COLLATERAL THERAPEUTICS INC
S-8, EX-99.3, 2000-07-07
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                                                    EXHIBIT 99.3


                          COLLATERAL THERAPEUTICS, INC.
                             STOCK OPTION AGREEMENT


RECITALS

         A. The Board has adopted the Plan for the purpose of retaining the
services of selected Employees, non-employee members of the Board or of the
board of directors of any Parent or Subsidiary and consultants and other
independent advisors who provide services to the Corporation (or any Parent or
Subsidiary).

         B. Optionee is to render valuable services to the Corporation (or a
Parent or Subsidiary), and this Agreement is executed pursuant to, and is
intended to carry out the purposes of, the Plan in connection with the
Corporation's grant of an option to Optionee.

         C. All capitalized terms in this Agreement shall have the meaning
assigned to them in the attached Appendix.

         NOW, THEREFORE, it is hereby agreed as follows:

         1. GRANT OF OPTION. The Corporation hereby grants to Optionee, as of
the Grant Date, an option to purchase up to the number of Option Shares
specified in the Grant Notice. The Option Shares shall be purchasable from time
to time during the option term specified in Paragraph 2 at the Exercise Price.

         2. OPTION TERM. This option shall have a maximum term of ten (10) years
measured from the Grant Date and shall accordingly expire at the close of
business on the Expiration Date, unless sooner terminated in accordance with
Paragraph 5 or 6.

         3. LIMITED TRANSFERABILITY. This option shall be neither transferable
nor assignable by Optionee other than by will or by the laws of descent and
distribution following Optionee's death and may be exercised, during Optionee's
lifetime, only by Optionee. However, if this option is designated a
Non-Statutory Option in the Grant Notice, then this option may, in connection
with the Optionee's estate plan, be assigned in whole or in part during
Optionee's lifetime to one or more members of the Optionee's immediate family or
to a trust established for the exclusive benefit of the Optionee and/or one or
more such family members. The assigned portion shall be exercisable only by the
person or persons who acquire a proprietary interest in the option pursuant to
such assignment. The terms applicable to the assigned portion shall be the same
as those in effect for this option immediately prior to such assignment.

         4. DATES OF EXERCISE. This option shall become exercisable for the
Option Shares in one or more installments as specified in the Grant Notice. As
the option becomes exercisable for such installments, those installments shall
accumulate and the option shall remain exercisable for the accumulated
installments until the Expiration Date or sooner termination of the option term
under Paragraph 5 or 6.

         5. CESSATION OF SERVICE. The option term specified in Paragraph 2 shall
terminate (and this option shall cease to be outstanding) prior to the
Expiration Date should any of the following provisions become applicable:

                  (a) Should Optionee cease to remain in Service for any reason
         (other than death, Permanent Disability or Misconduct) while this
         option is outstanding, then the period for exercising this option shall
         be reduced to a three (3)-month period commencing with the date of such
         cessation of Service, but in no event shall this option be exercisable
         at any time after the Expiration Date.

                  (b) Should Optionee die while holding this option, then the
         personal representative of Optionee's estate or the person or persons
         to whom the option is transferred pursuant to Optionee's will or


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         in accordance with the laws of inheritance shall have the right to
         exercise this option. Such right shall lapse, and this option shall
         cease to be outstanding, upon the EARLIER of (i) the expiration of the
         twelve (12)-month period measured from the date of Optionee's death or
         (ii) the Expiration Date.

                  (c) Should Optionee cease Service by reason of Permanent
         Disability while this option is outstanding, then the period for
         exercising this option shall be reduced to a twelve (12)-month period
         commencing with the date of such cessation of Service, but no event
         shall this option be exercisable at any time after the Expiration Date.

                  (d) During the limited period of post-Service exercisability,
         this option may not be exercised in the aggregate for more than the
         number of vested Option Shares for which the option is exercisable at
         the time of Optionee's cessation of Service. Upon the expiration of
         such limited exercise period or (if earlier) upon the Expiration Date,
         this option shall terminate and cease to be outstanding for any
         otherwise exercisable Option Shares for which the option has not been
         exercised. However, this option shall, immediately upon Optionee's
         cessation of Service for any reason, terminate and cease to be
         outstanding with respect to any Option Shares for which this option is
         not otherwise at that time exercisable.

                  (e) Should Optionee's Service be terminated for Misconduct,
         then this option shall terminate immediately and cease to remain
         outstanding.

         6.       SPECIAL ACCELERATION OF OPTION.

                  (a) This option to the extent outstanding at the time of a
         Change in Control transaction but not otherwise fully exercisable,
         shall automatically accelerate so that this option shall, immediately
         prior to the effective date of such Change in Control, become
         exercisable for all of the Option Shares at the time subject to this
         option and may be exercised for any or all of those Option Shares as
         fully vested shares of Common Stock. However, this option shall not
         become exercisable on such an accelerated basis if and to the extent:
         (i) this option is, in connection with the Change in Control, to be
         assumed by the successor corporation (or parent thereof) or otherwise
         continued in full force and effect pursuant to the terms of the Change
         in Control transaction or (ii) this option is to be replaced with a
         cash incentive program of the successor corporation which preserves the
         spread existing at the time of the Change in Control on the Option
         Shares for which this option is not otherwise at that time exercisable
         (the excess of the Fair Market Value of those Option Shares over the
         aggregate Exercise Price payable for such shares) and provides for
         subsequent payout in accordance with the same option exercise/vesting
         schedule set forth in the Grant Notice.

                  (b) Immediately following the Change in Control, this option
         shall terminate and cease to be outstanding, except to the extent
         assumed by the successor corporation (or parent thereof) or otherwise
         continued in full force and effect pursuant to the terms of the Change
         in Control transaction.

                  (c) If this option is assumed in connection with a Change in
         Control (or otherwise continued in full force and effect), then this
         option shall be appropriately adjusted, immediately after such Change
         in Control, to apply to the number and class of securities or other
         property which would have been issuable to Optionee in consummation of
         such Change in Control had the option been exercised immediately prior
         to such Change in Control, and appropriate adjustments shall also be
         made to the Exercise Price, PROVIDED the aggregate Exercise Price shall
         remain the same.

                  (d) This option may also be subject to acceleration in
         accordance with the terms of any special Addendum attached to this
         Agreement.

                  (e) This Agreement shall not in any way affect the right of
         the Corporation to adjust, reclassify, reorganize or otherwise change
         its capital or business structure or to merge, consolidate, dissolve,
         liquidate or sell or transfer all or any part of its business or
         assets.


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         7.       ADJUSTMENT IN OPTION SHARES.

         Should any change be made to the Common Stock by reason of any stock
split, stock dividend, recapitalization, combination of shares, exchange of
shares or other change affecting the outstanding Common Stock as a class without
the Corporation's receipt of consideration, appropriate adjustments shall be
made to (i) the total number and/or class of securities subject to this option
and (ii) the Exercise Price in order to reflect such change and thereby preclude
a dilution or enlargement of benefits hereunder.

         8. STOCKHOLDER RIGHTS. The holder of this option shall not have any
stockholder rights with respect to the Option Shares until such person shall
have exercised the option, paid the Exercise Price and become a holder of record
of the purchased shares.

         9.       MANNER OF EXERCISING OPTION.

                  (a) In order to exercise this option with respect to all or
         any part of the Option Shares for which this option is at the time
         exercisable, Optionee (or any other person or persons exercising the
         option) must take the following actions:

                           (i) Execute and deliver to the Corporation a Notice
         of Exercise for the Option Shares for which the option is exercised.

                           (ii) Pay the aggregate Exercise Price for the
         purchased shares in one or more of the following forms:

                                    (A) cash or check made payable to the
                  Corporation; or

                                    (B) a promissory note payable to the
                  Corporation, but only to the extent authorized by the Plan
                  Administrator in accordance with Paragraph 13.

                                    (C) shares of Common Stock held by Optionee
                  (or any other person or persons exercising the option) for the
                  requisite period necessary to avoid a charge to the
                  Corporation's earnings for financial reporting purposes and
                  valued at Fair Market Value on the Exercise Date; or

                                    (D) through a special sale and remittance
                  procedure pursuant to which Optionee (or any other person or
                  persons exercising the option) shall concurrently provide
                  irrevocable instructions (I) to a Corporation-designated
                  brokerage firm to effect the immediate sale of the purchased
                  shares and remit to the Corporation, out of the sale proceeds
                  available on the settlement date, sufficient funds to cover
                  the aggregate Exercise Price payable for the purchased shares
                  plus all applicable Federal, state and local income and
                  employment taxes required to be withheld by the Corporation by
                  reason of such exercise and (II) to the Corporation to deliver
                  the certificates for the purchased shares directly to such
                  brokerage firm in order to complete the sale.

         Except to the extent the sale and remittance procedure is utilized in
connection with the option exercise, payment of the Exercise Price must
accompany the Notice of Exercise delivered to the Corporation in connection with
the option exercise.

                           (iii) Furnish to the Corporation appropriate
         documentation that the person or persons exercising the option (if
         other than Optionee) have the right to exercise this option.

                           (iv) Make appropriate arrangements with the
         Corporation (or Parent or Subsidiary employing or retaining Optionee)
         for the satisfaction of all Federal, state and local income and
         employment tax withholding requirements applicable to the option
         exercise.


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                  (b) As soon as practical after the Exercise Date, the
Corporation shall issue to or on behalf of Optionee (or any other person or
persons exercising this option) a certificate for the purchased Option Shares,
with the appropriate legends affixed thereto.

                  (c) In no event may this option be exercised for any
fractional shares.

         10.      COMPLIANCE WITH LAWS AND REGULATIONS.

                  (a) The exercise of this option and the issuance of the Option
         Shares upon such exercise shall be subject to compliance by the
         Corporation and Optionee with all applicable requirements of law
         relating thereto and with all applicable regulations of any stock
         exchange (or the Nasdaq National Market, if applicable) on which the
         Common Stock may be listed for trading at the time of such exercise and
         issuance.

                  (b) The inability of the Corporation to obtain approval from
         any regulatory body having authority deemed by the Corporation to be
         necessary to the lawful issuance and sale of any Common Stock pursuant
         to this option shall relieve the Corporation of any liability with
         respect to the non-issuance or sale of the Common Stock as to which
         such approval shall not have been obtained. The Corporation, however,
         shall use its best efforts to obtain all such approvals.

         11. SUCCESSORS AND ASSIGNS. Except to the extent otherwise provided in
Paragraphs 3 and 6, the provisions of this Agreement shall inure to the benefit
of, and be binding upon, the Corporation and its successors and assigns and
Optionee, Optionee's assigns and the legal representatives, heirs and legatees
of Optionee's estate.

         12. NOTICES. Any notice required to be given or delivered to the
Corporation under the terms of this Agreement shall be in writing and addressed
to the Corporation at its principal corporate offices. Any notice required to be
given or delivered to Optionee shall be in writing and addressed to Optionee at
the address indicated below Optionee's signature line on the Grant Notice. All
notices shall be deemed effective upon personal delivery or upon deposit in the
U.S. mail, postage prepaid and properly addressed to the party to be notified.

         13. FINANCING. The Plan Administrator may, in its absolute discretion
and without any obligation to do so, permit Optionee to pay the Exercise Price
for the purchased Option Shares by delivering a full-recourse promissory note
payable to the Corporation. The terms of any such promissory note (including the
interest rate, the requirements for collateral and the terms of repayment) shall
be established by the Plan Administrator in its sole discretion.

         14. CONSTRUCTION. This Agreement and the option evidenced hereby are
made and granted pursuant to the Plan and are in all respects limited by and
subject to the terms of the Plan. All decisions of the Plan Administrator with
respect to any question or issue arising under the Plan or this Agreement shall
be conclusive and binding on all persons having an interest in this option.

         15. GOVERNING LAW. The interpretation, performance and enforcement of
this Agreement shall be governed by the laws of the State of California without
resort to that State's conflict-of-laws rules.

         16. EXCESS SHARES. If the Option Shares covered by this Agreement
exceed, as of the Grant Date, the number of shares of Common Stock which may
without stockholder approval be issued under the Plan, then this option shall be
void with respect to those excess shares, unless stockholder approval of an
amendment sufficiently increasing the number of shares of Common Stock issuable
under the Plan is obtained in accordance with the provisions of the Plan.

         17. ADDITIONAL TERMS APPLICABLE TO AN INCENTIVE OPTION. In the event
this option is designated an Incentive Option in the Grant Notice, the following
terms and conditions shall also apply to the grant:


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                  (a) This option shall cease to qualify for favorable tax
         treatment as an Incentive Option if (and to the extent) this option is
         exercised for one or more Option Shares: (A) more than three (3) months
         after the date Optionee ceases to be an Employee for any reason other
         than death or Permanent Disability or (B) more than twelve (12) months
         after the date Optionee ceases to be an Employee by reason of Permanent
         Disability.

                  (b) No installment under this option shall qualify for
         favorable tax treatment as an Incentive Option if (and to the extent)
         the aggregate Fair Market Value (determined at the Grant Date) of the
         Common Stock for which such installment first becomes exercisable
         hereunder would, when added to the aggregate value (determined as of
         the respective date or dates of grant) of the Common Stock or other
         securities for which this option or any other Incentive Options granted
         to Optionee prior to the Grant Date (whether under the Plan or any
         other option plan of the Corporation or any Parent or Subsidiary) first
         become exercisable during the same calendar year, exceed One Hundred
         Thousand Dollars ($100,000) in the aggregate. Should such One Hundred
         Thousand Dollar ($100,000) limitation be exceeded in any calendar year,
         this option shall nevertheless become exercisable for the excess shares
         in such calendar year as a Non-Statutory Option.

                  (c) Should the exercisability of this option be accelerated
         upon a Change in Control transaction, then this option shall qualify
         for favorable tax treatment as an Incentive Option only to the extent
         the aggregate Fair Market Value (determined at the Grant Date) of the
         Common Stock for which this option first becomes exercisable in the
         calendar year in which the Change in Control occurs does not, when
         added to the aggregate value (determined as of the respective date or
         dates of grant) of the Common Stock or other securities for which this
         option or one or more other Incentive Options granted to Optionee prior
         to the Grant Date (whether under the Plan or any other option plan of
         the Corporation or any Parent or Subsidiary) first become exercisable
         during the same calendar year, exceed One Hundred Thousand Dollars
         ($100,000) in the aggregate. Should the applicable One Hundred Thousand
         Dollar ($100,000) limitation be exceeded in the calendar year of such
         Change in Control, the option may nevertheless be exercised for the
         excess shares in such calendar year as a Non-Statutory Option.

                  (d) Should Optionee hold, in addition to this option, one or
         more other options to purchase Common Stock which become exercisable
         for the first time in the same calendar year as this option, then the
         foregoing limitations on the exercisability of such options as
         Incentive Options shall be applied on the basis of the order in which
         such options are granted.


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                                    EXHIBIT I
                               NOTICE OF EXERCISE


         I hereby notify Collateral Therapeutics, Inc. (the "Corporation") that
I elect to purchase ________ shares of the Corporation's Common Stock (the
"Purchased Shares") at the option exercise price of $ ____________ per share
(the "Exercise Price") pursuant to that certain option (the "Option") granted to
me under the Corporation's 1998 Stock Incentive Plan on ___________, ____.

         Concurrently with the delivery of this Exercise Notice to the
Corporation, I shall hereby pay to the Corporation the Exercise Price for the
Purchased Shares in accordance with the provisions of my agreement with the
Corporation (or other documents) evidencing the Option and shall deliver
whatever additional documents may be required by such agreement as a condition
for exercise. Alternatively, I may utilize the special broker-dealer sale and
remittance procedure specified in my agreement to effect payment of the Exercise
Price.


   -----------------------, -----                 ------------------------------
   Date                                           Optionee
                                       Address:
                                                  ------------------------------
                                                  ------------------------------

   Print name in exact manner                     ------------------------------
   it is to appear on the
   stock certificate:

   Address to which certificate                   ------------------------------
   is to be sent, if different
   from address above:

   Social Security Number:
                                                  ------------------------------
   Employee Number:
                                                  ------------------------------


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                                    APPENDIX

         The following definitions shall be in effect under the Agreement:

         A. AGREEMENT shall mean this Stock Option Agreement.

         B. BOARD shall mean the Corporation's Board of Directors.

         C. CHANGE IN CONTROL shall mean a change in ownership or control of the
Corporation effected through any of the following transactions:

                  (i) a merger or consolidation in which securities possessing
         more than fifty percent (50%) of the total combined voting power of the
         Corporation's outstanding securities are transferred to a person or
         persons different from the persons holding those securities immediately
         prior to such transaction, or

                  (ii) the sale, transfer or other disposition of all or
         substantially all of the Corporation's assets in complete liquidation
         or dissolution of the Corporation, or

                  (iii) the acquisition, directly or indirectly, by any person
         or related group of persons (other than the Corporation or a person
         that directly or indirectly controls, is controlled by, or is under
         common control with, the Corporation) of beneficial ownership (within
         the meaning of Rule 13d-3 of the 1934 Act) of securities possessing
         more than fifty percent (50%) of the total combined voting power of the
         Corporation's outstanding securities pursuant to a tender or exchange
         offer made directly to the Corporation's stockholders, or

                  (iv) a change in the composition of the Board over a period of
         thirty-six (36) consecutive months or less such that a majority of the
         Board members ceases, by reason of one or more contested elections for
         Board membership, to be comprised of individuals who either (A) have
         been Board members continuously since the beginning of such period or
         (B) have been elected or nominated for election as Board members during
         such period by at least a majority of the Board members described in
         clause (A) who were still in office at the time the Board approved such
         election or nomination.

         D. CODE shall mean the Internal Revenue Code of 1986, as amended.

         E. COMMON STOCK shall mean shares of the Corporation's common stock.

         F. CORPORATION shall mean Collateral Therapeutics, Inc., a Delaware
corporation.

         G. EMPLOYEE shall mean an individual who is in the employ of the
Corporation (or any Parent or Subsidiary), subject to the control and direction
of the employer entity as to both the work to be performed and the manner and
method of performance.

         H. EXERCISE DATE shall mean the date on which the option shall have
been exercised in accordance with Paragraph 9 of the Agreement.

         I. EXERCISE PRICE shall mean the exercise price per Option Share as
specified in the Grant Notice.

         J. EXPIRATION DATE shall mean the date on which the option expires as
specified in the Grant Notice.

         K. FAIR MARKET VALUE per share of Common Stock on any relevant date
shall be determined in accordance with the following provisions:


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                  (i) If the Common Stock is at the time traded on the Nasdaq
         National Market, then the Fair Market Value shall be deemed equal to
         the closing selling price per share of Common Stock on the date in
         question, as the price is reported by the National Association of
         Securities Dealers on the Nasdaq National Market. If there is no
         closing selling price for the Common Stock on the date in question,
         then the Fair Market Value shall be the closing selling price on the
         last preceding date for which such quotation exists.

                  (ii) If the Common Stock is at the time listed on any Stock
         Exchange, then the Fair Market Value shall be deemed equal to the
         closing selling price per share of Common Stock on the date in question
         on the Stock Exchange determined by the Plan Administrator to be the
         primary market for the Common Stock, as such price is officially quoted
         in the composite tape of transactions on such exchange. If there is no
         closing selling price for the Common Stock on the date in question,
         then the Fair Market Value shall be the closing selling price on the
         last preceding date for which such quotation exists.

         L. GRANT DATE shall mean the date of grant of the option as specified
in the Grant Notice.

         M. GRANT NOTICE shall mean the Notice of Grant of Stock Option
accompanying the Agreement, pursuant to which Optionee has been informed of the
basic terms of the option evidenced hereby.

         N. INCENTIVE OPTION shall mean an option which satisfies the
requirements of Code Section 422.

         O. MISCONDUCT shall mean the commission of any act of fraud,
embezzlement or dishonesty by Optionee, any unauthorized use or disclosure by
Optionee of confidential information or trade secrets of the Corporation (or any
Parent or Subsidiary), or any other intentional misconduct by Optionee adversely
affecting the business or affairs of the Corporation (or any Parent or
Subsidiary) in a material manner. The foregoing definition shall not be deemed
to be inclusive of all the acts or omissions which the Corporation (or any
Parent or Subsidiary) may consider as grounds for the dismissal or discharge of
Optionee or any other individual in the Service of the Corporation (or any
Parent or Subsidiary).

         P. 1934 ACT shall mean the Securities Exchange Act of 1934, as amended.

         Q. NON-STATUTORY OPTION shall mean an option not intended to satisfy
the requirements of Code Section 422.

         R. NOTICE OF EXERCISE shall mean the notice of exercise in the form
attached hereto as Exhibit I.

         S. OPTION SHARES shall mean the number of shares of Common Stock
subject to the option as specified in the Grant Notice.

         T OPTIONEE shall mean the person to whom the option is granted as
specified in the Grant Notice.

         U. PARENT shall mean any corporation (other than the Corporation) in an
unbroken chain of corporations ending with the Corporation, provided each
corporation in the unbroken chain (other than the Corporation) owns, at the time
of the determination, stock possessing fifty percent (50%) or more of the total
combined voting power of all classes of stock in one of the other corporations
in such chain.

         V. PERMANENT DISABILITY shall mean the inability of Optionee to engage
in any substantial gainful activity by reason of any medically determinable
physical or mental impairment which is expected to result in death or has lasted
or can be expected to last for a continuous period of twelve (12) months or
more.

         W. PLAN shall mean the Corporation's 1998 Stock Incentive Plan.

         X. PLAN ADMINISTRATOR shall mean either the Board or a committee of the
Board acting in its capacity as administrator of the Plan.


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         Y. SERVICE shall mean the Optionee's performance of services for the
Corporation (or any Parent or Subsidiary) in the capacity of an Employee, a
non-employee member of the board of directors or a consultant or independent
advisor.

         Z. STOCK EXCHANGE shall mean the American Stock Exchange or the New
York Stock Exchange.

         AA. SUBSIDIARY shall mean any corporation (other than the Corporation)
in an unbroken chain of corporations beginning with the Corporation, provided
each corporation (other than the last corporation) in the unbroken chain owns,
at the time of the determination, stock possessing fifty percent (50%) or more
of the total combined voting power of all classes of stock in one of the other
corporations in such chain.


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