SUNAMERICA STRATEGIC INVESTMENT SERIES INC
24F-2NT, 2000-01-11
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U.S. Securities and Exchange Commission, Washington, D.C. 20549

FORM 24F-2: Annual Notice of Securities Sold,
Pursuant to Rule 24f-2

Read instructions at end of Form before preparing Form.  Please
print or type.

     1.   Name and address of issuer:
          SUNAMERICA STRATEGIC INVESTMENT SERIES, INC.
          The SunAmerica Center
          733 Third Avenue
          New York, NY  10017-3204

     2.   The name of each series or class of securities for which this
     Form is filed (If the Form is being filed for all series and
     classes of securities of the issuer, check the box but do not
     list series or classes): [x]

     3.   Investment Company Act File Number:     811-0169

          Securities Act File Number:    333-69517

     4(a).Last day of fiscal year for which this Form is filed:
          10/31/99

     4(b).Check this box if this notice is being filed late (i.e.,
          more than 90 days  after the end of the issuer's fiscal
          year).  (See Instruction A.2.)     [  ]

     4(c).Check this box if this is the last time the issuer will
          be filing this Form. [  ]

     5.   Calculation of registration fee:

     (i)  Aggregate sale price of
          securities sold during the fiscal
          year pursuant to section 24(f):              $ 105,769,709

     (ii) Aggregate price of securities redeemed or
          repurchased during the fiscal year:           $ 28,381,929

     (iii)Aggregate price of securities redeemed or
          repurchased during any prior fiscal year ending
          no earlier than October 11, 1995 that were not
          previously used to reduce registration fees payable
          to the Commission:                            $ -0-

     (iv) Total available redemption credits [add items
          5(ii) and 5(iii):                        $ 28,381,929

     (v)  Net sales - if Item 5(i) is greater than Item 5(iv)
          [subtract Item 5(iv) from Item 5(i)]:        $ 77,387,780

     (vi) Redemption credits available for use in future
          years - if Item 5(i) is less than Item 5(iv)
          [subtract Item 5(iv) from Item 5(i)]:             $  -0-

     (vii)  Multiplier for determining registration fee
           (See Instruction C.9):                            x .000264

     (viii) Registration fee due [multiply Item 5(v) by
            Item 5(vii)] (enter "0" if no fee is due):   $ 20,430.37

    6.     Prepaid Shares                                   -0-

           If the response to item 5(i) as determined by deducting an
           amount of securities that were registered under the Securities
           Act of 1933 pursuant to rule 24e-2 as in effect before
           [effective date of rescission of rule 24e-2], then report the
           amount of securities (number of shares or other units)
           deducted here: -0-.  If there is a number of shares or other
           units that were registered pursuant to rule 24e-2 remaining
           unsold at the end of the fiscal year for which this form is
           filed that are available for use by the issuer in future
           fiscal years, then state that number here: -0-

    7.     Interest due - if this Form is being filed more than 90 days
           after the end of the issuer's fiscal year (see Instruction D):
           N/A

    8.     Total of the amount of the registration fee due plus any
           interest due [line 5(viii) plus line 7]:
           $ 20,430.37

    9.     Date the registration fee and any interest payment was sent to
           the Commission's lockbox depository:
           January 10, 2000
           Method of Delivery:
                         [X] Wire Transfer
                         [ ] Mail or other means

    SIGNATURES

    This report has been signed below by the following persons on
    behalf of the issuer and in the capacities and on the dates
    indicated.


    By (Signature and Title)   /s/ Robert M. Zakem
                               Robert M. Zakem, Secretary

    Dated: January 10, 2000

    * Please print the name and title of the signing officer below the
      signature.



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