ANTHRA PHARMACEUTICALS INC
RW, 1999-03-15
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                    [ANTHRA PHARMACEUTICALS, INC. LETTERHEAD]

                                 March 15, 1999


VIA EDGAR AND FACSIMILE

Securities and Exchange Commission
Division of Corporation Finance
450 Fifth Street, N.W.
Judiciary Plaza
Washington, D.C. 20549

         Re:   Anthra Pharmaceuticals, Inc.
               Request to Withdraw Registration Statement on Form S-1, as 
               amended Registration No. 333-47725

Ladies and Gentlemen:

         Anthra  Pharmaceuticals,  Inc., a Delaware corporation (the "Company"),
hereby  requests  pursuant  to Rule 477 under  the  Securities  Act of 1933,  as
amended,  to withdraw from registration the Registration  Statement on Form S-1,
including all amendments  and exhibits  thereto (the  "Registration  Statement")
(Registration  No.  333-47725),   originally  filed  by  the  Company  with  the
Securities and Exchange  Commission  (the  "Commission")  on March 11, 1998, and
thereafter  amended.  In addition,  the Company requests that its request for an
order  granting  confidential  treatment  dated March 11, 1998,  and  thereafter
amended,  be  withdrawn.  Please  return the  Company's  confidential  treatment
submissions to the address  indicated  above,  Attention:  Karen Krumeich.  This
application  has been filed  because the Company's  Board of Directors  does not
believe that the public  markets would  favorably  respond to an initial  public
offering of the Company's  securities at the current time. While the Company and
its  underwriters  circulated  preliminary  prospectuses  in connection with the
proposed offering of the Company's  securities,  the Registration  Statement was
not declared  effective by the Commission  and none of the Company's  securities
were sold pursuant to the Registration Statement.

         The Company requests that the Commission consent to this application on
the grounds that the withdrawal of the Registration Statement is consistent with
the  public  interest  and the  protection  of  investors,  as  contemplated  by
paragraph (a) of Rule 477.

         Please provide the Company with a copy of the order granting withdrawal
of the Registration Statement as soon as it is available.

         If you have any questions regarding this request for withdrawal, please
contact Joseph V. Cuomo of Morrison & Foerster LLP, counsel for the Company,  at
212-468-8177.


                           Anthra Pharmaceuticals, Inc.
                           By: /s/ Michael C. Walker 
                               Michael C. Walker
                               President and Chief Executive Officer



cc:      Jeffrey Reidler (Securities and Exchange Commission)
         Heather Maples (Securities and Exchange Commission)
         David J. Lavan (Securities and Exchange Commission)
         Joseph V. Cuomo (Morrison & Foerster LLP)
         Brian C. Daughney (Goldstein & DiGioia LLP)



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