SUNAMERICA STRATEGIC INVESTMENT SERIES INC
497, 2000-11-02
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SUNAMERICA STRATEGIC INVESTMENT SERIES, INC. (R)
SUNAMERICA BIOTECH/HEALTH 30 FUND
Supplement to the Prospectus dated June 14, 2000


     Under the section entitled "ADDITIONAL INVESTOR SERVICES" on
page 16 of the Prospectus, the third paragraph should be replaced
in its entirety with the following:

SYSTEMATIC WITHDRAWAL PLAN may be used for routine bill payment or
periodic withdrawals from your account up to a maximum amount of
12% per year based on the value of the account at the time the Plan
is established.  To use:

      Make sure you have at least $5,000 worth of shares in
      your account.

      Make sure you are not planning to invest more money in
      this account (buying shares during a period when you are
      also selling shares of the same fund is not advantageous
      to you, because of sales charges).

      Specify the payee(s) and amount(s). The payee may be
      yourself or any other party, and there is no limit to the
      number of payees you may have, as long as they are all on
      the same payment schedule.  Each withdrawal must be at
      least $50.

      Determine the schedule: monthly, quarterly, semi-annually,
      annually or in certain selected months.

      Make sure your dividends and capital gains are being
      reinvested.

You cannot elect the systematic withdrawal plan if you have
requested certificates for your shares.


Dated:  October 26, 2000



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