<PAGE>
AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON NOVEMBER 30, 1998
REGISTRATION NO. 333-51029
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- --------------------------------------------------------------------------------
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
---------------------
POST-EFFECTIVE AMENDMENT NO. 4
to
FORM S-1
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
--------------------
COLLATERAL THERAPEUTICS, INC.
(Exact name of Registrant as specified in its charter)
DELAWARE 8731 33-0661290
(State or other jurisdiction of (Primary Standard Industrial (I.R.S. Employer
incorporation or organization) Classification Code Number) Identification
Number)
--------------------
9360 TOWNE CENTRE DRIVE, SAN DIEGO, CALIFORNIA 92121 (619) 824-6500
(Address, including zip code, and telephone number, including area code, of
registrant's principal executive offices)
-------------------
JACK W. REICH, PH.D.
PRESIDENT AND CHIEF EXECUTIVE OFFICER
CHRISTOPHER J. REINHARD
CHIEF OPERATING AND FINANCIAL OFFICER
COLLATERAL THERAPEUTICS, INC.
9360 TOWNE CENTRE DRIVE
SAN DIEGO, CALIFORNIA 92121
(619) 824-6500
(Name, address, including zip code, and telephone number, including area
code, of agent for service)
------------------
WITH COPIES TO:
Faye H. Russell, Esq. Jeffrey E. Cohen, Esq.
Maria P. Sendra, Esq. Carol B. Stubblefield, Esq.
BROBECK, PHLEGER & HARRISON COUDERT BROTHERS
550 West "C" Street, Suite 1300 1114 Avenue of the Americas
San Diego, California 92101 New York, New York 10036
(619) 234-1966 (212) 626-4400
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If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering. / /
If this Form is a post-effective amendment filed pursuant to Rule
462(c) under the Securities Act, check the following box and list the Securities
Act registration statement number of the earlier effective registration
statement for the same offering. / /
If delivery of the prospectus is expected to be made pursuant to Rule
434, please check the following box. / /.
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<PAGE>
The Registrant hereby amends this Registration Statement on Form S-1
(Req. No. 333-51029) ("Registration Statement") to deregister and remove from
registration 330,000 shares of Collateral Therapeutics, Inc., Common Stock
remaining unsold at the conclusion of the Offering described in the
Registration Statement. The shares were the subject of an over-allotment
option granted to the underwriters which was not exercised.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the
registrant has duly caused this amendment to Registration Statement to be
signed on its behalf by the undersigned, thereunto duly authorized, in the
City of San Diego, California, on the 30th day of November, 1998.
COLLATERAL THERAPEUTICS, INC.
By: /S/ JACK W. REICH
--------------------------------
Jack W. Reich, Ph.D.
PRESIDENT AND CHIEF EXECUTIVE OFFICER
Pursuant to the requirements of the Securities Act of 1933, this
amendment to Registration Statement has been signed by the following persons
in the capacities and on the dates indicated.
<TABLE>
<CAPTION>
SIGNATURE TITLE DATE
--------- ----- ----
<S> <C> <C>
/s/ JACK W. REICH Director, President and Chief Executive November 30, 1998
- ---------------------------------- Officer (Principal Executive Officer)
(Jack W. Reich, Ph.D.)
*
- ---------------------------------- Director, Chief Operating and Chief November 30, 1998
(Christopher J. Reinhard) Financial Officer (Principal Financial and
Accounting Officer)
*
- ---------------------------------- Director and Secretary November 30, 1998
(Craig S. Andrews)
*
- ---------------------------------- Director, Vice President, Medical Director November 30, 1998
(Robert L. Engler)
*
- ---------------------------------- Director, Vice President, Research November 30, 1998
(H. Kirk Hammond)
*
- ---------------------------------- Director November 30, 1998
(Elise G. Klein)
*
- ---------------------------------- Director November 30, 1998
(David F. Hale)
*
- ---------------------------------- Director November 30, 1998
(David E. Robinson)
* /S/ JACK W. REICH
- ----------------------------------
(Jack W. Reich, Ph.D.)
ATTORNEY-IN-FACT
</TABLE>
