SunAmerica Strategic Investment Series, Inc.(R)
SunAmerica Biotech/Health 30 Fund
Supplement to the Prospectus dated February 28, 2000
Under the section entitled "ADDITIONAL INVESTOR SERVICES" on
page 16 of the Prospectus, the third paragraph should be replaced
in its entirety with the following:
SYSTEMATIC WITHDRAWAL PLAN may be used for routine bill payment
or periodic withdrawals from your account up to a maximum amount
of 12% per year based on the value of the account at the time the
Plan is established. To use:
Make sure you have at least $5,000 worth of shares in
your account.
Make sure you are not planning to invest more money in
this account (buying shares during a period when you
are also selling shares of the same fund is not
advantageous to you, because of sales charges).
Specify the payee(s) and amount(s). The payee may be
yourself or any other party (which may require a signature
guarantee), and there is no limit to the number of payees
you may have, as long as they are all on the same payment
schedule. Each withdrawal must be at least $50.
Determine the schedule: monthly, quarterly, semi-annually,
annually or in certain selected months.
Make sure your dividends and capital gains are being
reinvested.
You cannot elect the systematic withdrawal plan if you have
requested certificates for your shares.
Dated: October 26, 2000
