COLLATERAL THERAPEUTICS INC
S-8, EX-99.8, 2000-07-07
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                                                    EXHIBIT 99.8


                                                                   INITIAL GRANT


                          COLLATERAL THERAPEUTICS, INC.
                    NOTICE OF GRANT OF NON-EMPLOYEE DIRECTOR
                             AUTOMATIC STOCK OPTION

         Notice is hereby given of the following option grant (the "Option") to
purchase shares of the Common Stock of Collateral Therapeutics, Inc. (the
"Corporation"):

         OPTIONEE:__________________________

         GRANT DATE:________________________

         Exercise Price:  $______________ per share

         NUMBER OF OPTION SHARES: 15,000 shares

         EXPIRATION DATE:___________________

         TYPE OF OPTION: Non-Statutory Stock Option

         DATE EXERCISABLE:  Immediately Exercisable

         VESTING SCHEDULE: The Option Shares shall initially be unvested and
         subject to repurchase by the Corporation at the Exercise Price paid per
         share. Optionee shall acquire a vested interest in, and the
         Corporation's repurchase right shall accordingly lapse with respect to,
         the Option Shares in a series of three (3) successive equal annual
         installments upon the Optionee's completion of each year of service as
         a member of the Corporation's Board of Directors (the "Board") over the
         three (3)-year period measured from the Grant Date. In no event shall
         any additional Option Shares vest after Optionee's cessation of Board
         service.

         Optionee understands and agrees that the Option is granted subject to
and in accordance with the terms of the automatic option grant program under the
Collateral Therapeutics, Inc. 1998 Stock Incentive Plan (the "Plan"). Optionee
further agrees to be bound by the terms of the Plan and the terms of the Option
as set forth in the Automatic Stock Option Agreement attached hereto as EXHIBIT
A.

         Optionee hereby acknowledges receipt of a copy of the official
prospectus for the Plan in the form attached hereto as EXHIBIT B. A copy of the
Plan is available upon request made to the Corporate Secretary at the
Corporation's principal offices.

         REPURCHASE RIGHT. OPTIONEE HEREBY AGREES THAT ALL UNVESTED OPTION
SHARES ACQUIRED UPON THE EXERCISE OF THE OPTION SHALL BE SUBJECT TO A REPURCHASE
RIGHT EXERCISABLE BY THE CORPORATION AND ITS ASSIGNS. THE TERMS OF SUCH RIGHT
SHALL BE SPECIFIED IN A STOCK PURCHASE AGREEMENT, IN FORM AND SUBSTANCE
SATISFACTORY TO THE CORPORATION, EXECUTED BY OPTIONEE AT THE TIME OF THE OPTION
EXERCISE.

         NO IMPAIRMENT OF RIGHTS. Nothing in this Notice or the attached
Automatic Stock Option Agreement or in the Plan shall interfere with or
otherwise restrict in any way the rights of the Corporation and the
Corporation's stockholders to remove Optionee from the Board at any time in
accordance with the provisions of applicable law.


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         DEFINITIONS. All capitalized terms in this Notice shall have the
meaning assigned to them in this Notice or in the attached Automatic Stock
Option Agreement.


-----------------------------------, ------
Date



                                          COLLATERAL THERAPEUTICS, INC.


                                          By:
                                             -----------------------------------
                                          Title:
                                                --------------------------------


                                          --------------------------------------
                                          OPTIONEE

                         Address:
                                          --------------------------------------
                                          --------------------------------------


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