclosures of applying FAS 123 included
in Note 6.

 Advertising Costs

   Advertising costs are charged to expense when incurred. No advertising
expense was incurred for the period from September 4, 1997 (inception) through
December 31, 1997. Advertising expense was $786,520 and $1.2 million for the
year ended December 31, 1998 and the three months ended March 31, 1999,
respectively.

 Comprehensive Income

   In June 1997, the Financial Accounting Standards Board issued FAS 130,
Reporting Comprehensive Income. FAS 130 establishes standards for the reporting
and display of comprehensive income and its components in a full set of general
purpose financial statements and is effective for fiscal years beginning after
December 15, 1997. Chemdex adopted FAS 130 in the year ended December 31, 1998.
Chemdex had no comprehensive income items to report for the year ended December
31, 1998 and the three months ended March 31, 1999.

 Segment Information

   In June 1997, the Financial Accounting Standards Board issued FAS 131,
Disclosures about Segments of an Enterprise and Related Information ("FAS
131"). FAS 131 changes the way companies report selected segment information in
annual financial statements and requires companies to report selected segment
information in interim financial reports to stockholders. Chemdex adopted FAS
131 in the year ended December 31, 1998.

                                      F-18
<PAGE>

                              CHEMDEX CORPORATION

                   NOTES TO FINANCIAL STATEMENTS--(Continued)

        (Information as of March 31, 1999 and for the three months ended
                     March 31, 1998 and 1999 is unaudited)


   Chemdex operates solely in one operating segment, the development and
marketing of an online marketplace for the purchasing and distribution of
products and, therefore there is no impact to Chemdex's financial statements of
adopting FAS 131.

 Net Loss Per Share

   Basic and diluted net loss per common share is presented in conformity with
FAS No. 128, Earnings Per Share ("FAS 128"), for all periods presented.
Pursuant to the Securities and Exchange Commission Staff Accounting Bulletin
No. 98, common stock and convertible preferred stock issued or granted for
nominal consideration prior to the anticipated effective date of Chemdex's
initial public offering must be included in the calculation of basic and
diluted net loss per common share as if they had been outstanding for all
periods presented. To date, Chemdex has not had any issuances or grants for
nominal consideration.

   In accordance with FAS 128, basic and diluted net loss per share has been
computed using the weighted-average number of shares of common stock
outstanding during the period, less shares subject to repurchase. Pro forma
basic and diluted net loss per share, as presented in the statements of
operations, has been computed as described above and also gives effect, under
Securities and Exchange Commission guidance, to the conversion of the
convertible preferred stock (using the if-converted method) from the original
date of issuance.

   The following table presents the calculation of basic and diluted and pro
forma basic and diluted net loss per share:

<TABLE>
<CAPTION>
                            Period from
                             Inception
                           (September 4,                 Three Months Ended
                           1997) through  Year Ended         March 31,
                           December 31,  December 31,  -----------------------
                               1997          1998         1998        1999
                           ------------- ------------  ----------  -----------
<S>                        <C>           <C>           <C>         <C>
Net loss..................   $(403,393)  $(8,488,414)  $ (792,596) $(6,808,846)
                             =========   ===========   ==========  ===========
Basic and diluted:
 Weighted-average shares
  of common stock
  outstanding.............   2,570,000     3,242,795    2,570,000    4,523,065
 Less weighted-average
  shares subject to
  repurchase..............    (865,588)   (1,471,286)    (865,588)  (2,506,889)
                             ---------   -----------   ----------  -----------
 Weighted-average shares
  used in computing basic
  and diluted net loss per
  common share............   1,704,412     1,771,508    1,704,412    2,016,176
                             =========   ===========   ==========  ===========
 Basic and diluted net
  loss per common share...   $    (.24)  $     (4.79)  $     (.47) $     (3.38)
                             =========   ===========   ==========  ===========
Pro forma:
 Shares used above........                 1,771,508                 2,016,176
  Pro forma adjustment to
   reflect weighted-
   average effect of the
   assumed conversion of
   convertible preferred
   stock..................                 8,181,046                12,262,364
                                         -----------               -----------
  Shares used in computing
   pro forma basic and
   diluted net loss per
   share..................                 9,952,554                14,278,540
                                         ===========               ===========
  Pro forma basic and
   diluted net loss per
   share..................               $      (.85)              $      (.48)
                                         ===========               ===========
</TABLE>

                                      F-19
<PAGE>

                              CHEMDEX CORPORATION

                   NOTES TO FINANCIAL STATEMENTS--(Continued)

        (Information as of March 31, 1999 and for the three months ended
                     March 31, 1998 and 1999 is unaudited)


   Chemdex has excluded all outstanding stock options and shares subject to
repurchase by Chemdex from the calculation of diluted loss per share because
these securities are antidilutive for all periods presented. Weighted-average
options outstanding to purchase -0-, 508,750 and 439,852 shares of common stock
for the period from inception through December 31, 1997, the year ended
December 31, 1998 and the three months ended March 31, 1999, respectively, were
not included in the computation of diluted net loss per share because the
effect would be antidilutive. Such securities, had they been dilutive, would
have been included in the computation of diluted net loss per share using the
treasury stock method.

 Unaudited Pro Forma Stockholders' Equity

   If the offering contemplated by this prospectus is consummated, each share
of convertible preferred stock outstanding will automatically be converted into
one share of common stock. Unaudited pro forma stockholders' equity at March
31, 1999, as adjusted for the assumed conversion of convertible preferred stock
based on the shares of convertible preferred stock outstanding at March 31,
1999, is disclosed on the balance sheet.

 Recent Accounting Pronouncements

   In June 1998, the FASB issued FAS 133, Accounting for Derivative Instruments
and Hedging Activities ("FAS 133"), which Chemdex will be required to adopt for
the year ending December 31, 2000. This statement establishes a new model for
accounting for derivatives and hedging activities. FAS 133 establishes methods
of accounting for derivative financial instruments and hedging activities
related to those instruments as well as other hedging activities. Because
Chemdex currently holds no derivative financial instruments and does not
currently engage in hedging activities, adoption of FAS 133 is expected to have
no material impact on Chemdex's financial condition or results of operations.

   In March 1998, the American Institute of Certified Public Accountants
(AICPA) issued SOP 98-1, Accounting for the Costs of Computer Software
Developed or Obtained for Internal Use, ("SOP 98-1"). SOP 98-1 requires that
entities capitalize certain costs related to internal use software once certain
criteria have been met. Chemdex is required to implement SOP 98-1 for the year
ending December 31, 1999. Adoption of SOP 98-1 is not expected to have a
material impact on Chemdex's financial condition or results of operations.

   In April 1998, the AICPA issued SOP No. 98-5, Reporting on the Costs of
Start-Up Activities, ("SOP 98-5"). SOP No. 98-5 requires that all start-up
costs related to new operations must be expensed as incurred. In addition, all
start-up cost that were capitalized in the past must be written off when SOP
No. 98-5 is adopted. Chemdex implemented SOP No. 98-5 on January 1, 1999. The
adoption of SOP No. 98-5 did not have a material impact on its financial
position or results of operations.

3. Concentrations of Credit Risk and Other Risks

   Financial instruments that potentially subject Chemdex to credit risk
consist primarily of uninsured cash and cash equivalents. Cash and cash
equivalents are deposited with a federally insured commercial bank in the
United States.

   Chemdex sells primarily to pharmaceutical and biotechnology companies and
academic and research institutions. Chemdex performs ongoing credit evaluations
of its customers but does not require collateral. Chemdex analyzes the need for
reserves for potential credit losses and records reserves when necessary. These
losses have been within management's expectations. To date, Chemdex has not had
significant write-offs of bad debt.

                                      F-20
<PAGE>

                              CHEMDEX CORPORATION

                   NOTES TO FINANCIAL STATEMENTS--(Continued)

        (Information as of March 31, 1999 and for the three months ended
                     March 31, 1998 and 1999 is unaudited)


4. Commitments

   Chemdex leases its office facilities under noncancelable operating leases
expiring through 2003. Minimum annual operating lease commitments at December
31, 1998 were as follows:

<TABLE>
      <S>                                                            <C>
      1999.......................................................... $1,080,184
      2000..........................................................  1,094,662
      2001..........................................................  1,127,501
      2002..........................................................  1,161,331
      2003..........................................................  1,196,165
                                                                     ----------
      Total minimum payments........................................ $5,659,843
                                                                     ==========
</TABLE>

   Rental expense for the period from Inception through December 31, 1997 and
the year ended December 31, 1998 was $13,939 and $342,977, respectively.

5. Financing Arrangements

   In February 1998, Chemdex entered into a line of credit with a bank, which
provides for borrowings of up to $400,000 with interest at the bank's prime
rate plus 1.0%. The aggregate credit line has a compensating balance
requirement of $210,000. Borrowings under the line are secured by substantially
all of the Chemdex's assets. At December 31, 1998, Chemdex had no outstanding
borrowings under this line of credit. The line of credit expired on February
17, 1999.

   In 1997, Chemdex entered into a noncancelable capital lease agreement for
equipment. Aggregate future minimum capital lease payments under this lease
were $5,425 at December 31, 1998. The lease expires in October 1999.

   In January 1999, Chemdex entered into a $3.0 million equipment lease line
agreement with a financial institution for a term of 48 months, with interest
imputed at 13.02% per year. At December 31, 1998 and March 31, 1999, Chemdex
had no outstanding borrowings under the equipment lease line.

   In February 1999, Chemdex entered into a financing arrangement in the amount
of $1,131,861 for the purchase of certain computer software and related
support. This arrangement provides for 12 equal quarterly payments of the
financed amount commencing May 1, 1999, with interest imputed at 13.24% per
year.

   As of March 31, 1999, aggregate future minimum payments under this financing
agreement were as follows:

<TABLE>
      <S>                                                            <C>
      1999.......................................................... $  270,977
      2000..........................................................    366,973
      2001..........................................................    418,623
      2002..........................................................     75,288
                                                                     ----------
      Total payments................................................  1,131,861
      Less current portion..........................................   (328,833)
                                                                     ----------
      Long-term portion............................................. $  803,028
                                                                     ==========
</TABLE>

                                      F-21
<PAGE>

                              CHEMDEX CORPORATION

                   NOTES TO FINANCIAL STATEMENTS--(Continued)

        (Information as of March 31, 1999 and for the three months ended
                     March 31, 1998 and 1999 is unaudited)


6. Stockholders' Equity

 Convertible Preferred Stock

   Convertible preferred stock at December 31, 1997 and 1998 and March 31, 1999
is as follows:

<TABLE>
<CAPTION>
                                                 Shares Issued and Outstanding
                                                -------------------------------
                                       Shares
                                     Authorized     December 31,     March 31,
                         Liquidation March 31,  -------------------- ----------
                         Preference     1999      1997       1998       1999
                         ----------- ---------- --------- ---------- ----------
<S>                      <C>         <C>        <C>       <C>        <C>
Series A................   $.6994     2,795,650 2,695,550  2,795,650  2,795,650
Series A-1..............   $.6994     2,795,650       --         --         --
Series B................   $ 1.50     8,791,666       --   8,649,992  8,649,992
Series B-1..............   $ 1.50     8,791,666       --         --         --
Series C................   $5.716     5,300,000       --         --   4,900,059
Series C-1..............   $5.716     5,300,000       --         --         --
Undesignated............                300,000       --         --         --
                                     ---------- --------- ---------- ----------
Total convertible
 preferred stock........             34,074,632 2,695,550 11,445,642 16,345,701
                                     ========== ========= ========== ==========
</TABLE>

   To date, shares have been designated as Series A and A-1, Series B and B-1
and Series C and C-1 (collectively, "the Series A, B and C preferred stock").

   Chemdex is authorized to issue additional preferred stock with such
designations, rights, and preferences as may be determined from time to time by
the Board of Directors provided, however, that any such preferred stock must be
subordinate to, or in parity with, the Series A, B and C preferred stock.

   Series A, B and C preferred stockholders have voting rights equal to the
common shares issuable upon conversion of the Series A, B and C preferred
stock.

   Each share of Series A, B and C preferred stock is convertible, at the
option of the holder, into one share of common stock, subject to certain
adjustments for dilutive issuances. Outstanding shares of Series A, B and C
preferred stock automatically convert into common stock upon the closing of an
underwritten public offering of Chemdex's common stock with gross proceeds to
Chemdex of at least $20,000,000 and a per share price of at least $7.50, or at
the election of the holders of more than 50%, at least 66 2/3% and at least 60%
of outstanding Series A, B and C preferred stock, respectively.

   Holders of Series A, B and C preferred stock are entitled to noncumulative
dividends of $.063 and $.135 and $.5144 per annum per outstanding share.
Dividends will be paid only when declared by the Board of Directors out of
legally available funds. No dividends have been declared or accrued as of March
31, 1999.

   Series A, B and C preferred stockholders are entitled to receive, upon a
liquidating event, an amount per share equal to the issuance price, plus all
declared but unpaid dividends. The remaining assets and funds, if any, shall be
distributed among the holders of Series A, B and C preferred stock and common
stock pro rata based on the number of shares of common stock held by each
(assuming conversion of all such Series A, B and C preferred stock). If any
assets remain after the holders of Series A, B and C preferred stock have
received an aggregate of $1.748, $3.75 and $14.29 per share, the remaining
assets will be distributed to the holders of the common stock pro rata based on
the number of shares of common stock held by each.

                                      F-22
<PAGE>

                              CHEMDEX CORPORATION

                   NOTES TO FINANCIAL STATEMENTS--(Continued)

        (Information as of March 31, 1999 and for the three months ended
                     March 31, 1998 and 1999 is unaudited)


 Warrants

   In January 1999, in connection with an equipment lease line, Chemdex issued
a fully vested warrant that entitles the holder to purchase 105,000 shares of
the Chemdex's Series B preferred stock at an exercise price of $1.50 per share.
This warrant is exercisable, through the later of the initial public offering
of Chemdex's common stock or January 2006. The fair value of this warrant,
approximately $195,300, will be expensed as a cost of financing over the four
year period of the lease line. The fair value of this warrant was calculated
using the Black-Scholes option pricing model.

   In March 1999, Chemdex issued a fully vested, non-forfeitable warrant in
exchange for consulting services. The warrant entitles the holder to purchase
49,999 shares of Chemdex's common stock at an exercise price of $5.20 per
share. This warrant is exercisable through the earlier of two years from the
date of the initial public offering of Chemdex's common stock or March 2006.
The fair value of this warrant, approximately $133,000, will be expensed over
the six month period of the consulting agreement. The fair value of this
warrant was calculated using the Black-Scholes option pricing model.

 Common Stock

   Each share of common stock is entitled to one vote. The holders of common
stock are also entitled to receive dividends from legally available funds when
and if declared by the Board of Directors, subject to the prior rights of
holders of Series A, B and C preferred stock.

   Certain shares of common stock issued to founders of Chemdex, totaling
865,588 shares, are subject to repurchase by Chemdex. The stock vests over a
period of four years. As of December 31, 1998 and March 31, 1999, 730,136 and
677,521 shares, respectively, were subject to repurchase.

   At March 31, 1999, common stock was reserved for future issuance as follows:

<TABLE>
      <S>                                                             <C>
      Conversion of Series A preferred stock.........................  2,795,650
      Conversion of Series B preferred stock.........................  8,649,992
      Conversion of Series C preferred stock.........................  4,900,059
      Warrants.......................................................    154,999
      Stock Option Plan..............................................  1,114,580
                                                                      ----------
                                                                      17,615,280
                                                                      ==========
</TABLE>

 Stock Option Plans

   In January 1998, the Board of Directors terminated the 1997 Option Plan,
under which no options had been granted, and adopted the 1998 Stock Plan (the
"1998 Plan") for issuance of common stock to eligible participants. The Plan
provides for the granting of incentive stock options and non-qualified stock
options. Incentive stock options and non-qualified stock options may be granted
under the 1998 Plan at prices not less than 100% and 85% of the fair value at
the date of grant, or at prices not less than 110% for individuals owning more
than 10% of the combined voting power of all classes of stock at the date of
grant. Options generally expire after ten years. Certain options under the plan
are immediately exercisable; however, these shares issued are subject to
Chemdex's right to repurchase at the original issuance price, which right
lapses in a series of installments measured from the vesting commencement date
of the option. As of December 31, 1998 and March 31, 1999, 1,104,713 and
1,891,493 shares, respectively, were subject to repurchase. Options generally
vest, and the repurchase rights lapse ratably, over a period of four years from
the date of grant.

                                      F-23
<PAGE>

                              CHEMDEX CORPORATION

                   NOTES TO FINANCIAL STATEMENTS--(Continued)

        (Information as of March 31, 1999 and for the three months ended
                     March 31, 1998 and 1999 is unaudited)


   Pro forma information regarding net loss and net loss per share is required
by FAS 123, and has been determined as if Chemdex had accounted for its
employee stock options under the fair value method provided for in FAS 123. The
fair value of options was estimated at the date of grant using a minimum value
option pricing model with the following weighted-average assumptions for
options granted during the year ended December 31, 1998: risk-free interest
rate of 5.42%, an expected life of four years and no dividends.

   For purposes of pro forma disclosures, the estimated fair value of the
options is amortized to expense over the vesting period of the options using a
graded vesting method. The effects of applying FAS 123 for pro forma
disclosures are not likely to be representative of the effects on reported net
loss for future years.

   The option valuation models were developed for use in estimating the fair
value of traded options, which have no vesting restrictions and are fully
transferable. In addition, option valuation models require the input of highly
subjective assumptions, including the expected stock price volatility. Because
Chemdex's employee stock options have characteristics significantly different
from those of traded options and because changes in the subjective input
assumptions can materially affect the fair value estimate, in management's
opinion, the existing models do not necessarily provide a reliable single
measure of the fair value of its employee stock options.

<TABLE>
<CAPTION>
                                     Period from
                                      Inception                Three Months
                                    (September 4,                  Ended
                                    1997) through  Year Ended    March 31,
                                    December 31,  December 31, --------------
                                        1997          1998     1998    1999
                                    ------------- ------------ -----  -------
                                     (In Thousands, Except Per Share Data)
<S>                                 <C>           <C>          <C>    <C>
Net loss:
  As reported......................     $(403)      $(8,488)   $(793) $(6,809)
  Pro forma........................     $(403)      $(8,495)   $(793) $(6,818)
Pro forma basic and diluted net
 loss per share:
  As reported......................                 $  (.85)          $  (.48)
  Pro forma........................                 $  (.85)          $  (.48)
</TABLE>

   Activity under the 1998 Stock Plan was as follows:

<TABLE>
<CAPTION>
                                                Options Outstanding
                             Shares    ---------------------------------------
                           Available   Number of   Price per  Weighted-Average
                           for Grant     Shares      Share     Exercise Price
                           ----------  ----------  ---------- ----------------
<S>                        <C>         <C>         <C>        <C>
  Authorized..............  3,375,000         --          --         --
  Granted................. (1,978,835)  1,978,835  $.10-$1.00      $ .16
  Exercised...............        --   (1,419,335) $.10-$ .15      $ .12
  Canceled................     50,750     (50,750) $.10-$1.00      $ .12
  Repurchased.............     67,500         --   $.10-$ .15      $ .11
                           ----------  ----------
Balance at December 31,
 1998.....................  1,514,415     508,750  $.10-$1.00      $ .14
  Granted................. (1,010,102)  1,010,102       $1.50      $1.50
  Exercised...............        --   (1,071,000) $.15-$1.50      $ .90
  Canceled................      8,000      (8,000)      $1.50      $1.50
  Repurchased.............    162,415         --   $.10-$ .15      $ .10
                           ----------  ----------
Balance at March 31,
 1999.....................    674,728     439,852  $.10-$1.50      $1.02
                           ==========  ==========
</TABLE>

                                      F-24
<PAGE>

                              CHEMDEX CORPORATION

                   NOTES TO FINANCIAL STATEMENTS--(Continued)

        (Information as of March 31, 1999 and for the three months ended
                     March 31, 1998 and 1999 is unaudited)


   The following table summarizes information about stock options outstanding
and exercisable at December 31, 1998:

<TABLE>
<CAPTION>
                                    Options Outstanding and Exercisable
                              -----------------------------------------------------------------
                                                                                     Weighted-
                                                        Weighted-                     Average
         Range of             Number                     Average                     Remaining
         Exercise               of                      Exercise                    Contractual
          Prices              Shares                      Price                        Life
         --------             -------                   ---------                   -----------
                                                                                    (In Years)
        <S>                   <C>                       <C>                         <C>
        $.10--$1.00           508,750                     $.14                         9.14
</TABLE>

   Certain grants of options to employees to purchase common stock under
Chemdex's 1998 Stock Option Plan were exercised in exchange for full recourse
notes receivable. These notes receivable generally bear interest at a rate
equal to the minimum rate necessary to avoid the imputation of interest income
to the Company and compensation income to the maker under the Internal Revenue
Code and are collateralized by the underlying common stock. At December 31,
1998 and March 31, 1999, notes receivable in exchange for exercises of options
totaled $149,717 and $1,085,374, respectively. These shares are subject to
right of repurchase that generally lapse over four years.

   The weighted-average fair value of options granted during 1998 with an
exercise price equal to the fair value of common stock on the date of grant was
$.16. The weighted-average fair value of options granted during 1998 with an
exercise price below the deemed fair value of Chemdex's common stock on the
date of grant was $.16.

   In connection with the grant of share options to employees through March 31,
1999, Chemdex recorded deferred compensation of $6,216,264 for the aggregate
differences between the exercise prices of options at their dates of grant and
the deemed fair value for accounting purposes of the common shares subject to
these options. Such amount is included as a reduction of stockholders' equity
and is being amortized on a straight-line vesting method over the option
vesting periods, which are generally four years. The compensation expense of
$724,576 through March 31, 1999 relates to options awarded to employees in all
operating expense categories. This amount has not been separately allocated to
these categories.

7. Employee Savings and Retirement Plan

   Chemdex has a 401(k) plan that allows eligible employees to contribute up to
15% of their salary, subject to annual limits. Under the plan, eligible
employees may defer a portion of their pretax salaries but not more than
statutory limits. Chemdex may make discretionary contributions to the plan
based on profitability as determined by the Board of Directors. Chemdex did not
make any contributions to the plan during the year ended December 31, 1998, and
the three months ended March 31, 1999.

8. Income Taxes

   The difference between the amount of income tax benefit recorded and the
amount of income tax benefit calculated using the federal statutory rate of 34%
is due to net operating losses having a valuation allowance, due to past
operating results and uncertainties regarding Chemdex's future results of
operations. Accordingly, there is no provision for income taxes for the period
from September 4, 1997 (inception) through December 31, 1997 and for the year
ended December 31, 1998.

                                      F-25
<PAGE>

                              CHEMDEX CORPORATION

                   NOTES TO FINANCIAL STATEMENTS--(Continued)

        (Information as of March 31, 1999 and for the three months ended
                     March 31, 1998 and 1999 is unaudited)


   As of December 31, 1998, Chemdex had federal and state net operating loss
carryforwards of approximately $7,500,000 and $7,400,000, respectively. Chemdex
also had federal and state research credit carryforwards of approximately
$100,000 and $100,000, respectively. The net operating loss and credit
carryforwards will expire at various dates beginning in 2002 through 2018, if
not utilized. The net operating loss carryforwards differ from the accumulated
deficit primarily as a result of certain reserves and accruals not currently
deductible for tax purposes.

   Utilization of the net operating losses and credits may be subject to a
substantial annual limitation due to the ownership change limitations provided
by the Internal Revenue Code of 1986, as amended, and similar state provisions.
The annual limitation may result in the expiration of net operating losses and
credits before utilization.

   Deferred income taxes reflect the net tax effects of temporary differences
between the carrying amounts of assets and liabilities for financial reporting
purposes and the amounts used for income tax purposes. Significant components
of the Chemdex's deferred tax assets are as follows:

<TABLE>
<CAPTION>
                                                             December 31,
                                                         ----------------------
                                                           1997        1998
                                                         ---------  -----------
      <S>                                                <C>        <C>
      Deferred tax assets:
        Net operating loss carryforwards................ $ 157,000  $ 3,000,000
        Research credit carryforwards...................    13,000      200,000
        Reserves and accruals...........................     3,000      300,000
                                                         ---------  -----------
          Total deferred tax assets.....................   173,000    3,500,000
      Valuation Allowance...............................  (173,000)  (3,500,000)
                                                         ---------  -----------
      Net deferred tax assets........................... $     --   $       --
                                                         =========  ===========
</TABLE>

   Under FAS 109, Accounting for Income Taxes, deferred tax assets and
liabilities are determined based on differences between financial reporting and
tax bases of assets and liabilities and are measured using the enacted tax
rates and laws that will be in effect when the differences are expected to
reverse. Based upon the weight of available evidence, which includes Chemdex's
historical operating performance, the reported net losses for the period from
inception through December 31, 1997 and for the year ended December 31, 1998,
and the uncertainties regarding Chemdex's future results of operations, a full
valuation allowance has been provided against its net deferred tax assets. It
is more likely than not that the deferred tax assets will not be realized. The
valuation allowance increased by $173,000 for the period from inception through
December 31, 1997 and $3,327,000 during 1998.

9. Events Subsequent To Date Of Auditor's Report

 1999 Employee Stock Purchase Plan

   On May 11, 1999, Chemdex's Board of Directors approved, subject to
stockholder approval, the adoption of the 1999 Employee Stock Purchase Plan
(the "Purchase Plan"). A total of 750,000 shares of common stock has been
reserved for issuance under the 1999 Purchase Plan, as well as an automatic
annual increase on the first day of each of Chemdex's fiscal years beginning in
2000, 2001, 2002, 2003 and 2004 equal to the lesser of 200,000 shares, 1/2% of
Chemdex's outstanding common stock on the last day of the immediately preceding
fiscal year or a lesser number of shares determined by the Board of Directors.
Each offering period will consist of four consecutive purchase periods of six
months' duration. The initial offering period is expected to begin on the date
of this offering and end on July 31, 2001; the initial purchase period is
expected to end on January 31, 2000.

                                      F-26
<PAGE>

                              CHEMDEX CORPORATION

                   NOTES TO FINANCIAL STATEMENTS--(Continued)

        (Information as of March 31, 1999 and for the three months ended
                     March 31, 1998 and 1999 is unaudited)


   The Purchase Plan permits eligible employees to purchase common stock
through payroll deductions, which may not exceed 20% of an employee's
compensation, at a price equal to the lower of 85% of the fair market value of
Chemdex's common stock at the beginning of each offering period or at the end
of each purchase period. If not terminated earlier, the Purchase Plan has a
term of 20 years.

 Series C Preferred Stock

   In April 1999, Chemdex issued an additional 399,892 shares of Series C
preferred stock to investors, resulting in net proceeds of $2,286,063.

 Deferred Compensation

   In April 1999, Chemdex granted to employees options to purchase 594,780
shares of common stock at an exercise price of $5.00 per share. On May 17,
1999, June 2, 1999 and June 25, 1999 Chemdex granted a total of 978,396 shares
of common stock at an exercise price of $10.00 per share. We estimate that we
will record additional deferred compensation of approximately $2.5 million with
regard to the April 1999 grants.

 1998 Stock Plan

   On April 27, 1999, Chemdex's Board of Directors approved an increase in the
number of shares reserved for issuance under the 1998 Plan of 1,500,000 shares
and, on May 11, 1999 an additional increase of 1,250,000 shares. The 1998 Plan
was also amended to provide for automatic annual increases on the first day of
each fiscal year beginning in 2000, 2001, 2002, 2003 and 2004 equal to the
lesser of 1,250,000 shares, 3% of Chemdex's outstanding common stock on the
last day of the immediately preceding fiscal year or a lesser number of shares
as determined by the Board of Directors.

 Authorization of Shares

   On May 11, 1999, Chemdex's Board of Directors authorized 175,000,000 shares
of common stock and 2,500,000 shares of preferred stock, each with a par value
of $.0002 per share, effective in connection with this offering. The preferred
stock may be issued from time to time in one or more series. The Board of
Directors has the authority, within the limitations and restrictions in the
certificate of incorporation, to provide by resolution for the issuance of
shares of preferred stock in one or more series and to fix the rights,
preferences, privileges and restrictions thereof, including dividend rights,
dividend rates, conversion rights, voting rights, terms of redemption,
redemption prices, liquidation preferences and the number of shares
constituting any series or the designation of such series, without further vote
or action by the stockholders.

 1999 Directors' Plan

   On May 11, 1999, Chemdex's Board of Directors approved, subject to
stockholder approval, the 1999 Directors' Stock Plan (the "Directors' Plan"). A
total of 250,000 shares of common stock has been reserved under the Directors'
Plan.

 BIO Agreement

   In May 1999, the Biotechnology Industry Organization (BIO) selected Chemdex
as its preferred supplier of e-commerce purchasing solutions. As a result, we
entered into a five-year, exclusive joint marketing

                                      F-27
<PAGE>

                              CHEMDEX CORPORATION

                   NOTES TO FINANCIAL STATEMENTS--(Continued)

        (Information as of March 31, 1999 and for the three months ended
                     March 31, 1998 and 1999 is unaudited)

agreement with BIO. As part of the joint marketing agreement, Chemdex will
discount the fees we charge to BIO members for our solution and will contribute
cash payments to a joint marketing fund, to be used in connection with both
parties' obligations under the joint marketing agreement. In addition, we sold
187,500 shares of our common stock to BIO for a nominal amount in consideration
for BIO's participation in these joint marketing activities. BIO has the right
to use a portion of the cash payments and any proceeds it receives from the
sale of the common stock for the benefit of its members and the biotechnology
industry. The charge for BIO marketing activities will be expensed to sales and
marketing as they are incurred. We will also record the difference between the
nominal amount per share price paid by BIO for the purchase of our common stock
and the fair value as of the date of issuance, which is approximately $1.8
million, ratably over the five-year term of the joint marketing agreement.

 VWR Agreement

   In March 1999, Chemdex entered into a strategic relationship agreement with
VWR, which was consummated in April 1999, pursuant to which Chemdex and VWR
agreed to market jointly VWR laboratory products using the Chemdex Marketplace.
The term of the agreement is four years.

   The agreement gives Chemdex the right to offer approximately 350,000 VWR-
distributed products to Chemdex customers and both parties agreed to jointly
develop an online purchasing solution for VWR's existing customers. In
connection with the strategic relationship agreement, VWR transferred to
Chemdex information concerning VWR customers who purchased products from third
party suppliers outside VWR's primary product offering and Chemdex issued
2,538,405 shares of common stock valued at $13.9 million to VWR.

   We intend to use this information to expand sales of our purchasing solution
to these customers and adoption of the Chemdex Marketplace by these customers
and suppliers. The fair value of the common stock of $13.9 million will be
allocated to the customer list and will be amortized into sales and marketing
expense over four years, the estimated useful life of this intangible asset.

 Reverse Stock Split

   On June 28, 1999, the Company's Board of Directors approved a one-for-two
reverse stock split of the Company's common and preferred stock. On July 23,
1999 the reverse stock split became effective. In addition, the par value of
the common stock was changed to $.0002 per share. All share and per share
amounts in the accompanying financial statements have been adjusted
retroactively.

                                      F-28
<PAGE>

                               PROMEDIX.COM, INC.

<TABLE>
<CAPTION>
                                                                            Page
                                                                            ----
<S>                                                                         <C>
Report of Ernst & Young LLP, Independent Auditors.......................... F-30

Balance Sheets............................................................. F-31

Statements of Operations................................................... F-32

Statements of Common Shareholders' Equity (Deficit)........................ F-33

Statements of Cash Flows................................................... F-34

Notes to Financial Statements.............................................. F-35
</TABLE>

                                      F-29
<PAGE>

                         REPORT OF INDEPENDENT AUDITORS

Board of Directors
Promedix.com, Inc.

   We have audited the accompanying balance sheets of Promedix.com, Inc. as of
December 31, 1997 and 1998, and the related statements of operations, common
shareholders' equity (deficit), and cash flows for the years then ended. These
financial statements are the responsibility of the Company's management. Our
responsibility is to express an opinion on these financial statements based on
our audits.

   We conducted our audits in accordance with generally accepted auditing
standards. Those standards require that we plan and perform the audit to obtain
reasonable assurance about whether the financial statements are free of
material misstatement. An audit includes examining, on a test basis, evidence
supporting the amounts and disclosures in the financial statements. An audit
also includes assessing the accounting principles used and significant
estimates made by management, as well as evaluating the overall financial
statement presentation. We believe that our audits provide a reasonable basis
for our opinion.

   In our opinion, the financial statements referred to above present fairly,
in all material respects, the financial position of Promedix.com, Inc. at
December 31, 1997 and 1998, and the results of its operations and its cash
flows for the years then ended in conformity with generally accepted accounting
principles.

                                                               Ernst & Young LLP
Salt Lake City, Utah
October 15, 1999

                                      F-30
<PAGE>

                               PROMEDIX.COM, INC.

                                 BALANCE SHEETS

<TABLE>
<CAPTION>
                                                December 31,
                                            ---------------------  September 30,
                                              1997        1998         1999
                                            ---------  ----------  -------------
                                                                    (unaudited)
<S>                                         <C>        <C>         <C>
Assets
Current Assets:
  Cash and cash equivalents...............  $     127  $3,002,148  $    987,367
  Accounts receivable, less allowance of
   $2,710, $0 and $43,052, respectively...     16,668         --      2,143,092
  Inventories.............................        --          --      1,931,066
  Notes receivable from related parties...        --          --        217,397
  Other current assets....................        --       30,000        99,535
                                            ---------  ----------  ------------
Total current assets......................     16,795   3,032,148     5,378,457
Property and equipment, net...............      3,001       2,252     1,206,340
Intangible assets.........................        --          --      2,495,438
Other non-current assets..................        --          --         77,992
                                            ---------  ----------  ------------
Total assets..............................  $  19,796  $3,034,400  $  9,158,227
                                            =========  ==========  ============
Liabilities and shareholders' equity
 (deficit)
Current liabilities:
  Accounts payable........................  $  13,200  $   10,944  $  1,727,957
  Accrued liabilities.....................        --       17,526       138,584
  Accrued compensation....................        --          786       349,638
  Deferred revenue........................      7,236         --            --
  Due to related parties..................     20,160       2,000           --
  Short-term debt.........................        --          --      1,531,692
  Subordinated convertible notes, net of
   $2,699,163 discount ...................        --          --      2,300,672
                                            ---------  ----------  ------------
Total current liabilities.................     40,596      31,256     6,048,543
Commitments
Preferred Stock--Series A.................        --    3,001,597     3,738,057
Shareholders' equity (deficit)
  Common stock; $.0001 value; 10,000,000,
   15,500,000 and 25,000,000 shares
   authorized, respectively; 2,100,760,
   3,446,250, 3,546,250 issued and
   outstanding, respectively .............        210         345           355
  Additional paid in capital..............    119,866     133,306    23,934,249
  Deferred compensation...................        --          --    (17,624,990)
  Accumulated deficit.....................   (140,876)   (132,104)   (6,937,987)
                                            ---------  ----------  ------------
Total shareholders' equity (deficit)......    (20,800)      1,547     (628,373)
                                            ---------  ----------  ------------
Total liabilities and shareholders' equity
 (deficit)................................  $  19,796  $3,034,400  $  9,158,227
                                            =========  ==========  ============
</TABLE>

                            See accompanying notes.

                                      F-31
<PAGE>

                               PROMEDIX.COM, INC.

                            STATEMENTS OF OPERATIONS

<TABLE>
<CAPTION>
                                      Year Ended          Nine Months Ended
                                     December 31,           September 30,
                                  --------------------  ----------------------
                                    1997       1998       1998        1999
                                  ---------  ---------  ---------  -----------
                                                             (unaudited)
<S>                               <C>        <C>        <C>        <C>
Revenues........................  $ 197,249  $  14,034  $  14,034  $ 7,875,993
Cost of revenues................     55,542      1,100      1,100    5,776,465
                                  ---------  ---------  ---------  -----------
Gross profit....................    141,707     12,934     12,934    2,099,528
Operating expenses:
  Sales and marketing...........     30,596        --         --     1,574,886
  General and administrative....    246,306     73,236     66,498    3,063,818
  Research and development......        --         --         --       118,568
  Amortization of deferred
   compensation.................        --         --         --     3,776,288
  Amortization of intangible
   assets.......................        --         --         --       202,332
                                  ---------  ---------  ---------  -----------
Total operating expenses........    276,902     73,236     66,498    8,735,892
                                  ---------  ---------  ---------  -----------
Loss from operations............   (135,195)   (60,302)   (53,564)  (6,636,364)
Other income (expense):
  Other income (expense)........    (5,465)        --          (5)      (4,963)
  Interest expense..............       (316)       --         --      (236,603)
  Interest income...............        100        398        --        82,047
                                  ---------  ---------  ---------  -----------
Loss before provision for income
 taxes..........................   (140,876)   (59,904)   (53,569)  (6,795,883)
  Provision for income taxes....        --         --         --       (10,000)
                                  ---------  ---------  ---------  -----------
Loss before extraordinary item..   (140,876)   (59,904)   (53,569)  (6,805,883)
  Extraordinary item............        --      86,204     86,204          --
                                  ---------  ---------  ---------  -----------
Net income (loss)...............  $(140,876) $  26,300  $  32,635  $(6,805,883)
                                  =========  =========  =========  ===========
Basic Net income (loss) per
 share
  Loss before extraordinary item
   .............................  $   (0.10) $   (0.02) $   (0.02) $     (1.94)
                                  =========  =========  =========  ===========
  Extraordinary item............  $     --   $    0.03  $    0.03  $       --
                                  =========  =========  =========  ===========
  Net income (loss).............  $   (0.10) $    0.01  $    0.01  $     (1.94)
                                  =========  =========  =========  ===========
Diluted Net income (loss) per
 share
  Loss before extraordinary item
   .............................  $   (0.10) $   (0.01) $   (0.02) $     (1.94)
                                  =========  =========  =========  ===========
  Extraordinary item............  $     --   $    0.01  $    0.03  $       --
                                  =========  =========  =========  ===========
  Net income (loss).............  $   (0.10) $     --   $    0.01  $     (1.94)
                                  =========  =========  =========  ===========
Weighted average number of
 shares outstanding:
  Basic.........................  1,379,988  2,696,228  2,447,544    3,502,209
  Diluted.......................  1,379,988  6,693,028  2,447,544    3,502,209
</TABLE>

                            See accompanying notes.

                                      F-32
<PAGE>

                               PROMEDIX.COM, INC.

              STATEMENTS OF COMMON SHAREHOLDERS' EQUITY (DEFICIT)

<TABLE>
<CAPTION>
                            Common Stock    Additional
                          -----------------   Paid In     Deferred    Accumulated
                           Shares    Amount   Capital   Compensation    Deficit       Total
                          ---------  ------ ----------- ------------  -----------  -----------
<S>                       <C>        <C>    <C>         <C>           <C>          <C>
Balance at December 31,
 1996...................  1,000,000   $100  $     9,900 $        --   $       --   $    10,000
Issuance of stock for
 cash and other.........  1,100,760    110      109,966          --           --       110,076
Net loss................        --     --           --           --      (140,876)    (140,876)
                          ---------   ----  ----------- ------------  -----------  -----------
Balance at December 31,
 1997...................  2,100,760    210      119,866          --      (140,876)     (20,800)
Issuance of stock for
 cash and other ........  1,357,570    136       13,439          --           --        13,575
Accretion of preferred
 stock..................        --     --           --           --       (17,528)     (17,528)
Cancellation of common
 stock..................    (12,080)    (1)           1          --           --           --
Net income..............        --     --           --           --        26,300       26,300
                          ---------   ----  ----------- ------------  -----------  -----------
Balance at December 31,
 1998...................  3,446,250    345      133,306          --      (132,104)       1,547
Issuance of stock for
 cash (unaudited).......    100,000     10        9,990          --           --        10,000
Deferred compensation
 relating to stock
 options (unaudited)....        --     --    21,401,278  (21,401,278)         --           --
Amortization of deferred
 compensation relating
 to stock options
 (unaudited)............        --     --           --     3,776,288          --     3,776,288
Issuance of warrants for
 Pro Med Co.
 (unaudited)............        --     --     2,389,675          --           --     2,389,675
Net loss (unaudited)....        --     --           --           --    (6,805,883)  (6,805,883)
                          ---------   ----  ----------- ------------  -----------  -----------
Balance at September 30,
 1999 (unaudited).......  3,546,250   $355  $23,934,249 $(17,624,990) $(6,937,987) $  (628,373)
                          =========   ====  =========== ============  ===========  ===========
</TABLE>


                            See accompanying notes.

                                      F-33
<PAGE>

                               PROMEDIX.COM, INC.

                            STATEMENTS OF CASH FLOWS

<TABLE>
<CAPTION>
                                       Year Ended         Nine Months Ended
                                      December 31,          September 30,
                                  ---------------------  ---------------------
                                    1997        1998       1998       1999
                                  ---------  ----------  --------  -----------
                                                             (unaudited)
<S>                               <C>        <C>         <C>       <C>
Operating Activities
Net income (loss)...............  $(140,876) $   26,300  $ 32,635  $(6,805,883)
Adjustments to reconcile net
 loss to net cash used in
 operating activities:
  Depreciation and
   amortization.................        749         749       562       98,546
  Amortization of intangible
   assets.......................        --          --        --       202,332
  Amortization of deferred
   compensation.................        --          --        --     3,776,288
  Non-cash legal expense........        --          --        --       711,460
  Non-cash interest expense.....        --          --        --       179,817
  Forgiveness of debt...........        --      (86,204)  (86,204)         --
Changes in operating assets and
 liabilities:
  Accounts receivable...........    (16,668)     16,668    14,591     (256,401)
  Inventories...................        --          --        --       126,415
  Other current assets..........     10,000     (30,000)  (30,000)      (4,717)
  Other assets..................        --          --        --       (60,892)
  Accounts payable..............     13,200      (2,256)   (4,478)     421,252
  Accrued liabilities...........      7,236      10,290    (7,236)     (31,891)
  Accrued compensation..........        --          786       --       204,018
                                  ---------  ----------  --------  -----------
    Net cash used in operating
     activities.................   (126,359)    (63,667)  (80,130)  (1,439,656)
                                  ---------  ----------  --------  -----------
Investing Activities:
  Investment in subsidiary......        --          --        --      (536,920)
  Sale of fixed assets..........        --          --        --       983,626
  Purchases of property and
   equipment....................     (3,750)        --        --    (1,108,534)
                                  ---------  ----------  --------  -----------
    Net cash used in investing
     activities.................     (3,750)        --        --      (661,828)
                                  ---------  ----------  --------  -----------
Financing Activities:
  Borrowings on line of credit,
   net..........................        --          --        --       838,092
  Borrowing on short-term
   notes........................     20,160      68,044    68,044          --
  Payment on notes payable......        --          --        --      (786,389)
  Net proceeds from issuance of
   preferred stock..............        --    2,984,069       --        25,000
  Proceeds from issuance of
   common stock.................    110,076      13,575    13,000       10,000
                                  ---------  ----------  --------  -----------
    Net cash provided by
     financing activities.......    130,236   3,065,688    81,044       86,703
                                  ---------  ----------  --------  -----------
Net increase (decrease) in cash
 and cash equivalents...........        127   3,002,021       914   (2,014,781)
Cash and cash equivalents at
 beginning of period............        --          127       127    3,002,148
                                  ---------  ----------  --------  -----------
Cash and cash equivalents at end
 of period......................  $     127  $3,002,148  $  1,041  $   987,367
                                  =========  ==========  ========  ===========
Supplemental Disclosure of Cash
 Flow Information:
 Cash paid during the period for
  interest......................  $     316  $      --   $    --   $    46,786
 Cash paid during the period for
  income taxes..................  $     --   $      --   $    --   $   107,000
Non cash investing and financing
 activities:
 Investment in subsidiary for
  subordinated convertible note
  payable.......................                                   $ 4,510,530
 Discount to subordinated
  convertible note payable for
  value ascribed to warrants....                                   $ 2,389,675
 Deferred compensation
  associated with issuance of
  stock options.................                                   $21,401,278
</TABLE>

                            See accompanying notes.

                                      F-34
<PAGE>

                               PROMEDIX.COM, INC.

                         NOTES TO FINANCIAL STATEMENTS

 (Information as of September 30, 1999 and for the nine months ended September
                        30, 1998 and 1999 is unaudited)

1.Description of Business

   Promedix.com, Inc. ("Promedix") (originally named MCA HealthPages, Inc.) was
incorporated on December 20, 1996. During 1997, Promedix pursued a strategy of
providing web design and hosting services for specialty medical equipment
manufacturers. This strategy was terminated in early 1998, and Promedix then
began pursuing its present e-commerce activities.

   Promedix is a provider of e-commerce solutions to the specialty medical
products market. Promedix enables health care enterprises and suppliers to
efficiently buy and sell specialty medical products through the Promedix
marketplace, a secure, Internet-based purchasing solution. Promedix acquired
Pro Med Co., Inc., ("Pro Med Co.") a specialty medical fulfillment business, in
May 1999.

   Promedix's e-commerce business is currently in development. During this
period, operating activities relate primarily to the design and development of
Promedix's online marketplace and corporate infrastructure and the
establishment of relationships with suppliers and customers. Promedix has
incurred operating losses to date and had an accumulated deficit of
approximately $6.9 million at September 30, 1999. Promedix's activities have
been financed through private placements of equity securities. Promedix has
obtained a commitment from an investor to provide funding for its operational
requirements for the next calendar year.

   On September 21, 1999, Promedix signed a definitive agreement in which all
of its outstanding shares will be acquired by Chemdex Corporation ("Chemdex").
Closing of the transaction is expected to occur by January, 2000 (see Note 12).

2.Summary of Significant Accounting Policies

 Use of Estimates

   The preparation of financial statements in conformity with generally
accepted accounting principles requires management to make estimates and
assumptions that affect the amounts reported in the financial statements and
accompanying notes. Actual results could differ from those estimates.

 Interim Financial Information

   The financial information as of September 30, 1999 and for the nine months
ended September 30, 1998 and 1999 is unaudited and includes all adjustments,
consisting only of normal recurring adjustments, that Promedix's management
considers necessary for a fair presentation of Promedix's operating results and
cash flows for the period. Results for the nine month period ended September
30, 1999 are not necessarily indicative of results to be expected for the full
fiscal year of 1999 or for any future period.

 Revenue Recognition

   During 1997 and 1998, revenues consisted primarily of service and renewal
fees charged to medical manufacturers which utilized the company's website
design and hosting services, which were recorded as revenues when the services
were provided.

   Beginning in May 1999, Promedix's revenues include fulfillment revenues
generated from the distribution of medical products and equipment by Pro Med
Co., which are recorded as revenues when the products and equipment are
shipped.


                                      F-35
<PAGE>

                               PROMEDIX.COM, INC.

                   NOTES TO FINANCIAL STATEMENTS--(Continued)

      (Information as of September 30, 1999 and for the nine months ended
                   September 30, 1998 and 1999 is unaudited)

 Cash and Cash Equivalents

   Cash equivalents consist of financial instruments which are readily
convertible to cash and have original maturities of three months or less at the
time of acquisition. Promedix's cash and cash equivalents, as of December 31,
1997 and 1998 and September 30, 1999, consisted primarily of cash and money
market funds held by financial institutions in the United States, and had
carrying values which approximated fair value.

 Property and Leasehold Improvements

   Promedix records property and equipment at cost and calculates depreciation
using the straight-line method over estimated useful lives of five to ten
years.

 Inventories

   Inventories consist primarily of medical products and equipment.
Inventories, net of allowances, are valued at the lower of cost or market value
with cost being determined using the average cost method.

 Intangible Assets

   The intangible assets recorded by the Company in connection with the
acquisition of Pro Med Co. (See Note 4) are being amortized on a straight-line
basis. As of September 30, 1999, accumulated amortization of intangible assets
amounted to $202,332. The intangible assets are being amortized over five
years.

 Stock-Based Compensation

   Promedix has elected to follow Accounting Principles Board Opinion No. 25,
Accounting for Stock Issued to Employees, ("APB Opinion No. 25"), and related
interpretations in accounting for its employee stock options and adopted the
disclosure only provisions of Statement of Financial Accounting Standards No.
123, Accounting for Stock-Based Compensation. Under APB Opinion No. 25, when
the exercise price of Promedix's employee stock options equals the market price
of the underlying stock on the date of grant, no compensation expense is
recognized.

 Earnings Per Share

   Basic earnings per share is computed using the weighted average number of
shares outstanding. Diluted earnings per share is computed using the weighted
average number of shares outstanding adjusted for the incremental shares
attributed to outstanding stock options, warrants and convertible securities.
Because of the net loss, the computation of basic and diluted earnings per
share is the same for the year ended December 31, 1997 and for the nine months
ended September 30, 1999. The incremental shares used for the year ended
December 31, 1998 was 3,996,800 related to the assumed conversion of preferred
stock.

3. Concentrations of Credit Risk and Other Risks

   Financial instruments that potentially subject Promedix to credit risk
consist primarily of uninsured cash and cash equivalents. Cash and cash
equivalents are deposited with a federally insured commercial bank in the
United States.

   Promedix presently sells primarily to emergency medical service providers.
Promedix performs ongoing credit evaluations of its customers but does not
require collateral. Promedix analyzes the need for reserves for potential
credit losses and records reserves when necessary. These losses have been
within management's expectations. To date, Promedix has not had significant
write-offs of bad debt.

   For the year ended December 31, 1997 one customer accounted for 17% of net
revenues.

                                      F-36
<PAGE>

                               PROMEDIX.COM, INC.

                   NOTES TO FINANCIAL STATEMENTS--(Continued)

      (Information as of September 30, 1999 and for the nine months ended
                   September 30, 1998 and 1999 is unaudited)


4. Acquisition

   On May 18, 1999, Promedix acquired all the outstanding stock of Pro Med Co.
for $5,047,450 consisting of (i) $500,192 in cash (ii) $4,999,835 in face
amount of convertible subordinated promissory notes (discounted $2,878,980 to
reflect the value assigned to the warrants and the non-interest bearing period
of the notes) and (iii) warrants to purchase 333,334 shares of Promedix Series
B-1 preferred stock, valued at $2,389,675 for accounting purposes. Promedix
also incurred $36,728 in direct costs relating to the acquisition. The
acquisition was accounted for as a purchase, and Pro Med Co.'s results of
operations have been included in the accompanying unaudited September 30, 1999
consolidated financial statements since the acquisition date. Pro Med Co. is a
distributor of specialty medical products.

   The purchase price was allocated as follows:

<TABLE>
   <S>                                                             <C>
   Current assets................................................. $ 3,402,438
   Property and equipment.........................................   1,177,726
   Other assets...................................................      17,100
   Goodwill.......................................................   2,725,067
   Current liabilities............................................  (1,510,840)
   Long-term liabilities..........................................    (764,041)
                                                                   -----------
   Purchase price................................................. $ 5,047,450
                                                                   ===========
</TABLE>

   In connection with the pending merger of Promedix with Chemdex, Promedix has
entered into an agreement to sell Pro Med Co. to an unrelated third party (see
Note 12).

5. Property and Equipment

   Property and equipment consist of the following:

<TABLE>
<CAPTION>
                                    Estimated    December 31,
                                   Useful Lives ---------------  September 30,
                                     in Years    1997    1998        1999
                                   ------------ ------  -------  -------------
   <S>                             <C>          <C>     <C>      <C>
   Furniture and fixtures.........    5 to 7    $  --   $   --    $  206,502
   Machinery and equipment........      7          --       --       987,445
   Office equipment...............      5        3,750    3,750        3,750
   Leasehold improvements.........      10         --       --       108,677
                                                ------  -------   ----------
                                                 3,750    3,750    1,306,384
   Less--accumulated depreciation
    and amortization..............                (749)  (1,498)    (100,044)
                                                ------  -------   ----------
   Property and equipment, net....              $3,001  $ 2,252   $1,206,340
                                                ======  =======   ==========
</TABLE>

6. Commitments

   During 1999, Promedix has entered into 11 lease agreements to lease office
and warehouse space, as well as office equipment and furniture. These leases
have initial payment terms beginning at approximately $50,000 per month in the
aggregate, and expire at various dates through October 2004.

   There were no lease commitments as of December 31, 1998.

                                      F-37
<PAGE>

                               PROMEDIX.COM, INC.

                   NOTES TO FINANCIAL STATEMENTS--(Continued)

      (Information as of September 30, 1999 and for the nine months ended
                   September 30, 1998 and 1999 is unaudited)


   Rental expense for the years ended December 31, 1997 and 1998 was $13,500
and $825, respectively. Rental expense for the nine months ended September 30,
1999 was $107,984.

   Promedix has entered into agreements during 1999 with two companies to
provide public relations and advertising services for payments of approximately
$26,000 per month and the issuance of 1,500 stock options. These agreements are
cancelable by either party with 60 days notice.

7. Financing Arrangements

   In connection with the proposed Chemdex merger, Chemdex agreed to provide
Promedix a $10 million line of credit (see Note 12).

   In May 1999, in connection with the acquisition of Pro Med Co., Promedix
issued subordinated convertible promissory notes in the aggregate amount of
$4,999,835. These notes bear interest at 8% beginning September 2000 and are
secured by the common stock of Pro Med Co. The notes are partially convertible
into equity securities of Promedix upon the occurrence of a new equity
financing or within 12 months from the date of issuance. In November 1999, the
noteholders agreed to convert $1.0 million of the notes into 346,020 shares of
Promedix Series B-2 preferred stock. The notes original maturity date is
December 2005, which can be accelerated upon certain events, including a change
in control of Promedix. Accordingly, in connection with the proposed Chemdex
merger (see Note 12), the unpaid principal balance is expected to be paid upon
closing of the Chemdex transaction. The notes were issued with an original
discount of $2,878,980 to reflect the value assigned to the warrants issued in
connection with the Pro Med Co. acquisition and the non-interest bearing period
of the notes.

   On July 14, 1999, Pro Med Co. entered into a line of credit with a bank
which provides for borrowings of up to $2,500,000 with interest at the bank's
prime rate plus 0.25%. Borrowings under the line are secured by substantially
all of Pro Med Co.'s assets. Amounts under the line are due July 2000.

8. Stockholders' Equity

 Convertible Preferred Stock

   Convertible preferred stock at December 31, 1998, and September 30, 1999, is
as follows:

<TABLE>
<CAPTION>
                                              Shares Issued and Outstanding
            Liquidation Shares Authorized  ------------------------------------
            Preference  September 30, 1999 December 31, 1998 September 30, 1999
            ----------- ------------------ ----------------- ------------------
<S>         <C>         <C>                <C>               <C>
Series A...   $0.751        4,030,089          3,996,800         4,030,089
Series B-
 1.........   $1.500          333,334                --                --
Series B-
 2.........   $2.890          346,020                --                --
Series C...   $28.34        1,000,000                --                --
</TABLE>

   The Series A, Series B-1 and Series B-2 preferred stock is redeemable at the
option of the holders on or after December 29, 2004, in an amount equal to
$0.751 per share for the Series A, $1.50 per share for the Series B-1 and $2.89
per share for the Series B-2 preferred stock.

                                      F-38
<PAGE>

                               PROMEDIX.COM, INC.

                   NOTES TO FINANCIAL STATEMENTS--(Continued)

      (Information as of September 30, 1999 and for the nine months ended
                   September 30, 1998 and 1999 is unaudited)


   Series A, B-1, B-2 and C preferred stock is convertible, at the option of
the holder, into one share of common stock, subject to certain adjustments for
dilutive issuances. Any outstanding shares of Series A, B-1, B-2 and C
preferred stock automatically convert into common stock upon a firm commitment
underwritten public offering of Promedix's common stock with gross proceeds to
Promedix of at least $10,000,000 and a per share price of at least $5.257.

   Holders of Series A, B-1, B-2 and C preferred stock are entitled to receive
dividends only when declared by the Board of Directors out of legally available
funds. No dividends have been declared or accrued as of September 30, 1999.

   Series A, B-1, B-2 and C preferred stockholders are entitled to receive,
upon a Liquidating Event, an amount per share equal to the issuance price, plus
all declared but unpaid dividends. The remaining assets and funds, if any,
shall be distributed among the holders of Series A, B-1, B-2 and C preferred
stock and common stock pro rata based on the number of shares of common stock
held by each (assuming conversion of all such Series A, B-1, B-2 and C
preferred stock). If any assets remain after the holders of Series A, B-1, B-2
and C preferred stock have received an aggregate of $0.751, $1.50, $2.89 and
$28.34 per share, the remaining assets will be distributed to the holders of
the common stock pro rata based on the number of shares common stock held by
each.

   On September 21, 1999, Promedix entered into an agreement to issue 176,429
shares of its Series C preferred stock for $28.34 per share, with a closing
scheduled to occur December 22, 1999.

 Warrants

   In May 1999, in connection with the acquisition of Pro Med Co., Promedix
issued fully vested warrants that entitles the holder to purchase 333,334
shares of the Promedix's Series B-1 preferred stock at an exercise price of
$1.50 per share. These warrants are exercisable through the earlier of (a) the
closing of an equity financing resulting in proceeds of at least $2,000,000;
(b) the sale of the company or change in control, as defined, or (c) the
closing of an underwritten public offering.

 Common Stock

   Each share of common stock is entitled to one vote. The holders of common
stock are also entitled to receive dividends from legally available funds when
and if declared by the Board of Directors, subject to the prior rights of
holders of Series A, B-1, B-2 and C preferred stock.

   At September 30, 1999, common stock was reserved for future issuance as
follows:

<TABLE>
   <S>                                                                 <C>
   Conversion of Series A preferred stock............................. 4,030,089
   Conversion of Series B-1 preferred stock...........................   333,334
   Conversion of Series B-2 preferred stock...........................   346,020
   Conversion of Series C preferred stock............................. 1,000,000
   Stock Option Plan.................................................. 1,770,000
</TABLE>

   During the first quarter of 1999, Promedix adjusted its capital structure to
effect a 10:1 stock split and to change its capital stock from no par value to
$.0001 per share par value. The impact of these adjustments has been applied
retroactively to all periods presented.

   During 1998, a stockholder requested that Promedix cancel its 12,080 shares
of Promedix common stock. Accordingly, these shares have been removed from
Promedix's outstanding shares.

                                      F-39
<PAGE>

                               PROMEDIX.COM, INC.

                   NOTES TO FINANCIAL STATEMENTS--(Continued)

      (Information as of September 30, 1999 and for the nine months ended
                   September 30, 1998 and 1999 is unaudited)


 Stock Option Plan

   In December 1998, the Board of Directors adopted the 1998 Stock Plan (the
"1998 Plan") for issuance of common stock to eligible participants. The Plan
provides for the granting of incentive stock options and non-qualified stock
options. Incentive stock options and non-qualified stock options may be granted
under the 1998 Plan at prices not less than 100% and 85% of the fair value at
the date of grant, or at prices not less than 110% for individuals owning more
than 10% of the combined voting power of all classes of stock at the date of
grant. Options generally expire after ten years.

   Activity under the 1998 Stock Plan is as follows:

<TABLE>
<CAPTION>
                                                       Options Outstanding
                                              ---------------------------------------
                             Shares Available Number of   Price per  Weighted-Average
                                for Grant      Shares       Share     Exercise Price
                             ---------------- ---------  ----------- ----------------
   <S>                       <C>              <C>        <C>         <C>
   Authorized..............      1,870,000
   Granted.................     (1,297,761)   1,297,761  $.10-$15.00       $.58
   Exercised...............            --      (100,000) $.10              $.10
   Canceled................          2,500          --   $.10-$1.00        $.64
                                ----------    ---------
   Balance at September 30,
    1999...................        574,739    1,197,761  $.10-$15.00       $.62
                                ==========    =========
</TABLE>

   In connection with the grant of share options to employees through September
30, 1999, Promedix recorded deferred compensation of $21,401,278 for the
aggregate differences between the exercise price of options at their dates of
grant and deemed fair value for accounting purposes of the common shares
subject to these options. Such amount is included as a reduction of
stockholders' equity and is being amortized on a straight-line vesting method
over the option vesting periods, which are generally four years. The
compensation expense of $3,776,288 through September 30, 1999 relates to the
options awarded to employees in all operating expense categories.

9. Employee Savings and Retirement Plan

   Beginning May 1999, Promedix has a 401(K) plan that allows eligible
employees to contribute up to 15% of their salary, subject to annual limits.
Under the Plan, eligible employees may defer a portion of their pretax salaries
but not more than statutory limits. Promedix made $9,505 in contributions
during the nine months ended September 30, 1999.

10. Income Taxes

   The difference between the amount of income tax benefit recorded and the
amount of income tax benefit calculated using the federal statutory rate of 34%
is due to net operating losses having a valuation allowance, due to past
operating results and uncertainties regarding Promedix's future results of
operations. Accordingly, there is no provision for income taxes for the years
ended December 31, 1997 and 1998. The tax provision for the nine months ended
September 30, 1999 is for state income taxes.

                                      F-40
<PAGE>

                               PROMEDIX.COM, INC.

                   NOTES TO FINANCIAL STATEMENTS--(Continued)

      (Information as of September 30, 1999 and for the nine months ended
                   September 30, 1998 and 1999 is unaudited)


   As of December 31, 1998 Promedix had federal and state net operating loss
carry-forwards of approximately $112,000 for each which will expire through
2012 if not utilized.

   Utilization of the net operating losses may be subject to a substantial
annual limitation due to the ownership change limitations provided by the
Internal Revenue Code of 1986, as amended, and similar state provisions. The
annual limitation may result in the expiration of net operating losses before
utilization.

   Deferred income taxes reflect the net tax effects of temporary differences
between the carrying amounts of assets and liabilities for financial reporting
purposes and the amounts used for income tax purposes. Significant components
of the Promedix deferred tax assets are as follows:

<TABLE>
<CAPTION>
                                                               December 31,
                                                             ------------------
                                                               1997      1998
                                                             --------  --------
   <S>                                                       <C>       <C>
   Deferred tax assets:
     Net operating loss carryforwards....................... $ 48,270  $ 41,880
     Reserves and accruals..................................    3,990       --
     Other..................................................     (280)      --
                                                             --------  --------
       Total deferred tax assets............................   51,980    41,880
   Deferred tax liability:
     Depreciation...........................................      --       (180)
                                                             --------  --------
   Net deferred tax asset...................................   51,980    41,700
   Valuation Allowance......................................  (51,980)  (41,700)
                                                             --------  --------
   Net deferred tax assets.................................. $    --   $    --
                                                             ========  ========
</TABLE>

   Under FAS 109, Accounting for Income Taxes, deferred tax assets and
liabilities are determined based on differences between financial reporting and
tax bases of assets and liabilities and are measured using the enacted tax
rates and laws that will be in effect when the differences are expected to
reverse. Based upon the weight of available evidence, which includes Promedix's
historical operating performance, the reported net losses for the years ended
December 31, 1997 and 1998, and the uncertainties regarding Promedix's future
results of operations, a full valuation allowance has been provided against its
net deferred tax assets. The valuation allowance increased by $51,980 during
1997 and decreased by $10,280 during 1998.

11. Related Party Transactions

   Promedix has an aggregate of $200,000 in principal amount of notes
receivable from two of the officers of Pro Med Co. The notes bear interest at
9.5%, are unsecured and are due in full on January 15, 2000. The total amount
due from officers at September 30, 1999, was $217,397.

   During 1997 and 1998, certain shareholders provided services and advanced
funds to Promedix to meet certain operating requirements. The value of these
advances and services totaled $65,684 in 1997 and $13,575 in 1998. These
advances were converted to common stock during each of the respective years.

   During 1997 and 1998, Medical Companies Alliance, Inc. and/or its affiliates
("MCA") advanced funds to Promedix to pay certain operating and development
expenses. The total of these advances was $20,160 and $86,204 through December
31, 1997 and September 30, 1998, respectively. This debt was forgiven by MCA in
September 1998, and the gain is shown as an extraordinary item in the
accompanying statements of operations.

                                      F-41
<PAGE>

                               PROMEDIX.COM, INC.

                   NOTES TO FINANCIAL STATEMENTS--(Continued)

      (Information as of September 30, 1999 and for the nine months ended
                   September 30, 1998 and 1999 is unaudited)


12. Chemdex Transaction

 Merger Transaction

   On September 21, 1999, Promedix entered into an agreement involving the
merger of a wholly-owned subsidiary of Chemdex, with and into Promedix, which
will become a wholly-owned subsidiary of Chemdex pursuant to an Agreement and
Plan of Merger by and among Chemdex, the acquisition subsidiary and Promedix.
In the merger, each outstanding share of Promedix common stock, assuming the
conversion of all outstanding Promedix preferred stock into common stock, will
be converted into and represent the right to receive Chemdex common stock based
on an exchange ratio. Each outstanding option and warrant to purchase Promedix
common stock will be converted into an option or warrant, respectively, to
purchase shares of Chemdex common stock in accordance with the same exchange
ratio. The exchange ratio will be determined by dividing 12,057,366, the total
number of shares of Chemdex common stock to be issued as a result of this
merger by the number of shares of Promedix capital stock outstanding and
subject to outstanding options and warrants to purchase Promedix capital stock
as of the closing date.

   Consummation of the merger is subject to various conditions, including
approval of the merger agreement by a majority of the shareholders of Chemdex
common stock entitled to vote at the Chemdex special meeting and approval of
the merger agreement by the requisite majorities of the shares of Promedix
capital stock entitled to vote at the Promedix special meeting. The parties
have agreed to a reciprocal break up fee of $10 million payable under certain
conditions with regard to the termination of the merger.

 Line of Credit

   In connection with the proposed Chemdex merger, Chemdex agreed to provide
Promedix a $10 million line of credit, drawable ratably on the first day of
each month through March 1, 2000. The loan bears interest at 9% and is secured
by substantially all of Promedix's assets. The outstanding balance is due upon
the earlier of (i) September 21, 2000, in the event that the merger agreement
is terminated (ii) the sale of all or substantially all of the assets of
Promedix to any party other than Chemdex or its affiliates or (iii) December
31, 2000. Also, in the event Promedix receives additional financing over
$500,000, Promedix is required to pay 25% of the proceeds to reduce any amount
outstanding under the loan.

 Sale of Pro Med Co.

   On      , 1999 Promedix entered into a Share Acquisition Agreement pursuant
to which an unrelated third party will purchase, prior to the consummation of
the merger transaction with Chemdex, all of the outstanding shares of capital
stock of Pro Med Co., from Promedix, at a valuation determined through an
independent appraisal.

   All stock options held by employees (43 people) of Pro Med Co. will be
reduced by one half and such remaining options will immediately become 100%
vested upon the sale of Pro Med Co. Options held by two Pro Med Co. officers
will be reduced by two thirds and the remaining portion will become 100% vested
upon the sale of such subsidiary. Deferred compensation expense attributable to
these stock options will be adjusted upon completion of the sale.

                                      F-42
<PAGE>

                               PROMEDIX.COM, INC.

                   NOTES TO FINANCIAL STATEMENTS--(Continued)

      (Information as of September 30, 1999 and for the nine months ended
                   September 30, 1998 and 1999 is unaudited)


13. Segment Reporting

   During the year ended December 31, 1998 Promedix adopted Statement of
Financial Accounting Standards No. 131 "Disclosures about Segments of an
Enterprise and Related Information" which establishes standards for reporting
information regarding operating segments in annual financial statements and
requires selected information for those segments to be presented in interim
financial statements. For the years ended December 31, 1997 and 1998, Promedix
viewed operations as principally one segment which provided website design and
internet hosting services.

   During 1999, Promedix began pursuing its present e-commerce activities and
acquired Pro Med Co., which is a distributor of medical products and equipment.

   During 1997 and 1998, revenue consisted primarily of service and renewal
fees charged to medical manufacturers which utilized the company's website
design and hosting. Beginning in May 1999, Promedix revenues include those
generated from the distribution of medical products and equipment by the
distribution company. There is no profit or loss on intersegment sales or
transfers.

<TABLE>
<CAPTION>
                                                    For the Nine Months
                                                 Ended September 30, 1999
                                            -----------------------------------
                                            Promedix.com Pro Med Co  Promedix
                                            ------------ ---------- -----------
<S>                                         <C>          <C>        <C>
Total assets...............................  $5,441,256  $4,806,570 $10,247,826
Net revenues...............................         --    7,875,993   7,875,993
Net income/(loss)..........................  (7,011,051)    205,168  (6,965,883)
</TABLE>

                                      F-43
<PAGE>

                               PRO MED CO., INC.

                         INDEX TO FINANCIAL STATEMENTS

<TABLE>
<S>                                                                         <C>
Report of Jones, Jensen & Company, Independent Auditors.................... F-45

Balance Sheets............................................................. F-46

Statements of Operations................................................... F-47

Statements of Stockholders' Equity......................................... F-48

Statements of Cash Flows................................................... F-49

Notes to Financial Statements.............................................. F-50
</TABLE>

                                      F-44
<PAGE>

                          INDEPENDENT AUDITORS' REPORT

Board of Directors
Pro Med Co., Inc.,
West Jordan, Utah

   We have audited the accompanying balance sheets of Pro Med Co., Inc., as of
December 31, 1998 and 1997 and the related statements of operations,
stockholders' equity and cash flows for the years then ended. These financial
statements are the responsibility of the Company's management. Our
responsibility is to express an opinion on these financial statements based on
our audits.

   We conducted our audits in accordance with generally accepted auditing
standards. Those standards require that we plan and perform the audits to
obtain reasonable assurance about whether the financial statements are free of
material misstatement. An audit includes examining, on a test basis, evidence
supporting the amounts and disclosures in the financial statements. An audit
also includes assessing the accounting principles used and significant
estimates made by management, as well as evaluating the overall financial
statement presentation. We believe that our audits provide a reasonable basis
for our opinion.

   In our opinion, the financial statements referred to above present fairly,
in all material respects, the financial position of Pro Med Co., Inc. as of
December 31, 1998 and 1997, and the results of its operations and its cash
flows for the years then ended in conformity with generally accepted accounting
principles.

Jones, Jensen & Company
Salt Lake City, Utah
January 28, 1999

                                      F-45
<PAGE>

                               PRO MED CO., INC.

                                 BALANCE SHEETS

<TABLE>
<CAPTION>
                                                              December 31,
                                                          ----------------------
                                                             1998        1997
                                                          ----------  ----------
<S>                                                       <C>         <C>
Assets
Current Assets
  Cash................................................... $      --   $      --
  Accounts receivable, net (Note 1)......................  1,945,968   2,109,519
  Inventory (Note 1).....................................  2,076,423   1,741,634
  Prepaids and other current assets......................     52,910      26,370
  Deferred tax benefit...................................     17,100      17,100
                                                          ----------  ----------
    Total Current Assets.................................  4,092,401   3,894,623
                                                          ----------  ----------
Fixed Assets (Notes 1 and 2).............................  1,074,015   1,133,653
                                                          ----------  ----------
    Total Assets......................................... $5,166,416  $5,028,276
                                                          ==========  ==========

Liabilities and Stockholders' Equity
Current Liabilities
  Cash overdraft......................................... $  258,274  $   92,255
  Line of credit (Note 7)................................    474,000     453,342
  Accounts payable.......................................  1,454,200   1,336,708
  Sales tax payable......................................     54,426      37,497
  Accrued expenses.......................................    176,611     143,300
  Taxes payable (Note 6).................................     76,281         --
  Capital lease--current portion (Note 4)................        --        8,412
  Notes payable--current portion (Note 3)................     20,348     552,415
                                                          ----------  ----------
    Total Current Liabilities............................  2,514,140   2,623,929
                                                          ----------  ----------
Long-term Debt
  Notes payable--long-term (Note 3)......................    770,821     788,728
                                                          ----------  ----------
    Total Long-Term Debt.................................    770,821     788,728
                                                          ----------  ----------
    Total Liabilities....................................  3,284,961   3,412,657
                                                          ----------  ----------
Stockholders' Equity
  Common stock, no par value, 100,000 shares
   authorized; 51,726 shares issued and outstanding......     55,384      55,384
  Notes receivable--related parties (Note 8).............   (203,167)        --
  Retained earnings......................................  2,029,238   1,560,235
                                                          ----------  ----------
    Total Stockholders' Equity...........................  1,881,455   1,615,619
                                                          ----------  ----------
  Total Liabilities And Stockholders' Equity............. $5,166,416  $5,028,276
                                                          ==========  ==========
</TABLE>

   The accompanying notes are an integral part of these financial statements

                                      F-46
<PAGE>

                               PRO MED CO., INC.

                            STATEMENTS OF OPERATIONS

<TABLE>
<CAPTION>
                                                          For the Years
                                                              Ended
                                                          December 31,
                                                     ------------------------
                                                        1998         1997
                                                     -----------  -----------
<S>                                                  <C>          <C>
Revenues
  Sales, net........................................ $19,355,059  $18,018,751
  Cost of sales.....................................  14,319,863   13,510,528
                                                     -----------  -----------
    Gross Profit....................................   5,035,196    4,508,223
Expenses
  Selling expenses..................................   2,926,183    2,533,426
  General and administrative........................   1,153,405    1,199,286
  Depreciation and amortization.....................      98,584       90,026
                                                     -----------  -----------
    Total Expenses..................................   4,178,172    3,822,738
                                                     -----------  -----------
Income From Operations..............................     857,024      685,485
                                                     -----------  -----------
Other Income (expense)
  Gain (loss) on sale of assets.....................         --           506
  Interest expense..................................    (148,971)    (149,546)
  Interest income...................................       3,167        1,230
  Other income......................................      25,442        5,430
                                                     -----------  -----------
    Total Other Income (Expense)....................    (120,362)    (142,380)
                                                     -----------  -----------
Income Before Provision For Income Taxes............     736,662      543,105
Provision For Income Taxes..........................    (267,659)    (208,500)
                                                     -----------  -----------
Net Income.......................................... $   469,003  $   334,605
                                                     ===========  ===========
Earnings Per Share--Basic and Diluted............... $      9.07  $      6.47
                                                     ===========  ===========
Weighted Average Shares Outstanding--Basic and
 Diluted............................................      51,726       51,726
                                                     ===========  ===========
</TABLE>


   The accompanying notes are an integral part of these financial statements

                                      F-47
<PAGE>

                               PRO MED CO., INC.

                       STATEMENTS OF STOCKHOLDERS' EQUITY

<TABLE>
<CAPTION>
                                                       Common Stock
                                                      --------------  Retained
                                                      Shares Amount   Earnings
                                                      ------ ------- ----------
<S>                                                   <C>    <C>     <C>
Balance, December 31, 1996........................... 51,726 $55,384 $1,225,630
Net income for the year ended December 31, 1997......    --      --     334,605
                                                      ------ ------- ----------
Balance, December 31, 1997........................... 51,726  55,384  1,560,235
Net income for the year ended December 31, 1998......    --      --     469,003
                                                      ------ ------- ----------
Balance, December 31, 1998........................... 51,726 $55,384 $2,029,238
                                                      ====== ======= ==========
</TABLE>




   The accompanying notes are an integral part of these financial statements

                                      F-48
<PAGE>

                               PRO MED CO., INC.

                            STATEMENTS OF CASH FLOWS

<TABLE>
<CAPTION>
                                                            For the Years
                                                                Ended
                                                            December 31,
                                                         --------------------
                                                           1998       1997
                                                         ---------  ---------
<S>                                                      <C>        <C>
Cash Flows From Operating Activities
Net income.............................................. $ 469,003  $ 334,605
Adjustments to reconcile net income to net cash used in
 operating activities:
  Depreciation and amortization.........................    98,584     90,026
  Gain (loss) on sale of fixed assets...................       --        (506)
  Amortization of discount on note payable..............       --      10,930
Changes in assets and liabilities:
  (Increase) decrease in accounts receivable............   160,384   (238,638)
  (Increase) decrease in inventory......................  (334,789)  (360,246)
  (Increase) decrease in prepaids and other assets......   (26,540)   108,061
  (Increase) decrease in income tax receivable..........       --      60,691
  Increase (decrease) in line of credit.................   186,677   (296,044)
  Increase (decrease) in accounts payable...............   117,492    480,024
  Increase (decrease) in sales tax payable..............    16,929     (6,659)
  Increase (decrease) in accrued expenses...............    33,859     18,127
  Increase (decrease) in income taxes payable...........    75,733        --
                                                         ---------  ---------
Net Cash Provided (Used) by Operating Activities........   797,332    200,371
                                                         ---------  ---------
Cash Flows From Investing Activities
Purchase of fixed assets................................   (38,946)  (159,518)
                                                         ---------  ---------
Net Cash Provided (Used) by Investing Activities........ $ (38,946) $(159,518)
                                                         ---------  ---------
Cash Flows From Financing Activities
(Increase) in related party receivables................. $(200,000) $     --
Proceeds from notes payable.............................       --     150,000
Principal payments on capital lease.....................    (8,412)    (9,287)
Principal payments on notes payable.....................  (549,974)  (181,566)
                                                         ---------  ---------
Net Cash Provided (Used) by Financing Activities........  (758,386)   (40,853)
                                                         ---------  ---------
Net Increase (decrease) In Cash.........................       --         --
Cash At Beginning of Year...............................       --         --
                                                         ---------  ---------
Cash At End of Year..................................... $     --   $     --
                                                         =========  =========
Cash Paid For:
  Interest expense...................................... $ 148,860  $ 149,546
  Income taxes.......................................... $ 174,454  $ 242,701
</TABLE>


   The accompanying notes are an integral part of these financial statements

                                      F-49
<PAGE>

                               PRO MED CO., INC.

                       NOTES TO THE FINANCIAL STATEMENTS

                           December 31, 1998 and 1997

NOTE 1--SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

 a. Organization

   Pro Med Co., Inc., (the Company) is a distributor of emergency medical
equipment primarily to ambulance services, fire departments and governmental
entities. The Company also distributes medical training products. The Company's
products are distributed to customers throughout the United States.

   Effective December 31, 1992, Laser Corporation (Laser) purchased 70 percent
of the Company's outstanding common stock for total consideration of
$2,000,000. Effective January 1, 1993, the purchase agreement was amended with
Laser Corporation acquiring an additional 10 percent of the Company's stock for
$100 resulting in Laser Corporation owning 80 percent of the Company.

   On January 1, 1995 the Company repurchased 48,274 shares of common stock and
extinguished the payable due to Laser Corporation with a $700,000 down payment
and two notes payable totaling $935,128. The remaining Laser owned shares
(31,726 shares) of common stock were purchased by officers and directors of the
Company. Any and all financial interests that Laser had in the Company have
been terminated as a result of this transaction. As of December 31, 1998, all
amounts due to Laser Corporation have been paid.

 b. Cash Equivalents

   The Company considers all highly liquid investments and deposits with a
maturity of three months or less when purchased to be cash equivalents.

 c. Marketable Securities

   The Company classifies its marketable debt and equity securities as "held to
maturity" if it has the positive intent and ability to hold the securities to
maturity. All other marketable debt and equity securities are classified as
"available for sale." Securities classified as "available for sale" are carried
in the financial statements at fair value. Realized gains and losses,
determined using the specific identification method, are included in earnings;
unrealized holding gains and losses are reported as a separate component of
stockholders' equity. Securities classified as held to maturity are carried at
amortized cost.

   For both categories of securities, declines in fair value below amortized
cost that are other than temporary are included in earnings.

   At December 31, 1998 and 1997, the market value approximated the cost of
marketable securities. Marketable securities at December 31, 1998 and 1997 were
$16,093 and $16,093, respectively, and have been included in prepaids and other
current assets.

 d. Accounting Method

   The Company's financial statements are prepared using the accrual method of
accounting. The Company has adopted a calendar year end.

   Sales revenue is recognized when the product is shipped to the customer and
expenses are recognized as incurred.


                                      F-50
<PAGE>

                               PRO MED CO., INC.

                 NOTES TO THE FINANCIAL STATEMENTS--(Continued)

                           December 31, 1998 and 1997

 e. Inventories

   Inventories consisting of emergency medical equipment and supplies are
stated at the lower of cost or market value using the average cost method.

 f. Property and Equipment

   Property and equipment are stated at cost. Depreciation is computed using
the straight-line method over the estimated useful life or lease term of the
related asset. Estimated useful lives are as follows:

<TABLE>
   <S>                                                               <C>
   Equipment........................................................    5 years
   Furniture and fixtures...........................................    5 years
   Building......................................................... 31.5 years
</TABLE>

 g. Income Taxes

   Deferred income taxes are provided for temporary differences in reporting
income for financial statement and tax purposes arising primarily from
differences between financial reporting and income tax reporting in the methods
of accounting for depreciation of property and equipment, accrued liabilities
and allowance for uncollectible receivables.

 h. Reclassification

   Certain amounts in the 1997 financial statements have been reclassified to
conform to the 1998 presentation.

 i. Accounts Receivable

   Accounts receivable are shown net of the allowance for doubtful accounts.
The allowance was $43,052 and $43,052 at December 31, 1998 and 1997,
respectively.

 j. Estimates

   The preparation of financial statements in conformity with generally
accepted accounting principles requires management to make estimates and
assumptions that affect the reported amounts of assets and liabilities and
disclosure of contingent assets and liabilities at the date of the financial
statements and the reported amounts of revenues and expenses during the
reporting period. Actual results could differ from those estimates.

 k. Advertising

   The Company follows the policy of charging the costs of advertising to
expense as incurred.


                                      F-51
<PAGE>

                               PRO MED CO., INC.

                 NOTES TO THE FINANCIAL STATEMENTS--(Continued)

                           December 31, 1998 and 1997

NOTE 2--FIXED ASSETS

   Fixed assets at December 31, 1998 and 1997 consisted of the following:

<TABLE>
<CAPTION>
                                                            1998        1997
                                                         ----------  ----------
   <S>                                                   <C>         <C>
   Equipment under capital leases....................... $      --   $   71,217
   Computer software....................................     90,352      85,734
   Equipment............................................    194,907     217,883
   Furniture and fixtures...............................     90,855      81,304
   Building.............................................    845,471     845,471
   Land.................................................    100,000     100,000
                                                         ----------  ----------
                                                          1,321,585   1,401,609
   Less accumulated depreciation and amortization.......   (247,570)   (267,956)
                                                         ----------  ----------
   Net Property and Equipment........................... $1,074,015  $1,133,653
                                                         ==========  ==========
</TABLE>

   Depreciation expense for the years ended December 31, 1998 and 1997 was
$98,584 and $90,026, respectively.

NOTE 3--LONG-TERM DEBT

   Long-term debt at December 31, 1998 and 1997 consists of the following;

<TABLE>
<CAPTION>
                                                           1998       1997
                                                         --------  ----------
   <S>                                                   <C>       <C>
   Note payable to a bank, secured by first deed of
    trust on building, payable in monthly installments
    of $5,679 including interest at 8.94% through
    November 2006......................................  $658,715  $  664,822
   Note payable to a bank, secured by a trust deed on
    the property, payable in monthly installments of
    $1,934 including interest at 9.25% through December
    2006...............................................   132,454     142,013
   Note payable to Laser Corporation, secured by pledge
    agreement and a personal guarantee by owners and
    officers of the Company, monthly principal and
    interest payments of $16,121, including interest of
    7.5% for 36 months, with a balloon payment due and
    payable on January 1, 1998.........................       --      372,034
   Note payable to Laser Corporation, secured by pledge
    agreement and a personal guarantee by owners and
    officers of the Company, with an imputed interest
    rate of 7.5% with total amount of principal and
    accrued interest of $162,274 due and payable on
    January 1, 1998....................................       --      162,274
                                                         --------  ----------
                                                          791,169   1,341,143
   Less current portion................................   (20,348)   (552,415)
                                                         --------  ----------
                                                         $770,821  $  788,728
                                                         ========  ==========
</TABLE>


                                      F-52
<PAGE>

                               PRO MED CO., INC.

                 NOTES TO THE FINANCIAL STATEMENTS--(Continued)

                           December 31, 1998 and 1997

   Future maturities of long-term debt are as follows:

<TABLE>
     <S>                                                                <C>
     1999.............................................................. $ 20,348
     2000..............................................................   22,120
     2001..............................................................   24,410
     2002..............................................................   26,745
     2003..............................................................   29,303
     Thereafter........................................................  668,243
                                                                        --------
       Total........................................................... $791,169
                                                                        ========
</TABLE>

NOTE 4--CAPITAL LEASE

   The Company leases certain equipment under long-term lease agreements. The
leases are classified as capital leases.

   The Company entered into a capital lease for office equipment as follows:

<TABLE>
<CAPTION>
                                                                 1998   1997
                                                                 ----- -------
   <S>                                                           <C>   <C>
   Capital lease payable in monthly principal and interest
    payments of $983, for sixty-two months beginning August 16,
    1993, interest rate of 12.25%, secured by office equipment.. $ --  $ 8,412
                                                                 ----- -------
                                                                         8,412
   Less current portion.........................................   --   (8,412)
                                                                 ----- -------
                                                                 $ --  $   --
                                                                 ===== =======
</TABLE>

NOTE 5--OPERATING LEASES

   The Company leases office space under a five year cancellable operating
lease. During the years ended December 31, 1998 and 1997, the Company
recognized annual rent expense of $44,423 and $38,133, respectively. The
following is a schedule of future minimum rental payments under the operating
lease at December 31, 1998.

<TABLE>
     <S>                                                                <C>
     1999.............................................................. $ 35,616
     2000..............................................................   35,616
     2001..............................................................   35,616
     2002..............................................................   35,616
     2003..............................................................   35,616
                                                                        --------
                                                                        $178,080
                                                                        ========
</TABLE>


                                      F-53
<PAGE>

                               PRO MED CO., INC.

                 NOTES TO THE FINANCIAL STATEMENTS--(Continued)

                           December 31, 1998 and 1997

NOTE 6--INCOME TAXES

   Income taxes for the years ended December 31, 1998 and 1997 consisted of the
following:

<TABLE>
<CAPTION>
                                                             1998       1997
                                                           ---------  ---------
   <S>                                                     <C>        <C>
   Taxes currently payable
     Federal.............................................. $ 228,129  $ 176,802
     State................................................    39,530     31,698
                                                           ---------  ---------
                                                             267,659    208,500
   Less prepayments.......................................  (191,378)  (208,500)
                                                           ---------  ---------
   Total taxes currently (receivable) payable............. $  76,281  $     --
                                                           =========  =========
</TABLE>

   Deferred income taxes have been calculated on the differences between the
tax basis of assets and the cost basis of those same assets represented in the
financial statements. The deferred tax assets relate to the Company's allowance
for bad debts.

   Income tax at the statutory rate is reconciled to the Company's actual
provision as follows:

<TABLE>
<CAPTION>
                                                                1998     1997
                                                              -------- --------
   <S>                                                        <C>      <C>
   Tax at federal statutory rate............................. $228,129 $176,802
   State income tax, net of federal tax benefit..............   39,530   31,698
   Deferred taxes payable--current...........................      --       --
   Deferred tax benefit--current.............................      --       --
                                                              -------- --------
     Income Tax Expense...................................... $267,659 $208,500
                                                              ======== ========
</TABLE>

   The deferred tax benefit of $17,100 relates to the allowance for doubtful
accounts of $43,052 and $43,052 in 1998 and 1997, respectively.

NOTE 7--LINE OF CREDIT

   The Company has obtained a line of credit from a bank which allows the
Company to draw up to $1,500,000 to cover operating expenses. The line of
credit is collateralized by the Company's accounts receivable and inventory,
and bears interest at 9.25%.

NOTE 8--NOTES RECEIVABLE--RELATED PARTIES

   The Company has a $100,000 note receivable from its President and Vice-
President, respectively. The notes bear interest at 9.5%, are unsecured and are
due in full on January 15, 2000. The total amount due from officers at December
31, 1998 is $203,167.

NOTE 9--YEAR 2000 ISSUE

   The Company is conducting a comprehensive review of its computer systems to
identify the systems that could be affected by the Year 2000 Issue, and is
developing an implementation plan to resolve the issue.


                                      F-54
<PAGE>

                               PRO MED CO., INC.

                 NOTES TO THE FINANCIAL STATEMENTS--(Continued)

                           December 31, 1998 and 1997

   The issue is whether computer systems will properly recognize date-sensitive
information when the year changes to 2000. Systems that do not properly
recognize such information could generate erroneous data or cause a system to
fail. The Company is heavily dependent on computer processing in the conduct of
its business activities.

 Estimated Cost of Remediation

   Because the Company has not completed its review of the computer systems,
management is unable to estimate the cost of making the systems year 2000
compliant.

                                      F-55
<PAGE>

                                                                         ANNEX A



                          AGREEMENT AND PLAN OF MERGER

                         dated as of September 21, 1999

                                     among

                              CHEMDEX CORPORATION,

                           POPCORN ACQUISITIONS CORP.

                                      and

                               PROMEDIX.COM, INC.
<PAGE>

                               TABLE OF CONTENTS
<TABLE>
<CAPTION>
                                                                           Page
                                                                           ----
 <C>             <S>                                                       <C>
 ARTICLE I THE MERGER....................................................    2
    Section 1.1  Effective Time of the Merger...........................     2
    Section 1.2  Closing................................................     2
    Section 1.3  Effects of the Merger..................................     2
    Section 1.4  Directors and Officers.................................     2
 ARTICLE II CONVERSION OF SECURITIES.....................................    3
    Section 2.1  Conversion of Capital Stock............................     3
    Section 2.2  Escrow Agreement.......................................     4
    Section 2.3  Dissenting Shares......................................     5
    Section 2.4  Exchange of Certificates...............................     5
    Section 2.5  Distributions with Respect to Unexchanged Shares.......     6
    Section 2.6  No Fractional Shares...................................     6
    Section 2.7  Tax and Accounting Consequences........................     6
 ARTICLE III REPRESENTATIONS AND WARRANTIES OF Promedix..................    7
    Section 3.1  Organization of Promedix...............................     7
    Section 3.2  Promedix Capital Structure.............................     7
    Section 3.3  Authority; No Conflict; Required Filings and Consents..     8
    Section 3.4  Financial Statements; Absence of Undisclosed
                 Liabilities............................................     9
    Section 3.5  Tax Matters............................................    10
    Section 3.6  Absence of Certain Changes or Events...................    11
    Section 3.7  Title and Related Matters..............................    12
    Section 3.8  Proprietary Rights.....................................    13
    Section 3.9  Employee Benefit Plans.................................    15
    Section 3.10 Bank Accounts..........................................    16
    Section 3.11 Contracts..............................................    16
    Section 3.12 Compliance With Law....................................    17
    Section 3.13 Labor Difficulties; No Discrimination..................    18
    Section 3.14 Insider Transactions...................................    18
    Section 3.15 Employees, Independent Contractors and Consultants.....    18
    Section 3.16 Insurance..............................................    19
    Section 3.17 Litigation.............................................    19
    Section 3.18 Governmental Authorizations and Regulations............    19
    Section 3.19 Subsidiaries...........................................    19
    Section 3.20 Compliance with Environmental Requirements.............    19
    Section 3.21 Trade Regulation.......................................    20
    Section 3.22 Year 2000 Compliance...................................    20
    Section 3.23 Corporate Documents....................................    20
    Section 3.24 No Brokers.............................................    20
    Section 3.25 Promedix Action........................................    20
    Section 3.26 Offers.................................................    20
    Section 3.27 Disclosure.............................................    20
    Section 3.28 Registration Statement; Proxy Statement/Prospectus.....    21
 ARTICLE IV REPRESENTATIONS AND WARRANTIES OF CHEMDEX AND SUB............   21
    Section 4.1  Organization of Chemdex and Sub........................    21
    Section 4.2  Capitalization.........................................    21
    Section 4.3  Authority; No Conflict; Required Filings and Consents..    22
</TABLE>

                                       i
<PAGE>

<TABLE>
<CAPTION>
                                                                          Page
                                                                          ----
 <C>             <S>                                                      <C>
    Section 4.4  Commission Filings; Financial Statements...............   23
    Section 4.5  Compliance with Laws...................................   23
    Section 4.6  Interim Operations of Sub..............................   24
    Section 4.7  Disclosure.............................................   24
    Section 4.8  Registration Statement; Proxy Statement/Prospectus.....   24
    Section 4.9  No Broker..............................................   24
    Section 4.10 Chemdex Action.........................................   24
    Section 4.11 Offers.................................................   24
    Section 4.12 Litigation.............................................   24
    Section 4.13 Absence of Certain change or Events....................   25
 ARTICLE V PRECLOSING COVENANTS OF PROMEDIX..............................  25
    Section 5.1  Advice of Changes......................................   25
    Section 5.2  Operation of Business..................................   25
    Section 5.3  Access to Information..................................   27
    Section 5.4  Satisfaction of Conditions Precedent...................   27
    Section 5.5  Other Negotiations.....................................   27
 ARTICLE VI PRECLOSING AND OTHER COVENANTS OF CHEMDEX AND SUB............  28
    Section 6.1  Advice of Changes......................................   28
    Section 6.2  Reservation of Chemdex Common Stock....................   28
    Section 6.3  Satisfaction of Conditions Precedent...................   28
    Section 6.4  Nasdaq National Market Listing.........................   28
    Section 6.5  Stock Options..........................................   28
    Section 6.6  Certain Employee Benefit Matters.......................   29
    Section 6.7  Contingent Financing...................................   30
    Section 6.8  D&O Indemnification....................................   30
    Section 6.9  Salt Lake City Presence................................   30
    Section 6.10 Operation of Business..................................   30
    Section 6.11 Other Negotiations.....................................   30
 ARTICLE VII--PRECLOSING COVENANTS OF PROMEDIX AND CHEMDEX AND OTHER
  AGREEMENTS.............................................................  31
    Section 7.1  Proxy Statement/Prospectus.............................   31
    Section 7.2  Stockholder Meetings...................................   32
    Section 7.3  Confidentiality........................................   33
    Section 7.3  No Public Announcement.................................   33
    Section 7.4  Regulatory Filings; Consents; Reasonable Efforts.......   33
    Section 7.5  Further Assurances.....................................   33
    Section 7.6  Escrow Agreement.......................................   33
    Section 7.7  FIRPTA.................................................   33
    Section 7.8  Other Filings..........................................   34
    Section 7.10 Tax Matters............................................   34
 ARTICLE VIII CONDITIONS TO MERGER.......................................  34
    Section 8.1  Conditions to Each Party's Obligation to Effect the
                 Merger.................................................   34
    Section 8.2  Additional Conditions to Obligations of Chemdex and
                 Sub....................................................   35
    Section 8.3  Additional Conditions to Obligations of Promedix.......   36
 ARTICLE IX TERMINATION AND AMENDMENT....................................  36
    Section 9.1  Termination............................................   36
</TABLE>

                                       ii
<PAGE>

<TABLE>
<CAPTION>
                                                                            Page
                                                                            ----
 <C>              <S>                                                       <C>
    Section 9.2   Effect of Termination...................................   37
    Section 9.3   Fees and Expenses.......................................   37
 ARTICLE X ESCROW AND INDEMNIFICATION......................................  38
    Section 10.1  Indemnification.........................................   38
    Section 10.2  Escrow Fund.............................................   38
    Section 10.3  Escrow Periods..........................................   38
    Section 10.4  Claims Upon Escrow Fund.................................   38
    Section 10.5  Valuation...............................................   39
    Section 10.6  Objections to Claims....................................   39
    Section 10.7  Resolution of Conflicts.................................   39
    Section 10.8  Stockholders' Agents....................................   40
    Section 10.9  Actions of the Stockholders' Agents.....................   40
    Section 10.10 Claims..................................................   40
 ARTICLE XI MISCELLANEOUS..................................................  41
    Section 11.1  Survival of Representations and Covenants...............   41
    Section 11.2  Notices.................................................   41
    Section 11.3  Interpretation..........................................   42
    Section 11.4  Counterparts............................................   42
    Section 11.5  Entire Agreement; No Third Party Beneficiaries..........   42
    Section 11.6  Governing Law; Jurisdiction.............................   42
    Section 11.7  Assignment..............................................   42
    Section 11.8  Amendment...............................................   42
    Section 11.9  Extension; Waiver.......................................   42
    Section 11.10 Specific Performance....................................   43
</TABLE>

<TABLE>
<CAPTION>
 EXHIBITS
 --------
 <C>       <C> <S>                                                           <C>
 EXHIBIT A  -- VOTING AGREEMENT............................................   45
 EXHIBIT B  -- EMPLOYMENT AGREEMENT........................................   51
 EXHIBIT C  -- AFFILIATES AGREEMENT........................................   67
 EXHIBIT D  -- STOCK RESTRICTION AGREEMENT.................................   73
 EXHIBIT E  -- ESCROW AGREEMENT............................................   82
 EXHIBIT F  -- SUBJECT MATTER OF OPINION OF COUNSEL TO PROMEDIX............   94
 EXHIBIT G  -- LOAN AGREEMENT..............................................   95
 EXHIBIT H  -- FULFILLMENT BUSINESS TERM SHEET.............................  128
 EXHIBIT I  -- SUBJECT MATTER OF OPINION OF COUNSEL TO CHEMDEX.............  129
</TABLE>

                                      iii
<PAGE>

                          AGREEMENT AND PLAN OF MERGER

   THIS AGREEMENT AND PLAN OF MERGER, dated as of September 21, 1999 (this
"Agreement"), is entered into by and among Chemdex Corporation, a Delaware
corporation ("Chemdex"), Popcorn Acquisitions Corp., a Delaware corporation and
a wholly-owned subsidiary of Chemdex ("Sub"), and Promedix.com, Inc., a
Delaware corporation ("Promedix").

                                    RECITALS

   A. The Boards of Directors of Chemdex, Sub and Promedix deem it advisable
and in the best interests of each corporation and their respective stockholders
that Chemdex and Promedix combine in order to advance the long-term business
interests of Chemdex and Promedix;

   B. The combination of Chemdex and Promedix shall be effected by the terms of
this Agreement through a transaction in which Sub will merge with and into
Promedix, Promedix will become a wholly-owned subsidiary of Chemdex and the
stockholders of Promedix will become stockholders of Chemdex (the "Merger");

   C. For Federal income tax purposes, it is intended that the Merger shall
qualify as a reorganization within the meaning of Section 368(a) of the
Internal Revenue Code of 1986, as amended (the "Code");

   D. For accounting purposes, it is intended that the Merger shall be
accounted for as a purchase transaction;

   E. As a condition and inducement to Chemdex's willingness to enter into this
Agreement, certain Promedix common and preferred stockholders have,
concurrently with the execution of this Agreement, executed and delivered
Voting Agreements in the form attached hereto as Exhibit A (the "Voting
Agreements"), pursuant to which such stockholders have, among other things,
agreed to vote their shares of Promedix capital stock in favor of the Merger
and to grant Chemdex irrevocable proxies to vote such shares;

   F. As a further condition and inducement to Chemdex's willingness to enter
into this Agreement, certain employees of Promedix who are also Promedix equity
holders will have concurrently with the execution of this Agreement, executed
and delivered Employment and Noncompetition Agreements in the form attached
hereto as Exhibit B (the "Employment Agreements"), which agreements shall only
become effective at the Effective Time (as defined in Section 1.1 below);

   G. As a further condition and inducement to Chemdex's and Promedix's
willingness to enter into this Agreement, certain stockholders of Promedix have
executed and delivered an Affiliates Agreement in the form attached hereto as
Exhibit C (the "Affiliates Agreement").

   H. As a further condition and inducement to Chemdex's willingness to enter
into this Agreement, Skip Klintworth and Brad Bond have, concurrently with the
execution of this Agreement, executed and delivered their Stock Restriction
Agreements in the form attached hereto as Exhibit D (the "Stock Restriction
Agreements"), which agreements shall only become effective at the Effective
Time.

                                      A-1
<PAGE>

   NOW, THEREFORE, in consideration of the foregoing and the respective
representations, warranties, covenants and agreements set forth below, the
parties agree as follows:

                                   ARTICLE I

                                   THE MERGER

   Section 1.1 Effective Time of the Merger.

     (a) Subject to the provisions of this Agreement, a certificate of merger
  (the "Certificate of Merger") in such mutually acceptable form as is
  required by the relevant provisions of the Delaware General Corporation Law
  ("Delaware Law") shall be duly executed and delivered by the parties hereto
  and thereafter delivered to the Secretary of State of the State of Delaware
  for filing on the Closing Date (as defined in Section 1.2).

     (b) The Merger shall become effective upon the due and valid filing of
  the Certificate of Merger with the Secretary of State of the State of
  Delaware or at such time thereafter as is provided in the Certificate of
  Merger (the "Effective Time").

   Section 1.2 Closing. The closing of the Merger (the "Closing") will take
place at 10:00 a.m., California time, on a date (the "Closing Date") to be
specified by Chemdex and Promedix, which shall be no later than the second
business day after satisfaction or waiver of the latest to occur of the
conditions set forth in Article VIII, at the offices of Venture Law Group, A
Professional Corporation, 2775 Sand Hill Road, Menlo Park, California unless
another date, time or place is agreed to in writing by Chemdex and Promedix.

   Section 1.3 Effects of the Merger.

     (a) At the Effective Time (i) the separate existence of Sub shall cease
  and Sub shall be merged with and into Promedix (Sub and Promedix are
  sometimes referred to herein as the "Constituent Corporations" and Promedix
  following consummation of the Merger is sometimes referred to herein as the
  "Surviving Corporation"), (ii) the Certificate of Incorporation of Sub
  shall be the Certificate of Incorporation of the Surviving Corporation and
  (iii) the Bylaws of Sub as in effect immediately prior to the Effective
  Time shall become the Bylaws of the Surviving Corporation.

     (b) At the Effective Time, the effect of the Merger shall be as provided
  in the applicable provisions of Delaware Law. Without limiting the
  generality of the foregoing, at and after the Effective Time, the Surviving
  Corporation shall possess all the rights, privileges, powers and
  franchises, and be subject to all the restrictions, disabilities and duties
  of each of the Constituent Corporations.

   Section 1.4 Directors and Officers. The directors of Sub immediately prior
to the Effective Time shall become the directors of the Surviving Corporation,
each to hold office in accordance with the Certificate of Incorporation and
Bylaws of the Surviving Corporation, and the officers of Sub immediately prior
to the Effective Time shall become the officers of the Surviving Corporation,
in each case until their respective successors are duly elected or appointed
and qualified.

                                      A-2
<PAGE>

                                   ARTICLE II

                            CONVERSION OF SECURITIES

   Section 2.1 Conversion of Capital Stock. At the Effective Time, by virtue of
the Merger and without any action on the part of the holder of any shares of
Series A, Series B-1, or Series B-2 Preferred Stock of Promedix, each $0.0001
par value (collectively, the "Promedix Preferred Stock"), or shares of Common
Stock of Promedix, $0.0001 par value ("Promedix Common Stock"), or capital
stock of Sub:

     (a) Capital Stock of Sub. Each issued and outstanding share of the
  capital stock of Sub shall be converted into and become one fully paid and
  nonassessable share of Common Stock, $0.0001 par value, of the Surviving
  Corporation.

     (b) Cancellation of Chemdex-Owned and Promedix-Owned Stock. Any shares
  of Promedix Common Stock or Promedix Preferred Stock that are owned by
  Chemdex, Sub, Promedix or any other direct or indirect wholly-owned
  Subsidiary of Chemdex or Promedix shall be canceled and retired and shall
  cease to exist and no stock of Chemdex or other consideration shall be
  delivered in exchange. As used in this Agreement, the word "Subsidiary"
  means, with respect to any other party, any corporation or other
  organization, whether incorporated or unincorporated, of which (i) such
  party or any other Subsidiary of such party is a general partner (excluding
  partnerships, the general partnership interests of which held by such party
  or any Subsidiary of such party do not have a majority of the voting
  interest in such partnership) or (ii) at least a majority of the securities
  or other interests having by their terms ordinary voting power to elect a
  majority of the Board of Directors or others performing similar functions
  with respect to such corporation or other organization or a majority of the
  profit interests in such other organization is directly or indirectly owned
  or controlled by such party or by any one or more of its Subsidiaries, or
  by such party and one or more of its Subsidiaries.

     (c) Exchange Ratio.

       (i) Each issued and outstanding share of Promedix Common Stock and
    Promedix Preferred Stock (other than shares to be canceled in
    accordance with Section 2.1(b) and any Dissenting Shares as defined in
    and to the extent provided in Section 2.3) shall, by virtue of the
    Merger and without any action on the part of the holder thereof, be
    converted into the right to receive a fraction of a fully paid and
    nonassessable share of Chemdex Common Stock (as defined in Section 4.2)
    equal to the Exchange Ratio, as defined in and determined in accordance
    with the provisions of subparagraph (ii) below.

       (ii) For purposes of this Agreement:

         (A) the "Total Consideration Shares" shall be equal to 12,057,366
      shares of Chemdex Common Stock.

         (B) The "Exchange Ratio" shall be equal to the quotient obtained
      by dividing (1) the number of the Total Consideration Shares by (2)
      the number of shares of Promedix Common Stock outstanding or subject
      to issuance upon exercise of Promedix Options (as defined in Section
      2.1(d) below) and Promedix Warrants (as defined in Section 2.1(d)
      below) and upon conversion of all shares of Promedix Preferred Stock
      issued and outstanding, in each case immediately prior to the
      Effective Time.

       (iii) In no event will the total number of shares of Chemdex Common
    Stock issuable by Chemdex pursuant to the Merger (including shares of
    Chemdex Common Stock issuable upon exercise of Promedix Options or
    Promedix Warrants assumed by Chemdex in the Merger) exceed the Total
    Consideration Shares. The allocation of the Total Consideration Shares
    among each holder of Promedix capital stock, warrants, and options
    based upon the capitalization of Promedix as of the

                                      A-3
<PAGE>

    date of this Agreement is set forth in the Promedix Disclosure
    Schedule. An updated version of such Schedule reflecting the
    capitalization of Promedix on the Closing Date shall be delivered by
    Promedix to Chemdex on the Closing Date.

       (iv) If, on or after the date of this Agreement and prior to the
    Effective Time, the outstanding shares of Chemdex Common Stock or
    Promedix capital stock shall have been changed into a different number
    of shares or a different class by reason of any reclassification,
    split-up, stock dividend (including any dividend or distribution of
    securities convertible into Chemdex Common Stock) or stock combination,
    then the Exchange Ratio shall be correspondingly adjusted. The Exchange
    Ratio shall not change as a result of fluctuations in the market price
    of Chemdex Common Stock between the date of this Agreement and the
    Effective Time.

       (v) All such shares of Promedix Common Stock and Promedix Preferred
    Stock, when so converted, shall no longer be outstanding and shall
    automatically be canceled and retired and shall cease to exist, and
    each holder of a certificate representing any such shares shall cease
    to have any rights with respect thereto, except the right to receive
    the shares of Chemdex Common Stock and any cash in lieu of fractional
    shares of Chemdex Common Stock to be issued or paid in consideration
    therefor upon the surrender of such certificate in accordance with
    Section 2.4, without interest.

     (d) Promedix Stock Options and Warrants. At the Effective Time, all then
  outstanding options, whether vested or unvested ("Promedix Options"), to
  purchase Promedix Common Stock issued under Promedix's 1998 Stock Option
  Plan (the "Promedix Option Plan"), and all outstanding warrants to purchase
  Promedix capital stock ("Promedix Warrants") that by their terms survive
  the closing, will be assumed by Chemdex in accordance with Section 6.5. All
  of the Promedix Options and Promedix Warrants issued and outstanding as of
  the date of this Agreement are listed on Schedule 2.1(d) attached hereto.
  An updated Schedule 2.1(d) of Promedix Options and Promedix Warrants shall
  be delivered by Promedix to Chemdex on the Closing Date.

     (e) Restricted Shares. Any shares of Promedix Common Stock which are
  subject to repurchase by Promedix in the event the holder thereof ceases to
  be employed by Promedix ("Promedix Restricted Shares") shall be converted
  into Chemdex Common Stock on the same basis as provided in subsection (c)
  above and shall be registered in such holder's name, but shall be held by
  the Surviving Corporation or Chemdex pursuant to the applicable restricted
  stock repurchase agreements with the same repurchase provisions applicable
  to such shares prior to the conversion. Holders of the Promedix Restricted
  Shares are identified on Schedule 2.1(e) of the Promedix Disclosure
  Schedule.

   Section 2.2 Escrow Agreement. At the Effective Time or such later time as
determined in accordance with Section 2.3(b), Chemdex will, on behalf of the
holders of Promedix Common Stock and Promedix Preferred Stock, deposit in
escrow certificates representing the percentage of the Total Consideration
Shares set forth below allocable to Promedix Common Stock and Promedix
Preferred Stock in the Merger. Such shares shall be held in escrow on behalf of
the persons who are the holders of Promedix Common Stock or Promedix Preferred
Stock in the Merger immediately prior to the Effective Time (the "Former
Promedix Stockholders"), in accordance with the portion of Total Consideration
Shares allocable to each such Former Promedix Stockholder in the manner
contemplated by Section 2.1 ("Pro Rata Portion"). If the Closing shall occur
prior to January 22, 2000, then ninety percent (90%) of such shares
(collectively, the "Locked Up Shares") shall be held in escrow on behalf of the
former Promedix Stockholders until January 22, 2000, after which the
certificates representing the Locked Up Shares will be distributed to the
Former Promedix Stockholders. The Locked Up Shares shall not be subject to
Article X of this Agreement. Ten percent (10%) of such shares (collectively,
the "Escrow Shares") shall be held in escrow and applied pursuant to the
provisions of an escrow agreement (the "Escrow Agreement") to be executed
pursuant to Section 7.6. All calculations to determine the number of Locked Up
Shares and Escrow Shares to be delivered by each stockholder of Promedix into
escrow as aforesaid shall be rounded down to the nearest whole share.

                                      A-4
<PAGE>

   Section 2.3 Dissenting Shares.

     (a) Notwithstanding any provision of this Agreement to the contrary, any
  shares of Promedix Common Stock or Promedix Preferred Stock held by a
  holder who has exercised such holder's appraisal rights in accordance with
  Section 262 of Delaware Law, and who, as of the Effective Time, has not
  effectively withdrawn or lost such appraisal rights ("Dissenting Shares"),
  shall not be converted into or represent a right to receive Chemdex Common
  Stock pursuant to Section 2.1, but the holder of the Dissenting Shares
  shall only be entitled to such rights as are granted by Delaware Law.

     (b) Notwithstanding the provisions of Section 2.3(a), if any holder of
  shares of Promedix Common Stock or Promedix Preferred Stock who demands his
  appraisal rights with respect to such shares under Section 2.1 shall
  effectively withdraw or lose (through failure to perfect or otherwise) his
  rights to receive payment for such shares under Delaware Law, then, as of
  the later of the Effective Time or the occurrence of such event, such
  holder's shares shall automatically be converted into and represent only
  the right to receive Chemdex Common Stock and payment for fractional shares
  as provided in Section 2.1(c), without interest, upon surrender of the
  certificate or certificates representing such shares; provided that if such
  holder effectively withdraws or loses his right to receive payment for such
  shares after the Effective Time, then, at such time Chemdex will deposit in
  the escrow created pursuant to the Escrow Agreement additional certificates
  representing such holder's Pro Rata Portion of the Escrow Shares.

     (c) Promedix shall give Chemdex (i) prompt notice of any written demands
  for payment with respect to any shares of capital stock of Promedix
  pursuant to the appraisal rights under Delaware Law, withdrawals of such
  demands, and any other instruments served pursuant to Delaware Law and
  received by the Promedix and (ii) the opportunity to participate at its own
  expense in all negotiations and proceedings with respect to demands for
  appraisal rights under Delaware Law. Promedix shall not, except with the
  prior written consent of Chemdex, voluntarily make any payment with respect
  to any demands for appraisal rights with respect to Promedix Common Stock
  or Promedix Preferred Stock or offer to settle or compromise any such
  demands.

   Section 2.4 Exchange of Certificates.

     (a) From and after the Effective Time, each holder of an outstanding
  certificate or certificates ("Certificates") which represented shares of
  Promedix Common Stock or Promedix Preferred Stock immediately prior to the
  Effective Time shall have the right to surrender each Certificate to
  Chemdex (or at Chemdex's option, an exchange agent to be appointed by
  Chemdex), and subject to and in accordance with Section 2.2 above and the
  Escrow Agreement, receive in exchange for all Certificates held by such
  holder a certificate representing the number of whole shares of Chemdex
  Common Stock (other than the Escrow Shares) into which the Promedix Common
  Stock or Promedix Preferred Stock evidenced by the Certificates so
  surrendered shall have been converted pursuant to the provisions of Article
  II of this Agreement. The surrender of Certificates shall be accompanied by
  duly completed and executed Letters of Transmittal in such form as may be
  reasonably specified by Chemdex. Until surrendered, each outstanding
  Certificate which prior to the Effective Time represented shares of
  Promedix Common Stock or Promedix Preferred Stock shall be deemed for all
  corporate purposes to evidence ownership of the number of whole shares of
  Chemdex Common Stock into which the shares of Promedix Common Stock have
  been converted but shall, subject to applicable appraisal rights under
  Delaware Law, have no other rights (except as provided in Section 2.6 with
  respect to fractional shares, if any). Subject to applicable appraisal
  rights under Delaware Law, from and after the Effective Time, the holders
  of shares of Promedix Common Stock and Promedix Preferred Stock shall cease
  to have any rights in respect of such shares and their rights shall be
  solely in respect of the Chemdex Common Stock into which such shares of
  Promedix Common Stock or Promedix Preferred Stock have been converted
  (except as provided in Section 2.6 with respect to fractional shares, if
  any). From and after the Effective Time, there shall be no further
  registration of transfers on the records of Promedix of shares of Promedix
  Common Stock and Promedix Preferred Stock outstanding immediately prior to
  the Effective Time.

                                      A-5
<PAGE>

     (b) If any shares of Chemdex Common Stock are to be issued in the name
  of a person other than the person in whose name the Certificate(s)
  surrendered in exchange therefor is registered, it shall be a condition to
  the issuance of such shares that (i) the Certificate(s) so surrendered
  shall be transferable, and shall be properly assigned, endorsed or
  accompanied by appropriate stock powers, (ii) such transfer shall otherwise
  be proper and (iii) the person requesting such transfer shall pay Chemdex,
  or its exchange agent, any transfer or other taxes payable by reason of the
  foregoing or establish to the satisfaction of Chemdex that such taxes have
  been paid or are not required to be paid. Notwithstanding the foregoing,
  neither Chemdex nor Promedix shall be liable to a holder of shares of
  Promedix Common Stock or Promedix Preferred Stock for shares of Chemdex
  Common Stock issuable to such holder pursuant to the provisions of Article
  II of this Agreement that are delivered to a public official pursuant to
  applicable abandoned property, escheat or similar laws.

     (c) In the event any Certificate shall have been lost, stolen or
  destroyed, upon the making of an affidavit of that fact by the person
  claiming such Certificate to be lost, stolen or destroyed, Chemdex shall
  issue in exchange for such lost, stolen or destroyed Certificate the shares
  of Chemdex Common Stock issuable in exchange therefor pursuant to the
  provisions of Article II of the Agreement. The Board of Directors of
  Chemdex may in its discretion and as a condition precedent to the issuance
  thereof, require the owner of such lost, stolen or destroyed Certificate to
  provide to Chemdex an indemnity agreement or bond against any claim that
  may be made against Chemdex with respect to the Certificate alleged to have
  been lost, stolen or destroyed.

   Section 2.5 Distributions with Respect to Unexchanged Shares. No dividends
or other distributions declared or made after the Effective Time with respect
to Chemdex Common Stock with a record date after the Effective Time shall be
paid to the holder of any unsurrendered Certificate with respect to the shares
of Chemdex Common Stock represented thereby and no cash payment in lieu of
fractional shares shall be paid to any such holder pursuant to Section 2.6
below until the holder of record of such Certificate shall surrender such
Certificate. Subject to the effect of applicable laws, following surrender of
any such Certificate, there shall be paid to the record holder of the
certificates representing whole shares of Chemdex Common Stock issued in
exchange therefor, without interest, (i) at the time of such surrender, the
amount of any cash payable in lieu of a fractional share of Chemdex Common
Stock to which such holder is entitled pursuant to Section 2.6 below and the
amount of any dividends or other distributions with a record date after the
Effective Time previously paid with respect to such whole shares of Chemdex
Common Stock, and (ii) at the appropriate payment date, the amount of dividends
or other distributions with a record date after the Effective Time but prior to
surrender and a payment date subsequent to surrender payable with respect to
such whole shares of Chemdex Common Stock.

   Section 2.6 No Fractional Shares. No certificate or scrip representing
fractional shares of Chemdex Common Stock shall be issued upon the surrender
for exchange of Certificates, and such fractional share interests will not
entitle the owner thereof to vote or to any rights of a stockholder of Chemdex.
Notwithstanding any other provision of this Agreement, each holder of shares of
Promedix Common Stock or Promedix Preferred Stock exchanged pursuant to the
Merger who would otherwise have been entitled to receive a fraction of a share
of Chemdex Common Stock (after taking into account all Certificates delivered
by such holder) shall receive, in lieu thereof, cash (without interest) in an
amount equal to such fractional part of a share of Chemdex Common Stock
multiplied by the average closing price of Chemdex's Common Stock on the Nasdaq
Stock Market for the ten (10) trading day period ending two (2) trading days
prior to the Closing Date (the "Average Stock Price").

   Section 2.7 Tax and Accounting Consequences.

     (a) It is intended by the parties hereto that the Merger shall
  constitute a "reorganization" within the meaning of Section 368 of the
  Code. The parties hereto adopt this Agreement as a "plan of reorganization"
  within the meaning of Sections 1.368-2(g) and 1.368-3(a) of the United
  States Income Tax Regulations.

                                      A-6
<PAGE>

     (b) It is intended by the parties hereto that the Merger shall qualify
  for financial accounting treatment as purchase accounting.

                                  ARTICLE III

                   REPRESENTATIONS AND WARRANTIES OF PROMEDIX

   Promedix represents and warrants to Chemdex and Sub that the statements
contained in this Article III are true and correct, except as expressly set
forth in the disclosure schedule delivered by Promedix to Chemdex on or before
the date of this Agreement (the "Promedix Disclosure Schedule"). The Promedix
Disclosure Schedule shall be arranged in paragraphs corresponding to the
numbered and lettered paragraphs contained in this Article III.

   Section 3.1 Organization of Promedix. Promedix is a corporation duly
organized, validly existing and in good standing under the laws of the State of
Delaware, has all requisite corporate power to own, lease and operate its
property and to carry on its business as now being conducted, and is duly
qualified or licensed to do business and is in good standing as a foreign
corporation in each jurisdiction in which the nature of its business or
ownership or leasing of properties makes such qualification or licensing
necessary and where the failure to be so qualified or licensed would result in
a material adverse effect on the business, assets (including intangible
assets), condition (financial or otherwise), or results of operations (a
"Material Adverse Effect") of Promedix. The Promedix Disclosure Schedule
contains a true and complete listing of the locations of all sales offices,
development facilities, and any other offices or facilities of Promedix and a
true and complete list of all states in which Promedix maintains any employees.
The Promedix Disclosure Schedule contains a true and complete list of all
states in which Promedix is duly qualified or licensed to transact business as
a foreign corporation.

   Section 3.2 Promedix Capital Structure.

     (a) The authorized capital stock of Promedix consists of 25,000,000
  shares of Promedix Common Stock and 5,709,443 shares of Preferred Stock, of
  which 4,030,089 shares are designated as Series A Preferred Stock, 333,334
  shares are designated as Series B-1 Preferred Stock, and 346,020 shares are
  designated as Series B-2 Preferred Stock, and 1,000,000 shares are
  designated as Series C Preferred Stock. As of the date of this Agreement,
  there are (i) 3,546,250 shares of Promedix Common Stock issued and
  outstanding, all of which are validly issued, fully paid and nonassessable
  and 100,000 shares of which are subject to repurchase rights pursuant to
  agreements or arrangements between the holder thereof and Promedix, (ii)
  4,030,089 shares of Series A Preferred Stock issued and outstanding, all of
  which are validly issued, fully paid and nonassessable, and each share of
  which is convertible into one share of Promedix Common Stock, (iii) 333,334
  shares of Series B-1 Preferred Stock issuable upon exercise of outstanding
  warrants, (iv) 346,020 shares of Series B-2 Preferred Stock issuable upon
  conversion of outstanding convertible notes (the "Convertible Debt"), (v)
  no shares of Series C Preferred Stock are issued or outstanding, (vi)
  Promedix Options to purchase up to 1,197,761 shares of Promedix Common
  Stock, (vii) 5,709,443 shares of Promedix Common Stock reserved for future
  issuance upon conversion of the Promedix Preferred Stock, and (viii)
  572,239 shares of Promedix Common Stock reserved for issuance upon exercise
  of options available to be granted in the future under the Promedix Option
  Plan. The issued and outstanding shares of Promedix Common Stock and of
  Promedix Preferred Stock are held of record by the stockholders of Promedix
  as set forth and identified on Schedule 3.2(a) of the Promedix Disclosure
  Schedule. The issued and outstanding Promedix Options are held of record by
  the option holders identified on, in the amounts and subject to the vesting
  schedules set forth on, Schedule 3.2(a) of the Promedix Disclosure
  Schedule. The issued and outstanding Promedix Warrants are held of record
  by the warrantholders set forth in Schedule 3.2(a) of the Promedix
  Disclosure Schedule. All shares of Promedix Common Stock subject to
  issuance upon the exercise of Promedix Options and Promedix Warrants, upon
  issuance on the terms and conditions (including payment) specified in the
  instrument pursuant to which they are issuable, will be duly authorized,
  validly issued, fully paid and nonassessable. All outstanding

                                      A-7
<PAGE>

  shares of Promedix Common Stock, Promedix Preferred Stock and outstanding
  Promedix Options and Promedix Warrants (collectively "Promedix Securities")
  were issued in compliance with applicable federal and state securities
  laws. Except as set forth in the Promedix Disclosure Schedule, there are no
  obligations, contingent or otherwise, of Promedix to repurchase, redeem or
  otherwise acquire any shares of Promedix Common Stock or Promedix Preferred
  Stock or make any investment (in the form of a loan, capital contribution
  or otherwise) in any other entity. An updated Schedule 3.2(a) reflecting
  changes permitted by this Agreement in the capitalization of Promedix
  between the date hereof and the Effective Time shall be delivered by
  Promedix to Chemdex on the Closing Date.

     (b) Except as set forth in this Section 3.2, there are no equity
  securities of any class or series of Promedix, or any security exchangeable
  into or exercisable for such equity securities, issued, reserved for
  issuance or outstanding. Except as set forth in this Section 3.2, there are
  no options, warrants, equity securities, calls, rights, commitments or
  agreements of any character to which Promedix is a party or by which it is
  bound obligating Promedix to issue, deliver or sell, or cause to be issued,
  delivered or sold, additional shares of capital stock of Promedix or
  obligating Promedix to grant, extend, accelerate the vesting of or enter
  into any such option, warrant, equity security, call, right, commitment or
  agreement. Except in the case of Tenet Healthcare Corporation and other
  strategic investors approved in writing in advance by Chemdex ("Strategic
  Investors"), Promedix is not in active discussion, formal or informal, with
  any person or entity regarding the issuance of any form of additional
  Promedix equity that has not been issued or committed to prior to the date
  of this Agreement. Except as provided in this Agreement and the other
  Transaction Documents (as defined in Section 3.3(a)) or any transaction
  contemplated hereby or thereby, there are no voting trusts, proxies or
  other agreements or understandings with respect to the voting of the shares
  of capital stock of Promedix.

     (c) All Promedix Options have been issued in accordance with the terms
  of the Promedix Option Plan and pursuant to the standard forms of option
  agreement previously provided to Chemdex or its representatives. No
  Promedix Option will by its terms require an adjustment in connection with
  the Merger. Except as otherwise contemplated by Section 6.5(b), neither the
  consummation of transactions contemplated by this Agreement or the other
  Transaction Documents, nor any action taken or to be taken by Promedix in
  connection with such transactions will result in (i) any acceleration of
  vesting in favor of any optionee under any Promedix Option; (ii) any
  additional benefits for any optionee under any Promedix Option; or (iii)
  the inability of Chemdex after the Effective Time to exercise any right or
  benefit held by Promedix prior to the Effective Time with respect to any
  Promedix Option assumed by Chemdex, including, without limitation, the
  right to repurchase an optionee's unvested shares on termination of such
  optionee's employment. Except as otherwise contemplated by Section 6.5(b),
  the assumption by Chemdex of Promedix Options in accordance with Section
  6.5 hereunder will not (i) give the optionees additional benefits which
  they did not have under their options prior to such assumption (after
  taking into account the existing provisions of the options, such as their
  respective exercise prices and vesting schedules) or (ii) constitute a
  breach of the Promedix Plan or any agreement entered into pursuant to such
  plan.

   Section 3.3 Authority; No Conflict; Required Filings and Consents.

     (a) Promedix has all requisite corporate power and authority to enter
  into this Agreement and all Transaction Documents to which it is or will
  become a party and to consummate the transactions contemplated by this
  Agreement and such Transaction Documents. The execution and delivery of
  this Agreement and such Transaction Documents and the consummation of the
  transactions contemplated by this Agreement and such Transaction Documents
  have been duly authorized by all necessary corporate action on the part of
  Promedix, subject only to the approval of the Merger by Promedix's
  stockholders under the provisions of Delaware Law and Promedix's
  Certificate of Incorporation. This Agreement has been and such Transaction
  Documents have been or, to the extent not executed by Promedix as of the
  date hereof, will be duly executed and delivered by Promedix. This
  Agreement and each of the Transaction Documents to which Promedix is a
  party constitutes, and each of the Transaction Documents to which Promedix
  will become a party, when executed and delivered by Promedix, will
  constitute, assuming the

                                      A-8
<PAGE>

  due authorization, execution and delivery by the other parties hereto and
  thereto, the valid and binding obligation of Promedix, enforceable against
  Promedix in accordance with their respective terms, except to the extent
  that enforceability may be limited by applicable bankruptcy,
  reorganization, insolvency, moratorium or other laws affecting the
  enforcement of creditors' rights generally and by general principles of
  equity, regardless of whether such enforceability is considered. For
  purposes of this Agreement, "Transaction Documents" means all documents or
  agreements required to be delivered by any party under this Agreement
  including the Certificate of Merger, the Escrow Agreement, the Voting
  Agreements, the Affiliate Agreements, the Stock Restriction Agreements and
  the Employment Agreements.

     (b) The execution and delivery by Promedix of this Agreement and the
  Transaction Documents to which it is or will become a party does not, and
  the consummation of the transactions contemplated by this Agreement and the
  Transaction Documents to which it is or will become a party will not, (i)
  conflict with, or result in any violation or breach of any provision of the
  Certificate of Incorporation or Bylaws of Promedix, (ii) result in any
  violation or breach of, or constitute (with or without notice or lapse of
  time, or both) a default (or give rise to a right of termination,
  cancellation or acceleration of any obligation or loss of any benefit)
  under any of the terms, conditions or provisions of any note, bond,
  mortgage, indenture, lease, contract or other agreement, instrument or
  obligation to which Promedix is a party or by which it or any of its
  properties or assets may be bound, or (iii) conflict or violate any permit,
  concession, franchise, license, judgment, order, decree, statute, law,
  ordinance, rule or regulation applicable to Promedix or any of its
  properties or assets; except in the case of (ii) and (iii) for any such
  conflicts, violations, defaults, terminations, cancellations or
  accelerations which would not have a Material Adverse Effect on Promedix
  and its Subsidiaries, taken as a whole.

     (c) None of the execution and delivery by Promedix of this Agreement or
  of any other Transaction Document to which Promedix is or will become a
  party or the consummation of the transactions contemplated by this
  Agreement or such Transaction Document will require any consent, approval,
  order or authorization of, or registration, declaration or filing with, any
  court, administrative agency or commission or other governmental authority
  or instrumentality ("Governmental Entity"), except for (i) the filing of
  the Certificate of Merger with the Delaware Secretary of State, (ii)
  filings required under the Hart-Scott-Rodino Antitrust Improvement Act of
  1976, as amended, (iii) such consents, approvals, orders, authorizations,
  registrations, declarations and filings as may be required under applicable
  federal and state securities laws, and (iv) such other consents,
  authorizations, filings, approvals and registrations which are listed on
  the Promedix Disclosure Schedule, or which, if not obtained, would not have
  a Material Adverse Effect on Promedix and its Subsidiaries, taken as a
  whole.

   Section 3.4 Financial Statements; Absence of Undisclosed Liabilities.

     (a) Promedix has delivered to Chemdex copies of Promedix's unaudited
  balance sheet as of July 31, 1999 (the "Most Recent Balance Sheet") and
  statements of operations for the eight-month period then-ended (together
  with the Most Recent Balance Sheet, the "Promedix Interim Financials") and
  Promedix's audited balance sheet as of December 31, 1998, and the related
  audited statements of operations, stockholders' equity and cash flows for
  the year ended December 31, 1998 (collectively, the "Promedix Financial
  Statements").

     (b) The Promedix Financial Statements are in accordance with the books
  and records of Promedix and present fairly in all material respects the
  financial position, results of operations and cash flows of Promedix as of
  their historical dates and for the periods indicated subject to normal
  year-end audit adjustments. The Promedix Financial Statements have been
  prepared in accordance with generally accepted accounting principles
  applied on a basis consistent with prior periods (except as disclosed
  therein, and except for the absence of footnotes in the unaudited Promedix
  Financial Statements). The reserves, if any, reflected on the Promedix
  Financial Statements are adequate in light of the contingencies with
  respect to which they were made.

     (c) Promedix has no material debt, liability, or obligation of any
  nature, whether accrued, absolute, contingent, or otherwise, and whether
  due or to become due, that is not reflected or reserved against in the

                                      A-9
<PAGE>

  Most Recent Balance Sheet, except for those (i) that may have been incurred
  after the date of the Most Recent Balance Sheet, which were incurred in the
  ordinary course of business and are not material both individually and in
  the aggregate to Promedix or its business and (ii) that are not required to
  be reflected therein under generally accepted accounting principles.

   Section 3.5 Tax Matters.

     (a) For purposes of this Section 3.5 and other provisions of this
  Agreement relating to Taxes, the following definitions shall apply:

       (i) The term "Taxes" shall mean all taxes, however denominated,
    including any interest, penalties or other additions to tax that may
    become payable in respect thereof, (A) imposed by any federal,
    territorial, state, local or foreign government or any agency or
    political subdivision of any such government, which taxes shall
    include, without limiting the generality of the foregoing, all income
    or profits taxes (including but not limited to, federal income taxes
    and state income taxes), payroll and employee withholding taxes,
    unemployment insurance, social security taxes, sales and use taxes, ad
    valorem taxes, excise taxes, franchise taxes, gross receipts taxes,
    business license taxes, occupation taxes, real and personal property
    taxes, stamp taxes, environmental taxes, ozone depleting chemicals
    taxes, transfer taxes, workers' compensation, Pension Benefit Guaranty
    Corporation premiums and other governmental charges, and other
    obligations of the same or of a similar nature to any of the foregoing,
    which are required to be paid, withheld or collected, (B) any liability
    for the payment of amounts referred to in (A) as a result of being a
    member of any affiliated, consolidated, combined or unitary group, or
    (C) any liability for amounts referred to in (A) or (B) as a result of
    any obligations to indemnify another person.

       (ii) The term "Returns" shall mean all reports, estimates,
    declarations of estimated tax, information statements and returns
    relating to, or required to be filed in connection with, any Taxes,
    including information returns or reports with respect to backup
    withholding and other payments to third parties.

     (b) All Returns required to be filed prior to the date hereof by or on
  behalf of Promedix have been duly filed on a timely basis, and such Returns
  are true, complete and correct in all material respects. All Taxes shown to
  be payable on such Returns or on subsequent assessments with respect
  thereto, and all payments of estimated Taxes required to be made prior to
  the date hereof by or on behalf of Promedix under Section 6655 of the Code
  or comparable provisions of state, local or foreign law, have been paid in
  full on a timely basis or have been accrued on the Most Recent Balance
  Sheet, and no other Taxes are payable by Promedix with respect to items or
  periods covered by such Returns (whether or not shown on or reportable on
  such Returns). Promedix has withheld and paid over all Taxes required to
  have been withheld and paid over prior to the date hereof, and complied
  with all information reporting and backup withholding requirements,
  including maintenance of required records with respect thereto, in
  connection with amounts paid or owing to any employee, creditor,
  independent contractor, or other third party. There are no liens on any of
  the assets of Promedix with respect to Taxes, other than liens for Taxes
  not yet due and payable or for Taxes that Promedix is contesting in good
  faith through appropriate proceedings and for which appropriate reserves
  have been established on the Most Recent Balance Sheet. Promedix has not at
  any time been (i) a member of an affiliated group of corporations filing
  consolidated, combined or unitary income or franchise tax returns, or (ii)
  a member of any partnership or joint venture for a period for which the
  statue of limitations for any Tax potentially applicable as a result of
  such membership has not expired.

     (c) The amount of Promedix's liability for unpaid Taxes (whether actual
  or contingent) for all periods through the date of the Most Recent Balance
  Sheet does not, in the aggregate, exceed the amount of the current
  liability accruals for Taxes reflected on the Most Recent Balance Sheet,
  and the Most Recent Balance Sheet reflects proper accrual in accordance
  with generally accepted accounting principles applied on a basis consistent
  with prior periods of all liabilities for Taxes payable after the date of
  the Most Recent Balance Sheet attributable to transactions and events
  occurring prior to such date. No liability

                                      A-10
<PAGE>

  for Taxes has been incurred (or prior to Closing will be incurred) since
  such date other than in the ordinary course of business.

     (d) Chemdex has been furnished by Promedix with true and complete copies
  of (i) relevant portions of income tax audit reports, statements of
  deficiencies, closing or other agreements received by or on behalf of
  Promedix relating to Taxes, and (ii) all federal and state income or
  franchise tax Returns and state sales and use tax Returns for or including
  Promedix for all periods since the inception of Promedix. Promedix does not
  do business in or derive income from any state other than states for which
  Returns have been duly filed and furnished to Chemdex.

     (e) The Returns of or including Promedix have never been audited by a
  government or taxing authority, nor has Promedix received notice that any
  such audit is in process, pending or threatened (either in writing or
  verbally, formally or informally). No deficiencies exist or have been
  asserted (either in writing or verbally, formally or informally), and
  Promedix has not received notice (either in writing or verbally, formally
  or informally) that it has not filed a Return or paid Taxes required to be
  filed or paid. Promedix is neither a party to any action or proceeding for
  assessment or collection of Taxes, nor has such event been asserted or
  threatened (either in writing or orally, formally or informally) against
  Promedix or any of its assets. No waiver or extension of any statute of
  limitations is in effect with respect to Taxes or Returns of Promedix.
  Promedix has disclosed on its federal and state income and franchise tax
  Returns all positions taken therein that could give rise to a substantial
  understatement penalty within the meaning of Code Section 6662 or
  comparable provisions of applicable state, local, foreign or other tax
  laws.

     (f) Promedix has not been and is not required to include any material
  adjustment in Taxable income for any Tax period (or portion thereof)
  pursuant to Section 481 or Section 263A of the Code or any comparable
  provision under state or foreign Tax laws as a result of transactions,
  events or accounting methods employed prior to the Closing.

     (g) Promedix is not, nor has it ever been, a party to any tax sharing
  agreement.

     (h) Promedix is not, nor has it been, a United States real property
  holding corporation within the meaning of Section 897(c)(2) of the Code
  during the applicable period specified in Section 897(c)(1)(A)(ii) of the
  Code, and Chemdex is not required to withhold tax by reason of Section 1445
  of the Code. Promedix is not a "consenting corporation" under Section
  341(f) of the Code. Promedix has not entered into any compensatory
  agreements with respect to the performance of services which payment
  thereunder would result in a nondeductible expense to Promedix pursuant to
  Section 280G of the Code or an excise tax to the recipient of such payment
  pursuant to Section 4999 of the Code. Promedix has not agreed to, nor is it
  required to make any adjustment under Code Section 481(a) by reason of, a
  change in accounting method. Promedix is not, nor has it been, a "reporting
  corporation" subject to the information reporting and record maintenance
  requirements of Section 6038A and the regulations thereunder. Promedix is
  in compliance with the terms and conditions of any applicable tax
  exemptions, agreements or orders of any foreign government to which it may
  be subject or which it may have claimed, and the transactions contemplated
  by this Agreement will not have any adverse effect on such compliance.

     (i) The Promedix Disclosure Schedule sets forth accurate and complete
  information regarding Promedix's net operating losses for federal and each
  applicable state income tax purposes. Except as a result of the
  transactions contemplated hereby, Promedix has no net operating losses and
  credit carryovers or other tax attributes currently subject to limitation
  under Sections 382, 383, or 384 of the Code.

   Section 3.6 Absence of Certain Changes or Events. Since December 31, 1998,
Promedix has not:

     (a) suffered any material adverse change in its business, assets
  (including intangible assets), condition (financial or otherwise), or
  results of operations ("Material Adverse Change");

     (b) suffered any damage, destruction or loss, whether covered by
  insurance or not, that has resulted, or could be reasonably expected to
  result, in a Material Adverse Effect on Promedix;


                                      A-11
<PAGE>

     (c) granted or agreed to make any increase in the compensation payable
  or to become payable by Promedix to its officers or employees, except in
  the ordinary course of business, consistent with its past practice;

     (d) declared, set aside or paid any dividend or made any other
  distribution on or in respect of the shares of the capital stock of
  Promedix or declared any direct or indirect redemption, retirement,
  purchase or other acquisition by Promedix of such shares, except pursuant
  to repurchase provisions set forth in stock purchase agreements with
  employees and consultants;

     (e) issued any shares of capital stock of Promedix or any warrants,
  rights, options or entered into any commitment relating to the shares of
  Promedix, except for the (i) issuance of shares of Promedix capital stock
  pursuant to the exercise of Promedix Options and Promedix Warrants listed
  in the Promedix Disclosure Schedule and as permitted under Section 5.2(c),
  (ii) the conversion of outstanding Promedix Preferred Stock, (iii) issuance
  of shares of Promedix capital stock to Strategic Investors that is approved
  in writing in advance by Chemdex, and (iv) conversion of the Convertible
  Debt and exercise of the Promedix Warrants listed in the Promedix
  Disclosure Schedule;

     (f) made any change in the accounting methods or practices it follows,
  whether for general financial or tax purposes, or any change in
  depreciation or amortization policies or rates adopted therein;

     (g) sold, leased, abandoned or otherwise disposed of any real property
  or any machinery, equipment or other operating property with an individual
  net book value in excess of $10,000;

     (h) sold, assigned, transferred, licensed or otherwise disposed of any
  material patent, trademark, trade name, brand name, copyright (or pending
  application for any patent, trademark or copyright) invention, work of
  authorship, process, know-how, formula or trade secret or interest
  thereunder or other intangible asset, except in the ordinary course of
  business;

     (i) permitted or allowed any of its property or assets to be subjected
  to any mortgage, deed of trust, pledge, lien, security interest or other
  encumbrance of any kind (except those permitted under Section 3.7);

     (j) made any capital expenditure or commitment individually in excess of
  $10,000 or in the aggregate in excess of $50,000;

     (k) paid, loaned or advanced any amount to, or sold, transferred or
  leased any properties or assets, or entered into any agreement or
  arrangement with, any of its Affiliates (as defined in Section 3.16),
  officers, directors or stockholders or any affiliate of any of the
  foregoing, except in the case of Promedix's fulfillment business that
  Promedix intends to sell prior to the Closing pursuant to the letter of
  intent, list of assets to be transferred, and list of liabilities to be
  assumed attached to this Agreement as Exhibit H (the "Fulfillment Business
  Sale");

     (l) made any amendment to or terminated any agreement which, if not so
  amended or terminated, would be required to be disclosed on the Promedix
  Disclosure Schedule; or

     (m) agreed to take any action described in this Section 3.6 or which
  would constitute a breach of any of the representations of Promedix
  contained in this Agreement.

   Section 3.7 Title and Related Matters. Promedix owns its properties and
assets, real and personal, free and clear of all mortgages, liens, pledges,
charges or encumbrances of any kind or character, except (1) the lien of
current taxes not yet due and payable, (2) minor imperfections of and
encumbrances on title, if any, as do not materially interfere with the present
use of the property affected thereby and (3) liens securing debt reflected on
the Most Recent Balance Sheet (collectively, "Permitted Encumbrances"). The
equipment of Promedix used in the operation of its business is, taken as a
whole, (i) adequate for the business conducted by Promedix and (ii) in good
operating condition and repair, ordinary wear and tear excepted. All personal
property leases to which Promedix is a party are valid, binding, and
enforceable against the parties thereto and in effect in accordance with their
respective terms. To the knowledge of Promedix, there is not under any of such
leases any existing default or event of default or event which, with notice or
lapse of time or both, would

                                      A-12
<PAGE>

constitute a default. The Promedix Disclosure Schedule contains a description
of all items of personal property with an individual net book value in excess
of $2,500 and real property leased by Promedix, describing its interest in said
property. True and correct copies of Promedix's real property and personal
property leases have been provided to Chemdex or its representatives.

   Section 3.8 Proprietary Rights.

     (a) Promedix owns all right, title and interest in and to, or otherwise
  possesses legally sufficient rights to use, all patents, copyrights,
  technology, software, software tools, know-how, processes, trade secrets,
  trademarks, service marks, trade names, Internet domain names and other
  proprietary rights used in the conduct of Promedix's business as conducted
  to the date of this Agreement and as reasonably expected to be conducted
  following the date hereof, including, without limitation, the technology,
  information, databases, data lists, data compilations, and all proprietary
  rights developed or discovered or used in connection with or contained in
  all versions and implementations of Promedix's World Wide Web sites
  (including www.promedix.com and the other domain names listed in the
  Promedix Disclosure Schedule) or any product which has been or is being
  distributed or sold by Promedix or currently is under development by
  Promedix or has previously been under development by Promedix
  (collectively, including such Web sites, the "Promedix Products"), free and
  clear of all liens, claims and encumbrances (including without limitation
  licensing and distribution rights) other than Permitted Encumbrances (all
  of which are referred to as "Promedix Proprietary Rights"). The Promedix
  Disclosure Schedule contains an accurate and complete (i) description of
  all patents, trademarks (with separate listings of registered and
  unregistered trademarks), trade names, Internet domain names and registered
  copyrights in or related to the Promedix Products or otherwise included in
  the Promedix Proprietary Rights and all applications and registration
  statements therefor, including the jurisdictions in which each such
  Promedix Proprietary Right has been issued or registered or in which any
  such application of such issuance and registration has been filed,
  (ii) list of all licenses and other agreements with third parties (the
  "Third Party Licenses") relating to any material patents, copyrights, trade
  secrets, software, inventions, technology, know-how, processes or other
  proprietary rights that Promedix is licensed or otherwise authorized by
  such third parties to use, market, distribute or incorporate in Promedix
  Products (such patents, copyrights, trade secrets, software, inventions,
  technology, know-how, processes or other proprietary rights are
  collectively referred to as the "Third Party Technology") and (iii) list of
  all licenses and other agreements with third parties relating to any
  material information, compilations, data lists or databases that Promedix
  is licensed or otherwise authorized by such third parties to use, market,
  disseminate distribute or incorporate in Promedix Products. All of
  Promedix's patents, copyrights, trademarks, trade names or Internet domain
  name registrations related to or in the Promedix Products are valid and in
  full force and effect, and consummation of the transactions contemplated by
  this Agreement will not alter or impair any such rights. No claims have
  been asserted or threatened against Promedix (and Promedix is not aware of
  any claims which are likely to be asserted or threatened against Promedix
  or which have been asserted or threatened against others relating to
  Promedix Proprietary Rights or Promedix Products) by any person challenging
  Promedix's use, possession, manufacture, sale or distribution of Promedix
  Products under any Promedix Proprietary Rights (including, without
  limitation, the Third Party Technology) or challenging or questioning the
  validity or effectiveness of any material license or agreement relating
  thereto (including, without limitation, the Third Party Licenses) or
  alleging a violation of any person's or entity's privacy, personal or
  confidentiality rights. Promedix knows of no valid basis for any claim of
  the type specified in the immediately preceding sentence which could in any
  material way relate to or interfere with the continued enhancement and
  exploitation by Promedix of any of the Promedix Products. None of the
  Promedix Products nor the use or exploitation of any Promedix Proprietary
  Rights in Promedix's current business infringes on the rights of or
  constitutes misappropriation of any proprietary information or intangible
  property right of any third person or entity, including without limitation
  any patent, trade secret, copyright, trademark or trade name, and except as
  set forth on the Promedix Disclosure Schedule, Promedix has not been sued
  or named in any suit, action or proceeding which involves a claim of such
  infringement, misappropriation or unfair competition.


                                      A-13
<PAGE>

     (b) Promedix has not granted any third party any right to reproduce,
  distribute, market or exploit any of the Promedix Products or any
  adaptations, translations, or derivative works based on the Promedix
  Products or any portion thereof. Except with respect to the rights of third
  parties to the Third Party Technology, no third party has any express right
  to reproduce, distribute, market or exploit any works or materials of which
  any of the Promedix Products are a "derivative work" as that term is
  defined in the United States Copyright Act, Title 17, U.S.C. Section 101.

     (c) All material designs, drawings, specifications, source code, object
  code, scripts, documentation, flow charts, diagrams, data lists, databases,
  compilations and information incorporating, embodying or reflecting any of
  the Promedix Products at any stage of their development (the "Promedix
  Components") were written, developed and created solely and exclusively by
  employees of Promedix without the assistance of any third party or entity
  or were created by third parties who assigned ownership of their rights to
  Promedix by means of valid and enforceable confidentiality and invention
  assignment agreements, copies of which have been delivered to Chemdex.
  Promedix has at all times used commercially reasonable efforts customary in
  its industry to treat the Promedix Proprietary Rights related to Promedix
  Products and Promedix Components as containing trade secrets and has not
  disclosed or otherwise dealt with such items in a manner intended or
  reasonably likely to cause the loss of such trade secrets by release into
  the public domain.

     (d) To Promedix's knowledge, after due investigation, no employee,
  contractor or consultant of Promedix is in violation in any material
  respect of any term of any written employment contract, patent disclosure
  agreement or any other written contract or agreement relating to the
  relationship of any such employee, consultant or contractor with Promedix
  or, to Promedix's knowledge, any other party because of the nature of the
  business conducted by Promedix or proposed to be conducted by Promedix. The
  Promedix Disclosure Schedule lists all employees, contractors and
  consultants who have participated in any way in the development of any
  material portion of the Promedix Products or the Promedix Proprietary
  Rights.

     (e) Each person presently or previously employed by Promedix (including
  independent contractors, if any) with access authorized by Promedix to
  confidential information of Promedix has executed a confidentiality and
  non-disclosure agreement pursuant to the form of agreement previously
  provided to Chemdex or its representatives.

     (f) No product liability or warranty claims have been communicated in
  writing to or threatened against Promedix.

     (g) To Promedix's knowledge, there is no material unauthorized use,
  disclosure, infringement or misappropriation of any Promedix Proprietary
  Rights, or any Third Party Technology to the extent licensed by or through
  Promedix, by any third party, including any employee or former employee of
  Promedix. Promedix has not entered into any agreement to indemnify any
  other person against any charge of infringement of any Promedix Proprietary
  Rights, other than indemnification agreements contained in Promedix's
  standard form of license agreement in the ordinary course of business.

     (h) Promedix has taken all steps customary and reasonable in the
  industry to protect and preserve the confidentiality and proprietary nature
  of all Intellectual Property and other confidential information not
  otherwise protected by patents, patent applications or copyright
  ("Confidential Information"). All use, disclosure or appropriation by
  Promedix or, to the best knowledge of Promedix, by another party pursuant
  to rights granted to it by Promedix, of Confidential Information owned by
  Promedix to a third party has been pursuant to the terms of a written
  agreement between Promedix and such third party. All use, disclosure or
  appropriation by Promedix of Confidential Information not owned by Promedix
  has been pursuant to the terms of a written agreement between Promedix and
  the owner of such Confidential Information, or is otherwise lawful.

                                      A-14
<PAGE>

   Section 3.9 Employee Benefit Plans.

     (a) The Promedix Disclosure Schedule lists, with respect to Promedix and
  any trade or business (whether or not incorporated) which is treated as a
  single employer with Promedix (an "ERISA Affiliate") within the meaning of
  Section 414(b), (c), (m) or (o) of the Code, (i) all employee benefit plans
  (as defined in Section 3(3) of the Employee Retirement Income Security Act
  of 1974, as amended ("ERISA"), (ii) each loan to a non-officer employee,
  loans to officers and directors and any stock option, stock purchase,
  phantom stock, stock appreciation right, supplemental retirement,
  severance, sabbatical, medical, dental, vision care, disability, employee
  relocation, cafeteria benefit (Code Section 125) or dependent care (Code
  Section 129), life insurance or accident insurance plans, programs or
  arrangements, (iii) all bonus, pension, profit sharing, savings, deferred
  compensation or incentive plans, programs or arrangements, (iv) other
  fringe or employee benefit plans, programs or arrangements that apply to
  senior management of Promedix and that do not generally apply to all
  employees, and (v) any current or former employment or executive
  compensation or severance agreements, written or otherwise, for the benefit
  of, or relating to, any present or former employee, consultant or director
  of Promedix as to which (with respect to any of items (i) through (v)
  above) any potential material liability is borne by Promedix (together, the
  "Promedix Employee Plans").

     (b) Promedix has delivered to Chemdex or its representatives a copy of
  each of the Promedix Employee Plans and related plan documents (including
  trust documents, insurance policies or contracts, employee booklets,
  summary plan descriptions and other authorizing documents, and, to the
  extent still in its possession, any material employee communications
  relating thereto) and has, with respect to each Promedix Employee Plan
  which is subject to ERISA reporting requirements, provided copies of any
  Form 5500 reports filed for the last three plan years. Any Promedix
  Employee Plan intended to be qualified under Section 401(a) of the Code has
  either obtained from the Internal Revenue Service a favorable determination
  letter as to its qualified status under the Code, including all amendments
  to the Code effected by the Tax Reform Act of 1986 and subsequent
  legislation, or has applied to the Internal Revenue Service for such a
  determination, notification or opinion letter prior to the expiration of
  the requisite period under applicable Treasury Regulations or Internal
  Revenue Service pronouncements in which to apply for such determination,
  notification or opinion letter and to make any amendments necessary to
  obtain a favorable determination. Promedix has also furnished Chemdex with
  the most recent Internal Revenue Service determination, notification or
  opinion letter issued with respect to each such Promedix Employee Plan, and
  nothing has occurred since the issuance of each such letter which could
  reasonably be expected to cause the loss of the tax-qualified status of any
  Promedix Employee Plan subject to Code Section 401(a).

     (c) Except as required by Section 4980B of the Code and Section 601 of
  ERISA, (i) none of the Promedix Employee Plans promises or provides retiree
  medical or other retiree welfare benefits to any person; (ii) there has
  been no "prohibited transaction," as such term is defined in Section 406 of
  ERISA and Section 4975 of the Code, with respect to any Promedix Employee
  Plan; (iii) each Promedix Employee Plan has been administered in all
  material respects in accordance with its terms and in compliance with the
  requirements prescribed by any and all statutes, rules and regulations
  (including ERISA and the Code), and Promedix and each subsidiary or ERISA
  Affiliate have performed all material obligations required to be performed
  by them under, are not in any material respect in default, under or
  violation of, and have no knowledge of any material default or violation by
  any other party to, any of the Promedix Employee Plans; (iv) neither
  Promedix nor any subsidiary or ERISA Affiliate is subject to any liability
  or penalty under Sections 4976 through 4980 of the Code or Title I of ERISA
  with respect to any of the Promedix Employee Plans; (v) all contributions
  required to be made by Promedix or any subsidiary or ERISA Affiliate to any
  Promedix Employee Plan have been made on or before their due dates and a
  reasonable amount has been accrued for contributions to each Promedix
  Employee Plan for the current plan years; (vi) with respect to each
  Promedix Employee Plan, no "reportable event" within the meaning of Section
  4043 of ERISA (excluding any such event for which the thirty (30) day
  notice requirement has been waived under the regulations to Section 4043 of
  ERISA) nor any event described in Section 4062,

                                      A-15
<PAGE>

  4063 or 4041 of ERISA has occurred; and (vii) no Promedix Employee Plan is
  covered by, and neither Promedix nor any subsidiary or ERISA Affiliate has
  incurred or expects to incur any material liability under Title IV of ERISA
  or Section 412 of the Code. With respect to each Promedix Employee Plan
  subject to ERISA as either an employee pension plan within the meaning of
  Section 3(2) of ERISA or an employee welfare benefit plan within the
  meaning of Section 3(1) of ERISA, Promedix has prepared in good faith and
  timely filed all requisite governmental reports (which were true and
  correct as of the date filed) and has properly and timely filed and
  distributed or posted all notices and reports to employees required to be
  filed, distributed or posted with respect to each such Promedix Employee
  Plan. No suit, administrative proceeding, action or other litigation has
  been brought, or to the knowledge of Promedix is threatened, against or
  with respect to any such Promedix Employee Plan, including any audit or
  inquiry by the IRS or United States Department of Labor. Neither Promedix
  nor any ERISA Affiliate is a party to, or has made any contribution to or
  otherwise incurred any obligation under, any "multi-employer plan" as
  defined in Section 3(37) of ERISA.

     (d) With respect to each Promedix Employee Plan, Promedix has complied
  in all material respects with (i) the applicable health care continuation
  and notice provisions of the Consolidated Omnibus Budget Reconciliation Act
  of 1985 ("COBRA") and the proposed regulations thereunder, (ii) the
  applicable requirements of the Family Leave Act of 1993 and the regulations
  thereunder, and (iii) the applicable requirements of the Health Insurance
  Portability and Accountability Act of 1996 ("HIPAA") and the temporary
  regulations thereunder.

     (e) The consummation of the transactions contemplated by this Agreement
  will not (i) entitle any current or former employee or other service
  provider of Promedix or any other ERISA Affiliate to severance benefits or
  any other payment (including, without limitation, unemployment
  compensation, golden parachute or bonus), except as expressly provided in
  this Agreement, or (ii) accelerate the time of payment or vesting of any
  such benefits, or (iii) increase or accelerate any benefits or the amount
  of compensation due any such employee or service provider.

     (f) There has been no amendment to, written interpretation or
  announcement (whether or not written) by Promedix or other ERISA Affiliate
  relating to, or change in participation or coverage under, any Promedix
  Employee Plan which would materially increase the expense of maintaining
  such Plan above the level of expense incurred with respect to that Plan for
  the most recent fiscal year included in the Promedix Financial Statements.

   Section 3.10 Bank Accounts. The Promedix Disclosure Schedule sets forth the
names and locations of all banks, trust companies, savings and loan
associations, and other financial institutions at which Promedix maintains
accounts of any nature and the names of all persons authorized to draw thereon
or make withdrawals therefrom.

   Section 3.11 Contracts.

     (a) Except for the contracts listed in Schedule 3.11(a) to the Promedix
  Disclosure Schedule (the "Material Contracts"):

       (i) Promedix has no agreements, contracts or commitments that
    provide for the sale, licensing or distribution by Promedix of any
    Promedix Products or Promedix Proprietary Rights. Without limiting the
    foregoing, except as set forth on the Promedix Disclosure Schedule,
    Promedix has not granted to any third party (including, without
    limitation, original equipment manufacturers ("OEMs") and site-license
    customers) any rights to reproduce, manufacture or distribute any of
    the Promedix Products, nor has Promedix granted to any third party any
    exclusive rights of any kind (including, without limitation,
    exclusivity with regard to categories of advertisers on Promedix's
    World Wide Web site, territorial exclusivity or exclusivity with
    respect to particular versions, implementations or translations of any
    of the Promedix Products), nor has Promedix granted any third party any
    right to market any of the Promedix Products under any private label or
    "OEM" arrangements, nor has Promedix granted any license of any
    Promedix trademarks or service marks.

                                      A-16
<PAGE>

       (ii) Promedix has no Third Party Licenses.

       (iii) Promedix has no agreements, contracts or commitments that call
    for fixed and/or contingent payments or expenditures by or to Promedix
    in excess of $10,000 (including, without limitation, any advertising or
    revenue sharing arrangement).

       (iv) Promedix has no outstanding sales or advertising contract,
    commitment or proposal (including, without limitation, insertion
    orders, slotting agreements or other agreements under which Promedix
    has allowed third parties to advertise on or otherwise be included in
    Promedix's World Wide Web sites) that Promedix currently expects to
    result in any loss to Promedix upon completion or performance thereof.

       (v) Promedix has no outstanding agreements, contracts or commitments
    with officers, employees, agents, consultants, advisors, salesmen,
    sales representatives, distributors or dealers that are not cancelable
    by Promedix "at will" and without liability, penalty or premium.

       (vi) Promedix has no employment, independent contractor or similar
    agreement, contract or commitment that is not terminable on thirty (30)
    days' notice or less without penalty, liability or premium of any type,
    including, without limitation, severance or termination pay.

       (vii) Promedix has no currently effective collective bargaining or
    union agreements, contracts or commitments.

       (viii) Promedix is not restricted by agreement from competing with
    any person or from carrying on its business anywhere in the world.

       (ix) Promedix has not guaranteed any obligations of other persons or
    made any agreements to acquire or guarantee any obligations of other
    persons.

       (x) Promedix has no outstanding loan or advance to any person; nor
    is it party to any line of credit, standby financing, revolving credit
    or other similar financing arrangement of any sort which would permit
    the borrowing by Promedix of any sum.

       (xi) Promedix has no agreements pursuant to which Promedix has
    agreed to manufacture for, supply to or distribute to any third party
    any Promedix Products or Promedix Components.

   True and correct copies of each document or instrument listed on the
Promedix Disclosure Schedule pursuant to this Section 3.11(a) have been
provided to Chemdex or its representatives.

     (b)  All of the Material Contracts listed on the Promedix Disclosure
  Schedule are valid, binding, in full force and effect, and enforceable by
  Promedix in accordance with their respective terms. Except as disclosed in
  the Promedix Disclosure Schedule, no Material Contract contains any
  liquidated damages, penalty or similar provision. To the knowledge of
  Promedix, no party to any such Material Contract intends to cancel,
  withdraw, modify or amend such contract, agreement or arrangement.

     (c) Promedix is not in default under or in breach or violation of, nor,
  to Promedix's knowledge, is there any valid basis for any claim of default
  by Promedix under, or breach or violation by Promedix of, any material
  provision of any Material Contract. To Promedix's knowledge, no other party
  is in default under or in breach or violation of, nor is there any valid
  basis for any claim of default by any other party under or any breach or
  violation by any other party of, any Material Contract.

     (d) Except as specifically indicated on the Promedix Disclosure
  Schedule, none of the Material Contracts provides for indemnification by
  Promedix of any third party. No claims have been made or threatened that
  would require indemnification by Promedix, and Promedix has not paid any
  amounts to indemnify any third party as a result of indemnification
  requirements of any kind.

   Section 3.12 Compliance With Law. Promedix and the operation of its business
are in compliance in all material respects with all applicable laws and
regulations material to the operation of its business. Neither

                                      A-17
<PAGE>

Promedix nor, to Promedix's knowledge, any of its employees has directly or
indirectly paid or delivered any fee, commission or other sum of money or item
of property, however characterized, to any finder, agent, government official
or other party in the United States or any other country, that was or is in
violation of any federal, state, or local statute or law or of any statute or
law of any other country having jurisdiction. Promedix has not participated
directly or indirectly in any boycotts or other similar practices affecting any
of its customers. Promedix has complied in all material respects at all times
with any and all applicable federal, state and foreign laws, rules,
regulations, proclamations and orders relating to the importation or
exportation of its products, except for such noncompliance as would not in the
aggregate reasonably be expected to have a Material Adverse Effect on Promedix.
Promedix has complied with all applicable federal, state and local laws, and
regulations relating to the collection and use of user information gathered in
the course of Promedix's operations, and Promedix has at all times complied
with all rules, policies and procedures established by Promedix from time to
time with respect to the foregoing.

   Section 3.13 Labor Difficulties; No Discrimination.

     (a) Promedix is not engaged in any unfair labor practice and is not in
  material violation of any applicable laws respecting employment and
  employment practices, terms and conditions of employment, and wages and
  hours. There is no unfair labor practice complaint against Promedix
  actually pending or, to the knowledge of Promedix, threatened before the
  National Labor Relations Board. There is no strike, labor dispute,
  slowdown, or stoppage actually pending or, to the knowledge of Promedix,
  threatened against Promedix. To the knowledge of Promedix, no union
  organizing activities are taking place with respect to the business of
  Promedix. No grievance, or any arbitration proceeding arising out of or
  under any collective bargaining agreement is pending and, to the knowledge
  of Promedix, no claims therefor exist. No collective bargaining agreement
  that is binding on Promedix restricts it from relocating or closing any of
  its operations. Promedix has not experienced any material work stoppage or
  other material labor difficulty.

     (b) There is and has not been any claim against Promedix or its officers
  or employees, or to Promedix's knowledge, threatened against Promedix or
  its officers or employees, based on actual or alleged race, age, sex,
  disability or other harassment or discrimination, or similar tortious
  conduct, or based on actual or alleged breach of contract with respect to
  any person's employment by Promedix, nor, to the knowledge of Promedix, is
  there any basis for any such claim.

     (c) There are no pending claims against Promedix under any workers
  compensation plan or policy or for long term disability. Promedix has no
  material obligations under COBRA with respect to any former employees or
  qualifying beneficiaries thereunder. There are no proceedings pending or,
  to the knowledge of Promedix, threatened, between Promedix and any of its
  employees, which proceedings have or could reasonably be expected to have a
  Material Adverse Effect on Promedix.

   Section 3.14 Insider Transactions. To the knowledge of Promedix, no
affiliate ("Affiliate") as defined in Rule 12b-2 under the Securities Exchange
Act of 1934, as amended (the "Exchange Act") of Promedix has any interest in
any equipment or other property, real or personal, tangible or intangible of
Promedix, including, without limitation, any Promedix Proprietary Rights or any
creditor, supplier, customer, manufacturer, agent, representative, or
distributor of Promedix Products; provided, however, that no such Affiliate or
other person shall be deemed to have such an interest solely by virtue of the
ownership of less than 1% of the outstanding stock or debt securities of any
publicly-held company, the stock or debt securities of which are traded on a
recognized stock exchange or quoted on the Nasdaq Stock Market.

   Section 3.15 Employees, Independent Contractors and Consultants. The
Promedix Disclosure Schedule lists all past and all currently effective written
or oral consulting, independent contractor and/or employment agreements and
other material agreements concluded with individual employees, independent
contractors or consultants to which Promedix is a party. True and correct
copies of all such written agreements have been provided to Chemdex or its
representatives. All independent contractors have been properly classified as
independent contractors for the purposes of federal and applicable state tax
laws, laws applicable to employee benefits and other applicable law. All
salaries and wages paid by Promedix are in compliance in

                                      A-18
<PAGE>

all material respects with applicable federal, state and local laws. Also shown
on the Promedix Disclosure Schedule are the names, positions and salaries or
rates of pay, including bonuses, of all persons presently employed by Promedix.

   Section 3.16 Insurance. The Promedix Disclosure Schedule contains a list of
the principal policies of fire, liability and other forms of insurance
currently or previously held by Promedix, and all claims made by Promedix under
such policies. To the knowledge of Promedix, Promedix has not done anything,
either by way of action or inaction, which might invalidate such policies in
whole or in part. There is no claim pending under any of such policies or bonds
as to which coverage has been questioned, denied or disputed by the
underwriters of such policies or bonds. All premiums due and payable under all
such policies and bonds have been paid and Promedix is otherwise in compliance
with the terms of such policies and bonds in all material respects. Promedix
has no knowledge of any threatened termination of, or material premium increase
with respect to, any of such policies.

   Section 3.17 Litigation. There is no private or governmental action, suit,
proceeding, claim, arbitration or investigation pending before any agency,
court or tribunal, foreign or domestic, or, to the knowledge of Promedix,
threatened against Promedix or any of its properties or any of its officers or
directors (in their capacities as such). There is no judgment, decree or order
against Promedix, or, to the knowledge of Promedix, any of its directors or
officers (in their capacities as such). To Promedix's knowledge, no
circumstances exist that could reasonably be expected to result in a claim
against Promedix as a result of the conduct of Promedix's business (including,
without limitation, any claim of infringement of any intellectual property
right).

   Section 3.18 Governmental Authorizations and Regulations. Promedix has
obtained each federal, state, county, local or foreign governmental consent,
license, permit, grant, or other authorization of a Governmental Entity (i)
pursuant to which Promedix currently operates or holds any interest in any of
its properties or (ii) that is required for the operation of Promedix's
business or the holding of any such interest, and all of such authorizations
are in full force and effect, except when the failure to obtain such
authorization could not be reasonably expected to have a Material Adverse
Effect.

   Section 3.19 Subsidiaries. Promedix has no Subsidiaries. Promedix does not
own or control (directly or indirectly) any capital stock, bonds or other
securities of, and does not have any proprietary interest in, any other
corporation, general or limited partnership, firm, association or business
organization, entity or enterprise, and Promedix does not control (directly or
indirectly) the management or policies of any other corporation, partnership,
firm, association or business organization, entity or enterprise.

   Section 3.20 Compliance with Environmental Requirements. Promedix has
obtained all permits, licenses and other authorizations which are required
under federal, state and local laws applicable to Promedix and relating to
pollution or protection of the environment, including laws or provisions
relating to emissions, discharges, releases or threatened releases of
pollutants, contaminants, or hazardous or toxic materials, substances, or
wastes into air, surface water, groundwater, or land, or otherwise relating to
the manufacture, processing, distribution, use, treatment, storage, disposal,
transport, or handling of pollutants, contaminants or hazardous or toxic
materials, substances, or wastes or which are intended to assure the safety of
employees, workers or other persons, except where the failure to obtain such
authorizations could not be reasonably expected to have a Material Adverse
Effect. Promedix is in compliance in all material respects with all terms and
conditions of all such permits, licenses and authorizations. There are no
conditions, circumstances, activities, practices, incidents, or actions known
to Promedix which could reasonably be expected to form the basis of any claim,
action, suit, proceeding, hearing, or investigation of, by, against or relating
to Promedix, based on or related to the manufacture, processing, distribution,
use, treatment, storage, disposal, transport, or handling, or the emission,
discharge, release or threatened release into the environment, of any
pollutant, contaminant, or hazardous or toxic substance, material or waste, or
relating to the safety of employees, workers or other persons.


                                      A-19
<PAGE>

   Section 3.21 Trade Regulation. All of the prices charged by Promedix in
connection with the marketing or sale of any products or services have been in
compliance in all material respects with all applicable laws and regulations.
No claims have been threatened in writing against Promedix with respect to
wrongful termination of any dealer, distributor or any other marketing entity,
discriminatory pricing, price fixing, unfair competition, false advertising, or
any other violation of any laws or regulations relating to anti-competitive
practices or unfair trade practices of any kind, and to Promedix's knowledge,
no specific situation, set of facts, or occurrence provides any basis for any
such claim.

   Section 3.22 Year 2000 Compliance. Except as would not reasonably be
expected to have a Material Adverse Effect on Promedix, all Information
Technology (as defined below) developed by or for Promedix effectively
addresses the Year 2000 issue and will not cause an interruption in the ongoing
operations of Promedix's business on or after January 1, 2000, and Promedix has
received assurances from all of its vendors that all Information Technology
provided to Promedix by its vendors, effectively addresses the Year 2000 issue
and will not cause an interruption in the ongoing operations of Promedix's
business on or after January 1, 2000. For purposes of the foregoing, the term
"Information Technology" shall mean and include all software, hardware,
firmware, telecommunications systems, network systems, embedded systems and
other systems, components and/or services that are owned or used by a party
hereto in the conduct of its business, or purchased by a party hereto from
third party suppliers. In addition, none of the Promedix Products and Promedix
Components will cause an interruption in the ongoing operations of any customer
of Promedix or of the combined company on or after January 1, 2000.

   Section 3.23 Corporate Documents. Promedix has furnished to Chemdex or its
representatives: (a) copies of its Certificate of Incorporation and Bylaws, as
amended to date; (b) its minute book containing consents, actions, and meetings
of the stockholders, the board of directors and any committees thereof; (c) all
material permits, orders, and consents issued by any regulatory agency with
respect to Promedix, or any securities of Promedix, and all applications for
such permits, orders, and consents; and (d) the stock transfer books of
Promedix setting forth all transfers of any capital stock. The corporate minute
books, stock certificate books, stock registers and other corporate records of
Promedix are complete and accurate, and the signatures appearing on all
documents contained therein are the true or facsimile signatures of the persons
purporting to have signed the same.

   Section 3.24 No Brokers. Neither Promedix nor, to Promedix's knowledge, any
Promedix stockholder is obligated for the payment of fees or expenses of any
broker or finder in connection with the origin, negotiation or execution of
this Agreement or the other Transaction Documents or in connection with any
transaction contemplated hereby or thereby.

   Section 3.25 Promedix Action. The Board of Directors of Promedix, by
unanimous written consent or at a meeting duly called and held, has by the
unanimous vote of all directors (i) determined that the Merger is fair and in
the best interests of Promedix and its stockholders, (ii) approved the Merger
and this Agreement in accordance with the provisions of Delaware Law, and (iii)
directed that this Agreement and the Merger be submitted to Promedix
stockholders for their approval and resolved to recommend that Promedix
stockholders vote in favor of the approval of this Agreement and the Merger.

   Section 3.26 Offers. Promedix has suspended or terminated, and has the legal
right to terminate or suspend, all negotiations and discussions of Acquisition
Transactions (as defined in Section 5.5) with parties other than Chemdex.

   Section 3.27 Disclosure. No statements by Promedix contained in this
Agreement, its exhibits and schedules nor in any of the certificates or
documents, including any of the Transaction Documents, delivered or required to
be delivered by Promedix to Chemdex or Sub under this Agreement contains any
untrue statement of a material fact or omits to state a material fact necessary
in order to make the statements contained herein or therein not misleading in
light of the circumstances under which they were made. Promedix has disclosed
to

                                      A-20
<PAGE>

Chemdex all material information of which it is aware relating specifically to
the operations and business of Promedix as of the date of this Agreement or the
transactions contemplated by this Agreement.

   Section 3.28 Registration Statement; Proxy Statement/Prospectus. The
information supplied by Promedix for inclusion in the Form S-4 (or any similar
successor form thereto) Registration Statement (the "Registration Statement")
to be filed with the Securities and Exchange Commission (the "Commission") in
accordance with the Securities Act in connection with the Merger, shall not at
the time the Registration Statement becomes effective under the Securities Act
contain any untrue statement of a material fact or omit to state any material
fact required to be stated therein or necessary in order to make the statements
therein, in light of the circumstances under which they are made, not
misleading. The information supplied by Promedix for inclusion in the proxy
statement/prospectus to be sent to the stockholders of Promedix and Chemdex in
connection with the meeting of Promedix's stockholders to consider the approval
and adoption of this Agreement and the approval of the Merger (the "Promedix
Stockholders' Meeting") and the meeting of Chemdex's stockholders to consider
the approval and adoption of this Agreement and the approval of the Merger (the
"Chemdex Stockholders' Meeting") (such proxy statement/prospectus as amended or
supplemented is referred to herein as the "Proxy Statement/Prospectus") shall
not, on the date the Proxy Statement/Prospectus is first mailed to Promedix's
stockholders or at the time of the Promedix Stockholders' Meeting, contain any
untrue statement of a material fact or omit to state any material fact required
to be stated therein or necessary in order to make the statements therein, in
light of the circumstances under which they are made, not false or misleading;
or omit to state any material fact necessary to correct any statement in any
earlier communication with respect to the solicitation of proxies for the
Promedix Stockholders' Meeting which has become false or misleading. The Proxy
Statement/Prospectus will comply as to form in all material respects with the
provisions of the Securities Act, the Exchange Act and the rules and
regulations thereunder. If at any time prior to the Effective Time any event
relating to Promedix or any of its affiliates, officers or directors should be
discovered by Promedix which is required to be set forth in an amendment to the
Registration Statement or a supplement to the Proxy Statement/Prospectus,
Promedix shall promptly inform Chemdex. Notwithstanding the foregoing, Promedix
makes no representation or warranty with respect to any information supplied by
Chemdex or Sub that is contained in any of the foregoing documents.

                                   ARTICLE IV

               REPRESENTATIONS AND WARRANTIES OF CHEMDEX AND SUB

   Chemdex and Sub jointly and severally represent and warrant to Promedix
that, except as disclosed in a filing with the Securities and Exchange
Commission as of the date of this Agreement (the "Commission"), the statements
contained in this Article IV are true and correct.

   Section 4.1 Organization of Chemdex and Sub. Each of Chemdex and its
Subsidiaries, including Sub, is a corporation duly organized, validly existing
and in good standing under the laws of its respective jurisdiction of
incorporation and has all requisite corporate power to own, lease and operate
its property and to carry on its business as now being conducted and is duly
qualified or licensed to do business and is in good standing in each
jurisdiction in which the failure to be so qualified or licensed would have a
Material Adverse Effect on Chemdex or Sub. The authorized capital stock of Sub
consists of 1,000 shares of Common Stock, all of which are issued and
outstanding, duly paid and nonassessable and are owned by Chemdex free and
clear of all liens, charges and encumbrances.

   Section 4.2 Capitalization.

     (a) The authorized capital stock of Chemdex consists of 175,000,000
  shares of Common Stock, par value $0.00002 per share ("Chemdex Common
  Stock"), and 2,500,000 shares of undesignated Preferred Stock, par value
  $0.00002 per share ("Chemdex Preferred Stock"). As of September 20, 1999,
  there were (i) 32,797,737 shares of Chemdex Common Stock issued and
  outstanding, all of which are validly

                                      A-21
<PAGE>

  issued, fully paid and non-assessable, (ii) no shares of Chemdex Preferred
  Stock issued or outstanding. (iii) options to purchase up to 3,194,363
  shares of Chemdex Common Stock ("Chemdex Options"); (iv) warrants to
  purchase up to 179,999 shares of Chemdex Common Stock; (vi) 2,500,000
  shares of Chemdex Common Stock reserved for future issuance upon conversion
  of the Chemdex Preferred Stock; and (vii) 1,799,398 shares of Chemdex
  Common Stock reserved for issuance upon exercise of options available to be
  granted in the future under the Chemdex 1998 Stock Plan ("Chemdex Stock
  Plan"). All shares of Chemdex Common Stock subject to issuance upon the
  exercise of Chemdex Options, upon issuance on the terms and conditions
  (including payment) specified in the instrument pursuant to which they are
  issuable, will be duly authorized, validly issued, fully paid and
  nonassessable. All outstanding shares of Chemdex Common Stock and
  outstanding Chemdex Options (collectively "Chemdex Securities") were issued
  in compliance with applicable federal and state securities laws. Except as
  disclosed in a filing with the Commission, there are no obligations,
  contingent or otherwise, of Chemdex to repurchase, redeem or otherwise
  acquire any shares of Chemdex Common Stock or Chemdex Preferred Stock or
  make any investment (in the form of a loan, capital contribution or
  otherwise) in any other entity.

     (b) Except as disclosed in a filing with the Commission, there are no
  equity securities of any class or series of Chemdex, or any security
  exchangeable into or exercisable for such equity securities, issued,
  reserved for issuance or outstanding. Except as disclosed in a filing with
  the Commission, there are no options, warrants, equity securities, calls,
  rights, commitments or agreements of any character to which Chemdex is a
  party or by which it is bound obligating Chemdex to issue, deliver or sell,
  or cause to be issued, delivered or sold, additional shares of capital
  stock of Chemdex or obligating Chemdex to grant, extend, accelerate the
  vesting of or enter into any such option, warrant, equity security, call,
  right, commitment or agreement. Except as disclosed in a filing with the
  Commission and as provided in this Agreement and the other Transaction
  Documents, or any transaction contemplated hereby or thereby, there are no
  voting trusts, proxies or other agreements or understandings with respect
  to the voting of the shares of capital stock of Chemdex.

     (c) All Chemdex Options have been issued in accordance with the terms of
  the Chemdex Stock Plan and pursuant to the standard forms of option
  agreement.

     (d) The shares of Chemdex's Common Stock to be issued pursuant to the
  Merger will be duly authorized, validly issued, fully paid, and non-
  assessable and no person will have any preemptive right of subscription or
  purchase in respect thereof.

   Section 4.3 Authority; No Conflict; Required Filings and Consents.

     (a) Each of Chemdex and Sub has all requisite corporate power and
  authority to enter into this Agreement and the other Transaction Documents
  to which it is or will become a party and to consummate the transactions
  contemplated by this Agreement and such Transaction Documents. The
  execution and delivery of this Agreement and such Transaction Documents and
  the consummation of the transactions contemplated by this Agreement and
  such Transaction Documents have been duly authorized by all necessary
  corporate action on the part of Chemdex and Sub. This Agreement has been
  and such Transaction Documents have been or, to the extent not executed as
  of the date hereof, will be duly executed and delivered by Chemdex and Sub.
  This Agreement and each of the Transaction Documents to which Chemdex or
  Sub is a party constitutes, and each of the Transaction Documents to which
  Chemdex or Sub will become a party when executed and delivered by Chemdex
  or Sub will constitute, a valid and binding obligation of Chemdex or Sub,
  enforceable by Promedix against Chemdex or Sub, as the case may be, in
  accordance with its terms, except to the extent that enforceability may be
  limited by applicable bankruptcy, reorganization, insolvency, moratorium or
  other laws affecting the enforcement of creditors' rights generally and by
  general principles of equity, regardless of whether such enforceability is
  considered.

     (b) The execution and delivery by Chemdex or Sub of this Agreement and
  the Transaction Documents to which it is or will become a party does not,
  and consummation of the transactions

                                      A-22
<PAGE>

  contemplated by this Agreement or the Transaction Documents to which it is
  or will become a party will not, (i) conflict with, or result in any
  violation or breach of any provision of the Certificate of Incorporation or
  Bylaws of Chemdex or Sub, (ii) result in any violation or breach of, or
  constitute (with or without notice or lapse of time, or both) a default (or
  give rise to a right of termination, cancellation or acceleration of any
  obligation or loss of any material benefit) under any of the terms,
  conditions or provisions of any note, bond, mortgage, indenture, lease,
  contract or other agreement, instrument or obligation to which Chemdex or
  Sub is a party or by which either of them or any of their properties or
  assets may be bound, or (iii) conflict or violate any permit, concession,
  franchise, license, judgment, order, decree, statute, law, ordinance, rule
  or regulation applicable to Chemdex or Sub or any of their properties or
  assets, except in the case of (ii) and (iii) for any such conflicts,
  violations, defaults, terminations, cancellations or accelerations which
  would not have a Material Adverse Effect on Chemdex and its Subsidiaries,
  taken as a whole.

     (c) Neither the execution and delivery of this Agreement by Chemdex or
  Sub or the Transaction Documents to which Chemdex or Sub is or will become
  a party or the consummation of the transactions contemplated hereby or
  thereby will require any consent, approval, order or authorization of, or
  registration, declaration or filing with, any Governmental Entity, except
  for (i) the filing of the Certificate of Merger with the Delaware Secretary
  of State, (ii) filings required under the Hart-Scott-Rodino Antitrust
  Improvement Act of 1976, as amended, (iii) such consents, approvals,
  orders, authorizations, registrations, declarations and filings as may be
  required under applicable federal and state securities laws and the laws of
  any foreign country, and (iv) such other consents, authorizations, filings,
  approvals and registrations which, if not obtained or made, could be
  expected to have a Material Adverse Effect on Chemdex and its Subsidiaries,
  taken as a whole.

   Section 4.4 Commission Filings; Financial Statements.

     (a) Chemdex has filed with the Commission and made available, and will
  continue to make available, to Promedix or its representatives all forms,
  reports and documents required to be filed by Chemdex with the Commission
  since July 26, 1999 until the Closing (collectively, the "Chemdex
  Commission Reports"). The Chemdex Commission Reports (i) at the time filed,
  complied in all material respects with the applicable requirements of the
  Securities Act of 1933, as amended, (the "Securities Act"), and the
  Exchange Act, as the case may be, and (ii) did not at the time they were
  filed (or if amended or superseded by a filing prior to the date of this
  Agreement, then on the date of such filing) contain any untrue statement of
  a material fact or omit to state a material fact required to be stated in
  such Chemdex Commission Reports or necessary in order to make the
  statements in such Chemdex Commission Reports, in the light of the
  circumstances under which they were made, not misleading.

     (b) Each of the financial statements (including, in each case, any
  related notes) contained in the Chemdex Commission Reports, including any
  Chemdex Commission Reports filed after the date of this Agreement until the
  Closing, complied or will comply as to form in all material respects with
  the applicable published rules and regulations of the Commission with
  respect thereto, was prepared in accordance with generally accepted
  accounting principles applied on a consistent basis throughout the periods
  involved (except as may be indicated in the notes to such financial
  statements or, in the case of unaudited statements, as permitted by Form
  10-Q of the Commission) and fairly presented the consolidated financial
  position of Chemdex and its Subsidiaries as at the respective dates and the
  consolidated results of its operations and cash flows for the periods
  indicated, except that the unaudited interim financial statements were or
  are subject to normal and recurring year-end adjustments which were not or
  are not expected to be material in amount.

   Section 4.5 Compliance with Laws. Chemdex has complied with, is not in
violation of, and has not received any notices of violation with respect to,
any federal, state or local statute, law or regulation with respect to the
conduct of its business, or the ownership or operation of its business, except
for failures to comply or violations which would not have a Material Adverse
Effect on Chemdex and its Subsidiaries, taken as a whole.

                                      A-23
<PAGE>

   Section 4.6 Interim Operations of Sub. Sub was formed by Chemdex solely for
the purpose of engaging in the transactions contemplated by this Agreement, has
engaged in no other business activities and has conducted its operations only
as contemplated by this Agreement. Sub has no liabilities and, except for a
subscription agreement pursuant to which all of its authorized capital stock
was issued to Chemdex, is not a party to any agreement other than this
Agreement.

   Section 4.7 Disclosure. No statements by Chemdex contained in this
Agreement, its exhibits and schedules, or any of the certificates or documents,
including any of the Transaction Documents, required to be delivered by Chemdex
or Sub to Promedix under this Agreement contain any untrue statement of
material fact or omits to state a material fact necessary in order to make the
statements contained herein or therein not misleading in light of the
circumstances under which they were made.

   Section 4.8 Registration Statement; Proxy Statement/Prospectus. The
information supplied by Chemdex or Sub for inclusion in the Registration
Statement shall not at the time the Registration Statement becomes effective
under the Securities Act contain any untrue statement of a material fact or
omit to state any material fact required to be stated therein or necessary in
order to make the statements therein, in light of the circumstances under which
they are made, not misleading. The information supplied by Chemdex or Sub for
inclusion in the Proxy Statement/Prospectus shall not, on the date the Proxy
Statement/Prospectus is first mailed to Promedix's stockholders or at the time
of the Promedix Stockholders' Meeting, contain any untrue statement of a
material fact or omit to state any material fact required to be stated therein
or necessary in order to make the statements therein, in light of the
circumstances under which they are made, not false or misleading; or omit to
state any material fact necessary to correct any statement in any earlier
communication with respect to the solicitation of proxies for the Promedix
Stockholders' Meeting which has become false or misleading. The Proxy
Statement/Prospectus will comply as to form in all material respects with the
provisions of the Securities Act, the Exchange Act and the rules and
regulations thereunder. If at any time prior to the Effective Time any event
relating to Chemdex, Sub or any of their affiliates, officers or directors
should be discovered by Chemdex or Sub which is required to be set forth in an
amendment to the Registration Statement or a supplement to the Proxy
Statement/Prospectus, Chemdex shall promptly inform Promedix. Notwithstanding
the foregoing, Chemdex makes no representation or warranty with respect to any
information supplied by Promedix that is contained in any of the foregoing
documents.

   Section 4.9 No Brokers. None of Chemdex, Sub or, to Chemdex's knowledge, any
Chemdex stockholder is obligated for the payment of fees or expenses of any
broker or finder in connection with the origin, negotiation or execution of
this Agreement or the other Transaction Documents or in connection with any
transaction contemplated hereby or thereby.

   Section 4.10 Chemdex Action. The Board of Directors of Chemdex, by unanimous
written consent or at a meeting duly called and held, has by the unanimous vote
of all directors (i) determined that the Merger is fair and in the best
interests of Chemdex and its stockholders, (ii) approved the Merger and this
Agreement in accordance with the provisions of Delaware Law, and (iii) directed
that this Agreement and the Merger be submitted to Chemdex stockholders for
their approval and resolved to recommend that Chemdex stockholders vote in
favor of the approval of this Agreement and the Merger.

   Section 4.11 Offers. Chemdex has suspended or terminated, and has the legal
right to terminate or suspend, all negotiations and discussions of any Chemdex
Acquisition Transactions (as defined in Section 6.11) with parties other than
Promedix.

   Section 4.12 Litigation. There is no private or governmental action, suit,
proceeding, claim, arbitration or investigation pending before any agency,
court or tribunal, foreign or domestic, or, to the knowledge of Chemdex,
threatened against Chemdex or any of its properties or any of its officers or
directors (in their capacities as such) that would be reasonably likely to
materially interfere or delay Chemdex's ability to consummate the transactions
contemplated by this Agreement.


                                      A-24
<PAGE>

   Section 4.13 Absence of Certain Changes or Events. Since June 30, 1999,
Chemdex has not:

     (a) suffered any Material Adverse Change;

     (b) suffered any damage, destruction or loss, whether covered by
  insurance or not, that has resulted, or could be reasonably expected to
  result, in a Material Adverse Effect on Chemdex;

     (c) declared, set aside or paid any dividend or made any other
  distribution on or in respect of the shares of the capital stock of Chemdex
  or declared any direct or indirect redemption, retirement, purchase or
  other acquisition by Chemdex of such shares, except pursuant to repurchase
  provisions set forth in stock purchase agreements with employees and
  consultants; or

     (d) agreed to take any action described in this Section 4.13 or which
  would constitute a breach of any of the representations of Chemdex
  contained in this Agreement.

                                   ARTICLE V

                        PRECLOSING COVENANTS OF PROMEDIX

   Section 5.1 Advice of Changes. Promedix will promptly advise Chemdex in
writing of any event known to Promedix occurring subsequent to the date of this
Agreement which would render any representation or warranty of Promedix
contained in this Agreement, if made on or as of the date of such event or the
Closing Date, untrue or inaccurate in any material respect.

   Section 5.2 Operation of Business. During the period from the date of this
Agreement and continuing until the earlier of the termination of the Agreement
or the Effective Time, Promedix agrees (except to the extent that Chemdex shall
otherwise consent in writing), to carry on its business in the usual, regular
and ordinary course in substantially the same manner as previously conducted,
to pay its debts and taxes when due, subject to good faith disputes over such
debts or taxes, to pay or perform other obligations when due, and, to the
extent consistent with such business, use all reasonable efforts consistent
with past practices and policies to preserve intact its present business
organization, keep available the services of its present officers and employees
and preserve its relationships with customers, suppliers, distributors,
licensors, licensees, and others having business dealings with it, to the end
that its goodwill and ongoing businesses would be unimpaired at the Effective
Time. Promedix shall promptly notify Chemdex of any event or occurrence not in
the ordinary course of business of Promedix. Except as expressly contemplated
by this Agreement or the Promedix Disclosure Schedule, Promedix shall not,
without the prior written consent of Chemdex:

     (a) except as otherwise contemplated by Section 6.5(b), accelerate,
  amend or change the period of exercisability or the vesting schedule of
  Promedix Restricted Shares or Promedix Options granted under any employee
  stock plan or agreements or authorize cash payments in exchange for any
  Promedix Restricted Shares or Promedix Options granted under any of such
  plans except as specifically required by the terms of such plans or any
  related agreements or any such agreements in effect as of the date of this
  Agreement and disclosed in the Promedix Disclosure Schedule;

     (b) declare or pay any dividends on or make or agree to make any other
  distributions (whether in cash, stock or property) in respect of any of its
  capital stock, or split, combine or reclassify any of its capital stock or
  issue or authorize the issuance of any other securities in respect of, in
  lieu of or in substitution for shares of capital stock of such party, or
  purchase or otherwise acquire, directly or indirectly, any shares of its
  capital stock except from former employees, directors and consultants in
  accordance with agreements providing for the repurchase of shares in
  connection with any termination of service by such party;

     (c) issue, deliver or sell or authorize or propose the issuance,
  delivery or sale of, or purchase or propose the purchase of, any shares of
  its capital stock or securities convertible into shares of its capital
  stock, or subscriptions, rights, warrants or options to acquire, or other
  agreements or commitments of any

                                      A-25
<PAGE>

  character obligating it to issue any such shares or other convertible
  securities, other than (i) the issuance of (A) shares of Promedix Common
  Stock issuable upon exercise of Promedix Options, and Promedix Warrants
  which are outstanding on the date of this Agreement, (B) shares of Promedix
  Common Stock issuable upon conversion of shares of Promedix Preferred
  Stock, or (C) shares of Promedix capital stock upon conversion of the
  Convertible Debt; (ii) the repurchase of shares of Common Stock from
  terminated employees pursuant to the terms of outstanding stock restriction
  or similar agreements; or (iii) the grant of options or issuance of
  restricted stock under the Promedix Stock Option Plan at fair market value
  in the ordinary course of business in accordance with prior practice.

     (d) acquire or agree to acquire by merging or consolidating with, or by
  purchasing a substantial equity interest in or substantial portion of the
  assets of, or by any other manner, any business or any corporation,
  partnership or other business organization or division, or otherwise
  acquire or agree to acquire any assets;

     (e) sell, lease, license or otherwise dispose of any of its properties
  or assets which are material, individually or in the aggregate, to the
  business of Promedix, except nonexclusive licenses of Promedix's products
  and services in the ordinary course of business consistent with past
  practice;

     (f) (i) increase or agree to increase the compensation payable or to
  become payable to its officers or employees (except to non-officer
  employees in the ordinary course of business consistent with past
  practice), (ii) grant any additional severance or termination pay to, or
  enter into any employment or severance agreements with, officers, employees
  or agents, (iii) enter into any collective bargaining agreement, or (iv)
  establish, adopt, enter into or amend in any material respect any bonus,
  profit sharing, thrift, compensation, stock option, restricted stock,
  pension, retirement, deferred compensation, employment, termination,
  severance or other plan, trust, fund, policy or arrangement for the benefit
  of any directors, officers or employees;

     (g) revalue any of its assets, including writing down the value of
  inventory or writing off notes or accounts receivable;

     (h) incur, in excess of $25,000, any indebtedness for borrowed money or
  guarantee any such indebtedness or issue or sell any debt securities or
  warrants or rights to acquire any debt securities or guarantee any debt
  securities of others;

     (i) amend or propose to amend its Certificate of Incorporation or
  Bylaws;

     (j) incur or commit to incur any capital expenditures in excess of
  $50,000 in the aggregate or in excess of $25,000 as to any individual
  matter;

     (k) lease, license, sell, transfer or encumber or permit to be
  encumbered any asset, Promedix Proprietary Right or other property
  associated with the business of Promedix (including sales or transfers to
  Affiliates of Promedix), except nonexclusive licenses of Promedix's
  products and services in the ordinary course of business consistent with
  prior practice;

     (1) enter into any lease or contract for the purchase or sale of any
  property, real or personal, except in the ordinary course of business
  consistent with past practice;

     (m) fail to maintain its equipment and other assets in good working
  condition and repair according to the standards it has maintained up to the
  date of this Agreement, subject only to ordinary wear and tear;

     (n) change accounting methods;

     (o) amend or terminate any material contract, agreement or license to
  which it is a party;

     (p) loan any amount to any person or entity, or guaranty or act as a
  surety for any obligation;

     (q) waive or release any material right or claim;


                                      A-26
<PAGE>

     (r) make or change any Tax or accounting election, change any annual
  accounting period, adopt or change any accounting method, file any amended
  Return, enter into any closing agreement, settle any Tax claim or
  assessment relating to Promedix, surrender any right to claim refund of
  Taxes, consent to any extension or waiver of the limitation period
  applicable to any Tax claim or assessment relating to Promedix, or take any
  other action or omit to take any action that would have the effect of
  increasing the Tax liability of Promedix or Chemdex;

     (s) take any action or fail to take any action that would cause there to
  be a Material Adverse Change with respect to Promedix;

     (t) enter into any agreement outside of the ordinary course of business
  in which the obligation of Promedix exceeds $50,000 or shall not terminate
  or be subject to termination for convenience within 180 days following
  execution;

     (u) enter into any agreement not in the ordinary course of business;

     (v) allow any intellectual property deadline, registrations or
  applications to lapse; or

     (w) take, or agree in writing or otherwise to take, any of the actions
  described in Sections (a) through (v) above, or any action which is
  reasonably likely to make any of Promedix's representations or warranties
  contained in this Agreement untrue or incorrect in any material respect on
  the date made (to the extent so limited) or as of the Effective Time.

   Section 5.3 Access to Information. Until the Closing, Promedix shall allow
Chemdex and its agents reasonable free access during normal business hours upon
reasonable notice to its files, books, records, and offices, including, without
limitation, any and all information relating to taxes, commitments, contracts,
leases, licenses, personnel, and personal property and financial condition and
such other information and data requested by Chemdex or its agents. Until the
Closing, Promedix shall cause its accountants to cooperate with Chemdex and its
agents in making available all financial information requested, including
without limitation the right to examine all working papers pertaining to all
financial statements prepared or audited by such accountants. No information or
knowledge obtained in any investigation pursuant to this Section shall affect
or be deemed to modify any representation or warranty contained in this
Agreement or its exhibits and schedules. All such access shall be subject to
the terms of the Confidentiality Agreement (as defined in Section 7.1).

   Section 5.4 Satisfaction of Conditions Precedent. Promedix will use its best
efforts to satisfy or cause to be satisfied all the conditions precedent which
are set forth in Sections 8.1 and 8.2, and Promedix will use its best efforts
to cause the transactions contemplated by this Agreement to be consummated,
and, without limiting the generality of the foregoing, to obtain all consents
and authorizations of third parties and to make all filings with, and give all
notices to, third parties which may be necessary or reasonably required on its
part in order to effect the transactions contemplated by this Agreement, and
any and all consents necessary with respect to those Material Contracts listed
on Schedule 5.4 of the Promedix Disclosure Schedule required to consummate the
Merger (collectively, such authorizations, notices and consents are referred to
herein as the "Material Consents").

   Section 5.5 Other Negotiations. Except with respect to Strategic Investors,
following the date hereof and until termination of this Agreement pursuant to
Section 9.1, Promedix will not (and it will not permit any of its officers,
directors, employees, agents and Affiliates on its behalf to) take any action
to solicit, initiate, seek, encourage or support any inquiry, proposal or offer
from, furnish any information to, or participate in any negotiations with, any
corporation, partnership, person or other entity or group (other than Chemdex)
regarding any acquisition of Promedix, any merger or consolidation with or
involving Promedix, or any acquisition of any material portion of the assets of
Promedix, or any acquisition of any capital stock of Promedix, or any material
license of Promedix Proprietary Rights (any of the foregoing being referred to
in this Agreement as an "Acquisition Transaction") or enter into an agreement
concerning any Acquisition Transaction with any party other than Chemdex. If
between the date of this Agreement and the termination of this Agreement
pursuant to Section 9.1, Promedix receives from a third party any offer or
indication of interest regarding any

                                      A-27
<PAGE>

Acquisition Transaction, or any request for information regarding any
Acquisition Transaction, Promedix shall (i) notify Chemdex immediately (orally
and in writing) of such offer, indication of interest or request, including the
identity of such party and the full terms of any proposal therein, and (ii)
notify such third party of Promedix's obligations under this Agreement (without
any reference to Chemdex). Notwithstanding the foregoing, nothing in this
Section 5.5 shall be construed to restrict the ability of the Promedix Board of
Directors to take such actions in connection with any proposed Acquisition
Transactions that such Board reasonably determines in good faith to be required
to permit it to discharge properly its fiduciary duties, provided that this
qualification shall in no way affect the obligations of Promedix and the
Promedix Board of Directors pursuant to Section 7.1.

                                   ARTICLE VI

               PRECLOSING AND OTHER COVENANTS OF CHEMDEX AND SUB

   Section 6.1 Advice of Changes. Chemdex and Sub will promptly advise Promedix
in writing of any event occurring subsequent to the date of this Agreement
which would render any representation or warranty of Chemdex or Sub contained
in this Agreement, if made on or as of the date of such event or the Closing
Date, untrue or inaccurate in any material respect.

   Section 6.2 Reservation of Chemdex Common Stock. Chemdex shall prior to the
Effective Time reserve for issuance, out of its authorized but unissued capital
stock, the maximum number of shares of Chemdex Common Stock as may be issuable
upon consummation of the Merger.

   Section 6.3 Satisfaction of Conditions Precedent. Chemdex and Sub will use
their best efforts to satisfy or cause to be satisfied all the conditions
precedent which are set forth in Sections 8.1 and 8.3, and Chemdex and Sub will
use their best efforts to cause the transactions contemplated by this Agreement
to be consummated, and, without limiting the generality of the foregoing, to
obtain all consents and authorizations of third parties and to make all filings
with, and give all notices to, third parties which may be necessary or
reasonably required on its part in order to effect the transactions
contemplated hereby.

   Section 6.4 Nasdaq National Market Listing. Chemdex shall prior to the
Effective Time cause the shares of Chemdex Common Stock issuable to the
stockholders of Promedix in the Merger to be authorized for listing on the
Nasdaq National Market.

   Section 6.5 Stock Options.

     (a) At the Effective Time, each outstanding Promedix Option under the
  Promedix Option Plan, whether vested or unvested, shall be assumed by
  Chemdex and deemed to constitute an option (an "Chemdex Option") to acquire
  the same number of shares of Chemdex Common Stock as the holder of such
  Promedix Option would have been entitled to receive pursuant to the Merger
  had such option been fully vested and had such holder exercised such option
  in full immediately prior to the Effective Time (rounded down to the
  nearest whole number), at a price per share (rounded up to the nearest
  whole cent) equal to (i) the aggregate exercise price for the shares of
  Promedix Common Stock otherwise purchasable pursuant to such Promedix
  Option divided by (ii) the number of full shares of Chemdex Common Stock
  deemed purchasable pursuant to such Chemdex Option in accordance with the
  foregoing; provided, however, that, in the case of any Promedix Option to
  which Section 422 of the Code applies ("Incentive Stock Options"), the
  option price, the number of shares purchasable pursuant to such option and
  the terms and conditions of exercise of such option shall be determined in
  order to comply with Section 424(a) of the Code. In connection with the
  assumption by Chemdex of the Promedix Options pursuant to this Section
  6.5(a), Promedix shall be deemed to have assigned to Chemdex, effective at
  the Effective Time, Promedix's right to repurchase unvested shares of
  Promedix Common Stock issuable upon the exercise of the Promedix Options or
  previously issued upon the exercise of options granted under the

                                      A-28
<PAGE>

  Promedix Option Plan, in accordance with the terms of the Promedix Option
  Plan and the related stock option agreements and stock purchase agreements
  entered into under the Promedix Option Plan.

     (b) As soon as practicable after the Effective Time, Chemdex shall
  deliver to the participants in the Promedix Option Plan appropriate notice
  setting forth such participants' rights pursuant thereto and the grants
  pursuant to the Promedix Option Plan shall continue in effect on the same
  terms and conditions (subject to the adjustments required by this Section
  6.5 after giving effect to the Merger). Chemdex shall comply with the terms
  of the Promedix Option Plan and the parties intend that, to the extent
  required by, and subject to the provisions of, such Promedix Option Plan
  and Sections 422 and 424(a) of the Code, that Promedix Options which
  qualified as Incentive Stock Options prior the Effective Time continue to
  qualify as Incentive Stock Options after the Effective Time, and this
  provision shall be interpreted consistent with that intent.

     (c) Chemdex shall take all corporate action necessary to reserve for
  issuance a sufficient number of shares of Chemdex Common Stock for delivery
  upon exercise of Promedix Options assumed in accordance with this Section
  6.5. As soon as practicable after the Effective Time and in any event no
  later than 10 business days after the Closing Date, Chemdex shall file a
  registration statement on Form S-8 (or any successor or other appropriate
  forms) under the Securities Act or another appropriate form with respect to
  the shares of Chemdex Common Stock subject to such options and shall use
  its best efforts to maintain the effectiveness of such registration
  statement or registration statements (and maintain the current status of
  the prospectus or prospectuses contained therein) for so long as such
  options remain outstanding.

     (d) Each Promedix Warrant, to the extent outstanding at the Effective
  Time, whether or not exercisable and whether or not vested at the Effective
  Time, shall remain outstanding at the Effective Time. At the Effective
  Time, Promedix Warrants shall, by virtue of the Merger and without any
  further action on the part of Promedix or the holder of any of Promedix
  Warrants (unless further action may be required by the terms of any of
  Promedix Warrants), be assumed by Chemdex pursuant to such documentation as
  is reasonably acceptable to Promedix and each Promedix Warrant assumed by
  Chemdex shall be exercisable upon the same terms and conditions as under
  the applicable warrant agreements with respect to such Promedix Warrants,
  except that (A) each such Promedix Warrant shall be exercisable for that
  whole number of shares of Chemdex Common Stock (rounded down to the nearest
  whole share) into which the number of shares of Promedix Common Stock
  subject to such Promedix Warrant would be converted under Section 2.1(c),
  and (B) the exercise price per share of Chemdex Common Stock shall be an
  amount equal to the exercise price per share of Promedix Common Stock
  subject to such Promedix Warrant in effect immediately prior to the
  Effective Time divided by the applicable Exchange Ratio (the exercise price
  per share, so determined, being rounded to the nearest full cent). From and
  after the Effective Time, all references to Promedix in the warrant
  agreements underlying Promedix Warrants shall be deemed to refer to
  Chemdex. Chemdex further agrees that, notwithstanding any other term of
  this Section 6.5(d) to the contrary, if required under the terms of
  Promedix Warrants or if otherwise appropriate under the terms of Promedix
  Warrants, it will execute a supplemental agreement with the holders of
  Promedix Warrants to effectuate the foregoing. No payment shall be made for
  fractional shares. Chemdex shall (i) on or prior to the Effective Time,
  reserve for issuance the number of shares of Chemdex Common Stock that will
  become subject to warrants to purchase Chemdex Common Stock ("Chemdex
  Warrants") pursuant to this Section 6.5(d), (ii) from and after the
  Effective Time, upon exercise of the Chemdex Warrants in accordance with
  the terms thereof, make available for issuance all shares of Chemdex Common
  Stock covered thereby and (iii) as promptly as practicable following the
  Effective Time, issue to each holder of an outstanding Promedix Warrant a
  document evidencing the foregoing assumption by Chemdex.

   Section 6.6 Certain Employee Benefit Matters. From and after the Effective
Time, employees of Promedix at the Effective Time (each, an "Promedix
Employee") will be provided with employee benefits by the Surviving Corporation
or Chemdex which in the aggregate are no less favorable to such employees than
those provided from time to time by Chemdex to its similarly situated
employees. If any employee of Promedix

                                      A-29
<PAGE>

becomes a participant in any employee benefit plan, program, policy or
arrangement of Chemdex, such employee shall be given credit for all service
prior to the Effective Time with Promedix to the extent permissible under such
plan, program, policy or arrangement. It is the present intention of Chemdex
that no Promedix Employee as of the time of Closing shall be required to
relocate from Salt Lake City, Utah in order to continue their employment with
Promedix and Chemdex following the Closing.

   Section 6.7 Contingent Financing. Within 15 days after the execution of this
Agreement, Chemdex shall provide Promedix a line of credit of $10,000,000 that
is secured by Promedix's assets, or such larger amount as the parties agree
pursuant to a secured loan agreement in the form attached hereto as Exhibit G
(the "Loan Agreement"). Chemdex agrees to enter into a subordination agreement
with Promedix's and its Subsidiaries existing secured creditors upon terms and
conditions reasonably satisfactory to Chemdex and such secured creditors, and
to the extent necessary, to modify the Loan Agreement in accordance with such
subordination agreement.

   Section 6.8 D&O Indemnification. From and after the Effective Time, Chemdex
will cause the Surviving Corporation to fulfill and honor in all respects the
obligations of Promedix pursuant to any indemnification agreements between
Promedix and its directors and officers as of the date of this Agreement (the
"Indemnified Parties"). The Certificate of Incorporation and Bylaws of the
Surviving Corporation will contain provisions with respect to exculpation and
indemnification that are at least as favorable to the Indemnified Parties as
those contained in the Certificate of Incorporation and Bylaws of Promedix as
in effect on the date hereof, which provisions will not be amended, repealed or
otherwise modified for a period of six years from the Effective Time in any
manner that would adversely affect the rights thereunder of individuals who
were directors, officer, employees or agents of Promedix, unless such
modification is required by law.

   Section 6.9 Salt Lake City Presence. Chemdex will maintain a significant
presence in Salt Lake City for at least two (2) years following the Closing
Date.

   Section 6.10 Operation of Business. During the period from the date of this
Agreement and continuing until the earlier of the termination of the Agreement
or the Effective Time, except as expressly contemplated by this Agreement or
the Chemdex Disclosure Schedule, Chemdex shall not, without the prior written
consent of Promedix:

     (a) declare or pay any dividends on or make or agree to make any other
  distributions (whether in cash, stock or property) in respect of any of its
  capital stock; or

     (b) amend its Certificate of Incorporation.

   Section 6.11 Other Negotiations. Following the date hereof and until
termination of this Agreement pursuant to Section 9.1, Chemdex will not (and it
will not permit any of its officers, directors, employees, agents and
Affiliates on its behalf to) take any action to solicit, initiate, seek,
encourage or support any inquiry, proposal or offer from, furnish any
information to, or participate in any negotiations with, any corporation,
partnership, person or other entity or group (other than Promedix) regarding
any acquisition of a direct e-commerce competitor of Promedix (a "Promedix
Competitor"), any merger or consolidation with or involving a Promedix
Competitor, or any acquisition of any material portion of the assets of a
Promedix Competitor, or any acquisition of any capital stock of a Promedix
Competitor, or any material license of a Promedix Competitor's Proprietary
Rights (any of the foregoing being referred to in this Agreement as a "Chemdex
Acquisition Transaction") or enter into an agreement concerning any Chemdex
Acquisition Transaction with any party other than Promedix. If between the date
of this Agreement and the termination of this Agreement pursuant to Section
9.1, Chemdex receives from a third party any offer or indication of interest
regarding any Chemdex Acquisition Transaction, or any request for information
regarding any Chemdex Acquisition Transaction, Chemdex shall (i) notify
Promedix immediately (orally and in writing) of such offer, indication of
interest or request, including the identity of such party and the full terms of
any proposal therein, and (ii) notify such third party of Chemdex's obligations
under this Agreement (without any reference to Promedix). Notwithstanding the
foregoing, nothing in this Section 6.11 shall be construed to restrict the
ability

                                      A-30
<PAGE>

of the Chemdex Board of Directors to take such actions in connection with any
proposed Chemdex Acquisition Transactions that such Board reasonably determines
in good faith to be required to permit it to discharge properly its fiduciary
duties, provided that this qualification shall in no way affect the obligations
of Chemdex and the Chemdex Board of Directors pursuant to Section 7.1.

                                  ARTICLE VII

                      PRECLOSING COVENANTS OF PROMEDIX AND

                          CHEMDEX AND OTHER AGREEMENTS

   During the period from the date of this Agreement until the Effective Time,
the parties covenant and agree as follows:

   Section 7.1 Proxy Statement/Prospectus.

     (a) As soon as practicable after the execution of this Agreement,
  Promedix and Chemdex shall mutually cooperate in jointly preparing and
  filing with the Commission the Proxy Statement/Prospectus. The Proxy
  Statement/Prospectus shall constitute a disclosure document for the offer
  and issuance of the shares of Chemdex Common Stock to be received by the
  holders of the capital stock of Promedix in the Merger and for the other
  transactions contemplated by this Agreement. As promptly as practicable
  after comments, if any, are received from the Commission with respect to
  such Proxy Statement/Prospectus and after the furnishing by Promedix and
  Chemdex of all information required to be contained therein, Promedix and
  Chemdex shall prepare and file with the Commission the Registration
  Statement, in which the Proxy Statement/Prospectus shall be included, in
  connection with the registration under the Securities Act of the shares of
  Chemdex Common Stock to be issued to the holders of the capital stock of
  Promedix pursuant to the Merger. Chemdex and Promedix shall use all
  reasonable efforts to have or cause the Registration Statement to become
  effective as promptly as practicable, and shall take all or any action
  required under any applicable federal or state securities laws in
  connection with the issuance of Chemdex Common Stock pursuant to the
  Merger. As promptly as practicable after the Registration Statement shall
  have become effective, Chemdex and Promedix shall each mail or cause to be
  mailed the Proxy Statement/Prospectus to their respective stockholders.

     (b) Chemdex and Promedix shall each use its best efforts to cause the
  Proxy Statement/Prospectus to comply with applicable federal and state
  securities laws requirements. Each of Chemdex and Promedix agrees to
  provide promptly to the other such information concerning its business and
  financial statements and affairs as, in the reasonable judgment of the
  providing party or its counsel, may be required or appropriate for
  inclusion in the Proxy Statement/Prospectus, or in any amendments or
  supplements thereto, and to cause its counsel and auditors to cooperate
  with the other's counsel and auditors in the preparation of the Proxy
  Statement/Prospectus. The information supplied by each of Chemdex and
  Promedix for inclusion in the Proxy Statement/Prospectus and Registration
  Statement shall not, at (i) the time the Registration Statement is declared
  effective, (ii) the time the Proxy Statement/Prospectus is first mailed to
  the holders of capital stock of Promedix, (iii) the time of the Promedix
  Stockholders' Meeting, (iv) the time of the Chemdex Stockholders' meeting,
  and (v) the Effective Time, contain any untrue statement of a material fact
  or omit to state any material fact required to be stated therein or
  necessary in order to make the statements therein not misleading. Promedix
  will promptly advise Chemdex, and Chemdex will promptly advise Promedix, in
  writing if at any time prior to the Effective Time either Promedix or
  Chemdex shall obtain knowledge of any facts that might make it necessary or
  appropriate to amend or supplement the Proxy Statement/Prospectus in order
  to make the statements contained or incorporated by reference therein not
  misleading or to comply with applicable law.

     (c) The Proxy Statement/Prospectus shall contain the unanimous
  recommendation of the Board of Directors of Promedix that the Promedix
  stockholders approve the Merger and this Agreement and the

                                      A-31
<PAGE>

  conclusion of the Board of Directors that the terms and conditions of the
  Merger are fair and reasonable to the stockholders of Promedix. The Proxy
  Statement/Prospectus shall contain the unanimous recommendation of the
  Board of Directors of Chemdex that the Chemdex stockholders approve the
  issuance of Common Stock to the Promedix stockholders and this Agreement
  and the conclusion of the Board of Directors that the terms and conditions
  of the Merger are fair and reasonable to the stockholders of Chemdex.
  Anything to the contrary contained herein notwithstanding, Promedix shall
  not include in the Proxy Statement/Prospectus any information with respect
  to Chemdex or its affiliates or associates, the form and content of which
  information shall not have been approved by Chemdex prior to such
  inclusion. Anything to the contrary contained herein notwithstanding,
  Chemdex shall not include in the Proxy Statement/Prospectus any information
  with respect to Promedix or its affiliates or associates, the form and
  content of which information shall not have been approved by Promedix prior
  to such inclusion.

   Section 7.2 Stockholder Meetings.

     (a) Promptly after the date hereof, Promedix will take all action
  necessary in accordance with the Delaware Law and its Certificate of
  Incorporation and Bylaws to convene the Promedix Stockholders' Meeting to
  be held as promptly as practicable, and in any event (to the extent
  permissible under applicable law) within 45 days after the declaration of
  effectiveness of the Registration Statement, for the purpose of voting upon
  this Agreement and the Merger or the issuance of shares of Chemdex Common
  Stock pursuant to the Merger, respectively. Promedix will use its
  commercially reasonable efforts to solicit from its stockholders proxies in
  favor of the adoption and approval of this Agreement and the approval of
  the Merger and will take all other action necessary or advisable to secure
  the vote or consent of its stockholders required by the rules of the NASD
  or Delaware Law to obtain such approvals. Notwithstanding anything to the
  contrary contained in this Agreement, Promedix may adjourn or postpone
  Promedix Stockholders' Meeting to the extent necessary to ensure that any
  necessary supplement or amendment to the Proxy Statement/Prospectus is
  provided to Promedix's stockholders in advance of a vote on the Merger and
  this Agreement or, if as of the time for which Promedix Stockholders'
  Meeting is originally scheduled (as set forth in the Proxy
  Statement/Prospectus) there are insufficient shares of Promedix capital
  stock represented (either in person or by proxy) to constitute a quorum
  necessary to conduct the business of the Promedix's Stockholders' Meeting.
  Promedix shall ensure that the Promedix Stockholders' Meeting is called,
  noticed, convened, held and conducted and that all proxies solicited by the
  Promedix in connection with the Promedix Stockholders' Meeting are
  solicited, in compliance with the Delaware Law, its Certificate of
  Incorporation and Bylaws, the rules of the NASD and all other applicable
  legal requirements. Promedix's obligation to call, give notice of, convene
  and hold the Promedix Stockholders' Meeting in accordance with this Section
  7.2(a) shall not be limited or otherwise affected by the commencement,
  disclosure, announcement or submission to Promedix of any proposed Promedix
  Acquisition Transaction, or by any withdrawal, amendment or modification of
  the recommendation of the Board of Directors of Promedix with respect to
  the Merger.

     (b) Promptly after the date hereof, Chemdex will take all action
  necessary in accordance with the Delaware Law and its Certificate of
  Incorporation and Bylaws to convene the Chemdex Stockholders' Meeting to be
  held as promptly as practicable, and in any event (to the extent
  permissible under applicable law) within 45 days after the declaration of
  effectiveness of the Registration Statement, for the purpose of voting upon
  this Agreement and the Merger or the issuance of shares of Chemdex Common
  Stock pursuant to the Merger, respectively. Chemdex will use its
  commercially reasonable efforts to solicit from its stockholders proxies in
  favor of the adoption and approval of this Agreement and the approval of
  the Merger and will take all other action necessary or advisable to secure
  the vote or consent of its stockholders required by the rules of the NASD
  or Delaware Law to obtain such approvals. Notwithstanding anything to the
  contrary contained in this Agreement, Chemdex may adjourn or postpone
  Chemdex Stockholders' Meeting to the extent necessary to ensure that any
  necessary supplement or amendment to the Proxy Statement/Prospectus is
  provided to Chemdex's stockholders in advance of a vote on the Merger and
  this Agreement or, if as of the time for which Chemdex Stockholders'
  Meeting is originally scheduled (as set forth in the Proxy
  Statement/Prospectus) there are insufficient shares of

                                      A-32
<PAGE>

  Chemdex capital stock represented (either in person or by proxy) to
  constitute a quorum necessary to conduct the business of the Chemdex's
  Stockholders' Meeting. Chemdex shall ensure that the Chemdex Stockholders'
  Meeting is called, noticed, convened, held and conducted that all proxies
  solicited by the Chemdex in connection with the Chemdex Stockholders'
  Meeting are solicited, in compliance with the Delaware Law, its Certificate
  of Incorporation and Bylaws, the rules of the NASD and all other applicable
  legal requirements. Chemdex's obligation to call, give notice of, convene
  and hold the Chemdex Stockholders' Meeting in accordance with this Section
  7.2(b) shall not be limited or otherwise affected by the commencement,
  disclosure, announcement or submission to Chemdex of any proposed Chemdex
  Acquisition Transaction, or by any withdrawal, amendment or modification of
  the recommendation of the Board of Directors of Chemdex with respect to the
  Merger.

   Section 7.3 Confidentiality. Each party acknowledges that Chemdex and
Promedix have executed a Mutual Non-Disclosure Agreement in August 1999 (the
"Confidentiality Agreement"), which agreement shall continue in full force and
effect in accordance with its terms.

   Section 7.3 No Public Announcement. Each of Chemdex and Promedix agrees that
neither it nor any of their respective representatives, officers, directors,
agents, stockholder or affiliates shall make any public announcement with
respect to this Agreement or the transactions contemplated hereby, or disclose
the terms or existence of this Agreement to any third party prior to the public
announcement of the transactions contemplated hereby. All public announcements
with respect to this Agreement or the transactions contemplated hereby will be
made upon the mutual agreement of the parties and only after each party has had
the opportunity to review and comment on the proposed public announcement.

   Section 7.4 Regulatory Filings; Consents; Reasonable Efforts. Subject to the
terms and conditions of this Agreement, Promedix and Chemdex shall use their
respective reasonable good faith efforts to (i) make all necessary filings with
respect to the Merger and this Agreement under the Exchange Act and applicable
blue sky or similar securities laws and obtain required approvals and
clearances with respect thereto and supply all additional information requested
in connection therewith; (ii) make merger notification or other appropriate
filings with federal, state or local governmental bodies or applicable foreign
governmental agencies and obtain required approvals and clearances with respect
thereto and supply all additional information requested in connection
therewith; (iii) obtain all consents, waivers, approvals, authorizations and
orders required in connection with the authorization, execution and delivery of
this Agreement and the consummation of the Merger; and (iv) take, or cause to
be taken, all appropriate action, and do, or cause to be done, all things
necessary, proper or advisable to consummate and make effective the
transactions contemplated by this Agreement as promptly as practicable.

   Section 7.5 Further Assurances. Prior to and following the Closing, each
party agrees to cooperate fully with the other parties and to execute such
further instruments, documents and agreements and to give such further written
assurances, as may be reasonably requested by any other party to better
evidence and reflect the transactions described herein and contemplated hereby
and to carry into effect the intents and purposes of this Agreement.

   Section 7.6 Escrow Agreement. On or before the Effective Time, Chemdex
shall, and the parties hereto shall exercise their reasonable good faith
efforts to cause the Escrow Agent (as defined in Section 10.2) and the
Stockholders' Agents (as defined in Section 10.8), to enter into an Escrow
Agreement in substantially the form attached hereto as Exhibit E.

   Section 7.7 FIRPTA. Promedix shall, prior to the Closing Date, provide
Chemdex with a properly executed Foreign Investment and Real Property Tax Act
of 1980 ("FIRPTA") FIRPTA Notification Letter which states that shares of
capital stock of Promedix do not constitute "United States real property
interests" under Section 897(c) of the Code, for purposes of satisfying
Chemdex's obligations under Treasury Regulation Section 1.1445-2(c)(3). In
addition, simultaneously with delivery of such FIRPTA Notification Letter,
Promedix shall provide to Chemdex, as agent for Promedix, a form of notice to
the Internal Revenue Service in

                                      A-33
<PAGE>

accordance with the requirements of Treasury Regulation Section 1.897-2(h)(2),
along with written authorization for Chemdex to deliver such notice form to the
Internal Revenue Service on behalf of Promedix upon the Closing of the Merger.

   Section 7.8 Other Filings. As promptly as practicable after the date of this
Agreement, Promedix and Chemdex will prepare and file any other filings
required under the Exchange Act, the Securities Act or any other Federal,
foreign or state securities or blue sky laws relating to the Merger and the
transactions contemplated by this Agreement (the "Other Filings"). The Other
Filings will comply in all material respects with all applicable requirements
of law and the rules and regulations promulgated thereunder. Whenever any event
occurs which is required to be set forth in an amendment or supplement to the
Other Filings, Promedix or Chemdex, as the case may be, will promptly inform
the other of such occurrence and cooperate in making any appropriate amendment
or supplement, and/or mailing to stockholders of Promedix, such amendment or
supplement.

   Section 7.10 Tax Matters.

     (a) Neither Chemdex nor Sub (nor any of their respective affliliates)
  (i) has through the date of this Agreement taken or agreed to take any
  action that could reasonably be expected to prevent the Merger to qualify
  as a tax-free reorganization within the meaning of Sections 368(a)(1)(A)
  and 368(a)(2)(E) of the Code, and (b) shall take any action after the date
  hereof that could reasonably be expected to cause the Merger not to qualify
  as a reorganization within the meaning of Sections 368(a)(1)(A) and
  368(a)(2)(E) of the Code. Each of Chemdex and Promedix shall not take a
  position on any Tax Return inconsistent with such treatment. Chemdex and
  Promedix each shall give the other prompt notice of any challenges or
  investigations undertaken by any Tax agency in connection with such
  reporting and shall keep the other fully informed of all aspects of any
  such ongoing challenge or investigation.

     (b) Each of Promedix and Chemdex shall cooperate with each other in
  obtaining the opinion of Orrick, Herrington & Sutcliffe LLP, to be rendered
  to Promedix, and Venture Law Group, to be rendered to Chemdex, each dated
  as of the Closing Date, to the effect that the Merger will constitute a
  "reorganization" within the meaning of Section 368(a) of the Code. In
  connection therewith, if counsel shall so request, each of Chemdex, Sub and
  Promedix shall deliver to Orrick, Herrington & Sutcliffe LLP and Venture
  Law Group customary representation letters (such representation letters
  collectively referred to as the "Tax Certificates"), to the extent that
  they are able to make such customary representations.

   Section 7.11 Transition Planning. Promedix and Chemdex shall work together
to coordinate all aspects of transition planning and implementation relating to
the Merger and the other transactions contemplated hereby. During the period
between the date hereof and the Effective Time, Promedix and Chemdex shall
jointly examine various alternatives regarding the manner in which to best
organize and manage the business of Promedix and Chemdex after the Effective
Time.

                                  ARTICLE VIII

                              CONDITIONS TO MERGER

   Section 8.1 Conditions to Each Party's Obligation to Effect the Merger. The
respective obligations of each party to this Agreement to effect the Merger
shall be subject to the satisfaction prior to the Closing Date of the following
conditions:

     (a) Stockholder Approval. The stockholders of Promedix entitled to vote
  on or consent to this Agreement and the Merger in accordance with Delaware
  Law and Promedix's Certificate of Incorporation, shall have approved this
  Agreement and the Merger. The stockholders of Chemdex entitled to vote on
  or consent to this Agreement and the Merger in accordance with the Delaware
  Law and Chemdex's Certificate of Incorporation shall have approved this
  Agreement and the issuance of the shares Chemdex Common Stock in connection
  with the Merger.

                                      A-34
<PAGE>

     (b) Approvals. Other than the filing provided for by Section 1.2, all
  authorizations, consents, orders or approvals of, or declarations or
  filings with, or expirations of waiting periods imposed by, any
  Governmental Entity shall have been filed, occurred or been obtained.

     (c) No Injunctions or Restraints; Illegality. No temporary restraining
  order, preliminary or permanent injunction or other order issued by any
  court of competent jurisdiction or other legal or regulatory restraint or
  prohibition preventing the consummation of the Merger or limiting or
  restricting the conduct or operation of the business of Promedix by Chemdex
  after the Merger shall have been issued, nor shall any proceeding brought
  by a domestic administrative agency or commission or other domestic
  Governmental Entity or other third party, seeking any of the foregoing be
  pending; nor shall there be any action taken, or any statute, rule,
  regulation or order enacted, entered, enforced or deemed applicable to the
  Merger which makes the consummation of the Merger illegal.

     (d) Nasdaq. The shares of Chemdex Common Stock to be issued in the
  Merger shall have been approved for quotation on the Nasdaq Stock Market.

     (e) Effectiveness of Registration Statement. The Registration Statement
  shall have become effective in accordance with the provisions of the
  Securities Act, and no stop order shall have been issued by the Commission
  with respect to the Registration Statement.

     (f) Tax Opinion. Promedix shall have received the opinion dated the
  Closing Date of Orrick, Herrington & Sutcliffe LLP, and Chemdex shall have
  received the opinion dated the Closing Date of Venture Law Group, each to
  the effect that the Merger, for federal income tax purposes, will
  constitute a "reorganization" within the meaning of Section 368(a) of the
  Code. In rendering such opinion, counsel shall be entitled to rely upon,
  among other things, reasonable assumptions as well as representations of
  Chemdex, Sub and Promedix.

     (g) Act. The waiting period applicable to the consummation of the Merger
  under the Hart-Scott-Rodino Antitrust Improvement Act of 1976, as amended,
  shall have expired or been terminated.

     (h) Blue Sky Laws. Chemdex shall have received all state securities or
  "Blue Sky" permits and other authorizations necessary to issue shares of
  Chemdex Common Stock pursuant to the Merger.

   Section 8.2 Additional Conditions to Obligations of Chemdex and Sub. The
obligations of Chemdex and Sub to effect the Merger are subject to the
satisfaction of each of the following conditions, any of which may be waived in
writing exclusively by Chemdex and Sub:

     (a) Representations and Warranties. The representations and warranties
  of Promedix set forth in this Agreement shall be true and correct in all
  material respects as of the date of this Agreement and (except to the
  extent such representations and warranties speak as of an earlier date) as
  of the Closing Date as though made on and as of the Closing Date, except
  for changes contemplated by this Agreement; and Chemdex shall have received
  a certificate signed on behalf of Promedix by the chief executive officer
  and the chief financial officer of Promedix to such effect.

     (b) Performance of Obligations of Promedix. Promedix shall have
  performed in all material respects all obligations required to be performed
  by it under this Agreement at or prior to the Closing Date; and Chemdex
  shall have received a certificate signed on behalf of Promedix by the chief
  executive officer of Promedix to such effect.

     (c) Dissenting Stockholders. Holders of Promedix's issued and
  outstanding capital stock as of the Closing representing no more than 5% of
  the outstanding shares of Promedix capital stock shall have elected to, or
  continue to have contingent rights to, exercise appraisal rights under
  Delaware Law as to such shares.

     (d) Escrow Agreement. The Escrow Agent and Stockholders' Agents shall
  have executed and delivered to Chemdex the Escrow Agreement and such
  agreement shall remain in full force and effect.


                                      A-35
<PAGE>

     (e) Ancillary Agreements. Each of the Voting Agreements, Employment
  Agreements, Affiliates Agreement, and the Stock Restriction Agreements
  executed and delivered concurrently with the execution of this Agreement
  shall remain in full force and effect.

     (f) Opinion of Promedix's Counsel. Chemdex shall have received an
  opinion dated the Closing Date of Orrick, Herrington & Sutcliffe LLP,
  counsel to Promedix, as to the matters set forth on Exhibit H.

     (g) Approvals. All Material Consents shall have been obtained.

     (h) Board Resignations. Promedix shall have received written letters of
  resignation from the Promedix Board of Directors from each of the current
  members of such Board, in each case effective at the Effective Time.

     (i) Fulfillment Business Sale. The Fulfillment Business Sale shall have
  closed prior to the Closing.

     (j) Conversion of Convertible Debt. The Convertible Debt shall have
  converted into Promedix capital stock or have been repaid prior to the
  Closing.

   Section 8.3  Additional Conditions to Obligations of Promedix. The
obligation of Promedix to effect the Merger is subject to the satisfaction of
each of the following conditions, any of which may be waived, in writing,
exclusively by Promedix:

     (a) Representations and Warranties. The representations and warranties
  of Chemdex and Sub set forth in this Agreement shall be true and correct in
  all material respects as of the date of this Agreement and (except to the
  extent such representations speak as of an earlier date) as of the Closing
  Date as though made on and as of the Closing Date, and Promedix shall have
  received a certificate signed on behalf of Chemdex by the chief financial
  officer of Chemdex to such effect.

     (b) Performance of Obligations of Chemdex and Sub. Chemdex and Sub shall
  have performed in all material respects all obligations required to be
  performed by them under this Agreement at or prior to the Closing Date; and
  Promedix shall have received a certificate signed on behalf of Chemdex by
  the chief financial officer of Chemdex to such effect.

     (c) Board Matters. Effective upon the Closing Date, Skip Klintworth and
  one outside director to be mutually agreed upon shall become members of
  Chemdex's Board of Directors.

     (d) Opinion of Chemdex's Counsel. Promedix shall have received an
  opinion dated the Closing Date of Venture Law Group, counsel to Chemdex, as
  to the matters set forth on Exhibit H.

                                  ARTICLE IX

                           TERMINATION AND AMENDMENT

   Section 9.1 Termination. This Agreement may be terminated at any time prior
to the Effective Time:

     (a) by mutual written consent of Chemdex and Promedix;

     (b) by either Chemdex or Promedix, by giving written notice to the other
  party, if a court of competent jurisdiction or other Governmental Entity
  shall have issued a nonappealable final order, decree or ruling or taken
  any other action, in each case having the effect of permanently
  restraining, enjoining or otherwise prohibiting the Merger, except, if such
  party relying on such order, decree or ruling or other action shall not
  have complied with its respective obligations under Sections 5.5 or 6.3 of
  this Agreement, as the case may be;

     (c) by Chemdex or Promedix, by giving written notice to the other party,
  if the other party is in material breach of any representation, warranty,
  or covenant of such other party contained in this Agreement, which breach
  shall not have been cured, if subject to cure, within 10 business days
  following receipt by the breaching party of written notice of such breach
  by the other party;

                                     A-36
<PAGE>

     (d) by Chemdex, by giving written notice to Promedix, if the Closing
  shall not have occurred on or before February 29, 2000 by reason of the
  failure of any condition precedent under Section 8.1 or 8.2 (unless the
  failure results primarily from a breach by Chemdex of any representation,
  warranty, or covenant of Chemdex contained in this Agreement or Chemdex's
  failure to fulfill a condition precedent to closing or other default);

     (e) by Promedix, by giving written notice to Chemdex, if the Closing
  shall not have occurred on or before February 29, 2000 by reason of the
  failure of any condition precedent under Section 8.1 or 8.3 (unless the
  failure results primarily from a breach by Promedix of any representation,
  warranty, or covenant of Promedix contained in this Agreement or Promedix's
  failure to fulfill a condition precedent to closing or other default);

     (f) by Chemdex, by giving written notice to Promedix, if (i) the Board
  of Directors of Promedix shall have recommended an alternative transaction
  in which a third party (other than a Strategic Investor) would receive from
  Promedix 20% or more of the outstanding capital stock or assets of
  Promedix, (ii) the Board of Directors of Promedix shall have recommended
  that stockholders of Promedix tender their shares in a tender offer from a
  third party for more than 20% of the Promedix outstanding capital stock, or
  (iii) the required approvals of the stockholders of Promedix contemplated
  by this Agreement shall not have been obtained by reason of the failure to
  obtain the required consents or votes upon a vote taken by written consent
  or at a meeting of stockholders, duly convened therefor or at any
  adjournment thereof; or

     (g) by Promedix, by giving written notice to Chemdex, if (i) the Board
  of Directors of Chemdex shall have recommended an alternative transaction
  in which a third party would receive from Chemdex 20% or more of the
  outstanding capital stock or assets of Chemdex, (ii) the Board of Directors
  of Chemdex shall have recommended that stockholders of Chemdex tender their
  shares in a tender offer from a third party for more than 20% of the
  Chemdex outstanding capital stock, or (iii) the required approvals of the
  stockholders of Chemdex contemplated by this Agreement shall not have been
  obtained by reason of the failure to obtain the required consents or votes
  upon a vote taken by written consent or at a meeting of stockholders, duly
  convened therefor or at any adjournment thereof.

   Section 9.2 Effect of Termination. In the event of termination of this
Agreement as provided in Section  9.1, this Agreement shall immediately become
void and there shall be no liability or obligation on the part of Chemdex,
Promedix, Sub or their respective officers, directors, stockholders or
Affiliates, except as set forth in Section 9.3 and further except to the extent
that such termination results from the willful breach by any such party of any
of its representations, warranties or covenants set forth in this Agreement.

   Section 9.3 Fees and Expenses.

     (a) Except as set forth in this Section 9.3, all fees and expenses
  incurred in connection with this Agreement and the transactions
  contemplated hereby shall be paid by the party incurring such expenses,
  whether or not the Merger is consummated. Promedix has submitted a budget
  to Chemdex for completion of the Merger. Promedix shall use its best
  efforts to consummate the Merger within such budget and shall not enter
  into any agreement inconsistent with such budget.

     (b) If the Merger is consummated, all expenses incurred by Promedix
  shall be assumed by Chemdex.

     (c) In the event that this Agreement shall be terminated by Promedix (i)
  pursuant to Section 9.1(c) and the breach or series of breaches giving rise
  to such termination right shall have been intentional or willful on the
  part of Chemdex, or (ii) pursuant to Section 9.1(g), then within two
  business days of such termination Chemdex shall pay Promedix by wire
  transfer a fee equal to $10,000,000.

     (d) In the event that this Agreement shall be terminated by Chemdex (i)
  pursuant to Section 9.1(c) and the breach or series of breaches giving rise
  to such termination right shall have been intentional or willful on the
  part of Promedix, or (ii) pursuant to Section 9.1(f), then within two
  business days of such termination Promedix shall pay Chemdex by wire
  transfer a fee equal to $10,000,000.

                                      A-37
<PAGE>

     (e) Payment of the fee by either party as set forth in Section 9.3(c) or
  (d) above shall not be in lieu of, but shall be in addition to, any other
  legal or equitable remedies available to the other party for breach of this
  Agreement.

     (f) Each party agrees that if it fails to pay the entire fee within two
  business days of termination, then any unpaid amounts shall accrue interest
  at a rate of 9% per annum until paid.

                                   ARTICLE X

                           ESCROW AND INDEMNIFICATION

   Section 10.1 Indemnification.  From and after the Effective Time and subject
to the limitations contained in Section 10.2, the Former Promedix Stockholders
will, severally and pro rata, in accordance with their Pro Rata Portion,
indemnify and hold Chemdex harmless against any loss, expense, liability or
other damage, including attorneys' fees, to the extent of the amount of such
loss, expense, liability or other damage (collectively "Damages") that Chemdex
has incurred by reason of the breach by Promedix of any representation,
warranty, covenant or agreement of Promedix contained in this Agreement that
occurs or becomes known to Chemdex during the Escrow Period (as defined in
Section 10.3 below) in excess of $150,000. Chemdex, Promedix and Sub
acknowledge and agree, and the Former Promedix Stockholders, by their approval
of this Agreement and their execution of the Voting Agreements, agree that
notwithstanding anything to the contrary contained in this Agreement or any
other Transaction Document, such indemnification under this Article X shall be
the sole and exclusive remedy for any such claim of breach by Promedix, except
for Damages based upon a claim of fraud.

   Section 10.2 Escrow Fund. As security and the sole and exclusive recourse
for the indemnities in Section 10.1, as soon as practicable after the Effective
Time, the Escrow Shares shall be deposited with U.S. Bank Trust, National
Association (or such other institution selected by Chemdex with the reasonable
consent of Promedix) as escrow agent (the "Escrow Agent"), such deposit to
constitute the Escrow Fund (the "Escrow Fund") and to be governed by the terms
set forth in this Article X and in the Escrow Agreement. Notwithstanding the
foregoing or anything to the contrary contained in this Agreement or in any
Transaction Document, the indemnification obligations of the Former Promedix
Stockholders pursuant to this Article X or otherwise shall be limited to the
amount and assets deposited and present in the Escrow Fund and Chemdex shall
not be entitled to pursue any claims for indemnification under this Article X
or otherwise against the Former Promedix Stockholders directly or personally,
and the sole recourse of Chemdex shall be to make claims against the Escrow
Fund in accordance with the terms of the Escrow Agreement.

   Section 10.3 Escrow Periods. The Escrow Fund shall terminate upon the first
anniversary date of the Closing Date (the period from the Closing Date to such
date referred to as the "Escrow Period"), provided, however, that the number of
Escrow Shares, which, in the reasonable judgment of Chemdex, subject to the
objection of the Stockholders' Agents and the subsequent resolution of the
matter in the manner provided in Section 10.7, are necessary to satisfy any
unsatisfied claims specified in any Officer's Certificate theretofore delivered
to the Escrow Agent and the Stockholders' Agents prior to termination of the
Escrow Period with respect to Damages incurred or litigation pending prior to
expiration of the Escrow Period, shall remain in the Escrow Fund until such
claims have been finally resolved.

   Section 10.4 Claims Upon Escrow Fund. Upon receipt by the Escrow Agent on or
before the last day of the Escrow Period of a certificate signed by any
appropriately authorized officer of Chemdex (an "Officer's Certificate"):

     (i) Stating the aggregate amount of Chemdex's Damages or an estimate
  thereof, in each case to the extent known or determinable at such time; and


                                      A-38
<PAGE>

     (ii) Specifying in reasonable detail the individual items of such
  Damages included in the amount so stated, the date each such item was paid
  or properly accrued or arose, and the nature of the misrepresentation,
  breach or claim to which such item is related, the Escrow Agent shall,
  subject to the provisions of Sections 10.3 and 10.7 hereof and of the
  Escrow Agreement, deliver to Chemdex out of the Escrow Fund, as promptly as
  practicable, Escrow Shares having a value equal to such Damages all in
  accordance with the Escrow Agreement and Section 10.5 below. Amounts paid
  or distributed from the Escrow Fund shall be paid or distributed pro rata
  among the Holders (as defined in the Escrow Agreement) based upon their
  respective percentage interests therein at the time.

   Section 10.5 Valuation. For the purpose of compensating Chemdex for its
Damages pursuant to this Agreement, the value per share of the Escrow Shares
which shall be released to Chemdex in respect of a claim for Damages shall be
the Average Stock Price (as appropriately adjusted for stock splits,
recapitalizations and the like).

   Section 10.6 Objections to Claims. At the time of delivery of any Officer's
Certificate to the Escrow Agent, a duplicate copy of such Officer's Certificate
shall be delivered to the Stockholders' Agents (as defined in Section 10.8
below) and for a period of thirty (30) days after such delivery, the Escrow
Agent shall make no delivery of Escrow Shares pursuant to Section 10.3 unless
the Escrow Agent shall have received written authorization from the
Stockholders' Agents to make such delivery. After the expiration of such thirty
(30) day period, the Escrow Agent shall make delivery of the Escrow Shares in
the Escrow Fund in accordance with Section 10.3, provided that no such delivery
may be made if the Stockholders' Agents shall object in a written statement to
the claim made in the Officer's Certificate, and such statement shall have been
delivered to the Escrow Agent and to Chemdex prior to the expiration of such
thirty (30) day period.

   Section 10.7 Resolution of Conflicts.

     (a) In case the Stockholders' Agents shall so object in writing to any
  claim or claims by Chemdex made in any Officer's Certificate, Chemdex shall
  have thirty (30) days to respond in a written statement to the objection of
  the Stockholders' Agents. If after such thirty (30) day period there
  remains a dispute as to any claims, the Stockholders' Agents and Chemdex
  shall attempt in good faith for thirty (30) days to agree upon the rights
  of the respective parties with respect to each of such claims. If the
  Stockholders' Agents and Chemdex should so agree, a memorandum setting
  forth such agreement shall be prepared and signed by both parties and shall
  be furnished to the Escrow Agent. The Escrow Agent shall be entitled to
  rely on any such memorandum and shall distribute the Escrow Shares from the
  Escrow Fund in accordance with the terms of the memorandum.

     (b) If no such agreement can be reached after good faith negotiation,
  either Chemdex or the Stockholders' Agents may, by written notice to the
  other, demand arbitration of the matter unless the amount of the damage or
  loss is at issue in pending litigation with a third party, in which event
  arbitration shall not be commenced until such amount is ascertained or both
  parties agree to arbitration; and in either such event the matter shall be
  settled by arbitration conducted by three arbitrators. Within fifteen (15)
  days after such written notice is sent, Chemdex (on the one hand) and the
  Stockholders' Agents (on the other hand) shall each select one arbitrator,
  and the two arbitrators so selected shall select a third arbitrator. The
  decision of the arbitrators as to the validity and amount of any claim in
  such Officer's Certificate shall be binding and conclusive upon the parties
  to this Agreement, and notwithstanding anything in Section 10.3, the Escrow
  Agent shall be entitled to act in accordance with such decision and make or
  withhold payments out of the Escrow Fund in accordance with such decision.

     (c) Judgment upon any award rendered by the arbitrators may be entered
  in any court having jurisdiction. Any such arbitration shall be held in
  Santa Clara County, California under the commercial rules then in effect of
  the American Arbitration Association. The non-prevailing party to an
  arbitration shall pay its own expenses, the fees of each arbitrator, the
  administrative fee of the American Arbitration Association, and the
  expenses, including, without limitation, the reasonable attorneys' fees and
  costs, incurred by the prevailing party to the arbitration.

                                      A-39
<PAGE>

   Section 10.8 Stockholders' Agents.

     (a) Skip Klintworth and Brad Bond shall be constituted and appointed as
  agents (the "Stockholders' Agents") for and on behalf of the Former
  Promedix Stockholders to give and receive notices and communications, to
  authorize delivery to Chemdex of the Escrow Shares or other property from
  the Escrow Fund in satisfaction of claims by Chemdex, to object to such
  deliveries, to agree to, negotiate, enter into settlements and compromises
  of, and demand arbitration and comply with orders of courts and awards of
  arbitrators with respect to such claims, and to take all actions necessary
  or appropriate in the judgment of the Stockholders' Agents for the
  accomplishment of the foregoing. All actions of the Stockholders' Agents
  shall be taken jointly, not individually. Such agency may be changed by the
  holders of a majority in interest of the Escrow Shares from time to time
  upon not less than ten (10) days' prior written notice to Chemdex. No bond
  shall be required of the Stockholders' Agents, and the Stockholders' Agents
  shall receive no compensation for services. Notices or communications to or
  from the Stockholders' Agents shall constitute notice to or from each of
  the Former Promedix Stockholders.

     (b) The Stockholders' Agents shall not be liable for any act done or
  omitted hereunder as Stockholders' Agent while acting in good faith, and
  any act done or omitted pursuant to the advice of counsel shall be
  conclusive evidence of such good faith. The Former Promedix Stockholders
  shall severally and pro rata, in accordance with their Pro Rata Portion,
  indemnify the Stockholders' Agents and hold them harmless against any loss,
  liability or expense incurred without gross negligence or bad faith on the
  part of the Stockholders' Agents and arising out of or in connection with
  the acceptance or administration of their duties hereunder under this
  Agreement or the Escrow Agreement.

     (c) The Stockholders' Agents shall have reasonable access to information
  about Promedix and Chemdex and the reasonable assistance of Promedix's and
  Chemdex's officers and employees for purposes of performing their duties
  and exercising their rights under this Article X, provided that the
  Stockholders' Agents shall treat confidentially and not disclose any
  nonpublic information from or about Promedix or Chemdex to anyone (except
  on a need to know basis to individuals who agree to treat such information
  confidentially).

   Section 10.9 Actions of the Stockholders' Agents. A decision, act, consent
or instruction of the Stockholders' Agents shall constitute a decision of all
of the Former Promedix Stockholders for whom shares of Chemdex Common Stock
otherwise issuable to them are deposited in the Escrow Fund and shall be final,
binding and conclusive upon each such Former Promedix Stockholder, and the
Escrow Agent and Chemdex may rely upon any decision, act, consent or
instruction of the Stockholders' Agents as being the decision, act, consent or
instruction of each and every such Former Promedix Stockholder. The Escrow
Agent and Chemdex are hereby relieved from any liability to any person for any
acts done by them in accordance with such decision, act, consent or instruction
of the Stockholders' Agents.

   Section 10.10 Claims. In the event Chemdex becomes aware of a third-party
claim which Chemdex believes may result in a demand against the Escrow Fund,
Chemdex shall promptly notify the Stockholders' Agents of such claim, and the
Stockholders' Agents and the Former Promedix Stockholders for whom shares of
Chemdex Common Stock otherwise issuable to them are deposited in the Escrow
Fund shall be entitled, at their expense, to participate in any defense of such
claim. Chemdex shall have the right in its sole discretion to settle any such
claim; provided, however, that Chemdex may not effect the settlement of any
such claim without the consent of the Stockholders' Agents, which consent shall
not be unreasonably withheld. In the event that the Stockholders' Agents have
consented to any such settlement, the Stockholders' Agents shall have no power
or authority to object to the amount of any claim by Chemdex against the Escrow
Fund for indemnity with respect to such settlement in the amount agreed to.


                                      A-40
<PAGE>

                                   ARTICLE XI

                                 MISCELLANEOUS

   Section 11.1 Survival of Representations and Covenants. All representations
and warranties of Promedix contained in this Agreement shall survive the
Closing and any investigation at any time made by or on behalf of Chemdex until
the end of the Escrow Period. If Escrow Shares or other assets are retained in
the Escrow Fund beyond expiration of the period specified in the Escrow
Agreement, then (notwithstanding the expiration of such time period) the
representation, warranty, covenant or agreement applicable to such claim shall
survive until, but only for purposes of, the resolution of the claim to which
such retained Escrow Shares or other assets relate. All representations and
warranties of Chemdex contained in this Agreement shall terminate as of the
Effective Time. All covenants and other agreements of Promedix and Chemdex
contained in this Agreement shall survive the Closing until fulfilled or
waived.

   Section 11.2 Notices. All notices and other communications hereunder shall
be in writing and shall be deemed given if delivered personally, telecopied
(which is confirmed) or two business days after being mailed by registered or
certified mail (return receipt requested) to the parties at the following
addresses (or at such other address for a party as shall be specified by like
notice):

     (a)  if to Chemdex or Sub:
          Chemdex Corporation
          3950 Fabian Way
          Palo Alto, CA 94308
          Attention: Chief Executive Officer
          Fax No: (650) 813-0304
          Telephone No: (650) 813-0300

          with a copy to:

          Venture Law Group
          A Professional Corporation
          2775 Sand Hill Road
          Menlo Park, California 94025
          Attention: Steven J. Tonsfeldt
          Fax No: (650) 233-8386
          Telephone No: (650) 854-4488

     (b)  if to Promedix, to:

          Promedix, Inc.
          448 East Winchester Avenue, Suite 200
          Salt Lake City, Utah 84107
          Attention:
          Fax No: (801) 261-7475
          Telephone No: (800) 453-1264

          with a copy to:

          Orrick, Herrington & Sutcliffe LLP
          1020 Marsh Road
          Menlo Park, CA 94025
          Attention: Geoffrey P. Leonard, Esq.
          Fax No.: (650) 614-7401
          Fax No.: (650) 614-7470

                                      A-41
<PAGE>

   Section 11.3 Interpretation. When a reference is made in this Agreement to
Sections, such reference shall be to a Section of this Agreement unless
otherwise indicated. The table of contents and headings contained in this
Agreement are for reference purposes only and shall not affect in any way the
meaning or interpretation of this Agreement. Whenever the words "include,"
"includes" or "including" is used in this Agreement they shall be deemed to be
followed by the words "without limitation." Whenever the words "to the
knowledge of Promedix" or "known to Promedix" or similar phrases are used in
this Agreement, they mean to the actual knowledge, after reasonable inquiry, of
Skip Klintworth and all other executive officers of Promedix.

   Section 11.4 Counterparts. This Agreement may be executed in two or more
counterparts, all of which shall be considered one and the same agreement and
shall become effective when two or more counterparts have been signed by each
of the parties and delivered to the other parties, it being understood that all
parties need not sign the same counterpart.

   Section 11.5 Entire Agreement; No Third Party Beneficiaries. This Agreement
(including the documents and the instruments referred to herein), the
Confidentiality Agreement, the Transaction Documents, and the Standstill
Agreement dated September 21, 1999 by and between Chemdex and Promedix (a)
constitute the entire agreement and supersedes all prior agreements and
understandings (including the Summary of Transaction Terms dated September 2,
1999 by and between Chemdex and Promedix and the Mutual Exclusive Negotiations
Agreement dated September 3, 1999 by and between Chemdex and Promedix, as
extended), both written and oral, among the parties with respect to the subject
matter hereof, and (b) are not intended to confer upon any person other than
the parties hereto (including without limitation any Promedix employees) any
rights or remedies hereunder.

   Section 11.6 Governing Law; Jurisdiction. This Agreement shall be governed
and construed in accordance with the laws of the State of Delaware without
regard to any applicable conflicts of law. Any action or proceeding initiated
under this Agreement or in connection with the subject matter hereof shall be
maintained in the County of Santa Clara, State of California, United States of
America, and each party hereby submits to the jurisdiction of the courts of the
State of California and the court of the United States of America for the
Northern District of the State of California for the purposes of any such
action or proceeding. Each party irrevocably waives to the fullest extent such
party may effectively do so, the defense of an inconvenient forum to the
maintenance of such action or proceeding and agrees that any process or any
paper to be served in connection therewith shall, if delivered or sent in
accordance with Section 11.2 of this Agreement, constitutes good, proper and
sufficient service thereof. Each party further irrevocably waives any trial by
jury.

   Section 11.7 Assignment. Neither this Agreement nor any of the rights,
interests or obligations hereunder shall be assigned by any of the parties
hereto (whether by operation of law or otherwise) without the prior written
consent of the other parties. Subject to the preceding sentence, this Agreement
will be binding upon, inure to the benefit of and be enforceable by the parties
and their respective successors and assigns.

   Section 11.8 Amendment. This Agreement may be amended by the parties hereto,
at any time before or after approval of matters presented in connection with
the Merger by the stockholders of Promedix, but after any such stockholder
approval, no amendment shall be made which by law requires the further approval
of stockholders without obtaining such further approval. This Agreement may not
be amended except by an instrument in writing signed on behalf of each of the
parties hereto.

   Section 11.9 Extension; Waiver. At any time prior to the Effective Time, the
parties hereto may, to the extent legally allowed, (i) extend the time for the
performance of any of the obligations or the other acts of the other parties
hereto, (ii) waive any inaccuracies in the representations or warranties
contained herein or in any document delivered pursuant hereto and (iii) waive
compliance with any of the agreements or conditions contained herein. Any
agreement on the part of a party hereto to any such extension or waiver shall
be valid only if set forth in a written instrument signed on behalf of such
party.


                                      A-42
<PAGE>

   Section 11.10 Specific Performance. The parties hereto agree that
irreparable damage would occur in the event that any of the provisions of this
Agreement were not performed in accordance with their specific terms or were
otherwise breached. It is accordingly agreed that the parties shall be entitled
to injunctive relief to prevent breaches of this Agreement and to enforce
specifically the terms and provisions hereof in any court of the United States
or any state having jurisdiction, this being in addition to any other remedy to
which they are entitled at law or in equity.

                            [Signature Page Follows]

                                      A-43
<PAGE>

   IN WITNESS WHEREOF, Chemdex, Sub and Promedix have caused this Agreement and
Plan of Merger to be signed by their respective officers thereunto duly
authorized as of the date first written above.

                                          CHEMDEX CORPORATION

                                              /s/ David P. Perry
                                          By: _________________________________

                                                David P. Perry
                                          Name: _______________________________

                                                CEO
                                          Title: ______________________________

                                          POPCORN ACQUISITIONS CORP.

                                              /s/ David P. Perry
                                          By: _________________________________

                                                David P. Perry
                                          Name: _______________________________

                                                CEO
                                          Title: ______________________________

                                          PROMEDIX.COM, INC.

                                              /s/ W.C Klintworth
                                          By: _________________________________

                                                W. C Klintworth, Jr.
                                          Name: _______________________________

                                                CEO
                                          Title: ______________________________

                                      A-44
<PAGE>

                                   EXHIBIT A

                                VOTING AGREEMENT

                                      A-45
<PAGE>

                                VOTING AGREEMENT

   THIS VOTING AGREEMENT (this "Agreement") is made and entered into as of
September    , 1999, between Chemdex Corporation ("Chemdex"), a Delaware
corporation, and the undersigned stockholder (the "Stockholder") of
Promedix.com, Inc., a Delaware corporation ("Promedix").

                                    RECITALS

   A. Concurrently with the execution of this Agreement, Chemdex, Promedix and
Popcorn Acquisitions Corp., a Delaware corporation and wholly-owned subsidiary
of Chemdex ("Merger Sub"), have entered into an Agreement and Plan of Merger
(the "Merger Agreement"), which provides for the merger (the "Merger") of
Merger Sub with and into Promedix and the conversion of each outstanding share
of Promedix's capital stock into shares of Chemdex Common Stock.

   B. As a condition to its willingness to enter into the Merger Agreement,
Chemdex has requested that the Stockholder agree to certain matters regarding
the retention and voting of the Shares (as defined below) in connection with
the Merger.

                                   AGREEMENT

   The parties agree as follows:

     1. Agreement to Retain Shares.

       1.1 Transfer and Encumbrance. The Stockholder agrees not to
    transfer, sell, exchange, pledge or otherwise dispose of or encumber
    (in each case, other than as a result of death) any shares of capital
    stock of Promedix owned or beneficially held by him (the "Shares") or
    New Shares, as defined in Section 1.2 below, or to make any offer or
    agreement relating thereto, at any time prior to the Expiration Date.
    As used herein, the term "Expiration Date" shall mean the earlier to
    occur of (i) such date and time as the Merger shall become effective in
    accordance with the terms and provisions of the Merger Agreement, or
    (ii) the date on which the Merger Agreement shall be terminated in
    accordance with Section 9.1 thereof.

       1.2 Additional Purchases. The Stockholder agrees that any shares of
    capital stock of Promedix that such Stockholder shall purchase or with
    respect to which such Stockholder shall otherwise acquire beneficial
    ownership after the execution of this Agreement and prior to the
    Expiration Date (the "New Shares") shall be subject to the terms and
    conditions of this Agreement to the same extent as if they constituted
    Shares.

     2. Agreement to Vote Shares and Grant Proxy. At every meeting of the
  stockholders of Promedix called with respect to any of the following, and
  on every action or approval by written consent of the stockholders of
  Promedix with respect to any of the following, the Stockholder agrees to
  vote the Shares and any New Shares in favor of approval of the Merger
  Agreement and the Merger and any matter that could reasonably be expected
  to facilitate the Merger, including the manner in which the Escrow Fund
  under the Merger Agreement is to be established as contemplated by Section
  2.2 and Article X of the Merger Agreement. The Stockholder further agrees
  not, directly or indirectly, to solicit or encourage any offer from any
  party concerning the possible disposition of all or any substantial portion
  of Promedix's business, assets or capital stock. In the event Promedix's
  board of directors does not call a meeting to approve the Merger, the
  Stockholder agrees to take all action necessary to call a meeting to
  approve the Merger or to approve the Merger by written consent. In order to
  effectuate the foregoing, the Stockholder does hereby constitute and
  appoint Chemdex, or any nominee of Chemdex, with full power of
  substitution, from the date hereof to the Expiration Date, as its true and
  lawful proxy, for and in its name, place and

                                      A-46
<PAGE>

  stead, including the right to sign its name (as stockholder) to any
  consent, certificate or other document relating to Promedix, for the sole
  purpose of causing the Shares and any New Shares to be voted in the manner
  contemplated by this Section 2. The parties acknowledge that the proxy
  provided for here is irrevocable and coupled with an interest.

     3. Representations, Warranties and Covenants of the Stockholder. The
  Stockholder represents, warrants and covenants to Chemdex as follows:

       3.1 Ownership of Shares. The Stockholder (together with such
    Stockholder's spouse, if applicable) is the sole beneficial and record
    owner and holder of the Shares, which at the date hereof and at all
    times up until the Expiration Date, will be free and clear of any
    liens, claims, options, charges, security interests, equities, options,
    warrants, rights to purchase (including, without limitation,
    restrictions on rights of disposition other than those imposed by
    applicable securities laws), third party rights of any nature or other
    encumbrances; and (ii) does not own any shares of capital stock of
    Promedix other than the Shares.

       3.2 Authority; Due Execution. The Stockholder has full power and
    authority to make, enter into and carry out the terms of this
    Agreement. The Stockholder has duly executed and delivered this
    Agreement and (assuming the due authorization, execution and delivery
    of this Agreement by Chemdex) this Agreement constitutes a valid and
    binding obligation of the Stockholder.

     4. Representations, Warranties and Covenants of Chemdex. Chemdex
  represents, warrants and covenants to the Stockholder as follows:

       4.1 Due Authorization. This Agreement has been authorized by all
    necessary corporate action on the part of Chemdex and has been duly
    executed by a duly authorized officer of Chemdex.

       4.2 Validity; No Conflict. This Agreement constitutes the legal,
    valid and binding obligation of Chemdex. Neither the execution of this
    Agreement by Chemdex nor the consummation of the transactions
    contemplated hereby will result in a breach or violation of the terms
    of any agreement by which Chemdex is bound or by any decree, judgment,
    order, law or regulation now in effect of any court or other
    governmental body applicable to Chemdex.

     5. Termination. This Agreement shall terminate and shall have no further
  force or effect as of the Expiration Date.

     6. Miscellaneous.

       6.1 Severability.  If any term, provision, covenant or restriction
    of this Agreement is held by a court of competent jurisdiction to be
    invalid, void or unenforceable, then the remainder of the terms,
    provisions, covenants and restrictions of this Agreement shall remain
    in full force and effect and shall in no way be affected, impaired or
    invalidated.

       6.2 Binding Effect and Assignment. This Agreement and all of the
    provisions hereof shall be binding upon and inure to the benefit of the
    parties hereto and their respective successors and permitted assigns,
    but, except as otherwise specifically provided herein, neither this
    Agreement nor any of the rights, interests or obligations of the
    parties hereto may be assigned by either of the parties without the
    prior written consent of the other.

       6.3 Amendments and Modification. This Agreement may not be modified,
    amended, altered or supplemented except upon the execution and delivery
    of a written agreement executed by the parties hereto.

       6.4 Specific Performance; Injunctive Relief. The parties hereto
    acknowledge that Chemdex will be irreparably harmed and that there will
    be no adequate remedy at law for a violation of any of

                                      A-47
<PAGE>

    the covenants or agreements of the Stockholder set forth herein.
    Therefore, it is agreed that, in addition to any other remedies that
    may be available to Chemdex upon any such violation, Chemdex shall have
    the right to enforce such covenants and agreements by specific
    performance, injunctive relief or by any other means available to
    Chemdex at law or in equity.

       6.5 Governing Law. This Agreement shall be governed by, construed
    and enforced in accordance with, the internal laws of the State of
    Delaware as such laws are applied to contracts entered into and to be
    performed entirely within Delaware.

       6.6 Entire Agreement. This Agreement contains the entire
    understanding of the parties in respect of the subject matter hereof,
    and supersedes all prior negotiations and understandings between the
    parties with respect to such subject matter.

       6.7 Notices. Any notice or other communication required or permitted
    to be delivered under this Agreement shall be in writing and shall be
    deemed properly delivered, given and received when delivered (by hand,
    by registered mail, by courier or express delivery service or by
    facsimile confirmation) to the address or facsimile telephone number
    set forth beneath the name of such party below (or to such other
    address or facsimile telephone number as such party shall have
    specified in a written notice given to the other party):

     If to Chemdex:
           Chemdex
           3950 Fabian Way
           Palo Alto, CA 94308
           Attention: Chief Executive Officer
           Telephone No.: (650) 813-0300
           Telecopy No.: (650) 813-0304

  with a copy at the same address to the attention of the General Counsel and
  Secretary and with a copy to:

           Venture Law Group
           A Professional Corporation
           2800 Sand Hill Road
           Menlo Park, California 94025
           Attention: Steven J. Tonsfeldt
           Telephone No.: (650) 854-4488
           Telecopy No.: (650) 233-8386

     If to Stockholder:

  at the address or facsimile phone number set forth below Stockholder's
  signature on the signature page hereof.

     With a copy to:
           Orrick, Herrington & Sutcliffe LLP
           1020 Marsh Road
           Menlo Park, CA 94025
           Attention: Geoffrey P. Leonard, Esq.
           Telephone No.: (650) 614-7470
           Telecopy No.: (650) 614-7401

                                      A-48
<PAGE>

       6.8 Counterparts. This Agreement may be executed in several
    counterparts, each of which shall be an original, but all of which
    together shall constitute one and the same agreement.

       6.9 Effect of Headings. The section headings herein are for
    convenience only and shall not affect the construction or
    interpretation of this Agreement.

       6.10 No Limitation on Actions of the Stockholder as Director. In the
    event the Stockholder is a director of Promedix, notwithstanding
    anything to the contrary in this Agreement, nothing in this Agreement
    is intended or shall be construed to require the Stockholder to take or
    in any way limit any action that the Stockholder may take to discharge
    the Stockholder's fiduciary duties as a director of Promedix.

                            [Signature Page Follows]

                                      A-49
<PAGE>

   IN WITNESS WHEREOF, the parties have caused this Voting Agreement to be duly
executed on the day and year first written above.

                                          CHEMDEX CORPORATION

                                          By: _________________________________

                                          Name: _______________________________

                                          Title: ______________________________

                                          STOCKHOLDER

                                          _____________________________________

                                          Name: _______________________________

                                      A-50
<PAGE>

                                   EXHIBIT B

                              EMPLOYMENT AGREEMENT

                                      A-51
<PAGE>

                              CHEMDEX CORPORATION
                                3950 Fabian Way
                              Palo Alto, CA 94303

                                                              September 21, 1999

(Name of Employee)
c/o Promedix, Inc.
448 East Winchester Avenue, Suite 200
Salt Lake City, UT 84107

Dear          :

   In connection with the proposed acquisition of Promedix.com, Inc.
("Promedix") pursuant to that Agreement and Plan of Merger dated as of
September 21, 1999 (the "Merger Agreement"), Chemdex Corporation (the
"Company") is pleased to offer you employment on the following terms:

   Position. You will serve in a full-time capacity as     of the Promedix.com
subsidiary of the Company. You will report to the     of the Company. Your role
at the present time includes               .

   Cash Compensation. You will be paid a monthly salary of not less than
$         which is equivalent to $          on an annual basis, payable in
semi-monthly installments in accordance with the Company's standard payroll
practices for salaried employees.

   Proprietary Information and Inventions Agreement. Like all Company
employees, you will be required, as a condition to your employment with the
Company, to sign the Company's standard Employee Confidentiality and Inventions
Agreement, a copy of which is attached hereto as Exhibit A.

   Change of Control Agreement. You will be entitled to enter into the standard
Change of Control Agreement for the Company's officers in the form attached
hereto as Exhibit B.

   Noncompetition Agreement. As a condition to the Company's entrance into the
Merger Agreement and the consummation of the transactions contemplated in the
Merger Agreement, you will be required to execute the Noncompetition Agreement
in the form attached hereto as Exhibit C.

   Stock Restriction Agreement. As a condition to the Company's entrance into
the Merger Agreement and the consummation of the transactions contemplated in
the Merger Agreement, you will be required to execute the Stock Restriction
Agreement in the form attached hereto as Exhibit D.

   Period of Employment. Your employment with the Company will commence
immediately after the consummation of the transactions contemplated by the
Merger Agreement. Your employment with the Company will be "at will," meaning
that either you or the Company will be entitled to terminate your employment at
any time and for any reason, with or without cause. Any contrary
representations which may have been made to you are superseded by this offer.
This is the full and complete agreement between you and the Company on this
term. Although your job duties, title, compensation and benefits, as well as
the Company's personnel policies and procedures, may change from time to time,
the "at will" nature of your employment may only be changed in an express
written agreement signed by you and a duly authorized officer of the Company.

   Severance. In the event your employment with the Company is either
terminated by the Company without Cause or as a result of a Constructive
Termination during the first year following the closing of the transactions
contemplated by the Merger Agreement, your Company stock and options will
immediately vest in full. After the initial one-year period, if your employment
with the Company is either terminated by the

                                      A-52
<PAGE>

Company without Cause or as a result of a Constructive Termination, your
Company stock and options shall become vested on the effective date of such
termination as if you had been employed by the Company for an additional twelve
months following such termination. In addition, in the event your employment
with the Company is either terminated by the Company without Cause or as a
result of a Constructive Termination at any time, you will be paid an amount
equal to the greater of (i) six (6) months of your then-current salary, or (ii)
$100,000, in each case payable in twelve (12) equal semi-monthly installments
in accordance with the Company's standard payroll practices for salaried
employees. In return for these severance benefits, you agree that you will: (a)
sign an agreement releasing the Company and its officers, directors,
stockholders and employees from any and all employment-related claims with
standard provisions for agreements of this type; (b) reaffirm that you are
bound by the provisions of your Employee Confidentiality Agreement and other
agreements between you and the Company, including any Noncompetition Agreement;
(c) not make any disparaging remarks about the Company or its officers,
directors, employees, products or business practices.

   "Cause" means (a) willful and repeated failure to comply with the lawful
directions of the Board, (b) gross negligence or willful misconduct in the
performance of your duties to the Company, (c) commission of any act of fraud
against, or the misappropriation of material property belonging to, the Company
or (d) conviction of a crime that is materially injurious to the business or
reputation of the Company, in each case as determined in good faith by the
Board.

   "Constructive Termination" means your voluntary termination, upon 30 days
prior written notice to the Company, following (a) a material reduction or
change in your job duties, responsibilities and requirements inconsistent with
your position with the Company and your prior duties, responsibilities and
requirements; (b) any reduction of greater than 5% in your base compensation
(including salary, benefits, incentive payments and bonuses), other than in
connection with a general decrease in base salaries for most officers of the
Company and any successor corporation; or (d) your refusal to relocate to a
facility or location more than 50 miles from the current location of the
Promedix.com subsidiary.

   Proof of Right to Work. For purposes of federal immigration law, you will be
required to provide to the Company documentary evidence of your identity and
eligibility for employment in the United States. Such documentation must be
provided to us within three (3) business days of your date of hire, or our
employment relationship with you may be terminated and, in such event, you
would not be entitled to the severance payment set forth in the preceding
paragraph.

   Withholding Taxes. All forms of compensation referred to in this letter are
subject to reduction to reflect applicable withholding and payroll taxes.

   Entire Agreement. This letter and the Exhibits attached hereto contain all
of the terms of your employment with the Company and supersede any prior
understandings or agreements, whether oral or written, between you and the
Company.

   Amendment and Governing Law. This letter agreement may not be amended or
modified except by an express written agreement signed by you and a duly
authorized officer of the Company. The terms of this letter agreement and the
resolution of any disputes will be governed by California law, except as
provided in the Noncompetition Agreement.

                                      A-53
<PAGE>

   We hope that you find the foregoing terms acceptable. You may indicate your
agreement with these terms and accept this offer by signing and dating the
enclosed duplicate original of this letter and the enclosed Exhibits and
returning them to me.

                                          Very truly yours,

                                          CHEMDEX CORPORATION

                                          David Perry
                                          Chief Executive Officer

                                          I have read and accept this
                                           employment offer:


                                          _____________________________________
                                          Signature of Employee.

                                          Dated   , 1999

                                      A-54
<PAGE>

               Employee Confidentiality and Inventions Agreement

   In consideration of my employment with Chemdex Corporation or its
subsidiaries (together, "the Company"), I agree as follows:

     1. Nondisclosure and Nonuse of Confidential Information. Except as
  required by the nature of my duties or with the prior written approval of
  an authorized officer of the Company, I will never, during my employment or
  thereafter, use or disclose any confidential information of the Company or
  any of its customers, including without limitation customer lists, market
  research, strategic plans or other information or discoveries, inventions,
  improvements, know-how, methods or other trade secrets, whether developed
  by me or others. I will comply with the Company's policies and procedures
  for the protection of confidential information.

     2. Use and Return of Documents. I will not disclose any documents,
  records, tapes and other media that contain confidential information and
  will not copy any such material or remove it from the Company's premises,
  except as required by the nature of my duties or as approved by an
  authorized officer of the Company. Upon termination of my employment, I
  will return to the Company all copies of documents, records, tapes, and
  other media that contain confidential information.

     3. Assignments of Rights. I will promptly disclose to the Company all
  inventions, discoveries, methods, processes, works, and concepts (whether
  or not patentable or copyrightable or constituting trade secrets)
  conceived, created, developed or reduced to practice by me (whether alone
  or with others, and whether or not during normal business hours or on or
  off the Company premises) during my employment that relate to any present
  or proposed activity of the Company ("Property"). I assign to the Company
  my full right, title and interest to all Property. I agree to execute such
  documents and take such action reasonably requested by the Company in
  connection with the Property. I will not charge the Company for my time
  spent in complying with this obligation. All copyrightable works that I
  create shall be considered "works made for hire."

     4. This Agreement does not apply to Property which qualifies fully as a
  nonassignable invention under the provisions of Section 2870 of the
  California Labor Code as follows: "THIS IS TO NOTIFY you in accordance with
  Section 2872 of the California Labor Code that the foregoing Agreement
  between you and the Company does not require you to assign or offer to
  assign to the Company any invention that you developed entirely on your own
  time without using the Company's equipment, supplies, facilities or trade
  secret information except for those inventions that either: (1) relate at
  the time of conception or reduction to practice of the invention to the
  Company's business, or actual or demonstrably anticipated research or
  development of the Company; or (2) result from any work performed by you
  for the Company. To the extent a provision in the foregoing Agreement
  purports to require you to assign an invention otherwise excluded from the
  preceding paragraph, the provision is against the public policy of this
  state and is unenforceable. This limited exclusion does not apply to any
  patent or invention covered by a contract between the Company and the
  United States or any of its agencies requiring full title to such patent or
  invention to be in the United States.

     5. Non-Recruitment. For a period of one year after termination of my
  employment, I will not hire or assist in hiring any employees of the
  Company or encourage any employee of the Company to become employed in any
  business competitive with the Company's business, nor encourage any
  consultant or supplier of the Company to discontinue its relationship with
  the Company.

     6. Restricted Activities. I agree that some restrictions on my
  activities during and after my employment are necessary to protect the
  goodwill, confidential information and other legitimate interests of the
  Company. While employed, I will not undertake any planning for any outside
  business competitive with the Company. During my employment and for one
  year after my employment terminates, I will not engage in any business in
  the United States, whether as an employee, consultant, or otherwise, that
  is competitive with the business of the Company conducted or under
  consideration during my employment and will not accept employment or a
  consulting position with any business that is, or at any time within one
  year prior to my termination was, a customer of the Company. I may,
  however, own 5% or less of the securities of any publicly traded company.

                                      A-55
<PAGE>

     7. Employment. Except as provided otherwise in any other agreement
  between me and the Company, my employment is "at will" and either the
  Company or I may terminate my employment at any time with or without cause.
  My employment and my execution and performance of this Agreement do not
  conflict with any obligations of mine to third parties. I will not disclose
  to the Company any proprietary information of any third party without its
  consent.

     8. Remedies. I understand that if I violate this Agreement the harm to
  the Company could be irreparable. I agree that, in addition to any other
  remedies provided by law, the Company will be entitled to obtain injunctive
  relief against any such violations without having to post a bond.

     9. Consent to Jurisdiction. I consent to the jurisdiction of the federal
  and state courts in California in respect of any matter relating to this
  Agreement and agree that any dispute relating to this Agreement shall be
  litigated exclusively in such courts.

     10. General. This Agreement shall inure to the benefit of the Company
  and any successor of the Company by reorganization, merger, consolidation
  or liquidation and any assignee of all or substantially all of the business
  or assets of the Company or of any division or line of business of the
  Company with which I am at any time associated. This Agreement will take
  effect as a sealed instrument, will continue in effect after termination of
  my employment for any reason, and will be governed by California law. If
  any part of this Agreement is held invalid or unenforceable, the remainder
  of this Agreement will be still enforceable.

Date: _______________________________     Name: _______________________________
                                                (Employee)

                                          ACCEPTED:

                                          CHEMDEX CORPORATION

                                          By: _________________________________

                                          Title: ______________________________

                                      A-56
<PAGE>

                          CHANGE OF CONTROL AGREEMENT

   This Change of Control Agreement (the "Agreement") is made and entered into
effective as of (Date), by and between (Employee) (the "Employee") and Chemdex
Corporation, a Delaware corporation (the "Company").

                                    RECITALS

   A. It is expected that another company or other entity may from time to time
consider the possibility of acquiring the Company or that a change in control
may otherwise occur, with or without the approval of the Company's Board of
Directors (the "Board"). The Board recognizes that such consideration can be a
distraction to the Employee and can cause the Employee to consider alternative
employment opportunities. The Board has determined that it is in the best
interests of the Company and its stockholders to assure that the Company will
have the continued dedication and objectivity of the Employee, notwithstanding
the possibility, threat or occurrence of a Corporate Transaction (as defined
below) of the Company.

   B. The Board believes that it is in the best interests of the Company and
its stockholders to provide the Employee with an incentive to continue his or
her employment with the Company.

   C. The Board believes that it is imperative to provide the Employee with
certain benefits upon termination of the Employee's employment in connection
with a Corporate Transaction, which benefits are intended to provide the
Employee with financial security and provide sufficient encouragement to the
Employee to remain with the Company notwithstanding the possibility of a
Corporate Transaction.

   D. To accomplish the foregoing objectives, the Board of Directors has
directed the Company, upon execution of this Agreement by the Employee, to
agree to the terms provided in this Agreement.

   E. Certain capitalized terms used in the Agreement are defined in Section 3
below.

   In consideration of the mutual covenants herein contained, and in
consideration of the continuing employment of Employee by the Company, the
parties agree as follows:

     1. At-Will Employment. The Company and the Employee acknowledge that the
  Employee's employment is and shall continue to be at-will, as defined under
  applicable law. If the Employee's employment terminates for any reason,
  including (without limitation) any termination prior to a Corporate
  Transaction, the Employee shall not be entitled to any payments or
  benefits, other than as provided by this Agreement, or as may otherwise be
  available in accordance with the terms of Employee's offer letter from the
  Company (the "Offer Letter") and the Company's established employee plans
  and written policies at the time of termination. The terms of this
  Agreement shall terminate upon the earlier of (i) the date on which
  Employee ceases for any reason to be employed by the Company prior to the
  occurrence of a Corporate Transaction, (ii) the date that all obligations
  of the parties hereunder have been satisfied, or (iii) one (1) year after
  the closing of any Corporate Transaction. A termination of the terms of
  this Agreement pursuant to the preceding sentence shall be effective for
  all purposes, except that such termination shall not affect the payment or
  provision of compensation or benefits on account of a termination of
  employment occurring prior to the termination of the terms of this
  Agreement.

     2. Stock Options and Restricted Stock. Subject to Sections 4 and 5
  below, in the event of a Corporate Transaction, if either Employee's
  employment with the Company is terminated by the surviving entity without
  Cause or by Employee as the result of a Constructive Termination by the
  surviving entity within twelve months of the closing of the Corporate
  Transaction, each unvested stock option granted for the Company's
  securities held by Employee and any shares of the Company's Common Stock
  that are subject to a right of repurchase by the Company pursuant to the
  terms of a Restricted Stock Purchase Agreement ("Restricted Stock") held by
  the Employee shall become vested on the effective date of the termination
  or Constructive Termination as if Employee had been employed by the
  surviving entity for an

                                      A-57
<PAGE>

  additional six months following such termination. Each stock option shall
  otherwise vest in accordance with the provisions of the Stock Option
  Agreement and the Company's 1998 Stock Option Plan pursuant to which such
  option was granted and each Share of Restricted Stock shall be freely
  transferable to the extent so vested in accordance with the provisions of
  the Restricted Stock Purchase Agreement pursuant to which such stock was
  purchased by Employee.

     3. Definition of Terms. The following terms referred to in this
  Agreement shall have the following meanings:

       (a) Corporate Transaction. "Corporate Transaction" shall mean the
    occurrence of either of the following stockholder-approved events to
    which the Company is a party:

         (i) a merger or consolidation in which securities possessing more
      than fifty percent (50%) of the total combined voting power of the
      Company's outstanding securities are transferred to a person or
      persons different from the persons holding those securities
      immediately prior to such transaction; or

         (ii) the sale, transfer or other disposition of all or
      substantially all of the Company's assets in complete liquidation or
      dissolution of the Company.

       (b) Cause. "Cause" shall mean:

         (i) conviction of a felony or a crime involving fraud or moral
      turpitude; or

         (ii) intentional or reckless conduct or gross negligence
      materially harmful to the surviving entity after a Corporation
      Transaction, including violation of a non-competition or
      confidentiality agreement.

    Cause shall not include poor performance in the achievement of the
    Employee's job objectives or the death or physical disability of the
    Employee.

       (c) Constructive Termination. "Constructive Termination" shall mean
    the Employee's voluntary termination, upon 30 days prior written notice
    to the Company, following:

         (i) a material reduction or change in the Employee's job duties,
      responsibilities and requirements inconsistent with the Employee's
      position with the Company and the Employee's prior duties,
      responsibilities and requirements;

         (ii) any reduction of greater than 5% in the Employee's base
      compensation (including salary, benefits, incentive payments and
      bonuses), other than in connection with a general decrease in base
      salaries for most officers of the Company and any successor
      corporation; or

         (iii) the Employee's refusal to relocate to a facility or
      location more than 50 miles from the Company's current location.

     4. Limitation on Payments. In the event that the benefits provided for
  in this Agreement to the Employee (i) constitute "parachute payments"
  within the meaning of Section 280G of the Internal Revenue Code of 1986, as
  amended (the "Code") and (ii) but for this Section, would be subject to the
  excise tax imposed by Section 4999 of the Code, then the Employee's
  benefits under Section 2 shall be payable either:

       (a) in full, or

       (b) as to such lesser amount which would result in no portion of
    such severance benefits being subject to excise tax under Section 4999
    of the Code,

  whichever of the foregoing amounts, taking into account the applicable
  federal, state and local income taxes and the excise tax imposed by Section
  4999, results in the receipt by the Employee on an after-tax basis, of the
  greatest amount of benefits under Section 2 notwithstanding that all or
  some portion of such severance benefits may be taxable under Section 4999
  of the Code. Unless the Company and the Employee otherwise agree in
  writing, any determination required under this Section 4 shall be made in

                                      A-58
<PAGE>

  writing by the Company's independent public accountants (the
  "Accountants"), whose determination shall be conclusive and binding upon
  the Employee and the Company for all purposes. For purposes of making the
  calculations required by this Section 4, the Accountants may make
  reasonable assumptions and approximations concerning applicable taxes and
  may rely on reasonable, good faith interpretations concerning the
  application of Section 280G and 4999 of the Code. The Company and the
  Employee shall furnish to the Accountants such information and documents as
  the Accountants may reasonably request in order to make a determination
  under this Section. The Company shall bear all costs the Accountants may
  reasonably incur in connection with any calculations contemplated by this
  Section 4.

     5. Certain Business Combinations. In the event it is determined by the
  Board, upon consultation with Company management and the Company's
  independent auditors, that the enforcement of any Section of this
  Agreement, including, but not limited to, Section 2 hereof, which allows
  for the acceleration of vesting of stock options and Restricted Stock
  granted for the Company's securities upon the effective date of a Corporate
  Transaction would preclude accounting for any proposed business combination
  of the Company involving a Corporate Transaction as a pooling of interests,
  and the Board otherwise desires to approve such a proposed business
  transaction which requires as a condition to the closing of such
  transaction that it be accounted for as a pooling of interests, then any
  such Section of this Agreement shall be null and void. For purposes of this
  Section 5, the Board's determination shall require the unanimous approval
  of the non-employee Board members.

     6. Successors. Any successor to the Company (whether direct or indirect
  and whether by purchase, lease, merger, consolidation, liquidation or
  otherwise) to all or substantially all of the Company's business and/or
  assets shall assume the obligations under this Agreement and agree
  expressly to perform the obligations under this Agreement in the same
  manner and to the same extent as the Company would be required to perform
  such obligations in the absence of a succession. The terms of this
  Agreement and all of the Employee's rights hereunder shall inure to the
  benefit of, and be enforceable by, the Employee's personal or legal
  representatives, executors, administrators, successors, heirs,
  distributees, devisees and legatees.

     7. Notice. Notices and all other communications contemplated by this
  Agreement shall be in writing and shall be deemed to have been duly given
  when personally delivered or when mailed by U.S. registered or certified
  mail, return receipt requested and postage prepaid. Mailed notices to the
  Employee shall be addressed to the Employee at the home address which the
  Employee most recently communicated to the Company in writing. In the case
  of the Company, mailed notices shall be addressed to its corporate
  headquarters, and all notices shall be directed to the attention of its
  Secretary.

     8. Miscellaneous Provisions.

       (a) No Duty to Mitigate. The Employee shall not be required to
    mitigate the amount of any benefit contemplated by this Agreement
    (whether by seeking new employment or in any other manner), nor, except
    as otherwise provided in this Agreement, shall any such benefit be
    reduced by any earnings that the Employee may receive from any other
    source.

       (b) Waiver. No provision of this Agreement shall be modified, waived
    or discharged unless the modification, waiver or discharge is agreed to
    in writing and signed by the Employee and by an authorized officer of
    the Company (other than the Employee). No waiver by either party of any
    breach of, or of compliance with, any condition or provision of this
    Agreement by the other party shall be considered a waiver of any other
    condition or provision or of the same condition or provision at another
    time.

       (c) Whole Agreement. No agreements, representations or
    understandings (whether oral or written and whether express or implied)
    which are not expressly set forth in this Agreement have been made or
    entered into by either party with respect to the subject matter hereof.
    This Agreement supersedes any agreement of the same title and
    concerning similar subject matter dated prior to the

                                      A-59
<PAGE>

    date of this Agreement, and by execution of this Agreement both parties
    agree that any such predecessor agreement shall be deemed null and
    void.

       (d) Choice of Law. The validity, interpretation, construction and
    performance of this Agreement shall be governed by the laws of the
    State of California without reference to conflict of laws provisions.

       (e) Severability. If any term or provision of this Agreement or the
    application thereof to any circumstance shall, in any jurisdiction and
    to any extent, be invalid or unenforceable, such term or provision
    shall be ineffective as to such jurisdiction to the extent of such
    invalidity or unenforceability without invalidating or rendering
    unenforceable the remaining terms and provisions of this Agreement or
    the application of such terms and provisions to circumstances other
    than those as to which it is held invalid or unenforceable, and a
    suitable and equitable term or provision shall be substituted therefor
    to carry out, insofar as may be valid and enforceable, the intent and
    purpose of the invalid or unenforceable term or provision.

       (f) Arbitration. Any dispute or controversy arising under or in
    connection with this Agreement may be settled at the option of either
    party by binding arbitration in the County of San Mateo, California, in
    accordance with the rules of the American Arbitration Association then
    in effect. Judgment may be entered on the arbitrator's award in any
    court having jurisdiction. Punitive damages shall not be awarded.

       (g) Legal Fees and Expenses. The parties shall each bear their own
    expenses, legal fees and other fees incurred in connection with this
    Agreement.

       (h) No Assignment of Benefits. The rights of any person to payments
    or benefits under this Agreement shall not be made subject to option or
    assignment, either by voluntary or involuntary assignment or by
    operation of law, including (without limitation) bankruptcy,
    garnishment, attachment or other creditor's process, and any action in
    violation of this subsection (h) shall be void.

       (i) Employment Taxes. Any payments made pursuant to this Agreement
    will be subject to withholding of applicable income and employment
    taxes.

       (j) Assignment by Company. The Company may assign its rights under
    this Agreement to an affiliate, and an affiliate may assign its rights
    under this Agreement to another affiliate of the Company or to the
    Company; provided, however, that no assignment shall be made if the net
    worth of the assignee is less than the net worth of the Company at the
    time of assignment. In the case of any such assignment, the term
    "Company" when used in a section of this Agreement shall mean the
    corporation that actually employs the Employee.

       (k) Counterparts. This Agreement may be executed in counterparts,
    each of which shall be deemed an original, but all of which together
    will constitute one and the same instrument.

                            [Signature Page Follows]

                                      A-60
<PAGE>

   IN WITNESS WHEREOF, each of the parties has executed this Agreement, in the
case of the Company by its duly authorized officer, as of the day and year
first above written.

CHEMDEX CORPORATION                           (EMPLOYEE)

By: _______________________________           _________________________________

Title: ____________________________

                                      A-61
<PAGE>

                            NONCOMPETITION AGREEMENT

   THIS NONCOMPETITION AGREEMENT (this "Agreement") is entered into as of
September 21, 1999, by and between Chemdex Corporation, a Delaware corporation
("Chemdex") and (Name) ("Individual"), an employee of Promedix.com, Inc.
("Promedix.com").

                                    RECITALS

   A. Promedix.com is engaged in the business of operating an online exchange
for buyers and suppliers of specialty medical products.

   B. Individual is a stockholder and an employee of Promedix.com and has
confidential and proprietary information relating to the business and operation
of Promedix.com.

   C. Individual's covenant not to compete with Chemdex, as reflected in this
Agreement, is an essential part of the transactions described in that certain
Agreement and Plan of Merger dated as of September 21, 1999 (the "Merger
Agreement"), among Chemdex, Popcorn Acquisition Corp., a Delaware corporation
and a wholly owned subsidiary of Chemdex ("Sub"), and Promedix.com, whereby Sub
will be merged with and into Promedix.com (the transactions contemplated by the
Merger Agreement are referred to hereinafter as the "Merger").

   D. As a condition to its willingness to enter into the Merger Agreement,
Chemdex has required that Individual agree, and Individual has agreed, to the
noncompetition and nonsolicitation covenants and the confidentiality agreements
provided in this Agreement.

   E. References to Chemdex hereinafter shall include all subsidiaries of
Chemdex and shall include Promedix.com which is the surviving corporation in
the Merger.

                                   AGREEMENT

   NOW, THEREFORE, in consideration of the foregoing and to induce Chemdex to
consummate the transactions contemplated by the Merger Agreement, and for other
good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, Individual hereby covenants and agrees as follows:

     1. Noncompetition.

        (a) Individual and Chemdex agree that due to the nature of
    Individual's employment with Promedix.com, Individual has confidential
    and proprietary information relating to the business and operations of
    Promedix.com. Individual acknowledges that such information is of
    importance to the "Business" (as defined below) and will continue to be
    so after the Merger and that disclosure of such confidential
    information to others or the unauthorized use of such information by
    others would cause substantial loss and harm to Promedix.com and,
    following the Merger, Chemdex.

        (b) During the period which shall commence at the Effective Time
    and shall terminate on the first anniversary of the termination of
    Individual's employment with the Company (such period, the "Restricted
    Period"), Individual shall not directly or indirectly (including
    without limitation, through any Affiliate (as defined below) of
    Individual), own, manage, operate, control or otherwise engage or
    participate in, or be connected as an owner, partner, principal,
    creditor, salesman, guarantor, advisor, member of the board of
    directors of, employee of or consultant in any entity or business where
    such entity or business (i) devotes 20% or more of its resources to a
    division, group, or other subset of such entity or business, that is
    engaging in or is developing a business competitive with the Business
    or (ii) generates 20% or more of its gross revenues or earnings from a
    business competitive with the Business.

                                      A-62
<PAGE>

        (c) Notwithstanding the foregoing provisions of Section 1(b) and
    the restrictions set forth therein, Individual may own securities in
    any publicly held corporation that is covered by the restrictions set
    forth in Section 1(b), but only to the extent that Individual does not
    own, of record or beneficially, more than 1% of the outstanding
    beneficial ownership of such corporation.

        (d) The restrictions set forth in Section 1(b) shall apply to the
    United States (the "Business Area").

        (e) "Affiliate" as used herein, means, with respect to any person
    or entity, any person or entity directly or indirectly controlling,
    controlled by or under direct or indirect common control with such
    other person or entity.

        (f) "Business" as used herein means the operation of a business
    primarily engaged in health care e-commerce.

     2. Nonsolicitation of Chemdex Employees. During the Restricted Period,
  Individual shall not, without the prior written consent of Chemdex,
  directly or indirectly (including without limitation, through any Affiliate
  of Individual), solicit, request, cause or induce any person who is at the
  time, or 12 months prior thereto had been, an employee of or a consultant
  of Chemdex to leave the employ of or terminate such person's relationship
  with Chemdex.

     3. Nonsolicitation of Customers. During the Restricted Period,
  Individual shall not, directly or indirectly (including without limitation,
  through any Affiliate of Individual) (i) solicit, induce or attempt to
  induce any customer of Chemdex, including but not limited to any customer
  of Promedix.com that was a customer of Chemdex or Promedix.com while the
  Individual was an employee of Chemdex or Promedix.com, as the case may be,
  or during the Restricted Period, to cease doing business in whole or in
  part with Chemdex with respect to the Business; (ii) attempt to limit or
  interfere with any business agreement or relationship existing between
  Chemdex and/or its Affiliates with any third party; or (iii) make
  materially false statements, or take intentional actions, which are
  intended to disparage the business reputation of Chemdex (or its management
  team) or take any intentional actions which are intended to result in
  material harm to Chemdex's goodwill with its customers, content providers,
  bandwidth or other network infrastructure providers, vendors, employees,
  the media or the public.

     4. Confidentiality. Prior to the Effective Time, Individual will execute
  Chemdex's standard employee proprietary information and invention
  assignment agreement.

     5. Stay of Time. In the event that either party shall request a court of
  competent jurisdiction (collectively a "Court") or other entity or person
  mutually selected by the parties to determine whether the Individual has
  violated the provisions of this Agreement, the running of the time period
  of such provisions so violated shall be automatically suspended as of the
  date of such violation and shall resume on the date of the final order or
  remedy that the Court or other entity or person rules or determines that
  such violation occurred.

     6. Injunctive Relief. The remedy at law for any breach of this Agreement
  is and will be inadequate, and in the event of a breach or threatened
  breach by Individual of the provisions of Sections 1, 2 or 3 of this
  Agreement, Promedix.com and Chemdex shall be entitled to seek an injunction
  restraining Individual from the conduct which would constitute a breach of
  this Agreement. Nothing herein contained shall be construed as prohibiting
  Promedix.com or Chemdex from pursuing any other remedies available to it or
  them for such breach or threatened breach, including, without limitation,
  the recovery of damages from Individual.

     7. Separate Covenants. This Agreement shall be deemed to consist of a
  series of separate covenants, one for each line of business carried on by
  the Business and each county, state, country or other region included
  within the Business Area. The parties expressly agree that the character,
  duration and geographical scope of this Agreement are reasonable in light
  of the circumstances as they exist on the date upon which this Agreement
  has been executed. However, should a determination nonetheless be made

                                      A-63
<PAGE>

  by a court of competent jurisdiction at a later date that the character,
  duration or geographical scope of this Agreement is unreasonable in light
  of the circumstances as they then exist, then it is the intention and the
  agreement of Individual that this Agreement shall be construed by the court
  in such a manner as to impose only those restrictions on the conduct of
  Individual that are reasonable in light of the circumstances as they then
  exist and as are necessary to assure Promedix.com. and Chemdex of the
  intended benefit of this Agreement. If, in any judicial proceeding, a court
  shall refuse to enforce all of the separate covenants deemed included
  herein because, taken together, they are more extensive than necessary to
  assure Chemdex of the intended benefit of this Agreement, it is expressly
  understood and agreed among the parties hereto that those of such covenants
  that, if eliminated, would permit the remaining separate covenants to be
  enforced in such proceeding shall, for the purpose of such proceeding, be
  deemed eliminated from the provisions hereof.

     8. Severability. If any of the provisions of this Agreement shall
  otherwise contravene or be invalid under the laws of any state, country or
  other jurisdiction where this Agreement is applicable but for such
  contravention or invalidity, such contravention or invalidity shall not
  invalidate all of the provisions of this Agreement but rather it shall be
  construed, insofar as the laws of that state, country or jurisdiction are
  concerned, as not containing the provision or provisions contravening or
  invalid under the laws of that state or jurisdiction, and the rights and
  obligations created hereby shall be construed and enforced accordingly.

     9. Construction. This Agreement shall be construed and enforced in
  accordance with and governed by the laws of the State of Utah, without
  regard to principles of conflicts or choice of laws; provided, however,
  that with respect to activities occurring in a particular jurisdiction, the
  law of such jurisdiction shall apply solely to the extent it results in the
  greatest enforcement of the terms of this Agreement.

     10. Amendments and Waivers. This Agreement may be modified only by a
  written instrument duly executed by each party hereto. No breach of any
  covenant, agreement, warranty or representation shall be deemed waived
  unless expressly waived in writing by the party who might assert such
  breach. No waiver of any right hereunder shall operate as a waiver of any
  other right or of the same or a similar right on another occasion.

     11. Entire Agreement. This Agreement, together with the Merger
  Agreement, the offer letter to which this is attached and Chemdex's
  employee confidentiality and investors agreement, and the ancillary
  documents executed in connection therewith, contains the entire
  understanding of the parties relating to the subject matter hereof,
  supersedes all prior and contemporaneous agreements and understandings
  relating to the subject matter hereof and shall not be amended except by a
  written instrument signed by each of the parties hereto.

     12. Counterparts. This Agreement may be executed by the parties in
  separate counterparts, each of which, when so executed and delivered, shall
  be an original, but all of which, when taken as a whole, shall constitute
  one and the same instrument.

     13. Section Headings. The headings of each Section, subsection or other
  subdivision of this Agreement are for reference only and shall not limit or
  control the meaning thereof.

     14. Assignment. Neither this Agreement nor any right, remedy, obligation
  or liability arising hereunder or by reason hereof nor any of the documents
  executed in connection herewith may be assigned by any party without the
  consent of the other parties; provided, however, that Chemdex and
  Promedix.com may assign their rights hereunder, without the consent of
  Individual, to any entity that acquires or succeeds to the Business.

     15. Further Assurances. From time to time, at Chemdex's request and
  without further consideration, Individual shall execute and deliver such
  additional documents and take all such further action as reasonably
  requested by Promedix.com or Chemdex to be necessary or desirable to make
  effective, in the most expeditious manner possible, the terms of this
  Agreement.

                                      A-64
<PAGE>

     16. Notices. All notices and other communications hereunder shall be in
  writing and shall be deemed given if delivered personally or two business
  days after being mailed by registered or certified mail (return receipt
  requested) to the parties at the following addresses (or at such other
  address for a party as shall be specified by like notice):

     (a)  if to Chemdex:

         Chemdex Corporation
         3950 Fabian Way
         Palo Alto, CA 94303
         Attention: Chief Executive Officer

         with a copy to:

         Venture Law Group
         A Professional Corporation
         2775 Sand Hill Road
         Menlo Park, CA 94025
         Attention: Jeffrey Y. Suto

     (b)  if to Individual:

         to the address set forth below the name of Individual on the
  signature page hereof.

     17. Effectiveness. Notwithstanding any other provision of this
  Agreement, this Agreement shall become effective only upon the Effective
  Time, and if such Effective Time shall not occur prior to the termination
  of the Merger Agreement this Agreement shall be deemed void ab initio and
  have no further force or effect upon such termination of the Merger
  Agreement.

     19. Defined Terms. Capitalized terms not otherwise defined herein shall
  have the meanings given to them in the Merger Agreement.

                                    ********

                                      A-65
<PAGE>

   IN WITNESS WHEREOF, the parties hereto have executed this Noncompetition
Agreement as of the date first above written.

                                          CHEMDEX CORPORATION

                                          By: _________________________________

                                          Name: _______________________________

                                          Title: ______________________________

                                          INDIVIDUAL:

                                          _____________________________________
                                                         (Name)

                                          Address c/o Promedix, Inc.
                                              448East Winchester Avenue, Suite
                                               200
                                              Salt Lake City, UT

                                      A-66
<PAGE>

                                   EXHIBIT C

                              AFFILIATES AGREEMENT

                                      A-67
<PAGE>

                          COMPANY AFFILIATE AGREEMENT

   THIS AFFILIATE AGREEMENT is entered into as of September   , 1999 (this
"Agreement"), by and among Chemdex Corporation, a Delaware corporation
("Parent"), Promedix.com, Inc., a Delaware corporation (the "Company"), and
                    ("Affiliate").

                                   RECITALS

   A. Parent, Popcorn Acquisitions Corp., a Delaware corporation and wholly
owned subsidiary of Parent ("Merger Sub"), and the Company have entered into
an Agreement and Plan of Merger dated as of September   , 1999 (the "Merger
Agreement"), providing for the merger of Merger Sub with and into the Company
(the "Merger"). The Merger Agreement contemplates that, upon consummation of
the Merger, (i) the holders of the capital stock of the Company ("Company
Capital Stock") will receive shares of common stock of Parent ("Parent Common
Stock") in exchange for their shares of Company Capital Stock, and (ii) the
Company will become a wholly-owned subsidiary of Parent. It is accordingly
contemplated that Affiliate will receive shares of Parent Common Stock in the
Merger.

   B. Affiliate understands that the Parent Common Stock being issued in the
Merger will be issued pursuant to a registration statement on Form S-4 and
that Affiliate may be deemed to be an "affiliate" of the Company, as the term
"affiliate" is used for purposes of paragraphs (c) and (d) of Rule 145 ("Rule
145") of the General Rules and Regulations of the Securities and Exchange
Commission (the "SEC") under the Securities Act of 1933, as amended (the
"Securities Act"), and as such, Affiliate may only transfer, sell or dispose
of such Parent Common Stock in accordance with this Affiliate Agreement and
Rule 145.

   NOW, THEREFORE, in order to induce Parent to consummate the transactions
contemplated by the Merger Agreement, and for other valuable consideration
(the receipt and sufficiency of which are hereby acknowledged by Affiliate),
Affiliate hereby covenants and agrees as follows:

                                   ARTICLE I

   1. Representations and Warranties of Affiliate. Affiliate represents and
warrants to Parent as follows:

     1.1 Ownership. Affiliate is the holder and "beneficial owner" (as
  defined in Rule 13d-3 under the Securities Exchange Act of 1934, as
  amended) of the number of shares of the Company Capital Stock set forth
  under Affiliate's signature below (the "Company Shares"), and Affiliate has
  good and valid title to the Company Shares, free and clear of any liens,
  pledges, security interests, adverse claims, equities, options, proxies,
  charges, encumbrances or restrictions of any nature.

     1.2 Limitation on Transfer.  Affiliate has carefully read this
  Agreement, and has discussed with Affiliate's own independent counsel to
  the extent Affiliate felt necessary the limitations imposed on Affiliate's
  ability to sell, transfer or otherwise dispose of the shares of Parent
  Common Stock that Affiliate is to receive in the Merger (the "Parent
  Shares"). Affiliate fully understands the limitations this Agreement places
  upon Affiliate's ability to sell, transfer or otherwise dispose of the
  Parent Shares and the Company Shares.

                                  ARTICLE II

   2. Transfer Restrictions.

     2.1 Prohibition Against Transfer. In addition to the restrictions set
  forth elsewhere herein, Affiliate agrees that Affiliate shall not effect
  any sale, transfer or other disposition of the Parent Shares unless:

       (a) such sale, transfer or other disposition is made in conformity
    with the volume and other requirements of Rule 145 under the Securities
    Act;

                                     A-68
<PAGE>

       (b) such sale, transfer or other disposition is effected pursuant to
    an effective registration statement under the Securities Act; or

       (c) an authorized representative of the SEC shall have rendered
    written advice to Affiliate to the effect that the SEC would take no
    action, or that the staff of the SEC would not recommend that the SEC
    take action, with respect to such proposed sale, transfer or other
    disposition, and a copy of such written advice and all other related
    communications with the SEC shall have been delivered to Parent.

     2.2 Stop Transfer Instructions; Legend. Affiliate acknowledges and
  agrees that (a) stop transfer instructions will be given to Parent's
  transfer agent with respect to the Parent Shares, and (b) each certificate
  representing any of such shares of Parent Common Stock or any substitutions
  thereof shall bear a legend (together with any other legend or legends
  required by applicable state securities laws or otherwise), stating in
  substance:

    THE SHARES REPRESENTED BY THIS CERTIFICATE WERE ISSUED IN A TRANSACTION
    TO WHICH RULE 145 PROMULGATED UNDER THE SECURITIES ACT OF 1933 APPLIES.
    THE SHARES REPRESENTED BY THIS CERTIFICATE MAY NOT BE OFFERED, SOLD OR
    OTHERWISE TRANSFERRED, ASSIGNED, PLEDGED OR HYPOTHECATED EXCEPT IN
    ACCORDANCE WITH THE PROVISIONS OF SUCH RULE AND IN ACCORDANCE WITH THE
    TERMS OF AN AGREEMENT DATED AS OF SEPTEMBER   , 1999 BETWEEN THE
    REGISTERED HOLDER HEREOF AND CHEMDEX CORPORATION, A COPY OF WHICH
    AGREEMENT IS ON FILE AT THE PRINCIPAL OFFICES OF CHEMDEX CORPOATION.

                                  ARTICLE III

   3. General Provisions.

     3.1 Specific Performance. The parties agree that irreparable damage
  would occur in the event that any of the provisions of this Agreement were
  not performed in accordance with its specific terms or were otherwise
  breached. Affiliate agrees that, in the event of any breach or threatened
  breach by Affiliate of any covenant or obligation contained in this
  Agreement, each of Parent and the Company shall be entitled (in addition to
  any other remedy that may be available to it, including monetary damages)
  to seek and obtain (a) a decree or order of specific performance to enforce
  the observance and performance of such covenant or obligation, and (b) an
  injunction restraining such breach or threatened breach.

     3.2 Independence of Obligations. The covenants and obligations of
  Affiliate set forth in this Affiliate Agreement shall be construed as
  independent of any other agreement or arrangement between Affiliate, on the
  one hand, and the Company or Parent, on the other. The existence of any
  claim or cause of action by Affiliate against the Company or Parent shall
  not constitute a defense to the enforcement of any of such covenants or
  obligations against Affiliate.

     3.3 Notices. Any notice or other communication required or permitted to
  be delivered under this Agreement shall be in writing and shall be deemed
  properly delivered, given and received when delivered (by hand, by
  registered mail, by courier or express delivery service or by facsimile
  confirmation) to the address or facsimile telephone number set forth
  beneath the name of such party below (or to such other address or facsimile
  telephone number as such party shall have specified in a written notice
  given to the other party):

       If to Parent:  Chemdex Corporation
                        3950 Fabian Way
                        Palo Alto, CA 94308
                        Attention: Chief Executive Officer
                        Telephone No.: (650) 813-0300
                        Telecopy No.: (650) 813-0304

                                      A-69
<PAGE>

  with a copy at the same address to the attention of the General Counsel and
  Secretary and with a copy to:

                        Venture Law Group
                        A Professional Corporation
                        2800 Sand Hill Road
                        Menlo Park, California 94025
                        Attention: Steven J. Tonsfeldt
                        Telephone No.: (650) 854-4488
                        Telecopy No.: (650) 233-8386

       If to Company:  Promedix.com, Inc.
                        448 East Winchester Avenue, Suite 200
                        Salt Lake City, Utah 84107
                        Attention: Chief Executive Officer
                        Telephone No.: (800) 453-1264
                        Telecopy No.: (801) 261-7475

       With a copy to:  Orrick, Herrington & Sutcliffe LLP
                        1020 Marsh Road
                        Menlo Park, CA 94025
                        Attention: Geoffrey P. Leonard, Esq.
                        Telephone No.: (650) 614-7470
                        Telecopy No.: (650) 614-7401

       If to Affiliate:

  at the address or facsimile phone number set forth below Affiliate's
  signature on the signature page hereof.

       With a copy to:


                        Attention:
                        Telephone No.:
                        Telecopy No.:

     3.4 Severability. If any provision of this Agreement or any part of any
  such provision is held under any circumstances to be invalid or
  unenforceable in any jurisdiction, then (a) such provision or part thereof
  shall, with respect to such circumstances and in such jurisdiction, be
  deemed amended to conform to applicable laws so as to be valid and
  enforceable to the fullest possible extent, (b) the invalidity or
  unenforceability of such provision or part thereof under such circumstances
  and in such jurisdiction shall not affect the validity or enforceability of
  such provision or part thereof under any other circumstances or in any
  other jurisdiction, and (c) the invalidity or unenforceability of such
  provision or part thereof shall not affect the validity or enforceability
  of the remainder of such provision or the validity or enforceability of any
  other provision of this Agreement. Each provision of this Agreement is
  separable from every other provision of this Agreement, and each part of
  each provision of this Agreement is separable from every other part of such
  provision.

                                      A-70
<PAGE>

     3.5 Governing Law. This Agreement shall be construed in accordance with,
  and governed in all respects by, the laws of the State of Delaware (without
  giving effect to principles of conflicts of laws).

     3.6 Waiver. No failure on the part of Parent or the Company to exercise
  any power, right, privilege or remedy under this Agreement, and no delay on
  the part of Parent or the Company in exercising any power, right, privilege
  or remedy under this Agreement, shall operate as a waiver of such power,
  right, privilege or remedy; and no single or partial exercise of any such
  power, right, privilege or remedy shall preclude any other or further
  exercise thereof or of any other power, right, privilege or remedy. Neither
  Parent or the Company shall be deemed to have waived any claim arising out
  of this Agreement, or any power, right, privilege or remedy under this
  Agreement, unless the waiver of such claim, power, right, privilege or
  remedy is expressly set forth in a written instrument duly executed and
  delivered on behalf of the party deemed to be charged; and any such waiver
  shall not be applicable or have any effect except in the specific instance
  in which it is given.

     3.7 Captions. The captions contained in this Agreement are for
  convenience of reference only, shall not be deemed to be a part of this
  Agreement and shall not be referred to in connection with the construction
  or interpretation of this Agreement.

     3.8 Further Assurances. Affiliate shall execute and/or cause to be
  delivered to Parent or the Company such instruments and other documents and
  shall take such other actions as Parent or the Company may reasonably
  request to effectuate the intent and purposes of this Agreement.

     3.9 Entire Agreement. This Agreement, the Merger Agreement and any
  Voting Agreement (including any irrevocable proxy contained therein)
  between Affiliate and Parent constitute the entire agreement between the
  parties with respect to the subject matter hereof and thereof and supersede
  all prior agreements and understandings between the parties with respect
  thereto.

     3.10 Non-Exclusivity. The rights and remedies of Parent and the Company
  hereunder are not exclusive of or limited by any other rights or remedies
  which Parent may have, whether at law, in equity, by contract or otherwise,
  all of which shall be cumulative (and not alternative). Nothing in this
  Agreement shall limit any of Affiliate's obligations, or the rights or
  remedies of Parent or the Company, under any Voting Agreement (including
  any irrevocable proxy contained therein) between Parent and Affiliate (to
  the extent that Affiliate shall have entered into such an agreement), and
  nothing in any such Voting Agreement (including any irrevocable proxy
  contained therein) shall limit any of Affiliate's obligations, or any of
  the rights or remedies of Parent, under this Agreement.

     3.11 Amendments. This Agreement may not be amended, modified, altered,
  or supplemented other than by means of a written instrument duly executed
  and delivered on behalf of Parent, the Company and Affiliate.

     3.12 Binding Nature. This Agreement will be binding upon Affiliate and
  Affiliate's representatives, executors, administrators, estate, heirs,
  successors and assigns, and shall inure to the benefit of the Company,
  Parent and their respective successors and assigns.

     3.13 Attorney's Fees and Expenses. If any legal action or other legal
  proceeding relating to the enforcement of any provision of this Agreement
  is brought against Affiliate, the prevailing party shall be entitled to
  recover reasonable attorneys' fees, costs and disbursements (in addition to
  any other relief to which the prevailing party may be entitled).

     3.14 Assignment. This Agreement and all obligations of Affiliate
  hereunder are personal to Affiliate and may not be transferred or delegated
  by Affiliate at any time. The Company or Parent may freely assign any or
  all of its rights under this Affiliate Agreement, in whole or in part to
  any other person or entity without obtaining the consent or approval of
  Affiliate.

     3.15 Survival. Each of the representations, warranties, covenants and
  obligations contained in this Agreement shall survive the consummation of
  the Merger.

                            [Signature Page Follows]

                                      A-71
<PAGE>

   IN WITNESS WHEREOF, the undersigned have executed this Company Affiliate
Agreement as of the date first set forth above.

                                          CHEMDEX CORPORATION

                                          By: _________________________________

                                          Title: ______________________________

                                          PROMEDIX.COM, INC.

                                          By: _________________________________

                                          Title: ______________________________

                                          AFFILIATE: __________________________

                                          Address: ____________________________

                                          _____________________________________

                                          _____________________________________

                                          Facsimile: __________________________

                                          COMPANY STOCK BENEFICIALLY OWNED BY
                                          AFFILIATE:

                                               shares of Common Stock
                                               shares of Common Stock issuable
                                          upon exercise of outstanding options

                      ****COMPANY AFFILIATE AGREEMENT****

                                      A-72
<PAGE>

                                   EXHIBIT D

                          STOCK RESTRICTION AGREEMENT

                                      A-73
<PAGE>

                          STOCK RESTRICTION AGREEMENT

   This Stock Restriction Agreement (the "Agreement") is made as of September
    , 1999 by and between Chemdex Corporation, a Delaware corporation (the
"Company"), and (Name) (the "Stockholder").

                                    RECITALS

   The Company is a party to an Agreement and Plan of Merger (the "Merger
Agreement") with Promedix.com, Inc. ("Promedix") and Popcorn Acquisition
Corporation dated September 21, 1999.

   Stockholder owns (Shares) of the Common Stock of Promedix (the "Promedix
Shares") originally purchased at a purchase price of $     per Promedix Share
(the "Promedix Purchase Price") pursuant to a Stock Purchase Agreement dated
    , 199 . Stockholder will receive (Shares) shares of the Common Stock of the
Company (the "Shares") upon conversion of 25% of the Promedix Shares in
accordance with the Merger Agreement. The Company and the Stockholder recognize
that, in order to provide the proper incentives for working with the Company,
it is necessary and appropriate for the Stockholder to agree to subject the
Shares to a repurchase option in favor of the Company in the event of the
voluntary or involuntary termination of the employment or consulting
relationship of the Stockholder with the Company and to certain other
restrictions on the transfer of the Shares.

                                   AGREEMENT

   In consideration of the foregoing, the parties hereto agree as follows:

   1. Limitations on Transfer. The Stockholder shall not assign, encumber or
dispose of any interest in the Shares while the Shares are subject to the
Repurchase Option (as defined below). After any Shares have been released from
the Repurchase Option, the Stockholder shall not assign, encumber or dispose of
any interest in such Shares except in compliance with the provisions below and
applicable securities laws.

     (a) Repurchase Option.

       (i) In the event of the voluntary or involuntary termination of
    Stockholder's employment or consulting relationship with the Company
    for any reason (including death or disability), with or without cause,
    subject to the severance provisions of that certain letter agreement
    between the Company and Stockholder dated September 21, 1999 and the
    Change of Control Agreement between the Company and Stockholder, the
    Company shall upon the date of such termination (the "Termination
    Date") have an irrevocable, exclusive option (the "Repurchase Option")
    for a period of 90 days from such date to repurchase all or any portion
    of the Shares held by Stockholder as of the Termination Date which have
    not yet been released from the Company's Repurchase Option at the
    "Repurchase Price" (as defined below)

       (ii) Unless the Company notifies Stockholder within 90 days from the
    date of termination of Stockholder's employment or consulting
    relationship that it does not intend to exercise its Repurchase Option
    with respect to some or all of the Shares, the Repurchase Option shall
    be deemed automatically exercised by the Company as of the 90th day
    following such termination, provided that the Company may notify
    Stockholder that it is exercising its Repurchase Option as of a date
    prior to such 90th day. Unless Stockholder is otherwise notified by the
    Company pursuant to the preceding sentence that the Company does not
    intend to exercise its Repurchase Option as to some or all of the
    Shares to which it applies at the time of termination, execution of
    this Agreement by Stockholder constitutes written notice to Stockholder
    of the Company's intention to exercise its Repurchase Option with
    respect to all Shares to which such Repurchase Option applies. The
    Company, at its choice, may satisfy its payment obligation to
    Stockholder with respect to exercise of the Repurchase Option by either
    (A) delivering a check to Stockholder in the amount of the purchase
    price for the

                                      A-74
<PAGE>

    Shares being repurchased, or (B) in the event Stockholder is indebted
    to the Company, canceling an amount of such indebtedness equal to the
    purchase price for the Shares being repurchased, or (C) by a
    combination of (A) and (B) so that the combined payment and
    cancellation of indebtedness equals such purchase price. In the event
    of any deemed automatic exercise of the Repurchase Option pursuant to
    this Section 3(a)(ii) in which Stockholder is indebted to the Company,
    such indebtedness equal to the purchase price of the Shares being
    repurchased shall be deemed automatically canceled as of the 90th day
    following termination of Stockholder's employment or consulting
    relationship unless the Company otherwise satisfies its payment
    obligations. As a result of any repurchase of Shares pursuant to this
    Section 3(a), the Company shall become the legal and beneficial owner
    of the Shares being repurchased and shall have all rights and interest
    therein or related thereto, and the Company shall have the right to
    transfer to its own name the number of Shares being repurchased by the
    Company, without further action by Stockholder.

       (iii) The Shares shall be subject to the Repurchase Option as of the
    closing of the transaction contemplated by the Merger Agreement. 1/24th
    of the Shares shall be released from the Repurchase Option at the end
    of each month following the Vesting Commencement Date (as set forth on
    the signature page to this Agreement), until all Shares are released
    from the Repurchase Option at the end of such 24 month period (provided
    in each case that the Stockholder's employment or consulting
    relationship with the Company has not been terminated prior to the date
    of any such release). Fractional shares shall be rounded to the nearest
    whole share.

       (iv) The Repurchase Price shall be $    per share (adjusted for any
    stock splits, stock dividends and the like), unless Stockholder's
    employment or consulting relationship with the Company is terminated as
    a result of death or disability, in which case the Repurchase Price
    shall be the fair market value of the Company's Common Stock as of the
    date of termination.

       (v) For purposes of this Section 1, the fair market value of one
    share of Common Stock on the date of termination shall mean:

         (A) If the Common Stock is traded on a securities exchange or The
      Nasdaq National Market, the fair market value shall be deemed to be
      the average of the closing prices of the securities on such exchange
      over the five-day trading period ending one day prior to
      termination;

         (B) If the Common Stock is actively traded over-the-counter, the
      value shall be deemed to be the average of the closing bid or sale
      prices (whichever is applicable) over the five-day period ending one
      day prior to termination.

         (C) If the Common Stock is not traded on a securities exchange,
      the Nasdaq National Market or over-the-counter, the fair market
      value shall be at the highest price per share which the Company
      could obtain on the date of calculation from a willing buyer (not a
      current employee or director) for shares of Common Stock sold by the
      Company, from authorized but unissued shares, as determined in good
      faith by the Board of Directors.

     (b) Assignment. The right of the Company to purchase any part of the
  Shares may be assigned in whole or in part to any stockholder or
  stockholders of the Company or other persons or organizations; provided,
  however, that an assignee, other than a corporation that is the parent or a
  100% owned subsidiary of the Company, must pay the Company, upon assignment
  of such right, cash equal to the difference between the repurchase price
  and fair market value, if the repurchase price is less than the fair market
  value of the Shares subject to the assignment.

     (c) Restrictions Binding on Transferees. All transferees of Shares or
  any interest therein will receive and hold such Shares or interest subject
  to the provisions of this Agreement. Any sale or transfer of the Company's
  Shares shall be void unless the provisions of this Agreement are satisfied.

                                      A-75
<PAGE>

     (d) Tax Indemnification.

       (i) The Repurchase Option is intended to protect the value of the
    assets of the Company and Promedix, including their workforce and
    intangible property. The Shares are intended to constitute a part of
    the consideration for the transactions contemplated by the Merger
    Agreement, and not to constitute compensation for services rendered.
    The Company and Stockholder each agrees to treat the Shares consistent
    with the preceding sentence for all federal, state and local tax
    purposes, and to take no position on any tax return inconsistent
    therewith, except to the extent required by law.

       (ii) The Company will indemnify and hold harmless Stockholder, on an
    after-tax basis, from and against any federal, state or local tax
    liability (including, without limitation, franchise, income, or
    employment taxes) that arises from treatment by any taxing authority of
    (A) the receipt of the Shares by Stockholder or (B) the vesting of such
    Shares, as compensation for services rendered by Stockholder. For
    purposes of the preceding sentence, it shall be assumed that such
    compensation was taxed at the highest combined effective marginal
    federal, state and local income tax rates applicable to compensation of
    individuals residing in Utah at the times the income was recognized.

       (iii) The Company's indemnification obligation with respect to the
    compensation income recognized with respect to receipt of the Shares
    pursuant to subsection 1(d)(ii) shall be reduced by the federal, state
    or local income or franchise taxes paid by the Stockholder with respect
    to sales of the Shares prior to the date that such obligation is
    payable, provided that the number of shares of the Company taken into
    account pursuant to this sentence shall not exceed the number of Shares
    received by Stockholder and the per-share amount realized upon each
    such sale shall not exceed the per-share value of the Shares at the
    Effective Time of the Merger. For purposes of the preceding sentence,
    it shall be assumed that all sales of Shares taken into account were
    taxed at the highest combined effective marginal federal, state and
    local income tax rates applicable to sales of capital assets by
    individuals residing in Utah at the times the sales occur and
    Stockholder's tax basis in the Shares sold equaled the basis of the
    Promedix Shares exchanged for the Shares in the Merger rather than the
    fair market value of the Shares on the date(s) such compensation income
    was recognized. Sales of Shares by Stockholder subsequent to the
    Effective Time shall be taken into account pursuant to the foregoing
    provisions in the order in which such sales occur.

   2. Escrow. For purposes of facilitating the enforcement of the provisions of
Section 1(a) above, the Stockholder agrees to deliver the certificate(s) for
the Shares, together with an Assignment Separate from Certificate in the form
attached to this Agreement as Attachment A executed by the Stockholder and by
the Stockholder's spouse (if required for transfer), in blank, to the Secretary
of the Company, or the Secretary's designee, to hold such certificate(s) and
Assignment Separate from Certificate in escrow and to take all such actions and
to effectuate all such transfers and/or releases as are required in accordance
with the terms of this Agreement. The Stockholder hereby acknowledges that the
Secretary of the Company, or the Secretary's designee, is so appointed as the
escrow holder with the foregoing authorities as a material inducement to make
this Agreement and that said appointment is coupled with an interest and is
accordingly irrevocable. The Stockholder agrees that said escrow holder shall
not be liable to any party hereof (or to any other party). The escrow holder
may rely upon any letter, notice or other document executed by any signature
purported to be genuine and may resign at any time. The Stockholder agrees that
if the Secretary of the Company, or the Secretary's designee, resigns as escrow
holder for any or no reason, the Board of Directors of the Company shall have
the power to appoint a successor to serve as escrow holder pursuant to the
terms of this Agreement.

   3. Legends. The certificate or certificates representing the Shares shall be
endorsed with the following legend (as well as any legends required by
applicable state and federal corporate and securities laws):

     "THE SHARES REPRESENTED BY THIS CERTIFICATE MAY BE TRANSFERRED ONLY IN
  ACCORDANCE WITH THE TERMS OF AN AGREEMENT BETWEEN THE COMPANY AND THE
  STOCKHOLDER, A COPY OF WHICH IS ON FILE WITH THE SECRETARY OF THE COMPANY."

                                      A-76
<PAGE>

   When the Repurchase Option has expired or exercised in full, the Shares then
held by the Stockholder will no longer be subject to the foregoing legend.
After such time, and upon the Stockholder's request, a new certificate or
certificates representing the Shares not repurchased shall be issued without
the legend set forth above and delivered to the Stockholder.

   4. No Employment Rights. Nothing in this Agreement shall affect in any
manner whatsoever the right or power of the Company, or a parent or subsidiary
of the Company, to terminate the Stockholder's employment, for any reason, with
or without cause.

   5. Section 83(b) Election. Stockholder agrees that he will execute and file
within 30 days from the Effective Time with the Internal Revenue Service an
election under Section 83(b) (an "83(b) Election") of the Internal Revenue Code
of 1986, as amended (the "Code"), attached hereto as Attachment C, if
Stockholder, acknowledging that he has had the opportunity to seek independent
advice regarding the applicable provisions of the Code and the income tax laws
of any municipality, state or foreign country in which Stockholder may reside,
decides that it is desirable to do so. Stockholder understands that failure to
file such an election in a timely manner may result in adverse tax consequences
for Stockholder. Stockholder further understands that an additional copy of
such election form should be filed with his or her federal income tax return
for the calendar year in which the date of this Agreement falls.

   6. Miscellaneous.

     (a) Governing Law. This Agreement and all acts and transactions pursuant
  hereto and the rights and obligations of the parties hereto shall be
  governed, construed and interpreted in accordance with the laws of the
  State of California, without giving effect to principles of conflicts of
  law.

     (b) Entire Agreement; Enforcement of Rights. This Agreement sets forth
  the entire agreement and understanding of the parties relating to the
  subject matter herein and merges all prior discussions between them. No
  modification of or amendment to this Agreement, nor any waiver of any
  rights under this Agreement, shall be effective unless in writing signed by
  the parties to this Agreement. The failure by either party to enforce any
  rights under this Agreement shall not be construed as a waiver of any
  rights of such party.

     (c) Severability. If one or more provisions of this Agreement are held
  to be unenforceable under applicable law, the parties agree to renegotiate
  such provision in good faith. In the event that the parties cannot reach a
  mutually agreeable and enforceable replacement for such provision, then (i)
  such provision shall be excluded from this Agreement, (ii) the balance of
  the Agreement shall be interpreted as if such provision were so excluded
  and (iii) the balance of the Agreement shall be enforceable in accordance
  with its terms.

     (d) Construction. This Agreement is the result of negotiations between
  and has been reviewed by each of the parties hereto and their respective
  counsel, if any; accordingly, this Agreement shall be deemed to be the
  product of all of the parties hereto, and no ambiguity shall be construed
  in favor of or against any one of the parties hereto.

     (e)  Notices. Any notice required or permitted by this Agreement shall
  be in writing and shall be deemed sufficient upon delivery, when delivered
  personally or by overnight courier or sent by telegram or fax, or 48 hours
  after being deposited in the U.S. mail, as certified or registered mail,
  with postage prepaid, and addressed to the party to be notified at such
  party's address as set forth below or as subsequently modified by written
  notice.

     (f) Counterparts. This Agreement may be executed in two or more
  counterparts, each of which shall be deemed an original and all of which
  together shall constitute one instrument.

     (g) Successors and Assigns. The rights and benefits of this Agreement
  shall inure to the benefit of, and be enforceable by the Company's
  successors and assigns. The rights and obligations of the Stockholder under
  this Agreement may only be assigned with the prior written consent of the
  Company.

                            [Signature Page Follows]

                                      A-77
<PAGE>

   The parties hereto have executed this Agreement as of the day and year first
set forth above.

                                          CHEMDEX CORPORATION

                                          By: _________________________________
                                           David P. Perry
                                           President

                                           Address:
                                           3950 Fabian Way
                                           Palo Alto, CA 94303

   THE STOCKHOLDER ACKNOWLEDGES AND AGREES THAT THE VESTING OF SHARES PURSUANT
TO SECTION 1 HEREOF IS EARNED ONLY BY CONTINUING SERVICE AS AN EMPLOYEE OR
CONSULTANT AT THE WILL OF THE COMPANY. THE STOCKHOLDER FURTHER ACKNOWLEDGES AND
AGREES THAT NOTHING IN THIS AGREEMENT SHALL CONFER UPON THE STOCKHOLDER ANY
RIGHT WITH RESPECT TO CONTINUATION OF SUCH EMPLOYMENT OR CONSULTING
RELATIONSHIP WITH THE COMPANY, NOR SHALL IT INTERFERE IN ANY WAY WITH THE
STOCKHOLDER'S RIGHT OR THE COMPANY'S RIGHT TO TERMINATE THE STOCKHOLDER'S
EMPLOYMENT OR CONSULTING RELATIONSHIP AT ANY TIME, WITH OR WITHOUT CAUSE.

                                          THE STOCKHOLDER:

                                          (Name)
                                          _____________________________________

                                          Address:
                                          (Address1)
                                          (Address2)

Vesting Commencement Date:


                                      A-78
<PAGE>

                                  ATTACHMENT A

                      ASSIGNMENT SEPARATE FROM CERTIFICATE

   FOR VALUE RECEIVED and pursuant to that certain Stock Restriction Agreement
between the undersigned (the "Stockholder") and Chemdex Corporation (the
"Company") dated May     , 1998 (the "Agreement"), the Stockholder hereby
sells, assigns and transfers unto the Company        shares of the Company's
Common Stock standing in the Stockholder's name on the books of said
corporation represented by Certificate No.        herewith and does hereby
irrevocably constitute and appoint        to transfer said stock on the books
of the Company with full power of substitution in the premises. THIS ASSIGNMENT
MAY ONLY BE USED AS AUTHORIZED BY THE AGREEMENT AND THE ATTACHMENTS THERETO.

Dated:       ,      .

                                          Signature:

                                          _____________________________________
                                          (Name)

                                          _____________________________________
                                          Spouse of (Name)

Instruction: Please do not fill in any blanks other than the signature line.
The purpose of this assignment is to enable the Company to exercise the
Repurchase Option set forth in the Agreement without requiring additional
signatures on the part of the Stockholder.

                                      A-79
<PAGE>

                                  ATTACHMENT B

                               CONSENT OF SPOUSE

   I,      , spouse of (Name), have read and hereby approve the foregoing Stock
Restriction Agreement (the "Agreement"). In consideration of the Company's
enhanced potential to raise additional capital for the benefit of all
stockholders, including my spouse, provided by the Agreement, I hereby agree to
be irrevocably bound by the Agreement and further agree that any community
property or other interest I may have in the Shares shall be subject to the
Agreement. I hereby appoint my spouse as my attorney-in-fact with respect to
any amendment to or exercise of any rights I may have under the Agreement.

                                          _____________________________________
                                          Spouse of (Name)

                                      A-80
<PAGE>

                                  ATTACHMENT C

                          ELECTION UNDER SECTION 83(b)
                      OF THE INTERNAL REVENUE CODE OF 1986

   The undersigned taxpayer hereby elects, pursuant to Section 83(b) of the
Internal Revenue Code, to include in taxpayer's gross income for the current
taxable year, the amount of any compensation taxable to taxpayer in connection
with taxpayer's receipt of the property described below:

  1. The name, address, taxpayer identification number and taxable year of
     the undersigned are as follows:

     NAME OF TAXPAYER:  (Name)

     NAME OF SPOUSE:

      ADDRESS:  (Address1)

                  (Address2)

     IDENTIFICATION NO. OF TAXPAYER:

     IDENTIFICATION NO. OF SPOUSE:

     TAXABLE YEAR:

  2. The property with respect to which the election is made is described as
     follows:

               shares of the Common Stock $0.0001 par value, of Chemdex
     Corporation, a Delaware corporation (the "Company").

  3.  The date on which the property was transferred is:

  4.  The property is subject to the following restrictions:

     Repurchase option at cost in favor of the Company upon termination of
     taxpayer's employment or consulting relationship.

  5.  The fair market value at the time of transfer, determined without
      regard to any restriction other than a restriction which by its terms
      will never lapse, of such property is: $

    6.  The amount (if any) paid for such property: $

   The undersigned has submitted a copy of this statement to the person for
whom the services were performed in connection with the undersigned's receipt
of the above-described property. The transferee of such property is the person
performing the services in connection with the transfer of said property.

   The undersigned understands that the foregoing election may not be revoked
except with the consent of the (Commissioner.

Dated:
                                          _____________________________________
                                          (Name)
Dated:
                                          _____________________________________

                                      A-81
<PAGE>

                                   EXHIBIT E

                                ESCROW AGREEMENT

                                      A-82
<PAGE>

                                ESCROW AGREEMENT

   THIS ESCROW AGREEMENT (this "Agreement") is entered into as of September   ,
1999, by and among Chemdex Corporation, a Delaware corporation ("Chemdex"),
Promedix.com, Inc., a Delaware corporation ("Promedix"), U.S. Bank Trust,
National Association, as Escrow Agent ("Escrow Agent"), and Skip Klintworth and
Brad Bond, as Stockholders' Agents ("Stockholders' Agents") with respect to the
shares of Chemdex capital stock to be issued to the former Promedix
Stockholders (collectively, the "Holders") in the Merger (as defined below).

                                    RECITALS

   A. Chemdex, Promedix, and Promedix Acquisition Corp., a Delaware corporation
and wholly-owned subsidiary of Chemdex ("Sub"), have entered into a Agreement
and Plan of Merger dated as of September 21, 1999 (the "Merger Agreement"),
pursuant to which Sub will merge with and into Promedix (the "Merger"), with
Promedix surviving the Merger as the surviving corporation. Capitalized terms
used in this Agreement and not otherwise defined in this Agreement shall have
the meanings given them in the Merger Agreement.

   B. Section 2.2 of the Merger Agreement provides that at the Effective Time,
or such later time as determined in accordance with Section 2.3(b) of the
Merger Agreement with respect to Dissenting Shares for which dissenters' rights
shall have been withdrawn or lost, Chemdex will deposit in escrow (such deposit
constituting the "Escrow Fund") certificates representing an aggregate of
12,057,366 shares of Chemdex Common Stock issuable to the Holders in the
Merger, on a pro rata basis, in accordance with each Holder's percentage
ownership of Chemdex Common Stock issuable pursuant to the Merger. Pursuant to
the Merger Agreement, (i) ninety percent (90%) of such shares (the "Locked Up
Shares") shall be held in escrow on behalf of the holders until January 22,
2000, but not held as security for Promedix's indemnification obligations under
Article X of the Merger Agreement; and (ii) ten percent (10%) of such shares
(the "Escrow Shares") shall be held as security for Promedix's indemnification
obligations under Article X of the Merger Agreement and shall represent
Chemdex's sole and exclusive remedy with respect to such indemnification
obligations, except for damages based upon a claim of fraud. The Locked Up
Shares and Escrow Shares are collectively referred to herein as the "Escrow
Securities."

   C. The parties to this Agreement desire to establish the terms and
conditions pursuant to which the Escrow Securities will be deposited, held in,
and disbursed from the Escrow Fund.

                                   AGREEMENT

   NOW, THEREFORE, the parties to this Agreement agree as follows:

     1. Escrow Fund. The Escrow Agent agrees to: (a) accept delivery of the
  Escrow Securities; and (b) hold such Escrow Securities in escrow as part of
  the Escrow Fund, all subject to the terms and conditions of this Agreement
  and Section 2.2 and Article X of the Merger Agreement (which Section 2.2
  and Article X are attached to this Agreement as Appendix I and incorporated
  by reference into this Agreement) (collectively, the "Escrow Provisions").
  The Escrow Securities will include "Additional Escrow Securities" as that
  term is defined in Section 2(c) of this Agreement.

     2. Deposit of Escrow Securities: Release from Escrow.

       (a) Delivery of Escrow Securities. As soon as practicable after the
    Effective Time, the Escrow Securities will be delivered by Chemdex on
    behalf of the Holders to the Escrow Agent. Such shares shall be issued
    in the name of the Escrow Agent. In the event Chemdex issues any
    Additional Escrow Securities, such Escrow Securities will be issued in
    the name of the Escrow Agent and delivered to the Escrow Agent in the
    same manner as the Escrow Securities.


                                      A-83
<PAGE>

       (b) Holders' Accounts. The Escrow Agent will maintain for each
    Holder an accounting record (each Holder's "Account") specifying the
    Escrow Securities held for the record of each Holder pursuant to the
    Escrow Provisions. All Escrow Securities received under Section 2(a)
    will be allocated to each Holder's Account in accordance with such
    Holder's percentage interest in the Escrow Fund as set forth on
    Appendix II.

       (c) Dividends, Voting and Rights of Ownership. Except for tax-free
    dividends paid in stock declared with respect to the Escrow Securities
    pursuant to Section 305(a) of the Internal Revenue Code of 1986, as
    amended (the "Code") ("Additional Escrow Securities"), there will be
    distributed promptly to the Holders any cash dividends or dividends
    payable in securities or other distributions of any kind made in
    respect of the Escrow Securities. Each Holder will have voting rights
    with respect to the Escrow Securities deposited in the Escrow Fund with
    respect to such Holder so long as such Escrow Securities are held in
    escrow, and Chemdex will take all reasonable steps necessary to allow
    the exercise of such rights. While the Escrow Securities remain in the
    Escrow Agent's possession pursuant to this Agreement and the Merger
    Agreement, the Holders will retain and will be able to exercise all
    other incidents of ownership of said Escrow Securities which are not
    inconsistent with the terms and conditions of this Agreement and the
    Merger Agreement.

       (d) Release. The Locked Up Shares will be held by the Escrow Agent
    until January 22, 2000. The Locked Up Shares shall not be subject to,
    or held as security for, Promedix's indemnification obligations under
    Article X of the Merger Agreement. The Escrow Shares will be held by
    the Escrow Agent until required to be released to the Holders pursuant
    to Section 10.3 of the Merger Agreement, unless previously delivered to
    Chemdex pursuant to Section 10.4 of the Merger Agreement. Within five
    (5) business days after the applicable release condition is met, the
    Escrow Agent will deliver to each Holder the Escrow Securities to be
    released on such date as identified by Chemdex and the Stockholders'
    Agents to the Escrow Agent in writing. Escrow Securities will be in the
    form of stock certificate(s) issued in the name of such Holder. Chemdex
    and the Stockholders' Agents will undertake to deliver a notice to the
    Escrow Agent identifying the number of Escrow Securities to be released
    with respect to each Holder within such five-day period. Escrow
    Securities will be released to the respective Holders in accordance
    with their respective Accounts. Chemdex will take such action as may be
    necessary to cause such certificates to be issued in the names of the
    appropriate Holders. Cash will be paid in lieu of fractions of Escrow
    Securities in an amount equal to the product determined by multiplying
    such fraction by $        (the "Per Share Value"). Within five (5)
    business days after written request from the Stockholders' Agents,
    Chemdex will deposit with the Escrow Agent sufficient funds to pay such
    cash amounts for fractional shares.

       (e) No Encumbrance. Except as provided in this Agreement and as may
    be set forth in the Target Disclosure Schedule, no Escrow Securities or
    any beneficial interest in the Escrow Securities may be pledged, sold,
    assigned or transferred, including by operation of law, by a Holder or
    be taken or reached by any legal or equitable process in satisfaction
    of any debt or other liability of a Holder, prior to the delivery to
    such Holder of the Escrow Securities by the Escrow Agent.

       (f) Power to Transfer Escrow Securities. The Escrow Agent is granted
    the power to effect any transfer of Escrow Securities contemplated by
    the Escrow Provisions. Chemdex will cooperate with the Escrow Agent in
    promptly issuing stock certificates to effect such transfers.

       (g) Reporting. Each Holder will provide the Escrow Agent with
    his/her/its Taxpayer Identification Number at or prior to Closing. On
    or before January 31 of each year under this Agreement, the Escrow
    Agent will prepare and mail to each Holder, other than Holders who
    demonstrate their status as non-resident aliens in accordance with the
    United States Treasury Regulations, a Form 1099-B reporting any cash
    payments, in accordance with such Treasury Regulations. The Escrow
    Agent will also prepare and file copies of such Forms 1099-B by
    magnetic tape with the IRS, in accordance with Treasury Regulations. If
    the Escrow Agent has not received notice from a Holder of such Holder's
    certified Taxpayer Identification Number, the Escrow Agent

                                      A-84
<PAGE>

    shall deduct and withhold backup withholding tax from any cash payment
    made pursuant to the Internal Revenue Code and applicable regulations
    thereunder. Should any issue arise regarding federal income tax
    reporting or withholding, the Escrow Agent shall act in accordance with
    the written instructions of the Stockholders' Agents and Chemdex.

     3. Limitation of the Escrow Agent's Liability.

       (a) The Escrow Agent will incur no liability with respect to any
    action taken or suffered by it in reliance upon any notice, direction,
    instruction, consent, statement or other document believed by it to be
    genuine and duly authorized, nor for any other action or inaction,
    except its own willful misconduct, bad faith or gross negligence. The
    Escrow Agent will not be responsible for the validity or sufficiency of
    the Escrow Provisions. In all questions arising under the Escrow
    Provisions, the Escrow Agent may rely on the advice of counsel, and for
    anything done, omitted or suffered in good faith by the Escrow Agent
    based on such advice, the Escrow Agent will not be liable to anyone.
    The Escrow Agent will not be required to take any action under the
    Escrow Provisions involving any expense unless the payment of such
    expense is made or provided for in a manner satisfactory to it.

       (b) In the event conflicting demands are made or notices are served
    upon the Escrow Agent with respect to the Escrow Fund, the Escrow Agent
    will have the absolute right, at the Escrow Agent's election, to do
    either or both of the following: resign so a successor can be appointed
    pursuant to Section 5 or file a suit in interpleader and obtain an
    order from a court of competent jurisdiction requiring the parties to
    interplead and litigate in such court their several claims and rights
    among themselves. In the event such interpleader suit is brought, the
    Escrow Agent will thereby be fully released and discharged from all
    further obligations imposed upon it under the Escrow Provisions, and
    Chemdex will pay the Escrow Agent (subject to reimbursement from the
    Holders pursuant to Section 4) all costs, expenses and reasonable
    attorney's fees expended or incurred by the Escrow Agent pursuant to
    the exercise of the Escrow Agent's rights under this Section 3 (such
    costs, fees and expenses will be treated as extraordinary fees and
    expenses for the purposes of Section 4).

     4. Expenses.

       (a) Escrow Agent. All fees and expenses of the Escrow Agent incurred
    in the ordinary course of performing its responsibilities hereunder
    will be paid by Chemdex upon receipt of a written invoice by the Escrow
    Agent. Any extraordinary fees and expenses, including without
    limitation any fees or expenses incurred by the Escrow Agent in
    connection with a dispute over the distribution of Escrow Securities or
    the validity of a claim or claims by Chemdex made in an Officer's
    Certificate, will be paid 50% by Chemdex and 50% by the Holders. The
    Holders' liability for the extraordinary fees and expenses of the
    Escrow Agent may be paid by Chemdex and recovered as a claim hereunder
    out of the Escrow Fund. If Chemdex has paid the Holders' portion of
    such fees and expenses as permitted under this Section 4(a), then the
    Escrow Agent will, upon demand by Chemdex, transfer to Chemdex a number
    of Escrow Securities having an aggregate Per Share Value equal to such
    portion of fees and expenses.

       In the event the balance in the Escrow Fund is not sufficient to pay
    the extraordinary fees and expenses of the Escrow Agent, as described
    in the prior paragraph, or in the event the Escrow Agent incurs any
    liability to any person, firm or corporation by reason of its
    acceptance or administration of this Escrow Agreement, the other
    parties hereto, jointly and severally, agree to indemnify the Escrow
    Agent for its extraordinary fees and expenses or costs and expenses,
    including, without limitation, counsel fees and expenses, as the case
    may be. Notwithstanding the foregoing, no indemnity need be paid in the
    event of the Escrow Agent's gross negligence, bad faith or willful
    misconduct.

       (b) Stockholders' Agents. The Stockholders' Agents will not be
    entitled to receive any compensation from Chemdex or the Holders in
    connection with this Agreement. Any fees and expenses incurred by the
    Stockholders' Agents in connection with actions taken pursuant to the
    terms of the Escrow Provisions will be paid by the Holders.

                                      A-85
<PAGE>

     5. Successor Escrow Agent. In the event the Escrow Agent becomes
  unavailable or unwilling to continue in its capacity as such, the Escrow
  Agent may resign and be discharged from its duties or obligations hereunder
  by giving resignation to the parties to this Agreement, specifying not less
  than thirty (30) days' prior written notice of such a date when such
  resignation will take effect. Chemdex will designate a successor Escrow
  Agent prior to the expiration of such 30-day period by giving written
  notice to the Escrow Agent and the Stockholders' Agents. Chemdex may
  appoint a successor Escrow Agent with the consent of the Stockholders'
  Agents, which will not be unreasonably withheld. The Escrow Agent will
  promptly transfer the Escrow Securities to such designated successor. In
  the event no successor Escrow Agent is appointed as described in this
  Section 5, the Escrow Agent may apply to a court of competent jurisdiction
  for the appointment of a successor Escrow Agent.

     6. Limitation of Responsibility. The Escrow Agent's duties are limited
  to those set forth in the Escrow Provisions and the Escrow Agent may rely
  upon the written notices delivered to the Escrow Agent under the Escrow
  Provisions.

     7. Incorporation by Reference of Article X. The parties agree that the
  terms of Section 2.2 and Article X of the Merger Agreement shall be deemed
  to be incorporated by reference in this Agreement as if such Article had
  been set forth in its entirety herein. The parties acknowledge that the
  administration of the Escrow Fund by the Escrow Agent will require
  reference to both the terms of this Agreement as well as the terms of such
  Article X.

     8. Notices. Any notice provided for or permitted under the Escrow
  Provisions will be treated as having been given when (i) delivered
  personally, (ii) sent by confirmed telex or Fax, (iii) sent by commercial
  overnight courier with written verification of receipt, or (iv) mailed
  postage prepaid by certified or registered mail, return receipt requested,
  to the party to be notified, at the address set forth below, or at such
  other place of which the other party has been notified in accordance with
  the provisions of this Section 8.

     Escrow Agent:      U.S. Bank Trust, National Association
                        One California Street, 4th Floor
                        San Francisco, California 94111
                        Attention: Ann Gadsby
                        Fax No: (415) 273-4593
                        Telephone No: (415) 273-4532
     Stockholders' Agents:
                        Promedix, Inc.
                        448 East Winchester Avenue, Suite 200
                        Salt Lake City, Utah 84107
                        Attention: Skip Klintworth
                        Brad Bond
                        Fax No: (801) 261-7475
                        Telephone No: (800) 453-1264

     With copy to:      Orrick, Herrington & Sutcliffe LLP
                        1020 Marsh Road
                        Menlo Park, CA 94025
                        Attention: Geoffrey P. Leonard, Esq.
                        Fax No: (650) 614-7401
                        Telephone No: (650) 614-7470

     Chemdex:           Chemdex Corporation
                        3950 Fabian Way
                        Palo Alto, CA 94308
                        Attention: Chief Executive Officer
                        Fax No: (650) 813-0304
                        Telephone No: (650) 813-0300

                                      A-86
<PAGE>

     With copy to:      Venture Law Group
                        A Professional Corporation
                        2775 Sand Hill Road
                        Menlo Park, California 94025
                        Attention: Jeffrey Y. Suto
                        Fax No: (650) 233-8386
                        Telephone No: (650) 854-4488

   Such notice will be treated as having been received upon actual receipt.

     9. General.

       (a) Governing Laws. It is the intention of the parties hereto that
    the internal laws of the State of Delaware (irrespective of its choice
    of law principles) shall govern the validity of this Agreement, the
    construction of its terms, and the interpretation and enforcement of
    the rights and duties of the parties to this Agreement.

       (b) Binding upon Successors and Assigns. Subject to, and unless
    otherwise provided in, this Agreement, each and all of the covenants,
    terms, provisions, and agreements contained in this Agreement shall be
    binding upon, and inure to the benefit of, the permitted successors,
    executors, heirs, representatives, administrators and assigns of the
    parties to this Agreement.

       (c) Counterparts. This Agreement may be executed in any number of
    counterparts, each of which shall be an original as against any party
    whose signature appears on such counterpart and all of which together
    shall constitute one and the same instrument. This Agreement shall
    become binding when one or more counterparts of this Agreement,
    individually or taken together, shall bear the signatures of all of the
    parties reflected in this Agreement as signatories.

       (d) Entire Agreement. Except as set forth in the Merger Agreement,
    this Agreement, the documents referenced in this Agreement and the
    exhibits to such documents, constitute the entire understanding and
    agreement of the parties to this Agreement with respect to the subject
    matter of this Agreement and of such documents and exhibits and
    supersede all prior and contemporaneous agreements or understandings,
    inducements or conditions, express or implied, written or oral, between
    the parties with respect to this Agreement. The express terms of this
    Agreement control and supersede any course of performance or usage of
    the trade inconsistent with any of the terms of this Agreement.

       (e) Waivers. No waiver by any party to this Agreement of any
    condition or of any breach of any provision of this Agreement will be
    effective unless in writing. No waiver by any party of any such
    condition or breach, in any one instance, will be deemed to be a
    further or continuing waiver of any such condition or breach or a
    waiver of any other condition or breach of any other provision
    contained in this Agreement.

       (f) Amendment. This Agreement may be amended with the written
    consent of Chemdex, the Escrow Agent and the Stockholders' Agents;
    provided, however, that if the Escrow Agent does not agree to an
    amendment agreed upon by Chemdex and the Stockholders' Agents, a
    successor Escrow Agent will be appointed in accordance with Section 5.

                            [Signature Page Follows]

                                      A-87
<PAGE>

   IN WITNESS WHEREOF, the parties have duly executed this Escrow Agreement as
of the day and year first written above and will be effective as to all the
Holders when executed by Chemdex, the Escrow Agent and the Stockholders'
Agents.

                                          CHEMDEX CORPORATION

                                          By: _________________________________

                                          Its: ________________________________

                                          PROMEDIX.COM, INC.

                                          By: _________________________________

                                          Its: ________________________________

                                          ESCROW AGENT:

                                          U.S. BANK TRUST, NATIONAL
                                           ASSOCIATION

                                          By: _________________________________

                                          Its: ________________________________

                                          STOCKHOLDERS' AGENTS:

                                          _____________________________________
                                          Skip Klintworth

                                          _____________________________________
                                          Brad Bond


                                      A-88
<PAGE>

                                   APPENDIX I

                 Section 2.2 and Article X of Merger Agreement

                                      A-89
<PAGE>

   Section 2.2 Escrow Agreementt. At the Effective Time or such later time as
determined in accordance with Section 2.3(b), Chemdex will, on behalf of the
holders of Promedix Common Stock and Promedix Preferred Stock, deposit in
escrow certificates representing the percentage of the Total Consideration
Shares set forth below allocable to Promedix Common Stock and Promedix
Preferred Stock in the Merger. Such shares shall be held in escrow on behalf of
the persons who are the holders of Promedix Common Stock or Promedix Preferred
Stock in the Merger immediately prior to the Effective Time (the "Former
Promedix Stockholders"), in accordance with the portion of Total Consideration
Shares allocable to each such Former Promedix Stockholder in the manner
contemplated by Section 2.1 ("Pro Rata Portion"). If the Closing shall occur
prior to January 22, 2000, then ninety percent (90%) of such shares
(collectively, the "Locked Up Shares") shall be held in escrow on behalf of the
former Promedix Stockholders until January 22, 2000, after which the
certificates representing the Locked Up Shares will be distributed to the
Former Promedix Stockholders. The Locked Up Shares shall not be subject to
Article X of this Agreement. Ten percent (10%) of such shares (collectively,
the "Escrow Shares") shall be held in escrow and applied pursuant to the
provisions of an escrow agreement (the "Escrow Agreement") to be executed
pursuant to Section 7.6. All calculations to determine the number of Locked Up
Shares and Escrow Shares to be delivered by each stockholder of Promedix into
escrow as aforesaid shall be rounded down to the nearest whole share.

                                   ARTICLE X

                           ESCROW AND INDEMNIFICATION

   Section 10.1 Indemnification. From and after the Effective Time and subject
to the limitations contained in Section 10.2, the Former Promedix Stockholders
will, severally and pro rata, in accordance with their Pro Rata Portion,
indemnify and hold Chemdex harmless against any loss, expense, liability or
other damage, including attorneys' fees, to the extent of the amount of such
loss, expense, liability or other damage (collectively "Damages") that Chemdex
has incurred by reason of the breach by Promedix of any representation,
warranty, covenant or agreement of Promedix contained in this Agreement that
occurs or becomes known to Chemdex during the Escrow Period (as defined in
Section 10.3 below) in excess of $150,000. Chemdex, Promedix and Sub
acknowledge and agree, and the Former Promedix Stockholders, by their approval
of this Agreement and their execution of the Voting Agreements, agree that
notwithstanding anything to the contrary contained in this Agreement or any
other Transaction Document, such indemnification under this Article X shall be
the sole and exclusive remedy for any such claim of breach by Promedix, except
for Damages based upon a claim of fraud.

   Section 10.2 Escrow Fund. As security and the sole and exclusive recourse
for the indemnities in Section 10.1, as soon as practicable after the Effective
Time, the Escrow Shares shall be deposited with U.S. Bank Trust, National
Association (or such other institution selected by Chemdex with the reasonable
consent of Promedix) as escrow agent (the "Escrow Agent"), such deposit to
constitute the Escrow Fund (the "Escrow Fund") and to be governed by the terms
set forth in this Article X and in the Escrow Agreement. Notwithstanding the
foregoing or anything to the contrary contained in this Agreement or in any
Transaction Document, the indemnification obligations of the Former Promedix
Stockholders pursuant to this Article X or otherwise shall be limited to the
amount and assets deposited and present in the Escrow Fund and Chemdex shall
not be entitled to pursue any claims for indemnification under this Article X
or otherwise against the Former Promedix Stockholders directly or personally,
and the sole recourse of Chemdex shall be to make claims against the Escrow
Fund in accordance with the terms of the Escrow Agreement.

   Section 10.3 Escrow Periods. The Escrow Fund shall terminate upon the first
anniversary date of the Closing Date (the period from the Closing Date to such
date referred to as the "Escrow Period"), provided, however, that the number of
Escrow Shares, which, in the reasonable judgment of Chemdex, subject to the
objection of the Stockholders' Agents and the subsequent resolution of the
matter in the manner provided in Section 10.7, are necessary to satisfy any
unsatisfied claims specified in any Officer's Certificate theretofore

                                      A-90
<PAGE>

delivered to the Escrow Agent and the Stockholders' Agents prior to termination
of the Escrow Period with respect to Damages incurred or litigation pending
prior to expiration of the Escrow Period, shall remain in the Escrow Fund until
such claims have been finally resolved.

   Section 10.4 Claims Upon Escrow Fund. Upon receipt by the Escrow Agent on or
before the last day of the Escrow Period of a certificate signed by any
appropriately authorized officer of Chemdex (an "Officer's Certificate"):

     (i) Stating the aggregate amount of Chemdex's Damages or an estimate
  thereof, in each case to the extent known or determinable at such time; and

     (ii) Specifying in reasonable detail the individual items of such
  Damages included in the amount so stated, the date each such item was paid
  or properly accrued or arose, and the nature of the misrepresentation,
  breach or claim to which such item is related, the Escrow Agent shall,
  subject to the provisions of Sections 10.3 and 10.7 hereof and of the
  Escrow Agreement, deliver to Chemdex out of the Escrow Fund, as promptly as
  practicable, Escrow Shares having a value equal to such Damages all in
  accordance with the Escrow Agreement and Section 10.5 below. Amounts paid
  or distributed from the Escrow Fund shall be paid or distributed pro rata
  among the Holders (as defined in the Escrow Agreement) based upon their
  respective percentage interests therein at the time.

   Section 10.5 Valuation. For the purpose of compensating Chemdex for its
Damages pursuant to this Agreement, the value per share of the Escrow Shares
which shall be released to Chemdex in respect of a claim for Damages shall be
the Average Stock Price (as appropriately adjusted for stock splits,
recapitalizations and the like).

   Section 10.6 Objections to Claims. At the time of delivery of any Officer's
Certificate to the Escrow Agent, a duplicate copy of such Officer's Certificate
shall be delivered to the Stockholders' Agents (as defined in Section 10.8
below) and for a period of thirty (30) days after such delivery, the Escrow
Agent shall make no delivery of Escrow Shares pursuant to Section 10.3 unless
the Escrow Agent shall have received written authorization from the
Stockholders' Agents to make such delivery. After the expiration of such thirty
(30) day period, the Escrow Agent shall make delivery of the Escrow Shares in
the Escrow Fund in accordance with Section 10.3, provided that no such delivery
may be made if the Stockholders' Agents shall object in a written statement to
the claim made in the Officer's Certificate, and such statement shall have been
delivered to the Escrow Agent and to Chemdex prior to the expiration of such
thirty (30) day period.

   Section 10.7 Resolution of Conflicts.

     (a) In case the Stockholders' Agents shall so object in writing to any
  claim or claims by Chemdex made in any Officer's Certificate, Chemdex shall
  have thirty (30) days to respond in a written statement to the objection of
  the Stockholders' Agents. If after such thirty (30) day period there
  remains a dispute as to any claims, the Stockholders' Agents and Chemdex
  shall attempt in good faith for thirty (30) days to agree upon the rights
  of the respective parties with respect to each of such claims. If the
  Stockholders' Agents and Chemdex should so agree, a memorandum setting
  forth such agreement shall be prepared and signed by both parties and shall
  be furnished to the Escrow Agent. The Escrow Agent shall be entitled to
  rely on any such memorandum and shall distribute the Escrow Shares from the
  Escrow Fund in accordance with the terms of the memorandum.

     (b) If no such agreement can be reached after good faith negotiation,
  either Chemdex or the Stockholders' Agents may, by written notice to the
  other, demand arbitration of the matter unless the amount of the damage or
  loss is at issue in pending litigation with a third party, in which event
  arbitration shall not be commenced until such amount is ascertained or both
  parties agree to arbitration; and in either such event the matter shall be
  settled by arbitration conducted by three arbitrators. Within fifteen (15)
  days after such written notice is sent, Chemdex (on the one hand) and the
  Stockholders' Agents (on the other

                                      A-91
<PAGE>

  hand) shall each select one arbitrator, and the two arbitrators so selected
  shall select a third arbitrator. The decision of the arbitrators as to the
  validity and amount of any claim in such Officer's Certificate shall be
  binding and conclusive upon the parties to this Agreement, and
  notwithstanding anything in Section 10.3, the Escrow Agent shall be
  entitled to act in accordance with such decision and make or withhold
  payments out of the Escrow Fund in accordance with such decision.

     (c) Judgment upon any award rendered by the arbitrators may be entered
  in any court having jurisdiction. Any such arbitration shall be held in
  Santa Clara County, California under the commercial rules then in effect of
  the American Arbitration Association. The non-prevailing party to an
  arbitration shall pay its own expenses, the fees of each arbitrator, the
  administrative fee of the American Arbitration Association, and the
  expenses, including, without limitation, the reasonable attorneys' fees and
  costs, incurred by the prevailing party to the arbitration.

   Section 10.8 Stockholders' Agents.

     (a) Skip Klintworth and Brad Bond shall be constituted and appointed as
  agents (the "Stockholders' Agents") for and on behalf of the Former
  Promedix Stockholders to give and receive notices and communications, to
  authorize delivery to Chemdex of the Escrow Shares or other property from
  the Escrow Fund in satisfaction of claims by Chemdex, to object to such
  deliveries, to agree to, negotiate, enter into settlements and compromises
  of, and demand arbitration and comply with orders of courts and awards of
  arbitrators with respect to such claims, and to take all actions necessary
  or appropriate in the judgment of the Stockholders' Agents for the
  accomplishment of the foregoing. All actions of the Stockholders' Agents
  shall be taken jointly, not individually. Such agency may be changed by the
  holders of a majority in interest of the Escrow Shares from time to time
  upon not less than ten (10) days' prior written notice to Chemdex. No bond
  shall be required of the Stockholders' Agents, and the Stockholders' Agents
  shall receive no compensation for services. Notices or communications to or
  from the Stockholders' Agents shall constitute notice to or from each of
  the Former Promedix Stockholders.

     (b) The Stockholders' Agents shall not be liable for any act done or
  omitted hereunder as Stockholders' Agent while acting in good faith, and
  any act done or omitted pursuant to the advice of counsel shall be
  conclusive evidence of such good faith. The Former Promedix Stockholders
  shall severally and pro rata, in accordance with their Pro Rata Portion,
  indemnify the Stockholders' Agents and hold them harmless against any loss,
  liability or expense incurred without gross negligence or bad faith on the
  part of the Stockholders' Agents and arising out of or in connection with
  the acceptance or administration of their duties hereunder under this
  Agreement or the Escrow Agreement.

     (c) The Stockholders' Agents shall have reasonable access to information
  about Promedix and Chemdex and the reasonable assistance of Promedix's and
  Chemdex's officers and employees for purposes of performing their duties
  and exercising their rights under this Article X, provided that the
  Stockholders' Agents shall treat confidentially and not disclose any
  nonpublic information from or about Promedix or Chemdex to anyone (except
  on a need to know basis to individuals who agree to treat such information
  confidentially).

   Section 10.9 Actions of the Stockholders' Agents. A decision, act, consent
or instruction of the Stockholders' Agents shall constitute a decision of all
of the Former Promedix Stockholders for whom shares of Chemdex Common Stock
otherwise issuable to them are deposited in the Escrow Fund and shall be final,
binding and conclusive upon each such Former Promedix Stockholder, and the
Escrow Agent and Chemdex may rely upon any decision, act, consent or
instruction of the Stockholders' Agents as being the decision, act, consent or
instruction of each and every such Former Promedix Stockholder. The Escrow
Agent and Chemdex are hereby relieved from any liability to any person for any
acts done by them in accordance with such decision, act, consent or instruction
of the Stockholders' Agents.

   Section 10.10 Claims. In the event Chemdex becomes aware of a third-party
claim which Chemdex believes may result in a demand against the Escrow Fund,
Chemdex shall promptly notify the Stockholders' Agents of such claim, and the
Stockholders' Agents and the Former Promedix Stockholders for whom shares of
Chemdex Common Stock otherwise issuable to them are deposited in the Escrow
Fund shall be entitled, at their

                                      A-92
<PAGE>

expense, to participate in any defense of such claim. Chemdex shall have the
right in its sole discretion to settle any such claim; provided, however, that
Chemdex may not effect the settlement of any such claim without the consent of
the Stockholders' Agents, which consent shall not be unreasonably withheld. In
the event that the Stockholders' Agents have consented to any such settlement,
the Stockholders' Agents shall have no power or authority to object to the
amount of any claim by Chemdex against the Escrow Fund for indemnity with
respect to such settlement in the amount agreed to.

                                  APPENDIX II

                        HOLDERS' INTEREST IN ESCROW FUND

<TABLE>
<CAPTION>
             Chemdex
             Shares  Percentage
               to    of Escrow
Stockholder  Escrow    Shares
- -----------  ------- ---------- ---
<S>          <C>     <C>        <C>










               ---     ------   ---
  Totals               100.00%
               ===     ======   ===
</TABLE>

                                      A-93
<PAGE>

                                   EXHIBIT F

                 SUBJECT MATTER OF OPINION OF PROMEDIX COUNSEL

                                      A-94
<PAGE>

                                   EXHIBIT G

                                 LOAN AGREEMENT

                                      A-95
<PAGE>

                                   EXHIBIT G

                     SECURED PROMISSORY NOTE AND AGREEMENT

                             ("Note and Agreement")

$10,000,000.00                                              Salt Lake City, Utah
                                                              September   , 1999

   FOR VALUE RECEIVED, Promedix.com, Inc., a Delaware corporation ("Borrower"),
hereby promises to pay to the order of Chemdex Corporation, a Delaware
corporation ("Lender"), the principal sum of TEN MILLION DOLLARS
($10,000,000.00) or such lesser amount as shall equal the outstanding principal
amount of all sums advanced to Borrower hereunder and to pay interest on the
outstanding balance of said sum at a rate per annum equal to nine percent (9%),
compounded annually. All then outstanding principal and accrued interest
hereunder shall be due and payable in full upon the earlier of (i) September
  , 2000 in the event that the Agreement and Plan of Merger dated as of
September   , 1999 (the "Merger Agreement") by and among Borrower, Lender and a
wholly owned subsidiary of Lender shall be terminated for any reason pursuant
to the terms of Article IX thereof [the first anniversary of the signing date];
(ii) the sale of all or substantially all of the assets of Borrower to any
person or entity other than Lender or an affiliate of Lender or the acquisition
of Borrower by any person or entity other than Lender or an affiliate of Lender
by means of a transaction that results in the transfer of more than forty
percent (40%) of the total outstanding power of Borrower; or (iii) December 31,
2000 (the "Maturity Date"). The events described in items (i) through (iii)
above are collectively referred to herein as "Note Termination Events."

   In the event that Borrower receives any debt or equity financing in excess
of $500,000 at any time (and from time to time) prior to September   , 2000,
Borrower agrees that twenty-five percent (25%) of any amounts so raised shall
be used by Borrower to immediately repay amounts that may be outstanding
hereunder, whether or not such amounts may be due under the immediately
preceding paragraph.

   Borrower shall make all payments hereunder for the account of Lender at 3950
Fabian Way, Palo Alto, California 94308, or to such other address as Lender
shall notify Borrower, in lawful money of the United States and in same day or
immediately available funds not later than 12:00 noon on the date due, or as
otherwise agreed to by Lender. Any and all amounts owing under this Note and
Agreement may be prepaid at any time and from time to time by Borrower without
penalty.

   All computations of interest under this Note and Agreement shall be based on
a year of 365 or 366 days, as applicable, for actual days elapsed. In the event
that, Borrower pays interest under this Note and Agreement and it is determined
that such interest rate was in excess of the then legal maximum rate, then that
portion of the interest payment representing an amount in excess of the then
legal maximum rate shall be deemed a payment of principal and applied against
the principal then due under this Note and Agreement.

Merger Agreement

   This Note and Agreement is being entered into in connection with the Merger
Agreement (as the same may be amended, restated, supplemented or otherwise
modified pursuant to the terms thereof). Capitalized terms used herein and not
otherwise defined herein shall have the respective meanings set forth in the
Merger Agreement.

Security Agreement

   This Note and Agreement is secured by certain collateral (the "Collateral")
more specifically described in (i) the Security Agreement of even date herewith
between Borrower and Lender, and (ii) the Patent and Trademark Security
Agreement of even date herewith between Borrower and Lender (such two
agreements together, the "Security Agreement").

                                      A-96
<PAGE>

Conditions to Advances; Use of Proceeds; Covenants

   Amounts shall be advanced to Borrower under this Note and Agreement solely
in accordance with the terms and conditions set forth in this Note and
Agreement, including Schedule A attached hereto and incorporated herein by
reference. Borrower shall use the proceeds of any amount advanced under this
Note and Agreement solely for general corporate purposes, including normal
working capital in the ordinary course of business as presently conducted and
as presently proposed to be conducted. Until the termination of this Note and
Agreement and payment in full by Borrower or forgiveness by Lender of all
amounts outstanding under this Note and Agreement, Borrower agrees that it
shall comply with and duly perform all of its covenants, obligations and
agreements set forth in the Merger Agreement, which are hereby incorporated
herein by reference as if fully set forth herein.

Representations and Warranties

   Borrower represents and warrants to Lender that:

     (a) Borrower is a corporation duly organized, validly existing and in
  good standing under the law of the State of Delaware and has all requisite
  corporate power and authority to execute, deliver and perform its
  obligations under this Note and Agreement.

     (b) The execution, delivery and performance by Borrower of this Note and
  Agreement have been duly authorized by all necessary corporate action of
  Borrower, and this Note and Agreement constitutes the legal, valid and
  binding obligation of Borrower, enforceable against Borrower in accordance
  with its terms.

     (c) No authorization, consent, approval, license, exemption of, or
  filing or registration with, any governmental authority or agency, or
  approval or consent of any other person or entity, is required for the due
  execution, delivery or performance by Borrower of this Note and Agreement.

Events of Default

   The occurrence of any one or more of the following events shall constitute
an "Event of Default" hereunder:

     (d) Borrower shall fail to pay any then outstanding principal when due
  or any interest or other amount payable under this Note and Agreement
  within five (5) business days of when due; or

     (e) Borrower shall fail in any material respect to perform any of its
  other covenants, obligations or agreements contained in this Note and
  Agreement or the Merger Agreement and such failure shall continue for ten
  (10) business days after written notice thereof by Lender; or

     (f) Any representation, warranty, certificate, or other statement
  (financial or otherwise) made or furnished by or on behalf of Borrower in
  writing to Lender in connection with this Note and Agreement or the Merger
  Agreement, or as an inducement to Lender to advance the sums under this
  Note and Agreement or to enter into the Merger Agreement, shall have been
  false or incorrect, in any material respect when made or shall become false
  or incorrect in any material respect following the date hereof; or

     (g) Borrower (i) shall fail to make any payment when due under the terms
  of any bond, debenture, note or other evidence of indebtedness, if any,
  individually in excess of $500,000 to be paid by Borrower, and such failure
  shall continue beyond any period of grace provided with respect thereto, or
  (ii) shall default in the observance or performance of any other agreement,
  term or condition contained in any such bond, debenture, note or other
  evidence of indebtedness providing for principal payments in excess of
  $500,000, and in the case of either clause (i) or (ii) the effect of such
  failure or default is to cause the holder or holders thereof to accelerate
  the indebtedness to become due prior to its stated date of maturity; or

                                      A-97
<PAGE>

     (h) Borrower shall (i) apply for or consent to the appointment of a
  receiver, trustee, liquidator or custodian of itself or of all or any part
  of its property; (ii) admit in writing its inability, to pay its debts
  generally as they mature; (iii) make a general assignment for the benefit
  of its or any of its creditors; (iv) be dissolved or liquidated in full or
  in part; (v) become insolvent (as such term may be defined or interpreted
  under any applicable statute); (vi) commence a voluntary case or other
  proceeding seeking liquidation, reorganization or other relief with respect
  to itself or its debts under any bankruptcy, insolvency or other similar
  law now or hereafter in effect or consent to any such relief or to the
  appointment of or taking possession of its property by any official in an
  involuntary case or other proceeding commenced against it; or (vii) take
  any action for the purpose of affecting any of the foregoing; or

     (i) Proceedings for the appointment of a receiver, trustee, liquidator
  or custodian of Borrower or of all or any material part of its property, or
  an involuntary case or other proceedings seeking liquidation,
  reorganization or other relief with respect to Borrower or the debts
  thereof under any bankruptcy, insolvency or other similar law now or
  hereafter in effect, shall be commenced and an order for relief entered or
  such proceeding shall not be dismissed or discharged within sixty (60) days
  of commencement; or

     (j) A final judgment or final judgments for the payment of money, which
  individually or in the aggregate, exceed $500,000 in excess of the amount
  covered by insurance, shall be rendered against Borrower and the same shall
  remain undischarged for a period of thirty (30) days during which execution
  shall not be effectively stayed; or any judgment, writ, assessment, warrant
  of attachment, execution, levy or similar process shall be issued or levied
  against any material part of the property of Borrower and such judgment,
  writ, assessment, warrant of attachment, execution, levy or similar process
  shall not be released, stayed, vacated or otherwise dismissed within ten
  (10) days after issue or levy; or

     (k) This Note and Agreement shall cease to be, or be asserted by
  Borrower not to be, a legal, valid and binding obligation of Borrower,
  enforceable in accordance with its terms; or

     (l) An "Event of Default" (as defined in the Security Agreement) shall
  have occurred.

Upon the occurrence or existence of any Event of Default, Lender may (a) at any
time terminate any obligation to make loans or advance sums to Borrower under
this Note and Agreement; (b) at any time declare all unpaid amounts owing or
payable under this Note and Agreement to be immediately due and payable without
presentment, demand, protest or any other notice of any kind, all of which are
hereby expressly waived by Borrower; and/or (c) exercise all rights and
remedies available to Lender under this Note and Agreement, the Security
Agreement or applicable law; provided, however, that upon the occurrence or
existence of any Event of Default described in clause (h) or (i) above,
immediately and without notice, (i) any obligation to make loans or advance
sums to Borrower under this Note and Agreement shall automatically terminate
and (ii) all unpaid amounts owing or payable under this Note and Agreement
shall automatically become immediately due and payable, without presentment,
demand, protest or any other notice of any kind, all of which are hereby
expressly waived by Borrower.

   Borrower agrees to pay on demand all reasonable costs and expenses of
Lender, and the reasonable fees and disbursements of counsel, in connection
with the enforcement or attempted enforcement of, and preservation of any
rights or interests under, this Note and Agreement, including in any out-of-
court workout or other refinancing or restructuring or in any bankruptcy case.
Any amounts payable to Lender pursuant to this paragraph if not paid upon
demand shall bear interest from the date of such demand until paid in full, at
the rate of interest set forth herein in respect of principal outstanding
hereunder.

   If at any time any provision of this Note and Agreement is or becomes
illegal, invalid or unenforceable in any respect, neither the legality,
validity nor enforceability of the remaining provisions shall in any way be
affected or impaired thereby.

                                      A-98
<PAGE>

   Any term, covenant, agreement or condition of this Note and Agreement may be
amended or waived if such amendment or waiver is in writing and is signed by
Borrower and Lender. No failure or delay by Lender in exercising any right or
remedy hereunder shall operate as a waiver thereof or of any other right or
remedy nor shall any single or partial exercise of any such right or remedy
preclude any other further exercise thereof or of any other right or remedy.
The acceptance at any time by Lender of any past-due amount hereunder shall not
be deemed to be a waiver of the right to require prompt payment when due of any
other amounts then or thereafter due and payable. Unless otherwise specified in
such waiver or consent, a waiver or consent given hereunder shall be effective
only in the specific instance and for the specific purpose for which given.

   This Note and Agreement shall be binding upon and inure to the benefit of
Borrower, Lender, and their respective successors and permitted assigns, except
that Borrower may not assign or transfer any of its rights or obligations under
this Note and Agreement without the prior written consent of Lender. Prior to
the occurrence of any Note Termination Event, Lender may at any time sell,
assign, or otherwise transfer only to any of its affiliates or subsidiaries all
or part of the obligations of Borrower and Lender under this Note and
Agreement. After the occurrence of any Note Termination Event, Lender may at
any time sell, assign, or otherwise transfer to any other person or entity all
or part of the obligations of Borrower and Lender under this Note and
Agreement.

   Nothing expressed in or to be implied from this Note and Agreement is
intended to give, or shall be construed to give, any person or entity, other
than the parties hereto and their permitted successors and assigns hereunder,
any benefit or legal or equitable right, remedy or claim under or by virtue of
this Note and Agreement or under or by virtue of any provision herein.

   The words "hereof," "herein," "hereunder" and similar words refer to this
Note and Agreement as a whole (including the Schedules attached hereto) and not
to any particular provision of this Note and Agreement.

   Borrower hereby waives presentment, demand, protest, notice of dishonor and
all other notices, except as expressly provided herein, any release or
discharge arising from any extension of time, discharge of a prior party, or
other cause of release or discharge other than actual payment in full hereof.

   This Note and Agreement shall be construed in accordance with and governed
by the laws of the State of California, excluding conflict of laws principles.

   All notices and other communications hereunder shall be given as provided in
Section 11.2 of the Merger Agreement.

                                      A-99
<PAGE>

   IN WITNESS WHEREOF, the undersigned duly authorized officer of Borrower has
executed this Note and Agreement as of the date first set forth above.

                                          PROMEDIX.COM, INC.

                                          By:__________________________________
                                             Name:
                                             Title:


                                     A-100
<PAGE>

                                                                      Schedule A

                           CONDITIONS TO ANY ADVANCE

   Subject to the terms and conditions set forth herein and in the Note and
Agreement, Lender agrees to advance to Borrower from time to time on the
"Advance Dates" set forth below, such loans as Borrower may request hereunder
(each such loan an "Advance" and collectively, the "Advances"); provided,
however, that the aggregate principal amount of all Advances hereunder shall
not exceed Ten Million Dollars ($10,000,000); provided, further, that the
aggregate principal amount of each Advance on any Advance Date shall not exceed
the amount of One Million Six Hundred Sixty Six Thousand Six Hundred Sixty
Seven Dollars ($1,666,667). Borrower agrees and acknowledges that upon the
occurrence of any Note Termination Event, Lender's obligation to advance any
unadvanced amounts hereunder shall automatically terminate and be of no further
force and effect and all then outstanding principal and accrued interest
hereunder shall be immediately due and payable in full.

   a. Advance Dates. Upon the request of the Borrower as provided in paragraph
b. below, provided that no Note Termination Event shall have occurred and
subject to the other terms and conditions set forth herein, Lender shall make
Advances hereunder on each of (1) October 1, 1999, (2) November 1, 1999,
(3) December 1, 1999, (4) January 1, 2000, (5) February 1, 2000 and (6) March
1, 2000 (each such date, and any other date on which Lender makes an Advance,
an "Advance Date", and collectively, the "Advance Dates").

   b. Borrowing Request. Borrower shall request each Advance by delivering to
Lender an irrevocable written notice (the "Borrowing Request") which shall
specify (i) the principal amount of the requested Advance, (ii) the applicable
Advance Date, (iii) the account or accounts to which Lender shall disburse the
proceeds of the requested Advance, and (iv) that all conditions set forth in
paragraph c. below have been satisfied in respect of such Advance. Each
Borrowing Request shall be in writing and shall be given to Lender at least
five (5) business days before the applicable Advance Date by delivery of such
notice to Lender to the address and in the manner set forth in Section 11.2 of
the Merger Agreement. Disbursements of any Advance shall be made by wire
transfer to the account(s) of Borrower specified in the Borrowing Request
before the close of business on the applicable Advance Date; provided, however,
that Lender shall not be deemed to be in default hereunder if it fails to make
such Advance provided that it cures such failure within five (5) business days
after written notice thereof by Borrower.

   c. Conditions Precedent to Each Advance. The obligation of Lender to make
any Advance is subject to the satisfaction of the following conditions, each in
form and substance reasonably satisfactory to Lender:

     (i) The representations and warranties of Borrower set forth in the Note
  and Agreement and in the Merger Agreement shall be true and correct in all
  material respects on each Advance Date as if made on such date and shall
  remain true and correct in all material respects;

     (ii) No Event of Default or event which with the giving of notice or
  lapse of time, or both, would constitute an Event of Default shall have
  occurred or be continuing;

     (iii) The Collateral shall be subject to no mortgages, liens, security
  interests, pledges, charges or encumbrances of any kind or character,
  except (A) liens in favor of Lender, (B) nonconsensual liens arising in the
  ordinary course of business which alone or in the aggregate are not
  substantial in amount and which do not materially detract from the value of
  the property subject thereto or interfere with the ordinary conduct of the
  business of the Borrower or otherwise impair Lender's rights with respect
  thereto and (C) Permitted Liens (as defined in the Security Agreement);

     (iv) Lender shall have a perfected first priority security interest in
  and to all of the Collateral, subject to the Permitted Liens; and

     (v) No Note Termination Event shall have occurred.

                                     A-101
<PAGE>

   The submission by Borrower of each Borrowing Request shall be deemed to be a
representation and warranty by Borrower as of the date thereof and as of the
applicable Advance Date that the conditions in this paragraph c. are satisfied.

                                     A-102
<PAGE>

                               SECURITY AGREEMENT

   THIS SECURITY AGREEMENT (this "Agreement"), dated as of September   , 1999,
is made by and between Promedix.com, Inc., a Delaware corporation ("Debtor"),
and Chemdex Corporation, a Delaware corporation ("Secured Party").

   Debtor and Secured Party hereby agree as follows:

   Section 1 Definitions; Interpretation.

   (a) As used in this Agreement, the following terms shall have the following
meanings:

     "Collateral" has the meaning set forth in Section 2.

     "Documents" means this Agreement, the Note, the Merger Agreement and all
  other certificates, documents, agreements and instruments delivered to
  Secured Party under the Note or in connection with the Obligations.

     "Event of Default" has the meaning set forth in Section 8.

     "Lien" means any mortgage, deed of trust, pledge, security interest,
  assignment, deposit arrangement, charge or encumbrance, lien, or other type
  of preferential arrangement.

     "Merger Agreement" means the Agreement and Plan of Merger, dated as of
  September   , 1999 among Debtor, Secured Party and a wholly owned
  subsidiary of Secured Party.

     "Note" means that certain Secured Promissory Note and Agreement of even
  date herewith made by Debtor in favor of Secured Party, as amended,
  modified, renewed, extended or replaced from time to time.

     "Obligations" means the indebtedness, liabilities and other obligations
  of Debtor to Secured Party under or in connection with this Agreement and
  the Note, including, without limitation, all unpaid principal of the Note,
  all interest accrued thereon, all fees and all other amounts payable by
  Debtor to Secured Party thereunder or in connection therewith, whether now
  existing or hereafter arising, and whether due or to become due, absolute
  or contingent, liquidated or unliquidated, determined or undetermined.

     "Permitted Lien" means (i) any Lien in favor of Secured Party, (ii)
  nonconsensual Liens which arise in the ordinary course of business and do
  not materially impair Debtor's ownership or use of the Collateral or the
  value thereof, (iii) purchase money security interests and liens in
  connection with capital leases incurred in the ordinary course of business,
  (iv) liens existing on property as of the date of this Agreement, (v) liens
  existing on property at the time of its acquisition by the Debtor, (vi)
  liens securing the performance of bids, trade contracts, leases, surety
  bonds and the like, and (vii) liens in connection with judgments that do
  not constitute an Event of Default under the Note.

     "Person" means an individual, corporation, partnership, joint venture,
  trust, unincorporated organization, governmental agency or authority, or
  any other entity of whatever nature.

     "UCC" means the Uniform Commercial Code as the same may, from time to
  time, be in effect in the State of Utah; provided, however, in the event
  that, by reason of mandatory provisions of law, any or all of the
  attachment, perfection or priority of the security interest in any
  Collateral is governed by the Uniform Commercial Code as in effect in a
  jurisdiction other than the State of Utah, the term "UCC" shall mean the
  Uniform Commercial Code as in effect in such other jurisdiction for
  purposes of the provisions hereof relating to such attachment, perfection
  or priority and for purposes of definitions related to such provisions.

   (b) Where applicable and except as otherwise defined herein, terms used in
this Agreement shall have the meanings assigned to them in the UCC.

                                     A-103
<PAGE>

   (c) In this Agreement, (i) the meaning of defined terms shall be equally
applicable to both the singular and plural forms of the terms defined; and (ii)
the captions and headings are for convenience of reference only and shall not
affect the construction of this Agreement.

   Section 2 Security Interest.

     (a) As security for the payment and performance of the Obligations,
  Debtor hereby grants to Secured Party a security interest in, all of
  Debtor's right, title and interest in, to and under the following property,
  wherever located and whether now existing or owned or hereafter acquired or
  arising (collectively, the "Collateral"):

       (i) all accounts, accounts receivable, contract rights, rights to
    payment, chattel paper, letters of credit, documents, securities, money
    and instruments, and investment property, whether held directly or
    through a securities intermediary, and other obligations of any kind
    owed to Debtor, however evidenced;

       (ii) all deposits and deposit accounts with any bank, savings and
    loan association, credit union or like organization, and all funds and
    amounts therein, and whether or not held in trust, or in custody or
    safekeeping, or otherwise restricted or designated for a particular
    purpose;

       (iii) all inventory, including, without limitation, all materials,
    raw materials, parts, components, work in progress, finished goods,
    merchandise, supplies, and all other goods which are held for sale,
    lease or other disposition or furnished under contracts of service or
    consumed in Debtor's business, including, without limitation, those
    held for display or demonstration or out on lease or consignment;

       (iv) all owned equipment, including, without limitation, all
    machinery, furniture, furnishings, fixtures, trade fixtures, tools,
    parts and supplies, automobiles, trucks and other vehicles, appliances,
    computer and other electronic data processing equipment and other
    office equipment, computer programs and related data processing
    software, and all additions, substitutions, replacements, parts,
    accessories, and accessions to and for the foregoing;

       (v) all general intangibles and other personal property of Debtor,
    including, without limitation, (A) all tax and other refunds, rebates
    or credits of every kind and nature to which Debtor is now or hereafter
    may become entitled; (B) all intellectual property and all rights
    therein of any type or description, including, without limitation, all
    inventions and discoveries, patents and patent applications, copyrights
    and applications for copyright (together with the underlying works of
    authorship) whether or not registered, together with any renewals and
    extensions thereof, trademarks, service marks and trade names, and
    applications for registration of such trademarks, service marks and
    trade names, trade secrets, trade dress, trade styles, logos, other
    source of business identifiers, mask-works, mask-work registrations,
    mask-work applications, software, confidential and proprietary
    information, customer lists, other license rights, advertising
    materials, operating manuals, methods, processes, know-how, algorithms,
    formulae, databases, quality control procedures, product, service and
    technical specifications, operating, production and quality control
    manuals, sales literature, drawings, specifications, blue prints,
    descriptions, inventions, name plates and catalogs, and the entire
    goodwill of or associated with the businesses now or hereafter
    conducted by Debtor connected with and symbolized by any of the
    aforementioned properties and assets, and all licenses relating to any
    of the foregoing, all reissuance, continuations and continuations-in-
    part of the foregoing, all other rights derived from or associated with
    the foregoing, including the right to sue and recover for past
    infringement, and all income and royalties with respect thereto; (C)
    all goodwill, chooses in action and causes of action; (D) all interests
    in limited and general partnerships and limited liability companies;
    and (E) all indemnity agreements, guaranties, insurance policies,
    insurance claims, and other contractual, equitable and legal rights of
    whatever kind or nature;

       (vi) all books, records and other written, electronic or other
    documentation in whatever form maintained by or for Debtor in
    connection with the ownership of its assets or the conduct of its
    business or evidencing or containing information relating to the
    Collateral; and

                                     A-104
<PAGE>

       (vii) all products and proceeds, including insurance proceeds, of any
    and all of the foregoing.

     (b) Anything herein to the contrary notwithstanding, (i) Debtor shall
  remain liable under any contracts, agreements and other documents included
  in the Collateral, to the extent set forth therein, to perform all of its
  duties and obligations thereunder to the same extent as if this Agreement
  had not been executed, (ii) the exercise by Secured Party of any of the
  rights hereunder shall not release Debtor from any of its duties or
  obligations under such contracts, agreements and other documents included
  in the Collateral, and (iii) Secured Party shall not have any obligation or
  liability under any contracts, agreements and other documents included in
  the Collateral by reason of this Agreement, nor shall Secured Party be
  obligated to perform any of the obligations or duties of Debtor thereunder
  or to take any action to collect or enforce any such contract, agreement or
  other document included in the Collateral hereunder.

     (c) Notwithstanding the foregoing provisions of this Section 2, the
  grant of a security interest as provided herein shall not extend to, and
  the term "Collateral" shall not include, any general intangibles of Debtor
  (whether owned or held as licensee or lessee, or otherwise), to the extent
  that (i) such general intangibles are not assignable or capable of being
  encumbered as a matter of law or under the terms of the license, lease or
  other agreement applicable thereto (but solely to the extent that any such
  restriction shall be enforceable under applicable law), without the consent
  of the licensor or lessor thereof or other applicable party thereto and
  (ii) such consent has not been obtained; provided, however, that the
  foregoing grant of security interest shall extend to, and the term
  "Collateral" shall include, (A) any general intangible which is an account
  receivable or a proceed of, or otherwise related to the enforcement or
  collection of, any account receivable, or goods which are the subject of
  any account receivable, (B) any and all proceeds of any general intangibles
  which are otherwise excluded to the extent that the assignment or
  encumbrance of such proceeds is not so restricted, and (C) upon obtaining
  the consent of any such licensor, lessor or other applicable party's
  consent with respect to any such otherwise excluded general intangibles,
  (but without obligating Debtor to obtain such consent) such general
  intangibles as well as any and all proceeds thereof that might have
  theretofore have been excluded from such grant of a security interest and
  the term "Collateral."

     (d) This Agreement shall create a continuing security interest in the
  Collateral which shall remain in effect until terminated in accordance with
  Section 19 hereof.

   Section 3 Financing Statements, Etc. Debtor shall execute and deliver to
Secured Party concurrently with the execution of this Agreement, and at any
time and from time to time thereafter, all financing statements, assignments,
continuation financing statements, termination statements, account control
agreements, and other documents and instruments, in form reasonably
satisfactory to Secured Party, and take all other action, as Secured Party may
reasonably request, to perfect and continue perfected, maintain the priority
of or provide notice of the security interest of Secured Party in the
Collateral and to accomplish the purposes of this Agreement.

   Section 4 Representations and Warranties. Debtor represents and warrants to
Secured Party as of the date of this Agreement that:

     (a) Debtor is a corporation duly organized, validly existing and in good
  standing under the law of the jurisdiction of its incorporation and has all
  requisite corporate power and authority to execute, deliver and perform its
  obligations under this Agreement.

     (b) The execution, delivery and performance by Debtor of this Agreement
  have been duly authorized by all necessary corporate action of Debtor, and
  this Agreement constitutes the legal, valid and binding obligation of
  Debtor, enforceable against Debtor in accordance with its terms.

     (c) No authorization, consent, approval, license, exemption of, or
  filing or registration with, any governmental authority or agency, or
  approval or consent of any other Person, is required for the due execution,
  delivery or performance by Debtor of this Agreement.

                                     A-105
<PAGE>

     (d) Debtor's chief executive office and principal place of business is
  located at the address set forth in Schedule 1; all other locations where
  Debtor conducts business or Collateral is kept are set forth in Schedule 1;
  and all trade names and fictitious names under which Debtor at any time in
  the past has conducted or presently conducts its business operations are
  set forth in Schedule 1 or Schedule 2.

     (e) Debtor is the sole and complete owner of the Collateral, free from
  any Lien other than Permitted Liens.

     (f) All of Debtor's U.S. and foreign patents and patent applications,
  copyrights (whether or not registered), applications for copyright,
  trademarks, service marks and trade names (whether registered or
  unregistered), and applications for registration of such trademarks,
  service marks and trade names, are set forth in Schedule 2.

   Section 5 Covenants. So long as any of the Obligations remain unsatisfied,
or until this Security Agreement has terminated pursuant to Section 19 hereof,
Debtor agrees that Debtor shall not do, cause, or permit any of the following
without the prior consent of Secured Party:

     (a) Debtor shall appear in and defend any action, suit or proceeding
  which may affect to a material extent its title to, or right or interest
  in, or Secured Party's right or interest in any material portion of the
  Collateral, and shall do and perform all reasonable acts that may be
  necessary and appropriate to maintain, preserve and protect the Collateral
  in all material respects.

     (b) Debtor shall give prompt written notice to Secured Party (and in any
  event not later than 30 days following any change described below in this
  subsection) of: (i) any change in the location of Debtor's chief executive
  office or principal place of business, (ii) any change in the locations set
  forth in Schedule 1; (iii) any change in its name, (iv) any changes in,
  additions to or other modifications of its trade names and trade styles set
  forth in Schedule 1 or Schedule 2, and (v) any changes in its identity or
  structure in any manner which might make any financing statement filed
  hereunder incorrect or misleading.

     (c) Debtor shall carry and maintain in full force and effect, at its own
  expense and with financially sound and reputable insurance companies,
  insurance with respect to the Collateral in such amounts, with such
  deductibles and covering such risks as is customarily carried by companies
  engaged in the same or similar businesses of similar size and owning
  similar properties in the localities where Debtor operates.

     (d) All insurance policies shall provide that Secured Party shall be a
  loan payee. During the continuance of an Event of Default and so long as
  the Obligations have been accelerated, in its sole discretion, Secured
  Party may apply all or any portion of such insurance proceeds to the
  payment of Obligations or may release all or any portion thereof to Debtor.

     (e) Debtor shall keep accurate and complete books and records in
  accordance with generally accepted accounting principles.

     (f) Debtor shall not surrender or lose possession of (other than to
  Secured Party), sell, lease, rent, or otherwise dispose of or transfer any
  of the Collateral or any right or interest therein, except in the ordinary
  course of business and except to the extent obsolete or no longer useful to
  its business; provided that no such disposition or transfer of Collateral
  consisting of investment property or instruments shall be permitted while
  any Event of Default exists.

     (g) Debtor shall keep the Collateral free of all Liens except Permitted
  Liens.

     (h) Debtor shall pay and discharge all material taxes, fees, assessments
  and governmental charges or levies imposed upon it with respect to the
  Collateral prior to the date on which penalties attach thereto, except to
  the extent such taxes, fees, assessments or governmental charges or levies
  are being contested in good faith by appropriate proceedings.

     (i) Debtor shall maintain and preserve its corporate existence, its
  rights to transact business and all other rights, franchises and privileges
  necessary or desirable in the normal course of its business and operations
  and the ownership of the Collateral, except in connection with any
  transactions expressly permitted by the Note or any other Document.

                                     A-106
<PAGE>

     (j) Upon the request of Secured Party after the occurrence of an Event
  of Default, Debtor shall (1) immediately deliver to Secured Party, or an
  agent designated by it, appropriately endorsed or accompanied by
  appropriate instruments of transfer or assignment, all documents and
  instruments, all certificated securities with respect to any investment
  property, all letters of credit and all accounts and other rights to
  payment at any time evidenced by promissory notes, trade acceptances or
  other instruments, (ii) cause any securities intermediaries to show on
  their books that Secured Party is the entitlement holder with respect to
  any investment property, and/or obtain account control agreements in favor
  of Secured Party from such securities intermediaries, in form and substance
  satisfactory to Secured Party, with respect to any investment property, as
  requested by Secured Party, (iii) mark all documents and chattel paper with
  such legends as Secured Party shall reasonably specify, and (iv) obtain
  consents from any letter of credit issuers with respect to the assignment
  to Secured Party of any letter of credit proceeds.

     (k) Debtor shall (i) notify Secured Party of any material claim made or
  asserted against the Collateral by any Person or other event which could
  reasonably be expected to materially adversely affect the value of the
  Collateral or Secured Party's Lien thereon; (ii) furnish to Secured Party
  such statements and schedules further identifying and describing the
  Collateral and such other reports and other information in connection with
  the Collateral as Secured Party may reasonably request, all in reasonable
  detail; and (iii) upon reasonable request of Secured Party make such
  demands and requests for information and reports as Debtor is entitled to
  make in respect of the Collateral.

     (l) If and when Debtor shall obtain rights to any new patents,
  trademarks, service marks, trade names or copyrights, or otherwise acquire
  or become entitled to the benefit of, or apply for registration of, any of
  the foregoing, Debtor (i) shall promptly notify Secured Party thereof and
  (ii) hereby authorizes Secured Party to modify, amend, or supplement
  Schedule 2 and from time to time to include any of the foregoing and make
  all necessary or appropriate filings with respect thereto.

     (m) Debtor shall not enter into any material agreement (including any
  license or royalty agreement) pertaining to any of its patents, copyrights,
  trademarks, service marks and trade names, except for non-exclusive
  licenses in the ordinary course of business.

     (n) Debtor shall give Secured Party immediate notice of the
  establishment of any new deposit account and any new securities account
  with respect to any investment property.

   Section 6 Collection of Accounts. Until Secured Party exercises its rights
hereunder to collect the accounts and other rights to payment, Debtor shall
endeavor in the first instance diligently to collect all amounts due or to
become due on or with respect to the accounts and other rights to payment. At
the request of Secured Party, upon the occurrence and during the continuance of
any Event of Default, all remittances received by Debtor shall be held in trust
for Secured Party and, in accordance with Secured Party's instructions,
remitted to Secured Party or deposited to an account of Secured Party in the
form received (with any necessary endorsements or instruments of assignment or
transfer). At the request of Secured Party, upon and after the occurrence of
any Event of Default, Secured Party shall be entitled to receive all
distributions and payments of any nature with respect to any investment
property or instruments, and all such distributions or payments received by the
Debtor shall be held in trust for Secured Party and, in accordance with Secured
Party's instructions, remitted to Secured Party or deposited to an account with
Secured Party in the form received (with any necessary endorsements or
instruments of assignment or transfer). Following the occurrence of an Event of
Default any such distributions and payments with respect to any investment
property held in any securities account shall be held and retained in such
securities account, in each case as part of the Collateral hereunder.
Additionally, Secured Party shall have the right, upon the occurrence of an
Event of Default, following prior written notice to the Debtor, to vote and to
give consents, ratifications and waivers with respect to any investment
property and instruments, and to exercise all rights of conversion, exchange,
subscription or any other rights, privileges or options pertaining thereto, as
if Secured Party were the absolute owner thereof; provided that Secured Party
shall have no duty to exercise any of the foregoing rights afforded to it and
shall not be responsible to the Debtor or any other Person for any failure to
do so or delay in doing so.

                                     A-107
<PAGE>

   Section 7 Authorization; Secured Party Appointed Attorney-in-Fact. Secured
Party shall have the right to, in the name of Debtor, or in the name of Secured
Party or otherwise, upon notice to but without the requirement of assent by
Debtor, and Debtor hereby constitutes and appoints Secured Party (and any of
Secured Party's officers, employees or agents designated by Secured Party) as
Debtor's true and lawful attorney-in-fact, with full power and authority to:
(i) sign any of the financing statements and other documents and instruments
which must be executed or filed to perfect or continue perfected, maintain the
priority of or provide notice of Secured Party's security interest in the
Collateral (including any notices to or agreements with any securities
intermediary); (ii) assert, adjust, sue for, compromise or release any claims
under any policies of insurance; and (iii) execute any and all such other
documents and instruments, and do any and all acts and things for and on behalf
of Debtor, which Secured Party may deem reasonably necessary or advisable to
maintain, protect, realize upon and preserve the Collateral and Secured Party's
security interest therein and to accomplish the purposes of this Agreement.
Secured Party agrees that, except upon and during the continuance of an Event
of Default, it shall not exercise the power of attorney, or any rights granted
to Secured Party, pursuant to clauses (ii) and (iii). The foregoing power of
attorney is coupled with an interest and irrevocable so long as the Obligations
have not been paid and performed in full. Debtor hereby ratifies, to the extent
permitted by law, all that Secured Party shall lawfully and in good faith do or
cause to be done by virtue of and in compliance with this Section 7.

   Section 8 Events of Default. Any of the following events which shall occur
and be continuing shall constitute an "Event of Default":

     (a) Any "Event of Default" as defined in the Note shall have occurred.

     (b) Any representation or warranty by Debtor under or in connection with
  this Agreement, shall prove to have been incorrect in any material respect
  when made or shall become incorrect in any material respect following the
  date hereof.

     (c) Debtor shall fail to perform or observe in any material respect any
  other term, covenant or agreement contained in this Agreement, on its part
  to be performed or observed and any such failure shall remain unremedied
  for a period of 10 days after written notice thereof by Secured Party.

     (d) Any loss, theft or substantial damage to, or destruction of, any
  material portion of the Collateral (unless within 10 days after the
  occurrence of any such event, Debtor furnishes to Secured Party evidence
  satisfactory to Secured Party that the amount of any such loss, theft,
  damage to or destruction of the Collateral is adequately insured under
  policies naming Secured Party as an additional named insured or loss
  payee).

   Section 9 Remedies.

     (a) Prior to termination of this Security Agreement, and upon the
  occurrence and continuance of an Event of Default, Secured Party may
  declare any of the Obligations to be immediately due and payable and shall
  have, in addition to all other rights and remedies granted to it in this
  Agreement or the Note, all rights and remedies of a secured party under the
  UCC and other applicable laws. Without limiting the generality of the
  foregoing, Secured Party may sell, resell, lease, use, assign, license,
  sublicense, transfer or otherwise dispose of any or all of the Collateral
  in its then condition or following any commercially reasonable preparation
  or processing (utilizing in connection therewith any of Debtor's assets,
  without charge or liability to Secured Party therefor) at public or private
  sale, by one or more contracts, in one or more parcels, at the same or
  different times, for cash or credit, or for future delivery without
  assumption of any credit risk, all as Secured Party deems advisable;
  provided, however, that Debtor shall be credited with the net proceeds of
  sale only when such proceeds are finally collected by Secured Party.
  Secured Party shall have the right upon any such public sale, and, to the
  extent permitted by law, upon any such private sale, to purchase the whole
  or any part of the Collateral so sold, free of any right or equity of
  redemption, which right or equity of redemption Debtor hereby releases, to
  the extent permitted by law. Debtor hereby agrees that the sending of
  notice by ordinary mail, postage prepaid, to the address of Debtor

                                     A-108
<PAGE>

  set forth herein, of the place and time of any public sale or of the time
  after which any private sale or other intended disposition is to be made,
  shall be deemed reasonable notice thereof if such notice is sent ten days
  prior to the date of such sale or other disposition or the date on or after
  which such sale or other disposition may occur.

     (b) For the purpose of enabling Secured Party to exercise its rights and
  remedies under this Section 9 or otherwise in connection with this
  Agreement, Debtor hereby grants to Secured Party an irrevocable, non-
  exclusive and assignable license (exercisable without payment or royalty or
  other compensation to Debtor) to use, license or sublicense any
  intellectual property Collateral.

     (c) The cash proceeds actually received from the sale or other
  disposition or collection of Collateral, and any other amounts received in
  respect of the Collateral the application of which is not otherwise
  provided for herein, shall be applied first, to the payment of the
  reasonable costs and expenses of Secured Party in exercising or enforcing
  its rights hereunder and in collecting or attempting to collect any of the
  Collateral, and to the payment of all other amounts payable to Secured
  Party pursuant to Section 13 hereof; and second, to the payment of the
  Obligations. Any surplus thereof which exists after payment and performance
  in full of the Obligations shall be promptly paid over to Debtor or
  otherwise disposed of in accordance with the UCC or other applicable law.
  Debtor shall remain liable to Secured Party for any deficiency which exists
  after any sale or other disposition or collection of Collateral.

   Section 10 Certain Waivers. Debtor waives, to the fullest extent permitted
by law, (i) any right of redemption with respect to the Collateral, whether
before or after sale hereunder, and all rights, if any, of marshalling of the
Collateral or other collateral or security for the Obligations; (ii) any right
to require Secured Party (A) to proceed against any Person, (B) to exhaust any
other collateral or security for any of the Obligations, (C) to pursue any
remedy in Secured Party's power, or (D) to make or give any presentments,
demands for performance, notices of nonperformance, protests, notices of
protests or notices of dishonor in connection with any of the Collateral; and
(iii) all claims, damages, and demands against Secured Party arising out of the
repossession, retention, sale or application of the proceeds of any sale of the
Collateral.

   Section 11 Notices. All notices and other communications hereunder shall be
given as provided in Section 11.2 of the Merger Agreement.

   Section 12 No Waiver; Cumulative Remedies. No failure on the part of Secured
Party to exercise, and no delay in exercising, any right, remedy, power or
privilege hereunder shall operate as a waiver thereof, nor shall any single or
partial exercise of any such right, remedy, power or privilege preclude any
other or further exercise thereof or the exercise of any other right, remedy,
power or privilege. The rights and remedies under this Agreement are cumulative
and not exclusive of any rights, remedies, powers and privileges that may
otherwise be available to Secured Party.

   Section 13 Costs and Expenses. Debtor agrees to pay on demand: all
reasonable costs and expenses of Secured Party, and the reasonable fees and
disbursements of counsel, in connection with the enforcement or attempted
enforcement of, and preservation of any rights or interests under, this
Agreement and the Note, including in any out-of-court workout or other
refinancing or restructuring or in any bankruptcy case, and the protection,
sale or collection of, or other realization upon, any of the Collateral,
including all expenses of taking, collecting, holding, sorting, handling,
preparing for sale, selling, or the like, and other such expenses of sales and
collections of Collateral. Any amounts payable to Secured Party under this
Section 13 or otherwise under this Agreement if not paid when due shall bear
interest from the date such payment is due until paid in full, at the rate of
interest set forth in the Note.

   Section 14 Binding Effect. This Agreement shall be binding upon, inure to
the benefit of and be enforceable by Debtor, Secured Party and their respective
successors and assigns.

   Section 15 Governing Law. This Agreement shall be governed by, and construed
in accordance with, the law of the State of California, except as required by
mandatory provisions of law and to the extent the validity or perfection of the
security interests hereunder, or the remedies hereunder, in respect of any
Collateral are governed by the law of a jurisdiction other than California.

                                     A-109
<PAGE>

   Section 16 Entire Agreement; Amendment. This Agreement contains the entire
agreement of the parties with respect to the subject matter hereof and shall
not be amended except by the written agreement of the parties.

   Section 17 Severability. Whenever possible, each provision of this Agreement
shall be interpreted in such manner as to be effective and valid under all
applicable laws and regulations. If, however, any provision of this Agreement
shall be prohibited by or invalid under any such law or regulation in any
jurisdiction, it shall, as to such jurisdiction, be deemed modified to conform
to the minimum requirements of such law or regulation, or, if for any reason it
is not deemed so modified, it shall be ineffective and invalid only to the
extent of such prohibition or invalidity without affecting the remaining
provisions of this Agreement, or the validity or effectiveness of such
provision in any other jurisdiction.

   Section 18 Counterparts. This Agreement may be executed in any number of
counterparts and by different parties hereto in separate counterparts, each of
which when so executed shall be deemed to be an original and all of which taken
together shall constitute but one and the same agreement.

   Section 19 Termination. Upon indefeasible payment and performance in full of
all Obligations, this Agreement shall terminate and Secured Party shall
promptly execute and deliver to Debtor such documents and instruments
reasonably requested by Debtor as shall be necessary to evidence termination of
all security interests given by Debtor to Secured Party hereunder; provided,
however, that the obligations of Debtor under Section 13 hereof shall survive
such termination.

                           [Signature page follows.]

                                     A-110
<PAGE>

   IN WITNESS WHEREOF, the parties hereto have duly executed this Agreement, as
of the date first above written.

                                          PROMEDIX.COM, INC.

                                          By:__________________________________
                                             Name:
                                             Title:

                                          CHEMDEX CORPORATION

                                          By:__________________________________
                                             Name:
                                             Title:

                                     A-111
<PAGE>

                                   SCHEDULE 1

                           to the Security Agreement

   1. Locations of Chief Executive Office and Other Locations, Including of
Collateral

     a. Chief Executive Office and Principal Place of Business:

     b. Other locations where Debtor conducts business or Collateral is kept:

   2. Trade Names and Trade Styles; Other Corporate, Trade or Fictitious Names,
Etc.

                                     A-112
<PAGE>

                                   SCHEDULE 2

                           to the Security Agreement

   1. Patents and Patent Applications.

   2. Copyrights (Registered) and Copyright Applications.

   3. Trademarks, Service Marks and Trade Names and Trademark, Service Mark and
Trade Name Applications.

                                     A-113
<PAGE>

                    PATENT AND TRADEMARK SECURITY AGREEMENT

   THIS PATENT AND TRADEMARK SECURITY AGREEMENT (this "Agreement"), dated as of
September   , 1999, is made by and between Promedix.com, Inc., a Delaware
corporation ("Debtor") and Chemdex Corporation, a Delaware corporation
("Secured Party").

   Debtor and Secured Party are parties to a Security Agreement of even date
herewith (as amended, modified, renewed or extended from time to time, the
"Security Agreement"), which Security Agreement provides, among other things,
for the grant by Debtor to Secured Party of a security interest in certain of
Debtor's property and assets, including, without limitation, its patents and
patent applications, its trademarks, service marks and trade names, and its
applications for registration of such trademarks, service marks and trade
names. Pursuant to the Security Agreement, Debtor has agreed to execute and
deliver this Agreement to Secured Party for filing with the United States
Patent and Trademark Office (the "PTO") (and any other relevant recording
systems in any domestic or foreign jurisdiction), and as further evidence of
and to effectuate such grant of a security interest in such patents and patent
applications, trademarks, service marks and trade names, and applications for
registration of such trademarks, service marks and trade names, and the other
general intangibles described herein. Accordingly, Debtor and Secured Party
hereby agree as follows:

   Section 1 Definitions; Interpretation.

      (a) All capitalized terms used in this Agreement and not otherwise
  defined herein shall have the meanings assigned to them in the Security
  Agreement.

      (b) In this Agreement, (i) the meaning of defined terms shall be
  equally applicable to both the singular and plural forms of the terms
  defined; and (ii) the captions and headings are for convenience of
  reference only and shall not affect the construction of this Agreement.

   Section 2 Security Interest.

     (a) As security for the payment and performance of the Obligations (as
  defined in the Security Agreement), Debtor hereby grants a security
  interest in and mortgage to Secured Party, for security purposes, all of
  Debtor's right, title and interest in, to and under the following property,
  whether now existing or owned or hereafter acquired, developed or arising
  (collectively, the "Intellectual Property Collateral"):

        (i) all patents and patent applications, domestic or foreign, all
    licenses relating to any of the foregoing and all income and royalties
    with respect to any licenses (including, without limitation, such
    patents and patent applications as described in Schedule A hereto), all
    rights to sue for past, present or future infringement thereof, all
    rights arising therefrom and pertaining thereto and all reissues,
    divisions, continuations, renewals, extensions and continuations-in-
    part thereof;

       (ii) all state (including common law), federal and foreign
    trademarks, service marks and trade names, and applications for
    registration of such trademarks, service marks and trade names, all
    licenses relating to any of the foregoing and all income and royalties
    with respect to any licenses (including, without limitation, such
    marks, names and applications as described in Schedule B hereto),
    whether registered or unregistered and wherever registered, all rights
    to sue for past, present or future infringement or unconsented use
    thereof, all rights arising therefrom and pertaining thereto and all
    reissues, extensions and renewals thereof;

       (iii) the entire goodwill of or associated with the businesses now
    or hereafter conducted by Debtor connected with and symbolized by any
    of the aforementioned properties and assets;

       (iv) all general intangibles (as defined in the UCC) and all
    intangible intellectual or other similar property of the Debtor of any
    kind or nature, associated with or arising out of any of the
    aforementioned properties and assets and not otherwise described above;
    and

       (v) all products and proceeds of any and all of the foregoing.

                                     A-114
<PAGE>

      (b) This Agreement shall create a continuing security interest in the
  Intellectual Property Collateral which shall remain in effect until
  terminated in accordance with Section 17 hereof.

     (c) Notwithstanding the foregoing provisions of this Section 2, the
  grant of a security interest as provided herein shall not extend to, and
  the term "Collateral" shall not include, any general intangibles of Debtor
  (whether owned or held as licensee or lessee, or otherwise), to the extent
  that (i) such general intangibles are not assignable or capable of being
  encumbered as a matter of law or under the terms of the license, lease or
  other agreement applicable thereto (but solely to the extent that any such
  restriction shall be enforceable under applicable law), without the consent
  of the licensor or lessor thereof or other applicable party thereto and
  (ii) such consent has not been obtained; provided, however, that the
  foregoing grant of security interest shall extend to, and the term
  "Collateral" shall include, (A) any general intangible which is an account
  receivable or a proceed of, or otherwise related to the enforcement or
  collection of, any account receivable, or goods which are the subject of
  any account receivable, (B) any and all proceeds of any general intangibles
  which are otherwise excluded to the extent that the assignment or
  encumbrance of such proceeds is not so restricted, and (C) upon obtaining
  the consent of any such licensor, lessor or other applicable party's
  consent with respect to any such otherwise excluded general intangibles,
  (but without obligating Debtor to obtain such consent) such general
  intangibles as well as any and all proceeds thereof that might have
  theretofore have been excluded from such grant of a security interest and
  the term "Collateral."

   Section 3 Further Assurances; Appointment of Secured Party as Attorney-in-
Fact. Debtor at its expense shall execute and deliver, or cause to be executed
and delivered, to Secured Party any and all documents and instruments, in form
and substance satisfactory to Secured Party, and take any and all action, which
Secured Party may reasonably request from time to time, to perfect and continue
perfected, maintain the priority of or provide notice of Secured Party's
security interest in the Intellectual Property Collateral and to accomplish the
purposes of this Agreement. Secured Party shall have the right to, in the name
of the Debtor, or in the name of Secured Party or otherwise, without notice to
or assent by the Debtor, and the Debtor hereby irrevocably constitutes and
appoints Secured Party (and any of Secured Party's officers or employees or
agents designated by Secured Party) as the Debtor's true and lawful attorney-
in-fact with full power and authority, (i) to sign the name of the Debtor on
all or any of such documents or instruments and perform all other acts that
Secured Party deems necessary or advisable in order to perfect or continue
perfected, maintain the priority or enforceability of or provide notice of
Secured Party's security interest in, the Intellectual Property Collateral, and
(ii) to execute any and all other documents and instruments, and to perform any
and all acts and things for and on behalf of the Debtor, which Secured Party
may deem necessary or advisable to maintain, preserve and protect the
Intellectual Property Collateral and to accomplish the purposes of this
Agreement, including (A) to defend, settle, adjust or (after the occurrence of
any Event of Default) institute any action, suit or proceeding with respect to
the Intellectual Property Collateral, and, after the occurrence of any Event of
Default, (B) to assert or retain any rights under any license agreement for any
of the Intellectual Property Collateral, including without limitation any
rights of the Debtor arising under Section 365(n) of the Bankruptcy Code, and
(C) after the occurrence of any Event of Default, to execute any and all
applications, documents, papers and instruments for Secured Party to use the
Intellectual Property Collateral, to grant or issue any exclusive or non-
exclusive license or sub-license with respect to any Intellectual Property
Collateral, and to assign, convey or otherwise transfer title in or dispose of
the Intellectual Property Collateral; provided, however, that in no event shall
Secured Party have the unilateral power, prior to the occurrence and
continuation of an Event of Default, to assign any of the Intellectual Property
Collateral to any Person, including itself, without the Debtor's written
consent. The foregoing shall in no way limit Secured Party's rights and
remedies upon or after the occurrence of an Event of Default. The power of
attorney set forth in this Section 3, being coupled with an interest, is
irrevocable so long as this Agreement shall not have terminated in accordance
with Section 17.

   Section 4 Future Rights. Except as otherwise expressly agreed to in writing
by Secured Party, if and when the Debtor shall obtain rights to any new
patentable inventions or any new trademarks, or become entitled to the benefit
of any of the foregoing, or obtain rights or benefits with respect to any
reissue, division, continuation, renewal, extension or continuation-in-part of
any patents or trademarks, or any improvement of any patent, the provisions of
Section 2 shall automatically apply thereto and the Debtor shall give to
Secured

                                     A-115
<PAGE>

Party prompt notice thereof. Debtor shall do all things deemed necessary or
advisable by Secured Party to ensure the validity, perfection, priority and
enforceability of the security interests of Secured Party in such future
acquired Intellectual Property Collateral; provided, however, that Debtor shall
not be required to register any patents or trademarks with the PTO except to
the extent consistent with Debtor's past practices. Debtor hereby authorizes
Secured Party to modify, amend, or supplement the Schedules hereto and to
reexecute this Agreement from time to time on Debtor's behalf and as its
attorney-in-fact to include any such future Intellectual Property Collateral
and to cause such reexecuted Agreement or such modified, amended or
supplemented Schedules to be filed with PTO.

   Section 5 Secured Party's Duties. Notwithstanding any provision contained in
this Agreement, Secured Party shall have no duty to exercise any of the rights,
privileges or powers afforded to it and shall not be responsible to the Debtor
or any other Person for any failure to do so or delay in doing so. Except for
the accounting for moneys actually received by Secured Party hereunder or in
connection herewith, Secured Party shall have no duty or liability to exercise
or preserve any rights, privileges or powers pertaining to the Intellectual
Property Collateral.

   Section 6 Representations and Warranties. Debtor represents and warrants to
Secured Party as of the date of this Agreement that:

     (a) A true and correct list of all of the existing Intellectual Property
  Collateral consisting of U.S. patents and patent applications and/or
  registrations owned by the Debtor, in whole or in part, is set forth in
  Schedule A.

     (b) A true and correct list of all of the existing Intellectual Property
  Collateral consisting of U.S. trademarks, trademark registrations and/or
  applications owned by the Debtor, in whole or in part, is set forth in
  Schedule B.

     (c) All patents, trademarks, service marks and trade names of Debtor are
  subsisting and have not been adjudged invalid or unenforceable in whole or
  in part.

     (d) All maintenance fees required to be paid on account of any patents
  or trademarks of Debtor have been timely paid for maintaining such patents
  and trademarks in force, and, to Debtor's knowledge, each of the patents
  and trademarks constituting part of the Intellectual Property Collateral is
  valid and enforceable.

     (e) To Debtor's knowledge, no material infringement or unauthorized use
  presently is being made of any Intellectual Property Collateral by any
  Person.

     (f) To Debtor's knowledge, Debtor is the sole and exclusive owner of the
  Intellectual Property Collateral and the past, present and contemplated
  future use of such Intellectual Property Collateral by Debtor has not, does
  not and will not infringe or violate any right, privilege or license
  agreement of or with any other Person.

   Section 7 Covenants. So long as any of the Obligations remain unsatisfied or
until this Agreement has terminated pursuant to Section 17 hereof, Debtor
agrees that Debtor shall not do, cause or permit any of the following without
the prior consent of Secured Party:

      (a) Assignor will appear in and defend any action, suit or proceeding
  which may affect to a material extent its title to, or Assignee's rights or
  interest in, the Intellectual Property Collateral.

      (b) To the extent deemed reasonably necessary or appropriate by Secured
  Party, Debtor will not allow or suffer any Intellectual Property Collateral
  to become abandoned, nor any registration thereof to be terminated,
  forfeited, expired or dedicated to the public.

     (c) To the extent deemed reasonably necessary or appropriate by Secured
  Party, Debtor will diligently prosecute all applications for patents and
  trademarks, and file and prosecute any and all continuations,
  continuations-in-part, applications for reissue, applications for
  certificate of correction and like matters as shall be reasonable and
  appropriate in accordance with prudent business practice, and promptly pay
  any and all maintenance, license, registration and other fees, taxes and
  expenses incurred in connection with any Intellectual Property Collateral.

                                     A-116
<PAGE>

   Section 8 Secured Party's Rights and Remedies.

      (a) Secured Party shall have all rights and remedies available to it
  under the Security Agreement, the Note and applicable law with respect to
  the security interests in any of the Intellectual Property Collateral or
  any other collateral. Debtor agrees that such rights and remedies include,
  but are not limited to, the right of Secured Party as a secured party to
  sell or otherwise dispose of its collateral after default pursuant to the
  UCC. Debtor agrees that Secured Party shall at all times have such royalty
  free licenses, to the extent permitted by law, for any Intellectual
  Property Collateral that shall be reasonably necessary to permit the
  exercise of any of Secured Party's rights or remedies upon or after the
  occurrence of an Event of Default and shall additionally have the right to
  license and/or sublicense any Intellectual Property Collateral, whether
  general, special or otherwise, and whether on an exclusive or a
  nonexclusive basis, any of the Intellectual Property Collateral, throughout
  the world for such term or terms, on such conditions, and in such manner,
  as Secured Party in its sole discretion shall determine in connection with
  the exercise of any of such rights or remedies. In addition to and without
  limiting any of the foregoing, upon the occurrence and during the
  continuance of an Event of Default, Secured Party shall have the right but
  shall in no way be obligated to bring suit, or to take such other action as
  Secured Party deems necessary or advisable, in the name of the Debtor or
  Secured Party, to enforce or protect any of the Intellectual Property
  Collateral, in which event the Debtor shall, at the request of Secured
  Party, do any and all lawful acts and execute any and all documents
  required by Secured Party in aid of such enforcement. To the extent that
  Secured Party shall elect not to bring suit to enforce such Intellectual
  Property Collateral, Debtor agrees to use all reasonable measures and its
  diligent efforts, whether by action, suit, proceeding or otherwise, to
  prevent the infringement, misappropriation or violations thereof by others
  and for that purpose agrees diligently to maintain any action, suit or
  proceeding against any Person necessary to prevent such infringement,
  misappropriation or violation.

      (b) The cash proceeds actually received from the sale or other
  disposition or collection of Intellectual Property Collateral, and any
  other amounts received in respect of the Intellectual Property Collateral
  the application of which is not otherwise provided for herein, shall be
  applied as provided in the Security Agreement.

   Section 9 Notices. All notices and other communications hereunder shall be
given as provided in Section 11.2 of the Merger Agreement.

   Section 10 No Waiver; Cumulative Remedies. No failure on the part of Secured
Party to exercise, and no delay in exercising, any right, remedy, power or
privilege hereunder shall operate as a waiver thereof, nor shall any single or
partial exercise of any such right, remedy, power or privilege preclude any
other or further exercise thereof or the exercise of any other right, remedy,
power or privilege. The rights and remedies under this Agreement are cumulative
and not exclusive of any rights, remedies, powers and privileges that may
otherwise be available to Secured Party.

   Section 11 Costs and Expenses; Indemnity.

      (a) Debtor agrees to pay on demand all of Secured Party's reasonable
  costs and expenses, including reasonable attorneys' fees, in connection
  with the enforcement or attempted enforcement of, and preservation of any
  rights or interests under, this Agreement, and the assignment, sale or
  other disposal of any of the Intellectual Property Collateral.

      (b) Debtor hereby agrees to indemnify Secured Party, any affiliate
  thereof, and their respective directors, officers, employees, agents,
  counsel and other advisors (each an "Indemnified Person") against, and hold
  each of them harmless from, any and all liabilities, obligations, losses,
  claims, damages, penalties, actions, judgments, suits, costs, expenses or
  disbursements of any kind or nature whatsoever, including, without
  limitation, reasonable attorneys' fees and attorneys' fees incurred
  pursuant to 11 U.S.C., which may be imposed on, incurred by, or asserted
  against any Indemnified Person, relating to or arising out of this
  Agreement, including in connection with any infringement or alleged
  infringement with respect to any Intellectual Property Collateral, or any
  action taken or omitted to be taken by it hereunder (the

                                     A-117
<PAGE>

  "Indemnified Liabilities"); provided that Debtor shall not be liable to any
  Indemnified Person for any portion of such Indemnified Liabilities to the
  extent they are found by a final decision of a court of competent
  jurisdiction to have resulted from such Indemnified Person's gross
  negligence or willful misconduct. If and to the extent that the foregoing
  indemnification is for any reason held unenforceable, Debtor agrees to make
  the maximum contribution to the payment and satisfaction of each of the
  Indemnified Liabilities which is permissible under applicable law.

     (c) Any amounts payable to Secured Party under this Section 11 or
  otherwise under this Agreement if not paid upon demand shall bear interest
  from the date of such demand until paid in full, at the rate of interest
  set forth in the Note.

   Section 12 Binding Effect. This Agreement shall be binding upon, inure to
the benefit of and be enforceable by Debtor, Secured Party and their respective
successors and assigns.

   Section 13 Governing Law. This Agreement shall be governed by, and construed
in accordance with, the law of the State of California, except to the extent
that the validity or perfection of the security interests hereunder in respect
of any Intellectual Property Collateral are governed by federal law and except
to the extent that Secured Party shall have greater rights or remedies under
federal law, in which case such choice of California law shall not be deemed to
deprive Secured Party of such rights and remedies as may be available under
federal law.

   Section 14 Amendment.  This Agreement shall not be amended except by the
written agreement of the parties.

   Section 15 Severability. Whenever possible, each provision of this Agreement
shall be interpreted in such manner as to be effective and valid under all
applicable laws and regulations. If, however, any provision of this Agreement
shall be prohibited by or invalid under any such law or regulation in any
jurisdiction, it shall, as to such jurisdiction, be deemed modified to conform
to the minimum requirements of such law or regulation, or, if for any reason it
is not deemed so modified, it shall be ineffective and invalid only to the
extent of such prohibition or invalidity without affecting the remaining
provisions of this Agreement, or the validity or effectiveness of such
provision in any other jurisdiction.

   Section 16 Counterparts. This Agreement may be executed in any number of
counterparts and by different parties hereto in separate counterparts, each of
which when so executed shall be deemed to be an original and all of which taken
together shall constitute but one and the same agreement.

   Section 17 Termination. Upon payment and performance in full of all
Obligations, this Agreement shall terminate and Secured Party shall promptly
execute and deliver to Debtor such documents and instruments reasonably
requested by Debtor as shall be necessary to evidence termination of all
security interests given by Debtor to Secured Party hereunder, including
cancellation of this Agreement by written notice from Secured Party to the PTO;
provided, however, that the obligations of Debtor under Section 11 hereof shall
survive such termination.

   Section 18 Security Agreement. Debtor acknowledges that the rights and
remedies of Secured Party with respect to the security interests in the
Intellectual Property Collateral granted hereby are more fully set forth in the
Security Agreement and all such rights and remedies are cumulative.

   Section 19 No Inconsistent Requirements. Debtor acknowledges that this
Agreement and the Security Agreement may contain covenants and other terms and
provisions variously stated regarding the same or similar matters, and the
Debtor agrees that all such covenants, terms and provisions are cumulative and
all shall be performed and satisfied in accordance with their respective terms.

   Section 20 Conflicts. In the event of any conflict or inconsistency between
this Agreement and the Security Agreement, the terms of this Agreement shall
control.

                           [Signature page follows.]

                                     A-118
<PAGE>

   IN WITNESS WHEREOF, the parties hereto have duly executed this Agreement, as
of the date first above written.

                                          PROMEDIX.COM, INC.

                                          By: _________________________________
                                          Name:
                                          Title:

                                          CHEMDEX CORPORATION

                                          By: _________________________________
                                          Name:
                                          Title:

                                     A-119
<PAGE>

STATE OF UTAH       )
                    ) ss
COUNTY OF           )

   On       , before me,        , Notary Public, personally appeared
              , personally known to me (or proved to me on the basis of
satisfactory evidence) to be the person(s) whose name(s) is/are subscribed to
the within instrument and acknowledged to me that he/she/they executed the same
in his/her/their authorized capacity(ies), and that by his/her/their
signature(s) on the instrument the person(s), or the entity upon behalf of
which the person(s) acted, executed the instrument.

   WITNESS my hand and official seal.

                                          ---------------------
                                          Signature

[SEAL]

                                     A-120
<PAGE>

STATE OF UTAH          )
                       ) ss
COUNTY OF              )

   On            , before me,               , Notary Public, personally
appeared                            , personally known to me (or proved to me
on the basis of satisfactory evidence) to be the person(s) whose name(s) is/are
subscribed to the within instrument and acknowledged to me that he/she/they
executed the same in his/her/their authorized capacity(ies), and that by
his/her/their signature(s) on the instrument the person(s), or the entity upon
behalf of which the person(s) acted, executed the instrument.

   WITNESS my hand and official seal.

                                          ---------------------
                                          Signature

[SEAL]

                                     A-121
<PAGE>

                                   SCHEDULE A

                         Issued U.S. Patents of Debtor

<TABLE>
<CAPTION>
Patent No.               Issue Date                            Inventor                           Title
- ----------               ----------                            --------                           -----
<S>                      <C>                                   <C>                                <C>

                   Pending U.S. Patent Applications of Debtor

<CAPTION>
Serial No.               Filing Date                           Inventor                           Title
- ----------               -----------                           --------                           -----
<S>                      <C>                                   <C>                                <C>
</TABLE>

                                     A-122
<PAGE>

                                   SCHEDULE B

                           U.S. Trademarks of Debtor

<TABLE>
<CAPTION>
Registration No.    Registration Date     Filing Date     Registered Owner     Mark
- ----------------    -----------------     -----------     ----------------     ----
<S>                 <C>                   <C>             <C>                  <C>
</TABLE>

                 Pending U.S. Trademark Applications of Debtor

<TABLE>
<CAPTION>
Application No.             Filing Date                       Applicant                       Mark
- ---------------             -----------                       ---------                       ----
<S>                         <C>                               <C>                             <C>
</TABLE>

                                     A-123
<PAGE>

                                   EXHIBIT H

                      FULFILLMENT BUSINESS SALE DOCUMENTS

                                     A-124
<PAGE>

                                                             September    , 1999

Mr. William C. Klintworth, Jr.
c/o Promedix.com, Inc.
488 E. Winchester, Suite 200
Salt Lake City, UT 84107

                                Letter Agreement

Dear Skip:

   This letter of intent and the attached term sheet set forth the principal
business points for the acquisition by you and potentially other stockholders
of Promedix.com, Inc. (the "Company") of the Company's wholly-owned subsidiary,
Pro Med Co., Inc. ("Sub").

     1. Sale of Subsidiary. On the terms and conditions set forth below and
  in the attached term sheet, the Company will sell (the "Spin-Off") 100% of
  the outstanding capital stock of Sub to William C. Klintworth, Jr. and such
  other stockholders of the Company as shall indicate an interest to purchase
  a pro-rata portion of the equity interests in the Sub. In the event that no
  other stockholder of the Company elects to purchase shares of the Sub, Mr.
  Klintworth will purchase all of such shares on the terms set forth herein.

     2. Offering to Company Stockholders. Promptly following execution of
  this Letter Agreement, the Company will provide each of its stockholders of
  record as of the date of this Letter Agreement with an opportunity to
  participate as a purchaser in the Spin-Off on a pro-rata basis, determined
  with reference to the number of shares of capital stock held by each such
  stockholder.

     3. Effect and Enforceability of Letter. This letter of intent is a
  binding agreement, which the parties anticipate will be superseded by
  additional documentation memorializing the agreement set forth herein. The
  parties will use their best efforts to negotiate in good faith agreements
  containing the terms set forth in this letter of intent and in the attached
  term sheet and other appropriate terms, representations, warranties and
  covenants for transactions of this kind.

     4. Governing Law; Counterparts. This Letter Agreement and all acts and
  transactions pursuant hereto shall be governed, construed and interpreted
  in accordance with the laws of the State of California, without giving
  effect to principles of conflicts of law.

   This Letter Agreement may be executed in counterparts, each of which shall
be considered an original, and when taken together shall be considered one
instrument.

                                          Sincerely,

                                          PROMEDIX.COM, INC.

                                          By: _________________________________
                                          Barrie Keiser, President

                                          AGREED AND ACCEPTED:

                                          -------------------------------------
                                          William C. Klintworth, Jr.

                                     A-125
<PAGE>

                         SPIN-OFF OF PRO MED CO., INC.

                                   Term Sheet

   The following sets forth the principal terms upon which Promedix.com, Inc.
(the "Company") will sell its wholly-owned subsidiary, Pro Med Co., Inc.
("Sub") to William C. Klintworth and potentially other stockholders of the
Company (the "Purchasers"). This term sheet is attached to and incorporated
into a Letter Agreement between the parties dated as of September   , 1999.
Capitalized terms used herein have the meanings given them in the Letter
Agreement to which this Term Sheet is attached.

<TABLE>
<S>                                <C>
Structure:........................  Promedix.com, Inc. (the "Company") will sell 100% of
                                    the outstanding capital stock of its wholly-owned
                                    subsidiary, Pro Med Co., Inc. (the "Sub") to William
                                    C. Klintworth and such other stockholders of the
                                    Company as shall indicate an interest to purchase a
                                    pro-rata portion of the equity interests in the Sub.
Assets:...........................  Sub's principal assets and liabilities include (and
                                    will include at the time of the closing of the
                                    transaction contemplated by this Term Sheet), those
                                    assets and liabilities listed on Schedule A to this
                                    Term Sheet.
Purchase Price:...................  The purchase price will equal the current fair market
                                    value of the Sub, as determined by a reputable
                                    appraiser selected by the Company. The purchase price
                                    shall consist of secured promissory notes in a form
                                    acceptable to the Company (the "Notes").
Terms of the Notes:...............  Balloon note due December 31, 2005. Interest to accrue
                                    from September 2000 at a rate of 8% per annum.
                                    Interest only payments commence July 1, 2002, and will
                                    be made every six months thereafter. Standard
                                    covenants and restrictions on borrowing shall apply.
                                    Notes shall be full recourse and secured by the shares
                                    of capital stock of Sub held by the purchasers.
Other Terms:......................  Normal and customary terms, including representations
                                    and warranties, securities law compliance and standard
                                    closing conditions.
Closing Date:.....................  The parties anticipate the closing will occur after
                                    adequate notice and opportunity to participate in the
                                    Spin-Off has been provided to the Company's
                                    stockholders.
Expenses:.........................  The Company shall reimburse the Purchasers for the
                                    reasonable fees of one counsel to the Purchasers.
Right of First Refusal:...........  In the event that, at any time within 3 years of the
                                    closing of the Spin-Off, Sub elects to merge or sell
                                    Sub or substantially all of the assets of Sub to a
                                    third party, the Company shall have a right of first
                                    refusal to acquire Sub on the same terms of such
                                    proposed transaction, such right of first refusal to
                                    be exercised within 30 days following its receipt of
                                    notice of such proposed transaction.
Operational Agreement:............  Sub will enter into an Intermediary Supplier Agreement
                                    with Promedix pursuant to which Promedix will have the
                                    right to purchase products from Sub for at least 7%
                                    off of Sub's suggested retail price.
</TABLE>

                                     A-126
<PAGE>

                                   SCHEDULE A

                  Assets and Liabilities of Pro Med Co., Inc.

                           [to come from the Company]

                                     A-127
<PAGE>

                                   EXHIBIT H

                SUBJECT MATTER OF OPINION OF COUNSEL TO ACQUIROR

   All capitalized terms used herein and not otherwise defined have the
meanings given them in the Agreement and Plan of Merger dated as of September
21, 1999 (the "Merger Agreement"), by and among Chemdex Corporation, a Delaware
corporation ("Acquiror"), Popcorn Acquisitions Corp., a Delaware corporation
and wholly-owned subsidiary of Acquiror ("Sub"), and Promedix, a Delaware
corporation ("Target").

     (1) Acquiror is a corporation duly organized, validly existing and in
  good standing under the laws of the State of Delaware, has all requisite
  corporate power to own, lease and operate its property and to carry on its
  business as now being conducted.

     (2) The shares of Acquiror's Common Stock to be issued pursuant to the
  Merger will be duly authorized, validly issued, fully paid, and non-
  assessable and no person will have any preemptive right of subscription or
  purchase in respect thereof.

     (3) Acquiror has all requisite corporate power and authority to enter
  into the Merger Agreement and the Certificate of Merger, and to consummate
  the transactions contemplated thereby. The Merger Agreement and the
  Certificate of Merger are collectively referred to herein as the "Opinion
  Documents." The execution and delivery of the Opinion Documents and the
  consummation of the transactions contemplated thereby have been duly
  authorized by all necessary corporate action on the part of Acquiror. The
  Opinion Documents have been duly and validly executed and delivered by
  Acquiror and, assuming due execution and delivery by the other parties
  thereto, constitute the valid and binding obligations of Acquiror,
  enforceable against Acquiror in accordance with their respective terms.

     (4) The execution and delivery by Acquiror of the Opinion Documents and
  the consummation of the transactions contemplated thereby will not, (i)
  result in any violation or breach of any provision of the Certificate of
  Incorporation, or any Certificate of Designation thereunder, or Bylaws of
  Acquiror, or (ii) to our knowledge, violate any permit, concession,
  franchise, license, judgment, order, decree, statute, law, ordinance, rule
  or regulation applicable to Target or any of its properties or assets.

     (5) No consent, approval, order or authorization of, or registration,
  declaration or filing with, any Governmental Entity is required on the part
  of Acquiror in connection with the execution and delivery of the Opinion
  Documents or the consummation of the transactions contemplated thereby,
  except for (i) the filing of the Certificate of Merger with the Secretary
  of State of the State of Delaware, (ii) filings required under the Hart-
  Scott Rodino Antitrust Improvement Act of 1976, as amended, (iii) such
  consents, approvals, orders, authorizations, registrations, declarations
  and filings as may be required under applicable federal and state
  securities laws and the laws of any foreign country, and (iv) such other
  consents, authorizations, filings, approvals and registrations which, if
  not obtained or made, could not be expected to have a Material Adverse
  Effect on Acquiror.


                                     A-128
<PAGE>

                                   EXHIBIT I

                  SUBJECT MATTER OF OPINION OF CHEMDEX COUNSEL

                                     A-129
<PAGE>

                                                                         ANNEX B

                                ESCROW AGREEMENT

   THIS ESCROW AGREEMENT (this "Agreement") is entered into as of September 21,
1999, by and among Chemdex Corporation, a Delaware corporation ("Chemdex"),
Promedix.com, Inc., a Delaware corporation ("Promedix"), U.S. Bank Trust,
National Association, as Escrow Agent ("Escrow Agent"), and Skip Klintworth and
Brad Bond, as Stockholders' Agents ("Stockholders' Agents") with respect to the
shares of Chemdex capital stock to be issued to the former Promedix
Stockholders (collectively, the "Holders") in the Merger (as defined below).

                                    RECITALS

   A. Chemdex, Promedix, and Promedix Acquisition Corp., a Delaware corporation
and wholly-owned subsidiary of Chemdex ("Sub"), have entered into a Agreement
and Plan of Merger dated as of September 21, 1999 (the "Merger Agreement"),
pursuant to which Sub will merge with and into Promedix (the "Merger"), with
Promedix surviving the Merger as the surviving corporation. Capitalized terms
used in this Agreement and not otherwise defined in this Agreement shall have
the meanings given them in the Merger Agreement.

   B. Section 2.2 of the Merger Agreement provides that at the Effective Time,
or such later time as determined in accordance with Section 2.3(b) of the
Merger Agreement with respect to Dissenting Shares for which dissenters' rights
shall have been withdrawn or lost, Chemdex will deposit in escrow (such deposit
constituting the "Escrow Fund") certificates representing an aggregate of
12,057,366 shares of Chemdex Common Stock issuable to the Holders in the
Merger, on a pro rata basis, in accordance with each Holder's percentage
ownership of Chemdex Common Stock issuable pursuant to the Merger. Pursuant to
the Merger Agreement, (i) ninety percent (90%) of such shares (the "Locked Up
Shares") shall be held in escrow on behalf of the holders until January 22,
2000, but not held as security for Promedix's indemnification obligations under
Article X of the Merger Agreement; and (ii) ten percent (10%) of such shares
(the "Escrow Shares") shall be held as security for Promedix's indemnification
obligations under Article X of the Merger Agreement and shall represent
Chemdex's sole and exclusive remedy with respect to such indemnification
obligations, except for damages based upon a claim of fraud. The Locked Up
Shares and Escrow Shares are collectively referred to herein as the "Escrow
Securities."

   C. The parties to this Agreement desire to establish the terms and
conditions pursuant to which the Escrow Securities will be deposited, held in,
and disbursed from the Escrow Fund.

                                   AGREEMENT

   NOW, THEREFORE, the parties to this Agreement agree as follows:

     1. Escrow Fund. The Escrow Agent agrees to: (a) accept delivery of the
  Escrow Securities; and (b) hold such Escrow Securities in escrow as part of
  the Escrow Fund, all subject to the terms and conditions of this Agreement
  and Section 2.2 and Article X of the Merger Agreement (which Section 2.2
  and Article X are attached to this Agreement as Appendix I and incorporated
  by reference into this Agreement) (collectively, the "Escrow Provisions").
  The Escrow Securities will include "Additional Escrow Securities" as that
  term is defined in Section 2(c) of this Agreement.

     2. Deposit of Escrow Securities: Release from Escrow.

       (a) Delivery of Escrow Securities. As soon as practicable after the
    Effective Time, the Escrow Securities will be delivered by Chemdex on
    behalf of the Holders to the Escrow Agent. Such shares shall be issued
    in the name of the Escrow Agent. In the event Chemdex issues any
    Additional Escrow Securities, such Escrow Securities will be issued in
    the name of the Escrow Agent and delivered to the Escrow Agent in the
    same manner as the Escrow Securities.


                                      B-1
<PAGE>

       (b) Holders' Accounts. The Escrow Agent will maintain for each
    Holder an accounting record (each Holder's "Account") specifying the
    Escrow Securities held for the record of each Holder pursuant to the
    Escrow Provisions. All Escrow Securities received under Section 2(a)
    will be allocated to each Holder's Account in accordance with such
    Holder's percentage interest in the Escrow Fund as set forth on
    Appendix II.

       (c) Dividends, Voting and Rights of Ownership. Except for tax-free
    dividends paid in stock declared with respect to the Escrow Securities
    pursuant to Section 305(a) of the Internal Revenue Code of 1986, as
    amended (the "Code") ("Additional Escrow Securities"), there will be
    distributed promptly to the Holders any cash dividends or dividends
    payable in securities or other distributions of any kind made in
    respect of the Escrow Securities. Each Holder will have voting rights
    with respect to the Escrow Securities deposited in the Escrow Fund with
    respect to such Holder so long as such Escrow Securities are held in
    escrow, and Chemdex will take all reasonable steps necessary to allow
    the exercise of such rights. While the Escrow Securities remain in the
    Escrow Agent's possession pursuant to this Agreement and the Merger
    Agreement, the Holders will retain and will be able to exercise all
    other incidents of ownership of said Escrow Securities which are not
    inconsistent with the terms and conditions of this Agreement and the
    Merger Agreement.

       (d) Release. The Locked Up Shares will be held by the Escrow Agent
    until January 22, 2000. The Locked Up Shares shall not be subject to,
    or held as security for, Promedix's indemnification obligations under
    Article X of the Merger Agreement. The Escrow Shares will be held by
    the Escrow Agent until required to be released to the Holders pursuant
    to Section 10.3 of the Merger Agreement, unless previously delivered to
    Chemdex pursuant to Section 10.4 of the Merger Agreement. Within five
    (5) business days after the applicable release condition is met, the
    Escrow Agent will deliver to each Holder the Escrow Securities to be
    released on such date as identified by Chemdex and the Stockholders'
    Agents to the Escrow Agent in writing. Escrow Securities will be in the
    form of stock certificate(s) issued in the name of such Holder. Chemdex
    and the Stockholders' Agents will undertake to deliver a notice to the
    Escrow Agent identifying the number of Escrow Securities to be released
    with respect to each Holder within such five-day period. Escrow
    Securities will be released to the respective Holders in accordance
    with their respective Accounts. Chemdex will take such action as may be
    necessary to cause such certificates to be issued in the names of the
    appropriate Holders. Cash will be paid in lieu of fractions of Escrow
    Securities in an amount equal to the product determined by multiplying
    such fraction by $        (the "Per Share Value"). Within five (5)
    business days after written request from the Stockholders' Agents,
    Chemdex will deposit with the Escrow Agent sufficient funds to pay such
    cash amounts for fractional shares.

       (e) No Encumbrance. Except as provided in this Agreement and as may
    be set forth in the Target Disclosure Schedule, no Escrow Securities or
    any beneficial interest in the Escrow Securities may be pledged, sold,
    assigned or transferred, including by operation of law, by a Holder or
    be taken or reached by any legal or equitable process in satisfaction
    of any debt or other liability of a Holder, prior to the delivery to
    such Holder of the Escrow Securities by the Escrow Agent.

       (f) Power to Transfer Escrow Securities. The Escrow Agent is granted
    the power to effect any transfer of Escrow Securities contemplated by
    the Escrow Provisions. Chemdex will cooperate with the Escrow Agent in
    promptly issuing stock certificates to effect such transfers.

       (g) Reporting. Each Holder will provide the Escrow Agent with
    his/her/its Taxpayer Identification Number at or prior to Closing. On
    or before January 31 of each year under this Agreement, the Escrow
    Agent will prepare and mail to each Holder, other than Holders who
    demonstrate their status as non-resident aliens in accordance with the
    United States Treasury Regulations, a Form 1099-B reporting any cash
    payments, in accordance with such Treasury Regulations. The Escrow
    Agent will also prepare and file copies of such Forms 1099-B by
    magnetic tape with the IRS, in accordance with Treasury Regulations. If
    the Escrow Agent has not received notice from a Holder of such Holder's
    certified Taxpayer Identification Number, the Escrow Agent

                                      B-2
<PAGE>

    shall deduct and withhold backup withholding tax from any cash payment
    made pursuant to the Internal Revenue Code and applicable regulations
    thereunder. Should any issue arise regarding federal income tax
    reporting or withholding, the Escrow Agent shall act in accordance with
    the written instructions of the Stockholders' Agents and Chemdex.

     3. Limitation of the Escrow Agent's Liability.

       (a) The Escrow Agent will incur no liability with respect to any
    action taken or suffered by it in reliance upon any notice, direction,
    instruction, consent, statement or other document believed by it to be
    genuine and duly authorized, nor for any other action or inaction,
    except its own willful misconduct, bad faith or gross negligence. The
    Escrow Agent will not be responsible for the validity or sufficiency of
    the Escrow Provisions. In all questions arising under the Escrow
    Provisions, the Escrow Agent may rely on the advice of counsel, and for
    anything done, omitted or suffered in good faith by the Escrow Agent
    based on such advice, the Escrow Agent will not be liable to anyone.
    The Escrow Agent will not be required to take any action under the
    Escrow Provisions involving any expense unless the payment of such
    expense is made or provided for in a manner satisfactory to it.

       (b) In the event conflicting demands are made or notices are served
    upon the Escrow Agent with respect to the Escrow Fund, the Escrow Agent
    will have the absolute right, at the Escrow Agent's election, to do
    either or both of the following: resign so a successor can be appointed
    pursuant to Section 5 or file a suit in interpleader and obtain an
    order from a court of competent jurisdiction requiring the parties to
    interplead and litigate in such court their several claims and rights
    among themselves. In the event such interpleader suit is brought, the
    Escrow Agent will thereby be fully released and discharged from all
    further obligations imposed upon it under the Escrow Provisions, and
    Chemdex will pay the Escrow Agent (subject to reimbursement from the
    Holders pursuant to Section 4) all costs, expenses and reasonable
    attorney's fees expended or incurred by the Escrow Agent pursuant to
    the exercise of the Escrow Agent's rights under this Section 3 (such
    costs, fees and expenses will be treated as extraordinary fees and
    expenses for the purposes of Section 4).

     4. Expenses.

       (a) Escrow Agent. All fees and expenses of the Escrow Agent incurred
    in the ordinary course of performing its responsibilities hereunder
    will be paid by Chemdex upon receipt of a written invoice by the Escrow
    Agent. Any extraordinary fees and expenses, including without
    limitation any fees or expenses incurred by the Escrow Agent in
    connection with a dispute over the distribution of Escrow Securities or
    the validity of a claim or claims by Chemdex made in an Officer's
    Certificate, will be paid 50% by Chemdex and 50% by the Holders. The
    Holders' liability for the extraordinary fees and expenses of the
    Escrow Agent may be paid by Chemdex and recovered as a claim hereunder
    out of the Escrow Fund. If Chemdex has paid the Holders' portion of
    such fees and expenses as permitted under this Section 4(a), then the
    Escrow Agent will, upon demand by Chemdex, transfer to Chemdex a number
    of Escrow Securities having an aggregate Per Share Value equal to such
    portion of fees and expenses.

       In the event the balance in the Escrow Fund is not sufficient to pay
    the extraordinary fees and expenses of the Escrow Agent, as described
    in the prior paragraph, or in the event the Escrow Agent incurs any
    liability to any person, firm or corporation by reason of its
    acceptance or administration of this Escrow Agreement, the other
    parties hereto, jointly and severally, agree to indemnify the Escrow
    Agent for its extraordinary fees and expenses or costs and expenses,
    including, without limitation, counsel fees and expenses, as the case
    may be. Notwithstanding the foregoing, no indemnity need be paid in the
    event of the Escrow Agent's gross negligence, bad faith or willful
    misconduct.

       (b) Stockholders' Agents. The Stockholders' Agents will not be
    entitled to receive any compensation from Chemdex or the Holders in
    connection with this Agreement. Any fees and expenses incurred by the
    Stockholders' Agents in connection with actions taken pursuant to the
    terms of the Escrow Provisions will be paid by the Holders.

                                      B-3
<PAGE>

     5. Successor Escrow Agent. In the event the Escrow Agent becomes
  unavailable or unwilling to continue in its capacity as such, the Escrow
  Agent may resign and be discharged from its duties or obligations hereunder
  by giving resignation to the parties to this Agreement, specifying not less
  than thirty (30) days' prior written notice of such a date when such
  resignation will take effect. Chemdex will designate a successor Escrow
  Agent prior to the expiration of such 30-day period by giving written
  notice to the Escrow Agent and the Stockholders' Agents. Chemdex may
  appoint a successor Escrow Agent with the consent of the Stockholders'
  Agents, which will not be unreasonably withheld. The Escrow Agent will
  promptly transfer the Escrow Securities to such designated successor. In
  the event no successor Escrow Agent is appointed as described in this
  Section 5, the Escrow Agent may apply to a court of competent jurisdiction
  for the appointment of a successor Escrow Agent.

     6. Limitation of Responsibility. The Escrow Agent's duties are limited
  to those set forth in the Escrow Provisions and the Escrow Agent may rely
  upon the written notices delivered to the Escrow Agent under the Escrow
  Provisions.

     7. Incorporation by Reference of Article X. The parties agree that the
  terms of Section 2.2 and Article X of the Merger Agreement shall be deemed
  to be incorporated by reference in this Agreement as if such Article had
  been set forth in its entirety herein. The parties acknowledge that the
  administration of the Escrow Fund by the Escrow Agent will require
  reference to both the terms of this Agreement as well as the terms of such
  Article X.

     8. Notices. Any notice provided for or permitted under the Escrow
  Provisions will be treated as having been given when (i) delivered
  personally, (ii) sent by confirmed telex or Fax, (iii) sent by commercial
  overnight courier with written verification of receipt, or (iv) mailed
  postage prepaid by certified or registered mail, return receipt requested,
  to the party to be notified, at the address set forth below, or at such
  other place of which the other party has been notified in accordance with
  the provisions of this Section 8.

     Escrow Agent:      U.S. Bank Trust, National Association
                        One California Street, 4th Floor
                        San Francisco, California 94111
                        Attention: Ann Gadsby
                        Fax No: (415) 273-4593
                        Telephone No: (415) 273-4532
     Stockholders' Agents:
                        Promedix, Inc.
                        448 East Winchester Avenue, Suite 200
                        Salt Lake City, Utah 84107
                        Attention: Skip Klintworth
                        Brad Bond
                        Fax No: (801) 261-7475
                        Telephone No: (800) 453-1264

     With copy to:      Orrick, Herrington & Sutcliffe LLP
                        1020 Marsh Road
                        Menlo Park, CA 94025
                        Attention: Geoffrey P. Leonard, Esq.
                        Fax No: (650) 614-7401
                        Telephone No: (650) 614-7470

     Chemdex:           Chemdex Corporation
                        3950 Fabian Way
                        Palo Alto, CA 94308
                        Attention: Chief Executive Officer
                        Fax No: (650) 813-0304
                        Telephone No: (650) 813-0300

                                      B-4
<PAGE>

     With copy to:      Venture Law Group
                        A Professional Corporation
                        2775 Sand Hill Road
                        Menlo Park, California 94025
                        Attention: Jeffrey Y. Suto
                        Fax No: (650) 233-8386
                        Telephone No: (650) 854-4488

   Such notice will be treated as having been received upon actual receipt.

     9. General.

       (a) Governing Laws. It is the intention of the parties hereto that
    the internal laws of the State of Delaware (irrespective of its choice
    of law principles) shall govern the validity of this Agreement, the
    construction of its terms, and the interpretation and enforcement of
    the rights and duties of the parties to this Agreement.

       (b) Binding upon Successors and Assigns. Subject to, and unless
    otherwise provided in, this Agreement, each and all of the covenants,
    terms, provisions, and agreements contained in this Agreement shall be
    binding upon, and inure to the benefit of, the permitted successors,
    executors, heirs, representatives, administrators and assigns of the
    parties to this Agreement.

       (c) Counterparts. This Agreement may be executed in any number of
    counterparts, each of which shall be an original as against any party
    whose signature appears on such counterpart and all of which together
    shall constitute one and the same instrument. This Agreement shall
    become binding when one or more counterparts of this Agreement,
    individually or taken together, shall bear the signatures of all of the
    parties reflected in this Agreement as signatories.

       (d) Entire Agreement. Except as set forth in the Merger Agreement,
    this Agreement, the documents referenced in this Agreement and the
    exhibits to such documents, constitute the entire understanding and
    agreement of the parties to this Agreement with respect to the subject
    matter of this Agreement and of such documents and exhibits and
    supersede all prior and contemporaneous agreements or understandings,
    inducements or conditions, express or implied, written or oral, between
    the parties with respect to this Agreement. The express terms of this
    Agreement control and supersede any course of performance or usage of
    the trade inconsistent with any of the terms of this Agreement.

       (e) Waivers. No waiver by any party to this Agreement of any
    condition or of any breach of any provision of this Agreement will be
    effective unless in writing. No waiver by any party of any such
    condition or breach, in any one instance, will be deemed to be a
    further or continuing waiver of any such condition or breach or a
    waiver of any other condition or breach of any other provision
    contained in this Agreement.

       (f) Amendment. This Agreement may be amended with the written
    consent of Chemdex, the Escrow Agent and the Stockholders' Agents;
    provided, however, that if the Escrow Agent does not agree to an
    amendment agreed upon by Chemdex and the Stockholders' Agents, a
    successor Escrow Agent will be appointed in accordance with Section 5.

                            [Signature Page Follows]

                                      B-5
<PAGE>

   IN WITNESS WHEREOF, the parties have duly executed this Escrow Agreement as
of the day and year first written above and will be effective as to all the
Holders when executed by Chemdex, the Escrow Agent and the Stockholders'
Agents.

                                          CHEMDEX CORPORATION

                                          By: _________________________________

                                          Its: ________________________________

                                          PROMEDIX.COM, INC.

                                          By: _________________________________

                                          Its: ________________________________

                                          ESCROW AGENT:

                                          U.S. BANK TRUST, NATIONAL
                                           ASSOCIATION

                                          By: _________________________________

                                          Its: ________________________________

                                          STOCKHOLDERS' AGENTS:

                                          _____________________________________
                                          Skip Klintworth

                                          _____________________________________
                                          Brad Bond


                                      B-6
<PAGE>

                                                                         ANNEX C

                                                              September 21, 1999

Board of Directors
Chemdex Corporation
3950 Fabian Way
Palo Alto, CA 94303

Members of the Board of Directors:

   We understand that Chemdex Corporation ("Chemdex"), Promedix.com, Inc.
("Promedix.com"), and Popcorn Acquisitions Corp. ("Merger Sub"), a wholly-owned
subsidiary of Chemdex, propose to enter into an Agreement and Plan of Merger,
substantially in the form of the draft dated as of September 16, 1999 (the
"Merger Agreement"), which provides, among other things, for the merger (the
"Merger") of Merger Sub with and into Promedix.com. Pursuant to the Merger,
Promedix.com will become a wholly-owned subsidiary of Chemdex and each
outstanding share of common stock, par value $0.0001, of Promedix.com (the
"Promedix.com Common Stock"), or Series A , Series B-1 or Series B-2 Preferred
Stock, each with a par value of $0.0001 per share, of Promedix.com
(collectively, the "Preferred Stock"), other than shares held in treasury or
held by Chemdex or any affiliate of Chemdex or Promedix.com or as to which
dissenters' rights have been perfected, will be converted into the right to
receive in the aggregate 12,057,366 shares of common stock, par value $0.0002
per share, of Chemdex (the "Chemdex Common Stock"), determined pursuant to a
certain formula set forth in the Merger Agreement (collectively, the
"Consideration"). The terms and conditions of the Merger are more fully set
forth in the Merger Agreement.

   You have asked for our opinion as to whether the Consideration to be paid by
Chemdex pursuant to the Merger Agreement is fair from a financial point of view
to Chemdex.

   For purposes of the opinion set forth herein, we have, among other things:

  (i) reviewed certain publicly available financial statements and other
      information of Chemdex;

  (ii) analyzed certain financial projections relating to Promedix.com
       prepared by the management of Promedix.com;

  (iii) reviewed certain internal financial statements and other financial
        and operating data concerning Chemdex and Promedix.com prepared by
        the managements of Chemdex and Promedix.com, respectively;

  (iv) discussed the past and current operations and financial condition and
       the prospects of Promedix.com, including information relating to
       certain strategic, financial and operational benefits anticipated from
       the Merger, with senior executives of Promedix.com;

  (v) discussed the past and current operations and financial condition and
      the prospects of Chemdex, including information relating to certain
      strategic, financial and operational synergies and benefits anticipated
      from the Merger, with senior executives of Chemdex;

  (vi) reviewed the pro forma impact of the Merger on the earnings per share
       and balance sheet of Chemdex;

  (vii) reviewed the reported prices and trading activity of the Chemdex
        Common Stock;

  (viii) reviewed the stock prices and trading activity of certain other
         publicly-traded companies comparable to Promedix.com and Chemdex;

                                      C-1
<PAGE>

Members of the Board of Directors
September 21, 1999
Page 2


  (ix) reviewed the financial terms, to the extent publicly available, of
       certain comparable acquisition transactions;

  (x) reviewed and discussed with the senior managements of Chemdex and
      Promedix.com the strategic rationale for the Merger;

  (xi) participated in negotiations and discussions among representatives of
       Chemdex and Promedix.com and their legal advisors;

  (xii) reviewed the draft Merger Agreement and certain related documents;
        and

  (xiii) performed such other analysis and considered such other factors as
      we have deemed appropriate.

   We have assumed and relied upon, without independent verification, the
accuracy and completeness of the information reviewed by us for the purposes of
this opinion. With respect to the internal financial statements and other
financial and operating data and estimates of the strategic, financial and
operational benefits anticipated from the Merger provided by Chemdex and
Promedix.com, we have assumed that they have been reasonably prepared on bases
reflecting the best currently available estimates and judgments of the
prospects of Chemdex and Promedix.com, respectively. We have relied upon the
assessment by the managements of Chemdex and Promedix.com of their ability to
retain key employees of Promedix.com. We have also relied upon, without
independent verification, the assessment by the managements of Chemdex and
Promedix.com of: (i) the strategic and other benefits expected to result from
the Merger; (ii) Promedix.com's technologies, products and intellectual
property; (iii) the timing and risks associated with the integration of Chemdex
and Promedix.com; and (iv) the validity of, and risks associated with,
Chemdex's and Promedix.com's existing and future technologies, products and
intellectual property. We have not made any independent valuation or appraisal
of the assets, liabilities, technologies and intellectual property of
Promedix.com, nor have we been furnished with any such appraisals. In addition,
we have assumed that the Merger will be treated as a tax-free reorganization
pursuant to the Internal Revenue Code of 1986 and will be consummated in
accordance with the terms set forth in the Merger Agreement. Our opinion is
necessarily based on financial, economic, market and other conditions as in
effect on, and the information made available to us as of, the date hereof.

   We have acted as financial advisor to the Board of Directors of Chemdex in
connection with this transaction and will receive a fee for our services. In
the past, Morgan Stanley & Co. Incorporated and its affiliates have provided
financing services for Chemdex and have received fees for the rendering of
these services. In addition, in the ordinary course of our business we may
actively trade the securities of Chemdex for our own account and for the
accounts of our customers and, accordingly, may at any time hold a long or
short position in such securities.

   It is understood that this letter is for the information of the Board of
Directors of Chemdex and may not be used for any other purpose without our
prior written consent, except that this opinion may be included in its entirety
in any filing made by Chemdex with the Securities and Exchange Commission in
respect of the transaction. In addition, this opinion does not in any manner
address the prices at which the Chemdex Common Stock will trade following the
consummation of the Merger, and we express no opinion or recommendation as to
how the stockholders of Chemdex Common Stock should vote at the shareholder
meeting held in connection with the Merger.

                                      C-2
<PAGE>

Members of the Board of Directors
September 21, 1999
Page 3


   Based upon and subject to the foregoing, we are of the opinion on the date
hereof that the Consideration to be paid by Chemdex pursuant to the Merger
Agreement is fair from a financial point of view to Chemdex.

                                          Very truly yours,

                                          MORGAN STANLEY & CO. INCORPORATED


                                          By:__________________________________
                                            Geoffrey D. Baldwin
                                            Principal

                                      C-3
<PAGE>

                                                                         ANNEX D

                     DELAWARE DISSENTERS' RIGHTS PROVISIONS

   262 APPRAISAL RIGHTS.--(a) Any stockholder of a corporation of this State
who holds shares of stock on the date of the making of a demand pursuant to
subsection (d) of this section with respect to such shares, who continuously
holds such shares through the effective date of the merger or consolidation,
who has otherwise complied with subsection (d) of this section and who has
neither voted in favor of the merger or consolidation nor consented thereto in
writing pursuant to (S) 228 of this tittle shall be entitled to an appraisal by
the Court of Chancery of the fair value of the stockholder's shares of stock
under the circumstances described in subsections (b) and (c) of this section.
As used in this section, the word "stockholder" means a holder of record of
stock in a stock corporation and also a member of record of a nonstock
corporation; the words "stock" and "share" mean and include what is ordinarily
meant by those words and also membership or membership interest of a member of
a nonstock corporation; and the words "depository receipt" mean a receipt or
other instrument issued by a depository representing an interest in one or more
shares, or fractions thereof, solely of stock of a corporation, which stock is
deposited with the depository.

   (b) Appraisal rights shall be available for the shares of any class or
series of stock of a constituent corporation in a merger or consolidation to be
effected pursuant to (S) 251 (other than a merger effected pursuant to (S)
251(g) of this title), (S) 252, (S) 254, (S) 257, (S) 258, (S) 263 or (S) 264
of this title:

     (1) Provided, however, that no appraisal rights under this section shall
  be available for the shares of any class or series of stock, which stock,
  or depository receipts in respect thereof, at the record date fixed to
  determine the stockholders entitled to receive notice of and to vote at the
  meeting of stockholders to act upon the agreement of merger or
  consolidation, were either (i) listed on a national securities exchange or
  designated as a national market system security on an interdealer quotation
  system by the National Association of Securities Dealers, Inc. or (ii) held
  of record by more than 2,000 holders; and further provided that no
  appraisal rights shall be available for any shares of stock of the
  constituent corporation surviving a merger if the merger did not require
  for its approval the vote of the stockholders of the surviving corporation
  as provided in subsection (f) of (S) 251 of this title.

     (2) Notwithstanding paragraph (1) of this subsection, appraisal rights
  under this section shall be available for the shares of any class or series
  of stock of a constituent corporation if the holders thereof are required
  by the terms of an agreement of merger or consolidation pursuant to (S)(S)
  251, 252, 254, 257, 258, 263 and 264 of this title to accept for such stock
  anything except:

       a. Shares of stock of the corporation surviving or resulting from
    such merger or consolidation, or depository receipts in respect
    thereof;

       b. Shares of stock of any other corporation, or depository receipts
    in respect thereof, which shares of stock (or depositary receipts in
    respect thereof) or depository receipts at the effective date of the
    merger or consolidation will be either listed on a national securities
    exchange or designated as a national market system security on an
    interdealer quotation system by the National Association of Securities
    Dealers, Inc. or held of record by more than 2,000 holders;

       c. Cash in lieu of fractional shares or fractional depository
    receipts described in the foregoing subparagraphs a. and b. of this
    paragraph; or

       d. Any combination of the shares of stock, depository receipts and
    cash in lieu of fractional shares or fractional depository receipts
    described in the foregoing subparagraphs a., b. and c. of this
    paragraph.

     (3) In the event all of the stock of a subsidiary Delaware corporation
  party to a merger effected under (S) 253 of this title is not owned by the
  parent corporation immediately prior to the merger, appraisal rights shall
  be available for the shares of the subsidiary Delaware corporation.

                                      D-1
<PAGE>

   (c) Any corporation may provide in its certificate of incorporation that
appraisal rights under this section shall be available for the shares of any
class or series of its stock as a result of an amendment to its certificate of
incorporation, any merger or consolidation in which the corporation is a
constituent corporation or the sale of all or substantially all of the assets
of the corporation. If the certificate of incorporation contains such a
provision, the procedures of this section, including those set forth in
subsections (d) and (e) of this section, shall apply as nearly as is
practicable.

   (d) Appraisal rights shall be perfected as follows:

     (1) If a proposed merger or consolidation for which appraisal rights are
  provided under this section is to be submitted for approval at a meeting of
  stockholders, the corporation, not less than 20 days prior to the meeting,
  shall notify each of its stockholders who was such on the record date for
  such meeting with respect to shares for which appraisal rights are
  available pursuant to subsections (b) or (c) hereof that appraisal rights
  are available for any or all of the shares of the constituent corporations,
  and shall include in such notice a copy of this section. Each stockholder
  electing to demand the appraisal of /1/ such stockholder's shares shall
  deliver to the corporation, before the taking of the vote on the merger or
  consolidation, a written demand for appraisal of /1/ such stockholder's
  shares. Such demand will be sufficient if it reasonably informs the
  corporation of the identity of the stockholder and that the stockholder
  intends thereby to demand the appraisal of /1/ such stockholder's shares. A
  proxy or vote against the merger or consolidation shall not constitute such
  a demand. A stockholder electing to take such action must do so by a
  separate written demand as herein provided. Within 10 days after the
  effective date of such merger or consolidation, the surviving or resulting
  corporation shall notify each stockholder of each constituent corporation
  who has complied with this subsection and has not voted in favor of or
  consented to the merger or consolidation of the date that the merger or
  consolidation has become effective; or

     (2) If the merger or consolidation was approved pursuant to (S) 228 or
  (S) 253 of this title, each constituent corporation, either before the
  effective date of the merger or consolidation or within ten days
  thereafter, shall notify each of the holders of any class or series of
  stock of such constituent corporation who are entitled to appraisal rights
  of the approval of the merger or consolidation and that appraisal rights
  are available for any or all shares of such class or series of stock of
  such constituent corporation, and shall include in such notice a copy of
  this section; provided that, if the notice is given on or after the
  effective date of the merger or consolidation, such notice shall be given
  by the surviving or resulting corporation to all such holders of any class
  or series of stock of a constituent corporation that are entitled to
  appraisal rights. Such notice may, and, if given on or after the effective
  date of the merger or consolidation, shall, also notify such stockholders
  of the effective date of the merger or consolidation. Any stockholder
  entitle to appraisal rights may, within 20 days after the date of mailing
  of such notice, demand in writing from the surviving or resulting
  corporation the appraisal of such holder's shares. Such demand will be
  sufficient if it reasonably informs the corporation of the identify of the
  stockholder and that the stockholder intends thereby to demand the
  appraisal of such holder's shares. If such notice did not notify
  stockholders of the effective date of the merger or consolidation, either
  (i) each such constituent corporation shall send a second notice before the
  effective date of the merger or consolidation notifying each of the holders
  of any class or series of stock of such constituent corporation that are
  entitled to appraisal rights of the effective date of the merger or
  consolidation or (ii) the surviving or resulting corporation shall send
  such a second notice to all such holders on or within 10 days after such
  effective date; provided, however, that if such second notice is sent more
  than 20 days following the sending of the first notice, such second notice
  need only be sent to each stockholder who is entitled to appraisal rights
  and who has demanded appraisal of such holder's shares in accordance with
  this subsection. An affidavit of the secretary or assistant secretary or of
  the transfer agent of the corporation that is required to give either
  notice that such notice has been given shall, in the absence of fraud, be
  prima facie evidence of the facts stated therein. For purposes of
  determining the stockholders entitled to receive either notice, each
  constituent corporation may fix, in advance, a record date that shall be
  not more than 10 days prior to the date the notice is given, provided, that
  if the notice is given on or after the effective date of the merger or
  consolidation, the record date shall
- --------
/1/Ch. 339, L. "98, eff. 7-1-98, add matter in italic and deleted /1/"his" and
   /2/"he".

                                      D-2
<PAGE>

be such effective date. If no record date is fixed and the notice is given
prior to the effective date, the record date shall be the close of business on
the day next preceding the day on which the notice is given.

   (e) Within 120 days after the effective date of the merger or consolidation,
the surviving or resulting corporation or any stockholder who has complied with
subsections (a) and (d) hereof and who is otherwise entitled to appraisal
rights, may file a petition in the Court of Chancery demanding a determination
of the value of the stock of all such stockholders. Notwithstanding the
foregoing, at any time within 60 days after the effective date of the merger or
consolidation, any stockholder shall have the right to withdraw/1/ such
stockholder's demand for appraisal and to accept the terms offered upon the
merger or consolidation. Within 120 days after the effective date of the merger
or consolidation, any stockholder who has complied with the requirements of
subsections (a) and (d) hereof, upon written request, shall be entitled to
receive from the corporation surviving the merger or resulting from the
consolidation a statement setting forth the aggregate number of shares not
voted in favor of the merger or consolidation and with respect to which demands
for appraisal have been received and the aggregate number of holders of such
shares. Such written statement shall be mailed to the stockholder within 10
days after /1/ such stockholder's written request for such a statement is
received by the surviving or resulting corporation or within 10 days after
expiration of the period for delivery of demands for appraisal under subsection
(d) hereof, whichever is alter.

   (f) Upon the filing of any such petition by a stockholder, service of a copy
thereof shall be made upon the surviving or resulting corporation, which shall
within 20 days after such service file in the office of the Register in
Chancery in which the petition was filed a duly verified list containing the
names and addresses of all stockholders who have demanded payment for their
shares and with whom agreements as to the value of their shares have not been
reached by the surviving or resulting corporation. If the petition shall be
filed by the surviving or resulting corporation, the petition shall be
accompanied by such a duly verified list. The Register in Chancery, if so,
ordered by the Court, shall give notice of the time and place fixed for the
hearing of such petition by registered or certified mail to the surviving or
resulting corporation and to the stockholders shown on the list at the
addresses therein stated. Such notice shall also be given by 1 or more
publications at least 1 week before the day of the hearing, in a newspaper of
general circulation published in the City of Wilmington, Delaware or such
publication as the Court deems advisable. The forms of the notices by mail and
by publication shall be approved by the Court, and the costs thereof shall be
borne by the surviving or resulting corporation.

   (g) At the hearing on such petition, the Court shall determine the
stockholders who have compile with this section and who have become entitled to
appraisal rights. The Court may require the stockholders who have demanded an
appraisal for their shares and who hold stock represented by certificates to
submit their certificates of stock to the Register in Chancery for notation
thereon of the pendency of the appraisal proceedings; and if any stockholder
fails to comply with such direction, the Court may dismiss the proceedings as
to such stockholder.

   (h) After determining the stockholders entitled to an appraisal, the Court
shall appraise the shares, determining their fair value exclusive of any
element of value arising from the accomplishment or expectation of the merger
or consolidation, together with a fair rate of interest, if any, to be paid
upon the amount determined to be the fair value. In determining such fair
value, the Court shall take into account all relevant factors. In determining
the fair rate of interest, the Court may consider all relevant factors,
including the rate of interest which the surviving or resulting corporation
would have had to pay to borrow money during the pendency of the proceeding.
Upon application by the surviving or resulting corporation or by any
stockholder entitled to participate in the appraisal proceeding, the Court may,
in its discretion, permit discovery or other pretrial proceedings and may
proceed to trail upon the appraisal prior to the final determination of the
stockholder entitled to an appraisal. Any stockholder whose name appears on the
list filed by the surviving or resulting corporation pursuant to subsection (f)
of this section and who has submitted /1/ such stockholder's certificates of
stock to the Register in Chancery, if such is required, may participate fully
in all proceedings until it is finally determined that /2/ such stockholder is
not entitled to appraisal rights under this section.
- --------
/1/Ch. 339, L. "98, eff. 7-1-98, add matter in italic and deleted /1/"his" and
   /2/"he".

                                      D-3
<PAGE>

   (i) The Court shall direct the payment of the fair value of the shares,
together with interest, if any, by the surviving or resulting corporation to
the stockholders entitled thereto. Interest may be simple or compound, as the
Court may direct. Payment shall be so made to each such stockholder, in the
case of holders of uncertificated stock forthwith, and the case of holders of
shares represented by certificates upon the surrender to the corporation of the
certificates representing such stock. The Court's decree may be enforced as
other decrees in the Court of Chancery may be enforced, whether such surviving
or resulting corporation be a corporation of this State or of any state.

   (j) The costs of the proceeding may be determined by the Court and taxed
upon the parties as the Court deems equitable in the circumstances. Upon
application of a stockholder, the Court may order all or a portion of the
expenses incurred by any stockholder in connection with the appraisal
proceeding, including, without limitation, reasonable attorney's fees and the
fees and expenses of experts, to be charged pro rata against the value of all
the shares entitled to an appraisal.

   (k) From and after the effective date of the merger or consolidation, no
stockholder who has demanded /1/appraisal rights as provided in subsection (d)
of this section shall be entitled to vote such stock for any purpose or to
receive payment of dividends or other distributions on the stock (except
dividends or other distributions payable to stockholders of record at a date
which is prior to the effective date of the merger or consolidation); provided,
however, that if no petition for an appraisal shall be filed within the time
provided in subsection (e) of this section, or if such stockholder shall
deliver to the surviving or resulting corporation a written withdrawal of /1/
such stockholder's demand for an appraisal and an acceptance of the merger or
consolidation, either within 60 days after the effective date of the merger or
consolidation as provided in subsection (e) of this section or thereafter with
the written approval of the corporation, then the right of such stockholder to
an appraisal shall cease. Notwithstanding the foregoing, no appraisal
proceeding in the Court of Chancery shall be dismissed as to any stockholder
without the approval of the Court, and such approval may be conditioned upon
such terms as the Court deems just.

   (l) The shares of the surviving or resulting corporation to which the shares
of such objecting stockholders would have been converted had they assented to
the merger or consolidation shall have the status of authorized and unissued
shares of the surviving or resulting corporation. (Last amended by Ch. 339, L.
"98, eff. 7-1-98)

- --------
/1/Ch. 339, L. "98, eff. 7-1-98, add matter in italic and deleted /1/"his" and
   /2/"he".

                                      D-4
<PAGE>

                                    PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS

Item 20. Indemnification of Officers and Directors

   Section 145 of the Delaware General Corporation Law authorizes a court to
award, or a corporation's Board of Directors to grant, indemnification to
directors and officers in terms sufficiently broad to permit such
indemnification under certain circumstances for liabilities (including
reimbursement for expenses incurred) arising under the Securities Act. The
Registrant's bylaws provide for the mandatory indemnification of its directors,
officers, employees and other agents to the maximum extent permitted by
Delaware law, and the Registrant has entered into agreement with its officers,
directors and certain key employees implementing such indemnification.

Item 21. Exhibits and Financial Statement Schedules

   (a) Exhibits

   The following exhibits are filed herewith or incorporated herein by
reference.

<TABLE>
<CAPTION>
 Exhibit
 Number                                Description
 -------                               -----------
 <C>     <S>
  2.1    Agreement and Plan of Reorganization dated September 21, 1999 by and
         among Chemdex Corporation, Popcorn Acquisitions Corp. and
         Promedix.com, Inc. (included as Annex A to the Joint Proxy/Statement
         included as part of this Registration Statement)

  2.2    Form of Certificate of Merger between Popcorn Acquisitions Corp. and
         Promedix.com, Inc.

  2.3    Escrow Agreement (included as Annex B to the Joint Proxy/Statement
         included as part of this Registration Statement)

  3.1    Amended and Restated Certificate of Incorporation of Chemdex (1)

  3.2    Amended and Restated Bylaws of Chemdex (1)

  4.1    Specimen of Chemdex Common Stock Certificate (1)

  4.2    Third Amended and Restated Investors' Rights Agreement dated March 24,
         1999 (1)

  4.3    Amendment dated May 12, 1999 to Third Amended and Restated Investors'
         Rights Agreement (1)
  5.1*   Opinion of Venture Law Group, A Professional Corporation, as to the
         legality of the Registrant's common stock being registered hereby

  8.1*   Form of tax opinion of Venture Law Group, A Professional Corporation

  8.2*   Form of tax opinion of Orrick, Herrington & Sutcliffe LLP

 10.1    Form of Indemnification Agreement between Chemdex and each of its
         officers and directors (1)

 10.2    Form of Change of Control Agreement between Chemdex, each of its
         officers and certain employees (1)

 10.3    Change of Control Agreement between Chemdex and Robert A. Swanson (1)

 10.4    Change of Control Agreement between Chemdex and Charles R. Burke (1)

 10.5    1998 Stock Plan, as amended, and form of option agreement

 10.6    1999 Employee Stock Purchase Plan and form of subscription agreement

 10.7    1999 Directors' Stock Plan (1)

</TABLE>

                                      II-1
<PAGE>

<TABLE>
<CAPTION>
 Exhibit
 Number                               Description
 -------                              -----------
 <C>     <S>
 10.8    Standard Office Lease dated June 11, 1998 between Chemdex and Fabian
         Partners II, a California General Partnership, as amended (1)

 10.9    Master Lease Agreement dated January 20, 1999, as amended, between
         Chemdex and Comdisco, Inc. (1)

 10.10   Starter Kit Loan and Security Agreement dated February 18, 1998
         between Chemdex and Imperial Bank (1)

 10.11   Warrant Agreement to Purchase Shares of Series B Preferred Stock of
         Chemdex dated January 20, 1999 between Chemdex and Comdisco, Inc. (1)

 10.12   Warrant to Purchase Shares of Common Stock of Chemdex dated March 24,
         1999 between Chemdex and Galen Partners III, L.P. (1)

 10.13   Warrant to Purchase Shares of Common Stock of Chemdex dated March 24,
         1999 between Chemdex and Galen Partners International III, L.P. (1)

 10.14   Warrant to Purchase Shares of Common Stock of Chemdex dated March 24,
         1999 between Chemdex and Galen Employee Fund III, L.P. (1)

 10.15   Electronic Commerce Agreement dated January 5, 1998 between Chemdex
         and Genentech, Inc. (1)

 10.16   Standstill Agreement dated April 23, 1999 between Chemdex and VWR
         Scientific Products Corporation (1)

 10.17   Strategic Relationship Agreement dated April 30, 1999 between Chemdex
         and VWR Scientific Products Corporation (1)

 10.18   Joint Marketing Agreement dated May 11, 1999 between Chemdex and
         Biotechnology Industry Organization (1)

 10.19   Payment Plan Agreement dated February 22, 1999 and related agreements
         between Chemdex and Oracle Credit Corporation (1)

 10.20   Warrant Purchase Agreement dated July 27, 1999 between Chemdex and
         Alza Corporation (2)

 10.21   Office Lease dated August 13, 1999 between Chemdex and Alza
         Corporation for space located at 1000 Joaquin Road, Mountain View,
         California.

 10.22   Office Lease dated August 13, 1999 between Chemdex and Alza
         Corporation for space located at 1500 and 15550 Plymouth Street,
         Mountain View, California.

 10.23   Voting Agreement dated September 21, 1999 between Chemdex and certain
         stockholders of Promedix.com, Inc.

 10.24   Employment Agreement dated September 21, 1999 between Chemdex and
         William Klintworth

 10.25   Change of Control Agreement dated September 21, 1999 between Chemdex
         and William Klintworth

 10.26   Affiliates Agreement dated September 21, 1999 between Chemdex and
         certain stockholders of Promedix.com, Inc.

 10.27   Secured Promissory Note and Agreement dated September 21, 1999 from
         Promedix.com, Inc. to Chemdex and related Security agreement.

 10.28   Noncompetition Agreement dated September 21, 1999 between Chemdex and
         William Klintworth

 21.1    Subsidiaries of Chemdex
</TABLE>

                                      II-2
<PAGE>

<TABLE>
<CAPTION>
 Exhibit
 Number                                Description
 -------                               -----------
 <C>     <S>
 23.1*   Consent of Venture Law Group, A Professional Corporation, with respect
         to the legality of securities being registered (contained in Exhibit
         5.1)

 23.2*   Consent of Venture Law Group, A Professional Corporation, with respect
         to certain tax matters (contained in Exhibit 8.1)

 23.3*   Consent of Orrick, Herrington & Sutcliffe, with respect to certain tax
         matters (contained in Exhibit 8.2)

 23.4    Consent of Ernst & Young, Independent Auditors, with respect to
         financial statements of Chemdex

 23.5    Consent of Ernst & Young, Independent Auditors, with respect to the
         financial statements of Promedix

 23.6    Consent of Jones, Jensen & Company, Independent Auditors, with respect
         to financial statements of Pro Med Co.

 23.7    Consent of Morgan Stanley & Co. Incorporated

 24.1    Power of Attorney (included on page II-5)

 99.1*   Form of Proxy Card for Special Meeting of Chemdex Stockholders

 99.2*   Form of Proxy Card for Special Meeting of Promedix Stockholders
</TABLE>
- --------
* To be filed by amendment

(1) Incorporated by reference to the corresponding Exhibit previously filed as
    an Exhibit to Registrant's Registration Statement on Form S-1 (File No.
    333-78505) filed with the Commission on May 14, 1999, as amended, which
    Registration Statement was declared effective July 26, 1999.
(2) Incorporated by reference to the corresponding Exhibit previously filed as
    an Exhibit to Registrant's Form 10-Q filed with the Commission on August
    16, 1999.

   (b) Financial Statement Schedules

<TABLE>
<CAPTION>
         Schedule
         Number                     Description
         --------                   -----------
         <C>      <S>
           2.1    Chemdex Valuation and Qualifying Accounts

           2.2    Promedix Valuation and Qualifying Accounts

           2.3    Pro Med Co. Valuation and Qualifying Accounts

</TABLE>


Item 22. Undertakings

   A. The undersigned Registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Securities Exchange Act of 1934 (and, where applicable, each filing of an
employee benefit plan's annual report pursuant to Section 15(d) of the
Securities Exchange Act of 1934) that is incorporated by reference in this
registration statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

   B. The undersigned Registrant hereby undertakes as follows: that prior to
any public reoffering of the securities registered hereunder through use of a
prospectus which is a part of this registration statement, by any person or
party who is deemed to be an underwriter within the meaning of Rule 145(c), the
issuer undertakes that such reoffering prospectus will contain the information
called for by the applicable registration form with

                                      II-3
<PAGE>

respect to reofferings by persons who may be deemed underwriters, in addition
to the information called for by the other items of the applicable form.

   C. The Registrant undertakes that every prospectus: (i) that is filed
pursuant to paragraph (B) immediately proceeding, or (ii) that purports to meet
the requirements of Section 10(a)(3) of the Act and is used in connection with
an offering of securities subject to Rule 415, will be filed as a part of an
amendment to the registration statement and will not be used until such
amendment is effective, and that, for purposes of determining any liability
under the Securities Act of 1933, as amended, each such post-effective
amendment shall be deemed to be a new registration statement relating to the
securities offered therein, and the offering of such securities at that time
shall be deemed to be the initial bona fide offering thereof.

   D. Insofar as indemnification for liabilities arising under the Securities
Act of 1933 may be permitted to directors, officers and controlling persons of
the Registrant pursuant to the foregoing provisions, or otherwise, the
Registrant has been advised that in the opinion of the Securities and Exchange
Commission such indemnification is against public policy as expressed in the
Act and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
Registrant of expenses incurred or paid by a director, officer, or controlling
person of the Registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the Act and
will be governed by the final adjudication of such issue.

   E. The undersigned Registrant hereby undertakes to respond to requests for
information that is incorporated by reference into the prospectus pursuant to
Item 4, 10(b), 11, or 13 of this form, within one business day of receipt of
such request, and to send the incorporated documents by first class mail or
other equally prompt means. This includes information contained in documents
filed subsequent to the effective date of the registration statement through
the date of responding to the request.

   F. The undersigned Registrant hereby undertakes to supply by means of a
post-effective amendment all information concerning a transaction, and the
company being acquired involved therein, that was not the subject of and
included in the registration statement when it became effective.

                                      II-4
<PAGE>

                                   SIGNATURES

   Pursuant to the requirements of the Securities Act of 1933, the registrant
has duly caused this registration statement to be signed on its behalf by the
undersigned, thereunto duly authorized, in the City of Palo Alto, State of
California, on November 10, 1999.

                                          Chemdex Corporation

                                                    /s/ David P. Perry
                                          By: _________________________________
                                                     David P. Perry
                                              President and Chief Executive
                                                         Officer

   KNOW ALL MEN BY THESE PRESENTS, that each individual whose signature appears
below constitutes and appoints David P. Perry and James G. Stewart each of
them, his true and lawful attorneys-in-fact and agents with full power of
substitution and resubstitution, for him and in his name, place and stead, in
any and all capacities, to sign any and all amendments (including post-
effective amendments) to this registration statement and to file the same with
all exhibits thereto, and all documents in connection therewith, with the
Securities and Exchange Commission, granting unto said attorneys-in-fact and
agents, and each of them, full power and authority to do and perform each and
every act and thing requisite and necessary to be done, as fully to all intents
and purposes as he might or could do in person, hereby ratifying and confirming
all that said attorneys-in-fact and agents or any of them, or their or his
substitute or substitutes, may lawfully do or cause to be done by virtue
hereof. This power of attorney may be executed in counterparts.

   Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated:

<TABLE>
<CAPTION>
              Signature                          Title                   Date
              ---------                          -----                   ----

<S>                                    <C>                        <C>
        /s/ David P. Perry             President, Chief Executive  November 10, 1999
______________________________________  Officer and Director
            David P. Perry              (Principal Executive
                                        Officer)

       /s/ James G. Stewart            Chief Financial Officer     November 10, 1999
______________________________________  and Assistant Secretary
           James G. Stewart             (Principal Financial
                                        Officer)

       /s/ Charles R. Burke            Director                    November 10, 1999
______________________________________
           Charles R. Burke

        /s/ Brook H. Byers             Director                    November 10, 1999
______________________________________
            Brook H. Byers

    /s/ Jonathan D. Callaghan          Director                    November 10, 1999
______________________________________
        Jonathan D. Callaghan

      /s/ Jerrold B. Harris            Director                    November 10, 1999
______________________________________
          Jerrold B. Harris
</TABLE>


                                      II-5
<PAGE>

<TABLE>
<CAPTION>
              Signature                          Title                   Date
              ---------                          -----                   ----

<S>                                    <C>                        <C>
       /s/ S. Joshua Lewis             Director                    November 10, 1999
______________________________________
           S. Joshua Lewis

       /s/ John A. Pritzker            Director                    November 10, 1999
______________________________________
           John A. Pritzker

      /s/ Naomi O. Seligman            Director                    November 10, 1999
______________________________________
          Naomi O. Seligman

      /s/ Robert A. Swanson            Director                    November 10, 1999
______________________________________
          Robert A. Swanson

      /s/ L. John Wilkerson            Director                    November 10, 1999
______________________________________
          L. John Wilkerson
</TABLE>

                                      II-6
<PAGE>

                                                                     Item 21 (b)

                                                                    Schedule 2.1

                              CHEMDEX CORPORATION

                SCHEDULE 2.1--VALUATION AND QUALIFYING ACCOUNTS

                    December 31, 1997 and December 31, 1998

<TABLE>
<CAPTION>
                                                    Amounts
                                                   Charged to
                                          Balance   Revenue,  Write-offs Balance
                                         Beginning  Costs or     and     at End
              Description                 of Year   Expenses  Recoveries of Year
              -----------                --------- ---------- ---------- -------
<S>                                      <C>       <C>        <C>        <C>
1997
  Allowance for Doubtful Accounts.......   $--       $  --       $--     $  --
1998
  Allowance for Doubtful Accounts.......   $--       $2,000      $--     $2,000
</TABLE>
<PAGE>

                                                                     Item 21 (b)

                                                                    Schedule 2.2

                               PROMEDIX.COM, INC.

                SCHEDULE 2.2--VALUATION AND QUALIFYING ACCOUNTS

                    December 31, 1997 and December 31, 1998

<TABLE>
<CAPTION>
                                                    Amounts
                                                   Charged to
                                          Balance   Revenue,  Write-offs Balance
                                         Beginning  Costs or     and     at End
              Description                 of Year   Expenses  Recoveries of Year
              -----------                --------- ---------- ---------- -------
<S>                                      <C>       <C>        <C>        <C>
1997
  Allowance for Doubtful Accounts.......  $  --      $2,710    $   --    $2,710
1998
  Allowance for Doubtful Accounts.......  $2,710     $  --     $(2,710)  $  --
</TABLE>
<PAGE>

                                                                     Item 21 (b)

                                                                    Schedule 2.3

                               PRO MED CO., INC.

                SCHEDULE 2.3--VALUATION AND QUALIFYING ACCOUNTS

                    December 31, 19997 and December 31, 1998

<TABLE>
<CAPTION>
                                                    Amounts
                                                   Charged to
                                          Balance   Revenue,  Write-offs Balance
                                         Beginning  Costs or     and     at End
              Description                 of Year   Expenses  Recoveries of Year
              -----------                --------- ---------- ---------- -------
<S>                                      <C>       <C>        <C>        <C>
1997
  Allowance for Doubtful Accounts.......  $43,052    $ --       $ --     $43,052
1998
  Allowance for Doubtful Accounts.......  $43,052    $ --       $ --     $43,052
</TABLE>

                                      S-3

<PAGE>

                                    FORM OF                          EXHIBIT 2.2
                             CERTIFICATE OF MERGER


     The undersigned, the President of Promedix.com, Inc., a Delaware
corporation, hereby certifies in connection with the consolidation of
Promedix.com, Inc. and Popcorn Acquisition Corp. that:

     1.   The name and state of incorporation of each of the constituent
corporations of the consolidation is as follows:

          Name                                 State of Incorporation

          Popcorn Acquisition Corp.                   Delaware
          Promedix.com, Inc.                          Delaware

     2.   An agreement and plan of merger has been approved, adopted, certified,
executed and acknowledged by each of the constituent corporations in accordance
with the requirements of Section 251 of the General Corporation Law of the State
of Delaware.

     3.   The name of the resulting corporation of the consolidation is
Promedix.com, Inc..

     4.   The certificate of incorporation of Promedix.com, Inc., the resulting
corporation, shall be as set forth in the form attached hereto.

     5.   The executed agreement and plan of merger is on file at an office of
the resulting corporation. The address of the office of the resulting
corporation at which the agreement of consolidation is filed is Chemdex
Corporation, 1500 Plymouth Street, Mountain View, CA.

     6.   A copy of the agreement and plan of merger will be furnished by the
resulting corporation, on request and without cost, to any stockholder of any
constituent corporation.

     Unless required by law, Promedix.com, Inc. has caused the Certificate to be
signed by ____________, its authorized officer, this _____ day of December 1999.

                              PROMEDIX.COM, INC.

                              By:____________________________________
                                  President

                                      -1-

<PAGE>
                                                                    EXHIBIT 10.5

                              CHEMDEX CORPORATION

                                1998 STOCK PLAN

     1.   Purposes of the Plan.  The purposes of this 1998 Stock Plan are to
          --------------------
attract and retain the best available personnel for positions of substantial
responsibility, to provide additional incentive to Employees and Consultants of
the Company and its Subsidiaries and to promote the success of the Company's
business. Options granted under the Plan may be Incentive Stock Options (as
defined under Section 422 of the Code) or Nonstatutory Stock Options, as
determined by the Administrator at the time of grant of an option and subject to
the applicable provisions of Section 422 of the Code, as amended, and the
regulations promulgated thereunder. Stock purchase rights may also be granted
under the Plan.

     2.   Definitions. As used herein, the following definitions shall apply:
          -----------

          (a) "Administrator" means the Board or any of its Committees appointed
               -------------
          pursuant to Section 4 of the Plan.

          (b) "Applicable Laws" means the legal requirements relating to the
               ---------------
administration of stock option and restricted stock purchase plans under
applicable U.S. state corporate laws, U.S. federal and applicable state
securities laws, the Code, any stock exchange rules or regulations and the
applicable laws of any other country or jurisdiction where Options or Stock
Purchase Rights are granted under the Plan, as such laws, rules, regulations and
requirements shall be in place from time to time.

          (c) "Board" means the Board of Directors of the Company.
               -----

          (d) "Code" means the Internal Revenue Code of 1986, as amended.
               ----

          (e) "Committee" means the Committee appointed by the Board of
               ---------
Directors in accordance with Paragraph 4(a) of Section 4 of the Plan.

          (f) "Common Stock" means the Common Stock of the Company.
               ------------

          (g) "Company" means Chemdex Corporation, a Delaware corporation.
               -------

          (h) "Consultant" means any person, including an advisor, who is
               ----------
engaged by the Company or any Parent or Subsidiary to render services and is
compensated for such services, and any director of the Company whether
compensated for such services or not.

          (i) "Continuous Status as an Employee or Consultant" means the absence
               ----------------------------------------------
of any interruption or termination of service as an Employee or Consultant.
Continuous Status as an Employee or Consultant shall not be considered
interrupted in the case of:  (i) sick leave; (ii) military leave; (iii) any
other leave of absence approved by the Administrator, provided that such leave
is for a period of not more than 90 days, unless reemployment upon the
expiration of
<PAGE>

such leave is guaranteed by contract or statute, or unless provided otherwise
pursuant to Company policy adopted from time to time; or (iv) in the case of
transfers between locations of the Company or between the Company, its
Subsidiaries or their respective successors. For purposes of this Plan, a change
in status from an Employee to a Consultant or from a Consultant to an Employee
will not constitute an interruption of Continuous Status as an Employee or
Consultant.

          (j)  "Director" means a member of the Board.
                --------

          (k)  "Employee" means any person (including if appropriate, any Named
                --------
Executive, Officer or Director) employed by the Company or any Parent or
Subsidiary of the Company, with the status of employment determined based upon
such minimum number of hours or periods worked as shall be determined by the
Administrator in its discretion, subject to any requirements of the Code.  The
payment by the Company of a director's fee to a director shall not be sufficient
to constitute "employment" of such director by the Company.

          (l)  "Exchange Act" means the Securities Exchange Act of 1934, as
                ------------
amended.

          (m)  "Fair Market Value" means, as of any date, the fair market value
                -----------------
of Common Stock determined as follows:

               (i)   If the Common Stock is listed on any established stock
exchange or a national market system including without limitation the National
Market of the National Association of Securities Dealers, Inc. Automated
Quotation ("Nasdaq") System, its Fair Market Value shall be the closing sales
            ------
price for such stock (or the closing bid, if no sales were reported), as quoted
on such system or exchange, or the exchange with the greatest volume of trading
in Common Stock for the last market trading day prior to the time of
determination, as reported in The Wall Street Journal or such other source as
the Administrator deems reliable;

               (ii)  If the Common Stock is quoted on the Nasdaq System (but not
on the National Market thereof) or regularly quoted by a recognized securities
dealer but selling prices are not reported, its Fair Market Value shall be the
mean between the high bid and low asked prices for the Common Stock for the last
market trading day prior to the time of determination, as reported in The Wall
Street Journal or such other source as the Administrator deems reliable; or

               (iii) In the absence of an established market for the Common
Stock, the Fair Market Value thereof shall be determined in good faith by the
Administrator.

          (n)  "Incentive Stock Option" means an Option intended to qualify as
                ----------------------
an incentive stock option within the meaning of Section 422 of the Code, as
designated in the applicable written Option Agreement.

          (o)  "Listed Security" means any security of the Company that is
                ---------------
listed or approved for listing on a national securities exchange or designated
or approved for designation

                                      -2-
<PAGE>

as a national market system security on an interdealer quotation system by the
National Association of Securities Dealers, Inc.

          (p)   "Named Executive" means any individual who, on the last day of
                 ---------------
the Company's fiscal year, is the chief executive officer of the Company (or is
acting in such capacity) or among the four most highly compensated officers of
the Company (other than the chief executive officer). Such officer status shall
be determined pursuant to the executive compensation disclosure rules under the
Exchange Act.

          (q)   "Nonstatutory Stock Option" means an Option not intended to
                 -------------------------
qualify as an Incentive Stock Option, as designated in the applicable written
Option Agreement.

          (r)   "Officer" means a person who is an officer of the Company within
                 -------
the meaning of Section 16(a) of the Exchange Act and the rules and regulations
promulgated thereunder.

          (s)   "Option" means a stock option granted pursuant to the Plan.
                 ------

          (t)   "Option Agreement" means a written agreement between an Optionee
                 ----------------
and the Company reflecting the terms of an Option granted under the Plan and
includes any documents attached to such Option Agreement, including, but not
limited to, a notice of stock option grant and a form of exercise notice.

          (u)   "Optioned Stock" means the Common Stock subject to an Option or
                 --------------
a Stock Purchase Right.

          (v)   "Optionee" means an Employee or Consultant who receives an
                 --------
Option or a Stock Purchase Right.

          (w)   "Parent" means a "parent corporation," whether now or hereafter
                 ------
existing, as defined in Section 424(e) of the Code, or any successor provision.

          (x)   "Plan" means this 1998 Stock Plan.
                 ----

          (y)   "Reporting Person" means an Officer, Director, or greater than
                 ----------------
10% stockholder of the Company within the meaning of Rule 16a-2 under the
Exchange Act, who is required to file reports pursuant to Rule 16a-3 under the
Exchange Act.

          (z)   "Restricted Stock" means shares of Common Stock acquired
                 ----------------
pursuant to a grant of a Stock Purchase Right under Section 11 below.

          (aa)  "Restricted Stock Purchase Agreement" means a written agreement
                 -----------------------------------
between a holder of a Stock Purchase Right and the Company reflecting the terms
of a Stock Purchase Right granted under the Plan and includes any documents
attached to such agreement.

          (bb)  "Rule 16b-3" means Rule 16b-3 promulgated under the Exchange
                 ----------
Act, as the same may be amended from time to time, or any successor provision.

                                      -3-
<PAGE>

          (cc)  "Share" means a share of the Common Stock, as adjusted in
                 -----
accordance with Section 13 of the Plan.

          (dd)  "Stock Purchase Right" means the right to purchase Common Stock
                 --------------------
pursuant to Section 10 below.

          (ee)  "Subsidiary" means a "subsidiary corporation," whether now or
                 ----------
hereafter existing, as defined in Section 424(f) of the Code, or any successor
provision.

          (ff)  "Ten Percent Holder" means a person who owns stock representing
                 ------------------
more than ten percent (10%) of the voting power of all classes of stock of the
Company or any Parent or Subsidiary.

     3.  Stock Subject to the Plan. Subject to the provisions of Section 13 of
         -------------------------
the Plan, the maximum aggregate number of Shares that may be optioned and sold
under the Plan is 10,375,000 shares of Common Stock, plus an automatic annual
increase on the first day of each of the Company's fiscal years beginning in
2000 and ending in 2004 equal to the lesser of (i) 1,250,000 Shares, (ii) three
percent (3%) of the Shares outstanding on the last day of the immediately
preceding fiscal year, or (iii) such lesser number of shares as is determined by
the Board of Directors.  The Shares may be authorized, but unissued, or
reacquired Common Stock.

     If an Option should expire or become unexercisable for any reason without
having been exercised in full, the unpurchased Shares that were subject thereto
shall, unless the Plan shall have been terminated, become available for future
grant under the Plan. In addition, any Shares of Common Stock which are retained
by the Company upon exercise of an Option or Stock Purchase Right in order to
satisfy the exercise or purchase price for such Option or Stock Purchase Right
or any withholding taxes due with respect to such exercise shall be treated as
not issued and shall continue to be available under the Plan. Shares repurchased
by the Company pursuant to any repurchase right which the Company may have shall
not be available for future grant under the Plan.

     4.   Administration of the Plan.
          --------------------------

          (a)   General.  The Plan shall be administered by the Board or a
                -------
Committee, or a combination thereof, as determined by the Board.  The Plan may
be administered by different administrative bodies with respect to different
classes of Optionees and, if permitted by the Applicable Laws, the Board may
authorize one or more officers (who may (but need not) be Officers) to grant
Options or Stock Purchase Rights to Employees and Consultants.

          (b)   Administration With Respect to Reporting Persons. With respect
                ------------------------------------------------
to Options granted to Reporting Persons and Named Executives, the Plan may (but
need not) be administered so as to permit such Options to qualify for the
exemption set forth in Rule 16b-3 and to qualify as performance-based
compensation under Section 162(m) of the Code.

          (c)   Committee Composition. If a Committee has been appointed
                ---------------------
pursuant to this Section 4, such Committee shall continue to serve in its
designated capacity until otherwise

                                      -4-
<PAGE>

directed by the Board. From time to time the Board may increase the size of any
Committee and appoint additional members thereof, remove members (with or
without cause) and appoint new members in substitution therefor, fill vacancies
(however caused) and remove all members of a Committee and thereafter directly
administer the Plan, all to the extent permitted by the Applicable Laws and, in
the case of a Committee administering the Plan pursuant to Section 4(b) above,
to the extent permitted or required by Rule 16b-3 and Section 162(m) of the
Code.

          (d)  Powers of the Administrator. Subject to the provisions of the
               ---------------------------
Plan and in the case of a Committee, the specific duties delegated by the Board
to such Committee, and subject to the approval of any relevant authorities,
including the approval, if required, of any Stock Exchange, the Administrator
shall have the authority, in its discretion:

               (i)    to determine the Fair Market Value of the Common Stock, in
accordance with Section 2(m) of the Plan;

               (ii)   to select the Consultants and Employees to whom Options
and Stock Purchase Rights or any combination thereof may from time to time be
granted hereunder;

               (iii)  to determine whether and to what extent Options and Stock
Purchase Rights or any combination thereof are granted hereunder;

               (iv)   to determine the number of shares of Common Stock to be
covered by each such award granted hereunder;

               (v)    to approve forms of agreement for use under the Plan;

               (vi)   to determine the terms and conditions, not inconsistent
with the terms of the Plan, of any award granted hereunder, which terms and
conditions include but are not limited to the exercise or purchase price, the
time or times when Options or Stock Purchase Rights may be exercised (which may
be based on performance criteria), any vesting acceleration or waiver of
forfeiture restrictions, and any restriction or limitation regarding any Option,
Optioned Stock, Stock Purchase Right or Restricted Stock, based in each case on
such factors as the Administrator, in its sole discretion, shall determine;

               (vii)  to determine whether and under what circumstances an
Option may be settled in cash under Section 10(f) instead of Common Stock;

               (viii) to reduce the exercise price of any Option to the then
current Fair Market Value if the Fair Market Value of the Common Stock covered
by such Option shall have declined since the date the Option was granted;

               (ix)   to determine the terms and restrictions applicable to
Stock Purchase Rights and the Restricted Stock purchased by exercising such
Stock Purchase Rights; and

                                      -5-
<PAGE>

               (x)    to construe and interpret the terms of the Plan and awards
granted pursuant to the Plan; and

               (xi)   in order to fulfill the purposes of the Plan and without
amending the Plan, to modify grants of Options or Stock Purchase Rights to
participants who are foreign nationals or employed outside of the United States
in order to recognize differences in local law, tax policies or customs.

          (e)  Effect of Administrator's Decision. All decisions, determinations
               ----------------------------------
and interpretations of the Administrator shall be final and binding on all
holders of Options or Stock Purchase Rights.

     5.   Eligibility.
          -----------

          (a)  Recipients of Grants.  Nonstatutory Stock Options and Stock
               --------------------
Purchase Rights may be granted to Employees and Consultants. Incentive Stock
Options may be granted only to Employees. An Employee or Consultant who has been
granted an Option or Stock Purchase Right may, if he or she is otherwise
eligible, be granted additional Options or Stock Purchase Rights.

          (b)  Type of Option.  Each Option shall be designated in the Option
               --------------
Agreement as either an Incentive Stock Option or a Nonstatutory Stock Option.
However, notwithstanding such designations, to the extent that the aggregate
Fair Market Value of Shares with respect to which Options designated as
Incentive Stock Options are exercisable for the first time by any Optionee
during any calendar year (under all plans of the Company or any Parent or
Subsidiary) exceeds $100,000, such excess Options shall be treated as
Nonstatutory Stock Options. For purposes of this Section 5(b), Incentive Stock
Options shall be taken into account in the order in which they were granted, and
the Fair Market Value of the Shares subject to an Incentive Stock Option shall
be determined as of the date of the grant of such Option.

          (c)  The Plan shall not confer upon the holder of any Option or Stock
Purchase Right any right with respect to continuation of employment or
consulting relationship with the Company, nor shall it interfere in any way with
such holder's right or the Company's right to terminate his or her employment or
consulting relationship at any time, with or without cause.

     6.   Term of Plan.  The Plan shall become effective upon the earlier to
          ------------
occur of its adoption by the Board of Directors or its approval by the
stockholders of the Company as described in Section 19 of the Plan.  It shall
continue in effect for a term of ten years unless sooner terminated under
Section 16 of the Plan.

     7.   Term of Option.  The term of each Option shall be the term stated in
          --------------
the Option Agreement; provided, however, that the term shall be no more than ten
years from the date of grant thereof or such shorter term as may be provided in
the Option Agreement and provided further that, in the case of an Incentive
Stock Option granted to an Optionee who, at the time the Option is granted, is a
Ten Percent Holder, the term of the Option shall be five years from the date of
grant thereof or such shorter term as may be provided in the Option Agreement.

                                      -6-
<PAGE>

     8.   Limitation on Grants to Employees.  Subject to adjustment as provided
          ---------------------------------
in Section 14 below, the maximum number of Shares which may be subject to
Options and Stock Purchase Rights granted to any one Employee under this Plan
for any fiscal year of the Company shall be 10,000,000 Shares.

     9.   Option Exercise Price and Consideration.
          ---------------------------------------

          (a)  The per share exercise price for the Shares to be issued pursuant
to exercise of an Option shall be such price as is determined by the Board and
set forth in the applicable agreement, but shall be subject to the following:

               (i)  In the case of an Incentive Stock Option that is:

                    (A)  granted to an Employee who, at the time of the grant of
such Incentive Stock Option, is a Ten Percent Holder, the per Share exercise
price shall be no less than 110% of the Fair Market Value per Share on the date
of grant.

                    (B)  granted to any other Employee, the per Share exercise
price shall be no less than 100% of the Fair Market Value per Share on the date
of grant.

               (ii) In the case of a Nonstatutory Stock Option that is:

                    (A)  granted prior to the date, if any, on which the Common
Stock becomes a Listed Security to a person who, at the time of the grant of
such Option, is a Ten Percent Holder, the per Share exercise price shall be no
less than 110% of the Fair Market Value per Share on the date of the grant.

                    (B)  granted to a person who, at the time of the grant of
such Option, is a Named Executive of the Company, the per share Exercise Price
shall be no less than 100% of the Fair Market Value on the date of grant if such
Option is intended to qualify as performance-based compensation under Section
162(m) of the Code; or

                    (C)  granted prior to the date, if any, on which the Common
Stock becomes a Listed Security to any person other than a Named Executive or a
Ten Percent Holder, the per Share exercise price shall be no less than 85% of
the Fair Market Value per Share on the date of grant if required by the
Applicable Laws and, if not so required, shall be such price as is determined by
the Administrator.

          (b)  The consideration to be paid for the Shares to be issued upon
exercise of an Option, including the method of payment, shall be determined by
the Administrator (and, in the case of an Incentive Stock Option, shall be
determined at the time of grant) and may consist entirely of (1) cash, (2)
check, (3) promissory note (subject to the provisions of Section 153 of the
Delaware General Corporation Law), (4) other Shares that (x) in the case of
Shares acquired upon exercise of an Option, have been owned by the Optionee for
more than six months on the date of surrender or such other period as may be
required to avoid a charge to the Company's

                                      -7-
<PAGE>

earnings, and (y) have a Fair Market Value on the date of surrender equal to the
aggregate exercise price of the Shares as to which such Option shall be
exercised, (5) authorization for the Company to retain from the total number of
Shares as to which the Option is exercised that number of Shares having a Fair
Market Value on the date of exercise equal to the exercise price for the total
number of Shares as to which the Option is exercised, (6) delivery of a properly
executed exercise notice together with such other documentation as the
Administrator and the broker, if applicable, shall require to effect an exercise
of the Option and delivery to the Company of the sale or loan proceeds required
to pay the exercise price and any applicable income or employment taxes, (7)
delivery of an irrevocable subscription agreement for the Shares that
irrevocably obligates the option holder to take and pay for the Shares not more
than twelve months after the date of delivery of the subscription agreement, (8)
any combination of the foregoing methods of payment, or (9) such other
consideration and method of payment for the issuance of Shares to the extent
permitted under the Applicable Laws. In making its determination as to the type
of consideration to accept, the Administrator shall consider if acceptance of
such consideration may be reasonably expected to benefit the Company.

     10.  Exercise of Option.
          ------------------

          (a)  Procedure for Exercise; Rights as a Stockholder. Any Option
               -----------------------------------------------
granted hereunder shall be exercisable at such times and under such conditions
as determined by the Administrator and reflected in the Option Agreement, which
may include vesting requirements and/or performance criteria with respect to the
Company and/or the Optionee; provided, however, that if required by the
Applicable Laws, any Option granted prior to the date, if any, upon which the
Common Stock becomes a Listed Security shall become exercisable at the rate of
at least 20% per year over five years from the date the Option is granted. In
the event that any of the Shares issued upon exercise of an Option (which
exercise occurs prior to the date, if any, upon which the Common Stock becomes a
Listed Security) should be subject to a right of repurchase in the Company's
favor, such repurchase right shall, if required by the Applicable Laws, lapse at
the rate of at least 20% per year over five years from the date the Option is
granted. Notwithstanding the above, in the case of an Option granted to an
officer (including but not limited to Officers), Director or Consultant of the
Company or any Parent or Subsidiary of the Company, the Option may become fully
exercisable, and a repurchase right, if any, in favor of the Company shall
lapse, at any time or during any period established by the Administrator.

     An Option may not be exercised for a fraction of a Share.

     An Option shall be deemed to be exercised when written notice of such
exercise has been given to the Company in accordance with the terms of the
Option by the person entitled to exercise the Option and the Company has
received full payment for the Shares with respect to which the Option is
exercised. Full payment may, as authorized by the Board, consist of any
consideration and method of payment allowable under Section 8(b) of the Plan.
Until the issuance (as evidenced by the appropriate entry on the books of the
Company or of a duly authorized transfer agent of the Company) of the stock
certificate evidencing such Shares, no right to vote or receive dividends or any
other rights as a stockholder shall exist with respect to the Optioned Stock,
not withstanding the exercise of the Option. The Company shall issue (or

                                      -8-
<PAGE>

cause to be issued) such stock certificate promptly upon exercise of the Option.
No adjustment will be made for a dividend or other right for which the record
date is prior to the date the stock certificate is issued, except as provided in
Section 13 of the Plan.

     Exercise of an Option in any manner shall result in a decrease in the
number of Shares that thereafter may be available, both for purposes of the Plan
and for sale under the Option, by the number of Shares as to which the Option is
exercised.

          (b)  Termination of Employment or Consulting Relationship. In the
               ----------------------------------------------------
event of termination of an Optionee's Continuous Status as an Employee or
Consultant with the Company, such Optionee may, but only within three months (or
such other period of time not less than 30 days as is determined by the
Administrator, with such determination in the case of an Incentive Stock Option
being made at the time of grant of the Option and not exceeding three months)
after the date of such termination (but in no event later than the expiration
date of the term of such Option as set forth in the Option Agreement), exercise
his or her Option to the extent that the Optionee was entitled to exercise it at
the date of such termination. To the extent that the Optionee was not entitled
to exercise the Option at the date of such termination, or if the Optionee does
not exercise such Option to the extent so entitled within the time specified
herein, the Option shall terminate. No termination shall be deemed to occur and
this Section 10(b) shall not apply if (i) the Optionee is a Consultant who
becomes an Employee, or (ii) the Optionee is an Employee who becomes a
Consultant.

          (c)  Disability of Optionee.
               ----------------------

               (i)  Notwithstanding Section 10(b) above, in the event of
termination of an Optionee's Continuous Status as an Employee or Consultant as a
result of his or her total and permanent disability (within the meaning of
Section 22(e)(3) of the Code), such Optionee may, but only within twelve months
from the date of such termination (but in no event later than the expiration
date of the term of such Option as set forth in the Option Agreement), exercise
the Option to the extent otherwise entitled to exercise it at the date of such
termination. To the extent that the Optionee was not entitled to exercise the
Option at the date of termination, or if the Optionee does not exercise such
Option to the extent so entitled within the time specified herein, the Option
shall terminate.

               (ii) In the event of termination of an Optionee's Continuous
Status as an Employee or Consultant as a result of a disability which does not
fall within the meaning of total and permanent disability (as set forth in
Section 22(e)(3) of the Code), such Optionee may, but only within six months
from the date of such termination (but in no event later than the expiration
date of the term of such Option as set forth in the Option Agreement), exercise
the Option to the extent otherwise entitled to exercise it at the date of such
termination. However, to the extent that such Optionee fails to exercise an
Option which is an Incentive Stock Option ("ISO") (within the meaning of Section
                                            ---
422 of the Code) within three months of the date of such termination, the Option
will not qualify for ISO treatment under the Code. To the extent that the
Optionee was not entitled to exercise the Option at the date of termination, or
if the Optionee

                                      -9-
<PAGE>

does not exercise such Option to the extent so entitled within six months from
the date of termination, the Option shall terminate.

          (d)  Death of Optionee.  In the event of the death of an Optionee
               -----------------
during the period of Continuous Status as an Employee or Consultant since the
date of grant of the Option, or within 30 days following termination of the
Optionee's Continuous Status as an Employee or Consultant, the Option may be
exercised, at any time within six months following the date of death (but in no
event later than the expiration date of the term of such Option as set forth in
the Option Agreement), by such Optionee's estate or by a person who acquired the
right to exercise the Option by bequest or inheritance, but only to the extent
of the right to exercise that had accrued at the date of death or, if earlier,
the date of termination of the Optionee's Continuous Status as an Employee or
Consultant. To the extent that the Optionee was not entitled to exercise the
Option at the date of death or termination, as the case may be, or if the
Optionee does not exercise such Option to the extent so entitled within the time
specified herein, the Option shall terminate.

          (e)  Extension of Exercise Period. The Administrator shall have full
               ----------------------------
power and authority to extend the period of time for which an Option is to
remain exercisable following termination of an Optionee's Continuous Status as
an Employee or Consultant from the periods set forth in Sections 10(b), 10(c)
and 10(d) above or in the Option Agreement to such greater time as the Board
shall deem appropriate, provided that in no event shall such Option be
exercisable later than the date of expiration of the term of such Option as set
forth in the Option Agreement.

          (f)  Rule 16b-3.  Options granted to Reporting Persons shall comply
               ----------
with Rule 16b-3 and shall contain such additional conditions or restrictions as
may be required thereunder to qualify for the maximum exemption for Plan
transactions.

     11.  Stock Purchase Rights.
          ---------------------

          (a)  Rights to Purchase. Stock Purchase Rights may be issued either
               ------------------
alone, in addition to, or in tandem with other awards granted under the Plan
and/or cash awards made outside of the Plan. After the Administrator determines
that it will offer Stock Purchase Rights under the Plan, it shall advise the
offeree in writing of the terms, conditions and restrictions related to the
offer, including the number of Shares that such person shall be entitled to
purchase, the price to be paid, and the time within which such person must
accept such offer, which shall in no event exceed 30 days from the date upon
which the Administrator made the determination to grant the Stock Purchase
Right. In the case of a Stock Purchase Right granted prior to the date, if any,
on which the Common Stock becomes a Listed Security and if required by the
Applicable Laws at such time, the purchase price of Shares subject to such Stock
Purchase Rights shall not be less than 85% of the Fair Market Value of the
Shares as of the date of the offer, or, in the case of a Ten Percent Holder, the
price shall not be less than 100% of the Fair Market Value of the Shares as of
the date of the offer. If the Applicable Laws do not impose the requirements set
forth in the preceding sentence and with respect to any Stock Purchase Rights
granted after the date, if any, on which the Common Stock becomes a Listed
Security, the purchase price of

                                      -10-
<PAGE>

Shares subject to Stock Purchase Rights shall be as determined by the
Administrator. The offer shall be accepted by execution of a Restricted Stock
Purchase Agreement in the form determined by the Administrator.

          (b)  Repurchase Option. Unless the Administrator determines otherwise,
               -----------------
the Restricted Stock Purchase Agreement shall grant the Company a repurchase
option exercisable upon the voluntary or involuntary termination of the
purchaser's employment with the Company for any reason (including death or
disability). The purchase price for Shares repurchased pursuant to the
Restricted Stock Purchase Agreement shall be the original purchase price paid by
the purchaser and may be paid by cancellation of any indebtedness of the
purchaser to the Company. The repurchase option shall lapse at such rate as the
Administrator may determine; provided, however, that with respect to a Stock
Purchase Right granted prior to the date, if any, on which the Common Stock
becomes a Listed Security to a purchaser who is not an officer (including an
Officer), Director or Consultant of the Company or of any Parent or Subsidiary
of the Company, it shall lapse at a minimum rate of 20% per year if required by
the Applicable Laws.

          (c)  Other Provisions. The Restricted Stock Purchase Agreement shall
               ----------------
contain such other terms, provisions and conditions not inconsistent with the
Plan as may be determined by the Administrator in its sole discretion.  In
addition, the provisions of Restricted Stock Purchase Agreements need not be the
same with respect to each purchaser.

          (d)  Rights as a Stockholder. Once the Stock Purchase Right is
               -----------------------
exercised, the purchaser shall have the rights equivalent to those of a
stockholder, and shall be a stockholder when his or her purchase is entered upon
the records of the duly authorized transfer agent of the Company. No adjustment
will be made for a dividend or other right for which the record date is prior to
the date the Stock Purchase Right is exercised, except as provided in Section 12
of the Plan.

     12.  Taxes.
          -----

          (a)  As a condition of the exercise of an Option or Stock Purchase
Right granted under the Plan, the Participant (or in the case of the
Participant's death, the person exercising the Option or Stock Purchase Right)
shall make such arrangements as the Administrator may require for the
satisfaction of any applicable federal, state, local or foreign withholding tax
obligations that may arise in connection with the exercise of Option or Stock
Purchase Right and the issuance of Shares. The Company shall not be required to
issue any Shares under the Plan until such obligations are satisfied.

          (b)  In the case of an Employee and in the absence of any other
arrangement, the Employee shall be deemed to have directed the Company to
withhold or collect from his or her compensation an amount sufficient to satisfy
such tax obligations from the next payroll payment otherwise payable after the
date of an exercise of the Option or Stock Purchase Right.

          (c) This Section 12(c) shall apply only after the date, if any, upon
which the Common Stock becomes a Listed Security.  In the case of Participant
other than an Employee (or

                                      -11-
<PAGE>

in the case of an Employee where the next payroll payment is not sufficient to
satisfy such tax obligations, with respect to any remaining tax obligations), in
the absence of any other arrangement and to the extent permitted under the
Applicable Laws, the Participant shall be deemed to have elected to have the
Company withhold from the Shares to be issued upon exercise of the Option or
Stock Purchase Right that number of Shares having a Fair Market Value determined
as of the applicable Tax Date (as defined below) equal to the amount required to
be withheld. For purposes of this Section 12, the Fair Market Value of the
Shares to be withheld shall be determined on the date that the amount of tax to
be withheld is to be determined under the Applicable Laws (the "Tax Date").
                                                                --------

          (d)  If permitted by the Administrator, in its discretion, a
Participant may satisfy his or her tax withholding obligations upon exercise of
an Option or Stock Purchase Right by surrendering to the Company Shares that (i)
in the case of Shares previously acquired from the Company, have been owned by
the Participant for more than six (6) months on the date of surrender, and (ii)
have a Fair Market Value determined as of the applicable Tax Date equal to the
amount required to be withheld.

          (e)  Any election or deemed election by a Participant to have Shares
withheld to satisfy tax withholding obligations under Section 12(c) or (d) above
shall be irrevocable as to the particular Shares as to which the election is
made and shall be subject to the consent or disapproval of the Administrator.
Any election by a Participant under Section 12(d) above must be made on or prior
to the applicable Tax Date.

          (f)  In the event an election to have Shares withheld is made by a
Participant and the Tax Date is deferred under Section 83 of the Code because no
election is filed under Section 83(b) of the Code, the Participant shall receive
the full number of Shares with respect to which the Option or Stock Purchase
Right is exercised but such Participant shall be unconditionally obligated to
tender back to the Company the proper number of Shares on the applicable Tax
Date.

     13.  Adjustments Upon Changes in Capitalization, Merger or Certain Other
          -------------------------------------------------------------------
Transactions.
- ------------

          (a)  Changes in Capitalization.  Subject to any required action by the
               -------------------------
stockholders of the Company, the number of shares of Common Stock covered by
each outstanding Option or Stock Purchase Right, and the number of shares of
Common Stock that have been authorized for issuance under the Plan but as to
which no Options or Stock Purchase Rights have yet been granted or that have
been returned to the Plan upon cancellation or expiration of an Option or Stock
Purchase Right, the numbers of Shares set forth described in Sections 3(a)(i)
and 8 above, as well as the price per share of Common Stock covered by each such
outstanding Option or Stock Purchase Right, shall be proportionately adjusted
for any increase or decrease in the number of issued shares of Common Stock
resulting from a stock split, reverse stock split, stock dividend, combination,
recapitalization or reclassification of the Common Stock, or any other increase
or decrease in the number of issued shares of Common Stock effected without
receipt of consideration by the Company; provided, however, that

                                      -12-
<PAGE>

conversion of any convertible securities of the Company shall not be deemed to
have been "effected without receipt of consideration." Such adjustment shall be
made by the Board, whose determination in that respect shall be final, binding
and conclusive. Except as expressly provided herein, no issuance by the Company
of shares of stock of any class, or securities convertible into shares of stock
of any class, shall affect, and no adjustment by reason thereof shall be made
with respect to, the number or price of shares of Common Stock subject to an
Option or Stock Purchase Right.

          (b)  Dissolution or Liquidation.  In the event of the proposed
               --------------------------
dissolution or liquidation of the Company, the Board shall notify the Optionee
at least 15 days prior to such proposed action. To the extent it has not been
previously exercised, the Option or Stock Purchase Right will terminate
immediately prior to the consummation of such proposed action.

          (c)  Merger or Sale of Assets. In the event of a proposed sale of all
               ------------------------
or substantially all of the Company's assets or a merger of the Company with or
into another corporation where the successor corporation issues its securities
to the Company's stockholders, each outstanding Option or Stock Purchase Right
shall be assumed or an equivalent option or right shall be substituted by such
successor corporation or a parent or subsidiary of such successor corporation,
unless the successor corporation does not agree to assume the Option or Stock
Purchase Right or to substitute an equivalent option or right, in which case
such Option or Stock Purchase Right shall terminate upon the consummation of the
merger or sale of assets. For purposes of this Section 13(c), an Option or a
Stock Purchase Right shall be considered assumed, without limitation, if, at the
time of issuance of the stock or other consideration upon such merger or sale of
assets, each holder of an Option or a Stock Purchase Right would be entitled to
receive upon exercise of the Option or Stock Purchase Right the same number and
kind of shares of stock or the same amount of property, cash or securities as
such holder would have been entitled to receive upon the occurrence of such
transaction if the holder had been, immediately prior to such transaction, the
holder of the number of Shares of Common Stock covered by the Option or the
Stock Purchase Right at such time (after giving effect to any adjustments in the
number of Shares covered by the Option or Stock Purchase Right as provided for
in this Section 13).

          (d)  Certain Distributions. In the event of any distribution to the
               ---------------------
Company's stockholders of securities of any other entity or other assets (other
than dividends payable in cash or stock of the Company) without receipt of
consideration by the Company, the Administrator may, in its discretion,
appropriately adjust the price per share of Common Stock covered by each
outstanding Option or Stock Purchase Right to reflect the effect of such
distribution.

     14.  Non-Transferability of Options and Stock Purchase Rights.  Options and
          --------------------------------------------------------
Stock Purchase Rights may not be sold, pledged, assigned, hypothecated,
transferred, or disposed of in any manner other than by will or by the laws of
descent or distribution, provided that, after the date, if any, upon which the
Common Stock becomes a Listed Security, the Administrator may in its discretion
grant transferable Nonstatutory Stock Options pursuant to Option Agreements
specifying (i) the manner in which such Nonstatutory Stock Options are
transferable and (ii) that any such transfer shall be subject to the Applicable
Laws. The designation of a

                                      -13-
<PAGE>

beneficiary by an Optionee will not constitute a transfer. An Option or Stock
Purchase Right may be exercised, during the lifetime of the holder of Option or
Stock Purchase Right, only by such holder or a transferee permitted by this
Section 14.

     15.  Time of Granting Options and Stock Purchase Rights. The date of grant
          --------------------------------------------------
of an Option or Stock Purchase Right shall, for all purposes, be the date on
which the Administrator makes the determination granting such Option or Stock
Purchase Right, or such other date as is determined by the Board; provided,
however, that in the case of any Incentive Stock Option, the grant date shall be
the later of the date on which the Administrator makes the determination
granting such Incentive Stock Option or the date of commencement of the
Optionee's employment relationship with the Company. Notice of the determination
shall be given to each Employee or Consultant to whom an Option or Stock
Purchase Right is so granted within a reasonable time after the date of such
grant.

     16.  Amendment and Termination of the Plan.
          -------------------------------------

          (a)  Authority to Amend or Terminate. The Board may at any time amend,
               -------------------------------
alter, suspend or discontinue the Plan, but no amendment, alteration, suspension
or discontinuation (other than an adjustment under pursuant to Section 13 above)
shall be made that would impair the rights of any Optionee under any grant
theretofore made, without his or her consent. In addition, to the extent
necessary and desirable to comply with the Applicable Laws, the Company shall
obtain stockholder approval of any Plan amendment in such a manner and to such a
degree as required

          (b)  Effect of Amendment or Termination. No amendment or termination
               ----------------------------------
of the Plan shall adversely affect Options already granted, unless mutually
agreed otherwise between the Optionee and the Board, which agreement must be in
writing and signed by the Optionee and the Company.

     17.  Conditions Upon Issuance of Shares.  Shares shall not be issued
          ----------------------------------
pursuant to the exercise of an Option or Stock Purchase Right unless the
exercise of such Option or Stock Purchase Right and the issuance and delivery of
such Shares pursuant thereto shall comply with the Applicable Laws.

     As a condition to the exercise of an Option, the Company may require the
person exercising such Option to represent and warrant at the time of any such
exercise that the Shares are being purchased only for investment and without any
present intention to sell or distribute such Shares if, in the opinion of
counsel for the Company, such a representation is required by law.

     18.  Reservation of Shares.  The Company, during the term of this Plan,
          ---------------------
will at all times reserve and keep available such number of Shares as shall be
sufficient to satisfy the requirements of the Plan.  The inability of the
Company to obtain authority from any regulatory body having jurisdiction, which
authority is deemed by the Company's counsel to be necessary to the lawful
issuance and sale of any Shares hereunder, shall relieve the Company of any

                                      -14-
<PAGE>

liability in respect of the failure to issue or sell such Shares as to which
such requisite authority shall not have been obtained.

     19.  Agreements. Options and Stock Purchase Rights shall be evidenced by
          ----------
written Option Agreements and Restricted Stock Purchase Agreements,
respectively, in such form(s) as the Administrator shall approve from time to
time.

     20.  Stockholder Approval. If required by the Applicable Laws, continuance
          --------------------
of the Plan shall be subject to approval by the stockholders of the Company
within twelve months before or after the date the Plan is adopted. Such
stockholder approval shall be obtained in the manner and to the degree required
under the Applicable Laws.

     21.  Information and Documents to Optionees and Purchasers.  Prior to the
          -----------------------------------------------------
date, if any, upon which the Common Stock becomes a Listed Security and if
required by the Applicable Laws, the Company shall provide financial statements
at least annually to each Optionee and to each individual who acquired Shares
Pursuant to the Plan, during the period such Optionee or purchaser has one or
more Options or Stock Purchase Rights outstanding, and in the case of an
individual who acquired Shares pursuant to the Plan, during the period such
individual owns such Shares. The Company shall not be required to provide such
information if the issuance of Options or Stock Purchase Rights under the Plan
is limited to key employees whose duties in connection with the Company assure
their access to equivalent information. In addition, at the time of issuance of
any securities under the Plan, the Company shall provide to the Optionee or the
Purchaser a copy of the Plan and any agreement(s) pursuant to which securities
granted under the Plan are issued.

                                      -15-

<PAGE>
                                                                    EXHIBIT 10.6
                              CHEMDEX CORPORATION

                       1999 EMPLOYEE STOCK PURCHASE PLAN
                       ---------------------------------

     The following constitute the provisions of the 1999 Employee Stock Purchase
Plan of Chemdex Corporation:

     1.  Purpose.  The purpose of the Plan is to provide employees of the
         -------
Company and its Designated Subsidiaries with an opportunity to purchase Common
Stock of the Company.  It is the intention of the Company to have the Plan
qualify as an "Employee Stock Purchase Plan" under Section 423 of the Code.  The
provisions of the Plan shall, accordingly, be construed so as to extend and
limit participation in a manner consistent with the requirements of that section
of the Code.

     2.  Definitions.
         -----------

         (a) "Board" means the Board of Directors of the Company.
              -----

         (b) "Code" means the Internal Revenue Code of 1986, as amended.
              ----

         (c) "Common Stock" means the Common Stock of the Company.
              ------------

         (d) "Company" means Chemdex Corporation, a Delaware corporation.
              -------

         (e) "Compensation" means total cash compensation received by an
              ------------
Employee from the Company or a Designated Subsidiary.  By way of illustration,
but not limitation, Compensation includes regular compensation such as salary,
wages, overtime, shift differentials, bonuses, commissions and incentive
compensation, but excludes relocation, expense reimbursements, tuition or other
reimbursements and income realized as a result of participation in any stock
option, stock purchase, or similar plan of the Company or any Designated
Subsidiary.

         (f) "Continuous Status as an Employee" means the absence of any
              --------------------------------
interruption or termination of service as an Employee.  Continuous Status as an
Employee shall not be considered interrupted in the case of (i) sick leave; (ii)
military leave; (iii) any other leave of absence approved by the Administrator,
provided that such leave is for a period of not more than 90 days, unless
reemployment upon the expiration of such leave is guaranteed by contract or
statute, or unless provided otherwise pursuant to Company policy adopted from
time to time; or (iv) in the case of transfers between locations of the Company
or between the Company and its Designated Subsidiaries.

         (g) "Contributions" means all amounts credited to the account of a
              -------------
participant pursuant to the Plan.

         (h) "Corporate Transaction" means a sale of all or substantially all
              ---------------------
of the Company's assets, or a merger, consolidation or other capital
reorganization of the Company with or into another corporation, or any other
transaction or series of related transactions in
<PAGE>

which the Company's stockholders immediately prior thereto own less than 50% of
the voting stock of the Company (or its successor or parent) immediately
thereafter.

         (i) "Designated Subsidiaries" means the Subsidiaries that have been
              -----------------------
designated by the Board from time to time in its sole discretion as eligible to
participate in the Plan; provided however that the Board shall only have the
discretion to designate Subsidiaries if the issuance of options to such
Subsidiary's Employees pursuant to the Plan would not cause the Company to incur
adverse accounting charges.

         (j) "Employee" means any person, including an Officer, who is an
              --------
Employee for tax purposes and who is customarily employed for at least twenty
(20) hours per week and more than five (5) months in a calendar year by the
Company or one of its Designated Subsidiaries.

         (k) "Exchange Act" means the Securities Exchange Act of 1934, as
              ------------
amended.

         (l) "Offering Date" means the first business day of each Offering
              -------------
Period of the Plan.

         (m) "Offering Period" means a period of twenty-four (24) months
              ---------------
commencing on February 16 and August 16 of each year, except for the first
Offering Period as set forth in Section 4(a).

         (n) "Officer" means a person who is an officer of the Company within
              -------
the meaning of Section 16 of the Exchange Act and the rules and regulations
promulgated thereunder.

         (o) "Plan" means this Employee Stock Purchase Plan.
              ----

         (p) "Purchase Date" means the last day of each Purchase Period of the
              -------------
Plan.

         (q) "Purchase Period" means a period of six (6) months within an
              ---------------
Offering Period, except as set forth in Section 4(b).

         (r) "Purchase Price" means with respect to a Purchase Period an amount
              --------------
equal to 85% of the Fair Market Value (as defined in Section 7(b) below) of a
Share of Common Stock on the Offering Date or on the Purchase Date, whichever is
lower; provided, however, that in the event (i) of any increase in the number of
Shares available for issuance under the Plan as a result of a stockholder-
approved amendment to the Plan, and (ii) all or a portion of such additional
Shares are to be issued with respect to one or more Offering Periods that are
underway at the time of such increase ("Additional Shares"), and (iii) the Fair
                                        -----------------
Market Value of a Share of Common Stock on the date of such increase (the

"Approval Date Fair Market Value") is higher than the Fair Market Value on the
 -------------------------------
Offering Date for any such Offering Period, then in such instance the Purchase
Price with respect to Additional Shares shall be 85% of the Approval Date Fair
Market Value or the Fair Market Value of a Share of Common Stock on the Purchase
Date, whichever is lower.

                                      -2-
<PAGE>

         (s) "Share" means a share of Common Stock, as adjusted in accordance
               -----
with Section 19 of the Plan.

         (t) "Subsidiary" means a corporation, domestic or foreign, of which
               ----------
not less than 50% of the voting shares are held by the Company or a Subsidiary,
whether or not such corporation now exists or is hereafter organized or acquired
by the Company or a Subsidiary.

     3.  Eligibility.
         -----------

         (a) Any person who is an Employee as of the Offering Date of a given
Offering Period shall be eligible to participate in such Offering Period under
the Plan, subject to the requirements of Section 5(a) and the limitations
imposed by Section 423(b) of the Code; provided however that eligible Employees
may not participate in more than one Offering Period at a time.

         (b) Any provisions of the Plan to the contrary notwithstanding, no
Employee shall be granted an option under the Plan (i) if, immediately after the
grant, such Employee (or any other person whose stock would be attributed to
such Employee pursuant to Section 424(d) of the Code) would own capital stock of
the Company and/or hold outstanding options to purchase stock possessing five
percent (5%) or more of the total combined voting power or value of all classes
of stock of the Company or of any subsidiary of the Company, or (ii) if such
option would permit his or her rights to purchase stock under all employee stock
purchase plans (described in Section 423 of the Code) of the Company and its
Subsidiaries to accrue at a rate that exceeds Twenty-Five Thousand Dollars
($25,000) of the Fair Market Value (as defined in Section 7(b) below) of such
stock (determined at the time such option is granted) for each calendar year in
which such option is outstanding at any time.

     4.  Offering Periods and Purchase Periods.
         -------------------------------------

         (a) Offering Periods.  The Plan shall be generally implemented by a
             ----------------
series of Offering Periods of twenty-four (24) months' duration, with new
Offering Periods (other than the first Offering Period) commencing on or about
February 16 and  August 16 of each year (or at such other time or times as may
be determined by the Board of Directors).  The first Offering Period shall
commence on the beginning of the effective date of the Registration Statement on
Form S-1 for the initial public offering of the Company's Common Stock (the "IPO
                                                                             ---
Date") and continue until August 15, 2001.  The Plan shall continue until
- ----
terminated in accordance with Section 19 hereof.  The Board of Directors of the
Company shall have the power to change the duration and/or the frequency of
Offering Periods with respect to future offerings without stockholder approval
if such change is announced at least five (5) days prior to the scheduled
beginning of the first Offering Period to be affected.

         (b) Purchase Periods.  Each Offering Period shall generally consist of
             ----------------
four (4) consecutive purchase periods of six (6) months' duration.  The last day
of each Purchase Period shall be the "Purchase Date" for such Purchase Period.
                                      -------------
A Purchase Period commencing on February 16 shall end on the next August 15.  A
Purchase Period commencing on  August 16 shall end on the next February 15.  The
first Purchase Period of the first Offering Period shall

                                      -3-
<PAGE>

commence on the IPO Date and shall end on February 15, 2000. The Board of
Directors of the Company shall have the power to change the duration and/or
frequency of Purchase Periods with respect to future purchases without
stockholder approval if such change is announced at least five (5) days prior to
the scheduled beginning of the first Purchase Period to be affected.

     5.  Participation.
         -------------

         (a) An eligible Employee may become a participant in the Plan by
completing a subscription agreement on the form provided by the Company and
filing it with the Company's payroll office or the stock brokerage or other
financial services firm designated by the Company (the "Designated Broker")
prior to the applicable Offering Date, unless a later time for filing the
subscription agreement is set by the Board for all eligible Employees with
respect to a given Offering Period.  The subscription agreement shall set forth
the percentage of the participant's Compensation (subject to Section 6(a) below)
to be paid as Contributions pursuant to the Plan.

         (b) Payroll deductions shall commence on the first full payroll
following the Offering Date and shall end on the last payroll paid on or prior
to the last Purchase Period of the Offering Period to which the subscription
agreement is applicable, unless sooner terminated by the participant as provided
in Section 10.

     6.  Method of Payment of Contributions.
         ----------------------------------

         (a) A participant shall elect to have payroll deductions made on each
payday during the Offering Period in an amount not less than one percent (1%)
and not more than twenty percent (20%) (or such other percentage as the Board
may establish from time to time before an Offering Date) of such participant's
Compensation on each payday during the Offering Period.  All payroll deductions
made by a participant shall be credited to his or her account under the Plan.  A
participant may not make any additional payments into such account.

         (b) A participant may discontinue his or her participation in the Plan
as provided in Section 10, or may increase or decrease the rate of his or her
Contributions by completing and filing with the Company or its Designated Broker
a new subscription agreement authorizing a change in the payroll deduction rate.
The Board may, in its discretion, limit the number of rate changes during any
Offering Period.  The change in rate shall be effective with the first full
payroll following five (5) business days after the Company's receipt of the new
subscription agreement, unless the Company elects to process a given rate change
more quickly.  A participant's subscription agreement shall remain in effect for
successive Offering Periods unless terminated as provided in Section 10.

         (c) Notwithstanding the foregoing, to the extent necessary to comply
with Section 423(b)(8) of the Code and Section 3(b) herein, a participant's
payroll deductions may be decreased during any Offering Period scheduled to end
during the current calendar year to 0%.  Payroll deductions shall re-commence at
the rate provided in such participant's subscription agreement at the beginning
of the first Offering Period that is scheduled to end in the following calendar
year, unless terminated by the participant as provided in Section 10.

                                      -4-
<PAGE>

     7.  Grant of Option.
         ---------------

         (a) On the Offering Date of each Offering Period, each eligible
Employee participating in such Offering Period shall be granted an option to
purchase on each Purchase Date a number of Shares of the Company's Common Stock
determined by dividing such Employee's Contributions accumulated prior to such
Purchase Date and retained in the participant's account as of the Purchase Date
by the applicable Purchase Price; provided however that the maximum number of
Shares an Employee may purchase during each Purchase Period shall be 1,250
Shares (subject to any adjustment pursuant to Section 19 below), and provided
further that such purchase shall be subject to the limitations set forth in
Sections 3(b) and 13.

         (b) The fair market value of the Company's Common Stock on a given
date (the "Fair Market Value") shall be determined by the Board in its
           -----------------
discretion based on the closing sales price of the Common Stock for such date
(or, in the event that the Common Stock is not traded on such date, on the
immediately preceding trading date), as reported by the National Association of
Securities Dealers Automated Quotation (Nasdaq) National Market or, if such
price is not reported, the mean of the bid and asked prices per share of the
Common Stock as reported by Nasdaq or, in the event the Common Stock is listed
on a stock exchange, the Fair Market Value per share shall be the closing sales
price on such exchange on such date (or, in the event that the Common Stock is
not traded on such date, on the immediately preceding trading date), as reported
in The Wall Street Journal.  For purposes of the Offering Date under the first
   -----------------------
Offering Period under the Plan, the Fair Market Value of a share of the Common
Stock of the Company shall be the Price to Public as set forth in the final
prospectus filed with the Securities and Exchange Commission pursuant to Rule
424 under the Securities Act of 1933, as amended.

     8.  Exercise of Option.  Unless a participant withdraws from the Plan as
         ------------------
provided in Section 10, his or her option for the purchase of Shares will be
exercised automatically on each Purchase Date of an Offering Period, and the
maximum number of full Shares subject to the option will be purchased at the
applicable Purchase Price with the accumulated Contributions in his or her
account.  No fractional Shares shall be issued; any payroll deductions
accumulated in a participant's account that are not sufficient to purchase a
full Share shall be retained in the participant's account for the subsequent
Purchase Period or Offering Period, subject to earlier withdrawal by the
participant as provided in Section 10 below.  Any other amounts left over in a
participant's account after a Purchase Date shall be returned to the
participant.  During his or her lifetime, a participant's option to purchase
Shares hereunder is exercisable only by him or her.

     9.  Delivery.  As promptly as practicable after each Purchase Date of each
         --------
Offering Period, the number of Shares purchased by each participant upon
exercise of his or her option shall be deposited into an account established in
the participant's name with the Designated Broker.

     10.  Voluntary Withdrawal; Termination of Employment.
          -----------------------------------------------

          (a) A participant may withdraw all but not less than all the
Contributions credited to his or her account under the Plan at any time prior to
each Purchase Date by giving written notice to the Company or the Designated
Broker, as directed by the Company.  All of the

                                      -5-
<PAGE>

participant's Contributions credited to his or her account will be paid to him
or her promptly after receipt of his or her notice of withdrawal and his or her
option for the current period will be automatically terminated, and no further
Contributions for the purchase of Shares will be made during the Offering
Period.

          (b) Upon termination of the participant's Continuous Status as an
Employee prior to the Purchase Date of an Offering Period for any reason,
including retirement or death, the Contributions credited to his or her account
will be returned to him or her or, in the case of his or her death, to the
person or persons entitled thereto under Section 14, and his or her option will
be automatically terminated.

          (c) In the event an Employee fails to remain in Continuous Status as
an Employee of the Company for at least twenty (20) hours per week during the
Offering Period in which the employee is a participant, he or she will be deemed
to have elected to withdraw from the Plan and the Contributions credited to his
or her account will be returned to him or her and his or her option terminated.

          (d) A participant's withdrawal from an offering will not have any
effect upon his or her eligibility to participate in a succeeding offering or in
any similar plan that may hereafter be adopted by the Company.

     11.  Automatic Withdrawal.  If the Fair Market Value of the Shares on any
          --------------------
Purchase Date of an Offering Period is less than the Fair Market Value of the
Shares on the Offering Date for such Offering Period, then every participant
shall automatically (i) be withdrawn from such Offering Period at the close of
such Purchase Date and after the acquisition of Shares for such Purchase Period,
and (ii) be enrolled in the Offering Period commencing on the first business day
subsequent to such Purchase Period.  Participants shall automatically be
withdrawn as of August 15, 1999 from the Offering Period beginning on the IPO
Date and re-enrolled in the Offering Period beginning on August 16, 1999 if the
Fair Market Value of the Shares on the IPO Date is greater than the Fair Market
Value of the Shares on August 15, 1999, unless a participant notifies the
Administrator prior to August 15, 1999 that he or she does not wish to be
withdrawn and re-enrolled.

     12.  Interest.  No interest shall accrue on the Contributions of a
          --------
participant in the Plan.

     13.  Stock.
          -----

          (a) Subject to adjustment as provided in Section 19, the maximum
number of Shares which shall be made available for sale under the Plan shall be
1,050,000 Shares, plus an automatic annual increase on the first day of each of
the Company's fiscal years beginning in 2000, 2001, 2002, 2003 and 2004 equal to
the lesser of (i) 200,000 Shares, (ii) one-half of one  percent (.5%) of the
Shares outstanding on the last day of the immediately preceding fiscal year or
(iii) a lesser amount determined by the Board.  If the Board determines that, on
a given Purchase Date, the number of shares with respect to which options are to
be exercised may exceed (i) the number of shares of Common Stock that were
available for sale under the Plan on

                                      -6-
<PAGE>

the Offering Date of the applicable Offering Period, or (ii) the number of
shares available for sale under the Plan on such Purchase Date, the Board may in
its sole discretion provide (x) that the Company shall make a pro rata
allocation of the Shares of Common Stock available for purchase on such Offering
Date or Purchase Date, as applicable, in as uniform a manner as shall be
practicable and as it shall determine in its sole discretion to be equitable
among all participants exercising options to purchase Common Stock on such
Purchase Date, and continue all Offering Periods then in effect, or (y) that the
Company shall make a pro rata allocation of the shares available for purchase on
such Offering Date or Purchase Date, as applicable, in as uniform a manner as
shall be practicable and as it shall determine in its sole discretion to be
equitable among all participants exercising options to purchase Common Stock on
such Purchase Date, and terminate any or all Offering Periods then in effect
pursuant to Section 20 below. The Company may make pro rata allocation of the
Shares available on the Offering Date of any applicable Offering Period pursuant
to the preceding sentence, notwithstanding any authorization of additional
Shares for issuance under the Plan by the Company's stockholders subsequent to
such Offering Date.

          (b) The participant shall have no interest or voting right in Shares
covered by his or her option until such option has been exercised.

          (c) Shares to be delivered to a participant under the Plan will be
registered in the name of the participant or in the name of the participant and
his or her spouse.

     14.  Administration.  The Board, or a committee named by the Board, shall
          --------------
supervise and administer the Plan and shall have full power to adopt, amend and
rescind any rules deemed desirable and appropriate for the administration of the
Plan and not inconsistent with the Plan, to construe and interpret the Plan, and
to make all other determinations necessary or advisable for the administration
of the Plan.

     15.  Designation of Beneficiary.
          --------------------------

          (a) A participant may file a written designation of a beneficiary who
is to receive any Shares and cash, if any, from the participant's account under
the Plan in the event of such participant's death subsequent to the end of a
Purchase Period but prior to delivery to him or her of such Shares and cash.  In
addition, a participant may file a written designation of a beneficiary who is
to receive any cash from the participant's account under the Plan in the event
of such participant's death prior to the Purchase Date of an Offering Period.
If a participant is married and the designated beneficiary is not the spouse,
spousal consent shall be required for such designation to be effective.

          (b) Such designation of beneficiary may be changed by the participant
(and his or her spouse, if any) at any time by written notice.  In the event of
the death of a participant and in the absence of a beneficiary validly
designated under the Plan who is living at the time of such participant's death,
the Company shall deliver such Shares and/or cash to the executor or
administrator of the estate of the participant, or if no such executor or
administrator has been appointed (to the knowledge of the Company), the Company,
in its discretion, may deliver such Shares and/or cash to the spouse or to any
one or more dependents or relatives of the participant,

                                      -7-
<PAGE>

or if no spouse, dependent or relative is known to the Company, then to such
other person as the Company may designate.

     16.  Transferability.  Neither Contributions credited to a participant's
          ---------------
account nor any rights with regard to the exercise of an option or to receive
Shares under the Plan may be assigned, transferred, pledged or otherwise
disposed of in any way (other than by will, the laws of descent and
distribution, or as provided in Section 15) by the participant.  Any such
attempt at assignment, transfer, pledge or other disposition shall be without
effect, except that the Company may treat such act as an election to withdraw
funds in accordance with Section 10.

     17.  Use of Funds.  All Contributions received or held by the Company under
          ------------
the Plan may be used by the Company for any corporate purpose, and the Company
shall not be obligated to segregate such Contributions.

     18.  Reports.  Individual accounts will be maintained for each participant
          -------
in the Plan.  Statements of account will be given to participating Employees at
least annually, which statements will set forth the amounts of Contributions,
the per Share Purchase Price, the number of Shares purchased and the remaining
cash balance, if any.

     19.  Adjustments Upon Changes in Capitalization; Corporate Transactions.
          ------------------------------------------------------------------

          (a) Adjustment.  Subject to any required action by the stockholders of
              ----------
the Company, the number of Shares covered by each option under the Plan that has
not yet been exercised and the number of Shares that have been authorized for
issuance under the Plan but have not yet been placed under option (collectively,
the "Reserves"), as well as the maximum number of shares of Common Stock that
     --------
may be purchased by a participant in a Purchase Period, the number of shares of
Common Stock set forth in Section 13(a)(i) above, and the price per Share of
Common Stock covered by each option under the Plan that has not yet been
exercised, shall be proportionately adjusted for any increase or decrease in the
number of issued Shares resulting from a stock split, reverse stock split, stock
dividend, combination or reclassification of the Common Stock (including any
such change in the number of Shares of Common Stock effected in connection with
a change in domicile of the Company), or any other increase or decrease in the
number of Shares effected without receipt of consideration by the Company;
provided however that conversion of any convertible securities of the Company
shall not be deemed to have been "effected without receipt of consideration."
Such adjustment shall be made by the Board, whose determination in that respect
shall be final, binding and conclusive.  Except as expressly provided herein, no
issue by the Company of shares of stock of any class, or securities convertible
into shares of stock of any class, shall affect, and no adjustment by reason
thereof shall be made with respect to, the number or price of Shares subject to
an option.

          (b) Corporate Transactions.  In the event of a dissolution or
              ----------------------
liquidation of the Company, any Purchase Period and Offering Period then in
progress will terminate immediately prior to the consummation of such action,
unless otherwise provided by the Board. In the event of a Corporate Transaction,
each option outstanding under the Plan shall be assumed or an equivalent option
shall be substituted by the successor corporation or a parent or Subsidiary of
such successor corporation.  In the event that the successor corporation refuses
to assume or

                                      -8-
<PAGE>

substitute for outstanding options, each Purchase Period and Offering Period
then in progress shall be shortened and a new Purchase Date shall be set
(the "New Purchase Date"), as of which date any Purchase Period and Offering
      -----------------
Period then in progress will terminate. The New Purchase Date shall be on or
before the date of consummation of the transaction and the Board shall notify
each participant in writing, at least ten (10) days prior to the New Purchase
Date, that the Purchase Date for his or her option has been changed to the New
Purchase Date and that his or her option will be exercised automatically on the
New Purchase Date, unless prior to such date he or she has withdrawn from the
Offering Period as provided in Section 10. For purposes of this Section 19, an
option granted under the Plan shall be deemed to be assumed, without limitation,
if, at the time of issuance of the stock or other consideration upon a Corporate
Transaction, each holder of an option under the Plan would be entitled to
receive upon exercise of the option the same number and kind of shares of stock
or the same amount of property, cash or securities as such holder would have
been entitled to receive upon the occurrence of the transaction if the holder
had been, immediately prior to the transaction, the holder of the number of
Shares of Common Stock covered by the option at such time (after giving effect
to any adjustments in the number of Shares covered by the option as provided for
in this Section 19); provided however that if the consideration received in the
transaction is not solely common stock of the successor corporation or its
parent (as defined in Section 424(e) of the Code), the Board may, with the
consent of the successor corporation, provide for the consideration to be
received upon exercise of the option to be solely common stock of the successor
corporation or its parent equal in Fair Market Value to the per Share
consideration received by holders of Common Stock in the transaction.

     The Board may, if it so determines in the exercise of its sole discretion,
also make provision for adjusting the Reserves, as well as the price per Share
of Common Stock covered by each outstanding option, in the event that the
Company effects one or more reorganizations, recapitalizations, rights offerings
or other increases or reductions of Shares of its outstanding Common Stock, and
in the event of the Company's being consolidated with or merged into any other
corporation.

     20.  Amendment or Termination.
          ------------------------

          (a) The Board may at any time and for any reason terminate or amend
the Plan.  Except as provided in Section 19, no such termination of the Plan may
affect options previously granted, provided that the Plan or an Offering Period
may be terminated by the Board on a Purchase Date or by the Board's setting a
new Purchase Date with respect to an Offering Period and Purchase Period then in
progress if the Board determines that termination of the Plan and/or the
Offering Period is in the best interests of the Company and the stockholders or
if continuation of the Plan and/or the Offering Period would cause the Company
to incur adverse accounting charges as a result of a change after the effective
date of the Plan in the generally accepted accounting rules applicable to the
Plan.  Except as provided in Section 19 and in this Section 20, no amendment to
the Plan shall make any change in any option previously granted that adversely
affects the rights of any participant.  In addition, to the extent necessary to
comply with Rule 16b-3 under the Exchange Act, or under Section 423 of the Code
(or any successor

                                      -9-
<PAGE>

rule or provision or any applicable law or regulation), the Company shall obtain
stockholder approval in such a manner and to such a degree as so required.

          (b) Without stockholder consent and without regard to whether any
participant rights may be considered to have been adversely affected, the Board
(or its committee) shall be entitled to change the Offering Periods and Purchase
Periods, limit the frequency and/or number of changes in the amount withheld
during an Offering Period, establish the exchange ratio applicable to amounts
withheld in a currency other than U.S. dollars, permit payroll withholding in
excess of the amount designated by a participant in order to adjust for delays
or mistakes in the Company's processing of properly completed withholding
elections, establish reasonable waiting and adjustment periods and/or accounting
and crediting procedures to ensure that amounts applied toward the purchase of
Common Stock for each participant properly correspond with amounts withheld from
the participant's Compensation, and establish such other limitations or
procedures as the Board (or its committee) determines in its sole discretion
advisable that are consistent with the Plan.

     21.  Notices.  All notices or other communications by a participant to the
          -------
Company under or in connection with the Plan shall be deemed to have been duly
given when received in the form specified by the Company at the location, or by
the person, designated by the Company for the receipt thereof.

     22.  Conditions Upon Issuance of Shares.  Shares shall not be issued with
          ----------------------------------
respect to an option unless the exercise of such option and the issuance and
delivery of such Shares pursuant thereto shall comply with all applicable
provisions of law, domestic or foreign, including, without limitation, the
Securities Act of 1933, as amended, the Exchange Act, the rules and regulations
promulgated thereunder, applicable state securities laws and the requirements of
any stock exchange upon which the Shares may then be listed, and shall be
further subject to the approval of counsel for the Company with respect to such
compliance.

     As a condition to the exercise of an option, the Company may require the
person exercising such option to represent and warrant at the time of any such
exercise that the Shares are being purchased only for investment and without any
present intention to sell or distribute such Shares if, in the opinion of
counsel for the Company, such a representation is required by any of the
aforementioned applicable provisions of law.

     23.  Term of Plan; Effective Date.  The Plan shall become effective upon
          ----------------------------
the IPO Date.  It shall continue in effect for a term of twenty (20) years
unless sooner terminated under Section 20.

     24.  Additional Restrictions of Rule 16b-3.  The terms and conditions of
          -------------------------------------
options granted hereunder to, and the purchase of Shares by, persons subject to
Section 16 of the Exchange Act shall comply with the applicable provisions of
Rule 16b-3.  This Plan shall be deemed to contain, and such options shall
contain, and the Shares issued upon exercise thereof shall be subject to, such
additional conditions and restrictions as may be required by Rule 16b-3 to
qualify for the maximum exemption from Section 16 of the Exchange Act with
respect to Plan transactions.

                                      -10-
<PAGE>

                              CHEMDEX CORPORATION

                       1999 EMPLOYEE STOCK PURCHASE PLAN
                            SUBSCRIPTION AGREEMENT
                            ----------------------


                                                             New Election ______
                                                       Change of Election ______


     1.  I, ________________________, hereby elect to participate in the Chemdex
Corporation 1999 Employee Stock Purchase Plan (the "Plan") for the Offering
                                                    ----
Period ______________, ____ to _______________, ____, and subscribe to purchase
shares of the Company's Common Stock in accordance with this Subscription
Agreement and the Plan.

     2.  I elect to have Contributions in the amount of ____% of my
Compensation, as those terms are defined in the Plan, applied to this purchase.
I understand that this amount must not be less than 1% and not more than 20% of
my Compensation during the Offering Period.  (Please note that no fractional
percentages are permitted).

     3.  I hereby authorize payroll deductions from each paycheck during the
Offering Period at the rate stated in Item 2 of this Subscription Agreement.  I
understand that all payroll deductions made by me shall be credited to my
account under the Plan and that I may not make any additional payments into such
account.  I understand that all payments made by me shall be accumulated for the
purchase of shares of Common Stock at the applicable purchase price determined
in accordance with the Plan.  I further understand that, except as otherwise set
forth in the Plan, shares will be purchased for me automatically on the Purchase
Date of each Offering Period unless I otherwise withdraw from the Plan by giving
written notice to the Company for such purpose.

     4.  I understand that I may discontinue at any time prior to the Purchase
Date my participation in the Plan as provided in Section 10 of the Plan.  I also
understand that, unless otherwise provided by the Plan administrator, I can
increase or decrease the rate of my Contributions during a Purchase Period as
follows: 1) I can increase the rate of my Contributions for a Purchase Period,
other than the first Purchase Period of an Offering Period, by completing and
filing a new Subscription Agreement at least five (5) business days prior to the
first day of the applicable Purchase Period, with such rate change taking effect
on the first day of such Purchase Period; and 2) I can decrease the rate of my
Contributions on one occasion only during a Purchase Period, by completing and
filing a new Subscription Agreement , with such rate change taking effect with
the first full payroll following five (5) business days after the Company's
receipt of the new Subscription Agreement.  Further, I may change the rate of
deductions for future Offering Periods by filing a new Subscription Agreement,
and any such change will be effective as of the beginning of the next Offering
Period.  In addition, I

<PAGE>

acknowledge that, unless I discontinue my participation in the Plan as provided
in Section 10 of the Plan, my election will continue to be effective for each
successive Offering Period.

     5.  I have received a copy of the Company's most recent description of the
Plan and a copy of the complete "Chemdex Corporation 1999 Employee Stock
Purchase Plan."  I understand that my participation in the Plan is in all
respects subject to the terms of the Plan.

     6.  Shares purchased for me under the Plan should be issued in the name(s)
of (name of employee or employee and spouse only):

                                            ____________________________________

                                            ____________________________________

     7.  In the event of my death, I hereby designate the following as my
beneficiary(ies) to receive all payments and shares due to me under the Plan:


NAME:  (Please print)               ___________________________________________
                                    (First)       (Middle)        (Last)

_____________________               ___________________________________________
(Relationship)                      (Address)

                                    ___________________________________________


     8.  I understand that if I dispose of any shares received by me pursuant to
the Plan within 2 years after the Offering Date (the first day of the Offering
Period during which I purchased such shares) or within 1 year after the Purchase
Date, I will be treated for federal income tax purposes as having received
ordinary compensation income at the time of such disposition in an amount equal
to the excess of the fair market value of the shares on the Purchase Date over
the price that I paid for the shares, regardless of whether I disposed of the
shares at a price less than their fair market value at the Purchase Date. The
remainder of the gain or loss, if any, recognized on such disposition will be
treated as capital gain or loss.

     I hereby agree to notify the Company in writing within 30 days after the
     ------------------------------------------------------------------------
date of any such disposition, and I will make adequate provision for federal,
- -----------------------------------------------------------------------------
state or other tax withholding obligations, if any, that arise upon the
- -----------------------------------------------------------------------
disposition of the Common Stock.  The Company may, but will not be obligated to,
- -------------------------------
withhold from my compensation the amount necessary to meet any applicable
withholding obligation including any withholding necessary to make available to
the Company any tax deductions or benefits attributable to the sale or early
disposition of Common Stock by me.

     9.  If I dispose of such shares at any time after expiration of the 2-year
and 1-year holding periods, I understand that I will be treated for federal
income tax purposes as having

                                      -2-
<PAGE>

received compensation income only to the extent of an amount equal to the lesser
of (1) the excess of the fair market value of the shares at the time of such
disposition over the purchase price that I paid for the shares under the option,
or (2) 15% of the fair market value of the shares on the Offering Date. The
remainder of the gain or loss, if any, recognized on such disposition will be
treated as capital gain or loss.

     I understand that this tax summary is only a summary and is subject to
     ----------------------------------------------------------------------
change.  I further understand that I should consult a tax advisor concerning the
- ------
tax implications of the purchase and sale of stock under the Plan.

     10. I hereby agree to be bound by the terms of the Plan. The effectiveness
of this Subscription Agreement is dependent upon my eligibility to participate
in the Plan.



SIGNATURE:  ________________________

SOCIAL SECURITY #:  ________________

DATE:  _____________________________



SPOUSE'S SIGNATURE (necessary
if beneficiary is not spouse):



____________________________________
(Signature)



____________________________________
(Print name)

                                      -3-
<PAGE>

                              CHEMDEX CORPORATION

                       1999 EMPLOYEE STOCK PURCHASE PLAN

                             NOTICE OF WITHDRAWAL
                             --------------------

     I, __________________________, hereby elect to withdraw my participation in
the Chemdex Corporation 1999 Employee Stock Purchase Plan (the "Plan") for the
                                                                ----
Offering Period that began on _________ ___, _____.  This withdrawal covers all
Contributions credited to my account and is effective on the date designated
below.

     I understand that all Contributions credited to my account will be paid to
me within ten (10) business days of receipt by the Company of this Notice of
Withdrawal and that my option for the current period will automatically
terminate, and that no further Contributions for the purchase of shares can be
made by me during the Offering Period.

     The undersigned further understands and agrees that he or she shall be
eligible to participate in succeeding offering periods only by delivering to the
Company a new Subscription Agreement.


Dated:___________________                _______________________________________
                                         Signature of Employee


                                         _______________________________________
                                         Social Security Number


<PAGE>

                                                                   EXHIBIT 10.21

                                 OFFICE LEASE



                                by and between

                               ALZA CORPORATION


                                      and


                              CHEMDEX CORPORATION


                                 for space at


                               1010 JOAQUIN ROAD
                           MOUNTAIN VIEW, CALIFORNIA


                                August 13, 1999
<PAGE>

                               TABLE OF CONTENTS

<TABLE>
<S>                                                                                 <C>
BASIC LEASE PROVISIONS..........................................................     1
1.   DEFINITIONS................................................................     3
2.   TERM AND POSSESSION........................................................     5
3.   MONTHLY BASE RENT; NET LEASE...............................................     8
4.   LETTER OF CREDIT...........................................................     9
5.   TENANT'S PAYMENT OF PROPERTY TAXES AND INSURANCE PREMIUMS..................    11
6.   MAINTENANCE, REPAIR AND REPLACEMENT........................................    13
7.   IMPROVEMENTS AND ALTERATIONS; LIENS........................................    16
8.   USE OF PREMISES............................................................    18
9.   HAZARDOUS MATERIALS........................................................    19
10.  UTILITIES AND SERVICES.....................................................    23
11.  RULES AND REGULATIONS......................................................    26
12.  TAXES ON TENANT'S PROPERTY.................................................    27
13.  FIRE OR CASUALTY...........................................................    27
14.  EMINENT DOMAIN.............................................................    29
15.  ASSIGNMENT AND SUBLETTING..................................................    30
16.  ACCESS AND RESERVED RIGHTS.................................................    34
17.  SUBORDINATION AND ATTORNMENT...............................................    36
18.  TRANSFER OF PREMISES; QUIET ENJOYMENT......................................    37
19.  NONLIABILITY AND INDEMNIFICATION OF LANDLORD; INSURANCE....................    37
20.  WAIVER OF SUBROGATION......................................................    41
21.  ATTORNEYS' FEES............................................................    41
22.  WAIVER.....................................................................    41
23.  NOTICES....................................................................    42
24.  BANKRUPTCY.................................................................    42
25.  DEFAULT AND REMEDIES.......................................................    42
26.  HOLD OVER..................................................................    46
27.  CONDITION OF PREMISES......................................................    46
28.  QUIET POSSESSION...........................................................    47
29.  DAMAGE TO TENANT'S PROPERTY................................................    47
30.  CONFLICT OF LAWS...........................................................    47
31.  SUCCESSORS AND ASSIGNS.....................................................    47
32.  BROKERS....................................................................    47
33.  NEGOTIATED AGREEMENT.......................................................    48
34.  INTEREST ON TENANTS OBLIGATIONS; LATE CHARGE...............................    48
35.  TIME.......................................................................    49
36.  DEFINED TERMS AND MARGINAL HEADINGS........................................    49
37.  PRIOR AGREEMENTS...........................................................    49
38.  AUTHORITY OF PARTIES.......................................................    49
39.  NO LIGHT, AIR OR VIEW EASEMENT.............................................    50
40.  EXAMINATION OF LEASE.......................................................    50
41.  FORCE MAJEURE..............................................................    50
42.  RECORDING..................................................................    50
43.  INCORPORATION BY REFERENCE.................................................    51
</TABLE>
<PAGE>

<TABLE>
<S>                                                                                 <C>
44.  DEFINITION OF ADDITIONAL RENT..............................................    51
45.  SURRENDER OF PREMISES......................................................    51
46.  NO ACCORD AND SATISFACTION.................................................    52
47.  MERGER.....................................................................    52
48.  FINANCIAL STATEMENTS.......................................................    52
</TABLE>

EXHIBITS AND SCHEDULES
- ----------------------

A.     Legal Description
B.     Schedule of Monthly Base Rent
C.     Letter of Credit
D.     Work Letter for Tenant Improvements
E.     Nondisturbance Agreement

1.     List of Remaining Furniture
2.     List of Groundwater Monitoring Report
3.     Site Plan Showing Entrances and Corridors
<PAGE>

                                     LEASE

          THIS LEASE ("Lease") is made this 13th day of August, 1999 by and
between ALZA CORPORATION, a Delaware Corporation ("Landlord"), and CHEMDEX
CORPORATION, a Delaware corporation ("Tenant").

          Landlord hereby leases to Tenant and Tenant hereby hires from
Landlord, subject to all of the terms and conditions hereinafter set forth,
those certain premises described in Item 6 of the Basic Lease Provisions and
located on the Second Floor of 1010 Joaquin Road, Mountain View, California.


                    BASIC LEASE PROVISIONS
                    ----------------------

1.    Date:         August 13, 1999
      ----

2.    Tenant:       CHEMDEX CORPORATION, a Delaware corporation
      ------

3.    Address:      Before Commencement Date:
      -------       3950 Fabian Way
                    Palo Alto, California 94303
                    Attention: Steve Draper, Director of Corporate Operations


                    After Commencement Date:

                    1550 Plymouth Street
                    Mountain View, California 94043
                    Attention: Steve Draper, Director of Corporate Operations

4.   Landlord:      ALZA CORPORATION, a Delaware corporation
     --------

5.   Address:       950 Page Mill Road
     -------        Palo Alto, California 94304
                    Attention: Senior Vice President and General Counsel


6.   Premises:      The second floor of the two-story freestanding
     --------       building located at 1010 Joaquin Road, Mountain View,
                    California, containing approximately 26,445 rentable square
                    feet (RSF), together with the parking areas, driveways,
                    landscaping, common areas and other appurtenances
                    constructed or located on or serving the 1010 Joaquin Road
                    building (the "Premises"). The real property on which the
                    Premises is located is more particularly described in
                    Exhibit A attached hereto and incorporated herein by this
                    ----------
                    reference.

7.   Term:          Approximately five (5) years and one (1) month (See Article
     ----
                    2)

                                      -1-
<PAGE>

8.   Monthly Base Rent:  The following Monthly Base Rent for the Premises shall
     -----------------   be payable on a triple net basis pursuant to Section
                         3.1 below: From the Commencement Date until October 14,
                         2000, Seventy-Five Thousand Three Hundred Sixty-Eight
                         Dollars ($75,368) per month. The Monthly Base Rent for
                         the remaining Lease years during the Term and each
                         Extended Term (if any) of this Lease shall be as set
                         forth on Exhibit B attached hereto and incorporated
                                  ---------
                         herein by this reference. Monthly Base Rent for the
                         Premises (but no other rent or charges due under this
                         Lease) shall be forgiven for the first month of the
                         Term.

9.   Prepaid Rent:       $75,368 due upon execution of the Lease by Landlord
     ------------        and Tenant (See Section 3.1)

10.  Letter of Credit:   Letter of Credit in the amount of Six Hundred
     ----------------    Twenty-Five Thousand Dollars ($625,000) due upon
                         execution of the Lease (See Article 4)

11.  Permitted Use:      As provided in Article 8
     -------------

12.  Renewal Options:    Subject to Landlord's Recapture Right (defined in
     ---------------     Section 2.3 below), two (2) successive one (1) year
                         renewal options (See Section 2.3)

13.  Expansion Options:  None
     -----------------

14.  Landlord's Broker:  Catalyst-CRESA Real Estate Group
     -----------------

15.  Tenant's Broker:    Cornish & Carey Commercial Real Estate
     ---------------

          The foregoing Basic Lease Provisions set forth the essential terms of
this Lease and should be read in conjunction with the rest of the Lease and in
particular, with reference to how those terms are defined in the Lease.

                                   ARTICLE 1

                                  DEFINITIONS
                                  -----------

          Unless otherwise specified, the following terms used in this Lease and
designated by initial capitals shall have the following meanings:

     1.1  "Environmental Laws" shall mean all local, state, or federal laws,
           ------------------
statutes, ordinances, rules, regulations, judgments, injunctions, stipulations,
decrees, orders, policies, permits, approvals, treaties, or protocols now or
hereafter enacted, issued or promulgated by any governmental authority which
relate to any Hazardous Material or the use, manufacture, handling, treatment,
transportation, production, disposal, discharge, distribution, release,
recycling, emission, sale, or storage of, or the exposure of any person to, a
Hazardous Material.

                                      -2-
<PAGE>

     1.2  "Financial Statements" shall mean the financial information contained
           --------------------
in Tenant's Initial Registration Statement on Form S-1 accessed by Landlord on
or about May 24, 1999 at www.freeedgar.com.

     1.3  "Force Majeure" shall mean any of the events described in Article 41,
           -------------
below.

     1.4  "Hazardous Material" shall mean any material or substance that is now
           ------------------
or hereafter prohibited or regulated by any statute, law, role, regulation or
ordinance or that is now or hereafter designated by any governmental authority
to be radioactive, toxic, hazardous or otherwise a danger to health,
reproduction or the environment including but not limited to (i) oil and
petroleum products, (ii) radioactive materials, (iii) asbestos and asbestos-
containing materials, (iv) polycholorinated biphenyls, and (v) viruses, microbes
and other biological materials and (v) substances defined as "hazardous
substances", "hazardous materials", or "toxic substances" in the Comprehensive
Environmental Response Compensation and Liability Act of 1980, as amended, 42
U.S.C. (S)(S)9601 et seq.; the Hazardous Materials Transportation Act, 49 U.S.C.
                  -- ---
(S)(S) 1801 et seq.; the Resource Conservation and Recovery Act, 42 U.S.C.
            -- ---
(S)(S) 6901, et seq.; the Toxic Substances Control Act, 15 U.S.C. (S)(S) 2601,
             -- ---
et seq.; the Clean Water Act, 33 U.S.C. (S)(S) 1251, et seq.; the California
- -- ---                                               -- ---
Hazardous Waste Control Act, Health and Safety Code (S)(S) 25330, et seq.; the
                                                                  -- ---
California Safe Drinking Water and Toxic Enforcement Act, Health and Safety Code
(S)(S) 25249.5, et seq.; California Health and Safety Code (S)(S) 25280, et seq.
                -- ---                                                   -- ---
(Underground Storage of Hazardous Substances); the California Hazardous Waste
Management Act, Health and Safety Code, (S)(S) 25170, et seq. (Hazardous
                                                      -- ---
Materials Release Response Plans and Inventory); the California Porter-Cologne
Water Quality Control Act, Water Code (S)(S) 13000, et seq.; all as amended.
                                                    -- ---

     1.5  "Hazardous Material Condition" shall mean the occurrence or discovery,
           ----------------------------
after the Commencement Date, of a condition involving the presence of, or a
contamination by, a Hazardous Material in or under the Premises requiring
remediation under Environmental Laws or rendering any part of the Premises
unsafe for human occupancy.

     1.6  "Joaquin Percentage Share" shall mean Forty-Nine and 39/100ths Percent
           ------------------------
(49.39%) which percentage is obtained by dividing the RSF of the Premises by the
total RSF of the 1010 Joaquin Road building (which equals 53,538 RSF).

     1.7  "Landlord Affiliate" shall mean any corporation, general or limited
           ------------------
partnership, joint venture, limited liability company or other person or entity
which controls, is controlled by or under common control with ALZA Corporation
or resulting from a merger or consolidation with ALZA Corporation or which
acquires substantially all of the assets of ALZA Corporation.

     1.8  "Landlord Parties" shall mean Landlord, its employees, agents,
           ----------------
consultants, licensees, invitees, contractors, subcontractors, and any other
person for whom Landlord is legally responsible, provided that under no
circumstances shall any of Tenant Parties be deemed a Landlord Party for
purposes of this Lease.

     1.9  "Lease" shall mean this Lease document including the Basic Lease
           -----
Provisions and any and all Exhibits and Addenda attached hereto now or in the
future

     1.10 "Letter of Credit" shall mean the Letter of Credit described in
           ----------------
Article 4 below.

                                      -3-
<PAGE>

     1.11  "Permitted Use" shall mean the sole use for which Tenant may utilize
            -------------
the Premises as specified in Item 11 of the Basic Lease Provisions and Article 8
below.

     1.12  "Plymouth Lease" shall mean the office lease of even date herewith
            --------------
executed by Landlord and Tenant for the Plymouth Premises.

     1.13  "Plymouth Premises" shall mean the 1500 Plymouth Street building
            -----------------
containing approximately 40,000 RSF and the 1550 Plymouth Street building also
containing approximately 40,000 RSF together with the parking areas, driveways,
landscaping, common areas and other appurtenances constructed or located thereon
or serving the 1500 Plymouth Street building and/or the 1550 Plymouth Street
building.

     1.14  "Premises" shall have the meaning set forth in Item 6 of the Basic
            --------
Lease Provisions.

     1.15  "Rent" and "rent" shall mean Monthly Base Rent, Additional Rent and
            ----
all other charges payable hereunder and under any Exhibit or Addenda to this
Lease, and any other monetary obligations of Tenant to Landlord under the
provisions of this Lease.

     1.16  "Technology Party" shall mean any corporation, general or limited
            ----------------
partnership, joint venture, limited liability company or other person or entity
which is pursuing the application of Landlord's technology as a material part of
its business pursuant to a written agreement with Landlord.

     1.17  "Tenant Affiliate" shall mean any corporation, general or limited
            ----------------
partnership, joint venture, limited liability company or other person or entity
(collectively, "person") which satisfies each of the following three criteria:
(i) such person controls, is controlled by or is under common control with
Tenant or results from a merger or consolidation with Tenant; (ii) Tenant
beneficially owns more than fifty percent (50%) of such person; and (iii) such
person has a net worth, determined in accordance with generally accepted
accounting principles ("GAAP"), in excess of Twenty Million Dollars
($20,000,000).

     1.18  "Tenant Subsidiary." shall mean any corporation, general or limited
            -----------------
partnership, joint venture, limited liability company or other person or entity
(collectively, "person") which satisfies each of the following two criteria: (i)
such person controls, is controlled by or is under common control with Tenant or
results from a merger or consolidation with Tenant; and (ii) Tenant beneficially
owns more than fifty percent (50%) of such person.

     1.19  "Tenant Parties" shall mean Tenant, its employees, agents,
            --------------
consultants, licensees, invitees, contractors, subcontractors, and any other
person for whom Tenant is legally responsible, provided that under no
circumstances shall any of Landlord Parties be deemed a Tenant Party for
purposed of this Lease.

     1.20  "Term" shall mean the period of the Lease between the Commencement
            ----
Date and the Expiration Date (as such Commencement Date and Expiration Date are
defined in Section 2.1 below) or earlier termination of the Lease, but not to
exceed the period set forth in Item 7 of the Basic Lease Provisions unless
extended as provided in Section 2.3 below.

                                      -4-
<PAGE>

     1.21  Other defined terms used in this Lease shall have the meanings set
forth in the Lease, including the following:

           1.21.1  "Additional Rent" is defined in Article 44;
                    ---------------

           1.21.2  "Commencement Date" is defined in Section 2.1;
                    -----------------

           1.21.3  "Expiration Date" is defined in Section 2.1; and
                    ---------------

           1.21.4  "Monthly Base Rent" is defined in Article 3.
                    -----------------

                                   ARTICLE 2

                              TERM AND POSSESSION
                              -------------------

     2.1  Commencement. The Term of this Lease shall be for approximately five
          ------------
(5) years and one (1) month as described in Item 7 of the Basic Lease Provisions
and shall commence on that date when Landlord delivers possession of the
Premises to Tenant in vacant, broom-clean condition, which Landlord anticipates
to occur on or about February 1, 2000 (the "Commencement Date"), and shall
expire on February 28, 2005 (the "Expiration Date"). Landlord shall exercise
commercially reasonable efforts (subject to Force Majeure delays) to deliver the
Premises to Tenant on or about February 1, 2000. Landlord shall exercise
commercially reasonable efforts to give Tenant at least thirty (30) days prior
written notice of each anticipated Commencement Date (but without any liability
on Landlord's part if Landlord shall fail to do so). Landlord and Tenant shall
execute a letter agreement confirming each exact Commencement Date within five
(5) business days following the Commencement Date. If the Commencement Date and
delivery of possession of the Premises to Tenant does not occur on or before
April 3, 2000, then Tenant's sole and exclusive remedy with respect to such
delay in the Commencement Date shall be to terminate this Lease and the Plymouth
Lease by written notice given to Landlord on or before April 17, 2000, and in
the event of such termination both Landlord and Tenant shall be released and
relieved of their respective obligations and liabilities under this Lease and
under the Plymouth Lease, Landlord shall return Tenant's prepaid rent and the
Letter of Credit paid or delivered by Tenant under this Lease and under the
Plymouth Lease to Tenant and neither party shall have any right to recover any
losses, costs, expenses or damages (including, without limitation, loss of
profits, foreseeable or unforeseeable consequential damages or special damages)
from the other party.

     2.2  Tenant's Acceptance of Possession. Tenant acknowledges and agrees that
          ---------------------------------
(i) Tenant has made all investigations which Tenant deems necessary concerning
(A) the condition of the Premises including the soil, air and groundwater
thereof, (B) Landlord's prior use of the Premises, (C) Landlord's prior and
continuing use of the ground floor of the 1010 Joaquin building for research and
development, laboratory and pharmaceutical purposes, (D) the adequacy of parking
for Tenant's intended office use of the Premises, (E) the compliance of the
Premises with all applicable statutes, laws, ordinances and regulations and (F)
Tenant's ability to operate its business in the Premises, (ii) Tenant shall
accept the Premises in "AS IS" and "WITH ALL FAULTS" condition on the
Commencement Date subject to all applicable zoning, municipal, county, state and
federal statutes, laws, ordinances and regulations governing and

                                      -5-
<PAGE>

regulating the use of the Premises and all easements, encumbrances, covenants,
conditions and restrictions of record, (iii) except as otherwise provided in
this Lease, Landlord has no obligation to alter or improve the Premises of any
nature whatsoever and (iv) Tenant acknowledges and agrees that neither Landlord
nor any of its agents or representatives has made any oral or written
representations or warranties of any nature whatsoever (a) with respect to the
Premises including the soil, air and groundwater thereof, (b) compliance or the
Premises with building codes and applicable laws, (c) the ability of Tenant to
operate its business in the Premises or (d) as to any of the matters set forth
in subclauses (i)(A) through (i)(F) above.

     2.3  Option To Extend Term. Landlord shall notify Tenant in writing at
          ---------------------
least twelve (12) months prior to the Expiration Date of the initial Term of the
Lease and/or twelve (12) months prior to the expiration of the first Extended
Term (defined below), as applicable, as to whether Landlord will exercise its
right to repossess the Premises from and after the Expiration Date or the
expiration of the first Extended Term, as applicable (the "Recapture Right"). If
Landlord, in Landlord's sole and absolute discretion, exercises this Recapture
Right, then (i) the Lease shall terminate on the Expiration Date or the
expiration of the first Extended Term, as applicable, (ii) Tenant shall have no
right to extend this Lease for the Extended Term(s) (defined below), (iii) from
and after the Expiration Date or the expiration of the first Extended Term, as
applicable, Tenant shall have no further rights or interests in the Premises of
any nature whatsoever, and (iv) provided Landlord, a Landlord Affiliate and/or a
Technology Party initially occupies more than fifty percent (50%) of the
Premises for their own use, Landlord shall be free to use the balance of the
Premises for any purposes whatsoever, including, without limitation, assigning
or subleasing the balance of the Premises to any person or entity for any
purpose whatsoever. If Landlord does not timely exercise its Recapture Right as
to the Premises upon the Expiration Date or the expiration of the first Extended
Term, as applicable, then Tenant shall have the option to extend the term of
this Lease as to the entire Premises (but not less than the entire Premises) for
two (2) extended term(s) of one (1) year each commencing upon the Expiration
Date of the initial Term of the Lease and the expiration of the first one-year
Extended Term (each, an "Extended Term"). Tenant may exercise the foregoing
option to extend if and only if (i) Tenant notifies Landlord in writing of its
irrevocable election to extend the Term of the Lease for the Extended Term no
later than eleven (11) months prior to the Expiration Date of the initial Term
of the Lease or eleven (11) months prior to the expiration date of the first
one-year Extended Term, as applicable, (ii) Tenant extends the term with respect
to the entire Premises (and not solely a portion of the Premises) and (iii)
Tenant is not in material default of the Lease (following the expiration of any
applicable cure periods without cure) either at the time of giving notice of its
irrevocable election to extend or on the commencement date of each Extended
Term. If each of the conditions set forth in the immediately preceding sentence
are not satisfied in full, then Tenant's option(s) to extend the term of the
Lease shall lapse and be null and void and the terms and provisions of the
second sentence of this Section 2.3 shall apply as though Landlord had exercised
its Recapture Right as to the Premises. All of the terms and provisions of this
Lease shall apply during the Extended Term except that (a) there shall be no
further right to extend the term of the Lease beyond the second Extended Term,
(b) except as expressly provided in this Lease, Landlord shall have no
obligation to make improvements to the Premises of any nature whatsoever, (c)
Tenant shall not be entitled to any abatement of Monthly Base Rent during either
Extended Term and (d) Monthly Base Rent during each the Extended Term shall be
determined and annually increased in accordance with the provisions of Exhibit B
                                                                       ---------
attached hereto. The foregoing right to extend the term of the Lease is personal
to Tenant and

                                      -6-
<PAGE>

may not be assigned, sold, leased or otherwise transferred, voluntarily or
involuntarily, by or to any other person or entity except to a Tenant Affiliate
in accordance with Article 15 below.

     2.4  Access to Premises. During the Term and any Extended Term(s), Tenant
          ------------------
shall at all times have access to the Premises through the 1010 Joaquin building
entrances and corridors shown on the site plan attached hereto as Schedule 3.
                                                                  ----------

                                   ARTICLE 3

                         MONTHLY BASE RENT; NET LEASE
                         ----------------------------

     3.1  Monthly Base Rent. Tenant shall pay to Landlord as Monthly Base Rent
          -----------------
for the Premises the sum(s) described in Item 8 of the Basic Lease Provisions
and as set forth on Exhibit B to this Lease during the entire Term and any
                    ----------
Extended Term(s). The Monthly Base Rent shall be payable in advance on the first
day of each calendar month, without deduction, setoff, abatement, prior notice
or demand, commencing on the Commencement Date and continuing for each calendar
month thereafter during the Term of the Lease and the Extended Term(s), if
applicable. In the event the Term of this Lease commences or ends on a day other
than the first or last day of a calendar month, then the Monthly Base Rent for
such partial month shall be prorated in the proportion that the number of days
this Lease is in effect during such partial month bears to the number of days in
that calendar month, and such Monthly Base Rent shall be paid at the
commencement of such partial month. Monthly Base Rent shall be payable in lawful
money of the United States at the address of Landlord set forth in Item 5 of the
Basic Lease Provisions or at such other address as may be designated by Landlord
in writing pursuant to Article 23 below. Notwithstanding any other term of this
Lease to the contrary, a prepayment of Monthly Base Rent in the amount set forth
in Item 9 of the Basic Lease Provisions shall be made by Tenant upon execution
of this Lease and shall be applied to the Monthly Base Rent for the second (2nd)
full calendar month of the Term. Landlord hereby acknowledges receipt of such
prepaid rent from Tenant.

     3.2  Forgiveness of Monthly Base Rent. As an inducement to Tenant to enter
          --------------------------------
into this Lease, Tenant shall be entitled to unconditional forgiveness of
Monthly Base Rent in the amount of $75,368 for the Premises for the first (1st)
month of the Term ("Forgiven Rent"). There shall be no abatement of Monthly Base
Rent during either Extended Term of this Lease. Tenant's obligation to pay in
full all Additional Rent and all other charges payable under this Lease shall
not be affected by the foregoing Forgiven Rent.

     3.3  Additional Rent. In addition to the Monthly Base Rent reserved in
          ---------------
Section 3.1 above, Tenant shall reimburse to Landlord or pay to the parties
entitled thereto, as applicable, the Joaquin Percentage Share of all
impositions, Insurance Premiums (as defined in Section 5.3 below), Property
Taxes (as defined in Section 5.2 below), operating charges, maintenance charges,
construction costs, and any other charges, costs and expenses which arise or may
be contemplated under any provisions of this Lease during the Term hereof and
each Extended Term on the terms set forth in this Lease. All of such charges,
costs and expenses shall constitute Additional Rent, and upon the failure of
Tenant to timely reimburse or pay any of such costs, charges or expenses,
Landlord shall have the same rights and remedies as otherwise provided in this
Lease for the failure of Tenant to pay rent. It is the intention of the parties

                                      -7-
<PAGE>

hereto that this Lease shall not be terminable for any reason by Tenant except
for Landlord's uncured material breach of this Lease as provided in Section 25.3
below and except as otherwise expressly provided herein and that Tenant shall in
no event be entitled to any abatement of or reduction in Rent payable under this
Lease except as herein expressly provided. Any present or furore law to the
contrary shall not alter this agreement of the parties.

                                   ARTICLE 4

                               LETTER OF CREDIT
                               ----------------

     4.1  Letter of Credit as Security. Concurrent with the execution of this
          ----------------------------
Lease, Tenant shall deliver to Landlord the Letter of Credit (as defined in
Section 4.2 below) in the amount of Six Hundred Twenty-Five Thousand Dollars
($625,000), which Letter of Credit shall secure the full and faithful
performance of each and every provision and condition of this Lease to be
performed by Tenant. The amount of the Letter of Credit shall be reduced to Two
Hundred Fifty Thousand Dollars ($250,000) on February 1, 2002 if Tenant's net
worth on such date (determined in accordance with generally accepted accounting
principals ("GAAP")) exceeds Twenty Million Dollars ($20,000,000) and (ii) the
amount of the Letter of Credit shall be further reduced to One Hundred Twenty-
Five Thousand Dollars ($125,000) on February 1, 2003 if Tenant's net worth on
such date (determined in accordance with GAAP) continues to exceed Twenty
Million Dollars ($20,000,000). There shall be no further reduction in the stated
amount of the Letter of Credit from and after February 1, 2003. The face amount
of the Letter of Credit (as reduced above from time to time upon satisfaction of
the foregoing conditions) is hereafter referred to as the "Face Amount".
Anything contained in this Article 4 to the contrary notwithstanding, the Face
Amount of the Letter of Credit shall not be reduced if Tenant has previously
committed an uncured default under this Lease. If an Event of Default occurs
under this Lease (including but not limited to an Event of Default with respect
to the obligation to pay Rent or to clean and restore the Premises upon
termination of the Lease), Landlord may, but shall not be required to, draw upon
the Letter of Credit for the payment of any Rent, interest, late charges or any
other sum in default, or for the payment of any other amount which Landlord may
spend or become obligated to spend by reason of the Event of Default or to
compensate Landlord for any other loss or damage which Landlord may suffer by
reason of the Event of Default, including, without limitation, costs and
reasonable attorneys' fees incurred by Landlord to collect on the Letter of
Credit and/or to recover possession of the Premises following an Event of
Default by Tenant hereunder. Tenant shall cause the Letter of Credit to remain
in effect during the entire Term of this Lease and for an additional period of
sixty (60) days following the expiration or earlier termination of this Lease.
If Tenant fails to maintain, renew or replace the Letter of Credit in its then
Face Amount at least thirty (30) days before its stated expiration date (or if
Tenant fails to maintain, renew or replace the letter of credit under Article 4
of the Plymouth Lease in its then face amount at least thirty (30) days before
its stated expiration date), then Landlord may, without prejudice to any other
right or remedy, draw upon the entire amount of the Letter of Credit. Any amount
drawn by Landlord on the Letter of Credit pursuant to this Section 4.1 but not
applied by Landlord to satisfy Tenant's obligations hereunder shall be held by
Landlord as a security deposit. Landlord may commingle any proceeds from the
Letter of Credit with Landlord's general funds and Tenant shall not be entitled
to any interest thereon. If Landlord draws on any portion of the Letter of
Credit, Tenant shall, within three (3) business days after demand by Landlord,
either (a) deposit immediately available funds with Landlord in

                                      -8-
<PAGE>

the amount that when added to the remaining amount of the undrawn portion of the
Letter of Credit equals its then Face Amount or (b) deliver to Landlord written
documentation acceptable to Landlord executed by the Issuing Bank (as defined in
Section 4.2 below) confirming that the Issuing Bank has reinstated the Letter of
Credit to its then full Face Amount; and Tenant's failure to do either (a) or
(b) above shall constitute an Event of Default hereunder. If the funds received
by Landlord pursuant to a draw on the Letter of Credit exceed the amount applied
by Landlord to cure the Event of Default, concurrently with and conditioned upon
Tenant's reinstatement of the Letter of Credit to its full Face Amount, Landlord
shall return any such excess funds to Tenant. If Tenant shall fully perform each
and every provision of this Lease required by Tenant to be performed, the Letter
of Credit (and any funds held by Landlord as a security deposit after drawing on
the Letter of Credit) shall be returned to Tenant (or, at Landlord's option, to
the last assignee of Tenant's interest hereunder) within sixty (60) days
following the later of the expiration of the Term or surrender of possession of
the Premises to Landlord. Notwithstanding the foregoing, the Letter of Credit
(and any funds held by Landlord as a security deposit after drawing on the
Letter of Credit) shall be immediately returned to Tenant upon the termination
of this Lease solely by reason of Landlord's material default hereunder. Tenant
shall not assign or encumber the Letter of Credit. Any attempt to do so shall be
void and Landlord shall not be bound by any such purported assignment or
encumbrance. In the event of bankruptcy or other insolvency proceedings filed by
or against Tenant, all sums drawn under the Letter of Credit shall be deemed to
be applied first to the payment of Rent and other charges due Landlord for all
periods prior to the effective date of such proceedings. If Landlord transfers
or assigns its interest in the Premises, Landlord may transfer or assign the
Letter of Credit to such transferee.

     4.2  Form of Letter of Credit. Concurrent with the execution of this Lease,
          ------------------------
Tenant shall deliver to Landlord an irrevocable, unconditional standby letter of
credit in the original face amount of Six Hundred Twenty-Five Thousand Dollars
($625,000) in the form attached hereto as Exhibit C (the "Letter of Credit") to
                                          ---------
secure the full and faithful performance of each and every term and provision of
this Lease to be performed by Tenant as set forth in Section 4.1 above. The
Letter of Credit shall be issued by a bank or financial institution ("Issuing
Bank") which is acceptable to Landlord and which accepts deposits, maintains
accounts, is FDIC insured and has a local Mountain View or San Francisco office
which will negotiate the Letter of Credit. The Letter of Credit shall permit
full or partial draws by Landlord or Landlord's assignee. Tenant shall pay all
expenses, points or fees incurred by Tenant in obtaining, maintaining and
renewing the Letter of Credit. As provided in Section 4.1 above, Tenant shall
cause the Letter of Credit to remain in full force and effect during the entire
term of this Lease and for a period of sixty (60) days following the expiration
or earlier termination of this Lease (except in the case of termination of this
Lease solely by reason of Landlord's material default hereunder). Provided this
Lease has not expired or terminated, Tenant shall replace or renew the Letter of
Credit from time to time at least thirty (30) days before its stated expiration
date. Failure to so replace or renew the Letter of Credit shall constitute a
default hereunder and Landlord shall thereafter be entitled to draw the full
amount of the Letter of Credit and hold it as a cash security deposit. The terms
of the Letter of Credit shall expressly provide that the Letter of Credit is
assignable by Landlord, as beneficiary thereunder, to any transferee or assignee
of Landlord's interest in the Premises who expressly assumes in writing
Landlord's obligations under this Lease.

                                      -9-
<PAGE>

                                   ARTICLE 5

                      TENANT'S PAYMENT OF PROPERTY TAXES
                            AND INSURANCE PREMIUMS
                            ----------------------

     5.1  Payment of Property Taxes and Insurance Premiums. In addition to
          ------------------------------------------------
payment of Monthly Base Rent pursuant to Section 3.1 above, Tenant shall
reimburse on the terms set forth in this Article 5 to Landlord, as part of
Additional Rent hereunder, the Joaquin Percentage Share of Property Taxes (as
defined in Section 5.2 below) and Insurance Premiums (as defined in Section 5.3
below). Tenant shall reimburse Landlord for the Joaquin Percentage Share of
Property Taxes paid by Landlord for the Premises within ten (10) business days
following Tenant's receipt from Landlord of written demand for reimbursement of
such Property Taxes accompanied by a copy of the then applicable tax bill and a
copy of Landlord's check made payable to the taxing authority. Tenant shall
likewise reimburse Landlord for the Joaquin Percentage Share of Insurance
Premiums paid by Landlord for the Premises within ten (10) business days
following Tenant's receipt from Landlord of written demand for reimbursement of
such Insurance Premiums accompanied by a copy of the applicable insurance
premium invoice and a copy of Landlord's check made payable to the insurance
carrier. If any Property Taxes or Insurance Premiums so paid by Landlord cover
any period of time prior to or after the expiration of the Term hereof, Tenant's
share of Property Taxes or Insurance Premiums shall be equitably prorated to
reflect only the period of time during which the Lease was in effect.

     5.2  Property Taxes Defined. The term "Property Taxes" as used herein shall
          ----------------------
mean and include (i) any and all real estate and personal property taxes and
other taxes, rates, charges, general and special assessments, transit charges,
housing fund assessments, liens, assessment bonds, district formation costs,
bonds, levies, fees and impositions whether general, special or supplemental,
unforeseen or foreseen, ordinary or extraordinary which are assessed, imposed,
charged, confirmed or levied with respect to the Premises, and/or any
improvements, fixtures and equipment and other property of Landlord, real or
personal, located thereon, but only to the extent each of the foregoing relates
to the period between the Commencement Date (as applicable) and the date this
Lease expires or sooner terminates and any costs, fees or expenses incurred in
contesting the amount or validity of any of the foregoing; (ii) any tax,
surcharge, levy, fee or assessment which may be imposed in addition to or in
lieu of real estate or personal property taxes against the Premises, but only to
the extent each of the foregoing relates to the period between the Commencement
Date (as applicable) and the date this Lease expires or sooner terminates; and
(iii) any service, use or other fee collected by governmental agencies in
addition to or in lieu of real estate or personal property taxes against the
Premises for services provided by such agencies, but only to the extent each of
the foregoing relates to the period between the Commencement Date (as
applicable) and the date this Lease expires or sooner terminates. The term
Property Taxes as used herein shall also include any new, replacement or
supplemental property taxes and any rental, excise, sales, mortgage, transaction
privilege, or other tax or levy, however denominated, imposed upon or measured
by the rental reserved hereunder or on Landlord's business of owning, operating
or leasing the Premises, but only to the extent each of the foregoing relates to
the period between the Commencement Date (as applicable) and the date this Lease
expires or sooner terminates. However, notwithstanding anything to the contrary
above or elsewhere in this Lease, the term "Property Taxes" shall not mean or
include (a) any income, franchise, capital stock, estate or inheritance taxes of
or

                                      -10-
<PAGE>

applicable to Landlord; (b) any transfer taxes; or (c) any tax, fee, levy,
assessment or charge, or any increase therein, imposed by reason of any
alteration or improvement made to any portion of the 1010 Joaquin building
(other than the Premises) during the Term or any Extended Term or by reason of
any specific use made by Landlord (or any tenant of Landlord) during the Term or
any Extended Term of any portion of the 1010 Joaquin building (other than the
Premises). Subject to subclause (c) of the preceding sentence, Property Taxes
shall also include all increases in Property Taxes during the Term or Extended
Term including, without limitation, (a) annual increases, (b) increases due to a
reassessment of the Premises arising from a change in ownership or transfer of
all or part of Landlord's interest in the Lease, or the Premises or any
refinancing of the Premises or (c) any new construction, alterations or
renovations to the Premises or any of its common areas. If any Property Taxes
shall be payable in installments over a period of time extending beyond the Term
of the Lease (or the Extended Term, if applicable), Tenant shall only be
required to pay such installments thereof as shall become due and payable
during, or relate to periods of time covered by, the Term of the Lease (or any
Extended Term, if applicable). Landlord shall provide Tenant with a copy of its
annual Property Tax statements.

     5.3  Insurance Premiums. The term "Insurance Premiums" shall mean and
          ------------------
include all premiums paid or incurred by Landlord in obtaining and maintaining
the insurance coverages required to be maintained by Landlord under Section 19.4
below and other commercially reasonable insurance coverages which Landlord
acting as a prudent landowner and landlord may obtain and maintain, but only to
the extent such premiums paid for insurance coverage relate to the period
between the Commencement Date (as applicable) and the expiration or sooner
termination of this Lease.

                                   ARTICLE 6

                      MAINTENANCE, REPAIR AND REPLACEMENT
                      -----------------------------------

     6.1  Tenant's Obligations for the Premises. Except for the obligations of
          -------------------------------------
Landlord under Section 6.3, Section 9.2, Article 13 and Article 14 below, and
except for damage caused by Landlord or the Landlord Parties (which shall be the
sole and exclusive responsibility and cost of Landlord), Tenant, at Tenant's
sole cost and expense, shall keep in good and neat order, condition and repair
the interior nonstructural portions of the Premises, whether or not capital in
nature (and whether or not the interior nonstructural portions of the Premises
requiting repair or replacement, or the means of repairing or replacing the
same, are reasonably accessible to Tenant, and whether or not the need for
repairs, replacements and/or capital improvements occurs as a result of Tenant's
use, any prior use, the elements or age of such nonstructural portion of the
Premises, or alterations, additions, repairs or replacements required by
governmental authority, whether or not related to Tenant's specific use of the
Premises) including, without limitation, repair and replacement (including any
and all replacements and capital improvements) of all interior surfaces of
exterior walls and all surfaces of interior beating walls, all interior non-
beating walls, ceilings, lighting, cabling, data and telephone systems and
wiring, floors, windows, floor coverings and window coverings, doors and plate
glass of the Premises; provided, however, that the cost of any capital
improvements or replacements having a useful life (as determined in accordance
with GAAP) longer than the Lease Term (including the Extended Term(s), if any),
shall be amortized over such useful life and Tenant shall only be obligated to
pay, each month during the remainder of the Term (and Extended Term(s), if any)

                                      -11-
<PAGE>

on the date on which Base Monthly Rent is due, an amount equal to the product
obtained by multiplying the cost of such capital improvement or replacement by a
fraction, the numerator of which is one, and the denominator of which is the
number of months of the useful life of such capital improvement or replacement
(as such useful life is determined in accordance with GAAP), with Tenant
reserving the right to prepay its obligation at any time. Within ten (10)
business days after written demand from Tenant, Landlord shall reimburse Tenant
in full for the cost of any capital improvements or replacements made to the
Premises by Tenant pursuant to this Section 6.1.

     6.2  Landlord's Rights. If an Event of Default involving Tenant's failure
          -----------------
to perform Tenant's obligations under Section 6.1 above or under any other
Section of this Lease should occur, Landlord may at its option (but shall not be
required to) enter upon the Premises upon ten (10) business days prior written
notice to Tenant (except in an emergency, in which case no notice shall be
required) to cure such Event of Default on Tenant's behalf, and all reasonable
costs thereof together with interest thereon as set forth in Section 34.1 below
shall constitute Additional Rent hereunder and shall be due and payable within
five (5) business days after written demand by Landlord. Notwithstanding the
foregoing, in the case of an emergency resulting from Tenant's failure to
perform its obligations under Section 6.1 above or under any other Section of
this Lease, Landlord may act immediately pursuant to this Section 6.2.

     6.3  Landlord's Obligations for the Premises. Except for damage caused by
          ---------------------------------------
Tenant or the Tenant Parties (which shall be the sole and exclusive
responsibility and cost of Tenant), Landlord shall keep in good and neat order,
condition and repair all exterior and structural portions of, and all building
systems and common area within or serving, the Premises, whether or not capital
in nature including, without limitation, repair and replacement (including any
and all replacements and capital improvements) of all plumbing, electrical,
heating, ventilating and air conditioning systems, all elevators, stairways and
stairwells, all sprinkler and life safety systems, bearing walls (interior and
exterior), foundations, roofs and roof membranes, and all landscaping,
landscaping and irrigation systems, driveways, parking lots, loading docks,
fences and signs located on or adjacent to the Premises and all sidewalks and
pathways located on or adjacent thereto (with the cost of all of the foregoing
being referred to herein as the "Joaquin Maintenance Costs"). Landlord shall
periodically (but not more often than monthly) invoice to Tenant, and Tenant
shall reimburse to Landlord within ten (10) business days following Tenant's
receipt of Landlord's invoice, Tenant's Joaquin Percentage Share of the Joaquin
Maintenance Costs; provided, however, that the cost of any capital improvements
or improvements made by Landlord to the Premises having a useful life (as
determined in accordance with GAAP) longer than the Lease Term (including the
Extended Term(s), if any) shall be amortized over such useful life and Landlord
shall include within the Joaquin Maintenance Costs each month during the
remainder of the Term (and Extended Term(s), if any) an amount not to exceed to
the product obtained by multiplying the cost of such capital improvement or
replacement by a fraction, the numerator of which is one, and the denominator of
which is the number of months of the useful life of such capital improvement or
replacement (as such useful life is determined in accordance with GAAP), with
Tenant reserving the right to prepay its obligation at any time. Notwithstanding
the foregoing, except for damage caused by Tenant or the Tenant Parties (which
shall be the sole and exclusive responsibility and cost of Tenant), (a) the cost
of keeping the roof and roof membrane at the Premises, the skylights (if any) at
the Premises, the foundation for the Premises, and the structural walls
(including, without limitation, interior and exterior bearing

                                      -12-
<PAGE>

walls) at the Premises, in good and neat order, condition and repair (including
replacements and capital improvements), shall be borne exclusively by Landlord
and shall not be included in the Joaquin Maintenance Costs, and (b) the cost of
investigating, monitoring, remediating, removing or otherwise responding to any
Hazardous Materials on, under or about the Premises shall not be included in the
Joaquin Maintenance Costs (provided, however, that nothing herein shall be
deemed to limit Landlord's rights under Sections 9.3 through 9.5 below).

     6.4  Waivers. Except as expressly provided in Articles 13 and 14 below,
          -------
there shall be no abatement of Rent and no liability of Landlord by reason of
any injury to or interference with Tenant's business arising from Tenant's
making repairs pursuant to Section 6.1 above or Landlord making repairs pursuant
to Section 6.2 above (where Tenant has failed to make such repairs) and Section
6.3 above. Tenant expressly waives the benefit of any statute, law or regulation
now or hereafter in effect, including, without limitation, California Civil Code
Sections 1941 and 1942, which would otherwise afford Tenant the right to make
repairs at Landlord's expense or terminate the Lease.

                                   ARTICLE 7

                      IMPROVEMENTS AND ALTERATIONS; LIENS
                      -----------------------------------

     7.1  Original Tenant Improvements. On the Commencement Date Landlord shall
          ----------------------------
deliver possession of the Premises to Tenant in "AS IS" and "WITH ALL FAULTS"
condition. Tenant, at Tenant's sole cost and expense, shall construct and
install all of the Tenant Improvements (as defined in the Work Letter for Tenant
Improvements attached to this Lease as Exhibit D and incorporated herein by this
                                       ---------
reference (the "Work Letter")) within the Premises in a first-class, diligent
and workmanlike manner and fully and timely comply with each and every term,
covenant and condition set forth in the Work Letter. Tenant shall exercise its
best efforts to install within the Premises Tenant Improvements which will have
a remaining useful life to Landlord at the expiration or earlier termination of
the Lease.

     7.2  Furniture and Telephone/Network Equipment. During the Term and any
          -----------------------------------------
Extended Term(s) of the Lease, Landlord shall permit Tenant to use all of
Landlord's existing cubicles, office furniture and lobby/conference room
furniture (but excluding all ergonomic furniture and all exam room furniture in
Landlord's health clinic) listed on Schedule 1 attached to this Lease in its
                                    ----------
"AS-IS" and "WITH ALL FAULTS" condition (collectively, the "Remaining
Furniture") (but expressly excluding from the Remaining Furniture Landlord's
office equipment, fixtures and trade fixtures, which Landlord shall remove from
the Premises prior to the Commencement Date). Tenant shall be permitted to use
the Remaining Furniture at no additional rental. Prior to the Commencement Date,
Landlord and Tenant shall jointly make a detailed inspection and written
inventory of the Remaining Furniture to ensure that Schedule 1 both (i) properly
                                                    ----------
describes all of the Remaining Furniture and (ii) properly describes the
physical condition of the Remaining Furniture as of the Commencement Date.
Tenant, at Tenant's sole cost and expense, shall maintain the Remaining
Furniture in as good condition and repair as when received and at the expiration
or earlier termination of the Term of the Lease, Tenant shall return the
Remaining Furniture to Landlord in as good a condition as received, ordinary
wear and tear and damage by fire, other casualty or acts of God excepted. The
Remaining Furniture shall at all times during the Term and any Extended Term(s)
be and remain the sole and exclusive

                                      -13-
<PAGE>

property of Landlord; provided, however, that Tenant, at Tenant's sole cost and
expense, shall be obligated to insure the Remaining Furniture under its "All-
Risk" property insurance policy described in Section 19.3 below. Any and all
insurance proceeds relating to the Remaining Furniture shall be the sole and
exclusive property of Landlord. Landlord and Tenant hereby agree that the value
of the Remaining Furniture for insurance purposes only is Eight Hundred Fifty
Six Thousand One Hundred Ninety DOLLARS ($856,190.00). Tenant agrees that the
                                        -------------
Remaining Furniture shall remain within the Premises and that in no event shall
the Remaining Furniture be removed from the Premises. In addition, on the
Commencement Date Landlord shall leave in place within the Premises Landlord's
telephone lines and cable/network lines; provided, however, that Tenant
acknowledges and agrees that (a) on or before the Commencement Date Landlord
shall disconnect all such telephone lines and cable/network lines from
Landlord's central telephone/data network switch room located in the Premises
(the "Switch Room"), (b) Landlord shall have sole and exclusive use of and
unrestricted access through the Premises to the Switch Room in the Premises at
all times during the Term and any Extended Term(s) and (c) Tenant, at Tenant's
sole cost and expense, and as part of Tenant's installation of its Tenant
Improvements under the Work Letter, shall install its own dedicated central
telephone/data network switch room and connect its telephone and data network
cabling lines to its central telephone/data network switch room.

     7.3  Alterations by Tenant. Other than the initial Tenant Improvements,
          ---------------------
Tenant shall make no alterations, additions or improvements to the Premises
without the prior written consent of Landlord, which consent shall not be
unreasonably withheld or delayed. Landlord may impose, as a condition of such
consent, such reasonable requirements as Landlord may deem desirable including,
without limitation, the requirement that Tenant remove such alterations,
additions or improvements upon the expiration or earlier termination of the
Lease. Landlord shall advise Tenant in writing at the time Tenant makes its
initial Tenant Improvements under the Work Letter (as to the initial Tenant
Improvements) and at the time Tenant request's Landlord's consent to any
subsequent alterations whether Landlord will require Tenant to remove such
alterations from the Premises upon the expiration or earlier termination of this
Lease. Notwithstanding the requirements in this Section 7.3, nonstructural
alterations, additions or improvements which do not affect building systems or
the exterior of the Premises and that cost less than Fifty Thousand Dollars
($50,000) in the aggregate in any calendar year shall not require Landlord's
prior written consent, but Landlord shall be entitled to at least ten (10) days
prior written notice thereof before Tenant commences such alterations, additions
or improvements. Tenant shall submit all plans and specifications relating to
any proposed alterations, additions or improvements which exceed Fifty Thousand
Dollars ($50,000) in the aggregate in any calendar year to Landlord for
Landlord's prior written approval. No materials used in Tenant's alterations
shall be subject to any security interest or lien and no part of the Premises
shall be subject to any mechanics' or materialmen's lien by reason of Tenant's
alterations. No such alterations shall affect the exterior appearance of the
Premises and it shall be deemed reasonable for Landlord to refuse to consent to
any such alterations. All work approved by Landlord shall be performed by Tenant
or Tenant's contractors in a first-class, diligent and workmanlike manner and so
as not to unreasonably interfere with any owners, tenants or occupants of
adjoining premises or buildings. Tenant shall utilize for such purposes only
licensed contractors and materials reasonably approved in writing by Landlord
(and Landlord hereby approves Vance Brown). Any construction by Tenant shall be
in conformance with the plans and specifications reasonably approved by Landlord
and with any and all

                                      -14-
<PAGE>

applicable rules and regulations of any federal, state, county or municipal
agency or other governmental body having jurisdiction over the Premises
(including, without limitation, the Americans With Disabilities Act and its
state and local counterparts) and with any applicable codes and ordinances
regardless of whether such roles, regulations, codes or ordinances relate to
structural, permanent or non-structural alterations. All alterations of Tenant
shall be done at Tenant's sole cost and expense. Tenant agrees to give Landlord
written notice of the commencement date of any such approved alterations,
improvements, additions or repairs to be made within the Premises at least ten
(10) days prior to the commencement of any such work in order to give Landlord
time to post notices of nonresponsibility. Tenant further agrees to reimburse
Landlord all of Landlord's reasonable costs incurred for review of any plans and
specifications submitted by Tenant for its alterations (other than the initial
Tenant Improvements) and in reviewing the progress of such alterations, but not
to exceed Two-Thousand five Hundred Dollars ($2,500) for each set of
alterations.

     7.4  Liens. Tenant shall keep the Premises free from any liens arising out
          -----
of any work performed, materials furnished or obligations incurred by or for
Tenant. If Tenant fails to keep the Premises free from any such liens and does
not, within twenty (20) days following the imposition of any such lien, cause
the same to be released of record by payment or posting of a proper bond,
Landlord shall have, in addition to all other remedies provided herein and by
law, the right, but not the obligation, to cause such lien to be released by
such means as Landlord shall deem proper, including payment of or defense
against the claim giving rise to such lien. All sums paid by Landlord and all
expenses incurred by it in connection therewith (including attorneys' fees and
costs) shall automatically create an obligation of Tenant to pay an equivalent
amount as Additional Rent, which shall be payable by Tenant on Landlord's demand
with interest as set forth in Section 34.1 below. Such interest charged shall
not constitute Landlord's exclusive remedy nor compromise or limit any other
rights granted Landlord by this Lease or by law or equity. Nothing herein shall
imply any consent by Landlord to subject Landlord's estate to liability under
any mechanic's lien law. Tenant may contest the validity and/or amount of any
lien imposed on the Premises, provided that Tenant has caused such lien to be
released of record by the payment or posting of the proper bond.

                                   ARTICLE 8

                                USE OF PREMISES
                                ---------------

     8.1  Tenant's Use. Tenant shall use and occupy the Premises solely for
          ------------
development, marketing and sale of its Chemdex electronic commerce solutions,
general office purposes, purposes related or incidental thereto, and for no
other use or purpose whatsoever without the prior written consent of Landlord,
which consent may be withheld or conditioned in Landlord's sole discretion.
Tenant covenants and agrees that its electronic commerce solutions business does
not and shall not require Tenant to use or bring onto the Premises, other than
Permitted Materials, any Hazardous Materials, pharmaceuticals, drugs, chemicals
or other materials which are the subject of its electronics commerce solutions
business or otherwise and that Tenant shall not use or bring onto the Premises,
other than Permitted Materials, any Hazardous Materials, pharmaceuticals, drugs,
chemicals or other similar materials (even in di minimus amounts) for any reason
or purpose whatsoever. Tenant shall not use or occupy the Premises in violation
of any law, regulation, code, ordinance or governmental approval or condition
for the Premises, and

                                      -15-
<PAGE>

shall, upon written notice from Landlord, discontinue any use of the Premises
which is not permitted by this Lease. Tenant shall, at Tenant's sole cost and
expense, comply with any directive of any governmental authority which shall, by
reason of the specific nature of Tenant's use or occupancy of the Premises,
impose any duty, condition, order, exaction or other demand upon Tenant or
Landlord with respect to the Premises including, without limitation, any
Environmental Laws, or with respect to the use or occupation thereof. Tenant
shall secure any and all permits and licenses required to conduct its business
in the Premises. Tenant shall not do (or permit any Tenant Party to do) anything
which will invalidate or increase the cost of any insurance policy covering the
Premises and/or property located therein.

     8.2  Nuisance or Waste. Tenant shall not maintain, commit (or permit any
          -----------------
Tenant Party to commit) any nuisance or waste in, on or about the Premises, or
obstruct or interfere in any way with the rights of other tenants or occupants
of the Premises, or injure or annoy them by permitting or making any disturbing
or excessive noise, or by permitting objectionable odors to emanate from the
Premises, or use or allow the Premises to be used by any Tenant Party for any
unlawful purpose. Tenant shall not without Landlord's prior written consent,
place a load upon any floor that exceeds the load per square foot that such
floor is designed to carry or that is then allowed by law.

     8.3  Tenant Sign. Tenant, at Tenant's sole cost and expense, and provided
          -----------
Tenant complies with all applicable laws, statutes, ordinances, codes, rules,
regulations, orders and other lawful requirements of governmental agencies,
shall have the right to install no more than one (1) monument sign at the
Premises. The location(s), type, size, color, content, materials and
illumination of any of Tenant's monument signs shall be subject to Landlord's
prior written approval, which approval shall not be unreasonably withheld or
delayed. Upon the expiration or earlier termination of this Lease, Tenant shall
remove all signs and repair and restore any damage to the Premises caused by
such removal.

     8.4  Parking. At all times during the Term and any Extended Terms, Tenant
          -------
shall be permitted to use, on a non-exclusive basis, the unreserved parking
presently serving the 1010 Joaquin building. Tenant acknowledges and agrees that
all parking for the 1010 Joaquin building is on a shared basis with the three
(3) other immediately contiguous buildings. Tenant acknowledges and agrees that
because of this shared parking arrangement, Tenant's employees, licensees,
invitees, customers and guests may be unable to park in close proximity to the
Premises. Tenant shall satisfy itself in all respects as to the location and
sufficiency of the above-described parking for its intended purposes and use of
the Premises prior to the Commencement Date; provided, however, that Landlord
represents that there are approximately four (4) parking spaces per 1,000
rentable square feet of the Premises.

                                   ARTICLE 9

                              HAZARDOUS MATERIALS
                              -------------------

     9.1  Environmental Disclosures; As-Is. Landlord hereby discloses to Tenant
          --------------------------------
and Tenant hereby acknowledges that Landlord has advised Tenant that (i)
Landlord has previously engaged and continues to engage in pharmaceutical
research in the ground floor of the 1010 Joaquin building and in connection
therewith operates laboratories and uses Hazardous Materials

                                      -16-
<PAGE>

in the ground floor of the 1010 Joaquin building and (ii) that groundwater in
and around the Premises may be contaminated with Hazardous Materials which were
released by parties other than Landlord, including, without limitation,
significant quantities of halogenated volatile organic compounds released into
the groundwater by Teledyne Semiconductor and Spectra-Physics Laser, both of
whom operated facilities located directly upgradient of the Premises. Landlord
has provided Tenant with the groundwater monitoring reports described on
Schedule 2 attached hereto, which Tenant acknowledges receipt of and, except for
- ----------
disclosures to the attorneys, auditors, officers, directors, shareholders,
accountants, investment bankers, lenders, and consultants of Tenant or
disclosures required by law, agrees to keep confidential and not to disclose the
contents thereof (to the extent not a matter of public record) during or
subsequent to the term of this Lease without the prior written consent of
Landlord which Landlord may grant or withhold in its sole discretion. Tenant may
obtain more information about the groundwater in and around the Premises from
publicly available files at the Regional Water Quality Control Board and other
agencies. By entering into this Lease, Tenant acknowledges and agrees (a) that
Tenant has had an opportunity to hire any consultants and make any inquiries
about the environmental condition of the Premises, the 1010 Joaquin building and
the soil and groundwater conditions in and around the Premises that Tenant deems
desirable, (b) that Tenant's representatives and advisors are knowledgeable in
real estate and environmental matters, (c) that Tenant accepts the Premises in
"AS-IS" and "WITH ALL FAULTS" condition and (d) that Tenant is not relying on
any warranty or representation, express or implied, by or on behalf of Landlord
with respect to the Premises including the soil, air and groundwater thereof.
Landlord makes no representations and warranties concerning (x) the
environmental condition of the Premises or the environment in and around the
Premises including the soil, air and groundwater thereof, (y) the presence or
absence of Hazardous Materials in the Premises and the soil, air and groundwater
thereof, or (z) the safety of the Premises for Tenant's employees or the
likelihood that by demolition of portions of the Premises and improving the
Premises pursuant to the Work Letter and occupying and using the Premises,
Tenant's employees will be exposed to Hazardous Materials.

     9.2  Landlord's Indemnity. Except with respect to (i) any soil or
          --------------------
groundwater contamination in and around the Premises existing as of the
Commencement Date and any subsurface mitigation of Hazardous Materials from
other property from and after the Commencement Date and (ii) those matters which
are covered by Tenant's express indemnification and defense obligations set
forth in Section 9.5 below, Landlord shall indemnify, defend and hold Tenant and
its officers, directors, employees, affiliates, subsidiaries, shareholders,
lenders, successors and assigns harmless from and against all claims, damages,
liabilities, losses, fines, penalties, consequential damages, costs and
expenses, demands, causes of action, judgments and attorneys' and consultants'
fees, whether foreseeable or unforeseeable, directly or indirectly, to the
extent arising out of (a) Landlord's or any other Landlord Party's prior,
current or future use, handling, generation, storage, disposal, exposure of
others to, or emission or release of, any Hazardous Materials in connection with
Landlord's use or occupancy of, or pharmaceutical research in, the ground floor
of the 1010 Joaquin building or (b) Landlord's failure to remove any Hazardous
Materials (other than Hazardous Materials contained within building materials
located within the 1010 Joaquin building) to the levels required by applicable
Environmental Laws and government agencies having jurisdiction therefor from
within the 1010 Joaquin building on or before the Commencement Date, which
indemnity shall include, without limitation, the cost of any required or
necessary repair, cleanup

                                      -17-
<PAGE>

or detoxification of the Premises and the preparation of any closure or other
required plans. Neither the acknowledgements or agreements of Tenant in Section
9.1 nor the strict compliance by Landlord with all laws pertaining to Hazardous
Materials shall excuse Landlord from Landlord's obligations of indemnification
pursuant to this Section 9.2. Landlord's obligations pursuant to the foregoing
indemnity shall survive the expiration or earlier termination of this Lease. If
any action or proceeding is brought against Landlord based on the foregoing
Landlord, upon notice from Tenant, shall immediately defend Tenant at Landlord's
expense with counsel reasonably acceptable to Tenant. Landlord shall, at its
sole cost and expense, comply with all laws including all Environmental Laws
applicable to its operations in the ground floor of the 1010 Joaquin building.

     9.3  Compliance with Environmental Laws. Tenant shall, at Tenant's sole
          ----------------------------------
cost and expense, comply with all Environmental Laws applicable to its
operations within the Premises and will at its sole expense obtain, procure and
comply with all permits, licenses and other governmental approvals required for
Tenant's use of the Premises. Tenant shall not permit any Tenant Party to use,
manufacture, handle, treat, transport, produce, dispose of, discharge,
distribute, release, sell, or store any Hazardous Materials (other than
Permitted Materials) in, on or around the Premises during the Term of this
Lease. Notwithstanding the foregoing, Tenant and other Tenant Parties may use,
in compliance with all applicable laws, including Environmental Laws, reasonable
amounts of typical office and janitorial supplies and products typically used in
offices and which are sold over the counter to the public at retail and, during
the construction of the Tenant Improvements or any alterations approved by
Landlord, ordinary and necessary building materials and containerized petroleum
products stored and used in compliance with all laws (collectively, "Permitted
Materials").

     9.4  Investigation and Remediation of Hazardous Materials. Tenant shall
          ----------------------------------------------------
promptly give Landlord copies of any notices, inquiries, claims or documents
received by Tenant from governmental agencies or third parties concerning the
presence of Hazardous Materials in, under and around the Premises, including the
air, soil and groundwater thereof. If, during the Term of this Lease, Tenant, or
Tenant Parties spill, release, discharge, dispose of or introduce Hazardous
Materials to the Premises or if any Hazardous Materials used by Tenant are found
in the soil, atmosphere, surface water or groundwater on, under or about the
Premises due to Tenant's, or Tenant Parties' acts or negligence, Tenant, at
Landlord's option, shall promptly take all actions at its sole cost and expense,
including without limitation, investigation, testing, removal actions,
reporting, cleanup, remediation, and monitoring necessary to return the Premises
and any other affected properties to the condition required by applicable
Environmental Laws, all in accordance with Environmental Laws and the
requirements of all governmental agencies, provided that Landlord's written
approval of such actions shall first be obtained (a "Tenant Cleanup").
Landlord shall not unreasonably withhold or delay such approval. Tenant shall
promptly provide Landlord with the results of any test, investigation or inquiry
conducted by or on behalf of Tenant in connection with the presence or suspected
presence of Hazardous Material contamination on, under or about the Premises,
provided Landlord agrees to keep the same confidential on the same terms as
Tenant pursuant to Section 9.1. With respect to any Tenant Cleanup, Landlord
may, at its election and after consultation with Tenant concerning remediation
costs, control the investigation and clean-up of the contamination and
discussions and negotiations with all governmental authorities, which shall
nevertheless be at Tenant's sole cost and expense.

                                      -18-
<PAGE>

     9.5  Tenant Indemnity. Except with respect to (A) any soil or groundwater
          ----------------
contamination in and around the Premises existing as of the Commencement Date
and any subsurface migration of Hazardous Materials from other property that
contaminates the soil and groundwater in and around the Premises from and after
the Commencement Date and (B) those matters which are covered by Landlord's
express indemnification and defense obligations set forth in Section 9.2 above,
Tenant shall indemnify, defend and hold Landlord and its officers, directors,
employees, affiliates, subsidiaries, shareholders, lenders, successors and
assigns harmless from and against all claims, damages, liabilities, losses,
fines, penalties, consequential damages (including diminution of value of the
Premises and lost rent), costs and expenses, demands, causes of action,
judgments and attorneys' and consultant's fees, whether foreseeable or
unforeseeable, directly or indirectly arising out of (i) the release or
discharge during the Term or any Extended Term hereof of any Hazardous Materials
contained in the building materials located in the 1010 Joaquin building
provided such release or discharge is the result of Tenant's construction of its
initial Tenant Improvements within the Premises and any subsequent alterations,
additions or improvements made by or for Tenant (which claims include, but are
not limited to, employee exposure and toxic tort claims) and (ii) Tenant's and
Tenant Parties' use, handling, generation, storage, disposal, exposure of others
to, emission or release of Hazardous Materials on or about the Premises during
the Term or any Extended Term or a breach of Tenant's obligations under this
Article 9. The foregoing indemnity obligations shall include, without
limitation, the cost of any required or necessary repair, cleanup or
detoxification of the Premises or other properties and the preparation of any
closure or other required plans, whether such action is required or necessary
prior to or following the termination of this Lease. Neither the written consent
by Landlord to the use, generation, storage or disposal of Hazardous Materials
nor the strict compliance by Tenant with all laws pertaining to Hazardous
Materials shall excuse Tenant from Tenant's obligations of indemnification
pursuant to this Section 9.5. Tenant's obligations pursuant to the foregoing
indemnity shall survive the expiration or earlier termination of this Lease. If
any action or proceeding is brought against Landlord based on the foregoing,
Tenant, upon notice from Landlord, shall immediately defend Landlord at Tenant's
expense with counsel reasonably acceptable to Landlord. Except for Landlord's
covenants, agreements and obligations expressly set forth in this Lease, Tenant
hereby waives, releases and relinquishes any and all rights, claims and causes
of action which Tenant may have or may be entitled to assert against Landlord,
whether known or unknown (a) with respect to the environmental condition of the
Premises and the soil, air and groundwater thereof, including, without
limitation, any and all rights, claims and causes of action arising under or
with respect to the California Health and Safety Code, Title 42 of the United
States Code Section 9601 et, seq., the federal and state Occupational Health &
                         -------
Safety Acts, and common law tort theories and/or (b) arising out of the use,
generation, handling, exposure of others to, disposal or release of Hazardous
Materials by Tenant and Tenant Parties on, in, or about the Premises or a breach
of Tenant's obligations under this Section 9.5. With respect to the foregoing
waivers only, Tenant expressly waives the benefits of Civil Code Section 1542
and any similar statute or common law that would render a waiver of unknown
claims unenforceable.

     9.6  Rent Abatement for Hazardous Material Condition. Until such time as
          -----------------------------------------------
any Hazardous Material Condition (not created by Tenant or any Tenant Party),
should it occur, has been remediated in accordance with Environmental Laws such
that the Premises can be safely used and occupied by Tenant for the conduct of
its normal operations at the Premises, the Rent hereunder shall be abated in
proportion to the part of the Premises which is unusable by Tenant

                                      -19-
<PAGE>

for the conduct of its normal operations at the Premises by reason of such
Hazardous Material Condition.

     9.7  Non-Responsibility of Tenant. Notwithstanding anything to the contrary
          ----------------------------
in Sections 9.1 through 9.6 above or elsewhere in this Lease, except to the
extent set forth in Tenant's indemnity in Section 9.5 above, no provision of
this Lease shall obligate Tenant to investigate, monitor, remove, remediate, or
otherwise respond to, or to indemnify, defend or hold harmless Landlord or any
other person as a result of or in connection with, any Hazardous Materials that
(A) were present in any state or form in, on, under or about the Premises on the
Commencement Date or at any time prior thereto, or (B) which may migrate onto or
under the Premises at any time after the Commencement Date, or (C) which are
otherwise not used, handled, stored, generated, produced, manufactured, disposed
of or introduced in, upon or about the Premises by Tenant or a Tenant Party.

     9.8  Survival. The provisions of this Article 9 shall survive the
          --------
expiration or earlier termination of the Lease for any reason.

                                  ARTICLE 10

                            UTILITIES AND SERVICES
                            ----------------------

     10.1 Utilities and Services for the Premises. Subject to the provisions of
          ---------------------------------------
Section 10.3 below and subject to Tenant reimbursing Landlord for utility and
service costs as set forth in Section 10.2 below, Landlord shall cause to be
provided to the Premises the following utilities and services:

          10.1.1  Elevators. Elevator service from the ground floor of the 1010
                  ---------
Joaquin building to the Premises. Subject to Section 10.3 below and reasonable
periodic repair and maintenance work, the elevator shall be available to Tenant
twenty-four (24) hours per day seven (7) days per week.

          10.1.2  HVAC Service. Subject to Section 10.3 below, throughout the
                  ------------
Term and any Extended Term(s), on Mondays through Fridays (excluding federal
holidays) from 8:00 a.m. to 6:00 p.m. (and at other times for an additional
charge to be fixed by Landlord), Landlord shall provide heating, ventilating and
air conditioning ("HVAC") services to the Premises sufficient in Landlord's
reasonable judgment for the comfortable occupancy of the Premises for general
office purposes, subject to any governmental requirements or standards relating
to energy conservation or rationing. Upon Tenant's request and for an additional
charge to be fixed by Landlord, Landlord shall make available at Tenant's sole
cost and expense above-standard and/or after-hours HVAC services; provided,
however, that if at any time during the Term or any Extended Term Landlord, in
Landlord's sole discretion, is providing 24-hour HVAC service to its own
operation on the ground floor of the 1010 Joaquin building, Landlord shall
provide after-hours HVAC service (but not above standard HVAC service) to Tenant
at no additional cost to Tenant. Any minimum time for use of above-standard
and/or after hours HVAC services, any minimum area of the Premises required to
be serviced in order to provide above-standard and/or after hours HVAC services
to the Premises, and the cost thereof shall be determined by Landlord and
confirmed in writing to Tenant as the same may change from time to time. The
expense for such

                                      -20-
<PAGE>

above-standard and/or after-hours HVAC services shall be based on Landlord's
actual cost therefor (plus a reasonable administrative fee), shall be billed to
Tenant monthly as Additional Rent and shall be payable by Tenant within ten (10)
business days of receipt of Landlord's invoice therefor.

          10.1.3  Electrical Service. Subject to Section 10.3 below, throughout
                  ------------------
the Term and any Extended Term(s), Landlord shall make available to the Premises
twenty-four (24) hours per day seven (7) days a week electrical current
equivalent to that currently being provided to the Premises (based on 3,000 amp
panels with 480 volt service) for general office use of the Premises, subject to
any governmental requirements or standards relating to energy conservation or
rationing. Tenant's use of electric current shall not exceed the capacity of the
electrical panels, wiring, conduit and meters of the 1010 Joaquin building and
shall not, in any way, increase the amount of such services required to be
furnished to the Premises over that which is supplied to similar office users in
Mountain View. Tenant further agrees not to connect any apparatus or device with
electrical panels, wires, conduit, pipes or other means by which such services
are supplied for the purpose of using additional or unusual amounts of such
electrical services without the prior written consent of Landlord. Tenant shall
not install or use or permit the installation or use of any computer, electronic
data processing equipment or other electronic equipment not incidental to normal
general office use which interferes in any way with the equipment of Landlord or
any other Tenant or of the 1010 Joaquin building or interferes with the use of
the 1010 Joaquin building by Landlord or any other tenants. No rooftop or other
reception outlets or television or radio antennas for broadcasts or reception
shall be installed or used by Tenant without Landlord's prior written consent,
which consent shall not be unreasonably withheld but may conditioned upon the
use thereof being limited to Tenant's primary business purpose, Tenant complying
with all applicable laws, statutes, rules, regulations and codes relating
thereto, obtaining all required permits therefor and complying with Landlord's
requirements concerning protection of the 1010 Joaquin building's roof,
structural components and all building systems, and repair and restoration
following Tenant's removal of such outlets and antennas.

          10.1.4  Water and Sewer. Subject to Section 10.3 below, water shall be
                  ---------------
furnished to the Premises throughout the Term and any Extended Term(s) by
Landlord twenty-four (24) hours per day seven (7) days a week; provided,
however, that water shall be furnished for drinking, cleaning and lavatory
purposes only and subject to Landlord's right to institute conservation and
rationing measures required by law. Subject to Section 10.3 below, sewer
services shall be furnished throughout the Term and any Extended Term(s) to the
Premises by Landlord twenty-four (24) hours per day seven (7) days a week, and
these services shall be consistent with those supplied by the City of Mountain
View and sufficient for the comfortable occupancy of the Premises.

          10.1.5  Janitorial Services. Subject to Section 10.3 below, throughout
                  -------------------
the Term and any Extended Term(s) Landlord shall provide janitorial services to
the Premises each evening, Monday through Friday (excluding federal and state
holidays) comparable to (but not conditioned upon the provision of) the
janitorial services currently being provided in the ground floor of the 1010
Joaquin building, provided the Premises are used exclusively for general office
purposes and are kept reasonably neat and in order by Tenant. Janitorial
services shall exclude any kitchen within the Premises but shall include the
break room. Any excess refuse disposal

                                     -21-
<PAGE>

charges shall be billed to Tenant monthly as Additional Rent and shall be
payable by Tenant within ten (10) business days of receipt of Landlord's invoice
therefor.

          10.1.6  No Security Services. Landlord shall not provide any security
                  --------------------
services for the Premises, such security services, if desired by Tenant, being
the sole and exclusive responsibility and cost of Tenant. Tenant hereby waives
any and all claims by reason of Landlord not providing such security services.

     10.2 Computation and Payment of Utilities. Tenant shall pay to Landlord,
          ------------------------------------
as Additional Rent, without prior notice or demand, on the first (1st) day of
each month throughout the Term of this Lease and any Extended Term(s), the
monthly amount which is attributable to Tenant's use of the foregoing utilities
and services at the Premises, the cost of which shall be reasonably estimated
and determined by Landlord (based upon factors such as the size of the Premises,
the character of Tenant's business therein (which is general office) and the
intensity of use of such utilities by Tenant and also taking into account
Landlord's more intensive laboratory use of the ground floor of the Joaquin
building) such that Tenant shall pay the portion of such charges reasonably
consistent with Tenant's use of such utilities and services furnished to the
Premises (collectively, the "Utility Expenses"). If Tenant reasonably objects to
Landlord's estimate of Tenant's utility costs, Tenant, at Tenant's sole cost and
expense, may install submeters at the Premises to measure Tenant's utility
usage. Promptly following Landlord's delivery of the Premises to Tenant and
thereafter promptly following the beginning of each calendar year, Landlord
shall give Tenant written notice of Landlord's estimate of monthly Utility
Expenses for the next twelve (12) months and the actual Utility Expenses from
the prior twelve (12) months as set forth below. Such estimate may be
periodically adjusted upward or downward by Landlord based on Landlord's actual
utility costs (plus a reasonable administrative fee).

Promptly following the end of each calendar year or partial calendar year,
Landlord will furnish Tenant a statement (hereinafter referred to as the
"Utility Expense Statement") covering the calendar year or partial calendar year
just expired. The Utility Expense Statement will be certified to be correct by
an officer of Landlord and will contain a detailed breakdown of the Utility
Expenses during the period covered, and the computation of the amount of Utility
Expenses attributed to Tenant. If the Utility Expense Statement or the audit
described below shows that Utility Expenses for the period covered exceed the
total of Tenant's estimated monthly payments made for such period, Tenant will
pay Landlord the deficiency within thirty (30) days after receipt of the Utility
Expense Statement. If Tenant's payments for such period exceed the Utility
Expenses as shown by the Utility Expense Statement or the audit described below,
Landlord will return the overpayment to Tenant within thirty (30) days or, if
requested by Tenant, credit such overpayment against the next payment(s) of Rent
due hereunder.

If Tenant questions a component of the Utility Expenses for a previous year as
shown on the Utility Expense Statement, Landlord will provide Tenant with a copy
of the actual invoices or other documentation reasonably acceptable to Tenant
substantiating the component within thirty (30) days of Tenant's request
therefor. If the information requested by Tenant is not received within the
thirty (30) day period, Tenant will not be required to make further payments of
the disputed Utility Expenses component for such previous year until such
invoices or documentation are received. Tenant will pay the amount of the
disputed item to Landlord within

                                       22
<PAGE>

thirty (30) days after Tenant's receipt of such invoices or documentation
verifying the appropriateness of the charge. Tenant will not be liable for any
Utility Expenses that have not been stated in a Utility Expense Statement
delivered to Tenant within three hundred sixty-five (365) days after the end of
the calendar year or partial calendar year in which the Utility Expenses were
incurred.

Landlord will maintain accurate records of Utility Expenses at Landlord's office
at the address for notices set forth herein at least twenty-four (24) months
after delivery of the Utility Expense Statement to Tenant. Tenant may at its
cost and expense inspect or audit the records during normal business hours upon
reasonable prior notice on up to two (2) occasions per annum at any time during
said twenty-four (24) month period. If Landlord's accountant protests the
conclusions of the audit, Landlord may contest Tenant's determination by giving
Tenant written notice within thirty (30) days following Landlord's receipt of
the audit report. If Landlord's accountant and Tenant's accountant cannot
mutually agree as to the amount of Utility Expenses within thirty (30) days
after Tenant's receipt of Landlord's notice of protest, Landlord's accountant
and Tenant's accountant will jointly choose a third independent certified public
accountant, whose determination will be binding upon the parties hereto. If the
accountants fail to agree upon the third accountant, either party may apply to
the Superior Court of the County for appointment of such third accountant who
must be an experienced person who (together with his firm) has not previously
performed services for either party. The cost of the third accountant will be
borne equally by the parties.

     10.3 Interruptions. Notwithstanding the provisions of this Article 10,
          -------------
Landlord shall not be liable for, and Tenant shall not be entitled to, except as
provided below, any abatement or reduction of Rent or other damages, remedies or
relief of any nature whatsoever by reason of the unavailability of any of the
foregoing utilities or services for the Premises regardless of whether such
failure is caused by accident, breakage, repairs, strikes, lockouts or other
labor disturbance or disputes of any character, governmental regulation or
moratorium or other governmental action; provided, however, that if the
interruption in utilities or services is caused by the negligence or willful
misconduct of Landlord or any Landlord Party and such interruption unreasonably
interferes with the conduct of Tenant's business in the Premises, then Tenant
shall be entitled to equitable rent abatement to the extent the Premises are
unusable by Tenant in the conduct of its normal business therein commencing on
the second (2nd) business day of such interruption and continuing until such
interruption is sufficiently remedied to permit Tenant to recommence its
business operations in the Premises. Any such failure, stoppage or interruption
of any such utilities or services shall not be construed either as an eviction
of Tenant, or relieve Tenant from the obligation to perform any term, covenant
or agreement of this Lease. Landlord and Tenant shall act jointly and in good
faith and exercise their best efforts to have utility service repaired or
restored immediately or as promptly as possible under the circumstances.

                                  ARTICLE 11

                             RULES AND REGULATIONS
                             ---------------------

          Tenant agrees to abide by and to cause all Tenant Parties to abide by
all reasonable and nondiscriminatory Rules and Regulations for the Premises
imposed by Landlord.

                                       23
<PAGE>

Such Rules and Regulations are imposed for the cleanliness, good appearance,
proper maintenance, good order and reasonable use of the Premises.

                                  ARTICLE 12

                          TAXES ON TENANT'S PROPERTY
                          --------------------------

     12.1 Tenant's Property. Tenant shall be solely liable for and shall pay
          -----------------
prior to delinquency, any and all taxes, levies and assessments imposed upon any
personal property, improvements, equipment, furnishings or trade fixtures placed
by Tenant in or about the Premises (including, without limitation, the Remaining
Furniture), as well as all taxes, levies and assessments imposed on Tenant's
initial Tenant Improvements and on any subsequent alterations, additions or
improvements installed by or on behalf of Tenant within or to the Premises.
Wherever possible, Tenant shall cause all of its personal property,
improvements, equipment, furnishings and trade fixtures and all of its
alterations, improvements and additions to the Premises including, without
limitation, Tenant's initial Tenant Improvements, to be assessed and billed
separately from the real property tax bill for the Premises. If any such taxes,
levies and assessments are levied against Landlord or Landlord's property or if
the assessed value of the Premises is increased by the inclusion therein of a
value placed upon such personal property, improvements, equipment, furnishings
or trade fixtures of Tenant or upon Tenant's alterations, improvements or
additions to the Premises, including Tenant's initial Tenant Improvements,
Tenant shall upon demand pay as Additional Rent all such taxes, levies and
assessments so levied against Landlord.

     12.2 License Fees and Business Taxes. Tenant shall pay, prior to
          -------------------------------
delinquency, all license fees and taxes which may be imposed upon the business
of Tenant conducted on the Premises. Landlord shall not be responsible for the
payment of any such license fees or taxes.

                                  ARTICLE 13

                          FIRE OR CASUALTY; ABATEMENT
                          ---------------------------

     13.1 Restoration. If, at any time prior to the last twelve (12) months of
          -----------
the Term, the Premises or any part thereof is damaged or destroyed by fire or
other casualty required to be covered by the "All Risk" Insurance described in
Section 19.4.1 below, the damage and destruction thereto shall be repaired and
the Premises restored by and at the expense of Landlord, but only up to the
amount of available insurance proceeds under the "All Risk" Insurance described
in Section 19.4.1 below (unless no proceeds are available because Landlord
failed to maintain such "All-Risk" Insurance in accordance with this Lease)
provided such repairs can, in Landlord's reasonable opinion, be made within two
hundred seventy (270) days after the occurrence of such damage or destruction
without the payment of overtime or other premiums, and the Lease shall continue
in full force and effect. If such damage or destruction occurs during the last
twelve (12) months of the Term, or is caused by a casualty not required to be
covered by such "All Risk" Insurance, or if, in Landlord's reasonable opinion,
such repairs and restoration cannot be so made within two hundred seventy (270)
days after the occurrence of such damage or destruction, the Lease may be
terminated by Landlord as provided in Section 13.3 below. Additionally, if such
damage or destruction occurs during the last twelve (12) months of the

                                     -24-
<PAGE>

Term or if, in Landlord's reasonable opinion, such repairs cannot be made within
two hundred seventy (270) days after the occurrence of such damage or
destruction, then the Lease may be terminated by Tenant as provided in Section
13.3 below.

     13.2 Rent Abatement. Until Landlord's required repairs and restoration
          --------------
pursuant to Section 13.1 above are completed, the Rent hereunder shall be abated
in proportion to the part of the Premises which is unusable by Tenant for the
conduct of its normal business or operations at the Premises. If the damage or
destruction is due to the negligence or willful misconduct of Tenant or Tenant's
employees, agents, contractors, subcontractors, invitees or licensees, there
shall be no abatement of Rent regardless of the period during which the Premises
is unusable. If this Lease is not terminated by Landlord or Tenant as provided
in Section 13.3 below, Tenant shall be responsible for making all repairs to
and/or replacement or restoration of its initial Tenant Improvements and its
additions, improvements, alterations and trade fixtures made by or for Tenant to
the Premises and all of its furniture, fixtures, equipment and personal
property, including, without limitation, the Remaining Furniture.

     13.3 Special Elections. If repairs for damage and destruction covered by
          -----------------
Section 13.1 cannot, in Landlord's opinion, be made within two hundred seventy
(270) days after the occurrence of the damage or destruction, or if the damage
or destruction is occasioned by an act for which Landlord is not required under
this Lease to be insured, Landlord may, in its sole and absolute discretion,
elect to make such repairs within a reasonable time and in such event, unless
Tenant shall elect to terminate this Lease as provided below, this Lease shall
continue in effect and the Rent shall be abated in the manner provided in
Section 13.2 above. In all events Landlord's election to make such repairs must
be evidenced by written notice delivered to Tenant within sixty (60) days after
the occurrence of the damage or destruction. If Landlord elects not to make such
repairs and so notifies Tenant, then either party may, by ten (10) days' written
notice to the other, cancel this Lease as of the date of the occurrence of such
damage or destruction. In addition, and notwithstanding any desire or election
by Landlord to make repairs or rebuild, Tenant, in its sole discretion, may
elect to terminate this Lease by written notice to Landlord if (i) such damage
or destruction occurs during the last twelve (12) months of the Term, or (ii) if
in Landlord's reasonable opinion, such repairs cannot be completed within two
hundred seventy (270) days after the occurrence of such damage or destruction or
(iii) if Landlord fails to notify Tenant within sixty (60) days following the
date of such damage or destruction of Landlord's intent to repair and restore
the Premises.

     13.4 No Claims. In no event shall Tenant be entitled to any claims,
          ---------
relief, remedies, compensation or damages for loss of use of the whole or any
portion of the Premises and/or for any inconvenience or annoyance occasioned by
any such damage, destruction, repair, reconstruction or restoration, Tenant's
sole remedy being the right to Rent abatement as provided for in Section 13.2
above. Tenant hereby waives any statutory rights of setoff and/or termination
that it may have (including but not limited to those contained in California
Civil Code Sections 1932, 1933(4) and 1942) which may arise by reason of any
partial or total destruction of the Premises.

                                     -25-
<PAGE>

                                  ARTICLE 14

                                EMINENT DOMAIN
                                --------------

     14.1  Total Condemnation. If the whole of the Premises is acquired or
           ------------------
condemned by eminent domain, inversely condemned or sold in lieu of condemnation
for any public or quasi-public use or purpose ("Condemned"), the Term of the
Lease shall terminate as of the date of title vesting in such proceeding and
Rent shall be adjusted as of the date of such termination.

     14.2  Partial Condemnation. If any part (but not all) of the Premises is
           --------------------
Condemned and such partial Condemnation renders the balance of the Premises not
reasonably usable for the normal business or operations of Tenant at the
Premises, as reasonably determined by Landlord and Tenant, then this Lease shall
terminate as of the date of title vesting in such proceeding (or such earlier
date as the Premises are rendered not reasonably usable for the normal business
of Tenant at the Premises) and Rent shall be adjusted to such date. If such
Condemnation is not sufficiently extensive to render the balance of the Premises
not reasonably usable for the normal business of Tenant as reasonably determined
by Landlord and Tenant, then Landlord shall, to the extent of available
Condemnation proceeds from the portion of the Premises Condemned, restore the
Premises to a condition comparable to its condition immediately prior to such
Condemnation less the portion thereof lost in such Condemnation, and this Lease
shall continue in full force and effect and, as of the date of such title
vesting, the Rent shall be equitably reduced as reasonably determined by
Landlord. If any parking areas within the Premises are Condemned to such an
extent that the Premises are not reasonably useable for the normal business of
Tenant as reasonably determined by Landlord and Tenant, then Tenant may elect to
terminate this Lease upon written notice to Landlord. Additionally, (i) if in
the reasonable opinion of Landlord the remaining portion of the Premises not
Condemned cannot reasonably or practicably be repaired or converted so as to
permit substantially the same use for which the Premises was used immediately
prior to the Condemnation, Landlord shall have the right to terminate this Lease
by giving the Tenant at least sixty (60) days' written notice of such
termination, and (ii) if the Condemnation has a material adverse effect upon the
means of access to the Premises or twenty-five percent (25%) or more of the
Premises will be taken through Condemnation, then Tenant shall have the right to
terminate this Lease by giving Landlord at least sixty (60) days' notice
thereof.

     14.3  Landlord's Award. Subject to Section 14.4 below, if the Premises are
           ----------------
wholly or partially Condemned, Landlord shall be entitled to the entire award
paid for such Condemnation, and Tenant waives any right or claim to any part
thereof from Landlord or the condemning authority. No award for any partial or
entire taking shall be apportioned, and subject to Section 14.4 below, Tenant
hereby assigns to Landlord any award which may be made in such taking or
Condemnation.

     14.4  Tenant's Award. Tenant shall have the right to claim and recover from
           --------------
the Condemning authority, but not from Landlord, solely such compensation as may
be awarded or recoverable by Tenant in Tenant's own right for (a) the taking of
the unamortized or undepreciated value of any leasehold improvements owned by
Tenant that Tenant has the right to remove at termination of this Lease and that
Tenant elects not to remove, (b) reasonable removal and relocation costs for any
leasehold improvements that Tenant has the right to the remove and

                                      -26-
<PAGE>

elects to remove (if the Condemning authority approves of the removal), (c) loss
of goodwill, (d) relocation costs under Government Code Section 7262 (the claim
for which Tenant may pursue by separate action independent of this Lease), and
(e) any other amount in addition to the foregoing that does not in any manner or
to any extent reduce the amount of the award payable to Landlord. Tenant shall
have the right to negotiate directly with the Condemning authority for the
foregoing compensation.

     14.5  Temporary Condemnation. If the whole or any part of the Premises
           ----------------------
shall be Condemned for any temporary public or quasi-public use or purpose, this
Lease shall remain in effect and Tenant shall be entitled to receive for itself
such portion or portions of any award made for such use with respect to the
period of the Condemnation which is within the Term. If a temporary Condemnation
remains in force at the expiration or earlier termination of the Term, Tenant
shall pay to Landlord a sum equal to the reasonable cost of performing any
obligations required of Tenant by this Lease with respect to the surrender of
the Premises, including without limitation, repairs and maintenance, and upon
such payment Tenant shall be excused from any such obligations. If a temporary
Condemnation is for an established period which extends beyond the Term, the
Lease shall terminate as of the date of occupancy by the Condemning authority,
and the awards shall be as provided in Sections 14.3 and 14.4.

     14.6  Notice and Execution. Landlord shall, within five (5) business days
           --------------------
of service of process in connection with any Condemnation or potential
Condemnation, give Tenant notice in writing thereof. Tenant shall promptly
execute and deliver to Landlord all instruments that may be reasonably required
to effectuate the provisions of this Article 14. Landlord may, without any
obligation or liability to Tenant, stipulate with any condemning authority for a
judgment of Condemnation without the necessity of a formal suit or judgment of
Condemnation, but only so long as Tenant's right to receive compensation or
damages in a separate proceeding for its trade fixtures, personal property and
relocation expenses is not negated or diminished thereby by this Section. Tenant
hereby waives any statutory rights of termination that it may have arising by
reason of the condemnation, including those contained in Section 1265.130 of the
California Code of Civil Procedure.

                                  ARTICLE 15

                           ASSIGNMENT AND SUBLETTING
                           -------------------------

     15.1  General Prohibition. Tenant shall not, either voluntarily,
           -------------------
involuntarily or by operation of law, directly or indirectly, sell, hypothecate,
assign, encumber, mortgage, dispose of or otherwise transfer this Lease (or any
portion thereof), or any of Tenant's beneficial interest therein, or sublet the
Premises or any part thereof, or permit the same to be occupied by anyone other
than Tenant without the prior written consent of Landlord and any attempt to do
so without such prior written consent shall be null and void and shall
constitute an Event of Default hereunder. Subject to the provisions of this
Section 15.1 and Sections 15.2 and 15.3 below, Landlord agrees not to
unreasonably withhold its consent to any proposed assignment or sublease of this
Lease, provided that the proposed assignee or subtenant (i) is reasonably
satisfactory to Landlord as to its creditworthiness, character and business
reputation, (ii) will occupy the Premises solely for the uses permitted under
this Lease and (iii) in the case of an assignment, assumes and agrees to be
bound and directly responsible for all of Tenant's

                                      -27-
<PAGE>

obligations hereunder. Landlord's consent to any such assignment or sublease
shall in no event be construed as releasing Tenant from any or all of its
duties, liabilities or obligations under this Lease, including, without
limitation, the obligation to pay Rent and all other sums due under this Lease,
nor as relieving Tenant from the requirement of obtaining Landlord's prior
written consent to any further assignment or subletting. Notwithstanding any
contrary provisions of this Article 15 or any contrary provisions of Article 15
of the Plymouth Lease, (a) during the Term and any Extended Term(s), Tenant may
sublease up to, but not more than, an aggregate of Twenty Thousand (20,000)
rentable square feet of space within the Premises and/or the Plymouth Premises
(which 20,000 rental square feet may, at Tenant's option, include only up to,
but not more than, Twelve Thousand (12,000) rentable square feet in the
aggregate in the Premises), upon prior written notice to Landlord but without
Landlord's consent, to one (1) or more Tenant Subsidiaries (as defined in
Section 1.17 above) and (b) Tenant may assign this Lease or sublease all or a
portion of the Premises, upon prior written notice to Landlord but without
Landlord's consent, to a Tenant Affiliate (as defined in Section 1.16 above)
(with the foregoing transactions being referred to in this Article 15 as
"Internal Transaction.") Any assignment or sublease to a Tenant Affiliate or a
Tenant Subsidiary in any Internal Transaction shall not release or relieve
Tenant of any of its duties, liabilities or obligations under this Lease
including, without limitation, the obligation to pay Rent and all other charges
under this Lease and (x) with respect to an assignment, such Tenant Affiliate
shall assume, in full, all of the obligations of Tenant under this Lease
pursuant to assumption documentation reasonably acceptable to Landlord and (y)
with respect to a sublease, such Tenant Affiliate or Tenant Subsidiary and the
proposed sublease shall comply with all of the provisions of Section 15.7 set
forth below.

     15.2  Lease Termination. If at any time during the Term or any Extended
           -----------------
Term(s) of the Lease, Tenant determines that it wishes to assign or sublease all
or any portion of the Premises to any person or entity prior to marketing such
space to a proposed assignee or subtenant, Tenant shall first deliver a written
notice of the foregoing to Landlord. Landlord shall have the right, in
Landlord's sole and absolute discretion, to be exercised within fifteen (15)
business days following Landlord's receipt of Tenant's written notice, to either
(i) subject to the provisions of this Article 15, permit Tenant to proceed with
its plans to assign this Lease or sublet the portion of the Premises which was
the subject of Tenant's written notice or (ii) (A) in the case of a proposed
assignment or sublease of more than fifty percent (50%) of the total rentable
square footage of the Premises, terminate this Lease as to the entire Premises
and release Tenant from its remaining obligations hereunder (other than Tenant's
obligations hereunder which expressly survive the termination of the Lease), or
(B) in the case of the proposed assignment or sublease of less than fifty
percent (50%) of the Premises, terminate the Lease with respect to the portion
of the Premises that Tenant wishes to sublease and amend the Lease to reflect
the reduction in the rentable square footage of the remaining Premises; provided
that the foregoing termination rights shall not apply to an Internal Transaction
(as defined in Section 15.1 above) (but shall apply to the subleasing of any
space in the Premises and the Plymouth Premises in excess of 20,000 rentable
square feet in the aggregate to Tenant Subsidiaries); and provided further, that
Tenant shall have the right, subject to Landlord's right (a) to reasonably
consent to the proposed subtenant pursuant to Sections 15.1 above and 15.3
below, (b) to receive reimbursement of Landlord's costs pursuant to Section 15.6
below and (c) to approve the form of sublease agreement pursuant to Section 15.7
below, to enter into a sublease (and/or a succeeding replacement sublease of the
same space) of up to, but not more than, an aggregate of Ten

                                      -28-
<PAGE>

Thousand (10,000) rentable square feet of space within the Premises and/or the
Plymouth Premises for a term not to exceed twenty-four (24) months without
giving Landlord the right to terminate the Lease as to such subleased portion of
the Premises. If Landlord elects not to recapture the Premises or portion
thereof which was the subject of Tenant's written notice or fails to respond in
writing to Tenant within such fifteen (15) business day period, then for a
period of six (6) months thereafter, subject to the provisions of this Article
15, Tenant may proceed with its plans to attempt to assign or sublease the
portion of the Premises which was the subject of Tenant's written notice.

     15.3  Assignment Information. Provided Tenant has first complied with the
           ----------------------
provisions of Section 15.2 above, if Tenant desires at any time to assign this
Lease or to sublet the Premises or any portion thereof (other than to a Tenant
Affiliate), Tenant shall first notify Landlord of its desire to do so and shall
submit in writing to Landlord (i) the name of the proposed subtenant or assignee
(including a Tenant Subsidiary); (ii) the nature of the proposed subtenant's or
assignee's business to be carried on in the Premises (including a Tenant
Subsidiary); (iii) the terms and conditions of the proposed sublease or
assignment (including complete and accurate copies of all proposed assignment or
sublease documentation) including a sublease to a Tenant Subsidiary; (iv) such
financial and business information as Landlord may reasonably request concerning
the proposed subtenant or assignee (other than a Tenant Subsidiary) including
information concerning the proposed subtenant's or assignee's use, handling,
storage and disposal of Hazardous Materials; and (v) such other information as
Landlord may reasonably request. If Tenant claims that any assignment or
subleasing constitutes an Internal Transaction, Tenant shall provide to Landlord
all information required to substantiate such assignment or subleasing as a bona
fide Internal Transaction. Landlord shall grant or withhold its consent to any
proposed assignment or subletting within ten (10) business days from the date of
receiving full and complete copies of all of the information, materials and
documents set forth in this Section 15.3.

     15.4  Rent Increase. The Monthly Base Rent for the portion of the Premises
           -------------
assigned or sublet (the "Applicable Portion") shall be increased to the Monthly
Base Rent for such Applicable Portion prior to such assignment or subletting
plus one hundred percent (100%) of the amount by which any rental payment or
other consideration of any nature whatsoever received by Tenant from the
assignee or subtenant including any Tenant Affiliate or Tenant Subsidiary
(whether received before or after the effective date of such approved assignment
or subleasing) for such Applicable Portion exceeds the Monthly Base Rent paid by
the Tenant to Landlord for such Applicable Portion; provided, however, Tenant
may offset against the increase in Monthly Base Rent hereunder solely (a)
Tenant's actual and reasonable third party brokerage fees and marketing costs
incurred in such assignment or sublease transaction, (b) Tenant's actual and
reasonable attorneys' fees incurred in such assignment or sublease transaction,
and (c) and the costs of reasonable alterations to the Applicable Portion
actually installed or paid for by Tenant in connection with the occupancy of the
Applicable Portion by such assignee or subtenant (amortized over the useful life
of such alternations with interest thereon at Eight Percent (8%) per annum). For
purposes of this Section 15.4, the term "rental payment" shall mean all
consideration paid or given, directly or indirectly, to Tenant for the use of
the Premises or any portion thereof and the term "consideration" shall mean and
include money, services, property or any other thing of value such as warrants,
stock or securities, payment of costs, cancellation of indebtedness, discounts,
rebates and the like and including, without limitation, key money and

                                      -29-
<PAGE>

bonus money given to Tenant for the use of the Premises or any portion thereof,
whether paid to Tenant before or after the effective date of the assignment or
sublease. Notwithstanding the foregoing, under no circumstances shall Landlord
be entitled to (a) any security deposits or other sums given to Tenant as
security for the assignee's or subtenant's obligations or (b) any portion of any
bona fide consideration paid for any assets of Tenant (other than Tenant's
leasehold interest hereunder and separate and apart from any consideration paid
for the assignment and subleasing) in connection with the sale or other transfer
of such assets by Tenant. "Sublet" and "sublease" shall include a sublease as to
which Tenant is sublessor and any sub-sublease or other subsubtenancy,
irrespective of the number of tenancies and tenancy levels between the ultimate
occupant and Landlord, as to which Tenant receives any consideration, as defined
herein, and Tenant shall require on any sublease which it executes that Tenant
receive the profit from all subsubtenancies, irrespective of the number of
levels thereof. Any rental payment or other consideration which is to be passed
through to Landlord by Tenant shall be paid to Landlord within five (5) days
following receipt by Tenant and shall be paid in cash, irrespective of the form
in which received by Tenant from a subtenant or assignee. Tenant acknowledges
and agrees that the purpose of this Section 15.4 is to ensure that Landlord
receives one hundred percent (100%) of any profit (after subtracting Tenant's
costs and fees described in clauses (a) through (c) hereinabove) from any
assignment or sublease of the Premises (including, without limitation, from
Internal Transactions) that Tenant receives over Monthly Base Rent payable by
Tenant hereunder.

     15.5  Stock Transfers. If Tenant is a corporation the stock of which is not
           ---------------
traded on the NYSE, AMEX or NASDAQ exchanges, or if Tenant is a partnership,
limited liability company or unincorporated association, the sale, transfer,
assignment, pledge or hypothecation, other than in connection with any IPO, of
any stock, interest, membership rights or similar interest in such corporation,
partnership, limited liability company or association (as the case may be) in
the aggregate in excess of twenty-five percent (25%) of any class or type of
stock of Tenant or interest in Tenant shall be deemed an assignment within the
meaning of this Article 15 and the corporation, partnership, limited liability
company or association as it exists after such sale, transfer, assignment,
pledge or hypothecation shall be deemed to be a successor and assign of the
Tenant.

     15.6  Costs. In the event that Tenant shall submit a written notice to
           -----
Landlord under Section 15.2 above or assign or sublet the Premises or request
the consent of Landlord to any assignment or subletting, Tenant shall pay
Landlord's reasonable costs and expenses incurred in connection with each such
transaction (including any Internal Transaction), including reasonable
attorneys, architects, engineers or other consultants fees, within ten (10)
business days following written demand therefor from Landlord accompanied by
invoices reasonably substantiating such costs, whether Landlord terminates this
Lease (or any portion thereof), consents to such assignment or subletting or
withholds its consent thereto.

     15.7  Subletting Terms. The following terms and conditions shall apply to
           ----------------
any subletting by Tenant of all or any part of the Premises (including, without
limitation, any subleasing to any Tenant Affiliate or Tenant Subsidiary) and
shall be deemed included in all subleases whether or not expressly incorporated
therein:

                                      -30-
<PAGE>

          15.7.1  Tenant assigns and transfers to Landlord all of Tenant's
interest in all rentals and income arising from any sublease of the Premises
heretofore or hereafter made by Tenant, and Landlord may collect such rent and
income and apply the same toward Tenant's obligations under this Lease;
provided, however, that until a default (following the expiration of any
applicable grace or cure periods without cure) shall occur in the performance of
Tenant's obligations hereunder, Tenant may receive and collect the rents
accruing under such sublease. Landlord shall not, by reason of this or any other
assignment of such sublease to Landlord or by reason of the collection of rents
from a subtenant, be deemed liable to the subtenant for any failure of Tenant to
perform and comply with any of Tenant's obligations to such subtenant. Tenant
hereby irrevocably authorizes and directs any such subtenant, upon receipt of a
written notice from Landlord stating that a default (following the expiration of
any applicable cure grace period without cure) exists in the performance of
Tenant's obligations under this Lease, to pay to Landlord the rents and all
other sums due and to become due under the sublease until such default has been
cured by Tenant. Tenant agrees that such subtenant shall have the right to rely
upon any such statement and request from Landlord, and that such subtenant shall
pay such rents or other sums to Landlord without any obligation or right to
inquire as to whether such default exists and notwithstanding any notice, demand
or claim from Tenant to the contrary. Tenant shall have no right or claim
against said subtenant or Landlord for any such rents or sums so paid by
subtenant to Landlord.

          15.7.2  No such sublease of the Premises entered into by Tenant shall
be effective unless and until it has been approved in writing by Landlord. An
approved sublease shall not be changed, supplemented or modified, in any manner,
without Landlord's reasonable prior written consent. Any subtenant shall, by
virtue of entering into a sublease under this Lease, be deemed, for the benefit
of Landlord, to have assumed and agreed to perform and comply with each and
every obligation herein to be performed by Tenant with respect to the subleased
space other than such obligations as are contrary to or inconsistent with
provisions contained in a sublease to which Landlord has expressly consented in
writing.

          15.7.3  In the event Tenant shall default (following the expiration of
any applicable cure period without cure) in the performance of any of its
obligations under this Lease, Landlord, at its option and without any obligation
to do so, may require any subtenant to attorn to Landlord, in which event
Landlord shall undertake the obligations of Tenant under such sublease from the
time of the exercise of said option to the termination of such sublease;
provided, however, Landlord shall not be liable for any prepaid rents or
security deposit paid by such subtenant to Tenant or for any prior default of
Tenant under such sublease.

                                  ARTICLE 16

                          ACCESS AND RESERVED RIGHTS
                          --------------------------

     16.1 Access Rights. Landlord and its agents, representatives and
          -------------
contractors shall at all reasonable times have the right, but not the
obligation, to enter the Premises to (i) inspect the same; (ii) to show the
Premises to prospective purchasers or tenants (as to prospective tenants, only
during the last twelve (12) months of the Term or Extended Term); (iii) to post
notices of nonresponsibility; and (iv) to alter, improve, maintain or repair the
Premises or any other portion thereof, to test and/or monitor groundwater or
investigate the environmental conditions of the

                                      -31-
<PAGE>

Premises on an ongoing basis as determined by Landlord in its sole discretion
and to install, maintain, repair, replace and relocate pipes, ducts, conduits,
wires, meters and other equipment within the demising walls, floors, bearing
columns, roofs and ceilings of the Premises, and in the course of such work to
close entrances, doors, corridors, elevators or other Building facilities or
temporarily abate their operation, all without being deemed an eviction or
constructive eviction of Tenant and without abatement of Rent (other than as
expressly provided below), and Landlord may for such purposes erect scaffolding
and other necessary structures where reasonably required by the character of the
work to be performed, provided that Landlord, in connection with each and all of
the foregoing, shall use all reasonable efforts to ensure that the business of
Tenant shall be interfered with as little as is reasonably practicable. If the
negligence or willful misconduct of Landlord or any Landlord Party in carrying
out any action pursuant to this Section 16.1 unreasonably interferes with the
conduct of Tenant's business in the Premises, then Tenant shall be entitled to
equitable rent abatement to the extent the Premises are unusable by Tenant in
the conduct of its normal business therein commencing on the second (2nd)
business day of such interference and continuing until such interference is
sufficiently remedied to permit Tenant to recommence its normal business
operations in the Premises. Additionally, and as provided in Section 7.2 above,
Landlord shall have sole and exclusive use of and unrestricted access through
the Premises at all times without prior notice to Tenant to the Switch Room (as
defined in Section 7.2 above) during the Term and any Extended Term(s). Tenant
hereby waives any claim for damages for any injury or inconvenience to or
interference with Tenant's business or loss of quiet enjoyment of the Premises
caused by Landlord's entry on the Premises in accordance with this Section 16.2
(but not for injury or damage to persons or Tenant's property in the Premises
caused by Landlord's negligence or willful misconduct). For each of the
aforesaid purposes, Landlord shall at all times have and retain a key, pass code
for security devices or other device and be provided with any required
information with which to unlock all of the doors in, upon and about the
Premises and gain access to the Premises, excluding Tenant's vaults, safes,
files, security cabinets, and other areas designated as secure by Tenant, the
location and/or installation of which have been previously approved by Landlord.
Landlord shall have the right to use any and all means which Landlord may deem
proper to open said doors in an emergency in order to obtain entry to the
Premises, and any entry to the Premises obtained by Landlord by any of said
means shall not under any circumstances be construed or deemed to be a forcible
or unlawful entry into, or a detainer of, the Premises, or any eviction of
Tenant from the Premises or any portion thereof. No provision of this Lease
shall be construed as obligating Landlord to perform any repairs, alterations or
decoration except as otherwise expressly provided in this Lease. Notwithstanding
anything to the contrary in this Section 16.1 or elsewhere in this Lease,
Landlord and Landlord's agents, representatives and contractors, except in the
case of emergency and except for access to the Switch Room (where no notice is
required), shall provide Tenant with at least one business day notice prior to
each entry of the Premises (except, however, in the case where Landlord's
proposed entry is for the purpose of performing non-emergency work in the
Premises, Landlord shall provide Tenant with at least two (2) business days
prior written notice). If the purpose of such access is to perform any work in
the Premises, said notice from Landlord shall include a description of the
proposed work, the location of the proposed work the approximate duration of the
proposed work, and the names of the persons to perform the proposed work. Any
such entry by Landlord or Landlord's agents, representatives and contractors,
shall comply with all reasonable security measures of Tenant (including, without

                                      -32-
<PAGE>

limitation, written sign-in, badging, and accompaniment by a representative of
Tenant) and shall not impair Tenant's operations more than reasonably necessary.

     16.2  Reserved Rights. Landlord further reserves the right from time to
           ---------------
time to change the boundary lines of the lot on which the Premises stands, to
record parcel maps and subdivision maps, and to make other reasonable changes
and to grant other reasonable rights to the exterior portions of the Premises,
including, without limitation, the granting of easements, servitudes, rights of
way and rights of ingress and egress and similar rights to users of adjacent
parcels, utility companies, governmental agencies or other tenants, provided the
same do not interfere with the use, occupancy or quiet enjoyment of the Premises
by Tenant or diminish any of Tenant's rights or increase its obligations under
this Lease. Without limiting the scope of or the generality of foregoing
restrictions on Landlord's rights under this Section 16.2, under no
circumstances may Landlord grant rights which would reduce the parking available
to Tenant hereunder unless Landlord is required to do so under the Parking
Agreement affecting parking for the 1010 Joaquin building.

                                  ARTICLE 17

                         SUBORDINATION AND ATTORNMENT
                         ----------------------------

     17.1  Subordination. This Lease is junior, subject and subordinate to all
           -------------
existing mortgages, deeds of trust, security assignments, covenants, conditions
and requirements and other security instruments of any kind now encumbering the
Premises or any portion thereof including any renewals, amendments,
modifications, replacements or extensions of the same. Landlord reserves the
right to place new liens and other new encumbrances on the Premises or any part
thereof or interest therein superior in lien and effect to this Lease subject to
Tenant's receipt of commercially reasonable non-disturbance protection in a form
similar to that attached to this Lease as Exhibit E with such changes as may be
                                          ---------
reasonably requested by Landlord's lender or the other party to the agreement
(the "Nondisturbance Agreement"). Provided Tenant concurrently or earlier
receives an executed Nondisturbance Agreement from the lienholder or
encumbrance, Tenant agrees to execute, acknowledge and deliver within ten (10)
business days following written demand from Landlord such further instruments
evidencing the subordination of this Lease to any new liens or encumbrances as
may be reasonably requested by Landlord. Notwithstanding such subordination,
Tenant's right to peaceful and quiet possession of the Premises shall not be
disturbed by the foreclosure or termination of future liens or encumbrances so
long as Tenant shall pay the Rent and observe and perform all of the provisions
of this Lease to be observed and performed by Tenant, unless this Lease is
terminated pursuant to specific provisions relating to termination contained
herein. In the event of the foreclosure or termination of any such lien or
encumbrance, or the transfer of title to the Premises, Tenant shall attorn to
the then owner who owns or acquires title to the Premises and shall recognize
such owner as Landlord under this Lease. Tenant agrees to execute and deliver
within ten (10) business days following written demand from such owner any
instruments reasonably required to evidence this attornment.

     17.2  Estoppel Certificates. Tenant shall at any time and from time to time
           ---------------------
upon not less than ten (10) business days' prior written notice by Landlord,
execute, acknowledge and deliver to Landlord a statement in writing certifying
that this Lease is unmodified and in full

                                      -33-
<PAGE>

force and effect (or if there have been modifications, that the same are in full
force and effect as modified and stating the modifications), the dates to which
the Monthly Base Rent and other charges have been paid in advance, if any, and
the amount of the undrawn portion of the Letter of Credit, and stating whether
or not to the actual knowledge of Tenant, Landlord or Tenant is in default in
the performance of any covenant, agreement or condition contained in this Lease
and, if so, specifying each such default of which Tenant may have actual
knowledge, and stating such other matters of which Tenant may have actual
knowledge concerning the status of this Lease as Landlord may reasonably
request. Tenant acknowledges that any such statement delivered pursuant to this
Section may be relied upon by any prospective purchaser of the Premises or any
mortgagee, ground lessor or other like encumbrance thereof or any assignee of
any such encumbrance upon the Premises. Tenant's failure to deliver such
statement within such time shall constitute a default by Tenant under this Lease
and additionally shall be binding and conclusive upon Tenant (i) that this Lease
is in full force and effect, without modification except as may be represented
by Landlord, (ii) that there are no uncured defaults in Landlord's performance
or rights of offset against Tenant's obligations hereunder, and (iii) that not
more than one month's rent has been paid in advance.

                                  ARTICLE 18

                     TRANSFER OF PREMISES; QUIET ENJOYMENT
                     -------------------------------------

           Any sale, transfer, conveyance or other disposition by Landlord of
Landlord's fee interest in the Premises shall operate to release Landlord from
any and all liabilities, obligations and duties under this Lease accruing from
and after the date fee title to the Premises is conveyed of record to the
transferee. Subject to the provisions of Article 17 hereof, Tenant's right to
peaceful and quiet possession of the Premises shall not be disturbed so long as
Tenant shall pay all Rent and observe and perform all of the provisions of this
Lease to be observed and performed by Tenant, unless this Lease is terminated
pursuant to specific provisions contained herein allowing for such termination.

                                   ARTICLE 19

            NONLIABILITY AND INDEMNIFICATION OF LANDLORD; INSURANCE
            -------------------------------------------------------

     19.1  Indemnification. Except for Losses (defined below) caused by the
           ---------------
willful misconduct of, violation of law by, breach of this Lease or any
provision hereof by, or the negligence of Landlord or its agents, employees,
contractors, licensees or invitees, Tenant agrees to indemnify, defend and hold
harmless Landlord and its directors, officers, employees, agents, partners,
trustees, parents, subsidiaries, shareholders, affiliates, lenders, successors
and assigns from and against any and all claims, damages, liabilities, losses,
fines, penalties, actions or causes of action, judgments, costs and expenses,
including attorneys' fees, investigation costs and costs of court (if any)
(collectively, "Losses"), whether foreseeable or unforeseeable, directly or
indirectly arising out of or relating to, in whole or in part, Tenant's or
Tenant Parties use of the Premises or the conduct of Tenant's business at the
Premises or from any activity, work, or thing done, permitted or suffered by
Tenant or Tenant Parties in or about the Premises, and shall further indemnify,
defend and hold harmless such parties from and against any and all such claims
arising from any breach or default in the performance of any obligation on
Tenant's part

                                      -34-
<PAGE>

to be performed under the terms of this Lease, or arising from the negligence of
Tenant or the Tenant Parties during the Term or any Extended Term, and from and
against all costs, attorneys' fees, expenses, damages, judgments, actions and
liabilities incurred in or concerning any such claim or any action or proceeding
brought thereon. If any action or proceeding is brought against Landlord by
reason of any such claim, Tenant, upon notice from Landlord, shall immediately
defend Landlord at Tenant's sole expense by counsel reasonably satisfactory to
Landlord. The indemnity obligations of Tenant shall not be limited by available
insurance proceeds. Tenant's indemnification and defense obligations set forth
in this Section 19.1 shall survive the expiration or earlier termination of the
Lease.

     19.2  Waiver of Claims. Tenant, as a material part of the consideration to
           ----------------
Landlord, hereby assumes all risk of damage to property or injury to persons,
including Tenant Parties in, upon or about the Premises from any cause
whatsoever, excepting Landlord's or its agents', employees', contractors',
licensees' or invitees' willful misconduct, violation of law, breach of this
Lease or any provision hereof, or negligence, and Tenant hereby waives all known
claims in respect thereof against Landlord. Tenant's obligations set forth in
this Section 19.2 shall survive the expiration or earlier termination of the
Lease.

     19.3  Insurance Obligation. Tenant hereby agrees to obtain, maintain and
           --------------------
keep in full force and effect at all times during the Term and any Extended Term
of this Lease, at Tenant's sole cost and expense, for the protection of Tenant
and Landlord, and, if required by Landlord, Landlord's lenders, policies of
insurance issued by a responsible carrier or carriers qualified to do business
in the State of California and maintaining a rating of at least "A VIT" or
better in Best's Insurance Guide and in a form reasonably acceptable to Landlord
which afford the following:

           19.3.1  Worker's Compensation Insurance in compliance with California
law and Employer's Liability Insurance with limits of not less than One Million
Dollars ($1,000,000) per occurrence and aggregate. Tenant on behalf of itself
and all persons and parties claiming under or through Tenant, including, without
limitation, Tenant's insurance carriers, waive all rights of subrogation which
Tenant may have against Landlord under applicable worker's compensation
statutes.

           19.3.2  Commercial General Liability Insurance protecting Landlord
and Tenant against claims for death, bodily injury, personal injury and property
damage based upon, relating to or arising out of Tenant's and Tenant Parties'
leasing, use, occupancy, repair and maintenance of the Premises and all areas
appurtenant thereto or from the conduct of Tenant's business or profession or
anything done, permitted or suffered by Tenant in or about the Premises and all
areas appurtenant thereto. Such Commercial General Liability Insurance shall be
written on an occurrence basis and shall provide for a combined single limit of
not less than Two Million Dollars ($2,000,000) per occurrence per location and
shall include, without limitation, Blanket Contractual Liability, Broad Form
Property Damage, Fire Legal Liability, Personal Injury, Completed
Operations/Products Liability (if applicable), Owned and Non-Owned Automobile
Coverage, (included or in a separate policy, with limits of not less than Two
Million Dollars ($2,000,000) per occurrence and aggregate), Protective and/or
Contingent Liability Insurance, Additional Insured-Managers or Landlords of
Premises Endorsement and an Amendment of the Pollution Exclusion for damage
caused by heat, smoke or fumes or from a hostile fire. The

                                      -35-
<PAGE>

policy shall not contain any intra-insured exclusions as between insured persons
and organizations. The policy shall specifically include coverage for liability
assumed under this Lease as an "insured contract" and shall insure all of
Tenant's indemnity obligations under this Lease including, without limitation,
Tenant's indemnity obligations under Section 19.1 above. The limits of insurance
carried by Tenant as set forth above shall not, however, limit the liability of
Tenant under this Lease or relieve Tenant of any liability under this Lease.

          19.3.3  "All Risk" Insurance, including Fire and Extended Coverage,
Vandalism and Malicious Mischief and Sprinkler Leakage insurance in an amount
equal to the full replacement cost of all of Tenant's initial Tenant
Improvements constructed by or for Tenant pursuant to the Work Letter, all
improvements, additions, alterations and trade fixtures installed within the
Premises by Tenant and all of Tenant's fixtures, furnishings, equipment and
personal property, including, without limitation, all Remaining Furniture, with
a commercially reasonable deductible. The proceeds of the foregoing insurance
shall be used by Tenant solely for the replacement of Tenant's initial Tenant
Improvements and its additions, alterations and trade fixtures installed within
the Premises, and Tenant's fixtures, furnishings, equipment and personal
property, including, without limitation, all Remaining Furniture.

     19.4  Landlord's Insurance Obligations. Subject to Tenant's compliance with
           --------------------------------
Tenant's payment obligations under Article 5 of the Lease with respect to
Landlord's Insurance Premiums, Landlord hereby agrees to obtain, maintain and
keep in full force and effect at all times during the term and any Extended
Term, for the protection of Landlord and, if required by Landlord, Landlord's
lenders, policies of insurance issued by a responsible carrier or carriers
qualified to do business in the State of California and maintaining a rating of
at least "A VII' or better in Best's Insurance Guide which afford the following
coverages:

          19.4.1  "All Risk" Insurance with commercially reasonable deductibles
including, without limitation, Fire and Extended Coverage, a Change in Condition
Endorsement with limits adequate to rebuild the Premises in compliance with then
applicable laws, codes and ordinances, Vandalism and Malicious Mischief,
Sprinkler Leakage insurance, and in Landlord's sole discretion, Flood Insurance
and/or Earthquake Insurance, in the name of and for the benefit of Landlord, and
with all proceeds payable to Landlord (and/or any of Landlord's lenders as
Landlord may direct) in an amount equal to the full replacement cost of the
Premises (as the same may be increased from time to time) including, without
limitation, loss or damage to the Premises, but excluding coverage for Tenant's
initial Tenant Improvements constructed by or for Tenant pursuant to the Work
Letter and excluding coverage for any improvements, alterations, additions,
trade fixtures, equipment, furnishings, fixtures and personal property
(including the Remaining Furniture) installed within the Premises by or for
Tenant. Tenant shall be liable for the payment of any deductible amount in the
event of any loss covered by the insurance required under this Section 19.4.1.

          19.4.2  Commercial General Liability Insurance protecting Landlord
against claims for death, bodily injury, personal injury and property damage
based upon, relating to or arising out of Landlord's leasing of the Premises and
all areas appurtenant thereto or anything done, permitted or suffered by
Landlord in or about the Premises and all areas appurtenant thereto. Such
Comprehensive General Liability Insurance shall be written on an occurrence
basis and shall provide for a combined single limit of not less than Five
Million Dollars

                                      -36-
<PAGE>

($5,000,000) per occurrence per location and shall include, without limitation,
Blanket Contractual Liability, Broad Form Property Damage, Fire Legal Liability,
Personal Injury, Completed Operations/Products Liability, if applicable, Owned
and Non-Owned Automobile Coverage (included or in a separate policy, with limits
of not less than Two Million Dollars ($2,000,000) per occurrence and aggregate),
Protective and/or Contingent Liability Insurance, Additional Insured-Managers or
Landlords of Premises Endorsement and an Amendment of the Pollution Exclusion
for damage caused by heat, smoke or fumes or from a hostile fire. Tenant shall
be named as an additional insured on Landlord's Commercial General Liability
Insurance Policy.

          19.4.3  Business or Rental Interruption Insurance in the name of and
for the benefit of Landlord and with all proceeds payable to Landlord (and/or
any of Landlord's lenders as Landlord may direct), insuring the loss of the Rent
and other charges payable by Tenant to Landlord under this Lease (including all
Monthly Base Rent, Property Taxes, Insurance Premiums, and any scheduled rental
increases for a period not to exceed twelve (12) months). Said insurance shall
contain an agreed valuation provision in lieu of any coinsurance clause, and the
amount of coverage shall be adjusted annually to reflect the projected Rent,
Property Taxes, Insurance Premiums and other expenses, if any, otherwise payable
by Tenant. Tenant shall be liable for any deductible amount in the event of any
loss covered by the insurance required under this Section 19.4.3.

Any insurance required to be carded by Landlord under Sections 19.4.1, 19.4.2 or
19.4.3 above may be carried by Landlord under a blanket insurance policy
coveting the Premises and any of Landlord' s other locations.

     19.5  Policy Terms. All liability insurance required of Tenant under this
           ------------
Article (except Worker's Compensation) shall be primary coverage and shall not
be contributing with any other liability insurance maintained by Landlord.

     19.6  Insurance Certificates. Tenant shall deliver to Landlord at least ten
           ----------------------
(10) business days prior to the time any insurance coverage is first required to
be carded by Tenant, and thereafter at least thirty (30) days prior to
expiration of such policy, certificates of insurance evidencing the required
coverages with limits not less than those specified in Section 19.3 above. The
certificate evidencing the insurance required pursuant to Section 19.3.2 above
shall name Landlord and each of Landlord's lenders (if any), as additional
insureds, and the certificate evidencing the insurance required pursuant to
Section 19.4.2 above shall name Tenant as additional insured. The certificates
to be delivered by Tenant shall expressly provide that not less than thirty (30)
days' prior written notice shall be given to Landlord in the event of
cancellation or non-renewal of the coverages evidenced by such certificates.
Upon written request of Landlord, Tenant shall deliver full and accurate copies
of all insurance policies required of it by this Lease.

     19.7  Disclaimer. Landlord makes no representation that the limits or form
           ----------
of insurance coverage specified to be carded by Tenant under the terms of this
Lease are adequate to protect Tenant against Tenant's undertaking under this
Article 19.

                                      -37-
<PAGE>

                                   ARTICLE 20

                             WAIVER OF SUBROGATION
                             ---------------------

          Notwithstanding anything to the contrary in this Lease, Tenant and
Landlord each hereby, on behalf of itself and all persons and parties claiming
under or through it, including without limitation its insurance carrier(s),
waive any right of recovery or claim against the other for any damage to or
destruction of any property located in or about the Premises which results from
or arises out of any casualty or event insured or required to be insured
hereunder by any casualty and/or property insurance policy carried by such
waiving party, regardless of the cause or origin of such casualty or event,
including without limitation, the negligence of Tenant or Landlord. Any policy
or policies of fire, extended coverage or similar casualty insurance or of
liability insurance that either party obtains in connection with the Premises or
Tenant's personal property therein shall include a clause or endorsement denying
the insurer and waiving any rights of subrogation against the other party to the
extent rights have been waived by the insured prior to the occurrence of injury
or loss.

                                   ARTICLE 21

                                ATTORNEYS' FEES
                                ---------------

          In the event of any legal action or proceeding brought by either party
against the other arising out of this Lease, the prevailing party (by way of
settlement or final judgment) shall be entitled to recover reasonable attorneys'
fees and costs incurred in such action and such amount shall be included in any
judgment rendered in such proceeding. The provisions contained in this Article
21 shall survive the expiration or earlier termination of this Lease.

                                   ARTICLE 22

                                     WAIVER
                                     ------

          No waiver by either party hereto of any provision of this Lease or of
any breach by the other party hereunder shall be deemed to be a waiver of any
other provision hereof, or of any subsequent breach by the other party of the
same or any other provision. Landlord's consent to or approval of any act by
Tenant requiring Landlord's consent or approval shall not be deemed consent to
or approval of any subsequent act of Tenant. No act or thing done by Landlord or
Landlord's agents during the Term of this Lease shall be deemed an acceptance or
a surrender of the Premises, unless done in writing signed by Landlord. The
delivery of the keys to any employee or agent of Landlord shall not operate as a
termination of the Lease or a surrender of the Premises. The acceptance of any
Rent by Landlord following a breach of this Lease by Tenant shall not constitute
a waiver by Landlord of such breach or any other breach unless such waiver is
expressly stated in a writing signed by Landlord.

                                      -38-
<PAGE>

                                   ARTICLE 23

                                    NOTICES
                                    -------

          Any notice, consent, approval, request for consent or approval of or
communication to Landlord or Tenant required or permitted to be given under this
Lease shall be effectively given only if in writing and (i) mailed by United
States Registered or Certified Mail, postage prepaid, return receipt requested,
or (ii) sent by a nationally recognized courier service (e.g., Federal Express)
for next day business delivery, or (iii) personally delivered or served against
receipted copy, or (iv) transmitted via facsimile, in each case addressed to the
recipients at their addresses (or fax numbers in the case of facsimile
transmissions) set forth in Items 3 and 5 of the Basic Lease Provisions. Either
party shall have the right to change the address to which notices shall
thereafter be sent by giving notice to the other party as aforesaid. Notices
given in the aforesaid manner shall be deemed delivered on the date of scheduled
delivery, if sent by courier service, or three (3) days after sending, if sent
by mail, or upon personal delivery or service, if personally delivered or
served, or upon the date of successful facsimile transmission, if sent via
facsimile.

                                   ARTICLE 24

                                   BANKRUPTCY
                                   ----------

          In no event shall this Lease be assigned or assignable by operation of
law and in no event shall this Lease be an asset of Tenant in any receivership,
bankruptcy, insolvency, or reorganization proceeding.

                                   ARTICLE 25

                              DEFAULT AND REMEDIES
                              --------------------

     25.1  Events of Default. The occurrence of any of the following shall
           -----------------
constitute a material default and breach of this Lease by Tenant (each, an
"Event of Default"):

          25.1.1  Nonpayment of Rent. Any failure by Tenant to pay Rent or
                  ------------------
Additional Rent or to make any other payment required to be made by Tenant
hereunder on the due date, where such failure continues for three (3) business
days after written notice from Landlord to Tenant demanding such payment;

          25.1.2  Abandonment. Abandonment of the Premises by Tenant;
                  -----------

          25.1.3  Breach of Other Covenants. Any failure by Tenant to observe
                  -------------------------
and perform any obligation, covenant or provision of this Lease to be observed
or performed by Tenant other than those matters specified in Sections 25.1.1 and
25.1.2 above and 25.1.8, 25.1.9, 25.1.10 or 25.1.11 below, where such failure
continues for thirty (30) days after written notice by Landlord to Tenant. If
the nature of such default is such that it cannot reasonably be cured within
such thirty (30) day period Tenant shall not be deemed to be in default if
Tenant shall within such period commence such cure and thereafter diligently
prosecute the same to completion;

                                      -39-
<PAGE>

          25.1.4  False Statement. Any warranty or representation made by Tenant
                  ---------------
in this Lease proves to be false or misleading in any material respect when
made, including any Financial Statements;

          25.1.5  Insolvency. Tenant or any Guarantor becomes insolvent, as
                  ----------
defined in the Federal Bankruptcy Code, admits in writing its insolvency or its
present or prospective inability to pay its debts as they become due, permits or
suffers a judgment, attachment, execution or judicial seizure to exist against
it which materially adversely affects Tenant's ability to conduct its business
in the ordinary course (unless enforcement thereof is stayed pending appeal)
that is not discharged or dismissed within thirty (30) days, makes an assignment
for the benefit of creditors, or any class thereof, for purposes of effecting a
moratorium upon or extension or composition of its debts, proposed any such
moratorium, extension or composition, or commences or proposes to commence any
bankruptcy, reorganization or insolvency proceeding, or other proceeding under
any federal, state or other law for the relief of debtors;

          25.1.6  Involuntary Bankruptcy. Tenant fails to obtain the dismissal,
                  ----------------------
within sixty (60) days after the commencement thereof, of any bankruptcy,
reorganization or insolvency proceeding, or other proceeding under any law for
the relief of debtors, instituted against Tenant by one or more third parties or
any partner of Tenant, or, in any such proceeding, defaults or files an answer
admitting the material allegations upon which the proceeding was based or
alleges its willingness to have an order for relief entered or its desire to
seek liquidation, reorganization or adjustment of any of its debts;

          25.1.7  Receivership. Any receiver, trustee or custodian is appointed
                  ------------
to take possession of all or any substantial portion of the assets of Tenant, or
of Tenant's interest in this Lease;

          25.1.8  Liens. Tenant fails to cause the release, within twenty (20)
                  -----
days after filing, of any lien arising out of any work performed, materials
furnished, or obligations incurred by or for Tenant, which has been filed
against the Premises;

          25.1.9  Assignment. Tenant attempts a transfer, conveyance, mortgage,
                  ----------
encumbrance, pledge, disposition, assignment, sublease or other act in
contravention of Article 15 hereof and fails to cure the same within two (2)
business days of receipt of written notice from Landlord;

          25.1.10  Insurance. Tenant fails to maintain in full force and effect
                   ---------
the insurance coverages required to be maintained by Tenant under this Lease
following written notice thereof from Landlord to Tenant and Tenant's failure to
cure the same within five (5) business days of receipt of such notice; or

          25.1.11  Default Under Plymouth Lease. The occurrence of an "Event of
                   ----------------------------
Default" (as defined in the Plymouth Lease) under the Plymouth Lease shall
constitute an immediate and noncurable Event of Default under this Lease.

     25.2  Remedies of Landlord. In the event of any such Event of Default by
           --------------------
Tenant, Landlord may at any time thereafter, at Landlord's option and without
limiting the exercise of

                                      -40-
<PAGE>

any other right or remedy which Landlord may have in law or equity by reason of
such default or breach, with or without notice or demand, do any of the
following:

          25.2.1  Regain Possession. Re-enter the Premises and take possession
                  -----------------
of the same and of all equipment, fixtures and personal property of Tenant
therein, expel or remove Tenant and all other parties occupying the Premises,
using such force as may be reasonably necessary to do so, without being liable
to any prosecution for such re-entry or for the use of such force, and without
terminating this Lease, and at any time (and from time to time) relet the
Premises or any part thereof for the account of Tenant for such term and upon
such conditions and at such rental as Landlord may deem proper in its sole
discretion. In such event Landlord may receive and collect the rent from such
reletting and apply it first against any and all expenses and costs incurred by
Landlord hereunder as a result of Landlord having to retake and relet the
Premises (including, without limitation, such expenses as Landlord may have
incurred in recovering possession of the Premises, placing the same in good
order and condition, altering, repairing or redecorating the same for reletting
and all other reasonable expenses, commissions and charges, including attorneys'
fees, which Landlord may have paid or incurred in connection with such
repossession and reletting) and then the balance, if any, shall be applied
against any Rent then due from Tenant to Landlord. Landlord may execute any
lease made pursuant hereto in Landlord's name and the tenant thereunder shall be
under no obligation to see to the application by Landlord of any rent collected
by Landlord, nor shall Tenant have any right to collect any rent thereunder.
Whether or not the Premises are relet, Tenant shall pay Landlord all amounts
required to be paid by Tenant up to the date of Landlord's re-entry and
thereafter Tenant shall pay Landlord, until the end of the Term, the amount of
all rent and other charges required to be paid by Tenant hereunder, less the
proceeds of such reletting during the Term, if any, after payment of Landlord's
expenses as provided above. Such payments by Tenant shall be due at such times
as are provided in this Lease, and Landlord need not wait until the termination
of this Lease to recover them by legal action or otherwise. Landlord shall not
by any re-entry or other act be deemed to have terminated this Lease or the
liability of Tenant for the total Rent due hereunder unless Landlord shall give
Tenant written notice of Landlord's election to terminate this Lease.

          25.2.2  Termination. Give written notice to Tenant of Landlord's
                  -----------
election to terminate this Lease at any time after an Event of Default, re-enter
the Premises and take possession of the same and of all equipment, fixtures and
personal property therein, and expel or remove Tenant and all other parties
occupying the Premises, using such force as may be reasonably necessary to do
so, without being liable to any prosecution for such re-entry or for the use of
such force. In such event Landlord shall thereupon be entitled to recover from
Tenant as damages, all of the following:

               i.  The worth at the time of award of any unpaid Rent which had
been earned at the time of such termination; plus

               ii.  The worth at the time of award of the amount by which the
unpaid Rent which would have been earned after termination until the time of
award exceeds the amount of such rent loss that Tenant proves could have been
reasonably avoided; plus

                                      -41-
<PAGE>

               iii.  The worth at the time of award of the amount by which the
unpaid Rent for the balance of the Term after the time of the award exceeds the
amount of such Rent loss that Tenant proves could have been reasonably avoided;
plus

               iv.  Any other amount necessary to compensate Landlord for all
the detriment proximately caused by Tenant's failure to perform its obligations
under this Lease or which in the ordinary course of things would be likely to
result therefrom, including, but not limited to any costs or expenses incurred
by Landlord in retaking possession of the Premises, including reasonable
attorneys' fees; maintaining or preserving the Premises after such Event of
Default; preparing the Premises for reletting to a new tenant, including repairs
or alterations to the Premises for such reletting; leasing commissions; or any
other costs necessary or appropriate to relet the Premises; plus

               v.  At Landlord's election, such other amounts in addition to or
in lieu of the foregoing as may be permitted from time to time by the laws of
the State of California.

               vi.  As used in subsections (i) and (ii) above, the "worth at the
time of award" is computed by allowing interest at the rate set forth in Article
34 below. As used in subsection (iii) above, the "worth at the time of award" is
computed by discounting such amount at the discount rate of the Federal Reserve
Bank of San Francisco at the time of award plus one percent (1%).

          25.2.3  Tenant's Property. Landlord may at its option permit all of
                  -----------------
Tenant's fixtures, furniture, equipment, improvements, additions, alterations,
and other personal property to remain on the Premises and in that event, and
continuing during the length of said Event of Default, Landlord shall have the
right to take exclusive possession of the same and to use the same, free of
charge, until all Events of Default are cured or, at its option, at any time
during the Term, to require Tenant to forthwith remove the same. In the
alternative, in the event of any entry or taking possession of the Premises as
aforesaid, Landlord shall have the right, but not the obligation, to remove
therefrom all or any part of the personal property located therein and may place
the same in a public warehouse at the expense and risk of the owner or owners
thereof and dispose of the same in accordance with the provisions of California
Civil Code Section 1980 et seq. or any successor statutes thereto.

          25.2.4  Cure of Default. In addition to the foregoing remedies,
                  ---------------
Landlord shall, so long as this Lease is not terminated, have the right to
remedy any Event of Default, to maintain or improve the Premises without
terminating this Lease, to incur reasonable expenses on behalf of Tenant in
seeking a subtenant, or to cause a receiver to be appointed to administer the
Premises and any new or existing subleases, and Tenant shall pay to Landlord as
Additional Rent hereunder all of Landlord's reasonable costs in so doing, with
interest at the maximum lawful rate.

          25.2.5  Cumulative Remedies. No remedy or election hereunder shall be
                  -------------------
deemed exclusive but shall, wherever possible, be cumulative with all other
remedies at law or in equity.

     25.3  Default by Landlord. Landlord shall not be deemed to be in default or
           -------------------
breach in the performance of any obligation required to be performed by Landlord
under this Lease unless

                                      -42-
<PAGE>

and until it has failed to perform such obligation within thirty (30) days after
written notice by Tenant to Landlord specifying that Landlord has failed to
perform such obligation; provided, however that if the nature of Landlord's
obligation is such that more than thirty (30) days are required for its
performance, then Landlord shall not be deemed to be in default or breach if it
shall commence such performance within such thirty (30) day period and
thereafter diligently prosecute the same to completion. Tenant shall have no
right to terminate this Lease, except where Landlord fails to cure a material
breach within the time periods set forth in the immediately preceding sentence.
No default or breach on the part of Landlord that would entitle Tenant under the
terms of this Lease or by law to terminate this Lease shall result in a
termination of this Lease unless (i) Tenant has given written notice of such
default or breach by registered or certified mail to any beneficiary of a deed
of trust or mortgagee of a mortgage covering the Premises whose address shall
have been furnished to Tenant and (ii) Tenant offers such beneficiary or
mortgagee the same opportunity to cure the default or breach as is available to
Landlord under the express terms of this Lease. It is expressly understood and
agreed that any money judgment against Landlord resulting from any default or
other claim arising under this Lease or related thereto shall be satisfied only
out of Landlord's equity interest in the Premises, and no other real, personal
or mixed property of Landlord, wherever situated, shall be subject to levy on
any such judgment obtained against Landlord and if such equity interest in the
Premises is insufficient for the payment of such judgment, Tenant will not
institute any further action, suit, claim or demand, in law or in equity,
against Landlord for the amount of such deficiency. Tenant hereby waives, to the
extent waivable under law, any right to satisfy said money judgment against
Landlord except from Landlord's equity interest in the Premises.

                                  ARTICLE 26

                                   HOLD OVER
                                   ---------

          If Tenant holds over after the expiration or earlier termination of
the Term or any Extended Term of this Lease without the express prior written
consent of Landlord, Tenant shall become a tenant of sufferance only at a rental
rate equal to one hundred fifty percent (150%) of the Monthly Base Rent in
effect just prior to expiration or termination, and otherwise upon the terms,
covenants and conditions herein specified, so far as applicable. Acceptance by
Landlord of any Rent after such expiration or earlier termination shall not
constitute a consent to a holdover hereunder or result in a renewal of the Lease
or any lease. The foregoing provisions of this Article 26 are in addition to and
do not affect Landlord's right of reentry or any other rights of Landlord
hereunder or as otherwise provided by law or equity.

                                   ARTICLE 27

                             CONDITION OF PREMISES
                             ---------------------

          Tenant acknowledges that, except as expressly set forth in this Lease,
neither Landlord nor any agent of Landlord has made any representation or
warranty with respect to the Premises, Landlord' s prior use of the Premises,
the presence of any Hazardous Materials in the Premises, the adequacy or
inadequacy of parking for Tenant's intended office use of the Premises, the
compliance of the Premises with any applicable statutes, laws, ordinances or

                                      -43-
<PAGE>

regulations (including, without limitation, any Environmental Laws), or with
respect to the suitability of any part of the Premises for the conduct of
Tenant's business.

                                   ARTICLE 28

                                QUIET POSSESSION
                                ----------------

          Upon Tenant's paying the Rent reserved hereunder and observing and
performing all of the covenants, conditions and provisions on Tenant's part to
be observed and performed hereunder, Tenant shall have peaceful and quiet
possession of the Premises for the entire Term and any Extended Term(s) hereof,
subject to all of the terms and conditions of this Lease.

                                   ARTICLE 29

                          DAMAGE TO TENANT'S PROPERTY
                          ---------------------------

          Landlord and its agents shall not be liable for any damage to Tenant's
property entrusted to employees of Landlord or its agents, nor for loss or
damage to any property by theft or otherwise. Landlord or its agents shall not
be liable for interference with the light or other incorporeal hereditaments.

                                   ARTICLE 30

                                CONFLICT OF LAWS
                                ----------------

          This Lease shall be governed by and construed pursuant to the laws of
the State of California.

                                   ARTICLE 31

                             SUCCESSORS AND ASSIGNS
                             ----------------------

          Except as otherwise provided in this Lease, all of the covenants,
conditions and provisions of this Lease shall be binding upon and shall inure to
the benefit of the parties hereto and their respective heirs, personal
representatives, successors and assigns. Any options or rights given to the
Tenant in this Lease to extend or renew this Lease shall be personal to the
original Tenant named herein and to any Tenant Affiliate to whom this Lease may
be assigned and may not be transferred to any other successor or assign
(including, without limitation, any Tenant Subsidiary) without the prior written
consent of Landlord.

                                  ARTICLE 32

                                    BROKERS
                                    -------

          Tenant warrants that it has had no dealings with any real estate
broker, leasing agent or finder in connection with this Lease, excepting only
the brokers named in Items 14 and 15 of the Basic Lease Provisions and that it
knows of no other real estate broker, leasing agent or finder other than the
brokers named in Items 14 and 15 of the Basic Lease Provisions who is

                                      -44-
<PAGE>

entitled to a commission in connection with this Lease. Tenant agrees to pay and
to indemnify and hold Landlord harmless from, any cost, expense or liability for
any compensation, commission or charges claimed by any other realtors, brokers,
agents or finders claiming by, through or on behalf of Tenant with respect to
this Lease and/or the negotiation thereof. Landlord warrants that it has had no
dealings with any real estate broker, leasing agent or finder in connection with
this Lease, excepting only the brokers named in Items 14 and 15 of the Basic
Lease Provisions and that it knows of no other real estate broker, leasing agent
or finder other than the brokers named in Items 14 and 15 of the Basic Lease
Provisions who is entitled to a commission in connection with this Lease.
Landlord agrees to pay and to indemnify and hold Tenant harmless from, any cost,
expense or liability for any compensation, commission or charges claimed by any
other realtors, brokers, agents or finders claiming by, through or on behalf of
Landlord with respect to this Lease and/or the negotiation thereof. Landlord
covenants and agrees to pay in accordance with its agreement with the broker
named in Item 14, all real estate commissions due in connection with this Lease
to such broker.

                                   ARTICLE 33

                              NEGOTIATED AGREEMENT
                              --------------------

          Tenant and Landlord have been represented by independent counsel in
entering into this Lease. Each of the parties affirms to the other that it has
consulted and discussed the provisions of this Lease with its counsel and fully
understands the legal effect of each provision. The drafting and negotiation of
this Lease has been participated in by each of the parties. For all purposes,
this Lease shall be deemed to have been drafted jointly by each of the parties
and shall not be construed against any party due to authorship.

                                   ARTICLE 34

                  INTEREST ON TENANTS OBLIGATIONS; LATE CHARGE
                  --------------------------------------------

     34.1  Interest. Any amount due from Tenant to Landlord which is not paid
           --------
within three (3) business days of its due date shall bear interest at the lesser
of (i) twelve percent (12%) per annum or (ii) the maximum rate permitted by law
from the date such payment is due (after the expiration of any applicable cure
period hereunder, if any) until paid, but the payment of such interest shall not
excuse or cure any default or breach by Tenant.

     34.2  Late Charges. Tenant recognizes that late payment of any Rent or any
           ------------
portion thereof will result in administrative expense to Landlord, the extent of
which additional expense is extremely difficult and economically impractical to
ascertain. Tenant therefore agrees that if Rent or any portion thereof, remains
unpaid ten (10) business days after said amount is due and written notice from
Landlord demanding payment, the amount of such unpaid Rent shall be increased by
a late charge to be paid Landlord by Tenant equal to five percent (5%) of the
amount of the delinquent Rent or other payment. The amount of the late charge to
be paid Landlord by Tenant on any unpaid Rent or other unpaid amount shall be
due immediately after the date on which the late charge was initially imposed.
Tenant agrees that such late charge is a reasonable estimate of the loss and
expense to be suffered by Landlord as a result of such late payments by Tenant
and may be charged by Landlord to defray such loss and expense. The

                                      -45-
<PAGE>

provisions of this Section in no way relieve Tenant of the obligation to pay
Rent or other amounts on or before the date on which they are due, nor do the
terms of this Section in any way affect Landlord or its obligations under this
Lease or obligate Landlord to accept less than the full Rent amount due at any
time.

                                   ARTICLE 35

                                      TIME
                                      ----

          Time is of the essence of this Lease and the performance of any and
all of its provisions.

                                   ARTICLE 36

                      DEFINED TERMS AND MARGINAL HEADINGS
                      -----------------------------------

          The words "Landlord" and "Tenant" as used herein shall include the
plural as well as the singular. If more than one person is named as Tenant the
obligations of such persons are joint and several. The captions or marginal
headings to the Articles and Sections of this Lease are not a part of this Lease
and shall have no effect upon the construction or interpretation of any part
hereof.

                                   ARTICLE 37

                                PRIOR AGREEMENTS
                                ----------------

          This Lease and its Exhibits contain all of the agreements of the
parties hereto with respect to any matter covered or mentioned in this Lease,
and no prior agreement, understanding, representation, correspondence
(including, without limitation, that certain letter of intent between the
parties dated June 14, 1999 and that certain Office Lease dated July 30, 1999
covering both the Premises and the Plymouth Premises, which Office Lease the
parties acknowledge and agree shall be null and void and of no further force or
effect upon the execution and delivery of this Lease and the Plymouth Lease by
the parties hereto), or communication pertaining to any such matter or the
Premises shall be effective for any purpose. No provision of this Lease may be
amended, supplemented or modified except by an agreement in writing signed by
the parties hereto or their respective successors in interest. If any provision
of this Lease shall be held invalid, void or unenforceable to any extent, the
remainder of this Lease shall not be affected thereby and each provision of this
Lease shall be valid and enforceable to the fullest extent permitted by law.

                                   ARTICLE 38

                              AUTHORITY OF PARTIES
                              --------------------

          Tenant does hereby covenant, represent and warrant that (i) Tenant is
a duly authorized and existing corporation; (ii) Tenant is qualified to do
business in the State of California and is in good standing in the jurisdiction
of its formation; (iii) Tenant has full right and authority to enter into this
Lease; (iv) each person signing on behalf of the corporation was

                                      -46-
<PAGE>

authorized to do so; and (v) the Lease is valid and legally binding on Tenant.
Landlord does hereby covenant, represent and warrant that (i) Landlord is duly
authorized and existing corporation; (ii) Landlord is qualified to do business
in the State of California and is in good standing in the jurisdiction of its
formation; (iii) Landlord has full right and authority to enter into this Lease;
(iv) each person signing on behalf of the corporation was authorized to do so;
and (v) the Lease is valid and legally binding on Landlord.

                                   ARTICLE 39

                         NO LIGHT, AIR OR VIEW EASEMENT
                         ------------------------------

          Any diminution or shutting off of light, air or view by any structure
which may be erected on lands adjacent to or in the vicinity of the Premises
shall in no way affect this Lease, impose any liability on Landlord, or permit
Tenant to reduce, setoff or abate rent or seek any other remedies or relief.

                                   ARTICLE 40

                              EXAMINATION OF LEASE
                              --------------------

          Submission of this instrument for examination or signature by Tenant
does not constitute a reservation of or option for lease, and it is not
effective as a lease or otherwise legally binding until execution by and
delivery to both Landlord and Tenant.

                                   ARTICLE 41

                                 FORCE MAJEURE
                                 -------------

          Any covenants, conditions, provisions or agreements on the part of one
party to perform any act or thing for the benefit of the other shall not be
deemed breached if such party is unable to furnish or perform the same by virtue
of a strike, lock out, fire, earthquake, explosion, riot, material or supply
shortages, Acts of God, laws, rules, orders, ordinances, directions, regulations
or requirements of any federal, state, county or municipal authority, labor
dispute or any other cause whatsoever beyond such party's reasonable control;
provided, however, that nothing in this Article 41 shall be deemed to relieve
either party from paying the other any sums owed to the other party under this
Lease (including, in the case of Tenant, any Rent) when such sums are due.
Unless expressly provided in this Lease, Tenant's Rent shall not be abated by
reason of such inability on the part of Landlord.

                                  ARTICLE 42

                                   RECORDING
                                   ---------

          Tenant shall not record this Lease nor any form of memorandum hereof
without the prior written consent of Landlord, which consent may be withheld or
conditioned in Landlord's sole and absolute discretion. Any recording of this
Lease or any memorandum hereof without the prior written consent of Landlord
shall constitute a default by Tenant under

                                      -47-
<PAGE>

this Lease. Landlord, in its sole and absolute discretion, may record this Lease
or a memorandum hereof.

                                   ARTICLE 43

                           INCORPORATION BY REFERENCE
                           --------------------------

          The Basic Lease Provisions, Addenda (if any) and Exhibits attached
hereto all constitute parts of this Lease and any reference thereto incorporates
such matters in this Lease as if the same were fully set forth herein.

                                   ARTICLE 44

                         DEFINITION OF ADDITIONAL RENT
                         -----------------------------

          The Monthly Base Rent, Property Taxes, insurance premiums, maintenance
and repair costs incurred by Landlord under Article 6 above, and all other
amounts required to be paid by Tenant hereunder ("Additional Rent") including,
without limitation, interest, late charges, advance rent and reimbursements, are
sometimes collectively referred to in this Lease as, and shall constitute "Rent"
or "rent". Demand for payment of Rent shall not constitute a forbearance and
shall not compromise Landlord's right to deem Tenant's failure to pay such Rent
in a timely manner as a default or limit any other rights given to Landlord
under this Lease or by law or equity.

                                   ARTICLE 45

                             SURRENDER OF PREMISES
                             ---------------------

          On the Expiration Date or the earlier termination of the Lease, Tenant
shall surrender the Premises and every part and system thereof to Landlord broom
clean and in as good condition as delivered to Tenant, reasonable wear and tear,
condemnation and casualty excepted, and free of all debris and Hazardous
Materials placed on the Premises by Tenant or Tenant Parties and in full
compliance with all requirements of Section 9.6 above. Unless Landlord has
required removal pursuant to Section 7.3 above, Tenant's initial Tenant
Improvements made by or for Tenant render the Work Letter and all other
improvements, alterations and additions made by or for Tenant to the Premises in
accordance with Section 7.3 of the Lease, shall become part of the Premises on
the Expiration Date or earlier termination of this Lease and be surrendered,
together with the Premises, to Landlord in good, serviceable and operating
condition, reasonable wear and tear, condemnation and casualty excepted. Tenant
shall remove all of its trade fixtures, equipment and personal property and
signs, provided such removal will not adversely affect the structural integrity
of the Premises. Any property not so removed within ten (10) days after the
Expiration Date or earlier termination of the Lease shall be deemed abandoned by
Tenant and shall become Landlord's property which Landlord may use, remove, or
dispose of in accordance with California Civil Code Section 1980 et seq. or any
successor statutes thereto. Tenant shall reimburse Landlord for any cost
incurred by Landlord in such removal, storage or disposition, or in repairing or
restoring the Premises. Tenant shall further defend and indemnify Landlord
against all claims, losses, costs, expenses, actions,

                                      -48-
<PAGE>

judgments, damages and liabilities resulting from Tenant's failure and delay in
surrendering the Premises as above provided including, without limitation, any
claim made by any succeeding tenant of the Premises resulting from or related to
such failure to surrender, which indemnification and defense obligations shall
survive the expiration or earlier termination of this Lease.

                                   ARTICLE 46

                           NO ACCORD AND SATISFACTION
                           --------------------------

          No payment by Tenant or receipt by Landlord of a lesser amount than
due shall be deemed to be other than on account of the full amount due and
Landlord may accept such check or payment without prejudice to Landlord's rights
to recover the balance.

                                  ARTICLE 47

                                    MERGER
                                    ------

          The voluntary or other surrender of this Lease by Tenant, or a mutual
cancellation thereof, or a termination by Landlord, shall not work as a merger,
and shall, at the option of Landlord, terminate all or any existing subtenancies
or may, at the option of Landlord, operate as an assignment to Landlord of any
or all of such subtenancies.

                                   ARTICLE 48

                              FINANCIAL STATEMENTS
                              --------------------

          The Financial Statements of Tenant were submitted as an inducement and
consideration to Landlord to enter into this Lease. Tenant represents and
warrants to Tenant that the Financial Statements were true and correct as of the
date thereof. Tenant further represents

                                      -49-
<PAGE>

and warrants to Landlord that to Tenant's actual knowledge there have been no
material adverse changes in the financial condition of Tenant since the date of
the Financial Statements.

          IN WITNESS WHEREOF, the parties hereto have executed this Lease,
consisting of the foregoing Basic Lease Provisions and Articles 1 through 48,
together with Exhibits A through E, all of which are incorporated herein in
              ----------------------
their entirety by this reference, as of the date set forth above.


LANDLORD:                               TENANT:

ALZA CORPORATION, a Delaware            CHEMDEX CORPORATION, a Delaware
corporation                             corporation

By:  /s/Harold Fethe                    By:  /s/James G. Stewart
   -----------------------------------     ---------------------------------
              Harold Fethe                   James G. Stewart
Its: Sr. Vice Pres., Human Resources    Its: Chief Financial Officer
    ----------------------------------      --------------------------------




By:  /s/Peter Staple                    By:  /s/David P. Perry
   -----------------------------------     ---------------------------------
              Peter Staple                   David P. Perry
Its: Sr. Vice President & Gen. Counsel  Its: President & CEO
     ---------------------------------      --------------------------------



                                      -50-
<PAGE>

                                   EXHIBIT A
                                   ---------
                          DESCRIPTION OF REAL PROPERTY
                          ----------------------------

          All that certain real property situated in the City of Mountain View,
County of Santa Clara, State of California, described as follows:

     Beginning at a point on the general Southerly line of that certain 17.494
     more or less acre (gross) parcel of land designated as Parcel "A" on that
     certain Parcel Map filed for record in Book 557 of Maps at pages 1 and 2,
     Santa Clara County Records, distant thereon North 85(degrees) 44' 13" West
     20.05 feet from the Southeasterly corner thereof, said point of beginning
     being the intersection thereof with the Westerly line of Joaquin Road as
     shown on said Parcel Map; thence leaving said point of beginning along said
     general Southerly line of Parcel "A" along the following courses and
     distances:

     North 85(degrees) 44' 13" West 335.07 feet; South 0(degrees) 17' 27" West
     61.46 feet and North 85(degrees) 44' 13" West 335.08 feet to a point on the
     Easterly line of Huff Avenue as shown on said map; thence along said
     Easterly line North 0(degrees) 17' 32" East 64.74 feet; thence leaving said
     Easterly line South 89(degrees) 42' 28" East 263.75 feet; thence North
     0(degrees) 17' 32" East 306.02 feet South 89(degrees) 42' 28" East 404.78
     feet to a point on said Westerly line of Joaquin Road; thence along said
     Westerly line South 0(degrees) 17' 23" West 355.70 feet to the point of
     beginning.

     APN:  116-10-093
     ARB:  116-10-12 thru 17, 19, 20, 21
           22, 22.1, 23, 24, 25, 26, 27
           29, 68, 69, 71, 72

                                      -1-
<PAGE>

                                   EXHIBIT B
                                   ---------

<TABLE>
<CAPTION>
                 Lease Period                                  Monthly Base Rent
<S>                                           <C>
Original Lease Term
- -------------------

Commencement Date to 10/14/00                 $ 75,368 (subject to free rent per (S) 3.2)
10/15/00 to 10/14/01                                         $ 77,629
10/15/01 to 10/14/02                                         $ 79,958
10/15/02 to 10/14/03                                         $ 82,357
10/15/03 to 10/14/04                                         $ 84,827
10/15/04 to 02/28/05                                         $ 87,372


Extended Terms
- --------------

03/01/05 to 10/14/05                                         $ 87,372
10/15/05 to 10/14/06                                         $ 89,993
10/15/06 to 02/28/07                                         $ 92,693
</TABLE>

                                      -1-
<PAGE>

                                   EXHIBIT C
                                   ---------
                            FORM OF LETTER OF CREDIT

                             WELLS FARGO BANK, N.A.
                  TRADE SERVICES DIVISION, NORTHERN CALIFORNIA
                         525 MARKET STREET, 25TH FLOOR
                        SAN FRANCISCO, CALIFORNIA 94105

                          IRREVOCABLE LETTER OF CREDIT

ALZA Corporation                                   Letter of Credit No. NZS_____
950 Page Mill Road                                 Date:____ __, 1999
Palo Alto, CA 94304
Attention: Senior Vice President & General Counsel

Ladies and Gentlemen:

     At the request and for the account of Chemdex Corporation, 3950 Fabian Way,
Palo Alto, CA 94303, we hereby establish our Irrevocable Letter of Credit in
your favor in the amount of Six Hundred Twenty-Five Thousand United States
Dollars (US$625,000) available with us at our above office by payment of your
draft(s) drawn on us at sight in the form of Exhibit 1 hereto with the
instructions in brackets therein complied with accompanied by your signed and
dated statement in the form of Exhibit 2 hereto with the instructions in
brackets therein complied with.

     Each drawing must also be accompanied by the original of this Letter of
Credit for our endorsement on this Letter of Credit of our payment of such
drawing.

     Partial and multiple drawings are permitted under this Letter of Credit,
however each drawing must be in an amount of not less than US$20,000.00.

     If any instructions accompanying a drawing under this Letter of Credit
request the payment is to be made by transfer to an account with us or at
another bank, we and/or such other bank may rely on an account number specified
in such instructions even if the number identifies a person or entity different
from the intended payee.

     This Letter of Credit expires at our above office on July 31, 2000, but
shall be automatically extended, without written amendment, to July 31 in each
succeeding calendar year up to, but not beyond, April 30, 2005 unless we have
sent written notice to you at your address above by registered mail or express
courier that we elect not to renew this Letter of Credit beyond the date
specified in such notice (the "Non-Renewal Expiration Date"), which Non-Renewal
Expiration Date will be July 31, 2000 or any subsequent July 31 occurring before
April 30, 2005 and be at least 60 calendar days after the date we send you such
notice.

     This Letter of Credit is transferable one or more times, but in each
instance to a single transferee and only in the full amount available to be
drawn under this Letter of Credit at the

                                      -1-
<PAGE>

time of such transfer. Any such transfer may be effected only through ourselves
and only upon presentation to us at our above-specified office of a duly
executed instrument of transfer in the form attached hereto as Exhibit 3 with
the instructions in brackets therein complied with together with the original of
this Letter of Credit. Any transfer of this Letter of Credit may not change the
place of expiration of this Letter of Credit from our above-specified office.
Each transfer shall be evidenced by our endorsement on the reverse of the
original of this Letter of Credit, and we shall deliver the original of this
Letter of Credit so endorsed to the transferee. All commissions and charges in
connection with this transfer are for the account of Chemdex Corporation.

     This Letter of Credit is subject to the Uniform Customs and Practice for
Documentary Credits (1993 revision), International Chamber of Commerce
Publication No. 500, and engages us in accordance therewith.

                                       Very truly yours,

                                       WELLS FARGO BANK, N.A.


                                       BY:________________________
                                           (AUTHORIZED SIGNATURE)

                                      -2-
<PAGE>

                                   Exhibit 1
                             Wells Fargo Bank, N.A

                         Letter of Credit No._________

Wells Fargo Bank, N.A.
Trade Services Division, Northern California
525 Market Street
San Francisco, CA 94105

Attention: Manager, Standby Letter of Credit Dept.

                                     DRAFT

                                            Date of Draft: [insert date]

          To the order of [insert Beneficiary Name], pay [insert amount of
drawing in words]
UNITED STATES DOLLARS (U.S. $ [insert amount of drawing in numbers]) at sight

             For value received under Letter of Credit No._______

          "Drawn under Wells Fargo Bank, N.A. Letter of Credit No._______
dated August      ,1999."

                                            [insert Beneficiary Name]

                                            By:  [insert signature]
                                            Its: [insert title]

                                      -3-
<PAGE>

                                   Exhibit 2
                             Wells Fargo Bank, N.A

                         Letter of Credit No.________

Wells Fargo Bank, N.A.
Trade Services Division, Northern California
525 Market Street
San Francisco, CA 94105

Attention: Manager, Standby Letter of Credit Dept.

     Re: Letter of Credit No.________

Ladies and Gentlemen:

     1.  The undersigned Beneficiary, [insert Beneficiary Name], is Landlord
under that certain Office Lease dated August___, 1999 ("Lease") with Chemdex
Corporation, a Delaware corporation, as Tenant.

     2.  The undersigned Beneficiary is entitled to payment under the Lease in
the amount of U.S.$[insert amount of draft which accompanies this statement]
(the "Draw Amount") in accordance with the applicable provisions of the Lease
(as the same may have been amended to date), which is the same amount as the
Draft accompanying this Certificate and is less than or equal to the amount
currently available under the Letter of Credit.

     3.  The individual executing this Certificate on behalf of Beneficiary is a
duly authorized officer of Beneficiary.


Date: [insert date]                             [insert Beneficiary Name]

                                                By: [insert signature]
                                                Its: [insert title]

                                      -4-
<PAGE>

                                   Exhibit 3
                             Wells Fargo Bank, N.A

                          Letter of Credit No._______

                                                  Date: [insert date]

Wells Fargo Bank, N.A.
Trade Services Division, Northern California
525 Market Street, 25th Floor
San Francisco, California 94105
Attention: Manager, Standby Letter of Credit Department

Subject: Your Letter of Credit No.

Ladies and Gentlemen:

     For value received, we hereby irrevocably assign and transfer all our
rights under the above-captioned Letter of Credit, as heretofore and hereafter
amended, extended or increased, to:

               ___________________________
               [insert Name of Transferee]

               ___________________________

               ___________________________
               [insert Address of Transferee]

     By this transfer, all of our rights in the Letter of Credit are transferred
to the transferee, and the transferee shall have sole rights as beneficiary
under the Letter of Credit, including sole rights relating to any amendments,
whether increases or extensions or other amendments, and whether now existing or
hereafter made. You are hereby irrevocably instructed to advise future
amendment(s) of the Letter of Credit to the transferee without our consent or
notice to us.

     You are hereby advised that [ insert Name of Transferee] succeeded to all
of beneficiary's right, title and interest under that certain Office Lease dated
August___, 1999 (as the same may have been amended to date), with Chemdex
Corporation, a Delaware corporation, as Tenant.

     Enclosed are the original Letter of Credit and the original of all
amendments to this date. Please notify the transferee of this Transfer and of
the terms and conditions of the Letter of

                                      -5-
<PAGE>

Credit as transferred. All fees and charges in connection with this Transfer are
for the account of Chemdex Corporation

                                    Very truly yours,

                                    [Insert Name of Beneficiary]

                                    By:  [insert signature]
                                    Its: [insert title]

Signature of Transferor Guaranteed
[Insert Name of Bank]
By: [insert signature]
Name:  [insert typed or printed name]
Title: [insert title]

                                      -6-
<PAGE>

                                   EXHIBIT D
                                   ---------

                      WORK LETTER FOR TENANT IMPROVEMENTS

     1.  Delivery of Possession. Landlord shall deliver possession of the
         ----------------------
Premises to Tenant in "AS-IS" and "WITH ALL FAULTS" condition on the
Commencement Date (as defined in Section 2.1 of the Lease) to permit Tenant and
the Contractor Group (defined below) to commence and diligently pursue to
completion the Tenant Improvements (defined below) within the Premises. Tenant
acknowledges that Landlord has no obligation whatsoever to alter, repair,
restore, upgrade or improve the Premises under this Work Letter for Tenant
Improvements ("Work Letter"). As used herein, "Contractor Group" shall mean the
General Contractor (defined below) and each of its subcontractors, sub-
subcontractors, laborers, materialmen and suppliers providing labor or materials
to the Tenant Improvements. Capitalized terms used in this Work Letter and not
defined herein shall have the meanings given them in the Lease.

     2.  Tenant Improvements. Tenant, at its sole cost and expense, shall
         -------------------
construct and install within the Premises its desired tenant improvements and
other improvements in accordance with the Approved Working Drawings (defined
below), which tenant improvements may include, without limitation, (i)
demolition of certain limited existing interior walls and other improvements
within the Premises, (ii) construction, installation and/or reconfiguration of
certain ceilings, interior walls and partitions, interior finishing of exterior
walls (including, without limitation, the plastering, furring, drywalling,
taping and/or other finishing of such walls), interior doors, floor coverings
and the preparation of all floors for same, cabinetry and millwork, restrooms,
light fixtures, wall coverings and other improvements, finishings and painting
within the Premises, (iii) modifications to floors for above-normal floor
loading requirements of Tenant, (iv) modifications reasonably required by Tenant
to the heating, ventilating and air conditioning ("HVAC") systems, ducts and
means of distribution for the same within the Premises, (v) improvements,
additions, alterations and fixtures within the buildings on the Premises
necessary for all Tenant Improvements and all portions of all buildings affected
by the Tenant Improvements to comply with all applicable codes, statutes, rules,
regulations, ordinances and orders of any federal, state, county or municipal
agency having jurisdiction over the Premises including all local, state and
federal requirements for disability access including, without limitation, the
Americans With Disabilities Act, 42 U.S.C. Section 1201 et seq. and California
Government Code Section 4450 et seq. (collectively, "ADA"), (vi) all telephone,
telecommunication, computer and data systems, switch room, cabling, lines,
conduit, receptacles, switches and related equipment and improvements running
from point of entry in the Premises, and (vii) all other necessary, desirable or
required improvements, alterations, fixtures and finishes which are to be
installed within or incorporated into the Premises by Tenant (collectively, the
"Tenant Improvements"). Tenant shall commence to construct and install the
Tenant Improvements at Tenant's sole cost and expense promptly from and after
Commencement Date and diligently pursue to completion, subject to Force Majeure
delays, the construction of all Tenant Improvements.

                                      -1-
<PAGE>

     3.   Working Drawings.
          -----------------


          3.1  Selection of Architect and Engineer; Working Drawings. Tenant
               -----------------------------------------------------
shall retain a reputable architect (the "Architect") to the extent required by
Landlord and as approved by Landlord, which approval shall not be unreasonably
withheld or delayed, to prepare the "Working Drawings", as that term is defined
in this Section 3.1. No Working Drawings shall be required for carpeting,
painting and other di minimus improvements within the Premises. If necessary to
construct or install the Tenant Improvements, Tenant shall also retain an
engineering design build contractor (the "Engineer") approved by Landlord, which
approval shall not be unreasonably withheld or delayed, to prepare all plans and
engineering working drawings relating to any HVAC work or reconfiguration to be
performed by or for Tenant in the Premises. If Landlord fails to disapprove
Tenant's proposed Architect or Engineer in writing to Tenant, as the case may
be, within five (5) business days after receipt of written notice from Tenant
identifying the same, then Landlord shall be deemed to have approved Tenant's
proposed Architect or Engineer, as the case may be. The plans and drawings to be
prepared by Architect and the Engineer (if any) hereunder are collectively
referred to herein as the "Working Drawings." All Working Drawings shall be
subject to Landlord's approval, which approval shall not be unreasonably
withheld or delayed. Landlord shall advise Tenant within ten (10) business days
after Landlord's receipt of the proposed Working Drawings if the Working
Drawings are unsatisfactory, with a reasonable description of any matters found
to be not acceptable to Landlord. If Landlord fails to return Tenant's proposed
Working Drawings to Tenant marked "Approved", "Approved as Noted" or
"Disapproved" within said ten (10) business-day period, then Landlord shall be
deemed to have approved Tenant's proposed Working Drawings. Tenant's Working
Drawings, as finally revised and marked or deemed approved by Landlord, shall be
initialed by Landlord and Tenant and shall be referred to as the "Approved
Working Drawings". If Approved Working Drawings are not agreed upon within five
(5) business days after delivery to Tenant of "Disapproved" Working Drawings or
"Approved as Noted" Working Drawings, then Landlord or Tenant may submit the
disputed items to an arbitration panel consisting of Landlord's architect, an
architect appointed by Tenant (who may be the Architect who prepared Tenant's
Working Drawings), and a third architect appointed by said architects. Tenant
shall appoint its architect within five (5) business days after written notice
from Landlord. The majority decision of such panel shall be made within five (5)
business days after appointment of said third architect and such decision shall
be binding upon Landlord and Tenant and judgment upon the decision of the
arbitrators may be entered in any court having jurisdiction. Landlord and Tenant
shall each pay the fees of their own architect and one-half (1/2) of the fees of
the third architect.

          3.2  Space Plan. Tenant shall cause a space plan ("Space Plan") for
               ----------
the Tenant Improvements to be prepared (including a layout and designation of
all offices, stairways, stairwells, elevators, utility rooms, storage areas,
conference and meeting rooms and other partitioning within the Premises). The
Space Plan shall be subject to Landlord's approval, which approval shall not be
unreasonably withheld or delayed. Landlord shall advise Tenant within ten (10)
business days after Landlord's receipt of the proposed Space Plan if the Space
Plan is unsatisfactory, with a reasonable description of any matters found to be
not acceptable to Landlord. If Landlord fails to return Tenant's proposed Space
Plan to Tenant marked "Approved", "Approved as Noted" or "Disapproved" within
said ten (10) business-day period,

                                      -2-
<PAGE>

then Landlord shall be deemed to have approved Tenant's proposed Space Plan.
Tenant's Space Plan, as finally revised and marked or deemed approved by
Landlord, shall be initialed by Landlord and Tenant and shall be referred to as
the "Approved Space Plan". If the Approved Space Plan is not agreed upon within
five (5) business days after delivery to Tenant of a "Disapproved" Space Plan or
an "Approved as Noted" Space Plan, then Landlord or Tenant may submit the
disputed items to an arbitration panel as provided in Section 3.1 above. Any
material revisions or amendments to the Approved Space Plan shall require
Landlord's prior written approval not to be unreasonably withheld or delayed.

          3.3  INTENTIONALLY DELETED

          3.4  Approved Working Drawings. Tenant shall, at Tenant's sole cost
               -------------------------
and expense, submit the Approved Working Drawings to the City of Mountain View
to the extent necessary to obtain any and all demolition, building and other
governmental permits as may be required by law to commence construction of the
Tenant Improvements. Tenant hereby agrees that neither Landlord nor Landlord's
consultants shall be responsible for obtaining any permits or certificates of
occupancy or other occupancy permits or approvals for the Premises and that the
obtaining of the same if required by law shall be Tenant's sole responsibility
at Tenant's sole cost. No material modifications to the Approved Working
Drawings may be made without the prior written consent of Landlord, which
consent shall not be unreasonably withheld or delayed. If Landlord fails to
disapprove any proposed, modifications to the Approved Working Drawings within
five (5) business days after receipt of written notice from Tenant or its
Architect identifying the same, then Landlord shall be deemed to have approved
such proposed modifications. Construction of the Tenant Improvements by Tenant
and the Contractor Group shall not commence unless and until Tenant has obtained
all legally required demolition, building and other governmental permits
necessary for commencing construction of the Tenant Improvements and delivered
copies of all such permits to Landlord.

          3.5  Approvals Not Binding on Landlord. Landlord's and Landlord's
               ---------------------------------
consultants' review of the Working Drawings and Space Plan as set forth in this
Section 3 shall be for Landlord's sole purpose and shall not imply any
representation or warranty as to the adequacy or sufficiency of the same by
Landlord or Landlord's construction manager, space planners, architects,
engineers and consultants, or obligate Landlord to review the same for quality,
design, code compliance or other like matters. Accordingly, notwithstanding that
any Working Drawings or Space Plan are reviewed by Landlord or its consultants,
and notwithstanding any advice or assistance which may be rendered to Tenant by
Landlord or Landlord's consultants, Landlord and Landlord's construction
manager, space planner, architect, engineers and consultants shall have no
liability whatsoever for such review or advice and shall not be responsible for
any omissions or errors contained in the Working Drawings, Space Plan, Approved
Working Drawings, or Approved Space Plans of any nature whatsoever.

     4.   Construction of Tenant Improvements. Tenant, at Tenant's sole cost and
          -----------------------------------
expense, shall perform or cause to be constructed within the Premises all of the
Tenant Improvements in accordance with the Approved Working Drawings and only
after receipt of all demolition, building and other governmental permits as may
be required by law to commence construction of the Tenant Improvements. No
materials used in the Tenant Improvements shall be subject to any

                                      -3-
<PAGE>

security interest or lien. All materials (as well as methods and processes) used
in the performance of the Tenant Improvements shall be of new and first-class
quality. Tenant shall ensure that its General Contractor and members of the
Contractor Group are familiar with all those portions of the Premises upon or
within which the Tenant Improvement Work will be performed. The Tenant
Improvements as constructed shall not materially alter or affect the exterior
appearance or the structure of the Premises or any of the mechanical,
electrical, plumbing, HVAC or other building systems serving the Premises,
unless such alterations or modifications are provided for in the Approved
Working Drawings or otherwise expressly agreed to in writing by Landlord. All
Tenant Improvements shall be performed diligently (subject to Force Majeure
delays), in a good and workmanlike manner and in accordance with any and all
applicable codes, statutes, rules, regulations, ordinances and orders of any
federal, state, county or municipal agency or other governmental body having
jurisdiction over the Premises, including, without limitation, the ADA, the
Uniform Building Code, California Health and Safety Code (S)(S) 19955 et seq.,
OSHA, 29 U.S.C. (S)(S) 651 et seq. and CAL-OSHA. During the Term or any Extended
Term, Landlord shall not be responsible for repairing or otherwise correcting
any defects in the Tenant Improvements (including any failure of the Tenant
Improvements to comply with applicable laws) that may occur during or after
completion of construction whether such defects affect the Premises or any part
thereof. Except as may be permitted under the Approved Working Drawings, Tenant
shall not demolish, remove or alter any structural portion of the Premises
without Landlord's prior written consent, which Landlord agrees not unreasonably
withhold or delay. All Tenant Improvements shall be constructed in a manner that
will minimize, to the extent reasonably practicable under the circumstances
interference with and inconvenience to Landlord's use or occupancy of the first
floor of the 1010 Joaquin building, or with the use or occupancy of the 1010
Joaquin building by any other tenant of the 1010 Joaquin building, if any, and
reasonable complaints from Landlord (in its capacity as an occupant of the first
floor of the 1010 Joaquin building) or from any other tenants of the 1010
Joaquin building, if any, shall be promptly remedied by Tenant.

     5.   Tenant's General Contractor and Construction Contract. Tenant shall
          -----------------------------------------------------
have the right to solicit bids from duly licensed reputable contractors for
construction and installation of the Tenant Improvements. Landlord shall have
the right to approve, within five (5) business days of full and complete
submittal to Landlord, each of Tenant's general contractors for the Tenant
Improvements and the form of construction contract to be entered into between
Tenant and such general contractor with respect to the construction and
installation of the Tenant Improvements, and those subcontractors and forms of
subcontracts for subcontracts where the subcontractor is providing work,
materials and/or supplies in excess of $100,000 (collectively, $100,000
Subcontractors" and "$100,000 Subcontracts", as applicable), which approvals
shall not be unreasonably withheld or delayed. Any disapproval of any of the
foregoing by Landlord shall contain a reasonable description of any matters
found to be not acceptable to Landlord. If Landlord fails to approve or
disapprove Tenant's proposed general contractor within said five (5)-business-
day period (and Landlord hereby preapproves Vance Brown Contractors) or to
return Tenant's proposed construction contract to Tenant marked "Approved,"
"Approved as Noted," or "Disapproved" within said five (5)-business-day period,
then Landlord shall be deemed to have approved the same. The construction
contract for the Tenant Improvements (the "Construction Contract") between
Tenant and the general contractor approved (or deemed approved) by Landlord (the
"General Contractor") shall provide, and Tenant shall exercise

                                      -4-
<PAGE>

commercially reasonable efforts to cause each of the $100,000 Subcontracts with
the $100,000 Subcontractors to provide, that: (i) the General Contractor and
each $100,000 Subcontractor shall leave all common areas (if any) at the
Premises affected by their work in a neat, orderly and safe condition at the end
of each day during construction of the Tenant Improvements; (ii) the General
Contractor and each $100,000 Subcontractor shall procure and maintain the
insurance described in Section 7 below; (iii) to the fullest extent permitted by
law, the General Contractor and each $100,000 Subcontractor shall indemnify,
defend (with counsel reasonably acceptable to Landlord) and hold Landlord and
its officers, directors, employees and contractors harmless from and against any
injury or death to any person or damage to any property in or about the Premises
resulting from the activities of the indemnifying party, except to the extent
that such injury, death or damage results directly from negligence or willful
misconduct of Landlord or its contractors, employees or agents; (iv) the General
Contractor and each $100,000 Subcontractor shall guarantee to Tenant for the
benefit of Tenant and Landlord that the portion of the Tenant Improvements for
which it is responsible has been completed in accordance with the Approved
Working Drawings and shall be free from any defects in workmanship and materials
for a period of not less than one (1) year from the date of completion thereof
and that the General Contractor and applicable $100,000 Subcontractor shall be
responsible for the replacement or repair, without additional charge, of all
workmanship or materials provided by the General Contractor pursuant to the
Construction Contract or $100,000 Subcontract that may become defective within
said one (1)-year period.

     6.   Indemnification. Tenant hereby confirms and agrees that Tenant's
          ---------------
indemnification and defense obligations set forth in Articles 9 and 19 of the
Lease are incorporated in full into this Work Letter as though fully set forth
herein and shall apply to all of Tenant's and the Contractor Group's
construction activities at the Premises and all work related activities
performed at the Premises by or through Tenant and the Contractor Group
hereunder during the Term. Without diminishing Tenant's rights against the
General Contractor or any other member of the Contractor Group, Tenant hereby
assumes all risk of injury or death to persons or damage to property at the
Premises and all costs relating to non-compliance with applicable laws at the
Premises caused by Tenant's construction activities at the Premises, except to
the extent such injury, death or damage is caused by Landlord's or any Landlord
Party's negligence or willful misconduct. The indemnification obligations set
forth in this Section 6 shall not be limited by available insurance proceeds and
shall survive the termination or expiration of the Lease and this Work Letter.

     7.   Insurance. Tenant shall cause Tenant's General Contractor and each
          ---------
member of the Contractor Group to maintain worker's compensation insurance with
statutory benefits and limits. Tenant shall cause Tenant's General Contractor,
and shall exercise commercially reasonable efforts to cause each $100,000
Subcontractor, to maintain comprehensive liability and property damage insurance
in an amount of not less than Two Million Dollars ($2,000,000) per occurrence
($1,000,000 for $100,000 Subcontractors) with companies and on forms reasonably
satisfactory to Landlord in its reasonable discretion. Tenant, the General
Contractor and each $100,000 Subcontractor shall, prior to commencing any work
hereunder and at all times during the entire period of construction of the
Tenant Improvements, keep current and valid certificates of the insurance
required of it hereunder on file with Landlord. Except for worker's compensation
insurance, all policies of insurance shall name Landlord and its respective

                                      -5-
<PAGE>

directors, officers, employees and agents as additional insureds, provide that
the insurance coverage is primary and noncontributing with any insurance carried
by Landlord, waive subrogation against Landlord with respect to property damage,
cover Tenant's indemnification obligations set forth in Section 6 above and
contain a provision giving Landlord at least thirty (30) days prior written
notice of any cancellation or material change in any insurance coverage.

     8.   Builder's Risk Insurance. Tenant, at Tenant's sole cost and expense,
          ------------------------
shall procure and maintain (or cause Tenant's contractor to procure and
maintain) during the construction of the Tenant Improvements Builder's Risk
Insurance covering One Hundred Percent (100%) of the replacement cost of all of
the Tenant Improvements, including all materials and equipment destined to
become part of the Tenant Improvements. Such insurance shall include the perils
of fire, extended coverage, vandalism and malicious mischief, and so-called "All
Risk" perils as defined and limited in the policies, but may, at Tenant's
option, exclude the perils of earthquake and flood. If during the course of
their construction any of the Tenant Improvements are damaged by a casualty
event required to be insured against by Tenant under this Section, Tenant shall
promptly repair such casualty damage (or cause the same to be repaired).

     9.   Landlord's Inspection Rights. During the course of construction of the
          ----------------------------
Tenant Improvements Landlord reserves the right to inspect the progress of the
Tenant Improvements on the terms set forth in Section 16.1 of the Lease;
provided, however, that such inspection(s) shall in no way make Landlord
responsible for any of the work of construction of the Tenant Improvements and,
as more particularly set forth in Section 3.5 above, shall not constitute a
representation or warranty by Landlord as to the design, adequacy or sufficiency
of the Tenant Improvements.

     10.  Notice of Nonresponsibility. Tenant shall give Landlord not more than
          ---------------------------
twenty (20) and not less than ten (10) business days prior written notice of the
date on which the first construction of the Tenant Improvements is scheduled to
commence to permit Landlord to post on the Premises and record with the Santa
Clara County Recorder appropriate notices of nonresponsibility.

     11.  Payments by Tenant; Liens. All costs and expenses relating to the
          -------------------------
Tenant Improvements shall be paid promptly by Tenant as they come due and
evidence of such payment shall be furnished to Landlord upon request. Tenant
shall cause any mechanic's or materialman's lien or other claim filed against
the Premises and relating to the Tenant Improvements to be released and removed
in accordance with the applicable provisions of the Lease notwithstanding any
other dispute Tenant may then have with Landlord. Should Tenant fail to remove
any such lien within the required period of time, Landlord may (at its sole
election) pay or bond over such claim and the amount paid or premium for the
bond, together with any attorneys' fees and costs incurred by Landlord in
connection therewith, shall be immediately due from Tenant to Landlord. Promptly
following completion of any portion of the Tenant Improvements by the General
Contractor and each $100,000 Subcontractor, Tenant shall deliver to Landlord
waivers of mechanic's liens executed by each such person with respect to the
completed portion of such Tenant Improvements. Promptly following completion of
the entire Tenant Improvements, Tenant shall obtain and deliver to Landlord an
unconditional waiver and

                                      -6-
<PAGE>

release upon payment (in the form prescribed by California Civil Code Section
3262) from the General Contractor and each $100,000 Subcontractor.

     12.  Notice of Completion; Copy of "As Built" Plans. Within ten (10) days
          ----------------------------------------------
after final completion of construction of the Tenant Improvements, Tenant shall
cause a Notice of Completion to be recorded in the office of the Recorder of the
County of Santa Clara in accordance with Section 3093 of the California Civil
Code or any successor statute, and shall furnish a copy thereof to Landlord upon
such recordation. At the conclusion of construction, (i) Tenant shall cause the
Architect and Contractor (A) to update the Approved Working Drawings as
necessary to reflect all changes made to the Approved Working Drawings during
the course of construction, and (B) to deliver to Landlord two (2) sets of
sepias of "record-set" drawings within ninety (90) days following issuance of a
certificate of occupancy for the Premises, and (ii) Tenant shall deliver to
Landlord a copy of all warranties, guaranties, and operating manuals in Tenant's
possession relating to the Tenant Improvements.

     13.  Compliance with Rules and Regulations. All of Tenant's and the
          -------------------------------------
Contractor Group's activities at the Premises shall comply with any and all
easements, covenants, conditions and restrictions affecting the Premises and any
rules and regulations attached to the Lease.

     14.  Lease Provisions Apply. Nothing in this Work Letter, including
          ----------------------
Tenant's entry into the Premises for construction of the Tenant Improvements
under this Work Letter, shall relieve either Landlord or Tenant from observing
all of the terms, covenants and conditions of the Lease required to be performed
by such party including, without limitation, all indemnification and insurance
provisions of the Lease which shall apply in full to Tenant's construction of
its Tenant Improvements, and all of the provisions of the Lease are hereby
incorporated into and made a part of this Work Letter.

     15.  Landlord's Cooperation. Upon Tenant's request, Landlord shall
          ----------------------
reasonably cooperate with Tenant, at Tenant's sole cost and expense and at no
cost to Landlord, without any liability whatsoever on Landlord's part and
without Landlord having to commit any of its staff or resources, in connection
with Tenant's construction and installation of its Tenant Improvements within
the Premises and Tenant's applications for permits, certificates and approvals
associated therewith.

     16.  No Third Party Beneficiaries. This Work Letter is made and entered
          ----------------------------
into for the sole benefit of Landlord, Tenant, any other party that may be
expressly stated in this Work Letter

                                      -7-
<PAGE>

to benefit for this Work Letter or any provision hereof, and their respective
successors and assigns. No other persons or entities shall have any rights or
benefits under or arising out of this Work Letter.

          IN WITNESS WHEREOF, Landlord and Tenant have executed this Work Letter
as of the date and year first above written.

LANDLORD:                               TENANT:


ALZA CORPORATION, a Delaware            CHEMDEX CORPORATION, a Delaware

corporation                             corporation


By: /s/Harold Fethe                     By: /s/James G. Stewart
   ---------------------------------       ---------------------------------
            Harold Fethe                           James G. Stewart

Its: Sr. Vice Pres., Human Resources    Its: Chief Financial Officer
    --------------------------------        --------------------------------

By: /s/Peter Staple                     By: /s/David P. Perry
   ---------------------------------       ---------------------------------
            Peter Staple                           David P. Perry

Its: Sr. Vice Pres. & General Counsel   Its: President & CEO
     -------------------------------        --------------------------------


                                      -8-
<PAGE>

                                   EXHIBIT E
                                   ---------

                TERMS TO BE INCORPORATED IN LEASE SUBORDINATION,
                    ATTORNMENT AND NONDISTURBANCE AGREEMENT


     THIS AGREEMENT is made this _____ day of ______________, by and between
CHEMDEX CORPORATION, a Delaware Corporation ("Tenant") and _________________
_______________ ("Lender"):

                                    RECITALS

     A. Lender is the holder of that certain promissory note ("Note") issued by
ALZA CORPORATION ("Landlord") dated ________________ in the principal sum of ___
_______________ DOLLARS ($______) and of the deed of trust recorded on ______
____________ ("Mortgage"), which Mortgage encumbers the real property (the
"Mortgaged Property") commonly known as the entire Second Floor of 1010 Joaquin
Road, Mountain View, California, which Mortgaged Property is more particularly
described in the Mortgage.

     B. Landlord and Tenant entered into that certain Office Lease ("Lease")
dated August 13, 1999, by which Tenant leased from Landlord the Mortgaged
Property, all as more fully described in the Lease.

     C. Tenant desires to be able to obtain the advantages of the Lease and
occupancy thereunder in the event of foreclosure of the Mortgage and Lender
wishes to have Tenant confirm the priority of the Mortgage over the Lease as the
Lease relates to the Mortgaged Property.

     NOW, THEREFORE, in consideration of the mutual covenants and conditions set
forth hereinbelow, the parties hereto agree as follows:

     1. Tenant hereby covenants and agrees that all its rights, title and
interest whatsoever under the Lease as the Lease relates to the Mortgaged
Property is and shall at all times be and remain unconditionally subject and
subordinate to lien and charge of the Mortgage and to all the terms, conditions
and provisions thereof, to all advances made or to be made thereunder or under
the Note, and to any increases, renewals, extensions, modifications,
substitutions, consolidations or replacements thereof or of the Note and the
Mortgage.

     2. So long as Tenant is not in default (beyond any period given Tenant in
the Lease to cure such defaults) in the payment of rent or additional charges or
in the performance of any of the other terms, covenants or conditions of the
Lease on Tenant's part to be performed, Tenant shall not be disturbed by Lender
in its possession of the Mortgaged Property during the term of the Lease, or any
extension or renewal thereof, or in the enjoyment of its rights under the Lease.

     3. If the interest of the Landlord under the Lease as the Lease relates to
the Mortgaged Property shall be acquired by Lender or any purchaser
("Purchaser") by reason of exercise of the power of sale or the foreclosure of
the Mortgage or other proceedings brought to enforce the rights of the holder
thereof, by deed in lieu of foreclosure or by any other method, and Lender or

                                      -1-
<PAGE>

Purchaser succeeds to the interest of Landlord under the Lease, Tenant shall
attorn to Lender or Purchaser as its landlord, said attornment to be effective
and self-operative without the execution of any other instruments on the part of
either party hereto immediately upon Lender's or Purchaser's succeeding to the
interest of the Landlord under the Lease, and the Lease shall continue in
accordance with its terms between Tenant as tenant and Lender or Purchaser as
landlord, provided however that:

          (a) Lender shall not be personally liable under the Lease and Lender's
liability under the Lease shall be limited to the equity interest of Lender in
the Mortgaged Property as provided in Section 25.3 of the Lease;

          (b) Lender shall not be liable for any act or omission of any prior
landlord (including Landlord);

          (c) Lender shall not be subject to any offsets or defenses which
Tenant might have against any prior landlord (including Landlord);

          (d) Lender shall not be liable for any damages or other relief
attributable to any prior latent defects in the Mortgaged Property; and

          (e) Lender shall not be bound by any prepayment of rent, additional
rent or deposit, rental security, letter of credit or any other sums deposited
with any prior landlord (including Landlord) under the Lease unless actually
received by Lender.

     4. Tenant certifies to Lender that except as provided below, (i) the Lease
is presently in full force and effect with no defaults thereunder by Landlord or
by Tenant and unmodified; (ii) the term thereof has commenced and the full
rental is now accruing thereunder, (iii) Tenant has accepted possession of the
Premises and that any improvements required by the terms of the Lease to be made
by Landlord have been completed to the satisfaction of Tenant; (iv) no rent
under the Lease has been paid more than thirty (30) days in advance of its due
date; (v) the address for notices to be sent to Tenant is as set forth in the
Lease; and (vi) Tenant has no charge, lien, claim or offset under the Lease or
otherwise, against rents or other charges due or to become due thereunder.

     5. Tenant agrees with Lender that from and after the date hereof, Tenant
will not terminate or seek to terminate the Lease by reason of my act or
omission of Landlord thereunder until Tenant shall have given written notice, by
registered or certified mail, return receipt requested, of said act or omission
to Lender, which notice shall be addressed to Lender and until the grace period
as set forth in the Lease shall have elapsed following the giving of such
notice, during which period Lender shall have the right, but shall not be
obligated, to remedy such act or omission.

     6. Nothing in this Agreement shall be deemed to be or construed to be an
agreement by Lender to perform any covenant of Landlord under the Lease unless
and until it obtains title to the Mortgaged Property by power of sale or
judicial foreclosure or deed in lieu thereof or obtains possession of the
Property pursuant to the terms of the Mortgage.

                                      -2-
<PAGE>

     7. This Agreement shall inure to the benefit of and shall be binding upon
Tenant and Lender, and their respective heirs, personal representatives,
successors and assigns. This Agreement may not be altered, modified or amended
except in writing signed by all of the parties hereto. In the event any one or
more of the provisions contained in this Agreement shall for any reason be held
to be invalid, illegal or unenforceable in any respect, such invalidity,
illegality or unenforceability shall not affect any other provisions of this
Agreement, but this Agreement shall be construed as if such invalid, illegal or
unenforceable provision had never been contained herein. This Agreement shall be
governed by and construed according to the laws of the State of California.

     IN WITNESS WHEREOF, Lender and Tenant have executed this Agreement as of
the date and year first above written.


LENDER:                                TENANT:
                                       CHEMDEX CORPORATION, a
                                       Delaware Corporation

By:___________________________         By:____________________________

Its:__________________________         Its:___________________________

                                      -3-

<PAGE>

                                  SCHEDULE 2


                    List of Groundwater Monitoring Reports


     1.  Letter dated May 15, 1998 from the San Francisco Bay Regional Water
Quality Control Board to ALZA Corporation concerning 1500/1550 Plymouth Street,
Mountain View.

     2.  Letter and Summary of Environmental Condition dated June 17, 1999 from
Aquifer Services, Inc. to ALZA Corporation concerning 1500/1550 Plymouth Street
and 1010 Joaquin Road, Mountain View.

     3.  Groundwater Monitoring Report for the Quarterly Reporting Period
January 1 through March 31, 1999 prepared for Spectra-Phipers Lasers, Inc. and
Teledyne Semiconductor dated April 30, 1999.

                                      -1-
<PAGE>

                                  SCHEDULE 3
                                  ----------

     Routes of Building Access for CHEMDEX at 1010 Joaquin Rd. (BLDG. M4)

                                 [Floor Plan]
<PAGE>

                          Building M4 - Second Floor

                                 [Floor Plan]
<PAGE>

                    Estimated Furniture Value in Bldg. M4-2

<TABLE>
<CAPTION>
- ---------------------------------------------------------------------------------------------------------------
                   Description                         Brand          Quantity    New Cost Ea     Cost Total
- ---------------------------------------------------------------------------------------------------------------
<S>                                            <C>                    <C>         <C>             <C>
    Bookcase: Short 42" - 48"                  Various Laminate              12      $  260.00      $  3,120.00
- ---------------------------------------------------------------------------------------------------------------
    Bookcase: Short 42" - 48"                  Various Metal                  1      $  180.00      $    180.00
- ---------------------------------------------------------------------------------------------------------------
    Bookcase: Short 42" - 48"                  Various Wood                   5      $  550.00      $  2,750.00
- ---------------------------------------------------------------------------------------------------------------
    Bookcase: Tall 55" - 72"                   Various Metal                  1      $  225.00      $    225.00
- ---------------------------------------------------------------------------------------------------------------
    Bookcase: Tall 55" - 72"                   Various Wood                  10      $  950.00      $  9,500.00
- ---------------------------------------------------------------------------------------------------------------
    Cabinet, Metal Utility                     Various                        6      $  450.00      $  2,700.00
- ---------------------------------------------------------------------------------------------------------------
    Cabinet, Wood                              Various                        1      $1,200.00      $  1,200.00
- ---------------------------------------------------------------------------------------------------------------
    Chair, Conf Room                           Various                       41      $  500.00      $ 20,500.00
- ---------------------------------------------------------------------------------------------------------------
    Chair, Exec                                Various                       12      $  800.00      $  9,600.00
- ---------------------------------------------------------------------------------------------------------------
    Chair, Side                                Various                       46      $  300.00      $ 13,800.00
- ---------------------------------------------------------------------------------------------------------------
    Chair, Side: Wood                          Steelcase                     10      $  240.00      $  2,400.00
- ---------------------------------------------------------------------------------------------------------------
    Chair, Lobby                               Various                        4      $  600.00      $  2,400.00
- ---------------------------------------------------------------------------------------------------------------
    Chair, Lunch Room                          Various                       10      $  180.00      $  1,800.00
- ---------------------------------------------------------------------------------------------------------------
    Chair, Task                                Steelcase Criterion           42      $  500.00      $ 21,000.00
- ---------------------------------------------------------------------------------------------------------------
    Chair, Task                                Various                      157      $  500.00      $ 78,500.00
- ---------------------------------------------------------------------------------------------------------------
    Credenza, Laminate                         Various                        3      $  550.00      $  1,650.00
- ---------------------------------------------------------------------------------------------------------------
    Credenza, Wood                             Various                       15      $  850.00      $ 12,750.00
- ---------------------------------------------------------------------------------------------------------------
    Cubicle, approx 8'x10'                     Steelcase 9000                47      $6,000.00      $282,000.00
- ---------------------------------------------------------------------------------------------------------------
    Desk, 3-Part Laminate                      Sequus                         3      $1,200.00      $  3,600.00
- ---------------------------------------------------------------------------------------------------------------
    Desk, Laminate                             Various                        8      $  550.00      $  4,400.00
- ---------------------------------------------------------------------------------------------------------------
    Desk, Large Wood 36"x72"                   Various                       16      $  650.00      $ 10,400.00
- ---------------------------------------------------------------------------------------------------------------
    Desk, Metal w/Wood Dbl Ped                 Various                       22      $  800.00      $ 17,600.00
- ---------------------------------------------------------------------------------------------------------------
    Desk, w/Return                             Steelcase 9000                19      $1,630.00      $ 30,970.00
- ---------------------------------------------------------------------------------------------------------------
    Desk, w/Return                             Various Wood/Metal             6      $  500.00      $  3,000.00
- ---------------------------------------------------------------------------------------------------------------
    Desk, Wood, Exec 36"x72"                   Steelcase                      8      $2,500.00      $ 20,000.00
- ---------------------------------------------------------------------------------------------------------------
    Desk, Wood, Small 30"x60"                  Various                       12      $  700.00      $  8,400.00
- ---------------------------------------------------------------------------------------------------------------
    File Cabinet, 2-Drawer                     Various                       34      $  365.00      $ 12,410.00
- ---------------------------------------------------------------------------------------------------------------
    File Cabinet, 3-Drawer                     Various                       12      $  500.00      $  6,000.00
- ---------------------------------------------------------------------------------------------------------------
    File Cabinet, 4-Drawer                     Various                       57      $  800.00      $ 45,600.00
- ---------------------------------------------------------------------------------------------------------------
    File Cabinet, 5-Drawer                     Various                       54      $2,500.00      $135,000.00
- ---------------------------------------------------------------------------------------------------------------
    File Cabinet, Vertical                     Various                       14      $  250.00      $  3,500.00
- ---------------------------------------------------------------------------------------------------------------
    File Cabinet, Misc                         Various                       13      $  300.00      $  3,900.00
- ---------------------------------------------------------------------------------------------------------------
    File Cabinet, 4-Dr Fire-Proof              Fire-King                      2      $4,000.00      $  8,000.00
- ---------------------------------------------------------------------------------------------------------------
    File, Flat                                 Wood                           2      $2,500.00      $  5,000.00
- ---------------------------------------------------------------------------------------------------------------
    Keyboard Trays                             WorkRite (85%)               109      $  200.00      $ 21,800.00
- ---------------------------------------------------------------------------------------------------------------
    Safe, Large                                Various                        1      $4,000.00      $  4,000.00
- ---------------------------------------------------------------------------------------------------------------
    Table, Computer                            Various                        6      $  350.00      $  2,100.00
- ---------------------------------------------------------------------------------------------------------------
    Table, Conference Room                     Various                        3      $5,000.00      $ 15,000.00
- ---------------------------------------------------------------------------------------------------------------
    Table, Large Round                         Various                        8      $  750.00      $  6,000.00
- ---------------------------------------------------------------------------------------------------------------
    Table, Lunch                               Laminate/Metal                 2      $  450.00      $    900.00
- ---------------------------------------------------------------------------------------------------------------
    Table, Misc                                Various                       17      $  300.00      $  5,100.00
- ---------------------------------------------------------------------------------------------------------------
    Table, Printer/Computer                    Various                        3      $  250.00      $    750.00
- ---------------------------------------------------------------------------------------------------------------
    Table, Small Round                         Various                       13      $  265.00      $  3,445.00
- ---------------------------------------------------------------------------------------------------------------
    Table, Task 30x60                          Various                        5      $  350.00      $  1,750.00
- ---------------------------------------------------------------------------------------------------------------
    Table, Training                            Various                        6      $  650.00      $  3,900.00
- ---------------------------------------------------------------------------------------------------------------
                                                                                                    $856,190.00
- ---------------------------------------------------------------------------------------------------------------
</TABLE>


August 13, 1999           Estimated Furniture Value                            1
                                  Bldg. M4-2

<PAGE>

[LOGO OF WELLS FARGO]

                            WELLS FARGO BANK, N.A.
                 TRADE SERVICES DIVISION, NORTHERN CALIFORNIA
                         525 MARKET STREET, 25TH FLOOR
                        SAN FRANCISCO, CALIFORNIA 94105

                         IRREVOCABLE LETTER OF CREDIT


ALZA Corporation                                  Letter of Credit No. NZS330632
950 Page Mill Road                          Date: August 13, 1999
Palo Alto, CA 94304
Attention: Senior Vice President & General Counsel

Ladies and Gentlemen:

          At the request and for the account of Chemdex Corporation, 3950 Fabian
Way, Palo Alto, CA 94303, we hereby establish our Irrevocable Letter of Credit
in your favor in the amount of Six Hundred Twenty Five Thousand United States
Dollars (US$625,000.00) available with us at our above office by payment of your
draft(s) drawn on us at sight in the form of Exhibit 1 hereto with the
instructions in brackets therein complied with accompanied by your signed and
dated statement in the form of Exhibit 2 hereto with the instructions in
brackets therein complied with.

          Each drawing must also be accompanied by the original of this Letter
of Credit for our endorsement on this Letter of Credit of our payment of such
drawing.

          Partial and multiple drawings are permitted under this Letter of
Credit, however each drawing must be an amount of not less than US$20,000.00.

          If any instructions accompanying a drawing under this Letter of Credit
request the payment is to be made by transfer to an account with us or at
another bank, we and/or such other bank may rely on an account number specified
in such instructions even if the number identifies a person or entity different
from the intended payee.

          This Letter of Credit expires at our above office on July 31, 2000,
but shall be automatically extended, without written amendment, to July 31 in
each succeeding calendar year up to, but not beyond, April 30, 2005 unless we
have sent written notice to you at your address above by registered mail or
express courier that we elect not to renew this Letter of Credit beyond the date
specified in such notice (the "Non-Renewal Expiration Date"), which Non-Renewal
Expiration Date will be July 31, 2000 or any subsequent July 31 occurring before
April 30, 2005 and be at least 60 calendar days after the date we send you such
notice.

          This Letter of Credit is transferable one or more times, but in each
instance to a single transferee and only in the full amount available to be
drawn under this Letter of Credit at the time of such transfer. Any such
transfer may be effected only through ourselves and only upon presentation to us
at our above-specified office of a duly executed instrument of transfer in the
form attached hereto as Exhibit 3 with the instructions in brackets therein
complied with together with the original of this Letter of Credit. Any transfer
of this Letter of Credit may not change the place of expiration of this Letter
of Credit from our above-specified office. Each transfer shall be evidenced by
our endorsement on the reverse of the original of this Letter of Credit, and we
shall deliver the original of this Letter of Credit so endorsed to the
transferee. All commissions and charges in connection with this transfer are for
the account of Chemdex Corporation.
<PAGE>

                                              Exhibit 3
                                              Wells Fargo Bank, N.A
                                              Letter of Credit No NZS330632

================================================================================

                                              Date: [insert date]

Wells Fargo Bank, N.A.
Trade Services Division, Northern California
525 Market Street, 25th Floor
San Francisco, California 94105
Attention: Manager, Standby Letter of Credit Department

Subject: Your Letter of Credit No. NZS330632

Ladies and Gentlemen:

     For value received, we hereby irrevocably assign and transfer all our
rights under the above-captioned Letter of Credit, as heretofore and hereafter
amended, extended or increased, to:

                          ___________________________
                          [insert Name of Transferee]

                          ___________________________

                          ___________________________
                         [insert Address of Transferee]

     By this transfer, all of our rights in the Letter of Credit are transferred
to the transferee, and the transferee shall have sole rights as beneficiary
under the Letter of Credit, including sole rights relating to any amendments,
whether increases or extensions or other amendments, and whether now existing or
hereafter made. You are hereby irrevocably instructed to advise future
amendment(s) of the Letter of Credit to the transferee without our consent or
notice to us.

     You are hereby advised that [insert Name of Transferee] succeeded to all of
beneficiary's right, title and interest under that certain Office Lease dated
August 13, 1999 (as the same may have been amended to date), with Chemdex
Corporation, a Delaware corporation, as Tenant.

     Enclosed are the original Letter of Credit and the original of all
amendments to this date. Please notify the transferee of this Transfer and of
the terms and conditions of the Letter of Credit as transferred. All fees and
charges in connection with this Transfer are for the account of Chemdex
Corporation

                                             Very truly yours,

                                             [Insert Name of Beneficiary]

                                             By: [insert signature]
                                              Its: [insert title]

Signature of Transferor Guaranteed
[Insert Name of Bank]
By: [insert signature]
Name: [insert typed or printed name]
Title: [insert title

================================================================================

<PAGE>

                                                                   EXHIBIT 10.22

                                 OFFICE LEASE



                                by and between



                               ALZA CORPORATION



                                      and



                              CHEMDEX CORPORATION



                                 for space at



                         1500 and 1550 PLYMOUTH STREET
                           MOUNTAIN VIEW, CALIFORNIA



                                August 13, 1999
<PAGE>

                               TABLE OF CONTENTS

<TABLE>
<S>                                                                                                               <C>
BASIC LEASE PROVISIONS ......................................................................................      1
1.  DEFINITIONS .............................................................................................      2
2.  TERM AND POSSESSION .....................................................................................      5
3.  MONTHLY BASE RENT; NET LEASE ............................................................................      8
4.  LETTER OF CREDIT ........................................................................................      9
5.  TENANT'S PAYMENT OF PROPERTY TAXES AND INSURANCE PREMIUMS ...............................................     10
6.  MAINTENANCE, REPAIR AND REPLACEMENT .....................................................................     12
7.  IMPROVEMENTS AND ALTERATIONS; LIENS .....................................................................     13
8.  USE OF PREMISES .........................................................................................     16
9.  HAZARDOUS MATERIALS .....................................................................................     17
10. UTILITIES AND SERVICES ..................................................................................     20
11. RULES AND REGULATIONS ...................................................................................     21
12. TAXES ON TENANT'S PROPERTY ..............................................................................     21
13. FIRE OR CASUALTY ........................................................................................     22
14. EMINENT DOMAIN ..........................................................................................     23
15. ASSIGNMENT AND SUBLETTING ...............................................................................     25
16. ACCESS AND RESERVED RIGHTS ..............................................................................     29
17. SUBORDINATION AND ATTORNMENT ............................................................................     30
18. TRANSFER OF PREMISES; QUIET ENJOYMENT ...................................................................     31
19. NONLIABILITY AND INDEMNIFICATION OF LANDLORD; INSURANCE .................................................     32
20. WAIVER OF SUBROGATION ...................................................................................     35
21. ATTORNEYS' FEES .........................................................................................     35
22. WAIVER ..................................................................................................     36
23. NOTICES .................................................................................................     36
24. BANKRUPTCY ..............................................................................................     36
25. DEFAULT AND REMEDIES ....................................................................................     37
26. HOLD OVER ...............................................................................................     41
27. CONDITION OF PREMISES ...................................................................................     41
28. QUIET POSSESSION ........................................................................................     41
29. DAMAGE TO TENANT'S PROPERTY .............................................................................     41
30. CONFLICT OF LAWS ........................................................................................     42
31. SUCCESSORS AND ASSIGNS ..................................................................................     42
32. BROKERS .................................................................................................     42
33. NEGOTIATED AGREEMENT ....................................................................................     43
34. INTEREST ON TENANTS OBLIGATIONS; LATE CHARGE ............................................................     43
35. TIME ....................................................................................................     43
36. DEFINED TERMS AND MARGINAL HEADINGS .....................................................................     44
37. PRIOR AGREEMENTS ........................................................................................     44
38. AUTHORITY OF PARTIES ....................................................................................     44
39. NO LIGHT, AIR OR VIEW EASEMENT ..........................................................................     45
40. EXAMINATION OF LEASE ....................................................................................     45
41. FORCE MAJEURE ...........................................................................................     45
42. RECORDING ...............................................................................................     45
43. INCORPORATION BY REFERENCE ..............................................................................     46
</TABLE>
<PAGE>

<TABLE>
<S>                                                                                                               <C>
44. DEFINITION OF ADDITIONAL RENT ................................................................................46
45. SURRENDER OF PREMISES ........................................................................................46
46. NO ACCORD AND SATISFACTION ...................................................................................47
47. MERGER .......................................................................................................47
48. FINANCIAL STATEMENTS .........................................................................................47
</TABLE>

EXHIBITS AND SCHEDULES
- ----------------------

A.       Legal Description
B.       Schedule of Monthly Base Rent
C.       Letter of Credit
D.       Work Letter for Tenant Improvements
E.       Nondisturbance Agreement

1.       List of Remaining Furniture
2.       List of Groundwater Monitoring Report
<PAGE>


                                     LEASE

          THIS LEASE ("Lease") is made this 13/th/ day of August, 1999 by and
between ALZA CORPORATION, a Delaware Corporation ("Landlord"), and CHEMDEX
CORPORATION, a Delaware corporation ("Tenant").

          Landlord hereby leases to Tenant and Tenant hereby hires from
Landlord, subject to all of the terms and conditions hereinafter set forth,
those certain premises described in Item 6 of the Basic Lease Provisions and
located at 1500 and 1550 Plymouth Street, Mountain View, California.

                    BASIC LEASE PROVISIONS
                    ----------------------

1.    Date:         August 13, 1999
      ----

2.    Tenant:       CHEMDEX CORPORATION, a Delaware corporation
      ------

3.    Address:      Before Commencement Date:
      -------

                    3950 Fabian Way
                    Palo Alto, California 94303
                    Attention: Steve Draper, Director of Corporate Operations

                    After Commencement Date:

                    1550 Plymouth Street
                    Mountain View, California 94043
                    Attention: Steve Draper, Director of Corporate Operations

4.    Landlord:     ALZA CORPORATION, a Delaware corporation
      --------

5.    Address:      950 Page Mill Road
      -------
                    Palo Alto, California 94304
                    Attention: Senior Vice President and General Counsel

6.    Premises:     The two-story freestanding building located at 1500 Plymouth
                    Street, Mountain View, California containing approximately
                    40,000 rentable square feet ("RSF") and the two-story
                    freestanding building located at 1550 Plymouth Street,
                    Mountain View, California also containing approximately
                    40,000 RSF, together with the parking areas, driveways,
                    landscaping, common areas and other appurtenances
                    constructed or located on or serving the 1500 and 1550
                    Plymouth Street buildings (the "Premises"). The real
                    property on which the Premises is located is more
                    particularly described in Exhibit A attached hereto and
                                              ---------
                    incorporated herein by this reference
<PAGE>

7.    Term:               Approximately five (5) years and four (4) months (See
      ----
                          Article 2)

8.    Monthly Base Rent:  The following Monthly Base Rent for the
      -----------------
                          Premises shall be payable on a triple net basis
                          pursuant to Section 3.1 below: From the Commencement
                          Date until October 14, 2000, Two Hundred Twenty-Eight
                          Thousand Dollars ($228,000) per month. The Monthly
                          Base Rent for the remaining Lease years during the
                          Term and each Extended Term (if any) of this Lease
                          shall be as set forth on Exhibit B attached hereto and
                                                   ---------
                          incorporated herein by this reference. Monthly Base
                          Rent for the Premises (but no other rent or charges
                          due under this Lease) shall be forgiven for the first
                          month of the Term.

9.    Prepaid Rent:       $228,000 due upon execution of the Lease by Landlord
      ------------
                          and Tenant (See Section 3.1)

10.   Letter of Credit:   Letter of Credit in the amount of One Million Eight
      ----------------
                          Hundred Seventy-Five Thousand Dollars ($1,875,000) due
                          upon execution of the Lease (See Article 4)

11.   Permitted Use:      As provided in Article 8
      -------------

12.   Renewal Options:    Subject to Landlord's Recapture Right (defined in
      ---------------
                          Section 2.3 below), two (2) successive one (1) year
                          renewal options (See Section 2.3)

13.   Expansion Options:  None
      ------------------

14.   Landlord's Broker:  Catalyst-CRESA Real Estate Group
      -----------------

15.   Tenant's Broker:    Cornish & Carey Commercial Real Estate
      ---------------

          The foregoing Basic Lease Provisions set forth the essential terms of
this Lease and should be read in conjunction with the rest of the Lease and in
particular, with reference to how those terms are defined in the Lease.

                                   ARTICLE 1

                                  DEFINITIONS
                                  -----------

          Unless otherwise specified, the following terms used in this Lease and
designated by initial capitals shall have the following meanings:

     1.1  "Environmental Laws" shall mean all local, state, or federal laws,
           ------------------
statutes, ordinances, rules, regulations, judgments, injunctions, stipulations,
decrees, orders, policies, permits, approvals, treaties, or protocols now or
hereafter enacted, issued or promulgated by any governmental authority which
relate to any Hazardous Material or the use, manufacture, handling, treatment,
transportation, production, disposal, discharge, distribution, release,
recycling, emission, sale, or storage of, or the exposure of any person to, a
Hazardous Material.
<PAGE>

     1.2  "Financial Statements" shall mean the financial information contained
           --------------------
in Tenant's Initial Registration Statement on Form S-1 accessed by Landlord on
or about May 24, 1999 at www.freeedgar.com.

     1.3  "Force Majeure" shall mean any of the events described in Article 41,
           -------------
below.

     1.4  "Hazardous Material" shall mean any material or substance that is now
           ------------------
or hereafter prohibited or regulated by any statute, law, rule, regulation or
ordinance or that is now or hereafter designated by any governmental authority
to be radioactive, toxic, hazardous or otherwise a danger to health,
reproduction or the environment including but not limited to (i) oil and
petroleum products, (ii) radioactive materials, (iii) asbestos and asbestos-
containing materials, (iv) polycholorinated biphenyls, and (v) viruses, microbes
and other biological materials and (v) substances defined as "hazardous
substances", "hazardous materials", or "toxic substances" in the Comprehensive
Environmental Response Compensation and Liability Act of 1980, as amended, 42
U.S.C. (S)(S)9601 et seq.; the Hazardous Materials Transportation Act, 49 U.S.C.
                  -- ---
(S)(S) 1801 et seq.; the Resource Conservation and Recovery Act, 42 U.S.C.
            -- ---
(S)(S) 6901, et seq.; the Toxic Substances Control Act, 15 U.S.C. (S)(S) 2601,
             -- ---
et seq.; the Clean Water Act, 33 U.S.C. (S)(S) 1251, et seq.; the California
- -- ---                                               -- ---
Hazardous Waste Control Act, Health and Safety Code (S)(S) 25330, et seq.; the
                                                                  -- ---
California Safe Drinking Water and Toxic Enforcement Act, Health and Safety Code
(S)(S) 25249.5, et seq.; California Health and Safety Code (S)(S) 25280, et seq.
                -- ---                                                   -- ---
(Underground Storage of Hazardous Substances); the California Hazardous Waste
Management Act, Health and Safety Code, (S)(S) 25170, et seq. (Hazardous
                                                      -- ---
Materials Release Response Plans and Inventory); the California Porter-Cologne
Water Quality Control Act, Water Code (S)(S) 13000, et seq.; all as amended.
                                                    -- ---

     1.5  "Hazardous Material Condition" shall mean the occurrence or discovery,
           ----------------------------
after the Commencement Date, of a condition involving the presence of, or a
contamination by, a Hazardous Material in or under the Premises requiring
remediation under Environmental Laws or rendering any part of the Premises
unsafe for human occupancy.

     1.6  "Joaquin Lease" shall mean the office lease of even date herewith
           -------------
executed by Landlord and Tenant for the Joaquin Premises.

     1.7  "Joaquin Premises" shall mean the second floor of the two-story
           ----------------
freestanding building located at 1010 Joaquin Road, Mountain View, California,
containing approximately 26,445 RSF together with the shared parking areas,
driveways, landscaping, common areas and other appurtenances constructed or
located thereon.

     1.8  "Landlord Affiliate" shall mean any corporation, general or limited
           ------------------
partnership, joint venture, limited liability company or other person or entity
which controls, is controlled by or under common control with ALZA Corporation
or resulting from a merger or consolidation with ALZA Corporation or which
acquires substantially all of the assets of ALZA Corporation.

     1.9  "Landlord Parties" shall mean Landlord, its employees, agents,
           ----------------
consultants, licensees, invitees, contractors, subcontractors, and any other
person for whom Landlord is legally responsible, provided that under no
circumstances shall any of Tenant Parties be deemed a Landlord Party for
purposes of this Lease.
<PAGE>

     1.10  "Lease" shall mean this Lease document including the Basic Lease
            -----
Provisions and any and all Exhibits and Adgenda attached hereto now or in the
future.

     1.11  "Letter of Credit" shall mean the Letter of Credit described in
            ----------------
Article 4 below.

     1.12  "Permitted Use" shall mean the sole use for which Tenant may utilize
            -------------
the Premises as specified in Item 11 of the Basic Lease Provisions and Article 8
below.

     1.13  "Premises" shall have the meaning set forth in Item 6 of the Basic
            --------
Lease Provisions.

     1.14  "Rent" and "rent" shall mean Monthly Base Rent, Additional Rent and
            ----
all other charges payable hereunder and under any Exhibit or Adgenda to this
Lease, and any other monetary obligations of Tenant to Landlord under the
provisions of this Lease.

     1.15  "Technology Party" shall mean any corporation, general or limited
            ----------------
partnership, joint venture, limited liability company or other person or entity
which is pursuing the application of Landlord's technology as a material part of
its business pursuant to a written agreement with Landlord.

     1.16  "Tenant Affiliate" shall mean any corporation, general or limited
            ----------------
partnership, joint venture, limited liability company or other person or entity
(collectively, "person") which satisfies each of the following three criteria:
(i) such person controls, is controlled by or is under common control with
Tenant or results from a merger or consolidation with Tenant; (ii) Tenant
beneficially owns more than fifty percent (50%) of such person; and (iii) such
person has a net worth, determined in accordance with generally accepted
accounting principles ("GAAP"), in excess of Twenty Million Dollars
($20,000,000).

     1.17  "Tenant Subsidiary" shall mean any corporation, general or limited
            -----------------
partnership, joint venture, limited liability company or other person or entity
(collectively, "person") which satisfies each of the following two criteria: (i)
such person controls, is controlled by or is under common control with Tenant or
results from a merger or consolidation with Tenant; and (ii) Tenant beneficially
owns more than fifty percent (50%) of such person.

     1.18  "Tenant Parties" shall mean Tenant, its employees, agents,
            --------------
consultants, licensees, invitees, contractors, subcontractors, and any other
person for whom Tenant is legally responsible, provided that under no
circumstances shall any of Landlord Parties be deemed a Tenant Party for
purposed of this Lease.

     1.19  "Term" shall mean the period of the Lease between the Commencement
            ----
Date and the Expiration Date (as such Commencement Date and Expiration Date are
defined in Section 2.1 below) or earlier termination of the Lease, but not to
exceed the period set forth in Item 7 of the Basic Lease Provisions unless
extended as provided in Section 2.3 below.

     1.20  Other defined terms used in this Lease shall have the meanings set
forth in the Lease, including the following:

           1.20.1  "Additional Rent" is defined in Article 44;
                    ---------------
<PAGE>

          1.20.2  "Commencement Date" is defined in Section 2.1;
                   -----------------

          1.20.3  "Expiration Date" is defined in Section 2.1; and
                   ---------------

          1.20.4  "Monthly Base Rent" is defined in Article 3.
                   -----------------

                                   ARTICLE 2

                              TERM AND POSSESSION
                              -------------------

     2.1  Commencement. The Term of this Lease shall be for approximately five
          ------------
(5) years and four (4) months as described in Item 7 of the Basic Lease
Provisions and shall commence on that date when Landlord delivers possession of
the Premises to Tenant in vacant, broom-clean condition, which Landlord
anticipates to occur on or about October 15, 1999 (the "Commencement Date"), and
shall expire on February 28, 2005 (the "Expiration Date"). Landlord shall
exercise commercially reasonable efforts (subject to Force Majeure delays) to
deliver the Premises to Tenant on or about October 15, 1999. Landlord shall
exercise commercially reasonable efforts to give Tenant at least thirty (30)
days prior written notice of each anticipated Commencement Date (but without any
liability on Landlord's part if Landlord shall fail to do so). Landlord and
Tenant shall execute a letter agreement confirming each exact Commencement Date
within five (5) business days following the Commencement Date. If the
Commencement Date and delivery of possession of the Premises to Tenant does not
occur on or before December 15, 1999, then Tenant's sole and exclusive remedy
with respect to such delay in the Commencement Date shall be to terminate this
Lease and the Joaquin Lease by written notice given to Landlord on or before
December 31, 1999, and in the event of such termination both Landlord and Tenant
shall be released and relieved of their respective obligations and liabilities
under this Lease and under the Joaquin Lease, Landlord shall return Tenant's
prepaid rent and the Letter of Credit paid or delivered by Tenant under this
Lease and under the Joaquin Lease to Tenant and neither party shall have any
right to recover any losses, costs, expenses or damages (including, without
limitation, loss of profits, foreseeable or unforeseeable consequential damages
or special damages) from the other party.

     2.2  Tenant's Acceptance of Possession. Tenant acknowledges and agrees that
          ---------------------------------
(i) Tenant has made all investigations which Tenant deems necessary concerning
(A) the condition of the Premises including the soil, air and groundwater
thereof, (B) Landlord's prior use of the Premises, (C) the adequacy of parking
for Tenant's intended office use of the Premises, (D) the compliance of the
Premises with all applicable statutes, laws, ordinances and regulations and (E)
Tenant's ability to operate its business in the Premises, (ii) Tenant shall
accept the Premises in "AS IS" and "WITH ALL FAULTS" condition on the
Commencement Date subject to all applicable zoning, municipal, county, state and
federal statutes, laws, ordinances and regulations governing and regulating the
use of the Premises and all easements, encumbrances, covenants, conditions and
restrictions of record, (iii) except as otherwise provided in this Lease,
Landlord has no obligation to alter or improve the Premises of any nature
whatsoever and (iv) Tenant acknowledges and agrees that neither Landlord nor any
of its agents or representatives has made any oral or written representations or
warranties of any nature whatsoever (a) with respect to the Premises including
the soil, air and groundwater thereof, (b) compliance or the Premises with
<PAGE>

building codes and applicable laws, (c) the ability of Tenant to operate its
business in the Premises or (d) as to any of the matters set forth in subclauses
(i)(A) through (i)(E) above.

     2.3  Option To Extend Term. Landlord shall notify Tenant in writing at
          ---------------------
least twelve (12) months prior to the Expiration Date of the initial Term of the
Lease and/or twelve (12) months prior to the expiration of the first Extended
Term (defined below), as applicable, as to whether Landlord will exercise its
right to repossess one or both of the buildings comprising the Premises (with
any such repossessed Premises being referred to herein as the "Repossessed
Premises") from and after the Expiration Date or the expiration of the first
Extended Term, as applicable (the "Recapture Right"). If Landlord, in Landlord's
sole and absolute discretion, exercises this Recapture Right, then (i) the Lease
shall terminate on the Expiration Date or the expiration of the first Extended
Term, as applicable, as to the Repossessed Premises, (ii) Tenant shall have no
right to extend this Lease for the Extended Term(s) (defined below) as to such
Repossessed Premises, (iii) from and after the Expiration Date or the expiration
of the first Extended Term, as applicable, Tenant shall have no further rights
or interests in the Repossessed Premises of any nature whatsoever, and (iv)
provided Landlord, a Landlord Affiliate and/or a Technology Party initially
occupies more than fifty percent (50%) of the Repossessed Premises for their own
use, Landlord shall be free to use the balance of the Repossessed Premises for
any purposes whatsoever, including, without limitation, assigning or subleasing
the balance of the Repossessed Premises to any person or entity for any purpose
whatsoever. If Landlord does not timely exercise its Recapture Right as to all
or any portion of the Premises upon the Expiration Date or the expiration of the
first Extended Term, as applicable, then Tenant shall have the option to extend
the term of this Lease solely as to that portion of the Premises (but not less
than an entire building) which is not Repossessed Premises for two (2) extended
term(s) of one (1) year each commencing upon the Expiration Date of the initial
Term of the Lease and the expiration of the first one-year Extended Term (each,
an "Extended Term"). Tenant may exercise the foregoing option to extend if and
only if (i) Tenant notifies Landlord in writing of its irrevocable election to
extend the Term of the Lease for the Extended Term no later than eleven (11)
months prior to the Expiration Date of the initial Term of the Lease or eleven
(11) months prior to the expiration date of the first one-year Extended Term, as
applicable, (ii) Tenant extends the term with respect to an entire building (and
not solely a portion of a building) and (iii) Tenant is not in material default
of the Lease (following the expiration of any applicable cure periods without
cure) either at the time of giving notice of its irrevocable election to extend
or on the commencement date of each Extended Term. If each of the conditions set
forth in the immediately preceding sentence are not satisfied in full, then
Tenant's option(s) to extend the term of the Lease shall lapse and be null and
void and the terms and provisions of the second sentence of this Section 2.3
shall apply as though Landlord had exercised its Recapture Right as to all of
the Premises. All of the terms and provisions of this Lease shall apply during
the Extended Term(s) except that (a) if Tenant extends the Lease as to less than
the entire Premises, Rent and the Face Amount of the Letter of Credit shall be
equitably reduced to reflect the reduction in square footage of the portion of
the Premises to be leased by Tenant during the Extended Term(s), (b) there shall
be no further right to extend the term of the Lease beyond the second Extended
Term, (c) except as expressly provided in this Lease, Landlord shall have no
obligation to make improvements to the Premises of any nature whatsoever, (d)
Tenant shall not be entitled to any abatement of Monthly Base Rent during either
Extended Term and (e) Monthly Base Rent during each the Extended Term shall be
determined and annually increased in accordance with the provisions of Exhibit B
                                                                       ---------
attached hereto. The foregoing right to extend the

                                      -6-
<PAGE>

term of the Lease is personal to Tenant and may not be assigned, sold, leased or
otherwise transferred, voluntarily or involuntarily, by or to any other person
or entity except to a Tenant Affiliate in accordance with Article 15 below.

     2.4  HVAC Inspection. Prior to the Commencement Date, Landlord, at
          ---------------
Landlord's sole cost, shall cause a duly licensed heating, ventilating and air
conditioning ("HVAC") service and repair specialist to inspect the entire HVAC
system within the Premises, repair any deficiencies within such HVAC system and
certify in writing that the HVAC system is in good working order and repair.

     2.5  Limited Early Access. Tenant, MCIWorldcom-Brooks Fiber, and its
          --------------------
subcontractors (collectively, "Early Access Parties") may enter upon the
Premises prior to the Commencement Date, at such times and places requested by
Tenant and approved by Landlord (such approval not to be unreasonably withheld
or delayed), for the sole purpose of allowing Tenant and/or any other Early
Access Party (a) to connect Tenant's telecommunications lines (including data,
voice and video cabling and wiring) to the exterior of the 1500 Plymouth
building and the 1550 Plymouth building, and (b) to install and test Tenant's
telecommunications equipment and systems (including data, voice and video
equipment and systems) within said buildings. In connection with each such entry
upon the Premises by an Early Access Party, each Early Access Party shall use
all reasonable efforts to ensure that the business of Landlord shall be
interfered with and inconvenienced as little as is reasonably practicable under
the circumstances and shall otherwise fully comply with Section 7.3 of the Lease
in all respects, which Section shall apply to each entry upon the Premises by an
Early Access Party pursuant hereto; provided, however, that an Early Access
Party shall only be required to give Landlord not less than ten (10) calendar
days prior notice for entries that contemplate work that is physically intrusive
(such as trenching and boring or drilling into the parking lot, ground, or walls
of the 1500 and 1550 Plymouth buildings) and not less than five (5) calendar
days prior notice for entries that contemplate work that is not physically
intrusive. Notwithstanding the foregoing, (i) Landlord may assign a security
guard to accompany each Early Access Party while on the Premises pursuant to
this Section 2.5 and (ii) any drilling by an Early Access Party into the hard
walls of the 1500 and 1550 Plymouth buildings shall, unless otherwise agreed to
by Landlord, take place after 5:00 p.m. California time on work days or at any
reasonable time on weekend days. Further, the provisions of Article 20 and
Sections 19.1, 19.2, 19.3.1, 19.3.2, 19.5, 19.6 and 19.7 of the Lease shall
apply and be in full force and effect during each entry upon the Premises by any
Early Access Party pursuant to this Section 2.5. Prior to and as a condition to
each such entry by an Early Access Party, Tenant shall furnish Landlord with
proof of the insurance required of Tenant under Sections 19.3.1, 19.3.2 and 19.6
of this Lease. Tenant agrees to defend, indemnify and save harmless Landlord its
officers, directors, employees, affiliates, subsidiaries, shareholders, lenders,
successors and assigns from all liabilities, costs, damages, fees, liens and
expenses suffered or incurred by them as a result of any activity, work or thing
done on or about the Premises by Tenant and/or any other Early Access Party
pursuant to this Section 2.5. Notwithstanding Tenant's rights under this Section
2.5, Tenant's obligation to pay Monthly Base Rent and Additional Rent shall not
commence until the Commencement Date.

                                      -7-
<PAGE>

                                   ARTICLE 3

                          MONTHLY BASE RENT; NET LEASE
                          ----------------------------

     3.1  Monthly Base Rent. Tenant shall pay to Landlord as Monthly Base Rent
          -----------------
for the Premises the sum(s) described in Item 8 of the Basic Lease Provisions
and as set forth on Exhibit B to this Lease during the entire Term and any
                    ---------
Extended Term(s). The Monthly Base Rent shall be payable in advance on the first
day of each calendar month, without deduction, setoff, abatement, prior notice
or demand, commencing on the Commencement Date and continuing for each calendar
month thereafter during the Term of the Lease and the Extended Term(s), if
applicable. In the event the Term of this Lease commences or ends on a day other
than the first or last day of a calendar month, then the Monthly Base Rent for
such partial month shall be prorated in the proportion that the number of days
this Lease is in effect during such partial month bears to the number of days in
that calendar month, and such Monthly Base Rent shall be paid at the
commencement of such partial month. Monthly Base Rent shall be payable in lawful
money of the United States at the address of Landlord set forth in Item 5 of the
Basic Lease Provisions or at such other address as may be designated by Landlord
in writing pursuant to Article 23 below. Notwithstanding any other term of this
Lease to the contrary, a prepayment of Monthly Base Rent in the amount set forth
in Item 9 of the Basic Lease Provisions shall be made by Tenant upon execution
of this Lease and shall be applied to the Monthly Base Rent for the second (2nd)
full calendar month of the Term. Landlord hereby acknowledges receipt of such
prepaid rent from Tenant.

     3.2  Forgiveness of Monthly Base Rent. As an inducement to Tenant to enter
          --------------------------------
into this Lease, Tenant shall be entitled to unconditional forgiveness of
Monthly Base Rent in the amount of $228,000 for the first (lst) month of the
Term ("Forgiven Rent"). There shall be no abatement of Monthly Base Rent during
either Extended Term of this Lease. Tenant's obligation to pay in full all
Additional Rent and all other charges payable under this Lease shall not be
affected by the foregoing Forgiven Rent.

     3.3  Additional Rent. In addition to the Monthly Base Rent reserved in
          ---------------
Section 3.1 above, Tenant shall reimburse to Landlord or pay to the parties
entitled thereto, as applicable, all impositions, Insurance Premiums (as defined
in Section 5.3 below), Property Taxes (as defined in Section 5.2 below),
operating charges, maintenance charges, construction costs, and any other
charges, costs and expenses which arise or may be contemplated under any
provisions of this Lease during the Term hereof and each Extended Term on the
terms set forth in this Lease. All of such charges, costs and expenses shall
constitute Additional Rent, and upon the failure of Tenant to timely reimburse
or pay any of such costs, charges or expenses, Landlord shall have the same
rights and remedies as otherwise provided in this Lease for the failure of
Tenant to pay rent. It is the intention of the parties hereto that this Lease
shall not be terminable for any reason by Tenant except for Landlord's uncured
material breach of this Lease as provided in Section 25.3 below and except as
otherwise expressly provided herein and that Tenant shall in no event be
entitled to any abatement of or reduction in Rent payable under this Lease
except as herein expressly provided. Any present or future law to the contrary
shall not alter this agreement of the parties.

                                      -8-
<PAGE>

                                   ARTICLE 4

                                LETTER OF CREDIT
                                ----------------

     4.1  Letter of Credit as Security. Concurrent with the execution of this
          ----------------------------
Lease, Tenant shall deliver to Landlord the Letter of Credit (as defined in
Section 4.2 below) in the amount of One Million Eight Hundred Seventy-Five
Thousand Dollars ($1,875,000), which Letter of Credit shall secure the full and
faithful performance of each and every provision and condition of this Lease to
be performed by Tenant. The amount of the Letter of Credit shall be reduced to
Seven Hundred Fifty Thousand Dollars ($750,000) on February 1, 2002 if Tenant's
net worth on such date (determined in accordance with generally accepted
accounting principals ("GAAP")) exceeds Twenty Million Dollars ($20,000,000) and
(ii) the amount of the Letter of Credit shall be further reduced to Three
Hundred Seventy-Five Thousand Dollars ($375,000) on February 1, 2003 if Tenant's
net worth on such date (determined in accordance with GAAP) continues to exceed
Twenty Million Dollars ($20,000,000). There shall be no further reduction in the
stated amount of the Letter of Credit from and after February 1, 2003. The face
amount of the Letter of Credit (as reduced above from time to time upon
satisfaction of the foregoing conditions) is hereafter referred to as the "Face
Amount". Anything contained in this Article 4 to the contrary notwithstanding,
the Face Amount of the Letter of Credit shall not be reduced if Tenant has
previously committed an uncured default under this Lease. If an Event of Default
occurs under this Lease (including but not limited to an Event of Default with
respect to the obligation to pay Rent or to clean and restore the Premises upon
termination of the Lease), Landlord may, but shall not be required to, draw upon
the Letter of Credit for the payment of any Rent, interest, late charges or any
other sum in default, or for the payment of any other amount which Landlord may
spend or become obligated to spend by reason of the Event of Default or to
compensate Landlord for any other loss or damage which Landlord may suffer by
reason of the Event of Default, including, without limitation, costs and
reasonable attorneys' fees incurred by Landlord to collect on the Letter of
Credit and/or to recover possession of the Premises following an Event of
Default by Tenant hereunder. Tenant shall cause the Letter of Credit to remain
in effect during the entire Term of this Lease and for an additional period of
sixty (60) days following the expiration or earlier termination of this Lease.
If Tenant fails to maintain, renew or replace the Letter of Credit in its then
Face Amount at least thirty (30) days before its stated expiration date (or if
Tenant fails to maintain, renew or replace the letter of credit under Article 4
of the Joaquin Lease in its then face amount at least thirty (30) days before
its stated expiration date), then Landlord may, without prejudice to any other
right or remedy, draw upon the entire amount of the Letter of Credit. Any amount
drawn by Landlord on the Letter of Credit pursuant to this Section 4.1 but not
applied by Landlord to satisfy Tenant's obligations hereunder shall be held by
Landlord as a security deposit. Landlord may commingle any proceeds from the
Letter of Credit with Landlord's general funds and Tenant shall not be entitled
to any interest thereon. If Landlord draws on any portion of the Letter of
Credit, Tenant shall, within three (3) business days after demand by Landlord,
either (a) deposit immediately available funds with Landlord in the amount that
when added to the remaining amount of the undrawn portion of the Letter of
Credit equals its then Face Amount or (b) deliver to Landlord written
documentation acceptable to Landlord executed by the Issuing Bank (as defined in
Section 4.2 below) confirming that the Issuing Bank has reinstated the Letter of
Credit to its then full Face Amount; and Tenant's failure to do either (a) or
(b) above shall constitute an Event of Default hereunder. If the funds received
by Landlord pursuant to a draw on the Letter of Credit exceed the amount applied
by Landlord to

                                      -9-
<PAGE>

cure the Event of Default, concurrently with and conditioned upon Tenant's
reinstatement of the Letter of Credit to its full Face Amount, Landlord shall
return any such excess funds to Tenant. If Tenant shall fully perform each and
every provision of this Lease required by Tenant to be performed, the Letter of
Credit (and any funds held by Landlord as a security deposit after drawing on
the Letter of Credit) shall be returned to Tenant (or, at Landlord's option, to
the last assignee of Tenant's interest hereunder) within sixty (60) days
following the later of the expiration of the Term or surrender of possession of
the Premises to Landlord. Notwithstanding the foregoing, the Letter of Credit
(and any funds held by Landlord as a security deposit after drawing on the
Letter of Credit) shall be immediately returned to Tenant upon the termination
of this Lease solely by reason of Landlord's material default hereunder. Tenant
shall not assign or encumber the Letter of Credit. Any attempt to do so shall be
void and Landlord shall not be bound by any such purported assignment or
encumbrance. In the event of bankruptcy or other insolvency proceedings filed by
or against Tenant, all sums drawn under the Letter of Credit shall be deemed to
be applied first to the payment of Rent and other charges due Landlord for all
periods prior to the effective date of such proceedings. If Landlord transfers
or assigns its interest in the Premises, Landlord may transfer or assign the
Letter of Credit to such transferee.

     4.2  Form of Letter of Credit. Concurrent with the execution of this Lease,
          ------------------------
Tenant shall deliver to Landlord an irrevocable, unconditional standby letter of
credit in the original face amount of One Million Eight Hundred Seventy-Five
Thousand Dollars ($1,875,000) in the form attached hereto as Exhibit C (the
                                                             ---------
"Letter of Credit") to secure the full and faithful performance of each and
every term and provision of this Lease to be performed by Tenant as set forth in
Section 4.1 above. The Letter of Credit shall be issued by a bank or financial
institution ("Issuing Bank") which is acceptable to Landlord and which accepts
deposits, maintains accounts, is FDIC insured and has a local Mountain View or
San Francisco office which will negotiate the Letter of Credit. The Letter of
Credit shall permit full or partial draws by Landlord or Landlord's assignee.
Tenant shall pay all expenses, points or fees incurred by Tenant in obtaining,
maintaining and renewing the Letter of Credit. As provided in Section 4.1 above,
Tenant shall cause the Letter of Credit to remain in full force and effect
during the entire term of this Lease and for a period of sixty (60) days
following the expiration or earlier termination of this Lease (except in the
case of termination of this Lease solely by reason of Landlord's material
default hereunder). Provided this Lease has not expired or terminated, Tenant
shall replace or renew the Letter of Credit from time to time at least thirty
(30) days before its stated expiration date. Failure to so replace or renew the
Letter of Credit shall constitute a default hereunder and Landlord shall
thereafter be entitled to draw the full amount of the Letter of Credit and hold
it as a cash security deposit. The terms of the Letter of Credit shall expressly
provide that the Letter of Credit is assignable by Landlord, as beneficiary
thereunder, to any transferee or assignee of Landlord's interest in the Premises
who expressly assumes in writing Landlord's obligations under this Lease.

                                   ARTICLE 5

                       TENANT'S PAYMENT OF PROPERTY TAXES
                             AND INSURANCE PREMIUMS
                             ----------------------

     5.1  Payment of Property Taxes and Insurance Premiums. In addition to
          ------------------------------------------------
payment of Monthly Base Rent pursuant to Section 3.1 above, Tenant shall
reimburse on the terms set forth

                                      -10-
<PAGE>

in this Article 5 to Landlord, as part of Additional Rent hereunder, Property
Taxes (as defined in Section 5.2 below) and Insurance Premiums (as defined in
Section 5.3 below). Tenant shall reimburse Landlord for all Property Taxes paid
by Landlord for the Premises within ten (10) business days following Tenant's
receipt from Landlord of written demand for reimbursement of such Property Taxes
accompanied by a copy of the then applicable tax bill and a copy of Landlord's
check made payable to the taxing authority. Tenant shall likewise reimburse
Landlord for all Insurance Premiums paid by Landlord for the Premises within ten
(10) business days following Tenant's receipt from Landlord of written demand
for reimbursement of such Insurance Premiums accompanied by a copy of the
applicable insurance premium invoice and a copy of Landlord's check made payable
to the insurance carrier. If any Property Taxes or Insurance Premiums so paid by
Landlord cover any period of time prior to or after the expiration of the Term
hereof, Tenant's share of Property Taxes or Insurance Premiums shall be
equitably prorated to reflect only the period of time during which the Lease was
in effect.

     5.2  Property Taxes Defined. The term "Property Taxes" as used herein shall
          ----------------------
mean and include (i) any and all real estate and personal property taxes and
other taxes, rates, charges, general and special assessments, transit charges,
housing fund assessments, liens, assessment bonds, district formation costs,
bonds, levies, fees and impositions whether general, special or supplemental,
unforeseen or foreseen, ordinary or extraordinary which are assessed, imposed,
charged, confirmed or levied with respect to the Premises, and/or any
improvements, fixtures and equipment and other property of Landlord, real or
personal, located thereon, but only to the extent each of the foregoing relates
to the period between the Commencement Date (as applicable) and the date this
Lease expires or sooner terminates and any costs, fees or expenses incurred in
contesting the amount or validity of any of the foregoing; (ii) any tax,
surcharge, levy, fee or assessment which may be imposed in addition to or in
lieu of real estate or personal property taxes against the Premises, but only to
the extent each of the foregoing relates to the period between the Commencement
Date (as applicable) and the date this Lease expires or sooner terminates; and
(iii) any service, use or other fee collected by governmental agencies in
addition to or in lieu of real estate or personal property taxes against the
Premises for services provided by such agencies, but only to the extent each of
the foregoing relates to the period between the Commencement Date (as
applicable) and the date this Lease expires or sooner terminates. The term
Property Taxes as used herein shall also include any new, replacement or
supplemental property taxes and any rental, excise, sales, mortgage, transaction
privilege, or other tax or levy, however denominated, imposed upon or measured
by the rental reserved hereunder or on Landlord's business of owning, operating
or leasing the Premises, but only to the extent each of the foregoing relates to
the period between the Commencement Date (as applicable) and the date this Lease
expires or sooner terminates. However, notwithstanding anything to the contrary
above or elsewhere in this Lease, the term "Property Taxes" shall not mean or
include (a) any income, franchise, capital stock, estate or inheritance taxes of
or applicable to Landlord or (b) any transfer taxes. Property Taxes shall also
include all increases in Property Taxes during the Term or Extended Term
including, without limitation, (a) annual increases, (b) increases due to a
reassessment of the Premises arising from a change in ownership or transfer of
all or part of Landlord's interest in the Lease, or the Premises or any
refinancing of the Premises or (c) any new construction, alterations or
renovations to the Premises. If any Property Taxes shall be payable in
installments over a period of time extending beyond the Term of the Lease (or
the Extended Term, if applicable), Tenant shall only be required to pay such
installments thereof as shall become due and payable during, or relate to
periods of time covered

                                      -11-
<PAGE>

by, the Term of the Lease (or any Extended Term, if applicable). Landlord shall
provide Tenant with a copy of its annual Property Tax statements.

     5.3  Insurance Premiums. The term "Insurance Premiums" shall mean and
          ------------------
include all premiums paid or incurred by Landlord in obtaining and maintaining
the insurance coverages required to be maintained by Landlord under Section 19.4
below and other commercially reasonable insurance coverages which Landlord
acting as a prudent landowner and landlord may obtain and maintain, but only to
the extent such premiums paid for insurance coverage relate to the period
between the Commencement Date (as applicable) and the expiration or sooner
termination of this Lease.

                                   ARTICLE 6

                      MAINTENANCE, REPAIR AND REPLACEMENT
                      -----------------------------------

     6.1  Tenant's Obligations for the Premises. Except for the obligations of
          -------------------------------------
Landlord under Article 13 (relating to the destruction of the Premises), Article
14 (relating to condemnation of the Premises) and Sections 6.3 and 9.2 hereof,
and except for damage caused by Landlord or the Landlord Parties (which shall be
the sole and exclusive responsibility and cost of Landlord), Tenant, at Tenant's
sole cost and expense, shall keep in good and neat order, condition and repair
the Premises and every part thereof, structural and non-structural, whether or
not capital in nature (and whether or not the portion of the Premises requiring
repair or replacement, or the means of repairing or replacing the same are
reasonably accessible to Tenant, and whether or not the need for repairs,
replacements and/or capital improvements occurs as a result of Tenant's use, any
prior use, the elements or age of such portion of the Premises, or alterations,
additions, repairs or replacements required by governmental authority, whether
or not related to Tenant's specific use of the Premises) including, without
limitation, repair and replacement (including any and all replacements and
capital improvements) of all plumbing, electrical, heating, ventilating and air
conditioning systems, all elevators, stairways and stairwells, all sprinkler and
life safety systems, wiring and equipment within the Premises, all fixtures,
interior and exterior non-bearing walls, ceilings, floors, windows, doors, plate
glass, and all landscaping, landscaping and irrigation systems, driveways,
parking lots, loading docks, fences and signs located on the Premises and all
sidewalks and pathways located on the Premises; provided, however, that the cost
of any capital improvements or replacements having a useful life (as determined
in accordance with GAAP) longer than the Lease Term (including the Extended
Term(s), if any), shall be amortized over such useful life and Tenant shall only
be obligated to pay, each month during the remainder of the Term (and Extended
Term(s), if any), on the date on which Base Monthly Rent is due, an amount equal
to the product obtained by multiplying the cost of such capital improvement or
replacement by a fraction, the numerator of which is one, and the denominator of
which is the number of months of the useful life of such capital improvement or
replacement (as such useful life is determined in accordance with GAAP), with
Tenant reserving the right to prepay its obligation at any time. Within ten (10)
business days after written demand from Tenant, Landlord shall reimburse Tenant
in full for the cost of any capital improvements or replacements made to the
Premises by Tenant pursuant to this Section 6.1. Tenant, at Tenant's sole
expense, shall procure and maintain during the Term a maintenance contract with
a contractor specializing in and experienced in maintenance and service of the
heating, ventilating and air conditioning systems for the Premises, which

                                      -12-
<PAGE>

maintenance contract and contractor shall be reasonably acceptable to Landlord.
Prior to the Commencement Date, Landlord shall exercise reasonable efforts to
have its landscaping and janitorial vendors enter into service agreements with
Tenant to provide services to Tenant which are comparable to the services which
they previously provided to Landlord at the Premises at rates comparable to
those which they charge Landlord.

     6.2  Landlord's Rights. If an Event of Default involving Tenant's failure
          -----------------
to perform Tenant's obligations under Section 6.1 above or under any other
Section of this Lease should occur, Landlord may at its option (but shall not be
required to) enter upon the Premises upon ten (10) business days prior written
notice to Tenant (except in an emergency, in which case no notice shall be
required) to cure such Event of Default on Tenant's behalf, and all reasonable
costs thereof together with interest thereon as set forth in Section 34.1 below
shall constitute Additional Rent hereunder and shall be due and payable within
five (5) business days after written demand by Landlord. Notwithstanding the
foregoing, in the case of an emergency resulting from Tenant's failure to
perform its obligations under Section 6.1 above or under any other Section of
this Lease, Landlord may act immediately pursuant to this Section 6.2

     6.3  Landlord's Obligations for the Premises. Except for the obligations of
          ---------------------------------------
Landlord under this Section 6.3, Section 9.2, Article 13 and Article 14 below,
and except for damage caused by Tenant or the Tenant Parties (which shall be the
sole and exclusive responsibility and cost of Tenant), Tenant acknowledges and
agrees that Landlord shall have no obligation, in any manner whatsoever, to
repair or maintain the Premises, whether structural or nonstructural. Landlord
shall, at its sole cost and expense keep in good and neat order, condition and
repair, the roof and roof membrane at the Premises, the skylights at the
Premises, the foundation for the Premises, and the structural walls (including,
without limitation, interior and exterior bearing walls) at the Premises,
whether or not capital in nature, including, without limitation, repair and
replacement (including any and all replacements and capital improvements) of the
foregoing items.

     6.4  Waivers. Except as expressly provided in Articles 13 and 14 below,
          -------
there shall be no abatement of Rent and no liability of Landlord by reason of
any injury to or interference with Tenant's business arising from Tenant's
making repairs pursuant to Sections 6.1 above or Landlord making repairs
pursuant to Section 6.2 above (where Tenant has failed to make such repairs) and
Section 6.3 above. Tenant expressly waives the benefit of any statute, law or
regulation now or hereafter in effect, including, without limitation, California
Civil Code Sections 1941 and 1942, which would otherwise afford Tenant the right
to make repairs at Landlord's expense or terminate the Lease.

                                   ARTICLE 7

                      IMPROVEMENTS AND ALTERATIONS; LIENS
                      -----------------------------------

     7.1  Original Tenant Improvements. On the Commencement Date Landlord shall
          ----------------------------
deliver possession of the Premises to Tenant in "AS IS" and "WITH ALL FAULTS"
condition. Tenant, at Tenant's sole cost and expense, shall construct and
install all of the Tenant Improvements (as defined in the Work Letter for Tenant
Improvements attached to this Lease as Exhibit D and incorporated herein by this
                                       ----------
reference (the "Work Letter")) within the Premises in a

                                      -13-
<PAGE>

first-class, diligent and workmanlike manner and fully and timely comply with
each and every term, covenant and condition set forth in the Work Letter. Tenant
shall exercise its best efforts to install within the Premises Tenant
Improvements which will have a remaining useful life to Landlord at the
expiration or earlier termination of the Lease.

     7.2  Furniture and Telephone/Network Equipment. During the Term and any
          -----------------------------------------
Extended Term(s) of the Lease, Landlord shall permit Tenant to use all of
Landlord's existing cubicles, office furniture and lobby/conference room
furniture (but excluding all ergonomic furniture and all exam room furniture in
Landlord's health clinic) listed on Schedule 1 attached to this Lease in its
                                    ----------
"AS-IS" and "WITH ALL FAULTS" condition (collectively, the "Remaining
Furniture") (but expressly excluding from the Remaining Furniture Landlord's
office equipment, fixtures and trade fixtures, which Landlord shall remove from
the Premises prior to the Commencement Date). Tenant shall be permitted to use
the Remaining Furniture at no additional rental. Prior to the Commencement Date,
Landlord and Tenant shall jointly make a detailed inspection and written
inventory of the Remaining Furniture to ensure that Schedule 1 both (i) properly
                                                    ----------
describes all of the Remaining Furniture and (ii) properly describes the
physical condition of the Remaining Furniture as of the Commencement Date.
Tenant, at Tenant's sole cost and expense, shall maintain the Remaining
Furniture in as good condition and repair as when received and at the expiration
or earlier termination of the Term of the Lease, Tenant shall return the
Remaining Furniture to Landlord in as good a condition as received, ordinary
wear and tear and damage by fire, other casualty or acts of God excepted. The
Remaining Furniture shall at all times during the Term and any Extended Term(s)
be and remain the sole and exclusive property of Landlord; provided, however,
that Tenant, at Tenant's sole cost and expense, shall be obligated to insure the
Remaining Furniture under its "All-Risk" property insurance policy described in
Section 19.3 below. Any and all insurance proceeds relating to the Remaining
Furniture shall be the sole and exclusive property of Landlord. Landlord and
Tenant hereby agree that the value of the Remaining Furniture for insurance
purposes only is Two Million One Hundred Fifty Six Thousand Nine Hundred Five
DOLLARS ($2,156,905,00). Tenant agrees that the Remaining Furniture shall remain
         --------------
within the Premises and that in no event shall the Remaining Furniture be
removed from the Premises. In addition, on the Commencement Date Landlord shall
leave in place within the Premises Landlord's telephone lines and cable/network
lines; provided, however, that Tenant acknowledges and agrees that (a) on or
before the Commencement Date Landlord shall disconnect all such telephone lines
and cable/network lines from Landlord's central telephone/data network switch
room located in the Joaquin Premises and (b) Tenant, at Tenant's sole cost and
expense, and as part of Tenant's installation of its Tenant Improvements under
the Work Letter, shall install its own dedicated central telephone/data network
switch room and connect its telephone and data network cabling lines to its
central telephone/data network switch room.

     7.3  Alterations by Tenant. Other than the initial Tenant Improvements,
          ---------------------
Tenant shall make no alterations, additions or improvements to the Premises
without the prior written consent of Landlord, which consent shall not be
unreasonably withheld or delayed. Landlord may impose, as a condition of such
consent, such reasonable requirements as Landlord may deem desirable including,
without limitation, the requirement that Tenant remove such alterations,
additions or improvements upon the expiration or earlier termination of the
Lease. Landlord shall advise Tenant in writing at the time Tenant makes its
initial Tenant Improvements under the Work Letter (as to the initial Tenant
Improvements) and at the time Tenant requests

                                      -14-
<PAGE>

Landlord's consent to any subsequent alterations whether Landlord will require
Tenant to remove such alterations from the Premises upon the expiration or
earlier termination of this Lease. Notwithstanding the requirements in this
Section 7.3, nonstructural alterations, additions or improvements which do not
affect building systems or the exterior of the Premises and that cost less than
Fifty Thousand Dollars ($50,000) in the aggregate in any calendar year shall not
require Landlord's prior written consent, but Landlord shall be entitled to at
least ten (10) days prior written notice thereof before Tenant commences such
alterations, additions or improvements. Tenant shall submit all plans and
specifications relating to any proposed alterations, additions or improvements
which exceed Fifty Thousand Dollars ($50,000) in the aggregate in any calendar
year to Landlord for Landlord's prior written approval. No materials used in
Tenant's alterations shall be subject to any security interest or lien and no
part of the Premises shall be subject to any mechanics' or materialmen's lien by
reason of Tenant's alterations. No such alterations shall affect the exterior
appearance of the Premises and it shall be deemed reasonable for Landlord to
refuse to consent to any such alterations. All work approved by Landlord shall
be performed by Tenant or Tenant's contractors in a first-class, diligent and
workmanlike manner and so as not to unreasonably interfere with any owners,
tenants or occupants of adjoining premises or buildings. Tenant shall utilize
for such purposes only licensed contractors and materials reasonably approved in
writing by Landlord (and Landlord hereby approves Vance Brown). Any construction
by Tenant shall be in conformance with the plans and specifications reasonably
approved by Landlord and with any and all applicable rules and regulations of
any federal, state, county or municipal agency or other governmental body having
jurisdiction over the Premises (including, without limitation, the Americans
With Disabilities Act and its state and local counterparts) and with any
applicable codes and ordinances regardless of whether such rules, regulations,
codes or ordinances relate to structural, permanent or non-structural
alterations. All alterations of Tenant shall be done at Tenant's sole cost and
expense. Tenant agrees to give Landlord written notice of the commencement date
of any such approved alterations, improvements, additions or repairs to be made
within the Premises at least ten (10) days prior to the commencement of any such
work in order to give Landlord time to post notices of nonresponsibility. Tenant
further agrees to reimburse Landlord all of Landlord's reasonable costs incurred
for review of any plans and specifications submitted by Tenant for its
alterations (other than the initial Tenant Improvements) and in reviewing the
progress of such alterations, but not to exceed Two-Thousand five Hundred
Dollars ($2,500) for each set of alterations.

     7.4  Liens. Tenant shall keep the Premises free from any liens arising out
          -----
of any work performed, materials furnished or obligations incurred by or for
Tenant. If Tenant fails to keep the Premises free from any such liens and does
not, within twenty (20) days following the imposition of any such lien, cause
the same to be released of record by payment or posting of a proper bond,
Landlord shall have, in addition to all other remedies provided herein and by
law, the right, but not the obligation, to cause such lien to be released by
such means as Landlord shall deem proper, including payment of or defense
against the claim giving rise to such lien. All sums paid by Landlord and all
expenses incurred by it in connection therewith (including attorneys' fees and
costs) shall automatically create an obligation of Tenant to pay an equivalent
amount as Additional Rent, which shall be payable by Tenant on Landlord's demand
with interest as set forth in Section 34.1 below. Such interest charged shall
not constitute Landlord's exclusive remedy nor compromise or limit any other
rights granted Landlord by this Lease or by law or equity. Nothing herein shall
imply any consent by Landlord to subject Landlord's estate

                                      -15-
<PAGE>

to liability under any mechanic's lien law. Tenant may contest the validity
and/or amount of any lien imposed on the Premises, provided that Tenant has
caused such lien to be released of record by the payment or posting of the
proper bond.

                                   ARTICLE 8

                                USE OF PREMISES
                                ---------------

     8.1  Tenant's Use. Tenant shall use and occupy the Premises solely for
          ------------
development, marketing and sale of its Chemdex electronic commerce solutions,
general office purposes, purposes related or incidental thereto, and for no
other use or purpose whatsoever without the prior written consent of Landlord,
which consent may be withheld or conditioned in Landlord's sole discretion.
Tenant covenants and agrees that its electronic commerce solutions business does
not and shall not require Tenant to use or bring onto the Premises, other than
Permitted Materials, any Hazardous Materials, pharmaceuticals, drugs, chemicals
or other materials which are the subject of its electronics commerce solutions
business or otherwise and that Tenant shall not use or bring onto the Premises,
other than Permitted Materials, any Hazardous Materials, pharmaceuticals, drugs,
chemicals or other similar materials (even in di minimus amounts) for any reason
or purpose whatsoever. Tenant shall not use or occupy the Premises in violation
of any law, regulation, code, ordinance or governmental approval or condition
for the Premises, and shall, upon written notice from Landlord, discontinue any
use of the Premises which is not permitted by this Lease. Tenant shall, at
Tenant's sole cost and expense, comply with any directive of any governmental
authority which shall, by reason of the specific nature of Tenant's use or
occupancy of the Premises, impose any duty, condition, order, exaction or other
demand upon Tenant or Landlord with respect to the Premises including, without
limitation, any Environmental Laws, or with respect to the use or occupation
thereof. Tenant shall secure any and all permits and licenses required to
conduct its business in the Premises. Tenant shall not do (or permit any Tenant
Party to do) anything which will invalidate or increase the cost of any
insurance policy covering the Premises and/or property located therein.

     8.2  Nuisance or Waste. Tenant shall not maintain, commit (or permit any
          -----------------
Tenant Party to commit) any nuisance or waste in, on or about the Premises, or
obstruct or interfere in any way with the rights of other tenants or occupants
of the Premises, or injure or annoy them by permitting or making any disturbing
or excessive noise, or by permitting objectionable odors to emanate from the
Premises, or use or allow the Premises to be used by any Tenant Party for any
unlawful purpose. Tenant shall not without Landlord's prior written consent,
place a load upon any floor that exceeds the load per square foot that such
floor is designed to carry or that is then allowed by law.

     8.3  Tenant Sign. Tenant, at Tenant's sole cost and expense, and provided
          -----------
Tenant complies with all applicable laws, statutes, ordinances, codes, rules,
regulations, orders and other lawful requirements of governmental agencies,
shall have the right to install no more than two (2) monument signs at the
Premises. The location(s), type, size, color, content, materials and
illumination of any of Tenant's monument signs shall be subject to Landlord's
prior written approval, which approval shall not be unreasonably withheld or
delayed. Upon the expiration or earlier termination of this Lease, Tenant shall
remove all signs and repair and restore any damage to the Premises caused by
such removal.

                                      -16-
<PAGE>

     8.4  Parking. At all times during the Term and any Extended Terms, Tenant
          -------
shall be permitted to use, on an exclusive basis, all of the parking presently
serving the Premises. Tenant shall satisfy itself in all respects as to the
location and sufficiency of the above-described parking for its intended
purposes and use of the Premises prior to the Commencement Date; provided,
however, that Landlord represents that there are approximately four (4) parking
spaces per 1,000 rentable square feet of the Premises.

                                   ARTICLE 9

                              HAZARDOUS MATERIALS
                              -------------------

     9.1  Environmental Disclosures; As-Is. Landlord hereby discloses to Tenant
          --------------------------------
and Tenant hereby acknowledges that Landlord has advised Tenant that groundwater
in and around the Premises may be contaminated with Hazardous Materials which
were released by parties other than Landlord, including, without limitation,
significant quantities of halogenated volatile organic compounds released into
the groundwater by Teledyne Semiconductor and Spectra-Physics Laser, both of
whom operated facilities located directly upgradient of the Premises. Landlord
has provided Tenant with the groundwater monitoring reports described on
Schedule 2 attached hereto, which Tenant acknowledges receipt of and, except for
- -----------
disclosures to the attorneys, auditors, officers, directors, shareholders,
accountants, investment bankers, lenders, and consultants of Tenant or
disclosures required by law, agrees to keep confidential and not to disclose the
contents thereof (to the extent not a matter of public record) during or
subsequent to the term of this Lease without the prior written consent of
Landlord which Landlord may grant or withhold in its sole discretion. Tenant may
obtain more information about the groundwater in and around the Premises from
publicly available files at the Regional Water Quality Control Board and other
agencies. By entering into this Lease, Tenant acknowledges and agrees (a) that
Tenant has had an opportunity to hire any consultants and make any inquiries
about the environmental condition of the Premises and the soil and groundwater
conditions in and around the Premises that Tenant deems desirable, (b) that
Tenant's representatives and advisors are knowledgeable in real estate and
environmental matters, (c) that Tenant accepts the Premises in "AS-IS" and "WITH
ALL FAULTS" condition and (d) that Tenant is not relying on any warranty or
representation, express or implied, by or on behalf of Landlord with respect to
the Premises including the soil, air and groundwater thereof. Landlord makes no
representations and warranties concerning (x) the environmental condition of the
Premises or the environment in and around the Premises including the soil, air
and groundwater thereof, (y) the presence or absence of Hazardous Materials in
the Premises and the soil, air and groundwater thereof, or (z) the safety of the
Premises for Tenant's employees or the likelihood that by demolition of portions
of the Premises and improving the Premises pursuant to the Work Letter and
occupying and using the Premises, Tenant's employees will be exposed to
Hazardous Materials.

     9.2  Landlord's Indemnity. Except with respect to (i) any soil or
          --------------------
groundwater contamination in and around the Premises existing as of the
Commencement Date and any subsurface mitigation of Hazardous Materials from
other property from and after the Commencement Date and (ii) those matters which
are covered by Tenant's express indemnification and defense obligations set
forth in Section 9.5 below, Landlord shall indemnify, defend and hold Tenant and
its officers, directors, employees, affiliates, subsidiaries, shareholders,
lenders, successors and assigns harmless from and against all claims, damages,

                                      -17-
<PAGE>

liabilities, losses, fines, penalties, consequential damages, costs and
expenses, demands, causes of action, judgments and attorneys' and consultants'
fees, whether foreseeable or unforeseeable, directly or indirectly, to the
extent arising out of Landlord's failure to remove any Hazardous Materials
(other than Hazardous Materials contained within building materials located in
the 1500 and 1550 Plymouth buildings) to the levels required by applicable
Environmental Laws and government agencies having jurisdiction therefor from
within any of the buildings comprising the Premises on or before the
Commencement Date, which indemnity shall include, without limitation, the cost
of any required or necessary repair, cleanup or detoxification of the Premises
and the preparation of any closure or other required plans. Neither the
acknowledgements or agreements of Tenant in Section 9.1 nor the strict
compliance by Landlord with all laws pertaining to Hazardous Materials shall
excuse Landlord from Landlord's obligations of indemnification pursuant to this
Section 9.2. Landlord's obligations pursuant to the foregoing indemnity shall
survive the expiration or earlier termination of this Lease. If any action or
proceeding is brought against Landlord based on the foregoing Landlord, upon
notice from Tenant, shall immediately defend Tenant at Landlord's expense with
counsel reasonably acceptable to Tenant.

     9.3  Compliance with Environmental Laws. Tenant shall, at Tenant's sole
          ----------------------------------
cost and expense, comply with all Environmental Laws applicable to its
operations within the Premises and will at its sole expense obtain, procure and
comply with all permits, licenses and other governmental approvals required for
Tenant's use of the Premises. Tenant shall not permit any Tenant Party to use,
manufacture, handle, treat, transport, produce, dispose of, discharge,
distribute, release, sell, or store any Hazardous Materials (other than
Permitted Materials) in, on or around the Premises during the Term of this
Lease. Notwithstanding the foregoing, Tenant and other Tenant Parties may use,
in compliance with all applicable laws, including Environmental Laws, reasonable
amounts of typical office and janitorial supplies and products typically used in
offices and which are sold over the counter to the public at retail and, during
the construction of the Tenant Improvements or any alterations approved by
Landlord, ordinary and necessary building materials and containerized petroleum
products stored and used in compliance with all laws (collectively, "Permitted
Materials").

     9.4  Investigation and Remediation of Hazardous Materials. Tenant shall
          ----------------------------------------------------
promptly give Landlord copies of any notices, inquiries, claims or documents
received by Tenant from governmental agencies or third parties concerning the
presence of Hazardous Materials in, under and around the Premises, including the
air, soil and groundwater thereof. If, during the Term of this Lease, Tenant, or
Tenant Parties spill, release, discharge, dispose of or introduce Hazardous
Materials to the Premises or if any Hazardous Materials used by Tenant are found
in the soil, atmosphere, surface water or groundwater on, under or about the
Premises due to Tenant's, or Tenant Parties' acts or negligence, Tenant, at
Landlord's option, shall promptly take all actions at its sole cost and expense,
including without limitation, investigation, testing, removal actions,
reporting, cleanup, remediation, and monitoring necessary to return the Premises
and any other affected properties to the condition required by applicable
Environmental Laws, all in accordance with Environmental Laws and the
requirements of all governmental agencies, provided that Landlord's written
approval of such actions shall first be obtained (a "Tenant Cleanup"). Landlord
shall not unreasonably withhold or delay such approval. Tenant shall promptly
provide Landlord with the results of any test, investigation or inquiry
conducted by or on behalf of Tenant in connection with the presence or suspected
presence of Hazardous Material

                                      -18-
<PAGE>

contamination on, under or about the Premises, provided Landlord agrees to keep
the same confidential on the same terms as Tenant pursuant to Section 9.1. With
respect to any Tenant Cleanup, Landlord may, at its election and after
consultation with Tenant concerning remediation costs, control the investigation
and clean-up of the contamination and discussions and negotiations with all
governmental authorities, which shall nevertheless be at Tenant's sole cost and
expense.

     9.5  Tenant Indemnity. Except with respect to (A) any soil or groundwater
          ----------------
contamination in and around the Premises existing as of the Commencement Date
and any subsurface migration of Hazardous Materials from other property that
contaminates the soil and groundwater in and around the Premises from and after
the Commencement Date and (B) those matters which are covered by Landlord's
express indemnification and defense obligations set forth in Section 9.2 above,
Tenant shall indemnify, defend and hold Landlord and its officers, directors,
employees, affiliates, subsidiaries, shareholders, lenders, successors and
assigns harmless from and against all claims, damages, liabilities, losses,
fines, penalties, consequential damages (including diminution of value of the
Premises and lost rent), costs and expenses, demands, causes of action,
judgments and attorneys' and consultant's fees, whether foreseeable or
unforeseeable, directly or indirectly arising out of (i) the release or
discharge during the Term or any Extended Term hereof of any Hazardous Materials
contained in the building materials located in the 1500 or 1550 Plymouth
buildings provided such release or discharge is the result of Tenant's
construction of its initial Tenant Improvements within the Premises and any
subsequent alterations, additions or improvements made by or for Tenant (which
claims include, but are not limited to, employee exposure and toxic tort claims)
and (ii) Tenant's and Tenant Parties' use, handling, generation, storage,
disposal, exposure of others to, emission or release of Hazardous Materials on
or about the Premises during the Term or any Extended Term or a breach of
Tenant's obligations under this Article 9. The foregoing indemnity obligations
shall include, without limitation, the cost of any required or necessary repair,
cleanup or detoxification of the Premises or other properties and the
preparation of any closure or other required plans, whether such action is
required or necessary prior to or following the termination of this Lease.
Neither the written consent by Landlord to the use, generation, storage or
disposal of Hazardous Materials nor the strict compliance by Tenant with all
laws pertaining to Hazardous Materials shall excuse Tenant from Tenant's
obligations of indemnification pursuant to this Section 9.5. Tenant's
obligations pursuant to the foregoing indemnity shall survive the expiration or
earlier termination of this Lease. If any action or proceeding is brought
against Landlord based on the foregoing, Tenant, upon notice from Landlord,
shall immediately defend Landlord at Tenant's expense with counsel reasonably
acceptable to Landlord. Except for Landlord's covenants, agreements and
obligations expressly set forth in this Lease, Tenant hereby waives, releases
and relinquishes any and all rights, claims and causes of action which Tenant
may have or may be entitled to assert against Landlord, whether known or unknown
(a) with respect to the environmental condition of the Premises and the soil,
air and groundwater thereof, including, without limitation, any and all rights,
claims and causes of action arising under or with respect to the California
Health and Safety Code, Title 42 of the United States Code Section 9601 et.
                                                                        --
seq., the federal and state Occupational Health & Safety Acts, and common law
- ------
tort theories and/or (b) arising out of the use, generation, handling, exposure
of others to, disposal or release of Hazardous Materials by Tenant and Tenant
Parties on, in, or about the Premises or a breach of Tenant's obligations under
this Section 9.5. With respect to the foregoing waivers only, Tenant

                                      -19-
<PAGE>

expressly waives the benefits of Civil Code Section 1542 and any similar statute
or common law that would render a waiver of unknown claims unenforceable.

     9.6  Rent Abatement for Hazardous Material Condition. Until such time as
          -----------------------------------------------
any Hazardous Material Condition (not created by Tenant or any Tenant Party),
should it occur, has been remediated in accordance with Environmental Laws such
that the Premises can be safely used and occupied by Tenant for the conduct of
its normal operations at the Premises, the Rent hereunder shall be abated in
proportion to the part of the Premises which is unusable by Tenant for the
conduct of its normal operations at the Premises by reason of such Hazardous
Material Condition.

     9.7  Non-Responsibility of Tenant. Notwithstanding anything to the contrary
          ----------------------------
in Sections 9.1 through 9.6 above or elsewhere in this Lease, except to the
extent set forth in Tenant's indemnity in Section 9.5 above, no provision of
this Lease shall obligate Tenant to investigate, monitor, remove, remediate, or
otherwise respond to, or to indemnify, defend or hold harmless Landlord or any
other person as a result of or in connection with, any Hazardous Materials that
(A) were present in any state or form in, on, under or about the Premises on the
Commencement Date or at any time prior thereto, or (B) which may migrate onto or
under the Premises at any time after the Commencement Date, or (C) which are
otherwise not used, handled, stored, generated, produced, manufactured, disposed
of or introduced in, upon or about the Premises by Tenant or a Tenant Party.

     9.8  Survival. The provisions of this Article 9 shall survive the
          --------
expiration or earlier termination of the Lease for any reason.

                                   ARTICLE 10

                             UTILITIES AND SERVICES
                             ----------------------

     10.1  Utilities and Services for the Premises. Tenant, at Tenant's sole
           ---------------------------------------
cost and expense, shall cause to be provided to the Premises and shall pay
directly for all water, sewer, gas, electric power, heating, ventilating and air
conditioning ("HVAC") and other utilities and services supplied to the Premises
together with any taxes thereon. Tenant shall provide and pay for its own
janitorial services for the Premises and for any security services or systems
desired by Tenant. The janitorial services which Tenant provides to the Premises
shall be comparable to those provided by Landlord in the 1010 Joaquin building.

     10.2  No Security Services. Landlord shall not provide any security
           --------------------
services for the Premises, such security services, if desired by Tenant, being
the sole and exclusive responsibility and cost of Tenant. Tenant hereby waives
any and all claims by reason of Landlord not providing such security services.

     10.3  Interruptions. Notwithstanding the provisions of this Article 10,
           -------------
Landlord shall not be liable for, and Tenant shall not be entitled to, except as
provided below, any abatement or reduction of Rent or other damages, remedies or
relief of any nature whatsoever by reason of the unavailability of any of the
foregoing utilities or services for the Premises regardless of whether such
failure is caused by accident, breakage, repairs, strikes, lockouts or other
labor disturbance

                                      -20-
<PAGE>

or disputes of any character, governmental regulation or moratorium or other
governmental action; provided, however, that if the interruption in utilities or
services is caused by the negligence or willful misconduct of Landlord or any
Landlord Party and such interruption unreasonably interferes with the conduct of
Tenant's business in the Premises, then Tenant shall be entitled to equitable
rent abatement to the extent the Premises are unusable by Tenant in the conduct
of its normal business therein commencing on the second (2/nd/) business day of
such interruption and continuing until such interruption is sufficiently
remedied to permit Tenant to recommence its business operations in the Premises.
Any such failure, stoppage or interruption of any such utilities or services
shall not be construed either as an eviction of Tenant, or relieve Tenant from
the obligation to perform any term, covenant or agreement of this Lease.
Landlord and Tenant shall act jointly and in good faith and exercise their best
efforts to have utility service repaired or restored immediately or as promptly
as possible under the circumstances.

                                  ARTICLE 11

                             RULES AND REGULATIONS
                             ---------------------

          Tenant agrees to abide by and to cause all Tenant Parties to abide by
all reasonable and nondiscriminatory Rules and Regulations for the Premises
imposed by Landlord. Such Rules and Regulations are imposed for the cleanliness,
good appearance, proper maintenance, good order and reasonable use of the
Premises.

                                  ARTICLE 12

                          TAXES ON TENANT'S PROPERTY
                          --------------------------

     12.1  Tenant's Property. Tenant shall be solely liable for and shall pay
           -----------------
prior to delinquency, any and all taxes, levies and assessments imposed upon any
personal property, improvements, equipment, furnishings or trade fixtures placed
by Tenant in or about the Premises (including, without limitation, the Remaining
Furniture), as well as all taxes, levies and assessments imposed on Tenant's
initial Tenant Improvements and on any subsequent alterations, additions or
improvements installed by or on behalf of Tenant within or to the Premises.
Wherever possible, Tenant shall cause all of its personal property,
improvements, equipment, furnishings and trade fixtures and all of its
alterations, improvements and additions to the Premises including, without
limitation, Tenant's initial Tenant Improvements, to be assessed and billed
separately from the real property tax bill for the Premises. If any such taxes,
levies and assessments are levied against Landlord or Landlord's property or if
the assessed value of the Premises is increased by the inclusion therein of a
value placed upon such personal property, improvements, equipment, furnishings
or trade fixtures of Tenant or upon Tenant's alterations, improvements or
additions to the Premises, including Tenant's initial Tenant Improvements,
Tenant shall upon demand pay as Additional Rent all such taxes, levies and
assessments so levied against Landlord.

     12.2  License Fees and Business Taxes. Tenant shall pay, prior to
           -------------------------------
delinquency, all license fees and taxes which may be imposed upon the business
of Tenant conducted on the Premises. Landlord shall not be responsible for the
payment of any such license fees or taxes.

                                      -21-
<PAGE>

                                  ARTICLE 13

                          FIRE OR CASUALTY; ABATEMENT
                          ---------------------------

     13.1  Restoration. If, at any time prior to the last twelve (12) months of
           -----------
the Term, the Premises or any part thereof is damaged or destroyed by fire or
other casualty required to be covered by the "All Risk" Insurance described in
Section 19.4.1 below, the damage and destruction thereto shall be repaired and
the Premises restored by and at the expense of Landlord, but only up to the
amount of available insurance proceeds under the "All Risk" Insurance described
in Section 19.4.1 below (unless no proceeds are available because Landlord
failed to maintain such "All-Risk" Insurance in accordance with this Lease)
provided such repairs can, in Landlord's reasonable opinion, be made within two
hundred seventy (270) days after the occurrence of such damage or destruction
without the payment of overtime or other premiums, and the Lease shall continue
in full force and effect. If such damage or destruction occurs during the last
twelve (12) months of the Term, or is caused by a casualty not required to be
covered by such "All Risk" Insurance, or if, in Landlord's reasonable opinion,
such repairs and restoration cannot be so made within two hundred seventy (270)
days after the occurrence of such damage or destruction, the Lease may be
terminated by Landlord as provided in Section 13.3 below. Additionally, if such
damage or destruction occurs during the last twelve (12) months of the Term or
if, in Landlord's reasonable opinion, such repairs cannot be made within two
hundred seventy (270) days after the occurrence of such damage or destruction,
then the Lease may be terminated by Tenant as provided in Section 13.3 below.

     13.2  Rent Abatement. Until Landlord's required repairs and restoration
           --------------
pursuant to Section 13.1 above are completed, the Rent hereunder shall be abated
in proportion to the part of the Premises which is unusable by Tenant for the
conduct of its normal business or operations at the Premises. If the damage or
destruction is due to the negligence or willful misconduct of Tenant or Tenant's
employees, agents, contractors, subcontractors, invitees or licensees, there
shall be no abatement of Rent regardless of the period during which the Premises
is unusable. If this Lease is not terminated by Landlord or Tenant as provided
in Section 13.3 below, Tenant shall be responsible for making all repairs to
and/or replacement or restoration of its initial Tenant Improvements and its
additions, improvements, alterations and trade fixtures made by or for Tenant to
the Premises and all of its furniture, fixtures, equipment and personal
property, including, without limitation, the Remaining Furniture.

     13.3  Special Elections. If repairs for damage and destruction covered by
           -----------------
Section 13.1 cannot, in Landlord's opinion, be made within two hundred seventy
(270) days after the occurrence of the damage or destruction, or if the damage
or destruction is occasioned by an act for which Landlord is not required under
this Lease to be insured, Landlord may, in its sole and absolute discretion,
elect to make such repairs within a reasonable time and in such event, unless
Tenant shall elect to terminate this Lease as provided below, this Lease shall
continue in effect and the Rent shall be abated in the manner provided in
Section 13.2 above. In all events Landlord's election to make such repairs must
be evidenced by written notice delivered to Tenant within sixty (60) days after
the occurrence of the damage or destruction. If Landlord elects not to make such
repairs and so notifies Tenant, then either party may, by ten (10) days' written
notice to the other, cancel this Lease as of the date of the occurrence of such
damage or destruction, which cancellation shall be effective only as to the
entirety of the particular portion

                                      -22-
<PAGE>

of the Premises that was damaged or destroyed (i.e., either the 1500 Plymouth
building or the 1550 Plymouth building). In addition, and notwithstanding any
desire or election by Landlord to make repairs or rebuild, Tenant, in its sole
discretion, may elect to terminate this Lease (only as to the entirety of the
particular Premises that was damaged or destroyed) by written notice to Landlord
if (i) such damage or destruction occurs during the last twelve (12) months of
the Term, or (ii) if in Landlord's reasonable opinion, such repairs cannot be
completed within two hundred seventy (270) days after the occurrence of such
damage or destruction or (iii) if Landlord fails to notify Tenant within sixty
(60) days following the date of such damage or destruction of Landlord's intent
to repair and restore the Premises.

     13.4  No Claims. In no event shall Tenant be entitled to any claims,
           ---------
relief, remedies, compensation or damages for loss of use of the whole or any
portion of the Premises and/or for any inconvenience or annoyance occasioned by
any such damage, destruction, repair, reconstruction or restoration, Tenant's
sole remedy being the right to Rent abatement as provided for in Section 13.2
above. Tenant hereby waives any statutory rights of setoff and/or termination
that it may have (including but not limited to those contained in California
Civil Code Sections 1932, 1933(4) and 1942) which may arise by reason of any
partial or total destruction of the Premises.

                                  ARTICLE 14

                                EMINENT DOMAIN
                                --------------

     14.1  Total Condemnation. If the whole of the Premises is acquired or
           ------------------
condemned by eminent domain, inversely condemned or sold in lieu of condemnation
for any public or quasi-public use or purpose ("Condemned"), the Term of the
Lease shall terminate as of the date of title vesting in such proceeding and
Rent shall be adjusted as of the date of such termination.

     14.2  Partial Condemnation. If any part (but not all) of the Premises is
           --------------------
Condemned and such partial Condemnation renders the balance of the Premises not
reasonably usable for the normal business or operations of Tenant at the
Premises, as reasonably determined by Landlord and Tenant, then this Lease shall
terminate as of the date of title vesting in such proceeding (or such earlier
date as the Premises are rendered not reasonably usable for the normal business
of Tenant at the Premises) and Rent shall be adjusted to such date. If such
Condemnation is not sufficiently extensive to render the balance of the Premises
not reasonably usable for the normal business of Tenant as reasonably determined
by Landlord and Tenant, then Landlord shall, to the extent of available
Condemnation proceeds from the portion of the Premises Condemned, restore the
Premises to a condition comparable to its condition immediately prior to such
Condemnation less the portion thereof lost in such Condemnation, and this Lease
shall continue in full force and effect and, as of the date of such title
vesting, the Rent shall be equitably reduced as reasonably determined by
Landlord. If any parking areas within the Premises are Condemned to such an
extent that the Premises are not reasonably useable for the normal business of
Tenant as reasonably determined by Landlord and Tenant, then Tenant may elect to
terminate this Lease upon written notice to Landlord. Additionally, (i) if in
the reasonable opinion of Landlord the remaining portion of the Premises not
Condemned cannot reasonably or practicably be repaired or converted so as to
permit substantially the same use for which the Premises was used immediately
prior to the Condemnation, Landlord shall have the right to terminate this Lease
by

                                      -23-
<PAGE>

giving the Tenant at least sixty (60) days' written notice of such termination,
and (ii) if the Condemnation has a material adverse effect upon the means of
access to the Premises or twenty-five percent (25%) or more of the Premises will
be taken through Condemnation, then Tenant shall have the right to terminate
this Lease by giving Landlord at least sixty (60) days' notice thereof.

     14.3  Landlord's Award. Subject to Section 14.4 below, if the Premises are
           ----------------
wholly or partially Condemned, Landlord shall be entitled to the entire award
paid for such Condemnation, and Tenant waives any right or claim to any part
thereof from Landlord or the condemning authority. No award for any partial or
entire taking shall be apportioned, and subject to Section 14.4 below, Tenant
hereby assigns to Landlord any award which may be made in such taking or
Condemnation.

     14.4  Tenant's Award. Tenant shall have the right to claim and recover from
           --------------
the Condemning authority, but not from Landlord, solely such compensation as may
be awarded or recoverable by Tenant in Tenant's own right for (a) the taking of
the unamortized or undepreciated value of any leasehold improvements owned by
Tenant that Tenant has the right to remove at termination of this Lease and that
Tenant elects not to remove, (b) reasonable removal and relocation costs for any
leasehold improvements that Tenant has the right to the remove and elects to
remove (if the Condemning authority approves of the removal), (c) loss of
goodwill, (d) relocation costs under Government Code Section 7262 (the claim for
which Tenant may pursue by separate action independent of this Lease), and (e)
any other amount in addition to the foregoing that does not in any manner or to
any extent reduce the amount of the award payable to Landlord. Tenant shall have
the right to negotiate directly with the Condemning authority for the foregoing
compensation.

     14.5  Temporary Condemnation. If the whole or any part of the Premises
           ----------------------
shall be Condemned for any temporary public or quasi-public use or purpose, this
Lease shall remain in effect and Tenant shall be entitled to receive for itself
such portion or portions of any award made for such use with respect to the
period of the Condemnation which is within the Term. If a temporary Condemnation
remains in force at the expiration or earlier termination of the Term, Tenant
shall pay to Landlord a sum equal to the reasonable cost of performing any
obligations required of Tenant by this Lease with respect to the surrender of
the Premises, including without limitation, repairs and maintenance, and upon
such payment Tenant shall be excused from any such obligations. If a temporary
Condemnation is for an established period which extends beyond the Term, the
Lease shall terminate as of the date of occupancy by the Condemning authority,
and the awards shall be as provided in Sections 14.3 and 14.4.

     14.6  Notice and Execution. Landlord shall, within five (5) business days
           --------------------
of service of process in connection with any Condemnation or potential
Condemnation, give Tenant notice in writing thereof. Tenant shall promptly
execute and deliver to Landlord all instruments that may be reasonably required
to effectuate the provisions of this Article 14. Landlord may, without any
obligation or liability to Tenant, stipulate with any condemning authority for a
judgment of Condemnation without the necessity of a formal suit or judgment of
Condemnation, but only so long as Tenant's right to receive compensation or
damages in a separate proceeding for its trade fixtures, personal property and
relocation expenses is not negated or diminished thereby by this Section. Tenant
hereby waives any statutory rights of termination that it may have arising by

                                      -24-
<PAGE>

reason of the condemnation, including those contained in Section 1265.130 of the
California Code of Civil Procedure.

                                  ARTICLE 15

                           ASSIGNMENT AND SUBLETTING
                           -------------------------

     15.1  General Prohibition. Tenant shall not, either voluntarily,
           -------------------
involuntarily or by operation of law, directly or indirectly, sell, hypothecate,
assign, encumber, mortgage, dispose of or otherwise transfer this Lease (or any
portion thereof), or any of Tenant's beneficial interest therein, or sublet the
Premises or any part thereof, or permit the same to be occupied by anyone other
than Tenant without the prior written consent of Landlord and any attempt to do
so without such prior written consent shall be null and void and shall
constitute an Event of Default hereunder. Subject to the provisions of this
Section 15.1 and Sections 15.2 and 15.3 below, Landlord agrees not to
unreasonably withhold its consent to any proposed assignment or sublease of this
Lease, provided that the proposed assignee or subtenant (i) is reasonably
satisfactory to Landlord as to its creditworthiness, character and business
reputation, (ii) will occupy the Premises solely for the uses permitted under
this Lease and (iii) in the case of an assignment, assumes and agrees to be
bound and directly responsible for all of Tenant's obligations hereunder.
Landlord's consent to any such assignment or sublease shall in no event be
construed as releasing Tenant from any or all of its duties, liabilities or
obligations under this Lease, including, without limitation, the obligation to
pay Rent and all other sums due under this Lease, nor as relieving Tenant from
the requirement of obtaining Landlord's prior written consent to any further
assignment or subletting. Notwithstanding any contrary provisions of this
Article 15 or any contrary provisions of Article 15 of the Joaquin Lease, (a)
during the Term and any Extended Term(s), Tenant may sublease up to, but not
more than, an aggregate of Twenty Thousand (20,000) rentable square feet of
space within the Premises and/or the Joaquin Premises (which 20,000 rental
square feet may, at Tenant's option, include up to, but not more than, Twelve
Thousand (12,000) rentable square feet in the aggregate in the Joaquin
Premises), upon prior written notice to Landlord but without Landlord's consent,
to one (1) or more Tenant Subsidiaries (as defined in Section 1.17 above) and
(b) Tenant may assign this Lease or sublease all or a portion of the Premises,
upon prior written notice to Landlord but without Landlord's consent, to a
Tenant Affiliate (as defined in Section 1.16 above) (with the foregoing
transactions being referred to in this Article 15 as "Internal Transaction.")
Any assignment or sublease to a Tenant Affiliate or a Tenant Subsidiary in any
Internal Transaction shall not release or relieve Tenant of any of its duties,
liabilities or obligations under this Lease including, without limitation, the
obligation to pay Rent and all other charges under this Lease and (x) with
respect to an assignment, such Tenant Affiliate shall assume, in full, all of
the obligations of Tenant under this Lease pursuant to assumption documentation
reasonably acceptable to Landlord and (y) with respect to a sublease, such
Tenant Affiliate or Tenant Subsidiary and the proposed sublease shall comply
with all of the provisions of Section 15.7 set forth below.

     15.2  Lease Termination. If at any time during the Term or any Extended
           -----------------
Term(s) of the Lease, Tenant determines that it wishes to assign or sublease all
or any portion of the Premises to any person or entity prior to marketing such
space to a proposed assignee or subtenant, Tenant shall first deliver a written
notice of the foregoing to Landlord. Landlord shall have the right, in
Landlord's sole and absolute discretion, to be exercised within fifteen (15)

                                      -25-
<PAGE>

business days following Landlord's receipt of Tenant's written notice, to either
(i) subject to the provisions of this Article 15, permit Tenant to proceed with
its plans to assign this Lease or sublet the portion of the Premises which was
the subject of Tenant's written notice or (ii) (A) in the case of a proposed
assignment or sublease of more than sixty percent (60%) of the total rentable
square footage of the Premises, terminate this Lease as to the entire Premises
and release Tenant from its remaining obligations hereunder (other than Tenant's
obligations hereunder which expressly survive the termination of the Lease), (B)
in the case of a proposed assignment or sublease of less than sixty percent
(60%) of the Premises but more than fifty percent (50%) of the total rentable
square footage of either of the two (2) buildings comprising the Premises,
terminate this Lease as to such building ("recaptured building"), release Tenant
from its obligations under this Lease as to such recaptured building (other than
Tenant's obligations under the Lease which expressly survive the termination of
the Lease) and amend the Lease to reflect the reduction in the rentable square
footage of the remaining Premises or (C) in the case of the proposed assignment
or sublease of less than sixty percent (60%) of the Premises and less than fifty
percent (50%) of either of the buildings comprising the Premises, terminate the
Lease with respect to the portion of the Premises that Tenant wishes to sublease
and amend the Lease to reflect the reduction in the rentable square footage of
the remaining Premises; provided that the foregoing termination rights shall not
apply to an Internal Transaction (as defined in Section 15.1 above) (but shall
apply to the subleasing of any space in the Premises and the Joaquin Premises in
excess of 20,000 rentable square feet in the aggregate to Tenant Subsidiaries);
and provided further, that Tenant shall have the right, subject to Landlord's
right (a) to reasonably consent to the proposed subtenant pursuant to Sections
15.1 above and 15.3 below, (b) to receive reimbursement of Landlord's costs
pursuant to Section 15.6 below and (c) to approve the form of sublease agreement
pursuant to Section 15.7 below, to enter into a sublease (and/or a succeeding
replacement sublease of the same space) of up to, but not more than, an
aggregate of Ten Thousand (10,000) rentable square feet of space within the
Premises and/or the Joaquin Premises for a term not to exceed twenty-four (24)
months without giving Landlord the right to terminate the Lease as to such
subleased portion of the Premises. If Landlord elects not to recapture the
Premises or portion thereof which was the subject of Tenant's written notice or
fails to respond in writing to Tenant within such fifteen (15) business day
period, then for a period of six (6) months thereafter, subject to the
provisions of this Article 15, Tenant may proceed with its plans to attempt to
assign or sublease the portion of the Premises which was the subject of Tenant's
written notice.

     15.3  Assignment Information. Provided Tenant has first complied with the
           ----------------------
provisions of Section 15.2 above, if Tenant desires at any time to assign this
Lease or to sublet the Premises or any portion thereof (other than to a Tenant
Affiliate), Tenant shall first notify Landlord of its desire to do so and shall
submit in writing to Landlord (i) the name of the proposed subtenant or assignee
(including a Tenant Subsidiary); (ii) the nature of the proposed subtenant's or
assignee's business to be carried on in the Premises (including a Tenant
Subsidiary); (iii) the terms and conditions of the proposed sublease or
assignment (including complete and accurate copies of all proposed assignment or
sublease documentation) including a sublease to a Tenant Subsidiary; (iv) such
financial and business information as Landlord may reasonably request concerning
the proposed subtenant or assignee (other than a Tenant Subsidiary) including
information concerning the proposed subtenant's or assignee's use, handling,
storage and disposal of Hazardous Materials; and (v) such other information as
Landlord may reasonably request. If Tenant claims that any assignment or
subleasing constitutes an Internal Transaction,

                                      -26-
<PAGE>

Tenant shall provide to Landlord all information required to substantiate such
assignment or subleasing as a bona fide Internal Transaction. Landlord shall
grant or withhold its consent to any proposed assignment or subletting within
ten (10) business days from the date of receiving full and complete copies of
all of the information, materials and documents set forth in this Section 15.3.

     15.4  Rent Increase. The Monthly Base Rent for the portion of the Premises
           -------------
assigned or sublet (the "Applicable Portion") shall be increased to the Monthly
Base Rent for such Applicable Portion prior to such assignment or subletting
plus one hundred percent (100%) of the amount by which any rental payment or
other consideration of any nature whatsoever received by Tenant from the
assignee or subtenant including any Tenant Affiliate or Tenant Subsidiary
(whether received before or after the effective date of such approved assignment
or subleasing) for such Applicable Portion exceeds the Monthly Base Rent paid by
the Tenant to Landlord for such Applicable Portion; provided, however, Tenant
may offset against the increase in Monthly Base Rent hereunder solely (a)
Tenant's actual and reasonable third party brokerage fees and marketing costs
incurred in such assignment or sublease transaction, (b) Tenant's actual and
reasonable attorneys' fees incurred in such assignment or sublease transaction,
and (c) and the costs of reasonable alterations to the Applicable Portion
actually installed or paid for by Tenant in connection with the occupancy of the
Applicable Portion by such assignee or subtenant (amortized over the useful life
of such alternations with interest thereon at Eight Percent (8%) per annum). For
purposes of this Section 15.4, the term "rental payment" shall mean all
consideration paid or given, directly or indirectly, to Tenant for the use of
the Premises or any portion thereof and the term "consideration" shall mean and
include money, services, property or any other thing of value such as warrants,
stock or securities, payment of costs, cancellation of indebtedness, discounts,
rebates and the like and including, without limitation, key money and bonus
money given to Tenant for the use of the Premises or any portion thereof,
whether paid to Tenant before or after the effective date of the assignment or
sublease. Notwithstanding the foregoing, under no circumstances shall Landlord
be entitled to (a) any security deposits or other sums given to Tenant as
security for the assignee's or subtenant's obligations or (b) any portion of any
bona fide consideration paid for any assets of Tenant (other than Tenant's
leasehold interest hereunder and separate and apart from any consideration paid
for the assignment and subleasing) in connection with the sale or other transfer
of such assets by Tenant. "Sublet" and "sublease" shall include a sublease as to
which Tenant is sublessor and any sub-sublease or other subsubtenancy,
irrespective of the number of tenancies and tenancy levels between the ultimate
occupant and Landlord, as to which Tenant receives any consideration, as defined
herein, and Tenant shall require on any sublease which it executes that Tenant
receive the profit from all subsubtenancies, irrespective of the number of
levels thereof. Any rental payment or other consideration which is to be passed
through to Landlord by Tenant shall be paid to Landlord within five (5) days
following receipt by Tenant and shall be paid in cash, irrespective of the form
in which received by Tenant from a subtenant or assignee. Tenant acknowledges
and agrees that the purpose of this Section 15.4 is to ensure that Landlord
receives one hundred percent (100%) of any profit (after subtracting Tenant's
costs and fees described in clauses (a) through (c) hereinabove) from any
assignment or sublease of the Premises (including, without limitation, from
Internal Transactions) that Tenant receives over Monthly Base Rent payable by
Tenant hereunder.

                                      -27-
<PAGE>

     15.5  Stock Transfers. If Tenant is a corporation the stock of which is not
           ---------------
traded on the NYSE, AMEX or NASDAQ exchanges, or if Tenant is a partnership,
limited liability company or unincorporated association, the sale, transfer,
assignment, pledge or hypothecation, other than in connection with any IPO, of
any stock, interest, membership rights or similar interest in such corporation,
partnership, limited liability company or association (as the case may be) in
the aggregate in excess of twenty-five percent (25%) of any class or type of
stock of Tenant or interest in Tenant shall be deemed an assignment within the
meaning of this Article 15 and the corporation, partnership, limited liability
company or association as it exists after such sale, transfer, assignment,
pledge or hypothecation shall be deemed to be a successor and assign of the
Tenant.

     15.6  Costs. In the event that Tenant shall submit a written notice to
           -----
Landlord under Section 15.2 above or assign or sublet the Premises or request
the consent of Landlord to any assignment or subletting, Tenant shall pay
Landlord's reasonable costs and expenses incurred in connection with each such
transaction (including any Internal Transaction), including reasonable
attorneys, architects, engineers or other consultants fees, within ten (10)
business days following written demand therefor from Landlord accompanied by
invoices reasonably substantiating such costs, whether Landlord terminates this
Lease (or any portion thereof), consents to such assignment or subletting or
withholds its consent thereto.

     15.7  Subletting Terms. The following terms and conditions shall apply to
           ----------------
any subletting by Tenant of all or any part of the Premises (including, without
limitation, any subleasing to any Tenant Affiliate or Tenant Subsidiary) and
shall be deemed included in all subleases whether or not expressly incorporated
therein:

           15.7.1 Tenant assigns and transfers to Landlord all of Tenant's
interest in all rentals and income arising from any sublease of the Premises
heretofore or hereafter made by Tenant, and Landlord may collect such rent and
income and apply the same toward Tenant's obligations under this Lease;
provided, however, that until a default (following the expiration of any
applicable grace or cure periods without cure) shall occur in the performance of
Tenant's obligations hereunder, Tenant may receive and collect the rents
accruing under such sublease. Landlord shall not, by reason of this or any other
assignment of such sublease to Landlord or by reason of the collection of rents
from a subtenant, be deemed liable to the subtenant for any failure of Tenant to
perform and comply with any of Tenant's obligations to such subtenant. Tenant
hereby irrevocably authorizes and directs any such subtenant, upon receipt of a
written notice from Landlord stating that a default (following the expiration of
any applicable cure grace period without cure) exists in the performance of
Tenant's obligations under this Lease, to pay to Landlord the rents and all
other sums due and to become due under the sublease until such default has been
cured by Tenant. Tenant agrees that such subtenant shall have the right to rely
upon any such statement and request from Landlord, and that such subtenant shall
pay such rents or other sums to Landlord without any obligation or right to
inquire as to whether such default exists and notwithstanding any notice, demand
or claim from Tenant to the contrary. Tenant shall have no right or claim
against said subtenant or Landlord for any such rents or sums so paid by
subtenant to Landlord.

           15.7.2 No such sublease of the Premises entered into by Tenant shall
be effective unless and until it has been approved in writing by Landlord. An
approved sublease shall not be

                                      -28-
<PAGE>

changed, supplemented or modified, in any manner, without Landlord's reasonable
prior written consent. Any subtenant shall, by virtue of entering into a
sublease under this Lease, be deemed, for the benefit of Landlord, to have
assumed and agreed to perform and comply with each and every obligation herein
to be performed by Tenant with respect to the subleased space other than such
obligations as are contrary to or inconsistent with provisions contained in a
sublease to which Landlord has expressly consented in writing.

           15.7.3 In the event Tenant shall default (following the expiration of
any applicable cure period without cure) in the performance of any of its
obligations under this Lease, Landlord, at its option and without any obligation
to do so, may require any subtenant to attorn to Landlord, in which event
Landlord shall undertake the obligations of Tenant under such sublease from the
time of the exercise of said option to the termination of such sublease;
provided, however, Landlord shall not be liable for any prepaid rents or
security deposit paid by such subtenant to Tenant or for any prior default of
Tenant under such sublease.

                                  ARTICLE 16

                          ACCESS AND RESERVED RIGHTS
                          --------------------------

     16.1  Access Rights. Landlord and its agents, representatives and
           -------------
contractors shall at all reasonable times have the right, but not the
obligation, to enter the Premises to (i) inspect the same; (ii) to show the
Premises to prospective purchasers or tenants (as to prospective tenants, only
during the last twelve (12) months of the Term or Extended Term); (iii) to post
notices of nonresponsibility; and (iv) to alter, improve, maintain or repair the
Premises or any other portion thereof, to test and/or monitor groundwater or
investigate the environmental conditions of the Premises on an ongoing basis as
determined by Landlord in its sole discretion and to install, maintain, repair,
replace and relocate pipes, ducts, conduits, wires, meters and other equipment
within the demising walls, floors, bearing columns, roofs and ceilings of the
Premises, and in the course of such work to close entrances, doors, corridors,
elevators or other Building facilities or temporarily abate their operation, all
without being deemed an eviction or constructive eviction of Tenant and without
abatement of Rent (other than as expressly provided below), and Landlord may for
such purposes erect scaffolding and other necessary structures where reasonably
required by the character of the work to be performed, provided that Landlord,
in connection with each and all of the foregoing, shall use all reasonable
efforts to ensure that the business of Tenant shall be interfered with as little
as is reasonably practicable. If the negligence or willful misconduct of
Landlord or any Landlord Party in carrying out any action pursuant to this
Section 16.1 unreasonably interferes with the conduct of Tenant's business in
the Premises, then Tenant shall be entitled to equitable rent abatement to the
extent the Premises are unusable by Tenant in the conduct of its normal business
therein commencing on the second (2/nd/) business day of such interference and
continuing until such interference is sufficiently remedied to permit Tenant to
recommence its normal business operations in the Premises. Tenant hereby waives
any claim for damages for any injury or inconvenience to or interference with
Tenant's business or loss of quiet enjoyment of the Premises caused by
Landlord's entry on the Premises in accordance with this Section 16.2 (but not
for injury or damage to persons or Tenant's property in the Premises caused by
Landlord's negligence or willful misconduct). For each of the aforesaid
purposes, Landlord shall at all times have and retain a key, pass code for
security devices or other device and be provided with any required information
with which to unlock all of the doors in, upon and

                                      -29-
<PAGE>

about the Premises and gain access to the Premises, excluding Tenant's vaults,
safes, files, security cabinets, and other areas designated as secure by Tenant,
the location and/or installation of which have been previously approved by
Landlord. Landlord shall have the right to use any and all means which Landlord
may deem proper to open said doors in an emergency in order to obtain entry to
the Premises, and any entry to the Premises obtained by Landlord by any of said
means shall not under any circumstances be construed or deemed to be a forcible
or unlawful entry into, or a detainer of, the Premises, or any eviction of
Tenant from the Premises or any portion thereof. No provision of this Lease
shall be construed as obligating Landlord to perform any repairs, alterations or
decoration except as otherwise expressly provided in this Lease. Notwithstanding
anything to the contrary in this Section 16.1 or elsewhere in this Lease,
Landlord and Landlord's agents, representatives and contractors, except in the
case of emergency (where no notice is required), shall provide Tenant with at
least one business day notice prior to each entry of the Premises (except,
however, in the case where Landlord's proposed entry is for the purpose of
performing non-emergency work in the Premises, Landlord shall provide Tenant
with at least two (2) business days prior written notice). If the purpose of
such access is to perform any work in the Premises, said notice from Landlord
shall include a description of the proposed work, the location of the proposed
work the approximate duration of the proposed work, and the names of the persons
to perform the proposed work. Any such entry by Landlord or Landlord's agents,
representatives and contractors, shall comply with all reasonable security
measures of Tenant (including, without limitation, written sign-in, badging, and
accompaniment by a representative of Tenant) and shall not impair Tenant's
operations more than reasonably necessary.

     16.2  Reserved Rights. Landlord further reserves the right from time to
           ---------------
time to change the boundary lines of the lot on which the Premises stands, to
record parcel maps and subdivision maps, and to make other reasonable changes
and to grant other reasonable rights to the exterior portions of the Premises,
including, without limitation, the granting of easements, servitudes, rights of
way and rights of ingress and egress and similar rights to users of adjacent
parcels, utility companies, governmental agencies or other tenants, provided the
same do not interfere with the use, occupancy or quiet enjoyment of the Premises
by Tenant or diminish any of Tenant's rights or increase its obligations under
this Lease. Without limiting the scope of or the generality of foregoing
restrictions on Landlord's rights under this Section 16.2, under no
circumstances may Landlord grant rights which would reduce the parking available
to Tenant hereunder.

                                  ARTICLE 17

                         SUBORDINATION AND ATTORNMENT
                         ----------------------------

     17.1  Subordination. This Lease is junior, subject and subordinate to all
           -------------
existing mortgages, deeds of trust, security assignments, covenants, conditions
and requirements and other security instruments of any kind now encumbering the
Premises or any portion thereof including any renewals, amendments,
modifications, replacements or extensions of the same. Landlord reserves the
right to place new liens and other new encumbrances on the Premises or any part
thereof or interest therein superior in lien and effect to this Lease subject to
Tenant's receipt of commercially reasonable non-disturbance protection in a form
similar to that attached to this Lease as Exhibit E with such changes as may be
                                          ---------
reasonably requested by Landlord's

                                      -30-
<PAGE>

lender or the other party to the agreement (the "Nondisturbance Agreement").
Provided Tenant concurrently or earlier receives an executed Nondisturbance
Agreement from the lienholder or encumbrance, Tenant agrees to execute,
acknowledge and deliver within ten (10) business days following written demand
from Landlord such further instruments evidencing the subordination of this
Lease to any new liens or encumbrances as may be reasonably requested by
Landlord. Notwithstanding such subordination, Tenant's right to peaceful and
quiet possession of the Premises shall not be disturbed by the foreclosure or
termination of future liens or encumbrances so long as Tenant shall pay the Rent
and observe and perform all of the provisions of this Lease to be observed and
performed by Tenant, unless this Lease is terminated pursuant to specific
provisions relating to termination contained herein. In the event of the
foreclosure or termination of any such lien or encumbrance, or the transfer of
title to the Premises, Tenant shall attorn to the then owner who owns or
acquires title to the Premises and shall recognize such owner as Landlord under
this Lease. Tenant agrees to execute and deliver within ten (10) business days
following written demand from such owner any instruments reasonably required to
evidence this attornment.

     17.2 Estoppel Certificates. Tenant shall at any time and from time to time
          ---------------------
upon not less than ten (10) business days' prior written notice by Landlord,
execute, acknowledge and deliver to Landlord a statement in writing certifying
that this Lease is unmodified and in full force and effect (or if there have
been modifications, that the same are in full force and effect as modified and
stating the modifications), the dates to which the Monthly Base Rent and other
charges have been paid in advance, if any, and the amount of the undrawn portion
of the Letter of Credit, and stating whether or not to the actual knowledge of
Tenant, Landlord or Tenant is in default in the performance of any covenant,
agreement or condition contained in this Lease and, if so, specifying each such
default of which Tenant may have actual knowledge, and stating such other
matters of which Tenant may have actual knowledge concerning the status of this
Lease as Landlord may reasonably request. Tenant acknowledges that any such
statement delivered pursuant to this Section may be relied upon by any
prospective purchaser of the Premises or any mortgagee, ground lessor or other
like encumbrance thereof or any assignee of any such encumbrance upon the
Premises. Tenant's failure to deliver such statement within such time shall
constitute a default by Tenant under this Lease and additionally shall be
binding and conclusive upon Tenant (i) that this Lease is in full force and
effect, without modification except as may be represented by Landlord, (ii) that
there are no uncured defaults in Landlord's performance or rights of offset
against Tenant's obligations hereunder, and (iii) that not more than one month's
rent has been paid in advance.

                                  ARTICLE 18

                     TRANSFER OF PREMISES; QUIET ENJOYMENT
                     -------------------------------------

          Any sale, transfer, conveyance or other disposition by Landlord of
Landlord's fee interest in the Premises shall operate to release Landlord from
any and all liabilities, obligations and duties under this Lease accruing from
and after the date fee title to the Premises is conveyed of record to the
transferee. Subject to the provisions of Article 17 hereof, Tenant's right to
peaceful and quiet possession of the Premises shall not be disturbed so long as
Tenant shall pay all Rent and observe and perform all of the provisions of this
Lease to be observed and

                                      -31-
<PAGE>

performed by Tenant, unless this Lease is terminated pursuant to specific
provisions contained herein allowing for such termination.

                                  ARTICLE 19

            NONLIABILITY AND INDEMNIFICATION OF LANDLORD; INSURANCE
            -------------------------------------------------------

     19.1  Indemnification. Except for Losses (defined below) caused by the
           ---------------
willful misconduct of, violation of law by, breach of this Lease or any
provision hereof by, or the negligence of Landlord or its agents, employees,
contractors, licensees or invitees, Tenant agrees to indemnify, defend and hold
harmless Landlord and its directors, officers, employees, agents, partners,
trustees, parents, subsidiaries, shareholders, affiliates, lenders, successors
and assigns from and against any and all claims, damages, liabilities, losses,
fines, penalties, actions or causes of action, judgments, costs and expenses,
including attorneys' fees, investigation costs and costs of court (if any)
(collectively, "Losses"), whether foreseeable or unforeseeable, directly or
indirectly arising out of or relating to, in whole or in part, Tenant's or
Tenant Parties use of the Premises or the conduct of Tenant's business at the
Premises or from any activity, work, or thing done, permitted or suffered by
Tenant or Tenant Parties in or about the Premises, and shall further indemnify,
defend and hold harmless such parties from and against any and all such claims
arising from any breach or default in the performance of any obligation on
Tenant's part to be performed under the terms of this Lease, or arising from the
negligence of Tenant or the Tenant Parties during the Term or any Extended Term,
and from and against all costs, attorneys' fees, expenses, damages, judgments,
actions and liabilities incurred in or concerning any such claim or any action
or proceeding brought thereon. If any action or proceeding is brought against
Landlord by reason of any such claim, Tenant, upon notice from Landlord, shall
immediately defend Landlord at Tenant's sole expense by counsel reasonably
satisfactory to Landlord. The indemnity obligations of Tenant shall not be
limited by available insurance proceeds. Tenant's indemnification and defense
obligations set forth in this Section 19.1 shall survive the expiration or
earlier termination of the Lease.

     19.2  Waiver of Claims. Tenant, as a material part of the consideration to
           ----------------
Landlord, hereby assumes all risk of damage to property or injury to persons,
including Tenant Parties in, upon or about the Premises from any cause
whatsoever, excepting Landlord's or its agents', employees', contractors',
licensees' or invitees' willful misconduct, violation of law, breach of this
Lease or any provision hereof, or negligence, and Tenant hereby waives all known
claims in respect thereof against Landlord. Tenant's obligations set forth in
this Section 19.2 shall survive the expiration or earlier termination of the
Lease.

     19.3  Insurance Obligation. Tenant hereby agrees to obtain, maintain and
           --------------------
keep in full force and effect at all times during the Term and any Extended Term
of this Lease, at Tenant's sole cost and expense, for the protection of Tenant
and Landlord, and, if required by Landlord, Landlord's lenders, policies of
insurance issued by a responsible carrier or carriers qualified to do business
in the State of California and maintaining a rating of at least "A VII" or
better in Best's Insurance Guide and in a form reasonably acceptable to Landlord
which afford the following:

                                      -32-
<PAGE>

          19.3.1  Worker's Compensation Insurance in compliance with California
law and Employer's Liability Insurance with limits of not less than One Million
Dollars ($1,000,000) per occurrence and aggregate. Tenant on behalf of itself
and all persons and parties claiming under or through Tenant, including, without
limitation, Tenant's insurance carriers, waive all rights of subrogation which
Tenant may have against Landlord under applicable worker's compensation
statutes.

          19.3.2  Commercial General Liability Insurance protecting Landlord and
Tenant against claims for death, bodily injury, personal injury and property
damage based upon, relating to or arising out of Tenant's and Tenant Parties'
leasing, use, occupancy, repair and maintenance of the Premises and all areas
appurtenant thereto or from the conduct of Tenant's business or profession or
anything done, permitted or suffered by Tenant in or about the Premises and all
areas appurtenant thereto. Such Commercial General Liability Insurance shall be
written on an occurrence basis and shall provide for a combined single limit of
not less than Two Million Dollars ($2,000,000) per occurrence per location and
shall include, without limitation, Blanket Contractual Liability, Broad Form
Property Damage, Fire Legal Liability, Personal Injury, Completed
Operations/Products Liability (if applicable), Owned and Non-Owned Automobile
Coverage, (included or in a separate policy, with limits of not less than Two
Million Dollars ($2,000,000) per occurrence and aggregate), Protective and/or
Contingent Liability Insurance, Additional Insured-Managers or Landlords of
Premises Endorsement and an Amendment of the Pollution Exclusion for damage
caused by heat, smoke or fumes or from a hostile fire. The policy shall not
contain any intra-insured exclusions as between insured persons and
organizations. The policy shall specifically include coverage for liability
assumed under this Lease as an "insured contract" and shall insure all of
Tenant's indemnity obligations under this Lease including, without limitation,
Tenant's indemnity obligations under Section 19.1 above. The limits of insurance
carded by Tenant as set forth above shall not, however, limit the liability of
Tenant under this Lease or relieve Tenant of any liability under this Lease.

          19.3.3  "All Risk" Insurance, including Fire and Extended Coverage,
Vandalism and Malicious Mischief and Sprinkler Leakage insurance in an amount
equal to the full replacement cost of all of Tenant's initial Tenant
Improvements constructed by or for Tenant pursuant to the Work Letter, all
improvements, additions, alterations and trade fixtures installed within the
Premises by Tenant and all of Tenant's fixtures, furnishings, equipment and
personal property, including, without limitation, all Remaining Furniture, with
a commercially reasonable deductible. The proceeds of the foregoing insurance
shall be used by Tenant solely for the replacement of Tenant's initial Tenant
Improvements and its additions, alterations and trade fixtures installed within
the Premises, and Tenant's fixtures, furnishings, equipment and personal
property, including, without limitation, all Remaining Furniture.

     19.4 Landlord's Insurance Obligations. Subject to Tenant's compliance with
          --------------------------------
Tenant's payment obligations under Article 5 of the Lease with respect to
Landlord's Insurance Premiums, Landlord hereby agrees to obtain, maintain and
keep in full force and effect at all times during the term and any Extended
Term, for the protection of Landlord and, if required by Landlord, Landlord's
lenders, policies of insurance issued by a responsible carrier or carriers
qualified to do business in the State of California and maintaining a rating of
at least "A VII" or better in Best's Insurance Guide which afford the following
coverages:

                                      -33-
<PAGE>

          19.4.1  "All Risk" Insurance with commercially reasonable deductibles
including, without limitation, Fire and Extended Coverage, a Change in Condition
Endorsement with limits adequate to rebuild the Premises in compliance with then
applicable laws, codes and ordinances, Vandalism and Malicious Mischief,
Sprinkler Leakage insurance, and in Landlord's sole discretion, Flood Insurance
and/or Earthquake Insurance, in the name of and for the benefit of Landlord, and
with all proceeds payable to Landlord (and/or any of Landlord's lenders as
Landlord may direct) in an amount equal to the full replacement cost of the
Premises (as the same may be increased from time to time) including, without
limitation, loss or damage to the Premises, but excluding coverage for Tenant's
initial Tenant Improvements constructed by or for Tenant pursuant to the Work
Letter and excluding coverage for any improvements, alterations, additions,
trade fixtures, equipment, furnishings, fixtures and personal property
(including the Remaining Furniture) installed within the Premises by or for
Tenant. Tenant shall be liable for the payment of any deductible amount in the
event of any loss covered by the insurance required under this Section 19.4.1.

          19.4.2  Commercial General Liability Insurance protecting Landlord
against claims for death, bodily injury, personal injury and property damage
based upon, relating to or arising out of Landlord's leasing of the Premises and
all areas appurtenant thereto or anything done, permitted or suffered by
Landlord in or about the Premises and all areas appurtenant thereto. Such
Comprehensive General Liability Insurance shall be written on an occurrence
basis and shall provide for a combined single limit of not less than Five
Million Dollars ($5,000,000) per occurrence per location and shall include,
without limitation, Blanket Contractual Liability, Broad Form Property Damage,
Fire Legal Liability, Personal Injury, Completed Operations/Products Liability,
if applicable, Owned and Non-Owned Automobile Coverage (included or in a
separate policy, with limits of not less than Two Million Dollars ($2,000,000)
per occurrence and aggregate), Protective and/or Contingent Liability Insurance,
Additional Insured-Managers or Landlords of Premises Endorsement and an
Amendment of the Pollution Exclusion for damage caused by heat, smoke or fumes
or from a hostile fire. Tenant shall be named as an additional insured on
Landlord's Commercial General Liability Insurance Policy.

          19.4.3  Business or Rental Interruption Insurance in the name of and
for the benefit of Landlord and with all proceeds payable to Landlord (and/or
any of Landlord's lenders as Landlord may direct), insuring the loss of the Rent
and other charges payable by Tenant to Landlord under this Lease (including all
Monthly Base Rent, Property Taxes, Insurance Premiums, and any scheduled rental
increases for a period not to exceed twelve (12) months). Said insurance shall
contain an agreed valuation provision in lieu of any coinsurance clause, and the
amount of coverage shall be adjusted annually to reflect the projected Rent,
Property Taxes, Insurance Premiums and other expenses, if any, otherwise payable
by Tenant. Tenant shall be liable for any deductible amount in the event of any
loss covered by the insurance required under this Section 19.4.3.

Any insurance required to be carried by Landlord under Sections 19.4.1, 19.4.2
or 19.4.3 above may be carried by Landlord under a blanket insurance policy
covering the Premises and any of Landlord's other locations.

                                      -34-
<PAGE>

     19.5  Policy Terms. All liability insurance required of Tenant under this
           ------------
Article (except Worker's Compensation) shall be primary coverage and shall not
be contributing with any other liability insurance maintained by Landlord.

     19.6  Insurance Certificates. Tenant shall deliver to Landlord at least ten
           ----------------------
(10) business days prior to the time any insurance coverage is first required to
be carried by Tenant, and thereafter at least thirty (30) days prior to
expiration of such policy, certificates of insurance evidencing the required
coverages with limits not less than those specified in Section 19.3 above. The
certificate evidencing the insurance required pursuant to Section 19.3.2 above
shall name Landlord and each of Landlord's lenders (if any), as additional
insureds, and the certificate evidencing the insurance required pursuant to
Section 19.4.2 above shall name Tenant as additional insured. The certificates
to be delivered by Tenant shall expressly provide that not less than thirty (30)
days' prior written notice shall be given to Landlord in the event of
cancellation or non-renewal of the coverages evidenced by such certificates.
Upon written request of Landlord, Tenant shall deliver full and accurate copies
of all insurance policies required of it by this Lease.

     19.7  Disclaimer. Landlord makes no representation that the limits or form
           ----------
of insurance coverage specified to be carried by Tenant under the terms of this
Lease are adequate to protect Tenant against Tenant's undertaking under this
Article 19.

                                  ARTICLE 20

                             WAIVER OF SUBROGATION
                             ---------------------

           Notwithstanding anything to the contrary in this Lease, Tenant and
Landlord each hereby, on behalf of itself and all persons and parties claiming
under or through it, including without limitation its insurance carrier(s),
waive any right of recovery or claim against the other for any damage to or
destruction of any property located in or about the Premises which results from
or arises out of any casualty or event insured or required to be insured
hereunder by any casualty and/or property insurance policy carried by such
waiving party, regardless of the cause or origin of such casualty or event,
including without limitation, the negligence of Tenant or Landlord. Any policy
or policies of fire, extended coverage or similar casualty insurance or of
liability insurance that either party obtains in connection with the Premises or
Tenant's personal property therein shall include a clause or endorsement denying
the insurer and waiving any rights of subrogation against the other party to the
extent rights have been waived by the insured prior to the occurrence of injury
or loss.

                                  ARTICLE 21

                                ATTORNEYS' FEES
                                ---------------

           In the event of any legal action or proceeding brought by either
party against the other arising out of this Lease, the prevailing party (by way
of settlement or final judgment) shall be entitled to recover reasonable
attorneys' fees and costs incurred in such action and such amount shall be
included in any judgment rendered in such proceeding. The provisions contained
in this Article 21 shall survive the expiration or earlier termination of this
Lease.

                                      -35-
<PAGE>

                                  ARTICLE 22

                                    WAIVER
                                    ------

          No waiver by either party hereto of any provision of this Lease or of
any breach by the other party hereunder shall be deemed to be a waiver of any
other provision hereof, or of any subsequent breach by the other party of the
same or any other provision. Landlord's consent to or approval of any act by
Tenant requiring Landlord's consent or approval shall not be deemed consent to
or approval of any subsequent act of Tenant. No act or thing done by Landlord or
Landlord's agents during the Term of this Lease shall be deemed an acceptance or
a surrender of the Premises, unless done in writing signed by Landlord. The
delivery of the keys to any employee or agent of Landlord shall not operate as a
termination of the Lease or a surrender of the Premises. The acceptance of any
Rent by Landlord following a breach of this Lease by Tenant shall not constitute
a waiver by Landlord of such breach or any other breach unless such waiver is
expressly stated in a writing signed by Landlord.

                                  ARTICLE 23

                                    NOTICES
                                    -------

          Any notice, consent, approval, request for consent or approval of or
communication to Landlord or Tenant required or permitted to be given under this
Lease shall be effectively given only if in writing and (i) mailed by United
States Registered or Certified Mail, postage prepaid, return receipt requested,
or (ii) sent by a nationally recognized courier service (e.g., Federal Express)
for next day business delivery, or (iii) personally delivered or served against
receipted copy, or (iv) transmitted via facsimile, in each case addressed to the
recipients at their addresses (or fax numbers in the case of facsimile
transmissions) set forth in Items 3 and 5 of the Basic Lease Provisions. Either
party shall have the right to change the address to which notices shall
thereafter be sent by giving notice to the other party as aforesaid. Notices
given in the aforesaid manner shall be deemed delivered on the date of scheduled
delivery, if sent by courier service, or three (3) days after sending, if sent
by mail, or upon personal delivery or service, if personally delivered or
served, or upon the date of successful facsimile transmission, if sent via
facsimile.

                                  ARTICLE 24

                                  BANKRUPTCY
                                  ----------

          In no event shall this Lease be assigned or assignable by operation of
law and in no event shall this Lease be an asset of Tenant in any receivership,
bankruptcy, insolvency, or reorganization proceeding.

                                      -36-
<PAGE>

                                  ARTICLE 25

                             DEFAULT AND REMEDIES
                             --------------------

     25.1 Events of Default. The occurrence of any of the following shall
          -----------------
constitute a material default and breach of this Lease by Tenant (each, an
"Event of Default"):

          25.1.1  Nonpayment of Rent. Any failure by Tenant to pay Rent or
                  ------------------
Additional Rent or to make any other payment required to be made by Tenant
hereunder on the due date, where such failure continues for three (3) business
days after written notice from Landlord to Tenant demanding such payment;

          25.1.2  Abandonment. Abandonment of the Premises by Tenant;
                  -----------

          25.1.3  Breach of Other Covenants. Any failure by Tenant to observe
                  -------------------------
and perform any obligation, covenant or provision of this Lease to be observed
or performed by Tenant other than those matters specified in Sections 25.1.1 and
25.1.2 above and 25.1.8, 25.1.9, 25.1.10 or 25.1.11 below, where such failure
continues for thirty (30) days after written notice by Landlord to Tenant. If
the nature of such default is such that it cannot reasonably be cured within
such thirty (30) day period Tenant shall not be deemed to be in default if
Tenant shall within such period commence such cure and thereafter diligently
prosecute the same to completion;

          25.1.4  False Statement. Any warranty or representation made by Tenant
                  ---------------
in this Lease proves to be false or misleading in any material respect when
made, including any Financial Statements;

          25.1.5  Insolvency. Tenant or any Guarantor becomes insolvent, as
                  ----------
defined in the Federal Bankruptcy Code, admits in writing its insolvency or its
present or prospective inability to pay its debts as they become due, permits or
suffers a judgment, attachment, execution or judicial seizure to exist against
it which materially adversely affects Tenant's ability to conduct its business
in the ordinary course (unless enforcement thereof is stayed pending appeal)
that is not discharged or dismissed within thirty (30) days, makes an assignment
for the benefit of creditors, or any class thereof, for purposes of effecting a
moratorium upon or extension or composition of its debts, proposed any such
moratorium, extension or composition, or commences or proposes to commence any
bankruptcy, reorganization or insolvency proceeding, or other proceeding under
any federal, state or other law for the relief of debtors;

          25.1.6  Involuntary Bankruptcy. Tenant fails to obtain the dismissal,
                  ----------------------
within sixty (60) days after the commencement thereof, of any bankruptcy,
reorganization or insolvency proceeding, or other proceeding under any law for
the relief of debtors, instituted against Tenant by one or more third parties or
any partner of Tenant, or, in any such proceeding, defaults or files an answer
admitting the material allegations upon which the proceeding was based or
alleges its willingness to have an order for relief entered or its desire to
seek liquidation, reorganization or adjustment of any of its debts;

                                      -37-
<PAGE>

          25.1.7  Receivership. Any receiver, trustee or custodian is appointed
                  ------------
to take possession of all or any substantial portion of the assets of Tenant, or
of Tenant's interest in this Lease;

          25.1.8  Liens. Tenant fails to cause the release, within twenty (20)
                  -----
days after filing, of any lien arising out of any work performed, materials
furnished, or obligations incurred by or for Tenant, which has been filed
against the Premises;

          25.1.9  Assignment. Tenant attempts a transfer, conveyance, mortgage,
                  ----------
encumbrance, pledge, disposition, assignment, sublease or other act in
contravention of Article 15 hereof and fails to cure the same within two (2)
business days of receipt of written notice from Landlord;

          25.1.10 Insurance. Tenant fails to maintain in full force and effect
                  ---------
the insurance coverages required to be maintained by Tenant under this Lease
following written notice thereof from Landlord to Tenant and Tenant's failure to
cure the same within five (5) business days of receipt of such notice; or

          25.1.11 Default Under Joaquin Lease. The occurrence of an "Event of
                  ---------------------------
Default" (as defined in the Joaquin Lease) under the Joaquin Lease shall
constitute an immediate and noncurable Event of Default under this Lease.

     25.2 Remedies of Landlord. In the event of any such Event of Default by
          --------------------
Tenant, Landlord may at any time thereafter, at Landlord's option and without
limiting the exercise of any other right or remedy which Landlord may have in
law or equity by reason of such default or breach, with or without notice or
demand, do any of the following:

          25.2.1  Regain Possession. Re-enter the Premises and take possession
                  -----------------
of the same and of all equipment, fixtures and personal property of Tenant
therein, expel or remove Tenant and all other parties occupying the Premises,
using such force as may be reasonably necessary to do so, without being liable
to any prosecution for such re-entry or for the use of such force, and without
terminating this Lease, and at any time (and from time to time) relet the
Premises or any part thereof for the account of Tenant for such term and upon
such conditions and at such rental as Landlord may deem proper in its sole
discretion. In such event Landlord may receive and collect the rent from such
reletting and apply it first against any and all expenses and costs incurred by
Landlord hereunder as a result of Landlord having to retake and relet the
Premises (including, without limitation, such expenses as Landlord may have
incurred in recovering possession of the Premises, placing the same in good
order and condition, altering, repairing or redecorating the same for reletting
and all other reasonable expenses, commissions and charges, including attorneys'
fees, which Landlord may have paid or incurred in connection with such
repossession and reletting) and then the balance, if any, shall be applied
against any Rent then due from Tenant to Landlord. Landlord may execute any
lease made pursuant hereto in Landlord's name and the tenant thereunder shall be
under no obligation to see to the application by Landlord of any rent collected
by Landlord, nor shall Tenant have any right to collect any rent thereunder.
Whether or not the Premises are relet, Tenant shall pay Landlord all amounts
required to be paid by Tenant up to the date of Landlord's re-entry and
thereafter Tenant shall pay Landlord, until the end of the Term, the amount of
all rent and other charges required to be

                                      -38-
<PAGE>

paid by Tenant hereunder, less the proceeds of such reletting during the Term,
if any, after payment of Landlord's expenses as provided above. Such payments by
Tenant shall be due at such times as are provided in this Lease, and Landlord
need not wait until the termination of this Lease to recover them by legal
action or otherwise. Landlord shall not by any re-entry or other act be deemed
to have terminated this Lease or the liability of Tenant for the total Rent due
hereunder unless Landlord shall give Tenant written notice of Landlord's
election to terminate this Lease.

          25.2.2  Termination. Give written notice to Tenant of Landlord's
                  -----------
election to terminate this Lease at any time after an Event of Default, re-enter
the Premises and take possession of the same and of all equipment, fixtures and
personal property therein, and expel or remove Tenant and all other parties
occupying the Premises, using such force as may be reasonably necessary to do
so, without being liable to any prosecution for such re-entry or for the use of
such force. In such event Landlord shall thereupon be entitled to recover from
Tenant as damages, all of the following:

                  i.   The worth at the time of award of any unpaid Rent which
had been earned at the time of such termination; plus

                  ii.  The worth at the time of award of the amount by which the
unpaid Rent which would have been earned after termination until the time of
award exceeds the amount of such rent loss that Tenant proves could have been
reasonably avoided; plus

                  iii. The worth at the time of award of the amount by which the
unpaid Rent for the balance of the Term after the time of the award exceeds the
amount of such Rent loss that Tenant proves could have been reasonably avoided;
plus

                  iv.  Any other amount necessary to compensate Landlord for all
the detriment proximately caused by Tenant's failure to perform its obligations
under this Lease or which in the ordinary course of things would be likely to
result therefrom, including, but not limited to any costs or expenses incurred
by Landlord in retaking possession of the Premises, including reasonable
attorneys' fees; maintaining or preserving the Premises after such Event of
Default; preparing the Premises for reletting to a new tenant, including repairs
or alterations to the Premises for such reletting; leasing commissions; or any
other costs necessary or appropriate to relet the Premises; plus

                  v.   At Landlord's election, such other amounts in addition to
or in lieu of the foregoing as may be permitted from time to time by the laws of
the State of California.

                  vi.  As used in subsections (i) and (ii) above, the "worth at
the time of award" is computed by allowing interest at the rate set forth in
Article 34 below. As used in subsection (iii) above, the "worth at the time of
award" is computed by discounting such amount at the discount rate of the
Federal Reserve Bank of San Francisco at the time of award plus one percent
(1%).

          25.2.3  Tenant's Property. Landlord may at its option permit all of
                  -----------------
Tenant's fixtures, furniture, equipment, improvements, additions, alterations,
and other personal property to remain on the Premises and in that event, and
continuing during the length of said Event of

                                      -39-
<PAGE>

Default, Landlord shall have the right to take exclusive possession of the same
and to use the same, free of charge, until all Events of Default are cured or,
at its option, at any time during the Term, to require Tenant to forthwith
remove the same. In the alternative, in the event of any entry or taking
possession of the Premises as aforesaid, Landlord shall have the right, but not
the obligation, to remove therefrom all or any part of the personal property
located therein and may place the same in a public warehouse at the expense and
risk of the owner or owners thereof and dispose of the same in accordance with
the provisions of California Civil Code Section 1980 et seq. or any successor
statutes thereto.

          25.2.4  Cure of Default. In addition to the foregoing remedies,
                  ---------------
Landlord shall, so long as this Lease is not terminated, have the right to
remedy any Event of Default, to maintain or improve the Premises without
terminating this Lease, to incur reasonable expenses on behalf of Tenant in
seeking a subtenant, or to cause a receiver to be appointed to administer the
Premises and any new or existing subleases, and Tenant shall pay to Landlord as
Additional Rent hereunder all of Landlord's reasonable costs in so doing, with
interest at the maximum lawful rate.

          25.2.5  Cumulative Remedies. No remedy or election hereunder shall be
                  -------------------
deemed exclusive but shall, wherever possible, be cumulative with all other
remedies at law or in equity.

     25.3 Default by Landlord. Landlord shall not be deemed to be in default or
          -------------------
breach in the performance of any obligation required to be performed by Landlord
under this Lease unless and until it has failed to perform such obligation
within thirty (30) days after written notice by Tenant to Landlord specifying
that Landlord has failed to perform such obligation; provided, however that if
the nature of Landlord's obligation is such that more than thirty (30) days are
required for its performance, then Landlord shall not be deemed to be in default
or breach if it shall commence such performance within such thirty (30) day
period and thereafter diligently prosecute the same to completion. Tenant shall
have no right to terminate this Lease, except where Landlord fails to cure a
material breach within the time periods set forth in the immediately preceding
sentence. No default or breach on the part of Landlord that would entitle Tenant
under the terms of this Lease or by law to terminate this Lease shall result in
a termination of this Lease unless (i) Tenant has given written notice of such
default or breach by registered or certified mail to any beneficiary of a deed
of trust or mortgagee of a mortgage covering the Premises whose address shall
have been furnished to Tenant and (ii) Tenant offers such beneficiary or
mortgagee the same opportunity to cure the default or breach as is available to
Landlord under the express terms of this Lease. It is expressly understood and
agreed that any money judgment against Landlord resulting from any default or
other claim arising under this Lease or related thereto shall be satisfied only
out of Landlord's equity interest in the Premises, and no other real, personal
or mixed property of Landlord, wherever situated, shall be subject to levy on
any such judgment obtained against Landlord and if such equity interest in the
Premises is insufficient for the payment of such judgment, Tenant will not
institute any further action, suit, claim or demand, in law or in equity,
against Landlord for the amount of such deficiency. Tenant hereby waives, to the
extent waivable under law, any right to satisfy said money judgment against
Landlord except from Landlord's equity interest in the Premises.

                                      -40-
<PAGE>

                                  ARTICLE 26

                                   HOLD OVER
                                   ---------

          If Tenant holds over after the expiration or earlier termination of
the Term or any Extended Term of this Lease without the express prior written
consent of Landlord, Tenant shall become a tenant of sufferance only at a rental
rate equal to one hundred fifty percent (150%) of the Monthly Base Rent in
effect just prior to expiration or termination, and otherwise upon the terms,
covenants and conditions herein specified, so far as applicable. Acceptance by
Landlord of any Rent after such expiration or earlier termination shall not
constitute a consent to a holdover hereunder or result in a renewal of the Lease
or any lease. The foregoing provisions of this Article 26 are in addition to and
do not affect Landlord's right of reentry or any other rights of Landlord
hereunder or as otherwise provided by law or equity.

                                  ARTICLE 27

                             CONDITION OF PREMISES
                             ---------------------

          Tenant acknowledges that, except as expressly set forth in this Lease,
neither Landlord nor any agent of Landlord has made any representation or
warranty with respect to the Premises, Landlord's prior use of the Premises, the
presence of any Hazardous Materials in the Premises, the adequacy or inadequacy
of parking for Tenant's intended office use of the Premises, the compliance of
the Premises with any applicable statutes, laws, ordinances or regulations
(including, without limitation, any Environmental Laws), or with respect to the
suitability of any part of the Premises for the conduct of Tenant's business.

                                  ARTICLE 28

                               QUIET POSSESSION
                               ----------------

          Upon Tenant's paying the Rent reserved hereunder and observing and
performing all of the covenants, conditions and provisions on Tenant's part to
be observed and performed hereunder, Tenant shall have peaceful and quiet
possession of the Premises for the entire Term and any Extended Term(s) hereof,
subject to all of the terms and conditions of this Lease.

                                  ARTICLE 29

                          DAMAGE TO TENANT'S PROPERTY
                          ---------------------------

          Landlord and its agents shall not be liable for any damage to Tenant's
property entrusted to employees of Landlord or its agents, nor for loss or
damage to any property by theft or otherwise. Landlord or its agents shall not
be liable for interference with the light or other incorporeal hereditaments.

                                      -41-
<PAGE>

                                  ARTICLE 30

                               CONFLICT OF LAWS
                               ----------------

          This Lease shall be governed by and construed pursuant to the laws of
the State of California.

                                  ARTICLE 31

                            SUCCESSORS AND ASSIGNS
                            ----------------------

          Except as otherwise provided in this Lease, all of the covenants,
conditions and provisions of this Lease shall be binding upon and shall inure to
the benefit of the parties hereto and their respective heirs, personal
representatives, successors and assigns. Any options or rights given to the
Tenant in this Lease to extend or renew this Lease shall be personal to the
original Tenant named herein and to any Tenant Affiliate to whom this Lease may
be assigned and may not be transferred to any other successor or assign
(including, without limitation, any Tenant Subsidiary) without the prior written
consent of Landlord.

                                  ARTICLE 32

                                    BROKERS
                                    -------

          Tenant warrants that it has had no dealings with any real estate
broker, leasing agent or finder in connection with this Lease, excepting only
the brokers named in Items 14 and 15 of the Basic Lease Provisions and that it
knows of no other real estate broker, leasing agent or finder other than the
brokers named in Items 14 and 15 of the Basic Lease Provisions who is entitled
to a commission in connection with this Lease. Tenant agrees to pay and to
indemnify and hold Landlord harmless from, any cost, expense or liability for
any compensation, commission or charges claimed by any other realtors, brokers,
agents or finders claiming by, through or on behalf of Tenant with respect to
this Lease and/or the negotiation thereof. Landlord warrants that it has had no
dealings with any real estate broker, leasing agent or finder in connection with
this Lease, excepting only the brokers named in Items 14 and 15 of the Basic
Lease Provisions and that it knows of no other real estate broker, leasing agent
or finder other than the brokers named in Items 14 and 15 of the Basic Lease
Provisions who is entitled to a commission in connection with this Lease.
Landlord agrees to pay and to indemnify and hold Tenant harmless from, any cost,
expense or liability for any compensation, commission or charges claimed by any
other realtors, brokers, agents or finders claiming by, through or on behalf of
Landlord with respect to this Lease and/or the negotiation thereof. Landlord
covenants and agrees to pay in accordance with its agreement with the broker
named in Item 14, all real estate commissions due in connection with this Lease
to such broker.

                                      -42-
<PAGE>

                                  ARTICLE 33

                             NEGOTIATED AGREEMENT
                             --------------------

          Tenant and Landlord have been represented by independent counsel in
entering into this Lease. Each of the parties affirms to the other that it has
consulted and discussed the provisions of this Lease with its counsel and fully
understands the legal effect of each provision. The drafting and negotiation of
this Lease has been participated in by each of the parties. For all purposes,
this Lease shall be deemed to have been drafted jointly by each of the parties
and shall not be construed against any party due to authorship.

                                  ARTICLE 34

                 INTEREST ON TENANTS OBLIGATIONS; LATE CHARGE
                 --------------------------------------------

     34.1 Interest. Any amount due from Tenant to Landlord which is not paid
          --------
within three (3) business days of its due date shall bear interest at the lesser
of (i) twelve percent (12%) per annum or (ii) the maximum rate permitted by law
from the date such payment is due (after the expiration of any applicable cure
period hereunder, if any) until paid, but the payment of such interest shall not
excuse or cure any default or breach by Tenant.

     34.2 Late Charges. Tenant recognizes that late payment of any Rent or any
          ------------
portion thereof will result in administrative expense to Landlord, the extent of
which additional expense is extremely difficult and economically impractical to
ascertain. Tenant therefore agrees that if Rent or any portion thereof, remains
unpaid ten (10) business days after said amount is due and written notice from
Landlord demanding payment, the amount of such unpaid Rent shall be increased by
a late charge to be paid Landlord by Tenant equal to five percent (5%) of the
amount of the delinquent Rent or other payment. The amount of the late charge to
be paid Landlord by Tenant on any unpaid Rent or other unpaid amount shall be
due immediately after the date on which the late charge was initially imposed.
Tenant agrees that such late charge is a reasonable estimate of the loss and
expense to be suffered by Landlord as a result of such late payments by Tenant
and may be charged by Landlord to defray such loss and expense. The provisions
of this Section in no way relieve Tenant of the obligation to pay Rent or other
amounts on or before the date on which they are due, nor do the terms of this
Section in any way affect Landlord or its obligations under this Lease or
obligate Landlord to accept less than the full Rent amount due at any time.

                                  ARTICLE 35

                                     TIME
                                     ----

          Time is of the essence of this Lease and the performance of any and
all of its provisions.

                                      -43-
<PAGE>

                                  ARTICLE 36

                      DEFINED TERMS AND MARGINAL HEADINGS
                      -----------------------------------

          The words "Landlord" and "Tenant" as used herein shall include the
plural as well as the singular. If more than one person is named as Tenant the
obligations of such persons are joint and several. The captions or marginal
headings to the Articles and Sections of this Lease are not a part of this Lease
and shall have no effect upon the construction or interpretation of any part
hereof.

                                  ARTICLE 37

                               PRIOR AGREEMENTS
                               ----------------

          This Lease and its Exhibits contain all of the agreements of the
parties hereto with respect to any matter covered or mentioned in this Lease,
and no prior agreement, understanding, representation, correspondence
(including, without limitation, that certain letter of intent between the
parties dated June 14, 1999 and that certain Office Lease dated July 30, 1999
covering both the Premises and the Joaquin Premises, which Office Lease the
parties acknowledge and agree shall be null and void and of no further force or
effect upon the execution and delivery of this Lease and the Joaquin Lease by
the parties hereto), or communication pertaining to any such matter or the
Premises shall be effective for any purpose. No provision of this Lease may be
amended, supplemented or modified except by an agreement in writing signed by
the parties hereto or their respective successors in interest. If any provision
of this Lease shall be held invalid, void or unenforceable to any extent, the
remainder of this Lease shall not be affected thereby and each provision of this
Lease shall be valid and enforceable to the fullest extent permitted by law.

                                  ARTICLE 38

                             AUTHORITY OF PARTIES
                             --------------------

          Tenant does hereby covenant, represent and warrant that (i) Tenant is
a duly authorized and existing corporation; (ii) Tenant is qualified to do
business in the State of California and is in good standing in the jurisdiction
of its formation; (iii) Tenant has full right and authority to enter into this
Lease; (iv) each person signing on behalf of the corporation was authorized to
do so; and (v) the Lease is valid and legally binding on Tenant. Landlord does
hereby covenant, represent and warrant that (i) Landlord is duly authorized and
existing corporation; (ii) Landlord is qualified to do business in the State of
California and is in good standing in the jurisdiction of its formation; (iii)
Landlord has full right and authority to enter into this Lease; (iv) each person
signing on behalf of the corporation was authorized to do so; and (v) the Lease
is valid and legally binding on Landlord.

                                      -44-
<PAGE>

                                  ARTICLE 39

                        NO LIGHT, AIR OR VIEW EASEMENT
                        ------------------------------

          Any diminution or shutting off of light, air or view by any structure
which may be erected on lands adjacent to or in the vicinity of the Premises
shall in no way affect this Lease, impose any liability on Landlord, or permit
Tenant to reduce, setoff or abate rent or seek any other remedies or relief.

                                  ARTICLE 40

                             EXAMINATION OF LEASE
                             --------------------

          Submission of this instrument for examination or signature by Tenant
does not constitute a reservation of or option for lease, and it is not
effective as a lease or otherwise legally binding until execution by and
delivery to both Landlord and Tenant.

                                  ARTICLE 41

                                 FORCE MAJEURE
                                 -------------

          Any covenants, conditions, provisions or agreements on the part of one
party to perform any act or thing for the benefit of the other shall not be
deemed breached if such party is unable to furnish or perform the same by virtue
of a strike, lock out, fire, earthquake, explosion, riot, material or supply
shortages, Acts of God, laws, roles, orders, ordinances, directions, regulations
or requirements of any federal, state, county or municipal authority, labor
dispute or any other cause whatsoever beyond such party's reasonable control;
provided, however, that nothing in this Article 41 shall be deemed to relieve
either party from paying the other any sums owed to the other party under this
Lease (including, in the case of Tenant, any Rent) when such sums are due.
Unless expressly provided in this Lease, Tenant's Rent shall not be abated by
reason of such inability on the part of Landlord.

                                  ARTICLE 42

                                   RECORDING
                                   ---------

          Tenant shall not record this Lease nor any form of memorandum hereof
without the prior written consent of Landlord, which consent may be withheld or
conditioned in Landlord's sole and absolute discretion. Any recording of this
Lease or any memorandum hereof without the prior written consent of Landlord
shall constitute a default by Tenant under this Lease. Landlord, in its sole and
absolute discretion, may record this Lease or a memorandum hereof.

                                      -45-
<PAGE>

                                  ARTICLE 43

                          INCORPORATION BY REFERENCE
                          --------------------------

          The Basic Lease Provisions, Addenda (if any) and Exhibits attached
hereto all constitute parts of this Lease and any reference thereto incorporates
such matters in this Lease as if the same were fully set forth herein.

                                  ARTICLE 44

                         DEFINITION OF ADDITIONAL RENT
                         -----------------------------

          The Monthly Base Rent, Property Taxes, insurance premiums, maintenance
and repair costs incurred by Landlord under Article 6 above, and all other
amounts required to be paid by Tenant hereunder ("Additional Rent") including,
without limitation, interest, late charges, advance rent and reimbursements, are
sometimes collectively referred to in this Lease as, and shall constitute "Rent"
or "rent". Demand for payment of Rent shall not constitute a forbearance and
shall not compromise Landlord's right to deem Tenant's failure to pay such Rent
in a timely manner as a default or limit any other rights given to Landlord
under this Lease or by law or equity.

                                   ARTICLE 45

                             SURRENDER OF PREMISES
                             ---------------------

          On the Expiration Date or the earlier termination of the Lease, Tenant
shall surrender the Premises and every part and system thereof to Landlord broom
clean and in as good condition as delivered to Tenant, reasonable wear and tear,
condemnation and casualty excepted, and free of all debris and Hazardous
Materials placed on the Premises by Tenant or Tenant Parties and in full
compliance with all requirements of Section 9.6 above. Unless Landlord has
required removal pursuant to Section 7.3 above, Tenant's initial Tenant
Improvements made by or for Tenant render the Work Letter and all other
improvements, alterations and additions made by or for Tenant to the Premises in
accordance with Section 7.3 of the Lease, shall become part of the Premises on
the Expiration Date or earlier termination of this Lease and be surrendered,
together with the Premises, to Landlord in good, serviceable and operating
condition, reasonable wear and tear, condemnation and casualty excepted. Tenant
shall remove all of its trade fixtures, equipment and personal property and
signs, provided such removal will not adversely affect the structural integrity
of the Premises. Any property not so removed within ten (10) days after the
Expiration Date or earlier termination of the Lease shall be deemed abandoned by
Tenant and shall become Landlord's property which Landlord may use, remove, or
dispose of in accordance with California Civil Code Section 1980 et seq. or any
successor statutes thereto. Tenant shall reimburse Landlord for any cost
incurred by Landlord in such removal, storage or disposition, or in repairing or
restoring the Premises. Tenant shall further defend and indemnify Landlord
against all claims, losses, costs, expenses, actions, judgments, damages and
liabilities resulting from Tenant's failure and delay in surrendering the
Premises as above provided including, without limitation, any claim made by any
succeeding tenant of the Premises resulting from or related to such failure to
surrender, which

                                      -46-
<PAGE>

indemnification and defense obligations shall survive the expiration or earlier
termination of this Lease.

                                   ARTICLE 46

                           NO ACCORD AND SATISFACTION
                           --------------------------

          No payment by Tenant or receipt by Landlord of a lesser amount than
due shall be deemed to be other than on account of the full amount due and
Landlord may accept such check or payment without prejudice to Landlord's rights
to recover the balance.

                                   ARTICLE 47

                                     MERGER
                                     ------

          The voluntary or other surrender of this Lease by Tenant, or a mutual
cancellation thereof, or a termination by Landlord, shall not work as a merger,
and shall, at the option of Landlord, terminate all or any existing subtenancies
or may, at the option of Landlord, operate as an assignment to Landlord of any
or all of such subtenancies.

                                   ARTICLE 48

                              FINANCIAL STATEMENTS
                              --------------------

          The Financial Statements of Tenant were submitted as an inducement and
consideration to Landlord to enter into this Lease. Tenant represents and
warrants to Tenant that the Financial Statements were true and correct as of the
date thereof. Tenant further represents

                                      -47-
<PAGE>

and warrants to Landlord that to Tenant's actual knowledge there have been no
material adverse changes in the financial condition of Tenant since the date of
the Financial Statements.

          IN WITNESS WHEREOF, the parties hereto have executed this Lease,
consisting of the foregoing Basic Lease Provisions and Articles 1 through 48,
together with Exhibits A through E, all of which are incorporated herein in
              --------------------
their entirety by this reference, as of the date set forth above.


LANDLORD:                                    TENANT:


ALZA CORPORATION, a Delaware                 CHEMDEX CORPORATION, a Delaware
corporation                                  corporation


By: /s/ Harold Fethe                         By: /s/ James G. Stewart
    -------------------------------------        ----------------------------
        Harold Fethe

Its: Sr. Vice Pres., Human Resources         Its: James G. Stewart
     ------------------------------------         ---------------------------
                                                  Chief Financial Officer

By: /s/ Peter Staple                         By: /s/ David P. Perry
    -------------------------------------        ----------------------------
        Peter Staple

Its: Sr. Vice President & Gen. Counsel       Its: David P. Perry
     ------------------------------------         ---------------------------
                                                  President & CEO

                                      -48-
<PAGE>

                                   EXHIBIT A
                                   ---------
                          DESCRIPTION OF REAL PROPERTY
                          ----------------------------

          All that certain real property situated in the City of Mountain View,
County of Santa Clara, State of California, described as follows:

     PARCEL ONE:
     ----------

     The Southerly 0.471 acres as shown upon that certain Record of Survey filed
     for record in the office of the Recorder of the County of Santa Clara,
     State of California, on October 3, 1959 in Book 83 of Maps at Page 14.

     PARCEL TWO:
     ----------

     Portion of Lot 39, as shown upon that certain Map entitled, "MAP OF LOS
     ALAMOS ACRES", which Map was filed for record in the office of the Recorder
     of the County of Santa Clara, State of California on March 19, 1929 in Book
     "X" of Maps, at Pages 28 and 29, and more particularly described as
     follows:

     BEGINNING at a point in the centerline of Joaquin Road, distant thereon
     268.9 feet Northerly from the point of intersection of said centerline of
     Joaquin Road, with the centerline of Plymouth Street, as said Road and
     Street are shown on the Map above referred to; running thence Northerly
     along the centerline of Joaquin Road, 100 feet to the Northeasterly corner
     of Lot 39, as said Lot is shown on the Map above referred to; running
     thence Westerly along the Northerly line of said Lot 39, 118.3 feet to the
     Northwesterly corner thereof; running thence Southerly along the Westerly
     line of said Lot 39, 100 feet; running thence Easterly and parallel with
     the said centerline of Plymouth Street, 118.03 feet to the point of
     beginning.

     PARCEL THREE:
     ------------

     Portion of Lot 39, as shown upon that certain Map entitled, "MAP OF LOS
     ALAMOS ACRES", which Map was filed for record in the Office of the Recorder
     of the County of Santa Clara, State of California, on March 19, 1929 in
     Book X of Maps, at Pages 28 and 29, and more particularly described as
     follows:

     BEGINNING at the point of intersection of the center line of Joaquin Road,
     40 feet wide, with the center line of Plymouth Street, 40 feet wide, as
     said road and street are shown upon the Map hereinabove referred to; thence
     North along said center line of Joaquin Road, 268.9 feet to the
     Southeasterly corner of the Parcel of land conveyed by Carmelo J. Judice,
     et ux, to Clifford Davy, et ux, by Deed dated April 13, 1946 and recorded
     August 20, 1946 in Book 1363 Official Records, Page 324, Santa Clara County
     Records; thence along the Southerly line of said Parcel of land and
     parallel with said center line of Plymouth Street, North 86 degrees 01'
     West 118.3 feet to the Westerly line of Lot 39, as shown on said Map;
     thence South along said Westerly line of Lot 39, 268.9 feet to said center
     line of Plymouth Street; thence along said last mentioned line, South 86
     degrees 01' East 118.03 feet to the point of beginning.

     PARCEL FOUR:
     -----------

     All of Lot 38, as shown on that certain Map entitled, "MAP OF LOS ALAMOS
     ACRES", which Map was filed for record in the office of the Recorder of the
     County of Santa Clara, State of California, on March 19, 1929, in Book X of
     Maps at Pages 28 and 29.

     PARCEL FIVE:
     -----------

     All of Lot 37, as shown on that certain Map entitled, "MAP OF LOS ALAMOS
     ACRES", which Map was filed for record in the office of the Recorder of the
     County of Santa Clara, State of California, on March 19, 1929, in Book X of
     Maps at Pages 28 and 29.

                                      -1-
<PAGE>

                                   EXHIBIT B
                                   ---------

<TABLE>
<CAPTION>
            Lease Period                                 Monthly Base Rent

Original Lease Term
- -------------------
<S>                                          <C>
Commencement Date to 10/14/00                $228,000 (subject to free rent per (S) 3.2)

10/15/00 to 10/14/01                                        $234,840
10/15/01 to 10/14/02                                        $241,885
10/15/02 to 10/14/03                                        $249,142
10/15/03 to 10/14/04                                        $256,616
10/15/04 to 02/28/05                                        $264,314

Extended Terms
- --------------

03/01/05 to 10/14/05                                        $264,314
10/15/05 to 10/14/06                                        $272,244
10/15/06 to 02/28/07                                        $280,411
</TABLE>

                                      -1-
<PAGE>

                                   EXHIBIT C
                                   ---------
                            FORM OF LETTER OF CREDIT

                             WELLS FARGO BANK, N.A.
                  TRADE SERVICES DIVISION, NORTHERN CALIFORNIA
                         525 MARKET STREET, 25TH FLOOR
                        SAN FRANCISCO, CALIFORNIA 94105

                          IRREVOCABLE LETTER OF CREDIT

ALZA Corporation                          Letter of Credit No. NZS ________
950 Page Mill Road                        Date: _________ __, 1999
Palo Alto, CA 94304
Attention: Senior Vice President & General Counsel

Ladies and Gentlemen:

     At the request and for the account of Chemdex Corporation, 3950 Fabian Way,
Palo Alto, CA 94303, we hereby establish our Irrevocable Letter of Credit in
your favor in the amount of One Million Eight Hundred Seventy-Five Thousand
United States Dollars (US$1,875,000) available with us at our above office by
payment of your draft(s) drawn on us at sight in the form of Exhibit 1 hereto
with the instructions in brackets therein complied with accompanied by your
signed and dated statement in the form of Exhibit 2 hereto with the instructions
in brackets therein complied with.

     Each drawing must also be accompanied by the original of this Letter of
Credit for our endorsement on this Letter of Credit of our payment of such
drawing.

     Partial and multiple drawings are permitted under this Letter of Credit,
however each drawing must be in an amount of not less than US$20,000.00.

     If any instructions accompanying a drawing under this Letter of Credit
request the payment is to be made by transfer to an account with us or at
another bank, we and/or such other bank may rely on an account number specified
in such instructions even if the number identifies a person or entity different
from the intended payee.

     This Letter of Credit expires at our above office on July 31, 2000, but
shall be automatically extended, without written amendment, to July 31 in each
succeeding calendar year up to, but not beyond, April 30, 2005 unless we have
sent written notice to you at your address above by registered mail or express
courier that we elect not to renew this Letter of Credit beyond the date
specified in such notice (the "Non-Renewal Expiration Date"), which Non-Renewal
Expiration Date will be July 31, 2000 or any subsequent July 31 occurring before
April 30, 2005 and be at least 60 calendar days after the date we send you such
notice.

                                      -1-
<PAGE>

     This Letter of Credit is transferable one or more times, but in each
instance to a single transferee and only in the full amount available to be
drawn under this Letter of Credit at the time of such transfer. Any such
transfer may be effected only through ourselves and only upon presentation to us
at our above-specified office of a duly executed instrument of transfer in the
form attached hereto as Exhibit 3 with the instructions in brackets therein
complied with together with the original of this Letter of Credit. Any transfer
of this Letter of Credit may not change the place of expiration of this Letter
of Credit from our above-specified office. Each transfer shall be evidenced by
our endorsement on the reverse of the original of this Letter of Credit, and we
shall deliver the original of this Letter of Credit so endorsed to the
transferee. All commissions and charges in connection with this transfer are for
the account of Chemdex Corporation.

     This Letter of Credit is subject to the Uniform Customs and Practice for
Documentary Credits (1993 revision), International Chamber of Commerce
Publication No. 500, and engages us in accordance therewith.

                                    Very truly yours,

                                    WELLS FARGO BANK, N.A.

                                    BY:
                                       ------------------------
                                        (AUTHORIZED SIGNATURE)

                                      -2-
<PAGE>

                                   Exhibit 1
                             Wells Fargo Bank, N.A

                          Letter of Credit No. __________

Wells Fargo Bank, N.A.
Trade Services Division, Northern California
525 Market Street
San Francisco, CA 94105

Attention: Manager, Standby Letter of Credit Dept.

                                     DRAFT

                                         Date of Draft: [insert date]

          To the order of [insert Beneficiary Name], pay [insert amount of
drawing in words]
UNITED STATES DOLLARS (U.S. $ [insert amount of drawing in numbers]) at
sight

          For value received under Letter of Credit No. __________

          "Drawn under Wells Fargo Bank, N.A. Letter of Credit No. __________
dated August __,1999."


                                    [insert Beneficiary Name]

                                    By: [insert signature]
                                    Its: [insert title]

                                      -3-
<PAGE>

                                   Exhibit 2
                             Wells Fargo Bank, N.A

                          Letter of Credit No. __________

Wells Fargo Bank, N.A.
Trade Services Division, Northern California
525 Market Street
San Francisco, CA 94105

Attention: Manager, Standby Letter of Credit Dept.

     Re: Letter of Credit No. __________

Ladies and Gentlemen:

     1.  The undersigned Beneficiary, [insert Beneficiary Name], is Landlord
under that certain Office Lease dated August __, 1999 ("Lease") with Chemdex
Corporation, a Delaware corporation, as Tenant.

     2.   The undersigned Beneficiary is entitled to payment under the Lease in
the amount of U.S.$[insert amount of draft which accompanies this statement]
(the "Draw Amount") in accordance with the applicable provisions of the Lease
(as the same may have been amended to date), which is the same amount as the
Draft accompanying this Certificate and is less than or equal to the amount
currently available under the Letter of Credit.

     3.  The individual executing this Certificate on behalf of Beneficiary is a
duly authorized officer of Beneficiary.


Date: [insert date]                 [insert Beneficiary Name]



                                    By: [insert signature]
                                    Its: [insert title]

                                      -4-
<PAGE>

                                   Exhibit 3
                             Wells Fargo Bank, N.A

                         Letter of Credit No. __________

                                                       Date: [insert date]

Wells Fargo Bank, N.A.
Trade Services Division, Northern California
525 Market Street, 25th Floor
San Francisco, California 94105
Attention: Manager, Standby Letter of Credit Department

Subject: Your Letter of Credit No. __________
Ladies and Gentlemen:

     For value received, we hereby irrevocably assign and transfer all our
rights under the above-captioned Letter of Credit, as heretofore and hereafter
amended, extended or increased, to:


               ______________________________
               [ insert Name of Transferee]


               ______________________________

               ______________________________
               [ insert Address of Transferee]

     By this transfer, all of our rights in the Letter of Credit are transferred
to the transferee, and the transferee shall have sole rights as beneficiary
under the Letter of Credit, including sole rights relating to any amendments,
whether increases or extensions or other amendments, and whether now existing or
hereafter made. You are hereby irrevocably instructed to advise furore
amendment(s) of the Letter of Credit to the transferee without our consent or
notice to us.

     You are hereby advised that [ insert Name of Transferee] succeeded to all
of beneficiary's right, title and interest under that certain Office Lease dated
August __, 1999 (as the same may have been amended to date), with Chemdex
Corporation, a Delaware corporation, as Tenant.

     Enclosed are the original Letter of Credit and the original of all
amendments to this date. Please notify the transferee of this Transfer and of
the terms and conditions of the Letter of

                                      -5-
<PAGE>

Credit as transferred. All fees and charges in connection with this Transfer are
for the account of Chemdex Corporation.

                                    Very truly yours,

                                    [Insert Name of Beneficiary]

                                    By: [insert signature]
                                    Its:[insert title]

Signature of Transferor Guaranteed
[Insert Name of Bank]
By: [insert signature]
Name: [insert typed or printed name]
Title: [insert title]

                                      -6-
<PAGE>

                                   EXHIBIT D
                                   ---------

                      WORK LETTER FOR TENANT IMPROVEMENTS

     1.   Delivery of Possession. Landlord shall deliver possession of the
          ----------------------
Premises to Tenant in "AS-IS" and "WITH ALL FAULTS" condition on the
Commencement Date (as defined in Section 2.1 of the Lease) to permit Tenant and
the Contractor Group (defined below) to commence and diligently pursue to
completion the Tenant Improvements (defined below) within the Premises. Tenant
acknowledges that Landlord has no obligation whatsoever to alter, repair,
restore, upgrade or improve the Premises under this Work Letter for Tenant
Improvements ("Work Letter"). As used herein, "Contractor Group" shall mean the
General Contractor (defined below) and each of its subcontractors, sub-
subcontractors, laborers, materialmen and suppliers providing labor or materials
to the Tenant Improvements. Capitalized terms used in this Work Letter and not
defined herein shall have the meanings given them in the Lease.

     2.   Tenant Improvements. Tenant, at its sole cost and expense, shall
          -------------------
construct and install within the Premises its desired tenant improvements and
other improvements in accordance with the Approved Working Drawings (defined
below), which tenant improvements may include, without limitation, (i)
demolition of certain limited existing interior walls and other improvements
within the Premises, (ii) construction, installation and/or reconfiguration of
certain ceilings, interior walls and partitions, interior finishing of exterior
walls (including, without limitation, the plastering, furring, drywalling,
taping and/or other finishing of such walls), interior doors, floor coverings
and the preparation of all floors for same, cabinetry and millwork, restrooms,
light fixtures, wall coverings and other improvements, finishings and painting
within the Premises, (iii) modifications to floors for above-normal floor
loading requirements of Tenant, (iv) modifications reasonably required by Tenant
to the heating, ventilating and air conditioning ("HVAC") systems, ducts and
means of distribution for the same within the Premises, (v) improvements,
additions, alterations and fixtures within the buildings on the Premises
necessary for all Tenant Improvements and all portions of all buildings affected
by the Tenant Improvements to comply with all applicable codes, statutes, rules,
regulations, ordinances and orders of any federal, state, county or municipal
agency having jurisdiction over the Premises including all local, state and
federal requirements for disability access including, without limitation, the
Americans With Disabilities Act, 42 U.S.C. Section 1201 et seq. and California
Government Code Section 4450 et seq. (collectively, "ADA"), (vi) all telephone,
telecommunication, computer and data systems, switch room, cabling, lines,
conduit, receptacles, switches and related equipment and improvements running
from point of entry in the Premises, and (vii) all other necessary, desirable or
required improvements, alterations, fixtures and finishes which are to be
installed within or incorporated into the Premises by Tenant (collectively, the
"Tenant Improvements"). Tenant shall commence to construct and install the
Tenant Improvements at Tenant's sole cost and expense promptly from and after
Commencement Date and diligently pursue to completion, subject to Force Majeure
delays, the construction of all Tenant Improvements.

                                      -1-


<PAGE>

     3.   Working Drawings.
          ----------------

          3.1  Selection of Architect and Engineer; Working Drawings. Tenant
               -----------------------------------------------------
shall retain a reputable architect (the "Architect") to the extent required by
Landlord and as approved by Landlord, which approval shall not be unreasonably
withheld or delayed, to prepare the "Working Drawings", as that term is defined
in this Section 3.1. No Working Drawings shall be required for carpeting,
painting and other di minimus improvements within the Premises. If necessary to
construct or install the Tenant Improvements, Tenant shall also retain an
engineering design build contractor (the "Engineer") approved by Landlord, which
approval shall not be unreasonably withheld or delayed, to prepare all plans and
engineering working drawings relating to any HVAC work or reconfiguration to be
performed by or for Tenant in the Premises. If Landlord fails to disapprove
Tenant's proposed Architect or Engineer in writing to Tenant, as the case may
be, within five (5) business days after receipt of written notice from Tenant
identifying the same, then Landlord shall be deemed to have approved Tenant's
proposed Architect or Engineer, as the case may be. The plans and drawings to be
prepared by Architect and the Engineer (if any) hereunder are collectively
referred to herein as the "Working Drawings." All Working Drawings shall be
subject to Landlord's approval, which approval shall not be unreasonably
withheld or delayed. Landlord shall advise Tenant within ten (10) business days
after Landlord's receipt of the proposed Working Drawings if the Working
Drawings are unsatisfactory, with a reasonable description of any matters found
to be not acceptable to Landlord. If Landlord fails to return Tenant's proposed
Working Drawings to Tenant marked "Approved", "Approved as Noted" or
"Disapproved" within said ten (10) business-day period, then Landlord shall be
deemed to have approved Tenant's proposed Working Drawings. Tenant's Working
Drawings, as finally revised and marked or deemed approved by Landlord, shall be
initialed by Landlord and Tenant and shall be referred to as the "Approved
Working Drawings". If Approved Working Drawings are not agreed upon within five
(5) business days after delivery to Tenant of "Disapproved" Working Drawings or
"Approved as Noted" Working Drawings, then Landlord or Tenant may submit the
disputed items to an arbitration panel consisting of Landlord's architect, an
architect appointed by Tenant (who may be the Architect who prepared Tenant's
Working Drawings), and a third architect appointed by said architects. Tenant
shall appoint its architect within five (5) business days after written notice
from Landlord. The majority decision of such panel shall be made within five (5)
business days after appointment of said third architect and such decision shall
be binding upon Landlord and Tenant and judgment upon the decision of the
arbitrators may be entered in any court having jurisdiction. Landlord and Tenant
shall each pay the fees of their own architect and one-half (1/2) of the fees of
the third architect.

          3.2  Space Plan. Tenant shall cause a space plan ("Space Plan") for
               ----------
the Tenant Improvements to be prepared (including a layout and designation of
all offices, stairways, stairwells, elevators, utility rooms, storage areas,
conference and meeting rooms and other partitioning within the Premises). The
Space Plan shall be subject to Landlord's approval, which approval shall not be
unreasonably withheld or delayed. Landlord shall advise Tenant within ten (10)
business days after Landlord's receipt of the proposed Space Plan if the Space
Plan is unsatisfactory, with a reasonable description of any matters found to be
not acceptable to Landlord. If Landlord fails to return Tenant's proposed Space
Plan to Tenant marked "Approved", "Approved as Noted" or "Disapproved" within
said ten (10) business-day period,

                                      -2-


<PAGE>

then Landlord shall be deemed to have approved Tenant's proposed Space Plan.
Tenant's Space Plan, as finally revised and marked or deemed approved by
Landlord, shall be initialed by Landlord and Tenant and shall be referred to as
the "Approved Space Plan". If the Approved Space Plan is not agreed upon within
five (5) business days after delivery to Tenant of a "Disapproved" Space Plan or
an "Approved as Noted" Space Plan, then Landlord or Tenant may submit the
disputed items to an arbitration panel as provided in Section 3.1 above. Any
material revisions or amendments to the Approved Space Plan shall require
Landlord's prior written approval not to be unreasonably withheld or delayed.

          3.3  INTENTIONALLY DELETED

          3.4  Approved Working Drawings. Tenant shall, at Tenant's sole cost
               -------------------------
and expense, submit the Approved Working Drawings to the City of Mountain View
to the extent necessary to obtain any and all demolition, building and other
governmental permits as may be required by law to commence construction of the
Tenant Improvements. Tenant hereby agrees that neither Landlord nor Landlord's
consultants shall be responsible for obtaining any permits or certificates of
occupancy or other occupancy permits or approvals for the Premises and that the
obtaining of the same if required by law shall be Tenant's sole responsibility
at Tenant's sole cost. No material modifications to the Approved Working
Drawings may be made without the prior written consent of Landlord, which
consent shall not be unreasonably withheld or delayed. If Landlord fails to
disapprove any proposed, modifications to the Approved Working Drawings within
five (5) business days after receipt of written notice from Tenant or its
Architect identifying the same, then Landlord shall be deemed to have approved
such proposed modifications. Construction of the Tenant Improvements by Tenant
and the Contractor Group shall not commence unless and until Tenant has obtained
all legally required demolition, building and other governmental permits
necessary for commencing construction of the Tenant Improvements and delivered
copies of all such permits to Landlord.

          3.5  Approvals Not Binding on Landlord. Landlord's and Landlord's
               ---------------------------------
consultants' review of the Working Drawings and Space Plan as set forth in this
Section 3 shall be for Landlord's sole purpose and shall not imply any
representation or warranty as to the adequacy or sufficiency of the same by
Landlord or Landlord's construction manager, space planners, architects,
engineers and consultants, or obligate Landlord to review the same for quality,
design, code compliance or other like matters. Accordingly, notwithstanding that
any Working Drawings or Space Plan are reviewed by Landlord or its consultants,
and notwithstanding any advice or assistance which may be rendered to Tenant by
Landlord or Landlord's consultants, Landlord and Landlord's construction
manager, space planner, architect, engineers and consultants shall have no
liability whatsoever for such review or advice and shall not be responsible for
any omissions or errors contained in the Working Drawings, Space Plan, Approved
Working Drawings, or Approved Space Plans of any nature whatsoever.

     4.   Construction of Tenant Improvements. Tenant, at Tenant's sole cost and
          -----------------------------------
expense, shall perform or cause to be constructed within the Premises all of the
Tenant Improvements in accordance with the Approved Working Drawings and only
after receipt of all demolition, building and other governmental permits as may
be required by law to commence construction of the Tenant Improvements. No
materials used in the Tenant Improvements shall be subject to any

                                      -3-


<PAGE>

security interest or lien. All materials (as well as methods and processes) used
in the performance of the Tenant Improvements shall be of new and first-class
quality. Tenant shall ensure that its General Contractor and members of the
Contractor Group are familiar with all those portions of the Premises upon or
within which the Tenant Improvement Work will be performed. The Tenant
Improvements as constructed shall not materially alter or affect the exterior
appearance or the structure of the Premises or any of the mechanical,
electrical, plumbing, HVAC or other building systems serving the Premises,
unless such alterations or modifications are provided for in the Approved
Working Drawings or otherwise expressly agreed to in writing by Landlord. All
Tenant Improvements shall be performed diligently (subject to Force Majeure
delays), in a good and workmanlike manner and in accordance with any and all
applicable codes, statutes, rules, regulations, ordinances and orders of any
federal, state, county or municipal agency or other governmental body having
jurisdiction over the Premises, including, without limitation, the ADA, the
Uniform Building Code, California Health and Safety Code (S)(S) 19955 et seq.,
OSHA, 29 U.S.C. (S)(S) 651 et seq. and CAL-OSHA. During the Term or any Extended
Term, Landlord shall not be responsible for repairing or otherwise correcting
any defects in the Tenant Improvements (including any failure of the Tenant
Improvements to comply with applicable laws) that may occur during or after
completion of construction whether such defects affect the Premises or any part
thereof. Except as may be permitted under the Approved Working Drawings, Tenant
shall not demolish, remove or alter any structural portion of the Premises
without Landlord's prior written consent, which Landlord agrees not unreasonably
withhold or delay.

     5.   Tenant's General Contractor and Construction Contract. Tenant shall
          -----------------------------------------------------
have the right to solicit bids from duly licensed reputable contractors for
construction and installation of the Tenant Improvements. Landlord shall have
the right to approve, within five (5) business days of full and complete
submittal to Landlord, each of Tenant's general contractors for the Tenant
Improvements and the form of construction contract to be entered into between
Tenant and such general contractor with respect to the construction and
installation of the Tenant Improvements, and those subcontractors and forms of
subcontracts for subcontracts where the subcontractor is providing work,
materials and/or supplies in excess of $100,000 (collectively, $100,000
Subcontractors" and "$100,000 Subcontracts", as applicable), which approvals
shall not be unreasonably withheld or delayed. Any disapproval of any of the
foregoing by Landlord shall contain a reasonable description of any matters
found to be not acceptable to Landlord. If Landlord fails to approve or
disapprove Tenant's proposed general contractor within said five (5)-business-
day period (and Landlord hereby preapproves Vance Brown Contractors) or to
return Tenant's proposed construction contract to Tenant marked "Approved,"
"Approved as Noted," or "Disapproved" within said five (5)-business-day period,
then Landlord shall be deemed to have approved the same. The construction
contract for the Tenant Improvements (the "Construction Contract") between
Tenant and the general contractor approved (or deemed approved) by Landlord (the
"General Contractor") shall provide, and Tenant shall exercise commercially
reasonable efforts to cause each of the $100,000 Subcontracts with the $100,000
Subcontractors to provide, that: (i) the General Contractor and each $100,000
Subcontractor shall leave all common areas (if any) at the Premises affected by
their work in a neat, orderly and safe condition at the end of each day during
construction of the Tenant Improvements; (ii) the General Contractor and each
$100,000 Subcontractor shall procure and maintain the insurance described in
Section 7 below; (iii) to the fullest extent permitted by law, the General
Contractor

                                      -4-


<PAGE>

and each $100,000 Subcontractor shall indemnify, defend (with counsel reasonably
acceptable to Landlord) and hold Landlord and its officers, directors, employees
and contractors harmless from and against any injury or death to any person or
damage to any property in or about the Premises resulting from the activities of
the indemnifying party, except to the extent that such injury, death or damage
results directly from negligence or willful misconduct of Landlord or its
contractors, employees or agents; (iv) the General Contractor and each $100,000
Subcontractor shall guarantee to Tenant for the benefit of Tenant and Landlord
that the portion of the Tenant Improvements for which it is responsible has been
completed in accordance with the Approved Working Drawings and shall be free
from any defects in workmanship and materials for a period of not less than one
(1) year from the date of completion thereof and that the General Contractor and
applicable $100,000 Subcontractor shall be responsible for the replacement or
repair, without additional charge, of all workmanship or materials provided by
the General Contractor pursuant to the Construction Contract or $100,000
Subcontract that may become defective within said one (1)-year period.

     6.   Indemnification. Tenant hereby confirms and agrees that Tenant's
          ---------------
indemnification and defense obligations set forth in Articles 9 and 19 of the
Lease are incorporated in full into this Work Letter as though fully set forth
herein and shall apply to all of Tenant's and the Contractor Group's
construction activities at the Premises and all work related activities
performed at the Premises by or through Tenant and the Contractor Group
hereunder during the Term. Without diminishing Tenant's rights against the
General Contractor or any other member of the Contractor Group, Tenant hereby
assumes all risk of injury or death to persons or damage to property at the
Premises and all costs relating to non-compliance with applicable laws at the
Premises caused by Tenant's construction activities at the Premises, except to
the extent such injury, death or damage is caused by Landlord's or any Landlord
Party's negligence or willful misconduct. The indemnification obligations set
forth in this Section 6 shall not be limited by available insurance proceeds and
shall survive the termination or expiration of the Lease and this Work Letter.

     7.   Insurance. Tenant shall cause Tenant's General Contractor and each
          ---------
member of the Contractor Group to maintain worker's compensation insurance with
statutory benefits and limits. Tenant shall cause Tenant's General Contractor,
and shall exercise commercially reasonable efforts to cause each $100,000
Subcontractor, to maintain comprehensive liability and property damage insurance
in an amount of not less than Two Million Dollars ($2,000,000) per occurrence
($1,000,000 for $100,000 Subcontractors) with companies and on forms reasonably
satisfactory to Landlord in its reasonable discretion. Tenant, the General
Contractor and each $100,000 Subcontractor shall, prior to commencing any work
hereunder and at all times during the entire period of construction of the
Tenant Improvements, keep current and valid certificates of the insurance
required of it hereunder on file with Landlord. Except for worker's compensation
insurance, all policies of insurance shall name Landlord and its respective
directors, officers, employees and agents as additional insureds, provide that
the insurance coverage is primary and noncontributing with any insurance carried
by Landlord, waive subrogation against Landlord with respect to property damage,
cover Tenant's indemnification obligations set forth in Section 6 above and
contain a provision giving Landlord at least thirty (30) days prior written
notice of any cancellation or material change in any insurance coverage.

                                      -5-


<PAGE>

     8.   Builder's Risk Insurance. Tenant, at Tenant's sole cost and expense,
          ------------------------
shall procure and maintain (or cause Tenant's contractor to procure and
maintain) during the construction of the Tenant Improvements Builder's Risk
Insurance covering One Hundred Percent (100%) of the replacement cost of all of
the Tenant Improvements, including all materials and equipment destined to
become part of the Tenant Improvements. Such insurance shall include the perils
of fire, extended coverage, vandalism and malicious mischief, and so-called "All
Risk" perils as defined and limited in the policies, but may, at Tenant's
option, exclude the perils of earthquake and flood. If during the course of
their construction any of the Tenant Improvements are damaged by a casualty
event required to be insured against by Tenant under this Section, Tenant shall
promptly repair such casualty damage (or cause the same to be repaired).

     9.   Landlord's Inspection Rights. During the course of construction of the
          ----------------------------
Tenant Improvements Landlord reserves the right to inspect the progress of the
Tenant Improvements on the terms set forth in Section 16.1 of the Lease;
provided, however, that such inspection(s) shall in no way make Landlord
responsible for any of the work of construction of the Tenant Improvements and,
as more particularly set forth in Section 3.5 above, shall not constitute a
representation or warranty by Landlord as to the design, adequacy or sufficiency
of the Tenant Improvements.

     10.  Notice of Nonresponsibility. Tenant shall give Landlord not more than
          ---------------------------
twenty (20) and not less than ten (10) business days prior written notice of the
date on which the first construction of the Tenant Improvements is scheduled to
commence to permit Landlord to post on the Premises and record with the Santa
Clara County Recorder appropriate notices of nonresponsibility.

     11.  Payments by Tenant; Liens. All costs and expenses relating to the
          -------------------------
Tenant Improvements shall be paid promptly by Tenant as they come due and
evidence of such payment shall be furnished to Landlord upon request. Tenant
shall cause any mechanic's or materialman's lien or other claim filed against
the Premises and relating to the Tenant Improvements to be released and removed
in accordance with the applicable provisions of the Lease notwithstanding any
other dispute Tenant may then have with Landlord. Should Tenant fail to remove
any such lien within the required period of time, Landlord may (at its sole
election) pay or bond over such claim and the amount paid or premium for the
bond, together with any attorneys' fees and costs incurred by Landlord in
connection therewith, shall be immediately due from Tenant to Landlord. Promptly
following completion of any portion of the Tenant Improvements by the General
Contractor and each $100,000 Subcontractor, Tenant shall deliver to Landlord
waivers of mechanic's liens executed by each such person with respect to the
completed portion of such Tenant Improvements. Promptly following completion of
the entire Tenant Improvements, Tenant shall obtain and deliver to Landlord an
unconditional waiver and release upon payment (in the form prescribed by
California Civil Code Section 3262) from the General Contractor and each
$100,000 Subcontractor.

     12.  Notice of Completion; Copy of "As Built" Plans. Within ten (10) days
          ----------------------------------------------
after final completion of construction of the Tenant Improvements, Tenant shall
cause a Notice of Completion to be recorded in the office of the Recorder of the
County of Santa Clara in

                                      -6-
<PAGE>

accordance with Section 3093 of the California Civil Code or any successor
statute, and shall furnish a copy thereof to Landlord upon such recordation. At
the conclusion of construction, (i) Tenant shall cause the Architect and
Contractor (A) to update the Approved Working Drawings as necessary to reflect
all changes made to the Approved Working Drawings during the course of
construction, and (B) to deliver to Landlord two (2) sets of sepias of "record-
set" drawings within ninety (90) days following issuance of a certificate of
occupancy for the Premises, and (ii) Tenant shall deliver to Landlord a copy of
all warranties, guaranties, and operating manuals in Tenant's possession
relating to the Tenant Improvements.

     13.  Compliance with Rules and Regulations. All of Tenant's and the
          -------------------------------------
Contractor Group's activities at the Premises shall comply with any and all
easements, covenants, conditions and restrictions affecting the Premises and any
rules and regulations attached to the Lease.

     14.  Lease Provisions Apply. Nothing in this Work Letter, including
          ----------------------
Tenant's entry into the Premises for construction of the Tenant Improvements
under this Work Letter, shall relieve either Landlord or Tenant from observing
all of the terms, covenants and conditions of the Lease required to be performed
by such party including, without limitation, all indemnification and insurance
provisions of the Lease which shall apply in full to Tenant's construction of
its Tenant Improvements, and all of the provisions of the Lease are hereby
incorporated into and made a part of this Work Letter.

     15.  Landlord's Cooperation. Upon Tenant's request, Landlord shall
          ----------------------
reasonably cooperate with Tenant, at Tenant's sole cost and expense and at no
cost to Landlord, without any liability whatsoever on Landlord's part and
without Landlord having to commit any of its staff or resources, in connection
with Tenant's construction and installation of its Tenant Improvements within
the Premises and Tenant's applications for permits, certificates and approvals
associated therewith.

     16.  No Third Party Beneficiaries. This Work Letter is made and entered
          ----------------------------
into for the sole benefit of Landlord, Tenant, any other party that may be
expressly stated in this Work Letter to benefit for this Work Letter or any
provision hereof, and their respective successors and assigns. No other persons
or entities shall have any rights or benefits under or arising out of this Work
Letter.

       IN WITNESS WHEREOF, Landlord and Tenant have executed this Work Letter as
of the date and year first above written.



LANDLORD:                                    TENANT:


ALZA CORPORATION, a Delaware                 CHEMDEX corporation, a Delaware
corporation                                  corporation


By:   Harold Fethe                           By:  JAMES G. STEWART
      ------------------------------------        -----------------------------

Its:  Sr. Vice Pres., Human Resources        Its: CHIEF FINANCIAL OFFICER
      ------------------------------------        -----------------------------


By:   Peter Staple                           By:  DAVID P. PERRY
      ------------------------------------        -----------------------------

Its:  Sr. Vice President & General Counsel   Its: President & CEO
      ------------------------------------        -----------------------------

                                      -7-
<PAGE>

                   [LETTERHEAD OF WELLS FARGO APPEARS HERE]

                         IRREVOCABLE LETTER OF CREDIT

ALZA Corporation                               Letter of Credit No. NZS330633
950 Page Mill Road                      Date:  August 13, 1999
Palo Alto, CA 94304
Attention: Senior Vice President & General Counsel

Ladies and Gentlemen:

     At the request and for the account of Chemdex Corporation, 3950 Fabian Way,
Palo Alto, CA 94303, we hereby establish our Irrevocable Letter of Credit in
your favor in the amount of One Million Eight Hundred Seventy Five Thousand
United States Dollars (US$1,875,000.00) available with us at our above office by
payment of your draft(s) drawn on us at sight in the form of Exhibit 1 hereto
with the instructions in brackets therein complied with accompanied by your
signed and dated statement in the form of Exhibit 2 hereto with the instructions
in brackets therein complied with.

     Each drawing must also be accompanied by the original of this Letter of
Credit for our endorsement on this Letter of Credit of our payment of such
drawing.

     Partial and multiple drawings are permitted under this Letter of Credit,
however each drawing must be in an amount of not less than US$20,000.00.

     If any instructions accompanying a drawing under this Letter of Credit
request the payment is to be made by transfer to an account with us or at
another bank, we and/or such other bank may rely on an account number specified
in such instructions even if the number identifies a person or entity different
from the intended payee.

     This Letter of Credit expires at our above office on July 31, 2000, but
shall be automatically extended, without written amendment, to July 31 in each
succeeding calendar year up to, but not beyond, April 30, 2005 unless we have
sent written notice to you at your address above by registered mail or express
courier that we elect not to renew this Letter of Credit beyond the date
specified in such notice (the "Non-Renewal Expiration Date"), which Non-Renewal
Expiration Date will be July 31, 2000 or any subsequent July 31 occurring before
April 30, 2005 and be at least 60 calendar days after the date we send you such
notice.

     This Letter of Credit is transferable one or more times, but in each
instance to a single transferee and only in the full amount available to be
drawn under this Letter of Credit at the time of such transfer. Any such
transfer may be effected only through ourselves and only upon presentation to us
at our above-specified office of a duly executed instrument of transfer in the
form attached hereto as Exhibit 3 with the instructions in brackets therein
complied with together with the original of this Letter of Credit. Any transfer
of this Letter of Credit may not change the place of expiration of this Letter
of Credit from our above-specified office. Each transfer shall be evidenced by
our endorsement on the reverse of the original of this Letter of Credit, and we
shall deliver the original of this Letter of Credit so endorsed to the
transferee. All commissions and charges in connection with this transfer are for
the account of Chemdex Corporation.
<PAGE>

This is an integral part of Wells Fargo Bank, N.A. Letter of Credit No.
NZS330633

                                                            Page Two

     This Letter of Credit is subject to the Uniform Customs and Practice for
Documentary Credits (1993 revision), International Chamber of Commerce
Publication No. 500, and engages us in accordance therewith.

                                             Very truly yours,

                                             WELLS FARGO BANK N.A.

                                        BY: /s/ [ILLEGIBLE]^^
                                            -----------------------------
                                             (AUTHORIZED SIGNATURE)
<PAGE>

                                                 Exhibit 1
                                                 Wells Fargo Bank, N.A
                                                 Letter of Credit No. NZS330633

================================================================================

Wells Fargo Bank, N.A.
Trade Services Division, Northern California
525 Market Street
San Francisco, CA 94105

Attention: Manager, Standby Letter of Credit Dept.

                                     DRAFT

                                              Date of Draft: [insert date]

          To the order of [insert Beneficiary Name], pay [insert amount of
drawing in words] UNITED STATES DOLLARS (U.S. $ [insert amount of drawing in
numbers]) at sight

          For value received under Letter of Credit No. NZS330633

          "Drawn under Wells Fargo Bank, N.A. Letter of Credit No. NZS330633
dated August 13, 1999."


                                              [insert Beneficiary Name]

                                              By: [insert signature]
                                              Its: [insert title]

================================================================================
<PAGE>

                                                  Exhibit 2
                                                  Wells Fargo Bank, N.A
                                                  Letter of Credit No. NZS330633

================================================================================

Wells Fargo Bank, N.A.
Trade Services Division, Northern California
525 Market Street
San Francisco, CA 94105

Attention: Manager, Standby Letter of Credit Dept.

     Re: Letter of Credit No. NZS330633

Ladies and Gentlemen:

     1.   The undersigned Beneficiary, [insert Beneficiary Name], is Landlord
under that certain Office Lease dated August 13, 1999 ("Lease") with Chemdex
Corporation, a Delaware corporation, as Tenant.

     2.   The undersigned Beneficiary is entitled to payment under the Lease in
the amount of U.S.$[insert amount of draft which accompanies this statement]
(the "Draw Amount") in accordance with the applicable provisions of the Lease
(as the same may have been amended to date), which is the same amount as the
Draft accompanying this Certificate and is less than or equal to the amount
currently available under the Letter of Credit.

     3.   The individual executing this Certificate on behalf of Beneficiary is
a duly authorized officer of Beneficiary.


Date: [insert date]                           [insert Beneficiary Name]

                                              By: [insert signature]
                                              Its: [insert title]

================================================================================
<PAGE>

                                                  Exhibit 3
                                                  Wells Fargo Bank, N.A
                                                  Letter of Credit No. NZS330633

================================================================================

                                                   Date: [insert date]

Wells Fargo Bank, N.A.
Trade Services Division, Northern California
525 Market Street, 25th Floor
San Francisco, California 94105
Attention: Manager, Standby Letter of Credit Department

Subject: Your Letter of Credit No. NZS330633

Ladies and Gentlemen:

     For value received, we hereby irrevocably assign and transfer all our
rights under the above-captioned Letter of Credit, as heretofore and hereafter
amended, extended or increased, to:

               ____________________________
               [ insert Name of Transferee]

               ____________________________

               ____________________________
               [ insert Address of Transferee]

     By this transfer, all of our rights in the Letter of Credit are transferred
to the transferee, and the transferee shall have sole rights as beneficiary
under the Letter of Credit, including sole rights relating to any amendments,
whether increases or extensions or other amendments, and whether now existing or
hereafter made. You are hereby irrevocably instructed to advise future
amendment(s) of the Letter of Credit to the transferee without our consent or
notice to us.

     You are hereby advised that [ insert Name of Transferee] succeeded to all
of beneficiary's right, title and interest under that certain Office Lease dated
August 13, 1999 (as the same may have been amended to date), with Chemdex
Corporation, a Delaware corporation, as Tenant.

     Enclosed are the original Letter of Credit and the original of all
amendments to this date. Please notify the transferee of this Transfer and of
the terms and conditions of the Letter of Credit as transferred. All fees and
charges in connection with this Transfer are for the account of Chemdex
Corporation.

                                         Very truly yours,

                                         [Insert Name of Beneficiary]

                                         By: [insert signature]
                                         Its: [insert title]

Signature of Transferor Guaranteed
[Insert Name of Bank]
By: [insert signature]
Name: [insert typed or printed name]
Title: [insert title]

================================================================================
<PAGE>

to benefit for this Work Letter or any provision hereof, and their respective
successors and assigns. No other persons or entities shall have any rights or
benefits under or arising out of this Work Letter.

          IN WITNESS WHEREOF, Landlord and Tenant have executed this Work Letter
as of the date and year first above written.


LANDLORD:                                  TENANT:

ALZA CORPORATION, a Delaware               CHEMDEX corporation, a Delaware

corporation                                corporation


By:     /s/ Harold Fethe                   By:     /s/ James G. Stewart
     ------------------------------------       --------------------------------
            Harold Fethe                               JAMES G. STEWART
Its: Sr. Vice Pres., Human Resources       Its: CHIEF FINANCIAL OFFICER
     ------------------------------------       --------------------------------


By:     /s/ Peter Staple                   By:     /s/ David P. Perry
     ------------------------------------       --------------------------------
            Peter Staple                               DAVID P. PERRY
Its: Sr. Vice President & Gen. Counsel     Its: President & CEO
     ------------------------------------       --------------------------------

                                      -8-
<PAGE>

                                   EXHIBIT E
                                   ---------

                TERMS TO BE INCORPORATED IN LEASE SUBORDINATION,
                    ATTORNMENT AND NONDISTURBANCE AGREEMENT

     THIS AGREEMENT is made this _______ day of ____________________, by and
between CHEMDEX CORPORATION, a Delaware Corporation ("Tenant") and ____________
_________________________ ("Lender"):


                                    RECITALS

     A. Lender is the holder of that certain promissory note ("Note") issued by
ALZA CORPORATION ("Landlord") dated ____________________ in the principal sum of
_______________________ DOLLARS ($_____________)and of the deed of trust
recorded on ________________ ("Mortgage"), which Mortgage encumbers the real
property (the "Mortgaged Property") commonly known as 1500 Plymouth Street and
1550 Plymouth Street, Mountain View, California, which Mortgaged Property is
more particularly described in the Mortgage.


     B. Landlord and Tenant entered into that certain Office Lease ("Lease")
dated August 13, 1999, by which Tenant leased from Landlord the Mortgaged
Property, all as more fully described in the Lease.

     C. Tenant desires to be able to obtain the advantages of the Lease and
occupancy thereunder in the event of foreclosure of the Mortgage and Lender
wishes to have Tenant confirm the priority of the Mortgage over the Lease as the
Lease relates to the Mortgaged Property.

     NOW, THEREFORE, in consideration of the mutual covenants and conditions set
forth hereinbelow, the parties hereto agree as follows:

     1. Tenant hereby covenants and agrees that all its rights, title and
interest whatsoever under the Lease as the Lease relates to the Mortgaged
Property is and shall at all times be and remain unconditionally subject and
subordinate to lien and charge of the Mortgage and to all the terms, conditions
and provisions thereof, to all advances made or to be made thereunder or under
the Note, and to any increases, renewals, extensions, modifications,
substitutions, consolidations or replacements thereof or of the Note and the
Mortgage.

     2. So long as Tenant is not in default (beyond any period given Tenant in
the Lease to cure such defaults) in the payment of rent or additional charges or
in the performance of any of the other terms, covenants or conditions of the
Lease on Tenant's part to be performed, Tenant shall not be disturbed by Lender
in its possession of the Mortgaged Property during the term of the Lease, or any
extension or renewal thereof, or in the enjoyment of its rights under the Lease.

     3. If the interest of the Landlord under the Lease as the Lease relates to
the Mortgaged Property shall be acquired by Lender or any purchaser
("Purchaser") by reason of exercise of the power of sale or the foreclosure of
the Mortgage or other proceedings brought to enforce the rights of the holder
thereof, by deed in lieu of foreclosure or by any other method, and Lender or

                                      -1-
<PAGE>

Purchaser succeeds to the interest of Landlord under the Lease, Tenant shall
attorn to Lender or Purchaser as its landlord, said attornment to be effective
and self-operative without the execution of any other instruments on the part of
either party hereto immediately upon Lender's or Purchaser's succeeding to the
interest of the Landlord under the Lease, and the Lease shall continue in
accordance with its terms between Tenant as tenant and Lender or Purchaser as
landlord, provided however that:

          (a) Lender shall not be personally liable under the Lease and Lender's
liability under the Lease shall be limited to the equity interest of Lender in
the Mortgaged Property as provided in Section 25.3 of the Lease;

          (b) Lender shall not be liable for any act or omission of any prior
landlord (including Landlord);

          (c) Lender shall not be subject to any offsets or defenses which
Tenant might have against any prior landlord (including Landlord);

          (d) Lender shall not be liable for any damages or other relief
attributable to any prior latent defects in the Mortgaged Property; and

          (e) Lender shall not be bound by any prepayment of rent, additional
rent or deposit, rental security, letter of credit or any other sums deposited
with any prior landlord (including Landlord) under the Lease unless actually
received by Lender.

     4. Tenant certifies to Lender that except as provided below, (i) the Lease
is presently in full force and effect with no defaults thereunder by Landlord or
by Tenant and unmodified; (ii) the term thereof has commenced and the full
rental is now accruing thereunder, (iii) Tenant has accepted possession of the
Premises and that any improvements required by the terms of the Lease to be made
by Landlord have been completed to the satisfaction of Tenant; (iv) no rent
under the Lease has been paid more than thirty (30) days in advance of its due
date; (v) the address for notices to be sent to Tenant is as set forth in the
Lease; and (vi) Tenant has no charge, lien, claim or offset under the Lease or
otherwise, against rents or other charges due or to become due thereunder.

     5. Tenant agrees with Lender that from and after the date hereof, Tenant
will not terminate or seek to terminate the Lease by reason of my act or
omission of Landlord thereunder until Tenant shall have given written notice, by
registered or certified mail, return receipt requested, of said act or omission
to Lender, which notice shall be addressed to Lender and until the grace period
as set forth in the Lease shall have elapsed following the giving of such
notice, during which period Lender shall have the right, but shall not be
obligated, to remedy such act or omission.

     6. Nothing in this Agreement shall be deemed to be or construed to be an
agreement by Lender to perform any covenant of Landlord under the Lease unless
and until it obtains title to the Mortgaged Property by power of sale or
judicial foreclosure or deed in lieu thereof or obtains possession of the
Property pursuant to the terms of the Mortgage.

                                      -2-
<PAGE>

     7. This Agreement shall inure to the benefit of and shall be binding upon
Tenant and Lender, and their respective heirs, personal representatives,
successors and assigns. This Agreement may not be altered, modified or amended
except in writing signed by all of the parties hereto. In the event any one or
more of the provisions contained in this Agreement shall for any reason be held
to be invalid, illegal or unenforceable in any respect, such invalidity,
illegality or unenforceability shall not affect any other provisions of this
Agreement, but this Agreement shall be construed as if such invalid, illegal or
unenforceable provision had never been contained herein. This Agreement shall be
governed by and construed according to the laws of the State of California.

     IN WITNESS WHEREOF, Lender and Tenant have executed this Agreement as of
the date and year first above written.


LENDER:                             TENANT:
                                    CHEMDEX CORPORATION, a
                                    Delaware Corporation


By:__________________________       By:______________________________

Its:_________________________       Its:_____________________________

                                      -3-
<PAGE>

                                    SCHEDULE 2

                     List of Groundwater Monitoring Reports

     1. Letter dated May 15, 1998 from the San Francisco Bay Regional Water
Quality Control Board to ALZA Corporation concerning 1500/1550 Plymouth Street,
Mountain View.

     2. Letter and Summary of Environmental Condition dated June 17, 1999 from
Aquifer Services, Inc. to ALZA Corporation concerning 1500/1550 Plymouth Street
and 1010 Joaquin Road, Mountain View.

     3. Groundwater Monitoring Report for the Quarterly Reporting Period January
1 through March 31, 1999 prepared for Spectra-Phipers Lasers, Inc. and Teledyne
Semiconductor dated April 30, 1999.

                                      -1-
<PAGE>

                          Building M6A - First Floor

                                 [Floor Plan]
<PAGE>

                          Building M6A - Second Floor

                                 [Floor Plan]
<PAGE>

                          Building M6B - First Floor

                                 [Floor Plan]
<PAGE>

                          Building M6B - Second Floor

                                 [Floor Plan]
<PAGE>
8PAGE>

                           Estimated Furniture Value
                              in Bldgs. M6A, M6B

<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------------------
             Description                     Brand            Quantity       New Cost Ea        Cost Total
- -----------------------------------------------------------------------------------------------------------
<S>                                  <C>                      <C>            <C>                <C>
- -----------------------------------------------------------------------------------------------------------
   Bookcase: Short 42" - 48"         Various Laminate               21        $   260.00        $  5,460.00
- -----------------------------------------------------------------------------------------------------------
   Bookcase: Short 42" - 48"         Various Metal                  18        $   180.00        $  3,240.00
- -----------------------------------------------------------------------------------------------------------
   Bookcase: Short 42" - 48"         Various Wood                   31        $   550.00        $ 17,050.00
- -----------------------------------------------------------------------------------------------------------
   Bookcase: Tall 55" - 72"          Various Laminate               11        $   350.00        $  3,850.00
- -----------------------------------------------------------------------------------------------------------
   Bookcase: Tall 55" - 72"          Various Metal                  18        $   225.00        $  4,050.00
- -----------------------------------------------------------------------------------------------------------
   Bookcase: Tall 55" - 72"          Various Wood                   17        $   950.00        $ 16,150.00
- -----------------------------------------------------------------------------------------------------------
   Cabinet, Metal Utility            Various                        10        $   450.00        $  4,500.00
- -----------------------------------------------------------------------------------------------------------
   Cabinet, Wood                     Various                         4        $ 1,200.00        $  4,800.00
- -----------------------------------------------------------------------------------------------------------
   Chair, Conf Room                  Various                        66        $   500.00        $ 33,000.00
- -----------------------------------------------------------------------------------------------------------
   Chair, Exec                       Various                         6        $   800.00        $  4,800.00
- -----------------------------------------------------------------------------------------------------------
   Chair, Side                       Various                       195        $   300.00        $ 58,500.00
- -----------------------------------------------------------------------------------------------------------
   Chair, Side: Wood                 Steelcase                      24        $   240.00        $  5,760.00
- -----------------------------------------------------------------------------------------------------------
   Chair, Lobby                      Various                         4        $   600.00        $  2,400.00
- -----------------------------------------------------------------------------------------------------------
   Chair, Lunch Room                 Various                        35        $   180.00        $  6,300.00
- -----------------------------------------------------------------------------------------------------------
   Chair, Task                       Steelcase Criterion           113        $   500.00        $ 56,500.00
- -----------------------------------------------------------------------------------------------------------
   Chair, Task                       H.Miller Aeron                  9        $   800.00        $  7,200.00
- -----------------------------------------------------------------------------------------------------------
   Chair, Task                       Various                       420        $   500.00        $ 10,000.00
- -----------------------------------------------------------------------------------------------------------
   Credenza, Laminate                Various                         9        $   550.00        $  4,950.00
- -----------------------------------------------------------------------------------------------------------
   Credenza, Wood                    Various                        35        $   850.00        $ 29,750.00
- -----------------------------------------------------------------------------------------------------------
   Cubicle, approx 8'x10'            Steelcase 9000                123        $ 6,000.00        $ 38,000.00
- -----------------------------------------------------------------------------------------------------------
   Desk, 3-Part Laminate             Sequus                         46        $ 1,200.00        $ 55,200.00
- -----------------------------------------------------------------------------------------------------------
   Desk, Laminate                    Various                        31        $   550.00        $ 17,050.00
- -----------------------------------------------------------------------------------------------------------
   Desk, Large Wood                  Various                        10        $   650.00        $  6,500.00
- -----------------------------------------------------------------------------------------------------------
   Desk, Metal w/Wood Dbl Ped        Various                        52        $   800.00        $ 41,600.00
- -----------------------------------------------------------------------------------------------------------
   Desk, w/Return                    Steelcase 9000                 60        $ 1,630.00        $ 97,800.00
- -----------------------------------------------------------------------------------------------------------
   Desk, w/Return                    Various Wood/Metal             23        $   500.00        $ 11,500.00
- -----------------------------------------------------------------------------------------------------------
   Desk, Wood, Exec                  Steelcase                      29        $ 2,500.00        $ 72,500.00
- -----------------------------------------------------------------------------------------------------------
   Desk, Wood, Small                 Various                        44        $   700.00        $ 30,800.00
- -----------------------------------------------------------------------------------------------------------
   File Cabinet, 2-Drawer            Various                       113        $   365.00        $ 41,245.00
- -----------------------------------------------------------------------------------------------------------
   File Cabinet, 3-Drawer            Various                        29        $   500.00        $ 14,500.00
- -----------------------------------------------------------------------------------------------------------
   File Cabinet, 4-Drawer            Various                       145        $   800.00        $ 16,000.00
- -----------------------------------------------------------------------------------------------------------
   File Cabinet, 5-Drawer            Various                        48        $ 2,500.00        $ 20,000.00
- -----------------------------------------------------------------------------------------------------------
   File Cabinet, Vertical            Various                         5        $   250.00        $  1,250.00
- -----------------------------------------------------------------------------------------------------------
   File Cabinet High Density         Various Metal                  17        $ 2,500.00        $ 42,500.00
- -----------------------------------------------------------------------------------------------------------
   File Cabinet Misc                 Various                        48        $   300.00        $ 14,400.00
- -----------------------------------------------------------------------------------------------------------
   File Cabinet 4-Dr Fire-Proof      Fire-King                       2        $ 4,000.00        $  8,000.00
- -----------------------------------------------------------------------------------------------------------
   File, Flat                        Wood                            2        $ 2,500.00        $  5,000.00
- -----------------------------------------------------------------------------------------------------------
   Keyboard Trays                    WorkRite (85%)                367        $   200.00        $ 73,400.00
- -----------------------------------------------------------------------------------------------------------
   Safe, Small                       Various                         2        $ 1,500.00        $  3,000.00
- -----------------------------------------------------------------------------------------------------------
   Server Room Racking               Wrightline                      2        $12,000.00        $ 24,000.00
- -----------------------------------------------------------------------------------------------------------
   Sofa, Sectional                   Generic                         1        $ 6,000.00        $ 25,000.00
- -----------------------------------------------------------------------------------------------------------
   Table, Computer                   Human Factor                    8        $   850.00        $  6,800.00
- -----------------------------------------------------------------------------------------------------------
   Table, Computer                   Various                        22        $   350.00        $  7,700.00
- -----------------------------------------------------------------------------------------------------------
   Table, Conference Room            Various                         5        $ 5,000.00        $ 25,000.00
- -----------------------------------------------------------------------------------------------------------
   Table, Large Round                Various                        29        $   750.00        $ 21,750.00
- -----------------------------------------------------------------------------------------------------------
   Table, Lunch                      Laminate/Metal                  4        $   450.00        $  1,800.00
- -----------------------------------------------------------------------------------------------------------
   Table, Misc                       Various                        66        $   300.00        $ 19,800.00
- -----------------------------------------------------------------------------------------------------------
</TABLE>
                       Estimated Furniture Value
August 13, 1999           in Bldgs. M6A, MGB

<PAGE>

                           Estimated Furniture Value
                              in Bldgs. M6A, M6B

<TABLE>
<S>                                  <C>                            <C>         <C>         <C>
   Table, Printer/Computer           Various                        11          $250.00     $    2,750.00
- ---------------------------------------------------------------------------------------------------------
   Table, Small Round                Various                        50          $265.00     $   13,250.00
- ---------------------------------------------------------------------------------------------------------
   Table, Task 30x60                 Various                        16          $350.00     $    5,600.00
- ---------------------------------------------------------------------------------------------------------
   Table, Training                   Various                        23          $650.00     $   14,950.00
- ---------------------------------------------------------------------------------------------------------
                                                                                            $2,156,905.00
                                                                                            =============
- ---------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------
</TABLE>

                           Estimated Furniture Value
August 13, 1999               in Bldgs. M6A, M6B                               2



<PAGE>
                                                                   EXHIBIT 10.23
                               VOTING AGREEMENT

     THIS VOTING AGREEMENT (this "Agreement") is made and entered into as of
September 21, 1999, between Chemdex Corporation ("Chemdex"), a Delaware
corporation, and the undersigned stockholder (the "Stockholder") of
Promedix.com, Inc., a Delaware corporation ("Promedix").

                                   RECITALS

     A.   Concurrently with the execution of this Agreement, Chemdex, Promedix
and Popcorn Acquisitions Corp., a Delaware corporation and wholly-owned
subsidiary of Chemdex ("Merger Sub"), have entered into an Agreement and Plan of
Merger (the "Merger Agreement"), which provides for the merger (the "Merger") of
Merger Sub with and into Promedix and the conversion of each outstanding share
of Promedix's capital stock into shares of Chemdex Common Stock.

     B.   As a condition to its willingness to enter into the Merger Agreement,
Chemdex has requested that the Stockholder agree to certain matters regarding
the retention and voting of the Shares (as defined below) in connection with the
Merger.

                                   AGREEMENT

     The parties agree as follows:

     1.   Agreement to Retain Shares.
          --------------------------

          1.1  Transfer and Encumbrance.  The Stockholder agrees not to
               ------------------------
transfer, sell, exchange, pledge or otherwise dispose of or encumber (in each
case, other than as a result of death) any shares of capital stock of Promedix
owned or beneficially held by him (the "Shares") or New Shares, as defined in
Section 1.2 below, or to make any offer or agreement relating thereto, at any
time prior to the Expiration Date.  As used herein, the term "Expiration Date"
shall mean the earlier to occur of (i) such date and time as the Merger shall
become effective in accordance with the terms and provisions of the Merger
Agreement, or (ii) the date on which the Merger Agreement shall be terminated in
accordance with Section 9.1 thereof.

          1.2  Additional Purchases.  The Stockholder agrees that any shares of
               --------------------
capital stock of Promedix that such Stockholder shall purchase or with respect
to which such Stockholder shall otherwise acquire beneficial ownership after the
execution of this Agreement and prior to the Expiration Date (the "New Shares")
shall be subject to the terms and conditions of this Agreement to the same
extent as if they constituted Shares.

     2.   Agreement to Vote Shares and Grant Proxy.  At every meeting of the
          ----------------------------------------
stockholders of Promedix called with respect to any of the following, and on
every action or approval by written consent of the stockholders of Promedix with
respect to any of the following, the Stockholder agrees to vote the Shares and
any New Shares in favor of approval of the Merger Agreement and the Merger and
any matter that could reasonably be expected to facilitate the

                                      -1-
<PAGE>

Merger, including the manner in which the Escrow Fund under the Merger Agreement
is to be established as contemplated by Section 2.2 and Article X of the Merger
Agreement. The Stockholder further agrees not, directly or indirectly, to
solicit or encourage any offer from any party concerning the possible
disposition of all or any substantial portion of Promedix's business, assets or
capital stock. In the event Promedix's board of directors does not call a
meeting to approve the Merger, the Stockholder agrees to take all action
necessary to call a meeting to approve the Merger or to approve the Merger by
written consent. In order to effectuate the foregoing, the Stockholder does
hereby constitute and appoint Chemdex, or any nominee of Chemdex, with full
power of substitution, from the date hereof to the Expiration Date, as its true
and lawful proxy, for and in its name, place and stead, including the right to
sign its name (as stockholder) to any consent, certificate or other document
relating to Promedix, for the sole purpose of causing the Shares and any New
Shares to be voted in the manner contemplated by this Section 2. The parties
acknowledge that the proxy provided for here is irrevocable and coupled with an
interest.

     3.   Representations, Warranties and Covenants of the Stockholder.  The
          ------------------------------------------------------------
Stockholder represents, warrants and covenants to Chemdex as follows:

          3.1  Ownership of Shares.  The Stockholder (together with such
               -------------------
Stockholder's spouse, if applicable) is the sole beneficial and record owner and
holder of the Shares, which at the date hereof and at all times up until the
Expiration Date, will be free and clear of any liens, claims, options, charges,
security interests, equities, options, warrants, rights to purchase (including,
without limitation, restrictions on rights of disposition other than those
imposed by applicable securities laws), third party rights of any nature or
other encumbrances; and (ii) does not own any shares of capital stock of
Promedix other than the Shares.

          3.2  Authority; Due Execution.  The Stockholder has full power and
               ------------------------
authority to make, enter into and carry out the terms of this Agreement.  The
Stockholder has duly executed and delivered this Agreement and (assuming the due
authorization, execution and delivery of this Agreement by Chemdex) this
Agreement constitutes a valid and binding obligation of the Stockholder.

     4.   Representations, Warranties and Covenants of Chemdex.  Chemdex
          ----------------------------------------------------
represents, warrants and covenants to the Stockholder as follows:

          4.1  Due Authorization.  This Agreement has been authorized by all
               -----------------
necessary corporate action on the part of Chemdex and has been duly executed by
a duly authorized officer of Chemdex.

          4.2  Validity; No Conflict.  This Agreement constitutes the legal,
               ---------------------
valid and binding obligation of Chemdex.  Neither the execution of this
Agreement by Chemdex nor the consummation of the transactions contemplated
hereby will result in a breach or violation of the terms of any agreement by
which Chemdex is bound or by any decree, judgment, order, law or regulation now
in effect of any court or other governmental body applicable to Chemdex.

                                      -2-
<PAGE>

     5.   Termination.  This Agreement shall terminate and shall have no further
          -----------
force or effect as of the Expiration Date.

     6.   Miscellaneous.
          -------------

          6.1  Severability.  If any term, provision, covenant or restriction of
               ------------
this Agreement is held by a court of competent jurisdiction to be invalid, void
or unenforceable, then the remainder of the terms, provisions, covenants and
restrictions of this Agreement shall remain in full force and effect and shall
in no way be affected, impaired or invalidated.

          6.2  Binding Effect and Assignment.  This Agreement and all of the
               -----------------------------
provisions hereof shall be binding upon and inure to the benefit of the parties
hereto and their respective successors and permitted assigns, but, except as
otherwise specifically provided herein, neither this Agreement nor any of the
rights, interests or obligations of the parties hereto may be assigned by either
of the parties without the prior written consent of the other.

          6.3  Amendments and Modification.  This Agreement may not be modified,
               ---------------------------
amended, altered or supplemented except upon the execution and delivery of a
written agreement executed by the parties hereto.

          6.4  Specific Performance; Injunctive Relief.  The parties hereto
               ---------------------------------------
acknowledge that Chemdex will be irreparably harmed and that there will be no
adequate remedy at law for a violation of any of the covenants or agreements of
the Stockholder set forth herein. Therefore, it is agreed that, in addition to
any other remedies that may be available to Chemdex upon any such violation,
Chemdex shall have the right to enforce such covenants and agreements by
specific performance, injunctive relief or by any other means available to
Chemdex at law or in equity.

          6.5  Governing Law.  This Agreement shall be governed by, construed
               -------------
and enforced in accordance with, the internal laws of the State of Delaware as
such laws are applied to contracts entered into and to be performed entirely
within Delaware.

          6.6  Entire Agreement.  This Agreement contains the entire
               ----------------
understanding of the parties in respect of the subject matter hereof, and
supersedes all prior negotiations and understandings between the parties with
respect to such subject matter.

          6.7  Notices.  Any notice or other communication required or permitted
               -------
to be delivered under this Agreement shall be in writing and shall be deemed
properly delivered, given and received when delivered (by hand, by registered
mail, by courier or express delivery service or by facsimile confirmation) to
the address or facsimile telephone number set forth beneath the name of such
party below (or to such other address or facsimile telephone number as such
party shall have specified in a written notice given to the other party):

     If to Chemdex:      Chemdex
                         3950 Fabian Way
                         Palo Alto, CA 94308

                                      -3-
<PAGE>

                         Attention: Chief Executive Officer
                         Telephone No.: (650) 813-0300
                         Telecopy No.:  (650) 813-0304

     with a copy at the same address to the attention of the General Counsel and
     Secretary and with a copy to:

                         Venture Law Group
                         A Professional Corporation
                         2800 Sand Hill Road
                         Menlo Park, California 94025
                         Attention:  Steven J. Tonsfeldt
                         Telephone No.: (650) 854-4488
                         Telecopy No.:  (650) 233-8386

     If to Stockholder:

     at the address or facsimile phone number set forth below Stockholder's
     signature on the signature page hereof.

     With a copy to:     Orrick, Herrington & Sutcliffe LLP
                         1020 Marsh Road
                         Menlo Park, CA 94025
                         Attention: Geoffrey P. Leonard, Esq.
                         Telephone No.: (650) 614-7470
                         Telecopy No.:  (650) 614-7401

          6.8  Counterparts.  This Agreement may be executed in several
               ------------
counterparts, each of which shall be an original, but all of which together
shall constitute one and the same agreement.

          6.9  Effect of Headings.  The section headings herein are for
               ------------------
convenience only and shall not affect the construction or interpretation of this
Agreement.

          6.10 No Limitation on Actions of the Stockholder as Director.  In the
               -------------------------------------------------------
event the Stockholder is a director of Promedix, notwithstanding anything to the
contrary in this Agreement, nothing in this Agreement is intended or shall be
construed to require the Stockholder to take or in any way limit any action that
the Stockholder may take to discharge the Stockholder's fiduciary duties as a
director of Promedix.

                            [Signature Page Follows]

                                      -6-
<PAGE>

          IN WITNESS WHEREOF, the parties have caused this Voting Agreement to
be duly executed on the day and year first written above.


                              CHEMDEX CORPORATION

                              By: /s/ David P. Perry
                                 ------------------------------------

                              Name: David Perry
                                   ----------------------------------

                              Title:      CEO
                                    ---------------------------------


                              STOCKHOLDER


                                   /s/ W.C Klintworth, Jr
                              ---------------------------------------


                              Name:         W.C Klintworth, Jr
                                   ----------------------------------

                                      -5-
<PAGE>

          IN WITNESS WHEREOF, the parties have caused this Voting Agreement to
be duly executed on the day and year first written above.


                              CHEMDEX CORPORATION

                              By: ___________________________________

                              Name: _________________________________

                              Title: ________________________________


                              STOCKHOLDER


                                   /s/ Ed Kuklenske,
                              ---------------------------------------


                              Name:        Ed Kuklenske
                                   ----------------------------------

                                      -6-
<PAGE>

          IN WITNESS WHEREOF, the parties have caused this Voting Agreement to
be duly executed on the day and year first written above.


                              CHEMDEX CORPORATION

                              By: ___________________________________

                              Name: _________________________________

                              Title: ________________________________


                              STOCKHOLDER


                                   /s/ Barrie Brewer,
                              ---------------------------------------


                              Name:       Barrie Brewer
                                   ----------------------------------

                                      -7-
<PAGE>

          IN WITNESS WHEREOF, the parties have caused this Voting Agreement to
be duly executed on the day and year first written above.


                              CHEMDEX CORPORATION

                              By: __________________________________

                              Name: ________________________________

                              Title: _______________________________


                              STOCKHOLDER


                                   /s/ Peter Mills @ Ventures III, L.P
                              ----------------------------------------------


                              Name:          Peter Mills
                                   -----------------------------------------

                                      -8-
<PAGE>

          IN WITNESS WHEREOF, the parties have caused this Voting Agreement to
be duly executed on the day and year first written above.


                              CHEMDEX CORPORATION

                              By: _______________________________

                              Name: _____________________________


                              Title: ____________________________



                              STOCKHOLDER


                                   /s/ J. Benear,
                              -----------------------------------


                              Name: John B. Benear
                                   ------------------------------

                                      -9-

<PAGE>

                                                                   EXHIBIT 10.24


                              CHEMDEX CORPORATION
                                3950 Fabian Way
                              Palo Alto, CA 94303

                              September 21, 1999

William C. Klintworth
c/o Promedix, Inc.
448 East Winchester Avenue, Suite 200
Salt Lake City, UT 84107


Dear Skip:

In connection with the proposed acquisition of Promedix.com, Inc. ("Promedix")
pursuant to that Agreement and Plan of Merger dated as of September 21, 1999
(the "Merger Agreement"), Chemdex Corporation  (the "Company") is pleased to
offer you employment on the following terms:

Position.  You will serve in a full-time capacity as Chief Executive Officer of
- --------
the Promedix.com subsidiary of the Company. You will report to the Chief
Executive Officer of the Company. Your role at the present time includes
responsibility for the Promedix subsidiary.

Cash Compensation.  You will be paid a monthly salary of not less than $12,500,
- -----------------
which is equivalent to $150,000 on an annual basis, payable in semi-monthly
installments in accordance with the Company's standard payroll practices for
salaried employees.

Proprietary Information and Inventions Agreement.  Like all Company employees,
- ------------------------------------------------
you will be required, as a condition to your employment with the Company, to
sign the Company's standard Employee Confidentiality and Inventions Agreement, a
copy of which is attached hereto as Exhibit A.

Change of Control Agreement.  You will be entitled to enter into the standard
- ---------------------------
Change of Control Agreement for the Company's officers in the form attached
hereto as Exhibit B.

Noncompetition Agreement.  As a condition to the Company's entrance into the
- ------------------------
Merger Agreement and the consummation of the transactions contemplated in the
Merger Agreement, you will be required to execute the Noncompetition Agreement
in the form attached hereto as Exhibit C.

Stock Restriction Agreement. As a condition to the Company's entrance into the
- ---------------------------
Merger Agreement and the consummation of the transactions contemplated in the
Merger Agreement, you will be required to execute the Stock Restriction
Agreement in the form attached hereto as Exhibit D.

                                      -1-
<PAGE>

Period of Employment.  Your employment with the Company will commence
- --------------------
immediately after the consummation of the transactions contemplated by the
Merger Agreement. Your employment with the Company will be "at will," meaning
that either you or the Company will be entitled to terminate your employment at
any time and for any reason, with or without cause. Any contrary representations
which may have been made to you are superseded by this offer. This is the full
and complete agreement between you and the Company on this term. Although your
job duties, title, compensation and benefits, as well as the Company's personnel
policies and procedures, may change from time to time, the "at will" nature of
your employment may only be changed in an express written agreement signed by
you and a duly authorized officer of the Company.

Severance. In the event your employment with the Company is either terminated by
- ---------
the Company without Cause or as a result of a Constructive Termination during
the first year following the closing of the transactions contemplated by the
Merger Agreement, your Company stock and options will immediately vest in full.
After the initial one-year period, if your employment with the Company is either
terminated by the Company without Cause or as a result of a Constructive
Termination, your Company stock and options shall become vested on the effective
date of such termination as if you had been employed by the Company for an
additional twelve months following such termination.  In addition, in the event
your employment with the Company is either terminated by the Company without
Cause or as a result of a Constructive Termination at any time, you will be paid
an amount equal to the greater of (i) six (6) months of your then-current
salary, or (ii) $100,000, in each case payable in twelve (12) equal semi-monthly
installments in accordance with the Company's standard payroll practices for
salaried employees.  In return for these severance benefits, you agree that you
will: (a) sign an agreement releasing the Company and its officers, directors,
stockholders and employees from any and all employment-related claims with
standard provisions for agreements of this type; (b) reaffirm that you are bound
by the provisions of your Employee Confidentiality Agreement and other
agreements between you and the Company, including any Noncompetition Agreement;
(c) not make any disparaging remarks about the Company or its officers,
directors, employees, products or business practices.

"Cause" means (a) willful and repeated failure to comply with the lawful
directions of the Board, (b) gross negligence or willful misconduct in the
performance of your duties to the Company, (c) commission of any act of fraud
against, or the misappropriation of material property belonging to, the Company
or (d) conviction of a crime that is materially injurious to the business or
reputation of the Company, in each case as determined in good faith by the
Board.

"Constructive Termination" means your voluntary termination, upon 30 days prior
written notice to the Company, following (a) a material reduction or change in
your job duties, responsibilities and requirements inconsistent with your
position with the Company and your prior duties, responsibilities and
requirements; (b) any reduction of greater than 5% in your base compensation
(including salary, benefits, incentive payments and bonuses), other than in
connection with a general decrease in base salaries for most officers of the
Company and any

                                      -2-
<PAGE>

successor corporation; or (d) your refusal to relocate to a facility or location
more than 50 miles from the current location of the Promedix.com subsidiary.

Proof of Right to Work. For purposes of federal immigration law, you will be
- ----------------------
required to provide to the Company documentary evidence of your identity and
eligibility for employment in the United States.  Such documentation must be
provided to us within three (3) business days of your date of hire, or our
employment relationship with you may be terminated and, in such event, you would
not be entitled to the severance payment set forth in the preceding paragraph.

Withholding Taxes.  All forms of compensation referred to in this letter are
- -----------------
subject to reduction to reflect applicable withholding and payroll taxes.

Entire Agreement.  This letter and the Exhibits attached hereto contain all of
- ----------------
the terms of your employment with the Company and supersede any prior
understandings or agreements, whether oral or written, between you and the
Company.

Amendment and Governing Law.  This letter agreement may not be amended or
- ---------------------------
modified except by an express written agreement signed by you and a duly
authorized officer of the Company.  The terms of this letter agreement and the
resolution of any disputes will be governed by California law, except as
provided in the Noncompetition Agreement.

We hope that you find the foregoing terms acceptable. You may indicate your
agreement with these terms and accept this offer by signing and dating the
enclosed duplicate original of this letter and the enclosed Exhibits and
returning them to me.


Very truly yours,

CHEMDEX CORPORATION



David Perry
Chief Executive Officer


I have read and accept this employment offer:



    /s/ William C. Klintworth
- -----------------------------------
Signature of Employee.


Dated: 9/21/99

                                      -3-

<PAGE>

                                                                   EXHIBIT 10.25


                          CHANGE OF CONTROL AGREEMENT


     This Change of Control Agreement (the "Agreement") is made and entered into
effective as of September 21, 1999, by and between William Klintworth (the
"Employee") and Chemdex Corporation, a Delaware corporation (the "Company").


                                    RECITALS

     A.   It is expected that another company or other entity may from time to
time consider the possibility of acquiring the Company or that a change in
control may otherwise occur, with or without the approval of the Company's Board
of Directors (the "Board"). The Board recognizes that such consideration can be
a distraction to the Employee and can cause the Employee to consider alternative
employment opportunities. The Board has determined that it is in the best
interests of the Company and its stockholders to assure that the Company will
have the continued dedication and objectivity of the Employee, notwithstanding
the possibility, threat or occurrence of a Corporate Transaction (as defined
below) of the Company.

     B.   The Board believes that it is in the best interests of the Company and
its stockholders to provide the Employee with an incentive to continue his or
her employment with the Company.

     C.   The Board believes that it is imperative to provide the Employee with
certain benefits upon termination of the Employee's employment in connection
with a Corporate Transaction, which benefits are intended to provide the
Employee with financial security and provide sufficient encouragement to the
Employee to remain with the Company notwithstanding the possibility of a
Corporate Transaction.

     D.   To accomplish the foregoing objectives, the Board of Directors has
directed the Company, upon execution of this Agreement by the Employee, to agree
to the terms provided in this Agreement.

     E.   Certain capitalized terms used in the Agreement are defined in Section
3 below.

     In consideration of the mutual covenants herein contained, and in
consideration of the continuing employment of Employee by the Company, the
parties agree as follows:

          1.    At-Will Employment. The Company and the Employee acknowledge
that the Employee's employment is and shall continue to be at-will, as defined
under applicable law. If the Employee's employment terminates for any reason,
including (without limitation) any termination prior to a Corporate Transaction,
the Employee shall not be

                                       1
<PAGE>

entitled to any payments or benefits, other than as provided by this Agreement,
or as may otherwise be available in accordance with the terms of Employee's
offer letter from the Company (the "Offer Letter") and the Company's established
employee plans and written policies at the time of termination. The terms of
this Agreement shall terminate upon the earlier of (i) the date on which
Employee ceases for any reason to be employed by the Company prior to the
occurrence of a Corporate Transaction, (ii) the date that all obligations of the
parties hereunder have been satisfied, or (iii) one (1) year after the closing
of any Corporate Transaction. A termination of the terms of this Agreement
pursuant to the preceding sentence shall be effective for all purposes, except
that such termination shall not affect the payment or provision of compensation
or benefits on account of a termination of employment occurring prior to the
termination of the terms of this Agreement.

          2.    Stock Options and Restricted Stock. Subject to Sections 4 and 5
                ----------------------------------
below, in the event of a Corporate Transaction, if either Employee's employment
with the Company is terminated by the surviving entity without Cause or by
Employee as the result of a Constructive Termination by the surviving entity
within twelve months of the closing of the Corporate Transaction, each unvested
stock option granted for the Company's securities held by Employee and any
shares of the Company's Common Stock that are subject to a right of repurchase
by the Company pursuant to the terms of a Restricted Stock Purchase Agreement
("Restricted Stock") held by the Employee shall become vested on the effective
date of the termination or Constructive Termination as if Employee had been
employed by the surviving entity for an additional six months following such
termination. Each stock option shall otherwise vest in accordance with the
provisions of the Stock Option Agreement and the Company's 1998 Stock Option
Plan pursuant to which such option was granted and each Share of Restricted
Stock shall be freely transferable to the extent so vested in accordance with
the provisions of the Restricted Stock Purchase Agreement pursuant to which such
stock was purchased by Employee.

          3.    Definition of Terms. The following terms referred to in this
                -------------------
Agreement shall have the following meanings:

                (a) Corporate Transaction. "Corporate Transaction" shall mean
                    ---------------------
the occurrence of either of the following stockholder-approved events to which
the Company is a party:

                    (i)  a merger or consolidation in which securities
possessing more than fifty percent (50%) of the total combined voting power of
the Company's outstanding securities are transferred to a person or persons
different from the persons holding those securities immediately prior to such
transaction; or

                    (ii) the sale, transfer or other disposition of all or
substantially all of the Company's assets in complete liquidation or dissolution
of the Company.

                (b) Cause.  "Cause" shall mean:
                             -----

                                       2
<PAGE>

                    (i)   conviction of a felony or a crime involving
fraud or moral turpitude; or

                    (ii)  intentional or reckless conduct or gross negligence
materially harmful to the surviving entity after a Corporation Transaction,
including violation of a non-competition or confidentiality agreement.

Cause shall not include poor performance in the achievement of the Employee's
            ---
job objectives or the death or physical disability of the Employee.

              (c)   Constructive Termination. "Constructive Termination" shall
                    ------------------------
mean the Employee's voluntary termination, upon 30 days prior written notice to
the Company, following:

                    (i)   a material reduction or change in the Employee's job
duties, responsibilities and requirements inconsistent with the Employee's
position with the Company and the Employee's prior duties, responsibilities and
requirements;

                    (ii)  any reduction of greater than 5% in the Employee's
base compensation (including salary, benefits, incentive payments and bonuses),
other than in connection with a general decrease in base salaries for most
officers of the Company and any successor corporation; or

                    (iii) the Employee's refusal to relocate to a facility or
location more than 50 miles from the Company's current location.

          4.  Limitation on Payments. In the event that the benefits provided
              ----------------------
for in this Agreement to the Employee (i) constitute "parachute payments" within
the meaning of Section 280G of the Internal Revenue Code of 1986, as amended
(the "Code") and (ii) but for this Section, would be subject to the excise tax
imposed by Section 4999 of the Code, then the Employee's benefits under Section
2 shall be payable either:

              (a)  in full, or

              (b)  as to such lesser amount which would result in no portion of
such severance benefits being subject to excise tax under Section 4999 of the
Code,

whichever of the foregoing amounts, taking into account the applicable federal,
state and local income taxes and the excise tax imposed by Section 4999, results
in the receipt by the Employee on an after-tax basis, of the greatest amount of
benefits under Section 2 notwithstanding that all or some portion of such
severance benefits may be taxable under Section 4999 of the Code.  Unless the
Company and the Employee otherwise agree in writing, any determination required
under this Section 4 shall be made in writing by the Company's independent
public accountants (the "Accountants"), whose determination shall be conclusive
and binding upon the Employee and the Company for all purposes.  For

                                       3
<PAGE>

purposes of making the calculations required by this Section 4, the Accountants
may make reasonable assumptions and approximations concerning applicable taxes
and may rely on reasonable, good faith interpretations concerning the
application of Section 280G and 4999 of the Code. The Company and the Employee
shall furnish to the Accountants such information and documents as the
Accountants may reasonably request in order to make a determination under this
Section. The Company shall bear all costs the Accountants may reasonably incur
in connection with any calculations contemplated by this Section 4.

          5.   Certain Business Combinations. In the event it is determined by
               -----------------------------
the Board, upon consultation with Company management and the Company's
independent auditors, that the enforcement of any Section of this Agreement,
including, but not limited to, Section 2 hereof, which allows for the
acceleration of vesting of stock options and Restricted Stock granted for the
Company's securities upon the effective date of a Corporate Transaction would
preclude accounting for any proposed business combination of the Company
involving a Corporate Transaction as a pooling of interests, and the Board
otherwise desires to approve such a proposed business transaction which requires
as a condition to the closing of such transaction that it be accounted for as a
pooling of interests, then any such Section of this Agreement shall be null and
void. For purposes of this Section 5, the Board's determination shall require
the unanimous approval of the non-employee Board members.

          6.   Successors. Any successor to the Company (whether direct or
               ----------
indirect and whether by purchase, lease, merger, consolidation, liquidation or
otherwise) to all or substantially all of the Company's business and/or assets
shall assume the obligations under this Agreement and agree expressly to perform
the obligations under this Agreement in the same manner and to the same extent
as the Company would be required to perform such obligations in the absence of a
succession. The terms of this Agreement and all of the Employee's rights
hereunder shall inure to the benefit of, and be enforceable by, the Employee's
personal or legal representatives, executors, administrators, successors, heirs,
distributees, devisees and legatees.

          7.   Notice. Notices and all other communications contemplated by this
               ------
Agreement shall be in writing and shall be deemed to have been duly given when
personally delivered or when mailed by U.S. registered or certified mail, return
receipt requested and postage prepaid. Mailed notices to the Employee shall be
addressed to the Employee at the home address which the Employee most recently
communicated to the Company in writing. In the case of the Company, mailed
notices shall be addressed to its corporate headquarters, and all notices shall
be directed to the attention of its Secretary.

          8.   Miscellaneous Provisions.
               ------------------------

               (a) No Duty to Mitigate.  The Employee shall not be required to
                   -------------------
mitigate the amount of any benefit contemplated by this Agreement (whether by
seeking new employment or in any other manner), nor, except as otherwise
provided in this Agreement,

                                       4
<PAGE>

shall any such benefit be reduced by any earnings that the Employee may receive
from any other source.

             (b)  Waiver. No provision of this Agreement shall be modified,
                  ------
waived or discharged unless the modification, waiver or discharge is agreed to
in writing and signed by the Employee and by an authorized officer of the
Company (other than the Employee). No waiver by either party of any breach of,
or of compliance with, any condition or provision of this Agreement by the other
party shall be considered a waiver of any other condition or provision or of the
same condition or provision at another time.

             (c)  Whole Agreement. No agreements, representations or
                  ---------------
understandings (whether oral or written and whether express or implied) which
are not expressly set forth in this Agreement have been made or entered into by
either party with respect to the subject matter hereof. This Agreement
supersedes any agreement of the same title and concerning similar subject matter
dated prior to the date of this Agreement, and by execution of this Agreement
both parties agree that any such predecessor agreement shall be deemed null and
void.

             (d) Choice of Law.  The validity, interpretation, construction and
                 -------------
performance of this Agreement shall be governed by the laws of the State of
California without reference to conflict of laws provisions.

             (e) Severability. If any term or provision of this Agreement or
                 ------------
the application thereof to any circumstance shall, in any jurisdiction and to
any extent, be invalid or unenforceable, such term or provision shall be
ineffective as to such jurisdiction to the extent of such invalidity or
unenforceability without invalidating or rendering unenforceable the remaining
terms and provisions of this Agreement or the application of such terms and
provisions to circumstances other than those as to which it is held invalid or
unenforceable, and a suitable and equitable term or provision shall be
substituted therefor to carry out, insofar as may be valid and enforceable, the
intent and purpose of the invalid or unenforceable term or provision.

             (f) Arbitration.  Any dispute or controversy arising under or in
                 -----------
connection with this Agreement may be settled at the option of either party by
binding arbitration in the County of San Mateo, California, in accordance with
the rules of the American Arbitration Association then in effect.  Judgment may
be entered on the arbitrator's  award in any court having jurisdiction.
Punitive damages shall not be awarded.

             (g) Legal Fees and Expenses. The parties shall each bear their own
                 -----------------------
expenses, legal fees and other fees incurred in connection with this Agreement.

             (h) No Assignment of Benefits. The rights of any person to
                 -------------------------
payments or benefits under this Agreement shall not be made subject to option or
assignment, either by voluntary or involuntary assignment or by operation of
law, including (without

                                       5
<PAGE>

limitation) bankruptcy, garnishment, attachment or other creditor's process, and
any action in violation of this subsection (h) shall be void.

              (i) Employment Taxes. Any payments made pursuant to this Agreement
                  ----------------
will be subject to withholding of applicable income and employment taxes.

              (j) Assignment by Company. The Company may assign its rights under
                  ---------------------
this Agreement to an affiliate, and an affiliate may assign its rights under
this Agreement to another affiliate of the Company or to the Company; provided,
however, that no assignment shall be made if the net worth of the assignee is
less than the net worth of the Company at the time of assignment. In the case of
any such assignment, the term "Company" when used in a section of this Agreement
shall mean the corporation that actually employs the Employee.

              (k) Counterparts.  This Agreement may be executed in counterparts,
                  ------------
each of which shall be deemed an original, but all of which together will
constitute one and the same instrument.


                           [Signature Page Follows]

                                       6
<PAGE>

     IN WITNESS WHEREOF, each of the parties has executed this Agreement, in the
case of the Company by its duly authorized officer, as of the day and year first
above written.


CHEMDEX CORPORATION                                WILLIAM KLINTWORTH


By: /s/ David P. Perry                          /s/ William Klintworth
    ------------------                          ----------------------

Title:      CEO
      ---------------

                                       7

<PAGE>
                                                                   EXHIBIT 10.26
                          COMPANY AFFILIATE AGREEMENT


     THIS AFFILIATE AGREEMENT is entered into as of  September 21, 1999 (this
"Agreement"), by and among Chemdex Corporation, a Delaware corporation
("Parent"), Promedix.com, Inc., a Delaware corporation (the "Company"), and
_______________________ ("Affiliate").

                                    RECITALS
                                    --------

     A.   Parent, Popcorn Acquisitions Corp., a Delaware corporation and wholly
owned subsidiary of Parent ("Merger Sub"), and the Company have entered into an
Agreement and Plan of Merger dated as of September __, 1999 (the "Merger
Agreement"), providing for the merger of Merger Sub with and into the Company
(the "Merger"). The Merger Agreement contemplates that, upon consummation of the
Merger, (i) the holders of the capital stock of the Company ("Company Capital
Stock") will receive shares of common stock of Parent ("Parent Common Stock") in
exchange for their shares of Company Capital Stock, and (ii) the Company will
become a wholly-owned subsidiary of Parent. It is accordingly contemplated that
Affiliate will receive shares of Parent Common Stock in the Merger.

     B.   Affiliate understands that the Parent Common Stock being issued in the
Merger will be issued pursuant to a registration statement on Form S-4 and that
Affiliate may be deemed to be an "affiliate" of the Company, as the term
"affiliate" is used for purposes of paragraphs (c) and (d) of Rule 145 ("Rule
145") of the General Rules and Regulations of the Securities and Exchange
Commission (the "SEC") under the Securities Act of 1933, as amended (the
"Securities Act"), and as such, Affiliate may only transfer, sell or dispose of
such Parent Common Stock in accordance with this Affiliate Agreement and Rule
145.

     NOW, THEREFORE, in order to induce Parent to consummate the transactions
contemplated by the Merger Agreement, and for other valuable consideration (the
receipt and sufficiency of which are hereby acknowledged by Affiliate),
Affiliate hereby covenants and agrees as follows:

                                   ARTICLE I

     1.   Representations and Warranties of Affiliate.  Affiliate represents and
          -------------------------------------------
warrants to Parent as follows:

          1.1  Ownership.  Affiliate is the holder and "beneficial owner" (as
               ---------
defined in Rule 13d-3 under the Securities Exchange Act of 1934, as amended) of
the number of shares of the Company Capital Stock set forth under Affiliate's
signature below (the "Company Shares"), and Affiliate has good and valid title
to the Company Shares, free and clear of any liens, pledges, security interests,
adverse claims, equities, options, proxies, charges, encumbrances or
restrictions of any nature.

                                      -1-
<PAGE>

          1.2  Limitation on Transfer.  Affiliate has carefully read this
               ----------------------
Agreement, and has discussed with Affiliate's own independent counsel to the
extent Affiliate felt necessary the limitations imposed on Affiliate's ability
to sell, transfer or otherwise dispose of the shares of Parent Common Stock that
Affiliate is to receive in the Merger (the "Parent Shares").  Affiliate fully
understands the limitations this Agreement places upon Affiliate's ability to
sell, transfer or otherwise dispose of the Parent Shares and the Company Shares.

                                  ARTICLE II

     2.   Transfer Restrictions.
          ---------------------

          2.1  Prohibition Against Transfer.  In addition to the restrictions
               ----------------------------
set forth elsewhere herein, Affiliate agrees that Affiliate shall not effect any
sale, transfer or other disposition of the Parent Shares unless:

               (a)  such sale, transfer or other disposition is made in
conformity with the volume and other requirements of Rule 145 under the
Securities Act;

               (b)  such sale, transfer or other disposition is effected
pursuant to an effective registration statement under the Securities Act; or

               (c)  an authorized representative of the SEC shall have rendered
written advice to Affiliate to the effect that the SEC would take no action, or
that the staff of the SEC would not recommend that the SEC take action, with
respect to such proposed sale, transfer or other disposition, and a copy of such
written advice and all other related communications with the SEC shall have been
delivered to Parent.

          2.2  Stop Transfer Instructions; Legend. Affiliate acknowledges and
               ----------------------------------
agrees that (a) stop transfer instructions will be given to Parent's transfer
agent with respect to the Parent Shares, and (b) each certificate representing
any of such shares of Parent Common Stock or any substitutions thereof shall
bear a legend (together with any other legend or legends required by applicable
state securities laws or otherwise), stating in substance:

     THE SHARES REPRESENTED BY THIS CERTIFICATE WERE ISSUED IN A
     TRANSACTION TO WHICH RULE 145 PROMULGATED UNDER THE SECURITIES
     ACT OF 1933 APPLIES. THE SHARES REPRESENTED BY THIS CERTIFICATE
     MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, ASSIGNED,
     PLEDGED OR HYPOTHECATED EXCEPT IN ACCORDANCE WITH THE PROVISIONS
     OF SUCH RULE AND IN ACCORDANCE WITH THE TERMS OF AN AGREEMENT
     DATED AS OF SEPTEMBER __, 1999 BETWEEN THE REGISTERED HOLDER
     HEREOF AND CHEMDEX CORPORATION, A COPY OF WHICH AGREEMENT IS ON
     FILE AT THE PRINCIPAL OFFICES OF CHEMDEX CORPORATION.

                                  ARTICLE III

                                      -2-
<PAGE>

     3.   General Provisions.
          ------------------

          3.1  Specific Performance.  The parties agree that irreparable damage
               --------------------
would occur in the event that any of the provisions of this Agreement were not
performed in accordance with its specific terms or were otherwise breached.
Affiliate agrees that, in the event of any breach or threatened breach by
Affiliate of any covenant or obligation contained in this Agreement, each of
Parent and the Company shall be entitled (in addition to any other remedy that
may be available to it, including monetary damages) to seek and obtain (a) a
decree or order of specific performance to enforce the observance and
performance of such covenant or obligation, and (b) an injunction restraining
such breach or threatened breach.

          3.2  Independence of Obligations.  The covenants and obligations
               ---------------------------
of Affiliate set forth in this Affiliate Agreement shall be construed as
independent of any other agreement or arrangement between Affiliate, on the one
hand, and the Company or Parent, on the other. The existence of any claim or
cause of action by Affiliate against the Company or Parent shall not constitute
a defense to the enforcement of any of such covenants or obligations against
Affiliate.

          3.3  Notices. Any notice or other communication required or permitted
               -------
to be delivered under this Agreement shall be in writing and shall be deemed
properly delivered, given and received when delivered (by hand, by registered
mail, by courier or express delivery service or by facsimile confirmation) to
the address or facsimile telephone number set forth beneath the name of such
party below (or to such other address or facsimile telephone number as such
party shall have specified in a written notice given to the other party):

     If to Parent:            Chemdex Corporation
                              3950 Fabian Way
                              Palo Alto, CA 94308
                              Attention: Chief Executive Officer
                              Telephone No.: (650) 813-0300
                              Telecopy No.:  (650) 813-0304

     with a copy at the same address to the attention of the General Counsel and
     Secretary and with a copy to:

                              Venture Law Group
                              A Professional Corporation
                              2800 Sand Hill Road
                              Menlo Park, California 94025
                              Attention: Steven J. Tonsfeldt
                              Telephone No.: (650) 854-4488
                              Telecopy No.:  (650) 233-8386

                                      -3-
<PAGE>

     If to Company:           Promedix.com, Inc.
     448 East Winchester      Avenue, Suite 200
                              Salt Lake City, Utah 84107
                              Attention: Chief Executive Officer
                              Telephone No.: (800) 453-1264
                              Telecopy No.:  (801) 261-7475

     With  a copy to:         Orrick, Herrington & Sutcliffe LLP
                              1020 Marsh Road
                              Menlo Park, CA 94025
                              Attention:  Geoffrey P. Leonard, Esq.
                              Telephone No.: (650) 614-7470
                              Telecopy No.:  (650) 614-7401

     If to Affiliate:

     at the address or facsimile phone number set forth below Affiliate's
     signature on the signature page hereof.

     With a copy to:          _____________________________
                              _____________________________
                              _____________________________
                              Attention:  _________________
                              Telephone No.:  _____________
                              Telecopy No.:  ______________

          3.4  Severability.  If any provision of this Agreement or any part of
               ------------
any such provision is held under any circumstances to be invalid or
unenforceable in any jurisdiction, then (a) such provision or part thereof
shall, with respect to such circumstances and in such jurisdiction, be deemed
amended to conform to applicable laws so as to be valid and enforceable to the
fullest possible extent, (b) the invalidity or unenforceability of such
provision or part thereof under such circumstances and in such jurisdiction
shall not affect the validity or enforceability of such provision or part
thereof under any other circumstances or in any other jurisdiction, and (c) the
invalidity or unenforceability of such provision or part thereof shall not
affect the validity or enforceability of the remainder of such provision or the
validity or enforceability of any other provision of this Agreement. Each
provision of this Agreement is separable from every other provision of this
Agreement, and each part of each provision of this Agreement is separable from
every other part of such provision.

          3.5  Governing Law.  This Agreement shall be construed in accordance
               -------------
with, and governed in all respects by, the laws of the State of Delaware
(without giving effect to principles of conflicts of laws).

          3.6  Waiver.  No failure on the part of Parent or the Company to
               ------
exercise any power, right, privilege or remedy under this Agreement, and no
delay on the part of Parent or the Company in exercising any power, right,
privilege or remedy under this Agreement, shall operate as a waiver of such
power, right, privilege or remedy; and no single or partial exercise of any

                                      -4-
<PAGE>

such power, right, privilege or remedy shall preclude any other or further
exercise thereof or of any other power, right, privilege or remedy. Neither
Parent or the Company shall be deemed to have waived any claim arising out of
this Agreement, or any power, right, privilege or remedy under this Agreement,
unless the waiver of such claim, power, right, privilege or remedy is expressly
set forth in a written instrument duly executed and delivered on behalf of the
party deemed to be charged; and any such waiver shall not be applicable or have
any effect except in the specific instance in which it is given.

          3.7   Captions.  The captions contained in this Agreement are for
                --------
convenience of reference only, shall not be deemed to be a part of this
Agreement and shall not be referred to in connection with the construction or
interpretation of this Agreement.

          3.8   Further Assurances.  Affiliate shall execute and/or cause to be
                ------------------
delivered to Parent or the Company such instruments and other documents and
shall take such other actions as Parent or the Company may reasonably request to
effectuate the intent and purposes of this Agreement.

          3.9   Entire Agreement.  This Agreement, the Merger Agreement and any
                ---------------
Voting Agreement (including any irrevocable proxy contained therein) between
Affiliate and Parent constitute the entire agreement between the parties with
respect to the subject matter hereof and thereof and supersede all prior
agreements and understandings between the parties with respect thereto.

          3.10  Non-Exclusivity.  The rights and remedies of Parent and the
                ---------------
Company hereunder are not exclusive of or limited by any other rights or
remedies which Parent may have, whether at law, in equity, by contract or
otherwise, all of which shall be cumulative (and not alternative). Nothing in
this Agreement shall limit any of Affiliate's obligations, or the rights or
remedies of Parent or the Company, under any Voting Agreement (including any
irrevocable proxy contained therein) between Parent and Affiliate (to the extent
that Affiliate shall have entered into such an agreement), and nothing in any
such Voting Agreement (including any irrevocable proxy contained therein) shall
limit any of Affiliate's obligations, or any of the rights or remedies of
Parent, under this Agreement.

          3.11  Amendments.  This Agreement may not be amended, modified,
                ----------
altered, or supplemented other than by means of a written instrument duly
executed and delivered on behalf of Parent, the Company and Affiliate.

          3.12  Binding Nature.  This Agreement will be binding upon Affiliate
                --------------
and Affiliate's representatives, executors, administrators, estate, heirs,
successors and assigns, and shall inure to the benefit of the Company, Parent
and their respective successors and assigns.

          3.13  Attorney's Fees and Expenses.  If any legal action or other
                ----------------------------
legal proceeding relating to the enforcement of any provision of this Agreement
is brought against Affiliate, the prevailing party shall be entitled to recover
reasonable attorneys' fees, costs and disbursements (in addition to any other
relief to which the prevailing party may be entitled).

          3.14  Assignment.  This Agreement and all obligations of Affiliate
                ----------
hereunder are personal to Affiliate and may not be transferred or delegated by
Affiliate at any time.  The

                                      -5-
<PAGE>

Company or Parent may freely assign any or all of its rights under this
Affiliate Agreement, in whole or in part to any other person or entity without
obtaining the consent or approval of Affiliate.

          3.15  Survival. Each of the representations, warranties, covenants
                --------
and obligations contained in this Agreement shall survive the consummation of
the Merger.

                           [Signature Page Follows]

                                      -6-
<PAGE>

          IN WITNESS WHEREOF, the undersigned have executed this Company
Affiliate Agreement as of the date first set forth above.

                                    CHEMDEX CORPORATION



                                    By: /s/ David Perry
                                        -----------------------------

                                    Title:___________________________



                                    PROMEDIX.COM, INC.



                                    By: /s/ William C. Klintwort
                                        -----------------------------

                                    Title:___________________________



                                    AFFILIATE: /s/ Ed Kuklenski
                                               ----------------------

                                    Address:_________________________

                                    _________________________________

                                    _________________________________

                                    Facsimile:_______________________


                                    COMPANY STOCK BENEFICIALLY OWNED
                                    BY AFFILIATE:

                                    _______________ shares of Common Stock
                                    _______________ shares of Common Stock
                                    issuable upon exercise of outstanding
                                    options


                      ****COMPANY AFFILIATE AGREEMENT****

                                      -7-
<PAGE>

IN WITNESS WHEREOF, the undersigned have executed this Company Affiliate
Agreement as of the date first set forth above.

                                    CHEMDEX CORPORATION



                                    By:______________________________

                                    Title:___________________________



                                    PROMEDIX.COM, INC.



                                    By:______________________________

                                    Title:___________________________



                                    AFFILIATE:  /s/ John Benear
                                                ---------------------

                                    Address:_________________________

                                    _________________________________

                                    _________________________________

                                    Facsimile:_______________________


                                    COMPANY STOCK BENEFICIALLY OWNED
                                    BY AFFILIATE:

                                    _______________ shares of Common Stock
                                    _______________ shares of Common Stock
                                    issuable upon exercise of outstanding
                                    options


                      ****COMPANY AFFILIATE AGREEMENT****

IN WITNESS WHEREOF, the undersigned have executed this Company Affiliate
Agreement as of the date first set forth above.

                                      -8-
<PAGE>

                                    CHEMDEX CORPORATION



                                    By:__________________________________

                                    Title:_______________________________



                                    PROMEDIX.COM, INC.



                                    By:__________________________________

                                    Title:_______________________________



                                    AFFILIATE:  /s/ Peter Mills @Ventures III,
                                             ---------------------------------
                                    L.P
                                    ---

                                    Address:_____________________________

                                    _____________________________________

                                    _____________________________________

                                    Facsimile:___________________________


                                    COMPANY STOCK BENEFICIALLY OWNED
                                    BY AFFILIATE:

                                    _______________ shares of Common Stock
                                    _______________ shares of Common Stock
                                    issuable upon exercise of outstanding
                                    options


                      ****COMPANY AFFILIATE AGREEMENT****

IN WITNESS WHEREOF, the undersigned have executed this Company Affiliate
Agreement as of the date first set forth above.

                                      -9-
<PAGE>

                                    CHEMDEX CORPORATION



                                    By: _____________________________

                                    Title: __________________________



                                    PROMEDIX.COM, INC.



                                    By: _____________________________

                                    Title: __________________________




                                    AFFILIATE: /s/ Barrie Brewer
                                             ------------------------

                                    Address:_________________________

                                    _________________________________

                                    _________________________________

                                    Facsimile:_______________________


                                    COMPANY STOCK BENEFICIALLY OWNED
                                    BY AFFILIATE:

                                    _______________ shares of Common Stock
                                    _______________ shares of Common Stock
                                    issuable upon exercise of outstanding
                                    options


                      ****COMPANY AFFILIATE AGREEMENT****

                                      -10-

<PAGE>

                                                                   EXHIBIT 10.28


                           NONCOMPETITION AGREEMENT


     THIS NONCOMPETITION AGREEMENT (this "Agreement") is entered into as of
September 21, 1999, by and between Chemdex Corporation., a Delaware corporation
("Chemdex") and William Klintworth ("Individual"), an employee of Promedix.com,
Inc. ("Promedix.com").

                                   RECITALS

     A.   Promedix.com is engaged in the business of operating an online
exchange for buyers and suppliers of specialty medical products.

     B.   Individual is a stockholder and an employee of Promedix.com and has
confidential and proprietary information relating to the business and operation
of Promedix.com.

     C.   Individual's covenant not to compete with Chemdex, as reflected in
this Agreement, is an essential part of the transactions described in that
certain Agreement and Plan of Merger dated as of September 21, 1999 (the "Merger
Agreement"), among Chemdex, Popcorn Acquisition Corp., a Delaware corporation
and a wholly owned subsidiary of Chemdex ("Sub"), and Promedix.com, whereby Sub
will be merged with and into Promedix.com (the transactions contemplated by the
Merger Agreement are referred to hereinafter as the "Merger").

     D.   As a condition to its willingness to enter into the Merger Agreement,
Chemdex has required that Individual agree, and Individual has agreed, to the
noncompetition and nonsolicitation covenants and the confidentiality agreements
provided in this Agreement.

     E.   References to Chemdex hereinafter shall include all subsidiaries of
Chemdex and shall include Promedix.com which is the surviving corporation in the
Merger.

                                   AGREEMENT

     NOW, THEREFORE, in consideration of the foregoing and to induce Chemdex to
consummate the transactions contemplated by the Merger Agreement, and for other
good and valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, Individual hereby covenants and agrees as follows:


     1.   Noncompetition.
          --------------

          (a) Individual and Chemdex agree that due to the nature of
Individual's employment with Promedix.com, Individual has confidential and
proprietary information relating to the business and operations of Promedix.com.
Individual acknowledges that such information is of importance to the "Business"
(as defined below) and will continue to be so after the Merger and that
disclosure of such confidential information to others or the unauthorized use of
such

                                       1
<PAGE>

information by others would cause substantial loss and harm to Promedix.com and,
following the Merger, Chemdex.

          (b) During the period which shall commence at the Effective Time and
shall terminate on the first anniversary of the termination of Individual's
employment with the Company (such period, the "Restricted Period"), Individual
shall not directly or indirectly (including without limitation, through any
Affiliate (as defined below) of Individual), own, manage, operate, control or
otherwise engage or participate in, or be connected as an owner, partner,
principal, creditor, salesman, guarantor, advisor, member of the board of
directors of, employee of or consultant in any entity or business where such
entity or business (i) devotes 20% or more of its resources to a division,
group, or other subset of such entity or business, that is engaging in or is
developing a business competitive with the Business or (ii) generates 20% or
more of its gross revenues or earnings from a business competitive with the
Business.

          (c) Notwithstanding the foregoing provisions of Section 1(b) and the
restrictions set forth therein, Individual may own securities in any publicly
held corporation that is covered by the restrictions set forth in Section 1(b),
but only to the extent that Individual does not own, of record or beneficially,
more than 1% of the outstanding beneficial ownership of such corporation.

          (d) The restrictions set forth in Section 1(b) shall apply to the
United States (the "Business Area").

          (e) "Affiliate" as used herein, means, with respect to any person or
entity, any person or entity directly or indirectly controlling, controlled by
or under direct or indirect common control with such other person or entity.

          (f) "Business" as used herein means the operation of a business
primarily engaged in health care e-commerce.

     2.   Nonsolicitation of Chemdex Employees. During the Restricted Period,
          ------------------------------------
Individual shall not, without the prior written consent of Chemdex, directly or
indirectly (including without limitation, through any Affiliate of Individual),
solicit, request, cause or induce any person who is at the time, or 12 months
prior thereto had been, an employee of or a consultant of Chemdex to leave the
employ of or terminate such person's relationship with Chemdex.

     3.   Nonsolicitation of Customers. During the Restricted Period, Individual
          ----------------------------
shall not, directly or indirectly (including without limitation, through any
Affiliate of Individual) (i) solicit, induce or attempt to induce any customer
of Chemdex, including but not limited to any customer of Promedix.com that was a
customer of Chemdex or Promedix.com while the Individual was an employee of
Chemdex or Promedix.com, as the case may be, or during the Restricted Period, to
cease doing business in whole or in part with Chemdex with respect to the
Business; (ii) attempt to limit or interfere with any business agreement or
relationship existing between Chemdex and/or its Affiliates with any third
party; or (iii) make materially false statements, or take intentional actions,
which are intended to disparage the business reputation of Chemdex (or its
management team) or take any intentional actions which are intended to result in
material harm

                                       2
<PAGE>

to Chemdex's goodwill with its customers, content providers, bandwidth or other
network infrastructure providers, vendors, employees, the media or the public.

     4.   Confidentiality.  Prior to the Effective Time, Individual will execute
          ---------------
Chemdex's standard employee proprietary information and invention assignment
agreement.

     5.   Stay of Time.  In the event that either party shall request a court of
          ------------
competent jurisdiction (collectively a "Court") or other entity or person
mutually selected by the parties to determine whether the Individual has
violated the provisions of this Agreement, the running of the time period of
such provisions so violated shall be automatically suspended as of the date of
such violation and shall resume on the date of the final order or remedy that
the Court or other entity or person rules or determines that such violation
occurred.

     6.   Injunctive Relief.  The remedy at law for any breach of this Agreement
          -----------------
is and will be inadequate, and in the event of a breach or threatened breach by
Individual of the provisions of Sections 1, 2 or 3 of this Agreement,
Promedix.com and Chemdex shall be entitled to seek an injunction restraining
Individual from the conduct which would constitute a breach of this Agreement.
Nothing herein contained shall be construed as prohibiting Promedix.com or
Chemdex from pursuing any other remedies available to it or them for such breach
or threatened breach, including, without limitation, the recovery of damages
from Individual.

     7.   Separate Covenants.  This Agreement shall be deemed to consist of a
          ------------------
series of separate covenants, one for each line of business carried on by the
Business and each county, state, country or other region included within the
Business Area.  The parties expressly agree that the character, duration and
geographical scope of this Agreement are reasonable in light of the
circumstances as they exist on the date upon which this Agreement has been
executed.  However, should a determination nonetheless be made by a court of
competent jurisdiction at a later date that the character, duration or
geographical scope of this Agreement is unreasonable in light of the
circumstances as they then exist, then it is the intention and the agreement of
Individual that this Agreement shall be construed by the court in such a manner
as to impose only those restrictions on the conduct of Individual that are
reasonable in light of the circumstances as they then exist and as are necessary
to assure Promedix.com. and Chemdex of the intended benefit of this Agreement.
If, in any judicial proceeding, a court shall refuse to enforce all of the
separate covenants deemed included herein because, taken together, they are more
extensive than necessary to assure Chemdex of the intended benefit of this
Agreement, it is expressly understood and agreed among the parties hereto that
those of such covenants that, if eliminated, would permit the remaining separate
covenants to be enforced in such proceeding shall, for the purpose of such
proceeding, be deemed eliminated from the provisions hereof.

     8.   Severability.  If any of the provisions of this Agreement shall
          ------------
otherwise contravene or be invalid under the laws of any state, country or other
jurisdiction where this Agreement is applicable but for such contravention or
invalidity, such contravention or invalidity shall not invalidate all of the
provisions of this Agreement but rather it shall be construed, insofar as the
laws of that state, country or jurisdiction are concerned, as not containing the
provision or

                                       3
<PAGE>

provisions contravening or invalid under the laws of that state or jurisdiction,
and the rights and obligations created hereby shall be construed and enforced
accordingly.

     9.   Construction.  This Agreement shall be construed and enforced in
          ------------
accordance with and governed by the laws of the State of Utah, without regard to
principles of conflicts or choice of laws; provided, however, that with respect
to activities occurring in a particular jurisdiction, the law of such
jurisdiction shall apply solely to the extent it results in the greatest
enforcement of the terms of this Agreement.

     10.  Amendments and Waivers.  This Agreement may be modified only by a
          ----------------------
written instrument duly executed by each party hereto.  No breach of any
covenant, agreement, warranty or representation shall be deemed waived unless
expressly waived in writing by the party who might assert such breach.  No
waiver of any right hereunder shall operate as a waiver of any other right or of
the same or a similar right on another occasion.

     11.  Entire Agreement.  This Agreement, together with the Merger Agreement,
          ----------------
the offer letter to which this is attached and Chemdex's employee
confidentiality and investors agreement, and the ancillary documents executed in
connection therewith, contains the entire understanding of the parties relating
to the subject matter hereof, supersedes all prior and contemporaneous
agreements and understandings relating to the subject matter hereof and shall
not be amended except by a written instrument signed by each of the parties
hereto.

     12.  Counterparts.  This Agreement may be executed by the parties in
          ------------
separate counterparts, each of which, when so executed and delivered, shall be
an original, but all of which, when taken as a whole, shall constitute one and
the same instrument.

     13.  Section Headings.  The headings of each Section, subsection or other
          ----------------
subdivision of this Agreement are for reference only and shall not limit or
control the meaning thereof.

     14.  Assignment.  Neither this Agreement nor any right, remedy, obligation
          ----------
or liability arising hereunder or by reason hereof nor any of the documents
executed in connection herewith may be assigned by any party without the consent
of the other parties; provided, however, that Chemdex and Promedix.com may
assign their rights hereunder, without the consent of Individual, to any entity
that acquires or succeeds to the Business.

     15.  Further Assurances.  From time to time, at Chemdex's request and
          ------------------
without further consideration, Individual shall execute and deliver such
additional documents and take all such further action as reasonably requested by
Promedix.com or Chemdex to be necessary or desirable to make effective, in the
most expeditious manner possible, the terms of this Agreement.

     16.  Notices.  All notices and other communications hereunder shall be in
          -------
writing and shall be deemed given if delivered personally or two business days
after being mailed by registered or certified mail (return receipt requested) to
the parties at the following addresses (or at such other address for a party as
shall be specified by like notice):

                                       4
<PAGE>

          (a)  if to Chemdex:

               Chemdex Corporation
               3950 Fabian Way
               Palo Alto, CA  94303
               Attention:  Chief Executive Officer

               with a copy to:

               Venture Law Group
               A Professional Corporation
               2775 Sand Hill Road
               Menlo Park, CA  94025
               Attention: Jeffrey Y. Suto

          (b)  if to Individual:

               to the address set forth below the name of Individual on the
               signature page hereof.

     17.  Effectiveness.  Notwithstanding any other provision of this Agreement,
          -------------
this Agreement shall become effective only upon the Effective Time, and if such
Effective Time shall not occur prior to the termination of the Merger Agreement
this Agreement shall be deemed void ab initio and have no further force or
effect upon such termination of the Merger Agreement.

     19.  Defined Terms.  Capitalized terms not otherwise defined herein shall
          -------------
have the meanings given to them in the Merger Agreement.

                                    ********

                                       5
<PAGE>

     IN WITNESS WHEREOF, the parties hereto have executed this Noncompetition
Agreement as of the date first above written.

                                  CHEMDEX CORPORATION


                                  By:_______________________________

                                  Name:_____________________________

                                  Title:____________________________



                                  INDIVIDUAL:



                                  /s/ William Klintworth
                                  ______________________
                                  Address  c/o Promedix, Inc.
                                           448 East Winchester Avenue, Suite 200
                                           Salt Lake City, UT

                                       6

<PAGE>

                                                                  Exhibit 21.1


                     Subsidiaries of Chemdex Corporation

<TABLE>
<CAPTION>

                                        State of
        Name                          Incorporation
        ----                          -------------
<S>                             <C>
Popcorn Acquisitions Corp.              Delaware
</TABLE>

<PAGE>

                                                                    Exhibit 23.4


              CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

        We consent to the reference to our firm under the caption "Experts" and
to the use of our report dated May 7, 1999 (except for Note 9, as to which the
date is July 23, 1999) in the Proxy Statement and Prospectus included in the
Registration Statement (Form S-4) of Chemdex Corporation for the registration of
12,057,366 shares of its common stock.

        Our audits also included the financial statement schedule of Chemdex
Corporation included in the Registration Statement. This schedule is the
responsibility of the Company's management. Our responsibility is to express an
opinion based on our audits. In our opinion, the financial statement schedule
referred to above, when considered in relation to the basic financial statements
taken as a whole, presents fairly in all material respects the information set
forth therein.


                             /s/ Ernst & Young LLP

San Jose, California
November 10, 1999









<PAGE>

                                                                    Exhibit 23.5


              CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

        We consent to the reference to our firm under the caption "Experts" and
to the use of our report dated October 15, 1999 on the financial statements of
Promedix.com Inc. in the Proxy Statement and Prospectus included in the
registration Statement (Form S-4) of Chemdex Corporation for the registration
of 12,057,366 shares of its common stock.

        Our audits also included the financial statement schedule of
Promedix.com, Inc. included in the Registration Statement. This schedule is the
responsibility of the Company's management. Our responsibility is to express an
opinion based on our audits. In our opinion, the financial statement schedule
referred to above, when considered in relation to the basic financial statements
taken as a whole, presents fairly in all material respects the information set
forth therein.


                             /s/ Ernst & Young LLP

Salt Lake City, Utah
November 10, 1999








<PAGE>

                                                                    EXHIBIT 23.6



             CONSENT OF INDEPENDENT CERTIFIED PUBLIC ACCOUNTANTS
             ---------------------------------------------------


U.S. Securities and Exchange Commission
450 5th Street, N.W.
Washington, D.C. 20549


Re:  Consent to be named in the S-4 Registration Statement of
     Chemdex Corporation, a Delaware corporation (the "Registrant")

Ladies and Gentlemen:

We hereby consent to the use of our report prepared for Pro Med Co., Inc. (dba
Promedix), a subsidiary of the Registrant for the years ended December 31,
1998 and 1997, dated January 28, 1999, in the above referenced Registration
Statement. We also consent to the use of our name as experts in such
Registration Statement.

Yours very sincerely,

/s/ Jones, Jensen & Company

Jones, Jensen & Company
Salt Lake City, Utah
November 8, 1999

<PAGE>

                                                                    Exhibit 23.7




                                                               November 10, 1999


Chemdex Corporation
3950 Fabian Way
Palo Alto, CA 94303

Dear Sirs:

     We hereby consent to the use of our name and to the description of our
opinion letter, dated August 31, 1999, in, and to the inclusion of such opinion
letter as Annex C to, the Proxy Statement/Prospectus of Chemdex Corporation,
constituting part of the Registration Statement on Form S-4 of Chemdex
Corporation, filed with the Securities and Exchange Commission.  In giving such
consent, we do not thereby admit that we come within the category of persons
whose consent is required under, or that we are experts with respect to any part
of such Registration Statement within the meaning of the term "experts" as used
in, the Securities Act of 1933, as amended, or the rules and regulations of the
Securities and Exchange Commission promulgated thereunder.

                         Very truly yours,


                         MORGAN STANLEY & CO. INCORPORATED



                         By:  /s/ Geoffrey D. Baldwin
                              ----------------------------
                              Geoffrey D. Baldwin
                              Principal


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