<PAGE>
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Form 13F
Form 13F COVER PAGE
Report for the Calendar Year or Quarter Ended: June 30, 1999
-------------
Check here if Amendment [ ]; Amendment Number:
-------------
This Amendment [Check only one.]: [ ] is a restatement
[ ] adds new holdings entries
Institutional Investment Manager Filing this Report:
Name: BVF Inc.
-------------------------------------------------------------------
Address: 227 West Monroe Street, Suite 4800
-------------------------------------------------------------------
Chicago, Illinois 60606
-------------------------------------------------------------------
Form 13F File Number: 28-6800
----
The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of this form.
Person Signing this Report on Behalf of Reporting Manager:
Name: Mark N. Lampert
---------------------------------------------------------
Title: President
---------------------------------------------------------
Phone: (312) 263-7777
---------------------------------------------------------
Signature, Place and Date of Signing:
/s/ Mark N. Lampert San Francisco, California 8/16/99
------------------- --------------------------- ----------
[Signature] [City, State] [Date]
Report Type (Check only one):
[ X ] 13F HOLDINGS REPORT. (Check here if all holdings of this reporting
manager are reported in this report.)
[ ] 13F NOTICE. (Check here if no holdings reported are in this report,
and all holdings are reported by other reporting manager(s)).
<PAGE>
[ ] 13F COMBINATION REPORT. (Check here if a portion of the holdings for
this reporting manager are reported in this report and a portion are
reported by other reporting manager(s).)
Report Summary:
Number of Other Included Managers: 1
-----------------------------
Form 13F Information Table Entry Total: 34
-----------------------------
Form 13F Information Table Value Total: $144,443
-----------------------------
(thousands)
List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all
institutional investment managers with respect to which this report is filed,
other than the manager filing this report.
[If there are no entries in this list, state "NONE" and omit the column
headings and list entries.]
No. Form 13F File Number Name
1 28-6770 BVF Partners L.P.
--- ---- -----------------
<PAGE>
Page 3 of 6
FORM 13F
<TABLE>
<CAPTION>
--------------------------
(SEC USE ONLY)
NAME OF REPORTING MANAGER: BVF INC.
- ----------------------------------------------------------------------------------------------------------------------------
COLUMN 1: COLUMN 2: COLUMN 3: COLUMN COLUMN 5: COLUMN 6: COLUMN 7: COLUMN 8:
NAME OF ISSUER TITLE OF CUSIP 4: INVESTMENT OTHER VOTING AUTHORITY
CLASS VALUE DISCRETION MANAGERS
(X$1000)
---------------------- ------------------------------
SHRS SH/ PUT/ SOLE SHARED NONE
PRN PRN CALL
- ----------------------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C> <C> <C> <C> <C> <C> <C>
- ----------------------------------------------------------------------------------------------------------------------------
Advanced Magnetics Inc Com 00753P103 3,808 909,235 Sh Defined 1 909,235
- ----------------------------------------------------------------------------------------------------------------------------
Aquila Biopharm Inc Com 03839F107 536 330,126 Sh Defined 1 330,126
- ----------------------------------------------------------------------------------------------------------------------------
Autoimmune Inc Com 052776101 3,232 1,360,800 Sh Defined 1 1,360,800
- ----------------------------------------------------------------------------------------------------------------------------
Avant Com 053491106 622 292,766 Sh Defined 1 292,766
Immunotherapeutics Inc
- ----------------------------------------------------------------------------------------------------------------------------
Biochem Pharma Inc Com 09058T108 1,921 102,430 Sh Defined 1 102,430
- ----------------------------------------------------------------------------------------------------------------------------
Cadus Pharaceutical Com 127639102 675 900,000 Sh Defined 1 900,000
Corp
- ----------------------------------------------------------------------------------------------------------------------------
Cambridge Com 132426107 2,539 2,672,500 Sh Defined 1 2,672,500
Nueroscience Inc
- ----------------------------------------------------------------------------------------------------------------------------
Clinichem Dev Inc Com 186906103 1,483 228,194 Sh Defined 1 228,194
- ----------------------------------------------------------------------------------------------------------------------------
Cortech Inc Com 22051J100 1,149 183,774 Sh Defined 1 183,774
- ----------------------------------------------------------------------------------------------------------------------------
Corvas Intl Inc Com 221005101 8,783 2,927,743 Sh Defined 1 2,927,743
- ----------------------------------------------------------------------------------------------------------------------------
Creative Biomolecules Com 225270107 988 272,500 Sh Defined 1 272,500
Inc.
- ----------------------------------------------------------------------------------------------------------------------------
</TABLE>
<PAGE>
Page 4 of 6
FORM 13F
<TABLE>
<CAPTION>
(SEC USE ONLY)
NAME OF REPORTING MANAGER: BVF INC.
- ----------------------------------------------------------------------------------------------------------------------------
COLUMN 1: COLUMN 2: COLUMN 3: COLUMN COLUMN 5: COLUMN 6: COLUMN 7: COLUMN 8:
NAME OF ISSUER TITLE OF CUSIP 4: INVESTMENT OTHER VOTING AUTHORITY
CLASS VALUE DISCRETION MANAGERS
(X$1000)
---------------------- ------------------------------
SHRS SH/ PUT/ SOLE SHARED NONE
PRN PRN CALL
- ----------------------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C> <C> <C> <C> <C> <C> <C>
- ----------------------------------------------------------------------------------------------------------------------------
Chiron Corporation Com 170040109 1,073 51,700 Sh Defined 1 51,700
- ----------------------------------------------------------------------------------------------------------------------------
Elan Pharmaceuticals Com 284131208 1,543 55,600 Sh Defined 1 55,600
- ----------------------------------------------------------------------------------------------------------------------------
Genome Therapeutics Com 372430108 5,338 1,779,285 Sh Defined 1 1,779,285
Corp
- ----------------------------------------------------------------------------------------------------------------------------
Glaxo Wellcome PLC Com 37733W105 283 5,000 Sh Defined 1 5,000
Sponsored ADR
- ----------------------------------------------------------------------------------------------------------------------------
Microcide Com 595018102 8,596 1,821,600 Sh Defined 1 1,821,600
Pharmaceuticals Inc
- ----------------------------------------------------------------------------------------------------------------------------
Molecular Biosystems Com 608513107 255 104,700 Sh Defined 1 104,700
Inc
- ----------------------------------------------------------------------------------------------------------------------------
Neurogen Corp Com 64124E106 26,164 1,789,006 Sh Defined 1 1,789,006
- ----------------------------------------------------------------------------------------------------------------------------
NPS Pharmaceuticals Com 62936P103 9,047 1,365,600 Sh Defined 1 1,365,600
Inc
- ----------------------------------------------------------------------------------------------------------------------------
OSI Pharmaceuticals Com 671040103 9,481 2,230,790 Sh Defined 1 2,230,790
Inc
- ----------------------------------------------------------------------------------------------------------------------------
Progenics Com 743187106 10,147 731,330 Sh Defined 1 731,330
Pharmaceuticals Inc
- ----------------------------------------------------------------------------------------------------------------------------
Protein Polymer Com 743697104 204 652,000 Sh Defined 1 652,000
Technologies
- ----------------------------------------------------------------------------------------------------------------------------
Repligen Corp Com 759916109 3,179 1,105,900 Sh Defined 1 1,105,900
- ----------------------------------------------------------------------------------------------------------------------------
Sibia Neurosciences Com 825732100 4,826 1,043,400 Sh Defined 1 1,043,400
Inc
- ----------------------------------------------------------------------------------------------------------------------------
</TABLE>
<PAGE>
Page 5 of 6
FORM 13F
<TABLE>
<CAPTION>
(SEC USE ONLY)
NAME OF REPORTING MANAGER: BVF INC.
- ----------------------------------------------------------------------------------------------------------------------------
COLUMN 1: COLUMN 2: COLUMN 3: COLUMN COLUMN 5: COLUMN 6: COLUMN 7: COLUMN 8:
NAME OF ISSUER TITLE OF CUSIP 4: INVESTMENT OTHER VOTING AUTHORITY
CLASS VALUE DISCRETION MANAGERS
(X$1000)
---------------------- ------------------------------
SHRS SH/ PUT/ SOLE SHARED NONE
PRN PRN CALL
- ----------------------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C> <C> <C> <C> <C> <C> <C>
- ----------------------------------------------------------------------------------------------------------------------------
Synaptic Com 87156R109 6,257 1,317,317 Sh Defined 1 1,317,317
Pharmaceutical Corp
- ----------------------------------------------------------------------------------------------------------------------------
Titan Pharmaceuticals Com 888314101 4,949 1,002,273 Sh Defined 1 1,002,273
Inc Del
- ----------------------------------------------------------------------------------------------------------------------------
Amgen Inc Com 031162100 852 14,000 Sh Put Defined 1 14,000
- ----------------------------------------------------------------------------------------------------------------------------
Biogen Inc. Com 090597105 3,537 55,000 Sh Put Defined 1 55,000
- ----------------------------------------------------------------------------------------------------------------------------
Centocor Inc Com 152342101 606 13,000 Sh Put Defined 1 13,000
- ----------------------------------------------------------------------------------------------------------------------------
Chiron Corp Com 170040109 2,075 100,000 Sh Put Defined 1 100,000
- ----------------------------------------------------------------------------------------------------------------------------
Glaxo Wellcome PLC Com 37733W105 6,116 108,000 Sh Put Defined 1 108,000
- ----------------------------------------------------------------------------------------------------------------------------
Johnson & Johnson Com 478160104 4,900 50,000 Sh Put Defined 1 50,000
- ----------------------------------------------------------------------------------------------------------------------------
Merck & Co Inc Com 589331107 7,363 100,000 Sh Put Defined 1 100,000
- ----------------------------------------------------------------------------------------------------------------------------
Smithkline Beecham PLC Com 832378301 1,916 29,000 Sh Put Defined 1 29,000
- ----------------------------------------------------------------------------------------------------------------------------
</TABLE>
<PAGE>
Page 6 of 6
FORM 13F
<TABLE>
<S><C>
(SEC USE ONLY)
NAME OF REPORTING MANAGER: BVF INC.
- ----------------------------------------------------------------------------------------------------------------------------
COLUMN 1: COLUMN 2: COLUMN 3: COLUMN COLUMN 5: COLUMN 6: COLUMN 7: COLUMN 8:
NAME OF ISSUER TITLE OF CUSIP 4: INVESTMENT OTHER VOTING AUTHORITY
CLASS VALUE DISCRETION MANAGERS
(X$1000)
---------------------- ------------------------------
SHRS SH/ PUT/ SOLE SHARED NONE
PRN PRN CALL
- ----------------------------------------------------------------------------------------------------------------------------
</TABLE>
