INVITROGEN CORP
POS EX, EX-10.1, 2000-08-14
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                                                  EXHIBIT 10.1

                            FIRST AMENDMENT TO THE
                            INVITROGEN CORPORATION
                      1998 EMPLOYEE STOCK PURCHASE PLAN

         Pursuant to Section 22 of the Invitrogen Corporation 1998 Employee
Stock Purchase Plan (the "Plan"), said Plan is hereby amended as follows:

         1.  Section 4.1 shall be amended to state in its entirety as follows:

             4.1  MAXIMUM NUMBER OF SHARES ISSUABLE.  Subject to adjustment
         as provided in Section 4.2, the maximum aggregate number of shares
         of Stock that may be issued under the Plan shall be three hundred
         fifty thousand (350,000) and shall consist of authorized but
         unissued or reacquired shares of Stock, or any combination thereof.
         If an outstanding Purchase Right for any reason expires or is
         terminated or canceled, the shares of Stock allocable to the
         unexercised portion of such Purchase Right shall again be available
         for issuance under the Plan.

         2.  The additional 100,000 shares authorized for issuance under the
Plan by this Amendment may only be issued pursuant to Purchase Rights granted
after the date on which the stockholders of the Company approve this
Amendment.




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