CELL PATHWAYS HOLDINGS INC
DEF 14A, 1999-04-30
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1
                                  SCHEDULE 14A
                                 (RULE 14a-101)
 
                    INFORMATION REQUIRED IN PROXY STATEMENT
 
                            SCHEDULE 14A INFORMATION
          PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES
                     EXCHANGE ACT OF 1934 (AMENDMENT NO.  )
 
     Filed by the Registrant [ ]

     Filed by a Party other than the Registrant [ ]
 
     Check the appropriate box:
 
     [ ] Preliminary Proxy Statement        [ ] Confidential, for Use of the
                                                Commission Only (as permitted by
                                                Rule 14a-6(e)(2))
     [X] Definitive Proxy Statement
 
     [ ] Definitive Additional Materials
 
     [ ] Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12

                           CELL PATHWAYS, INC.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified in Its Charter)

 
- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement if other than the Registrant)
 
Payment of Filing Fee (Check the appropriate box):
 
     [X] No fee required.
 
     [ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and
         0-11.
 
     (1) Title of each class of securities to which transaction applies:
 
- --------------------------------------------------------------------------------
 
     (2) Aggregate number of securities to which transaction applies:
 
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     (3) Per unit price or other underlying value of transaction computed
         pursuant to Exchange Act Rule 0-11 (Set forth the amount on which the
         filing fee is calculated and state how it was determined):
 
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     (4) Proposed maximum aggregate value of transaction:
 
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     (5) Total fee paid:
 
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     [ ] Fee paid previously with preliminary materials.
 
     [ ] Check box if any part of the fee is offset as provided by Exchange Act
         Rule 0-11(a)(2) and identify the filing for which the offsetting fee
         was paid previously. Identify the previous filing by registration
         statement number, or the form or schedule and the date of its filing.
 
     (1) Amount previously paid:
 
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     (2) Form, schedule or registration statement no.:
 
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     (3) Filing party:
 
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<PAGE>   2
 
                              CELL PATHWAYS, INC.
                              702 ELECTRONIC DRIVE
                          HORSHAM, PENNSYLVANIA 19044
 
                                                                  April 30, 1999
 
Dear Stockholder:
 
     You are cordially invited to attend the 1999 Annual Meeting of Stockholders
of Cell Pathways, Inc. which will be held on June 22, 1999 at 10:00 a.m. at the
Rittenhouse Hotel, 210 West Rittenhouse Square, Philadelphia, Pennsylvania.
 
     At this year's meeting, you will be asked to elect three directors to serve
terms of three years each.
 
     The Notice of Annual Meeting of Stockholders, Proxy Statement, form of
proxy and 1998 Annual Report to Stockholders are included with this letter.
 
     Upon adjournment of the meeting, the directors and officers of the Company
will be available to confer informally with stockholders.
 
     We hope that many of you will be with us. Whether or not you plan to
attend, please sign, date and return your proxy promptly in the enclosed
envelope.
 
                                          Sincerely yours,
                                          /s/ Robert J. Towarnicki
                                          Robert J. Towarnicki
                                          President and Chief Executive Officer
<PAGE>   3
 
                              CELL PATHWAYS, INC.
                              702 ELECTRONIC DRIVE
                          HORSHAM, PENNSYLVANIA 19044
 
                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                            TO BE HELD JUNE 22, 1999
 
To the Stockholders of Cell Pathways, Inc.:
 
     The 1999 Annual Meeting of Stockholders of Cell Pathways, Inc., a Delaware
corporation, will be held at the Rittenhouse Hotel, 210 West Rittenhouse Square,
Philadelphia, Pennsylvania on Tuesday, the 22nd day of June, 1999 at 10:00 a.m.
for the following purposes:
 
          (1) to elect three directors for terms of three years each;
 
          (2) to consider and act upon such other business as may properly come
              before the meeting.
 
     Stockholders of record at the close of business on April 23, 1999 will be
entitled to vote at the meeting. The date of mailing this Notice of Meeting and
Proxy Statement is on or about April 30, 1999.
 
                                          By order of the Board of Directors
 
                                          Richard H. Troy
                                          Secretary
 
Horsham, Pennsylvania
April 30, 1999
 
                                   IMPORTANT
 
WHETHER OR NOT YOU PLAN TO ATTEND THE MEETING IN PERSON, PLEASE SIGN AND DATE
THE ENCLOSED PROXY AND RETURN IT PROMPTLY IN THE ENCLOSED ENVELOPE.
 
THE COMPANY'S 1998 ANNUAL REPORT ACCOMPANIES THE PROXY STATEMENT.
<PAGE>   4
 
                              CELL PATHWAYS, INC.
                              702 ELECTRONIC DRIVE
                          HORSHAM, PENNSYLVANIA 19044
 
                                PROXY STATEMENT
 
SOLICITATION OF PROXY
 
     The enclosed proxy is solicited by the Board of Directors (the "Board") of
Cell Pathways, Inc. (the "Company") for use at the 1999 Annual Meeting of
Stockholders to be held on June 22, 1999 at the Rittenhouse Hotel, 210 West
Rittenhouse Square, Philadelphia, PA. at 10:00 a.m. including any adjournment or
rescheduling thereof (the "Annual Meeting"). A copy of the Notice of Annual
Meeting accompanies this Proxy Statement. It is anticipated that the mailing of
this Proxy Statement will commence on or about April 30, 1999.
 
     Whether or not you plan to attend the Annual Meeting, the Board
respectfully requests the privilege of voting on your behalf and urges you to
sign, date and return the enclosed proxy. By doing so you will, unless such
proxy is subsequently revoked by you, authorize the persons named therein, or
any of them, to act on your behalf at the Annual Meeting.
 
     Any stockholder who submits a proxy may revoke it by giving a written
notice of revocation to the Secretary, or by submitting a duly executed proxy
bearing a later date, at or before the Annual Meeting and before the proxy is
voted.
 
ACTION TO BE TAKEN AT THE ANNUAL MEETING
 
     Three directors will be elected to serve for terms of three years each and
until their respective successors are elected and qualified.
 
SHARES OUTSTANDING; VOTING
 
     Shares represented by valid proxies in the accompanying form, and not
revoked prior to exercise, will be voted in accordance with the instructions
indicated thereon. If no contrary instruction is indicated, shares represented
by such proxies will be voted FOR the election of the individuals herein
nominated for directors. The Company does not know of any other matters that
will be presented at the meeting. However, if any other matters properly come
before the meeting, or any of its adjournments, the person or persons voting the
proxies will vote them in accordance with their best judgment on such matters.
If a director nominee is unable to serve or for good cause will not serve, the
proxies will be voted for such substitute nominee as the Board may propose; the
Company has no reason to believe that this contingency may arise in connection
with this Annual Meeting.
 
     Only holders of shares of the Common Stock of the Company (the "Common
Stock") at the close of business on April 23, 1999, the record date for the
Annual Meeting, will be entitled to vote at the Annual Meeting. On April 23,
1999, the outstanding stock of the Company entitled to vote consisted of
24,315,013 shares of Common Stock, with each such share entitled to one vote.
Appearance at the Annual Meeting in person or by proxy of the holders of Common
Stock entitled to cast 12,157,507 votes is required for a quorum. Shares
represented by abstentions or broker non-votes will be counted as shares that
are present entitled to vote for purposes of determining the presence of a
quorum. A broker "non-vote" occurs when a registered broker holding a customer's
shares in the name of the broker has not received voting instructions on the
matter from the customer, is barred by applicable rules from exercising
discretionary voting authority in the matter, and so indicates on the proxy.
 
     Directors will be elected by a plurality of the affirmative votes cast (in
person or by proxy). This means that the director nominee with the most
affirmative votes for a particular slot is elected for that slot. In an
uncontested election for directors, the plurality requirement is not a factor.
Abstentions and broker non-votes will not negatively affect the election of
candidates receiving the plurality of votes.
<PAGE>   5
 
     In matters other than election of directors, except as otherwise provided
by law or by the Certificate of Incorporation or Bylaws of the Company with
respect to particular types of matters, action of stockholders is taken by a
majority of the votes cast, excluding abstentions, at any meeting at which there
is present a quorum of shares entitled to vote. In such matters, abstentions and
broker non-votes will be treated as not voted and will not be counted as votes
for or against such proposal.
 
     During 1998, Cell Pathways, Inc., a privately held Delaware corporation,
created a Delaware subsidiary in order to acquire both Tseng Labs, Inc
("Tseng"). and itself in a transaction pursuant to which the subsidiary became
the parent and publicly traded company and was renamed Cell Pathways, Inc.
References to the "Company" or "Cell Pathways" in this Proxy Statement are
intended to include, in appropriate contexts, both the former Cell Pathways,
Inc., the privately held company which is now a subsidiary, and the new publicly
held parent company, Cell Pathways, Inc., which hereby solicits your proxy for
use in connection with the Annual Meeting.
 
     Your vote is important. Accordingly, you are asked to complete, sign and
return the accompanying proxy card whether or not you plan to attend the
meeting. If you plan to attend the meeting to vote in person and your shares are
registered with the Company's transfer agent in the name of a broker or bank,
you must secure a proxy card from the broker or bank assigning voting rights to
you for your shares.
 
                                        2
<PAGE>   6
 
                             ELECTION OF DIRECTORS
 
NOMINEES FOR ELECTION AS DIRECTORS
 
     The Board of the Company is divided into three classes, Class I, Class II
and Class III. Each class consists as nearly as may be possible of one-third of
the total number of directors, and one class is elected each year for a
three-year term. The terms of the Class I directors expire at the 1999 Annual
Meeting and their successors are to be elected at the 1999 Annual Meeting for
three year terms expiring at the annual meeting of 2002. The terms of the Class
II and Class III directors expire at the annual meetings of 2000 and 2001,
respectively.
 
     The nominees for election as Class I directors of the Company are Thomas M.
Gibson, Roger J. Quy and Randall M. Toig, M.D.
 
     The following information is provided for the three nominees proposed to be
elected as Class I directors, and also for the continuing Class II and Class III
directors. All of such nominees and Class II and Class III directors were
elected by the Company's stockholders, except for Messrs. Gibbons and Weiner who
were elected by the Company's Board as Class II directors for terms expiring at
the annual meeting of 2000 in accordance with the terms of the agreement and
plan of reorganization dated June 23, 1998 pursuant to which the Company
acquired Tseng.
 
<TABLE>
<CAPTION>
                                                DIRECTOR
                 NAME                    AGE     SINCE               POSITION WITH THE COMPANY
                 ----                    ---    --------             -------------------------
<S>                                      <C>    <C>         <C>
  NOMINEES FOR CLASS I DIRECTORS:
Thomas M. Gibson(1)....................  72       1996      Director
Roger J. Quy(2)........................  48       1992      Director
Randall M. Toig, M.D...................  48       1994      Director
  CLASS II DIRECTORS:
William A. Boeger(1, 2)................  49       1992      Chairman of the Board of Directors
John J. Gibbons(1).....................  60       1998      Director
Peter G. Schiff(2).....................  47       1992      Director
Louis M. Weiner........................  47       1998      Director
  CLASS III DIRECTORS:
Judith A. Hemberger....................  51       1998      Director
Bruce R. Ross(2).......................  58       1998      Director
Robert J. Towarnicki...................  47       1996      Director; President and Chief Executive
                                                            Officer of the Company
Richard H. Troy........................  61       1992      Director; Senior Vice President --
                                                            Corporate Development, General
                                                            Counsel and Secretary of the Company
</TABLE>
 
- ---------------
(1) Member of the Audit Committee
 
(2) Member of the Compensation and Stock Option Committee
 
RECOMMENDATION OF THE BOARD OF DIRECTORS
 
     The Board unanimously recommends a vote FOR election of the nominees for
Class I directors.
 
THE BOARD OF DIRECTORS
 
     William A. Boeger, 49, has served as Chairman of the Board of the Company
since September 1996 and as a director since December 1992. He is President and
Chief Executive Officer of Calypte Biomedical Corporation, and has served as
Chairman of the Board of Calypte since 1993. Since 1986 he has been Managing
General Partner of Quest Ventures II, a venture capital company that he founded.
 
                                        3
<PAGE>   7
 
From 1981 to 1986, Mr. Boeger was employed by Continental Capital Ventures, a
publicly-traded venture capital fund, where he attained the position of General
Partner. Mr. Boeger is also a director of Iridex Corporation.
 
     John J. Gibbons, 60, has served as a director since November 1998. He was
the President, Chief Executive Officer and Chairman of Tseng Labs, Inc. from
November 1997 until the acquisition of Tseng by the Company in November 1998.
From December 1996 until November 1997, Mr. Gibbons was Executive Vice President
and Chief Operating Officer of Tseng. From January 1996 to November 1996, Mr.
Gibbons served as a consultant to Tseng. Mr. Gibbons served as Tseng's Chief
Financial Officer from January 1989 to May 1991, and as a Vice-Chairman from May
1991 to December 1995. Mr. Gibbons was a director of Tseng from 1983 through
November 1998. Tseng was a supplier of video graphic controller chips to the
computer industry
 
     Thomas M. Gibson, 72, has served as a director of the Company since August
1996. From 1947 to 1992 he served with Gibson Electric Company, Inc., of which
he was Chief Executive Officer at the time of the sale of that company. He
served as President of Jupiter Electric Company, Inc. until 1996 and has served
as President of Integrated Technologies Development Corporation since 1995. In
the early 1980s he co-founded Gibson Information Systems, a data service bureau
which he sold in 1986. He is President of Thomas Gibson, Inc., Management
Consultants.
 
     Judith A. Hemberger, Ph.D., 51 has served as a director of the Company
since June 1998. She is Senior Vice President, Business and Planning, Avax
Technologies, Inc. Since 1997, she has served as Vice-Chair, Strategic Planning
and Regulatory Affairs, Mayo Foundation for Medical Research and Education. From
1979 to 1997, she served with Marion Merrell Dow Inc., most recently as Senior
Vice President, Global Regulatory Affairs (1995-1997), and Vice President,
Global Medical Affairs and Commercial Development (1994-1995). She is a member
of the Board of Directors of NexStar Pharmaceutical Company, the International
Board of Directors of Pharmaceutical Research Associates, and of the Dean's
Advisory Board, School of Pharmacy, University of Missouri at Kansas City. Since
1985, she has been Adjunct Associate Professor, Division of Pharmacology,
University of Missouri at Kansas City School of Pharmacy.
 
     Roger J. Quy, Ph.D., 48, has served as a director of the Company since
December 1992. He has been a General Partner of Technology Partners, a venture
capital firm, since 1990 and has been responsible for health care investments at
Technology Partners since 1989. From 1982 to 1989, Dr. Quy held various
management positions with the Hewlett-Packard Company.
 
     Bruce R. Ross, 58, has served as a director of the Company since January
1998. From 1994 to 1997, he served as Chief Executive Officer of The National
Comprehensive Cancer Network, an association of fifteen U.S. cancer centers.
From 1976 to 1994, he held various positions with Bristol-Myers Squibb Company,
including as Senior Vice President, Policy, Planning and Development of the U.S.
Pharmaceutical Group from 1993 to 1994 and as President of the U.S.
Pharmaceutical Group from 1990 to 1992. He is a director of Sugen, Inc. and Idec
Pharmaceuticals, Inc. and is a consultant at Cancer Rx, Inc.
 
     Peter G. Schiff, 47, has served as a director of the Company since December
1992. He is the President and founder of Northwood Ventures LLC, a firm
specializing in venture capital and leveraged buyouts, President of Northwood
Capital Partners LLC, and Managing General Partner of Rabbit Hollow Partners.
Prior to founding Northwood Ventures LLC in 1983, Mr. Schiff worked at E.M.
Warburg, Pincus & Co., Inc. from 1980 to 1983, and at Chemical Bank from 1976 to
1980.
 
     Randall M. Toig, M.D., 48, has served as a director of the Company since
November 1994. He has been in private medical practice at Prentise Women's
Hospital in Chicago, Illinois since 1982. He has been Associate of Clinical
Obstetrics and Gynecology in the Department of Obstetrics and Gynecology at both
Northwestern University Hospital and the Northwestern University Medical School
since 1982, and has been a Fellow at the American College of Obstetrics and
Gynecology since 1985.
 
     Robert J. Towarnicki, 47, has served as Chief Executive Officer and a
director of the Company since October 1996 and as President of the Company since
January 1998. Prior to joining the Company, from 1992 to 1996, he served as
President, Chief Operating Officer, a director and most recently as Executive
Vice
                                        4
<PAGE>   8
 
President of Integra LifeSciences Corporation, which is the publicly held parent
firm for a group of biotechnology and medical device companies including
Collatech, Inc., ABS LifeSciences Inc., Telios Pharmaceuticals, Inc. and
Vitaphore Corporation. In addition, from 1991 to 1992, he served as Founder,
President and Chief Executive Officer of MediRel, Inc. From 1989 to 1991, he was
General Manager of Focus/MRL, Inc.; from 1985 to 1989, he was Vice President of
Development and Operations for Collagen Corporation; and from 1974 to 1985, he
held a variety of operations management positions at Pfizer, Inc. and Merck &
Co., Inc.
 
     Richard H. Troy, 61, has served as Senior Vice President -- Corporate
Development of the Company since November 1997, Vice President -- Finance, Law
and Administration from January 1993 until November 1997, and General Counsel,
Secretary and a director of the Company since December 1992. He has been an
advisor to the Company since its inception in 1990, and he is a director and
President of FGN, Inc., the predecessor partnership's first general partner and
a principal stockholder of the Company. Prior to joining the Company, from 1990
to 1992, he served as Vice President and Associate General Counsel of UST, Inc.
From 1973 to 1990, he worked at Combustion Engineering, Inc., most recently as
Vice President and Deputy General Counsel. From 1964 to 1973, he practiced law
with the firm of Shearman & Sterling in New York City.
 
     Louis M. Weiner, M.D., 47, has served as a director of the Company and as a
member of the Company's scientific advisory board since the latter part of 1998.
He has served as the Chairman of the Department of Medical Oncology, Division of
Medical Science at Fox Chase Cancer Center since 1994 and has been on staff at
Fox Chase Cancer Center since 1984. Since 1995, Dr. Weiner has been a Professor
in the Department of Medicine, Temple University School of Medicine. Since 1995,
he has chaired the Biologic Response Modifiers Committee and the Translational
Research Committee of the Eastern Cooperative Oncology Group.
 
MEETINGS AND COMMITTEES OF THE BOARD OF DIRECTORS
 
     During 1998, the Board held eleven Board meetings and seven committee
meetings. All directors were able to attend 75% or more of the total Board
meetings and meetings of committees of which they were members, with the
exception of Mr. Ross who attended nine of fourteen overall meetings, Dr. Toig
who attended eight of eleven overall meetings and Dr. Weiner who was unable to
attend the one meeting which occurred after his election to the Board. In
addition, the Board took action by unanimous written consent of all directors on
eight occasions.
 
     The Compensation and Stock Option Committee of the Board determines the
salaries and bonuses of the elected officers of the Company and administers the
1997 Equity Incentive Plan. This Committee, consisting of Messrs. Boeger, Quy,
Ross and Schiff, met six times in 1998. The Audit Committee of the Board confers
with the Company's outside auditors with respect to the financial statements,
the scope and results of the annual audit and matters pertaining to the internal
accounting function. This Committee, consisting of Messrs. Boeger, Gibbons and
Gibson, met once during 1998. The Board selects nominees for election to the
Board and has not formed a nominating committee.
 
COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION
 
     No member of the Compensation and Stock Option Committee is a current or
former officer or employee of the Company. The members of this committee are
Messrs. Boeger, Quy, Schiff and Ross. During 1998, funds represented by Mr.
Schiff invested in the Company, as described under "Related Transactions" below.
 
COMPENSATION OF DIRECTORS
 
     The Company's directors do not currently receive any compensation for
service on the Board or any committee thereof except that non-employee directors
receive stock options pursuant to the 1997 Non-Employee Directors' Stock Option
Plan (the "Directors' Plan"). Non-employee directors are reimbursed for certain
expenses in connection with attendance at the Company's Board and committee
meetings. Directors who are employees of the Company do not receive separate
compensation for their services as directors.
                                        5
<PAGE>   9
 
     The Directors' Plan was adopted by the Board on October 14, 1997 and
approved by the Company's stockholders shortly thereafter. This Plan provides
for the automatic grant of options to purchase shares of the Company's Common
Stock to non-employee directors of the Company. The Directors' Plan is
administered by the Board, unless the Board delegates administration to a
committee.
 
     Each person who first becomes a non-employee director is automatically
granted an option to purchase 18,157 shares of Common Stock (the "Inaugural
Grant"). In addition, on the date of each annual stockholder meeting, each
non-employee director who has served at least one full year as a director is
automatically granted an option to purchase 5,447 shares of Common Stock (the
"Anniversary Grant"). Options subject to an Inaugural Grant under the Directors'
Plan vest in three equal, annual installments commencing on the first
anniversary of the date of the grant of the option. Options subject to an
Anniversary Grant under the Directors' Plan vest in full on the first
anniversary of the date of the grant of the option. The vesting of all options
under the Directors' Plan is conditioned on the continued service of the
recipient as a director, employee or consultant of the Company or any affiliate
of the Company through the respective vesting dates.
 
     The exercise price of the options granted under the Directors' Plan is
equal to the fair market value of the Common Stock on the date of grant. No
option granted under the Directors' Plan may be exercised after the expiration
of 10 years from the date it was granted. In the event of certain changes of
control, options outstanding under the Directors' Plan will automatically become
fully vested and will terminate if not exercised prior to such change of
control.
 
     At the time Dr. Weiner agreed to become a member of the Board he also
agreed to become a member of the Company's scientific advisory board. In the
latter capacity, Dr. Weiner received a stock option, vesting over three years,
to acquire 13,750 shares of Common Stock at $6.60 per share, the fair market
value on the date of the grant, and is compensated at the rate of $4,000 per
quarter.
 
                                        6
<PAGE>   10
 
         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
 
     The following table sets forth certain information regarding the beneficial
ownership of Common Stock as of February 28, 1999 as to each person who owns
more than five percent of the outstanding Common Stock of the Company and each
person who is a director or executive officer of the Company, and all directors
and executive officers as a group.
 
<TABLE>
<CAPTION>
                                                                   AMOUNT AND
                                                                   NATURE OF
BENEFICIAL OWNER AND ADDRESS(1)                               BENEFICIAL OWNERSHIP    PERCENT
- -------------------------------                               --------------------    -------
<S>                                                           <C>                     <C>
Gem Capital Management, Inc.(2).............................       1,780,939            7.3%
70 East 55th Street, 12th Floor
New York, NY 10022
FGN, Inc....................................................       1,772,186            7.3%
c/o Mayer, Brown & Platt
190 S. LaSalle Street
Chicago, IL 60603
Attn: Michael P. Cannon, Esq
William A. Boeger(3)........................................         335,294            1.4%
John J. Gibbons(4)..........................................         108,036              *
Thomas M. Gibson(5).........................................         113,725              *
Brian J. Hayden(6)..........................................          41,041              *
Judith A. Hemberger, Ph.D.(7)...............................           2,635              *
Rifat Pamukcu, M.D.(8)......................................         390,290            1.6%
Roger J. Quy, Ph.D.(9)......................................         966,709            4.0%
Bruce R. Ross(6)............................................           6,052              *
Peter G. Schiff(10).........................................       1,212,674            4.9%
Randall M. Toig, M.D.(11)...................................         142,467              *
Robert J. Towarnicki(12)....................................         243,196            1.0%
Richard H. Troy(13).........................................       2,091,984            8.6%
Louis M. Weiner, M.D........................................              --              *
All executive officers and directors (13 persons)(14).......       5,650,103           22.9%
</TABLE>
 
- ---------------
   * Indicates beneficial ownership of less than one percent.
 
  ** The address of the directors and executive officers is 702 Electronic
     Drive, Horsham, PA 19044.
 
 (1) This table is based upon information supplied by officers, directors and
     principal stockholders. Unless otherwise indicated in the footnotes to this
     table and subject to community property laws where applicable, the Company
     believes that each of the stockholders named in this table has sole voting
     and investment power with respect to the shares indicated as beneficially
     owned. Applicable percentages are based on 24,315,013 shares of Common
     Stock outstanding as of February 28, 1999, adjusted as required by the
     rules promulgated by the Securities and Exchange Commission.
 
 (2) Includes 1,674,254 shares and warrants to purchase 52,631 shares
     beneficially owned by Oak Tree Partners, L.P., an entity that may be deemed
     an affiliate of Gem Capital Management, Inc. and 54,054 shares beneficially
     owned by Gem Capital Management, Inc. Profit Sharing Plan. Gem Capital
     Management, Inc. disclaims beneficial ownership of such shares except to
     the extent of its pecuniary interest therein.
 
 (3) Includes 13,379 shares and options to purchase 5,447 shares owned of record
     by Mr. Boeger, 187,982 shares owned of record by Quest Ventures II and
     128,486 shares owned of record by Quest Ventures International. Mr. Boeger
     is a managing general partner of Quest Ventures II and Quest Ventures
     International, and may be deemed to share voting and investment power with
     respect to such shares. Mr. Boeger disclaims beneficial ownership of such
     shares except to the extent of his pecuniary interest therein.
 
                                        7
<PAGE>   11
 
 (4) Includes options to purchase 108,032 shares of Common Stock.
 
 (5) Includes options to purchase 5,447 shares and warrants to purchase 1,288
     shares beneficially owned by Thomas M. Gibson and 106,690 shares in the
     Thomas M. Gibson Trust established by Thomas M. Gibson.
 
 (6) Represents options to purchase shares of Common Stock.
 
 (7) Includes 635 shares owned jointly with Ms. Hemberger's mother.
 
 (8) Includes options to purchase 100,150 shares, 48,750 of which are unvested
     and would currently be subject to a repurchase option by the Company.
 
 (9) Includes options to purchase 5,447 shares beneficially owned by Roger Quy
     and 961,262 shares owned of record by Technology Partners. Dr. Quy is a
     general partner of Technology Partners, and may be deemed to share voting
     and investment power with respect to such shares. Dr. Quy disclaims
     beneficial ownership of such shares except to the extent of his pecuniary
     interest therein.
 
(10) Includes options to purchase 5,447 shares of Common Stock beneficially
     owned by Peter Schiff, 918,808 shares and warrants to purchase 9,263 shares
     owned of record by Northwood Ventures LLC, 130,600 shares and warrants to
     purchase 1,802 shares owned of record by Northwood Capital Partners LLC,
     118,000 shares and warrants to purchase 1,754 shares owned of record by
     Rabbit Hollow Partners and 27,000 shares owned of record by the Edward T.
     Schiff et. al. Trust. Mr. Schiff is the President of Northwood Ventures
     LLC, the President of Northwood Capital Partners LLC, the Managing General
     Partner of Rabbit Hollow Partners and the Trustee of the Edward T. Schiff
     et. al. Trust; he may be deemed to share voting and investment power with
     respect to such shares. Mr. Schiff disclaims beneficial ownership of such
     shares except to the extent of his pecuniary interest therein.
 
(11) Includes options to purchase 5,447 shares of Common Stock and 676 shares
     issuable upon exercise of outstanding warrants.
 
(12) Includes 72,917 shares subject to repurchase by the Company and options to
     purchase 54,000 shares. Also includes 1,860 shares beneficially owned by
     Mr. Towarnicki's son and 1,860 shares owned by Mr. Towarnicki's daughter,
     with respect to which shares Mr. Towarnicki disclaims beneficial ownership
     except to the extent of his pecuniary interest therein.
 
(13) Includes 25,000 shares subject to repurchase by the Company, options to
     purchase 20,000 shares, 7,500 of which are unvested and would be subject to
     a repurchase option by the Company. Also includes 27,250 shares
     beneficially owned by Mr. Troy's spouse, and 17,100 shares beneficially
     owned by Mr. Troy's daughter, as well as 1,772,186 shares owned of record
     by FGN, Inc., of which Mr. Troy is a director and the President. Mr. Troy
     may be deemed to share voting and investment power with respect to such
     44,350 shares beneficially owned by his spouse and daughter and to such
     1,772,186 shares beneficially owned by FGN, Inc.; however, Mr. Troy
     disclaims beneficial ownership of such shares except to the extent of his
     pecuniary interest therein.
 
(14) Includes shares and options or warrants to purchase 371,969 shares held by
     directors and executive officers of the Company, entities affiliated with
     such persons and director nominees. See Notes 3 through 13 above.
 
                                        8
<PAGE>   12
 
COMPENSATION OF THE CHIEF EXECUTIVE OFFICER AND EXECUTIVE OFFICERS OF THE
COMPANY
 
     The following table sets forth for the fiscal years ended December 31,
1998, 1997 and 1996, the compensation for services rendered to the Company
awarded or paid to, or earned by, the Chief Executive Officer and each executive
officer of the Company who was serving as of the end of the 1998 fiscal year.
 
                           SUMMARY COMPENSATION TABLE
 
<TABLE>
<CAPTION>
                                     ANNUAL COMPENSATION            LONG TERM COMPENSATION
                              ----------------------------------   -------------------------
                                                                                  SECURITIES       ALL
                                                                                  UNDERLYING      OTHER
NAME AND PRINCIPAL POSITION   FISCAL YEAR    SALARY      BONUS     STOCK AWARDS    OPTIONS     COMPENSATION
- ---------------------------   -----------   --------    --------   ------------   ----------   ------------
<S>                           <C>           <C>         <C>        <C>            <C>          <C>
Robert J. Towarnicki........     1998       $195,000    $115,000     $    --       120,000       $25,000(5)
  Chief Executive Officer;       1997        175,000      40,000          --       100,000            --
  President                      1996         32,532(1)       --          --       175,000

Rifat Pamukcu, M.D. ........     1998        175,000      75,000          --        80,000            --
  Chief Scientific Officer;      1997        145,000      25,000          --        25,000            --
  Senior Vice President --       1996        145,000      25,000(2)    12,800(3)    60,000            --
  Research and Development

Richard H. Troy.............     1998        160,000      62,500          --        50,000            --
  Senior Vice President --       1997        140,000      25,000          --        10,000            --
  Corporate Development;         1996        140,000      25,000(2)    12,800(3)    50,000            --
  General Counsel; Secretary

Brian J. Hayden.............     1998        155,000      42,500          --        30,000            --
  Chief Financial Officer;       1997         21,760(4)   15,000          --        90,785            --
  Vice President -- Finance;     1996             --          --          --            --            --
  Treasurer
</TABLE>
 
- ---------------
(1) Robert J. Towarnicki began serving as Chief Executive Officer in October
    1996.
 
(2) In February 1996, the Compensation and Stock Option Committee awarded cash
    bonuses with respect to services rendered during the 1993-1995 period.
 
(3) In March 1996, pursuant to the 1995 Stock Award Plan, the Compensation and
    Stock Option Committee awarded 40,000 shares of Common Stock with respect to
    services rendered during the 1993-1995 period. The fair market value of such
    stock awards was $0.32 per share, as determined by the Board.
 
(4) Brian J. Hayden began serving as Chief Financial Officer and Vice President,
    Finance in November 1997.
 
(5) Represents relocation expenses paid by the Company to Mr. Towarnicki
    pursuant to his employment agreement.
 
EXECUTIVE EMPLOYMENT AGREEMENTS
 
     In November 1997, the Company entered into an employment agreement with
Brian J. Hayden providing for initial annual compensation of $155,000 and up to
20% of base compensation as an annual bonus, an option to purchase 90,785 shares
of Common Stock at $4.75 per share subject to a four year vesting schedule, a
sign-on bonus of $15,000, and a severance payment equal to six months of salary
and twelve months of health care premiums in the event of termination without
cause.
 
     In October 1996, the Company entered into an employment agreement with
Robert J. Towarnicki providing for initial annual compensation of $175,000 and
up to $35,000 as an annual bonus, an option to purchase up to 175,000 shares of
the Company's Common Stock at $0.50 per share subject to a four-year vesting
schedule, certain relocation expenses and a severance payment equal to six
months of salary and vesting of at least 87,500 options in the event of
termination without cause.
 
     In February 1993, the Company entered into an employment agreement with
Rifat Pamukcu providing for initial annual compensation of $110,000 and up to
$30,000 as an annual bonus, certain relocation expenses and a severance payment
equal to nine months of salary in the event of involuntary termination or
termination by Dr. Pamukcu for good reason.
 
                                        9
<PAGE>   13
 
     In January 1993, the Company entered into a memorandum of employment with
Richard H. Troy providing for initial annual compensation of $110,000, up to
$30,000 as an annual bonus, and a severance payment equal to six months of
salary and benefits in the event of termination without cause or termination by
Mr. Troy for good reason.
 
STOCK OPTION GRANTS TO AND EXERCISES BY EXECUTIVES
 
     The Company grants options to its executive officers and employees under
its 1997 Equity Incentive Plan (the "Plan"). As of March 1, 1999, options to
purchase a total of 1,177,071 shares of Common Stock were outstanding under the
Plan and options to purchase 663,329 shares of Common Stock remained available
for grant thereunder. The following tables show for the fiscal year ended
December 31, 1998 certain information regarding options granted to, exercised by
and held at such dates by the Chief Executive Officer and the executive officers
of the Company.
 
                       OPTION GRANTS IN LAST FISCAL YEAR
 
<TABLE>
<CAPTION>
                                                                                     POTENTIAL REALIZABLE VALUE
                                       PERCENT OF                                      AT ASSUMED ANNUAL RATES
                                      TOTAL OPTIONS                                  OF STOCK PRICE APPRECIATION
                         NUMBER OF     GRANTED TO     EXERCISE OR                        FOR OPTION TERM(3)
                          OPTIONS     EMPLOYEES IN     BASE PRICE     EXPIRATION     ---------------------------
NAME                     GRANTED(1)    FISCAL YEAR    ($/SHARE)(2)      DATE(1)           5%            10%
- ----                     ----------   -------------   ------------   -------------   ------------   ------------
<S>                      <C>          <C>             <C>            <C>             <C>            <C>
Robert Towarnicki......   120,000         20.3%          $6.60       June 22, 2008    $1,290,085     $2,054,244
Rifat Pamukcu, M.D. ...    80,000         13.5            6.60       June 22, 2008       860,056      1,369,496
Richard H. Troy........    50,000          8.4            6.60       June 22, 2008       537,535        855,935
Brian J. Hayden........    30,000          5.1            6.60       June 22, 2008       322,521        513,561
</TABLE>
 
- ---------------
(1) Options granted pursuant to the Plan expire ten years after the date of
    grant and, in general, vest at a rate of 25% annually upon each anniversary
    over a four-year period.
 
(2) All grants were made at 100% of fair market value as of the date of grant.
 
(3) The potential realizable value is calculated assuming that the fair market
    value of Common Stock, on the date of the grant as determined by the Board,
    appreciates at the indicated annual rate compounded annually for the entire
    term of the option and that the option is exercised and the Common Stock
    received therefore is sold on the last day of the term of the option for the
    appreciated price. The 5% and 10% rates of appreciation are mandated by the
    rules of the Commission and do not represent the Company's estimate or
    projection of future increases in the price of Common Stock.
 
   AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR AND YEAR-END OPTION VALUES
 
<TABLE>
<CAPTION>
                                                                NUMBER OF            VALUE OF UNEXERCISED
                                                           UNEXERCISED OPTIONS      IN- THE-MONEY OPTIONS
                                  SHARES                   AT DECEMBER 31, 1998      AT DECEMBER 31, 1998
                                 ACQUIRED       VALUE          EXERCISABLE/              EXERCISABLE/
NAME(1)                         ON EXERCISE    REALIZED      UNEXERCISABLE(1)          UNEXERCISABLE(2)
- -------                         -----------    --------    --------------------    ------------------------
<S>                             <C>            <C>         <C>                     <C>
Robert J. Towarnicki..........      --           --           54,000/166,000         $ 988,200/$2,689,800
Rifat Pamukcu, M.D. ..........      --           --          100,150/ 64,850         1,991,610/   998,690
Richard H. Troy...............      --           --           20,000/ 40,000           337,000/   616,000
Brian J. Hayden...............      --           --           41,041/ 79,744           703,157/ 1,324,885
</TABLE>
 
- ---------------
(1) All options are subject to vesting; however, with respect to options granted
    prior to August 1997 early exercise is possible with portions thereof
    remaining subject to a repurchase option by the Company.
 
(2) To date, all options have been granted at exercise prices equal to the fair
    market value per share of Common Stock, as determined by the Board; the
    Company's closing stock price at December 31, 1998 was $22.00 per share.
 
                                       10
<PAGE>   14
 
                         COMPENSATION COMMITTEE REPORT
 
     The Compensation and Stock Option Committee (the "Committee") of the Board
determines the compensation of Cell Pathways' executive officers. All members of
the Committee during 1998 were non-employee directors. The Committee consists of
William A. Boeger, Peter G. Schiff, Roger J. Quy and Bruce R. Ross. Pursuant to
rules adopted by the Securities and Exchange Commission, the Committee furnishes
the following report on executive compensation.
 
COMPENSATION PHILOSOPHY
 
     Cell Pathways' executive compensation program seeks to accomplish several
major goals:
 
     - To align the interests of executive officers with the long-term interests
       of stockholders through participation in the Company's long-term, equity
       based incentive compensation programs, principally stock options.
 
     - To motivate executives to achieve key business objectives and to reward
       them when such objectives are met.
 
     - To recruit and retain highly qualified executive officers by offering
       compensation that is competitive with that offered for comparable
       positions in comparable development stage biotechnology and
       pharmaceutical companies.
 
In reviewing the compensation packages for each executive officer, the Committee
reviewed information from published surveys and data provided by corporate
advisors. Factors that are considered in determining salary, incentive awards
and stock options include but are not limited to: company size; stage of
development; and geographic location. The Company competes for executive talent
with biotechnology and pharmaceutical companies in the Philadelphia region; the
compensation package paid by such companies is a factor in attracting and
retaining executive talent.
 
BASE SALARY
 
     Base salary represents the fixed component of the executive compensation
program. Base salaries of the chief executive officer and senior management are
determined by reviewing comparable market base salary compensation, individual
performance, relevant experience and demonstrated capabilities in meeting the
requirements of the position. The Chief Executive Officer's base salary is
determined by the Committee's evaluation of his attainment of stated overall
goals and targets for the Company and his individual contribution and
performance.
 
LONG TERM INCENTIVES
 
     Stock option awards within the approved Company plans are designed to align
the long-term interest of the Company's executives with those of its
stockholders. Stock options are used as a mechanism to attract executives to the
Company and to be competitive with other biotechnology companies in the region.
In addition, based on the attainment of corporate goals or individual
accomplishments, the Committee may use stock options as a further incentive for
the executives.
 
CASH BONUSES
 
     The Committee believes that discretionary cash bonuses are important to
motivate and reward executive officers. Cash bonuses are based on significant
achievements and are not guaranteed. Annual cash bonuses may be awarded to
executives based on attainment of Company-wide and individual goals and
objectives.
 
COMPENSATION OF THE CHIEF EXECUTIVE OFFICER
 
     Mr. Towarnicki's compensation for 1998 was determined based on his
experience in the industry and his accomplishments in 1998. Compensation awarded
to Mr. Towarnicki in 1998 was comprised of a base salary, stock options and a
performance bonus based on near-term accomplishments. Mr. Towarnicki's salary
for
                                       11
<PAGE>   15
 
1998 was $195,000 which was adjusted on January 1, 1999 to $265,000 to better
align him with his peer group and to reflect significant accomplishments made in
1998. Additionally, Mr. Towarnicki received an incentive bonus of $115,000 and a
stock option award of 120,000 shares related to his accomplishments in 1998. The
Committee made these adjustments based on the following accomplishments:
 
     - Completed a private round of financing which raised approximately $21
       million of capital.
 
     - Completed the acquisition of Tseng, which provided the Company with
       approximately $27 million in capital.
 
     - Accelerated the Company's clinical development programs in prostate,
       colon, breast and lung cancer indications.
 
     - Expanded the Company's research and development activities and
       consolidated its operations in its new facility in Horsham, Pa.
 
     - Recruited essential employees in the development of an experienced
       management team to prepare the Company for development and potential
       commercialization.
 
     The members of the Committee who are listed below have furnished the
foregoing report.
 
                                          William A. Boeger
                                          Roger J. Quy
                                          Bruce R. Ross
                                          Peter G. Schiff
 
                                       12
<PAGE>   16
 
                      STOCKHOLDER RETURN PERFORMANCE GRAPH
 
     The graph below compares the cumulative total stockholder return on the
Company's Common Stock from the commencement of public trading on November 4,
1998 through December 31, 1998 with the cumulative total return of the Nasdaq
Stock Market -- U.S. Index and the Nasdaq Pharmaceuticals Index. The graph
assumes a $100 investment made at the beginning of the period and reinvestment
of all dividends. The comparisons depicted in the graph are required by the
Securities and Exchange Commission and are not intended to forecast or be
indicative of possible future performance of the Company's Common Stock.
 
<TABLE>
<CAPTION>
                                                      NASDAQ US            NASDAQ PHARMACEUTICALS               CLPA
                                                      ---------            ----------------------               ----
<S>                                                   <C>                         <C>                         <C>
11/4/98                                                100.000                     100.000                     100.000
11/13/98                                               101.566                     101.903                      86.260
11/20/98                                               105.862                     102.618                      67.176
11/27/98                                               110.507                     102.657                      70.992
12/4/98                                                109.916                     104.075                      68.702
12/11/98                                               111.663                     106.323                      85.496
12/18/98                                               114.726                     108.026                      93.130
12/24/98                                               118.877                     113.416                     103.053
12/31/98                                               120.551                     120.123                     134.351
</TABLE>
 
                                       13
<PAGE>   17
 
                              RELATED TRANSACTIONS
 
     In April and May of 1998, the Company, while still a privately held
company, issued a total of 4,645,879 shares of Series G Preferred Stock and
warrants to purchase 227,793 shares of Series G Preferred Stock to institutional
investors and stockholders with preemptive rights. Certain directors, executive
officers and (then) five percent stockholders of the Company participated in the
private offering as follows: Northwood Ventures LLC and Northwood Capital
Partners LLC, which together with affiliated funds was a holder of more than
five percent of the Company's voting stock and the President of which is Peter
G. Schiff, a director of the Company, purchased 105,263 and 21,053 shares,
respectively, of Series G Preferred Stock and warrants to purchase Series G
Preferred Stock; Rabbit Hollow Partners, a general partner of which is Peter G.
Schiff, a director of the Company, purchased 20,096 shares of Series G Preferred
Stock and warrants to purchase Series G Preferred Stock; The Goldman Sachs
Group, L.P., which was a holder of more than five percent of the Company's
voting stock, purchased 315,790 shares of Series G Preferred Stock and warrants
to purchase Series G Preferred Stock and, in recognition of its efforts in
connection with the offering, received a warrant to purchase 5,000 shares of
Common Stock; Gem Capital Management, which is a holder of more than five
percent of the Company's voting stock, purchased 1,052,632 shares of Series G
Preferred Stock and warrants to purchase Series G Preferred Stock; Richard H.
Troy, a director, Senior Vice President -- Corporate Development, General
Counsel and Secretary of the Company, purchased 2,000 shares of Series G
Preferred Stock and warrants to purchase Series G Preferred Stock; Grosvenor G.
Nichols, a brother-in-law of Richard H. Troy, purchased 26,335 shares of Series
G Preferred Stock and warrants to purchase Series G Preferred Stock; and Thomas
M. Gibson, a director of the Company, purchased 25,777 shares of Series G
Preferred Stock and warrants to purchase Series G Preferred Stock.
 
     In November 1998, the Company redeemed its outstanding Redeemable Preferred
Stock, half in cash and half in Common Stock of the Company. All of the
Redeemable Preferred Stock had been held by FGN, Inc., the first general partner
of the partnership predecessor of the Company and currently a holder of more
than five percent of the Common Stock of the Company. Pursuant to arrangements
entered into in 1990 with certain persons who participated in the founding of
the business of the Company, FGN, Inc. immediately paid out all but $75,000
worth of the proceeds of the redemption of the Redeemable Preferred Stock to or
on behalf of such persons, including the payment of approximately $75,000 cash
and 4,540 shares of Common Stock to Rifat Pamukcu, Chief Scientific Officer and
Senior Vice President -- Research and Development of the Company, and the
payment of approximately $50,000 and 3,027 shares of Common Stock to Richard H.
Troy, a director, Senior Vice President -- Corporate Development, General
Counsel and Secretary of the Company and a director, the president and a
stockholder of FGN, Inc.
 
                                 OTHER BUSINESS
 
     The Board knows of no other business which will come before the meeting. If
any other business shall properly come before the meeting, your authorized
proxies will vote thereon in accordance with their best judgement.
 
     The Bylaws of the Company provide that no business may be conducted at an
annual meeting unless properly brought before the meeting. For business to be
properly brought before an annual meeting, it must be specified in the notice of
meeting, be otherwise brought before the meeting by or at the direction of the
Board or be otherwise properly brought before the meeting by a stockholder. For
business to be properly brought before an annual meeting by a stockholder, the
stockholder must have given timely notice thereof in writing which must be
received by the Secretary of the Company at the principal executive offices of
the Company not later than the close of business on the sixtieth (60th) day, and
not earlier than the close of business on the ninetieth (90th) day, prior to the
anniversary of the preceding year's annual meeting, which would mean between
March 24 and April 23, 2000, subject to adjustment if the meeting date is
substantially changed from the date in 1999. The stockholder's notice to the
Secretary must set forth with respect to each proposed matter a brief
description of the matter, the reasons for conducting the business at an annual
meeting, the name and address of the proposing stockholder as they appear on the
books of the Company, the number of shares beneficially owned by the proposing
stockholder, any material interest of the stockholder in the matter
 
                                       14
<PAGE>   18
 
proposed, and any other information required to be provided pursuant to
Regulation 14A under the Securities Exchange Act of 1934. The chairman of an
annual meeting shall determine whether proposed business is properly brought
before the meeting. If the Company has not received notice of a matter prior to
the close of business in the sixtieth day prior to an annual meeting, proxies
received by the Company with respect to such annual meeting may, and unless
otherwise directed, confer discretionary voting with respect to such matter.
 
                        INFORMATION CONCERNING AUDITORS
 
     The firm of Arthur Andersen LLP, independent accountants, has audited the
Company's financial statements since the inception of the Company. Later in
1999, the Audit Committee of the Board will select auditors for the fiscal year
1999. Representatives of Arthur Andersen LLP, have been invited to attend the
Annual Meeting, will have an opportunity to make a statement if they desire to
do so, and will be available to respond to appropriate questions.
 
                             COSTS OF SOLICITATION
 
     The Company will pay the costs of soliciting proxies, including printing,
handling and mailing of this Proxy Statement, the proxy and related material
furnished to stockholders. Copies of solicitation materials will be furnished to
banks, brokerage houses, custodians, nominees and fiduciaries holding shares of
Common Stock in their names which are beneficially owned by others to forward to
such beneficial owners. The Company may reimburse persons representing
beneficial owners for their costs of forwarding proxy material to the beneficial
owners. Certain officers, directors and regular employees of the Company may
solicit proxies by telephone, telegraph, facsimile or in person. These persons
will receive no extra compensation for their services.
 
                             STOCKHOLDER PROPOSALS
 
     Proposals of stockholders of the Company which are intended to be presented
by such stockholders at the Company's 2000 annual meeting of stockholders must
be received by the Secretary of the Company no later than December 31, 1999 in
order to be included in the Company's proxy statement and form of proxy relating
to that meeting.
 
                                          By Order of the Board of Directors,
 
                                          Richard H. Troy
                                          Secretary
 
Horsham, Pennsylvania
April 30, 1999
 
                                       15
<PAGE>   19

 ---  PLEASE MARK VOTES                       CELL PATHWAYS, INC.
| X | AS IN THIS EXAMPLE           PROXY SOLICITED BY THE BOARD OF DIRECTORS
 --- 
<TABLE>
<S>                                                  <C>
                                                                                   For          Withhold        For All
                                                                                   All          For All        Nominees
                                                                                 Nominees       Nominees        Except
ANNUAL MEETING OF STOCKHOLDERS                       Proposal 1:                 --------       --------       --------
       JUNE 22, 1999                                    Election of Directors:  |        |     |        |     |        |
                                                                                |        |     |        |     |        |
                                                                                 --------       --------       --------

     The undersigned stockholder of Cell Pathways,                          Thomas M. Gibson  Roger J. Quy   Randall M. Toig, M.D.
Inc., a Delaware corporation ("CPI"), hereby 
acknowledges receipt of the Notice of the 1999                              INSTRUCTION: To withhold authority to vote for any 
Annual Meeting of Stockholders and Proxy Statement                          individual nominee, mark "For All Nominees Except"
of CPI, and hereby appoints Robert J. Towarnicki,                           and write that nominee's name in the space provided
Brian J. Hayden and Richard H. Troy, and each of                            below.
them, proxies and attorneys-in-fact, with full power 
of substitution to each, on behalf and in the name of                       --------------------------------------------------------
the undersigned, to represent the undersigned at the 
1999 Annual Meeting of Stockholders of CPI, to be                             THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" THE
held at the Rittenhouse Hotel, 210 West Rittenhouse                         PROPOSAL LISTED ABOVE.
Square, Philadelphia, Pennsylvania, on June 22, 1999, 
at 10:00 a.m., local time, and at any and all                                 UNLESS A CONTRARY DIRECTION IS INDICATED, THIS PROXY 
postponements, continuations and adjournments thereof,                      WILL BE VOTED "FOR" PROPOSAL 1, AS MORE SPECIFICALLY 
and to vote all shares of common stock which the                            DESCRIBED IN THE PROXY STATEMENT. IF SPECIFIC
undersigned may be entitled to vote if then and there                       INSTRUCTIONS ARE INDICATED, THIS PROXY WILL BE VOTED IN
personally present, with all powers that the                                ACCORDANCE THEREWITH. IF ANY OTHER MATTERS SHOULD
undersigned would possess if personally present, upon                       PROPERLY COME BEFORE THE CPI ANNUAL MEETING, THIS PROXY
and in respect of the following matters and in                              WILL BE VOTED WITH RESPECT TO SUCH MATTERS IN ACCORDANCE
accordance with the following instructions, with                            WITH THE JUDGMENT OF THE PERSONS VOTING SUCH PROXIES.
discretionary authority as to any and all other matters 
that may properly come before the meeting.


Please be sure to sign and date ---------------------------------
this Proxy in the box below.    |Date                            |
                                |                                |
- -----------------------------------------------------------------             Signature should be exactly as your name(s) appear on 
|                                                                |          proxy. If stock is held jointly, each holder should 
|                                                                |          sign. If signing as attorney, executor, administrator, 
|                                                                |          trustee or guardian, please give full title.
- ----Stockholder sign above----Co-holder (if any) sign above------


                          *  Detach above card, sign, date and mail in postage paid envelope provided.  *
                                                        CELL PATHWAYS, INC.
- ------------------------------------------------------------------------------------------------------------------------------------
|                                                       PLEASE ACT PROMPTLY                                                        |
|                                             SIGN, DATE & MAIL YOUR PROXY CARD TODAY                                              |
- ------------------------------------------------------------------------------------------------------------------------------------
</TABLE>


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