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<TABLE> <S> <C>
<PAGE>
<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM MAXYGEN,
INC.'S QUARTERLY REPORT ON FORM 10-Q FOR THE PERIOD ENDED SEPTEMBER 30, 2000 AND
IS QUALIFIED IN ITS ENTIRETY BY REFERENCE TO SUCH FINANCIAL STATEMENTS.
</LEGEND>
<MULTIPLIER> 1,000
<S> <C>
<PERIOD-TYPE> 9-MOS
<FISCAL-YEAR-END> DEC-31-2000
<PERIOD-START> JAN-01-2000
<PERIOD-END> SEP-30-2000
<CASH> 183,131
<SECURITIES> 59,585
<RECEIVABLES> 8,230
<ALLOWANCES> 0
<INVENTORY> 0
<CURRENT-ASSETS> 252,042
<PP&E> 10,034
<DEPRECIATION> 2,390
<TOTAL-ASSETS> 321,015
<CURRENT-LIABILITIES> 14,148
<BONDS> 0
0
0
<COMMON> 3
<OTHER-SE> 302,343
<TOTAL-LIABILITY-AND-EQUITY> 321,015
<SALES> 0
<TOTAL-REVENUES> 17,531
<CGS> 0
<TOTAL-COSTS> 0
<OTHER-EXPENSES> 75,068
<LOSS-PROVISION> 0
<INTEREST-EXPENSE> 166
<INCOME-PRETAX> (46,731)
<INCOME-TAX> 0
<INCOME-CONTINUING> (46,731)
<DISCONTINUED> 0
<EXTRAORDINARY> 0
<CHANGES> 0
<NET-INCOME> (46,731)
<EPS-BASIC> (1.57)
<EPS-DILUTED> (1.57)
</TABLE>
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