SUNAMERICA STRATEGIC INVESTMENT SERIES INC
24F-2NT, 2001-01-12
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 U.S. Securities and Exchange Commission, Washington, D.C. 20549

FORM 24F-2: Annual Notice of Securities Sold,
            Pursuant to Rule 24f-2

Read instructions at end of Form before preparing Form.  Please
print or type.

1.   Name and address of issuer:
          SUNAMERICA STRATEGIC INVESTMENT SERIES, INC.
          The SunAmerica Center
          733 Third Avenue
          New York, NY  10017-3204

2.   The name of each series or class of securities for which
     this Form is filed (If the Form is being filed for all
     series and classes of securities of the issuer, check the
     box but do not list series or classes): [x]

3.   Investment Company Act File Number:     811-0169

     Securities Act File Number:             333-69517

4(a).  Last day of fiscal year for which this Form is filed:
       10/31/00

4(b).  Check this box if this notice is being filed late
       (i.e., more than 90 days  after the end of the issuer's
       fiscal  year).  (See Instruction A.2.)  [  ]

4(c).  Check this box if this is the last time the issuer will
       be filing this Form. [  ]

5.     Calculation of registration fee:

(i)    Aggregate sale price of
       securities sold during the fiscal
       year pursuant to section 24(f):         $ 173,636,528

(ii)   Aggregate price of securities redeemed or
       repurchased during the fiscal year:     $ 57,351,329

(iii)  Aggregate price of securities redeemed or
       repurchased during any prior fiscal year ending
       no earlier than October 11, 1995 that were not
       previously used to reduce registration fees payable
       to the Commission:                      $ -0-

(iv)   Total available redemption credits [add items
       5(ii) and 5(iii):                       $ 57,351,329

(v)    Net sales - if Item 5(i) is greater than Item 5(iv)
       [subtract Item 5(iv) from Item 5(i)]:   $ 116,285,199

(vi)   Redemption credits available for use in future
       years - if Item 5(i) is less than Item 5(iv)
       [subtract Item 5(iv) from Item 5(i)]:   $  -0-

(vii)  Multiplier for determining registration fee
       (See Instruction C.9):                  x .00025

(viii) Registration fee due [multiply Item 5(v) by
       Item 5(vii)] (enter "0" if no fee is due):  $ 29,071.30

6.     Prepaid Shares                                   -0-

       If the response to item 5(i) as determined by deducting an
       amount of securities that were registered under the
       Securities Act of 1933 pursuant to rule 24e-2 as in effect
       before [effective date of rescission of rule 24e-2], then
       report the amount of securities (number of shares or other
       units) deducted here: -0-.  If there is a number of shares
       or other units that were registered pursuant to rule 24e-2
       remaining unsold at the end of the fiscal year for which
       this form is filed that are available for use by the issuer
       in future fiscal years, then state that number here: -0-

7.     Interest due - if this Form is being filed more than 90 days
       after the end of the issuer's fiscal year (see Instruction
       D): N/A

8.     Total of the amount of the registration fee due plus any
       interest due [line 5(viii) plus line 7]:
       $ 29,071.30

9.     Date the registration fee and any interest payment was sent
       to the Commission's lockbox depository:
       January 11, 2001
       Method of Delivery:
            [X] Wire Transfer
            [ ] Mail or other means

SIGNATURES

This report has been signed below by the following persons on
behalf of the issuer and in the capacities and on the dates
indicated.


By (Signature and Title):/s/ Stacey V. Morrison
                         Stacey V. Morrison, Assistant Secretary

Dated: January 12, 2001

* Please print the name and title of the signing officer below
  the signature.



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