CELL PATHWAYS HOLDINGS INC
DEFA14A, 1998-10-15
PHARMACEUTICAL PREPARATIONS
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                                                Supplemental Proxy Materials
                                                filed pursuant to Rule 14a-2
                                                under the Securities Exchange 
                                                Act of 1934

[TSENG LETTERHEAD]                              October 15, 1998



Dear Tseng Labs, Inc. Stockholder:

You are cordially invited to attend a 30 minute luncheon presentation by the
Cell Pathways, Inc. management team with respect to the Cell Pathways/Tseng
transaction and the business of Cell Pathways at the following locations:

City                   Date and Time      Location                Call
- ----                   --------------     ---------               -----

San Francisco          Wednesday,         Salomon Smith Barney    Helen Kim
                       October 21         39th fl.                415-955-1605  
                       12:30 p.m.         555 California Street

Chicago                Friday,            Salomon Smith Barney    Kathy Boyer
                       October 23         87th fl.                312-419-3627
                       12:15 p.m.         Sears Tower   

New York City          Tuesday,           The Omni Berkshire      Stacey Alosa
                       October 27         Hotel                   212-723-7297
                       12:00 p.m.         Carnegie Room
                                          21 East 52nd St.

Philadelphia           Thursday,          The Pyramid Club        Bill Freeman
                       October 29         52nd fl.                215-854-6034
                       12:00 p.m.         Mellon Bank Center    
                                          1735 Market St.


You should have already received proxy materials with respect to the November 3
special meeting of stockholders of Tseng Labs, Inc. to consider the proposed
transaction with Cell Pathways.  Additional proxy materials/prospectuses will
be available at these presentations.  Representatives from Salomon Smith
Barney, BancBoston Robertson Stephens, and Cell Pathways will be available to
answer any questions.  Please call the appropriate person listed above to
reserve space.

As described in the proxy materials previously sent to you, Cell Pathways is a
pharmaceutical company focused on the development and commercialization of
products to prevent and treat cancer.  The proposed transaction is intended to
provide substantial funding for the programs of Cell Pathways.  In the
transaction, the new Cell Pathways will issue its common stock to the
stockholders of both Tseng Labs and Cell Pathways in exchange for all the stock
they now own in their respective companies, with the exchange ratio as
specified in the Reogranization Agreement.  Stockholder meetings to approve the
transaction will be held on November 2 (Cell Pathways) and November 3 (Tseng). 
The common stock of the new Cell Pathways is expected to commence trading on
the NASDAQ National Market assuming approval of the transaction at such
stockholders' meetings.

We look forward to your attendance at any of the presentations listed above.

Sincerely,                                 Sincerely,

/s/ Robert J. Towarnicki                   /s/ John J. Gibbons
- ------------------------                   --------------------
Robert J. Towarnicki                       John J. Gibbons
Chief Executive Officer                    Chairman of the Board of Directors
Cell Pathways, Inc.                        Tseng Labs, Inc.


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