SUNAMERICA STRATEGIC INVESTMENT SERIES INC
497, 2000-10-13
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SUNAMERICA STRATEGIC INVESTMENT SERIES, INC.(R)
SUNAMERICA BIOTECH/HEALTH 30 FUND
Supplement to the Prospectus dated June 14, 2000

     Under the section entitled "SALES CHARGE REDUCTIONS AND
WAIVERS" on page 6 of the Prospectus, the first paragraph should
be replaced in its entirety with the following:

WAIVERS FOR CERTAIN INVESTORS.  Various individuals and
institutions may purchase CLASS A shares without front-end sales
charges, including:

       financial planners, institutions, broker-dealer
       representatives or registered investment advisers
       utilizing Fund shares in fee-based investment products
       under an agreement with the Distributor (this waiver may
       also apply to front-end sales charges of Class II shares)

       participants in certain retirement plans that meet
       applicable conditions, as described in the Statement
       of Additional Information

       Fund Directors and other individuals, and their
       families, who are affiliated with the Fund or any
       Fund distributed by SunAmerica Capital Services,
       Inc.

       selling brokers and their employees and sales
       representatives and their families

We will generally waive the CDSC for CLASS B or CLASS II shares
in the following cases:

       within one year of the shareholder's death or becoming
       disabled

       taxable distributions or loans to participants made
       by qualified retirement plans or retirement accounts
       (not including rollovers) for which SunAmerica Funds
       Services, Inc. serves as a fiduciary and in which
       the plan participant or accountholder has attained
       the age of 591/2 at the time the redemption is made

       Fund Directors and other individuals, and their
       families, who are affiliated with the Fund or any
       Fund distributed by SunAmerica Capital Services,
       Inc.

       to make payments through the Systematic Withdrawal
       Plan (subject to certain conditions)




Dated:  October 2, 2000


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