BIOMARIN PHARMACEUTICAL INC
S-3/A, EX-10, 2001-01-11
PHARMACEUTICAL PREPARATIONS
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                                                                    Exhibit 10.1

                              EMPLOYMENT AGREEMENT

     This EMPLOYMENT  AGREEMENT (the  "Agreement"),  made as of October 31, 2000
(the "Effective Date") by and between BioMarin  Pharmaceutical  Inc., a Delaware
corporation with its principal  executive  offices located at 371 Bel Marin Keys
Boulevard,  Suite 210,  Novato,  California 94949 (the "Company") and FREDRIC D.
PRICE, residing at 64 Quarry Lane, Bedford, New York 10506 (the "Executive").

                              W I T N E S S E T H :

     WHEREAS,  the Company is a developer of carbohydrate  enzyme  therapies for
the treatment of debilitating,  life-threatening,  chronic genetic disorders and
other diseases and conditions (the "Business"); and

     WHEREAS,  the Company recognizes that Executive possesses unique skills and
abilities which are essential to the Company's Business,  the Company desires to
employ Executive and Executive desires to be so employed by the Company.

     NOW THEREFORE,  in consideration of the foregoing  premises,  and for other
good and valuable consideration, the receipt and sufficiency of which are hereby
acknowledged,  intending to be legally bound, the parties hereto hereby agree as
follows:

1.  EMPLOYMENT.  The Company  hereby  employs  Executive  as Chairman  and Chief
Executive Officer ("CEO") of the Company. Executive hereby agrees to be employed
by the Company in such capacity and to discharge and perform  faithfully  and to
the best of his ability such duties and services of an executive, administrative
and managerial nature consistent with the positions of Chairman and CEO as shall
be specified and  determined  from time to time by the Board of Directors of the
Company (the "Board") in connection with the Business.

2.  DUTIES.  During  the term of this  Agreement,  Executive,  as the  Company's
Chairman and CEO, shall devote  substantially  all of his business time,  skill,
labor  and  attention  to the  affairs  of the  Company  in  furtherance  of the
Business. Without limiting the foregoing, Executive shall report directly to the
Board and shall be subject to the general direction and control of the Board.

3. WORKING  FACILITIES.  Executive  shall be furnished with working  facilities,
including office space,  secretarial services and other services suitable to his
position  and  adequate  for  the  performance  of  his  duties,  as  reasonably
determined by the Company.

4. TERM. (a) Executive's  employment  under this Agreement shall commence on the
Effective  Date and shall continue for an initial period of three (3) years (the
"Initial Employment  Period"),  unless earlier terminated by Executive or by the
Company pursuant to the provisions hereof.

     (b)  This  Agreement  shall  automatically  be  renewed  at the  end of the
          Initial  Employment  Period  for one  additional  (3) year  period  in
          accordance  with the  terms  and  conditions  set  forth  herein  (the
          "Renewal  Period")  unless  either party gives  written  notice to the
          other not later than nine (9) months  prior to the  expiration  of the
          Initial Employment Period.

5. COMPENSATION AND RELATED MATTERS.

     (a)  Base Salary - The Company shall pay Executive a base salary (the "Base
          Salary") for his services  hereunder in accordance with the provisions
          set forth below:  (i) for the first year of employment,  commencing on
          the Effective Date and ending on October 30, 2001,  (the "First Year")
          the amount of Four Hundred Thousand Dollars ($400,000) per annum; (ii)
          for the second year of employment, commencing on October 31, 2001, and
          ending on October 30,  2002,  (the  "Second  Year") the amount of Four
          Hundred Fifty Thousand  Dollars  ($450,000)  per annum;  (iii) for the
          third year of  employment,  commencing on October 31, 2002, and ending
          on October  30, 2003 (the "Third  Year"),  the amount of Five  Hundred
          Thousand  Dollars  ($500,000)  per  annum.  The Base  Salary  shall be
          subject to withholding for appropriate taxes as required by applicable
          law,  and shall be  payable in  approximately  equal  installments  in
          accordance with the Company's customary payroll practices but not less
          frequently than semi-monthly.

     (b)  Bonus - (i) During the Initial Employment  Period,  Executive shall be
          entitled to a yearly bonus (the "Bonus") payable in cash in accordance
          with the provisions set forth below: (1) for the First Year the amount
          of Two Hundred Thousand  Dollars  ($200,000) (the "First Year Bonus");
          and (2) for each of the  Second  and Third  Years,  the  amount of the
          Bonus  (each such bonus,  the  "Second  Year Bonus" or the "Third Year
          Bonus") shall be based on the Company's  achievement of goals mutually
          agreed upon by Executive and the Board;  provided,  however, that: (A)
          the amount of each of the  Second  Year Bonus and the Third Year Bonus
          shall not be less than  twenty-five  percent  (25%) of the Base Salary
          for the applicable  year of employment;  (B) the target amount of each
          of the  Second  Year  Bonus and the Third  Year  Bonus  shall be fifty
          percent  (50%)  of  the  Base  Salary  for  the  applicable   year  of
          employment;  and (C) the  maximum  amount of each of the  Second  Year
          Bonus and the Third Year Bonus  shall not exceed one  hundred  percent
          (100%) of the Base Salary of the applicable year of employment.

     (ii) In addition to the  amounts  set forth in  Paragraphs  5(a) and (b)(i)
          above,  Executive shall be entitled to a one-time `sign-on' bonus (the
          "Sign-On  Bonus")  in the  amount  of  One  Hundred  Thousand  Dollars
          ($100,000) payable on the Effective Date.

     (c)  Benefits - During the Initial  Employment  Period and Renewal  Period,
          Executive  shall be entitled to  participate  in all employee  benefit
          plans and programs,  to the same extent  generally  available to other
          similarly situated Company executives, in accordance with the terms of
          those  plans  and  programs.  The  Company  shall  have  the  right to
          terminate or change any such plan or program at any time.

     (d)  Expenses - The Company shall  reimburse  Executive for all  reasonable
          and customary travel,  business and entertainment expenses incurred in
          connection with Executive's  title and the performance of his services
          hereunder in accordance  with the policies and procedures  established
          by the Company.

     (e)  Vacation - Executive shall be entitled to annual paid vacation time of
          four (4)  weeks,  accruing  ratably  over the  course  of each year of
          employment, to be taken at such time or times as Executive may select,
          consistent with his obligations hereunder. Any vacation days not taken
          during an applicable  fiscal year may be carried over to the following
          fiscal year pursuant to the Company's existing plan.

     (f)  Stock Grant - On the Effective  Date,  Executive shall be granted (the
          "Stock Grant") twenty five thousand (25,000)  restricted shares of the
          Company's  common  stock (the  "Restricted  Shares").  The  Restricted
          Shares shall vest as follows:  (i) one-third  (1/3) of the  Restricted
          Shares on January  1, 2001;  (ii)  one-third  (1/3) of the  Restricted
          Shares on January 1, 2002; and (iii) one-third (1/3) of the Restricted
          Shares on January 1, 2003. The  Restricted  Shares shall be subject to
          the terms and conditions set forth on Exhibit A hereto.

          In  addition  to the  foregoing,  the  Company  shall  pay  Executive,
          promptly, a payment in an amount equal to Executive's  "Grossed-Up Tax
          Liability." The term "Grossed-Up Tax Liability" means an amount which,
          after  Executive's  payment  of  federal,  state and local  income tax
          liabilities  arising upon his receipt of the  Grossed-Up Tax Liability
          payment,  shall equal the amount of the "Stock  Grant Tax  Liability."
          The term "Stock  Grant Tax  Liability"  shall mean the sum of federal,
          state and local income tax liability which is payable by Executive due
          to his receipt of the Stock Grant at the time the liability arises.

     (g)  Stock Option - On the  Effective  Date (the "Grant  Date"),  Executive
          shall be  granted  an option or  options  (the  "Initial  Option")  to
          purchase:  (i) five hundred thousand (500,000) shares of the Company's
          common  stock (the  "Initial  Common  Stock") at an exercise  price of
          $12.50 per share,  the closing  price as reported by Nasdaq on October
          30, 2000;  and (ii) upon the Company's  achievement  of goals mutually
          agreed  to by the  Board  and  Executive,  during  the  Term  of  this
          Agreement,  Executive  shall be  granted  an  option or  options  (the
          "Subsequent  Options,"  together with the Initial  Option,  the "Stock
          Options") to purchase a minimum of an  additional  one hundred  twenty
          five  thousand  (125,000)  shares of the  Company's  common stock (the
          "Subsequent  Common  Stock") per year of  employment  beginning on the
          first  anniversary  of the Effective  Date (each such  anniversary,  a
          "Subsequent  Grant Date"),  at an exercise  price equal to the closing
          price as reported by Nasdaq on each such  Subsequent  Grant Date.  The
          Initial Option and each Subsequent  Option shall vest in equal amounts
          on a monthly  basis over a three (3) year  period  from the Grant Date
          and  each  Subsequent  Grant  Date,  respectively,  and  shall  remain
          exercisable  for a period of ten (10)  years  from the Grant  Date and
          each Subsequent Grant Date,  respectively.  The Stock Options shall be
          granted in accordance  with the Company's  1997 Employee  Stock Option
          Plan (or a  successor  plan  thereto)  (the  "Plan"),  and  except  as
          specifically  set forth in this  Agreement,  in the case if a conflict
          between  this  Agreement  and the terms of the Plan,  the terms of the
          Plan shall govern.

     (h)  Relocation  - (i)  The  Company  shall  reimburse  Executive  for  any
          expenses  incurred  in  connection  with the  purchase  of a residence
          within commuting  distance of the Company  including,  but not limited
          to: (1) costs (other than the purchase price) associated with the sale
          and  purchase  of  Executive's  house  including,  but not limited to,
          realtor  expenses;  (2) the moving of household  goods; (3) the moving
          trip;  (4)  trips  to the new  location  for,  among  other  purposes,
          purchasing  a  residence;  and (5) lodging and car  expenses  incurred
          during trips to the new location.  If any such reimbursement  shall be
          subject to income tax, the Company shall make such additional  payment
          to  Executive  so that the net after  tax  payment  to him under  this
          Paragraph 5(h) shall not be less than the expenses to be reimbursed.

     (ii) The Company shall provide  Executive with a loan of up to $1.5 million
          (with  interest  deferred)  for the purpose of  purchasing a residence
          (the "Loan") in connection with the relocation  described in Paragraph
          5(h)(i) above. The Loan shall be secured by the residence purchased by
          Executive with the Loan (the  "Residence").  The maximum amount of the
          Loan will be reduced by any  temporary  lodging and  related  expenses
          incurred  by  Executive  and  paid by the  Company.  Upon  the sale of
          Initial  Common  Stock or  Subsequent  Common  Stock,  pursuant to the
          exercise of any vested Stock  Option,  fifty  percent (50%) of the net
          after tax proceeds  therefrom shall be used to repay the Loan,  unless
          circumstances  described in Paragraphs 6 or 8(b) below occur. Upon the
          sale,  encumbrance  or  other  transfer  of  the  Residence,   whether
          voluntary,  involuntary or by operation of law, Executive will pay the
          Company the remaining  principal amount due on the Loan, together with
          any interest  deferred and accrued  thereon.  Any remaining  principal
          amount  due on the  Loan,  together  with any  interest  deferred  and
          accrued  thereon,  shall become due and payable in full to the Company
          on October 31,  2004;  provide,  however,  that if this  Agreement  is
          renewed  pursuant to Paragraph  4(b) above,  such amounts shall become
          due and payable in full on October 31, 2006.

6. CHANGE IN CONTROL.

     (a)  For the purposes of this Agreement, the term "Change in Control" shall
          mean the occurrence of any of the following events with respect to the
          Company:

     (i)  All or  substantially  all of the  assets of the  Company  are sold or
          transferred  to another  corporation  or entity,  with the result that
          upon  conclusion  of  the  transaction  less  than a  majority  of the
          outstanding  securities  entitled to vote generally in the election of
          directors or other capital  interests of the acquiring  corporation or
          entity are owned,  directly or indirectly,  by the shareholders of the
          Company   immediately   prior   to   the   sale,   transfer,   merger,
          consolidation, venture or reorganization;

     (ii) The Company is sold, transferred,  merged,  consolidated,  ventured or
          reorganized  into or with  another  corporation  or  entity,  with the
          result  that  upon  the  conclusion  of the  transaction  less  than a
          majority of the outstanding  securities  entitled to vote generally in
          the election of directors or other capital  interests of the acquiring
          corporation  or entity  are  owned,  directly  or  indirectly,  by the
          shareholders of the Company  immediately prior to the sale,  transfer,
          merger, consolidation, venture or reorganization:

     (iii)There is a report  filed on  Schedule  13D or  Schedule  14D-1 (or any
          successor schedule,  form or report),  each as promulgated pursuant to
          the Securities  Exchange Act of 1934, as amended (the "Exchange Act"),
          disclosing  that any person (as the term  "person"  is used in Section
          13(d)(3)  or  Section  14(d)(2)  of the  Exchange  Act) has become the
          beneficial  owner (as the term  "beneficial  owner") is defined  under
          Rule 13d-3 or any successor rule or regulation  promulgated  under the
          Exchange Act) of securities representing more than fifty percent (50%)
          of the combined voting power of the then-outstanding voting securities
          of the Company; or

     (iv) The Company shall file a report or proxy statement with the Securities
          and Exchange  Commission  pursuant to the Exchange Act  disclosing  in
          response to Item 1 of Form 8-K  thereunder  or Item 14 of Schedule 14A
          thereunder (or any successor schedule, form or report or item therein)
          that a change in control of the Company has or may have occurred.

     (b)  The  "Change  Date"  shall be the date on which a Change in Control of
          the Company, as described in Paragraph 6(a) above, occurs.

     (c)  The term  "Discharge"  shall mean the  termination  by the  Company of
          Executive's   employment  following  the  Change  in  Control  or  the
          resignation of Executive upon a reasonable  determination by Executive
          that,  as  a  result  of  the  Change  in  Control  and  a  change  in
          circumstances  thereafter  significantly affecting his position, he is
          unable  to  exercise  the  authorities,  powers,  functions  or duties
          attached to his position as contemplated by Paragraph 2 herein.

     (d)  In the event of a Discharge:

     (i)  the Company shall pay Executive an amount such that the net payment to
          Executive after deduction of all payroll taxes and all income taxes at
          the highest  marginal rates  applicable to Executive shall be equal to
          twice the Base Salary and twice the Bonus  payable to Executive in the
          year in which the Change Date occurs.

     (ii) The Restricted  Shares shall vest and Executive shall be entitled to a
          Registration  Right (as such term is defined in Paragraph  8(d) below)
          with respect  thereto,  and the Stock Options shall vest on the Change
          Date;  provided,  however,  that the  exercise  period  for the  Stock
          Options  shall be subject to the greater of that  provided  for by the
          Plan or that  provided for by the  acquiring  company in the Change in
          Control.

     (iii)Executive  shall  continue to be entitled  to the  benefits  under any
          employee  benefit  plans to which he was  entitled  during the Initial
          Employment  Period or Renewal  Period for the remainder of the Initial
          Employment Period or Renewal Period hereunder, respectively.

     (iv) Any  principal or interest  amounts due under the Loan provided for in
          Paragraph  5(h)(ii)  above,  if any,  shall be forgiven  in full.  The
          Company  shall pay  Executive  an amount  such that the net payment to
          Executive after deduction of all income taxes at the highest  marginal
          rates  applicable  to  Executive  shall be equal to the  amount of the
          Loan.

7. TERMINATION.  Executive's  employment  hereunder may be terminated during the
Initial Employment Period or Renewal Period under the following circumstances in
accordance with the provisions of this Paragraph:

     (a)  Executive's  employment will  immediately  terminate upon the death of
          Executive.  Executive's  legal  representatives  shall be  entitled to
          receive  the salary due  Executive  through  the last day of the month
          during which his death shall have occurred and any annual Bonus earned
          for the year through the date on which his death shall have occurred.

     (b)  (i) The Company may  terminate  Executive's  employment  pursuant to a
          written  notice (a "Notice of  Termination")  at least sixty (60) days
          prior to the date of  termination  (the  "Date of  Termination")  as a
          result of Executive's  inability to perform his duties hereunder,  due
          to physical or mental illness, injury or condition, as determined by a
          physician certified by the Company, for a period exceeding one hundred
          and eighty (180) days, in a three hundred sixty-five (365) day period.

     (ii) This  Agreement  shall remain valid and in full force and effect until
          the  Date  of  Termination  in  the  event  that  circumstances  under
          Paragraph 7(b)(i) above occur.

     (c)  The Company may terminate Executive's  employment for "Cause" pursuant
          to a Notice of Termination  delivered to Executive at least sixty (60)
          days  prior  to the  Date of  Termination.  For the  purposes  of this
          Agreement, "Cause" shall mean:

     (i)  Executive's  willful failure or refusal to perform  specific  material
          directives of the Board, when such material  directives are consistent
          with the scope and nature of Executive's  duties and  responsibilities
          as set forth in Paragraph 2 above, after notice thereof,  stating with
          specificity the nature of such failure or refusal, and Executive shall
          have failed to correct such failure or to cease such refusal  prior to
          the Date of  Termination  provided  for in the Notice of  Termination;
          provided,  however  that  no  failure  to act by  Executive  shall  be
          considered "willful" if such failure to act is due to Executive's good
          faith  belief  that such  action  would be  materially  harmful to the
          Company;

     (ii) Executive's  material  failure to comply with policies of the Company,
          after  notice  thereof,  stating with  specificity  the nature of such
          failure, and Executive shall have failed to correct such failure or to
          cease such refusal  prior to the Date of  Termination  provided for in
          the Notice of Termination;

     (iii)drunkenness or use of drugs which  interferes  with the performance of
          Executive's duties and  responsibilities  hereunder,  continuing after
          warning;

     (iv) Executive's  conviction  of a felony or of any crime  involving  moral
          turpitude, fraud or misrepresentation; or

     (v)  Executive's  material  breach  of  his  obligations  provided  for  in
          Paragraph 11 below.

     (d)  Executive  may  terminate  his  employment  hereunder by providing the
          Company with a Notice of Termination  delivered  sixty (60) days prior
          to the  Date  of  Termination  upon  the  occurrence  of an  event  or
          circumstance  constituting  Good  Reason.  For  the  purposes  of this
          Agreement  "Good  Reason"  shall  mean  the  occurrence  of any of the
          following  without the written consent of Executive or his approval in
          his capacity as Chairman of the Board and/or Chief Executive Officer:

     (i)  the assignment to Executive of duties inconsistent with this Agreement
          or a material and substantial diminution of his duties hereunder;

     (ii) any material failure by the Company to comply with Paragraph 5 herein;

     (iii)the  requirement  of Executive to relocate to a location not agreed to
          by  Executive  and  which  is  unreasonable   considering  Executive's
          personal circumstances; and

     (iv) any material breach of this Agreement by the Company;

          provided  however,  that an  event  that is or would  constitute  Good
          Reason shall cease to be Good Reason if: (1) Executive does not send a
          Notice of Termination to the Company within forty-five (45) days after
          the event  occurs;  (2) the Company  reverses  the action or cures the
          default that constitutes Good Reason within forty-five (45) days after
          the  delivery of the Notice of  Termination;  or (3)  Executive  was a
          primary instigator of the Good Reason event and the circumstances make
          it inappropriate for him to receive Good Reason  resignation  benefits
          under this Agreement.

8. COMPENSATION UPON TERMINATION.

     (a)  Termination  for  Cause  or  Resignation  without  Good  Reason  -  If
          Executive's  employment shall be terminated for Cause, or without Good
          Reason:  (i) the Company shall pay Executive his Base Salary up to the
          date on which a Notice of Termination is delivered;  (ii) the unvested
          portion of the Stock Grant and any unvested Stock Options shall remain
          unvested and shall no longer be  exercisable  by Executive;  and (iii)
          neither  Executive nor the Company  shall have any further  obligation
          hereunder other than Executive's obligations under Paragraph 11 below.

     (b)  Termination  without  Cause or  Resignation  with Good Reason - In the
          event that this  Agreement is terminated by the Company  without Cause
          or by Executive with Good Reason:

     (i)  Executive  shall be entitled to an amount such that the net payment to
          Executive after deduction of all payroll taxes and all income taxes at
          the highest  marginal rates  applicable to Executive shall be equal to
          either:  (A) twice the Base  Salary  for the First  Year and twice the
          First Year Bonus, if said termination of employment  occurs during the
          First Year;  or (B) the Base Salary and the Bonus  payable in any year
          subsequent to the First Year, if the termination of employment  occurs
          during any such subsequent year;

     (ii) One  hundred  percent  (100%)  of the  Stock  Grant  shall  vest,  and
          Executive  shall be entitled to a Registration  Right (as such term is
          defined in Paragraph 8(d) below) with respect thereto;

     (iii)Any  principal or interest  amounts due under the Loan provided for in
          Paragraph 5(h)(ii) above, if any, shall be forgiven in full;  provided
          further that if, and only if, Executive's  employment is terminated by
          the Company  without  Cause or by Executive  with Good Reason prior to
          the  second   anniversary  of  this   Agreement,   the  Company  shall
          additionally  pay  Executive  an amount  such that the net  payment to
          Executive after deduction of all income taxes at the highest  marginal
          rates  applicable  to  Executive  shall be equal to the  amount of the
          Loan;

     (iv) the exercise period for all vested Stock Options shall be one (1) year
          from the Date of Termination;

     (v)  any unvested Stock Options  remaining  unvested in the month after the
          Date of  Termination  shall  remain  unvested  and  shall no longer be
          exercisable by Executive; and

     (vi) Executive  shall  continue to be entitled  to the  benefits  under any
          employee  benefit  plans to which he was  entitled  during the Initial
          Employment  Period or Renewal  Period for the remainder of the Initial
          Employment Period or Renewal Period, respectively, hereunder.

     (c)  The  Non-Renewal  of this Agreement - In the event that this Agreement
          shall not be renewed at the end of the  Initial  Employment  Period as
          specified in Paragraph 4(b) herein: (i) Executive shall be entitled to
          receive  an  amount  such  that the net  payment  to  Executive  after
          deduction  of all  payroll  taxes and all income  taxes at the highest
          marginal  rates  applicable  to  Executive  shall be equal to the Base
          Salary  in the Third  Year and Third  Year  Bonus;  (ii) the  exercise
          period for any  vested  Stock  Options  shall be one (1) year from the
          Date of  Termination;  (iii) any unvested  Stock  Options shall remain
          unvested and shall no longer be  exercisable  by  Executive;  and (iv)
          upon the sale of Initial  Common  Stock or  Subsequent  Common  Stock,
          pursuant to the exercise of any vested  Stock  Option,  fifty  percent
          (50%) of the net after tax proceeds  therefrom  shall be used to repay
          any  remaining  principal and interest due under the Loan provided for
          in Paragraph 5(h)(ii) herein.

     (d)  Registration  Right - The  "Registration  Right" shall consist of: (i)
          one demand  registration  on Form S-3 (or a  successor  form  thereto)
          covering any of Executive's unregistered securities which shall remain
          effective  for not  more  than  thirty  (30)  days;  (ii)  payment  of
          customary  registration  expenses,  by the  Company;  (iii)  customary
          indemnification  and contribution;  and (iv) other usual and customary
          terms then  being  included  in  agreements  of that  type;  provided,
          however,  that  Executive  shall not be entitled  to any  Registration
          Right if he may otherwise sell his unregistered securities pursuant to
          an exemption under Rule 144.

9. RENEWAL PERIOD.  Prior to the Renewal Period,  the Base Salary,  Bonus, Stock
Grant, and Stock Options will be determined by the Company and Executive in good
faith  negotiation  no later than nine (9) months prior to the expiration of the
Initial  Employment  Period but in no event will the Base Salary,  Bonus,  Stock
Grant,  and Stock Options  during the Renewal Period be less than the Third Year
Salary  and Bonus and the first year Stock  Grant and Stock  Option as  provided
herein for the Initial Employment Period.

10. LIFE INSURANCE.  The Company may, in its  discretion,  at any time after the
Effective  Date,  apply  for and  procure  as  owner  and  for its own  benefit,
insurance on the life of Executive, in such amounts and in such form or forms as
the Company may choose.  Executive shall have no interest whatsoever in any such
policy or  policies.  At the request of the Company,  Executive  shall submit to
such medical examinations,  supply such information,  and execute such documents
as may be required by the  insurance  company or  companies to which the Company
has applied for such insurance.

11. CONFIDENTIALITY.

     (a)  Non-disclosure  -  Executive  shall not at any time during the term of
          this Agreement or thereafter, either directly or indirectly,  disclose
          or  divulge  to any  other  person,  firm or  corporation  the  names,
          addresses, preferences, prices being charged or any other confidential
          information  concerning  or  relating to any of the former or existing
          suppliers, contractors,  employees or customers of the Company, or any
          parent,  affiliate or  subsidiary  of the Company  (collectively,  the
          "Customers")  with respect to the past,  present or future business of
          the Company, or any parent, affiliate or subsidiary of the Company, or
          any secret,  proprietary  or  confidential  information  concerning or
          relating to the past,  present or future  business of the Company,  or
          any parent,  affiliate  or  subsidiary  of the Company  (collectively,
          "Confidential  Information"),  and he will not  divert or  attempt  to
          divert  any of the  Customers  or do any act to impair,  prejudice  or
          destroy  the  goodwill of the Company  with the  Customers;  provided,
          however,  Confidential Information shall not include information which
          was known to the public prior to the date of communication  thereof by
          the Company to  Executive  or which  subsequently  became known to the
          public  other  than  through  communication  by  Executive;  provided,
          further, such Confidential Information shall include, but shall not be
          limited to:

     (i)  information regarding the Company's proprietary research,  technology,
          trade  secrets,  patented  processes,  market  studies and  forecasts,
          competitive  analyses,  pricing policies,  the substance of agreements
          with customers, suppliers and others, marketing arrangements, training
          programs and arrangements,  and other  information,  written and oral,
          relating  to  the  Company's  technology,  systems  and  products  not
          generally available to the public;

     (ii) information regarding the Company's  trademarks,  trade names, service
          marks, or patents;

     (iii)the Company's  equipment,  management,  internal  policies,  and other
          activities relating to the conduct of the Company's Business; and

     (iv) other  data,   developments,   research,  trade  secrets,  methods  or
          techniques used by the Company in the conduct of its Business.

     (b)  Ownership of Intellectual Property - Executive acknowledges and agrees
          that all  intellectual  property  (including  without  limitation  all
          ideas, concepts,  inventions,  plans,  developments,  software,  data,
          configurations,   materials  (whether  written  or  machine-readable),
          designs,  drawings,   illustrations  and  photographs,  which  may  be
          protectable,  in  whole  or in  part,  under  any  patent,  copyright,
          trademark,   trade  secret  or  other   intellectual   property  law),
          developed,  created, conceived, made or reduced to practice during his
          employment  with the  Company or the Parent  which:  (a) relate to the
          current,  future or  potential  business of the Company or the Parent;
          (b) result from the duties or work  performed by Executive  hereunder;
          or (c) are  developed  during  working  time or  using  the  Company's
          equipment, supplies, facilities,  resources, materials or information,
          shall be the sole and exclusive property of the Company, and Executive
          shall and hereby does assign all right,  title and  interest in and to
          such intellectual property to the Company.

     (c)  Nonsolicitation - Because Executive's solicitation of the Customers of
          the Company,  or any parent,  affiliate or  subsidiary of the Company,
          under  certain  circumstances  would  necessarily  involve  the use or
          disclosure of  Confidential  Information,  Executive shall not, either
          directly or indirectly,  at any time during the term of this Agreement
          and for a period of one (1) year from the Date of  Termination  or the
          date of expiration  of this  Agreement:  (a) call on,  solicit or take
          away, or attempt to call on, solicit or take away, any past or present
          Customers of the Company,  or any parent,  affiliate or  subsidiary of
          the Company;  (b) employ, hire or solicit the employment of any person
          employed by the Company, or any parent, affiliate or subsidiary of the
          Company;  (c) do any act to impair,  prejudice or destroy the goodwill
          of the Company, or any parent, affiliate or subsidiary of the Company,
          or to  prejudice  or impair the  relationship  or dealing  between the
          Company,  or any parent,  affiliate or subsidiary of the Company,  and
          the Customers;  or (d) assist any other person, firm or corporation in
          any such acts.

     (d)  Other  Employment - Executive  agrees that, while this Agreement is in
          effect and for twelve (12) months after its  termination,  he will not
          accept any  employment or engage in any activity,  without the written
          consent of the Board,  if the loyal and  complete  fulfillment  of his
          duties would inevitably require him to reveal or utilize  Confidential
          Information that Executive has promised not to disclose, as reasonably
          determined by the Board.

     (e)  Return  of  Confidential  Information  -  Promptly  after  the Date of
          Termination or expiration of this Agreement, Executive will deliver to
          the  Company or, at its written  instruction,  destroy all  documents,
          data, drawings,  manuals,  letters,  notes, reports,  electronic mail,
          recordings, and copies thereof, in his possession or control.

     (f)  Promise  to  Discuss  Proposed  Actions in  Advance-  To  prevent  the
          inevitable  use  or  disclosure  of  trade  secrets  or   Confidential
          Information,  Executive  promises that, before Executive  discloses or
          uses   information   and  before   Executive   commences   employment,
          solicitations,  or any other activity that could possibly  violate the
          terms of this Paragraph,  Executive will discuss his proposed  actions
          with the Board,  which will  advise  Executive  whether  his  proposed
          actions would violate this Paragraph.

     (g)  Survival and  Enforcement - The  provisions of this Paragraph 11 shall
          survive the termination of this Agreement,  irrespective of the reason
          therefor.  Executive  acknowledges  that:  (i) his  services  are of a
          special,  unique,  and  extraordinary  character  and it would be very
          difficult or impossible to replace his services; (ii) this Paragraph's
          terms are reasonable and necessary to protect the Company's legitimate
          interests  (iii)  this  Paragraph's   restrictions  will  not  prevent
          Executive from earning or seeking a livelihood;  (iv) this Paragraph's
          restrictions   shall  apply   wherever   permitted  by  law;  and  (v)
          Executive's   violation  of  any  of  this  Paragraph's   terms  would
          irreparably  harm the  Company.  Accordingly,  Executive  agrees that,
          notwithstanding any other Paragraph of this Agreement,  if he violates
          any of the provisions of this Paragraph, the Company shall be entitled
          to, in addition to other remedies available to it, an injunction to be
          issued by any court of competent  jurisdiction  restraining  Executive
          from committing or continuing any such violation,  without the need to
          post any bond or for any other  undertaking or prove the inadequacy of
          money damages.

12. MISCELLANEOUS.

     (a)  Notices to be given in writing shall be transmitted  by Facsimile,  by
          personal  delivery or by certified  mail,  return  receipt  requested,
          addressed  as set forth  below or to  another  address  given  through
          written notice under the provisions of this Paragraph:

          If to the Company:

                          BioMarin Pharmaceutical Inc.
                          Attention: Board of Directors
                          371 Bel Marin Keys, Suite 210
                          Novato, California 94949

          If to Executive:

                           Fredric D. Price
                           64 Quarry Lane
                           Bedford, New York 10506

          Notice  shall be deemed  to have  been  given  when  delivered  or, if
          earlier (1) when mailed by United States certified or registered mail,
          return  receipt  requested,   postage  prepaid,   or  (2)  faxed  with
          confirmation  of delivery,  in either  case,  addressed as required in
          this Paragraph.

     (b)  This Agreement  shall be governed by and construed in accordance  with
          the internal,  substantive  laws of the State of California.  Venue of
          any  proceeding  shall be  exclusively  in the  County of Marin in the
          foregoing  state,  and both parties  hereby  consent and agree to such
          exclusive venue.

     (c)  Except as explicitly set forth in this Agreement, all disputes between
          Executive and the Company  arising under this Agreement or relating to
          Executive's  employment or  termination  thereof are to be resolved by
          final and binding  arbitration in accordance with the commercial rules
          of the  American  Arbitration  Association  in the  County of Marin in
          California.  The  parties  agree  that the  awarding  of any costs and
          expenses,  including  attorney's fees,  incurred in such  arbitration,
          shall be determined by the arbitrators. This Paragraph shall remain in
          effect after the termination of this Agreement.

     (d)  This  Agreement  may be  executed  simultaneously  in two  (2) or more
          counterparts, each of which shall be deemed to be an original, but all
          of which  together shall  constitute one (1) and the same  instrument.
          Furthermore,  facsimiles  of  signatures  may be taken  as the  actual
          signatures,  and each party agrees to furnish the other with documents
          bearing the original  signatures within ten (10) days of the facsimile
          transmission.

     (e)  This  Agreement,  including the exhibits  hereto,  contains the entire
          understanding  between the parties  hereto with respect to the subject
          matter hereof and supersedes any prior  agreements and  understandings
          relating thereto. This Agreement may not be waived, changed, modified,
          extended or discharged orally, but only by a written instrument signed
          by  the  party  against  whom  enforcement  of  any  waiver,   change,
          modification, extension or discharge is sought.

     (f)  The invalidity or  unenforceability of any provision of this Agreement
          shall not affect the validity or enforceability of any other provision
          of this Agreement, which shall remain in full force and effect.

     (g)  Executive  represents  that  he is  not  subject  to  any  employment,
          confidentiality,  or other agreement or restriction that would prevent
          him from fully  satisfying  his duties  under this  Agreement  or that
          would be violated if he did so.  Without the  Company's  prior written
          approval, Executive agrees not to:

     (i)  disclose  proprietary  information  belonging to a former  employer or
          other entity without its written permission;

     (ii) contact any former employer's  customers or employees to solicit their
          business or employment on behalf of the Company; or

     (iii)distribute  announcements  about or otherwise publicize his employment
          with the Company.

          Executive  agrees to indemnify and hold the Company  harmless from any
          liabilities,  including  defense  costs,  it may incur  because  he is
          alleged to have broken any of these promises or improperly revealed or
          used such  proprietary  information or to have threatened to do so, or
          if a former  employer  challenges  his entering into this Agreement or
          rendering services pursuant to it.

     (h)  Executive  agrees that any payments and benefits  under this Agreement
          and all other contracts,  arrangements,  or programs shall not, in the
          aggregate,  exceed the maximum  amount that may be paid to him without
          triggering  golden parachute  penalties under Section 280G and related
          provisions  of the Internal  Revenue Code, as determined in good faith
          by the  Company's  independent  auditors.  If any benefits must be cut
          back to avoid  triggering  such  penalties,  the benefits shall be cut
          back in the priority order designated by the Company.  If an amount in
          excess of the limit set forth in this  Paragraph is paid to Executive,
          Executive  agrees  to repay the  excess  amount  to the  Company  upon
          demand,  with  interest at the rate  provided for in Internal  Revenue
          Code  Section  1274(b)(2)(B).  The  Company  and  Executive  agree  to
          cooperate  with each other in connection  with any  administrative  or
          judicial  proceedings  concerning  the  existence  or amount of golden
          parachute  penalties with respect to payments or benefits  received by
          Executive.

<PAGE>



         IN WITNESS WHEREOF, the parties have duly executed this Agreement as of
the date first above written.

BIOMARIN PHARMACEUTICAL INC.                  EXECUTIVE:
By:_________________________                  ___________________________
Company Title:______________                  Fredric D. Price


<PAGE>
                                    EXHIBIT A
                   TERMS AND CONDITIONS OF RESTRICTED SHARES

1.       SECURITIES LAW COMPLIANCE

(a) Restricted Securities.  The Restricted Shares have not been registered under
the Securities Act of 1933, as amended (the "1933 Act"). By his signature on the
Employment Agreement, Executive hereby confirms that Executive has been informed
that the Restricted Shares are restricted  securities under the 1933 Act and may
not be sold or  transferred  unless the Restricted  Shares are first  registered
under the federal  securities laws or unless an exemption from such registration
is available.

(b) Restrictions on Disposition of Restricted  Shares.  Executive shall not make
transfer or sell the Restricted  Shares or any interest therein unless and until
the  Restricted  Shares have  vested.  The Company  shall not be required (i) to
transfer on its books any Restricted  Shares which have been sold or transferred
in  violation of the  provisions  of this  Agreement  (and the Company may issue
appropriate "stop transfer"  instructions to its transfer agent  accordingly) or
(ii) to treat as the owner of the  Restricted  Shares,  or  otherwise  to accord
voting, dividend or liquidation rights to, any transferee to whom the Restricted
Shares have been transferred in contravention of this Agreement.

2.       TRANSFER RESTRICTIONS

(a) Restriction on Transfer. Executive shall not sell, transfer, assign, pledge,
encumber or otherwise  dispose of any of the Restricted  Shares that are subject
to the Repurchase Right (as defined below).

3.       REPURCHASE RIGHT

(a) Repurchase Option. If the events described in Paragraph 8(a) above occur and
the Employment  Agreement shall be terminated for Cause, or without Good Reason,
before all of the Shares are released  from the Company's  Repurchase  Right (as
defined below),  the Company shall, upon the date of such termination,  have the
right to  repurchase  up to that number of unvested  shares at the  original par
value per share of $0.001 (the "Repurchase  Right").  The Repurchase Right shall
be exercised by the Company by delivering written notice to the Executive.  Upon
delivery of such notice, the Company shall become the legal and beneficial owner
of the Shares being repurchased and all rights and interests therein or relating
thereto,  and the Company shall have the right to retain and transfer to its own
name the number of Shares being repurchased by the Company.

(b)  Termination  of the  Repurchase  Right.  (i)  The  Repurchase  Right  shall
terminate  and cease to be  exercisable  with respect to any and all  Restricted
Shares which have vested in  accordance  with the vesting  schedule set forth in
Paragraph 5(f) of the Agreement;

(ii) The  Repurchase  Right shall  terminate  and cease to be  exercisable  with
respect to all Restricted  Shares if Executive  becomes entitled to compensation
under Paragraphs 6(d)(ii) or 8(b)(ii) of the Agreement.

4.       LEGENDS

(a) Legends.  The share  certificate  evidencing the Restricted  Shares,  issued
hereunder shall be endorsed with the following legends, or legends substantially
equivalent  thereto (in addition to any legend required under  applicable  state
securities laws):

     THE  SECURITIES  REPRESENTED  HEREBY  HAVE NOT BEEN  REGISTERED  UNDER  THE
     SECURITIES ACT OF 1933, AS AMENDED (THE "ACT") AND MAY NOT BE OFFERED, SOLD
     OR  OTHERWISE  TRANSFERRED,   PLEDGED  OR  HYPOTHECATED  UNLESS  AND  UNTIL
     REGISTERED  UNDER  THE ACT OR, IF IN THE  OPINION  OF  COUNSEL  IN FORM AND
     SUBSTANCE SATISFACTORY TO THE ISSUER OF THESE SECURITIES, SUCH OFFER, SALE,
     TRANSFER, PLEDGE OR HYPOTHECATION IS IN COMPLIANCE THEREWITH.

     THE  SHARES   REPRESENTED  BY  THIS  CERTIFICATE  ARE  SUBJECT  TO  CERTAIN
     RESTRICTIONS  UPON  TRANSFER AND A RIGHT OF  REPURCHASE  AS SET FORTH IN AN
     AGREEMENT  BETWEEN THE COMPANY AND THE  SHAREHOLDER,  A COPY OF WHICH IS ON
     FILE WITH THE SECRETARY OF THE COMPANY.

(b)      Investment Intent. Executive represents to the Company the following:

(i) Executive is acquiring  these  Securities for investment for Executive's own
account  only and not with a view to, or for  resale  in  connection  with,  any
"distribution" thereof within the meaning of the 1933 Act.

(ii) Executive  acknowledges  and  understands  that the  Securities  constitute
"restricted securities" under the Act and have not been registered under the Act
in reliance upon a specific exemption  therefrom,  which exemption depends upon,
among other things,  the bona fide nature of  Executive's  investment  intent as
expressed herein. Executive further understands that the Securities must be held
indefinitely  unless  they  are  subsequently  registered  under  the  Act or an
exemption from such registration is available.  Executive  further  acknowledges
and  understands  that the  Company  is  under no  obligation  to  register  the
Securities, except as set forth in the Agreement.

(iii)  Executive  hereby  agrees  that if so  requested  by the  Company  or any
representative  of the  underwriters in connection with any  registration of the
offering of any  securities  of the Company under the Act,  Executive  shall not
sell or otherwise  transfer any Shares or other securities of the Company during
a period  of up to 180  days  following  the  effective  date of a  registration
statement  of  the  Company   filed  under  the  Act.  The  Company  may  impose
stop-transfer  instructions with respect to securities  subject to the foregoing
restrictions until the end of such 180-day period.


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