Report of Independent Accountants
To the Board of Directors and Shareholders of
Alliance Select Investor Series, Inc. - Premier Portfolio
In planning and performing our audit of the financial statements
of Alliance Select Investor Series, Inc. - Premier Portfolio (the "Fund")
for the year ended October 31, 2000, we considered its internal control,
including control activities for safeguarding securities, in order
to determine our auditing procedures for the purpose of expressinG
our opinion on the financial statements and to comply with the requirements
of Form N-SAR, not to provide assurance on internal control.
The management of the Fund is responsible for establishing and maintaining
internal control. In fulfilling this responsibility, estimates and
judgements by management are required to assess the expected benefits and
related costs of controls. Generally, controls that are relevant to
an audit pertain to the entity's objective of preparing financial statements
for external purposes that are fairly presented in conformity with generally
accepted accounting principles. Those controls include the safeguarding of
assets against unauthorized acquisition, use or disposition.
Because of inherent limitations in internal control, error or fraud may occur
and not be detected. Also, projection of any evaluation of internal control
to future periods is subject to the risk that it may become inadequate because
of changes in conditions or that the effectiveness of the design and operation
may deteriorate.
Our consideration of internal control would not necessarily disclose all
matters in internal control that might be material weaknesses under standards
established by the American Institute of Certified Public Accountants.
A material weakness is a condition in which the design or operation of one
or more of the internal control components does not reduce to a relatively low
level the risk that misstatements caused by error or fraud in amounts that
would
be material in relation to the financial statements being audited may
occur and not
be detected within a timely period by employees in the normal course
of performing
their assigned functions. However, we noted no matters involving
internal control
and its operation, including controls for safeguarding securities, that
we consider to be material weaknesses as defined above as of October 31, 2000.
This report is intended solely for the information and use of management and
the Board of Directors of the Fund and the Securities and Exchange Commission,
and is not intended to be and should not be used by anyone other than these
specified parties.
PricewaterhouseCoopers LLP
New York, NY 10036
December 18, 2000
