SEQUENOM INC
S-1/A, 1999-12-07
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>


 AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON DECEMBER 7, 1999

                                                 REGISTRATION NO. 333-91665
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                ----------------

                              AMENDMENT NO. 1

                                    TO
                                    FORM S-1
                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933
                                ----------------
                                 SEQUENOM, INC.
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

<TABLE>
 <S>                               <C>                              <C>
             DELAWARE                            8731                          77-0365889
 (STATE OR OTHER JURISDICTION OF     (PRIMARY STANDARD INDUSTRIAL           (I.R.S. EMPLOYER
  INCORPORATION OR ORGANIZATION)     CLASSIFICATION CODE NUMBER)         IDENTIFICATION NUMBER)
</TABLE>

                                ----------------

                           11555 SORRENTO VALLEY ROAD
                          SAN DIEGO, CALIFORNIA 92121
                                 (858) 350-0345
  (ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER, INCLUDING AREA CODE, OF
                   REGISTRANT'S PRINCIPAL EXECUTIVE OFFICES)

                                ----------------

                               DR. HUBERT KOSTER
                     PRESIDENT AND CHIEF EXECUTIVE OFFICER
                                 SEQUENOM, INC.
                           11555 SORRENTO VALLEY ROAD
                          SAN DIEGO, CALIFORNIA 92121
                                 (858) 350-0345
 (NAME, ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER, INCLUDING AREA CODE,
                             OF AGENT FOR SERVICE)

                                ----------------
<TABLE>
<S>                                              <C>
             FAYE H. RUSSELL, ESQ.                           ALAN F. DENENBERG, ESQ.
            THOMAS E. HORNISH, ESQ.                            SHEARMAN & STERLING
             ROBERT H. CUTLER, ESQ.                       1550 EL CAMINO REAL, SUITE 100
        BROBECK, PHLEGER & HARRISON LLP                    MENLO PARK, CALIFORNIA 94025
         550 WEST C STREET, SUITE 1300                            (650) 330-2200
          SAN DIEGO, CALIFORNIA 92101
                 (619) 234-1966
</TABLE>
                                ----------------

  APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: As soon as
practicable after the effective date of this Registration Statement.
  If any of the securities being registered on this Form are to be offered on a
delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, check the following box. [_]
  If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, check the following box and
list the Securities Act registration statement number of the earlier effective
registration statement for the same offering. [_]
  If this Form is a post-effective amendment filed pursuant to Rule 462(c)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. [_]
  If this Form is a post-effective amendment filed pursuant to Rule 462(d)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. [_]
  If delivery of the prospectus is expected to be made pursuant to Rule 434,
check the following box. [_]

                                ----------------

  THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT
SHALL FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION
STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE SECURITIES ACT OF 1933, AS AMENDED, OR UNTIL THE REGISTRATION STATEMENT
SHALL BECOME EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO
SECTION 8(A), MAY DETERMINE.

- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
<PAGE>


- -------------------------------------------------------------------------------
PART II

Information not required in prospectus

ITEM 13. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION

The expenses to be paid by the Registrant are as follows. All amounts other
than the SEC registration fee, the NASD filing fees and the Nasdaq National
Market listing fee are estimates.

<TABLE>
<CAPTION>
                                                                       AMOUNT TO
                                                                         BE PAID
- --------------------------------------------------------------------------------
<S>                                                                    <C>
SEC registration fee..................................................  $19,460
NASD filing fee.......................................................    7,500
Nasdaq National Market listing fee....................................        *
Legal fees and expenses...............................................  350,000
Accounting fees and expenses..........................................  250,000
Printing and engraving................................................  260,000
Blue Sky fees and expenses (including legal fees).....................   10,000
Transfer agent fees...................................................   10,000
Miscellaneous.........................................................        *
                                                                       --------
  Total............................................................... $      *
                                                                       ========
</TABLE>
- --------
* To be included by amendment

ITEM 14. INDEMNIFICATION OF DIRECTORS AND OFFICERS

Section 145 of the Delaware General Corporation Law authorizes a court to
award, or a corporation's board of directors to grant, indemnity to directors
and officers in terms sufficiently broad to permit such indemnification under
certain circumstances for liabilities (including reimbursement for expenses
incurred) arising under the Securities Act of 1933.

As permitted by the Delaware General Corporation Law, the registrant's Second
Amended and Restated Certificate of Incorporation includes a provision that
eliminates the personal liability of its directors for monetary damages for
breach of fiduciary duty as a director, except for liability (1) for any
breach of the director's duty of loyalty to the registrant or its
stockholders, (2) for acts or omissions not in good faith or that involve
intentional misconduct or a knowing violation of law, (3) under section 174 of
the Delaware General Corporation Law (regarding unlawful dividends and stock
purchases) or (4) for any transaction from which the director derived an
improper personal benefit.

As permitted by the Delaware General Corporation Law, the bylaws of the
registrant provide that (1) the registrant is required to indemnify its
directors and officers to the fullest extent permitted by the Delaware General
Corporation Law, subject to certain very limited exceptions, (2) the
registrant may indemnify its other employees and agents as set forth in the
Delaware General Corporation Law, (3) the registrant is required to advance
expenses, as incurred, to its directors and executive officers in connection
with a legal proceeding to the fullest extent permitted by the Delaware
General Corporation Law, subject to certain very limited exceptions and (4)
the rights conferred in the bylaws are not exclusive.

The registrant has entered into indemnification agreements with each of its
directors and executive officers to give such directors and officers
additional contractual assurances regarding the scope of the

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                                                                           II-1
<PAGE>

PART II

- -------------------------------------------------------------------------------
indemnification set forth in the registrant's Second Amended and Restated
Certificate of Incorporation and to provide additional procedural protections.
At present, there is no pending litigation or proceeding involving a director,
officer or employee of the registrant regarding which indemnification is
sought, nor is the registrant aware of any threatened litigation that may
result in claims for indemnification.

Reference is also made to Section    of the Underwriting Agreement, which
provides for the indemnification of officers, directors and controlling
persons of the registrant against certain liabilities. The indemnification
provision in the registrant's Second Amended and Restated Certificate of
Incorporation, bylaws and the indemnification agreements entered into between
the registrant and each of its directors and executive officers may be
sufficiently broad to permit indemnification of the registrant's directors and
executive officers for liabilities arising under the Securities Act of 1933.

The registrant has applied for liability insurance for its officers and
directors.

Reference is made to the following documents filed as exhibits to this
Registration Statement regarding relevant indemnification provisions described
above and elsewhere in this prospectus:

<TABLE>
<CAPTION>
                                                                       EXHIBIT
DOCUMENT                                                                NUMBER
- ------------------------------------------------------------------------------
<S>                                                                    <C>
Underwriting Agreement (draft dated       , 1999).....................    1.1
Form of Second Amended and Restated Certificate of Incorporation of
 Registrant...........................................................    3.2
Form of Restated Bylaws of Registrant.................................    3.4
Form of Indemnification Agreement.....................................  10.48
Form of Indemnification Agreement.....................................  10.49
</TABLE>

ITEM 15. RECENT SALES OF UNREGISTERED SECURITIES

The Registrant has sold and issued the following securities since January 1996
(such share numbers do not reflect the         -for-         reverse stock
split):

A. The Registrant from time to time has granted stock options to employees and
consultants in reliance upon exemption from registration pursuant to either
(1) Section 4(2) of the Securities Act of 1933 or (2) Rule 701 promulgated
under the Securities Act of 1933. The following table sets forth certain
information regarding such grants:

<TABLE>
<CAPTION>
                                                           NUMBER OF    EXERCISE
                                                              SHARES      PRICES
- --------------------------------------------------------------------------------
<S>                                                        <C>       <C>
January 1, 1996 to December 31, 1996......................   435,000       $0.25
January 1, 1997 to December 31, 1997......................   731,000       $0.25
January 1, 1998 to December 31, 1998...................... 1,268,500 $0.50-$1.10
January 1, 1999 to November 20, 1999...................... 1,020,500 $3.00-$3.30
</TABLE>

For additional information concerning these transactions, please see
"Management--Employee benefit plans" in the prospectus included in this
registration statement.

B. On December 23, 1996, we issued a warrant to purchase 70,000 shares of
Series A preferred stock to Comdisco, Inc. in consideration of entering into a
certain rental agreement.

C. On May 8, 1997, we issued 1,065,079 shares of Series C preferred stock and
warrants to purchase 106,503 shares of Series C preferred stock to various
venture capitalists and individuals for an aggregate consideration of
$3,354,999.

D. On January 12, 1998, we issued 3,508,252 shares of Series C preferred stock
to various venture capitalists for an aggregate consideration of $11,050,994.

E. On December 21, 1998, we issued 3,843,700 shares of Series D preferred
stock to various venture capitalists and individuals for an aggregate
consideration of $24,984,050.

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                                                                           II-2
<PAGE>

PART II

- -------------------------------------------------------------------------------

F. On February 28, 1999, we issued 900,303 shares of Series D preferred stock
to various venture capitalists and individuals for an aggregate consideration
of $5,851,970.

G. On March 30, 1999, we issued 968,760 shares of Series D preferred stock to
various venture capitalists, insiders, and individuals for an aggregate
consideration of $6,296,939.

H. From January 1, 1996 through November 19, 1999, we issued 1,969,750 shares
of common stock upon exercise of options for an aggregate consideration of $
1,322,467.

I. On March 23, 1999, we issued 6,349 shares of common stock to a consultant
for consideration of $20,000.

J. The above securities were offered and sold by the Registrant in reliance
upon exemptions from registration pursuant to either (1) Section 4(2) of the
Securities Act of 1933 as transactions not involving any public offering, or
(2) Rule 701 promulgated under the Securities Act of 1933. No underwriters
were involved in connection with the sales of securities referred to in this
Item 15.

ITEM 16. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES

<TABLE>
 <C>     <S>
 1.1*    Form of Underwriting Agreement.

 3.1++   Restated Certificate of Incorporation of the Registrant, as amended.

 3.2++   Form of Second Amended and Restated Certificate of Incorporation of
         the Registrant to become effective immediately prior to the Offering.

 3.3++   Bylaws of Registrant, as amended.

 3.4++   Form of Restated Bylaws to be in effect upon the completion of the
         Offering.

 4.1*    Specimen common stock certificate.

 5.1*    Opinion of Brobeck, Phleger & Harrison LLP.

 10.1+   Series B Convertible Preferred Stock Purchase Agreement, dated
         December 22, 1995.

 10.2+   Series C Convertible Preferred Stock Purchase Agreement, dated May 8,
         1997.
 10.3    Form of Warrant Agreement between the Registrant and holders of the
         Series C Preferred Stock warrants.

 10.4+   Series D Convertible Preferred Stock Purchase Agreement, dated
         December 21, 1998.

 10.5++  Amended and Restated Registration Rights Agreement, dated December 21,
         1998.

 10.6++  Amended and Restated Voting Agreement, dated December 21, 1998.

 10.7++  Amended and Restated Stock Restriction Agreement, dated December 21,
         1998.

 10.8++  Amended and Restated Amendment Agreement to the Series D Convertible
         Preferred Stock Purchase Agreement, dated March 1, 1999.

 10.9++  Warrant Agreement, dated December 23, 1996, between the Registrant and
         Comdisco, Inc.

 10.10   Form of Note Secured by Stock Pledge Agreement between the Registrant
         and the individuals listed on Schedule A thereto.

 10.11++ Form of Stock Pledge Agreement between the Registrant and the
         individuals listed on Schedule A thereto.

 10.12   Investment Contract, dated May 18, 1995, between the Registrant's
         subsidiary and TBG.
 10.13   Cooperation Agreement, dated May 1995, between the Registrant and TBG.
 10.14   Investment Contract, dated December 14, 1995, between the Registrant's
         subsidiary and TBG.

</TABLE>


- -------------------------------------------------------------------------------
                                                                           II-3
<PAGE>

PART II

- --------------------------------------------------------------------------------

<TABLE>
 <C>     <S>
 10.15   Cooperation Agreement, dated December 14, 1995, between the Registrant
         and TBG.

 10.16   Investment Contract, dated September 22, 1997, between the
         Registrant's subsidiary and TBG.

 10.17*  Cooperation Agreement, dated October 7, 1997, between the Registrant
         and TBG.

 10.18++ Security Agreement, dated April 29, 1999, between the Registrant and
         Union Bank of California.

 10.19++ Promissory Note, dated April 29, 1999, between the Registrant and
         Union Bank of California.

 10.20++ Business Loan Agreement, dated May 25, 1999, between the Registrant
         and Union Bank of California.

 10.21+  Beta Test Agreement, dated March 1, 1999, between the Registrant and
         GLE Medicon, GmbH.

 10.22+  Beta Test Agreement, dated April 21, 1999, between the Registrant and
         Universitat Munster.

 10.23+  Beta Test Agreement, dated July 15, 1999, between the Registrant and
         Genzyme Corporation.

 10.24+  Sponsored Research Agreement, dated September 15, 1994, between the
         Registrant and the Trustees of Boston University extended by Letter
         Agreements dated February 5, 1997 and September 6, 1998.

 10.25+  Patent and Know-How License Agreement, dated June 1, 1996, between the
         Registrant and the Trustees of Boston University.

 10.26+  License Agreement, dated July 3, 1997 between the Registrant and Johns
         Hopkins University.

 10.27+  Agreement, dated July 8, 1997, between the Registrant's subsidiary and
         Dr. Bertram Muller-Myhsok.

 10.28+  Letter Agreement, dated October 8, 1997, between the Registrant and
         Community Technology Fund, Office of Technology Transfer of Community
         Technology Fund and Center for Advanced Biotechnology (BU).

 10.29+  Collaboration Agreement, dated November 24, 1997, between the
         Registrant and Bruker-Franzen Analytik, GmbH.

 10.30+  Contractual Agreement, dated October 1, 1998, between the Registrant
         and GeSIM.

 10.31+  License Agreement, dated January 14, 1999, and Addendum to License
         Agreement and Patent Assignment, dated September 29, 1999, between the
         Registrant and Franz Hillenkamp.

 10.32+  Supply Agreement, dated April 1, 1999, between the Registrant and
         Tactical Fabs, Inc.

 10.33+  OEM Supply and License Agreement, dated June 15, 1999, between the
         Registrant and PerSeptive Biosystems, Inc.

 10.34+  Specific Cooperative Research Agreement No. 58-5438-9-120, dated June
         15, 1999, between the Registrant and US Department of Agriculture (US
         Meat Animal Research Center).

 10.35+  OEM Supply Agreement, dated June 24, 1999, between the Registrant and
         Beckman Coulter.

 10.36+  Cooperative Research and Development Agreement, dated September 17,
         1999, between the Registrant and Public Health Service.

 10.37++ Employment Agreement, dated July 1, 1997, between the Registrant and
         Hubert Koster.

 10.38   Form of Employment Agreement between the Registrant and the employees
         listed on Schedule A thereto.

</TABLE>


- --------------------------------------------------------------------------------
                                                                            II-4
<PAGE>

PART II

- -------------------------------------------------------------------------------

<TABLE>
 <C>     <S>
 10.39+  Consulting Services Agreement, dated October 4, 1996, between the
         Registrant and Franz Hillenkamp.

 10.40+  Consulting Services Agreement, dated January 30, 1997, between the
         Registrant and Peter Roepstorff.

 10.41+  Consulting Services Agreement, dated February 17, 1997, between the
         Registrant and Ulf B. Gobel.

 10.42+  Consulting Services Agreement, dated March 1, 1999, between the
         Registrant and John Cashman.

 10.43+  Consulting Services Agreement, dated March 1, 1999, between the
         Registrant and Lindsay Farrer.

 10.44++ Standard Industrial Gross Lease, dated December 12, 1996, between
         Registrant and Sorrento Business Complex, L.P., as amended.

 10.45   Master Equipment Lease Agreement No. 0135 and Letter extending the
         equipment lease, dated October 22, 1998, between Registrant and
         Phoenix Leasing Incorporated, as amended.

 10.46   Standard Form Commercial Lease, dated June 24, 1999, between
         Registrant and Cummings Properties, LLC, as amended.

 10.47*  Agreement for office space in Hamburg, dated May 1996, between the
         Registrant and Fiszman-Steinriede, GbR, as amended.

 10.48++ Form of Indemnification Agreement between the Registrant and each of
         its directors.

 10.49++ Form of Indemnification Agreement between the Registrant and each of
         its officers.

 10.50++ 1994 Stock Plan.

 10.51*  1994 Stock Plan Form of Non-Qualified Stock Option Grant.

 10.52*  1994 Stock Plan Form of Incentive Stock Option Grant.

 10.53*  1994 Stock Plan Form of Stock Restriction Agreement.

 10.54++ 1998 Stock Option/Stock Issuance Plan.

 10.55++ 1998 Stock Option/Stock Issuance Plan Form of Notice of Grant of Stock
         Option.

 10.56++ 1998 Stock Option/Stock Issuance Plan Form of Stock Option Agreement.

 10.57++ 1998 Stock Option/Stock Issuance Plan Form of Stock Purchase
         Agreement.

 10.58   1998 Stock Option/Stock Issuance Plan Form of Stock Issuance
         Agreement.

 10.59*  1999 Stock Incentive Plan.

 10.60*  1999 Employee Stock Purchase Plan.

 23.1++  Consent of Ernst & Young LLP, Independent Auditors.

 23.2*   Consent of Brobeck, Phleger & Harrison LLP (included in Exhibit 5.1).

 24.1++  Powers of Attorney (See Signature Page on Page II-6).

 27.1++  Financial Data Schedule.
</TABLE>
- --------
*  To be filed by amendment.
+  Certain confidential portions of this Exhibit were omitted by means of
   redacting a portion of the text (the "Mark"). This Exhibit has been filed
   separately with the Secretary of the Commission without the Mark pursuant
   to the Company's Application Requesting Confidential Treatment under Rule
   406 under the Securities Act.

++ Previously filed.

- -------------------------------------------------------------------------------
                                                                           II-5
<PAGE>

PART II

- -------------------------------------------------------------------------------

  (b) Financial Statement Schedules.

All financial statement schedules for which provision is made in the
applicable accounting regulations of the Securities and Exchange Commission
have been omitted because they are not required under the related instructions
or are inapplicable as the information has been provided in the consolidated
financial statements or related notes thereto.

ITEM 17. UNDERTAKINGS

The undersigned Registrant hereby undertakes to provide to the underwriter at
the closing specified in the Underwriting Agreement, certificates in such
denominations and registered in such names as required by the underwriter to
permit prompt delivery to each purchaser.

Insofar as indemnification for liabilities arising under the Securities Act of
1933 may be permitted to directors, officers and controlling persons of the
Registrant pursuant to the foregoing provisions, or otherwise, the Registrant
has been advised that in the opinion of the SEC such indemnification is
against public policy as expressed in the Act, and is, therefore,
unenforceable. In the event that a claim for indemnification against such
liabilities (other than the payment by the Registrant of expenses incurred or
paid by a director, officer or controlling person of the Registrant in the
successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities
being registered, the Registrant will, unless in the opinion of counsel the
matter has been settled by controlling precedent, submit to a court of
appropriate jurisdiction the question whether such indemnification by it is
against public policy as expressed in the Act and will be governed by the
final adjudication of such issue.

The undersigned Registrant hereby undertakes that:

(1) For purposes of determining any liability under the Securities Act of 1933
the information omitted from the form of prospectus filed as part of this
registration statement in reliance upon Rule 430A and contained in a form of
prospectus filed by the registrant pursuant to Rule 424(b)(1) or (4) or 497(h)
under the Securities Act of 1933 shall be deemed to be part of this
registration statement as of the time it was declared effective.

(2) For the purpose of determining any liability under the Securities Act of
1933 each post-effective amendment that contains a form of prospectus shall be
deemed to be a new registration statement relating to the securities offered
therein, and the offering of such securities at that time shall be deemed to
be the initial bona fide offering thereof.

- -------------------------------------------------------------------------------
                                                                           II-6
<PAGE>

PART II

- -------------------------------------------------------------------------------
Signatures

Pursuant to the requirements of the Securities Act of 1933 the Registrant has
duly caused this Registration Statement to be signed on its behalf by the
undersigned, thereunto duly authorized in San Diego, California, on this 7th
day of December 1999.

                                          SEQUENOM, INC.

                                               /s/ Stephen Zaniboni
                                          By: _________________________________

                                             Name: Stephen Zaniboni

                                             Title: Senior Vice President and
                                                 Chief Financial Officer

Pursuant to the requirements of the Securities Act of 1933 this Registration
Statement has been signed by the following persons in the capacities indicated
on December 7, 1999:

<TABLE>
<CAPTION>
             SIGNATURE                         TITLE(S)                        DATE
- -----------------------------------------------------------------------------------

<S>                                  <C>                           <C>
       */s/ Hubert Koster            President and Chief           December 7, 1999
____________________________________  Executive Officer
           HUBERT KOSTER              (principal executive
                                      officer) and Director

      /s/ Stephen Zaniboni           Senior Vice President and     December 7, 1999
____________________________________  Chief Financial Officer
          STEPHEN ZANIBONI            (principal financial and
                                      accounting officer)

     */s/ Helmut Schuhsler           Director                      December 7, 1999
____________________________________
          HELMUT SCHUHSLER

    */s/ Ernst-Gunter Afting         Director                      December 7, 1999
____________________________________
        ERNST-GUNTER AFTING
        */s/ John Lucas              Director                      December 7, 1999
____________________________________
             JOHN LUCAS

      */s/ Peter Reinisch            Director                      December 7, 1999
____________________________________
           PETER REINISCH
 *By:  /s/ Stephen Zaniboni
           STEPHEN ZANIBONI
           ATTORNEY-IN-FACT
</TABLE>

- -------------------------------------------------------------------------------
                                                                           II-7
<PAGE>


- --------------------------------------------------------------------------------
Index to exhibits


<TABLE>
 <C>     <S>
 1.1*    Form of Underwriting Agreement.

 3.1++   Restated Certificate of Incorporation of the Registrant, as amended.

 3.2++   Form of Second Amended and Restated Certificate of Incorporation of
         the Registrant to become effective immediately prior to the Offering.

 3.3++   Bylaws of Registrant, as amended.

 3.4++   Form of Restated Bylaws to be in effect upon the completion of the
         Offering.

 4.1*    Specimen common stock certificate.

 5.1*    Opinion of Brobeck, Phleger & Harrison LLP.

 10.1+   Series B Convertible Preferred Stock Purchase Agreement, dated
         December 22, 1995.

 10.2+   Series C Convertible Preferred Stock Purchase Agreement, dated May 8,
         1997.
 10.3    Form of Warrant Agreement between the Registrant and holders of the
         Series C Preferred Stock warrants.

 10.4+   Series D Convertible Preferred Stock Purchase Agreement, dated
         December 21, 1998.

 10.5++  Amended and Restated Registration Rights Agreement, dated December 21,
         1998.

 10.6++  Amended and Restated Voting Agreement, dated December 21, 1998.

 10.7++  Amended and Restated Stock Restriction Agreement, dated December 21,
         1998.

 10.8++  Amended and Restated Amendment Agreement to the Series D Convertible
         Preferred Stock Purchase Agreement, dated March 1, 1999.

 10.9++  Warrant Agreement, dated December 23, 1996, between the Registrant and
         Comdisco, Inc.

 10.10   Form of Note Secured by Stock Pledge Agreement between the Registrant
         and the individuals listed on Schedule A thereto.

 10.11++ Form of Stock Pledge Agreement between the Registrant and the
         individuals listed on Schedule A thereto.

 10.12   Investment Contract, dated May 18, 1995, between the Registrant's
         subsidiary and TBG.
 10.13   Cooperation Agreement, dated May 1995, between the Registrant and TBG.
 10.14   Investment Contract, dated December 14, 1995, between the Registrant's
         subsidiary and TBG.

 10.15   Cooperation Agreement, dated December 14, 1995, between the Registrant
         and TBG.

 10.16   Investment Contract, dated September 22, 1997, between the
         Registrant's subsidiary and TBG.

 10.17*  Cooperation Agreement, dated October 7, 1997, between the Registrant
         and TBG.

 10.18++ Security Agreement, dated April 29, 1999, between the Registrant and
         Union Bank of California.

 10.19++ Promissory Note, dated April 29, 1999, between the Registrant and
         Union Bank of California.

 10.20++ Business Loan Agreement, dated May 25, 1999, between the Registrant
         and Union Bank of California.

 10.21+  Beta Test Agreement, dated March 1, 1999, between the Registrant and
         GLE Medicon, GmbH.

 10.22+  Beta Test Agreement, dated April 21, 1999, between the Registrant and
         Universitat Munster.
</TABLE>

- --------------------------------------------------------------------------------
<PAGE>

INDEX TO EXHIBITS

- --------------------------------------------------------------------------------

<TABLE>
 <C>     <S>
 10.23+  Beta Test Agreement, dated July 15, 1999, between the Registrant and
         Genzyme Corporation.

 10.24+  Sponsored Research Agreement, dated September 15, 1994, between the
         Registrant and the Trustees of Boston University extended by Letter
         Agreements dated February 5, 1997 and September 6, 1998.

 10.25+  Patent and Know-How License Agreement, dated June 1, 1996, between the
         Registrant and the Trustees of Boston University.

 10.26+  License Agreement, dated July 3, 1997 between the Registrant and Johns
         Hopkins University.

 10.27+  Agreement, dated July 8, 1997, between the Registrant's subsidiary and
         Dr. Bertram Muller-Myhsok.

 10.28+  Letter Agreement, dated October 8, 1997, between the Registrant and
         Community Technology Fund, Office of Technology Transfer of Community
         Technology Fund and Center for Advanced Biotechnology (BU).

 10.29+  Collaboration Agreement, dated November 24, 1997, between the
         Registrant and Bruker-Franzen Analytik, GmbH.

 10.30+  Contractual Agreement, dated October 1, 1998, between the Registrant
         and GeSIM.

 10.31+  License Agreement, dated January 14, 1999, and Addendum to License
         Agreement and Patent Assignment, dated September 29, 1999, between the
         Registrant and Franz Hillenkamp.

 10.32+  Supply Agreement, dated April 1, 1999, between the Registrant and
         Tactical Fabs, Inc.

 10.33+  OEM Supply and License Agreement, dated June 15, 1999, between the
         Registrant and PerSeptive Biosystems, Inc.

 10.34+  Specific Cooperative Research Agreement No. 58-5438-9-120, dated June
         15, 1999, between the Registrant and US Department of Agriculture (US
         Meat Animal Research Center).

 10.35+  OEM Supply Agreement, dated June 24, 1999, between the Registrant and
         Beckman Coulter.

 10.36+  Cooperative Research and Development Agreement, dated September 17,
         1999, between the Registrant and Public Health Service.

 10.37++ Employment Agreement, dated July 1, 1997, between the Registrant and
         Hubert Koster.

 10.38   Form of Employment Agreement between the Registrant and the employees
         listed on Schedule A thereto.

 10.39+  Consulting Services Agreement, dated October 4, 1996, between the
         Registrant and Franz Hillenkamp.

 10.40+  Consulting Services Agreement, dated January 30, 1997, between the
         Registrant and Peter Roepstorff.

 10.41+  Consulting Services Agreement, dated February 17, 1997, between the
         Registrant and Ulf B. Gobel.

 10.42+  Consulting Services Agreement, dated March 1, 1999, between the
         Registrant and John Cashman.

 10.43+  Consulting Services Agreement, dated March 1, 1999, between the
         Registrant and Lindsay Farrer.

 10.44++ Standard Industrial Gross Lease, dated December 12, 1996, between
         Registrant and Sorrento Business Complex, L.P., as amended.

 10.45   Master Equipment Lease Agreement No. 0135 and Letter extending the
         equipment lease, dated October 22, 1998, between Registrant and
         Phoenix Leasing Incorporated, as amended.

</TABLE>

- --------------------------------------------------------------------------------
<PAGE>

INDEX TO EXHIBITS

- -------------------------------------------------------------------------------

<TABLE>
 <C>     <S>
 10.46   Standard Form Commercial Lease, dated June 24, 1999, between
         Registrant and Cummings Properties, LLC, as amended.

 10.47*  Agreement for office space in Hamburg, dated May 1996, between the
         Registrant and Fiszman-Steinriede, GbR, as amended.

 10.48++ Form of Indemnification Agreement between the Registrant and each of
         its directors.

 10.49++ Form of Indemnification Agreement between the Registrant and each of
         its officers.

 10.50++ 1994 Stock Plan.

 10.51*  1994 Stock Plan Form of Non-Qualified Stock Option Grant.

 10.52*  1994 Stock Plan Form of Incentive Stock Option Grant.

 10.53*  1994 Stock Plan Form of Stock Restriction Agreement.

 10.54++ 1998 Stock Option/Stock Issuance Plan.

 10.55++ 1998 Stock Option/Stock Issuance Plan Form of Notice of Grant of Stock
         Option.

 10.56++ 1998 Stock Option/Stock Issuance Plan Form of Stock Option Agreement.

 10.57++ 1998 Stock Option/Stock Issuance Plan Form of Stock Purchase
         Agreement.

 10.58   1998 Stock Option/Stock Issuance Plan Form of Stock Issuance
         Agreement.

 10.59*  1999 Stock Incentive Plan.

 10.60*  1999 Employee Stock Purchase Plan.

 23.1++  Consent of Ernst & Young LLP, Independent Auditors.

 23.2*   Consent of Brobeck, Phleger & Harrison LLP (included in Exhibit 5.1).

 24.1++  Powers of Attorney (See Signature Page on Page II-6).

 27.1++  Financial Data Schedule.
</TABLE>
- --------
*  To be filed by amendment.
+  Certain confidential portions of this Exhibit were omitted by means of
   redacting a portion of the text (the "Mark"). This Exhibit has been filed
   separately with the Secretary of the Commission without the Mark pursuant
   to the Company's Application Requesting Confidential Treatment under Rule
   406 under the Securities Act.

++ Previously filed.

- -------------------------------------------------------------------------------

<PAGE>

                                                                    EXHIBIT 10.1

                        SERIES B CONVERTIBLE PREFERRED
                           STOCK PURCHASE AGREEMENT


     THIS AGREEMENT made as of the 22nd day of December, 1995, by and among
Sequenom, Inc., a Delaware corporation (the "Corporation"); the several
investors named on the Schedule of Investors attached hereto (individually, an
"Initial Investor", and collectively, the "Initial Investors"); such additional
investors as may be identified on such addenda to the Schedule of Investors as
may be agreed upon by the Corporation and such additional investors in
accordance with the terms of this Agreement (individually, an "Additional
Investor", and collectively, the "Additional Investors") (the Initial Investors
and the Additional Investors being hereinafter sometimes referred to
individually as an "Investor" and collectively as the "Investors"); and, solely
for purposes of Section 8.1 hereof, Hubert Koster, Nola E. Masterson, and Robert
E. Patterson (individually a "Founder" and collectively the "Founders).

     WHEREAS, the Investors wish to purchase from the Corporation, and the
Corporation wishes to sell to the Investors, up to an aggregate of 3,333,333
shares of the Corporation's Series B Convertible Preferred Stock, par value
$.001 per share (the "Series B Preferred");

     WHEREAS, pursuant to that certain Stock Purchase Agreement dated May 26,
1994 (the "Original Purchase Agreement") the Corporation granted certain rights
of first refusal to certain of the Initial Investors and the Founders, and the
Corporation, such Initial Investors and the Founders now desire to replace such
rights of first refusal in the Original Purchase Agreement with the rights of
first refusal set forth in Section 8.1 hereof;

     NOW, THEREFORE, in consideration of the premises and the mutual covenants
and agreements herein contained, the parties hereby agree as follows:

     SECTION 1.  Amendment of Certificate of Incorporation.  Immediately prior
     ---------   -----------------------------------------
to the execution and delivery of this Agreement, the Corporation filed with the
Secretary of State of Delaware a Certificate of Amendment (the "Certificate of
Amendment"), a copy of which is attached hereto as Exhibit 1, to its Certificate
of Incorporation (the Certificate of Incorporation of the Corporation, as
amended by the Certificate of Amendment and in effect on the date hereof being
hereinafter referred to as the "Certificate of Incorporation"), for the purpose
of increasing and amending the authorized capital stock of the Corporation and
setting forth the designations and the powers, preferences and rights, and the
qualifications, limitations and restrictions thereof, granted to or imposed upon
the capital stock of the Corporation or the holders thereof.

     SECTION 2.  Purchase and Sale of the Series B Preferred.
     ---------   -------------------------------------------

          2.1  Initial Shares.  Subject to the terms and conditions of this
               --------------
Agreement, at the Initial Closing (as defined in Section 3.1), the Corporation
agrees to issue and sell an aggregate of 2,333,333 shares of Series B Preferred
(the "Initial Shares") to the Initial Investors, and each Initial Investor,
acting severally and not jointly, hereby agrees to purchase from the Corporation
the number of Initial Shares set forth opposite the name of such Initial
Investor on
<PAGE>

the Schedule of Investors, at the purchase price of $1.50 per share and at the
aggregate purchase price set forth opposite the name of such Initial Investor on
the Schedule of Investors.

          2.2  Additional Shares.  Subject to the terms and conditions of this
               -----------------
Agreement, from time to time after the Initial Closing, but on or before January
31, 1996, the Corporation hereby agrees to issue and sell up to an aggregate of
1,000,000 shares of Series B Preferred (the "Additional Shares") to one or more
Additional Investors who enter into this Agreement by executing one or more
counterparts hereof.  By executing such a counterpart, each such Additional
Investor shall agree to purchase that number of Additional Shares as may be set
forth opposite its name on such addenda to the Schedule of Investors which may
be agreed upon between the Corporation and each such Additional Investor, at the
purchase price of $1.50 per share and at the aggregate purchase price set forth
opposite such Additional Investor's name on such addenda.  Each such addendum
shall be executed by the Corporation and each such Additional Investor, a copy
of each such addendum shall be delivered to each Investor, and each such
addendum shall be deemed a part of this Agreement ab initio.  Initial Investors
                                                  -- ------
may become Additional Investors.

     The Initial Shares and the Additional Shares are referred to collectively
hereinafter as the "Shares".

     SECTION 3.  Closings.
     ---------   --------

          3.1  Initial Closing.  The closing of the sale and purchase of the
               ---------------
Initial Shares (the "Initial Closing") shall take place simultaneously with the
execution of this Agreement at the offices of Foley, Hoag & Eliot, One Post
Office Square, Boston, Massachusetts 02109, on December 22, 1995 (the "Initial
Closing Date"), or at such other location, date and time as may be agreed upon
between the Initial Investors and the Corporation.  At the Initial Closing, the
Corporation shall issue and deliver to each Initial Investor a certificate or
certificates registered in the name of such Initial Investor, representing the
Initial Shares being purchased by it at the Initial Closing, against payment by
such Initial Investor to the Corporation of the purchase price therefor in the
form of (a) a check payable to the order of the Corporation, (b) a wire transfer
to the account of the Corporation, (c) cancellation of indebtedness of the
Corporation to such Investor or an affiliate of such Investor, (d) conversion of
convertible promissory notes issued by the Corporation to such Investor or an
affiliate of such Investor, or (e) any Combination of (a), (b), (c) and (d)
above.

          3.2  Additional Closings.  The closings of the sale and purchase of
               -------------------
the Additional Shares under this Agreement (the "Additional Closings") shall
take place at such time, date and place as are mutually agreeable to the
Corporation and any Additional Investor, but such Additional Closings, if any,
shall take place on or before January 31, 1996.  At the Additional Closings, the
Corporation shall issue and deliver to each Additional Investor a certificate or
certificates registered in the name of such Additional Investor, representing
the Additional Shares being purchased by it at the Additional Closing, against
payment by such Additional Investor to the Corporation of the purchase price
therefor in the form of (a) a check payable to the order of the Corporation, (b)
a wire transfer to the account of the Corporation, (c) cancellation of
indebtedness of the Corporation to such Additional Investor, (d) conversion of

                                      -2-
<PAGE>

convertible promissory notes issued by the Corporation to such Additional
Investor, or (e) any combination of (a), (b), (c) and (d) above.

     SECTION 4.  Representations and Warranties of the Corporation.  The
     ---------   -------------------------------------------------
Corporation hereby represents and warrants to the Investors as follows:

          4.1  Organization.  The Corporation is a corporation duly organized,
               ------------
validly existing and in good standing under the laws of the State of Delaware
and has all requisite corporate power and authority to own and lease its
properties, to carry on its business as presently conducted and as proposed to
be conducted and to carry out the transactions contemplated hereby. Except as
set forth in Exhibit 4.1, the Corporation is duly qualified as a foreign
             -----------
corporation and is in good standing in all such other jurisdictions (which
jurisdictions are listed in Exhibit 4.1) in which the conduct of its business or
                            -----------
its ownership or leasing of property requires such qualification and in which
the failure so to qualify or so to be in good standing would have a materially
adverse effect on the Corporation's operations or financial condition.  Exhibit
                                                                        -------
4.1 contains true, complete and accurate copies of the Certificate of
- ---
Incorporation and the By-Laws, as amended to date, of the Corporation (the
"ByLaws").

          4.2  Capitalization.  The entire authorized capital stock of the
               --------------
Corporation consists of:

          (a)  5,726,700 shares of Common Stock, par value $.001 per share (the
"Common Stock");

          (b)  1,650,000 shares of Series A Convertible Preferred Stock, par
value $.001 per share (the "Series A Preferred"); and

          (C)  3,376,666 shares of Series B Preferred.

     The number of shares of Common Stock and Series A Preferred that are issued
and outstanding or held as treasury shares as of the date hereof is as set forth
in Exhibit 4.2.  All issued and outstanding shares of Common Stock and Series A
   -----------
Preferred are validly issued, fully paid and nonassessable.  The number of
shares of Common Stock reserved for issuance upon the exercise of options
granted and to be granted, and upon conversion of the Series A Preferred and the
Series B Preferred, is as set forth in Exhibit 4.2.  Prior to the Initial
                                       -----------
Closing, no shares of Series B Preferred were issued or outstanding.
Immediately following the Initial Closing, 2,333,333 shares of Series B
Preferred (the "Initial Shares") will be issued and outstanding and held by the
Initial Investors, and 1,000,000 shares of Series B Preferred (the "Additional
Shares") will be reserved for issuance at the Additional Closings.

     Exhibit 4.2 contains a list of all holders of capital stock of the
     -----------
Corporation and options, warrants or rights to purchase such capital stock, in
each case including the number of shares of capital stock held by, or subject to
purchase pursuant to the exercise of any option, warrant or right held by, each
such holder.  Except as set forth in Exhibit 4.2, there are no outstanding
                                     -----------
shares of capital stock of the Corporation or warrants, options, agreements,
convertible securities or other commitments pursuant to which the Corporation is
or may become obligated to issue

                                      -3-
<PAGE>

any shares of its capital stock or other securities of the Corporation. Except
as set forth in Exhibit 4.2, the number of shares of capital stock, if any,
                -----------
reserved for issuance in connection with the securities described in the
immediately preceding sentence is not subject to adjustment by reason of the
issuance of the Shares or the Reserved Shares (as defined in Section 4.16).
Except as set forth in Exhibit 4.2, there are no preemptive or similar rights to
                       -----------
purchase or otherwise acquire shares of capital stock of the Corporation
pursuant to any provision of law, the Certificate of Incorporation or the By-
Laws or any agreement to which the Corporation is a party, or otherwise, and
except as set forth in the Voting Agreement described in Section 6.6 of this
Agreement, there is no agreement, restriction or encumbrance with respect to the
sale or voting of any shares of the Corporation's capital stock (whether
outstanding or issuable upon conversion or exercise of outstanding securities).

          4.3  Equity Investments.  Except as set forth on Exhibit 4.3, the
               ------------------                          -----------
Corporation does not currently have any subsidiaries nor currently own any
capital stock or other proprietary interest, directly or indirectly, in any
corporation, association, trust, partnership, joint venture or other entity.

          4.4  Financial Statements.  Attached as Exhibit 4.4A are the unaudited
               --------------------               ------------
balance sheet for the Corporation as of December 31, 1994, and the related
unaudited statement of income for the year ending December 31, 1994.  Attached
as Exhibit 4.4B are the unaudited balance sheet of the Corporation as of October
   ------------
31, 1995 (the "Balance Sheet"), and the related unaudited statement of income
for the ten-month period ended October 31, 1995. (October 31, 1995 is
hereinafter sometimes referred to as the "Balance Sheet Date.") The December 31,
1994 and October 31, 1995 financial statements are in accordance with the books
and records of the Corporation and present fairly the financial position and
results of operations of the Corporation as of the dates and for the periods
indicated.

          4.5  Absence of Undisclosed Liabilities.  Except as set forth in
               ----------------------------------
Exhibit 4.5 or as reflected in the Balance Sheet, at the Balance Sheet Date (a)
- -----------
the Corporation had no material liabilities of any nature (matured or unmatured,
fixed or contingent) of a type required by generally accepted accounting
principles to be disclosed on a balance sheet of the Corporation which were not
so disclosed; (b) all reserves established by the Corporation and set forth in
the Balance Sheet were adequate; and (c) there were no loss contingencies (as
such term is used in Statement of Financial Accounting Standards No. 5 issued by
the Financial Accounting Standards Board in March 1975) which were not
adequately disclosed in the Balance Sheet as required by such Statement No. 5.

          4.6  Absence of Changes.  Except as set forth in Exhibit 4.6, since
               ------------------                          -----------
the Balance Sheet Date there has not been (a) any material adverse change in the
financial condition, results of operations, assets, liabilities, business or
prospects of the Corporation, (b) any material asset or property of the
Corporation made subject to a lien of any kind, (c) any waiver of any valuable
right of the Corporation, or the cancellation of any debt or claim held by the
Corporation, (d) any payment of dividends on, or other distribution with respect
to, or any direct or indirect redemption or acquisition of, any shares of the
capital stock of the Corporation, or any agreement or commitment therefor, (e)
any mortgage, pledge, sale, assignment or transfer of any tangible or intangible
assets of the Corporation, except in the ordinary course of business, (f) any
loan by the

                                      -4-
<PAGE>

Corporation to, or any loan to the Corporation from, any officer, director,
employee or stockholder of the Corporation, or any agreement or commitment
therefor, (g) any damage, destruction or loss (whether or not covered by
insurance) materially and adversely affecting the assets, property or business
of the Corporation, or (h) any change in the accounting methods or practices
followed by the Corporation.

          4.7  Encumbrances.  Except as set forth in Exhibit 4.7, the
               ------------                          -----------
Corporation has good title to all of its property and assets, real, personal or
mixed, tangible or intangible, free and clear of all liens, security interests,
charges and other encumbrances of any kind.

          4.8  Intellectual Property Rights.  Except in each case as set forth
               ----------------------------
in Exhibit 4.8:
   -----------

          (a)  the Corporation owns or has the right to use all Intellectual
Property Rights (as hereinafter defined) necessary or required for the conduct
of its business as presently conducted or as proposed to be conducted, which
Intellectual Property Rights are identified in said Exhibit 4.8;
                                                    -----------

          (b)  to the Corporation's knowledge, no royalties or other amounts are
payable by the Corporation to other persons by reason of the ownership or use of
said Intellectual Property Rights; and

          (c)  to the Corporation's knowledge, no product marketed or sold or
proposed to be marketed or sold by the Corporation violates or will violate any
license or infringes any Intellectual Property Rights of another, nor has the
Corporation received any notice that any of such Intellectual Property Rights or
the operation or proposed operation of the Corporation's business conflicts or
will conflict with the rights of others.

As used herein, the term "Intellectual Property Rights" means all patents,
trademarks, service marks, trade names, copyrights, inventions, trade secrets,
proprietary processes and formulae, applications for patents, trademarks,
service marks and copyrights, and other industrial and intellectual property
rights.

          Dr. Hubert Koster has entered into an agreement with the Company
relating to protection of proprietary information and invention assignment in
the form included in Exhibit 4.8.
                     -----------

          4.9  Litigation.  There is no action, suit, claim, proceeding or
               ----------
investigation, at law, in equity or otherwise, or by or before any governmental
instrumentality or other agency, now pending, or, to the Corporation's
knowledge, threatened against the Corporation.

          4.10 No Defaults.  The Corporation is not in violation or breach of,
               -----------
or in default under, any provision of (a) the Certificate of Incorporation or
the By-Laws or (b) except where any such violation, breach or default would not
have a material adverse effect on the Corporation, any note, indenture,
mortgage, lease, contract, purchase order or other instrument, document or
agreement to which the Corporation is a party or by which it or any of its
property

                                      -5-
<PAGE>

is bound or affected or any ruling, writ, injunction, order, judgment or decree
of any court, administrative agency or other governmental body. To the
Corporation's knowledge, there exists no condition, event or act which after
notice, lapse of time, or both, would constitute a violation or breach of, or a
default under, any of the foregoing.

          4.11  Employment of Officers, Employees and Consultants.  No third
                -------------------------------------------------
party may assert any valid claim against the Corporation, any Investor, or any
Designated Person (as hereinafter defined) with respect to (a) the continued
employment by or association with the Corporation of any of the present officers
or employees of, or consultants to, the Corporation (collectively, the
"Designated Persons"), or (b) the use or disclosure by the Corporation or any
Designated Person of any information which the Corporation or any Designated
Person would be prohibited from using or disclosing under any prior agreements
or arrangements or under any laws, including, without limitation, laws
applicable to unfair competition, trade secrets or proprietary information.

          4.12  Taxes.  The Corporation has filed all Federal, state, local and
                -----
foreign tax returns which are required to be filed by it and all such returns
are true and correct.  The Corporation has paid all taxes pursuant to such
returns or pursuant to any assessments received by it or which it is obligated
to withhold from amounts owing to any employee, creditor or third party, except,
in each case, for those which are not yet due and payable pursuant to such
returns.

          4.13  Agreements.  Except as set forth in Exhibit 4.13, the
                ----------                          ------------
Corporation is not a party to any written or oral (a) contract with any labor
union; (b) contract for the future purchase of fixed assets or for the future
purchase of materials, supplies or equipment in excess of normal operating
requirements; (c) contract for the employment of any officer, individual
employee or other person or any contract with any person on a consulting basis;
(d) bonus, pension, profit-sharing, retirement, stock purchase, stock option,
hospitalization, medical insurance or similar plan, contract or understanding in
effect with respect to employees or any of them or the employees of others; (e)
agreement or indenture relating to the borrowing of money or to the mortgaging,
pledging or otherwise placing a lien on any assets of the Corporation; (f)
guaranty of any obligation for borrowed money or otherwise; (g) lease or
agreement under which the Corporation is lessee of or holds or operates any
property, real or personal, owned by any other party; (h) lease or agreement
under which the Corporation is lessor of or permits any third party to hold or
operate any property, real or personal, owned or controlled by the Corporation;
(i) license or lease agreement with respect to any Intellectual Property Rights;
(j) agreement or other commitment for capital expenditures in excess of $25,000;
or (k) contract, agreement or commitment under which the Corporation is
obligated to pay any broker's fees, finder's fees or any such similar fees, to
any third party.  Except as set forth in Exhibit 4.13, the Corporation is not
                                         ------------
engaged in any negotiations which could lead to any such contract, agreement,
arrangement, understanding or commitment.  The Corporation has furnished to the
Investors true and correct copies of all such agreements, and other documents
requested by the Investors or its authorized representatives.

          4.14  Compliance.  The Corporation has complied in all material
                ----------
respects with all Federal, state, local or foreign laws applicable to its
business.  The Corporation has all Federal, state, local and foreign
governmental licenses, registrations and permits material to or

                                      -6-
<PAGE>

necessary for the conduct of its business, and such licenses, registrations and
permits are in full force and effect and there have been no violations in any
material respect of any such licenses, registrations or permits. No proceeding
is pending or, to the Corporation's knowledge, threatened, to revoke or limit
any thereof.

          4.15  Insurance.  Exhibit 4.15 sets forth each insurance policy
                ---------   ------------
(specifying the insurer, the amount of coverage, the type of insurance, the
policy number, the expiration date, the annual premium and any pending claims
thereunder) maintained by the Corporation on its properties, assets, business or
personnel.  The insurance maintained by the Corporation on its properties,
assets, business and personnel is in amounts deemed adequate by the Corporation,
is in accordance with the standards of the industry in which the Corporation
operates, and is under policies currently in effect and issued by insurers of
recognized responsibility.

          4.16  Authorization of this Agreement.  The execution, delivery and
                -------------------------------
performance by the Corporation of this Agreement, the Registration Rights
Agreement of even date herewith by and among the Corporation and the Investors
in the form of Exhibit 4.16A (the "Registration Rights Agreement") and the
               -------------
Voting Agreement of even date herewith by and among the parties hereto in the
form of Exhibit 4.16B (the "Voting Agreement"; this Agreement, the Registration
        -------------
Rights Agreement and Voting Agreement are herewith referred to collectively as
the "Transaction Documents") have been duly authorized by all requisite
corporate action.  The Transaction Documents have been duly executed and
delivered on behalf of the Corporation and constitute the valid and binding
obligations of the Corporation, enforceable in accordance with their respective
terms.  The execution, delivery and performance of the Transaction Documents,
the issuance, sale and delivery of the Shares and the shares of Common Stock
issuable upon conversion of the Shares (the "Reserved Shares"), and compliance
with the provisions hereof and thereof by the Corporation, do not and will not,
with or without the passage of time or the giving of notice or both, (a) violate
any provision of law, statute, rule or regulation or any ruling, writ,
injunction, order, judgment or decree of any court, administrative agency or
other governmental body or (b) conflict with or result in any breach of any of
the terms, conditions or provisions of, or constitute a default (or give rise to
any right of termination, cancellation or acceleration) under, or result in the
creation of any lien, security interest, charge or encumbrance upon any of the
properties or assets of the Corporation under, the Certificate of Incorporation
or By-Laws or any note, indenture, mortgage, lease, contract, purchase order or
other instrument, document or agreement to which the Corporation is a party or
by which it or any of its property is bound or affected.

          4.17  Authorization of Shares.  The issuance, sale and delivery
                -----------------------
hereunder by the Corporation of the Shares have been duly authorized by all
requisite corporate action, and when so issued, sold and delivered, the Shares
will be validly issued and outstanding, fully paid and nonassessable, and not
subject to preemptive or any other similar rights of the stockholders of the
Corporation or others.

          4.18  Authorization of Reserved Shares.  The issuance, sale and
                --------------------------------
delivery by the Corporation of the Reserved Shares have been duly authorized by
all requisite corporate action of the Corporation, and the Reserved Shares have
been duly reserved for issuance upon conversion of all or any of the Shares, and
when so issued and delivered upon conversion of any

                                      -7-
<PAGE>

of the Shares, the Reserved Shares will be validly issued and outstanding, fully
paid and nonassessable, and not subject to preemptive or any other similar
rights of the stockholders of the Corporation or others.

          4.19  Related Transactions.  Except as set forth in Exhibit 4.19, no
                --------------------                          ------------
director, officer or employee of the Corporation nor any "associate" (as defined
in the rules and regulations promulgated under the Securities Exchange Act of
1934 (the "Exchange Act")) of any such person is indebted to the Corporation,
nor is the Corporation indebted (or committed to make loans or extend or
guarantee credit) to any such person, nor is any such person a party to any
transaction (other than as an employee or consultant) with the Corporation
providing for the furnishing of services by, or rental of real or personal
property from, or otherwise requiring cash payments to, any such person.

          4.20  No Governmental Consent or Approval Required.  Except as set
                --------------------------------------------
forth in Exhibit 4.20, no authorization, consent, approval or other order of,
         ------------
declaration to, or filing with, any governmental agency or body is required to
be made or obtained by the Corporation for or in connection with the valid and
lawful authorization, execution and delivery by the Corporation of the
Transaction Documents, for or in connection with the valid and lawful
authorization, issuance, sale and delivery of the Shares or for or in connection
with the valid and lawful authorization, reservation, issuance, sale and
delivery of the Reserved Shares, except such exemptive filings as are required
to be made under applicable securities laws and have been and shall be made on a
timely basis.

          4.21  Registration Rights.  Except as contemplated by the Registration
                -------------------
Rights Agreement, no person has any right to cause the Corporation to effect the
registration under the Securities Act of 1933, as amended (the "Securities
Act"), of any shares of Common Stock, Series A Preferred or any other securities
of the Corporation.

          4.22  Exemptions from Securities Laws.  Subject to the accuracy of the
                -------------------------------
representations and warranties of the Investors set forth in Section 5 hereof,
the provisions of Section 5 of the Securities Act are inapplicable to the
offering, issuance, sale and delivery of the Shares and the Reserved Shares, and
no consent, approval, qualification or registration or filing under any state
securities laws is required in connection therewith, except such exemptive
filings as are required to be made under applicable securities laws and have
been and shall be made on a timely basis.

          4.23  Commitments from German Government.  Exhibit 4.23 accurately
                ----------------------------------   ------------
describes certain commitments from certain German governmental authorities made
with respect to the Corporation and its subsidiary Sequenom Instruments GmbH.

     SECTION 5.  Representations and Warranties of the Investors.  Each
     ---------   -----------------------------------------------
Investor, severally and not jointly, represents and warrants to the Corporation
as follows:

          5.1   Organization. Such Investor is an entity duly organized, validly
                ------------
existing and in good standing under the laws of the jurisdiction of its
organization, with all requisite

                                      -8-
<PAGE>

power and authority to own and lease its properties, to carry on its business,
and to carry out the transactions contemplated hereby.

          5.2  Purchase for Investment.  Such Investor is acquiring the Shares,
               -----------------------
and, in the event such Investor should acquire Reserved Shares upon conversion
of the Shares, such Investor will be acquiring the Reserved Shares, for its own
account, for investment and not for, with a view to, or in connection with, any
distribution or public offering thereof within the meaning of the Securities
Act.

          5.3  Unregistered Securities; Legend.  Such Investor understands that
               -------------------------------
the Shares have not been, and the Reserved Shares will not be, registered under
the Securities Act or any state securities law, by reason of their issuance in a
transaction exempt from the registration requirements of the Securities Act and
such laws, and that they must be held indefinitely unless they are subsequently
registered under the Securities Act and such laws or a subsequent disposition
thereof is exempt from registration.  Such Investor further understands that
such exemption depends upon, among other things, the bona fide nature of such
                                                     ---- ----
Investor's investment intent expressed herein.  Such Investor acknowledges that
the certificates for the Shares and the Reserved Shares shall bear a legend to
such effect, and appropriate stock transfer instructions may be issued.

          5.4  Status of the Investors.  Such Investor has not been formed for
               -----------------------
the specific purpose of acquiring Shares or Reserved Shares pursuant to this
Agreement.  Such Investor understands the term "accredited investor," as used in
Regulation D promulgated under the Securities Act and represents and warrants to
the Corporation that such Investor is an "accredited investor" for purposes of
acquiring Shares and Reserved Shares.

          5.5  Knowledge and Experience; Economic Risk.  Such Investor has
               ---------------------------------------
sufficient knowledge and experience it business and financial matters and with
respect to investment in securities of privately held companies so as to enable
it to analyze and evaluate the merits and risks of the investment contemplated
hereby and is capable of protecting its interest in connection with this
transaction.  Such Investor is able to bear the economic risk of such
investment, including a complete loss of the investment.

          5.6  Access to Information.  Such Investor acknowledges that such
               ---------------------
Investor and its representatives have had the opportunity to ask questions and
receive answers from officers and representatives of the Corporation concerning
the transactions contemplated by this Agreement, and to obtain any additional
information which the Corporation possesses or can acquire that is necessary to
verify the accuracy of the information regarding the Corporation herein set
forth or otherwise desired in connection with its purchase of the Shares and the
Reserved Shares.

          5.7  Authorization.  The execution, delivery and performance by such
               -------------
Investor of this Agreement have been duly authorized by all requisite action of
such Investor and its partners or equity holders.  This Agreement has been duly
executed and delivered on behalf of such Investor and constitutes the valid and
binding obligation of such Investor, enforceable in accordance with its terms.
The execution, delivery and performance of the Transaction

                                      -9-
<PAGE>

Documents, the purchase of the Shares and the Reserved Shares, and compliance
with the provisions hereof and thereof by such Investor, do not and will not,
with or without the passage of time or the giving of notice or both, (a) violate
any provision of law, statute, rule or regulation or any ruling, writ,
injunction, order, judgment or decree of any court, administrative agency or
other governmental body or (b) conflict with or result in any breach of any of
the terms, conditions or provisions of, or constitute a default (or give rise to
any right of termination, cancellation or acceleration) under, such Investor's
charter, by-laws, partnership agreement or other organizational document, or any
material note, indenture, mortgage, lease, agreement, contract, purchase order
or other instrument, document or agreement to which such Investor is a party or
by which it or any of its property is bound or affected.

          5.8  No Governmental Consent or Approval Required.  No authorization,
               --------------------------------------------
consent, approval or other order of, or declaration to, or filing with, any
governmental agency or body is required to be made or obtained by such Investor
for or in connection with the valid authorization, execution and delivery by
such Investor of the Transaction Documents or for the valid purchase by such
Investor of the Shares to be sold to it hereunder or for or in connection with
the valid issuance to such Investor of any Reserved Shares.

          5.9  Rule 144.  Such Investor understands that the exemption from
               --------
registration afforded by Rule 144 (the provisions of which are known to such
Investor) promulgated by the Securities and Exchange Commission (the
"Commission") under the Securities Act depends upon the satisfaction of various
conditions, that such exemption is not currently available and that, if
applicable, Rule 144 affords the basis for sales only in limited amounts.

     SECTION 6.  Conditions Precedent to Closing by the Investor.  The
     ---------   -----------------------------------------------
obligation of each Investor to purchase and pay for the Shares being purchased
by such Investor at the initial Closing or any Additional Closing (each a
"Closing") is subject to satisfaction (or waiver by the Investor) of the
following conditions precedent at or before such Closing:

          6.1  Corporate Proceedings.  All corporate and other proceedings to be
               ---------------------
taken and all waivers and consents to be obtained in connection with the
transactions contemplated by this Agreement shall have been taken or obtained
and all documents incident to such transactions shall be satisfactory in form
and substance to the Investors and their counsel, who shall have received all
such originals or certified or other copies of such documents as they may
reasonably request.

          6.2  Representations and Warranties Correct.  The representations and
               --------------------------------------
warranties made by the Corporation in Section 4 hereof shall be true and correct
when made, and shall be true and correct in all material respects at the time of
such Closing with the same force and effect as if they had been made at and as
of the time of such Closing.

          6.3  Compliance with Covenants.  The corporation shall have duly
               -------------------------
complied with and performed all covenants and agreements of the Corporation
herein which are required to be complied with and performed at or before such
Closing.

                                      -10-
<PAGE>

          6.4  Certificate of Compliance.  The Corporation shall have provided
               -------------------------
to each of the Investors purchasing Shares at such Closing a certificate, dated
the date of such Closing, in form and substance reasonably satisfactory to such
Investor, confirming compliance with the conditions set forth it Sections 6.2
and 6.3.

          6.5  Opinion of Counsel.  At such Closing, each of the Investors
               ------------------
purchasing Shares at such Closing shall have received from Foley, Hoag & Eliot,
counsel for the Corporation, an opinion addressed to such Investors, dated the
date of the Closing, to the effect set forth in Exhibit 6.5.
                                                -----------

          6.6  Related Agreements and Documents.  At or before such Closing, the
               --------------------------------
parties thereto shall have executed and delivered the  Registration Rights
Agreement and the Voting Agreement, the Corporation and each of the Founders
shall have executed and delivered a Stock Restriction Agreement in the form of
Exhibit 6.6 hereto (each a "Stock Restriction Agreement"), and the Corporation
- -----------
shall have delivered to the Investors such other documents as they shall
reasonably request.

          6.7  Blue Sky Matters.  All consents, approvals, qualifications,
               ----------------
registrations and filings required to be obtained or effected under any
applicable state securities or "blue sky" laws in connection with the issuance,
sale and delivery of the Shares prior to the sale of the Shares shall have been
obtained or effected and copies of the same delivered to each of the Investors.

          6.8  Purchase by Other Investors.  All of the Initial Shares shall
               ---------------------------
have been purchased and paid for at the Initial Closing.

    SECTION 7. Financial Reports.  Subject to the limitations set forth in
    ---------  -----------------
Section 7.6, the Corporation agrees to furnish each of the Investors and any
transferee to which any Investor transfers at least 100,000 Shares (a "Series B
Transferee") with the following:

          7.1  Quarterly and Monthly Reports.  Within 45 days after the end of
               -----------------------------
each month and each fiscal quarter, an unaudited financial report of the
Corporation, which report shall be prepared in accordance with generally
accepted accounting principles consistently applied (except that the financial
report may (i) be subject to normal year-end audit adjustments neither
individually nor in the aggregate material and (ii) not contain all notes
thereto which may be required in accordance with generally accepted accounting
principles) and shall be certified by either the Chief Executive Officer or the
Chief Financial officer of the Corporation to have been so prepared, and which
shall include the following:

          (a)  an income statement for such month or quarter, together with a
cumulative income statement from the first day of the then-current fiscal year
to the last day of such month or quarter;

          (b)  a balance sheet as of the last day of such month or quarter;

          (c)  a statement of cash flows for such month or quarter;

                                      -11-
<PAGE>

          (d)  a comparison between the actual figures for such month or
quarter, the comparable figures (with respect to the foregoing clauses (a) and
(b) only) for the prior year (if any) and the comparable figures included in the
Budget (as hereinafter defined) for such month or quarter, with an explanation
of any material differences between them.

     The financial report for each fiscal quarter shall be accompanied by a
report by the Chief Executive Officer of the Corporation explaining business
developments and problems occurring during the quarter.

          7.2  Annual Reports.  Within 120 days after the end of each fiscal
               --------------
year of the Corporation, audited financial statements of the Corporation, which
shall include an income statement for such fiscal year and a balance sheet as of
the last day thereof, and statements of stockholders' equity and cash flows for
such fiscal year, each prepared in accordance with generally accepted accounting
principles consistently applied, certified by independent certified public
accountants of recognized national standing satisfactory to the Investors,
together with such accountants' annual management letter.

          7.3  Consolidated Financial Statements.  If for any period the
               ---------------------------------
Corporation shall have any subsidiary whose accounts are consolidated with those
of the Corporation, then in respect of such period the financial statements
delivered pursuant to the foregoing Sections 7.1 and 7.2 shall be the
consolidated and consolidating financial statements of the Corporation and all
such consolidated subsidiaries.

          7.4  Other Reports and Information.  Promptly upon becoming available:
               -----------------------------

               (a)  copies of all financial statements, reports, notices, press
     releases, proxy statements and other documents sent by the Corporation to
     its stockholders or released to the public and copies of all regular and
     periodic reports, if any, filed by the Corporation with the Commission or
     any securities exchange; and

               (b)  any other financial or other information available to
     management of the Corporation as any of the Investors shall have reasonably
     requested on a timely basis.

          7.5  Budgets and Operating Plans.  At least 30 days prior to the
               ---------------------------
beginning of each fiscal year of the Corporation, a monthly operating plan of
the Corporation, with monthly breakdowns, for such fiscal year (the "Budget").
The Budget shall be accepted as the Budget for such fiscal year when it has been
approved by the Board of Directors of the Corporation.  The Budget shall be
reviewed by the Corporation periodically and all changes therein and all
material deviations therefrom which are proposed to be made by the Corporation
shall be resubmitted to its Board of Directors and to each of the Investors in
advance and shall be accepted when approved by, and the Corporation shall not
make any such changes or material deviations to or from the Budget without such
prior approval of, its Board of Directors.  The Budget shall include an income
statement, balance sheet and cash flow information.

                                      -12-
<PAGE>

          7.6  Limitations on Rights of Investors under Section 7.  The
               --------------------------------------------------
Corporation shall provide the information required by Sections 7.1 through 7.5
to each Investor and any Series B Transferee so long as such Investor or Series
B Transferee shall own at least 200,000 shares of the Common Stock (including in
such number shares of Common Stock issuable upon Conversion of Series B
Preferred) appropriately adjusted to take account of any stock split, stock
dividend, combination of shares or the like.  The foregoing provisions of this
Section 7 to the contrary notwithstanding, the Investors shall not have any
rights and the Corporation shall not have any obligations under the foregoing
provisions of this Section 7 at such time that the Common Stock is registered
under Section 12 of the Exchange Act.

    SECTION 8. Additional Agreements of the Corporation.
    ---------  ----------------------------------------

    8.1   Right of First Refusal.
          ----------------------

          (a)  Subject to the limitations set forth in paragraph (i) of this
Section 8.1 and in Section 8.9, the Corporation hereby grants to each Investor,
each Founder, and any of their respective permitted assignees described in
paragraph (j) of this Section 8.1 (each a "Right Holder") the right of first
refusal to purchase, pro rata, all (or any part) of any New Securities (as
defined in this Section 8.1(b)) that the Corporation may, from time to time,
propose to sell or issue.  Each such Right Holder's pro rata share, for purposes
of this right of first refusal, is the ratio of (i) the number of shares of
Common Stock then held of record by, or issuable on conversion of Series B
Preferred or Series A Preferred (together, "Preferred Stock") then held of
record by, such Right Holder to (ii) the sum of the total number of shares of
the Common Stock issued and outstanding plus the total number of shares of
Common Stock issuable upon conversion of the Preferred Stock, in each case at
such time (the "Basic Amount").

          (b)  "New Securities" shall mean any equity securities of the
Corporation, whether now authorized or not, and rights, options, or warrants to
purchase said equity securities, and securities of any type whatsoever that are,
or may become, convertible into said equity securities; provided, however, that
                                                        --------  -------
"New Securities" does not include (i) securities offered to the public pursuant
to a registration statement filed under the Securities Act, the gross proceeds
to the Corporation from the sale of which would equal or exceed $10,000,000;
(ii) securities issued pursuant to the acquisition of another corporation by the
Corporation by merger, purchase of substantially all of the assets, or other
reorganization whereby the Corporation acquires not less than 51% of the voting
power of such corporation; (iii) up to 700,000 shares (appropriately adjusted to
take account of any stock split, stock dividend, combination of shares or the
like) of Common Stock (or related options) issued to employees, officers or
other persons performing services for the Corporation pursuant to any stock
offering, plan or arrangement approved by the Board of Directors of the
Corporation, which number may be adjusted upward by the affirmative vote of two-
thirds of the whole Board of Directors; (iv) securities issued in connection
with any stock split, stock dividend or recapitalization by the Corporation; (v)
shares of Common Stock issued upon conversion of the Shares; (vi) securities
issuable upon exercise or conversion of any rights, options, warrants or
convertible securities outstanding on the date of this Agreement; (vii)
securities issued to any financial institution in connection with a loan
transaction approved by the Board of Directors of the Corporation; (viii)
securities issued to vendors or customers or to other persons in similar
commercial situations with the Corporation, provided such issuance is

                                      -13-
<PAGE>

approved by the Board of Directors of the Corporation; (ix) securities issued in
connection with obtaining lease financing, whether issued to a lessor, guarantor
or other person involved in the financing, provided such issuance is approved by
the Board of Directors of the Corporation; or (x) any right, option or warrant
to acquire any security convertible into securities excluded from the definition
of New Securities pursuant to clauses (i) through (ix) above.

          (c)  The Corporation shall not issue, sell or exchange, agree to
issue, sell or exchange, or reserve or set aside for issuance, sale or exchange
any New Securities unless the Corporation shall deliver to each Right Holder a
written notice of any proposed or intended issuance, sale or exchange of New
Securities (the "Offer"), which Offer shall (i) identify and describe the New
Securities, (ii) describe the price and other terms upon which they are to be
issued, sold or exchanged, and the number or amount of the New Securities to be
issued, sold or exchanged, (iii) identify the persons or entities to which or
with which the New Securities are to be offered, issued, sold or exchanged and
(iv) offer to issue and sell to or exchange with such Right Holder (a) such
Right Holder's Basic Amount, and (b) any additional portion of the New
Securities as such Right Holder shall indicate it will purchase or acquire
should the other Right Holders subscribe for less than their Basic Amounts (the
"Undersubscription Amount"). Each Right Holder shall have the right, for a
period of 30 days following delivery of the Offer, to purchase or acquire, at a
price and upon the other terms specified in the Offer, the number or amount of
New Securities described above. The Offer by its terms shall remain open and
irrevocable for such 30-day period.

          (d)  To accept an Offer, in whole or in part, a Right Holder must
deliver a written notice to the Corporation prior to the end of the 30-day
period of the Offer, setting forth the portion of the Right Holder's Basic
Amount that such Right Holder elects to purchase and, if such Right Holder shall
elect to purchase all of its Basic Amount, the Undersubscription Amount (if any)
that such Right Holder elects to purchase (the "Notice of Acceptance").  If the
Basic Amounts subscribed for by all Right Holders are less than the total New
Securities, then each Right Holder who has set forth an Undersubscription Amount
in its Notice of Acceptance shall be entitled to purchase, in addition to the
Basic Amount subscribed for, the Undersubscription Amount it has subscribed for;
provided, however, that should the Undersubscription Amounts subscribed for
- --------  -------
exceed the difference between the New Securities and the Basic Amounts
subscribed for (the "Available Undersubscription Amount"), each Right Holder who
has subscribed for any Undersubscription Amount shall be entitled to purchase
only that portion of the Available Undersubscription Amount as the
Undersubscription Amount subscribed for by such Right Holder bears to the total
Undersubscription Amounts subscribed for by all Right Holders, subject to
rounding by the Board of Directors to the extent it reasonably deems necessary.

          (e)  In the event that Notices of Acceptance are not given by the
Right Holders in respect of all the New Securities, the Corporation shall have
90 days from the expiration of the period set forth in paragraph (c) above to
issue, sell or exchange all or any part of such New Securities as to which a
Notice of Acceptance has not been given by the Right Holders (the "Refused
Securities"), but only to the offerees or purchasers and only upon terms and
conditions (including, without limitation, unit prices and interest rates) which
are described in the Offer.

                                      -14-
<PAGE>

          (f)  In the event the Corporation shall propose to sell less than all
the Refused Securities (any such sale to be in the manner and on  the terms
specified in paragraph (e) above), then each Right Holder may, at its sole
option and in its sole discretion, reduce the number or amount of the New
Securities specified in its Notice of Acceptance to an amount that shall be not
less than the number or amount of the New Securities that the Right Holder
elected to purchase pursuant to paragraph (d) above multiplied by a fraction,
(i) the numerator of which shall be the number or amount of New Securities the
Corporation actually proposes to issue, sell or exchange (including New
Securities to be issued or sold to Right Holders pursuant to paragraph (d) above
prior to such reduction) and (ii) the denominator of which shall be the amount
of all New Securities.  In the event that any Right Holder so elects to reduce
the number or amount of New Securities specified in its Notice of Acceptance,
the Corporation may not issue, sell or exchange more than the reduced number or
amount of the New Securities unless and until such securities have again been
offered to the Right Holders in accordance with paragraph (c) above.

          (g)  Upon the closing of the issuance, sale or exchange of all or less
than all the Refused Securities, the Right Holders shall acquire from the
Corporation, and the Corporation shall issue to the Right Holders, the number or
amount of New Securities specified in the Notices of Acceptance, as reduced
pursuant to paragraph (f) above if the Right Holders have so elected, upon the
terms and conditions specified in the Offer.  The purchase by the Right Holders
of any New Securities is subject in all cases to the preparation, execution and
delivery by the Corporation and the Right Holders of a purchase agreement
relating to such New Securities reasonably satisfactory in form and substance to
the Right Holders and their respective counsel.

          (h)  Any New Securities not acquired by the Right Holders or other
persons in accordance with paragraph (e) above may not be issued, sold or
exchanged until they are again offered to the Right Holders under the procedures
specified in this Agreement.

          (i)  This right of first refusal shall run to each Investor, each
Founder and any of their respective permitted assignees under paragraph (j) of
this Section 8.1 only for so long as they hold the following number of shares of
Common Stock (including in such number shares of Common Stock issuable upon
conversion of Preferred Stock):

               (i)  in the case of the Founders, the Investors who were parties
to the Original Purchase Agreement and their permitted assignees, 50,000 shares;
and

               (ii) in the case of all other Investors and their permitted
assignees, 200,000 shares.

          (j)  This right of first refusal may be assigned, in whole or in part,
(i) to any Affiliate (as hereinafter defined) of any Right Holder or (ii) to any
assignee who acquires not less than 50,000 shares of Common Stock in the case of
an assignment from assignor described in clause (i) of paragraph (i) of this
Section 8.1, or 200,000 shares of Common Stock in the case of an assignment from
an assignor described in clause (ii) of paragraph (i) of this Section 8.1 (in
each case, including in such number shares of Common Stock issuable upon
conversion of Preferred Stock and appropriately adjusted to take account of any
stock split, stock dividend,

                                      -15-
<PAGE>

combination of shares, or the like). As used in this Section, an Affiliate of a
Right Holder shall mean any partner of the Right Holder that is a partnership or
any person or entity that, directly or indirectly, through one or more
intermediaries, controls, or is controlled by, or is under common control with,
the Right Holder.

          (k)  This Section 8.1 shall supersede and replace Section 8 of the
Original Purchase Agreement, which Section 8 shall no longer have any force or
effect.

     8.2  Keeping of Records and Books of Account.  The Corporation shall keep,
          ---------------------------------------
and cause each subsidiary to keep, adequate records and books of account, in
which complete entries will be made in accordance with generally accepted
accounting principles consistently applied, reflecting all financial
transactions of the Corporation and such subsidiary, and in which, for each
fiscal year, all proper reserves for depreciation, depletion, obsolescence,
amortization, taxes, bad debts and other purposes in connection with its
business shall be made.

     8.3  Insurance.  The Corporation will do or cause to be done all things
          ---------
necessary to preserve and maintain in full force and effect fire and casualty
insurance policies, with extended coverage, on its properties, assets, business
and personnel, in amounts deemed adequate by the Corporation, and in accordance
with the standards of the industry in which the Corporation operates, sufficient
in amount to allow it to replace any of its properties which might be damaged or
destroyed.

     8.4  Key Man Life Insurance.  The Corporation shall use its best efforts to
          ----------------------
obtain and thereafter maintain in force a policy of life insurance, naming the
Corporation as beneficiary, on the life of Dr. Hubert Koster, in the amount of
US$1,000,000, once Dr. Koster becomes an employee of the Corporation.

     8.5  Maintenance of Corporate Existence, etc.  The Corporation will do or
          ---------------------------------------
cause to be done all reasonable things necessary to preserve and keep in full
force and effect its existence and all of its rights (charter and statutory),
subject in all cases to the exercise by the Board of Directors of the
Corporation of their fiduciary obligations.  The Corporation shall comply in all
respects with the provisions of its Certificate of Incorporation and By-laws.

     8.6  Maintenance of Facilities.  The Corporation will cause all facilities
          -------------------------
owned or leased in the conduct of its business to be maintained and kept in good
condition and repair and will cause to be made all necessary repairs, renewals,
replacements, betterments and improvements thereof, all as in the judgment of
the Corporation may be necessary so that the business carried on in connection
therewith may be properly and advantageously conducted at all times;
provided, however, that nothing in this Section shall prevent the Corporation
- --------  -------
from discontinuing the lease or maintenance of any such facilities if such
discontinuance is, in the good faith judgment of the Board of Directors of the
Corporation, desirable in the conduct of its business and would not have a
material adverse effect on the Corporation.

     8.7  Payment of Taxes.  The Corporation will pay or discharge or cause to
          ----------------
be paid or discharged, before the same shall become delinquent, (1) all material
taxes, assessments and governmental charges levied or imposed upon the
Corporation or upon the income, profits or

                                      -16-
<PAGE>

property of the Corporation; and (2) all material liabilities of the
Corporation; provided, however, that the Corporation shall not be required to
             --------  -------
pay or discharge or cause to be paid or discharged any such tax assessment,
liability, or charge, whose amount, applicability or validity is being contested
in good faith by appropriate proceedings if adequate reserves therefor have been
established in accordance with generally accepted accounting principles.

     8.8  Compliance with Applicable Laws.  The Corporation shall conduct its
          -------------------------------
business in compliance in all material respects with all laws and valid
requirements of governmental authorities relating to the conduct of its business
or to its properties or assets.

     8.9  Limitation On Rights of Investors.  The rights of Right Holders under
          ---------------------------------
Section 8.1 and the Investors under Section 8.2 through 8.8, inclusive, and the
obligations of the Corporation under Sections 8.1 through 8.8, inclusive, shall
terminate and be of no effect upon and following the closing of a firm
commitment underwritten public offering of the Corporation's Common Stock
pursuant to an effective registration statement under the Securities Act in
which (i) the offering price per share is not less than $4.50 (prior to
underwriter's discounts and commissions), appropriately adjusted to take account
of any stock split, stock dividend, combination of shares, or the like, and (ii)
the aggregate net proceeds to the Corporation from such offering are not less
than $10 million.

     8.10  Proprietary Information and Invention Assignment Agreements.  As soon
           -----------------------------------------------------------
as practicable after the Initial Closing, the Corporation will use reasonable
efforts to cause each senior technical employee who has not already signed an
agreement with the Corporation relating to the protection of proprietary
information and the assignment of inventions to sign such an agreement in a form
acceptable to the Board of Directors of the Corporation.

     SECTION 9.   Expenses.
     ---------    --------

     9.1  Expenses.  The Corporation shall pay the reasonable fees and
          --------
disbursements of Bingham, Dana & Gould, special counsel to Boston University
Nominee Partnership, in connection with the transactions contemplated by this
Agreement, up to a maximum amount of $10,000.  Otherwise, the Corporation and
the Investors shall each bear their own expenses, including the fees and
disbursements of their respective counsel, incurred in connection with the
purchase and sale of the Shares.

     9.2  Brokers.  No party to this Agreement has employed any broker or finder
          -------
in connection with the transactions contemplated hereby.  No person or entity
will have, as a result of the transactions contemplated by this Agreement, any
right, interest or valid claim against or upon any such party of any commission,
fee or other compensation as a finder or broker because of any act or omission
by such party or any agent of such party.  Each party to this Agreement agrees
to indemnify and hold the others harmless from payment of any brokerage fee,
finders fee, or commission claimed by any third party who claims to have been
involved because of association with such party.

     SECTION 10.  Exchanges; Lost, Stolen or Mutilated Certificates.  Upon
     ----------   -------------------------------------------------
surrender by any Investor to the Corporation of a certificate or certificates
representing shares of Series B

                                      -17-
<PAGE>

Preferred purchased or acquired by such Investor hereunder or Reserved Shares
received upon conversion of any such shares of Series B Preferred, the
Corporation at its expense shall issue in exchange therefor, and deliver to such
Investor, a new certificate or certificates representing such shares, in such
denomination or denominations as may be requested by such Investor. Upon receipt
of evidence satisfactory to the Corporation of the loss, theft, destruction or
mutilation of any certificate representing any shares of Series B Preferred
purchased or acquired by the Investor hereunder or Reserved Shares received upon
conversion of any such shares of Series B Preferred and in case of any such
loss, theft or destruction, upon delivery of any indemnity agreement
satisfactory to the Corporation, or in case of any such mutilation, upon
surrender and cancellation of such certificate, the Corporation at its expense
shall issue and deliver to such Investor a new certificate for such shares of
Series B Preferred or Reserved Shares, of like tenor, in lieu of such lost,
stolen or mutilated certificate.

     SECTION 11.  Survival of Representations, Warranties and Agreements.  The
     ----------   ------------------------------------------------------
covenants, representations and warranties of the parties contained herein shall
survive any Closing hereunder.  Each of the parties may rely on such covenants,
representations and warranties irrespective of any investigation made, or notice
or knowledge held by, it or any other person.  All statements contained in any
certificate or other instrument delivered by any party pursuant to this
Agreement or in connection with the transactions contemplated by this Agreement
shall constitute representations and warranties by such party under this
Agreement.

     SECTION 12.  Remedies.  In case any one or more of the covenants or
     ----------   --------
agreements set forth in this Agreement shall have been breached by the
Corporation, the Investors may proceed to protect and enforce their rights
either by suit in equity or by action at law, including, but not limited to, an
action for damages as a result of any such breach or an action for specific
performance of any such covenant or agreement contained in this Agreement.

     SECTION 13.  Successors and Assigns.  This Agreement shall be binding upon,
     ----------   ----------------------
and inure to the benefit of, each of the parties hereto and, except as otherwise
expressly provided herein, each other person who shall become a registered
holder named in any certificate evidencing shares of Common Stock or Series B
Preferred transferred to such holder by any of the Investors or their permitted
transferees, and (except as aforesaid) their respective legal representatives,
successors and assigns.

     SECTION 14.  Entire Agreement; Effect on Prior Documents.  This Agreement
     ----------   -------------------------------------------
and the other documents referred to herein or delivered pursuant hereto contain
the entire agreement among the parties with respect to the financing
transactions contemplated hereby and supersede all prior negotiations,
commitments, agreements-and understandings among them with respect thereto.

     SECTION 15.  Notices.  All notices, requests, consents and other
     ----------   -------
communications hereunder to any party shall be deemed to be sufficient if
contained in a written instrument delivered in person or duly sent by first-
class mail, postage prepaid, or by any internationally recognized express
courier service, addressed to such party at the address set forth below or such
other address as may hereafter be designated in writing by the addressee to the
addressor listing all parties:

                                      -18-
<PAGE>

          (i)  if to the Corporation, to:

               Sequenom, Inc.
               c/o TVM Techno Venture Management
               101 Arch Street
               Suite 1950
               Boston, MA 02110
               Attention:  President

               with a copy to:

               David R. Pierson, Esq.
               Foley, Hoag & Eliot
               One Post Office Square
               Boston, Massachusetts 02109

          (ii) if to the Investors, to their respective addresses set forth on
               the Schedule of Investors.

     SECTION 16.  Amendments; waivers.  This Agreement may be amended, and
     ----------   -------------------
compliance with the provisions of this Agreement may be omitted or waived, by
the written agreement of the Corporation and Investors or assignees of their
rights hereunder holding 85% in voting power of the Series B Preferred (and
Common Stock issued upon conversion thereof) held by the Investors and such
assignees.

     SECTION 17.  Counterparts.  This Agreement may be executed in any number of
     ----------   ------------
counterparts, each such counterpart shall be deemed to be an original
instrument, and all such counterparts together shall constitute but one
agreement.  Any such counterpart may contain one or more signature pages.

     SECTION 18.  Headings.  The headings of the various sections of this
     ----------   --------
Agreement have been inserted for convenience of reference only and shall not be
deemed to be a part of this Agreement.

     SECTION 19.  Nouns and Pronouns.  Whenever the context may require, any
     ----------   ------------------
pronouns used herein shall include the corresponding masculine, feminine or
neuter forms, and the singular form of names and pronouns shall include the
plural and vice-versa.

     SECTION 20.  Governing Law.  This Agreement shall be governed by, and
     ----------   -------------
construed and enforced in accordance with, the substantive laws of The
Commonwealth of Massachusetts, without regard to its principles of conflicts of
laws.

     SECTION 21.  Severability.  Any provision of this Agreement that is
     ----------   ------------
prohibited or unenforceable in any jurisdiction shall, as to such jurisdiction,
be ineffective to the extent of such prohibition or unenforceability without
invalidating the remaining provisions hereof, and any

                                      -19-
<PAGE>

such prohibition or unenforceability in any jurisdiction shall not invalidate or
render unenforceable such provision in any other jurisdiction.

     SECTION 22.  Information Confidential.  Each Investor acknowledges that the
     ----------   ------------------------
information received by it pursuant hereto (including without limitation under
Section 7 hereof) is confidential and for its use only and such Investor will
not reproduce, disclose or disseminate such information to any other person
(other than its employees or agents having a need to know the contents of such
information), except in connection with the exercise of rights under this
Agreement, unless the Corporation has made such information available to the
public generally or such Investor is required to disclose such information by
law or by any court or other governmental body.  The obligation of
confidentiality set forth in this Section shall not apply to information (i)
generally known on a non-confidential basis (without fault of an Investor) to
companies in the Corporation's line of business; (ii) lawfully obtained by an
Investor without restriction on disclosure; (iii) known to an Investor prior to
receipt from the Corporation without restriction on disclosure; or (iv)
independently developed by an Investor without use of information provided by
the Corporation.

     IN WITNESS WHEREOF, the undersigned have executed this Agreement as of the
day and year first written above.

                              SEQUENOM, INC.


                              By: /s/ illegible
                                 ----------------------------------------
                                     Its Treasurer

                                      -20-
<PAGE>

     For purposes of Section 8.1 only:

                                          FOUNDERS:


                                              /s/ Hubert Koster
                                            -------------------------
                                            Hubert Koster


                                              /s/ Nola E. Masterson
                                            -------------------------
                                            Nola E. Masterson


                                              /s/ Robert E. Patterson
                                            -------------------------
                                            Robert E. Patterson

                                      -21-
<PAGE>

                                 SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     EXECUTED this 22nd day of December, 1995.



                              TVM Techno Venture Enterprises No. II
                              Limited Partnership
                              -------------------------------------------
                              (Print name)


  212,267                     By:  /s/ illegible
- ---------------------            ----------------------------------------
Shares Purchased
                              Title:  Treasurer
                                    -------------------------------------
  $318,400.50
- ---------------------
Total Purchase Price          Address:  101 Arch St.
                                      -------------------------------------

                                        Suite 1950
                                      -------------------------------------

                                        Boston, Massachusetts  02110
                                      -------------------------------------
<PAGE>

                                 SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     EXECUTED this 22nd day of December, 1995.



                              TVM Intertech Limited Partnership
                              ------------------------------------------
                              (Print name)


  141,513                     By:  /s/ illegible
- -----------------------          ---------------------------------------
Shares Purchased
                              Title:  Treasurer
                                    ------------------------------------
  $212,269.50
- -----------------------
Total Purchase Price          Address:  101 Arch St.
                                      ----------------------------------

                                      Suite 1950
                              ------------------------------------------

                                      Boston, Massachusetts  02110
                              ------------------------------------------
<PAGE>

                                 SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     EXECUTED this 22nd day of December, 1995.



                              TVM Zweite Beteiligung - U.S.
                              Limited Partnership
                              ----------------------------------------
                              (Print name)


  432,953                     By:  /s/ illegible
- -----------------------          -------------------------------------
Shares Purchased
                              Title:  Treasurer
                                    ----------------------------------
  $649,429.50
- -----------------------
Total Purchase Price          Address:  101 Arch St.
                                      --------------------------------

                                      Suite 1950
                              ----------------------------------------

                                      Boston, Massachusetts  02110
                              ----------------------------------------
<PAGE>

                                 SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement


                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     EXECUTED this 22nd day of December, 1995.



                              TVM Eurotech Limited Partnership
                              --------------------------------
                              (Print name)


  288,633                     By:  /s/ illegible
- ---------------------            ------------------------------------
Shares Purchased
                              Title:  Treasurer
                                    ---------------------------------
  $432,949.50
- ---------------------
Total Purchase Price          Address:  101 Arch St.
                                      -------------------------------

                                      Suite 1950
                              ---------------------------------------

                                      Boston, Massachusetts  02110
                              ---------------------------------------
<PAGE>

                                 SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     EXECUTED this 22nd day of December, 1995.



                              TVM Techno Venture Investors No. 1
                              Limited Partnership
                              -------------------
                              (Print name)


  12,634                      By:  /s/ illegible
- ---------------------            --------------------------------------
Shares Purchased
                              Title:  General Partner
                                    -----------------------------------
  $18,951.00
- ---------------------
Total Purchase Price          Address:  101 Arch St.
                                      ---------------------------------

                                      Suite 1950
                              -----------------------------------------

                                      Boston, Massachusetts  02110
                              -----------------------------------------
<PAGE>

                                 SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     EXECUTED this 22nd day of December, 1995.



                              ***
                              ------------------------------------------
                              (Print name)


  245,333                     By:  /s/ illegible
- ------------------------      ------------------------------------------
Shares Purchased                 illegible         illegible

                              Title:   ***         ***
                                    ------------------------------------
                                                     ***
                                    ------------------------------------

  $367,999.50
- ------------------------
Total Purchase Price          Address: ***
                                      ---------------------------------

                                       ***
                              -----------------------------------------


/***/ Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                 SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement


                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     EXECUTED this 22nd day of December, 1995.



                              Alpinvest International B.V.
                              -----------------------------------
                              (Print name)


  666,667                     By:  /s/ illegible
- ----------------------           --------------------------------
Shares Purchased
                              Title:_____________________________
  $1,000,000.50
- ----------------------
Total Purchase Price          Address:  Gooimeer 3
                                      ---------------------------

                                      NL - 1410 AB Naarden
                              -----------------------------------

                                      The Netherlands
                              -----------------------------------
<PAGE>

                                 SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     EXECUTED this 22nd day of December, 1995.



                              ***
                              --------------------------------------
                              (Print name)


  333,333                     By:  ***
- ---------------------            -----------------------------------
Shares Purchased                    ***

                              Title:  ***
                                    --------------------------------
  $499,999.50
- ---------------------
Total Purchase Price          Address:  ***
                                      ------------------------------

                                      ***
                              --------------------------------------


*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                 SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement

                       Additional Investor Signature Page
                       ----------------------------------


     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series B Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

     EXECUTED this 21 day of February, 1996.


                                    ***
                                    --------------------------------------
                                    ***


                                    Address:  ***
                                            ------------------------------


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------



     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series B Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

     EXECUTED this 23 day of February, 1996.


                                        ***
                                        ------------------------------------
                                        ***


                                        Address:  ***
                                                -----------------------------


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------



     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series B Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

     EXECUTED this 6 day of February, 1996.


                                             ***
                                             ------------------------------
                                             ***


                                             Address:  ***
                                                     ------------------------


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                 SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------



     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series B Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

     EXECUTED this 5 day of February, 1996.


                                             ***
                                             -------------------------------
                                             ***


                                             Address:  ***
                                                     -----------------------


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------



     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series B Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

     EXECUTED this 29th day of February, 1996.


                                   TVM TECHNO VENTURE INVESTORS
                                   NO. 1 LIMITED PARTNERSHIP


                                   By: /s/  Illegible
                                       --------------------

                                   Title: General Partner
                                          -----------------

                                   Address: c/o TVM Venture
                                            Management
                                            101 Arch Street
                                            Suite 1950
                                            Boston, MA 02210
<PAGE>

                                 SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------



     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series B Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

     EXECUTED this 29 day of February, 1996.


                                             ***
                                             -------------------------------
                                             ***


                                             Address:  ***
                                                     ------------------------


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------



     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series B Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

     EXECUTED this 14 day of February, 1996.


                                             ***
                                             -----------------------------
                                             ***


                                             Address:  ***
                                                     ---------------------


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------



     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series B Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

     EXECUTED this 29th day of February, 1996.


                                        /s/  Hubert Koster
                                        ------------------
                                        Hubert Koster

                                        Address:  Stapolstrasse 56
                                                  D 22529
                                                  Hamburg, Germany

                                                  Prof. Dr. Hubert Koster
                                                  Hallerstradle 74
                                                  20146 Hamburg
<PAGE>

                                SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------



     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series B Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

     EXECUTED this 29 day of March, 1996.


                                             ***
                                             --------------------------
                                             ***

                                             By:        ***
                                                -----------------------

                                             Title:     ***
                                                   --------------------
                                                   By:  ***

                                             Address:   ***
                                                     ------------------


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------



     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series B Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

     EXECUTED this 29 day of March, 1996.


                                        ***
                                        -------------------------------
                                        ***

                                        By:         ***
                                           ---------------------------

                                        Title:      ***
                                              ------------------------
                                               By:  ***

                                        Address:    ***
                                                ----------------------


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                 SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------



     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series B Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

     EXECUTED this 29 day of March, 1996.


                                             ***
                                             ------------------------------
                                             ***

                                             By:        ***
                                                ---------------------------

                                             Title:     ***
                                                   ------------------------
                                                   By:  ***

                                             Address:   ***
                                                     ----------------------


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                 SEQUENOM, INC.

            Series B Convertible Preferred Stock Purchase Agreement

                       Additional Investor Signature Page
                       ----------------------------------



     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of December 22, 1995,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series B Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

     EXECUTED this 28 day of March, 1996.


                              /s/  Dr. Ernst-Gnter Afting
                              -------------------------------------
                              Professor Dr. Ernst-Gnter Afting

                              Address:  Maisenweg 21
                                        82152 Krailing
                                        Germany
<PAGE>

                             SCHEDULE OF INVESTORS

<TABLE>
<CAPTION>
                                                             Number of Shares of                        Aggregate
Investor                                                     Series B Preferred Stock                   Purchase Price
- --------                                                     ------------------------                   --------------
<S>                                                          <C>                                        <C>
TVM Techno Venture                                                   212,267                             $  318,400.50
  Enterprises No. II Limited Partnership
c/o TVM Techno Venture
  Management ("TVM"),
101 Arch Street, Suite 1950
Boston, MA  02210

TVM Intertech Limited Partnership                                    141,513                             $  212,269.50
c/o TVM

TVM Zweite Beteiligung-U.S.                                          432,953                             $  649,429.50
  Limited Partnership
c/o TVM

TVM Eurotech Limited Partnership                                     288,633                             $  432,949.50
c/o TVM

TVM Techno Venture                                                    12,634                             $   18,951.00
  Investors No. 1 Limited Partnership
c/o TVM

***                                                                  245,333                             $  367,999.50

Alpinvest International B.V.                                         666,667                             $1,000,000.50
Gooimeer 3
NL-1410 AB Naarden
The Netherlands
Attn:  John van Grootel

***                                                                  333,333                             $  499,999.50
</TABLE>


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                     TO THE
                         SERIES B CONVERTIBLE PREFERRED
                            STOCK PURCHASE AGREEMENT
                         DATED AS OF DECEMBER 22, 1995



<TABLE>
<CAPTION>
                                                        Number of Shares of                         Aggregate
Investor                                              Series B Preferred Stock                    Purchase Price
- --------                                              ------------------------                    --------------
<S>                                                   <C>                                         <C>
***                                                           13,333                                  $20,000
</TABLE>


     ***
- -----------------------------------------
     ***

Date:  2/21/96
     ------------------------------------


Accepted and agreed to this
29th day of February, 1996


SEQUENOM, INC.


By:   /s/ illegible
   ----------------------------------------
     Its: Treasurer


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                     TO THE
                         SERIES B CONVERTIBLE PREFERRED
                            STOCK PURCHASE AGREEMENT
                         DATED AS OF DECEMBER 22, 1995


<TABLE>
<CAPTION>
                                                                 Number of Shares of                         Aggregate
Investor                                                       Series B Preferred Stock                    Purchase Price
- --------                                                       ------------------------                    --------------
<S>                                                            <C>                                         <C>
***                                                                      6,666                                 $10,000
</TABLE>




   ***
- -------------------------------------
   ***


Date:  23 February 1996
     --------------------------------


Accepted and agreed to this
29th day of February, 1996


SEQUENOM, INC.


By:  /s/ illegible
   -----------------------------------
     Its: Treasurer


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                     TO THE
                         SERIES B CONVERTIBLE PREFERRED
                            STOCK PURCHASE AGREEMENT
                         DATED AS OF DECEMBER 22, 1995



<TABLE>
<CAPTION>
                                                        Number of Shares of                         Aggregate
Investor                                              Series B Preferred Stock                    Purchase Price
- --------                                              ------------------------                    --------------
<S>                                                   <C>                                         <C>
***                                                             66,666                                $100,000
</TABLE>




    ***
- ---------------------------------
    ***


Date:  February 6, 1996
     ----------------------------


Accepted and agreed to this
29th day of February, 1996


SEQUENOM, INC.


By:  /s/ illegible
   ------------------------------
     Its: Treasurer


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                     TO THE
                         SERIES B CONVERTIBLE PREFERRED
                            STOCK PURCHASE AGREEMENT
                         DATED AS OF DECEMBER 22, 1995



<TABLE>
<CAPTION>
                                                        Number of Shares of                         Aggregate
Investor                                              Series B Preferred Stock                    Purchase Price
- --------                                              ------------------------                    --------------
<S>                                                    <C>                                        <C>
***                                                             20,000                                $30,000
</TABLE>




   ***
- --------------------------------
   ***


Date:  05/Feb/1996
     ---------------------------


Accepted and agreed to this
29th day of February, 1996


SEQUENOM, INC.


By:  /s/ illegible
   -------------------------------
     Its: Treasurer


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                     TO THE
                         SERIES B CONVERTIBLE PREFERRED
                            STOCK PURCHASE AGREEMENT
                         DATED AS OF DECEMBER 22, 1995



<TABLE>
<CAPTION>
                                                        Number of Shares of                         Aggregate
Investor                                              Series B Preferred Stock                    Purchase Price
- --------                                              ------------------------                    --------------
<S>                                                   <C>                                         <C>
TVM Techno Venture                                             6,666                                 $10,000
Investors No. 1
Limited Partnership
</TABLE>



TVM TECHNO VENTURE INVESTORS
NO. 1 LIMITED PARTNERSHIP


By:  /s/ illegible
   ----------------------------------

Title:  General Partner
      -------------------------------


Accepted and agreed to this
29th day of February, 1996


SEQUENOM, INC.


By:  /s/ illegible
   ----------------------------------
     Its: Treasurer
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                     TO THE
                         SERIES B CONVERTIBLE PREFERRED
                            STOCK PURCHASE AGREEMENT
                         DATED AS OF DECEMBER 22, 1995



<TABLE>
<CAPTION>
                                                        Number of Shares of                         Aggregate
Investor                                              Series B Preferred Stock                    Purchase Price
- --------                                              ------------------------                    --------------
<S>                                                   <C>                                         <C>
***                                                             33,333                                $50,000
</TABLE>




   ***
- -----------------------------------
   ***


Date:  2/29/96
     ------------------------------


Accepted and agreed to this
29th day of February, 1996


SEQUENOM, INC.


By:  /s/ illegible
   --------------------------------
     Its: Treasurer


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                     TO THE
                         SERIES B CONVERTIBLE PREFERRED
                            STOCK PURCHASE AGREEMENT
                         DATED AS OF DECEMBER 22, 1995



<TABLE>
<CAPTION>
                                                        Number of Shares of                         Aggregate
Investor                                              Series B Preferred Stock                    Purchase Price
- --------                                              ------------------------                    --------------
<S>                                                   <C>                                         <C>
***                                                            33,333                                $50,000
</TABLE>


   ***
- ----------------------------------
   ***


Date:  Feb 14 1996
     -----------------------------


Accepted and agreed to this
29th day of February, 1996


SEQUENOM, INC.


By:  /s/ illegible
   -------------------------------
     Its: Treasurer


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                     TO THE
                         SERIES B CONVERTIBLE PREFERRED
                            STOCK PURCHASE AGREEMENT
                         DATED AS OF DECEMBER 22, 1995



<TABLE>
<CAPTION>
                                                        Number of Shares of                         Aggregate
Investor                                              Series B Preferred Stock                    Purchase Price
- --------                                              ------------------------                    --------------
<S>                                                   <C>                                         <C>
Hubert Koster                                                  100,000                               $150,000
</TABLE>




/s/ Hubert Koster
- ------------------------------------
Hubert Koster


Date:  2/29/96
     -------------------------------


Accepted and agreed to this
29th day of February, 1996


SEQUENOM, INC.


By:  /s/ illegible
   ----------------------------------
     Its: Treasurer
<PAGE>

                                   EXHIBIT 1
                                   ---------


                            Certificate of Amendment
                            ------------------------

<PAGE>

                            CERTIFICATE OF AMENDMENT
                                       OF
                          CERTIFICATE OF INCORPORATION
                               OF SEQUENOM, INC.


     Sequenom, Inc., a corporation organized and existing under and by virtue of
the General Corporation Law of the State of Delaware, DOES HEREBY CERTIFY:

     FIRST:  That at a meeting of the Board of Directors of said corporation
             resolutions were duly adopted proposing and declaring advisable
             that the Certificate of Incorporation of said corporation be
             amended and that such amendment be submitted to the stockholders of
             the Corporation for their consideration, as follows:

                    RESOLVED:  That the Board of Directors of this Corporation
                               recommends and deems it advisable that the
                               Certificate of Incorporation of this Corporation,
                               as heretofore amended, be further amended by
                               deleting Article FOURTH thereof and substituting
                               for said Article FOURTH the new Article FOURTH
                               set forth on Exhibit A attached hereto; and
                                            ---------

                    RESOLVED:  That the aforesaid proposed amendment be
                               submitted to the stockholders of the Corporation
                               for their consideration; and

                    RESOLVED:  That following the approval by the stockholders
                               of the aforesaid amendment as required by law,
                               the officers of this Corporation be, and they
                               hereby are, and each of them hereby is,
                               authorized and directed (i) to prepare, execute
                               and file with the Secretary of State of the State
                               of Delaware a Certificate of Amendment setting
                               forth the aforesaid amendment in the form
                               approved by the stockholders and (ii) to take any
                               and all other actions necessary, desirable or
                               convenient to give effect to the aforesaid
                               amendment or otherwise to carry out the purposes
                               of the foregoing Resolutions.

                    SECOND:    That in lieu of a meeting and vote of
                               stockholders, the stockholders have given written
                               consent to said amendments in accordance with the
                               provisions of section 228 of the General
                               Corporation Law of the State of Delaware, and
                               written notice of the adoption of the amendments
                               has been given as
<PAGE>

                               provided in section 228 of the General
                               Corporation Law of the State of Delaware to every
                               stockholder entitled to such notice.

                    THIRD:     That the aforesaid amendments were duly adopted
                               in accordance with the applicable provisions of
                               sections 228 and 242 of the General Corporation
                               Law of the State of Delaware.

     IN WITNESS WHEREOF, said Sequenom, Inc. has caused this certificate to be
signed by Randall R. Lunn, its President, and attested by David R. Pierson, its
Secretary, this 22nd day of December, 1995.

ATTEST:                                      SEQUENOM, INC.

By:  /s/ David R. Pierson                    By:  /s/ Randall R. Lunn
   ------------------------------               -------------------------------
     Secretary                                   President

                                      -2-
<PAGE>

                                   EXHIBIT A
                                   ---------

FOURTH:  The total number of shares of all classes of stock which the
- ------
Corporation has authority to issue is 10,753,366 shares, consisting of 5,726,700
shares of Common Stock, par value $.001 per share (the "Common Stock"),
1,650,000 shares of Series A Convertible Preferred Stock, par value $0.001 per
share (the "Series A Preferred Stock"), and 3,376,666 shares of Series B
Convertible Preferred Stock, par value $.001 per share (the "Series B Preferred
Stock", and, together with the Series A Preferred Stock, the "Preferred Stock"),
amounting to an aggregate par value of $10,753.37.

     The powers, preferences and rights, and the qualifications, limitations or
restrictions thereof, in respect of each class or series of stock of the
corporation shall be as follows:

     Section 1.  Liquidation Rights.
     ---------   ------------------

          (a)  In the event of any liquidation, dissolution or winding up of the
affairs of the Corporation, whether voluntary or involuntary, the holders of
each share of the Series B Preferred Stock shall be entitled to be paid first
out of the assets of the Corporation available for distribution to holders of
the Corporation's capital stock of all classes an amount equal to the greater
of:

               (i)  $1.50 per share of Series B Preferred Stock (which amount
     shall be subject to equitable adjustment whenever there shall occur a stock
     dividend, stock split, combination of shares, reclassification or other
     similar event with respect to the Series B Preferred Stock) plus all
     dividends declared but unpaid thereon, to and including the date full
     payment shall be tendered to the holders of the Series B Preferred Stock
     with respect to such liquidation, dissolution or winding up, or

               (ii) such amount per share of Series B Preferred Stock as would
     have been payable had all shares of Series B Preferred Stock been converted
     to Common Stock immediately prior to such event of liquidation, dissolution
     or winding up pursuant to the provisions of Section 2 hereof, plus all
     dividends declared but unpaid on each share of Series B Preferred Stock to
     and including the date full payment shall be tendered to the holders of the
     Series B Preferred Stock with respect to such liquidation, dissolution or
     winding up.

     If the assets of the Corporation shall be insufficient to permit the
payment in full to the holders of the Series B Preferred Stock of all amounts so
distributable to them, then the entire assets of the Corporation available for
such distribution shall be distributed ratably among the holders of the Series B
Preferred Stock in proportion to the full preferential amount each such holder
is otherwise entitled to receive.

     After such payments shall have been made in full to the holders of the
Series B Preferred Stock or funds necessary for such payments shall have been
not aside by the Corporation in trust
<PAGE>

for the account of holders of Series B Preferred Stock so as to be available for
such payments, the holders of each share of the Series A Preferred Stock shall
be entitled to be paid out of the assets of the Corporation available for
distribution to holders of the Corporation's capital stock of all classes an
amount equal to the greater of:

               (i)  $0.50 per share of Series A Preferred Stock (which amount
     shall be subject to equitable adjustment whenever there shall occur a stock
     dividend, stock split, combination of shares, reclassification or other
     similar event with respect to the Series A Preferred Stock) plus all
     dividends declared but unpaid thereon, to and including the date full
     payment shall be tendered to the holders of the Series A Preferred Stock
     with respect to such liquidation, dissolution or winding up, or

               (ii) such amount per share of Series A Preferred Stock as would
     have been payable had all shares of Series A Preferred Stock been converted
     to Common Stock immediately prior to such event of liquidation, dissolution
     or winding up pursuant to the provisions of Section 2 hereof, plus all
     dividends declared but unpaid on each share of Series A Preferred Stock to
     and including the date full payment shall be tendered to the holders of the
     Series A Preferred Stock with respect to such liquidation, dissolution or
     winding up.

     If the assets of the Corporation shall be insufficient to permit the
payment in full to the holders of the Series A Preferred Stock of all amounts so
distributable to them, then the entire remaining assets of the Corporation
available for such distribution shall be distributed ratably among the holders
of the Series A Preferred Stock in proportion to the full preferential amount
each such holder is otherwise entitled to receive.

     After such payments shall have been made in full to the holders of the
Series B Preferred Stock and to the holders of the Series A Preferred Stock, or
funds necessary for such payments shall have been set aside by the Corporation
in trust for the account of holders of Preferred Stock so as to be available for
such payments, the remaining assets available for distribution shall be
distributed among the holders of the Common Stock ratably in proportion to the
number of shares of Common Stock held by them.

     Upon conversion of shares of Series B Preferred Stock or Series A Preferred
Stock into shares of Common Stock Pursuant to Section 2 below, the holder of
such Common Stock shall not be entitled to any preferential payment or
distribution in case of any liquidation dissolution or winding up, but shall
share ratably in any distribution of the assets of the Corporation to all the
holders of Common Stock.

     The amounts payable with respect to shares of Series B Preferred Stock and
Series A Preferred Stock under this Section 1(a) are sometimes hereinafter
referred to as "Series B Liquidation Payments" and "Series A Liquidation
Payments," respectively, and together are sometimes hereinafter referred to as
the "Liquidation Payments."

          (b)  Distributions Other than Cash.  Whenever the distributions
               -----------------------------
provided for in this Section 1 shall be payable in property other than cash, the
value of such distributions shall be

                                      -2-
<PAGE>

the fair market value of such property as determined in good faith by the Board
of Directors of the Corporation.

          (c)  Merger as Liquidation, etc.  The merger or consolidation of the
               --------------------------
Corporation into or with another corporation (except one in which the holders of
capital stock of the Corporation immediately prior to such merger or
consolidation continue to hold at least eighty percent (80%) in voting power of
the capital stock of the surviving corporation, in which case the provisions of
Subsection 2(h) shall apply), or the sale of all or substantially all of the
assets of the Corporation, shall be deemed to be a liquidation, dissolution or
winding up of the affairs of the Corporation for purposes of this Section 1 with
respect to the Series B Preferred Stock unless the holders of at least eighty-
five percent (85%) of the then outstanding shares of the Series B Preferred
Stock elect to the contrary, and with respect to the Series A Preferred Stock
unless the holders of at least eighty percent (80%) of the then outstanding
shares of the Series A Preferred Stock elect to the contrary, such election in
either case to be made by giving written notice thereof to the Corporation at
least three days before the effective date of such event.  If such notice is
given with respect to the Series B Preferred Stock or the Series A Preferred
Stock, the provisions of Subsection 2(h) shall apply to such Series B Preferred
Stock or Series A Preferred Stock, as the case may be.  Unless such election is
made, any amounts received by the holders of the Series B Preferred Stock and
the Series A Preferred Stock as a result of such merger or consolidation shall
be deemed to be applied toward, and all consideration received by the
Corporation in such asset sale together with all other available assets of the
Corporation shall be distributed toward, the Liquidation Payments attributable
to such shares of Series B Preferred Stock and Series A Preferred Stock,
respectively, in the order of preference set forth in Section 1.

          (d)  Notice.  Written notice of any proposed liquidation, dissolution
               ------
or winding up of the affairs of the corporation (including any merger,
consolidation or sale of assets which may be deemed to be a liquidation,
dissolution or winding up of the affairs of the corporation under Subsection
1(c)), stating a payment date, the amount of the Liquidation Payments and the
place where said Liquidation Payments shall be payable, shall be given by first
class mail, postage prepaid, or by telex to non-U.S. residents, not less than
twenty (20) days prior to the payment date stated therein, to the holders of
record of the Series B Preferred Stock and the Series A Preferred Stock, such
notice to be addressed to each such holder at its address as shown by the
records of the Corporation.

     Section 2.  Conversion.  The holders of Preferred stock shall have
     ---------   ----------
conversion rights as follows (the "Conversion Rights"):

          (a)  Right to Convert; Conversion Price.  Each share of Preferred
               ----------------------------------
Stock shall be convertible, without the payment of any additional consideration
by the holder thereof and at the option of the holder thereof, at any time after
the date of issuance of such share, at the office of the Corporation or any
transfer agent for the Preferred Stock, into such number of fully paid and
nonassessable shares of Common Stock as is determined in accordance with the
following:

               (i)  in the case of the Series B Preferred Stock, by dividing
     $1.50 by the Series B Conversion Price, determined as hereinafter provided,
     in effect at the time of

                                      -3-
<PAGE>

     conversion. The Conversion Price at which shares of Common Stock shall be
     deliverable upon conversion of Series B Preferred Stock without the payment
     of any additional consideration by the holder thereof (the "Series B
     Conversion Price") shall initially be $1.50 per share of Common Stock. Such
     initial Series B Conversion Price shall be subject to adjustment, in order
     to adjust the number of shares of Common Stock into which the Series B
     Preferred Stock is convertible, as hereinafter provided.

               (ii) in the case of the Series A Preferred Stock, by dividing
     $0.50 by the Series A Conversion Price, determined as hereinafter provided,
     in effect at the time of conversion.  The Conversion Price at which shares
     of Common Stock shall be deliverable upon conversion of Series A Preferred
     Stock without the payment of any additional consideration by the holder
     thereof (the "Series A Conversion Price") shall initially be $0.50 per
     share of Common Stock.  Such initial Series A Conversion Price shall be
     subject to adjustment, in order to adjust the number of shares of Common
     Stock into which the Series A Preferred Stock in convertible, an
     hereinafter provided.

          (b)  Automatic Conversion.  Each share of Series B Preferred Stock
               --------------------
shall automatically be converted into shares of Common Stock at the applicable
Series B conversion Price than in effect upon:

               (i)  the closing of a firm commitment underwritten public
     offering pursuant to an effective registration statement under the
     Securities Act of 1933, as amended, covering the offer and sale of Common
     Stock for the account of the Corporation to the public at an offering price
     per share (prior to underwriter commissions and discounts) of not less than
     $4.50 (as adjusted pursuant to Subsection 2(e)(vi) hereof to reflect any
     stock dividends, distributions, combinations, reclassifications or other
     like transactions affected by the Corporation in respect of its Common
     Stock) and with gross proceeds to the Corporation of not less than
     $10,000,000 (in the event of which offering, the person(s) entitled to
     receive the Common Stock issuable upon such conversion of the Series B
     Preferred Stock shall not be deemed to have converted that Series B
     Preferred Stock until the closing of such offering); or

               (ii) the written election of the holders of not less than eighty-
     five percent (85%) of the then outstanding shares of the Series B Preferred
     Stock to require such mandatory conversion.

     Each share of Series A Preferred Stock shall automatically be converted
into shares of Common Stock at the applicable Series A Conversion Price then in
effect upon:

               (i)  the closing of a firm commitment underwritten public
     offering pursuant to an effective registration statement under the
     Securities Act of 1933, as amended, covering the offer and sale of Common
     Stock for the account of the Corporation to the public at an offering price
     per share (prior to underwriter commissions and discounts) of not less than
     $2.50 (as adjusted pursuant to Subsection 2(e)(vi) hereof to reflect any
     stock dividends, distributions, combinations, reclassifications or other
     like transactions affected by the Corporation in respect of its Common
     Stock) and with gross

                                      -4-
<PAGE>

     proceeds to the Corporation of not less than $10,000,000 (in the event of
     which offering, the person(s) entitled to receive the Common Stock issuable
     upon such conversion of the Series A Preferred Stock shall not be deemed to
     have converted that Series A Preferred Stock until the closing of such
     offering); or

               (ii) the written election of the holders of not less than eighty
     percent (80%) of the then outstanding shares of the Series A Preferred
     Stock to require such mandatory conversion.

          (c)  Mechanics of Automatic Conversions.  Upon the occurrence of an
               ----------------------------------
event specified in Subsection 2(b), the Series B Preferred Stock or the Series A
Preferred Stock, as applicable, or both, shall be converted automatically
without any further action by the holders of such shares and whether or not the
certificates representing such shares are surrendered to the Corporation or its
transfer agent; provided, however, that all holders of shares of Preferred Stock
being converted shall be given written notice of the occurrence of an event
specified in Subsection 2(b) including the date such event occurred (the
"Mandatory Conversion Date"), and the Corporation shall not be obligated to
issue certificates evidencing the shares of Common Stock issuable upon such
conversion unless certificates evidencing such shares of the Preferred Stock
being converted are either delivered to the Corporation or its transfer agent,
or the holder notifies the Corporation or any transfer agent that such
certificates have been lost, stolen, or destroyed and executes an agreement
satisfactory to the Corporation to indemnify the Corporation from any loss
incurred by it in connection therewith and, if the Corporation so elects,
provides an appropriate indemnity bond.  On the Mandatory Conversion Date, all
rights with respect to the Preferred Stock so converted shall terminate, except
any of the rights of the holder thereof, upon surrender of the holder's
certificate or certificates therefor, to receive certificates for the number of
shares of Common Stock into which such Preferred Stock has been converted,
together with cash in an amount equal to all dividends declared but unpaid on,
and any and all other amounts owing with respect to, the shares of Preferred
Stock converted to and including the time of conversion.  Upon the automatic
conversion of the Preferred Stock, the holders of such Preferred Stock shall
surrender the certificates representing such shares at the office of the
Corporation or of its transfer agent.  If so required by the Corporation,
certificates surrendered for conversion shall be endorsed or accompanied by
written instrument or instruments of transfer, in form satisfactory to the
Corporation, duly executed by the registered holder or by the holder's attorney
duly authorized in writing.  Upon surrender of such certificates there shall be
issued and delivered to such holder, promptly at such office and in the holder's
name as shown on such surrendered certificate or certificates, a certificate or
certificates for the number of shares of Common Stock into which the shares of
the Preferred Stock surrendered were convertible on the date on which such
automatic conversion occurred, together with cash in an amount equal to all
dividends declared but unpaid on, and any and all other amounts owing with
respect to, the shares of Preferred Stock converted to and including the time of
conversion.  No fractional share of Common Stock shall be issued upon the
mandatory conversion of the Preferred Stock.  In lieu of any fractional share to
which the holder would otherwise be entitled, the Corporation shall pay cash
equal to such fraction multiplied by the applicable Conversion Price then in
effect.

                                      -5-
<PAGE>

          (d)  Mechanics of Optional Conversions.  Before any holder of
               ---------------------------------
Preferred Stock shall be entitled to convert the same into shares of Common
Stock, the holder shall surrender the certificate or certificates therefor at
the office of the Corporation or of any transfer agent for the Preferred Stock,
and shall give written notice to the corporation at such office that the holder
elects to convert the same and shall state therein the holder's name or the name
or names of the holder's nominees in which the holder wishes the certificate or
certificates for shares of Common Stock to be issued. On the date of conversion,
all rights with respect to the Preferred Stock so converted shall terminate,
except any of the rights of the holder thereof, upon surrender of the holder's
certificate or certificates therefor, to receive certificates for the number of
shares of Common Stock into which such Preferred Stock has been converted and
cash in an amount equal to all dividends declared but unpaid thereon and any and
all other amounts owing with respect thereto at such time. If so required by the
Corporation, certificates surrendered for conversion shall be endorsed or
accompanied by written instrument or instruments of transfer, in form
satisfactory to the Corporation, duly executed by the registered holder or by
the holder's attorney duly authorized in writing. No fractional share of Common
Stock shall be issued upon the optional conversion of Preferred Stock. In lieu
of any fractional share to which the holder would otherwise be entitled, the
Corporation shall pay cash equal to such fraction multiplied by the applicable
Conversion Price then in effect. The Corporation shall, as soon as practicable
after surrender of the certificate or certificates for conversion, issue and
deliver at such office to such holder of Preferred Stock, or to the holder's
nominee or nominees, a certificate or certificates for the number of shares of
Common Stock to which the holder shall be entitled as aforesaid, together with
cash in lieu of any fraction of a share and cash in an amount equal to all
dividends declared but unpaid thereon and any and all other amounts owing with
respect thereto at such time. Such conversion shall be deemed to have been made
immediately prior to the close of business on the date of such surrender of the
shares of Preferred Stock to be converted, and the person or persons entitled to
receive the shares of Common Stock issuable upon conversion shall be treated for
all purposes as the record holder or holders of such shares of Common Stock on
such date.

          (e)  Adjustments to Conversion Price for Diluting Issues.
               ---------------------------------------------------

               (i)  Special Definitions.  For purposes of this Subsection 2(e),
                    -------------------
     the following definitions shall apply:

                    (1)  "Option" shall mean rights, options or warrants to
                          ------
          subscribe for, purchase or otherwise acquire either Common Stock or
          Convertible Securities.

                    (2)  "Original Issue Date" shall mean, with respect to the
                          -------------------
          Series A Preferred Stock, the first date on which a share of Series A
          Preferred Stock was issued, and shall mean, with respect to the Series
          B Preferred Stock, the first date on which a share of Series B
          Preferred Stock was issued.

                    (3)  "Convertible Securities" shall mean any evidences of
                          ----------------------
          indebtedness; shares of capital stock (other than Common Stock) or
          other

                                      -6-
<PAGE>

          securities directly or indirectly convertible into or exchangeable for
          Common Stock.

                    (4)  "Additional Shares of Common Stock" shall mean all
                          ---------------------------------
          shares of Common Stock issued (or, pursuant to Subsection 2(e)(iii),
          deemed to be issued) by the Corporation after the Original Issue Date,
          other than:

                         (A)  shares of Common Stock issued or issuable upon
               exercise of Options outstanding on the Original Issue Date;

                         (B)  up to 113,333 shares of Common Stock issuable upon
               conversion of shares of Series A Preferred Stock and Series B
               Preferred Stock issuable upon exercise of Options which may be
               issued in connection with equipment lease financing provided to
               the Corporation by Comdisco, Inc. or its affiliates;

                         (C)  up to 700,000 shares of Common Stock issued or
               issuable to officers or employees or directors of, or consultants
               to, the Corporation pursuant to a stock purchase or option plan
               or other employee stock bonus arrangement (collectively, the
               "Plans") approved by the Board of Directors;

                         (D)  shares of Common Stock issued or issuable upon
               conversion of shares of Series B Preferred Stock; and

                         (E)  shares of Common Stock issued or issuable upon
               conversion of shares of Series A Preferred Stock.

               (ii)   No Adjustment of Conversion Price.  Except as set forth in
                      ---------------------------------
     Subsection 2(e)(vi), no adjustment in the number of shares of Common Stock
     into which the Series B Preferred Stock or the Series A Preferred Stock is
     convertible shall be made, by adjustment in the applicable conversion Price
     in respect of the issuance of Additional Shares of Common Stock, unless the
     consideration per share for an Additional Share of Common Stock (determined
     pursuant to Subsection 2(a)(v)) issued or deemed to be issued by the
     Corporation is less than the applicable Conversion Price in effect on the
     date of, and immediately prior to, the issue of such Additional Share.

               (iii)  Issue of Securities Deemed Issue of Additional Shares of
                      --------------------------------------------------------
     Common Stock.
     ------------

                      (1)  Options and Convertible Securities.  In the event the
                           ----------------------------------
          Corporation at any time or from time to time after the Original Issue
          Date shall issue any Options or Convertible Securities or shall fix a
          record date for the determination of holders of any class of
          securities entitled to receive any such Options or Convertible
          Securities, then the maximum number of shares (as set forth in the
          instrument relating thereto without regard to any provisions contained

                                      -7-
<PAGE>

          therein for a subsequent adjustment of such number) of Common Stock
          issuable upon the exercise of such Options or, in the case of
          Convertible Securities and Options therefor, the conversion or
          exchange of such Convertible Securities, shall be deemed to be
          Additional Shares of Common Stock issued as of the time of such issue
          or, in case such a record date shall have been fixed, as of the close
          of business on such record date, provided that in any such case in
          which Additional Shares of Common Stock are deemed to be issued;

                         (A)   no further adjustment in the Series B Conversion
               Price or the Series A Conversion Price shall be made upon the
               subsequent issue of Convertible Securities or shares of Common
               Stock upon the exercise of such Options or conversion or exchange
               of such Convertible Securities;

                         (B)   if such Options or Convertible Securities by
               their terms provide, with the passage of time or otherwise, for
               any increase in the consideration payable to the Corporation, or
               decrease in the number of shares of Common Stock issuable, upon
               the exercise, conversion or exchange thereof, the Series B
               Conversion Price and the Series A Conversion Price computed upon
               the original issue thereof (or upon the occurrence of a record
               date with respect thereto), and any subsequent adjustments based
               thereon, shall, upon any such increase or decrease becoming
               effective, be recomputed to reflect such increase or decrease
               insofar as it affects such Options or the rights of conversion or
               exchange under such Convertible Securities;

                         (C)   upon the expiration of any such Options or any
               rights of conversion or exchange under such Convertible
               Securities which shall not have been exercised, the Series B
               Conversion Price and the Series A Conversion Price computed upon
               the original issue thereof (or upon the occurrence of a record
               date with respect thereto), and any subsequent adjustments based
               thereon, shall, upon such expiration, be recomputed as if:

                              (I)  In the case of Convertible Securities or
                    Options for Common Stock the only Additional Shares of
                    Common Stock issued were the shares of Common Stock, if any,
                    actually issued upon the exercise of such Options or the
                    conversion or exchange of such Convertible Securities and
                    the consideration received therefor was the consideration
                    actually received by the Corporation for the issue of all
                    such Options, whether or not exercised, plus the
                    consideration actually received by the Corporation upon such
                    exercise, or for the issue of all such Convertible
                    Securities which were actually converted or exchanged, plus
                    the additional consideration, if any, actually

                                      -8-
<PAGE>

                    received by the Corporation upon such conversion or
                    exchange; and

                              (II)     in the case of Options for Convertible
                    Securities only the Convertible Securities, if any, actually
                    issued upon the exercise thereof were issued at the time of
                    issue of such Options, and the consideration received by the
                    Corporation for the Additional Shares of Common Stock deemed
                    to have been then issued was the consideration actually
                    received by the Corporation for the issue of all such
                    Options, whether or not exercised, plus the consideration
                    deemed to have been received by the Corporation (determined
                    pursuant to Subsection 2(a)(v)) upon the issue of the
                    Convertible Securities with respect to which such Options
                    were actually exercised;

                         (D)  no readjustment pursuant to clause (B) or (C)
               above shall have the effect of increasing the Series B Conversion
               Price or the Series A Conversion Price to an amount which exceeds
               the lower of (i) the respective Conversion Price on the original
               adjustment date, or (ii) the respective Conversion Price that
               would have resulted from any issuance of Additional Shares of
               Common Stock between the original adjustment date and such
               readjustment date;

                         (E)  in the case of any Options which expire by their
               terms not more than 30 days after the date of issue thereof, no
               adjustment of the Series B Conversion Price or the Series A
               Conversion Price shall be made until the expiration or exercise
               of all such Options, whereupon such adjustment shall be made in
               the same manner provided in clause (C) above; and

                         (F)  if such record date shall have been fixed and such
               Options or Convertible Securities are not issued on the date
               fixed therefor, the adjustment previously made in the Series B
               Conversion Price and the Series A Conversion Price which became
               effective on such record date shall be cancelled as of the close
               of business on such record date, and thereafter the respective
               Conversion Prices shall be adjusted pursuant to this Subsection
               2(e)(iii) as of the actual date of their issuance.

                    (2)  Stock Dividends, Stock Distributions and Subdivisions.
                         -----------------------------------------------------
          In the event the Corporation at any time or from time to time after
          the Original Issue Date shall declare or pay any dividend or make any
          other distribution on the Common Stock payable in Common Stock or
          effect a subdivision of the outstanding shares of Common Stock (by
          reclassification or otherwise than by payment of a dividend in Common
          Stock), then and in any such events Additional Shares of Common Stock
          shall be deemed to have been issued:

                                      -9-
<PAGE>

                         (A)  in the case of any such dividend or distribution,
               immediately after the close of business on the record date for
               the determination of holders of any class of securities entitled
               to receive such dividend or distribution, or

                         (B)  in the case of any such subdivision, at the close
               of business on the date immediately prior to the date upon which
               such corporate action becomes effective.

                         If such record date shall have been fixed and no part
               of such dividend shall have been paid on the date fixed therefor,
               the adjustment previously made in the Series B Conversion Price
               and the Series A Conversion Price which became effective on such
               record date shall be cancelled as of the close of business on
               such record date, and thereafter the respective Conversion Prices
               shall be adjusted pursuant to this Section 2(e)(iii) as of the
               time of actual payment of such dividend.

               (iv)   Adjustment of Conversion Price Upon Issuance of Additional
                      ----------------------------------------------------------
     Shares of Common Stock.  In the event that at any time or from time to time
     ----------------------
     after the Original Issue Date, the Corporation shall issue Additional
     Shares of Common Stock (including, without limitation, Additional Shares of
     Common Stock deemed to be issued pursuant to Subsection 2(e)(iii)(1) but
     excluding Additional Shares of Common Stock deemed to be issued pursuant to
     Subsection 2(e)(iii)(2), which event is dealt with in Subsection
     2(e)(vi)(1)), without consideration or for a consideration per share less
     than the applicable Series B Conversion Price or Series A Conversion Price
     in effect on the date of and immediately prior to such issue, then and in
     such event, such Series B Conversion Price or Series A Conversion Price, as
     the case may be, shall be reduced, concurrently with such issue, to a price
     (calculated to the nearest cent) determined in accordance with the
     following formula:

                                     (P//1//) (Q//1//) + (P//2//) (Q//2//)
                             NCP  =  -------------------------------------
                                                Q//1// + Q//2//

     where:

               NCP      =    New Series B Conversion Price or Series A
                             Conversion Price, as applicable.

               P//1//   =    Series B Conversion Price or Series A Conversion
                             Price, an applicable, in effect immediately prior
                             to new issue.

               Q//1//   =    Number of shares of Common Stock outstanding, or
                             deemed to be outstanding as set forth below,
                             immediately prior to such issue.

                                     -10-
<PAGE>

               P//2//   =    Weighted average price per share received by the
                             Corporation upon such issue.

               Q//2//  =    Number of shares of Common Stock issued, or
                             deemed to have been issued, in the subject
                             transaction.

     provided that for the purpose of this Subsection 2(e)(iv), all shares of
     --------
     Common Stock issuable upon exercise or conversion of any Options or
     Convertible Securities outstanding immediately prior to such issue shall be
     deemed to be outstanding, and immediately after any Additional Shares of
     Common Stock are deemed issued pursuant to Subsection 2(e)(iii), such
     Additional Shares of Common Stock shall be deemed to be outstanding; and
     provided further, that the applicable Conversion Price shall not be so
     ----------------
     reduced at any time if the amount of such reduction would be an amount less
     than $.01, but any such amount shall be carried forward and reduction with
     respect thereto made at the time of and together with any subsequent
     reduction which, together with such amount and any other amount or amounts
     so carried forward, shall aggregate $.01 or more.

               (v)   Determination of Consideration.  For purposes of this
                     ------------------------------
     Subsection 2(e), the consideration received by the Corporation for the
     issue of any Additional Shares of Common Stock shall be computed as
     follows:

                    (1)  Cash and Property:  Such consideration shall:
                         -----------------

                         (A) insofar as it consists of cash, be computed at the
               aggregate amounts of cash received by the Corporation excluding
               amounts paid or payable for accrued interest or accrued
               dividends;

                         (B) insofar as it consists of property other than cash,
               be computed at the fair value thereof at the time of such issue,
               an determined in good faith by the Board of Directors; and

                         (C) in the event Additional Shares of Common Stock are
               issued together with other shares or securities or other assets
               of the Corporation for consideration which covers both, be the
               proportion of such consideration so received, computed as
               provided in clauses (A) and (B) above, as determined in good
               faith by the Board of Directors.

                    (2)  Options and Convertible Securities.  The consideration
                         ----------------------------------
          per share received by the Corporation for Additional Shares of Common
          Stock deemed to have been issued pursuant to Subsection 2(e)(iii)(1),
          relating to Options and Convertible Securities, shall be determined by
          dividing (x) the total amount, if any, received or receivable by the
          Corporation as consideration for the issue of such Options or
          Convertible Securities, plus the minimum aggregate amount of
          additional consideration (as set forth in the instruments relating
          thereto, without regard to any provision contained therein for a
          subsequent adjustment of

                                     -11-
<PAGE>

          such consideration) payable to the Corporation upon the exercise of
          such Options or the conversion or exchange of such Convertible
          Securities, or in the case of Options for Convertible Securities, the
          exercise of such Options for Convertible Securities and the conversion
          or exchange of such Convertible Securities, by (y) the maximum number
          of shares of Common Stock (as set forth in the instruments relating
          thereto, without regard to any provision contained therein for a
          subsequent adjustment of such number) issuable upon the exercise of
          such Options or the conversion or exchange of such Convertible
          Securities.

               (vi) Adjustment for Dividends, Distributions, Subdivisions,
                    ------------------------------------------------------
     Combinations or Consolidations of Common Stock.
     ----------------------------------------------

                    (1) Stock Dividends, Distributions or Subdivisions.  In the
                        ----------------------------------------------
          event the Corporation shall be deemed to issue Additional Shares of
          Common Stock pursuant to Subsection 2(e)(iii)(2) in a stock dividend,
          stock distribution or subdivision, the Series B Conversion Price and
          the Series A Conversion Price in effect immediately before such deemed
          issuance shall, concurrently with the effectiveness of such deemed
          issuance, be proportionately decreased.

                    (2) Combinations or Consolidations.  In the event the
                        ------------------------------
          outstanding shares of Common Stock shall be combined or consolidated,
          by reclassification or otherwise, into a lesser number of shares of
          Common Stock, the Series B Conversion Price and the Series A
          Conversion Price in effect immediately prior to such combination or
          consolidation shall, concurrently with the effectiveness of such
          combination or consolidation, be proportionately increased.

          (f) Adjustments for Certain Dividends and Distributions.  In the event
              ---------------------------------------------------
that at any time or from time to time after the Original Issue Date the
Corporation shall make or issue, or fix a record date for the determination of
holders of Common Stock entitled to receive, a dividend or other distribution
payable in securities of the Corporation other than shares of Common Stock, then
and in each such event provision shall be made so that the holders of Preferred
Stock shall receive upon conversion thereof in addition to the number of shares
of Common Stock receivable thereupon, the amount of securities of the
Corporation that they would have received had their Preferred Stock been
converted into Common Stock on the date of such event and had they thereafter,
during the period from the date of such event to and including the conversion
date, retained such securities receivable by them as aforesaid during such
period, giving application during such period to all adjustments called for
herein.

          (g) Adjustment for Reclassification, Exchange, or Substitution.  In
              ----------------------------------------------------------
the event that at any time or from time to time after the Original Issue Date,
the Common Stock issuable upon the conversion of Preferred Stock shall be
changed into the same or a different number of shares of any class or classes of
stock, whether by capital reorganization, reclassification, or otherwise (other
than a subdivision or combination of shares or stock dividend provided for
above, or a merger, consolidation, or sale of assets provided for below), then
and in each such event the holder of any share or shares of Preferred Stock
shall have the right thereafter to

                                     -12-
<PAGE>

convert such shares into the kind and amount of shares of stock and other
securities and property receivable upon such reorganization, reclassification,
or other change, by the holder of a number of shares of Common Stock equal to
the number of shares of Common Stock into which such shares of Preferred Stock
might have been converted immediately prior to such reorganization,
reclassification, or change, all subject to further adjustment as provided
herein.

          (h)  Adjustment for Merger, Consolidation or Sale of Assets.  In the
               ------------------------------------------------------
event that at any time or from time to time after the Original Issue Date, the
Corporation shall merge or consolidate with or into another entity or sell all
or substantially all of its assets, each share of Preferred Stock as to which
such consolidation, merger or sale is not treated as a liquidation under
Subsection 1(c) shall thereafter be convertible into the kind and amount of
shares of stock or other securities or property to which a holder of the number
of shares of Common Stock of the Corporation deliverable upon conversion of such
Preferred Stock would have been entitled to receive upon such consolidation,
merger or sale; and, in such case, appropriate adjustment (as determined in good
faith by the Board of Directors) shall be made in the application of the
provisions set forth in this Section 2 with respect to the rights and interest
thereafter of the holders of Preferred Stock, to the end that the provisions set
forth in this Section 2 (including provisions with respect to changes in and
other adjustments of the Conversion Price) shall thereafter be applicable, as
nearly as reasonably may be, in relation to any shares of stock or other
property thereafter deliverable upon the conversion of Preferred Stock.

          (i)  No Impairment.  The Corporation shall not, by amendment of its
               -------------
Certificate of Incorporation or through any reorganization, transfer of assets,
consolidation, merger, dissolution, issue or sale of securities or any other
voluntary action, avoid or seek to avoid the observance or performance of any of
the terms to be observed or performed hereunder by the Corporation but shall at
all times in good faith assist in the carrying out of all the provisions of this
Section 2 and in the taking of all such action as may be necessary or
appropriate in order to protect the Conversion Rights of the holders of
Preferred Stock against impairment.

          (j)  Certificate as to Adjustments.  Upon the occurrence of each
               -----------------------------
adjustment or readjustment of the Series B Conversion Price or the Series A
Conversion Price pursuant to this Section 2, the Corporation at its expense
shall promptly compute such adjustment or readjustment in accordance with the
terms hereof and furnish to each affected holder of Preferred Stock a
certificate setting forth such adjustment or readjustment and showing in detail
the facts upon which such adjustment or readjustment is based.  The Corporation
shall, upon the written request at any time of any affected holder of Preferred
Stock, furnish or cause to be furnished to such holder a like certificate
setting forth (i) such adjustments and readjustments, (ii) the Conversion Price
at the time in effect, and (iii) the number of shares of Common Stock and the
amount, if any, of other property which at the time would be received upon the
conversion of each share of Preferred Stock.

          (k)  Notices of Record Date.  In the event of any taking by the
               ----------------------
Corporation of a record of the holders of any class of securities for the
purpose of determining the holders thereof who are entitled to receive any
dividend (other than a cash dividend which is the same as cash dividends paid in
previous quarters) or other distribution, the Corporation shall mail to each

                                     -13-
<PAGE>

holder of Preferred Stock at least ten (10) days prior to such record date a
notice specifying the date on which any such record is to be taken for the
purpose of such dividend or distribution.

            (1)  Common Stock Reserved.  The Corporation shall reserve and keep
                 ---------------------
available out of its authorized but unissued Common Stock such number of shares
of Common Stock as shall from time to time be sufficient to effect conversion of
the Preferred Stock.

            (m)  Certain Taxes.  The Corporation shall pay any issue or transfer
                 -------------
taxes payable in connection with the conversion of Preferred Stock, provided,
however, that the Corporation shall not be required to pay any tax which may be
payable in respect of any transfer to a name other than that of the holder of
the Preferred Stock.

            (n)  Closing of Books.  The Corporation shall at no time close its
                 ----------------
transfer books against the transfer of any Preferred Stock or of any shares of
Common Stock issued or issuable upon the conversion of any shares of Preferred
Stock in any matter which interferes with the timely conversion or transfer of
such Preferred Stock or Common Stock.

Section 3.  Restrictions.
- ---------   ------------

            (a)     At any time when shares of Preferred Stock are outstanding,
except where the vote of the holders of a greater number of shares of the
corporation is required by law or by this Certificate of Incorporation, and in
addition to any other vote required by law or this Certificate of Incorporation,
without the affirmative vote of the holders of at least sixty percent (60%) of
the then outstanding shares of Preferred Stock (with calculations based upon the
number of shares of Common Stock into which such shares of Preferred Stock are
then convertible), voting collectively as a single class, the Corporation will
not:

                    (i)       consent to any liquidation, dissolution or winding
     up of the Corporation or merge or consolidate with or into any other entity
     or entities;

                    (ii)      sell, abandon, transfer, lease or otherwise
     dispose of all or any substantially portion of its properties and other
     assets; or

                    (iii)     amend this Certificate of Incorporation or the
     Corporation's By-Laws.

            (b)     At any time when shares of Series B Preferred Stock are
outstanding, except where the vote of the holders of a greater number of shares
of the Corporation is required by law or by this Certificate of Incorporation,
and in addition to any other vote required by law or this Certificate of
Incorporation, without the affirmative vote of the holders of at least eighty-
five percent (85%) of the then outstanding shares of Series B Convertible
Preferred Stock, the Corporation will not:

                    (i)       amend, alter or change the designation or any
     preferences, voting powers, qualifications, or special or relative rights
     or privileges of the Series B

                                     -14-
<PAGE>

     Convertible Preferred Stock in a manner adverse to the interests of the
     holders of the Series B Convertible Preferred Stock in any material
     respect;

                    (ii)      increase the authorized number of shares of Series
     B Preferred Stock;

                    (iii)     create or authorize the creation of any additional
     series of shares of stock unless such series ranks junior to the Series B
     Convertible Preferred Stock as to both dividends and the distribution of
     assets on the liquidation, dissolution, winding up or insolvency of the
     Corporation, or increase the authorized amount of any other class or series
     of shares of stock unless the same ranks junior to the Series B Convertible
     Preferred Stock as to dividends and the distribution of assets on the
     liquidation, dissolution, winding up or insolvency of the Corporation, or
     create or authorize any obligation or security convertible into shares of
     Series B Convertible Preferred Stock or into shares of any other class or
     series of shares of stock unless the same ranks junior to the Series B
     Convertible Preferred Stock as to dividends and the distribution of assets
     an the liquidation dissolution, winding up or insolvency of the
     Corporation, whether any such creation authorization or increase shall be
     by means of amendment to this Certificate of Incorporation or by merger,
     consolidation or otherwise.

          (c)       At any time when shares of Series A Preferred Stock are
outstanding, except where the vote of the holders of a greater number of shares
of the Corporation is required by law or by this Certificate of Incorporation,
and in addition to any other vote required by law or this Certificate of
Incorporation, without the affirmative vote of the holders of at least sixty
percent (60%) of the then outstanding shares of Series A Convertible Preferred
Stock, the Corporation will not:

                    (i)    amend, alter or change the designation or any
     preferences, voting powers, qualifications, or special or relative rights
     or privileges of the Series A Convertible Preferred Stock in a manner
     adverse to the interests of the holders of the Series A Convertible
     Preferred Stock in any material respect;

                    (ii)   increase the authorized number of shares of Series A
     Preferred Stock;

                    (iii)  create or authorize the creation of any additional
     series of shares of stock unless such series ranks junior to the Series A
     Convertible Preferred Stock as to both dividends and the distribution of
     assets on the liquidation, dissolution, winding up or insolvency of the
     Corporation, or increase the authorized amount of any other class or series
     of shares of stock unless the same ranks junior to the Series A Convertible
     Preferred Stock as to dividends and the distribution of assets on the
     liquidation, dissolution, winding up or insolvency of the Corporation, or
     create or authorize any obligation or security convertible into shares of
     Series A Convertible Preferred Stock or into shares of any other class or
     series of shares of stock unless the same ranks junior to the Series A
     Convertible Preferred Stock as to dividends and the distribution of assets
     on the liquidation, dissolution, winding up or insolvency of the
     Corporation, whether any

                                     -15-
<PAGE>

     such creation, authorization or increase shall be by means of amendment to
     this Certificate of Incorporation or by merger, consolidation or otherwise.

     Section 4.  Voting Rights.  Except as otherwise required by law or
     ----------  -------------
hereinafter set forth, the holders of Preferred Stock shall be entitled to
notice of any meeting of stockholders and shall vote together with the holders
of Common Stock an a single class upon any matter submitted to the stockholders
for a vote, on the following basis:

                 (a) Holders of Common Stock shall have one vote per share; and

                 (b) Holders of Preferred Stock shall have that number of votes
     per share as is equal to the number of shares of Common Stock (including
     fractions of a share) into which each such share of Preferred Stock held by
     such holder could be converted on the date for determination of
     stockholders entitled to vote at the meeting or on the date of any written
     consent.

     With respect to all questions as to which, under law, stockholders are
required to vote by classes, each of the Series A Preferred Stock and Series B
Preferred Stock shall vote separately as a single class apart from each other
and from the Common Stock.

     Section 5.  Dividends.
     ---------   ---------

            (a)  The holders of Series B Preferred Stock shall be entitled to
receive, from funds legally available therefor, a noncumulative dividend at the
rate of $.05 per share per annum, payable when and as declared by the Board of
Directors.  No dividends shall be declared or paid to the holders of Series A
Preferred Stock or Common Stock unless the holders of Series B Preferred Stock
have been paid in full all of the dividends to which they are entitled, nor
shall any dividends be declared or paid to the holders of Series A Preferred
Stock or Common Stock at a rate greater than the rate paid to the holders of
Series B Preferred Stock.

            (b)  Subject to Subsection 5(a), dividends may be declared and paid
on Series A Preferred Stock from funds lawfully available therefor as and when
determined by the Board of Directors of the Corporation. If, when and as
dividends are declared and paid on shares of Series A Preferred Stock, the
Corporation shall, after making payment in full to the holders of Series B
Preferred Stock the amounts to which they are entitled pursuant to Subsection
5(a), declare and pay at the same time to each holder of Series B Preferred
Stock, a dividend at the same rate, based on the number of shares of Common
Stock into which the Series B Preferred Stock and the Series A Preferred Stock
are convertible on the record date for the determination of holders of Series A
Preferred Stock entitled to receive such dividend.

            (c)  Subject to Subsection 5(a), dividends may be declared and paid
on Common Stock from funds lawfully available therefor as and when determined by
the Board of Directors of the Corporation. If, when and as dividends are
declared and paid on shares of Common Stock, the Corporation shall, after making
payment in full to the holders of Series B Preferred Stock the amounts to which
they are entitled pursuant to Subsection 5(a), declare and pay at the same time
to each holder of Preferred stock, a dividend equal to the dividend which

                                     -16-
<PAGE>

would have been payable to such holder if the shares of Preferred Stock hold by
such holder had been converted into Common Stock on the record date for the
determination of holders of Common Stock entitled to receive such dividend.

     Section 6.  Redemption.
     ---------   ----------

            (a)  In the event that the Corporation shall exercise its put option
to sell shares of capital stock of Sequenom Instruments GmbH to Technologie-
Beteiligungs-Gesellschaft mbH der Deutschen Ausgleichsbank ("TBG") pursuant to
that certain Kooperationsvertrag between the Corporation and TBG relating to the
investment by the Corporation of DM 3 million in Sequenom Instruments GmbH, the
Corporation shall, within 30 days after receipt of the proceeds of the sale of
such shares to the TBG, send notice of such exercise (the "Put Exercise Notice")
by first class mail, postage prepaid, to each holder of record of the Series B
Preferred Stock at its address as it appears on the books of the Corporation,
specifying (i) the amount of proceeds so received from the TBG net of any
expenses incurred in connection therewith (the "Put Net Proceeds"), (ii) the
date (the "Redemption Date") on which the Corporation will redeem shares of
Series B Preferred Stock from electing holders of the Series B Preferred Stock
in accordance with this Section 6, which Redemption Date shall be not less than
45 days nor more than 90 days after the date of such notice (the "Notice Date")
and (iii) each such holder's Pro Rata Redemption Amount (as hereinafter
defined).

            (b)  Each holder of Series B Preferred Stock may elect to have the
Corporation redeem from it on the Redemption Date, to the extent the Corporation
has funds legally available for such purpose, up to a number of shares of Series
B Preferred Stock equal to such holder's Pro Rata Redemption Amount (as
hereinafter defined) at a redemption price of $1.50 per share.  Such election
may be made only by delivering to the Corporation within thirty (30) days after
the Notice Date (i) a written election signed by such holder specifying the
number of shares of Series B Preferred Stock so to be redeemed (which number
shall be not more than such holder's Pro Rata Redemption Amount), and (ii)
certificates for the shares of Series B Preferred Stock so to be redeemed,
together with stock powers therefor duly executed by such holder in blank.

            (c)  For purposes of this Section 6, each holder of Series B
Preferred Stock's "Pro Rata Redemption Amount" shall be the greatest whole
number represented by a fraction, the numerator or which is the product of the
number of shares of Series B Preferred Stock held by such holder times the Put
Net Proceeds, and the denominator or which is the product of the total number of
shares of Series B Preferred Stock issued and outstanding times $1.50.

            (d)  On the Redemption Date the Corporation shall redeem from the
electing holders of Series B Preferred Stock the shares of Series B Preferred
Stock as to which election notices have been properly given, to the extent the
Corporation has funds legally available for such purpose.

            (e)  If the funds of the Corporation legally available for
redemption of shares of Series B Preferred Stock on the Redemption Date are
insufficient to redeem the total number of shares of Series B Preferred Stock
submitted for redemption, those funds which are legally available will be used
to redeem the maximum possible number of whole shares ratably among

                                     -17-
<PAGE>

the holders of such shares in accordance with the manner of determining the "Pro
Rata Redemption Amount" set forth above. The shares of Series B Preferred Stock
not redeemed shall remain outstanding and entitled to all rights and preferences
provided herein.

     Section 7. Residual Rights. All rights accruing to the outstanding shares
     ---------  ---------------
of the Corporation not expressly provided for to the contrary herein shall be
vested in the Common Stock.

                                     -18-
<PAGE>

                                  EXHIBIT 4.1
                                  -----------

         Foreign Qualification; Certificate of Incorporation; By-Laws
         ------------------------------------------------------------

     The Corporation is qualified to do business in Massachusetts.

     A certified copy of the Certificate of Incorporation (not including the
Certificate of Amendment contained in Exhibit 1) is included at Tab 9.

     A copy of the By-Laws is included as Exhibit A in Tab 7.
<PAGE>

                                  EXHIBIT 4.2
                                  -----------

                                Capitalization
                                --------------

     Attached-hereto is a stockholder list dated December 1, 1995.

     Also attached hereto is a common-equivalent capitalization table dated
December 14, 1995.
<PAGE>

                                SEQUENOM, INC.
                               Stockholder List
                               December 1, 1995

<TABLE>
<CAPTION>
AUTHORIZED:
                                Par Value             Authorized                 Issued
                              -------------       -----------------        ----------------
<S>                           <C>                 <C>                      <C>
Common:                           $.001                2,301,000                  148,251

Series A Convertible              $.00l                2,098,000                1,580,000
Preferred:
</TABLE>

                                 COMMON STOCK
                                 ------------

<TABLE>
<CAPTION>
Shareholder                       Shares             Cert. No.           Issue Date
- ---------------------         --------------      ---------------     -----------------
<S>                           <C>                 <C>                 <C>
Hubert Koster                         1                C-10                03-08-95
Stapelstrasse 56
D-22529
Hamburg, Germany

***                              90,000                C-11                10-16-95

***                              26,250                C-12                10-31-95

***                              10,000                C-13                12-01-95

Helmut Schuhsler                 10,000                C-14                12-01-95

Patricia Dane                     2,000                C-15                12-01-95

Amy B. Crawford                   2,000                C-16                12-01-95

Monica Schlawinsky                2,000                C-17                12-01-95

John J. DiBello                   6,000                C-18                12-01-95
</TABLE>

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                     SERIES A CONVERTIBLE PREFERRED STOCK
                     ------------------------------------

<TABLE>
<CAPTION>
Shareholder                       Shares              Cert. No.               Issue Date
- ------------------------      --------------      -----------------       ------------------
<S>                           <C>                 <C>                     <C>
Hubert Koster                    1,120,000                    1                 03-08-95
Stapelstrasse 56
D-22529
Hamburg, Germany

***                                 40,000                    2                 03-08-95

***                                 20,000                    3                 03-08-95

TVM Techno Venture                   8,000                   10                 08-18-95
Investors No. 1 Limited
  Partnership
101 Arch Street
Suits 1950
Boston, MA 02110

TVM Techno Venture                  63,680                   12                 08-18-95
Enterprises No. II Limited
Partnership
101 Arch Street
Suite 1950
Boston, MA 02110

TVM Intertech Limited               42,454                   13                 08-18-95
Partnership
101 Arch Street
Suite 1950
Boston, MA 02110

TVM Zweite Beteiligung-             98,000                    6                 03-08-95
  U.S. Limited Partnership          29,360                   11                 08-18-95
101 Arch Street
Suite 1950
Boston, MA 02110

TVM Eurotech Limited                65,200                    7                 03-08-95
  Partnership                       19,706                    9                 08-18-95
101 Arch Street
Suite 1950
Boston, MA 02110

***                                 73,600                    8                 03-08-95
</TABLE>
***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

Sequenom, Inc.
Analysis of shares and options issued
December 14, 1996-before financing

<TABLE>
<CAPTION>
                                                                                                                  Shares to be
                                                         Shares issued for  Shares issued through  Total shares   issued under
                                                Shares       service of         exercise of         issued and     options or
                                              purchased      technology        stock options        outstanding     warrants
                                              ---------  -----------------  ---------------------  ------------   ------------
<S>                                           <C>        <C>                <C>                    <C>            <C>
Founders:
- ---------
Koster                                         20,001       1,100,000                                1,120,001        80,000
***                                             2,000          38,000              90,000              130,000
***                                            20,000                                                   20,000        30,000
                                              --------------------------------------------------------------------------------
Founder Subtotal                               42,001       1,138,000              90,000            1,270,001       110,000
                                              --------------------------------------------------------------------------------
TVM entities:
TVM Techno Venture Enterprises
No. II L.P.                                   _______                                                _________
TVM Intertech L.P.                             42,454                                                   42,454
TVM Eurotech L.P.                              84,906                                                   84,906
TVM Zweite Beteiligung US L.P.                127,380                                                  127,380
TVM Techno Venture Investors                    8,000                                                    8,000
  No. I L.P.
***                                            73,000                                                   73,000
                                              --------------------------------------------------------------------------------
TVM Subtotal                                  400,000               0                   0              400,000             0
                                              --------------------------------------------------------------------------------
Other shares Issued:
- --------------------
Russell Hays                                    28250                                                    28250
Helmut Schuhsler                                               10,000                                   10,000
Randall Lunn                                                   10,000                                   10,000
John J. DiBello                                                 6,000                                    6,000
Monica Schlawinsky                                              2,000                                    2,000
Amy B. Crawford                                                 2,000                                    2,000
Patricia Dane                                                   2,000                                    2,000
                                              --------------------------------------------------------------------------------
Other subtotal                                  28250          32,000                   0               58,250             0
                                              --------------------------------------------------------------------------------
                                              --------------------------------------------------------------------------------
Total shares issued as of December 14, 1995   488,251       1,170,000             $90,000            1,278,251       110,000
                                              --------------------------------------------------------------------------------

Options and warrants outstanding:
- ---------------------------------
***                                                                                                                    42000
Charles Cantor (technical advisory board)                                                                            _______
***                                                                                                                    10000
***                                                                                                                    10000
***                                                                                                                    10000

________ warrants:                                                                                                     70000
***                                                                                                                    43333
***

                                              --------------------------------------------------------------------------------
Total options and warrants outstanding                                                                               251,333
                                              --------------------------------------------------------------------------------

Fully diluted total as of December 14, 1995   488,251       1,170,000              90,000            1,728,251       361,333
                                              --------------------------------------------------------------------------------
<CAPTION>
                                                  Total shares       Fully Diluted
                                                Issued and under       Percentage
                                                Options/warrants       Ownership
                                                ----------------     -------------
Founders:
- ---------
<S>                                             <C>                  <C>
Koster                                              1,200,001            57.43%
***                                                   130,000             6.22%
***                                                    50,000             2.30%
                                                ----------------------------------
Founder Subtotal                                    1,380,000            86.04%
                                                ----------------------------------
TVM entities:
TVM Techno Venture Enterprises                      _________             3.05%
No. II L.P.
TVM Intertech L.P.                                     42,454             2.03%
TVM Eurotech L.P.                                   _________             4.08%
TVM Zweite Beteiligung US L.P.                        127,380            _____%
TVM Techno Venture Investors                            8,000             0.38%
  No. I L.P.
***                                                    73,000             3.62%
                                                ----------------------------------
TVM Subtotal                                          400,000            19.14%
                                                ----------------------------------
Other shares Issued:
- --------------------
Russell Hays                                            28250            1.2__%
Helmut Schuhsler                                       10,000            _____%
Randall Lunn                                           10,000            _____%
John J. DiBello                                         6,000           0.2___%
Monica Schlawinsky                                      2,000             0.10%
Amy B. Crawford                                         2,000             0.10%
Patricia Dane                                           2,000             0.10%
                                                ----------------------------------
Other subtotal                                         58,250             2.79%
                                                ----------------------------------
                                                -----------------------
Total shares issued as of December 14, 1995         1,636,251
                                                -----------------------

Options and warrants outstanding:
- ---------------------------------
***                                                    42,000              2.01%
Charles Cantor                                      _________              3.16%
***                                                    10,000              0.48%
***                                                    10,000              0.48%
***                                                    10,000              0.48%

________ warrants:
***                                                    70,000              3.35%
***                                                    43,333              2.07%

                                                ----------------------------------
Total options and warrants outstanding                251,333             12.03%
                                                ----------------------------------

Fully diluted  total as of December 14, 1995        2,089,564            100.00%
                                                ----------------------------------
</TABLE>

* Warrants not yet issued
<PAGE>

                                  EXHIBIT 4.3
                                  -----------

                              Equity Investments
                              ------------------

     The Corporation has one subsidiary, Sequenom Instruments GmbH, all of the
outstanding equity interest in which is owned by the corporation.
<PAGE>

                                 EXHIBIT 4.4A
                                 ------------

                        Unaudited Financial Statements
                          as of December 31, 1994 and
                              for the year ended
                        ------------------------------
<PAGE>

- --------------------------------------------------------------------------------

                                 SEQUENOM, INC
                       (A Development Stage Enterprise)
- --------------------------------------------------------------------------------

                          CONSOLIDATED BALANCE SHEET
                               December 31, 1994
                                    ASSETS

<TABLE>
          <S>                                                    <C>
          Cash                                                        ***
          Other current assets                                        ***
                                                                 -------------
             Total current assets                                     ***
                                                                 -------------
          Office equipment                                            ***
          Less accumulated depreciation                               ***
                                                                 -------------
                                                                      ***
                                                                 -------------
          Organizational costs (net accumulated                       ***
             amortization of $6,000)
          Other assets                                                ***
                                                                 -------------
          Total assets                                                ***
                                                                 -------------
                               LIABILITIES
          Convertible term notes                                      ***
          Accrued expenses                                            ***
                                                                 -------------
          Total Liabilities                                           ***
                                                                 -------------
                               STOCKHOLDERS' DEFICIT
          Series A Convertible Preferred Stock                        ***
          Common Stock                                                ***
          Cumulative translation adjustment                           ***
          Deficit accumulated in the development stage                ***
                                                                 -------------
          Total stockholder's deficit                                 ***
                                                                 -------------
          Total liabilities and stockholders' deficit                 ***
                                                                 =============
</TABLE>

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

- --------------------------------------------------------------------------------

                                 SEQUENOM, INC
                       (A Development Stage Enterprise)
- --------------------------------------------------------------------------------

                     CONSOLIDATED STATEMENT OF OPERATIONS
  From the period of inception (February 14, 1994) through December 31, 1994

<TABLE>
          <S>                                                   <C>
          Operating Expenses:
             Research and development                                ***
             General and administrative                              ***
                                                                --------------
                                                                     ***
                                                                --------------
          Net Operating loss from Operations                         ***
          Interest Income                                            ***
          Net loss                                                   ***
                                                                ==============
</TABLE>

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                 EXHIBIT 4.4B
                                 ------------

                        Unaudited Financial Statements
                          as of October 31, 1995 and
                         for the ten-months then ended
                    --------------------------------------
<PAGE>

- --------------------------------------------------------------------------------
                                 SEQUENOM, INC
                        (A Development Stage Enterprise)
- --------------------------------------------------------------------------------

                           CONSOLIDATED BALANCE SHEET
                                October 31, 1995
ASSETS
                                                              10/31/95
                                                             ----------
                cash                                              ***
                Prepaid expenses                                  ***
                Other current assets                              ***
                Accounts receivable                               ***
                Other assets                                      ***
                Fixed assets (net accumulated depreciation of
                $629)                                             ***
                Organizational costs (net accumulated
                amortization of $12,667)                          ***
                                                             ----------
                Total assets                                      ***
                                                             ==========

LIABILITIES
                Accounts Payable and Accrued Expenses             ***
                Convertible term notes                            ***
                Silent Partnership loan                           ***
                Total Liabilities                                 ***
                                                             ----------
                  STOCKHOLDERS' DEFICIT

                Series A Convertible Preferred Stock              ***
                Common Stock                                      ***
                Cumulative translation adjustment                 ***
                Deficit accumulated in the development stage      ***
                                                             ----------
                Total stockholder's deficit                       ***
                                                             ----------
                Total liabilities and stockholders' deficit       ***
                                                             ==========

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

- --------------------------------------------------------------------------------
                                 SEQUENOM, INC
                       (A Development Stage Enterprise)
- --------------------------------------------------------------------------------

                     CONSOLIDATED STATEMENT OF OPERATIONS
                     For the period ended October 31, 1995
                                                              10/31/95
Operating Expenses:                                          ----------
     Consulting fees                                              ***
     Travel expenses                                              ***
     Amortization expense                                         ***
     Depreciation expense                                         ***
     Audit fees                                                   ***
     Legal & Tax                                                  ***
     Recruitment expense                                          ***
     Advisory fees                                                ***
     unrealized f(x) loss                                         ***
     General and administrative expenses                          ***
                                                             ----------
                                                                  ***
                                                             ----------

Net Operating loss from Operations                                ***
Interest Income                                                   ***
Net loss                                                          ***
                                                             ==========


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                  EXHIBIT 4.5

                            Undisclosed Liabilities
                            -----------------------

None.
<PAGE>

                                  EXHIBIT 4.6
                                  -----------

                        Changes Since October 31, 1995
                        ------------------------------

     The Corporation has received bridge loans from certain of the Investors
since October 31, 1995 as follows:

                Date                                 Amount
             ---------                             ---------

       November 1, 1995                             $ 18,400
       November 10-21, 1995                          100,000
       November 30, 1995                             100,000
                                                 --------------
         Total                                      $218,400
<PAGE>

                                  EXHIBIT 4.7
                                  -----------

                                 Encumbrances
                                 ------------

     None, other than non-consensual liens arising in the ordinary course of
business by operation of law.  The Corporation is not aware of the existence of
any such liens.
<PAGE>

                                 EXHIBIT 4 - 8
                                 -------------

                         Intellectual Property Rights;
                          Agreements with Dr. Koster
                          --------------------------


     Attached hereto is a patent status sheet dated December 8, 1995.

     Also attached hereto are copies of the Assignment of Inventions dated May
26, 1994, Executive Employment Agreement dated as of April 1, 1994 and
Consulting Services Agreement dated April 1, 1994 between the Corporation and
Dr. Hubert Koster.
<PAGE>

Page 1                                                          (as of 12/08/95)

      SEQUENOM PATENT STATUS SHEET AND PROJECTED 1996 PATENT COSTS (U.S.)
      -------------------------------------------------------------------


                                     ***


   *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

Page 2                                                          (as of 12/08/95)

      SEQUENOM PATENT STATUS SHEET AND PROJECTED 1996 PATENT COSTS (U.S.)
      -------------------------------------------------------------------


                                     ***


*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                      36


<PAGE>

Page 3                                                          (as of 12/08/95)

      SEQUENOM PATENT STATUS SHEET AND PROJECTED 1996 PATENT COSTS (U.S.)
      -------------------------------------------------------------------


                                     ***


*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                      37
<PAGE>

Page 4                                                          (as of 12/08/95)

      SEQUENOM PATENT STATUS SHEET AND PROJECTED 1996 PATENT COSTS (U.S.)
      -------------------------------------------------------------------



                                     ***

***  Portions of this page have been omitted pursuant to a request for
     Confidential Treatment and filed separately with the Commission.

                                      38.
<PAGE>

Page 5                                                          (as of 12/08/95)

                         SEQUENOM SUBJECT MATTER SHEET
                         -----------------------------



                                     ***


***  Portions of this page have been omitted pursuant to a request for
     Confidential Treatment and filed separately with the Commission.

                                      39.
<PAGE>

                           ASSIGNMENT OF INVENTIONS
                           ------------------------


          This Assignment of Inventions (the "Assignment") is made as of May 26,
1994, by and between SEQUENOM, INC., a Delaware corporation (the "Company"), and
Dr. Hubert Koster (the "Assignor") having a place of business at 1640 Monument
Street, Concord, MA 01742.

                               R E C I T A L S:
                               ---------------

          A.   Prior to the date hereof, Assignor has been developing certain
technology and products to determine DNA sequencing by mass spectrometry (the
"Products");

          B.   Assignor desires to transfer to the Company all intellectual
property related to the Products, and to cancel certain expenses incurred in
connection with the development thereof, in exchange for the issuance of Common
Stock of the Company; and

          C.   Assignor and the Company intend the foregoing transaction to
qualify as a non-taxable transfer within the meaning of Section 351 of the
Internal Revenue Code of 1986, as amended, in that such transfer will be made
solely in exchange for Common Stock of the Company and immediately thereafter
Assignor will be in control of the Company.

          NOW, THEREFORE, in consideration of the foregoing and the mutual
promises contained herein, the parties agree as follows:

          1.   The recitals set forth above shall be deemed to be a part of this
Agreement as though such provisions had been forth in full in this Agreement.

          2.   In consideration of the issuance of 1,100,000 shares of the
Common Stock of the Company, Assignor hereby assigns to the Company all of his
right, title and interest in and to (i) all inventions and improvements,
designs, know-how, and ideas (including all patents, trademarks, trade names,
copyrights, inventions, trade secrets, proprietary processes and
<PAGE>

formulae, applications for patents, trademarks and copyrights, and other
industrial and intellectual property rights) relating to the Products, including
but not limited to the United States Patent and Trademark Applications and
inventions described on Exhibit A hereto, and (ii) all machines, instruments,
devices, equipment or models incident or related thereto, made, conceived, or
created by Assignor prior to the date of this Assignment, all of which are
hereafter referred to as the "Inventions." This Assignment is intended to
include any additional rights in or to the Inventions received by Assignor after
the effective date of this Assignment, without further consideration to
Assignor, including rights to any credits and royalties arising out of the
Inventions. Assignor further waives and relinquishes his tight to request any
reimbursement by the Company of expenses incurred by or on behalf of Assignor
prior to the date hereof in connection with the development of the Products or
the Inventions.

          3.   Assignor represents and warrants that he has made no prior
license, transfer, assignment or hypothecation of any interest in the Inventions
and that no other person or firm has any interest in the Patent and Patent
Applications and the trademark Application listed in Exhibit A hereto and to the
best of Assignor's knowledge in any other Inventions.  Assignor owns, possesses,
and has the right to use, to bring actions for the infringement of and to
transfer and assign to the Company the Patent and Patent Applications and the
Trademark Application listed in Exhibit A hereto and to the best of Assignor's
knowledge all other Inventions.  No royalties or other amounts will be payable
by the Company to Assignor by reason of its ownership, use or licensing of the
Inventions.  To the best of Assignor's knowledge, no Invention violates any
license or infringes any patent, copyright, trademark, trade secret or other
intellectual property right of any person or entity, nor will royalties or other
amounts be payable by the Company to any person or entity by reason of the
Company's ownership, use or licensing

                                      2.
<PAGE>

of the Inventions, nor is there any reasonable basis to believe that any such
violation, infringement or conflict may exist, except that Assignor is aware of,
and hereby gives the Company notice of, U.S. Patent No. 5,288,644 issued on
February 22, 1994 to Rockefeller University (Inventors R.C. Beavis and B.T.
Chait) and now in the possession of Perceptive Biosystems, Cambridge,
Massachusetts. Assignor has not received any notice that any of such Inventions
or the-ownership, use or licensing thereof in the operation or proposed
operation of the Company's business conflicts with the rights of others.
Assignor owns all right, title and interest in and to the Patent and Trademark
Applications described on Exhibit A hereto.

          4.   In support of said Assignment, Assignor further agrees as
follows:

               (a)  To deliver to the company copies of all writings and other
tangible evidence or representations of the Inventions, and any improvements
covered by this Assignment;

               (b)  To execute such additional documents as may reasonably be
required to transfer to the Company Assignor's entire right, title and interest
in or to the Inventions, improvements thereof covered by this Assignment and to
all rights of priority thereto pursuant to the International Convention for
Protection of Industrial Property; and in and to any and all Letters Patent on
said Inventions and/or said improvements that may be granted in the United
States or any foreign country, including each and every Letter Patent granted on
any application which is a division, substitution, or continuation of said
application specifically identified herein, and in and to each and every reissue
or extension of said Letters Patent;

               (c)  Not to make any use of the Inventions or improvements
covered by this Assignment for his benefit or interest and to hold them in
confidence and not to disclose

                                      3.
<PAGE>

them to anyone other than personnel of the Company, without the prior written
consent of an officer of the Company;

               (d)  To cooperate with the company whereby said company may enjoy
to the fullest extent the right, title and interest herein conveyed. Such
cooperation shall include: (i) prompt execution of all papers (prepared at the
expense of the Company) which are deemed necessary or desirable by the Company
to perfect in it the right, title and interest herein conveyed; (ii) prompt
execution of all petitions, oaths, specifications, declarations or other papers
(prepared at the expense of the Company) which are deemed necessary or desirable
by the Company for prosecuting said applications specifically identified herein,
for filing and prosecuting substitutions, divisions, continuing or additional
applications in the United States and/or foreign countries covering said
Inventions and/or said improvements, for filing and prosecuting applications for
reissuance of Letters Patent included herein, or for interference (i.e.,
priority) proceedings involving said Inventions and/or said improvements; and
(iii) prompt assistance and cooperation in the prosecution of legal proceedings
involving said Inventions and/or said improvements, said applications and
patents granted thereon, including oppositions, cancellation proceedings,
priority contests, public use proceedings and court actions; provided, however,
that any expense which may be incurred by Assignor in lending such assistance
and cooperation shall be paid by the Company.

          5.   This Assignment shall constitute the Company as the owner of the
Inventions as of May 26, 1994 and all tangible representations thereof, without
the requirement of further delivery; provided, however, that if by September 1,
1994 the Company has not received aggregate gross proceeds of at least Five
Million Dollars ($5,000,000.00) from financings on terms no less favorable to
the Company than those set forth in a Memorandum of

                                      4.
<PAGE>

Terms for a Private Placement of Preferred Stock dated March 28, 1994, despite
Assignor's best efforts to assist the Company in obtaining such financing
Assignor shall have the option (the "Option"), exercisable by delivery of a
written election to the Company on or before October 1, 1994, to declare the
assignment and transfer of the Inventions pursuant to this Assignment of
Inventions null and void. On receipt of Assignor's election to exercise the
Option to declare the assignment and transfer of the Inventions null and void,
the Company shall: (a) deliver to Assignor copies of all materials provided to
the company by Assignor pursuant to Paragraph 4 above; (b) execute and deliver
to Assignor such additional documents as may reasonably be required to transfer
to Assignor the Company's entire right, title, and interest in or to the
Inventions; and (c) cease making any use of the Inventions or improvements
covered by this Assignment of Inventions.

          6.   This Assignment of Inventions shall be binding on all of the
heirs and assigns of Assignor, and shall inure to the benefit of the Company,
its assigns and successors.

          7.   This Assignment of Inventions shall be governed by and construed
in accordance with the laws of the Commonwealth of Massachusetts, U.S.A.,
without application of principles of conflicts of laws.

          EXECUTED this 26th day of May, 1994.

                                        /s/ Hubert Koster
                                        --------------------------------
                                        Hubert Koster

                                        SEQUENOM, INC.


                                        By: /s/ Nola E. Masterson
                                           -----------------------------

                                        Title:  CEO
                                              --------------------------

                                      5.
<PAGE>

                                   EXHIBIT A
                                   ---------

                                  INVENTIONS


                                                         U.S. Patent or
                                                       Patent Application
Description                                             Number of Status
- -----------                                             ----------------

1.   "DNA Sequencing by                           Serial No. 08/001,323 (filed
     Mass Spectroscopy"                           January 7, 1993)

                                                  Continuation-in-Part, Serial
                                                  No. 08/178,216 (filed
                                                  January 6, 1994)

                                                  PCT-Application, Serial No.
                                                  PCT/US94/00192 (filed
                                                  January 6, 1994)

2.   "DNA Sequencing by                           Serial No. 08/034,738 (filed
     Mass Spectroscopy                            March 19, 1993)
     via Exonuclease
     Degradation"

                                                  PCT-Application, Serial No.
                                                  PCT/US94/02938 (filed
                                                  March 18, 1994)

     Filings for both of the patent applications have been made in the following
countries: Austria, Belgium, Switzerland/Liechtenstein, Germany, Denmark, Spain,
France, United Kingdom, Greece, Ireland, Italy, Luxembourg, Monaco, Netherlands,
Portugal, Sweden, Australia, Canada, China, Japan and the Russian Federation.



                                   TRADEMARK

                                                     U.S. Trademark
                                                    Application Number
                                                       or Status
                                                  -----------------------------
1.  SEQUENOM                                       Serial No. 74/347,804
                                                   (Notice of Allowance issued
                                                   12/7/93)
<PAGE>

                               CONSENT OF SPOUSE


               I, Jutta Koster, spouse of Hubert Koster, agree that my interest
     in the Inventions subject to the foregoing Assignment of Inventions shall
     be irrevocably bound by the terms thereof.  I further understand and agree
     that my community property interest, if any, shall be similarly bound by
     said Assignment, that such consent is binding upon my heirs, personal
     representatives and assigns, and I agree to execute and deliver such
     documents as may be necessary to carry out the intent of this Agreement.

Date:  May 26, 1994

                                        /s/ Jutta Koster
                                       --------------------------------
                                       Jutta Koster
<PAGE>

                        EXECUTIVE EMPLOYMENT AGREEMENT
                        ------------------------------


     This Executive Employment Agreement (the "Agreement") is dated as of April
1, 1994 between Sequenom, Inc. (the "Company"), a Delaware corporation, and Dr.
Hubert Koster (the "Executive") currently residing at Stapelstr. 5b, 22529
Hamburg, Germany.


                             ARTICLE 1. RECITALS

     1.1.  Development of Technologies.  Executive has developed certain
           ---------------------------
technologies related to DNA sequencing by mass spectrometry (the "Technologies")
and, in connection with the founding of the Company, has assigned to the Company
all patent applications, technological developments and trademarks owned or
controlled by him which are related to the Technologies.

     1.2.  Employment of Executive.  Executive is currently a Professor at the
           -----------------------
University of Hamburg (the 'University") in Germany.  The Company wishes to
secure the services of Executive as a key employee of the Company to facilitate
the transfer of the Technologies to the Company, to develop products based on
the Technologies and to obtain the benefit of Executive's vision for the long
range development of the Technologies and the business of the Company.
Executive is willing to become an employee of the Company commencing on the date
(the "Effective Date") he is permitted to do so under the terms of his
arrangement with the University.


                      ARTICLE 2. EMPLOYMENT OF EXECUTIVE

     2.1.  Employment.  Subject to the terms and conditions of this Agreement,
           ----------
the Company agrees to employ Executive in a full time capacity to serve as
Executive Vice President, Science & Operations and Chief Technical Officer.  The
duties of Executive shall include directing the research, development and
engineering activities of the Company, being responsible for long range
technological planning, assisting other officers of the Company in establishing
marketing objectives and strategic plans for overall business development, and
performing such other specific duties as may reasonably be assigned to the
Executive from time to time by the Board of Directors of the Company.  Executive
hereby accepts such employment for the term hereof.

     2.2.  Term.  Executive's employment under this Agreement shall be for an
           ----
initial term commencing on the Effective Date and terminating three (3) years
from such date, unless earlier terminated as herein provided.  The term of this
Agreement may be extended beyond the initial term by mutual written consent.

     2 3.  No Conflicting Commitments.  During the period of the Executive's
           --------------------------
full time employment with the Company, Executive will not undertake any
Commitments which might impair Executive's performance of his duties as a full
time employee of the Company.  Notwithstanding the foregoing, (i) Executive
shall be permitted to continue his consulting
<PAGE>

relationship with Hybridon, Inc., including an extensions thereof. and to retain
all payments received thereunder and (ii) Executive shall be entitled to
maintain in affiliations with one or more universities in Hamburg and Boston on
the understanding that such relationships will advance the interests of the
Company by permitting Executive to utilize facilities, equipment and research
personnel in areas of research which are of interest to the Company. Without
limiting the generality of the foregoing, the Company acknowledges and
understands that (i) during a transition period, Executive will direct the
efforts of some scientists. diploma and Ph.D. students working at the University
as they finish their research topics; (ii) Executive may continue to act as a
principal investigator, in collaboration with colleagues at other German
universities and with certain German scientific instrument manufacturers, under
a grant from the German Ministry of Research and Technology extending through
June 30, 1996, and (iii) Executive may act as a principal investigator under a
potential grant from the Deutsche Forschungsgemeinschaft entitled "Use of MALDI-
TOF and Electrospray Mass Spectrometry in the Analysis of Nucleic Acids.'
Executive's consulting relationship and university affiliations are expected to
consume less than ten percent (10%) of Executive's productive time.

                            ARTICLE 3. COMPENSATION

     For all services to be rendered by Executive to the Company pursuant to
this Agreement, the Company shall pay to the Executive the compensation and
provide for Executive the benefits set forth below:

     3.1.  Base Salary.  The Company shall pay to Executive a base salary at the
           -----------
rate of $170,000 per annum during the initial twelve (12) months of this
Agreement. prorated and payable in substantially equal monthly installments.
Executive's salary will be reviewed annually and may be increased (but not
reduced) by the Board of Directors of the Company or a duly appointed committee
thereof.

     3.2.  Relocation Expenses.  The Company shall reimburse Executive all
           -------------------
moving expenses incurred in moving his family and household goods to the Boston,
Massachusetts area, up to a maximum of $40,000.

     3.3.  Bonuses.  Executive shall be entitled to receive a cash bonus of
           -------
$10,000 payable when the Company hires its first full-time Chief Executive
Officer.

     3.4.  Fringe Benefits.  In addition to Executive's base salary, relocation
           ---------------
expenses and bonuses, the Company shall provide Executive and Executive's
dependents medical insurance and such other benefits as are generally made
available by the Company to its other full time executive employees.


                         ARTICLE 4. EARLY TERMINATION

     4.1.  Early Termination.  Executive's employment hereunder shall terminate
           -----------------
prior to the expiration of the terms of this Agreement upon the occurrence of
any of the following events:

                                      -2-
<PAGE>

           4.1.1.  Executive's death or legal incapacity; or

           4.1.2.  The termination of Executive's employment hereunder by the
     Board of Directors of the Company, at its option, to be exercised by
     written notice to Executive. upon Executive's other incapacity or inability
     to further perform services as contemplated herein for a period aggregating
     90 days or more within any six-month period because Executive's physical or
     mental health shall have become impaired so as w make it impossible or
     impractical to perform the duties and responsibilities contemplated
     hereunder; or

           4.1.3.  The termination of Executive's employment hereunder by the
     Board of Directors of the Company, at its option, to be exercised by
     written notice to Executive, in the event of Executive's gross neglect of
     his duties hereunder, the commission by Executive of an act of deliberate
     dishonesty or moral turpitude in connection with his employment or the
     material breach by Executive of any obligation under this Agreement or any
     other agreement between Executive and the Company; or

           4.1.4.  The termination of Executive's employment hereunder by the
     Board of Directors of the Company, at its option which may be exercised
     with or without cause, to be exercised by delivery of written notice from
     the Company to the Executive; or

           4.1.5.  The termination of Executive's employment hereunder by
     Executive to be exercised by delivery of written notice from Executive to
     the Company.

     4.2.  Adjustments Upon Early Termination.  Notwithstanding any other
           ----------------------------------
provisions in this Agreement to the contrary:

           4.2.1.  If Executive's employment with the Company terminates
     pursuant to Section 4.1.1. or 4.1.2., all payments and benefits provided to
     Executive under this Agreement shall cease as of the date of termination of
     employment.

           4.2.2.  If Executive's employment with the Company terminates
     pursuant to Section 4.1.3. or 4.1.5., all payments and benefits provided to
     Executive under this Agreement shall cease as of the date of termination of
     employment.

           4.2.3.  If Executive's employment with the Company terminates
     pursuant to Section 4.1.4., (a) the Company shall pay to Executive as
     severance pay an amount equal to twelve times his then current base salary.
     payable in substantially equal monthly installments ("Severance Payments"),
     and distribute to him any sums accrued as of the termination date under the
     Company's retirement plan and other benefit plans (including accrued
     vacation pay, if any) and all other payments and benefits provided to
     Executive under this Agreement shall cease, (b) for a twelve month period
     after termination or such longer period as may be required by law.
     Executive shall be entitled to continue to receive medical benefits under
     the provisions of applicable laws (including COBRA) upon payment of the
     applicable premiums to the Company and (c) during the period in which the
     Executive is receiving Severance Payments, the Executive shall provide

                                      -3-
<PAGE>

     consulting services w the Company, as may be reasonably requested by the
     Company, subject to the Executive's reasonable availability.


                   ARTICLE 5. COVENANTS AGAINST COMPETITION

     5.1.  Non-solicitation of Employees.  Executive agrees that during the term
           -----------------------------
of Executive's employment with the Company and during the applicable Non-
competition Period (as defined below) after the termination of Executive's
employment with the Company, Executive shall not directly or indirectly recruit,
solicit or otherwise induce or attempt to induce any employees of the Company to
leave the employment of the Company.

     5.2.  Non-competition.  Executive agrees that during the term of
           ---------------
Executive's employment with the Company and during the applicable Non-
competition Period (as defined below) after the termination of Executive's
employment with the Company, Executive shall not directly or indirectly, except
as a passive investor in publicly held companies and except for investments held
at the date hereof, engage in competition with the Company or any of its
subsidiaries, or own or control any interest in or act as director, officer or
employee of, or consultant to, any firm, corporation or institution directly or
indirectly engaged in competition with the Company or any of its subsidiaries.

     5.3.  Non-competition Period.  In the event that Executive's employment is
           ----------------------
terminated pursuant to Section 4. 1. (other than pursuant to Section 4.1.1), the
Non-competition Period shall be twelve (12) months following the effective date
of Executive's termination without the payment of any compensation by the
Company to Executive beyond the Severance Payments provided in Section 4.2.3 in
the case of a termination pursuant to Section 4.1.4.

     5.4.  Academic Employment Permitted.  Notwithstanding the foregoing,
           -----------------------------
employment of Executive as a professor by a university of similar academic
institution shall not be deemed to be in competition with the business of the
Company.


                      ARTICLE 6. CONFIDENTIAL INFORMATION

     6.1.  Maintenance of Confidentiality.  Executive agrees that Executive will
           ------------------------------
not (except as required in the course of employment with the Company), both
during the term of Executive's employment with the Company and thereafter,
communicate or divulge to, or use for Executive's own benefit or the. benefit of
any other person, firm or organization, any confidential and proprietary
information of the Company and its subsidiaries.

     6.2.  Ownership of Confidential Information.  Records, riles, memoranda,
           -------------------------------------
reports, price lists, customer lists, drawings, plans, sketches and documents
and the like, relating to the business of the Company, which Executive shall use
or prepare or come into contact within the course of, in connection with, or as
a result of employment with the Company, shall remain the Company's Sole and
exclusive property.

                                      -4-
<PAGE>

                                  ARTICLE 7.
                            OWNERSHIP OF INVENTIONS

     7.1.  "Invention" Defined.  As used in this Agreement, "Invention" means
           -------------------
any invention, discovery or innovation with regard to physics, chemistry,
enzymology, biology, biotechnology, genetic engineering or recombinant DNA
technology, whether or not patentable, made, conceived, or first actually
reduced to practice by Executive, alone or jointly with others, in the course
of, in connection with, or as a result of service as an executive of the
Company, including any art, method, process, machine, manufacture, design of
composition of matter, or any improvement thereof, or any variety of plant or
microorganism.

     7.2.  Disclosure of Inventions.  Each Invention made, conceived or first
           ------------------------
actually reduced to practice by Executive, whether alone or jointly with others,
during the term Of Executive's employment with the Company and each Invention
made, conceived or first actually reduced to practice by Executive, whether
alone or jointly with others, within one year after the termination of
Executive's employment with the Company which relates in any way to work
performed for the Company during the term of Executive's employment, shall be
promptly disclosed in writing to the President of the Company (or such officer
of the Company as the President or Board of Directors may designate).  Such
report shall be sufficiently complete in technical detail and appropriately
illustrated by sketch or diagram to convey to one skilled in the art of which
the Invention pertains, a clear understanding of the nature, purpose,
operations, and, to the extent known, the physical, chemical, biological or
electrical characteristics of the Invention.

     7.3.  Ownership of Inventions.  Each Invention, as herein defined, shall be
           -----------------------
the sole and exclusive property of the Company.

     7.4.  Assignment of Title.  Executive agrees to execute an assignment to
           -------------------
the Company or its nominee of Executive's entire right, title and interest in
and to any Invention, without compensation beyond that provided in this
Agreement.  Executive further agrees, upon the request of the Company and at its
expense, that Executive will execute any other instrument and document necessary
or desirable in applying for and obtaining patents in the United States and in
any foreign country with respect to any Invention.  Executive further agrees,
whether or not Executive is than an employee of the Company, to cooperate to the
extent and in the manner reasonably requested by the Company in the prosecution
or defense of any claim involving a patent covering any Invention or any
litigation or other claim or proceeding involving any invention covered by this
Agreement, but all expenses thereof shall be paid by the Company.


                           ARTICLE 8. MISCELLANEOUS

     8.1.  Counterparts.  This Agreement may be executed in one or more
           ------------
counterparts, each of which shall be deemed an original, and all of which
together shall be deemed to be one and the same instrument.

                                      -5-
<PAGE>

     8.2.  Binding Effect.  This Agreement shall inure to the benefit of and be
           --------------
binding upon the parties hereto and their respective lawful successors and
assigns and upon Executive's heirs and personal representatives.

     8.3.  Assignment.  Neither this Agreement nor any rights or obligations
           ----------
hereunder shall be assignable by either party hereto without the prior written
consent of the other party.

     8.4.  Notices.  All notices, requests, demands and other communications to
           -------
be given pursuant to this Agreement shall be in writing and shall be deemed to
have been duly given if delivered by hand or mailed by registered or certified
mail, return receipt requested, postage prepaid or by facsimile transmission if
a true and correct copy is sent the same day by first class mail, postage
prepaid, or by dispatch by an internationally recognized express courier
service, and in each case addressed as follows:

     If to the Executive:   Dr. Hubert Koster
     -------------------
                            Stapelstr. 5b, 22529
                            Hamburg, Germany

     If to the Company:     Sequenom, Inc.
     -----------------
                            c/o Techno Venture Management
                            101 Arch Street
                            Suite 1950
                            Boston, Massachusetts 02110
                            Attn: President

     with a copy to:        Palmer & Dodge
                            One Beacon Street
                            Boston, Massachusetts 02108
                            Arm: Peter Wirth, Esq.

or such other address as either party hereto shall have designated by notice in
writing to the other party.

     8.5.  Amendments.  This Agreement may be amended, supplemented or otherwise
           ----------
modified at any time, but only by an instrument in writing signed by the parties
hereto.

     8.6.  Governing Law.  This Agreement and the legal relations among the
           -------------
parties hereto shall be governed by and construed in accordance with the laws of
the Commonwealth of Massachusetts.

     8.7.  Specific Performance.  The Executive acknowledges that money damages
           --------------------
alone will not adequately compensate the Company for breach of any of the
Executive's covenants and agreements herein and therefore, the Executive agrees
that in the event of the breach or threatened breach of any such covenant or
agreement, in addition to all other remedies available to the Company at law, in
equity or otherwise, the Company shall be entitled to injunctive relief
compelling specific performance of, or other compliance with, the terms hereof.

                                      -6-
<PAGE>

     8.8.  Severability.  In case any provision hereof shall, for any reason, be
           ------------
held to be invalid or unenforceable in any respect, such invalidity or
unenforceability shall not affect any other provision hereof, and this Agreement
shall be construed as if such invalid or unenforceable provision had wt been
included herein.  If any provision hereof shall for any reason, be held by a
court to be excessively broad as to duration, geographical scope, activity or
subject matter, it shall be construed by limiting and reducing it to make it
enforceable to the extent compatible with applicable law as then in effect.

     8.9.  Survival.  Articles 5, 6, 7 and 8 shall survive the termination of
           --------
this Agreement for the periods of time indicated therein or indefinitely if no
period of time is indicated.

     IN WITNESS WHEREOF, the undersigned have duly executed and delivered this
Agreement as of the date first above written.

                                        SEQUENOM, INC.



Date:  5-25-94                          By:  /s/ Nola E. Masterson
     ----------------------------            ----------------------------------
                                             Nola E. Masterson, President



                                        EXECUTIVE



Date:  May 26, 1994                      /s/ Hubert Koster
     ----------------------------       ---------------------------------------
                                        Hubert Koster

                                      -7-
<PAGE>

                         CONSULTING SERVICES AGREEMENT


     THIS AGREEMENT is entered into this 1st day of April, 1994, by and between
Sequenom, Inc. (the "Company") and Dr. Hubert Koster ("Consultant").

     NOW, THEREFORE, it is agreed as follows:

     1.   Definitions.  As used herein:
          -----------

          (a)  The term "Products" shall mean the devices, if any, proposed to
be developed by, or with the assistance of, Consultant hereunder as defined, and
with the specifications set forth in Exhibit A hereto.

          (b)  The term "Technology" shall mean the results and product (interim
and/or final) of the consulting services performed by Consultant hereunder,
whether tangible or intangibles including, without limitation, each and every
invention, formula, trade secret, software program (including without
limitation, object code, source code, flow charts, algorithms and related
documentation), listing, routine, manual, specification, technique, product,
concept, know-how, or similar property, whether or not patentable or
copyrightable and whether or not embodied in any Products, that are made,
developed, perfected, designed, conceived or first reduced to practice by
Consultant, either solely or jointly with others, in the course and scope of the
consulting services performed hereunder.

     2.   Engagement and Performance of Services.
          --------------------------------------

          (a)  Engagement.  The Company hereby engages Consultant to perform
               ----------
consulting services in accordance with the terms and conditions of this
Agreement. The specific tasks and services to be performed by Consultant are set
forth on Exhibit A attached hereto. If such services include the development of
specific Products, the specifications of such Products are as set forth on
Exhibit A attached hereto.

          (b)  Facilities, Equipment and Supplies.  The Company will provide to
               ----------------------------------
Consultant the facilities, equipment and supplies specified on Exhibit A
attached hereto. Consultant shall, at his own cost and expense, provide all
other facilities, equipment and supplies necessary to perform the consulting
services hereunder.

          (c)  Other Services. The Company acknowledges and agrees that, subject
               --------------
to its obligations hereunder, Consultant shall have the right to engage in
research and development and consulting activities for himself and others during
the term of this Agreement; provided, however, that Consultant shall not perform
any consulting services for an actual or potential competitor of the Company
during the term of this Agreement and for a period of one (1) year after
termination of this Agreement.
<PAGE>

          (d)  Primary Duty.  The Company and Consultant recognize that
               ------------
Consultant's Primary duty as a member of the faculty of the University of
Hamburg (the "University") is to the University.  The Company and consultant
agree that the University's policies and Consultant's obligations to the
University shall be observed in the event a conflict arises with this Agreement.

          (e)  Compensation.  As compensation for the consulting services
               ------------
provided by Consultant hereunder, the Company shall pay to Consultant the
amounts specified, at the time(s) specified, on Exhibit B attached hereto.

          (f)  Expenses. In addition to the compensation specified in subsection
               --------
2(d), the Company will pay reasonable out-of-pocket expenses incurred by
Consultant and approved in advance by the Company in the furtherance of or in
connection with the performance of consulting services hereunder.

          (g)  No Violation of Others' Rights.  Consultant represents and
               ------------------------------
warrants that in the course of performing services hereunder Consultant will not
infringe or wrongfully appropriate any patents, copyrights, trade secret rights,
or other intellectual property rights of any person or entity anywhere in the
world.

     3.   Employment Agreement.  On or before the date hereof, the Company and
          --------------------
the Consultant shall have entered into an Executive Employment Agreement (the
"Employment Agreement").  The provisions of this Agreement shall not supersede
the provisions of the Employment Agreement, and the Consultant specifically
acknowledges that the provisions of Articles 5, 6 and 7 of the Employment
Agreement shall apply during the period of his consultancy hereunder.

     4.   Property Rights.  All right, title and interest in and to the Products
          ---------------
(if any) and the Technology shall at all times be and remain the sole and
exclusive property of the Company, and the Products and the Technology shall be
deemed to be works made for hire. The parties agree that any patents, trademarks
or copyrights that may issue relating to any of the Products or the Technology
shall be in the name of and assigned to the Company.

     5.   Term and Termination. The term of this Agreement shall be as set forth
          --------------------
in Exhibit A attached hereto; provided, however, that this Agreement shall
automatically terminate upon the commencement of Consultant's services under the
Employment Agreement.  Unless otherwise specified in Exhibit A, either party may
terminate this Agreement at any time upon thirty (30) days written notice
delivered to the other.  The provisions of Sections 3 and 4 hereof shall survive
the termination of this Agreement.

     6.   Miscellaneous.
          -------------

          (a)  Use of University's Name.  With the limited exception of citing
               ------------------------
Consultant's faculty title, the Company and its affiliates will not use the
names, likeness, or logos of the University or any of its schools or divisions
in any of their fund raising or in investment documents, general publications,
advertisements, or marketing and promotional materials without the prior written
permission of the University.  A request for such permission must be submitted
by Consultant to the University's Office of Public Affairs.

                                      -2-
<PAGE>

          (b)  Relationship of Parties. Consultant shall at all times during the
               -----------------------
performance of his services hereunder be an independent contractor, maintaining
sole and exclusive control over its business and operations. At no time will
either party hold itself out to be the agent, employee, lessee, sublessee,
partner or joint venturer of the other party. Neither party hereto shall have
the express or implied right or authority to assume or create any obligation on
behalf of or in the name of the other party, or to bind the other party in
regard to any contract, agreement or undertaking with any third party.

          (c)  Entire Agreement.  Except as set forth in Section 3, this
               ----------------
Agreement, together with the exhibits attached hereto, constitutes the entire
agreement between the parties relating to the subject matter hereof and
supersedes all prior written or oral negotiations, representations or
agreements.  No modification of this Agreement shall be binding on either parry
unless it is in writing and signed by both parties.

          (d)  Severability. The provisions of this Agreement are severable, and
               ------------
if one or more provisions are judicially determined to be illegal or otherwise
unenforceable, in whole or in part, the remaining provisions or portions of this
Agreement shall nevertheless be binding on and enforceable by and between the
parties hereto.

          (e)  Assignment.  This Agreement shall inure to the benefit of and be
               ----------
binding upon the successors and assigns of the parties hereto; provided,
however, that Consultant shall not transfer or assign this Agreement without the
prior written consent of the Company.

          (f)  Governing Law.  The rights and obligations of the parties to this
               -------------
Agreement shall be governed by and construed in accordance with the laws of
Massachusetts.

          (g)  Headings.  Section headings are for convenience of reference only
               --------
and shall not be considered in the interpretation of this Agreement.

          (h)  Unavoidable Delays.  Either party shall be excused for any delays
               ------------------
or defaults in the performance of this Agreement (except the payment of amounts
due and payable hereunder) unavoidably caused by the act of the other, the act
of any agent of the other, the act of any governmental authority, acts of God,
the elements, war, litigation, strikes, walkouts, or any other cause beyond its
reasonable control. Each party shall use all reasonable diligence to avoid any
such delay or default and to resume performance under this Agreement as soon as
practicable after such delay or default.

          (i)  Notices.  All notices, requests, demands and other communications
               -------
to be given pursuant to this Agreement shall be in writing and shall be deemed
to have been duly given if delivered by hand or mailed by registered or
certified mail, return receipt requested, postage prepaid or by facsimile
transmission if a true and correct copy is sent the same day by first class
mail, postage prepaid, or by dispatch by an internationally recognized express
courier service, and in each cm addressed as follows:

                                      -3-
<PAGE>

     If to the Consultant:   Dr. Hubert Koster
     --------------------
                             Stapelstr. 5b, 22529
                             Hamburg, Germany

     If to the Company:      Sequenom, Inc.
     -----------------
                             c/o Techno Venture Management
                             101 Arch Street
                             Suite 1950
                             Boston, Massachusetts 02110
                             Attn:  President

     with a copy to:         Palmer & Dodge
                             One Beacon Street
                             Boston, Massachusetts 02108
                             Attn:  Peter Wirth, Esq.

or such other address as either party hereto shall have designated by notice in
writing to the other party.

          (j)  Attorneys' Fees and Costs. Should litigation arise concerning the
               -------------------------
enforcement or interpretation of this Agreement, the prevailing party shall be
entitled to recover its reasonable attorneys' fees and costs as determined by
the court.

     IN WITNESS WHEREOF, the Parties hereto have executed this Agreement on the
date first above written.


SEQUENOM, INC.                                CONSULTANT:


By: /s/ Nola E. Masterson                     /s/ Hubert Koster
   ---------------------------------          ----------------------------------
                                              Dr. Hubert Koster
Title:  CEO
      ------------------------------

                                      -4-
<PAGE>

                                   EXHIBIT A
                                   ---------

                       DESCRIPTION OF SERVICES AND TASKS

                                [see attached]

                                      -5-
<PAGE>

                                                                       EXHIBIT A

          1.   SEQUENOM H. KOSTER MARCH 31, 1994 CONFIDENTIAL



                                R & D PROJECTS
                         TO BE PERFORMED BY CONSULTANT


There are six Mini-Teams (T1 - T5) with selected experience; several projects
therefor can be initiated and pursued in parallel.

                                      ***

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

          2.   SEQUENOM H. KOSTER MARCH 31, 1994 CONFIDENTIAL

                                      ***

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

          3.   SEQUENOM H. KOSTER MARCH 31, 1994 CONFIDENTIAL

                                      ***

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

          4.   SEQUENOM H. KOSTER MARCH 31, 1994 CONFIDENTIAL

                                      ***

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                   EXHIBIT B
                                   ---------

                       COMPENSATION AND PAYMENT SCHEDULE


In return, Sequenom will provide to the consultant:

(1)  full compensation for round-trip airfare, hotel accommodations, meals and
     other expenses related to consultant's regular visits to Sequenom or
     attendance at Scientific Advisory Board meetings;

(2)  full compensation for round-trip airfare, hotel accommodations, meals and
     other expenses related to consultant's travel to scientific meetings for
     which his attendance is deemed critical to the development of mass
     spectrometric DNA-sequencing technologies, or for visits to companies,
     patent offices or for any other travel carried out in connection with his
     work with Sequenom; and

(3)  full compensation for other expenses (fax, mail, etc.) encountered directly
     in connection with his work for Sequenom.

(4)  commencing as of April 1, 1994, a monthly consultancy fee of $5,000, to be
     paid monthly in arrears with the first payment of $5,000 due on May 1, 1994
     and covering the period from April 1, 1994 to April 30, 1994.

                                      -6-
<PAGE>

                                 EXHIBIT 4.13
                                 ------------

                              Material Agreements
                              -------------------

(a)  None.

(b)  None.

(c)  (1)  See Exhibit 4.8 with respect to agreements with Dr. Koster.
              -----------

     (2)  Consulting services Agreement between the Corporation and Charles
          Cantor dated April 1, 1994.

     (3)  consulting Services Agreement between the Corporation and Robert
          Cotter dated April 1, 1994, as amended.

     (4)  Oral consulting agreement with Nola Masterson, pursuant to which Ms.
          Masterson is paid $5,000 per month to assist the corporation in
          developing business strategies and monitoring U.S. operations.

(d)  (1)  Sequenom, Inc. 1994 Stock Plan.

     (2)  The Corporation also provides medical and dental benefits to its
          employees.

(e)  The Corporation has borrowed an aggregate of $1,580,000 in outstanding
     principal amount from certain of the Investors and has issued to such
     Investors convertible term notes to evidence a portion of such loans.  None
     of such loans will remain outstanding after the Initial Closing.  The
     corporation has also borrowed DM 550,000 in outstanding aggregate principal
     amount from its wholly owned subsidiary Sequenom Instruments GmbH.

(f)  None.

(g)  Equipment lease arrangements with COMDISCO.

(h)  None.

(i)  (1)  Research Agreement between the Corporation and The Johns Hopkins
          University, dated October l, 1994, an amended.

     (2)  Confidentiality/Materials Transfer Agreement between the Corporation
          and Becton Dickinson and Company dated December 1, 1995.

     (3)  Sponsored Research Agreement between the Corporation and the Trustees
          of Boston University dated September 15, 1994.

     (4)  Proposed Letter Agreement with Synteni.

(j)  None.

(k)  None.
<PAGE>

                                 EXHIBIT 4.15
                                 ------------

                                   Insurance
                                   ---------

     See attached materials from Waverley Insurance Agency, Inc. with respect to
insurance maintained by the Corporation.
<PAGE>

Professional
Office
Package



                        WAVERLEY INSURANCE AGENCY, INC.

                               493 Trapolo Road
                               Belmont, MA 02173
<PAGE>

CONTENTS
- --------

We've designed your Professional Office Package so it can be tailored to fit
your individual insurance needs.  Because each policy may be different, the
pages aren't numbered consecutively.  Here's a list of commonly referred to
items in the same order as they appear in your policy.

Introduction Page

Name and mailing address of insured
Name and location of insurance company
Policy dates
Former policy number
Your premium
Name and address of our authorized representative

Policy Forms List

General Rules

Special rights and duties of the first named insured
Your policy period
Premiums
Our right to inspect and audit
Policy changes
Assignment and transfer
Cancellation
Recovering damages from a third party
Fraud and misrepresentation
Appraisal of property disputes
How state law affects this policy
Lawsuits against us
Provisions required by law

What To Do If You Have A Loss

Coverage Summary

The Coverage Summary shows the variable information that affects your coverage.

Coverages

Each type of coverage included in your policy is provided by a separate form
called an insuring agreement.
<PAGE>

POLICY INFORMATION

THIS IS NOT A BILL

YOUR POLICY IS DIRECTLY BILLED. IF THIS IS A POLICY CHANGE, THE
ADDITIONAL OR RETURN PREMIUM WILL BE SHOWN ON FUTURE INSTALLMENT
BILLINGS. IF ALL INSTALLMENTS HAVE BEEN BILLED, THE PREMIUM
CHANGE WILL BE BILLED OR CREDITED PROMPTLY.
A BILL WILL BE SENT TO:
THE INSURED

- --------------------------------------------------------------------------------
Company:  ST. PAUL FIRE & MARINE INSURANCE COMPANY

- --------------------------------------------------------------------------------
I                                   Policy Inception/Effective Date:  10/26/94
N                                   Policy Number:  FK06003565
S                                   Agency Number:  2003083
U   SEQUENOM INCORPORATED
R   _________________               Transaction Type:
E   101 ARCH STREET                 POLICY IS NEW
D   BOSTON, MA 02110                Transaction number:  001
                                    Processing Date:  11/10/94 08:57
  __________________________________
A   WAVERLY INS AG INC
G   493 TRAPELO RD
E   BELMONT MA 02178
N
T

- ------------------------------------------------------------------------------
Policy           Description                 Amount                 Surtax/
Number                                       Surcharge
- ------------------------------------------------------------------------------

FK 06003565 PROFESSIONAL OFFICE PACKAGE POLICY        $350.00

THE PREMIUM SHOWN DOES NOT INCLUDE A PREMIUM PAYMENT PLAN SERVICE CHARGE.  IF
YOU SELECTED A PREMIUM PAYMENT PLAN YOUR PAYMENT SCHEDULE/BILL WILL SHOW THIS
CHARGE.

THIS POLICY IS A NINE PAY PAYMENT PLAN.
A PAYMENT SCHEDULE/BILL WILL FOLLOW SHORTLY.


- --------------------------------------------------------------------------------
Ed. 12 - 90 Printed in U.S.A.                                             Page 1

                                 INSURED COPY
<PAGE>

                                                                    THE ST. PAUL


POLICY FORM LIST

Here's a lit of all forms included in your
policy [ILLEGIBLE] the date shown below.  These forms
are [ILLEGIBLE] in the dame order as they appear in
your policy.

<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------------------
Title                                                                      Form Number      Edition Date
<S>                                                                        <C>              <C>
Introduction - St. Paul Fire and Marine Insurance Company                      40800            05-87
     Policy Form List                                                          40705            05-84
General Rules - Massachusetts                                                  40731            05-92
What to do if you have a loss                                                  40814            11-91
Professional Office Package Coverage Summary                                   46157            05-91
Professional Office Package Location Coverage Summary                          46159            05-91
Professional Office Package Property Protection                                46156            09-91
POP - Commercial General Liability Protection                                  46155            05-91
   Medical Expenses Endorsement                                                46190            09-93
   Auto Contract Liability Endorsement-Massachusetts                           44412            01-89
   Contract Liability Defense Expenses Endorsement                             47320            03-92
Liability Protection For Autos You Don't Own                                   44471            04-91


- -----------------------------------------------------------------------------------------------------------
Name of Insured           Policy Number  FK06003565                  Effective Date 10/26/94
SEQUENUM INCORPORATED         Processing Date  11/10/94              08:57  001
- -----------------------------------------------------------------------------------------------------------
</TABLE>

4070 5-84 Printed in U.S.A.                     Form List                Page 1
(C)St. Paul Fire and Marine Insurance Co. 1992
<PAGE>

                                                                    THE ST. PAUL

<TABLE>
<S>                                                          <C>
 discovery of fraud or material misrepresentation by the     company a signed, sworn statement in proof of loss which
 insured in obtaining the policy; (4) discovery of willful   sets forth to the best knowledge and belief of the insured
 or reckless acts or omissions by the insured increasing     the following: the time and cause of the loss, the interest
 the hazard insured against; (5) physical changes in the     of the insured and of all others in the property, the actual
 property insured which result in the property becoming      cash value of each item thereof and the amount of loss
 uninsurable; or (6) a determination by the commissioner     thereto, all encumbrances thereon, all other contracts of
 that continuation of the policy would violate or place      insurance, whether valid or not, covering of said property,
 the insurer in violation of the law.  Where the stated      any changes in the title, use, occupancy, location,
 reason is [ILLEGIBLE] of premium, the insured may           possession or exposures of said property, since the issuing
 [ILLEGIBLE] coverage and avoid the effect of the            of this policy, by whom and for what purpose any building
 cancellation by payment at any time prior to the            herein described and the several parts thereof were occupied
 effective date of cancellation.                             at the time of loss and whether or not it then stood on
                                                             leased ground, and shall furnish a copy of all the
 Mortgage interests and obligations.  Notwithstanding any    descriptions and schedules in all policies and detailed
 other provisions of this policy, if the policy shall be     estimates for repair of the damage.  The insured, as often
 made payable to a mortgage of the covered real estate, no   as may be reasonably required, shall exhibit to any person
 act or default of any person other than such mortgagee or   designated by this company all that remains of any property
 his agent or those claiming under him, whether the same     herein described, and submit to examinations under oath by
 occurs before or during the term of this policy, shall      any person named in this company, and subscribe the same;
 render this policy void as to such mortgagee nor affect     and, as often as may be reasonably required, shall produce
 such mortgagee's right to recover in case of loss of such   for examination all books of account, bills, invoices and
 real estate: provided, that the mortgagee shall on demand   other vouchers, or certified copies thereof if originals be
 [ILLEGIBLE] according to the established scale of rate      lost, at such reasonable time and place as may be designated
 for any increase of risk not paid for by the insured; and   by this company or its representative, and shall permit
 whenever this company shall be liable to a mortgagee for    extracts and copies thereof to be made.
 any sum for loss under this policy for which no liability
 exists as to the mortgage, or owner, and this company       When loss payable.  In case of any loss or damage, the
 shall elect by itself, or with others, to pay the           company, within thirty days after the insured shall have
 mortgagee the full amount secured by such mortgagee, then   submitted a statement, as provided in the preceding clause,
 the mortgagee shall assign and transfer the company         shall either pay the amount for which it shall be liable,
 interested, upon such payment, the said mortgage together   which amount if not agreed upon, shall be ascertained by
 with the [ILLEGIBLE] debt thereby secured.                  award of referees as hereinafter provided or replace the
                                                             property with other of the same kind and goodness; or it
 Pro rata liability.  This company shall not be liable for   may, within fifteen days after such statement is submitted,
 a greater proportion of any loss than the amount hereby     notifying insured of its intention to rebuild or repair the
 insured shall bear to the whole insurance covering the      premises, or any portion thereof separately covered by this
 property against the [ILLEGIBLE] involved.                  policy, and shall thereupon enter upon said premises and
                                                             proceed to rebuild or repair the same with reasonable
 [ILLEGIBLE] in case loss occurs.  The insured shall give    expedition.  It is moreover understood that there can be no
 immediate written notice to this company of any loss,       abandonment of the property described to the company and
 protect the property from further damage, forthwith         that the company shall not in any case be liable for more
 separate the damaged and undamaged personal property, put   than the sum insured, with interest thereon from the time
 in the best possible order, furnish a complete inventory    when the loss shall become payable, as above provided.  The
 of the destroyed and damaged property, showing in detail    company shall be liable for the payment of the interest to
 the quantity, description, actual cash value and amount     the
 of loss claimed; and the insured shall forthwith render
 to this

- -------------------------------------------------------------------------------------------------------------------------------
</TABLE>

[ILLEGIBLE] Rev. 5-92 Printed in U.S.A.         General Rules
(C)St. Paul Fire and Marine Insurance Co. 1992 All Rights Reserved   Page 3 of 7
<PAGE>

                                                                    THE ST. PAUL

<TABLE>
<S>                                                     <C>
Calculation of premium.  We'll figure your premium      of these examinations.  We'll reduce the amount we pay
due on each anniversary in accordance with our rule,    on the medical expense claim by whatever we pay for
rates and rating plans in effect on the anniversary     these services.  The fact that we make payments to any
date.                                                   injured person for these services doesn't mean you've
                                                        admitted responsibility for his or her injury.
The following paragraph replaces any Protective
Safeguards section in your policy.                      Property Protection - Buildings That Are Vacant

Protective safeguards.  You must also maintain any      If your policy includes Property Protection, the
protective safeguards that are described in the         following is added to the "Buildings that are vacant"
Protective Safeguards Endorsement.  We [ILLEGIBLE]      section of your agreement.  But only for loss caused by
credit for these protective safeguards in setting       fire or lightning.
our rates.  If you fail to maintain these
safeguards, we won't be liable for losses to the        If your building where a loss occurred was vacant or
specifically affected areas.  However, your             unoccupied for a period of:
[ILLEGIBLE] will continue for other areas.
                                                        .  50 consecutive days for the residential properties
The following paragraph replaces any "Medical Reports   of 3 units or less; or
and Examinations" section in your policy.

Medical reports and examinations.  The insured person   .  30 consecutive days for all other premises;
must give us written proof of his [ILLEGIBLE] claim
for medical expenses as soon as possible, and must      before the loss occurred, we won't pay for the loss.
agree to make the claim under oath if we think it is    This applies regardless of whether or not the building
necessary.  We must also receive an authorization       had been intended for occupancy by either the owner or
allowing us to obtain pertinent medical reports and     tenant.
copies of records.  The injured person must agree to
be examined by doctors of our choosing as often as      The following is added to the If Your Building is
we decide, within reason.  We'll pay the cost           Mortgaged section.  We'll make payments for losses to
                                                        mortgage holders in order, according to the financial
                                                        interest each has in the covered property.

- ----------------------------------------------------------------------------------------------------------------------
</TABLE>

[ILLEGIBLE] Rev. 5-92 Printed in U.S.A.              General Rules
(C)St. Paul Fire and Marine Insurance Co. 1992 All Rights Reserved   Page 7 of 7
<PAGE>

                                                                    THE ST. PAUL

     PROFESSIONAL OFFICE PACKAGE COVERAGE SUMMARY

This summary shows the Limits of Coverage
and the Optional Coverages you have for state
or [ILLEGIBLE] coverages. These coverages
and [ILLEGIBLE] apply to all locations on your policy.
[ILLEGIBLE] your Professional Office Package
[ILLEGIBLE] Coverage Summary for coverages that
[ILLEGIBLE] a specific location.

<TABLE>
<CAPTION>
- -------------------------------------------------------------------------------------------------
Commercial General Liability Protection        Limits of Coverage
<S>                                            <C>                                 <C>
                                               Each event limit                    $1,000,000
                                               Premises damage limit.              $1,000,000
                                               Medical expenses limit.             $    5,000

                                               Personal injury and                 $1,000,000
                                               advertising injury limit

                                               General total limit.                $2,000,000
- -------------------------------------------------------------------------------------------------
Loss of Earnings And Extra
 Expense Coverage                              Limit of coverage                      $  500,000
- -------------------------------------------------------------------------------------------------
Optional Coverages                                                           Premium
Liability Protection For Autos You Don't Own
        Limit: $1,000,000
        Non-owned Auto              Number of Employees: 2                            $    18.00
        Hired Auto                  If Any                                            $    29.00



- -------------------------------------------------------------------------------------------------
Year Premium for the above
 coverages                                                                            $    47.00
- -------------------------------------------------------------------------------------------------
Name of Insured                   Policy Number  FK06003565                  Effective Date 10/26/94
SEQUENOM INCORPORATED             Processing Date   11/10/94     08:57   001
</TABLE>

- --------------------------------------------------------------------------------
[ILLEGIBLE] Ed. 5-91 Printed in U.S.A.            Coverage Summary        Page 1
(C)St. Paul Fire and Marine Insurance Co. 1992 All Rights Reserved
- --------------------------------------------------------------------------------
<PAGE>

                                                                    THE ST. PAUL

<TABLE>
<S>                                                          <C>
Power supply services means:                                 we'll only pay for such increase during the period of
 .  [ILLEGIBLE] generating plants;                            restoration.
 .  switching stations;
 .  substations;                                               Strike.  We won't cover any increase in loss due to
 .  transformers; and                                          delay caused by strikers or anyone else at a location
 .  transmission lines;                                        of rebuilding, repairing or replacing damaged property
supplying electricity, steam, or gas to the described         when it interferes with efforts to resume business.
premises.
                                                              However, you can recover for an increase in a covered
But coverage isn't included for overhead transmission         loss when a strike on another person's premises
lines unless indicated in the Coverage Summary.               prevents you from resuming business.  For example:

Off premises utility failure limit of coverage.  The          You've ordered materials to repair your building and
most we'll pay for your earnings and extra expense            you can't obtain them because there's a strike at the
loss in any one event is $25,000 unless the                   manufacturer's plant.  This prevents you from resuming
additional optional coverage for off-premises utility         business and increases your loss of earnings and extra
failure is indicated in the Coverage Summary.  If the         expense.  We'll cover this increase in your loss.
option is shown, your loss of earnings and extra
expense limit shown on the Coverage Summary includes          Expenses for putting out a fire.  We won't cover
the $25,000 automatic coverage.  This is the most             expenses you have in putting out a fire.
we'll pay for all covered loss caused by any one
event.                                                        Direct Loss.  We won't cover any direct damage to
                                                              property.
Loss of earnings and extra expense exclusions.  All of
the exclusions under the Exclusions - Losses We Won't         Rules for loss of earnings and extra expense loss
Cover section apply to this coverage.  The following          adjustment.  When covered earnings or extra expense
exclusions also apply to Loss Of Earnings And Extra           loss occurs, we'll consider the following in
Expense Coverage.                                             determining what we'll pay under this coverage:

Repair.  We won't cover the cost of repairing or              1.  loss determination
replacing damaged property, including the cost of             2.  your responsibility for resuming operations; and
research necessary to replace or restore [ILLEGIBLE]          limit of coverage.
account books, card index systems, data processing,
recording or storage media and other records.  But we         1.  Loss determination.
will pay any expense you incur over the normal cost           1.  Earnings.  Your amount of earnings loss will be
of such repair or replacement if it's necessary to            determined based on:
reduce your total extra expenses due to a covered             .  net income of your business before the direct
loss.                                                         physical loss or damage occurred;
                                                              .  the probable net income if no loss or damage had
This extra expense for repair or replacement may not          occurred;
be more than the amount by which it reduces your              .  the operating expenses, including payroll, expenses,
total extra expense loss.                                     necessary to resume operations with the same quality of

Cancellation of Contracts.  We won't cover any                service that existed just before the direct physical
[ILLEGIBLE] in loss that's caused by the suspension,          loss or damage; and
lapse or cancellation of any lease, license, contract         .  other sources of information on your business such
or order.                                                     as: your financial records and accounting procedures,
                                                              bills, invoices and other vouchers and deeds, liens or
However, if the suspension, lapse or cancellation             contracts.
results directly from the interruption of your
business, we'll cover any increase in a [ILLEGIBLE]           2.  Extra expense.
that affects your earnings.  But
</TABLE>

- --------------------------------------------------------------------------------
46156 Rev.9-91 Printed in U.S.A.     Insuring Agreement 5           Page 5 of 22
(C)St. Paul Fire and Marine          Property Coverage
Insurance Co. 1991
<PAGE>

                                                                    THE ST. PAUL

PROFESSIONAL OFFICE PACKAGE
PROPERTY PROTECTION

We have designed this agreement to protect you
and your business against a variety of direct
and indirect losses.  Of course, there are [ILLEGIBLE]
which are explained later in this agreement.

<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------------------------
Table of Contents                           Page    What This Agreement Covers
                                                    --------------------------
<S>                                         <C>     <C>
What This Agreement Covers                   1      The description of covered property and limit of coverage
[ILLEGIBLE] Coverage                         1      are shown in the Coverage Summary.  In this section, we
Business Contents Coverage                   2      explain what is included under the building and business
Preservation Of Property                     2      contents coverage.
Debris Removal Coverage                      2      Building Coverage
Loss Of Earnings And Extra Expense
[ILLEGIBLE]                                  3      We'll cover your financial interest in the insured building
Property That Has Limited Coverage           6      or structure.  While at the same location we'll also cover:
Property Covered Only As Defined             6      .  garages, storage buildings and other structures that
Property Not Covered At All                  7      pertain to your office.
                                                    .  fixtures, machinery and equipment that are a permanent
Additional Benefits                          7      part of the building and are used to provide building
[ILLEGIBLE] Clean Up And Removal             7      services such as elevators and hearing equipment.
Temporary Location Or Property In Transit    7      .  yard fixtures such as lamp posts and flag poles.
Fire Department Service Charge               8      .  construction materials, supplies and equipment that you
Newly Acquired Property                      8      intend to use to alter, repair or expand the covered
Loss Assessments                             8      building.  During construction we'll cover these materials
[ILLEGIBLE] Property                         8      at the insured location or in the open within 1,000 feet of
Personal Belongings                          8      it.  We'll also cover any temporary structures at the
Accounts Receivable Coverage                 9      insured location.
Valuable Records Research Coverage           9      .  property which you own and use to service or maintain the
[ILLEGIBLE] And Securities Coverage         10      covered building or structure or its premises such as
Covered Causes Of Loss                      11      outdoor furniture, fire extinguishing equipment, floor
                                            11      coverings and appliances for refrigerating, ventilating,
Exclusions - Losses We Won't Cover                  cooking, dishwashing and laundering.
                                            15      .  personal property you own in rooms or apartments you
Optional Coverages                          15      furnish as landlord.
Optional Glass Coverage                     16
Optional Sign Coverage                      16      Building inflation protection.  At the end of each 3 months
Optional Scheduled Valuables Coverage       17      this agreement is in effect, we'll increase your insurance
Optional Computer Coverage                  18      by the percentage shown in the Coverage Summary.  This
Rules For Loss Adjustment                   18      percentage applies only to the building limit shown
1. How Your Property Is Valued              20      [ILLEGIBLE] the Coverage Summary and not to the increases
2. Deductible                               20      you're given under this building inflation protection.  For
3. [ILLEGIBLE] Insurance                    20      example:
[ILLEGIBLE] Losses                          21
Who will [ILLEGIBLE] For Loss               21
If [ILLEGIBLE] Is Mortgaged
                                            21
Other Rules For This Agreement
- --------------------------------------------------
</TABLE>

- --------------------------------------------------------------------------------
46156 Rev.9-91 Printed in U.S.A.     Insuring Agreement 5          Page 1 of 22
(C) St. Paul Fire and Marine         Property Coverage
Insurance Co. 1991
<PAGE>

                                                                    THE ST. PAUL

<TABLE>
<S>                                                      <C>
Accounts Receivable Coverage                             Accounts Receivable Coverage exclusions.
                                                         Bookkeeping errors.  We won't cover any loss that's
If you have Business Contents Coverage, we'll protect    caused by mistakes or omissions in bookkeeping,
your accounts receivable records against risks of        accounting or billings.
direct loss or damage.

We automatically cover your accounts receivable up to    In addition, the following exclusions under the
$5,000 unless an accounts receivable limit of            Exclusions - Losses We Won't Cover section also apply
coverage is shown in the Coverage Summary.  If an        to this coverage:
accounts receivable [ILLEGIBLE], the $5,000 automatic    .  Government action;
coverage will be included and is not in addition to      .  Illegal transportation or trade;
such limit.                                              .  Nuclear transportation or trade;
                                                         .  Nuclear activity;
The [ILLEGIBLE] we'll pay for all covered accounts       .  War;
[ILLEGIBLE] loss in any one event is $5,000 or the       .  Electronic recordings;
accounts receivable limit shown in the coverage          .  Dishonesty;
summary, whichever is [ILLEGIBLE].                       .  Voluntary surrender;
                                                         .  Acts or decisions of people;
We cover the following costs that you incur when your    .  Planning, design, materials, maintenance; and
records of accounts receivable are damaged or loss       .  Disappearance-inventory loss.
because of a covered cause of loss.
 .  [ILLEGIBLE] your customers owe you but you can't      No other exclusions under the Exclusions - Losses We
collect because of loss or damage to your [ILLEGIBLE];   Won't Cover section apply to this coverage.
 .  [ILLEGIBLE] only on any loan you have to take out
because you can't collect your receivables, and need     Valuable Records Research Coverage
money while waiting for your claim to be paid;
 .  [ILLEGIBLE] collection costs, over and above your     If you have Business Contents Coverage, we'll protect
[ILLEGIBLE] collection costs, that are made necessary    your valuable records against risks of direct physical
because of their loss or damage to your [ILLEGIBLE]      loss or damage.  We'll also protect anyone else's
and                                                      valuable records that are in your care.  If research is
 .  [ILLEGIBLE] you reasonably incur in re-establishing   necessary to replace the item, we'll pay for the
your records.                                            expense involved.  For example, if maps are lost or
                                                         damaged we'll pay for the surveying and photographing
We also cover your accounts receivable [ILLEGIBLE]       necessary to replace them.
while they're away from an insured [ILLEGIBLE] at a
safe place because of imminent [ILLEGIBLE] of loss.      We'll automatically cover your valuable records loss up
And we'll cover those records [ILLEGIBLE] they're        to $10,000 unless a valuable records limit of coverage
being moved to and from that safe [ILLEGIBLE].  But      is shown in the Coverage Summary.  If a valuable
you must tell us within 10 days after you receive the    records limit is shown, the $10,000 automatic coverage
records for this coverage to [ILLEGIBLE].                will be included [ILLEGIBLE] not in addition to such
                                                         limit.
[ILLEGIBLE] covered.  You're covered for losses
[ILLEGIBLE] at the location shown in the Coverage        The most we'll pay for all covered valuable records
Summary, at a storage location or while temporarily      loss in any one event is $10,000 or the valuable
within the premises of others.  Your accounts            records limit shown in the Coverage Summary, whichever
receivable records are also covered [ILLEGIBLE]          is more.
transit within the United States of America, Puerto
Rico or Canada.                                          Valuable records includes account books, manuscripts,
                                                         abstracts, drawings, card index systems and other
                                                         printed or written documents.  Valuable records also
                                                         include maps, films, tapes and other such material.
                                                         But it doesn't include electronic data processing
                                                         media, data or programs.
</TABLE>

- --------------------------------------------------------------------------------
46156 Rev.9-91 Printed in U.S.A.  Insuring Agreement 5              Page 9 of 22
(C)St. Paul Fire and Marine Insurance Co. 1991  Property Coverage
<PAGE>

                                                                    THE ST. PAUL

<TABLE>
<S>                                                           <C>
[ILLEGIBLE] we'll pay for the damage caused by the fire.      Planning, design, materials, maintenance.  We won't cover
                                                              loss caused by faulty, inadequate or defective:
Electronic recordings.
                                                              .  planning, zoning, development, surveying, siting;
We won't cover loss to electronic recordings caused by        .  design, specifications, workmanship, repair,
electrical or [ILLEGIBLE] injury, disturbance or erasing.     construction, renovation, remodeling, grading, compaction;
This [ILLEGIBLE] doesn't apply to loss caused by lightning.   .  materials used in repair, construction, renovation or
[ILLEGIBLE] action.  We won't cover loss caused [ILLEGIBLE]   remodeling; or
indirectly by any of the following.  [ILLEGIBLE] is           .  maintenance.
excluded regardless of any other [ILLEGIBLE] event that
contributes concurrently or [ILLEGIBLE] sequence to the       All of the above apply to part or all of any property on or
loss:                                                         off the location described in the Coverage Summary.

Mechanical Breakdown.                                         But if a loss not otherwise excluded results, we'll pay for
                                                              that resulting loss.
We won't cover loss to [ILLEGIBLE] property caused or made
worse by                                                      Pollution.  We won't pay for loss that results from
                                                              pollution unless the pollution is caused by any of the
 .  [ILLEGIBLE] caused by centrifugal force; or                following causes of loss:
 .  [ILLEGIBLE] due to faulty work, design, materials or
[ILLEGIBLE].                                                  .  fire;
                                                              .  lightning;
But [ILLEGIBLE] not otherwise excluded results [ILLEGIBLE]    .  explosion;
of these causes, we'll pay for the loss that results          .  wind or hail;
directly from the covered cause.                              .  smoke;
                                                              .  vehicles and aircraft;
Nuclear activity.  We won't cover loss caused directly or     .  civil disturbance and riot;
indirectly by nuclear reaction, nuclear radiation, or         .  vandalism;
radioactive contamination.  Such loss is excluded             .  sprinkler leakage;
regardless of any other cause or event that contributes       .  sinkhole collapse;
concurrently or in [ILLEGIBLE] to the loss.  But if loss      .  volcanic action;
or damage by fire results, we'll pay for that resulting       .  falling objects;
loss or damage, if it would otherwise be covered under        .  weight of snow, ice or sleet; or
this agreement.                                               .  water damage.

Ordinances, regulations or laws.  We won't cover loss         Pollution means the actual, alleged or threatened discharge,
caused directly or indirectly by the [ILLEGIBLE] of any       dispersal, release leakage, seepage, migration or escape of
ordinance, regulation [ILLEGIBLE] the use, construction,      pollutants.
repair [ILLEGIBLE] of any property.
This includes removal of debris.  Such loss is [ILLEGIBLE]    However, we won't pay for the costs associated with the
regardless of any other cause or event that contributes       enforcement of any ordinance, regulation or law which
concurrently or in any sequence to the [ILLEGIBLE].  But      requires you or anyone else to:
this exclusion won't apply to property destroyed by a
civil authority in order to [ILLEGIBLE] the actual spread     .  test for, monitor, clean up, remove;
of fire.  For example, to establish a fire break.             .  contain, treat, detoxify or neutralize; or
                                                              .  in any way respond to, or [ILLEGIBLE] the effects of
                                                              pollutants.
                                                              Pollutants means any solid, liquid, gaseous or thermal
                                                              irritant or contaminant including:

                                                              .  smoke, vapors, soot, fumes;
                                                              .  acids, alkalis, chemicals;
</TABLE>

- --------------------------------------------------------------------------------
46156 Rev.9-91 Printed in U.S.A.    Insuring Agreement 5           Page 13 of 22
(C)St. Paul Fire and Marine         Property Coverage
Insurance Co. 1991
<PAGE>

                                                                    THE ST. PAUL

<TABLE>
<S>                                                          <C>
[ILLEGIBLE] from motor vehicles.  We won't cover loss        computer equipment coverage.  This benefits in addition to
through theft or attempted theft from any [ILLEGIBLE]        the limit of coverage for computer equipment shown in the
motor vehicle or trailer.  Such loss [ILLEGIBLE], however,   Coverage Summary.
if theft results from [ILLEGIBLE] into a fully enclosed      Data, media and computer programs.  We'll cover direct
and locked [ILLEGIBLE] containing the property.  The         physical loss or damage to data and media you own or are
[ILLEGIBLE] trailer must show visible signs of forced        legally responsible for.  We'll pay the actual cost of
entry.  This limitation does not apply to [ILLEGIBLE] in     reproducing lost or damage data, provided you actually
the custody of a hired transportation [ILLEGIBLE].           replace or reproduce it, and repairing or replacing the
                                                             damage media with material of the same kind or quality.
Unauthorized instructions.  We won't cover loss resulting
from unauthorized instructions from anyone to transfer       Data means facts, concepts or instructions converted to a
property to any person or place.                             form useable in your data processing operations.  This
                                                             includes computer programs, documentation and source
In addition, the following exclusions under the [ILLEGIBLE]  materials.
Losses We Won't Cover section [ILLEGIBLE] apply to this
coverage:                                                    Media means materials on which data is recorded, such as
 .  [ILLEGIBLE] action;                                       magnetic tapes, disk packs, paper tapes and punch cards.
 .  [ILLEGIBLE] transportation or trade;                      Computer breakdown coverage.  We'll cover the following
 .  [ILLEGIBLE] activity;                                     kinds of direct physical loss to covered computer equipment,
 .  [ILLEGIBLE] deterioration-animals;                        data, media and programs inside your building and to covered
 .  [ILLEGIBLE]                                               air conditioning equipment inside your building and within
 .  [ILLEGIBLE] surrender;                                    1,000 feet of it for:
 .  [ILLEGIBLE] decisions of people;                          .  mechanical breakdown or machinery breakdown; or
 .  [ILLEGIBLE] design, materials, maintenance;               .  short circuit, blow-out, or other electrical damage to
 .  [ILLEGIBLE] inventory loss; and                           electrical equipment, apparatus, or devices, including
                                                             wiring.
[ILLEGIBLE] exclusions under the Exclusions - [ILLEGIBLE]
We Won't Cover section apply to this [ILLEGIBLE].            But we won't cover loss caused by any change in your
                                                             electric power supply, such as interruption, power surge, or
[ILLEGIBLE] Computer Coverage                                brown out, if the change originates more than 1,000 feet
                                                             from the building containing your computer equipment.
[ILLEGIBLE] coverage is indicated in the Coverage Summary,
we'll cover direct physical loss or [ILLEGIBLE] to           Air conditioning.  We'll cover any direct physical loss to
computer equipment which you own, [ILLEGIBLE] from others    your computer equipment caused by corrosion, rust, or
or for which you are [ILLEGIBLE] responsible.                changes in humidity or temperature if your air conditioning
Computer Equipment means a network of [ILLEGIBLE]            system that exclusively services your computer equipment is
components capable of accepting [ILLEGIBLE] from magnetic    damaged by a covered cause of loss.
tapes, disk packs, [ILLEGIBLE] and punch cards, processing
it [ILLEGIBLE] to a plan and producing the desired           Processing.  We'll cover direct physical loss to your
[ILLEGIBLE]Computer equipment includes disks [ILLEGIBLE]     computer equipment, data, media or programs that results
printers, display screens and [ILLEGIBLE] terminals.         during processing operations or while the equipment is being
                                                             worked on or serviced.  The loss or damage must result from
[ILLEGIBLE] media additional benefits.  We'll provide        this processing, [ILLEGIBLE] service.  It
[ILLEGIBLE] benefit in addition to your
</TABLE>

- --------------------------------------------------------------------------------
46156 Rev.9-91 Printed in U.S.A.    Insuring Agreement 5          Page 17 of 22
(C)St. Paul Fire and Marine         Property Coverage
Insurance Co. 1991

<PAGE>

                                                                    The St. Paul

<TABLE>
<S>                                                      <C>
Adjustment Losses                                        Transfer of mortgage holder's right to us.  If we pay
                                                         your mortgage holder for loss or damage that we claim
[ILLEGIBLE] there's a covered loss to your property,     isn't covered by this agreement the mortgage holder's
we will of course, adjust the loss with you.  If         rights to recover that amount from you will then belong
[ILLEGIBLE] a covered loss to someone else's             to us.  But that won't affect your mortgage holder's
property, we'll adjust the loss with you for the         rights to recover the remaining amount of the mortgage
owners account.  Or, we can choose to settle             debt from you.
[ILLEGIBLE] with the owner.  If we settle with the
owner, the owner's release will satisfy any claim        We also have the right to pay off the mortgage debt.
[ILLEGIBLE] make for the same loss.                      If we do, we'll take over the mortgage holder's right
                                                         to be repaid by you.
[ILLEGIBLE] Pay For Loss
                                                         Cancellation notice to mortgage holder.  If we cancel
[ILLEGIBLE]Adjust any loss with you.  However, if the    this agreement, we'll mail or deliver a cancellation
Coverage Summary identifies a person or  [ILLEGIBLE]     notice to your mortgage holder at least 30 days before
to receive payments for covered [ILLEGIBLE], our         coverage ends - 10 days if we cancel for non-payment of
payments will be made to you and [ILLEGIBLE] or          premium.
organization named, based on the financial interest
each has in the covered property described in the        Nonrenewal notice to mortgage holder..  If we elect
Coverage Summary.                                        [ILLEGIBLE] renew this policy, we'll mail or deliver a
                                                         renewal notice to your mortgage holder at least 10 days
If Your Building Is Mortgaged                            before the expiration date of the policy.

If the Coverage Summary identifies a mortgage holder,    Other Rules For This Agreement
this section applies.  We'll consider [ILLEGIBLE] to     -----------------------------
have the same rights and duties as mortgage holders.
                                                         Maintaining your coverage.  You should keep your
[ILLEGIBLE] and duties of mortgage holders.  We'll       building and property in as safe a condition as
make payments for losses to you and any mortgage         possible.  If you are aware of a condition under your
holder based on the interest each has in the covered     control that increases the risk of loss, you should do
property.                                                all you can do to reduce the hazard and notify us of
                                                         this condition.
Any mortgage holder's right to receive payment won't
be affected by foreclosure or other similar              Insurance for your benefit.  This insurance is for your
proceedings.                                             benefit.  No third party having temporary possession of
                                                         your property, such as transportation company, can
[ILLEGIBLE] your claim because of your acts or           benefit directly or indirectly from it.
[ILLEGIBLE] haven't complied with the terms of this
Agreement, the mortgage holder will still have the       Protective safeguards.  You must maintain any
right to receive loss payments if the mortgage holder:   protective safeguards under your control that are
                                                         indicated in your application.  We gave you credit for
 .  [ILLEGIBLE] any premium when due at our request       these safeguards in setting our rates.  If you fail to
[ILLEGIBLE]fail to do so.                                maintain these safeguards, we won't be liable for
 .  [ILLEGIBLE] a signed, sworn statement of loss         losses to the specifically affected areas.  However,
[ILLEGIBLE] fail to do so; and                           your coverage will continue for other areas.
 .  [ILLEGIBLE] when aware of any change in
[ILLEGIBLE] occupancy or risk.                           Buildings that are vacant.  A building is vacant when
[ILLEGIBLE] rules and conditions that apply to you       it does not contain enough business or personal
[ILLEGIBLE] to the mortgage holder.                      property to conduct customary [ILLEGIBLE].
- ---------------------------------------------------------------------------------------------------------------
</TABLE>

46156 Rev. 9-91 Printed in U.S.A.     Insuring Agreement 5         Page 21 of 22
(C)St. Paul Fire and Marine           Property Coverage
Insurance Co. 1991
<PAGE>

                                                                    The St. Paul

<TABLE>
<S>                                                      <C>
Tel [ILLEGIBLE] means transmitting or televising any     Additional payments.  We'll have the duty to make only
audio or visual material by television for any           the payments shown below in connection with any claim
purpose.                                                 or suit we defend.  These payments are in addition to
                                                         the limits of coverage.  But our duty to make such
Medical expenses mean the reasonable expenses incurred   payments ends when we have used up the limits of
by any person or organization for necessary medical      coverage that apply with the payment of judgments,
services received by a person any time during the one    settlements or medical expenses.
year following [ILLEGIBLE] of an event which causes
that person [ILLEGIBLE] bodily injury.                   Our expenses.  We'll pay all expenses we incur.

[ILLEGIBLE] services include:                            Bail bonds.  We'll pay up to $250 for the cost of bail
 .  [ILLEGIBLE] first aid received at the time of an      bonds that are required because of accidents or
event;                                                   violations of traffic laws.  But only if the accidents
 .  ambulance and emergency care services;                or violations result from the use of a vehicle to which
 .  dental, medical, nursing, surgical, x-ray and other   the bodily injury liability coverage under this
health care professional services;                       agreement applies.  We don't have to furnish such bonds.
 .  [ILLEGIBLE] services;
 .  artificial limbs and organs; and                      Bonds to release property.  We'll pay the cost of bonds
 .  funeral services.                                     to release property that's being used to secure a legal
                                                         obligation.  But only for bond amounts within the limit
[ILLEGIBLE] explain what we mean by your products,       of coverage that applies.  We don't have to furnish
[ILLEGIBLE] work and your completed work in the          such bonds.
product recall exclusion.
                                                         Expenses incurred by protected persons.  We'll pay all
[ILLEGIBLE] and duty to defend.  We'll have the right    reasonable expenses that any protected person incurs at
and [ILLEGIBLE] defend any claim or suit for covered     our request while helping us investigate or defend a
[ILLEGIBLE] damage made or brought against any           claim or suit.  But we won't pay more than $250 per day
[ILLEGIBLE] person.  We'll do so even if any of          for earnings actually lost by the protected person
[ILLEGIBLE] of any such claim or suit are [ILLEGIBLE]    because of time taken off from work.
false or fraudulent.  But we have no way to perform
other acts or services.  And [ILLEGIBLE] duty to         Taxed cost.  We'll pay all costs taxed against any
defend claims or suits ends when [ILLEGIBLE] used up     protected person in the suit.
the limits of coverage that [ILLEGIBLE] with the
payment of judgments, settlements or medical expenses.   Pre-judgment interest.  We'll pay the pre-judgment
                                                         interest that's awarded against the protected person on
[ILLEGIBLE] have the right to investigate any claim or   that part of a judgment paid by us.  But if we make a
[ILLEGIBLE] to the extent that we believe is proper.     settlement offer to pay the available limit of
[ILLEGIBLE] also have the right to settle any claim      coverage, we won't pay the pre-judgment interest that
or [ILLEGIBLE] within the available limits of            accumulates after the date of our offer.
coverage.
                                                         Post-judgment interest.  We'll pay all interest that
[ILLEGIBLE] means a demand which seeks damages.          accumulates on the full amount of that part of a
                                                         judgment for which we make a payment.  But only from
[ILLEGIBLE] means a civil proceeding which seeks         the date of the judgment to the date we:
[ILLEGIBLE] includes:
[ILLEGIBLE] proceeding for such damages to [ILLEGIBLE]   .  pay;
protected person must submit or [ILLEGIBLE] with our     .  offer to pay; or
consent; and [ILLEGIBLE] other alternative dispute       .  deposit in court;
resolution [ILLEGIBLE] for such damages to which the
[ILLEGIBLE] person submits with our consent.
</TABLE>
<PAGE>

Injury or damage means bodily injury, [ILLEGIBLE]
injury or property [ILLEGIBLE].

- ------------------------------------------------------------------------------
155  ___ 5-91 Printe_________        Insuring Agreement 51          Page 3 of 16
(C)St. Paul Fire and Marine          Liability Coverage
Insurance Co. 1991
<PAGE>

                                                                    The ST. PAUL

<TABLE>
<S>                                                      <C>
How the limits of coverage apply if the General total    .  parking of an auto on any premises you own, rent,
limit is left blank.  If the amount of the General       lease or borrow, or on ways next to such premises, if
total limit is left blank in the Coverage Summary,       the auto isn't owned, rented, leased or borrowed by any
that total limit will be considered to be the same as    protected person; or
the Each event limit or $100,000, whichever is more.     .  operation of specialized equipment.

    - What This Agreement Won't Cover                    Auto means a land motor vehicle, trailer or semitrailer
- -------------------------------------                    designed for travel on public streets or roads.  It
Advertising, broadcasting, publishing or telecasting     includes any permanently attached machinery or
business.  We won't cover advertising injury             equipment.  But we won't consider mobile equipment to
[ILLEGIBLE] results form an offense committed by any     be an auto.
[ILLEGIBLE] person in the business of advertising,
broadcasting, publishing or telecasting.                 Loading or unloading means the handling of property:
                                                         .  while it's being moved from the place where it's
[ILLEGIBLE].  We won't cover bodily injury, property     accepted for transportation;
[ILLEGIBLE] medical expenses that result from the:       .  while it's being loaded, transported and unloaded;
                                                         and
 .  ownership, maintenance, use or operation;             .  until it's moved to the place where it's finally
 .  [ILLEGIBLE] to others;                                delivered.
 .  [ILLEGIBLE] aircraft owned, operated, rented or
borrowed by any protected person.                        However, we won't consider moving property by an
                                                         unattached mechanical device to be loading or unloading.
[ILLEGIBLE] We won't apply this exclusion to:
 .  [ILLEGIBLE] for bodily injury or property damage      Unattached mechanical device includes any forklift,
assumed under any covered contract for the ownership,    conveyor or other unattached mechanical device, other
maintenance, or use of aircraft; or                      than a hand truck.
 .  [ILLEGIBLE] injury, property damage or medical
expenses that result from the operation of               Entrustment to others means:
[ILLEGIBLE] equipment.                                   .  the permitting of others to use or do something; or
                                                         .  the giving of something to others for safekeeping.
We explain what we mean by entrustment to others and
loading or unloading in the Auto exclusion.              We explain what we mean by mobile equipment and
                                                         specialized equipment in the Mobile equipment exclusion.
[ILLEGIBLE] what we mean by specialized equipment or
the Mobile equipment exclusion.                          Breach of contract.  We won't cover advertising injury
                                                         that results from the failure of any protected person
[ILLEGIBLE] won't cover bodily injury, property damage   to do what is required by a contract or agreement.
or medical expenses that result from [ILLEGIBLE];
                                                         But we won't apply this exclusion to the unauthorized
 .  [ILLEGIBLE] maintenance, use or operation;            taking or use of advertising ideas if the contract or
[ILLEGIBLE] loading; or                                  agreement doesn't specifically prohibit such taking or
                                                         use.
 .  [ILLEGIBLE] to others;
If any auto owned, operated, rented, leased or           Contract liability.  We won't cover the protected
borrowed by any protected person.                        person's liability for injury or damage assumed under
                                                         any contract or agreement.
But we won't apply this exclusion to bodily injury,
property damage or medical expenses that result from     However, we won't apply this exclusion to liability for
the:                                                     injury or damage the protected

- ------------------------------------------------------------------------------------------------------
</TABLE>

[ILLEGIBLE] 155 Ed. 5-91 Printed in U.S.A.   Insuring Agreement 51  Page 7 of 16
St. Paul Fire and Marine Insurance Co. 1991  Liability Coverage
<PAGE>

                                                                    The ST. PAUL

<TABLE>
<S>                                                           <C>
[ILLEGIBLE] refuses to be examined as often as we require,    Construction equipment includes any grader, scraper, roller
within reason, by doctors we choose.                          or power crane, shovel, loader, digger or drill.

[ILLEGIBLE] includes:                                         Specialized equipment means any:
 .  declared or undeclared war, or invasion;                   .  cherry picker or similar device used to lift workers;
 .  warlike action by a military force or other agents of      .  pump, generator or air compressor; or
any government, sovereign or other authority;                 .  other equipment, such as building cleaning, geophysical
 .  [ILLEGIBLE] insurrection, rebellion, revolution or         exploration, lighting, spraying, welding or well-servicing
[ILLEGIBLE] power; or                                         equipment, that has a built-in pump, generator or air
 .  [ILLEGIBLE] to hinder or defend against such               compressor.
[ILLEGIBLE].
                                                              Racing mobile equipment means any mobile equipment while
[ILLEGIBLE] explain what we mean by your products and your    being prepared for or used in any:
completed work in the Products and completed work             .  prearranged racing, speed, demolition or stunting contest
exclusion.                                                    or activity; or
                                                              .  practice for such contest or activity.
Mobile equipment.  We won't cover bodily injury, property
damage or medical expenses that result from the               We explain what we mean by auto, loading or unloading, and
transportation of mobile equipment by an auto owned,          entrustment to others in the Auto exclusion.
operated, rented, leased or borrowed by any protected
person.                                                       Nuclear energy liability  We won't cover bodily injury or
                                                              property damage for which any protected person:
[ILLEGIBLE] we cover bodily injury, property damage or        .  is covered by a nuclear energy liability insurance
medical expenses that result from the use of racing mobile    policy; or
equipment.                                                    .  would have been covered by such policy if that policy's
                                                              limits of coverage hadn't been used up.
Mobile equipment means any land vehicle [ILLEGIBLE]:
 .  designed for use primarily off public streets or roads;    Nor will we cover bodily injury or property damage that
 .  [ILLEGIBLE] for use only on or next to premises you        results from the hazardous properties of nuclear material
[ILLEGIBLE] rent or lease;                                    and for which:
 .  [ILLEGIBLE] on crawler treads;                             .  any person or organization is required by law to maintain
 .  [ILLEGIBLE] kept primarily for the ready movement of       financial protection in accordance with the federal Atomic
permanently attached construction equipment.                  Energy Act, or any of its amendments; or
                                                              .  any protected person is entitled, or would have been
Mobile equipment includes any land vehicle not described      entitled had this agreement not been issued, to indemnity
above that's kept primarily for purposes other than           from the United States government, or any of its agencies,
carrying people or cargo.  [ILLEGIBLE] consider which a       under any contract or agreement between the government, or
vehicle to be [ILLEGIBLE] if it:                              any of its agencies, and any person organization.
 .  [ILLEGIBLE] under its own power;
 .  [ILLEGIBLE] like an auto during travel on a public         We also won't cover medical expenses that result from:
street or road; and                                           .  the hazardous properties of nuclear material; and
 .  [ILLEGIBLE] permanently attached specialized equipment;    .  the operation of a nuclear facility by any person or
or                                                            organization.
[ILLEGIBLE] permanently attached equipment designed
[ILLEGIBLE] removal, street cleaning, or street or road
maintenance - but not construction or [ILLEGIBLE].
</TABLE>

[ILLEGIBLE] 5-91 Printed in U.S.A.      Insuring Agreement 51     Page 11 of 16
St. Paul Fire and Marine                Liability Coverage
Insurance Co. 1991
<PAGE>

                                                                    The ST. PAUL

<TABLE>
<S>                                                           <C>
[ILLEGIBLE] means:                                            Workers' compensation.  We won't cover any obligation that
 .  [ILLEGIBLE] work that you're performing or others are      the protected person has under a workers' compensation
performing for you; or                                        disability benefits or unemployment compensation law, or any
 .  [ILLEGIBLE] that you're providing or others are            similar law.
providing for you.                                            Wrong price description.  We won't cover advertising injury
                                                              that results from making known to any person or organization
[ILLEGIBLE] includes:                                         the wrong description of the price of your products, work or
 .  [ILLEGIBLE] equipment, materials or parts provided with    completed work.
 [ILLEGIBLE] your work;                                       We explain what we mean by your products, your work and your
 .  [ILLEGIBLE] warranty provided with or for your work;       completed work in the Products and completed work exclusion.
 .  [ILLEGIBLE] made, or which should have [ILLEGIBLE] about
 the durability, fitness, [ILLEGIBLE] maintenance,            Other Insurance
 operation, performance, [ILLEGIBLE] safety or use of your    ---------------
 work; and                                                    This Agreement is primary insurance.  If there is any other
 .  [ILLEGIBLE] instructions or directions provided, or        valid and collectible insurance for injury or damage covered
 which should have been provided with or for your work.       by this agreement, the following applies:

We explain what we mean by loading or unloading in the Auto   Other primary insurance.  When there is other primary
 exclusion.                                                   insurance, we'll share any damages with that insurance using
                                                              one of the methods of sharing described in the methods of
[ILLEGIBLE] what we mean by impaired property                 sharing section.
[ILLEGIBLE] impaired property exclusion.
                                                              However, we'll apply this agreement as excess insurance over
[ILLEGIBLE]  We won't cover bodily injury, property damage    any part of any other insurance which provides:
 or medical expenses that result from the:                    .  property or similar coverage for property damage to your
 .  ownership, maintenance, use or operation;                  work;
 .  [ILLEGIBLE] or unloading; or                               .  coverage for property damage to premises you rent, lease
 .  [ILLEGIBLE] to others;                                     or borrow from others; or
 .  [ILLEGIBLE] watercraft owned, operated, rented,            .  coverage for bodily injury or property damage that
[ILLEGIBLE] or borrowed by any protected person.              results from the maintenance, use, operation or loading or
                                                              unloading of any auto, aircraft or watercraft that's not
[ILLEGIBLE] won't apply this exclusion to liability for       specifically excluded by the Auto, Aircraft or Watercraft
bodily injury or property damaged assumed [ILLEGIBLE] any     exclusions.
covered contract for the ownership, maintenance or use of
watercraft.                                                   We explain how we'll apply this agreement as excess
                                                              insurance in the Excess insurance section.
[ILLEGIBLE] we apply this exclusion to bodily [ILLEGIBLE]
property damage or medical expenses [ILLEGIBLE] from:         Excess insurance.  When this agreement is excess insurance,
                                                              we'll have no duty to defend any claim or suit.  However,
[ILLEGIBLE] aircraft you don't own that is less than 50       we'll defend a claim or suit for covered injury or damage if
feet long and isn't being used to carry persons               the other insurers won't.  In return we'll require that
[ILLEGIBLE] for a charge; or operation of specialized
equipment.

We explain what we mean by entrustment to [ILLEGIBLE] and
loading or unloading in the Auto exclusion.

We explain what we mean by specialized equipment in the
Mobile equipment exclusion.
</TABLE>
<PAGE>

- --------------------------------------------------------------------------------
 [ILLEGIBLE]. 5-91 Printed in U.S.A.    Insuring Agreement 51      Page 15 of 16
St. Paul Fire and Marine                Liability Coverage
Insurance Co. 1991
<PAGE>

                                                                    The ST. PAUL

AUTO CONTRACT LIABILITY ENDORSEMENT - MASSACHUSETTS

This endorsement changes your Commercial
[ILLEGIBLE] Protection.

<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------------------------
How Coverage Is Changed                                  Other Terms
<S>                                                      <C>

The following is added to the Auto exclusion under the   All other terms of your policy remain the same.
Exclusions - What This Agreement Doesn't Cover
section.  This change broadens coverage.
We won't apply this exclusion to bodily injury,
property damage or medical expenses that [ILLEGIBLE]
from ability for bodily injury or property damage
assumed under any covered contract for the ownership,
maintenance or use of any auto.


- -----------------------------------------------------------------------------------------------------------------
</TABLE>

[ILLEGIBLE]. 1-89 Printed in U.S.A.            Endorsement
St. Paul Fire and Marine Insurance Co. 1989                        Page __ of __
<PAGE>

                                                                    The ST. PAUL

<TABLE>
<S>                                                            <C>
We [ILLEGIBLE] designed this agreement to protect against      This agreement is excess insurance and covers claims after
 two kinds of liability claims:                                any other insurance that applies to the claim has been used
1.  Claims resulting from bodily injury to others.             up.  Of course there are some limitations which are
2.  Claims resulting from damage to property of others.        explained later in this agreement.

- ---------------------------------------------------------------------------------------------------------------------------
</TABLE>


<TABLE>
<S>                                                            <C>
Table of Contents                                        Page  What This Agreement Covers
                                                               --------------------------

What This Agreement Covers                                  1  Bodily injury and property damage liability.  We'll pay
 [ILLEGIBLE] injury and property damage liability.          1  amounts any protected person is legally required to pay as
 [ILLEGIBLE] on cost or expense.                            1  damages for covered bodily injury or property damage that:
 [ILLEGIBLE] duty to defend.                                2  .  results from the maintenance, use, loading or unloading
 Additional payments.                                       3  of a covered auto; and
 Right to appeal.                                           3  .  is caused by an accident that happens while this
 Out of state coverage.                                     3  agreement is in effect.

What Autos Are Covered                                      3  Pollution cost or expense.  We'll pay amounts any protected
 Hired autos                                                4  person is legally required to pay as covered pollution cost
 Nonowned autos                                             4  or expense only if it results from an accident which also
                                                               causes bodily injury or property damage covered by this
When This Agreement Covers                                  4  agreement.

Where This Agreement Covers                                 4  Protected person means any person or organization who
                                                               qualifies as a protected person under the Who Is Protected
Who Is Protected Under This Agreement                       4  Under This Agreement section.
 Individual.                                                4
 Partnership or joint venture.                              4  Bodily injury means any physical harm, including sickness or
 Corporation or other organization.                         4  disease, to the physical health of other persons.  It
 Any permitted user.                                        4  includes any of the following that results at any time from
 Anyone legally responsible for the actions of a               such physical harm, sickness or disease:
  protected person.                                         4  .  Mental anguish, injury or illness.
 [ILLEGIBLE] of protected persons.                          5  .  Emotional distress.
                                                               .  Care, loss of services or death.
Limit Of Coverage                                           5
                                                               Property damage means
Exclusions - What This Agreement Won't Cover                5  .  physical damage to tangible property of others, including
 Contract liability.                                           loss of use of such property; or
 [ILLEGIBLE] property.                                      5  .  loss of use of tangible property of others that isn't
 [ILLEGIBLE] liability                                      6  physically damaged.
 Injury to a fellow employee.                               6
 Intentional or expected bodily injury or property          6  We'll consider all loss of use of tangible property to
 damage.                                                    6  happen at the time of the accident which caused it.
 [ILLEGIBLE] energy liability.                              6
 [ILLEGIBLE].                                               7  Accident includes continuous or repeated exposure to the
 [ILLEGIBLE] equipment.                                     8  same conditions.
 [ILLEGIBLE] compensation.                                  8

Other Insurance
Insurance provided by another insurer.  Insurance           8
 provided under another policy with us or any of our        9
 member insurance companies.
                                                            9
- ------------------------------------------------------------------------------------------------------------------------------------
</TABLE>

 44471 Ed. 4-91Printed in U.S.A.     Insuring Agreement 63
 (C)St. Paul Fire and Marine
 Insurance Co. 1991 All Rights Reserved                         Page 1 of 9
<PAGE>

                                                                     The St Paul


<TABLE>
<S>                                                           <C>
The person causes an accident which results in covered        to substantially the same conditions to be the result of one
bodily injury and property damage.  We'll consider you,       accident.
that employee, and the other company that employs the
other person to be protected persons.                         Exclusions - What This Agreement Won't Cover
                                                              --------------------------------------------
Be we won't consider the owner or anyone else from whom you
rent, lease, hire or borrow a [ILLEGIBLE] auto to be a        Contract liability.  We won't cover the protected person's
protected person unless [ILLEGIBLE] connected to a covered    liability for bodily injury or property damage assumed under
auto [ILLEGIBLE].                                             any contract or agreement.

[ILLEGIBLE] of protected persons.  We'll apply this           However, we won't apply this exclusion to liability for
agreement:                                                    bodily injury or property damage the protected person would
                                                              have without the contract or agreement.  Nor will we apply
[ILLEGIBLE] each protected person named in the Introduction   this exclusion to the protected person's liability for
as if that protected person was the only [ILLEGIBLE] named    bodily injury or property damage assumed under a covered
there; and                                                    contract made before the bodily injury or property damage
                                                              happens.
[ILLEGIBLE] to each other protected person.
                                                              Covered contract means any:
However, the limit of coverage shown in the Coverage          .  lease of premises;
Summary is shared by all protected [ILLEGIBLE]. We explain    .  sidetrack agreement;
how in the Limits Of [ILLEGIBLE] Section.  Also, any right    .  easement or license agreement;
or duty specifically assigned to the first Name Insured       .  obligation to indemnify a municipality if the obligation
remains unchanged.  We explain those rights [ILLEGIBLE]          is required by ordinance and isn't connected with work for
duties in the General Rules, which is a part of your             the municipality;
policy.,                                                      .  contract or agreement under which you assume the tort
                                                                 liability of a municipality to pay damages for covered
Limit of Coverage                                                bodily injury or property damage that is sustained by others
- -----------------                                                and results from work for the municipality ;
                                                              .  other contract or agreement under which you assume the
The Coverage Summary shows the limit of coverage that            tort liability of another to pay damages for covered bodily
applies to this agreement.                                       injury or property damage that's sustained by others; or
                                                              .  contract or agreement which you or any of your employees
[ILLEGIBLE] each accident limit is the most we'll pay for        enter into for the rental or lease of any auto.
[ILLEGIBLE] total of all covered bodily injury, property
damage and pollution cost or expense that results from any    Tort liability means a liability that would be imposed by
one accident.  This limit applies regardless of the           law without any contract or agreement.
premiums paid or [ILLEGIBLE] of:
                                                              But we won't consider the following parts of any contract or
 .  protected persons;                                         agreement to be a covered contract:

 .  premiums paid;                                             Auto with driver.  That part which has to do with the
                                                              rental, lease or loan of an auto to you or any of your
 .  claims made or suits brought;                              employees if the auto is rented, leased or loaned with a
                                                              driver.
 .  covered autos;

[ILLEGIBLE] involved in the accident; or persons or
organizations making claims or bringing suits.

[ILLEGIBLE] consider all covered bodily injury, property
[ILLEGIBLE] and pollution cost or expense that
[ILLEGIBLE] from continuous or repeated exposure
- ------------------------------------------------------------------------------------------------------------------------------------
</TABLE>

 44471 Ed. 4-91 Printed in U.S.A.        Insuring Agreement 63
 (C)St. Paul Fire and Marine
 Insurance Co. 1991 All Rights Reserved                             Page 5 of 9

<PAGE>

                                                                     THE ST PAUL

<TABLE>
<S>                                                           <C>
Other Insurance                                               excess basis as this agreement, we'll pay only our share of
- ---------------
This agreement provides excess insurance for covered autos    your accident.  We'll pay the same proportion of such
you don't own.                                                damages or pollution cost or expense that our limit is to
                                                              the total of all [ILLEGIBLE] policy limits.  But we won't
Excess insurance applies after other collectible insurance    pay more than our limit.
has been used up.

This agreement is primary insurance for liability for         Insurance provided under another policy with us [ILLEGIBLE]
covered bodily injury or property damage assumed under a      of our member insurance companies.
coverage contract.                                            [ILLEGIBLE] this agreement and other insurance contained in
                                                              a policy from us or another member insurance company of The
We explain what we mean by covered contract in the Contract   St. Paul Group both apply to the same accident, the
liability exclusion.                                          [ILLEGIBLE] we will pay is the highest limit of coverage
                                                              that applies under any one policy.  When [ILLEGIBLE]
Insurance provided by another insurer.  When insurance        insurance written by us or the member insurance company is
provided by another insurer applies to covered bodily         intended to be excess of this agreement, this section does
injury or property damage that results from an accident on    not apply.
the same primary or
</TABLE>


44471 Ed. 4-91 Printed in U.S.A.  Insuring Agreement 63
(C)St. Paul Fire and Marine Insurance Co. 1991 All Rights Reserved   Page 9 of 9
<PAGE>

                                  COVER PAGE



                        WAVERLY INSURANCE AGENCY, INC.
                          COMPLETE INSURANCE SERVICE


                     493 Trapelo Road . Belmont, MA 02178
                                (619) 484-5216
<PAGE>

                      Eastern Casualty Insurance Company

         WORKERS COMPENSATION AND EMPLOYERS LIABILITY INSURANCE POLICY
                               INFORMATION PAGE


<TABLE>
<S>                                                    <C>
NCCI Carrier 16942                                     Risk I.D. # ____________

Policy No. WC P0007199                                 Federal I.D. # 77-____________

1.  The Insured/Mailing address:                       [_] Individual  [_] Partnership

     SEQUENOM INC.                                     [_] Corporation or ___________
     101 ARCH STREET SUITE 1950                        ______________________________
     BOSTON, MA 021110
Other workplaces not shown above:

2.  Policy Period:  The policy period is from 10/27/94 to 10/27/95     12:01 A.M. Standard Time,
                              at the insured's mailing address.

3.  Coverage:
    A.  Worker's Compensation Insurance: Part One of the policy applies to the
        Workers Compensation Law of the states listed here: Massachusetts

    B.  Employers Liability Insurance:  Part Two of the policy applies to work in each state listed in item 3.A.
        The limits of our liability under Part Two are:  Bodily Injury by Accident  100,000 each accident
                                                         Bodily Injury by Disease   500,000 policy limit
                                                         Bodily Injury by Disease   100,000 each employee
    C.  Other States Insurance:  Part Three of the policy applies to the states, if any, listed here:  See
        Endorsement WC 20 03___, WC242, WC332, WC350, WC367, WC441

    D.  This policy includes these endorsements and schedules:
        See Information Page III for other applicable endorsements.


Total Estimated Annual Premium   $   1,489
Pro Rata Premium (If Applicable) $

               ANNUAL

Countersigned  WAVERLY INSURANCE AGENCY
               493 TRAPELO ROAD
               BELMONT, MA 02178

Date  01-10-95                                           By  /s/
                                                             ----------------------------------
      ARC:  104.33                                                     Authorized Signature
</TABLE>

  THIS INFORMATION PAGE WITH THE WORKERS COMPENSATION AND EMPLOYERS LIABILITY
       INSURANCE POLICY AND ENDORSEMENTS, IF ANY, ISSUED TO FORM A PART
                  THEREOF COMPLETES THE ABOVE NUMBERED POLICY
<PAGE>

                      Eastern Casualty Insurance Company
- --------------------------------------------------------------------------------
                                                                           WC174
                                                                      (Ed. 4-84)

         WORKERS COMPENSATION AND EMPLOYERS LIABILITY INSURANCE POLICY
                         EXTENSION OF INFORMATION PAGE

Policy Number:  WCP0007199                                  SEQUENOM

4.  Premium: The premium for this policy will be determined by our Manuals of
             Rules, Classification, Rates and Rating Plans. All information
             required below is subject to verification and change by audit.

<TABLE>
<CAPTION>
                        Classifications                           Code     Premium Basis       Rate Per    Estimated Annual
                                                                  No.     Total Estimated      $100 of         Premiums
                                                                        Annual Remuneration  Remuneration
- ------------------------------------------------------------------------------------------------------------------------------
<S>                                                               <C>   <C>                  <C>           <C>
ANALYTICAL CHEMISTS                                               4511          98,000          1.28             1,254
CLERICAL OFFICE EMPLOYEES                                         8810          10,400           .33                34
COVERAGE B-EMPLOYERS LIABILITY                                    9345                                               0
STANDARD PREMIUM SUBJECT TO DIA                                                                               [ILLEGIBLE]

EXPENSE CONSTANT                                                  0900                                             160
DIA ASSESSMENT 3.2% OF STANDARD PREMIUM                                                                             41




- ------------------------------------------------------------------------------------------------------------------------------
Minimum Premium $  135                                                   Total Estimated Annual Premium:    $    1,439
                                                                         Pro-Rata Premium (if applicable):  $
                                                                                   ANNUAL
</TABLE>

                                 INSURED COPY
<PAGE>

                       Eastern Casualty Insurance Company


INFORMATION PAGE III                         POLICY NO. WCP0007199
                                                        ----------
These endorsements apply only if so indicated by an "X" in the box below.

[_]  WC100       Defense Base Act Endorsement

[_]  WC103       Federal Employers' Liability Act Endorsement

[_]  WC111       Voluntary Compensation Maritime Coverage Endorsement

[_]  WC113       Designated Workplaces Exclusion Endorsement

[_]  WC124       Waiver of Our Right to Recover from Others Endorsement

[_]  WC127       Anniversary Rating Date Endorsement

[_]  WC128       Experience Rating Modification Factor Endorsement

[_]  WC129       Pending Rate Change Endorsement

[_]  WC131       Premium Discount Endorsement

[_]  WC132       Rate Change Endorsement

[_]  WC133       Retrospective Premium Endorsement (I, II, III, IV-One Year)

[_]  WC137       Retrospective Premium Endorsement
                 Rating Option V -- One Year Plan

[_]  WC236       Domestic and Agricultural Workers Exclusion Endorsement

[_]  WC269       Alternate Employer Endorsement

[_]  WC331       Aircraft Premium Endorsement

[_]  WC418       Massachusetts Qualified Loss Management Program Endorsement

[_]  WC419       Longshore & Harborworkers Act Endorsement

[_]  WC421       Outer Continental Shelf Lands Act Coverage Endorsement

[_]  WC422       Maritime Coverage Endorsement

[_]  WC443       MA Exclusion of Coverage for Leased Employers Endorsement

[_]  WC444a      Massachusetts Employee Leasing Endorsement

[_]  WC474       Massachusetts Benefits Deductible Endorsement


                                    INSURED
<PAGE>

   WORKERS COMPENSATION AND EMPLOYERS LIABILITY INSURANCE POLICY     WC 20 03 06


                                  WC 20 03 06
                  MASSACHUSETTS LIMITED OTHER STATES INSURANCE

This endorsement changes the policy to which it is attached effective on the
inception date of the policy unless a different date is indicated below.
(The following "attaching clause" need to be completed only when this
endorsement is issued subsequent to preparation of the policy)

This endorsement, effective on    10/27/94  at 12:01 A.M. standard time, forms
                                  (Date)
a part of

Policy No. WCP007199       of the        Eastern Casualty Insurance Company
                                              (Name of Insurance Company)

issued to SEQUENOM INC.

Premium $   1,448.00                    ____________________________________
                                              Authorized Representative


"PART THREE - OTHER STATES INSURANCE" is amended to read:

A. How This Insurance Applies:

   1. We will pay promptly, when due, the benefits required of you by the
      workers' compensation law of any state other than Massachusetts, but only
      if the claim for such benefits involves work performed by a Massachusetts
      employee.

   2. If we are not permitted to pay the benefits directly to persons entitled
      to them under circumstances described in item 1 above, we will reimburse
      you for the benefits required to be paid.


                               IMPORTANT NOTICE


If you hire any employees outside Massachusetts or begin operations in any state
other than Massachusetts, you must obtain insurance coverage in that state and
so whatever else may be required under that state's law, as this endorsement
does not satisfy the requirements of that state's workers' compensation law.



                                    Copyright 1994
                                    National Council on Compensation Insurance


                                    [LOGO]
<PAGE>

                                  EXHIBIT 6.6
                                  -----------

                      Form of Stock Restriction Agreement
                      -----------------------------------
<PAGE>

                          STOCK RESTRICTION AGREEMENT

     This Agreement made as of December 22, 1995 by and among Sequenom, Inc., a
Delaware corporation (the "Corporation"); Hubert Koster ("Koster"), Nola E.
Masterson ("Masterson") and Robert E. Patterson ("Patterson," and together with
Koster and Masterson, the "Founders"); and the purchasers of shares of the
Corporation's Series B Convertible Preferred Stock, par value $.001 per share
("Series B Preferred Stock"), pursuant to the Series B Convertible Preferred
Stock Purchase Agreement dated as of the date hereof (the "Purchase Agreement"),
including any Additional Investors as defined in the Purchase Agreement (such
purchasers being hereinafter referred to as the "Investors").

                          W I T N E S S E T H  T H A T

     WHEREAS, the Investors wish to purchase from the Corporation certain shares
of Series B Preferred Stock;

     WHEREAS, the Investors' purchase of the Series B Preferred Stock would
materially benefit the Founders as holders of certain shares of the
Corporation's capital stock and rights to acquire such capital stock;

     WHEREAS, it is a condition to the obligations of the Investors under the
Purchase Agreement that this Agreement be executed by the Founders, and the
Founders are willing to execute this Agreement and to be bound by the provisions
hereof;

     NOW, THEREFORE, in consideration of the foregoing, the agreements set forth
below, and the parties', desire to provide for continuity of ownership of the
Corporation to further the interests of the Corporation and its present and
future stockholders, the parties hereby agree with each other as follows:

     1.  Certain Defined Terms.  As used in this Agreement, the following terms
         ---------------------
shall have the following respective meanings:

         (a) "Stock" shall mean and include all shares of the Corporation's
Common Stock, par value $.001 per share ("Common Stock"), any evidences of
indebtedness, shares of capital stock or other securities directly or indirectly
convertible into or exchangeable for Common Stock ("Convertible Securities"),
including without limitation the Series A Convertible Preferred Stock, par value
$.001 per share, of the Corporation, and any rights, options or warrants to
subscribe for, purchase or otherwise acquire Common Stock or Convertible
Securities ("Options"), and all other securities of the Corporation which may be
issued in exchange for or in respect of shares of Common Stock, Convertible
Securities or Options (whether by way of stock split, stock dividend,
combination of shares, reclassification, recapitalization, reorganization, or
any other means).

         (b) "Shares" shall mean and include all shares of Stock now owned or
hereafter acquired by any Founder or any investor.
<PAGE>

     2.   Prohibited Transfers.  None of the Founders shall sell or otherwise
          --------------------
transfer, by gift or otherwise, all or any part of his Shares except in
compliance with the terms of this Agreement.

     3.   Offer of Sale; Notice of Proposed Sale or Transfer.  If any Founder
          --------------------------------------------------
desires to sell or otherwise transfer any of his Shares, or of any interest
therein, whether voluntarily or by operation of law, in any transaction other
than pursuant to clauses (iii) or (iv) of Section 7(a) of this Agreement, such
Founder (the "Selling Founder") shall first deliver written notice of his desire
to do so (the "Notice") to the Corporation and each of the Investors.  The
Notice must specify:  (i) the name and address of the party to which the Selling
Founder proposes to sell or otherwise transfer the Shares or an interest in the
Shares (the "Proposed Transferee"), (ii) the number of Shares the Selling
Founder proposes to sell or otherwise transfer (the "Offered Shares"), (iii) the
consideration per Share to be delivered to the Selling Founder for the proposed
sale or transfer, and (iv) all other material terms and conditions of the
proposed transaction, which must be bona fide.

     4.   Corporation's Option to Purchase.
          --------------------------------

          (a) Except as set forth in Section 7(a), the Corporation shall have
the first option to purchase all or any part of the Offered Shares for the
consideration per Share and on the terms and conditions specified in the Notice.
The Corporation must exercise such option, no later than fifteen (15) business
days after such Notice is deemed to have been delivered to it, by written notice
to the Selling Founder.

          (b) In the event the Corporation does not exercise its option within
such fifteen-business-day period with respect to all of the offered Shares, the
Chief Financial officer of the corporation shall, by the last day of such
period, give written notice of that fact to the Investors (the "Investor
Notice").  The Investor Notice shall specify the number of Offered Shares the
Corporation has elected not to purchase (the "Remaining Shares").

          (c) In the event the Corporation duly exercises its option to purchase
all or a portion of the Offered Shares, the closing of such purchase shall take
place at the offices of the Corporation on the later of (i) the date five
business days after the expiration of such fifteen-business-day period or (ii)
the date that the Investors consummate their purchase of Offered shares under
Section 5(c) hereof.

          (d) To the extent that the consideration proposed to be paid by the
Proposed Transferee for the Offered Shares consists of property other than cash
or a promissory note, the consideration required to be paid by the Corporation
and/or the Investors exercising their options under Sections 4 and 5 hereof,
respectively, may consist of cash equal to the value of such property, as
determined in good faith by agreement of the selling Founder and the Corporation
and/or the Investors acquiring such Offered Shares.

                                      -2-
<PAGE>

     5.   Investors' Option to Purchase and Right to Participate in Sales.
          ---------------------------------------------------------------

          (a) Except as set forth in Section 7(a), each Investor shall have an
option, exercisable for a period of fifteen (15) business days from the date of
delivery of the Investor Notice, to purchase, on a pro rata basis, its
Proportionate Percentage (as defined below) of the Remaining Shares, for the
consideration per Share and on the terms and conditions set forth in the Notice.
Such option shall be exercised by delivery of written notice to the Chief
Financial Officer of the Corporation.  Alternatively, each Investor may, within
the same fifteen-business-day period, notify the Chief Financial Officer of the
Corporation of its desire to participate in the sale of Shares and to sell, on
the terms as set forth in the Notice including at the same price per share on a
common equivalent basis, up to an equivalent proportion of the Stock owned by
such Investor as the proposed sale of the Remaining Shares represents with
respect to the Shares then owned by the Selling Founder.

          (b) In the event options to purchase have been exercised by the
Investors with respect to some but not all of the Remaining Shares, the Chief
Financial Officer of the Corporation shall promptly give written notice of that
fact to those Investors who have exercised their options within such period (the
"Second Investor Notice").  The Second Investor Notice shall specify the number
of Remaining Shares the Investors have not elected to purchase.  The Investors
who have exercised their options within the fifteen-business-day period
specified in Section 5(a) shall have an additional option, for a period of ten
(10) business days after delivery of the Second Investor Notice, to purchase all
or any part of the balance of such Remaining Shares on the terms and conditions
set forth in the Notice, which option shall be exercised by the delivery of
written notice to the Chief Financial Officer of the Corporation.  In the event
that there are two or more such Investors that choose to exercise the last-
mentioned option for a total number of Remaining Shares in excess of the number
available, the Remaining Shares available for each such Investor's option shall
be allocated to such Investors pro rata based on the amount of Stock owned by
the Investors so electing on a common equivalent basis.

          (c) Promptly after the expiration of the last period for exercise of
an Investor's purchase option, the Chief Financial Officer of the Corporation
shall give written notice to the Selling Founder and the purchasing Investors,
specifying the number of Remaining Shares to be purchased by each purchasing
Investor.  The closing of the purchase of the Remaining Shares shall take place
at the offices of the Corporation no later than five (5) business days after
delivery of such notice to the Selling Founder and the purchasing Investors.

          (d) As used in this Section 5, the term "Proportionate Percentage"
shall mean with respect to each Investor a fraction, the numerator of which
shall be the amount of Stock owned by such Investor, and the denominator of
which shall be the total amount of Stock owned by all Investors, in each case on
a common equivalent basis.

     6.   Co-Sale.
          -------

          (a) If the Corporation and the Investors do not exercise their options
to purchase all of the Offered Shares within the periods described in this
Agreement (the "Option Period"), then each Investor which has, pursuant to
Section 5(a), expressed a desire to sell shares

                                      -3-
<PAGE>

in the transaction (a "Participating Investor") shall be entitled to do so
pursuant to this Section. The Chief Financial Officer of the Corporation shall
promptly, on expiration of the Option Period, notify the Selling Founder of the
aggregate amount of Stock the Participating Investors wish to sell. The Selling
Founder shall use his best efforts to interest the Proposed Transferee in
purchasing, in addition to the Remaining Shares not subscribed for by the
Investors, the Stock the Participating Investors wish to sell. If the Proposed
Transferee does not wish to purchase all of the Stock made available by the
Selling Founder and the Participating Investors, then each Participating
Investor and the Selling Founder shall be entitled to sell, on the terms and
conditions set forth in the Notice and on the same price per share on a common
equivalent basis, a portion of the Stock being sold to the Proposed Transferee,
in the same proportion as such Selling Founder or Participating Investor's
ownership of Stock on a common equivalent basis bears to the aggregate amount of
Stock owned by the Selling Founder and the Participating Investors on a common
equivalent basis. The transaction contemplated by the Notice shall be
consummated not later than 60 days after the expiration of the Option Period.

          (b) If the Participating Investors do not elect to sell the full
amount of Stock which they are entitled to sell pursuant to Section 6(a), the
Selling Founder shall be entitled to sell to the Proposed Transferee, according
to the terms set forth in the Notice, that number of his Shares which equals the
difference between the amount of Stock desired to be purchased by the Proposed
Transferee and the number of Shares the Participating Investors wish to sell, in
each case on a common equivalent basis.

          (c) If the Selling Founder wishes to sell or otherwise transfer any of
his Shares at a price per Share which differs from that set forth in the Notice,
upon terms different from those previously offered to the Corporation and the
Investors, or more than 60 days after the expiration of the Option Period, then,
as a condition precedent to such transaction, such Shares must first be offered
to the Corporation and the Investors on the same terms and conditions as given
the Proposed Transferee, and the Investors must first be offered the opportunity
to participate in such transaction, in accordance with the procedures and time
periods set forth above.

     7.   Permitted Transfers.
          -------------------

          (a) Subject to the provisions of Section 7(b) and Section 8, the
Corporation's and the Investors' right of first refusal and the Investors' right
of co-sale described in Sections 4 through 6 shall not apply to:  (i) any
transfer of Shares by a Founder by gift or bequest or through inheritance to, or
for the benefit of, any member or members of such Founder's immediate family;
(ii) any transfer of Shares by an Founder to a trust (A) in respect of which
such Founder serves as trustee, provided that the trust instrument governing
such trust shall provide that such Founder, as trustee, shall retain sole and
exclusive control over the voting and disposition of such Shares until the
termination of this Agreement or (B) for the benefit solely of any member or
members of such Founder's immediate family; (iii) any sale or transfer of Shares
to the Corporation; (iv) any underwritten public offering of Common Stock
pursuant to an effective registration statement under the Securities Act of
1933, as amended (the "Securities Act"); and (v) with respect to sales or other
transfers of up to an aggregate of the following number of shares (as adjusted
to reflect any stock split, stock dividend, combination of shares or other

                                      -4-
<PAGE>

similar transaction), but subject in any case to the restrictions set forth in
Section 8:  (A) in the case of each of Koster and Masterson, 130,000 Shares; and
(B) in the case of Patterson, 50,000 Shares;

          (b) In the event of any sale or transfer described in clauses (i) or
(ii) of Section 7(a), the transferee of the Shares shall hold the Shares so
acquired subject to all the restrictions imposed by this Agreement and shall be
deemed a Founder for all purposes hereof, and as a condition to such transfer,
any such transferee shall, at the request of the Corporation or any Investor,
execute and deliver a written instrument agreeing to be bound by the provisions
of this Agreement.

     8.   Consent of the Corporation to Transfer.  As a condition to selling or
          --------------------------------------
otherwise transferring any Shares proposed to be sold or transferred by the
Selling Founder and any Participating Investor to any Proposed Transferee, other
than a sale or transfer described in clause (iii) or (iv) of Section 7(a), the
Selling Founder shall have obtained the written consent to such transfer by the
Board of Directors of the Corporation by majority vote at a meeting or by
unanimous consent in lieu of a meeting.  Such consent shall not be unreasonably
withheld, and shall be based on the Board of Directors' determination, after
such inquiry as it deems appropriate, but within thirty days of the date of the
Selling Founder's notice to the Corporation under Section 3, that the Proposed
Transferee is not a competitor of the Corporation and is not otherwise an
inappropriate investor in the Corporation.  In the event the Selling Founder
disagrees with such determination, and the Board of Directors and the Selling
Founder are unable to resolve the disagreement, an independent third party
selected and agreed upon by the Board of Directors and the Selling Founder shall
arbitrate and finally resolve the disagreement.

     9.   Lock-up.  Each Founder agrees that upon the request of the Corporation
          -------
or the underwriters managing an underwritten offering of the Corporation's
securities, such Founder will not sell, make any short sale or loan of, grant
any option for the purchase of, or otherwise dispose of any Shares held by him
without the prior written consent of the Corporation or such underwriters, as
the case may be, for a period of up to 180 days from effective date of the
applicable registration statement.

     10.  Sale or Transfer in Violation of this Agreement.  If any sale or other
          -----------------------------------------------
transfer of Shares is made or attempted in violation of any provision of this
Agreement, or if any Shares are not offered to the Corporation or the Investors
as required hereby, the Corporation and the Investors, as the case may be, shall
have the right to purchase such Shares from the owner thereof or his transferee
at any time before or after the transfer, as herein provided.  In addition to
any other legal or equitable remedies which it or they may have, the Corporation
and the Investors may enforce their respective rights hereunder by actions for
specific performance (to the extent permitted by law).  The Corporation shall
not be required (i) to transfer on its books any Shares or other Stock which has
been sold or transferred in violation of any provision of this Agreement or (ii)
to treat as the owner of such Shares or Stock, or to pay dividends to, any
transferee to whom any such Shares or Stock have been so sold or transferred.
If a Founder becomes obligated to sell any Shares to the Corporation under this
Agreement and fails to deliver such Shares in accordance with the terms of this
Agreement, the Corporation may, at its option, in addition to all other remedied
it may have, send to such Founder the purchase price for such

                                      -5-
<PAGE>

Shares as is herein specified and cancel on its books the certificate or
certificates representing the Shares to be sold. Thereafter, all of the
Founder's rights in and to such Shares shall terminate.

     11.  Disposition of Shares.  Any Shares that the Corporation elects to
          ---------------------
purchase hereunder may be disposed of by it in such manner as it deems
appropriate with or without restrictions on the transfer thereof, and the
Corporation may require their transfer to a nominee or designee as part of any
purchase of the Shares from the Founders.

     12.  Restrictive Legend.  All certificates representing Shares held by the
          ------------------
Founders which are subject to this Agreement shall have affixed thereto a legend
in substantially the following form, in addition to any other legends that may
be required by the Corporation in connection with compliance with federal or
state securities laws or otherwise:

          "The shares of stock represented by this certificate are
          subject to restrictions on transfer and/or an option to
          purchase set forth in a Stock Restriction Agreement between
          the Corporation and the registered owner of the shares
          represented by this certificate (or his predecessor in
          interest). The Corporation will furnish a copy of such
          agreement to the holder of this certificate upon written
          request without charge."

The Founders shall cause such legend to be affixed to any of such certificates
not so legended.

     13.  Term.  This Agreement shall terminate upon the closing of a firm
          ----
commitment underwritten public offering of Common Stock pursuant to an effective
registration statement under the securities Act in which (i) the public offering
price per share is not less than $4.50 (appropriately adjusted to take account
of any stock split, stock dividend, combination of shares or similar event) and
(ii) the aggregate gross proceeds to the Corporation are not less than
$10,000,000.

     14.  Specific Enforcement.  Each Founder expressly agrees that a violation
          --------------------
of this Agreement by such Founder could not be adequately compensated by money
damages alone and that the Investors and the Corporation will be irreparably
damaged if this Agreement is not specifically enforced.  Upon a breach or
threatened breach of the terms, covenants and/or conditions of this Agreement by
any Founder, the Investors and the Corporation shall, in addition to all other
remedies, each be entitled to a temporary or permanent injunction, and/or a
decree for specific performance, in accordance with the provisions hereof.

     15.  Other Agreements.  The restrictions on the Founders' right to dispose
          ----------------
of their Shares pursuant to this Agreement are in addition to and to be
construed consistently with the Founders' rights and obligations (including
restrictions on the Founders' right to dispose of shares of the Corporation's
capital stock) contained in any other agreement relating to restrictions on the
transferability of such Shares that the Founders execute before, on, or after
the date hereof; provided, that this Agreement shall supersede and replace (i)
the Stock Restriction Agreement dated October 16, 1995 between the Corporation
and Nola E. Masterson, which shall

                                      -6-
<PAGE>

no longer be of any force or effect, and (ii) the form of Stock Restriction
Agreement attached to the outstanding options to purchase Common Stock held by
Koster and Patterson.

     16.  Waiver, Modification and Termination.  No provision of this Agreement
          ------------------------------------
shall be deemed to have been waived by the corporation or any Investor in the
absence of a written agreement executed by such party with respect to such
waiver.  This Agreement may be modified or terminated only with the written
consent of the Founders, the Corporation, and the holders of a majority in
voting power of the Shares then held by the Investors.

     17.  Accession.  Any Additional Investors as defined in the Purchase
          ---------
Agreement shall automatically become an Investor hereunder by delivering to the
Corporation a written instrument in the form of Exhibit A hereto, by which such
                                                ---------
Additional Investor agrees to be bound by the obligations imposed under this
Agreement, whereupon such Additional Investor shall automatically become a party
to this Agreement and shall thereupon be deemed an "Investor" for all purposes
of this Agreement.

     18.  Binding Effect; Assignment.  This Agreement shall be binding upon the
          --------------------------
parties hereto and their heirs, legal representatives, successors and assigns.
The rights and obligations of the Founders hereunder may not be assigned or
delegated without the written consent of the Corporation.

     19.  Notices.  All notices, requests, consents, deliveries and other
          -------
communications hereunder shall be in writing and shall be delivered in person or
duly sent by first class mail, postage prepaid, or by any internationally
recognized express courier service, to the Corporation at its principal place of
business, and to the Investors and the Founders at their respective last known
address or at their respective address, if any, appearing on the books of the
Corporation.

     20.  Severability.  If any provision of this Agreement shall be held to be
          ------------
illegal, invalid or unenforceable, such illegality, invalidity or
unenforceability shall attach only to such provision and shall not in any manner
affect or render illegal, invalid or unenforceable any other provision of this
Agreement, and this Agreement shall be carried out as if any such illegal,
invalid or unenforceable provision were not contained herein.

     21.  Governing Law.  This Agreement shall be governed by, and construed and
          -------------
enforced in accordance with, the substantive law of The Commonwealth of
Massachusetts, without regard to its principles of conflicts of laws.

     22.  Captions.  Captions are for convenience only and are not deemed to be
          --------
part of this Agreement.

     23.  Counterparts.  This Agreement may be executed in one or more
          ------------
counterparts, each of which shall be deemed an original and all of which
together shall constitute a single instrument.  Each such counterpart may
contain one or more signature pages.

                                      -7-
<PAGE>

     IN WITNESS WHEREOF, the parties hereto have executed this Agreement as a
contract under seal as of the day and year first above written.

                              SEQUENOM, INC.

                              By:  ______________________________________


                              FOUNDERS:

                              ___________________________________________
                              Hubert Koster


                              ___________________________________________
                              Nola E. Masterson


                              ___________________________________________
                              Robert E. Patterson

                                      -8-
<PAGE>

                                 SEQUENOM, INC.

                          Stock Restriction Agreement

                            Investor Signature Page
                            -----------------------


     By executing this page in the space provided, the undersigned hereby agrees
(i) that it is an "Investor" as defined in the Stock Restriction Agreement dated
as of _______, 1995, by and among Sequenom, Inc. and the parties named therein,
(ii) that it is a party to the Stock Restriction Agreement for all purposes and
(iii) that it is bound by all terms and conditions of the Stock Restriction
Agreement.


     EXECUTED this ____ day of __________, 1995.


                              ___________________________________________
                              (print name)


                              By:   _____________________________________

                              Title:  ___________________________________

                              Address:  _________________________________
<PAGE>

                                   Exhibit A
                                   ---------

                                 SEQUENOM, INC.

                          Stock Restriction Agreement

                       Additional Investor Signature Page
                       ----------------------------------

     By executing this page in the space provided, the undersigned hereby agrees
(i) that it is an "Additional Investor" as defined in the Series B Convertible
Preferred Stock Purchase Agreement dated as of December 22, 1995 and an
"Investor" as defined in the Stock Restriction Agreement dated as of __________
__, 1995, each by and among Sequenom, Inc. and the parties named therein, (ii)
that it is a party to the Stock Restriction Agreement for all purposes and (iii)
that it is bound by all terms and conditions of the Stock Restriction Agreement.

     EXECUTED this __ day of __________, 1995.


                              ___________________________________________
                              (print name)


                              By:  ______________________________________

                              Title:  ___________________________________

                              Address: __________________________________
<PAGE>

                                 EXHIBIT 4.16A
                                 -------------


                     Form of Registration Rights Agreement
                     -------------------------------------

<PAGE>

                         REGISTRATION RIGHTS AGREEMENT


     This Registration Rights Agreement is entered into as of December 22, 1995
by and among Sequenom, Inc., a Delaware corporation (the "Corporation"), and the
purchasers of shares of the Corporation's Series B Convertible Preferred Stock,
par value $.001 per share (the "Series B Preferred Stock"), pursuant to the
Series B Convertible Preferred Stock Purchase Agreement dated as of the date
hereof (the "Purchase Agreement"), including any Additional Investors as defined
in the Purchase Agreement (such purchasers of Series B Preferred Stock being
hereinafter sometimes referred to individually as an "Investor" and collectively
as the "Investors").

     WHEREAS, the Corporation has previously issued to certain of the Investors
certain shares of the Corporation's Series A Convertible Preferred Stock, $.001
par value per share (the "Series A Preferred Stock" and, together with the
Series B Preferred Stock, the "Preferred Stock");

     WHEREAS, the Corporation now wishes to sell to the Investors certain shares
of its Series B Preferred Stock;

     WHEREAS, the Preferred Stock is convertible into shares of the
Corporation's Common Stock, par value $.001 per share ("Common Stock"); and

     WHEREAS, as a condition to entering into the Purchase Agreement, the
Investors have required that the Corporation execute this Agreement to provide
the Investors rights to register the shares of Common Stock into which their
Preferred Stock is convertible;

     NOW, THEREFORE, in consideration of the premises and the mutual agreements
hereinafter set forth, the parties hereto agree as follows:

     1.   Definitions.  As used in this Agreement, the following terms shall
          -----------
have the following meanings:

          (a) The term "Act" means the Securities Act of 1933, as amended;

          (b) The term "Holder" means any Investor and any other person or
entity holding Registrable Securities to whom the registration rights granted in
this Agreement have been transferred pursuant to Section 14 hereof;

     (c) The terms "register," "registered," and "registration" refer to a
registration effected by preparing and filing a registration statement in
compliance with the Act and the declaration or ordering of effectiveness of such
registration statement; and

     (d) The term "Registrable Securities" means (1) the Common Stock issuable
upon conversion of the Preferred Stock, (2) Common Stock purchased by an
Investor pursuant to Section 8.1 of the Purchase Agreement (or Common Stock for
or into which New Securities
<PAGE>

(as therein defined) purchased by the Investor pursuant to such Section 8.1 may
be exercised or converted) or pursuant to the Stock Restriction Agreement
referred to in Section 6.6 of the Purchase Agreement, and (3) any Common Stock
of the Corporation issued as a dividend or other distribution with respect to,
or in exchange or in replacement of, such Preferred Stock or Common Stock.

     In addition, for purposes of all calculations and notices under this
Agreement, and all other provisions of this Agreement where the context permits,
the term "Registrable Securities" shall include securities issuable upon
conversion of the Preferred Stock, a holder of the Preferred Stock shall be
deemed the Holder of such securities and such securities shall be deemed
outstanding Registrable Securities hereunder.  Notwithstanding the foregoing,
nothing in this Agreement shall require the Corporation actually to register any
shares of the Preferred Stock.

     2.   Request for Registration.  If at any time after the earlier of (i) the
          ------------------------
first underwritten public offering of securities for the account of the
Corporation, and (ii) the date three (3) years from the date hereof, the
Corporation shall receive a written request (specifying that it is being made
pursuant to this Section 2) from the Holder or Holders at least fifty percent
(50%) of the then outstanding Registrable Securities that the Corporation file a
registration statement under the Act, or a similar document pursuant to any
other statute then in effect corresponding to the Act, covering the registration
of at least the lesser of (i) at least twenty-five percent (25%) of the then
outstanding Registrable Securities and (ii) Registrable Securities the expected
price to the public of which equals or exceeds $10,000,000, then the Corporation
shall promptly notify all other Holders of such request and shall use its best
efforts to cause all Registrable Securities that Holders have requested be
registered to be registered under the Act.

     Notwithstanding the foregoing, (a) the Corporation shall not be obligated
to effect a registration pursuant to this Section 2 during the period starting
with the date sixty (60) days prior to the Corporation's estimated date of
filing of, and ending on a date six (6) months following the effective date of,
a registration statement pertaining to an underwritten public offering of
securities for the account of the Corporation, provided that the Corporation is
actively employing in good faith its best efforts to cause such registration
statement to become effective and that the Corporation's estimate of the date of
filing such registration statement is made in good faith; (b) the Corporation
shall not be obligated to effect a registration pursuant to this Section 2
within six (6) months after the effective-date of a prior registration under
such Section; (c) if the Corporation shall furnish to the Holders a certificate
signed by the President of the Corporation stating that in the good faith
judgment of the Board of Directors it would be seriously detrimental to the
Corporation or its shareholders for a registration statement to be filed in the
near future, then the Corporation's obligation to use its best efforts to file a
registration statement shall be deferred for a period not to exceed three (3)
months; and (d) the Corporation may postpone a registration pursuant to this
election for such period of time as may be required to permit the use of regular
audited year-end financial statements with supplemental short period figures for
a period not exceeding six (6) months unless the Holders agree to bear the costs
of any special audit.

                                      -2-
<PAGE>

     The Corporation shall not be obligated to effect more than two (2)
registrations pursuant to this Section 2.  Any request for registration under
this Section 2 must be for a firm commitment underwritten public offering to be
managed by an underwriter or underwriters of recognized national standing
reasonably acceptable to the Corporation.

     3.   Corporation Registration.  Subject to Section 8 of this Agreement, if
          ------------------------
at any time the Corporation proposes to register any of its Common Stock under
the Act in connection with the public offering of such securities for its own
account or for the accounts of other shareholders, solely for cash on a form
that would also permit the registration of the Registrable Securities, the
Corporation shall, each such time, promptly give each Holder written notice of
such determination. Upon the written request of any Holder given within thirty
(30) days after mailing of any such notice by the Corporation, the Corporation
shall, subject to the limitations set forth in Section 8(a), use its best
efforts to cause to be registered under the Act all of the Registrable
Securities that each such Holder has requested be registered.

     4.   Obligations of the Corporation.  Whenever required under
          ------------------------------
Section 2, 3, or 11 to use its best efforts to effect the registration of any
Registrable Securities, the Corporation shall, as expeditiously as reasonably
possible:

     (a)  Prepare and file with the Securities and Exchange Commission ("SEC") a
registration statement with respect to such Registrable Securities and use its
best efforts to cause such registration statement to become and remain
effective; provided, however, that in connection with any proposed registration
intended to permit an offering of any securities from time to time (i.e., a so-
called "shelf registration the Corporation shall in no event be obligated to
cause any such registration to remain effective for more than one hundred eighty
(180) days.

     (b)  Prepare and file with the SEC such amendments and supplements to such
registration statement and the prospectus used in connection with such
registration statement as may be necessary to comply with the provisions of the
Act with respect to the disposition of all securities covered by such
registration statement.

     (c)  Furnish to the Holders such numbers of copies of a prospectus,
including a preliminary prospectus, in conformity with the requirements of the
Act, and such other documents as they may reasonably request in order to
facilitate the disposition of Registrable Securities owned by them.

     (d)  Use its best efforts to register and qualify the securities covered by
such registration statement under such other securities or Blue Sky laws of such
jurisdictions as shall be reasonably appropriate for the distribution of the
securities covered by the registration statement, provided that the Corporation
shall not be required in connection therewith or as a condition thereto to
qualify to do business or to file a general consent to service of process in any
such states or jurisdictions, and further provided that (anything in this
Agreement to the contrary notwithstanding with respect to the bearing of
expenses) if any jurisdiction in which the securities shall be qualified shall
require that expenses incurred in connection with the qualification of the
securities in that jurisdiction be borne by selling shareholders, then such

                                      -3-
<PAGE>

expenses shall be payable by selling shareholders pro rata, to the extent
required by such jurisdiction.

     (e)  Provide a transfer agent for the Common Stock no later than the
effective date of the first registration of any Registrable Securities.

     5.   Furnish Information.  It shall be a condition precedent to the
          -------------------
obligations of the Corporation to take any action pursuant to this Agreement
that the Holders shall furnish to the Corporation such information regarding
them, the Registrable Securities held by them, and the intended method of
disposition of such securities as the Corporation shall reasonably request and
as shall be required in connection with the action to be taken by the
Corporation.

     6.   Expenses of Demand Registration.  All expenses incurred in connection
          -------------------------------
with registrations pursuant to Section 2 (excluding underwriters, discounts and
commissions), including, without limitation, all registration and qualification
fees, printers, and accounting fees, fees and disbursements of counsel for the
Corporation, and the reasonable fees and disbursements of one special counsel
for the selling Holders, shall be borne by the corporation.

     7.   Corporation Registration Expenses.  All expenses (excluding
          ---------------------------------
underwriters, discounts and commissions) incurred in connection with a
registration pursuant to Section 3 (other than a registration on Form S-3 filed
pursuant to Section 11), including, without limitation, any additional
registration and qualification fees and any additional fees and disbursements of
counsel to the Corporation that result from the inclusion of securities held by
the Holders in such registration and the reasonable fees and disbursements of
one special counsel for the selling stockholders, shall be borne by the
Corporation; provided, however, that if the registration is of exclusively a
secondary offering, the holders shall bear their proportionate share of the
expenses incurred in connection with any registration (provided all shareholders
registering shares thereunder bear their proportionate share of expenses),
except expenses which the Corporation would have incurred whether or not the
securities held by the Holders were included in such registration (including,
without limitation, the expense of preparing normal audited or unaudited
financial statements).

     8.   Underwriting Requirements.
          -------------------------

     (a)  In connection with any offering involving an underwriting of shares
being issued by the Corporation, the Corporation shall not be required under
Section 3 to include any of the Holders' Registrable Securities in such
underwriting unless they accept the terms of the underwriting as agreed upon
between the Corporation and the underwriters selected by it, and then only in
such quantity as will not, in the reasonable opinion of the underwriters,
jeopardize the success of the offering by the Corporation.  If the total amount
of securities that all Holders request to be included in an underwritten
offering exceeds the amount of securities that the underwriters reasonably
believe compatible with the success of the offering, the Corporation shall only
be required to include in the offering so many of the securities of the selling
Holders as the underwriters reasonably believe will not jeopardize the success
of the offering (the securities so included to be apportioned pro rata among the
selling Holders according to the total amount of securities owned by said
selling Holders, or in such other proportions as shall

                                      -4-
<PAGE>

mutually be agreed to by such selling Holders), provided that in the case of an
offering involving shares being issued by the Corporation, no such reduction
shall be made with respect to any securities offered by the Corporation for its
own account, and provided further that no securities of any shareholder who is
not a Holder shall be included in such offering, other than securities of
shareholders who have initiated such registration pursuant to the exercise of
contractual rights to do so, unless all securities which the Holders have
requested to be included are included on a pro rata basis with the securities of
any other shareholders who have a contractual right to include their securities
in such offering.

     (b)  With respect to any underwriting of shares to be registered under
Section 2, or an underwriting of shares to be registered under Section 11 if the
Holders of a majority of the then outstanding Registrable Securities have
requested registration thereunder, such Holders shall have the right to
designate the managing underwriter or underwriters, subject to the consent of
the Corporation.  In all other circumstances under such Sections and in
connection with registrations under Section 3, the Corporation shall have the
right to designate the managing underwriter or underwriters; subject to the
consent of the Holders of a majority of the Registrable Securities participating
in the underwriting.  In any such case, such consent shall not be unreasonably
withheld or delayed.

     9.   Delay of Registration.  No Holder shall have any right to take any
          ---------------------
action to restrain, enjoin, or otherwise delay any registration as the result of
any controversy that might arise with respect to the interpretation or
implementation of this Agreement.

     10.  Indemnification.  In the event any Registrable securities are included
          ---------------
in a registration statement under this Agreement:

     (a)  To the extent permitted by law, the Corporation will indemnify and
hold harmless each Holder requesting or joining in a registration, any
underwriter (as defined in the Act) for it, and each person, if any, who
controls such Holder or underwriter within the meaning of the Act, against any
losses, claims, damages or liabilities, joint or several, to which they may
become subject under the Act or otherwise, insofar as such losses, claims,
damages or liabilities (or actions in respect thereof) arise out of or are based
on any untrue or alleged untrue statement of any material fact contained in such
registration statement, including, without limitation, any preliminary
prospectus or final prospectus contained therein or any amendments or
supplements thereto, or arise out of or are based upon the omission or alleged
omission to state therein a material fact required to be stated therein, or
necessary to make the statements therein not misleading or arise out of any
violation by the Corporation of any rule or regulation promulgated under the Act
applicable to the Corporation and relating to action or inaction required of the
Corporation in connection with any such registration; and will reimburse each
such Holder, such underwriter, or controlling person for any legal or other
expenses reasonably incurred by them in connection with investigating or
defending any such loss, claim, damage, liability, or action, provided, however,
that the indemnity agreement contained in this Section 10(a) shall not apply to
amounts paid in settlement of any such loss, claim, damage, liability or action
if such settlement is effected without the consent of the corporation (which
consent shall not be unreasonably withheld or delayed) nor shall the Corporation
be liable in any such case for any such loss, claim, damage, liability or action
to the extent that it arises out of or is based upon an

                                      -5-
<PAGE>

untrue statement or alleged untrue statement or omission or alleged omission
made in connection with such registration statement, preliminary prospectus,
final prospectus, or amendments or supplements thereto, in reliance upon and in
conformity with written information furnished expressly for use in connection
with such registration by any such Holder, underwriter or controlling person.

     (b)  To the extent permitted by law, each Holder requesting or joining in a
registration will indemnify and hold harmless the Corporation, each of its
directors, each of its officers who has signed the registration statement, each
person, if any, who controls the Corporation within the meaning of the Act, and
any underwriter for the Corporation (within the meaning of the Act) against any
losses, claims, damages or liabilities to which the corporation or any such
director, officer, controlling person or underwriter may become subject, under
the Act or otherwise, insofar as such losses, claims, damages or liabilities (or
actions in respect thereto) arise out of or are based upon any untrue statement
or alleged untrue statement of any material fact contained in such registration
statement, including any preliminary prospectus or final prospectus contained
therein or any amendments or supplements thereto, or arise out of or are based
upon the omission or alleged omission to state therein a material fact required
to be stated therein or necessary to make the statements therein not misleading,
in each case to the extent, but only to the extent, that such untrue statement
or alleged untrue statement or omission or alleged omission was made in such
registration statement, preliminary prospectus or final prospectus, or
amendments or supplements thereto, in reliance upon and in conformity with
written information furnished by such Holder expressly for use in connection
with such registration; and will reimburse the Corporation or any such director,
officer, controlling person or underwriter for any legal or other expenses
reasonably incurred by them in connection with investigating or defending any
such loss, claim, damage, liability or action; provided, however, that the
indemnity agreement contained in this Section 10(b) shall not apply to amounts
paid in settlement of any such loss, claim, damage, liability or action if such
settlement is effected without the consent of such Holder (which consent shall
not be unreasonably withheld) and provided further that no Holder shall have any
liability under this Section 10(b) in excess of the net proceeds actually
received by such Holder in the relevant public offering.

     (c)  Promptly after receipt by an indemnified party under this Section 10
of notice of the commencement of any action, such indemnified party will, if a
claim in respect thereof is to be made against any indemnifying party under this
Section 10, notify the indemnifying party in writing of the commencement thereof
and the indemnifying party shall have the right to participate in, and, to the
extent the indemnifying party so desires, jointly with any other indemnifying
party similarly noticed, to assume the defense thereof with counsel mutually
satisfactory to the parties. The failure to notify an indemnifying party
promptly, of the commencement of any such action, if prejudicial to his ability
to defend such action, shall relieve such indemnifying party of any liability to
the indemnified party under this Section 10, but the omission so to notify the
indemnifying party will not relieve him of any liability that he may have to any
indemnified party otherwise than under this Section 10.

                                      -6-
<PAGE>

     11.  Registrations on Form S-3.
          -------------------------

     (a)  If (i) the Corporation shall receive a written request (specifying
that it is being made pursuant to this Section 11) from the Holder or Holders of
at least twenty-five percent (25%) of the then outstanding Registrable
Securities that the Corporation file a registration statement on Form S-3 (or
any successor form to Form S-3 regardless of its designation) for a public
offering of shares of the Registrable Securities the reasonably anticipated
aggregate price to the public of which would exceed Two Million Dollars
($2,000,000), and (ii) the corporation is a registrant entitled to use Form S-3
to register such shares, then the Corporation shall use its best efforts to
cause such shares to be registered on Form S-3 (or any successor form to Form
S-3).

     (b)  All expenses (excluding underwriters' discounts and commissions)
incurred in connection with the first two registrations requested pursuant to
Section 11(a), including, without limitation, all registration, qualification,
printing, and accounting fees, and fees and disbursements of one special counsel
to the selling Holder or Holders and counsel to the Corporation, shall be borne
by the Corporation.  All such expenses for registrations pursuant to Section
11(a) after the first two such registrations shall be borne by the Corporation,
except that the selling Holders shall pay all fees of their legal counsel, if
any, in connection therewith.

     (c)  Holders' rights to registration under this Section 11 are in addition
to, and not in lieu of, their rights to registration under Sections 2 and 3 of
this Agreement.

     12.  Reports Under Securities Exchange Act of 1934.  With a view to making
          ---------------------------------------------
available to the Holders the benefits of Rule 144 promulgated under the Act and
any other rule or regulation of the SEC that may at any time permit a Holder to
sell securities of the Corporation to the public without registration, the
corporation agrees to use its best efforts to:

     (a)  make and keep public information available, as those terms are
understood and defined in Rule 144, at all times subsequent to ninety (90) days
after the effective date of the first registration statement covering an
underwritten public offering filed by the Corporation;

     (b)  file with the SEC in a timely manner all reports and other documents
required of the Corporation under the Act and the Securities Exchange Act of
1934, as amended (the "1934 Act"); and

     (c)  furnish to any Holder forthwith upon request a written statement by
the Corporation that it has complied with the reporting requirements of Rule 144
(at any time after ninety (90) days after the effective date of said first
registration statement filed by the Corporation), and of the Act and the 1934
Act (at any time after it has become subject to such reporting requirements), a
copy of the most recent annual or quarterly report of the Corporation, and such
other reports and documents so filed by the Corporation as may be reasonably
requested in availing any such holder to take advantage of any rule or
regulation of the SEC permitting the selling of any such securities without
registration.

                                      -7-
<PAGE>

     13.  Limitations in Connection with Future Grants of Registration Rights.
          -------------------------------------------------------------------
Without the prior written consent of the Holder or Holders of a majority of the
then outstanding Registrable Securities issued or issuable upon conversion of
the Series B Preferred Stock, the Corporation shall not grant rights to cause
the Corporation to register any of its securities to any person or entity.

     14.  Transfer of Registration Rights.  The registration rights of any
          -------------------------------
Investor (and of any permitted transferee of any Investor or its permitted
transferees) under this Agreement with respect to any shares of Registrable
Securities may be transferred to any Affiliate of such Investor or such
permitted transferee, or to any transferee who acquires (otherwise than in a
registered public offering) at least five percent (5%) of the Registrable
Securities held or acquired as of the date hereof by such Investor, provided,
however, that the Corporation is given written notice by the Holder at the time
of such transfer stating the name and address of the transferee and identifying
the securities with respect to which the rights under this Agreement are being
assigned. For such purpose, an "Affiliate" of any Investor (or any such
transferee) means any partner of such Investor (or transferee) if it is a
partnership, or any person or entity that, directly or indirectly, through one
or more intermediaries, controls or is controlled by, or is under common control
with, such Investor or transferee.

     15.  Mergers, Etc.  The Corporation shall not, directly or indirectly,
          ------------
enter into any merger, consolidation or reorganization in which the Corporation
shall not be the surviving corporation unless the proposed surviving corporation
shall, prior to such merger, consolidation or reorganization, agree in writing
to assume the obligations of the Corporation under this Agreement, and for that
purpose references hereunder to "Registrable Securities" shall be deemed to be
references to the securities which the Holders would be entitled to receive in
exchange for Registrable Securities under any such merger, consolidation or
reorganization; provided, however, that the provisions of this Agreement shall
not apply in the event of any merger, consolidation or reorganization in which
the Corporation is not the surviving corporation if the Holders of Registrable
Securities are entitled to receive in exchange therefor (i) cash, or (ii)
securities of the acquiring corporation which may be immediately sold to the
public without registration under the Act.

     16.  Accession.  Any Additional Investors as defined in the Purchase
          ---------
Agreement shall automatically become an Investor hereunder by delivering to the
Corporation a written instrument in the form of Exhibit A hereto, by which such
                                                ---------
Additional Investor agrees to be bound by the obligations imposed under this
Agreement, whereupon such Additional Investor shall automatically become a party
to this Agreement and shall thereupon be deemed an "Investor" for all purposes
of this Agreement.

     17.  Notices.  All notices, requests, consents and other communications
          -------
hereunder to any party shall be deemed to be sufficient if contained in a
written instrument delivered in person or duly sent by first class mail, postage
prepaid, or by any internationally recognized courier service, addressed to such
party at the address set forth below or such other address as may hereafter be
designated in writing by the addressee to the addressor listing all parties:

                                      -8-
<PAGE>

          (i)  if to the Corporation, to:

               Sequenom, Inc.
               c/o TVM Techno Venture Management
               101 Arch Street
               Suite 1950
               Boston, MA 02110
               Attention: President

               with a copy to:

               David R. Pierson, Esq.
               Foley, Hoag & Eliot
               One Post office Square
               Boston, Massachusetts 02109

          (ii) if to the Investors (or their transferees), to their respective
               last known address or their respective address, if any, appearing
               in the books of the Corporation.

     18.  Miscellaneous.
          -------------

     (a)  This Agreement states the entire agreement of the parties concerning
the subject matter hereof, and supersedes all prior agreements, written or oral,
between or among them concerning such subject matter.

     (b)  This Agreement may be amended, and compliance with any provision of
this Agreement may be omitted or waived, only by the written agreement of the
Corporation and the Holders of at least eighty-five percent (85%) in voting
power of the then outstanding Registrable Securities issued or issuable upon
conversion of the Series B Preferred Stock to be bound thereby.

     (c)  This Agreement shall be governed by, and construed and enforced in
accordance with, the substantive laws of The Commonwealth of Massachusetts,
without regard to its principles of conflicts of laws.

     (d)  This Agreement may be executed in any number of counterparts, each
such counterpart shall be deemed to be an original instrument, and all such
counterparts together shall constitute but one agreement. Any such counterpart
may contain one or more signature pages.

                                      -9-
<PAGE>

     IN WITNESS WHEREOF, the parties have executed this Agreement as a contract
under seal as of the date first written above.

                                   SEQUENOM, INC.

                                   By:  ________________________________________

                                     -10-
<PAGE>

                                SEQUENOM, INC.

                         Registration Rights Agreement

                            Investor Signature Page
                            -----------------------

     By executing this page in the space provided, the undersigned hereby agrees
(i) that it is an "Investor" as defined in the Registration Rights Agreement
dated as of __________ __, 1995, by and among Sequenom, Inc. and the parties
named therein, (ii) that it is a party to the Registration Rights Agreement for
all purposes and (iii) that it is bound by all terms and conditions of the
Registration Rights Agreement.

     EXECUTED this __ day of __________, 1995.


                                        ________________________________________
                                        (print name)

                                        By:    _________________________________

                                        Title: _________________________________

                                        Address: _______________________________
<PAGE>

                                 EXHIBIT 4.16B
                                 -------------

                           Form of Voting Agreement
                           ------------------------

<PAGE>

                                VOTING AGREEMENT

     Agreement made as of December 22, 1995 by and among Sequenom, Inc., a
Delaware corporation (the "Corporation"); Hubert Koster, Nola E. Masterson and
Robert E. Patterson (the "Founders"); TVM Techno Venture Enterprises No. II
Limited Partnership, TVM Intertech Limited Partnership TVM Zweite Beteiligung-
U.S. Limited Partnership, TVM Eurotech Limited Partnership, TVM Techno Venture
Investors No. 1 Limited Partnership and *** (the "Original Investors"); the
purchasers of shares of the Corporation's Series B Convertible Preferred Stock,
$.001 par value per share ("Series B Preferred Stock"), pursuant to the Series B
Convertible Preferred Stock Purchase Agreement dated as of the date hereof (the
"Purchase Agreement"), including Boston University Nominee Partnership ("BU")
and any Additional Investors as defined in the Purchase Agreement (all such
purchasers of Series B Preferred Stock under the Purchase Agreement being
referred to as the "Investors," and all such Founders, Original Investors and
Investors being referred to as the "Stockholders").

                                   AGREEMENT
                                   ---------

     In consideration of the mutual covenants herein contained, the parties
hereto agree as follows:

     1.   Board of Directors.  The Stockholders agree to vote all shares of the
          ------------------
Corporation's Common Stock, $.001 par value per share ("Common Stock"), Series A
Convertible Preferred Stock, $.001 par value per share ("Series A Preferred
Stock"), Series B Preferred Stock and any other class of voting security of the
Corporation (the "Shares") now or hereafter owned or controlled by them, and
otherwise to use their respective best efforts as stockholders of the
Corporation, to set the number of directors of the Corporation at seven and to
elect as directors, on the date of this Agreement and in any subsequent election
of directors of the Corporation: the Chief Executive Officer of the Corporation,
who shall initially be Randall R. Lunn; one person designated by the Founders,
who shall initially be Hubert Koster; one person designated by the Original
Investors, who shall initially be Helmut Schuhsler; one person designated by BU,
who shall initially be William Golden; one person designated by the Investors,
who shall be designated and elected after the date of this Agreement; and two
persons who are not employees of the Corporation, who have experience in the
Corporation's industry and who are reasonably acceptable to a majority of the
other directors, and who shall initially be Nola E. Masterson and Ernst Gunter
Afting.

     Any party or parties making director designations (a "Designating Party")
shall furnish written notice to the other parties at least 10 days prior to any
election of directors of their director-designee or director-designees.  In the
absence of such notice, the director-designee or director-designees of such
Designating Party then serving and previously designated shall be reelected if
still eligible to, serve as provided herein.  No party hereto shall vote to
remove any member of the Board of Directors designated in accordance with the
aforesaid procedure unless the Designating Party who designated such director so
votes, and if such Designating party so votes then the other parties shall
likewise so vote.

     Any vacancy on the Board of Directors created by the resignation, removal,
incapacity, or death of any person designated under this Section 1 shall be
filled by another person designated

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.


<PAGE>

by the original Designating Party. The Stockholders shall vote their respective
Shares in accordance with such new designation, and any such vacancy shall not
be filled in the absence of a new designation by the original Designating Party.

     This Section 1 shall terminate and be of no further force and effect upon
the closing of a firm commitment underwritten public offering of Common Stock of
the Corporation pursuant to an effective registration statement under the
Securities Act of 1933, as amended, in which the aggregate gross proceeds to the
Corporation from such offering are not less than $10,000,000 and the offering
price per share is not less than $4.50, appropriately adjusted to take account
of any stock split, stock dividend, combination of shares or similar event.

     In the event that any Designating Party (or its or their respective
partners, stockholders and affiliates) owns, in the aggregate, fewer than
200,000 shares of the Corporation's Common Stock, subject to adjustment for
stock splits, stock dividends, combinations of shares and similar events, such
Designating Party's right to make designations under this Section 1 shall
terminate, and the obligation of the other parties under this Section 1 to vote
for any members of the Board of Directors designated by such Designating Party
shall terminate, but all other obligations of all parties hereunder shall
continue unless otherwise terminated.  For purposes of this paragraph, in
determining the number of shares of Common Stock owned by a Designating Party,
ownership by such Designating Party of shares of Series A Preferred Stock and
Series B Preferred Stock shall be deemed to be ownership by it of that number of
shares of Common Stock into which such shares of Series B Preferred Stock are
convertible.

     In the event that any group of Stockholders constituting a Designating
Party cannot agree upon a director-designee, the identity of the director-
designee of such Designating Party shall be determined by a plurality in voting
power of the outstanding capital stock of the Corporation held by such
Stockholders.

     In the event that BU shall fail to participate in any future equity
financing for the Corporation for its full pro rata share of the portion of such
financing purchased by the then-existing institutional investors in the
Corporation, (i) BU's right to make designations under this Section 1 shall-
terminate, and the obligation of the other parties under this Section 1 to vote
for any member of the Board of Directors designated by BU shall terminate, but
all other rights and obligations of all parties hereunder, including the right
of BU to participate as an Investor in the designation of any person to the
Board of Directors, shall continue unless otherwise terminated; and (ii)
thereafter the Investors shall have the right to designate two persons for
election to the Board of Directors.

     2.   Director Indemnification.  In the event that any director contemplated
          ------------------------
by this Agreement shall be made or threatened to be made a party to any action,
suit or proceeding with respect to which he may be entitled to indemnification
by the Corporation pursuant to its Certificate of Incorporation, By-Laws or
otherwise, he shall be entitled to be represented in such action, suit or
proceeding by counsel of his choice and the expenses of such representation
shall be reimbursed by the Corporation to the extent provided in or authorized
by said Certificate of Incorporation or other provision and permitted by
applicable law.

                                      -2-
<PAGE>

     The Corporation and the Stockholders agree not to take any action to amend
any provision of the Certificate of Incorporation or By-Laws of the Corporation
relating to indemnification of directors, as presently in effect, without the
prior written consent of a majority in voting power of the Investors.

     3.   Accession.  Any Additional Investors as defined in the Purchase
          ---------
Agreement shall automatically become an Investor hereunder by delivering to the
Corporation a written instrument in the form of Exhibit A hereto, by which such
                                                ---------
Additional Investor agrees to be bound by the obligations imposed under this
Agreement, whereupon such Additional Investor shall automatically become a party
to this Agreement and shall thereupon be deemed an "Investor" and a
"Stockholder" for all purposes of this Agreement.

          4.   Notices.  All notices, requests, consents and other
               -------
communications hereunder to any party shall be deemed to be sufficient if
contained in a written instrument delivered in person or duly sent by first
class mail, postage prepaid, or by any internationally recognized express
courier service, addressed to such party at the address set forth below or such
other address as may hereafter be designated in writing by the addressee to the
addressor listing all parties:

          (i)  if to the Corporation, to:

               Sequenom, Inc.
               c/o TVM Techno Venture Management
               101 Arch Street
               Suite 1950
               Boston, MA 02110
               Attention: President

               with a copy to:

               David R. Pierson, Esq.
               Foley, Hoag & Eliot
               One Post office Square
               Boston, Massachusetts 02109

          (ii) if to the Stockholders, to their respective last known address or
               their respective address, if any, appearing in the books of the
               Corporation.

     5.   Assignment; Binding Effect.  No Designating Party may assign its or
          --------------------------
their rights hereunder. Subject to termination or partial termination as
provided in Section 1, this Agreement shall be binding on the parties hereto and
their respective legal representatives, successors and permitted assigns and on
the transferees of any Shares now owned or hereafter acquired by them.

     6.   Entire Agreement; Amendment and Waiver.  This Agreement contains the
          --------------------------------------
sole and entire understanding of the parties with respect to its subject matter
and supersedes all prior negotiations, commitments, agreements and
understandings heretofore had among any of them with respect thereto. Without
limiting the generality of the foregoing, this Agreement supersedes

                                      -3-
<PAGE>

and replaces the Voting Agreement among the Founders and the Original Investors
dated May 26, 1994, which shall no longer have any force or effect. This
Agreement may not be changed or terminated or any performance or condition
waived, in whole or in part, except by the written agreement of the Corporation
and Stockholders or transferees of their rights hereunder holding two-thirds in
voting power of the Shares held by the Founders, two-thirds in voting power of
the Shares held by the Original Investors, eighty-five percent (85%) in voting
power of the Shares held by the Investors, and two-thirds in voting power of the
Shares held by the Stockholders or such transferees. A waiver on one occasion
shall not constitute a waiver on any further occasion.

     7.   Counterparts.  This Agreement may be executed in more than one
          ------------
counterpart, each of which shall be deemed to be an original and which,
together, shall constitute one and the same instrument. Any such counterpart may
contain one or more signature pages.

     8.   Applicable Law.  This Agreement shall be governed by, and construed
          --------------
and enforced in accordance with, the substantive laws of The Commonwealth of
Massachusetts, without regard to its principles of conflicts of laws.

     9.   Legend.  Each certificate for Shares shall bear a legend stating in
          ------
substance as follows, and each of the Stockholders shall cause its certificates
to be so legended promptly after the execution and delivery of this Agreement:

     The shares of stock represented by this certificate are subject to the
     terms and provisions of a Voting Agreement dated December 22, 1995 among
     the Corporation and certain stockholders of the Corporation.  The
     Corporation will furnish a copy of the Voting Agreement to the holder
     hereof upon written request and without charge.

                                    *  *  *

                                      -4-
<PAGE>

          IN WITNESS WHEREOF, the parties have executed this Agreement as a
contract under seal as of the date-first written above.


                              SEQUENOM, INC.



                              By:___________________________________



                              FOUNDERS:


                              ______________________________________
                              Hubert Koster


                              ______________________________________
                              Nola E. Masterson


                              ______________________________________
                              Robert E. Patterson

                              ORIGINAL INVESTORS:


                              TVM Techno Venture Enterprises
                              No. II Limited Partnership


                              By:___________________________________

                              TVM Intertech Limited Partnership


                              By:___________________________________

                              TVM Zweite  Beteiligung-U.S.
                              Limited Partnership


                              By:___________________________________
<PAGE>

                              TVM Eurotech Limited Partnership


                              By:___________________________________


                              TVM Techno Venture Investors
                              No. 1 Limited Partnership


                              By:___________________________________
                                              ***

/***/ Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.





<PAGE>

                                 SEQUENOM, INC.

                          Stock Restriction Agreement

                            Investor Signature Page
                            -----------------------


     By executing this page in the space provided, the undersigned hereby agrees
(i) that it is an "Investor" as defined in the Stock Restriction Agreement dated
as of December 22, 1995, by and among Sequenom, Inc. and the parties named
therein, (ii) that it is a party to the Stock Restriction Agreement for all
purposes and (iii) that it is bound by all terms and conditions of the Stock
Restriction Agreement.

     EXECUTED this ___ day of ___________, 1995.


                              ______________________________________
                              (print name)


                              By:   ________________________________

                              Title:  ______________________________

                              Address:  ____________________________
<PAGE>

                                                                       Exhibit A
                                                                       ---------

                                 SEQUENOM, INC.

                                Voting Agreement

                       Additional Investor Signature Page
                       ----------------------------------


          By executing this page in the space provided, the undersigned hereby
agrees (i) that it is an "Additional Investor", as defined in the Series B
Convertible Preferred Stock Purchase Agreement dated as of ____________ ___,
1995, and an "Investor" and a "Stockholder" as defined in the Voting Agreement
dated as of ____________ ___, 1995, each by and among Sequenom, Inc. and the
parties named therein, (ii) that it is a party to the Voting Agreement for all
purposes and (iii) that it is bound by all terms and conditions of the Voting
Agreement.


          EXECUTED this _____ day of _____________, 1995.



                              ______________________________________
                              (print name)


                              By:___________________________________

                              Title:________________________________

                              Address:______________________________
<PAGE>

                                  EXHIBIT 4.19
                                  ------------

                              Related Transactions
                              --------------------


          Loan from the Corporation to Nola Masterson, a director, in the
outstanding principal amount of $8,800.
<PAGE>

                                  EXHIBIT 4.20
                                  ------------

                             Governmental Consents
                             ---------------------

None.
<PAGE>

                                 EXHIBIT 4.23
                                 ------------

                      Commitments from German Government
                      ----------------------------------


See attachment hereto.
<PAGE>

Sequenom, Inc. (the "Inc.") and Sequenom Instruments GmbH (the "GmbH")

Description of agreements with Technologie-Beteiligungs-Gesellschaft m.b.H. der
Deutschen Ausgleichsbank ("TBG")

1.   The May 1995 "BJTU" Agreement
     -----------------------------

The TBG has provided DM 1 million silent partnership financing to the GmbH,
which matches DM 1 million of capital invested in the GmbH by the Inc. The terms
of the silent partnership arrangement are as follows:

Interest rate of 6% on the principal amount of the silent partnership loan.

Interest payable beginning June 30, 1997.

Additional compensation as follows:
     9% of any annual profits, beginning with fiscal year 1997, if the profits
     exceed DM 100,000, up to a maximum compensation amount of 6% of the silent
     partnership loan.

Principal payment due on December 31, 2005

This agreement has no "downside protection" which is contained in the 1995
agreement.

2.   The December 1995 "BJTU" Agreement
     ----------------------------------

The TBG has committed to provide up to DM 3 million silent partnership financing
to the GmbH, which will match up to DM 3 million of capital invested in the GmbH
by the Inc.  To date the TBG has matched DM 250,000 of capital which has been
invested by the Inc.

The terms of the silent partnership arrangement are as follows:

Interest rate of 6% on the principal amount of the silent partnership loan.

Interest payable beginning June 30, 1997.

Additional compensation as follows:
     9% of any annual profits, beginning with fiscal year 1997 if the profits
     exceed DM 100,000, up to a maximum compensation amount of 6% of the silent
     partnership loan.

Principal payment due on December 31, 2005

This agreement also contains a "50% downside protection" for the investors in
the Inc. as follows: Under certain circumstances, if the Inc. exercises its "put
option" to the TBG of its equity interest in the GmbH, the TBG will pay to the
Inc. 50% of the amount of the silent partnership.
<PAGE>

Description of the grant programs for which Sequenom Instruments GmbH has
received approvals:

1.   Grant from the "Biotechnology 2000" grant scheme from the Ministry of
     Research and Technology ("BMBF"):

     The BMBF has approved a grant (which is a non-repayable contribution) in
     the amount of DM 2.2 million based on the application for the financing of
     a total research and development project of DM 4.4 million. The grant
     coverage is therefore 50% of total estimated project cost. The company will
     call the money quarterly in arrears based on actual cost attributable to
     the project. The project started on September 1, 1995 and has a duration of
     three years.

2.   Grant from Freie und Hansestadt Hamburg, (City of Hamburg):

     The City of Hamburg has approved a grant of DM 800,000 based on a list of
     equipment for Sequenom's laboratory to be purchased after September 1,
     1995. Total expected cash outflows for the equipment purchases is DM 1.6.
     million. Grant coverage is also 50% of estimated cost.

Both grants do not have to be repaid.
<PAGE>

                                  EXHIBIT 6.5
                                  -----------

                   Form of opinion of Counsel to Corporation
                   -----------------------------------------
<PAGE>

                      [LETTERHEAD OF FOLEY, HOAG & ELIOT]

                               December 22, 1995


To the Persons listed in the Schedule
of Investors to the Series B
Convertible Preferred Stock Purchase
Agreement dated as of December 22, 1995

Gentlemen:

     We are counsel to Sequenom, Inc., a Delaware corporation (the
"Corporation").  This opinion is rendered to you pursuant to Section 6.5 of the
Series B Convertible Preferred Stock Purchase Agreement (including the exhibits
thereto, the "Agreement") dated as of December 22, 1995, among the Corporation
and each of you relating to the issuance and sale by the Corporation to you of
2,333,333 shares (the "Initial Shares") of its Series B Convertible Preferred
Stock, par value $.001 per share (the "Transaction").  Capitalized terms used
herein and not otherwise defined herein shall have the meanings assigned to such
terms in the Agreement.

     In connection with our rendering this opinion, we have reviewed (i) the
Certificate of Incorporation and By-Laws of the Corporation, each as amended to
date; (ii) a certificate issued by the Secretary of State of the State of
Delaware on December 15, 1995, with respect to the due incorporation, legal
existence and good standing of the Corporation in the State of Delaware (the
"Legal Existence Certificate"); (iii) a certificate issued by the Secretary of
State of The Commonwealth of Massachusetts on December 15, 1995, with respect to
the qualification of the Corporation to do business in Massachusetts (the
"Foreign Qualification Certificate"); (iv) counterparts of the Agreement and the
related Registration Rights Agreement of even date herewith (the "Registration
Rights Agreement"); and (v) originals or copies, certified or otherwise,
identified to our satisfaction, of such other documents, certificates,
instruments and corporate records that we considered necessary for the purposes
of this opinion.

     In rendering the opinion expressed herein, we have also examined and have
relied completely as to matters of fact upon the representations and warranties
made by the Corporation and each of you in the Agreement, the Registration
Rights Agreement and the other agreements, instruments and documents delivered
in connection with the Initial Closing; and we have assumed the completeness and
accuracy of all factual matters described in such representations and
warranties.

     We have not, except as specifically noted above, made any independent
review or investigation of facts relating to the Corporation, including but
without limiting the generality of the foregoing, any investigation as to the
existence of any actions, suits or proceedings pending or threatened against the
Corporation or notes, indentures, mortgages, leases, contracts, instruments,
documents, agreements, judgments, injunctions, orders, writs or decrees to which
<PAGE>

To the Persons listed in the Schedule
of Investors to the Series B
Convertible Preferred Stock Purchase
Agreement dated as of December 22, 1995

the Corporation is a party, which are binding upon the Corporation or which
might result in the imposition of any lien or other encumbrance on any asset of
the Corporation.

     We have assumed the authenticity and completeness of all documents
furnished to us as originals, the genuineness of all signatures, the legal
capacity of natural persons, and the conformity to the originals of all
documents furnished to us as copies.

     In rendering the opinions expressed in paragraph 1 below with respect to
the due incorporation, legal existence and good standing of the Corporation in
Delaware and in paragraph 2 below with respect to the qualification of the
Corporation to do business in The Commonwealth of Massachusetts, we have relied
solely on the Legal Existence Certificate and the Foreign Qualification
Certificate, respectively.

     You have not asked us to pass upon your power and authority to enter into
the Agreement or the Registration Rights Agreement.  Accordingly, for the
purposes of this opinion, we have assumed that you have all requisite power and
authority to enter into the Agreement and the Registration Rights Agreement and
to effect the transactions contemplated thereby, and that each of the Agreement
and the Registration Rights Agreement constitutes the valid and legally binding
obligation of all parties thereto other than the Corporation.

     We have made such examination of Massachusetts and federal Law and of the
General Corporation Law of Delaware as we deem necessary for the purposes of
this opinion.  We do not purport to pass herein on the laws of any state or
jurisdiction other than the United States of America and The Commonwealth of
Massachusetts, and as to its General Corporation Law only, the State of
Delaware.

     The opinions herein expressed are qualified to the extent that (i) the
validity or enforceability of any provisions of any agreement or instrument or
of any rights granted thereunder may be subject to or affected by any
bankruptcy, reorganization, insolvency, moratorium or similar law from time to
time in effect and relating to or affecting the rights or remedies of creditors
generally, (ii) the remedy of specific performance or any other equitable remedy
may be unavailable in any jurisdiction or may be withheld as a matter of
judicial discretion; and (iii) a court may apply equitable principles in
construing or enforcing the provisions of any agreement or instrument.

     The phrase "of which we have knowledge" means the actual knowledge of the
lawyer signing this opinion letter and the other lawyers in our office who have
had active involvement in negotiating the Transaction and preparing the
Agreement and the Registration Rights Agreement.

     Based upon and subject to the foregoing, we are of the opinion that:

     1.   The Corporation is a corporation duly incorporated, validly existing
          and in good standing under the laws of the State of Delaware and has
          the requisite corporate power to carry on its business as it is
          currently being conducted.

                                       2
<PAGE>

To the Persons listed in the Schedule
of Investors to the Series B
Convertible Preferred Stock Purchase
Agreement dated as of December 22, 1995

     2.   The Corporation is qualified to do business in The Commonwealth of
          Massachusetts.

     3.   The execution and delivery of the Agreement and the Registration
          Rights Agreement and the performance by the Corporation of its
          obligations thereunder have been duly authorized by all necessary
          corporate action on the part of the Corporation and do not violate or
          cause any default under any provision of (i) the Corporation's
          Certificate of Incorporation or By-Laws, or (ii) except where any such
          violation or default would not have a material adverse effect on the
          Corporation, any note, indenture, mortgage, lease, contract or other
          instrument, document or agreement to which the Corporation is a party
          and of which we have knowledge, or any writ, injunction, order,
          judgment or decree of any court, administrative agency or other
          governmental body to which the Company is a party and of which we have
          knowledge.  Each of the Agreement and the Registration Rights
          Agreement constitutes a valid and legally binding obligation of the
          Corporation, enforceable against the Corporation in accordance with
          its terms; provided, however, that we express no opinion as to the
          enforceability of the indemnification provisions contained in Section
          10 of the Registration Rights Agreement.

     4.   The sale of Initial Shares to each of you is not required to be
          registered under the Securities Act of 1933 or the Massachusetts
          Uniform Securities Act.

     5.   Upon receipt by the Corporation of the purchase price therefor, the
          Initial Shares will be validly issued, fully-paid and non-assessable.

     6.   No authorization, consent, approval or other order of, declaration to,
          or filing with, any governmental agency or body is required to be made
          or obtained by the Corporation for or in connection with the valid and
          lawful authorization, execution and delivery by the Corporation of the
          Agreement and the Registration Rights Agreement, for or in connection
          with the valid and lawful authorization, issuance, sale and delivery
          of the Initial Shares or for or in connection with the valid and
          lawful authorization, reservation, issuance, sale and delivery of the
          Reserved Shares to be issued upon the conversion of the Initial
          Shares, except such exemptive filings, if any, as are required to be
          made under applicable securities laws.

                                        Very truly yours,

                                        FOLEY, HOAG & ELIOT

                                       3

<PAGE>

                                                                    EXHIBIT 10.2


                        SERIES C CONVERTIBLE PREFERRED
                            STOCK PURCHASE AGREEMENT


     THIS AGREEMENT made as of the 8th day of May, 1997, by and among Sequenom,
Inc., a Delaware corporation (the "Corporation"); the several investors named on
the Schedule of Investors attached hereto (individually, an "Initial Investor",
    ---------------------
and collectively, the "Initial Investors"); such additional investors as may be
identified on such addenda to the Schedule of Investors as may be agreed upon by
                                  ---------------------
the Corporation and such additional investors in accordance with the terms of
this Agreement (individually, an "Additional Investor", and collectively, the
"Additional Investors")(the Initial Investors and the Additional Investors being
hereinafter sometimes referred to individually as an "Investor" and collectively
as the "Investors"); and, solely for purposes of Section 8.1 hereof, Hubert
Koster, Nola E. Masterson, and Robert E. Patterson (individually a "Founder" and
collectively the "Founders") and each holder of the Corporation's Series B
Convertible Preferred Stock (the "Series B Investors).

     WHEREAS, the Initial Investors wish to purchase from the Corporation, and
the Corporation wishes to sell to the Investors, up to an aggregate of 1,904,770
shares of the Corporation's Series C Convertible Preferred Stock, par value
$.001 per share (the "Series C Preferred"), and warrants to purchase up to an
aggregate of 190,477 shares of Series C Preferred;

     WHEREAS, the Corporation wishes to sell to the Additional Investors up to
an aggregate number of shares of Series C Preferred equal to the difference
between 3,174,604 and the number of shares of Series C Preferred sold at the
Initial Closing (as hereinafter defined); and

     WHEREAS, pursuant to that certain Stock Purchase Agreement dated December
22, 1995 (the "Series B Purchase Agreement") the Corporation granted certain
rights of first refusal to the Series B Investors and the Founders, and the
Corporation, such Series B Investors and the Founders now desire to replace such
rights of first refusal in the Series B Purchase Agreement with the rights of
first refusal set forth in Section 8.1 hereof.

     NOW, THEREFORE, in consideration of the premises and the mutual covenants
and agreements herein contained, the parties hereby agree as follows:

     SECTION 1.  Amendment of Certificate of Incorporation.  Immediately prior
     ---------   -----------------------------------------
to the execution and delivery of this Agreement, the Corporation filed with the
Secretary of State of Delaware a Certificate of Amendment (the "Certificate of
Amendment"), a copy of which is attached hereto as Exhibit 1, to its Certificate
                                                   ---------
of Incorporation (the Certificate of Incorporation of the Corporation, as
amended by the Certificate of Amendment and in effect on the date hereof being
hereinafter referred to as the "Certificate of Incorporation"), for the purpose
of increasing and amending the authorized capital stock of the Corporation and
setting forth the designations and the powers, preferences and rights, and the
qualifications, limitations and restrictions thereof, granted to or imposed upon
the capital stock of the Corporation or the holders thereof.

                                      -1-
<PAGE>

     SECTION 2.  Purchase and Sale of the Series C Preferred and Warrants.
     ---------   --------------------------------------------------------

          2.1  Initial Shares and Warrants.  Subject to the terms and conditions
               ---------------------------
of this Agreement, at the Initial Closing (as defined in Section 3.1), the
Corporation agrees to issue and sell to each Initial Investor the number of
shares of Series C Preferred set forth opposite the name of such Initial
Investor on the Schedule of Investors and a warrant in the form of Exhibit 2.1
                ---------------------                              -----------
(a "Warrant") to purchase a number of shares of Series C Preferred equal to the
largest whole number less than or equal to ten percent (10%) of the number of
shares of Series C Preferred being purchased by such Initial Investor at the
Initial Closing, at a purchase price equal to $3.15 per share of Series C
Preferred and associated warrant right to purchase one-tenth of a share of
Series C Preferred and an aggregate purchase price as set forth on the Schedule
                                                                       --------
of Investors, and each Initial Investor, acting severally and not jointly,
- ------------
hereby agrees to purchase from the Corporation such number of shares of Series C
Preferred and such Warrant at such purchase price.  The shares of Series C
Preferred sold at the Initial Closing are hereafter referred to as the "Initial
Shares."

          2.2  Additional Shares.  Subject to the terms and conditions of this
               -----------------
Agreement, from time to time after the Initial Closing, but on or before June
30, 1997, the Corporation agrees to issue and sell to one or more Additional
Investors who enter into this Agreement by executing one or more counterparts
hereof up to an aggregate number of shares of Series C Preferred equal to
3,174,604 minus the number of Initial Shares (the "Additional Shares").  By
executing such a counterpart, each such Additional Investor shall agree to
purchase that number of Additional Shares as may be set forth opposite its name
on such addenda to the Schedule of Investors which may be agreed upon between
                       ---------------------
the Corporation and each such Additional Investor, at the purchase price of
$3.15 per share and at the aggregate purchase price set forth opposite such
Additional Investor's name on such addenda.  Each such addendum shall be
executed by the Corporation and each such Additional Investor, a copy of each
such addendum shall be delivered to each Investor, and each such addendum shall
be deemed a part of this Agreement ab initio.  Initial Investors may become
                                   -- ------
Additional Investors.

     The Initial Shares and the Additional Shares are referred to collectively
hereinafter as the "Shares".  The shares of Series C Preferred issuable upon
exercise of Warrants are referred to collectively hereinafter as the "Warrant
Shares".

     SECTION 3.  Closings.
     ---------   --------

          3.1  Initial Closing.  The closing of the sale and purchase of the
               ---------------
Initial Shares and the Warrants (the "Initial Closing") shall take place
simultaneously with the execution of this Agreement at the offices of Foley,
Hoag & Eliot LLP, One Post Office Square, Boston, Massachusetts 02109, on May
___, 1997 (the "Initial Closing Date"), or at such other location, date and time
as may be agreed upon between the Initial Investors and the Corporation.  At the
Initial Closing, the Corporation shall issue and deliver to each Initial
Investor (i) a certificate or certificates registered in the name of such
Initial Investor, representing the Initial Shares being purchased by it at the
Initial Closing, and (ii) the Warrant being purchased by it at the Initial
Closing, registered in the name of such Initial Investor, against payment by
such Initial Investor to the Corporation of the purchase price therefor in the
form of (a) a check payable to the order

                                      -2-
<PAGE>

of the Corporation, (b) a wire transfer to the account of the Corporation, (c)
cancellation of indebtedness of the Corporation to such Investor or an affiliate
of such Investor, (d) conversion of convertible promissory notes issued by the
Corporation to such Investor or an affiliate of such Investor, or (e) any
combination thereof.

          3.2  Additional Closings.  The closings of the sale and purchase of
               -------------------
the Additional Shares under this Agreement (the "Additional Closings") shall
take place at such time, date and place as are mutually agreeable to the
Corporation and any Additional Investor, but such Additional Closings, if any,
shall take place on or before June 30, 1997.  At the Additional Closings, the
Corporation shall issue and deliver to each Additional Investor a certificate or
certificates registered in the name of such Additional Investor, representing
the Additional Shares being purchased by it at the Additional Closing, against
payment by such Additional Investor to the Corporation of the purchase price
therefor in the form of (a) a check payable to the order of the Corporation, (b)
a wire transfer to the account of the Corporation, (c) cancellation of
indebtedness of the Corporation to such Additional Investor or an affiliate of
such Additional Investor, (d) conversion of convertible promissory notes issued
by the Corporation to such Additional Investor or an affiliate of such
Additional Investor, or (e) any combination thereof.

     SECTION 4.  Representations and Warranties of the Corporation.  The
     ---------   -------------------------------------------------
Corporation hereby represents and warrants to the Investors as follows:

          4.1  Organization.  The Corporation is a corporation duly organized,
               ------------
validly existing and in good standing under the laws of the State of Delaware
and has all requisite corporate power and authority to own and lease its
properties, to carry on its business as presently conducted and as proposed to
be conducted and to carry out the transactions contemplated hereby.  Except as
set forth in Exhibit 4.1, the Corporation is duly qualified as a foreign
             -----------
corporation and is in good standing in all such other jurisdictions (which
jurisdictions are listed in Exhibit 4.1) in which the conductor its business or
                            -----------
its ownership or leasing of property requires such qualification and in which
the failure so to qualify or so to be in good standing would have a materially
adverse effect on the Corporation's operations or financial condition.  Exhibit
                                                                        -------
4.1 contains true, complete and accurate copies of the Certificate of
- ---
Incorporation and the By-Laws, as amended to date, of the Corporation (the
"ByLaws").

          4.2  Capitalization.  The entire authorized capital stock of the
               --------------
Corporation consists of:

               (a) 9,218,000 shares of Common Stock, par value $.001 per share
(the "Common Stock');

               (b) 1,650,000 shares of Series A Convertible Preferred Stock, par
value $.001 per share (the "Series A Preferred");

               (c) 2,976,663 shares of Series B Convertible Preferred Stock, par
value $.001 per share (the "Series B Preferred"); and

                                      -3-
<PAGE>

               (d) 3,365,081 shares of Series C Preferred.

     The number of shares of Common Stock, Series A Preferred and Series B
Preferred that are issued and outstanding or held as treasury shares as of the
date hereof is as set forth in Exhibit 4.2.  All issued and outstanding shares
                               -----------
of Common Stock, Series A Preferred and Series B Preferred are validly issued,
fully paid and nonassessable.  The number of shares of Common Stock reserved for
issuance upon the exercise of options granted and to be granted, and upon
conversion of the Series A Preferred, the Series B Preferred and the Series C
Preferred, is as set forth in Exhibit 4.2.  Prior to the Initial Closing, no
                              -----------
shares of Series C Preferred were issued or outstanding.

     Exhibit 4.2 contains a list of all holders of capital stock of the
     -----------
Corporation and options, warrants or rights to purchase such capital stock, in
each case including the number of shares of capital stock held by, or subject to
purchase pursuant to the exercise of any option, warrant or right held by, each
such holder.  Except as set forth in Exhibit 4.2, there are no outstanding
                                     -----------
shares of capital stock of the Corporation or warrants, options, agreements,
convertible securities or other commitments pursuant to which the Corporation is
or may become obligated to issue any shares of its capital stock or other
securities of the Corporation.  Except as set forth in Exhibit 4.2, the number
                                                       -----------
of shares of capital stock, if any, reserved for issuance in connection with the
securities described in the immediately preceding sentence is not subject to
adjustment by reason of the issuance of the Shares, the Warrants, the Warrant
Shares or the Reserved Shares (as defined in Section 4.16). Except as set forth
in Section 8.1 or in Exhibit 4.2, there are no preemptive or similar rights to
                     -----------
purchase or otherwise acquire shares of capital stock of the Corporation
pursuant to any provision of law, the Certificate of Incorporation or the By-
Laws or any agreement to which the Corporation is a party, or otherwise, and
except as set forth in the Voting Agreement, the Registration Rights Agreement
and the Stock Restriction Agreement described in Section 4.16 of this Agreement,
there is no agreement, restriction or encumbrance with respect to the sale or
voting of any shares of the Corporation's capital stock (whether outstanding or
issuable upon conversion or exercise of outstanding securities) imposed by or
through the Certificate of Incorporation, By-Laws or any agreement to which
the Corporation is a party.

          4.3  Equity Investments.  Except as set forth on Exhibit 4.3, the
               ------------------                          -----------
Corporation does not currently have any subsidiaries nor currently own any
capital stock or other proprietary interest, directly or indirectly, in any
corporation, association, trust, partnership, joint venture or other entity.

          4.4  Financial Statements.  Attached as Exhibit 4.4 are the unaudited
               --------------------               -----------
balance sheet for the Corporation as of December 31, 1996 (the "Balance Sheet"),
and the related unaudited statement of income for the year ended December 31,
1996. (the "Balance Sheet"). (December 31, 1996 is hereinafter sometimes
referred to as the "Balance Sheet Date.") The December 31, 1996 financial
statements are in accordance with the books and records of the Corporation and
present fairly the financial position and results of operations of the
Corporation as of the dates and for the periods indicated.

                                      -4-
<PAGE>

          4.5  Absence of Undisclosed Liabilities.  Except as set forth in
               ----------------------------------
Exhibit 4.5 or as reflected in the Balance Sheet, at the Balance Sheet Date (a)
- -----------
the Corporation had no material liabilities of any nature (matured or unmatured,
fixed or contingent) of a type required by generally accepted accounting
principles to be disclosed on a balance sheet of the Corporation which were not
so disclosed; (b) all reserves established by the Corporation and set forth in
the Balance Sheet were adequate; and (c) there were no loss contingencies (as
such term is used in Statement of Financial Accounting Standards No. 5 issued by
the Financial Accounting Standards Board in March 1975) which were not
adequately disclosed in the Balance Sheet as required by such Statement No. 5.

          4.6  Absence of Changes.  Except as set forth in Exhibit 4.6, since
               ------------------                          -----------
the Balance Sheet Date there has not been (a) any material adverse change in the
financial condition, results of operations, assets, liabilities, business or
prospects of the Corporation, (b) any material asset or property of the
Corporation made subject to a lien of any kind, (c) any waiver of any valuable
right of the Corporation, or the cancellation of any debt or claim held by the
Corporation, (d) any payment of dividends on, or other distribution with respect
to, or any direct or indirect redemption or acquisition of, any shares of the
capital stock of the Corporation, or any agreement or commitment therefor, (e)
any mortgage, pledge, sale, assignment or transfer of any tangible or intangible
assets of the Corporation, except in the ordinary course of business, (f) any
loan by the Corporation to, or any loan to the Corporation from, any officer,
director, employee or stockholder of the Corporation, or any agreement or
commitment therefor, (g) any damage, destruction or loss (whether or not covered
by insurance) materially and adversely affecting the assets, property or
business of the Corporation, or (h) any change in the accounting methods or
practices followed by the Corporation.

          4.7  Encumbrances.  Except as set forth in Exhibit 4.7, the
               ------------                          -----------
Corporation has good title to all of its property and assets, real, personal or
mixed, tangible or intangible, free and clear of all liens, security interests,
charges and other encumbrances of any kind.

          4.8  Intellectual Property Rights.  Except in each case as set forth
               ----------------------------
in Exhibit 4.8:
   -----------

               (a) the Corporation owns or has the right to use all Intellectual
Property Rights (as hereinafter defined) necessary or required for the conduct
of its business as presently conducted or as proposed to be conducted, which
Intellectual Property Rights are identified in said Exhibit 4.8;
                                                    -----------

               (b) to the Corporation's knowledge, no royalties or other amounts
are payable by the Corporation to other persons by reason of the ownership or
use of said Intellectual Property Rights; and

               (c) to the Corporation's knowledge, no product marketed or sold
or proposed to be marketed or sold by the Corporation violates or will violate
any license or infringes any Intellectual Property Rights of another, nor has
the Corporation received any notice that any of such Intellectual Property
Rights or the operation or proposed operation of the Corporation's business
conflicts or will conflict with the rights of others.

                                      -5-
<PAGE>

As used herein, the term "Intellectual Property Rights" means all patents,
trademarks, service marks, trade names, copyrights, inventions, trade secrets,
proprietary processes and formulae, applications for patents, trademarks,
service marks and copyrights, and other industrial and intellectual property
rights.

          Dr. Hubert Koster has entered into agreements with the Company
relating to protection of proprietary information and invention assignment in
the form referred to in Exhibit 4.8.
                        -----------

          4.9  Litigation.  There is no action, suit, claim, proceeding or
               ----------
investigation, at law, in equity or otherwise, or by or before any governmental
instrumentality or other agency, now pending, or, to the Corporation's
knowledge, threatened against the Corporation.

          4.10  No Defaults.  The Corporation is not in violation or breach of,
                -----------
or in default under, any provision of (a) the Certificate of Incorporation or
the By-Laws or (b) except where any such violation, breach or default would not
have a material adverse effect on the Corporation, any note, indenture,
mortgage, lease, contract, purchase order or other instrument, document or
agreement to which the Corporation is a party or by which it or any of its
property is bound or affected or any ruling, writ, injunction, order, judgment
or decree of any court, administrative agency or other governmental body.  To
the Corporation's knowledge, there exists no condition, event or act which after
notice, lapse of time, or both, would constitute a violation or breach of, or a
default under, any of the foregoing.

          4.11  Employment of Officers Employees and Consultants.  No third
                ------------------------------------------------
     party may assert any valid claim against the Corporation, any Investor, or
any Designated Person (as hereinafter defined) with respect to (a) the continued
employment by or association with the Corporation of any of the present officers
or key employees of, or consultants to, the Corporation (collectively, the
"Designated Persons"), or (b) the use or disclosure by the Corporation or any
Designated Person of any information which the Corporation or any Designated
Person would be prohibited from using or disclosing under any prior agreements
or arrangements or under any laws, including, without limitation, laws
applicable to unfair competition, trade secrets or proprietary information.

          4.12  Taxes.  The Corporation has filed all Federal, state, local and
                -----
foreign tax returns which are required to be filed by it and all such returns
are true and correct.  The Corporation has paid all taxes pursuant to such
returns or pursuant to any assessments received by it or which it is obligated
to withhold from amounts owing to any employee, creditor or third party, except,
in each case, for those which are not yet due and payable pursuant to such
returns.

          4.13  Agreements.  Except as set forth in Exhibit 4.13, the
                ----------                          ------------
Corporation is not a party to any written or oral (a) contract with any labor
union; (b) contract for the future purchase of fixed assets or for the future
purchase of materials, supplies or equipment in excess of normal operating
requirements; (c) contract for the employment of any officer, individual
employee or other person or any contract with any person on a consulting basis;
(d) bonus, pension, profit-sharing, retirement, stock purchase, stock option,
hospitalization, medical insurance or similar

                                      -6-
<PAGE>

plan, contract or understanding in effect with respect to employees or any of
them or the employees of others; (e) agreement or indenture relating to the
borrowing of money or to the mortgaging, pledging or otherwise placing a lien on
any assets of the Corporation; (f) guaranty of any obligation for borrowed money
or otherwise; (g) lease or agreement under which the Corporation is lessee of or
holds or operates any property, real or personal, owned by any other party; (h)
lease or agreement under which the Corporation is lessor of or permits any third
party to hold or operate any property, real or personal, owned or controlled by
the Corporation; (i) license or lease agreement with respect to any Intellectual
Property Rights; (j) agreement or other commitment for capital expenditures in
excess of $25,000; or (k) contract, agreement or commitment under which the
Corporation is obligated to pay any broker's fees, finder's fees or any such
similar fees, to any third party. Except as set forth in Exhibit 4.13, the
                                                         ------------
Corporation is not engaged in any negotiations which could lead to any such
contract, agreement, arrangement, understanding or commitment. The Corporation
has furnished to the Investors true and correct copies of all such agreements
and other documents requested by the Investors or its authorized
representatives.

          4.14  Compliance.  The Corporation has complied in all material
                ----------
respects with all Federal, state, local or foreign laws applicable to its
business.  The Corporation has all Federal, state, local and foreign
governmental licenses, registrations and permits material to or necessary for
the conduct of its business, and such licenses, registrations and permits are in
full force and effect and there have been no violations in any material respect
of any such licenses, registrations or permits.  No proceeding is pending or, to
the Corporation's knowledge, threatened, to revoke or limit any thereof.

          4.15  Insurance.  Exhibit 4.15 sets forth each insurance policy
                ---------   ------------
(specifying the insurer, the amount of coverage, the type of insurance, the
policy number, the expiration date, the annual premium and any pending claims
thereunder) maintained by the Corporation on its properties, assets, business or
personnel.  The insurance maintained by the Corporation on its properties,
assets, business and personnel is in amounts deemed adequate by the Corporation,
is in accordance with the standards of the industry in which the Corporation
operates, and is under policies currently in effect and issued by insurers of
recognized responsibility.

          4.16  Authorization of this Agreement.  The execution, delivery and
                -------------------------------
performance by the Corporation of this Agreement, the Registration Rights
Agreement of even date herewith by and among the Corporation, the Investors and
certain additional parties identified therein, which agreement is in the form of
Exhibit 4.16A (the "Registration Rights Agreement"), the Voting Agreement of
- -------------
even date herewith by and among the Corporation, the Investors and certain
additional parties identified therein, which agreement is in the form of Exhibit
                                                                         -------
4.16B (the "Voting Agreement"), and the Stock Restriction Agreement of even date
- -----
herewith by and among the Corporation, the Investors and certain additional
parties identified therein, which agreement is in the form of Exhibit 4.16C (the
                                                              -------------
"Stock Restriction Agreement"; this Agreement, the Registration Rights
Agreement, the Voting Agreement and the Stock Restriction Agreement are
hereinafter referred to collectively as the "Transaction Documents") have been
duly authorized by all requisite corporate action.  The Transaction Documents
have been duly executed and delivered on behalf of the Corporation and
constitute the valid and binding obligations of the Corporation, enforceable in
accordance with their respective terms.

                                      -7-
<PAGE>

The execution, delivery and performance of the Transaction Documents, the
issuance, sale and delivery of the Shares, the Warrants, the Warrant Shares and
the shares of Common Stock issuable upon conversion of the Shares and the
Warrant Shares (collectively, the "Reserved Shares"), and compliance with the
provisions hereof and thereof by the Corporation, do not and will not, with or
without the passage of time or the giving of notice or both, (a) violate any
provision of law, statute, rule or regulation or any ruling, writ, injunction,
order, judgment or decree of any court, administrative agency or other
governmental body or (b) conflict with or result in any breach of any of the
terms, conditions or provisions of, or constitute a default (or give rise to any
right of termination, cancellation or acceleration) under, or result in the
creation of any lien, security interest, charge or encumbrance upon any of the
properties or assets of the Corporation under, the Certificate of Incorporation
or By-Laws or any note, indenture, mortgage, lease, contract, purchase order or
other instrument, document or agreement to which the Corporation is a party or
by which it or any of its property is bound or affected.

          4.17  Authorization of Shares and Warrants.  The issuance, sale and
                ------------------------------------
delivery hereunder by the Corporation of the Shares and the Warrants have been
duly authorized by all requisite corporate action, and when so issued, sold and
delivered, the Shares will be fully paid and nonassessable and the Shares and
the Warrants will be validly issued and outstanding and not subject to
preemptive or any other similar rights of the stockholders of the Corporation or
others.

          4.18  Authorization of Warrant Shares and Reserved Shares.  The
                ---------------------------------------------------
issuance, sale and delivery by the Corporation of the Warrant Shares and the
Reserved Shares have been duly authorized by all requisite corporate action of
the Corporation, and the Warrant Shares and the Reserved Shares have been duly
reserved for issuance upon exercise of the Warrants and conversion of the Shares
and the Warrant Shares, and when so issued, sold and delivered upon exercise of
the Warrants and conversion of the Shares and the Warrant Shares, the Warrant
Shares and the Reserved Shares will be validly issued and outstanding, fully
paid and nonassessable, and not subject to preemptive or any other similar
rights of the stockholders of the Corporation or others.

          4.19  Related Transactions.  Except as set forth in Exhibit 4.19, no
                --------------------                          ------------
director, officer or employee of the Corporation nor any "associate" (as defined
in the rules and regulations promulgated under the Securities Exchange Act of
1934 (the "Exchange Act") of any such person is indebted to the Corporation, nor
is the Corporation indebted (or committed to make loans or extend or guarantee
credit) to any such person, nor is any such person a party to any transaction
(other than as an employee or consultant) with the Corporation providing for the
furnishing of services by, or rental of real or personal property from, or
otherwise requiring cash payments to, any such person.

          4.20  No Governmental Consent or Approval Required.  Except as set
                --------------------------------------------
forth in Exhibit 4.20, no authorization, consent, approval or other order of,
         ------------
declaration to, or filing with, any governmental agency or body is required to
be made or obtained by the Corporation for or in connection with the valid and
lawful authorization, execution and delivery by the Corporation of the
Transaction Documents, for or in connection with the valid

                                      -8-
<PAGE>

and lawful authorization, issuance, sale and delivery of the Shares or the
Warrants or for or in connection with the valid and lawful authorization,
reservation, issuance, sale and delivery of the Reserved Shares, except such
exemptive filings as are required to be made under applicable securities laws
and have been and shall be made on a timely basis.

          4.21  Registration Rights.  Except as contemplated by the Registration
                -------------------
Rights Agreement, no person has any right to cause the Corporation to effect the
registration under the Securities Act of 1933, as amended (the "Securities
Act"), of any securities of the Corporation.

          4.22  Exemptions from Securities Laws.  Subject to the accuracy of the
                -------------------------------
representations and warranties of the Investors set forth in Section 5 hereof,
the provisions of Section 5 of the Securities Act are inapplicable to the
offering, issuance, sale and delivery of the Shares, the Warrants and the
Reserved Shares, and no consent, approval, qualification or registration or
filing under any state securities laws is required in connection therewith,
except such exemptive filings as are required to be made under applicable
securities laws and have been and shall be made on a timely basis.

          4.23  Commitments from German Government.  Exhibit 4.23 accurately
                ----------------------------------   ------------
describes certain commitments from certain German governmental authorities made
with respect to the Corporation and its subsidiary Sequenom Instruments GmbH.

     SECTION 5.  Representations and Warranties of the Investors.  Each
     ---------   -----------------------------------------------
Investor, severally and not jointly, represents and warrants to the Corporation
as follows:

          5.l  Organization.  Such Investor is an entity duly organized, validly
               ------------
existing and in good standing under the laws of the jurisdiction of its
organization, with all requisite power and authority to own and lease its
properties, to carry on its business, and to carry out the transactions
contemplated hereby.

          5.2  Purchase for Investment.  Such Investor is acquiring the Shares,
               -----------------------
any Warrant purchasable by it hereunder, and, in the event such Investor should
acquire Warrant Shares upon exercise of such Warrant or Reserved Shares upon
conversion of the Shares or Warrant Shares, such Investor will be acquiring such
Warrant Shares and Reserved Shares, for its own account, for investment and not
for, with a view to, or in connection with, any distribution or public offering
thereof within the meaning of the Securities Act.

          5.3  Unregistered Securities; Legend.  Such Investor understands that
               -------------------------------
the Shares and the Warrants have not been, and the Warrant Shares and Reserved
Shares will not be, registered under the Securities Act or any state securities
law, by reason of their issuance in a transaction exempt from the registration
requirements of the Securities Act and such laws, and that they must be held
indefinitely unless they are subsequently registered under the Securities Act
and such laws or a subsequent disposition thereof is exempt from registration.
Such Investor further understands that such exemption depends upon, among other
things, the bona fide nature of such Investor's investment intent expressed
            ---- ----
herein.  Such Investor acknowledges that the Warrants and the certificates for
the Shares, the Warrant Shares and the Reserved Shares shall bear a legend to
such effect, and appropriate transfer instructions may be issued.

                                      -9-
<PAGE>

          5.4  Status of the Investors.  Such Investor has not been formed for
               -----------------------
the specific purpose of acquiring Shares, Warrants, Warrant Shares or Reserved
Shares pursuant to this Agreement.  Such Investor understands the term
"accredited investor," as used in Regulation D promulgated under the Securities
Act and represents and warrants to the Corporation that such Investor is an
"accredited investor" for purposes of acquiring Shares, Warrants, Warrant Shares
and Reserved Shares.

          5.5  Knowledge and Experience; Economic Risk.  Such Investor has
               ---------------------------------------
     sufficient knowledge and experience in business and financial matters and
with respect to investment in securities of privately held companies so as to
enable it to analyze and evaluate the merits and risks of the investment
contemplated hereby and is capable of protecting its interest in connection with
this transaction. Such Investor is able to bear the economic risk of such
investment, including a complete loss of the investment.

          5.6  Access to Information.  Such Investor acknowledges that such
               ---------------------
Investor and its representatives have had the opportunity to ask questions and
receive answers from officers and representatives of the Corporation concerning
the transactions contemplated by this Agreement, and to obtain any additional
information which the Corporation possesses or can acquire that is necessary to
verify the accuracy of the information regarding the Corporation herein set
forth or otherwise desired in connection with its purchase of the Shares and any
Warrants purchasable by it.

          5.7  Authorization.  The execution, delivery and performance by such
               -------------
Investor of this Agreement have been duly authorized by all requisite action of
such Investor and its partners or equity holders.  This Agreement has been duly
executed and delivered on behalf of such Investor and constitutes the valid and
binding obligation of such Investor, enforceable in accordance with its terms.
The execution, delivery and performance of the Transaction Documents, the
purchase of the Shares and any Warrants purchasable by such Investor, the
exercise of any such Warrants, and compliance with the provisions hereof and
thereof by such Investor, do not and will not, with or without the passage of
time or the giving of notice or both, (a) violate any provision of law, statute,
rule or regulation or any ruling, writ, injunction, order, judgment or decree of
any court, administrative agency or other governmental body or (b) conflict with
or result in any breach of any of the terms, conditions or provisions of, or
constitute a default (or give rise to any right of termination, cancellation or
acceleration) under, such Investor's charter, by-laws, partnership agreement or
other organizational document, or any material note, indenture, mortgage, lease,
agreement, contract, purchase order or other instrument, document or agreement
to which such Investor is a party or by which it or any of its property is bound
or affected.

          5.8  No Governmental Consent or Approval Required. No authorization,
               --------------------------------------------
consent, approval or other order of, or declaration to, or filing with, any
governmental agency or body is required to be made or obtained by such Investor
for or in connection with the valid authorization, execution and delivery by
such Investor of the Transaction Documents or for the valid purchase by such
Investor of the Shares and any Warrants to be sold to it hereunder or for or in
connection with the valid exercise of any such Warrant or issuance to such
Investor of any Warrant Shares or Reserved Shares.

                                      -10-
<PAGE>

          5.9  Rule 144.  Such Investor understands that the exemption from
               --------
registration afforded by Rule 144 (the provisions of which are known to such
Investor) promulgated by the Securities and Exchange Commission (the
"Commission") under the Securities Act depends upon the satisfaction of various
conditions, that such exemption is not currently available and that, if
applicable, Rule 144 affords the basis for sales only in limited amounts.

     SECTION 6.  Conditions Precedent to Closing by the Investor.  The
     ---------   -----------------------------------------------
obligation of each Investor to purchase and pay for the Shares and any Warrants
being purchased by such Investor at the Initial Closing or any Additional
Closing (each a "Closing") is subject to satisfaction (or waiver by the
Investor) of the following conditions precedent at or before such Closing:

          6.1  Corporate Proceedings.  All corporate and other proceedings to be
               ---------------------
taken and all waivers and consents to be obtained in connection with the
transactions contemplated by this Agreement shall have been taken or obtained
and all documents incident to such transactions shall be satisfactory in form
and substance to the Investors and their counsel, who shall have received all
such originals or certified or other copies of such documents as they may
reasonably request.

          6.2  Representations and Warranties Correct.  The representations and
               --------------------------------------
warranties made by the Corporation in Section 4 hereof shall be true and correct
when made, and shall be true and correct in all material respects at the time of
such Closing with the same force and effect as if they had been made at and as
of the time of such Closing.

          6.3  Compliance with Covenants.  The Corporation shall have duly
               -------------------------
complied with and performed all covenants and agreements of the Corporation
herein which are required to be complied with and performed at or before such
Closing.

          6.4  Certificate of Compliance.  The Corporation shall have provided
               -------------------------
to each of the Investors purchasing Shares at such Closing a certificate, dated
the date of such Closing, in form and substance reasonably satisfactory to such
Investor, confirming compliance with the conditions set forth in Sections 6.2
and 6.3.

          6.5  Opinion of Counsel.  At such Closing, each of the Investors
               ------------------
purchasing Shares at such Closing shall have received from Foley, Hoag & Eliot
LLP, counsel for the Corporation, an opinion addressed to such Investors, dated
the date of such Closing, to the effect set forth in Exhibit 6.5.
                                                     -----------

          6.6  Related Agreements and Documents.  At or before such Closing, the
               --------------------------------
parties thereto shall have executed and delivered the Registration Rights
Agreement, the Voting Agreement and the Stock Restriction Agreement, and the
Corporation shall have delivered to the Investors such other documents as they
shall reasonably request.

          6.7  Blue Sky Matters.  All consents, approvals, qualifications,
               ----------------
registrations and filings required to be obtained or effected under any
applicable state securities or "blue sky" laws in connection with the issuance,
sale and delivery of the Shares and the Warrants prior to

                                      -11-
<PAGE>

the sale of the Shares or the Warrants shall have been obtained or effected and
copies of the same delivered to each of the Investors.

          6.8  Purchase by Other Investors.  All of the Initial Shares and the
               ---------------------------
Warrants shall have been purchased and paid for at the Initial Closing.

     SECTION 7.  Financial Reports.  Subject to the limitations set forth in
     ---------   -----------------
Section 7.6, the Corporation agrees to furnish each of the Investors and any
transferee to which any Investor transfers at least 100,000 Shares (a "Series C
Transferee") with the following:

          7.1  Quarterly and Monthly Reports.  Within 45 days after the end of
               -----------------------------
each month and each fiscal quarter, an unaudited financial report of the
Corporation, which report shall be prepared in accordance with generally
accepted accounting principles consistently applied (except that the financial
report may (i) be subject to normal year-end audit adjustments neither
individually nor in the aggregate material and (ii) not contain all notes
thereto which may be required in accordance with generally accepted accounting
principles) and shall be certified by either the Chief Executive Officer or the
Chief Financial officer of the Corporation to have been so prepared, and which
shall include the following:

          (a) an income statement for such month or quarter, together with a
cumulative income statement from the first day of the then-current fiscal year
to the last day of such month or quarter;

          (b) a balance sheet as of the last day of such month or quarter;

          (c) a statement of cash flows for such month or quarter;

          (d) a comparison between the actual figures for such month or quarter,
the comparable figures (with respect to the foregoing clauses (a) and (b) only)
for the prior year (if any) and the comparable figures included in the Budget
(as hereinafter defined) for such month or quarter, with an explanation of any
material differences between them.

     The financial report for each fiscal quarter shall be accompanied by a
report by the Chief Executive Officer of the Corporation explaining business
developments and problems occurring during the quarter.

          7.2  Annual Reports.  Within 120 days after the end of each fiscal
               --------------
year of the Corporation, audited financial statements of the Corporation, which
shall include an income statement for such fiscal year and a balance sheet as of
the last day thereof, and statements of stockholders' equity and cash flows for
such fiscal year, each prepared in accordance with generally accepted accounting
principles consistently applied, certified by independent certified public
accountants of recognized national standing satisfactory to the Investors,
together with such accountants' annual management letter.

          7.3  Consolidated Financial Statements.  If for any period the
               ---------------------------------
Corporation shall have any subsidiary whose accounts are consolidated with those
of the Corporation, then in

                                      -12-
<PAGE>

respect of such period the financial statements delivered pursuant to the
foregoing Sections 7.1 and 7.2 shall be the consolidated and consolidating
financial statements of the Corporation and all such consolidated subsidiaries.

          7.4  Other Reports and Information.  Promptly upon becoming available:
               -----------------------------

               (a) copies of all financial statements, reports, notices, press
     releases, proxy statements and other documents sent by the Corporation to
     its stockholders or released to the public and copies of all regular and
     periodic reports, if any, filed by the Corporation with the Commission or
     any securities exchange; and

               (b) any other financial or other information available to
     management of the Corporation as any of the Investors shall have reasonably
     requested on a timely basis.

          7.5  Budgets and Operating Plans.  At least 30 days prior to the
               ---------------------------
beginning of each fiscal year of the Corporation, a monthly operating plan of
the Corporation, with monthly breakdowns, for such fiscal year (the "Budget").
The Budget shall be accepted as the Budget for such fiscal year when it has been
approved by the Board of Directors of the Corporation.  The Budget shall be
reviewed by the Corporation periodically and all changes therein and all
material deviations therefrom which are proposed to be made by the Corporation
shall be resubmitted to its Board of Directors and to each of the Investors in
advance and shall be accepted when approved by, and the Corporation shall not
make any such changes or material deviations to or from the Budget without such
prior approval of, its Board of Directors.  The Budget shall include an income
statement, balance sheet and cash flow information.

          7.6  Limitations on Rights of Investors under Section 7. The
               --------------------------------------------------
Corporation shall provide the information required by Sections 7.1 through 7.5
to each Investor and any Series C Transferee so long as such Investor or Series
C Transferee shall own at least 100,000 shares of the Common Stock (including in
such number shares of Common Stock issuable upon Conversion of Series C
Preferred) appropriately adjusted to take account of any stock split, stock
dividend, combination of shares or the like.  The foregoing provisions of this
Section 7 to the contrary notwithstanding, the Investors shall not have any
rights and the Corporation shall not have any obligations under the foregoing
provisions of this Section 7 at such time that the Common Stock is registered
under Section 12 of the Exchange Act.

     SECTION 8.  Additional Agreements of the Corporation.
     ---------   ----------------------------------------

          8.1  Right of First Refusal.
               ----------------------

               (a) Subject to the limitations set forth in paragraph (i) of this
Section 8.1 and in Section 8.9, the Corporation hereby grants to each Investor,
each Series B Investor, each Founder, and any of their respective permitted
assignees described in paragraph (j) of this Section 8.1 (each a "Right Holder")
the right of first refusal to purchase, pro rata, all (or any part) of any New
Securities (as defined in this Section 8.1 (b)) that the Corporation may, from
time to time, propose to sell or issue.  Each such Right Holder's pro rata
share, for purposes of

                                      -13-
<PAGE>

this right of first refusal, is the ratio of (i) the number of shares of Common
Stock then held of record by, or issuable on conversion of Series C Preferred,
Series B Preferred or Series A Preferred (collectively, "Preferred Stock") then
held of record by, such Right Holder to (ii) the sum of the total number of
shares of the Common Stock issued and outstanding plus the total number of
shares of Common Stock issuable upon conversion of the Preferred Stock, in each
case at such time (the "Basic Amount").

          (b) "New Securities" shall mean any equity securities of the
Corporation, whether now authorized or not, and rights, options, or warrants to
purchase said equity securities, and securities of any type whatsoever that are,
or may become, convertible into said equity securities; provided, however, that
                                                        --------  -------
"New Securities" does not include (i) securities offered to the public pursuant
to a registration statement filed under the Securities Act, the gross proceeds
to the Corporation from the sale of which would equal or exceed $20,000,000;
(ii) securities issued pursuant to the acquisition of another corporation by the
Corporation by merger, purchase of substantially all of the assets, or other
reorganization whereby the Corporation acquires not less than 51 % of the voting
power of such corporation; (iii) up to 1,200,000 shares (appropriately adjusted
to take account of any stock split, stock dividend, combination of shares or the
like) of Common Stock (or related options) issued to employees, officers or
other persons performing services for the Corporation pursuant to any stock
offering, plan or arrangement approved by the Board of Directors of the
Corporation, which number may be adjusted upward by the affirmative vote of two-
thirds of the whole Board of Directors; (iv) securities issued in connection
with any stock split, stock dividend or recapitalization by the Corporation; (v)
shares of Common Stock issued upon conversion of the Shares or the Warrant
Shares; (vi) securities issuable upon exercise or conversion of any rights,
options, warrants or convertible securities outstanding on the date of this
Agreement; (vii) securities issued to any financial institution in connection
with a loan transaction approved by the Board of Directors of the Corporation;
(viii) securities issued to vendors or customers or to other persons in similar
commercial situations with the Corporation, provided such issuance is approved
by the Board of Directors of the Corporation; (ix) securities issued in
connection with obtaining lease financing, whether issued to a lessor, guarantor
or other person involved in the financing, provided such issuance is approved by
the Board of Directors of the Corporation; (x) the Additional Shares; or (xi)
any right, option or warrant to acquire any security convertible into securities
excluded from the definition of New Securities pursuant to clauses (i) through
(x) above.

          (c) The Corporation shall not issue, sell or exchange, agree to issue,
sell or exchange, or reserve or set aside for issuance, sale or exchange any New
Securities unless the Corporation shall deliver to each Right Holder a written
notice of any proposed or intended issuance, sale or exchange of New Securities
(the "Offer"), which Offer shall (i) identify and describe the New Securities,
(ii) describe the price and other terms upon which they are to be issued, sold
or exchanged, and the number or amount of the New Securities to be issued, sold
or exchanged, (iii) identify the persons or entities to which or with which the
New Securities are to be offered, issued, sold or exchanged and (iv) offer to
issue and sell to or exchange with such Right Holder (a) such Right Holder's
Basic Amount, and (b) any additional portion of the New Securities as such Right
Holder shall indicate it will purchase or acquire should the other Right Holders
subscribe for less than their Basic Amounts (the "Undersubscription Amount").
Each Right Holder shall have the right, for a period of 30 days following
delivery of the Offer, to

                                      -14-
<PAGE>

purchase or acquire, at a price and upon the other terms specified in the Offer,
the number or amount of New Securities described above. The Offer by its terms
shall remain open and irrevocable for such 30-day period.

          (d) To accept an Offer, in whole or in part, a Right Holder must
deliver a written notice to the Corporation prior to the end of the 30-day
period of the Offer, setting forth the portion of the Right Holder's Basic
Amount that such Right Holder elects to purchase and, if such Right Holder shall
elect to purchase all of its Basic Amount, the Undersubscription Amount (if any)
that such Right Holder elects to purchase (the "Notice of Acceptance"). If the
Basic Amounts subscribed for by all Right Holders are less than the total New
Securities, then each Right Holder who has set forth an Undersubscription Amount
in its Notice of Acceptance shall be entitled to purchase, in addition to the
Basic Amount subscribed for, the Undersubscription Amount it has subscribed for;
provided, however, that should the Undersubscription Amounts subscribed for
- -----------------
exceed the difference between the New Securities and the Basic Amounts
subscribed for (the "Available Undersubscription Amount"), each Right Holder who
has subscribed for any Undersubscription Amount shall be entitled to purchase
only that portion of the Available Undersubscription Amount as the
Undersubscription Amount subscribed for by such Right Holder bears to the total
Undersubscription Amounts subscribed for by all Right Holders, subject to
rounding by the Board of Directors to the extent it reasonably deems necessary.

          (e) In the event that Notices of Acceptance are not given by the Right
Holders in respect of all the New Securities, the Corporation shall have 90 days
from the expiration of the period set forth in paragraph (c) above to issue,
sell or exchange all or any part of such New Securities as to which a Notice of
Acceptance has not been given by the Right Holders (the "Refused Securities"),
but only to the offerees or purchasers and only upon terms and conditions
(including, without limitation, unit prices and interest rates) which are
described in the Offer.

          (f) In the event the Corporation shall propose to sell less than all
the Refused Securities (any such sale to be in the manner and on the terms
specified in paragraph (e) above), then each Right Holder may, at its sole
option and in its sole discretion, reduce the number or amount of the New
Securities specified in its Notice of Acceptance to an amount that shall be not
less than the number or amount of the New Securities that the Right Holder
elected to purchase pursuant to paragraph (d) above multiplied by a fraction,
(i) the numerator of which shall be the number or amount of New Securities the
Corporation actually proposes to issue, sell or exchange (including New
Securities to be issued or sold to Right Holders pursuant to paragraph (d) above
prior to such reduction) and (ii) the denominator of which shall be the amount
of all New Securities.  In the event that any Right Holder so elects to reduce
the number or amount of New Securities specified in its Notice of Acceptance,
the Corporation may not issue, sell or exchange more than the reduced number or
amount of the New Securities unless and until such securities have again been
offered to the Right Holders in accordance with paragraph (c) above.

          (g) Upon the closing of the issuance, sale or exchange of all or less
than all the Refused Securities, the Right Holders shall acquire from the
Corporation, and the

                                      -15-
<PAGE>

Corporation shall issue to the Right Holders, the number or amount of New
Securities specified in the Notices of Acceptance, as reduced pursuant to
paragraph (f) above if the Right Holders have so elected, upon the terms and
conditions specified in the Offer. The purchase by the Right Holders of any New
Securities is subject in all cases to the preparation, execution and delivery by
the Corporation and the Right Holders of a purchase agreement relating to such
New Securities reasonably satisfactory in form and substance to the Right
Holders and their respective counsel.

          (h) Any New Securities not acquired by the Right Holders or other
persons in accordance with paragraph (e) above may not be issued, sold or
exchanged until they are again offered to the Right Holders under the procedures
specified in this Agreement.

          (i) This right of first refusal shall run to each Investor, each
Series B Investor, each Founder and any of their respective permitted assignees
under paragraph (j) of this Section 8.1 only for so long as they hold the
following number of shares of Common Stock (including in such number shares of
Common Stock issuable upon conversion of Preferred Stock):

              (i)  in the case of the Founders and the Series B Investors who
were parties to the Stock Purchase Agreement dated May 26, 1994, and their
respective permitted assignees, 50,000 shares; and

              (ii) in the case of all other Series B Investors and the
Investors, and their respective permitted assignees, 200,000 shares (including
shares held by their respective Affiliates (as hereinafter defined)).

          (j) This right of first refusal may be assigned, in whole or in part,
(i) to any Affiliate (as hereinafter defined) of any Right Holder or (ii) to any
assignee who acquires not less than 50,000 shares of Common Stock in the case of
an assignment from assignor described in clause (i) of paragraph (i) of this
Section 8.1, or 200,000 shares of Common Stock in the case of an assignment from
an assignor described in clause (ii) of paragraph (i) of this Section 8.1 (in
each case, including in such number shares of Common Stock issuable upon
conversion of Preferred Stock and appropriately adjusted to take account of any
stock split, stock dividend, combination of shares, or the like).  As used in
this Section, an Affiliate of a Right Holder shall mean any partner of the Right
Holder that is a partnership or any person or entity that, directly or
indirectly, through one or more intermediaries, controls, or is controlled by,
or is under common control with, the Right Holder.

          (k) This Section 8.1 shall supersede and replace Section 8.1 of the
Series B Purchase Agreement, which Section 8.1 shall no longer have any force or
effect.  Without limiting the generality of the foregoing, the Right Holders
under Section 8.1 of the Series B Purchase Agreement hereby consent to the sale
of the Shares and the Warrants and waive their rights of first refusal under
Section 8.1 of the Series B Purchase Agreement (including their rights to notice
thereunder) in connection with the issuance and sale of the Shares and the
Warrants, the issuance of the Warrant Shares upon exercise of the Warrants, and
the issuance of the Reserved Shares upon conversion of the Shares and the
Warrant Shares.

                                      -16-
<PAGE>

     8.2  Keeping of Records and Books of Account.  The Corporation shall keep,
          ---------------------------------------
and cause each subsidiary to keep, adequate records and books of account, in
which complete entries will be made in accordance with generally accepted
accounting principles consistently applied, reflecting all financial
transactions of the Corporation and such subsidiary, and in which, for each
fiscal year, all proper reserves for depreciation, depletion, obsolescence,
amortization, taxes, bad debts and other purposes in connection with its
business shall be made.

     8.3  Insurance.  The Corporation will do or cause to be done all things
          ---------
necessary to preserve and maintain in full force and effect fire and casualty
insurance policies, with extended coverage, on its properties, assets, business
and personnel, in amounts deemed adequate by the Corporation, and in accordance
with the standards of the industry in which the Corporation operates, sufficient
in amount to allow it to replace any of its properties which might be damaged or
destroyed.

     8.4  Key Man Life Insurance.  The Corporation shall use its best efforts to
          ----------------------
maintain in force a policy of life insurance, naming the Corporation as
beneficiary, on the life of Dr. Hubert Koster, in the amount of US$1,000,000.

     8.5  Maintenance of Corporate Existence, etc.  The Corporation will do or
          ---------------------------------------
cause to be done all reasonable things necessary to preserve and keep in full
force and effect its existence and all of its rights (charter and statutory),
subject in all cases to the exercise by the Board of Directors of the
Corporation of their fiduciary obligations.  The Corporation shall comply in all
respects with the provisions of its Certificate of Incorporation and By-laws.

     8.6  Maintenance of Facilities.  The Corporation will cause all facilities
          -------------------------
owned or leased in the conduct of its business to be maintained and kept in good
condition and repair and will cause to be made all necessary repairs, renewals,
replacements, betterments and improvements thereof, all as in the judgment of
the Corporation may be necessary so that the business carried on in connection
therewith may be properly and advantageously conducted at all times; provided,
                                                                     --------
however, that nothing in this Section shall prevent the Corporation from
- -------
discontinuing the lease or maintenance of any such facilities if such
discontinuance is, in the good faith judgment of the Board of Directors of the
Corporation, desirable in the conduct of its business and would not have a
material adverse effect on the Corporation.

     8.7  Payment of Taxes.  The Corporation will pay or discharge or cause to
          ----------------
be paid or discharged, before the same shall become delinquent, (1) all material
taxes, assessments and governmental charges levied or imposed upon the
Corporation or upon the income, profits or property of the Corporation; and (2)
all material liabilities of the Corporation; provided, however, that the
                                             --------  -------
Corporation shall not be required to pay or discharge or cause to be paid or
discharged any such tax assessment, liability, or charge, whose amount,
applicability or validity is being contested in good faith by appropriate
proceedings if adequate reserves therefor have been established in accordance
with generally accepted accounting principles.

                                      -17-
<PAGE>

     8.8  Compliance with Applicable Laws.  The Corporation shall conduct its
          -------------------------------
business in compliance in all material respects with all laws and valid
requirements of governmental authorities relating to the conduct of its business
or to its properties or assets.

     8.9  Limitation On Rights of Investors.  The rights of Right Holders other
          ---------------------------------
than the Investors under Section 8.1, and the obligations of the Corporation to
Right Holders other than the Investors under Section 8.1, shall terminate and be
of no effect upon and following the closing of a firm commitment underwritten
public offering of the Corporation's Common Stock pursuant to an effective
registration statement under the Securities Act in which (i) the offering price
per share is not less than $4.50 (prior to underwriter's discounts and
commissions), appropriately adjusted to take account of any stock split, stock
dividend, combination of shares, or the like, and (ii) the aggregate gross
proceeds to the Corporation from such offering are not less than $10 million.
The rights of the Investors under Sections 8.1 through 8.8, inclusive, and the
obligations of the Corporation to Investors under Sections 8.1 through 8.8,
inclusive, shall terminate and be of no effect upon and following the closing of
a firm commitment underwritten public offering of the Corporation's Common Stock
pursuant to an effective registration statement under the Securities Act in
which (i) the offering price per share is not less than $9.45 (prior to
underwriter's discounts and commissions), appropriately adjusted to take account
of any stock split, stock dividend, combination of shares, or the like, and (ii)
the aggregate gross proceeds to the Corporation from such offering are not less
than $20 million.

     8.10  Proprietary Information and Invention Assignment Agreements.  As soon
           -----------------------------------------------------------
as practicable after the Initial Closing, the Corporation will use reasonable
efforts to cause each senior technical employee who has not already signed an
agreement with the Corporation relating to the protection of proprietary
information and the assignment of inventions to sign such an agreement in a form
acceptable to the Board of Directors of the Corporation.

     SECTION 9.  Expenses.
     ---------   --------

     9.1  Expenses.  The Corporation shall pay the reasonable fees and
          --------
disbursements of one or more special counsel to the Investors in connection with
the transactions contemplated by this Agreement, up to a maximum aggregate
amount of $10,000.  Otherwise, the Corporation and the Investors shall each bear
their own expenses, including the fees and disbursements of their respective
counsel, incurred in connection with the purchase and sale of the Shares and the
Warrants.

     9.2  Brokers.  No party to this Agreement has employed any broker or finder
          -------
in connection with the transactions contemplated hereby.  No person or entity
will have, as a result of the transactions contemplated by this Agreement, any
right, interest or valid claim against or upon any such party of any commission,
fee or other compensation as a finder or broker because of any act or omission
by such party or any agent of such party.  Each party to this Agreement agrees
to indemnify and hold the others harmless from payment of any brokerage fee,
finders fee, or commission claimed by any third party who claims to have been
involved because of association with such party.

                                      -18-
<PAGE>

     SECTION 10.  Exchanges; Lost, Stolen or Mutilated Certificates.  Upon
     ----------   -------------------------------------------------
surrender by any Investor to the Corporation of a Warrant or a certificate or
certificates representing shares of Series C Preferred purchased or acquired by
such Investor hereunder or under the Warrants, or representing Reserved Shares
received upon conversion of any such shares of Series C Preferred, the
Corporation at its expense shall issue in exchange therefor, and deliver to such
Investor, a new Warrant or a new certificate or certificates representing such
shares, in such denomination or denominations as may be requested by such
Investor. Upon receipt of evidence satisfactory to the Corporation of the loss,
theft, destruction or mutilation of any Warrant or any certificate representing
any shares of Series C Preferred purchased or acquired by the Investor hereunder
or under the Warrants, or representing Reserved Shares received upon conversion
of any such shares of Series C Preferred and in case of any such loss, theft or
destruction, upon delivery of any indemnity agreement satisfactory to the
Corporation, or in case of any such mutilation, upon surrender and cancellation
of such Warrant or such certificate, the Corporation at its expense shall issue
and deliver to such Investor a new Warrant or a new certificate for such shares
of Series C Preferred or Reserved Shares, of like tenor, in lieu of such lost,
stolen or mutilated certificate.

     SECTION 11.  Survival of Representations, Warranties and Agreements.  The
     ----------   ------------------------------------------------------
covenants, representations and warranties of the parties contained herein shall
survive any Closing hereunder.  Each of the parties may rely on such covenants,
representations and warranties irrespective of any investigation made, or notice
or knowledge held by, it or any other person.  All statements contained in any
certificate or other instrument delivered by any party pursuant to this
Agreement or in connection with the transactions contemplated by this Agreement
shall constitute representations and warranties by such party under this
Agreement.

     SECTION 12.  Remedies.  In case any one or more of the covenants or
     ----------   --------
agreements set forth in this Agreement shall have been breached by the
Corporation, the Investors may proceed to protect and enforce their rights
either by suit in equity or by action at law, including, but not limited to, an
action for damages as a result of any such breach or an action for specific
performance of any such covenant or agreement contained in this Agreement.

     SECTION 13.  Successors and Assigns.  This Agreement shall be binding upon,
     ----------   ----------------------
and inure to the benefit of, each of the parties hereto and, except as otherwise
expressly provided herein, each other person who shall become a registered
holder named in any Warrant or any certificate evidencing shares of Common Stock
or Series C Preferred transferred to such holder by any of the Investors or
their permitted transferees, and (except as aforesaid) their respective legal
representatives, successors and assigns.

     SECTION 14.  Entire Agreement; Effect on Prior Documents.  This Agreement
     ----------   -------------------------------------------
and the other documents referred to herein or delivered pursuant hereto contain
the entire agreement among the parties with respect to the financing
transactions contemplated hereby and supersede all prior negotiations,
commitments, agreements and understandings among them with respect thereto.

     SECTION 15.  Notices.  All notices, requests, consents and other
     ----------   -------
communications hereunder to any party shall be deemed to be sufficient if
contained in a written instrument

                                      -19-
<PAGE>

delivered in person or duly sent by first class mail postage prepaid (other than
to non-U.S. parties) or fax or DHL, Federal Express or other internationally
recognized express courier service, addressed to such party at the address set
forth below or such other address as may hereafter be designated in writing by
the addressee to the addressor listing all parties:

          (i)  if to the Corporation, to:

               Sequenom, Inc.
               11555 Sorrento Valley Road
               Suite C
               San Diego, California 92121
               Attention: President
               Fax: (619) 350-0344

               with a copy to:

               David R. Pierson, Esq.
               Foley, Hoag & Eliot LLP
               One Post office Square
               Boston, Massachusetts 02109
               Fax:  (617) 832-7000

          (ii) if to the Investors, to their respective addresses set forth on
               the Schedule of Investors.
                   ---------------------

     SECTION 16.  Amendments; Waivers.  This Agreement may be amended, and
     ----------   -------------------
compliance with the provisions of this Agreement may be omitted or waived, by
the written agreement of the Corporation and Investors or assignees of their
rights hereunder holding two thirds in voting power of the Series C Preferred
(and Common Stock issued upon conversion thereof) held by the Investors and such
assignees.  Sections 8.1 and 8.9 hereof and this Section 16 may be amended only
with the further written agreement of Series B Investors or assignees of their
rights hereunder holding 85 % of the voting power of the Series B Preferred (or
Common Stock issued upon conversion thereof) held by the Series B Investors or
such assignees.

     SECTION 17.  Counterparts.  This Agreement may be executed in any number of
     ----------   ------------
counterparts, each such counterpart shall be deemed to be an original
instrument, and all such counterparts together shall constitute but one
agreement.  Any such counterpart may contain one or more signature pages.

     SECTION 18.  Headings.  The headings of the various sections of this
     ----------   --------
Agreement have been inserted for convenience of reference only and shall not be
deemed to be a pan of this Agreement.

     SECTION 19.  Nouns and Pronouns.  Whenever the context may require, any
     ----------   ------------------
pronouns used herein shall include the corresponding masculine, feminine or
neuter forms, and the singular form of names and pronouns shall include the
plural and vice-versa.

                                      -20-
<PAGE>

     SECTION 20.  Governing Law.  This Agreement shall be governed by, and
     ----------   -------------
construed and enforced in accordance with, the substantive laws of The
Commonwealth of Massachusetts, without regard to its principles of conflicts of
laws.

     SECTION 21.  Severability.  Any provision of this Agreement that is
     ----------   ------------
prohibited or unenforceable in any jurisdiction shall, as to such jurisdiction,
be ineffective to the extent of such prohibition or unenforceability without
invalidating the remaining provisions hereof, and any such prohibition or
unenforceability in any jurisdiction shall not invalidate or render
unenforceable such provision in any other jurisdiction.

     SECTION 22.  Information Confidential.  Each Investor acknowledges that the
     ----------   ------------------------
information received by it pursuant hereto (including without limitation under
Section 7 hereof) is confidential and for its use only and such Investor will
not reproduce, disclose or disseminate such information to any other person
(other than its employees or agents having a need to know the contents of such
information), except in connection with the exercise of rights under this
Agreement, unless the Corporation has made such information available to the
public generally or such Investor is required to disclose such information by
law or by any court or other governmental body; provided, however, that an
                                                --------
Investor may make general statements concerning the nature and progress of the
Corporation's business and may include summary financial information concerning
the Corporation in such Investor's reports to its partners or shareholders.  The
obligation of confidentiality set forth in this Section shall not apply to
information (i) generally known on a non-confidential basis (without fault of an
Investor) to companies in the Corporation's line of business; (ii) lawfully
obtained by an Investor without restriction on disclosure; (iii) known to an
Investor prior to receipt from the Corporation without restriction on
disclosure; or (iv) independently developed by an Investor without use of
information provided by the Corporation.

                                     * * *

                                      -21-
<PAGE>

     IN WITNESS WHEREOF, the undersigned have executed this Series C Convertible
Preferred Stock Agreement as of the day and year first written above.

                              SEQUENOM, INC.


                              By:  /s/ illegible
                                   ----------------------------------------
                                   Its President

     For purposes of Sections 8.1 and 8.9 only:

                    FOUNDERS:


                              /s/ Hubert Koster
                              ---------------------------------------------
                              Hubert Koster

                              /s/ Nola Masterson
                              ---------------------------------------------
                              Nola E. Masterson

                              /s/ Robert Patterson
                              ---------------------------------------------
                              Robert E. Patterson

                    SERIES B INVESTORS:

                              TVM TECHNO VENTURE
                              ENTERPRISES NO. II
                              LIMITED PARTNERSHIP

                              By:  TVM Techno Venture Management
                                   Limited Partnership
                                     its General Partner
                              By:  TVM Management Corporation
                                     its General Partner

                              By: /s/ illegible
                                  -----------------------------------------
                                    Name:
                                    Title:

                                      -22-
<PAGE>

                              TVM INTERTERTECH LIMITED
                              PARTNERSHIP

                              By:  TVM Techno Venture Management
                                   Limited Partnership
                                     its General Partner
                              By:  TVM Management Corporation
                                     its General Partner



                              By: /s/ illegible
                                  -----------------------------------------
                                  Its:

                              TVM ZWEITE BETEILIGUNG-US
                              LIMITED PARTNERSHIP

                              By:  TVM Techno Venture Management
                                   Limited Partnership
                                     its General Partner
                              By:  TVM Management Corporation
                                     its General Partner


                              By: /s/ illegible
                                  -----------------------------------------
                                  Its:


                                      -23-
<PAGE>

                              TVM EUROTECH LIMITED
                              PARTNERSHIP
                              By:  TVM Techno Venture Management
                                   Limited Partnership
                                     Its General Partner
                              By:  TVM Management Corporation
                                     Its General Partner


                              By: /s/ illegible
                                  -----------------------------------------
                                  Its:


                              TVM TECHNO VENTURE
                              INVESTORS NO. 1 LIMITED
                              PARTNERSHIP


                              By: /s/ illegible
                                  -----------------------------------------
                                  General Partner


                              ***


                              ALPINVEST INTERNATIONAL B. V.


                              By: /s/ illegible         /s/ illegible
                                  ---------------------------------------
                                  Its:  authorized signatories


                              ***
                                      -24-

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                              ***

                              /s/ Hubert Koster
                              ---------------------------------------------
                              Hubert Koster

                              /s/ Ernst-Gunter Afting
                              ---------------------------------------------
                              Ernst-Gunter Afting


                              ***

                                      -25-

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                              ***

                                      -26-

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                 SEQUENOM, INC.

            Series C Convertible Preferred Stock Purchase Agreement


                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i.) that it is an "Investor" as defined in the Series C
Convertible Preferred Stock Purchase Agreement dated as of May 8, 1997 among
Sequenom, Inc. (the "Corporation") and certain investors named on the Schedule
                                                                      --------
of Investors thereto (the "Purchase Agreement"), (ii) that it is a party to the
- ------------
Purchase Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Purchase Agreement.

     EXECUTED this 8th day of May, 1997.

                            TVM TECHNO VENTURE
                            ENTERPRISES NO.  II
                            LIMITED PARTNERSHIP
76,064
- ------------------------
Shares Purchased            By: TVM Techno Venture Management
                                Limited Partnership,
                                its general partner
7,606                       By: TVM Management Corporation
- ------------------------        its general partner
Number of Shares subject
to Warrants Purchased

$239,601.60                 By:  /s/ illegible
- ------------------------    ------------------------------------
Total Purchase Price        Its: Treasurer
<PAGE>

                                 SEQUENOM, INC.

            Series C Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series C
Convertible Preferred Stock Purchase Agreement dated as of May 8, 1997, among
Sequenom, Inc. (the "Corporation") and certain investors named on the Schedule
                                                                      --------
of Investors thereto (the "Purchase Agreement"), (ii) that it is a party to the
- ------------
Purchase Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Purchase Agreement.


     EXECUTED this 8th day of May, 1997.

                                TVM INTERTECH
                                LIMITED PARTNERSHIP

      50,709                    By:  TVM Techno Venture Management
- ------------------------             Limited Partnership,
Shares Purchased                     its general partner

       5,070
- ------------------------
Number of Shares subject        By:  TVM Management Corporation,
to Warrants Purchased                its general partner

      $159,733.35
- ------------------------
Total Purchase Price            By:  /s/ illegible
                                     -------------------------------------
                                Its: Treasurer
<PAGE>

                                 SEQUENOM, INC.

            Series C Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series C
Convertible Preferred Stock Purchase Agreement dated as of May 8, 1997, among
Sequenom, Inc. (the "Corporation") and certain investors named on the Schedule
                                                                      --------
of Investors thereto (the "Purchase Agreement"), (ii) that it is a party to the
- ------------
Purchase Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Purchase Agreement.


     EXECUTED this 8th day of May, 1997.

                                TVM ZWEITE BETEILIGUNG-US
                                LIMITED PARTNERSHIP

   152,127                      By:  TVM Techno Venture Management
- -----------------------              Limited Partnership,
Shares Purchased                     its general partner

   15,212
- -----------------------
Number of Shares subject        By:  TVM Management Corporation,
to Warrants Purchased                its general partner

   $479,200.15
- -----------------------
Total Purchase Price            By:  /s/ illegible
                                  ---------------
                                Its:  Treasurer
<PAGE>

                                SEQUENOM, INC.

            Series C Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series C
Convertible Preferred Stock Purchase Agreement dated as of May 8, 1997, among
Sequenom, Inc. (the "Corporation") and certain investors named on the Schedule
                                                                      --------
of Investors thereto (the "Purchase Agreement"), (ii) that it is a party to the
- ------------
Purchase Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Purchase Agreement.


     EXECUTED this 8th day of May, 1997.

                                TVM EUROTECH
                                LIMITED PARTNERSHIP

   101,418                      By:  TVM Techno Venture Management
 -----------------------             Limited Partnership,
Shares Purchased                     its general partner

 10,141
- ------------------------
Number of Shares subject        By:  TVM Management Corporation,
to Warrants Purchased                its general partner

$319,466.70
- ------------------------
Total Purchase Price            By:  /s/ illegible
                                     ----------------------------------
                                Its: Treasurer
<PAGE>

                                SEQUENOM, INC.

            Series C Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series C
Convertible Preferred Stock Purchase Agreement dated as of May 8, 1997, among
Sequenom, Inc. (the "Corporation") and certain investors named on the Schedule
                                                                      --------
of Investors thereto (the "Purchase Agreement"), (ii) that it is a party to the
- ------------
Purchase Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Purchase Agreement.


     EXECUTED this 8th day of May, 1997.

                                TVM TECHNO VENTURE
                                INVESTORS NO. 1
                                LIMITED PARTNERSHIP

  8,253                         By:  TVM Techno Venture Management
- -------------------------            Limited Partnership,
Shares Purchased                     its general partner

   825
- -------------------------
Number of Shares subject        By:  TVM Management Corporation,
to Warrants Purchased                its general partner

 $25,996.95
- -------------------------
Total Purchase Price            By:  /s/ illegible
                                     -------------------------------------
                                Its:
<PAGE>

                                SEQUENOM, INC.

            Series C Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series C
Convertible Preferred Stock Purchase Agreement dated as of May 8, 1997, among
Sequenom, Inc. (the "Corporation") and certain investors named on the Schedule
                                                                      --------
of Investors thereto (the "Purchase Agreement"), (ii) that it is a party to the
- ------------
Purchase Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Purchase Agreement.


     EXECUTED this 8th day of May, 1997.


                              ***
                              ---------------------------------------
                              (print name)

_____________________
Shares Purchases              By:  ***
                                   ----------------------------------


_____________________         Title:   ***
Number of Shares subject           ----------------------------------
Director                               ***
to Warrants Purchases


                              Address:_______________________________
_____________________
Total Purchase Price          ______________________________________

                              ______________________________________

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                 SEQUENOM, INC.

            Series C Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series C
Convertible Preferred Stock Purchase Agreement dated as of May 8, 1997, among
Sequenom, Inc. (the "Corporation") and certain investors named on the Schedule
                                                                      --------
of Investors thereto (the "Purchase Agreement"), (ii) that it is a party to the
- ------------
Purchase Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Purchase Agreement.


     EXECUTED this 8th day of May, 1997.


                              ALPINVEST INTERNATIONAL B.V.
                              ----------------------------
                              (print name)


    317,460                     By:  /s/ J.M. Davids        /s/ J.H.M. Dols
- ------------------------             -----------------------------------------
Shares Purchases

    31,746                      Title: authorized signatories
- ------------------------               ---------------------------------------
Number of Shares subject
to Warrants Purchases

                                Address:  Gooimeer 3
                                          ------------------------------------
   USD 999,999                            1411 DC NAARDEN
 --------------                 ----------------------------------------------
Total Purchase Price                      The Netherlands
                                ----------------------------------------------


<PAGE>

                                 SEQUENOM, INC.

            Series C Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series C
Convertible Preferred Stock Purchase Agreement dated as of May 8, 1997, among
Sequenom, Inc. (the "Corporation") and certain investors named on the Schedule
                                                                      --------
of Investors thereto (the "Purchase Agreement"), (ii) that it is a party to the
- ------------
Purchase Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Purchase Agreement.


     EXECUTED this 8th day of May, 1997.


                              ***
                              ----------------
                              (print name)

    15,873
- ----------------------
Shares Purchases              By: ***
                                  -------------------------------------

    1,587                     Title:
- ----------------------              -----------------------------------
Number of Shares subject
to Warrants Purchases

                              Address:  ***
                                        -------------------------------
   USD 50,000.00                        ***
 ---------------              -----------------------------------------
Total Purchase Price
                              -----------------------------------------

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                 SEQUENOM, INC.

            Series C Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series C
Convertible Preferred Stock Purchase Agreement dated as of May 8, 1997, among
Sequenom, Inc. (the "Corporation") and certain investors named on the Schedule
                                                                      --------
of Investors thereto (the "Purchase Agreement"), (ii) that it is a party to the
- ------------
Purchase Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Purchase Agreement.


     EXECUTED this 8th day of May, 1997.


                              ***
                              --------------------------------------------
                              (print name)

    222,222
- -----------------------
Shares Purchases              By: ***
                                  ----------------------------------------

    22,222                    Title:
- -----------------------             --------------------------------------
Number of Shares subject
to Warrants Purchases

    USD 700,000.00            Address:  ***
- -----------------------               ------------------------------------
Total Purchase Price                    ***
                              --------------------------------------------

                              --------------------------------------------

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                 SEQUENOM, INC.

            Series C Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series C
Convertible Preferred Stock Purchase Agreement dated as of May 8, 1997, among
Sequenom, Inc. (the "Corporation") and certain investors named on the Schedule
                                                                      --------
of Investors thereto (the "Purchase Agreement"), (ii) that it is a party to the
- ------------
Purchase Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Purchase Agreement.


     EXECUTED this 8th day of May, 1997.


                              ***
                              -----------
                              (print name)

    16,667
- ------------------------
Shares Purchases              By: ***
                                  ----------------------------------------

    1,666                     Title:
- ------------------------
Number of Shares subject
to Warrants Purchases

                              Address:  ***
                                        ----------------------------------
    $52,501.05                           ***
- -------------------------     --------------------------------------------
Total Purchase Price                     ***
                              --------------------------------------------

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                 SEQUENOM, INC.

            Series C Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series C
Convertible Preferred Stock Purchase Agreement dated as of May 8, 1997, among
Sequenom, Inc. (the "Corporation") and certain investors named on the Schedule
                                                                      --------
of Investors thereto (the "Purchase Agreement"), (ii) that it is a party to the
- ------------
Purchase Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Purchase Agreement.


     EXECUTED this 8th day of May, 1997.


                              ***
                              ----------------
                              (print name)

    16,667
- ------------------------
Shares Purchases              By: ***
                                  --------------------------------------

    1,666                     Title:
- ------------------------            ------------------------------------
Number of Shares subject
to Warrants Purchases

                              Address:   ***
                                         -------------------------------
      $52,501.05                          ***
- ------------------------      ------------------------------------------
Total Purchase Price                      ***
                              ------------------------------------------

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                 SEQUENOM, INC.

            Series C Convertible Preferred Stock Purchase Agreement

                       Additional Investor Signature Page
                       ----------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series C
Convertible Preferred Stock Purchase Agreement dated as of May 8, 1997, among
Sequenom, Inc. (the "Corporation") and certain investors named on the Schedule
                                                                      --------
of Investors thereto (the "Purchase Agreement"), (ii) that it is a party to the
- ------------
Purchase Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
                                           ---------------------
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series C Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.


     EXECUTED this 15th day of December, 1997.

                              ***

                              ---------------------------------------------
                              (print name)


                              By: ***
                                  -----------------------------------------

       By:  ***

                              By: ***
                                  -----------------------------------------

                              Address:   ***
                                       ------------------------------------
                                         ***
                              ---------------------------------------------
                                         ***
                              ---------------------------------------------

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                 SEQUENOM, INC.

            Series C Convertible Preferred Stock Purchase Agreement

                       Additional Investor Signature Page
                       ----------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series C
Convertible Preferred Stock Purchase Agreement dated as of May 8, 1997, among
Sequenom, Inc. (the "Corporation") and certain investors named on the Schedule
                                                                      --------
of Investors thereto (the "Purchase Agreement"), (ii) that it is a party to the
- ------------
Purchase Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
                                           ---------------------
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series C Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.


     EXECUTED this 15th day of December, 1997.

                              ***

                              ---------------------------------------------
                              (print name)


                              By: ***
                                  -----------------------------------------

        By: ***

                              By: ***
                                  -----------------------------------------

                              Address:   ***
                                       ------------------------------------
                                         ***
                              ---------------------------------------------
                                         ***
                              ---------------------------------------------

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                 SEQUENOM, INC.

            Series C Convertible Preferred Stock Purchase Agreement

                       Additional Investor Signature Page
                       ----------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series C
Convertible Preferred Stock Purchase Agreement dated as of May 8, 1997, among
Sequenom, Inc. (the "Corporation") and certain investors named on the Schedule
                                                                      --------
of Investors thereto (the "Purchase Agreement"), (ii) that it is a party to the
- ------------
Purchase Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
                                           ---------------------
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series C Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.


     EXECUTED this 15th day of December, 1997.

                              ***

                              --------------------------------------------
                              (print name)


                              By: ***
                                  --------------

        By: ***

                              By: ***
                                  ----------------------------------------

                              Address:  ***
                                        ----------------------------------
                                        ***
                              --------------------------------------------
                                        ***
                              --------------------------------------------

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                 SEQUENOM, INC.

            Series C Convertible Preferred Stock Purchase Agreement

                       Additional Investor Signature Page
                       ----------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series C
Convertible Preferred Stock Purchase Agreement dated as of May 8, 1997, among
Sequenom, Inc. (the "Corporation") and certain investors named on the Schedule
                                                                      --------
of Investors thereto (the "Purchase Agreement"), (ii) that it is a party to the
- ------------
Purchase Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
                                           ---------------------
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series C Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.


     EXECUTED this 16th day of December, 1997.

                              ***
                              ---------------------------------------------
                              (print name)


                              By: ***
                                  -----------------------------------------
                                  ***

                              Title:  ***
                                      -------------------------------------

                              Address:   ***
                                       ------------------------------------
                                         ***
                              ---------------------------------------------

                              ---------------------------------------------

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                 SEQUENOM, INC.

            Series C Convertible Preferred Stock Purchase Agreement

                       Additional Investor Signature Page
                       ----------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series C
Convertible Preferred Stock Purchase Agreement dated as of May 8, 1997, among
Sequenom, Inc. (the "Corporation") and certain investors named on the Schedule
                                                                      --------
of Investors thereto (the "Purchase Agreement"), (ii) that it is a party to the
- ------------
Purchase Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
                                           ---------------------
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series C Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.


     EXECUTED this 17th day of December, 1997.

                              ***

                              ***
                              -------------------------------------------
                              (print name)


                              By: ***
                                  ---------------------------------------

                              Title:  ***
                                      -----------------------------------

                              Address:   ***
                                         --------------------------------
                                        ***
                              -------------------------------------------
                                      ***
                              -------------------------------------------

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                 SEQUENOM, INC.

            Series C Convertible Preferred Stock Purchase Agreement

                       Additional Investor Signature Page
                       ----------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series C
Convertible Preferred Stock Purchase Agreement dated as of May 8, 1997, among
Sequenom, Inc. (the "Corporation") and certain investors named on the Schedule
                                                                      --------
of Investors thereto (the "Purchase Agreement"), (ii) that it is a party to the
- ------------
Purchase Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
                                           ---------------------
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series C Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.


     EXECUTED this 8th day of January, 1998.

                              ***


                              -------------------------------------------
                              (print name)


                              By: ***
                                  ---------------------------------------
                                  ***

                              Title: ***

                              Address:   ***
                                         --------------------------------
                                         ***
                              -------------------------------------------
                                         ***
                              -------------------------------------------

With copies of all correspondence to:
- ------------------------------------

***

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                 SEQUENOM, INC.

            Series C Convertible Preferred Stock Purchase Agreement

                       Additional Investor Signature Page
                       ----------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series C
Convertible Preferred Stock Purchase Agreement dated as of May 8, 1997, among
Sequenom, Inc. (the "Corporation") and certain investors named on the Schedule
                                                                      --------
of Investors thereto (the "Purchase Agreement"), (ii) that it is a party to the
- ------------
Purchase Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
                                           ---------------------
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series C Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.


     EXECUTED this 8th day of January, 1998.

                              LOMBARD ODIER 4 CIE
                              ---------------------------------------------
                              (print name) par procuration:


                              By: /s/ illegible
                                  -----------------------------------------

                              Title:  Vice-President          Assistant V.P.
                                    ----------------------------------------


                              Address:   11 Rue de la Corraterie
                                       -------------------------------------
                                        CH-1204 Geneva Switzerland
                              ----------------------------------------------

                              ----------------------------------------------
<PAGE>

                                 SEQUENOM, INC.

            Series C Convertible Preferred Stock Purchase Agreement

                       Additional Investor Signature Page
                       ----------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series C
Convertible Preferred Stock Purchase Agreement dated as of May 8, 1997, among
Sequenom, Inc. (the "Corporation") and certain investors named on the Schedule
                                                                      --------
of Investors thereto (the "Purchase Agreement"), (ii) that it is a party to the
- ------------
Purchase Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Purchase Agreement.

     Attached hereto is an addendum to the Schedule of Investors to the Purchase
                                           ---------------------
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series C Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.


     EXECUTED this 8th day of January, 1998.

                              ***
                              ---------------------------------------------
                              (print name)


                              By: ***
                                  -----------------------------------------
                                  ***

                              Title:  ***
                                    ---------------------------------------

                              Address:   ***
                                       ------------------------------------
                                        ***
                              ---------------------------------------------
                                        ***
                              ---------------------------------------------
                                        ***
                                        ***


With copies to:  ***
- --------------

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                             SCHEDULE OF INVESTORS


<TABLE>
<CAPTION>
                                                      Number of Shares of
                                                      Series C Preferred        Number of Shares      Aggregate Purchase
Initial Investor                                            Stock              Subject to Warrant            Price
_________________________________________________     ___________________      __________________    ___________________
<S>                                                   <C>                      <C>                   <C>
TVM Techno Venture                                                 76,064                   7,606         $  239,601.60
 Enterprises No. 11
 Limited Partnership
c/o TVM Techno Venture
 Management ("TVM")
 101 Arch Street, Suite 1950
 Boston, MA 02210
TVM Intertech                                                      50,709                   5,070         $  159,733.35
 Limited Partnership
c/o TVM
TVM Zweite Beteiligung-US                                         152,127                  15,212         $  479,200.05
 Limited Partnership
 c/o TVM
TVM Eurotech Limited                                              101,418                  10,141         $  319,466.70
 Partnership
c/o TVM
TVM Techno Venture                                                  8,253                     825         $   25,996.95
 Investors No. 1
 Limited Partnership
c/o TVM
***                                                                87,619                   8,761         $  275,999.85
Alpinvest International B.V.                                      317,460                  31,746         $  999,999.00
Gooimeer 3
NL-1410 AB Naarden
The Netherlands
***                                                                15,873                   1,587         $   49,999.95

***                                                               222,222                  22,222         $  699,999.30
***                                                                16,667                   1,666         $   52,501.05

***                                                                16,667                   1,666         $   52,501.05

TOTAL                                                           1,065,079                 106,502         $3,354,998.85
</TABLE>
***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                     TO THE
                         SERIES C CONVERTIBLE PREFERRED
                            STOCK PURCHASE AGREEMENT
                            DATED AS OF MAY 8, 1997

<TABLE>
<CAPTION>

                       Number of Shares of Series C
Investor               Preferred Stock                Aggregate Purchase Price
- --------------------   -----------------------------  -------------------------
<S>                    <C>                            <C>
   ***                           -68,762-                    USD216,600-
</TABLE>




    ***
- --------------------------------------
Print Name of Investor

By /s/ illegible
  ------------------------------------
     By:  ***
     By:  ***

Date:  December 15, 1997
     ---------------------------------

Accepted and agreed to this
12 day of  January    , 1998
- --        -------------


SEQUENOM, INC.


By:  /s/ Hubert Koster
   -----------------------------------
 Its:  President


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                     TO THE
                         SERIES C CONVERTIBLE PREFERRED
                            STOCK PURCHASE AGREEMENT
                            DATED AS OF MAY 8, 1997

<TABLE>
<CAPTION>
                         Number of Shares of Series C
Investor                 Preferred Stock                Aggregate Purchase Price
- ---------------------    ----------------------------   ------------------------
<S>                      <C>                            <C>
   ***                             -13,047                      USD41,100.-
</TABLE>


   ***
- ----------------------------------------
Print Name of Investor


By /s/ illegible
  --------------------------------------
     By:  ***
     By:  ***

Date:  December 15, 1997
       ---------------------------------

Accepted and agreed to this
12th day of January, 1998
- ----        -------


SEQUENOM, INC.


By:  /s/ Hubert Koster
   -------------------
 Its:  President

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                     TO THE
                         SERIES C CONVERTIBLE PREFERRED
                            STOCK PURCHASE AGREEMENT
                            DATED AS OF MAY 8, 1997

<TABLE>
<CAPTION>
                   Number of Shares of Series C
Investor           Preferred Stock                    Aggregate Purchase Price
- ----------------   ----------------------------       ------------------------
<S>                <C>                                <C>
   ***                       -156,286-                        USD492,300.-
</TABLE>


   ***
- -----------------------------------
Print Name of Investor


By /s/ illegible
  ---------------------------------
     By:  ***
     By:  ***

Date:  December 15, 1997
       ----------------------------

Accepted and agreed to this
12th day of January, 1998
- ----        -------


SEQUENOM, INC.


By:  /s/ Hubert Koster
   ---------------------------------
 Its:  President

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                     TO THE
                         SERIES C CONVERTIBLE PREFERRED
                            STOCK PURCHASE AGREEMENT
                            DATED AS OF MAY 8, 1997

<TABLE>
<CAPTION>
                     Number of Shares of Series C
Investor             Preferred Stock                  Aggregate Purchase Price
- -------------------- ------------------------------   ------------------------
<S>                  <C>                              <C>
  ***                           507,936                     $1,599,998.40
</TABLE>



  ***
- --------------------------------------
Print Name of Investor


By  /s/ illegible
  ------------------------------------
     Its:  Vice President

Date:  December 16, 1997
       -------------------------------

Accepted and agreed to this
12th day of January, 1998
- ----        -------


SEQUENOM, INC.


By:  /s/ Hubert Koster
     ---------------------------------
 Its:  President


*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                     TO THE
                         SERIES C CONVERTIBLE PREFERRED
                            STOCK PURCHASE AGREEMENT
                            DATED AS OF MAY 8, 1997

<TABLE>
<CAPTION>
                     Number of Shares of Series C
Investor             Preferred Stock                 Aggregate Purchase Price
- -------------------- -----------------------------   ---------------------------
<S>                  <C>                             <C>
                              793,650                        $2,500,000
</TABLE>



       ***
- -----------------------------------
Print Name of Investor


By  /s/ illegible
  ---------------------------------
 Its:  Director

Date:  17 December 1997
       ----------------------------

Accepted and agreed to this
12th day of January, 1998
- ----        -------


SEQUENOM, INC.


By:  /s/ Hubert Koster
   --------------------------------
 Its:


    *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                     TO THE
                         SERIES C CONVERTIBLE PREFERRED
                            STOCK PURCHASE AGREEMENT
                            DATED AS OF MAY 8, 1997

<TABLE>
<CAPTION>
                     Number of Shares of Series C
Investor             Preferred Stock                Aggregate Purchase Price
- -------------------  ----------------------------   ------------------------
<S>                  <C>                            <C>
                                317,460                     1,000,000
</TABLE>



   ***
- --------------------------------------
Print Name of Investor


By  /s/ illegible
  ------------------------------------
     Its:  Managing Partner

Date:  8 January 1998
    ----------------------------------

Accepted and agreed to this
12th day of January, 1998
- ----        -------


SEQUENOM, INC.


By:  /s/ Hubert Koster
   -----------------------------------
 Its:

    *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                     TO THE
                         SERIES C CONVERTIBLE PREFERRED
                            STOCK PURCHASE AGREEMENT
                            DATED AS OF MAY 8, 1997

<TABLE>
<CAPTION>
                      Number of Shares of Series C
Investor              Preferred Stock                   Aggregate Purchase Price
- --------------------- -----------------------------     ------------------------
<S>                   <C>                               <C>
      ***                       952,381                        $3,000,000
</TABLE>

      ***
- ----------------------------------------
Print Name of Investor


By  /s/ illegible         /s/ illegible
  --------------------------------------
    Vice-Pres.            Assistant V.P.

Date:  January 8, 1998
       ---------------------------------

Accepted and agreed to this
12th day of January, 1998
- ----        -------


SEQUENOM, INC.


By:  /s/ Hubert Koster
   -------------------------------------
 Its:  President



    *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                     TO THE
                         SERIES C CONVERTIBLE PREFERRED
                            STOCK PURCHASE AGREEMENT
                            DATED AS OF MAY 8, 1997

<TABLE>
<CAPTION>
                     Number of Shares of Series C
Investor             Preferred Stock                   Aggregate Purchase Price
- -------------------- -----------------------------     ------------------------
<S>                  <C>                               <C>
                                158,730                         500,000
</TABLE>



     ***
- -------------------------------------
Print Name of Investor


By  /s/ illegible
    ---------------------------------
        Its:  Attorney-in-fact

Date:  8 January 1998
       ------------------------------

Accepted and agreed to this
12th day of January, 1998
- ----        -------


SEQUENOM, INC.


By:  /s/ Hubert Koster
   ----------------------------------
 Its:

   *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                   EXHIBIT 1
                                   ---------


                            Certificate of Amendment
                            ------------------------

<PAGE>

                            CERTIFICATE OF AMENDMENT
                                       OF
                          CERTIFICATE OF INCORPORATION
                               OF SEQUENOM, INC.

     Sequenom, Inc., a corporation organized and existing under and by virtue of
the General Corporation Law of the State of Delaware, DOES HEREBY CERTIFY:

FIRST:    That at a meeting of the Board of Directors of said corporation
          resolutions were duly adopted proposing and declaring advisable that
          the Certificate of Incorporation of said corporation be amended and
          that such amendment be submitted to the stockholders of the
          Corporation for their consideration, as follows:

     RESOLVED:  That the Board of Directors of this Corporation recommends and
                deems it advisable that the Certificate of Incorporation of this
                Corporation, as heretofore amended, be further amended by
                deleting Article FOURTH thereof and substituting for said
                Article FOURTH the new Article FOURTH set forth on Exhibit A
                                                                   ---------
                attached hereto; and

     RESOLVED:  That the aforesaid proposed amendment be submitted to the
                stockholders of the Corporation for their consideration; and

     RESOLVED:  That following the approval by the stockholders of the aforesaid
                amendment as required by law, the officers of this Corporation
                be, and they hereby are, and each of them hereby is, authorized
                and directed (i) to prepare, execute and file with the Secretary
                of State of the State of Delaware a Certificate of Amendment
                setting forth the aforesaid amendment in the form approved by
                the stockholders and (ii) to take any and all other actions
                necessary, desirable or convenient to give effect to the
                aforesaid amendment or otherwise to carry out the purposes of
                the foregoing Resolutions.

SECOND:   That in lieu of a meeting and vote of stockholders, the stockholders
          have given written consent to said amendments in accordance with the
          provisions of section 228 of the General Corporation Law of the State
          of Delaware, and written notice of the adoption of the amendments has
          been given as provided in section 228 of the General Corporation Law
          of the State of Delaware to every stockholder entitled to such notice.

THIRD:    That the aforesaid amendments were duly adopted in accordance with the
          applicable provisions of sections 228 and 242 of the General
          Corporation Law of the State of Delaware.
<PAGE>

     IN WITNESS WHEREOF, said Sequenom, Inc. has caused this certificate to be
signed by Fareed Kureshy, its President, and attested by David R. Pierson, its
Secretary, this 8th day of May, 1997.

<TABLE>
<CAPTION>

ATTEST:                                  SEQUENOM, INC.
<S>                                      <C>


By:  /s/ David Pierson                   By:  /s/ Fareed Kureshy
   ______________________                   _______________________
         Its Secretary                            Its President
</TABLE>




                                      -2-
<PAGE>

                                   EXHIBIT A
                                   ---------


FOURTH:  The total number of shares of all classes of stock which the
- ------
Corporation has authority to issue is 17,209,774 shares, consisting of 9,218,000
shares of Common Stock, par value $.001 per share (the "Common Stock"),
1,650,000 shares of Series A Convertible Preferred Stock, par value $.001 per
share (the "Series A Preferred Stock"), 2,976,663 shares of Series B Convertible
Preferred Stock, par value $.001 per share  (the "Series B Preferred Stock") and
3,3651,081 shares of Series C Convertible Preferred Stock, par value $.001 per
share (the "Series C Preferred Stock", and, together with the Series A Preferred
Stock and the Series B Preferred Stock, the "Preferred Stock"), amounting to an
aggregate par value of $17,209,774.

     The powers, preferences and rights, and the qualifications, limitations or
restrictions thereof, in respect of each class or series of stock of the
Corporation shall be as follows:

     Section 1.   Liquidation Rights.
     ---------    ------------------

            (a)   Liquidation Payments.
                  --------------------

                  (i)  In the event of any liquidation, dissolution or winding
up of the affairs of the Corporation, whether voluntary or involuntary, the
holders of shares of the Series C Preferred Stock and the Series B Preferred
Stock shall be entitled to be paid first out of the assets of the Corporation
available for distribution to holders of the Corporation's capital stock of all
classes the following amounts:

                       (1)  in the case of the- Series C Preferred Stock, an
amount equal to the greater of:

                            (A)  $3.15 per share of the Series C Preferred Stock
(which amount shall be subject to equitable adjustment whenever there shall
occur a stock dividend, stock split, combination of shares, reclassification or
other similar event with respect to the Series C Preferred Stock) plus all
dividends declared but unpaid thereon, to and including the date full payment
shall be tendered to the holders of the Series C Preferred Stock with respect to
such liquidation, dissolution or winding up, or

                            (B)  such amount per share of the Series C Preferred
Stock as would have been payable had all shares of Preferred Stock been
converted to Common Stock immediately prior to such event of liquidation,
dissolution or winding up pursuant to the provisions of Section 2 hereof, plus
all dividends declared but unpaid on each share of the Series C Preferred Stock
to and including the date full payment shall be tendered to the holders of the
Series C Preferred Stock with respect to such liquidation, dissolution or
winding up.

                       (2)  in the case of the Series B Preferred Stock, an
amount equal to the greater of:
<PAGE>

                            (A)  $1.50 per share of the Series B Preferred Stock
(which amount shall be subject to equitable adjustment whenever there shall
occur a stock dividend, stock split, combination of shares, reclassification or
other similar event with respect to the Series B Preferred stock) plus all
dividends declared but unpaid thereon, to and including the date full payment
shall be tendered to the holders of the Series B Preferred Stock with respect to
such liquidation, dissolution or winding up, or

                            (B)  such amount per share of the Series B Preferred
Stock as would have been payable had all shares of Preferred Stock been
converted to Common Stock immediately prior to such event of liquidation,
dissolution or winding up pursuant to the provisions of Section 2 hereof, plus
all dividends declared but unpaid on each share of the Series B Preferred Stock
to and including the date full payment shall be tendered to the holders of the
Series B Preferred Stock with respect to such liquidation, dissolution or
winding up.

     If the assets of the Corporation shall be insufficient to permit the
payment in full to the holders of the Series C Preferred Stock and the Series B
Preferred Stock of all amounts so distributable to them, then the entire assets
of the Corporation available for such distribution shall be distributed ratably
among the holders of the Series C Preferred Stock and the Series B Preferred
Stock in proportion to the full preferential amount each such holder is
otherwise entitled to receive under this Subsection l(a)(i).

                  (ii)  After such payments shall have been made in full to the
holders of the Series C Preferred Stock and the Series B Preferred Stock or
funds necessary for such payments shall have been set aside by the Corporation
in trust for the account of holders of the Series C Preferred Stock and the
Series B Preferred Stock so as to be available for such payments, the holders of
shares of the Series A Preferred Stock shall be entitled to be paid out of the
assets of the Corporation available for distribution to holders of the
Corporation's capital stock of all classes an amount equal to the greater of:

                        (1)  $0.50 per share of the Series A Preferred Stock
(which amount shall be subject to equitable adjustment whenever there shall
occur a stock dividend, stock split, combination of shares, reclassification or
other similar event with respect to the Series A Preferred Stock) plus all
dividends declared but unpaid thereon, to and including the date full payment
shall be tendered to the holders of the Series A Preferred Stock with respect to
such liquidation, dissolution or winding up, or

                        (2)  such amount per share of the Series A Preferred
Stock as would have been payable had all shares of the Preferred Stock been
converted to Common Stock immediately prior to such event of liquidation,
dissolution or winding up pursuant to the provisions of Section 2 hereof, plus
all dividends declared but unpaid on each share of the Series A Preferred Stock
to and including the date full payment shall be tendered to the holders of the
Series A Preferred Stock with respect to such liquidation, dissolution or
winding up.

     If the assets of the Corporation shall be insufficient to permit the
payment in full to the holders of the Series A Preferred Stock of all amounts so
distributable to them, then the entire remaining assets of the Corporation
available for such distribution shall be distributed ratably

                                      -2-
<PAGE>

among the holders of the Series A Preferred Stock in proportion to the full
preferential amount each such holder is otherwise entitled to receive under this
Subsection 1(a)(ii).

                  (iii)  After such payments shall have been made in full to the
holders of the Preferred Stock, or funds necessary for such payments shall have
been set aside by the Corporation in trust for the account of holders of
Preferred Stock so as to be available for such payments, the remaining assets
available for distribution shall be distributed among the holders of the Common
Stock ratably in proportion to the number of shares of Common Stock held by
them.

                  (iv)  Upon conversion of shares of Preferred Stock into shares
of Common Stock pursuant to Section 2 below, the holders of such Common Stock
shall not be entitled to any preferential payment or distribution in case of any
liquidation, dissolution or winding up, but shall share ratably in any
distribution of the assets of the Corporation to all the holders of Common
Stock.

                  (v)  The amounts payable with respect to shares of Preferred
Stock under this Subsection l(a) are sometimes hereinafter referred to as
"Series C Liquidation Payments", "Series B Liquidation Payments" and "Series A
Liquidation Payments", respectively, and together are sometimes hereinafter
referred to as the "Liquidation Payments".

             (b)  Distributions Other than Cash.  Whenever the distributions
                  -----------------------------
provided for in this Section 1 shall be payable in property other than cash, the
value of such distributions shall be the fair market value of such property as
determined in good faith by the Board of Directors of the Corporation.

             (c)  Merger as Liquidation, etc.  The merger or consolidation of
                  --------------------------
the Corporation into or with another corporation (except one in which the
holders of capital stock of the Corporation immediately prior to such merger or
consolidation continue to hold at least eighty percent (80%) in voting power of
the capital stock of the surviving corporation, in which case the provisions of
Subsection 2(h) shall apply), or the sale of all or substantially all of the
assets of the Corporation, shall be deemed to be a liquidation, dissolution or
winding up of the affairs of the Corporation for purposes of this Section 1 (i)
with respect to the Series C Preferred Stock, unless the holders of at least
two-thirds of the then outstanding shares of the Series C Preferred Stock elect
to the contrary, (ii) with respect to the Series B Preferred Stock, unless the
holders of at least eighty-five percent (85%) of the then outstanding shares of
the Series B Preferred Stock elect to the contrary, and (iii) with respect to
the Series A Preferred Stock, unless the holders of at least eighty percent
(80%) of the then outstanding shares of the Series A Preferred Stock elect to
the contrary, such election in each such case to be deemed made upon receipt of
notice thereof by the Corporation at least three days before the effective date
of such event. If such notice is given with respect to any series of Preferred
Stock, the provisions of Subsection 2(h) shall apply to such series of Preferred
Stock. Unless such election is made, any amounts received by the holders of the
Preferred Stock as a result of such merger or consolidation shall be deemed to
be applied toward, and all consideration received by the Corporation in such
asset sale together with all other available assets of the Corporation shall be

                                      -3-
<PAGE>

distributed toward, the Liquidation Payments attributable to such shares of
Preferred Stock in the order of preference set forth in Subsection 1(a).

          (d)  Notice.  Notice of any proposed liquidation, dissolution or
               ------
winding up of the affairs of the Corporation (including any merger,
consolidation or sale of assets which may be deemed to be a liquidation,
dissolution or winding up of the affairs of the Corporation under Subsection 1
(c)), stating a payment date, the amount of the Liquidation Payments and the
place where said Liquidation Payments shall be payable, shall be sent to the
holders of record of the Preferred Stock not less than twenty (20) days prior to
the payment date stated therein.  Any holder of outstanding shares of Preferred
Stock may waive any notice required by this Subsection by a written document
specifically indicating such waiver.

     Section 2.  Conversion.  The holders of Preferred Stock shall have
     ---------   ----------
conversion rights as follows (the "Conversion Rights"):

          (a)  Right to Convert; Conversion Price. Each share of Preferred Stock
               ----------------------------------
shall be convertible, without the payment of any additional consideration by the
holder thereof and at the option of the holder thereof, at any time after the
date of issuance of such share, at the office of the Corporation or any transfer
agent for the Preferred Stock, into such number of fully paid and nonassessable
shares of Common Stock as is determined in accordance with the following:

               (i)  in the case of the Series C Preferred Stock, by dividing
$3.15 by the Series C Conversion Price, determined as hereinafter provided, in
effect at the time of conversion. The Conversion Price at which shares of Common
Stock shall be deliverable upon conversion of the Series C Preferred Stock
without the payment of any additional consideration by the holder thereof (the
"Series C Conversion Price") shall initially be $3.15 per share of Common Stock.
Such initial Series C Conversion Price shall be subject to adjustment, in order
to adjust the number of shares of Common Stock into which the Series C Preferred
Stock is convertible, as hereinafter provided.

               (ii)  in the case of the Series B Preferred Stock, by dividing
$1.50 by the Series B Conversion Price, determined as hereinafter provided, in
effect at the time of conversion. The Conversion Price at which shares of Common
Stock shall be deliverable upon conversion of the Series B Preferred Stock
without the payment of any additional consideration by the holder thereof (the
"Series B Conversion Price") shall initially be $1.50 per share of Common Stock.
Such initial Series B Conversion Price shall be subject to adjustment, in order
to adjust the number of shares of Common Stock into which the Series B Preferred
Stock is convertible, as hereinafter provided.

               (iii)  in the case of the Series A Preferred Stock, by dividing
$0.50 by the Series A Conversion Price, determined as hereinafter provided, in
effect at the time of conversion. The Conversion Price at which shares of Common
Stock shall be deliverable upon conversion of the Series A Preferred Stock
without the payment of any additional consideration by the holder thereof (the
"Series A Conversion Price") shall initially be $0.50 per shares of Common
Stock. Such initial Series A Conversion Price shall be subject to adjustment, in
order

                                      -4-
<PAGE>

to adjust the number of shares of Common Stock into which the Series A Preferred
Stock is convertible, as hereinafter provided.

          (b)  Automatic Conversion.  Each share of Preferred Stock shall
               --------------------
automatically be converted into shares of Common Stock at the applicable
Conversion Price for its series then  in effect upon:

               (i)  the closing of a firm commitment underwritten public
offering pursuant to an effective registration statement under the Securities
Act of 1933, as amended, covering the offer and sale of Common Stock for the
account of the Corporation to the public at an offering price per share (prior
to underwriter commissions and discounts) of not less than (1) in the case of
the Series C Preferred Stock, $9.45, (2) in the case of the Series B Preferred
Stock, $4.50, and (3) in the case of the Series A Preferred Stock, $2.50 (in
each case as adjusted pursuant to Subsection 2(e)(vi) hereof to reflect any
stock dividends, distributions, combinations, reclassifications or other like
transactions effected by the Corporation in respect of its Common Stock) and
with gross proceeds to the Corporation of not less than (1) $20,000,000 in the
case of the Series C Preferred Stock and (2) $10,000,000 in the case of either
the Series B Preferred Stock or the Series A Preferred Stock (in the event of
which offering, the person(s) entitled to receive the Common Stock issuable upon
such conversion of the Preferred Stock shall not be deemed to have converted
that Preferred Stock until the closing of such offering); or

               (ii) (1) in the case of the Series C Preferred Stock, the written
election of the holders of not less than two-thirds, (2) in the case of the
Series B Preferred Stock, the written election of the holders of not less than
eighty-five percent (85 %), and (3) in the case of the Series A Preferred Stock,
the written election of the holders of not less than eighty percent (80%), of
the then outstanding shares of the applicable series of Preferred Stock to
require such mandatory conversion.

          (c)  Mechanics of Optional Conversions.  Before any holder of
               ---------------------------------
Preferred Stock shall be entitled to convert the same into shares of Common
Stock, the holder shall surrender the certificate or certificates therefor at
the office of the Corporation or of any transfer agent for the Preferred Stock,
and shall send notice to the Corporation at such office that the holder elects
to convert the same and shall state therein the holder's name or the name or
names of the holder's nominees in which the holder wishes the certificate or
certificates for shares of Common Stock to be issued. On the date of conversion,
all rights with respect to the Preferred Stock so converted shall terminate,
except any of the rights of the holder thereof, upon surrender of the holder's
certificate or certificates therefor, to receive certificates for the number of
shares of Common Stock into which such Preferred Stock has been converted and
cash in an amount equal to all dividends declared but unpaid thereon and any and
all other amounts owing with respect thereto at such time. If so required by the
Corporation, certificates surrendered for conversion shall be endorsed or
accompanied by written instrument or instruments of transfer, in form
satisfactory to the Corporation, duly executed by the registered holder or by
the holder's attorney duly authorized in writing. No fractional share of Common
Stock shall be issued upon the optional conversion of Preferred Stock. In lieu
of any fractional share to which the holder would otherwise be entitled, the
Corporation shall pay cash equal to such fraction multiplied by the applicable
Conversion Price then in effect. The Corporation shall, as soon as practicable
after

                                      -5-
<PAGE>

surrender of the certificate or certificates for conversion, issue and deliver
at such office to such holder of Preferred Stock, or to the holder's nominee or
nominees, a certificate or certificates for the number of shares of Common Stock
to which the holder shall be entitled as aforesaid, together with cash in lieu
of any fraction of a share and cash in an amount equal to all dividends declared
but unpaid thereon and any and all other amounts owing with respect thereto at
such time. Such conversion shall be deemed to have been made immediately prior
to the close of business on the date of such surrender of the shares of
Preferred Stock to be converted, and the person or persons entitled to receive
the shares of Common Stock issuable upon conversion shall be treated for all
purposes as the record holder or holders of such shares of Common Stock on such
date.

          (d)  Mechanics of Automatic Conversions.  Upon the occurrence of an
               ----------------------------------
event specified in Subsection 2(b), the affected Series of Preferred Stock shall
be converted automatically without any further action by the holders of shares
thereof and whether or not the certificates representing such shares are
surrendered to the Corporation or its transfer agent; provided, however, that
all holders of shares of Preferred Stock being converted shall be sent notice of
the occurrence of an event specified in Subsection 2(b) including the date such
event occurred (the "Automatic Conversion Date"), and the Corporation shall not
be obligated to issue certificates evidencing the shares of Common Stock
issuable upon such conversion unless certificates evidencing such shares of the
Preferred Stock being converted are either delivered to the Corporation or its
transfer agent, or the holder notifies the Corporation or any transfer agent
that such certificates have been lost, stolen, or destroyed and executes an
agreement satisfactory to the Corporation to indemnify the Corporation from any
loss incurred by it in connection therewith and, if the Corporation so elects,
provides an appropriate indemnity bond.  On the Automatic Conversion Date, all
rights with respect to the Preferred Stock so converted shall terminate, except
any of the rights of the holder thereof, upon surrender of the holder's
certificate or certificates therefor, to receive certificates for the number of
share of Common Stock into which such Preferred Stock has been converted,
together with cash in an amount equal to all dividends declared but unpaid on,
and any and all other amounts owing with respect to, the shares of Preferred
Stock converted to and including the time of conversion.  Upon the automatic
conversion of the Preferred Stock, the holders of such Preferred Stock shall
surrender the certificates representing such shares at the office of the
Corporation or of its transfer agent.  If so required by the Corporation,
certificates surrendered for conversion shall be endorsed or accompanied by
written instrument or instruments of transfer, in form satisfactory to the
Corporation, duly executed by the registered holder or by the holder's attorney
duly authorized in writing.  Upon surrender of such certificates there shall be
issued and delivered to such holder, promptly at such office and in the holder's
name as shown on such surrendered certificate or certificates, a certificate or
certificates for the number of shares of Common Stock into which the shares of
the Preferred Stock surrendered were convertible on the date on which such
automatic conversion occurred; together with cash in an amount equal to all
dividends declared but unpaid on, and any and all other amounts owing with
respect to, the shares of Preferred Stock converted to and including the time of
conversion.  No fractional share of Common Stock shall be issued upon the
automatic conversion of the Preferred Stock.  In lieu of any fractional share to
which the holder would otherwise be entitled, the Corporation shall pay cash
equal to such fraction multiplied by the applicable Conversion Price then in
effect.

                                      -6-
<PAGE>

          (e)  Adjustments to Conversion Price for Diluting Issues.
               ---------------------------------------------------

               (i)  Special Definitions.  For purposes of this Subsection 2(e),
                    -------------------
the following definitions shall apply:

                    (1)  "Option" shall mean rights, options or warrants to
                          ------
subscribe for, purchase or otherWise acquire either Common Stock or Convertible
Securities.

                    (2)  "Original Issue Date" shall mean, with respect to each
                          -------------------
series of Preferred Stock, the first date on which a share of such series of
Preferred Stock was issued.

                    (3)  "Convertible Securities" shall mean any evidences of
                          ----------------------
indebtedness, shares of capital stock (other than Common Stock) or other
securities directly or indirectly convertible into or exchangeable for Common
Stock.

                    (4)  "Additional Shares of Common Stock" shall mean all
                          ---------------------------------
shares of Common Stock issued (or, pursuant to Subsection 2(e)(iii), deemed to
be issued) by the Corporation after the Original Issue Date, other than:

                         (A)  shares of Common Stock or Convertible Securities
issued or issuable upon exercise of Options outstanding on the Original Issue
Date;

                         (B)  up to 1,200,000 shares of Common Stock issued or
issuable to officers or employees or directors of, or consultants to, the
Corporation pursuant to a stock purchase or option plan or other employee stock
bonus arrangement (collectively, the "Plans") approved by the Board of
Directors; and

                         (C)  shares of Common Stock issued or issuable upon
conversion of shares of Preferred Stock.

          (ii)  No Adjustment of Conversion Price.  Except as set forth in
                ---------------------------------
Subsection 2(e)(vi), no adjustment in the number of shares of Common Stock into
which a series of Preferred Stock is convertible shall be made, by adjustment in
the Conversion Price for such series of Preferred Stock in respect of the
issuance of Additional Shares of Common Stock, unless the consideration per
share for an Additional Share of Common Stock (determined pursuant to Subsection
2(e)(v)) issued or deemed to be issued by the Corporation is less than the
Conversion Price for such series of Preferred Stock in effect on the date of,
and immediately prior to, the issue of such Additional Share.

          (iii)  Issue of Securities Deemed Issue of Additional Shares of
                 --------------------------------------------------------
Common Stock.
- ------------

                 (1)  Options and Convertible Securities.  In the event the
                      ----------------------------------
Corporation at any time or from time to time after the applicable Original Issue
Date shall issue any Options or Convertible Securities or shall fix a record
date for the determination of holders

                                      -7-
<PAGE>

of any class of securities entitled to receive any such Options or Convertible
Securities, then the maximum number of shares (as set forth in the instrument
relating thereto without regard to any provisions contained therein for a
subsequent adjustment of such number) of Common Stock issuable upon the exercise
of such Options or, in the case of Convertible Securities and Options therefor,
the conversion or exchange of such Convertible Securities, shall be deemed to be
Additional Shares of Common Stock issued as of the time of such issue or, in
case such a record date shall have been fixed, as of the close of business on
such record date, provided that in any such case in which Additional Shares of
Common Stock are deemed to be issued:

                         (A)  no further adjustment in the Conversion Price of
any series of Preferred Stock adjusted as a result of such deemed issuance shall
be made upon the subsequent issue of Convertible Securities or shares of Common
Stock upon the exercise of such Options or conversion or exchange of such
Convertible Securities;

                         (B)  if such Options or Convertible Securities by their
terms provide, with the passage of time or otherwise, for any increase in the
consideration payable to the Corporation, or decrease in the number of shares of
Common Stock issuable, upon the exercise, conversion or exchange thereof, the
Conversion Price of any series of Preferred Stock adjusted upon the original
issue thereof (or upon the occurrence of a record date with respect thereto),
and any subsequent adjustments based thereon, shall, upon any such increase or
decrease becoming effective, be readjusted to reflect such increase or decrease
insofar as it affects such Options or the rights of conversion or exchange under
such Convertible Securities;

                         (C)  upon the expiration of any such Options or any
rights of conversion or exchange under such Convertible Securities which shall
not have been exercised, the Conversion Price of any series of Preferred Stock
adjusted upon the original issue thereof (or upon the occurrence of a record
date with respect thereto), and any subsequent adjustments based thereon, shall,
upon such expiration, be readjusted as if:

                              (I)  In the case of Convertible Securities or
Options for Common Stock the only Additional Shares of Common Stock issued were
the shares of Common Stock, if any, actually issued upon the exercise of such
Options or the conversion or exchange of such Convertible Securities and the
consideration received therefor was the consideration actually received by the
Corporation for the issue of all such Options, whether or not exercised, plus
the consideration actually received by the Corporation upon such exercise, or
for the issue of all such Convertible Securities which were actually converted
or exchanged, plus the additional consideration, if any, actually received by
the Corporation upon such conversion or exchange; and

                              (II)  in the case of Options for Convertible
Securities only the Convertible Securities, if any, actually issued upon the
exercise thereof were issued at the time of issue of such Options, and the
consideration received by the Corporation for the Additional Shares of Common
Stock deemed to have been then issued was the consideration actually received by
the Corporation for the issue of all such Options, whether or not exercised,
plus the consideration deemed to have been received by the Corporation
(determined pursuant to

                                      -8-
<PAGE>

Subsection 2(e)(v)) upon the issue of the Convertible Securities with respect to
which such Options were actually exercised;

                         (D)  no readjustment pursuant to clause (B) or (C)
above shall have the effect of increasing the Conversion Price of any series of
Preferred Stock to an amount which exceeds the lower of (i) the Conversion Price
of such series of Preferred Stock immediately prior to the original adjustment
for such deemed issuance, or (ii) the Conversion Price of such series of
Preferred Stock that would have resulted from any issuance of Additional Shares
of Common Stock between the original adjustment for such deemed issuance and
such readjustment date;

                         (E)  in the case of any Options which expire by their
terms not more than 30 days after the date of issue thereof, no adjustment of
the Conversion Price of any series of Preferred Stock shall be made until the
expiration or exercise of all such Options, whereupon such adjustment shall be
made in the same manner provided in clause (C) above; and

                         (F)  if such record date shall have been fixed and such
Options or Convertible Securities are not issued on the date fixed therefor, the
adjustment previously made in the Conversion Price of any series of Preferred
Stock which became effective on such record date shall be cancelled as of the
close of business on such record date, and thereafter the Conversion Price of
such series of Preferred Stock shall be adjusted pursuant to this Subsection
2(e)(iii) as of the actual date of their issuance.

                    (2)  Stock Dividends, Stock Distributions and Subdivisions.
                         -----------------------------------------------------
In the event the Corporation at any time or from time to time after the
applicable Original Issue Date shall declare or pay any dividend or make any
other distribution on the Common Stock payable in Common Stock or effect a
subdivision of the outstanding shares of Common Stock (by reclassification or
otherwise than by payment of a dividend in Common Stock), then and in any such
event, Additional Shares of Common Stock shall be deemed to have been issued:

                         (A)  in the case of any such dividend or distribution,
immediately after the close of business on the record date for the determination
of holders of any class of securities entitled to receive such dividend or
distribution, or

                         (B)  in the case of any such subdivision, at the close
of business on the date immediately prior to the date upon which such corporate
action becomes effective.

If such record date she have been fixed and no part of such dividend shall been
paid on the date fixed therefor, the adjustment previously made in the
Conversion Price of any series of Preferred Stock which became effective on such
record date shall be cancelled as of the close of business; on such record date,
and thereafter the Conversion Price of such series of Preferred Stock shall be
adjusted pursuant to this Section 2(e)(iii) as of the time of actual payment of
such dividend.

                                      -9-
<PAGE>

          (iv) Adjustment of Conversion Price Upon Issuance of Additional Shares
               -----------------------------------------------------------------
of Common Stock.  In the event that at any time or from time to time after the
- ---------------
applicable Original Issue Date, the Corporation shall issue Additional Shares of
Common Stock (including, without limitation, Additional Shares of Common Stock
deemed to be issued pursuant to Subsection 2(e)(iii)(1) but excluding Additional
Shares of Common Stock deemed to be issued pursuant to Subsection 2(e)(iii)(2),
which event is dealt with in Subsection 2(e)(vi)(1)), without consideration or
for a consideration per share less than the Conversion Price of any series of
Preferred Stock in effect on the date of and immediately prior to such issue,
then and in such event, the Conversion Price of such series of Preferred Stock
shall be reduced, concurrently with such issue, to a price (calculated to the
nearest cent) determined in accordance with the following formula:


                             (P1) (Q1) + (P2) (Q2)
                    NCP =
                             _____________________
                                  Q1   +   Q2

     where:

          NCP       =         New Conversion Price of the affected series of
                              Preferred Stock.

          P(1)      =         Conversion Price for such series of Preferred
                              Stock in effect immediately prior to new issue.

          Q1        =         Number of shares of Common Stock outstanding, or
                              deemed to be outstanding as set forth below,
                              immediately prior to such issue.

          P2        =         Weighted average price per share received by the
                              Corporation upon such issue.

          Q2        =         Number of shares of Common Stock issued, or deemed
                              to have been issued, in the subject transaction.

provided that for the purpose of this Subsection 2(e)(iv), all shares of Common
- --------
Stock issuable upon exercise or conversion of any Options or Convertible
Securities outstanding immediately prior to such issue shall be deemed to be
outstanding, and immediately after any Additional Shares of Common Stock are
deemed issued pursuant to Subsection 2(e)(iii), such Additional Shares of Common
Stock shall be deemed to be outstanding; and provided further, that the
                                             -------- --------
applicable Conversion Price shall not be so reduced at any time if the amount of
such reduction would be an amount less than $.01, but any such amount shall be
carried forward and reduction with respect thereto made at the time of and
together with any subsequent reduction which, together with such amount and any
other amount or amounts so carried forward, shall aggregate $.0l or more.

          (v)  Determination of Consideration.  For purposes of this Subsection
               ------------------------------
2(e), the consideration received by the Corporation for the issue of any
Additional Shares of Common Stock shall be computed as follows:

                                      -10-
<PAGE>

               (1)  Cash and Property:  Such consideration shall:
                    -----------------

                    (A)  insofar as it consists of cash, be computed at the
aggregate amounts of cash received by the Corporation excluding amounts paid or
payable for accrued interest or accrued dividends;

                    (B)  insofar as it consists of property other than cash, be
computed at the fair value thereof at the time of such issue, as determined in
good faith by the Board of Directors; and

                    (C)  in the event Additional Shares of Common Stock are
issued together with other shares or securities or other assets of the
Corporation for consideration which covers both, be the proportion of such
consideration so received, computed as provided in clauses (A) and (B) above, as
determined in good faith by the Board of Directors.

               (2)  Options and Convertible Securities.  The consideration per
                    ----------------------------------
share received by the Corporation for Additional Shares of Common Stock deemed
to have been issued pursuant to Subsection 2(e)(iii)(1), relating to Options and
Convertible Securities, shall be determined by dividing (x) the total amount, if
any, received or receivable by the Corporation as consideration for the issue of
such Options or Convertible Securities, plus the minimum aggregate amount of
additional consideration (as set forth in the instruments relating thereto,
without regard to any provision contained therein for a subsequent adjustment of
such consideration) payable to the Corporation upon the exercise of such Options
or the conversion or exchange of such Convertible Securities, or in the case of
Options for Convertible Securities, the exercise of such Options for Convertible
Securities and the conversion or exchange of such Convertible Securities, by (y)
the maximum number of shares of Common Stock (as set forth in the instruments
relating thereto, without regard to any provision contained therein for a
subsequent adjustment of such number) issuable upon the exercise of such Options
or the conversion or exchange of such Convertible Securities.

         (vi)  Adjustment for Dividends, Distributions, Subdivisions,
               ------------------------------------------------------
Combinations or Consolidations of Common Stock.
- ----------------------------------------------

               (1)  Stock Dividends, Distributions or Subdivisions. In the event
                    ----------------------------------------------
the Corporation shall be deemed to issue Additional Shares of Common Stock
pursuant to Subsection 2(e)(iii)(2) in a stock dividend, stock distribution or
subdivision, the Conversion Price of each series of Preferred Stock in effect
immediately before such deemed issuance shall, concurrently with the
effectiveness of such deemed issuance, be proportionately decreased.

               (2)  Combinations or Consolidations.  In the event the
                    ------------------------------
outstanding shares of Common Stock shall be combined or consolidated, by
reclassification or otherwise, into a lesser number of shares of Common Stock,
the Conversion Price of each series of Preferred Stock in effect immediately
prior to such combination or consolidation shall,

                                     -11-
<PAGE>

concurrently with the effectiveness of such combination or consolidation, be
proportionately increased.

          (f)  Adjustments for Certain Dividends and Distributions.  In the
               ---------------------------------------------------
event that at any time or from time to time after the applicable Original Issue
Date the Corporation shall make or issue, or fix a record date for the
determination of holders of Common Stock entitled to receive, a dividend or
other distribution payable in securities of the Corporation other than shares of
Common Stock, then and in each such event provision shall be made so that the
holders of Preferred Stock shall receive upon conversion thereof in addition to
the number of shares of Common Stock receivable thereupon, the amount of
securities of the Corporation that they would have received had their Preferred
Stock been converted into Common Stock on the date of such event and had they
thereafter, during the period from the date of such event to and including the
conversion date, retained such securities receivable by them as aforesaid during
such period, giving application during such period to all adjustments called for
herein.

          (g)  Adjustment for Reclassification, Exchange, or Substitution.  In
               ----------------------------------------------------------
the event that at any time or from time to time after the applicable Original
Issue Date, the Common Stock issuable upon the conversion of Preferred Stock
shall be changed into the same or a different number of shares of any class or
classes of stock, whether by capital reorganization, reclassification, or
otherwise (other than a subdivision or combination of shares or stock dividend
provided for above, or a merger, consolidation, or sale of assets provided for
below), then and in each such event the holder of any share or shares of
Preferred Stock shall have the right thereafter to convert such shares into the
kind and amount of shares of stock and other securities and property receivable
upon such reorganization, reclassification, or other change, by the holder of a
number of shares of Common Stock equal to the number of shares of Common Stock
into which such shares of Preferred Stock might have been converted immediately
prior to such reorganization, reclassification, or change, all subject to
further adjustment as provided herein.

          (h)  Adjustment for Merger, Consolidation or Sale of Assets.  In the
               ------------------------------------------------------
event that at any time or from time to time after the applicable Original Issue
Date, the Corporation shall merge or consolidate with or into another entity or
sell all or substantially all of its assets, each share of Preferred Stock as to
which such consolidation, merger or sale is not treated as a liquidation under
Subsection l(c) shall thereafter be convertible into the kind and amount of
shares of stock or other securities or property to which a holder of the number
of shares of Common Stock of the Corporation deliverable upon conversion of such
Preferred Stock would have been entitled to receive upon such consolidation,
merger or sale; and, in such case, appropriate adjustment (as determined in good
faith by the Board of Directors) shall be made in the application of the
provisions set forth in this Section 2 with respect to the rights and interest
thereafter of the holders of Preferred Stock, to the end that the provisions set
forth in this Section 2 (including provisions with respect to changes in and
other adjustments of the Conversion Price) shall thereafter be applicable, as
nearly as reasonably may be, in relation to any shares of stock or other
property thereafter deliverable upon the conversion of Preferred Stock.

          (i)  No Impairment.  The Corporation shall not, by amendment of its
               -------------
Certificate of Incorporation or through any reorganization, transfer of assets,
consolidation,

                                     -12-
<PAGE>

merger, dissolution, issue or sale of securities or any other voluntary action,
avoid or seek to avoid the observance or performance of any of the term to be
observed or performed hereunder by the Corporation but shall at all times in
good faith assist in the carrying out of all the provisions of this Section 2
and in the taking of all such action as may be necessary or appropriate in order
to protect the Conversion Rights of the holders of Preferred Stock against
impairment.

          (j)  Certificate as to Adjustments.  Upon the occurrence of each
               -----------------------------
adjustment or readjustment of the Conversion Price of any series of Preferred
Stock pursuant to this Section 2, the Corporation at its expense shall promptly
compute such adjustment or readjustment in accordance with the terms hereof and
furnish to each holder of such series of Preferred Stock a certificate setting
forth such adjustment or readjustment and showing in detail the facts upon which
such adjustment or readjustment is based.  The Corporation shall, upon the
written request at any time of any holder of any such series of Preferred Stock,
furnish or cause to be furnished to such holder a like certificate setting forth
(i) such adjustments and readjustments, (ii) the Conversion Price of such series
of Preferred Stock at the time in effect, and (iii) the number of shares of
Common Stock and the amount, if any, of other property which at the time would
be received upon the conversion of each share of such series of Preferred Stock.

          (k)  Notices of Record Date.  In the event of any taking by the
               ----------------------
Corporation of a record of the holders of any class of securities for the
purpose of determining the holders thereof who are entitled to receive any
dividend (other than a cash dividend which is the same as cash dividends paid in
previous quarters) or other distribution, the Corporation shall send notice to
each holder of Preferred Stock at least ten (10) days prior to such record date
specifying the date on which any such record is to be taken for the purpose of
such dividend or distribution.

          (l)  Common Stock Reserved.  The Corporation shall reserve and keep
               ---------------------
available out of its authorized but unissued Common Stock such number of shares
of Common Stock as shall from time to time be sufficient to effect conversion of
the Preferred Stock.

          (m)  Certain Taxes.  The Corporation shall pay any issue or transfer
               -------------
taxes payable in connection with the conversion of Preferred Stock, provided,
however, that the Corporation shall not be required to pay any tax which may be
payable in respect of any transfer to a name other than that of the holder of
the Preferred Stock.

          (n)  Closing of Books.  The Corporation shall at no time close its
               ----------------
transfer books against the transfer of any Preferred Stock or of any shares of
Common Stock issued or issuable upon the conversion of any shares of Preferred
Stock in any manner which interferes with the timely conversion or transfer of
such Preferred Stock or Common Stock.

     Section 3.  Restrictions.
     ---------   ------------

          (a)  At any time when shares of Preferred Stock are outstanding,
except where the vote of the holders of a greater number of shares of the
Corporation is required by law

                                     -13-
<PAGE>

or by this Certificate of Incorporation, and in addition to any other vote
required by law or this Certificate of Incorporation, without the affirmative
vote of the holders of at least sixty percent (60%) of the then outstanding
shares of Preferred Stock (with calculations based upon the number of shares of
Common Stock into which such shares of Preferred Stock are then convertible),
voting collectively as a single class, the Corporation will not:

               (i)    consent to any liquidation, dissolution or winding up of
the Corporation or merge or consolidate with or into any other entity or
entities;

               (ii)   sell, abandon, transfer, lease or otherwise dispose of all
or any substantially portion of its properties and other assets; or

               (iii)  amend this Certificate of Incorporation or the
Corporation's By-Laws.

          (b)  At any time when shares of Series C Preferred Stock are
outstanding, except where the vote of the holders of a greater number of shares
of the Corporation is required by law or by this Certificate of Incorporation,
and in addition to any other vote required by law or this Certificate of
Incorporation, without the affirmative vote of the holders of at least two-
thirds of the then outstanding shares of the Series C Preferred Stock, the
Corporation will not:

               (i)   amend, alter or change the designation or any preferences,
voting powers, qualifications, or special or relative rights or privileges of
the Series C Preferred Stock in a manner adverse to the interests of the holders
of the Series C Preferred stock in any material respect;

               (ii)  increase the authorized number of shares of Series C
Preferred Stock;

               (iii) create or authorize the creation of any additional class or
series of shares of stock unless such class or series ranks junior to the Series
C Preferred Stock as to both dividends and the distribution of assets on the
liquidation, dissolution, winding up or insolvency of the Corporation, or
increase the authorized amount of any other class or series of shares of stock
unless the same ranks junior to the Series C Preferred Stock as to dividends and
the distribution of assets on the liquidation, dissolution, winding up or
insolvency of the Corporation, or create or authorize any obligation or security
convertible into shares of the Series C Preferred Stock or into shares of any
other class or series of shares of stock unless the same ranks junior to the
Series C Preferred Stock as to dividends and the distribution of assets on the
liquidation, dissolution, winding up or insolvency of the Corporation, Whether
any such creation, authorization or increase shall be by means of amendment to
this Certificate of Incorporation or by merger, consolidation or otherwise.

          (c)  At any time when shares of Series B Preferred Stock are
outstanding, except where the vote of the holders of a greater number of shares
of the Corporation is required by law or by this Certificate of Incorporation,
and in addition to any

                                     -14-
<PAGE>

other vote required by law or this Certificate of Incorporation, without the
affirmative vote of the holders of at least eighty-five percent (85%) of the
then outstanding shares of the Series B Preferred Stock, the Corporation will
not:

               (i)   amend, alter or change the designation or any preferences,
voting powers, qualifications, or special or relative rights or privileges of
the Series B Preferred Stock in a manner adverse to the interests of the holders
of the Series B Preferred Stock in any material respect;

               (ii)  increase the authorized number of shares of the Series
B Preferred Stock;

               (iii) create or authorize the creation of any additional class or
series of shares of stock unless such class or series ranks junior to the Series
B Preferred Stock to both dividends and the distribution of assets on the
liquidation, dissolution, winding up or insolvency of the Corporation, or
increase the authorized amount of any other class or series of shares of stock
unless the same ranks junior to the Series B Preferred Stock as to dividends and
the distribution of assets on the liquidation, dissolution, winding up or
insolvency of the Corporation, or create or authorize any obligation or security
convertible into shares of the Series B Preferred Stock or into shares of any
other class or series of shares of stock unless the same ranks junior to the
Series B Preferred Stock as to dividends and the distribution of assets on the
liquidation, dissolution, winding up or insolvency of the Corporation, whether
any such creation, authorization or increase shall be by means of amendment to
this Certificate of Incorporation or by merger, consolidation or otherwise.

               (d)  At any time when shares of Series A Preferred Stock are
outstanding, except where the vote of the holders of a greater number of shares
of the Corporation is required by law or by this Certificate of Incorporation,
and in addition to any other vote required by law or this Certificate of
Incorporation, without the affirmative vote of the holders of at least eighty
percent (80%) of the then outstanding shares of the Series A Preferred Stock,
the Corporation will not:

                    (i)    amend, alter or change the designation or any
preferences, voting powers, qualifications, or special or relative rights or
privileges of the Series A Preferred stock in a manner adverse to the interests
of the holders of the Series A Preferred Stock in any material respect;

                    (ii)   increase the authorized number of shares of the
Series A Preferred Stock;

                    (iii)  create or authorize the creation of any additional
class or series of shares of stock unless such class or series ranks junior to
the Series A Preferred Stock to both dividends and the distribution of assets on
the liquidation, dissolution, winding up or insolvency of the

                                     -15-
<PAGE>

Corporation, or increase the authorized amount of any other class or series of
shares of stock unless the same ranks junior to the Series A Preferred Stock as
to dividends and the distribution of assets on the liquidation, dissolution,
winding up or insolvency of the Corporation, or create or authorize any
obligation or security convertible into shares of the Series A Preferred Stock
or into shares of any other class or series of shares of stock unless the same
ranks junior to the Series A Preferred Stock as to dividends and the
distribution of assets on the liquidation, dissolution, winding up or insolvency
of the Corporation, whether any such creation, authorization or increase shall
be by means of amendment to this Certificate of Incorporation or by merger,
consolidation or otherwise.

     Section 4.  Voting Rights.  Except as otherwise required by law or
     ---------   -------------
hereinafter set forth, the holders of Preferred Stock shall be entitled to
notice of any meeting of stockholders and shall vote together with the holders
of Common Stock as a single class upon any matter submitted to the stockholders
for a vote, on the following basis:

               (a)  Holders of Common Stock shall have one vote per share; and

               (b)  Holders of Preferred Stock shall have that number of votes
per share as is equal to the number of shares of Common Stock (including
fractions of a share) into which each such share of Preferred Stock held by such
holder could be converted on the date for determination of stockholders entitled
to vote at the meeting or on the date of any written consent.

     With respect to all questions as to which, under law, stockholders are
required to vote by classes or series, each series of Preferred Stock shall vote
separately as a single class and series apart from each other and from the
Common Stock.

     Section 5.  Dividends.
     ---------   ---------

               (a)  Dividends may be declared and paid on the Preferred Stock
and the Common Stock from funds lawfully available therefor as and when
determined by the Board of Directors.

               (b)  If, when and as dividends are declared and paid on shares of
the Series B Preferred Stock, the Corporation shall declare and pay at the same
time to each holder of the Series C Preferred Stock, a dividend at the same
rate, based on the number of shares of Common Stock into which the Series C
Preferred Stock and the Series B Preferred Stock are convertible on the record
date for the determination of holders of the Series B Preferred Stock entitled
to receive such dividend.

               (c)  If, when and as dividends are declared and paid on shares of
the Series A Preferred Stock, the Corporation shall declare and pay at the same
time to each holder of the Series C Preferred Stock and the Series B Preferred
Stock, a dividend at the same rate, based on the number of shares of Common
Stock into which each series of Preferred Stock is convertible on the record
date for the determination of holders of the Series A Preferred Stock entitled
to receive such dividend.

               (d)  If, when and as dividends are declared and paid on shares of
Common Stock, the Corporation shall declare and pay at the same time to each
holder of the

                                     -16-
<PAGE>

Preferred Stock, a dividend equal to the dividend which would have been payable
to such holder if the shares of the Preferred Stock held by such holder had been
converted into Common Stock on the record date for the determination of holders
of Common Stock entitled to receive such dividend.

     Section 6.  Redemption.
     ---------   ----------

               (a)  Series B Preferred Stock.
                    ------------------------

                    (i)  In the event that the Corporation shall exercise its
put option to sell shares of capital stock of Sequenom Instruments GmbH to
Technologie-Beteiligungs-Gesellschaft mbH der Deutschen Ausgleichsbank ("TBG")
pursuant to that certain Kooperationsvertrag between the Corporation and TBG
relating to the investment by the Corporation of DM 3 million in Sequenom
Instruments GmbH, the Corporation shall, within 30 days after receipt of the
proceeds of the sale of such shares to the TBG, send notice of such exercise
(the "Series B Put Exercise Notice") to each holder of record of Series B
Preferred Stock, specifying (A) the amount of proceeds so received from the TBG
net of any expenses incurred in connection therewith (the "Series B Put Net
Proceeds"), (B) the date (the "Series B Redemption Date") on which the
Corporation will redeem shares of Series B Preferred Stock from electing holders
of the Series B Preferred Stock in accordance with this Section 6, which Series
B Redemption Date shall be not less than 45 days nor more than 90 days after the
date of such notice (the "Series B Notice Date") and (C) each such holder's
Series B Pro Rata Redemption Amount (as hereinafter defined).

                    (ii)  Each holder of Series B Preferred Stock may elect to
have the Corporation redeem from it on the Series B Redemption Date, to the
extent the Corporation has funds legally available for such purpose, up to a
number of shares of Series B Preferred Stock equal to such holder's Series B Pro
Rata Redemption Amount (as hereinafter defined) at a redemption price of $1.50
per share. Such election may be made only by delivering to the Corporation
within thirty (30) days after the Series B Notice Date (A) a written election
signed by such holder specifying the number of shares of Series B Preferred
Stock so to be redeemed (which number shall be not more than such holder's
Series B Pro Rate Redemption Amount), and (B) certificates for the shares of
Series B Preferred Stock so to be redeemed, together with stock powers therefor
duly executed by such holder in blank.

                    (iii)  For purposes of this Subsection 6(a), each holder of
Series B Preferred Stock's "Series B Pro Rata Redemption Amount" shall be the
greatest whole number represented by a fraction, the numerator or which is the
product of the number of shares of Series B Preferred Stock held by such holder
times the Series B Put Net Proceeds, and the denominator or which is the product
of the total number of shares of Series B Preferred Stock issued and outstanding
times $1.50.

                    (iv)  On the Series B Redemption Date the Corporation shall
redeem from the electing holders of Series B Preferred Stock the shares of
Series B Preferred Stock as to which election notices have been properly sent,
to the extent the Corporation has funds legally available for such purpose.

                                     -17-
<PAGE>

          (v) If the funds of the Corporation legally available for redemption
of shares of Series B Preferred Stock on the Series B Redemption Date are
insufficient to redeem the total number of shares of Series B Preferred Stock
submitted for redemption, those funds which are legally available will be used
to redeem the maximum possible number of whole shares ratably among the holders
of such shares in accordance with the manner of determining the Series B Pro
Rata Redemption Amount set forth above.  The shares of Series B Preferred Stock
not redeemed shall remain outstanding and entitled to all rights and preferences
provided herein.

               (b)  Series C Preferred Stock.
                    ------------------------

          (i) In the event that (x) the Corporation shall use proceeds from the
financing contemplated by the Series C Convertible Preferred Stock Purchase
Agreement dated on or about May __, 1997 to acquire additional shares of the
capital stock of Sequenom Instruments GmbH and in connection therewith shall
acquire a put option to sell such shares of Sequenom Instruments GmbH to TBG,
and (y) thereafter the Corporation shall exercise such put option, then the
Corporation shall, within 30 days after receipt of the Proceeds of the sale of
such shares to the TBG, send notice of such exercise (the "Series C Put Exercise
Notice") to each holder of record of Series C Preferred Stock, specifying (A)
the amount of proceeds so received from the TBG net of any expenses incurred in
connection therewith (the "Series C Put Net Proceeds"), (B) the date (the
"Series C Redemption Date") on which the Corporation will redeem shares of
Series C Preferred Stock from electing holders of the Series C Preferred Stock
in accordance with this Section 6, which Series C Redemption Date shall be not
less than 45 days nor more than 90 days after the date of such notice (the
"Series C Notice Date") and (C) each such holder's Series C Pro Rata Redemption
Amount (as hereinafter defined).

          (ii) Each holder of Series C Preferred Stock may elect to have the
Corporation redeem from it on the Series C Redemption Date, to the extent the
Corporation has funds legally available for such purpose, up to a number of
shares of Series C Preferred Stock equal to such holder's Series C Pro Rata
Redemption Amount (as hereinafter defined) at a redemption price of $3.15 per
share.  Such election may be made only by delivering to the Corporation within
thirty (30) days after the Series C Notice Date (A) a written election signed by
such holder specifying the number of shares of Series C Preferred Stock so to be
redeemed (which number shall be not more than such holder's Series C Pro Rata
Redemption Amount), and (B) certificates for the shares of Series C Preferred
Stock so to be redeemed, together with stock powers therefor duly executed by
such holder in blank.

          (iii)  For purposes of this Subsection 6(b), each holder of Series C
Preferred Stock's "Series C Pro Rata Redemption Amount" shall be the greatest
whole number represented by a fraction, the numerator or which is the product of
the number of shares of Series C Preferred Stock held by such holder times the
Series C Put Net Proceeds, and the denominator or which is the product of the
total number of shares of Series C Preferred Stock issued and outstanding times
$1.50.

                                     -18-
<PAGE>

          (iv) On the Series C Redemption Date the Corporation shall redeem from
the electing holders of Series C Preferred Stock the shares of Series C
Preferred Stock as to which election notices have been properly sent, to the
extent the Corporation has funds legally available for such purpose.

          (v) If the funds of the Corporation legally available for redemption
of shares of Series C Preferred Stock on the Series C Redemption Date are
insufficient to redeem the total number of shares of Series C Preferred Stock
submitted for redemption, those funds which are legally available will be used
to redeem the maximum possible number of whole shares ratably among the holders
of such shares in accordance with the manner of determining the Series C Pro
Rata Redemption Amount set forth above.  The shares of Series C Preferred Stock
not redeemed shall remain outstanding and entitled to all rights and preferences
provided herein.

          (c) Concurrent Redemption of Series B Preferred Stock and Series C
              --------------------------------------------------------------
Preferred Stock.  If the Corporation shall become obligated under this Section 6
- ---------------
to redeem shares of both Series B Preferred Stock and Series C Preferred Stock
at a time when the funds of the Corporation legally available for redemption of
such shares on the Series B Redemption Date and the Series C Redemption Date
would be insufficient to redeem the total number of shares of Series B Preferred
Stock and Series C Preferred Stock submitted for redemption, those funds which
are legally available will be used to redeem the maximum possible number of
whole shares of Series B Preferred Stock and Series C Preferred Stock ratably
among the holders of such shares in accordance with the manner of determining
their respective Series B Pro Rata Redemption Amount and Series C Pro Rata
Redemption Amount set forth above.  The shares of Series B Preferred Stock and
Series C Preferred Stock not redeemed shall remain outstanding and entitled to
all rights and preferences provided herein.

     Section 7.  Residual Rights.  All rights accruing to the outstanding shares
     ---------   ---------------
of the Corporation not expressly provided for to the contrary herein shall be
vested in the Common Stock.

          Section 8.  Notices.  All notices required or permitted to be sent
          ---------   -------
pursuant to this Article Fourth shall be deemed sufficient if contained in a
written instrument and delivered in person or duly sent by first-class mail
postage prepaid (other than in the case of notices to non-U.S. residents) or by
fax or DHL, Federal Express or other recognized express international courier
service, addressed to the intended recipient at the recipient's address as it
appears on the books of the Corporation.

                                     -19-
<PAGE>

                                  EXHIBIT 2.1
                                  -----------

                                Form of Warrant
                                ---------------
<PAGE>

NEITHER THIS WARRANT NOR THE SHARES OF CAPITAL STOCK PURCHASABLE HEREUNDER HAVE
BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY STATE
SECURITIES LAW AND, ACCORDINGLY, NEITHER THIS WARRANT NOR SUCH SHARES MAY BE
OFFERED FOR SALE, SOLD, PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED UNLESS
THE REGISTRATION PROVISIONS OF SUCH ACT AND ALL APPLICABLE STATE SECURITIES LAWS
HAVE BEEN COMPLIED WITH OR UNLESS THE CORPORATION HAS RECEIVED AN OPINION OF
COUNSEL ACCEPTABLE TO IT THAT SUCH REGISTRATION IS NOT REQUIRED.

THE SHARES OF CAPITAL STOCK PURCHASABLE HEREUNDER ARE SUBJECT TO THE TERMS AND
PROVISIONS OF A VOTING AGREEMENT AMONG THE CORPORATION AND CERTAIN STOCKHOLDERS
OF THE CORPORATION.  THE CORPORATION SHALL FURNISH A COPY OF SUCH VOTING
AGREEMENT TO ANY REGISTERED HOLDER OF THIS WARRANT OR SUCH SHARES OF CAPITAL
STOCK UPON WRITTEN REQUEST AND WITHOUT CHARGE.


                                 SEQUENOM, INC.

                             STOCK PURCHASE WARRANT

                      Warrant to Purchase _____ Shares of
                      Series C Convertible Preferred Stock

                           Issued to ________________

                             Void after May __, 2004


     Sequenom, Inc., a Delaware corporation (the "Corporation"), hereby
covenants and agrees with ____________ as follows:

1.  The Warrant.
    -----------

     1.01  For value received and subject to the terms and conditions
hereinafter set forth, the registered holder of this Warrant (the
"Warrantholder") is entitled upon its surrender, with the subscription form
annexed hereto duly executed, at the office of the Corporation at 11555 Sorrento
Valley Road, Suite C, San Diego, California 92121, or at such other office as
the Corporation shall notify the Warrantholder in writing, to purchase from the
Corporation __________ fully paid and non-assessable shares of the Series C
Convertible Preferred Stock, par value $.001 per share ("Series C Preferred
Stock"), of the Corporation for $3.15 per share (the "Exercise Price"), subject
to adjustment as set forth in Sections 2 and 4 hereof.  This Warrant may be
exercised in full or in part from time to time.  As promptly as practicable
after surrender of this Warrant and receipt of payment of the Exercise Price,
the Corporation shall issue and deliver to the Warrantholder a certificate or
certificates for shares of Series C Preferred
<PAGE>

Stock, in certificates of such denominations and in such name as the
Warrantholder may specify, together with any other stock, securities or property
that such holder may be entitled to receive pursuant hereto. This Warrant shall
expire at the close of business on May 8, 2004, and shall be void thereafter.
Upon and after the Automatic Conversion Effective Time (as defined in Section
4), the right to purchase Series C Preferred Stock granted herein shall
terminate, and this Warrant shall represent the right to purchase shares of the
Common Stock, par value $.001 per share, of the Corporation ("Common Stock") as
provided in Section 4 hereof. The shares of Series C Preferred Stock, Common
Stock or securities or other property purchasable upon exercise of this Warrant
are sometimes referred to hereinafter as "Warrant Shares".

     1.02  Prior to the Automatic Conversion Effective Time (as defined in
Section 4), the Corporation shall at all times have authorized and reserved for
purposes of issue upon exercise of the rights evidenced hereby, a sufficient
number of shares of its Series C Preferred Stock to provide for the exercise of
such rights, and shall at all times have authorized and reserved a sufficient
number of shares of its Common Stock for purposes of issue upon conversion of
such shares of Series C Preferred Stock under the terms of the Charter (as
defined in Subsection 2.05). From and after the Automatic Conversion Effective
Time, the Corporation shall at all times have authorized and reserved for
purposes of issue upon exercise of the rights evidenced hereby, a sufficient
number of shares of its Common Stock to provide for the exercise of such rights.
Upon surrender for exercise, this Warrant shall be cancelled and shall not be
reissued; provided, however, that upon the partial exercise hereof a substitute
Warrant of like tenor and date to the original Warrant representing the rights
to subscribe for and purchase any such unexercised portion hereof shall be
issued.

     1.03  This Warrant may be subdivided into one or more stock purchase
warrants entitling the Warrantholder to purchase Warrant Shares in multiples of
one or more whole shares, upon surrender of the Warrant by the Warrantholder for
such purpose at the office of the Corporation.

     1.04  The Corporation shall maintain at its office (or at such other office
or agency of the Corporation as it may from time to time designate in writing to
the Warrantholder), a register containing the names and address of the holder of
this Warrant.  The registered holder of this Warrant shall be the person in
whose name this Warrant is originally issued and registered, unless a subsequent
holder shall have presented to the Corporation the Warrant, duly assigned to
him, for inspection, and a written notice of his acquisition of the Warrant and
designating in writing the address of such holder, in which case such subsequent
holder of the Warrant shall become a subsequent registered holder, and a
Warrantholder as defined herein.  Any Warrantholder may change his address as
shown on such register by written notice to the Corporation requesting such
change.  Any written notice required or permitted to be given to any
Warrantholder shall be delivered in person or duly sent by first class mail
postage prepaid (other than to non-U.S. parties) or fax or DHL, Federal Express
or other internationally recognized express courier service, to such
Warrantholder at his address as shown on such register.

     1.05  If any shares of Common Stock issuable hereunder upon and after the
Corporation's initial public offering of Common Stock require listing on any
domestic securities exchange, before such shares may be issued upon exercise of
this Warrant, the Corporation shall,

                                      -2-
<PAGE>

at its expense and as expeditiously as possible, use its best efforts to cause
such shares to be duly approved for listing on such domestic securities
exchange.

2.  Adjustment Rights.
    -----------------

     The Exercise Price and the number of Warrant Shares purchasable hereunder
are subject to adjustment, as follows:

     2.01  If the Corporation shall effect a subdivision or combination or
consolidation of shares (whether by way of stock split, reverse stock split or
otherwise) or other capital reorganization or reclassification of any class or
series of the capital stock of the Corporation for which this Warrant is then
exercisable, or the payment of a stock dividend or other distribution of stock
with respect to any such class or series of capital stock, then the number of
Warrant Shares purchasable hereunder and the Exercise Price shall be
appropriately adjusted in such a manner as to entitle the Warrantholder to
receive upon exercise of this Warrant, for the same aggregate consideration, the
same total number, type, class and series of securities and other property as
such Warrantholder would have received as a result of the event requiring the
adjustment had such Warrantholder exercised this Warrant in full immediately
prior to such event.

     2.02  If there shall occur any consolidation or merger of the Corporation
or sale of all or substantially all of the Corporation's assets, then as a
condition of such consolidation, merger or sale, lawful and adequate provision
shall be made whereby the Warrantholder shall thereafter have the right to
purchase and receive upon the basis and upon the terms and conditions herein
specified and in lieu of the Warrant Shares immediately theretofore purchasable
and receivable upon exercise of this Warrant, such securities and other property
as such Warrantholder would have received as a result of the event requiring the
adjustment had such Warrantholder exercised this Warrant in full immediately
prior to such event, and in any such case appropriate provision shall be made
with respect to the rights and interests of the Warrantholder to the end that
the provisions hereof shall thereafter be applicable, as nearly as may be, in
relation to the securities and other property thereafter deliverable upon the
exercise hereof.

     2.03  Upon the occurrence of any event specified in Subsection 2.01 or
Subsection 2.02, then, and in each such case, the Corporation shall give written
notice thereof to the Warrantholder in accordance with Subsection 1.04, which
notice shall state the adjustment in the Warrant Shares and the Exercise Price
resulting from such event, and shall set forth in reasonable detail the method
of calculation and the facts upon which such calculation is based.

     2.04  In case at any time: (1) the Corporation shall pay any dividend or
make any distribution (other than regular cash dividends from earnings or earned
surplus paid at an established rate) to the holders of its Series C Preferred
Stock or Common Stock or offer to all holders of its Series C Preferred Stock or
Common Stock the right to subscribe for the purchase of any shares of capital
stock or securities convertible into or exercisable for such shares of capital
stock; (2) there shall be any capital reorganization or reclassification of the
capital stock of the Corporation, or consolidation or merger of the Corporation,
or sale of all or substantially all of its assets; or (3) there shall be a
voluntary or involuntary dissolution, liquidation or

                                      -3-
<PAGE>

winding-up of the Corporation; then, in any one or more of such cases, the
Corporation shall give written notice thereof to the Warrantholder in accordance
with Subsection 1.04, which notice shall state the date on which (a) the books
of the Corporation shall close or a record date shall be fixed for determining
the stockholders entitled to such dividend, distribution or subscription rights,
or (b) such reorganization, reclassification, consolidation, merger, sale,
dissolution, liquidation or winding-up shall take place, as the case may be.
Such notice shall also provide reasonable details of the proposed transaction
and specify the date as of which the record holders of Series C Preferred Stock
or Common Stock shall participate in such dividend, distribution or subscription
rights, or shall be entitled to exchange their Series C Preferred Stock or
Common Stock for securities or other property deliverable upon such
reorganization, reclassification, consolidation, merger, sale, dissolution,
liquidation or winding-up, as the case may be. Such written notice shall be
given at least fifteen (15) days prior to the action in question and not less
than fifteen (15) days prior to the record date or the date on which the
Corporation's transfer books are closed in respect thereto.

     2.05  Antidilution rights applicable to the Series C Preferred Stock
purchasable hereunder are set forth in the Corporation's Certificate of
Incorporation, as amended through the date hereof, a true and complete copy of
which has been furnished to Warrantholder (the "Charter").  The Corporation
shall promptly provide the Warrantholder with any restatement, amendment,
modification or waiver of the Charter and with any Certificate of Adjustment
sent to the holders of Series C Preferred Stock in accordance with the Charter
relating to any adjustment or readjustment of the Conversion Price of the Series
C Preferred Stock.

3.  Payment of Exercise Price.  The Exercise Price may be paid at the
    -------------------------
Warrantholder's election either (i) by cash, certified or official bank check,
or wire transfer of funds to an account designated by the Corporation, or (ii)
by surrender of Warrants ("Net Issuance") as determined below.  If the
Warrantholder elects the Net Issuance method, the Corporation shall issue Series
C Preferred Stock or Common Stock as follows:

     (A) Prior to the Automatic Conversion Effective Time (as defined in Section
4), the Corporation shall issue Series C Preferred Stock in accordance with the
following formula:

<TABLE>
<S>              <C>     <C>

                 X   =   (Y)(A-B)/A

     Where:      X   =   the number of shares of Series C Preferred Stock to be issued to the Warrantholder

                 Y   =   the number of shares of Series C Preferred Stock requested to be exercised under this Warrant

                 A   =   the current fair market value of one (1) share of Series C Preferred Stock

                 B   =   the Exercise Price
</TABLE>

                                      -4-
<PAGE>

     As used herein, the current fair market value of a share of Series C
Preferred Stock shall mean the price per share which the Corporation could
obtain from a willing buyer for shares of Series C Preferred Stock, as
determined in good faith by the Corporation's Board of Directors, unless the
Corporation shall become subject to a merger, acquisition or other consolidation
pursuant to which the holders of Series C Preferred Stock receive securities
and/or other property in exchange for their Series C Preferred Stock, in which
case the fair market value of Series C Preferred Stock shall be deemed to be the
value of the securities and other property received by the holders of the
Corporation's Series C Preferred Stock per share of Series C Preferred Stock
pursuant to such merger, acquisition or other consolidation.

     (B) Upon and after the Automatic Conversion Effective Time, the Corporation
shall issue Common Stock in accordance with the following formula:

<TABLE>
<S>              <C>     <C>
                 X   =   (Y)(A-B)/A

     Where:      X   =   the number of shares of Common Stock to be issued to the Warrantholder

                 Y   =   the number of shares of Common Stock requested to be exercised under this Warrant

                 A   =   the fair market value of one (1) share of Common Stock

                 B   =   the Exercise Price
</TABLE>

     As issued herein, current fair market value of Common Stock shall mean with
respect to each share of Common Stock:

          (i) if the exercise is in connection with the Corporation's initial
     public offering of Common Stock, and if the Corporation's Registration
     Statement relating to such public offering has been declared effective by
     the SEC, then the initial "Price to Public" specified in the final
     prospectus with respect to the offering;

          (ii) if this Warrant is exercised after, and not in connection with,
     the Corporation's initial public offering of Common Stock and

               (a) if the Common Stock is traded on a national securities
          exchange or quoted on the Nasdaq Stock Market, the fair market value
          shall be deemed to be the average of the closing prices over a twenty-
          one (21) day period ending three days before the day the current fair
          market value of the Common Stock is being determined; or

               (b) if the Common Stock is not listed on a national securities
          exchange or quoted on the Nasdaq Stock Market but is actively traded
          over-the-counter, the fair market value shall be deemed to be the
          average of the closing bid and asked prices reported by the National
          Quotation Bureau (or similar system) over the

                                      -5-
<PAGE>

          twenty-one (21) day period ending three days before the day the
          current fair market value of the Common Stock is being determined;

          (iii)  if at any time the Common Stock is not listed on any national
     securities exchange or quoted on the Nasdaq Stock Market or actively traded
     or in the over-the-counter market, the current fair market value of Common
     Stock shall be the price per share which the Corporation could obtain from
     a willing buyer (not a current employee or director) for shares of Common
     Stock sold by the Corporation, from authorized but unissued shares, as
     determined in good faith by its Board of Directors, unless the Corporation
     shall become subject to a merger, acquisition or other consolidation
     pursuant to which the holders of Common Stock receive securities and/or
     other property in exchange for their Common Stock, in which case the fair
     market value of Common Stock shall be deemed to be the value of the
     securities and other property received by the holders of the Corporation's
     Common Stock per share of Common Stock pursuant to such merger, acquisition
     or other consolidation.

     Upon partial exercise of this Warrant, the Corporation shall promptly issue
an amended Warrant representing the remaining number of shares purchasable
hereunder.  All other terms and conditions of such amended Warrant shall be
identical to those contained herein, including, but not limited to the Effective
Date hereof.

4.   Automatic Conversion of Series C Preferred Stock.  If at any time the
     ------------------------------------------------
issued and outstanding shares of the Corporation's Series C Preferred Stock
shall be automatically converted into shares of Common Stock under the terms of
the Charter, then upon and after the effective time of such automatic conversion
of the Series C Preferred Stock (the "Automatic Conversion Effective Time"), the
right to purchase Series C Preferred Stock granted herein shall terminate, and
this Warrant shall represent the right to purchase a number of shares of Common
Stock calculated as follows:

<TABLE>
<S>              <C>     <C>
                 X   =   (Y)(Z)

     where:      X   =   the number of shares of Common Stock purchasable under this Warrant upon and after such
                         Automatic Conversion Effective Time

                 Y   =   the number of shares of Series C Preferred Stock purchasable under this Warrant
                         immediately prior to such Automatic Conversion Effective Time

                 Z   =   the number of shares of Common Stock issuable upon conversion of each share of Series C
                         Preferred Stock immediately prior to such Automatic Conversion Effective Time

</TABLE>

          and the Exercise Price per share of Common Stock shall be a price
          calculated as follows:

                           -6-
<PAGE>

<TABLE>
<S>              <C>     <C>
                 A   =   (B) (X) /Y

     where:      A   =   the Exercise Price per share of Common Stock upon and after such Automatic Conversion
                         Effective Time

                 B   =   the Exercise Price per share of Series C Preferred Stock immediately prior to such
                         Automatic Conversion Effective Time

                 X   =   the number of shares of Series C Preferred Stock purchasable under this Warrant
                         immediately prior to such Automatic Conversion Effective Time

                 Y   =   the number of shares of Common Stock purchasable under this Warrant upon and after such
                         Automatic Conversion Effective Time
</TABLE>

     Thereafter, the number of shares of Common Stock purchasable hereunder and
the Exercise Price per share shall be subject to adjustment for the types of
events described in Section 2 above that occur with respect to the Common Stock.

5.   Restrictions.  The Warrant Shares issuable u upon exercise of this Warrant
     ------------
are subject to the terms and provisions of a Voting Agreement among the
Corporation and certain stockholders of the Corporation. The Corporation shall
furnish a copy of such Voting Agreement to any registered holder of this Warrant
or such Warrant Shares upon written request and without charge. Any certificate
or certificates representing Warrant Shares issued upon exercise of this Warrant
shall contain a legend to the foregoing effect.

6.   Miscellaneous.
     -------------

     6.01  No Rights as Stockholder.  This Warrant shall not entitle the
           ------------------------
Warrantholder to any voting rights or any other rights as a stockholder of the
Corporation, but upon presentation of this Warrant with the subscription form
annexed duly executed and the tender of payment of the Exercise Price at the
office of the Corporation pursuant to the provisions of this Warrant, the
Warrantholder shall forthwith be deemed a stockholder of the Corporation in
respect of the shares of Series C Preferred Stock or Common Stock so subscribed
and paid for.

     6.02  Governing Law.  This Warrant shall be governed by, and construed
           -------------
and enforced in accordance with, the substantive laws of The Commonwealth of
Massachusetts, without regard to its principles of conflicts of laws.

     6.03  Fractional Shares.  No fractional shares or scrip representing
           -----------------
fractional shares shall be issued upon exercise of this Warrant.  If, upon
exercise of this Warrant, the Warrantholder would, except for the provisions of
this Subsection 6.03, be entitled to receive a fractional share of Series C
Preferred Stock or Common Stock, then the Corporation shall pay

                                      -7-
<PAGE>

the exercising Warrantholder in cash an amount equal to such fractional share
multiplied by the fair market value (as reasonably determined by the
Corporation's Board of Directors) of one share of Series C Preferred Stock or
Common Stock, as the case may be.

     6.04  Headings.  The headings in the Warrant are inserted for convenience
           --------
of reference only and shall not affect the interpretation of this Warrant.
Whenever from the context it appears appropriate, each term stated in either the
singular or plural shall include the singular and the plural, and pronouns
stated in either the masculine or the neuter gender shall include the masculine,
the feminine and the neuter.

     6.05  Substitution.  In case this Warrant shall be mutilated, lost, stolen
           ------------
or destroyed, the Corporation shall issue a new Warrant of like tenor and
denomination and deliver the same (a) in exchange and substitution for and upon
surrender and cancellation of any mutilated Warrant, or (b) in lieu of any
Warrant lost, stolen or destroyed, upon receipt of evidence satisfactory to the
Corporation of the loss, theft, or destruction of such Warrant (including a
reasonably detailed affidavit with respect to the circumstances of any loss,
theft or destruction), and an indemnity agreement reasonably satisfactory to the
Corporation.

     6.06  Modification.  This Warrant and any term hereof may be changed,
           ------------
waived, discharged or terminated only by an instrument in writing signed by the
party against which enforcement of such change, waiver, discharge or termination
is or may be sought.

     IN WITNESS WHEREOF, the Corporation has caused this Stock Purchase Warrant
to be signed by its President thereunto duly authorized and its corporate seal
to be hereunto affixed and attested by its Secretary.

Dated: ________________________          SEQUENOM,, INC

(Corporate Seal)

Attest:                                  By:___________________________
                                                  Its President

________________________________
Secretary

                                      -8-
<PAGE>

                           WARRANTHOLDER'S ACCEPTANCE
                           --------------------------

     The undersigned hereby accepts the foregoing warrant and agrees to the
terms and conditions thereof.


                                       WARRANTHOLDER


                                       By:____________________________
<PAGE>

                               SUBSCRIPTION FORM
                               -----------------

     The undersigned, the registered holder of the within Stock Purchase
Warrant, hereby irrevocably elects to exercise the purchase right represented by
such Warrant for, and to purchase thereunder, _______ shares of Series C
Convertible Preferred Stock, par value $.001 per share, of Sequenom, Inc., and
herewith makes payment of $ ____________ therefor and requests that the
certificates representing such shares be issued in the name of and delivered to
____________ and if such shares shall not include all of the shares issuable
under this Warrant, that a new Warrant of like tenor and date be delivered to
the undersigned for the shares not issued.


Dated:_______________________________  _______________________________
                                       Name of Registered Holder


                                       _______________________________
                                       Authorized Signature
<PAGE>

                               FORM OF ASSIGNMENT
                               ------------------

     For value received the undersigned hereby sells, assigns and transfers unto
________________________, whose address is __________________________________,
the within Stock Purchase Warrant with respect to _________ shares of Series C
Convertible Preferred Stock purchasable thereby, and does hereby irrevocably
constitute and appoint _______________ attorney to transfer the within Warrant
on the books of Sequenom, Inc. with full power of substitution in the premises.


Dated:_________________________        _______________________________
                                       Name of Registered Holder

In the presence of:


_______________________________        _______________________________
                                       Authorized Signature
<PAGE>

                                  EXHIBIT 4.1
                                  -----------

          Foreign Qualification; Certificate of Incorporation; By-Laws
          ------------------------------------------------------------

     The Corporation is qualified to do business in Massachusetts and
California.

     Copies of the Certificate of Incorporation (not including the Certificate
of Amendment contained in Exhibit 1) and By-Laws are attached hereto.
<PAGE>

                          CERTIFICATE OF INCORPORATION

                                       OF

                                 SEQUENOM, INC.

     FIRST:    The name of the corporation is Sequenom, Inc. (the
"Corporation").

     SECOND:   The address of the Corporation's registered office in the State
of Delaware is Corporation Trust Center, 1209 Orange Street, in the City of
Wilmington, County of New Castle 19801.  The name of its registered agent at
such address is The Corporation Trust Company.

     THIRD:    The nature of the business or purposes to be conducted or
promoted by the Corporation is to engage in any lawful act or activity for which
corporations may be organized under the General Corporation Law of Delaware.

     FOURTH:   The Corporation is authorized to issue one class of shares to be
designated "Common Stock".  The number of shares of Common Stock authorized to
be issued is Fifteen Million (15,000,000).  The Common Stock shall have a par
value of $0.001 per share, and the aggregate par value of all shares of Common
Stock shall be $15,000.

     FIFTH:    The Corporation is to have perpetual existence.

     SIXTH:    In furtherance and not in limitation of the powers conferred by
statute, the Board of Directors is expressly authorized to make, alter, amend or
repeal the Bylaws of the corporation.

     SEVENTH:  The number of directors which constitute the entire Board of
Directors of the Corporation shall be as specified in the Bylaws of the
Corporation.

     EIGHTH:   To the fullest extent permitted by the Delaware General
Corporation Law as the same exists or as may hereafter be amended, no director
of the Corporation shall be personally liable to the Corporation or its
stockholders for monetary damages for breach of fiduciary duty as a director.
Neither any amendment nor repeal of this Article Eighth, nor the adoption of any
provision of this Restated Certificate of Incorporation inconsistent with this
Article Eighth, shall eliminate or reduce the effect of this Article Eighth in
respect of any matter occurring, or any cause of action, suit or claim that, but
for this Article Eighth, would accrue or arise, prior to such amendment, repeal
or adoption of an inconsistent provision.

     NINTH:    The corporation reserves the right to amend, alter, change or
repeal any provision contained in this Certificate of Incorporation, in the
manner now or hereafter prescribed by statute, and all rights conferred upon
stockholders herein are granted subject to this reservation.
<PAGE>

     The undersigned incorporator hereby acknowledges that the foregoing
Certificate of Incorporation is his act and deed and that the facts stated
herein are true.

Dated: February  14, 1994                 /s/ Joe C. Sorenson
                                          -------------------
                                          Joe C. Sorenson
                                          Incorporator

                                          525 University Avenue
                                          14th Floor
                                          Palo Alto, California 94301

                                      2.
<PAGE>

                                 SEQUENOM, INC.

                            CERTIFICATE OF AMENDMENT

                                       OF

                          CERTIFICATE OF INCORPORATION

          Sequenom, Inc., a corporation organized and existing under and by
virtue of the General Corporation Law of the State of Delaware, DOES HEREBY
CERTIFY:

          FIRST: That the Board of Directors of Sequenom, Inc., by the unanimous
written consent of its members, filed with the minutes of the board, duly
adopted resolutions setting forth a proposed amendment to the Certificate of
Incorporation of said corporation, declaring said amendment to be advisable and
authorizing the officers of said corporation to solicit the approval of the
stockholders of said corporation for consideration thereof.  The resolution
setting forth the proposed amendment is as follows:

          RESOLVED:  That the Certificate of Incorporation of this corporation
          be amended by changing Article FOURTH thereof so that, as amended said
          Article shall be and read as follows:

          "The Corporation is authorized to issue one class of shares to be
          designated "Common Stock." The number of shares of Common Stock
          authorized to be issued is Two Million One Hundred Thousand
          (2,100,000).  The Common Stock shall have a value of $0.001 per share,
          and the aggregate par value of all shares of Common Stock shall be
          $2,100.  Upon the amendment of this article to read as herein set
          forth, each ten (10) outstanding shares of Common Stock shall be
          combined and converted into one (1) share."

          SECOND:  That thereafter, pursuant to resolution of its Board of
Directors, the written consents of the stockholders of said corporation were
solicited pursuant to authority to act without a meeting in accordance With
Section 228(a) of the General Corporation Law of
<PAGE>

Delaware and Section 2.11 of the bylaws of said corporation; and that the
stockholders unanimously consented to the amendment.

          THIRD:  That said amendment was duly adopted in accordance with the
provisions of Section 242 of the General Corporation Law of the State of
Delaware.

          IN WITNESS WHEREOF, said Sequenom, Inc. has caused this certificate to
be signed by Nola E. Masterson, its President, and attested by Robert E.
Patterson, its Secretary, this 23rd day of May, 1994.

                                      BY: /s/ Nola Masterson
                                          ------------------
                                          Nola E. Masterson,
President

ATTEST:


By: /s/ Robert Patterson
    --------------------
    Robert E. Patterson, Secretary

                                      2.
<PAGE>

                            CERTIFICATE OF AMENDMENT
                                       OF
                          CERTIFICATE OF INCORPORATION
                               OF SEQUENOM, INC.

     Sequenom, Inc., a corporation organized and existing under and by virtue of
the General Corporation Law of the State of Delaware, DOES HEREBY CERTIFY:

     FIRST:    That the Board of Directors of said corporation by unanimous
               written consent duly adopted resolutions proposing and declaring
               advisable that the Certificate of Incorporation of said
               corporation be amended and that such amendment be submitted to
               the stockholders of the Corporation for their consideration, as
               follows:

                    RESOLVED:  That the Board of Directors of this Corporation
                               recommends and deems it advisable that the
                               Certificate of Incorporation of this Corporation,
                               as heretofore amended, be further amended by
                               deleting Article FOURTH thereof and substituting
                               for said Article FOURTH the new Article FOURTH
                               set forth on Exhibit A attached hereto; and
                                            ---------

                    RESOLVED:  That the aforesaid proposed amendment be
                               submitted to the stockholders of the Corporation
                               for their consideration; and

                    RESOLVED:  That following the approval by the stockholders
                               of the aforesaid amendment as required by law,
                               the officers of this Corporation be, and they
                               hereby are, and each of them hereby is,
                               authorized and directed (i) to prepare, execute
                               and file with the Secretary of State of the State
                               of Delaware a Certificate of Amendment setting
                               forth the aforesaid amendment in the form
                               approved by the stockholders and (ii) to take any
                               and all other actions necessary, desirable or
                               convenient to give effect to the aforesaid
                               amendment or otherwise to carry out the purposes
                               of the foregoing Resolutions.

     SECOND:   That in lieu of a meeting and vote of stockholders, the
               stockholders have given written consent to said amendments in
               accordance with the provisions of section 228 of the General
               Corporation Law of the State of Delaware, and written notice of
               the adoption of the amendments has been given as provided in
               section 228 of the General Corporation Law of the State of
               Delaware to every stockholder entitled to such notice.
<PAGE>

     THIRD:    That the aforesaid amendments were duly adopted in accordance
               with the applicable provisions of sections 228 and 242 of the
               General Corporation Law of the State of Delaware.

     IN WITNESS WHEREOF, said Sequenom, Inc. has caused this certificate to be
signed by Russell D. Hays, its President, and attested by Robert E. Patterson,
its Secretary, this 7th day of March, 1995.

ATTEST:                            SEQUENOM, INC.



By:  /s/ illegible                 By:  /s/ illegible
     ---------------                    ---------------
     Secretary                          President

                                      -2-
<PAGE>

                                   EXHIBIT A
                                   ---------

FOURTH:  The total number of shares of all classes of stock which the
- ------
Corporation has authority to issue is 4,399,000 shares, consisting of 2,301,000
shares of Common Stock, par value $.001 per share (the "Common Stock"), and
2,098,000 shares of Series A Convertible Preferred Stock, par value $.001 per
share (the "Series A Preferred Stock"), amounting to an aggregate par value of
$4,399.

     The powers, preferences and rights, and the qualifications, limitations or
restrictions thereof, in respect of each class or series of stock of the
Corporation shall be as follows:

     Section 1.  Liquidation Rights.
     ---------   ------------------

          (a) Treatment at Liquidation, Dissolution or Winding Up.  In the event
              ---------------------------------------------------
of any liquidation, dissolution or winding up of the affairs of the Corporation,
whether voluntary or involuntary, the holders of each share of the Series A
Preferred Stock shall be entitled to be paid first out of the assets of the
Corporation available for distribution to holders of the Corporation's capital
stock of all classes an amount equal to the greater of:

               (i) $0.50 per share of Series A Preferred Stock (which amount
     shall be subject to equitable adjustment whenever there shall occur a stock
     dividend, stock split, combination of shares, reclassification or other
     similar event with respect to the Series A Preferred Stock) plus all
     dividends declared but unpaid thereon, to and including the date full
     payment shall be tendered to the holders of the Series A Preferred Stock
     with respect to such liquidation, .dissolution or winding up, or

               (ii) such amount per share of Series A Preferred Stock as would
     have been payable had all shares of Series A Preferred Stock been converted
     to Common Stock immediately prior to such event of liquidation, dissolution
     or winding up pursuant to the provisions of Section 2 hereof, plus all
     dividends declared but unpaid on each share of Series A Preferred Stock to
     and including the date full payment shall be tendered to the holders of the
     Series A Preferred Stock with respect to such liquidation, dissolution or
     winding up.

     If the assets of the Corporation shall be insufficient to permit the
payment in full to the holders of the Series A Preferred Stock of all amounts
distributable to them under this Subsection 1(a), then the entire assets of the
Corporation available for such distribution shall be distributed ratably among
the holders of the Series A Preferred Stock in proportion to the full
preferential amount each such holder is otherwise entitled to receive.

     After such payments shall have been made in full to the holders of the
Series A Preferred Stock or funds necessary for such payments shall have been
set aside by the Corporation in trust for the account of holders of Series A
Preferred Stock so as to be available for such payments, the remaining assets
available for distribution shall be distributed among the holders of the Common
Stock ratably in proportion to the number of shares of Common Stock held by
them.
<PAGE>

     Upon conversion of shares of Series A Preferred Stock into shares of Common
Stock pursuant to Section 2 below, the holder of such Common Stock shall not be
entitled to any preferential payment or distribution in case of any liquidation,
dissolution or winding up, but shall share ratably in any distribution of the
assets of the Corporation to all the holders of Common Stock.

     The amounts payable with respect to shares of Series A Preferred Stock
under this Section 1 are sometimes hereinafter referred to as "Liquidation
Payments."

          (b) Distributions Other than Cash.  Whenever the distribution provided
              -----------------------------
for in this Section 1 shall be payable in property other than cash, the value of
such distribution shall be the fair market value of such property as determined
in good faith by the Board of Directors of the Corporation.

          (c) Merger as Liquidation, etc.  The merger or consolidation of the
              --------------------------
Corporation into or with another corporation (except one in which the holders of
capital stock of the Corporation immediately prior to such merger or
consolidation continue to hold at least eighty percent (80%) in voting power of
the capital stock of the surviving corporation, in which case the provisions of
Subsection 2(h) shall apply), or the sale of all or substantially all of the
assets of the Corporation, shall be deemed to be a liquidation, dissolution or
winding up of the affairs of the Corporation for purposes of this Section 1
unless the holders of at least eighty percent (80%) of the then outstanding
shares of Series A Preferred Stock elect to the contrary by giving written
notice thereof to the Corporation at least three days before the effective date
of such event.  If such notice is given, the provisions of Subsection 2(h) shall
apply.  Any amounts received by the holders of Series A Preferred Stock as a
result of such merger or consolidation shall be deemed to be applied toward, and
all consideration received by the Corporation in such asset sale together with
all other available assets of the Corporation shall be distributed toward, the
Liquidation Payments attributable to such shares of Series A Preferred Stock
unless such election is made

          (d) Notice.  Written notice of any proposed liquidation, dissolution
              ------
or winding up of the affairs of the Corporation (including any merger,
consolidation or sale of assets which may be deemed to be a liquidation,
dissolution or winding up of the affairs of the Corporation under Subsection
l(c)), stating a payment date, the amount of the Liquidation Payments and the
place where said Liquidation Payments shall be payable, shall be given by first
class mail, postage prepaid, or by telex to non-U.S. residents, not less than
twenty (20) days prior to the payment date stated therein, to the holders of
record of Series A Preferred Stock, such notice to be addressed to each such
holder at its address as shown by the records of the Corporation.

     Section 2.  Conversion.  The holders of the Series A Preferred Stock shall
     ---------   ----------
have conversion rights as follows (the "Conversion Rights"):

          (a) Right to Convert; Conversion Price.  Each share of Series A
              ----------------------------------
Preferred Stock shall be convertible, without the payment of any additional
consideration by the holder thereof and at the option of the holder thereof, at
any time after the date of issuance of such share, at the office of the
Corporation or any transfer agent for the Series A Preferred Stock, into such
number of fully paid and nonassessable shares of Common Stock as is determined
by

                                      -2-
<PAGE>

dividing $0.50 by the Conversion Price, determined as hereinafter provided,
in effect at the time of conversion.  The Conversion Price at which shares of
Common Stock shall be deliverable upon conversion without the payment of any
additional consideration by the holder of Series A Preferred Stock (the
"Conversion Price") shall initially be $0.50 per share of Common Stock.  Such
initial Conversion Price shall be subject to adjustment, in order to adjust the
number of shares of Common Stock into which the Series A Preferred Stock is
convertible, as hereinafter provided.

          (b) Automatic Conversion.  Each share of Series A Preferred Stock
              --------------------
shall automatically be converted into shares of Common Stock at the then
effective Conversion Price upon:

               (i) the closing of a firm commitment underwritten public offering
     pursuant to an effective registration statement under the Securities Act of
     1933, as amended, covering the offer and sale of Common Stock for the
     account of the Corporation to the public at an initial public offering
     price per share not less than $2.50 (as adjusted pursuant to Subsection
     2(e)(vi) hereof to reflect any stock dividends, distributions,
     combinations, reclassifications or other like transactions effected by the
     Corporation in respect of its Common Stock) and with gross proceeds to the
     Corporation of not less than $10,000,000 (in the event of which offering,
     the person(s) entitled to receive the Common Stock issuable upon such
     conversion of the Series A Preferred Stock shall not be deemed to have
     converted that Series A Preferred Stock until the closing of such
     offering); or

               (ii) the written election of the holders of not less than eighty
     percent (80%) of the then outstanding shares of Series A Preferred Stock to
     require such mandatory conversion.

          (c) Mechanics of Mandatory Conversions.  Upon the occurrence of an
              ----------------------------------
event specified in Subsection 2(b), the Series A Preferred Stock shall be
converted automatically without any further action by the holders of such shares
and whether or not the certificates representing such shares are surrendered to
the Corporation or its transfer agent; provided, however, that all holders of
shares of Series A Preferred Stock shall be given written notice of the
occurrence of an event specified in Subsection 2(b) including the date such
event occurred (the "Mandatory Conversion Date"), and the Corporation shall not
be obligated to issue certificates evidencing the shares of Common Stock
issuable upon such conversion unless certificates evidencing such shares of the
Series A Preferred Stock being converted are either delivered to the corporation
or its transfer agent, or the holder notifies the Corporation or any transfer
agent that such certificates have been lost, stolen, or destroyed and executes
an agreement satisfactory to the Corporation to indemnify the Corporation from
any loss incurred by it in connection therewith and, if the Corporation so
elects, provides an appropriate indemnity bond.  On the Mandatory Conversion
Date, all rights with respect to the Series A Preferred Stock so converted shall
terminate, except any of the rights of the holder thereof, upon surrender of the
holder's certificate or certificates therefor, to receive certificates for the
number of shares of Common Stock into which such Series A Preferred Stock has
been converted, together with cash in an amount equal to all dividends declared
but unpaid on, and any and all other amounts owing with respect to, the shares
of Series A Preferred Stock converted to and including the time of

                                      -3-
<PAGE>

conversion. Upon the automatic conversion of the Series A Preferred Stock, the
holders of such Series A Preferred Stock shall surrender the certificates
representing such shares at the office of the Corporation or of its transfer
agent. If so required by the Corporation, certificates surrendered for
conversion shall be endorsed or accompanied by written instrument, or
instruments of transfer, in form satisfactory to the Corporation, duly executed
by the registered holder or by the holder's attorney duly authorized in writing.
Upon surrender of such certificates there shall be issued and delivered to such
holder, promptly at such office and in the holder's name as shown on such
surrendered certificate or certificates, a certificate or certificates for the
number of shares of Common Stock into which the shares of the Series A Preferred
Stock surrendered were convertible on the date on which such automatic
conversion occurred, together with cash in an amount equal to all dividends
declared but unpaid on, and any and all other amounts owing with respect to, the
shares of Series A Preferred Stock converted to and including the time of
conversion. No fractional share of Common Stock shall be issued upon the
mandatory conversion of the Series A Preferred Stock. In lieu of any fractional
share to which the holder would otherwise be entitled, the Corporation shall pay
cash equal to such fraction multiplied by the then effective Conversion Price.

          (d) Mechanics of Optional Conversions.  Before any holder of Series A
              ---------------------------------
Preferred Stock shall be entitled to convert the same into shares of Common
Stock, the holder shall surrender the certificate or certificates therefor at
the office of the Corporation or of any transfer agent for the Series A
Preferred Stock, and shall give written notice to the Corporation at such office
that the holder elects to convert the same and shall state therein the holder's
name or the name or names of the holder's nominees in which the holder wishes
the certificate or certificates for shares of Common Stock to be issued.  On the
date of conversion, all rights with respect to the Series A Preferred Stock so
converted shall terminate, except any of the rights of the holder thereof, upon
surrender of the holder's certificate or certificates therefor, to receive
certificates for the number of shares of Common Stock into which such Series A
Preferred Stock has been converted and cash in an amount equal to all dividends
declared but unpaid thereon and any and all other amounts owing with respect
thereto at such time.  If so required by the Corporation, certificates
surrendered for conversion shall be endorsed or accompanied by written
instrument or instruments of transfer, in form satisfactory to the Corporation,
duly executed by the registered holder or by the holder's attorney duly
authorized in writing.  No fractional share of Common Stock shall be issued upon
the optional conversion of the Series A Preferred Stock.  In lieu of any
fractional share to which the holder would otherwise be entitled, the
Corporation shall pay cash equal to such fraction multiplied by the then
effective Conversion Price.  The Corporation shall, as soon as practicable after
surrender of the certificate or certificates for conversion, issue and deliver
at such office to such holder of Series A Preferred Stock, or to the holder's
nominee or nominees, a certificate or certificates for the number of shares of
Common Stock to which the holder shall be entitled as aforesaid, together with
cash in lieu of any fraction of a share and cash in an amount equal to all
dividends declared but unpaid thereon and any and all other amounts owing with
respect thereto at such time.  Such conversion shall be deemed to have been made
immediately prior to the close of business on the date of such surrender of the
shares of Series A Preferred Stock to be converted, and the person or persons
entitled to receive the shares of Common Stock issuable upon conversion shall be
treated for all purposes as the record holder or holders of such shares of
Common Stock on such date.

                                      -4-
<PAGE>

          (e) Adjustments to Conversion Price for Diluting Issues.
              ---------------------------------------------------

               (i) Special Definitions.  For purposes of this Subsection 2(e),
                   -------------------
     the following definitions shall apply:

                    (1) "Option" shall mean rights, options or warrants to
                         ------
          subscribe for, purchase or otherwise acquire either Common Stock or
          Convertible Securities.

                    (2) "Original Issue Date" shall mean the first date on which
                         -------------------
          a share of Series A Preferred Stock was issued.

                    (3) "Convertible Securities" shall mean any evidences of
                         ----------------------
          indebtedness, shares of capital stock (other than Common Stock) or
          other securities directly or indirectly convertible into or
          exchangeable for Common Stock.

                    (4) "Additional Shares of Common Stock" shall mean all
                         ---------------------------------
          shares of Common Stock issued (or, pursuant to Subsection 2(e)(iii),
          deemed to be issued) by the Corporation after the original Issue Date,
          other than:

                         (A) shares of Series A Preferred Stock issuable upon
               exercise of Options outstanding on the Original Issue Date;

                         (B) up to 200,000 shares of Series A Preferred Stock
               issuable upon exercise of Options which may be issued in
               connection with equipment lease financing provided to the
               Corporation by Comdisco, Inc. or its affiliates;

                         (C) shares of Common Stock issued or issuable upon
               conversion of shares of Series A Preferred Stock;

                         (D) shares of Common Stock issued or issuable to
               officers or employees or directors of, or consultants to, the
               Corporation pursuant to a stock purchase or option plan or other
               employee stock bonus arrangement (collectively, the "Plans")
               approved by the Board of Directors; and

                         (E) shares of Common Stock issued as a dividend or
               distribution on Series A Preferred Stock.

               (ii) No Adjustment of Conversion Price.  Except as set forth in
                    ---------------------------------
     Subsection 2(e)(vi), no adjustment in the number of shares of Common Stock
     into which the Series A Preferred Stock is convertible shall be made, by
     adjustment in the Conversion Price in respect of the issuance of Additional
     Shares of Common Stock, unless the consideration per share for an
     Additional Share of Common Stock (determined pursuant to Subsection
     2(e)(v)) issued or deemed to be issued by the Corporation is less

                                      -5-
<PAGE>

     than the Conversion Price in effect on the date of, and immediately prior
     to, the issue of such Additional Share.

               (iii)  Issue of Securities Deemed Issue of Additional Shares of
                      --------------------------------------------------------
     Common Stock.
     ------------

                    (1) Options and Convertible Securities.  In the event the
                        ----------------------------------
          Corporation at any time or from time to time after the Original Issue
          Date shall issue any Options or Convertible Securities or shall fix a
          record date for the determination of holders of any class of
          securities entitled to receive any such options or Convertible
          Securities, then the maximum number of shares (as set forth in the
          instrument relating thereto without regard to any provisions contained
          therein for a subsequent adjustment of such number) of Common Stock
          issuable upon the exercise of such Options or, in the case of
          Convertible Securities and Options therefor, the conversion or
          exchange of such Convertible Securities, shall be deemed to be
          Additional Shares of Common Stock issued as of the time of such issue
          or, in case such a record date shall have been fixed, as of the close
          of business on such record date, provided that in any such case in
          which Additional Shares of Common Stock are deemed to be issued:

                         (A) no further adjustment in the Conversion Price shall
               be made upon the subsequent issue of Convertible Securities or
               shares of Common Stock upon the exercise of such Options or
               conversion or exchange of such Convertible Securities;

                         (B) if such Options or Convertible Securities by their
               terms provide, with the passage of time or otherwise, for any
               increase in the consideration payable to the corporation, or
               decrease in the number of shares of Common Stock issuable, upon
               the exercise, conversion or exchange thereof, the Conversion
               Price computed upon the original issue thereof (or upon the
               occurrence of a record date with respect thereto), and any
               subsequent adjustments based thereon, shall, upon any such
               increase or decrease becoming effective, be recomputed to reflect
               such increase or decrease insofar as it affects such Options or
               the rights of conversion or exchange under such Convertible
               Securities;

                         (C) upon the expiration of any such Options or any
               rights of conversion or exchange under such Convertible
               Securities which shall not have been exercised, the Conversion
               Price computed upon the original issue thereof (or upon the
               occurrence of a record date with respect thereto), and any
               subsequent adjustments based thereon, shall, upon such
               expiration, be recomputed as if:

                              (I) In the case of Convertible Securities or
                    Options for Common Stock the only Additional Shares of
                    Common Stock issued were the shares of Common Stock, if any,
                    actually issued upon the exercise of such Options or the
                    conversion

                                      -6-
<PAGE>

                    or exchange of such Convertible Securities and the
                    consideration received therefor was the consideration
                    actually received by the Corporation for the issue of all
                    such Options, whether or not exercised, plus the
                    consideration actually received by the Corporation upon such
                    exercise, or for the issue of all such Convertible
                    Securities which were actually converted or exchanged, plus
                    the additional consideration, if any, actually received by
                    the Corporation upon such conversion or exchange; and

                              (II) in the case of Options for Convertible
                    Securities only the Convertible Securities, if any, actually
                    issued upon the exercise thereof were issued at the time of
                    issue of such Options, and the consideration received by the
                    Corporation for the Additional Shares of Common Stock deemed
                    to have been then issued was the consideration actually
                    received by the Corporation for the issue of all such
                    Options, whether or not exercised, plus the consideration
                    deemed to have been received by the Corporation (determined
                    pursuant to Subsection 2(e)(v)) upon the issue of the
                    Convertible Securities with respect to which such Options
                    were actually exercised;

                         (D) no readjustment pursuant to clause (B) or (C) above
               shall have the effect of increasing the Conversion Price to an
               amount which exceeds the lower of (i) the Conversion Price on the
               original adjustment date, or (ii) the Conversion Price that would
               have resulted from any issuance of Additional Shares of Common
               Stock between the original adjustment date and such readjustment
               date;

                         (E) in the case of any Options which expire by their
               terms not more than 30 days after the date of issue thereof, no
               adjustment of the Conversion Price shall be made until the
               expiration or exercise of all such Options, whereupon such
               adjustment shall be made in the same manner provided in clause
               (C) above; and

                         (F) if such record date shall have been fixed and such
               Options or Convertible Securities are not issued on the date
               fixed therefor, the adjustment previously made in the Conversion
               Price which became effective on such record date shall be
               cancelled as of the close of business on such record date, and
               thereafter the Conversion Price shall be adjusted pursuant to
               this Subsection 2(e)(iii) as of the actual date of their
               issuance.

                    (2) Stock Dividends, Stock Distributions and Subdivisions.
                        -----------------------------------------------------
          In the event the Corporation at any time or from time to time after
          the Original Issue Date shall declare or pay any dividend or make any
          other distribution on the Common Stock payable in Common Stock or
          effect a subdivision of the outstanding shares of Common Stock (by
          reclassification or otherwise than by

                                      -7-
<PAGE>

          payment of a dividend in Common Stock), then and in any such event,
          Additional Shares of Common Stock shall be deemed to have been issued:

                         (A) in the case of any such dividend or distribution,
               immediately after the close of business on the record date for
               the determination of holders of any class of securities entitled
               to receive such dividend or distribution, or

                         (B) in the case of any such subdivision, at the close
               of business on the date immediately prior to the date upon which
               such corporate action becomes effective.

                    If such record date shall have been fixed and no part of
          such dividend shall have been paid on the date fixed therefor, the
          adjustment previously made in the Conversion Price which became
          effective on such record date shall be cancelled as of the close of
          business on such record date, and thereafter the Conversion Price
          shall be adjusted pursuant to this Section 2(e)(iii) as of the time of
          actual payment of such dividend.

               (iv) Adjustment of Conversion Price Upon Issuance of Additional
                    ----------------------------------------------------------
     Shares of Common Stock.  In the event that at any time or from time to time
     ----------------------
     after the Original Issue Date, the Corporation shall issue Additional
     Shares of Common Stock (including, without limitation, Additional Shares of
     Common Stock deemed to be issued pursuant to Subsection 2(e)(iii)(1) but
     excluding Additional Shares of Common Stock deemed to be issued pursuant to
     Subsection 2(e)(iii)(2), which event is dealt with in Subsection
     2(e)(vi)(1)), without consideration or for a consideration per share less
     than the applicable Conversion Price in effect on the date of and
     immediately prior to such issue, then and in such event, such Conversion
     Price shall be reduced, concurrently with such issue, to a price
     (calculated to the nearest cent) determined in accordance with the
     following formula:

                       (P1) (Ql) + (P2) (Q2)
               NPC =  ______________________
                          Q1     +     Q2
     where:

          NPC =   New Conversion Price.

          P1 =    Conversion Price of Series A Preferred Stock in effect
                  immediately prior to new issue.

          Q1 =    Number of shares of Common Stock outstanding, or deemed to be
                  outstanding as set forth below, immediately prior to such
                  issue.

          P2      Weighted average price per share received by the Corporation
                  upon such issue.

                                      -8-
<PAGE>

          Q2      Number of shares of Common Stock issued, or deemed to have
                  been issued, in the subject transaction.

     provided that for the purpose of this Subsection 2(e)(iv), all shares of
     -------------
     Common Stock issuable upon exercise or conversion of any Options or
     Convertible Securities outstanding immediately prior to such issue shall be
     deemed to be outstanding, and immediately after any Additional Shares of
     Common Stock are deemed issued pursuant to Subsection 2(e)(iii), such
     Additional Shares of Common Stock shall be deemed to be outstanding; and
     provided further, that the applicable Conversion Price shall not be so
     ----------------
     reduced at any time if the amount of such reduction would be an amount less
     than $.0l, but any such amount shall be carried forward and reduction with
     respect thereto made at the time of and together with any subsequent
     reduction which, together with such amount and any other amount or amounts
     so carried forward, shall aggregate $.0l or more.

               (v) Determination of Consideration.  For purposes of this
                   ------------------------------
     Subsection 2(e), the consideration received by the Corporation for the
     issue of any Additional Shares of Common Stock shall be computed as
     follows:

                    (1) Cash and Property: Such consideration shall:
                             -----------------

                         (A) insofar as it consists of cash, be computed at the
               aggregate amounts of cash received by the Corporation excluding
               amounts paid or payable for accrued interest or accrued
               dividends;

                         (B) insofar as it consists of property other than cash,
               be computed at the fair value thereof at the time of such issue,
               as determined in good faith by the Board of Directors; and

                         (C) in the event Additional Shares of Common Stock are
               issued together with other shares or securities or other assets
               of the Corporation for consideration which covers both, be the
               proportion of such consideration so received, computed as
               provided in clauses (A) and (B) above, as determined in good
               faith by the Board of Directors.

                    (2) Options and Convertible Securities.  The consideration
                        ----------------------------------
          per share received by the Corporation for Additional Shares of Common
          Stock deemed to have been issued pursuant to Subsection 2(e)(iii)(1),
          relating to Options and Convertible Securities, shall be determined by
          dividing (x) the total amount, if any, received or receivable by the
          Corporation as consideration for the issue of such Options or
          Convertible Securities, plus the minimum aggregate amount of
          additional consideration (as set forth in the instruments relating
          thereto, without regard to any provision contained therein for a
          subsequent adjustment of such consideration) payable to the
          Corporation upon the exercise of such Options or the conversion or
          exchange of such Convertible Securities, or in the case of Options for
          Convertible Securities, the exercise of such Options for Convertible
          Securities and the conversion or exchange of such

                                      -9-
<PAGE>

          Convertible Securities, by (y) the maximum number of shares of Common
          Stock (as set forth in the instruments relating thereto, without
          regard to any provision contained therein for a subsequent adjustment
          of such number) issuable upon the exercise of such Options or the
          conversion or exchange of such Convertible Securities.

               (vi) Adjustment for Dividends, Distributions, Subdivisions,
                    ------------------------------------------------------
     Combinations or Consolidations of Common Stock.
     ----------------------------------------------

                    (1) Stock Dividends, Distributions or Subdivisions.  In the
                        ----------------------------------------------
          event the Corporation shall be deemed to issue Additional Shares of
          Common Stock pursuant to Subsection 2(e)(iii)(2) in a stock dividend,
          stock distribution or subdivision, the Conversion Price in effect
          immediately before such deemed issuance shall, concurrently with the
          effectiveness of such deemed issuance, be proportionately decreased.

                    (2) Combinations or Consolidations.  In the event the
                        ------------------------------
          outstanding shares of Common Stock shall be combined or consolidated,
          by reclassification or otherwise, into a lesser number of shares of
          Common Stock, the Conversion Price in effect immediately prior to such
          combination or consolidation shall, concurrently with the
          effectiveness of such combination or consolidation, be proportionately
          increased.

          (f) Adjustments for Certain Dividends and Distributions.  In the event
              ---------------------------------------------------
that at any time or from time to time after the original Issue Date the
Corporation shall make or issue, or fix a record date for the determination of
holders of Common Stock entitled to receive, a dividend or other distribution
payable in securities of the Corporation other than shares of Common Stock, then
and in each such event provision shall be made so that the holders of Series A
Preferred Stock shall receive upon conversion thereof in addition to the number
of shares of Common Stock receivable thereupon, the amount of securities of the
Corporation that they would have received had their Series A Preferred Stock
been converted into Common Stock on the date of such event and had they
thereafter, during the period from the date of such event to and including the
conversion date, retained such securities receivable by them as aforesaid during
such period, giving application during such period to all adjustments called for
herein.

          (g) Adjustment for Reclassification, Exchange, or Substitution.  In
              ----------------------------------------------------------
the event that at any time or from time to time after the Original Issue Date,
the Common Stock issuable upon the conversion of the Series A Preferred Stock
shall be changed into the same or a different number of shares of any class or
classes of stock, whether by capital reorganization, reclassification, or
otherwise (other than a subdivision or combination of shares or stock dividend
provided for above, or a merger, consolidation, or sale of assets provided for
below), then and in each such event the holder of each such share of Series A
Preferred Stock shall have the right thereafter to convert such share into the
kind and amount of shares of stock and other securities and property receivable
upon such reorganization, reclassification, or other change, by holders of the
number of shares of Common Stock into which such shares of Series A Preferred
Stock might have been converted immediately prior to such reorganization,
reclassification, or change, all subject to further adjustment as provided
herein.

                                     -10-
<PAGE>

          (h) Adjustment for Merger, Consolidation or Sale of Assets.  In the
              ------------------------------------------------------
event that at any time or from time to time after the Original Issue Date, the
Corporation shall merge or consolidate with or into another entity or sell all
or substantially all of its assets (other than a consolidation, merger or sale
which is treated as a liquidation pursuant to Subsection 1(c)), each share of
Series A Preferred Stock shall thereafter be convertible into the kind and
amount of shares of stock or other securities or property to which a holder of
the number of shares of Common Stock of the Corporation deliverable upon
conversion of such Series A Preferred Stock would have been entitled upon such
consolidation, merger or sale; and, in such case, appropriate adjustment (as
determined in good faith by the Board of Directors) shall be made in the
application of the provisions set forth in this Section 2 with respect to the
rights and interest thereafter of the holders of Series A Preferred Stock, to
the end that the provisions set forth in this Section 2 (including provisions
with respect to changes in and other adjustments of the Conversion Price) shall
thereafter be applicable, as nearly as reasonably may be, in relation to any
shares of stock or other property thereafter deliverable upon the conversion of
the Series A Preferred Stock.

          (i) No Impairment.  The Corporation shall not, by amendment of its
              -------------
Certificate of Incorporation or through any reorganization, transfer of assets,
consolidation, merger, dissolution, issue or sale of securities or any other
voluntary action, avoid or seek to avoid the observance or performance of any of
the terms to be observed or performed hereunder by the Corporation but shall at
all times in good faith assist in the carrying out of all the provisions of this
Section 2 and in the taking of all such action as may be necessary or
appropriate in order to protect the Conversion Rights of the holders of the
Series A Preferred Stock against impairment.

          (j) Certificate as to Adjustments.  Upon the occurrence of each
              -----------------------------
adjustment or readjustment of the Conversion Price pursuant to this Section 2,
the Corporation at its expense shall promptly compute such adjustment or
readjustment in accordance with the terms hereof and furnish to each affected
holder of Series A Preferred Stock a certificate setting forth such adjustment
or readjustment and showing in detail the facts upon which such adjustment or
readjustment is based.  The Corporation shall, upon the written request at any
time of any affected holder of Series A Preferred Stock, furnish or cause to be
furnished to such holder a like certificate setting forth (i) such adjustments
and readjustments, (ii) the Conversion Price at the time in effect, and (iii)
the number of shares of Common Stock and the amount, if any, of other property
which at the time would be received upon the conversion of each share of Series
A Preferred Stock.

          (k) Notices of Record Date.  In the event of any taking by the
              ----------------------
Corporation of a record of the holders of any class of securities for the
purpose of determining the holders thereof who are entitled to receive any
dividend (other than a cash dividend which is the same as cash dividends paid in
previous quarters) or other distribution, the Corporation shall mail to each
holder of Series A Preferred Stock at least ten (10) days prior to such record
date a notice specifying the date on which any such record is to be taken for
the purpose of such dividend or distribution.

          (1) Common Stock Reserved.  The Corporation shall reserve and keep
              ---------------------
available out of its authorized but unissued Common Stock such number of shares
of Common

                                     -11-
<PAGE>

Stock as shall from time to time be sufficient to effect conversion of
the Series A Preferred Stock.

          (m) Certain Taxes.  The Corporation shall pay any issue or transfer
              -------------
taxes payable in connection with the conversion of the Series A Preferred Stock,
provided, however, that the corporation shall not be required to pay any tax
which may be payable in respect of any transfer to a name other than that of the
holder of the Series A Preferred Stock.

          (n) Closing of Books.  The Corporation shall at no time close its
              ----------------
transfer books against the transfer of any Series A Preferred Stock or of any
shares of Common Stock issued or issuable upon the conversion of any shares of
Series A Preferred Stock in any manner which interferes with the timely
conversion or transfer of such Series A Preferred Stock or Common Stock.

     Section 3.  Voting Rights.  Except as otherwise required by law or
     ---------   -------------
hereinafter set forth, the holders of Series A Preferred Stock shall be entitled
to notice of any meeting of stockholders and shall vote together with the
holders of Common Stock as a single class upon any matter submitted to the
stockholders for a vote, on the following basis:

               (a) Holders of Common Stock shall have one vote per share; and

               (b)  Holders of Series A Preferred Stock shall have that number
     of votes per share as is equal to the number of shares of Common Stock
     (including fractions of a share) into which each such share of Series A
     Preferred Stock held by such holder could be converted on the date for
     determination of stockholders entitled to vote at the meeting or on the
     date of any written consent.

     With respect to all questions as to which, under law, stockholders are
required to vote by classes, the Series A Preferred Stock shall vote together as
a single class separately from the Common Stock.

     Section 4.  Dividends.  Dividends may be declared and paid on Common Stock
     ---------   ---------
and Series A Preferred Stock from funds lawfully available therefor as and when
determined by the Board of Directors of the Corporation.  If, when and as
dividends are declared and paid on shares of Common Stock, the Corporation shall
declare and pay at the same time to each holder of Series A Preferred Stock, a
dividend equal to the dividend which would have been payable to such holder if
the shares of Series A Preferred Stock held by such holder had been converted
into Common Stock on the record date for the determination of holders of Common
Stock entitled to receive such dividend.

     Section 5.  No Reissuance of Preferred Stock.  No share or shares of Series
     ---------   --------------------------------
A Preferred Stock acquired by the Corporation by reason of redemption, purchase,
conversion or otherwise shall be reissued, and all such shares shall be
cancelled, retired and eliminated from the shares which the Corporation shall be
authorized to issue.

     Section 6.  Residual Rights.  All rights accruing to the outstanding shares
     ---------   ---------------
of the Corporation not expressly provided for to the contrary herein shall be
vested in the Common Stock.

                                     -12-
<PAGE>

                            CERTIFICATE OF AMENDMENT
                                       OF
                          CERTIFICATE OF INCORPORATION
                               OF SEQUENOM, INC.

     Sequenom, Inc., a corporation organized and existing under and by virtue of
the General Corporation Law of the State of Delaware, DOES HEREBY CERTIFY:

     FIRST:   That at a meeting of the Board of Directors of said corporation
              resolutions were duly adopted proposing and declaring advisable
              that the Certificate of Incorporation of said corporation be
              amended and that such amendment be submitted to the stockholders
              of the Corporation for their consideration, as follows:

                    RESOLVED:  That the Board of Directors of this Corporation
                               recommends and deems it advisable that the
                               Certificate of Incorporation of this Corporation,
                               as heretofore amended, be further amended by
                               deleting Article FOURTH thereof and substituting
                               for said Article FOURTH the new Article FOURTH
                               set forth on Exhibit A attached hereto; and
                                            ---------

                    RESOLVED:  That the aforesaid proposed amendment be
                               submitted to the stockholders of the Corporation
                               for their consideration; and

                    RESOLVED:  That following the approval by the stockholders
                               of the aforesaid amendment as required by law,
                               the officers of this Corporation be, and they
                               hereby are, and each of them hereby is,
                               authorized and directed (i) to prepare, execute
                               and file with the Secretary of State of the State
                               of Delaware a Certificate of Amendment setting
                               forth the aforesaid amendment in the form
                               approved by the stockholders and (ii) to take any
                               and all other actions necessary, desirable or
                               convenient to give affect to the aforesaid
                               amendment or otherwise to carry out the purposes
                               of the foregoing Resolutions.

     SECOND:  That in lieu of a meeting and vote of stockholders, the
              stockholders have given written consent to said amendments in
              accordance with the provisions of section 228 of the General
              Corporation Law of the state of Delaware, and written notice of
              the adoption of the amendments has been given as provided in
              section 228 of the General Corporation Law of the State of
              Delaware to every stockholder entitled to such notice.
<PAGE>

     THIRD:   That the aforesaid amendments were duly adopted in accordance with
              the applicable provisions of sections 228 and 242 of the General
              Corporation Law of the State of Delaware.

     IN WITNESS WHEREOF, said Sequenom, Inc. has caused this certificate to be
signed by Randall R. Lunn, its President, and attested by David R. Pierson, its
Secretary, this 22nd, day of December, 1995.

ATTEST:                                   SEQUENOM, INC.



By: /s/ illegible                         By: /s/ illegible
    ---------------                           ---------------
    Secretary                                 President

                                      -2-
<PAGE>

                                   EXHIBIT A
                                   ---------


FOURTH:  The total number of shares of all classes of
- ------
stock which the Corporation has authority to issue is 10,753,366 shares,
consisting of 5,726,700 shares of Common Stock, par value $.001 per share (the
"Common Stock"), 1,650, 000 shares of Series A Convertible Preferred Stock, par
value $.001 per share (the "Series A Preferred Stock"), and 3,376,666 shares of
Series B Convertible Preferred Stock, par value $.001 per share (the "Series B
Preferred Stock", and, together with the Series A Preferred Stock, the
"Preferred Stock"), amounting to an aggregate par value of $10,753.37.

     The powers, preferences and rights, and the qualifications, limitations or
restrictions thereof, in respect of each class or series of stock of the
Corporation shall be as follows:

     Section 1.  Liquidation Rights.
     ---------   ------------------

          (a)  In the event of any liquidation, dissolution or winding up of the
affairs of the Corporation, whether voluntary or involuntary, the holders of
each share of the Series B Preferred Stock shall be entitled to be paid first
out of the assets of the Corporation available for distribution to holders of
the Corporation's capital stock of all classes an amount equal to the greater
of:

               (i)   $1.50 per share of series B Preferred Stock (which amount
     shall be subject to equitable adjustment whenever there shall occur a stock
     dividend, stock split, combination of shares, reclassification or other
     similar event with respect to the Series B Preferred Stock) plus all
     dividends declared but unpaid thereon, to and including the date full
     payment shall be tendered to the holders of the Series B Preferred Stock
     with respect to such liquidation, dissolution or winding up, or

               (ii)  such amount per share of Series B Preferred Stock as would
     have been payable had all shares of Series B Preferred Stock been converted
     to Common Stock immediately prior to such event of liquidation, dissolution
     or winding up pursuant to the provisions of Section 2 hereof, plus all
     dividends declared but unpaid on each shares of Series B Preferred Stock to
     and including the date full payment shall be tendered to the holders of the
     Series B Preferred Stock with respect to such liquidation, dissolution or
     winding up.

     If the assets of the Corporation shall be insufficient to permit the
payment in full to the holders of the Series B Preferred Stock of all amounts so
distributable to them, then the entire assets of the Corporation available for
such distribution shall be distributed ratably among the holders of the Series B
Preferred Stock in proportion to the full preferential amount each such holder
is otherwise entitled to receive.

     After such payments shall have been made in full to the holders of the
Series B Preferred Stock or funds necessary for such payments shall have been
set aside by the Corporation in trust for the account of holders of Series B
Preferred Stock so as to be available for such payments, the holders of each
share of the Series A Preferred Stock shall be entitled to be paid out of the
<PAGE>

assets of the Corporation available for distribution to holders of the
Corporation's capital stock of all classes an amount equal to the greater of:

               (i)   $0.50 per share of Series A Preferred Stock (which amount
     shall be subject to equitable adjustment whenever there shall occur a stock
     dividend, stock split, combination of shares, reclassification or other
     similar event with respect to the Series A Preferred Stock) plus all
     dividends declared but unpaid thereon, to and including the date full
     payment shall be tendered to the holders of the Series A Preferred Stock
     with respect to such liquidation, dissolution or winding up, or

               (ii)  such amount par share of Series A Preferred Stock as would
     have been payable had all shares of Series A Preferred Stock been converted
     to Common Stock immediately prior to such event of liquidation, dissolution
     or winding up pursuant to the provisions of Section 2 hereof, plus all
     dividends declared but unpaid on each share of Series A Preferred Stock to
     and including the date full payment shall be tendered to the holders of the
     Series A Preferred Stock with respect to such liquidation, dissolution or
     winding up.

     If the assets of the Corporation shall be insufficient to permit the
payment in full to the holders of the Series A Preferred Stock of all amounts so
distributable to them, then the entire remaining assets of the Corporation
available for such distribution shall be distributed ratably among the holders
of the Series A Preferred Stock in proportion to the full preferential amount
each such holder is otherwise entitled to receive.

     After such payments shall have been made in full to the holders of the
Series B Preferred Stock and to the holders of the Series A Preferred Stock, or
funds necessary for such payments shall have been set aside by the Corporation
in trust for the account of holders of Preferred Stock so as to be available for
such payments, the remaining assets available for distribution shall be
distributed among the holders of the Common Stock ratably in proportion to the
number of shares of Common Stock held by them.

     Upon conversion of shares of Series B Preferred Stock or Series A Preferred
Stock into shares of Common Stock pursuant to Section 2 below, the holder of
such Common Stock shall not be entitled to any preferential payment or
distribution in case of any liquidation, dissolution or winding up, but shall
share ratably in any distribution of the assets of the Corporation to all the
holders of Common Stock.

     The amounts payable with respect to shares of Series B Preferred Stock and
Series A Preferred Stock under this Section l(a) are sometimes hereinafter
referred to as "Series B Liquidation Payments" and "Series A Liquidation
Payments," respectively, and together are sometimes hereinafter referred to as
the "Liquidation Payments."

          (b) Distributions Other than Cash.  Whenever the distributions
              -----------------------------
provided for in this Section 1 shall be payable in property other than cash, the
value of such distributions shall be the fair market value of such property as
determined in good faith by the Board of Directors of the Corporation.

                                      -2-
<PAGE>

          (c) Merger as Liquidation, etc.  The merger or consolidation of the
              --------------------------
Corporation into or with another corporation (except one in which the holders of
capital stock of the Corporation immediately prior to such merger or
consolidation continue to hold at least eighty percent (80%) in voting power of
the capital stock of the surviving corporation, in which case the provisions of
Subsection 2(h) shall apply), or the sale of all or substantially all of the
assets of the Corporation, shall be deemed to be a liquidation, dissolution or
winding up of the affairs of the Corporation for purposes of this Section 1 with
respect to the Series B Preferred Stock unless the holders of at least eighty-
five percent (85%) of the then outstanding shares of the Series B Preferred
Stock elect to the contrary, and with respect to the Series A Preferred Stock
unless the holders of at least eighty percent (80%) of the then outstanding
shares of the Series A Preferred Stock elect to the contrary, such election in
either case to be made by giving written notice thereof to the Corporation at
least three days before the effective date of such event.  If such notice is
given with respect to the Series B Preferred Stock or the Series A Preferred
Stock, the provisions of Subsection 2(h) shall apply to such Series B Preferred
Stock or Series A Preferred Stock, as the case may be.  Unless such election is
made, any amounts received by the holders of the Series B Preferred Stock and
the Series A Preferred Stock as a result of such merger or consolidation shall
be deemed to be applied toward, and all consideration received by the
Corporation in such asset sale together with all other available assets of the
Corporation shall be distributed toward, the Liquidation Payments attributable
to such shares of Series B Preferred Stock and Series A Preferred Stock,
respectively, in the order of preference set forth in Section 1.

          (d) Notice.  Written notice of any proposed liquidation, dissolution
              ------
or winding up of the affairs of the Corporation (including any merger,
consolidation or sale of assets which may be deemed to be a liquidation,
dissolution or winding up of the affairs of the Corporation under Subsection
l(c)), stating a payment date, the amount of the Liquidation Payments and the
place where said Liquidation Payments shall be payable, shall be given by first
class mail, postage prepaid, or by telex to non-U.S. residents, not less than
twenty (20) days prior to the payment date stated therein, to the holders of
record of the Series B Preferred Stock and the Series A Preferred Stock, such
notice to be addressed to each such holder at its address an shown by the
records of the Corporation.

     Section 2.  Conversion.  The holders of Preferred Stock shall have
     ---------   ----------
conversion rights as follows (the "Conversion Rights"):

          (a) Right to Convert; Conversion Price.  Each share of Preferred Stock
              ----------------------------------
shall be convertible, without the payment of any additional consideration by the
holder thereof and at the option of the holder thereof, at any time after the
data of issuance of such share, at the office of the Corporation or any transfer
agent for the Preferred Stock, into such number of fully paid and nonassessable
shares of Common Stock as is determined in accordance with the following:

               (i)   in the case of the Series B Preferred Stock, by dividing
     $1.50 by the Series B Conversion Price determined as hereinafter provided,
     in affect at the time of conversion.  The Conversion Price at which shares
     of Common Stock shall be deliverable upon conversion of Series B Preferred
     Stock without the payment of any additional consideration by the holder
     thereof (the "Series B Conversion Price") shall initially be $1.50 per
     share of Common Stock.  Such initial Series B Conversion Price shall be

                                      -3-
<PAGE>

     subject to adjustment, in order to adjust the number of shares of Common
     Stock into which the Series B Preferred Stock in convertible, as
     hereinafter provided.

               (ii)  in the case of the Series A Preferred Stock, by dividing
     $0.50 by the Series A Conversion Price, determined as hereinafter provided,
     in effect at the time of conversion.  The Conversion Price at which shares
     of Common Stock shall be deliverable upon conversion of Series A Preferred
     Stock without the payment of any additional consideration by the holder
     thereof (the "Series A Conversion Price") shall initially be $0.50 per
     share of Common Stock.  Such initial Series A Conversion Price shall be
     subject to adjustment, in order to adjust the number of shares of Common
     Stock into which the Series A Preferred Stock is convertible, as
     hereinafter provided.

          (b) Automatic Conversion.  Each share of Series B Preferred Stock
              --------------------
shall automatically be converted into shares of Common Stock at the applicable
Series B conversion Price then in effect upon:

               (i)   the closing of a firm commitment underwritten public
     offering pursuant to an effective registration statement under the
     Securities Act of 1933, an amended, covering the offer and sale of Common
     Stock for the account of the Corporation to the public at an offering price
     per share (prior to underwriter commissions and discounts) of not less than
     $4.50 (an adjusted pursuant to Subsection 2 (e) (vi) hereof to reflect any
     stock dividends, distributions, combinations, reclassifications or other
     like transactions effected by the Corporation in respect of its Common
     Stock) and with gross proceeds to the Corporation of not less than
     $10,000,000 (in the event of which offering, the person(s) entitled to
     receive the Common Stock issuable upon such conversion of the Series B
     Preferred Stock shall not be deemed to have converted that Series B
     Preferred Stock until the closing of such offering); or

               (ii)  the written election of the holders of not less than
     eighty-five percent (85%) of the then outstanding shares of the Series B
     Preferred Stock to require such mandatory conversion.

     Each share of Series A Preferred Stock shall automatically be converted
into shares of Common Stock at the applicable Series A Conversion Price then in
effect upon:

               (i)   the closing of a firm commitment underwritten public
     offering pursuant to an effective registration statement under the
     Securities Act of 1933, as amended, covering the offer and sale of Common
     Stock for the account of the Corporation to the public at an offering price
     per share (prior to underwriter commissions and discounts) of not less than
     $2.50 (as adjusted pursuant to Subsection 2 (e) (vi) , hereof to reflect
     any stock dividends, distributions, combinations, reclassifications or
     other like transactions effected by the Corporation in respect of its
     Common Stock) and with gross proceeds to the Corporation of not lose than
     $10,000,000 (in the event of which offering, the person(s) entitled to
     receive the Common Stock issuable upon such conversion of the Series A
     Preferred Stock shall not be deemed to have converted that Series A
     Preferred Stock until the closing of such offering); or

                                      -4-
<PAGE>

               (ii)  the written election of the holders of not less than eighty
     percent (80%) of the then outstanding shares of the Series A Preferred
     Stock to require such mandatory conversion.

          (c) Mechanics of Automatic Conversions.  Upon the occurrence of an
              ----------------------------------
event specified in Subsection 2(b), the Series B Preferred Stock or the Series A
Preferred Stock, as applicable, or both, shall be converted automatically
without any further action by the holders of such shares and whether or not the
certificates representing such shares are surrendered to the Corporation or its
transfer agent; provided, however, that all holders of shares of Preferred Stock
being converted shall be given written notice of the occurrence of an event
specified in Subsection 2(b) including the date such event occurred (the
"Mandatory Conversion Date"), and the Corporation shall not be obligated to
issue certificates evidencing the shares of Common Stock issuable upon such
conversion unless certificates evidencing such shares of the Preferred Stock
being converted are either delivered to the Corporation or its transfer agent,
or the holder notifies the Corporation or any transfer agent that such
certificates have been lost, stolen, or destroyed and executes an agreement
satisfactory to the Corporation to indemnify the Corporation from any loss
incurred by it in connection therewith and, if the Corporation so elects,
provides an appropriate indemnity bond.  On the Mandatory Conversion Date, all
rights with respect to the Preferred Stock so converted shall terminate, except
any of the rights of the holder thereof, upon surrender of the holder's
certificate or certificates therefor, to receive certificates for the number of
shares of Common Stock into which such Preferred Stock has been converted,
together with cash in an amount equal to all dividends declared but unpaid on,
and any and all other amounts owing with respect to, the shares of Preferred
Stock converted to and including the time of conversion.  Upon the automatic
conversion of the Preferred Stock, the holders of such Preferred Stock shall
surrender the certificates representing such shares at the office of the
Corporation or of its transfer agent.  If so required by the Corporation,
certificates surrendered for conversion shall be endorsed or accompanied by
written instrument or instruments of transfer, in form satisfactory to the
Corporation, duly executed by the registered holder or by the holder's attorney
duly authorized in writing.  Upon surrender of such certificates there shall be
issued and delivered to such holder, promptly at such office and in the holder's
name as shown on such surrendered certificate or certificates, a certificate or
certificates for the number of shares of Common Stock into which the shares of
the Preferred Stock surrendered were convertible on the date on which such
automatic conversion occurred, together with cash in an amount equal to all
dividends declared but unpaid on, and any and all other amounts owing with
respect to, the shares of Preferred Stock converted to and including the time of
conversion.  No fractional share of Common Stock shall be issued upon the
mandatory conversion of the Preferred Stock.  In lieu of any fractional share to
which the holder would otherwise be entitled, the Corporation shall pay cash
equal to such fraction multiplied by the applicable Conversion Price then in
effect.

          (d) Mechanics of Optional Conversions.  Before any holder of Preferred
              ---------------------------------
Stock shall be entitled to convert the same into shares of Common Stock, the
holder shall surrender the certificate or certificates therefor at the office of
the Corporation or of any transfer agent for the Preferred Stock, and shall give
written notice to the Corporation at such office that the holder elects to
convert the same and shall state therein the holder's name or the name or names
of the holder's nominees in which the holder wishes the certificate or
certificates for shares of Common Stock to be issued.  On the date of
conversion, all rights with respect to the Preferred Stock so

                                      -5-
<PAGE>

converted shall terminate, except any of the rights of the holder thereof, upon
surrender of the holder's certificate or certificates therefor, to receive
certificates for the number of shares of Common Stock into which such Preferred
Stock has been converted and cash in an amount equal to all dividends declared
but unpaid thereon and any and all other amounts owing with respect thereto at
such time. If so required by the Corporation, certificates surrendered for
conversion shall be endorsed or accompanied by written instrument or instruments
of transfer, in form satisfactory to the Corporation, duly executed by the
registered holder or by the holder's attorney duly authorized in writing. No
fractional share of Common Stock shall be issued upon the optional conversion of
Preferred Stock. In lieu of any fractional share to which the holder would
otherwise be entitled, the Corporation shall pay cash equal to such fraction
multiplied by the applicable Conversion Price then in effect. The Corporation
shall, as soon as practicable after surrender of the certificate or certificates
for conversion, issue and deliver at such office to such holder of Preferred
Stock, or to the holder's nominee or nominees, a certificate or certificates for
the number of shares of Common Stock to which the holder shall be entitled as
aforesaid, together with cash in lieu of any fraction of a share and cash in an
amount equal to all dividends declared but unpaid thereon and any and all other
amounts owing with respect thereto at such time. Such conversion shall be deemed
to have been made immediately prior to the close of business on the date of such
surrender of the shares of Preferred Stock to be converted, and the person or
persons entitled to receive the shares of Common Stock issuable upon conversion
shall be treated for all purposes as the record holder or holders of such shares
of Common Stock on such date.

          (e)  Adjustments to Conversion Price for Diluting Issues.
               ---------------------------------------------------

               (i)   Special Definitions.  For purposes of this Subsection 2(e),
                     -------------------
     the following definitions shall apply:

                    (1) "Option" shall mean rights, options or warrants to
                         ------
          subscribe for, purchase or otherwise acquire either Common Stock or
          Convertible Securities.

                    (2) "Original Issue Date" shall mean, with respect to the
                         -------------------
          Series A Preferred Stock, the first date on which a share of Series A
          Preferred Stock was issued, and shall mean, with respect to the Series
          B Preferred Stock, the first of such Additional Share.

               (iii) Issue of Securities Deemed Issue of Additional Shares
                     -----------------------------------------------------
     of Common Stock.
     ---------------

                     (1) Options and Convertible Securities.  In the event the
                         ----------------------------------
          Corporation at any time or from time to time after the Original Issue
          Date shall issue any Options or Convertible Securities or shall fix a
          record date for the determination of holders of any class of
          securities entitled to receive any such Options or Convertible
          Securities, then the maximum number of shares (as act forth in the
          instrument relating thereto without regard to any provisions contained
          therein for a subsequent adjustment of such number) of Common Stock
          issuable upon the exercise of such Options or, in the case of
          Convertible Securities and

                                      -6-
<PAGE>

          Options therefor, the conversion or exchange of such Convertible
          Securities, shall be deemed to be Additional Shares of Common Stock
          issued as of the time of such issue or, in case such a record date
          shall have been fixed, as of the close of business on such record
          date, provided that in any such case in which Additional Shares of
          Common Stock are deemed to be issued:

                         (A) no further adjustment in the Series B Conversion
               Price or the Series A Conversion Price shall be made upon the
               subsequent issue of Convertible Securities or shares of Common
               Stock upon the exercise of such Options or conversion or exchange
               of such Convertible Securities;

                         (B) if such Options or Convertible Securities by their
               terms provide, with the passage of time or otherwise, for any
               increase in the consideration payable to the Corporation, or
               decrease in the number of shares of Common Stock issuable, upon
               the exercise, conversion or exchange thereof, the Series B
               Conversion Price and the Series A Conversion Price computed upon
               the original issue thereof (or upon the occurrence of a record
               date with respect thereto), and any subsequent adjustments based
               thereon, shall, upon any such increase or decrease becoming
               effective, be recomputed to reflect such increase or decrease
               insofar as it affects such Options or the rights of conversion or
               exchange under such Convertible Securities;

                         (C) upon the expiration of any such Options or any
               rights of conversion or exchange under such Convertible
               Securities which shall not have been exercised, the Series B
               Conversion Price and the Series A Conversion Price computed upon
               the original issue thereof (or upon the occurrence of a record
               date with respect thereto), and any subsequent adjustments based
               thereon, shall, upon such expiration, be recomputed as if:

                              (I) In the case of Convertible Securities or
                    Options for common stock the only Additional Shares of
                    Common Stock issued were the shares of Common Stock, if any,
                    actually issued upon the exercise of such Options or the
                    conversion or exchange of such Convertible Securities and
                    the consideration received therefor was the consideration
                    actually received by the Corporation for the issue of all
                    such Options, whether or not exercised, plus the
                    consideration actually received by the Corporation upon such
                    exercise, or for the issue of all such Convertible
                    Securities which were actually converted or exchanged, plus
                    the additional consideration, if any, actually received by
                    the Corporation upon such conversion or exchange; and

                                      -7-
<PAGE>

                              (II) in the case of Options for Convertible
                    Securities only the Convertible Securities, if any, actually
                    issued upon the exercise thereof were issued at the time of
                    issue of such Options, and the consideration received by the
                    Corporation for the Additional Shares of Common Stock deemed
                    to have been then issued was the consideration actually
                    received by the Corporation for the issue of all such
                    Options, whether or not exercised, plus the consideration
                    deemed to have been received by the Corporation (determined
                    pursuant to Subsection 2 (e) (v)) upon the issue of the
                    Convertible securities with respect to which such Options
                    were actually exercised;

                         (D) no readjustment pursuant to clause (B) or (C) above
               shall have the effect of increasing the Series B Conversion Price
               or the Series A Conversion Price to an amount which exceeds the
               lower of (i) the respective Conversion Price on the original
               adjustment date, or (ii) the respective Conversion Price that
               would have resulted from any issuance of Additional Shares of
               Common Stock between the original adjustment date and such
               readjustment date;

                         (E) in the case of any Options which expire by their
               terms not more than 30 days after the date of issue thereof, no
               adjustment of the Series B Conversion Price or the Series A
               Conversion Price shall be made until the expiration or exercise
               of all such Options, whereupon such adjustment shall be made in
               the same manner provided in clause (C) above; and

                         (F) if such record date shall have been fixed and such-
               Options or Convertible Securities are not issued on the date
               fixed therefor, the adjustment previously made in the Series B
               Conversion Price and the Series A Conversion Price which became
               effective on such record date shall be cancelled as of the close
               of business an such record date, and thereafter the respective
               Conversion Prices shall be adjusted pursuant to this Subsection
               2(e)(iii) as of the actual date of their issuance.

                    (2) Stock Dividends, Stock Distribution and Subdivisions.
                        ----------------------------------------------------
          In the event the Corporation at any time or from time to time after
          the Original Issue Date shall declare or pay any dividend or make any
          other distribution on the Common Stock payable in Common Stock or
          effect a subdivision of the outstanding shares of Common Stock (by
          reclassification or otherwise than by payment of a dividend in Common
          Stock), then and in any such event, Additional Shares of Common Stock
          shall be deemed to have been issued:

                         (A) in the case of any such dividend or distribution,
               immediately after the close of business on the record date for
               the determination of holders of any class of securities entitled
               to receive such dividend or distribution, or

                                      -8-
<PAGE>

                         (B) in the case of any such subdivision, at the close
               of business on the date immediately prior to the date upon which
               such. corporate action becomes effective.

                         If such record date shall have been fixed and no part
          of such dividend shall have been paid on the date fixed therefor, the
          adjustment previously made in the Series B Conversion Price and the
          Series A Conversion Price which became effective on such record date
          shall be cancelled as of the close of business on such record date,
          and thereafter the respective Conversion Prices shall be adjusted
          pursuant to this Section 2 (e) (iii) as of the time of actual payment
          of such dividend.

               (iv) Adjustment of Conversion Price Upon Issuance of Additional
                    ----------------------------------------------------------
     Shares of Common Stock.  In the event that at any time or from time to time
     ----------------------
     after the Original Issue Date, the Corporation shall issue Additional
     Shares of Common Stock (including, without limitation, Additional Shares of
     Common Stock deemed to be issued pursuant to Subsection 2 (e) (iii) (1) but
     excluding Additional Shares of Common Stock deemed to be issued pursuant to
     Subsection 2(e) (iii) (2), which event is dealt with in subsection 2 (e)
     (vi) (1), without consideration or for a consideration per share less than
     the applicable Series B Conversion Price or Series A Conversion Price in
     effect on the date of and immediately prior to such issue, then and in such
     event, such Series B Conversion Price or Series A Conversion Price, as the
     case may be, shall be reduced, concurrently with such issue, to a price
     (calculated to the nearest cent) determined in accordance with the
     following formula:

<TABLE>
<CAPTION>
                              (P1)  (Ql)  +  (P2)  (Q2)
                 NPC =        _________________________
                                  Q1      +      Q2
<S>                             <C>     <C>
     where:

          NCP    =       New Series B Conversion Price or Series A Conversion
                         Price, as applicable.

          P1     =       Series B Conversion Price or Series A Conversion Price,
                         an applicable, in affect immediately prior to new
                         issue.

          Ql     =       Number of shares of Common Stock outstanding, or deemed
                         to be outstanding as set forth below, immediately prior
                         to such issue.

          P2     =       Weighted average price per share received by the
                         Corporation upon such issue.

          Q2     =       Number of shares of Common Stock issued, or deemed to
                         have been issued, in the subject transaction.
</TABLE>

     provided that for the purpose of this Subsection 2 (e) (iv), all shares of
     --------
     Common Stock issuable upon exercise or conversion of any Options or
     Convertible Securities outstanding immediately prior to such issue shall be
     deemed to be outstanding, and

                                      -9-
<PAGE>

     immediately after any Additional Shares of Common Stock are deemed issued
     pursuant to Subsection 2 (e) (iii), such Additional Shares of Common Stock
     shall be deemed to be outstanding; and provided further, that the
                                            -------- -------
     applicable Conversion Price shall not be so reduced at any time if the
     amount of such reduction would be an amount less than $.01, but any such
     amount shall be carried forward and reduction with respect thereto made at
     the time of and together with any subsequent reduction which, together with
     such amount and any other amount or amounts so carried forward, shall
     aggregate $.0l or more.

               (v) Determination of Consideration.  For purposes of this
                   ------------------------------
     Subsection 2(e), the consideration received by the Corporation for the
     issue of any Additional Shares of Common stock shall be computed as
     follows:

                         (1) Cash and Property.  Such consideration shall:
                             -----------------

                             (A) insofar as it consists of cash; be computed at
               the aggregate amounts of cash received by the Corporation
               excluding amounts paid or payable for accrued interest or accrued
               dividends;

                             (B) insofar as it consists of property other than
               cash, be computed at the fair value thereof at the time of such
               issue, as determined in good faith by the Board of Directors; and

                             (C) in the event Additional Shares of Common Stock
               are issued together with other shares or securities or other
               assets of the Corporation for consideration which covers both, be
               the proportion of such consideration so received, computed as
               provided in clauses (A) and (B) above, as determined in good
               faith by the Board of Directors.

                    (2) Options and Convertible Securities.  The consideration
                        ----------------------------------
          per share received by the Corporation for Additional shares of Common
          Stock deemed to have been issued pursuant to Subsection 2 (e) (iii)
          (1) , relating to Options and Convertible securities, shall be
          determined by dividing (x) the total amount, if any, received or
          receivable by the Corporation as consideration for the issue of such
          Options or Convertible Securities, plus the minimum aggregate amount
          of additional consideration (as set forth in the instruments relating
          thereto, without regard to any provision contained therein for a
          subsequent adjustment of such consideration) payable to the
          Corporation upon the exercise of such Options or the conversion or
          exchange of such Convertible Securities, or in the case of Options for
          Convertible Securities, the exercise of such Options for Convertible
          Securities and the conversion or exchange of such Convertible
          Securities, by (y) the maximum number of shares of Common Stock (as
          set forth in the instruments relating thereto, without regard to any
          provision contained therein for a subsequent adjustment of such
          number) issuable upon the exercise of such Options or the conversion
          or exchange of such Convertible Securities.

                                     -10-
<PAGE>

               (vi) Adjustment for Dividends, Distributions, Subdivisions,
                    ------------------------------------------------------
     Combinations or Consolidations of Common Stock.
     ----------------------------------------------

                    (1) Stock Dividends, Distributions or Subdivisions.  In the
                        ----------------------------------------------
          event the Corporation shall be deemed to issue Additional Shares of
          Common Stock pursuant to Subsection 2(e)(iii)(2) in a stock dividend,
          stock distribution or subdivision, the Series B Conversion Price and
          the Series A Conversion Price in effect immediately before such deemed
          issuance shall, concurrently with the effectiveness of such deemed
          issuance, be proportionately decreased.

                    (2) Combinations or Consolidations.  In the event the
                        ------------------------------
          outstanding shares of Common Stock shall be combined or consolidated,
          by reclassification or otherwise, into a lesser number of shares of
          Common Stock, the Series B Conversion Price and the Series A
          Conversion Price in effect immediately prior to such combination or
          consolidation shall, concurrently with the effectiveness of such
          combination or consolidation, be proportionately increased.

          (f) Adjustments for Certain Dividends and Distributions.  In the event
              ---------------------------------------------------
that at any time or from time to time after the Original Issue Date the
Corporation shall make or issue, or fix a record date for the determination of
holders of Common Stock entitled to receive, a dividend or other distribution
payable in securities of the Corporation other than shares of Common Stock, then
and in each such event provision shall be made so that the holders of Preferred
Stock shall receive upon conversion thereof in addition to the number of shares
of Common Stock receivable thereupon, the amount of securities of the
Corporation that they would have received had their Preferred Stock been
converted into Common Stock an the date of such event and had they thereafter,
during the period from the date of such event to and including the conversion
date, retained such securities receivable by them as aforesaid during such
period, giving application during such period to all adjustments called for
herein.

          (g) Adjustment for Reclassification, Exchange, or Substitution.  In
              ----------------------------------------------------------
the event that at any time or from time to time after the Original Issue Date,
the Common Stock issuable upon the conversion of Preferred Stock shall be
changed into the same or a different number of shares of any class or classes of
stock, whether by capital reorganization, reclassification, or otherwise (other
than a subdivision or combination of shares or stock dividend provided for
above, or a merger, consolidation, or sale of assets provided for below), then
and in each such event the holder of any share or shares of Preferred Stock
shall have the right thereafter to convert such shares into the kind and amount
of shares of stock and other securities and property receivable upon such
reorganization, reclassification, or other change, by the holder of a number of
shares of Common Stock equal to the number of shares of Common Stock into which
such shares of Preferred Stock might have been converted immediately prior to
such reorganization, reclassification, or change, all subject to further
adjustment as provided herein.

          (h) Adjustment for Merger, Consolidation or Sale of Assets.  In the
              ------------------------------------------------------
event that at any time or from time to time after the Original Issue Date, the
Corporation shall merge or consolidate with or into another entity or sell all
or substantially all of its assets, each share of Preferred Stock as to which
such consolidation, merger or sale is not treated as a liquidation

                                     -11-
<PAGE>

under Subsection l(c) shall thereafter be convertible into the kind and amount
of shares of stock or other securities or property to which a holder of the
number of shares of Common Stock of the Corporation deliverable upon conversion
of such Preferred Stock would have been entitled to receive upon such
consolidation, merger or sale; and, in such case, appropriate adjustment (as
determined in good faith by the Board of Directors) shall be made in the
application of the provisions set forth in this Section 2 with respect to the
rights and interest thereafter of the holders of Preferred Stock, to the end
that the provisions set forth in this Section 2 (including provisions with
respect to changes in and other adjustments of the Conversion Price) shall
thereafter be applicable, as nearly an reasonably may be, in relation to any
shares of stock or other property thereafter deliverable upon the conversion of
Preferred Stock.

          (i) No Impairment.  The corporation shall not, by amendment of its
              -------------
Certificate of Incorporation or through any reorganization, transfer of assets,
consolidation, merger, dissolution, issue or sale of securities or any other
voluntary action, avoid or seek to avoid the observance or performance of any of
the terms to be observed or performed hereunder by the Corporation but shall at
all times in good faith assist in the carrying out of all the provisions of this
Section 2 and in the taking of all such action as may be necessary or
appropriate in order to protect the Conversion Rights of the holders of
Preferred Stock against impairment.

          (j) Certificate as to Adjustment.  Upon the occurrence of each
              ----------------------------
adjustment or readjustment of the Series B Conversion Price or the Series A
Conversion Price pursuant to this Section 2, the Corporation at its expense
shall promptly compute such adjustment or readjustment in accordance with the
terms hereof and furnish to each affected holder of Preferred Stock a
certificate setting forth such adjustment or readjustment and showing in detail
the facts upon which such adjustment or readjustment is based.  The Corporation
shall, upon the written request at any time of any affected holder of Preferred
Stock, furnish or cause to be furnished to such holder a like certificate
setting forth (i) such adjustments and readjustments, (ii) the Conversion Price
at the time in effect, and (iii) the number of shares of Common Stock and the
amount, if any, of other property which at the time would be received upon the
conversion of each share of Preferred Stock.

          (k) Notices of Record Date.  In the event of any taking by the
              ----------------------
Corporation of a record of the holders of any class of securities for the
purpose of determining the holders thereof who are entitled to receive any
dividend (other than a cash dividend which is the same as cash dividends paid in
previous quarters) or other distribution, the Corporation shall mail to each
holder of Preferred Stock at least ten (10) days prior to such record date a
notice specifying the date on which any such record is to be taken for the
purpose of such dividend or distribution.

          (1) Common Stock Reserved.  The Corporation shall reserve and keep
              ---------------------
available out of its authorized but unissued Common Stock such number of shares
of Common Stock as shall from time to time be sufficient to affect conversion of
the Preferred Stock.

          (m) Certain Taxes.  The Corporation shall pay any issue or transfer
              -------------
taxes payable in connection with this conversion of Preferred Stock, provided,
however, that the Corporation shall not be required to pay any tax which may be
payable in respect of any transfer to a name other than that of the holder of
the Preferred Stock.

                                     -12-
<PAGE>

          (n) Closing of Books.  The Corporation shall at no time close its
              ----------------
transfer books against the transfer of any Preferred Stock or of any shares of
Common Stock issued or issuable upon the conversion of any shares of Preferred
Stock in any manner which interferes with the timely conversion or transfer of
such Preferred Stock or Common Stock.

     Section 3.  Restrictions.
     ---------   ------------

          (a) At any time when shares of Preferred Stock are outstanding, except
where the vote of the holders of a greater number of shares of the Corporation
is required by law or by this Certificate of Incorporation, and in addition to
any other vote required by law or this Certificate of Incorporation, without the
affirmative vote of the holders of at least sixty percent (60%) of the then
outstanding shares of Preferred Stock (with calculations based upon the number
of shares of Common Stock into which such shares of Preferred Stock are then
convertible), voting collectively as a single class, the Corporation will not:

               (i)    consent to any liquidation, dissolution or winding up of
     the Corporation or merge or consolidate with or into any other entity or
     entities;

               (ii)   sell, abandon, transfer, lease or otherwise dispose of all
     or any substantially portion of its properties and other assets; or

               (iii)  amend this Certificate of Incorporation or the
     Corporation's By-Laws.

          (b) At any time when shares of Series B Preferred Stock are
outstanding, except where the vote of the holders of a greater number of shares
of the Corporation is required by law or by this Certificate of Incorporation,
and in addition to any other vote required by law or this Certificate of
Incorporation, without the affirmative vote of the holders of at least eighty-
five percent (85%) of the then outstanding shares of Series B Convertible
Preferred Stock, the Corporation will not:

               (i)    amend, alter or change the designation or any preferences,
     voting powers, qualifications, or special or relative rights or privileges
     of the Series B Convertible Preferred Stock in a manner adverse to the
     interests of the holders of the Series B Convertible Preferred Stock in any
     material respect;

               (ii)   increase the authorized number of shares of Series B
     Preferred Stock;

               (iii)  create or authorize the creation of any additional series
     of shares of stock unless such series ranks junior to the Series B
     Convertible Preferred Stock as to both dividends and the distribution of
     assets on the liquidation, dissolution, winding up or insolvency of the
     Corporation, or increase the authorized amount of any other class or series
     of shares of stock unless the same ranks junior to the Series B Convertible
     Preferred Stock as to dividends and the distribution of assets on the
     liquidation, dissolution, winding up or insolvency of the Corporation, or
     create or authorize any obligation or security convertible into shares of
     Series B Convertible Preferred Stock or into shares of any other class or
     series of shares of stock unless the same ranks junior to

                                     -13-
<PAGE>

     the Series B Convertible Preferred Stock as to dividends and the
     distribution of assets on the liquidation, dissolution, winding up or
     insolvency of the Corporation, whether any such creation, authorization or
     increase shall be by means of amendment to this Certificate of
     Incorporation or by merger, consolidation or otherwise;

          (c) At any time when shares of Series A Preferred Stock are
outstanding, except where the vote of the holders of a greater number of shares
of the Corporation in required by law or by this Certificate of Incorporation,
and in addition to any other vote required by law or this Certificate of
Incorporation, without the affirmative vote of the holders of at least sixty
percent (60%) of the then outstanding shares of Series A Convertible Preferred
Stock, the Corporation will not:

               (i)    amend, alter or change the designation or any preferences,
     voting powers, qualifications, or special or relative rights or privileges
     of the Series A Convertible Preferred Stock in a manner adverse to the
     interests of the holders of the Series A Convertible Preferred Stock in any
     material respect;

               (ii)   increase the authorized number of shares of Series A
     Preferred Stock;

               (iii)  create or authorize the creation of any additional series
     of shares of stock unless such series ranks junior to the Series A
     Convertible Preferred Stock as to both dividends and the distribution of
     assets on the liquidation, dissolution, winding up or insolvency of the
     corporation, or increase the authorized amount of any other class or series
     of shares of stock unless the same ranks junior to the Series A Convertible
     Preferred Stock as to dividends and the distribution of assets on the
     liquidation, dissolution, winding up or insolvency of the Corporation, or
     create or authorize any obligation or security convertible into shares of
     Series A Convertible Preferred Stock or into shares of any other class or
     series of shares of stock unless the same ranks junior to the Series A
     Convertible Preferred Stock as to dividends and the distribution of assets
     on the liquidation, dissolution, winding up or insolvency of the
     Corporation, whether any such creation, authorization or increase shall be
     by means of amendment to this Certificate of Incorporation or by merger,
     consolidation or otherwise.

     Section 4.  Voting Rights.  Except as otherwise required by law or
                 -------------
hereinafter set forth, the holders of Preferred Stock shall be entitled to
notice of any meeting of stockholders and shall vote together with the holders
of Common Stock as a single class upon any matter submitted to the stockholders
for a vote, on the following basis:

          (a) Holders of Common Stock shall have one vote per share; and

          (b) Holders of Preferred Stock shall have that number of votes per
share as is equal to the number of shares of Common Stock (including fractions
of a share) into which each such share of Preferred Stock held by such holder
could be converted on the date for determination of stockholders entitled to
vote at the meeting or an the date of any written consent.

                                     -14-
<PAGE>

     With respect to all questions as to which, under law, stockholders are
required to vote by classes, each of the Series A Preferred Stock and Series B
Preferred Stock shall vote separately as a single class apart from each other
and from the Common Stock.

     Section 5.  Dividends.
     ---------   ---------

          (a) The holders of Series B Preferred Stock shall be entitled to
receive, from funds legally available therefor, a noncumulative dividend at the
rate of $.05 per share per annum, payable when and as declared by the Board of
Directors.  No dividends shall be declared or paid to the holders of Series A
Preferred Stock or Common Stock unless the holders of Series B Preferred Stock
have been paid in full all of the dividends to which they are entitled, nor
shall any dividends be declared or paid to the holders of Series A Preferred
Stock or Common Stock at a rate greater than the rate paid to the holders of
Series B Preferred Stock.

          (b) Subject to Subsection 5(a), dividends may be declared and paid on
Series A Preferred Stock from funds lawfully available therefor as and when
determined by the Board of Directors of the Corporation.  If, when and as
dividends are declared and paid on shares of Series A Preferred Stock, the
Corporation shall, after making payment in full to the holders of Series B
Preferred Stock the amounts to which they are entitled pursuant to Subsection
5(a), declare and pay at the same time to each holder of Series B Preferred
Stock, a dividend at the same rate, based on the number of shares of Common
Stock into which the Series B Preferred Stock and the Series A Preferred Stock
are convertible on the record date for the determination of holders of Series A
Preferred Stock entitled to receive such dividend.

          (c) Subject to Subsection 5(a), dividends may be declared and paid an
Common Stock from funds lawfully available therefor as and when determined by
the Board of Directors of the Corporation.  If, when and as dividends are
declared and paid on shares of Common Stock, the Corporation shall, after making
payment in full to the holders of Series B Preferred Stock the amounts to which
they are entitled pursuant to Subsection 5(a), declare and pay at the same time
to each holder of Preferred Stock, a dividend equal to the dividend which would
have been payable to such holder if the shares of Preferred Stock held by such
holder had been converted into Common Stock on the record date for the
determination of holders of Common Stock entitled to receive such dividend.

     Section 6.  Redemption.
     ---------   ----------

          (a) In the event that the Corporation shall exercise its put option to
sell shares of capital stock of Sequenom Instruments GmbH to Technologie-
Beteiligungs-Gesellschaft mbH der Deutschen Auesgleichsbank ("TBG") pursuant to
that certain Kooperationsvertrag between the Corporation and TBG relating to the
investment by the Corporation of DM 3 million in Sequenom Instruments GmbH, the
Corporation shall, within 30 days after receipt of the proceeds of the sale of
such shares to the TBG, send notice of such exercise (the "Put Exercise Notice")
by first class mail, postage prepaid, to each holder of record of the Series B
Preferred Stock at its address as it appears on the books of the Corporation,
specifying (i) the amount of proceeds so received from the TBG net of any
expenses incurred in connection therewith (the "Put Net Proceeds"), (ii) the
date (the "Redemption Date") on which the Corporation will redeem shares of
Series B Preferred Stock from electing holders of the Series B Preferred Stock
in accordance

                                     -15-
<PAGE>

with this Section 6, which Redemption Date shall be not less than 45 days nor
more than 90 days after the date of such notice (the "Notice Date") and (iii)
each such holder's Pro Rata Redemption Amount (as hereinafter defined).

          (b) Each holder of Series B Preferred Stock may elect to have the
Corporation redeem from it on the Redemption Date, to the extent the Corporation
has funds legally available for such purpose, up to a number of shares of Series
B Preferred Stock equal to such holder's Pro Rata Redemption Amount (as
hereinafter defined) at a redemption price of $1.50 per share.  Such election
may be made only by delivering to the Corporation within thirty (30) days after
the Notice Date (i) a written election signed by such holder specifying the
number of shares of Series B Preferred Stock so to be redeemed (which number
shall be not more than such holder's Pro Rata Redemption Amount), and (ii)
certificates for the shares of Series B Preferred Stock so to be redeemed,
together with stock powers therefor duly executed by such holder in blank.

          (c) For purposes of this Section 6, each holder of Series B Preferred
Stock's "Pro Rata Redemption Amount" shall be the greatest whole number
represented by a fraction, the numerator or which is the product of the number
of shares of Series B Preferred Stock held by such holder times the Put Net
Proceeds, and the denominator or which is the product of the total number of
shares of Series B Preferred Stock issued and outstanding times $1.50.

          (d) On the Redemption Date the Corporation shall redeem from the
electing holders of Series B Preferred Stock the shares of Series B Preferred
Stock as to which election notices have been properly given, to the extent the
Corporation has funds legally available for such purpose.

          (e) If the funds of the Corporation legally available for redemption
of shares of Series B Preferred Stock on the Redemption Date are insufficient to
redeem the total number of shares of Series B Preferred Stock submitted for
redemption, those funds which are legally available will be used to redeem the
maximum possible number of whole shares ratably among the holders of such shares
in accordance with the manner of determining the "Pro Rata Redemption Amount"
set forth above.  The shares of Series B Preferred Stock not redeemed shall
remain outstanding and entitled to all rights and preferences provided herein.

     Section 7.  Residual Rights.  All rights accruing to the outstanding shares
     ---------   ---------------
of the Corporation not expressly provided for to the contrary herein shall be
vested in the Common Stock.

                                     -16-
<PAGE>

                           CERTIFICATE OF AMENDMENT
                                      OF
                         CERTIFICATE OF INCORPORATION
                               OF SEQUENOM, INC.

     Sequenom, Inc., a corporation organized and existing under and by virtue of
the General Corporation Law of the State of Delaware, DOES HEREBY CERTIFY:

     FIRST:     That at a meeting of the Board of Directors of said corporation
                resolutions were duly adopted proposing and declaring advisable
                that the Certificate of Incorporation of said corporation be
                amended and that such amendment be submitted to the stockholders
                of the Corporation for their consideration, as follows;

     RESOLVED:  That the Board of Directors of this Corporation recommends and
                deems it advisable that the Certificate of Incorporation of this
                Corporation, as heretofore amended, be further amended by
                replacing the number "10,753,366" in the first paragraph of
                Article FOURTH thereof with the number "10,396,696," by
                replacing the number "3,376,666" in such first paragraph of
                Article FOURTH thereof with the number "3,019,996," and by
                replacing the number "$10,753.37" in such first paragraph of
                Article FOURTH thereof with the number "$10,396.696," so that
                such first paragraph reads as follows:

                         "The total number of shares of all classes of stock
                         which the Corporation has authority to issue is
                         10,396,696 shares, consisting of 5,726,700 shares of
                         Common Stock, par value $.001 per share (the "Common
                         Stock"), 1,650,000 shares of Series A Convertible
                         Preferred Stock, par value $.00l per share (the "Series
                         A Preferred Stock"), and 3,019,996 shares of Series B
                         Convertible Preferred Stock, par value $.001 per share
                         (the "Series B Preferred Stock", and, together with the
                         Series A Preferred Stock, the "Preferred Stock"),
                         amounting to an aggregate par value of $10,396.696."

     RESOLVED:  That the Board of Directors of this Corporation recommends and
                deems it advisable that the Certificate of Incorporation of this
                Corporation, as heretofore amended, be further amended by
                replacing the number "700,000" in Section 2(e)(i)(4)(C) of
                Article FOURTH thereof with the number "1,000,000" so that such
                section reads an follows

                         (C) up to 1,000,000 shares of Common Stock issued or
                         issuable to officers or employees or directors of, or
                         consultants to, the Corporation pursuant to a stock
                         purchase or option plan or other employee stock bonus
                         arrangement

<PAGE>

                         (collectively, the "Plans") approved by the Board of
                         Directors;"

     RESOLVED:  That the aforesaid proposed amendments be submitted to the
                stockholders of the Corporation for their consideration; and

     RESOLVED:  That following the approval by the stockholders of the aforesaid
                amendments as required by law, the officers of this Corporation
                be, and they hereby are, and each of them hereby is, authorized
                and directed (i) to prepare, execute and file with the Secretary
                of State of the State of Delaware a Certificate of Amendment
                setting forth the aforesaid amendments in the form approved by
                the stockholders and (ii) to take any and all other actions
                necessary, desirable or convenient to give effect to the
                aforesaid amendments or otherwise to carry out the purposes of
                the foregoing Resolutions.

     SECOND:    That in lieu of a meeting and vote of stockholders, the
                stockholders have given written consent to said amendments in
                accordance with the provisions of section 228 of the General
                Corporation Law of the State of Delaware, and written notice of
                the adoption of the amendments has been given as provided in
                section 228 of the General Corporation Law of the State of
                Delaware to every stockholder entitled to such notice.

     THIRD:     That the aforesaid amendments were duly adopted in accordance
                with the applicable provisions of sections 228 and 242 of the
                General Corporation Law of the State of Delaware.

     IN WITNESS WHEREOF, said Sequenom, Inc. has caused this certificate to be
signed by Fareed Kureshy, its President, and attested by John J. DiBello, its
Assistant Secretary, this 18th day of November, 1996.



ATTEST:                                          SEQUENOM, INC.




By:  /s/ illegible                               By:  /s/ illegible
   ---------------------------                      ---------------------------
   Assistant Secretary                              President

                                      -2-
<PAGE>

                                    By-Laws
                                      of
                                Sequenom, Inc.
<PAGE>

                                                                       Exhibit A
                                                                       ---------
                                    BY-LAWS
                                      OF
                                SEQUENOM, INC.

     Section 1.  CERTIFICATE OF INCORPORATION AND BY-LAWS

     1.1  These by-laws are subject to the certificate of incorporation of the
corporation.  In these by-laws, references to the certificate of incorporation
and by-laws mean the provisions of the certificate of incorporation and the by-
laws as are from time to time in effect.

     Section 2.  OFFICES

     2.1  Registered Office.  The registered office shall be in the City  of
          -----------------
Wilmington, County of New Castle, State of Delaware.

     2.2  Other Offices.  The corporation may also have offices at such other
          -------------
places both within and without the State of Delaware as the board of directors
may from time to time determine or the business of the corporation may require.

     Section 3.  STOCKHOLDERS

     3.1  Location of Meetings.  All meetings of the stockholders shall be held
          --------------------
at such place either within or without the State of Delaware as shall be
designated from time to time by the board of directors.  Any adjourned session
of any meeting shall be held at the place designated in the vote of adjournment.

     3.2  Annual Meeting.  The annual meeting of stockholders shall be held at
          --------------
10:00 a.m. on the second Wednesday in May in each year, unless that day be a
legal holiday at the place where the meeting is to be held, in which case the
meeting shall be held at the same hour on the next succeeding day not a legal
holiday, or at such other date and time as shall be designated from time to time
by the board of directors, at which they shall elect a board of directors and
transact such other business as may be required by law or these by-laws or as
may properly come before the meeting.

     3.3  Special Meeting in Place of Annual Meeting.  If the election for
          ------------------------------------------
directors shall not be held on the day designated by these by-laws, the
directors shall cause the election to be held as soon thereafter as convenient,
and to that end, if the annual meeting is omitted on the day herein provided
therefor or if the election of directors shall not be held thereat, a special
meeting of the stockholders may be held in place of such omitted meeting or
election, and any business transacted or election held at such special meeting
shall have the same effect as if transacted or held at the annual meeting, and
in such case all references in these by-laws to the annual meeting of the
stockholders, or to the annual election of directors, shall be deemed to refer
to or include such special meeting.  Any such special meeting shall be called
and the purposes thereof shall be specified in the call, as provided in Section
3.4.
<PAGE>

     3.4  Notice of Annual Meeting.  Written notice of the annual meeting
          ------------------------
stating the place, date and hour of the meeting shall be given to each
stockholder entitled to vote at such meeting not less than ten nor more than
sixty days before the date of the meeting.  Such notice may specify the business
to be transacted and actions to be taken at such meeting.  No action shall be
taken at such meeting unless such notice is given, or unless waiver of such
notice is given by the holders of outstanding stock having not less than the
minimum number of votes necessary to take such action at a meeting at which all
shares entitled to vote thereon were voted.  Prompt notice of all action taken
in connection with such waiver of notice shall be given to all stockholders not
present or represented at such meeting.

     3.5  Other Special Meetings.  Special meetings of the stockholders, for any
          ----------------------
purpose or purposes, unless otherwise prescribed by law or by the certificate of
incorporation, may be called by the president and shall be called by the
president or secretary at the request in writing of a majority of the board of
directors, or at the request in writing of the holders of at least ten percent
of all capital stock of the corporation issued and outstanding and entitled to
vote at such meeting.  Such request shall state the purpose or purposes of the
proposed meeting and business to be transacted at any special meeting of the
stockholders.

     3.6  Notice of Special Meeting.  Written notice of a special meeting
          -------------------------
stating the place, date and hour of the meeting and the purpose or purposes for
which the meeting is called, shall be given not less than ten nor more than
sixty days before the date of the meeting, to each stockholder entitled to vote
at such meeting.  No action shall be taken at such meeting unless such notice is
given, or unless waiver of such notice is given by the holders of outstanding
stock having not less than the minimum number of votes necessary to take such
action at a meeting at which all shares entitled to vote thereon were voted.
Prompt notice of all action taken in connection with such waiver of notice shall
be given to all stockholders not present or represented at such meeting.

     3.7  Stockholder List.  The officer who has charge of the stock ledger of
          ----------------
the corporation shall prepare and make, at least ten days before every meeting
of stockholders, a complete list of the stockholders entitled to vote at the
meeting, arranged in alphabetical order, and showing the address of each
stockholder and the number of shares registered in the name of each stockholder.
Such list shall be open to the examination of any stockholder, for any purpose
germane to the meeting, during ordinary business hours, for a period of at least
ten days prior to the meeting, either at a place within the city where the
meeting is to be held, which place shall be specified in the notice of the
meeting, or, if not so specified, at the place where the meeting is to be held.
The list shall also be produced and kept at the time and place of the meeting
during the whole time thereof, and may be inspected by any stockholder who is
present.

     3.8  Quorum of Stockholders.  The holders of a majority of the stock issued
          ----------------------
and outstanding and entitled to vote thereat, present in person or represented
by proxy, shall constitute a quorum at all meetings of the stockholders for the
transaction of business except as otherwise required by law, or by the
certificate of incorporation or by these by-laws.  Except as otherwise provided
by law, no stockholder present at a meeting may withhold his shares from the
quorum count by declaring his shares absent from the meeting.

                                      -1-
<PAGE>

     3.9  Adjournment.  Any meeting of stockholders may be adjourned from time
          -----------
to time to any other time and to any other place at which a meeting of
stockholders may be held under these by-laws, which time and place shall be
announced at the meeting, by a majority of votes cast upon the question, whether
or not a quorum is present.  At such adjourned meeting at which a quorum shall
be present or represented any business may be transacted which might have been
transacted at the original meeting.  If the adjournment is for more than thirty
days, or if after the adjournment a new record date is fixed for the adjourned
meeting, a notice of the adjourned meeting shall be given to each stockholder of
record entitled to vote at the meeting.

     3.10  Proxy Representation.  Every stockholder may authorize another person
           --------------------
or persons to act for him by proxy in all matters in which a stockholder is
entitled to participate, whether by waiving notice of any meeting, objecting to
or voting or participating at a meeting, or expressing consent or dissent
without a meeting.  Every proxy must be signed by the stockholder or by his
attorney-in-fact.  No proxy shall be voted or acted upon after three years from
its date unless such proxy provides for a longer period.  Except as provided by
law, a revocable proxy shall be deemed revoked if the stockholder is present at
the meeting for which the proxy was given.  A duly executed proxy shall be
irrevocable if it states that it is irrevocable and, if, and only as long as, it
is coupled with an interest sufficient in law to support an irrevocable power.
A proxy may be made irrevocable regardless of whether the interest with which it
is coupled is an interest in the stock itself or an interest in the corporation
generally.  The authorization of a proxy may but need not be limited to
specified action, provided, however, that if a proxy limits its authorization to
a meeting or meetings of stockholders, unless otherwise specifically provided
such proxy shall entitle the holder thereof to vote at any adjourned session but
shall not be valid after the final adjournment thereof.

     3.11  Inspectors.  The directors or the person presiding at the meeting
           ----------
may, but need not, appoint one or more inspectors of election and any substitute
inspectors to act at the meeting or any adjournment thereof.  Each inspector,
before entering upon the discharge of his duties, shall take and sign an oath
faithfully to execute the duties of inspector at such meeting with strict
impartiality and according to the best of his ability.  The inspectors, if any,
shall determine the number of shares of stock outstanding and the voting power
of each, the shares of stock represented at the meeting, the existence of a
quorum and the validity and effect of proxies, and shall receive votes, ballots
or consents, hear and determine all challenges and questions arising in
connection with the right to vote, count and tabulate all votes, ballots or
consents, determine the result, and do such acts as are proper to conduct the
election or vote with fairness to all stockholders.  On request of the person
presiding at the meeting, the inspectors shall make a report in writing of any
challenge, question or matter determined by them and execute a certificate of
any fact found by them.

     3.12  Action by Vote.  When a quorum is present at any meeting, whether the
           --------------
same be an original or an adjourned session, a plurality of the votes properly
cast for election to any office shall elect to such office and a majority of the
votes properly cast upon any question other than an election to an office shall
decide the question, except when a larger vote is required by law, by the
certificate of incorporation or by these by-laws.  No ballot shall be required
for any election unless requested by a stockholder present or represented at the
meeting and entitled to vote in the election.

                                      -2-
<PAGE>

     3.13  Action Without Meetings.  Unless otherwise provided in the
           -----------------------
certificate of incorporation, any action required to be taken at any annual or
special meeting of stockholders of the corporation, or any action which may be
taken at any annual or special meeting of such stockholders, may be taken
without a meeting, without prior notice and without a vote, if a consent in
writing, setting forth the action so taken shall be signed by the holders of
outstanding stock having not less than the minimum number of votes that would be
necessary to authorize or take such action at a meeting at which all shares
entitled to vote thereon were present and voted.  Prompt notice of the taking of
the corporate action without a meeting by less than unanimous written consent
shall be given to those stockholders who have not consented in writing.

     Section 4.  DIRECTORS

     4.1  Number.  The number of directors which shall constitute the whole
          ------
board shall not be less than three nor more than seven, except that whenever
there shall be only one stockholder or prior to issuance of any stock, the
number of directors which shall constitute the whole board shall be not less
than one.  Within the foregoing limits, the stockholders at the annual meeting
shall determine the number of directors, and within such limits, the number of
directors may be increased or decreased at any time or from time to time by the
stockholders or by the directors by vote of a majority of directors then in
office, except that any such decrease by vote of the directors shall only be
made to eliminate vacancies existing by reason of the death, resignation or
removal of one or more directors.  The directors shall be elected at the annual
meeting of the stockholders, except as provided in Section 4.4 of these by-laws.
Directors need not be stockholders.

     4.2  Tenure.  Except as otherwise provided by law, by the certificate of
          ------
incorporation or by these by-laws, each director shall hold office until the
next annual meeting and until his successor is elected and qualified, or until
he sooner dies, resigns, is removed or becomes disqualified.

     4.3  Powers.  The business of the corporation shall be managed by or under
          ------
the direction of the board of directors which shall have and may exercise all
the powers of the corporation and do all such lawful acts and things as are not
by law, the certificate of incorporation or these by-laws directed or required
to be exercised or done by the stockholders.

     4.4  Vacancies.  Vacancies and any newly created directorships resulting
          ---------
from any increase in the number of directors may be filled by vote of the
stockholders at a meeting called for the purpose, or by a majority of the
directors then in office, although less than a quorum, or by a sole remaining
director.  When one or more directors shall resign from the board, effective at
a future date, a majority of the directors then in office, including those who
have resigned, shall have power to fill such vacancy or vacancies, the vote or
action by writing thereon to take effect when such resignation or resignations
shall become effective.  The directors shall have and may exercise all their
powers notwithstanding the existence of one or more vacancies in their number,
subject to any requirements of law or of the certificate of incorporation or of
these by-laws as to the number of directors required for a quorum or for any
vote or other actions.

     4.5  Committees.  The board of directors may, by vote of a majority of the
          ----------
whole board, (a) designate, change the membership of or terminate the existence
of any committee or

                                      -3-
<PAGE>

committees, each committee to consist of one or more of the directors; (b)
designate one or more directors as alternate members of any such committee who
may replace any absent or disqualified member at any meeting of the committee;
and (c) determine the extent to which each such committee shall have and may
exercise the powers and authority of the board of directors in the management of
the business and affairs of the corporation, including the power to authorize
the seal of the corporation to be affixed to all papers which require it and the
power and authority to declare dividends or to authorize the issuance of stock;
excepting, however, such powers which by law, by the certificate of
incorporation or by these by-laws they are prohibited from so delegating. In the
absence or disqualification of any member of such committee and his alternate,
if any, the member or members thereof present at any meeting and not
disqualified from voting, whether or not constituting a quorum, may unanimously
appoint another member of the board of directors to act at the meeting in the
place of any such absent or disqualified member. Except as the board of
directors may otherwise determine, any committee may make rules for the conduct
of its business, but unless otherwise provided by the board or such rules, its
business shall be conducted as nearly as may be in the same manner as is
provided by these by-laws for the conduct of business by the board of directors.
Each committee shall keep regular minutes of its meetings and report the same to
the board of directors upon request.

     4.6  Regular Meeting.  Regular meetings of the board of directors may be
          ---------------
held without call or notice at such place within or without the State of
Delaware and at such times as the board may from time to time determine,
provided that notice of the first regular meeting following any such
determination shall be given to absent directors.  A regular meeting of the
directors may be held without call or notice immediately after and at the same
place as the annual meeting of the stockholders.

     4.7  Special Meetings.  Special meetings of the board of directors may be
          ----------------
held at any time and at any place within or without the State of Delaware
designated in the notice of the meeting, when called by the president, or by
one-third or more in number of the directors, reasonable notice thereof being
given to each director by the secretary or by the president or by any one of the
directors calling the meeting.

     4.8  Notice.  It shall be reasonable and sufficient notice to a director to
          ------
send notice by mail at least forty-eight hours or by telegram at least twenty-
four hours before the meeting, addressed to him at his usual or last known
business or residence address or to give notice to him in person or by telephone
at least twenty-four hours before the meeting.  Notice of a meeting need not be
given to any director if a written waiver of notice, executed by him before or
after the meeting, is filed with the records of the meeting, or to any director
who attends the meeting without protesting prior thereto or at its commencement
the lack of notice to him.  Neither notice of a meeting nor a waiver of a notice
need specify the purposes of the meeting.

     4.9  Quorum.  Except as may be otherwise provided by law, by the
          ------
certificate of incorporation or by these by-laws, at any meeting of the
directors a majority of the directors then in office shall constitute a quorum;
a quorum shall not in any case be less than one-third of the total number of
directors constituting the whole board.  Any meeting may be adjourned from time
to time by a majority of the votes cast upon the question, whether or not a
quorum is present, and the meeting may be held as adjourned without further
notice.

                                      -4-
<PAGE>

     4.10  Action by Vote.  Except as may be otherwise provided by law, by the
           --------------
certificate of incorporation or by these by-laws, when a quorum is present at
any meeting the vote of a majority of the directors present shall be the act of
the board of directors.

     4.11  Action Without a Meeting.  Unless otherwise restricted by the
           ------------------------
certificate of incorporation or these by-laws, any action required or permitted
to be taken at any meeting of the board of directors or of any committee thereof
may be taken without a meeting if all the members of the board or of such
committee, as the case may be, consent thereto in writing, and such writing or
writings are filed with the records of the meetings of the board or of such
committee.  Such consent shall be treated for all purposes as the act of the
board or of such committee, as the case may be.

     4.12  Participation in Meetings by Conference Telephone.  Unless otherwise
           -------------------------------------------------
restricted by the certificate of incorporation or these by-laws, members of the
board of directors or of any committee thereof may participate in a meeting of
such board or committee by means of conference telephone or similar
communications equipment by means of which all persons participating in the
meeting can hear each other.  Such participation shall constitute presence in
person at such meeting.

     4.13  Compensation.  Unless otherwise restricted by the certificate of
           ------------
incorporation or these by-laws, the board of directors shall have the authority
to fix from time to time the compensation of directors.  The directors may be
paid their expenses, if any, of attendance at each meeting of the board of
directors and the performance of their responsibilities as directors and may be
paid a fixed sum for attendance at each meeting of the board of directors and/or
a stated salary as director.  No such payment shall preclude any director from
serving the corporation or its parent or subsidiary corporations in any other
capacity and receiving compensation therefor.  The board of directors may also
allow compensation for members of special or standing committees for service on
such committees.

     4.14  Interested Directors and Officers.
           ---------------------------------

          (a) No contract or transaction between the corporation and one or more
of its directors or officers, or between the corporation and any other
corporation, partnership, association, or other organization in which one or
more of the corporations, directors or officers are directors or officers, or
have a financial interest, shall be void or voidable solely for this reason, or
solely because the director or officer is present at or participates in the
meeting of the board or committee thereof which authorizes the contract or
transaction, or solely because his or their votes are counted for such purpose,
if:

          (1) The material facts as to his relationship or interest and as to
the contract or transaction are disclosed or are known to the board of directors
or the committee, and the board or committee in good faith authorizes the
contract or transaction by the affirmative votes of a majority of the
disinterested directors, even though the disinterested directors be less than a
quorum; or

                                      -5-
<PAGE>

          (2) The material facts as to his relationship or interest and as to
the contract or transaction are disclosed or are known to the stockholders
entitled to vote thereon, and the contract or transaction is specifically
approved in good faith by vote of the stockholders; or

          (3) The contract or transaction is fair as to the corporation as of
the time it is authorized, approved or ratified, by the board of directors, a
committee thereof, or the stockholders.

          (b) Common or interested directors may be counted in determining the
presence of a quorum at a meeting of the board of directors or of a committee
which authorizes the contract or transaction.

     4.15  Resignation or Removal of Directors.  Unless otherwise restricted by
           -----------------------------------
the certificate of incorporation or by law, any director or the entire board of
directors may be removed, with or without cause, by the holders of a majority of
the stock issued and outstanding and entitled to vote at an election of
directors.  Any director may resign at any time by delivering his resignation in
writing to the president or the secretary or to a meeting of the board of
directors.  Such resignation shall be effective upon receipt unless specified to
be effective at some other time; and without in either case the necessity of its
being accepted unless the resignation shall so state.  No director resigning and
(except where a right to receive compensation shall be expressly provided in a
duly authorized written agreement with the corporation) no director removed
shall have any right to receive compensation as such director for any period
following his resignation or removal, or any right to damages on account of such
removal, whether his compensation be by the month or by the year or otherwise;
unless in the case of a resignation, the directors, or in the case of removal,
the body acting on the removal, shall in their or its discretion provide for
compensation.

     Section 5.  NOTICES

     5.1  Form of Notice.  Whenever, under the provisions of law, or of the
          --------------
certificate of incorporation or of these by-laws, notice is required to be given
to any director or stockholder, such notice may be given by mail, addressed to
such director or stockholder, at his address as it appears on the records of the
corporation, with postage thereon prepaid, and such notice shall be deemed to be
given at the time when the same shall be deposited in the United States mail.
Unless written notice by mail is required by law, written notice may also be
given by telegram, cable, telecopy, commercial delivery service, telex or
similar means, addressed to such director or stockholder at his address as it
appears on the records of the corporation, in which case such notice shall be
deemed to be given when delivered into the control of the persons charged with
effecting such transmission, the transmission charge to be paid by the
corporation or the person sending such notice and not by the addressee.  Oral
notice or other in-hand delivery (in person or by telephone) shall be deemed
given at the time it is actually given.

     5.2  Waiver of Notice.  Whenever notice is required to be given under the
          ----------------
provisions of law, the certificate of incorporation or these by-laws, a written
waiver thereof, signed by the person entitled to notice, whether before or after
the time stated therein, shall be deemed equivalent to notice.  Attendance of a
person at a meeting shall constitute a waiver of notice of such meeting, except
when the person attends a meeting for the express purpose of objecting, at

                                      -6-
<PAGE>

the beginning of the meeting, to the transaction of any business because the
meeting is not lawfully called or convened. Neither the business to be
transacted at, nor the purpose of, any meeting of the stockholders, directors or
members of a committee of the directors need be specified in any written waiver
of notice.

     Section 6.  OFFICERS AND AGENTS

     6.1  Enumeration; Qualification.  The officers of the corporation shall be
          --------------------------
a president, a treasurer, a secretary and such other officers, if any, as the
board of directors from time to time may in its discretion elect or appoint
including without limitation one or more vice presidents.  Any officer may be,
but none need be, a director or stockholder.  Any two or more offices may be
held by the same person.  Any officer may be required by the board of directors
to secure the faithful performance of his duties to the corporation by giving
bond in such amount and with sureties or otherwise as the board of directors may
determine.

     6.2  Powers.  Subject to law, to the certificate of incorporation and to
          ------
the other provisions of these by-laws, each officer shall have, in addition to
the duties and powers herein set forth, such duties and powers as are commonly
incident to his office and such additional duties and powers as the board of
directors may from time to time designate.

     6.3  Election.  The board of directors at its first meeting after each
          --------
annual meeting of stockholders shall choose a president, a secretary and a
treasurer.  Other officers may be appointed by the board of directors at such
meeting, at any other meeting or by written consent.  At any time or from time
to time, the directors may delegate to any officer their power to elect or
appoint any other officer or any agents.

     6.4  Tenure.  Each officer shall hold office until the first meeting of the
          ------
board of directors following the next annual meeting of the stockholders and
until his successor is elected and qualified unless a shorter period shall have
been specified in terms of his election or appointment, or in each case until he
sooner dies, resigns, is removed or becomes disqualified.  Each agent of the
corporation shall retain his authority at the pleasure of the directors, or the
officer by whom he was appointed or by the officer who then holds agent
appointive power.

     6.5  President and Vice Presidents.  The president shall be the chief
          -----------------------------
executive officer and shall have direct and active charge of all business
operations of the corporation and shall have general supervision of the entire
business of the corporation, subject to the control of the board of directors.
He shall preside at all meetings of the stockholders and of the board of
directors at which he is present, except as otherwise voted by the board of
directors.

     The president or treasurer shall execute bonds, mortgages and other
contracts requiring a seal, under the seal of the corporation, except where
required or permitted by law to be otherwise signed and executed and except
where the signing and execution thereof shall be expressly delegated by the
board of directors to some other officer or agent of the corporation.

     Any vice presidents shall have such duties and powers as shall be
designated from time to time by the board of directors or by the president.

                                      -7-
<PAGE>

     6.6  Treasurer and Assistant Treasurers.  The treasurer shall be the chief
          ----------------------------------
financial officer of the corporation and shall be in charge of its funds and
valuable papers, and shall have such other duties and powers as may be assigned
to him from time to time by the board of directors or by the president.

     Any assistant treasurers shall have such duties and powers as shall be
designated from time to time by the board of directors, the president or the
treasurer.

     6.7  Secretary and Assistant Secretaries.  The secretary shall record all
          -----------------------------------
proceedings of the stockholders, of the board of directors and of committees of
the board of directors in a book or series of books to be kept therefor and
shall file therein all writings of, or related to, action by stockholder or
director consent.  In the absence of the secretary from any meeting, an
assistant secretary, or if there is none or he is absent, a temporary secretary
chosen at the meeting, shall record the proceedings thereof.  Unless a transfer
agent has been appointed, the secretary shall keep or cause to be kept the stock
and transfer records of the corporation, which shall contain the names and
record addresses of all stockholders and the number of shares registered in the
name of each stockholder.  The secretary shall have such other duties and powers
as may from time to time be designated by the board of directors or the
president.

     Any assistant secretaries shall have such duties and powers as shall be
designated from time to time by the board of directors, the president or the
secretary.

     6.8  Resignation and Removal.  Any officer may resign at any time by
          -----------------------
delivering his resignation in writing to the president or the secretary or to a
meeting of the board of directors.  Such resignation shall be effective upon
receipt unless specified to be effective at some other time, and without in any
case the necessity of its being accepted unless the resignation shall so state.
The board of directors may at any time remove any officer either with or without
cause.  The board of directors may at any time terminate or modify the authority
of any agent.  No officer resigning and (except where a right to receive
compensation shall be expressly provided in a duly authorized written agreement
with the corporation) no officer removed shall have any right to any
compensation as such officer for any period following his resignation or
removal, or any right to damages on account of such removal, whether his
compensation be by the month or by the year or otherwise; unless in the case of
a resignation, the directors, or in the case of removal, the body acting on the
removal, shall in their or its discretion provide for compensation.

     6.9  Vacancies.  If the office of the president or the treasurer or the
          ---------
secretary becomes vacant, the directors may elect a successor by vote of a
majority of the directors then in office.  If the office of any other officer
becomes vacant, any person or body empowered to elect or appoint that office may
choose a successor.  Each such successor shall hold office for the unexpired
term of his predecessor, and in the case of the president, the treasurer and the
secretary until his successor is chosen and qualified, or in each case until he
sooner dies, resigns, is removed or becomes disqualified.

     Section 7.  CAPITAL STOCK

     7.1  Stock Certificates.  Each stockholder shall be entitled to a
          ------------------
certificate stating the number and the class and the designation of the series,
if any, of the shares held by him, in such

                                      -8-
<PAGE>

form as shall, in conformity to law, the certificate of incorporation and the
by-laws, be prescribed from time to time by the board of directors. Such
certificate shall be signed by the president or a vice-president and (i) the
treasurer or an assistant treasurer or (ii) the secretary or an assistant
secretary. Any of or all the signatures on the certificate may be a facsimile.
In case an officer, transfer agent or registrar who has signed or whose
facsimile signature has been placed on such certificate shall have ceased to be
such officer, transfer agent or registrar before such certificate is issued, it
may be issued by the corporation with the same effect as if he were such
officer, transfer agent, or registrar at the time of its issue.

     7.2  Lost Certificates.  The board of directors may direct a new
          -----------------
certificate or certificates to be issued in place of any certificate or
certificates theretofore issued by the corporation alleged to have been lost,
stolen or destroyed, upon the making of an affidavit of that fact by the person
claiming the certificate of stock to be lost, stolen or destroyed.  When
authorizing such issue of a new certificate or certificates, the board of
directors may, in its discretion and as a condition precedent to the issuance
thereof, require the owner of such lost, stolen or destroyed certificate or
certificates, or his legal representative, to advertise the same in such manner
as it shall require and/or to give the corporation a bond in such sum as it may
direct as indemnity against any claim that may be made against the corporation
with respect to the certificate alleged to have been lost, stolen or destroyed.

     Section 8.  TRANSFER OF SHARES OF STOCK

     8.1  Transfer on Books.  Subject to any restrictions with respect to the
          -----------------
transfer of shares of stock, shares of stock may be transferred on the books of
the corporation by the surrender to the corporation or its transfer agent of the
certificate therefor properly endorsed or accompanied by a written assignment
and power of attorney properly executed, with necessary transfer stamps affixed,
and with such proof of the authenticity of signature as the board of directors
or the transfer agent of the corporation may reasonably require.  Except as may
be otherwise required by law, by the certificate of incorporation or by these
by-laws, the corporation shall be entitled to treat the record holder of stock
as shown on its books as the owner of such stock for all purposes, including the
payment of dividends and the ,right to receive notice and to vote or to give any
consent with respect thereto and to be held liable for such calls and
assessments, if any, as may lawfully be made thereon, regardless of any
transfer, pledge or other disposition of such stock until the shares have been
properly transferred on the books of the corporation.

     It shall be the duty of each stockholder to notify the corporation of his
post office address.

     Section 9.  GENERAL PROVISIONS

     9.1  Record Date.  In order that the corporation may determine the
          -----------
stockholders entitled to notice of or to vote at any meeting of stockholders or
any adjournment thereof, or to express consent to corporate action in writing
without a meeting, or entitled to receive payment of any dividend or other
distribution or allotment of any rights, or entitled to exercise any rights in
respect of any change, conversion or exchange of stock or for the purpose of any
other lawful action, the board of directors may fix, in advance, a record date,
which shall not be more than

                                      -9-
<PAGE>

sixty days nor less than ten days before the date of such meeting, nor more than
sixty days prior to any other action to which such record date relates. A
determination of stockholders of record entitled to notice of or to vote at a
meeting of stockholders shall apply to any adjournment of the meeting; provided,
however, that the board of directors may fix a new record date for the adjourned
meeting. If no record date is fixed,

     (a) The record date for determining stockholders entitled to notice of or
to vote at a meeting of stockholders shall be at the close of business on the
day next preceding the day on which notice is given, or, if notice is waived, at
the close of business on the day next preceding the day on which the meeting is
held;

     (b) The record date for determining stockholders entitled to express
consent to corporate action in writing without a meeting, when no prior action
by the board of directors is necessary, shall be the day on which the first
written consent is expressed; and

     (c) The record date for determining stockholders for any other purpose
shall be at the close of business on the day on which the board of directors
adopts the resolution relating to such purpose.

     9.2  Dividends.  Dividends upon the capital stock of the corporation may be
          ---------
declared by the board of directors at any regular or special meeting or by
written consent, pursuant to law.  Dividends may be paid in cash, in property,
or in shares of the capital stock, subject to the provisions of the certificate
of incorporation.

     9.3  Payment of Dividends.  Before payment of any dividend, there may be
          --------------------
set aside out of any funds of the corporation available  for dividends such sum
or sums as the directors from time to time, in their absolute discretion, think
proper as a reserve or reserves to meet contingencies, or for equalizing
dividends, or for repairing or maintaining any property of the corporation, or
for such other purpose as the directors shall think conducive to the interest of
the corporation, and the directors may modify or abolish any such reserve in the
manner in which it was created.

     9.4  Checks.  All checks or demands for money and notes of the corporation
          ------
shall be signed by such officer or officers or such other person or persons as
the board of directors may from time to time designate.

     9.5  Fiscal Year.  The fiscal year of the corporation shall begin on the
          -----------
first of January in each year and shall end on the last day of December next
following, unless otherwise determined by the board of directors.

     9.6  Seal.  The board of directors may, by resolution, adopt a corporate
          ----
seal.  The corporate seal shall have inscribed thereon the name of the
corporation, the year of its organization and the word "Delaware."  The seal may
be used by causing it or a facsimile thereof to be impressed or affixed or
reproduced or otherwise.  The seal may be altered from time to time by the board
of directors.

                                     -10-
<PAGE>

     Section 10.  INDEMNIFICATION

     10.1  It being the intent of the corporation to provide maximum protection
available under the law to its officers and directors, the corporation shall
indemnify its officers and directors to the full extent the corporation is
permitted or required to do so by the General Corporation Law of Delaware.

     Section 11.  AMENDMENTS

     11.1  These by-laws may be altered, amended or repealed or new by-laws may
be adopted by the stockholders or by the board of directors when such power is
conferred upon the board of directors by the certificate of incorporation, at
any regular meeting of the stockholders or of the board of directors or at any
special meeting of the stockholders or of the board of directors.  If the power
to adopt, amend or repeal by-laws is conferred upon the board of directors by
the certificate of incorporation, it shall not divest or limit the power of the
stockholders to adopt, amend or repeal by-laws.

                                     -11-
<PAGE>

                                  EXHIBIT 4.2
                                  -----------


                                Capitalization
                                --------------


     Attached hereto is a stockholder list dated March 1, 1997.

     Also attached hereto is a list of outstanding stock options and warrants
dated March 18, 1997.

     Other than shares reserved for issuance upon conversion of the Series C
Preferred and the Warrants, the Corporation has reserved the number of shares of
its capital stock set forth below:

<TABLE>
<CAPTION>

     Common Stock:
     -------------
<S>                                                 <C>

           Exercise of Options:                     1,078,000
           Conversion of
            Series A Preferred:                     1,650,000
            Series B Preferred:                     2,976,333
                                                    ---------

             Total:                                 5,087,083

     Series A Preferred:
     ------------------

          Exercise of Comdisco Warrant:                70,000
</TABLE>
<PAGE>

                                SEQUENOM, INC.

                               Stockholder List

                                 March 1, 1997
AUTHORIZED:
<TABLE>
<CAPTION>
                                         Par Value              Authorized                  Issued
                                         ---------              ----------                  ------
<S>                      <C>                       <C>                       <C>
Common:                                    $.001                 5,726,700                   148,251
Series A Convertible                       $.001                 1,650,000                 1,580,000
 Preferred:
Series B Convertible                       $.001                 3,019,996                 2,976,663
 Preferred:
</TABLE>

                                 COMMON STOCK
                                 ------------
<TABLE>
<CAPTION>
       Shareholder                        Shares                 Cert. No.                 Issue Date
       -----------                        ------                 ---------                 ----------
<S>                          <C>                        <C>                          <C>
Hubert Koster                                   1                  C-10                      03-08-95
Hallerstrasse 74
20146 Hamburg
Germany

***                                        90,000                  C-11                      10-16-95

***                                        26,250                  C-12                      10-31-95

Randall R. Lunn                            10,000                  C-13                      12-01-95
c/o TVM Techno Venture
 Management
101 Arch Street
Suite 1950
Boston, MA 02110

Helmut Schuhsler                           10,000                  C-14                      12-01-95
c/o TVM Techno Venture
 Management
101 Arch Street
Suite 1950
Boston, MA 02110
</TABLE>

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

<TABLE>
<S>                                             <C>                <C>                  <C>
Patricia Dane                                   2,000              C-15                 12-01-95
c/o TVM Techno Venture
 Management
101 Arch Street
Suite 1950
Boston, MA 02110

Amy B. Crawford                                 2,000              C-16                 12-01-95
c/o TVM Techno Venture
 Management
101 Arch Street
Suite 1950
Boston, MA 02110

Monica Schlawinsky                              2,000              C-17                 12-01-95
c/o TVM Techno Venture
 Management
101 Arch Street
Suite 1950
Boston, MA 02110

John J. DiBello                                 6,000              C-18                 12-01-95
c/o TVM Techno Venture
 Management
101 Arch Street
Suite 1950
Boston, MA 02110

        TOTAL:                                148,251
</TABLE>

<PAGE>

                     SERIES A CONVERTIBLE PREFERRED STOCK
                     ------------------------------------

<TABLE>
<CAPTION>
        Shareholder                          Shares                          Cert. No.               Issue Date
<S>                                         <C>                              <C>                     <C>
Hubert Koster                               1,120,000                            1                     03-08-95
Hallerstrasse 74
20146 Hamburg
Germany

***                                            40,000                            2                     03-08-95


***                                            20,000                            3                     03-08-95

TVM Techno Venture                              8,000                           10                     08-18-95
  Investors No. 1 Limited
  Partnership
101 Arch Street
Suite 1950
Boston, MA 02110

TVM Techno Venture                             63,680                           12                     08-18-95
  Enterprises No. II
  Limited Partnership
101 Arch Street
Suite 1950
Boston, MA 02110

TVM Intertech Limited                          42,454                           13                     08-18-95
  Partnership
101 Arch Street
Suite 1950
Boston, MA 02110

TVM Zweite Beteiligung -                       98,000                            6                     03-08-95
  U.S. Limited Partnership                     29,360                           11                     08-18-95
101 Arch Street
Suite 1950
Boston, MA 02110

TVM Eurotech Limited                           65,200                            7                     03-08-95
  Partnership                                  19,706                            9                     08-18-95
101 Arch Street
Suite 1950
Boston, MA 02110

***                                            73,600                            8                     03-08-95

        TOTAL:                              1,580,000
</TABLE>

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                     SERIES B CONVERTIBLE PREFERRED STOCK
                     ------------------------------------

<TABLE>
<CAPTION>
       Shareholder                            Shares             Cert. No.           Issue Date
       -----------                            ------             ---------           ----------
<S>                          <C>                        <C>                          <C>
TVM TechnoVenture                             212,267              B-1               12-22-95
  Enterprises No. II
  Limited Partnership
101 Arch Street
Suite 1950
Boston, MA 02110

TVM Intertech Limited                         141,513              B-2               12-22-95
  Partnership
101 Arch Street
Suite 1950
Boston, MA 02110

TVM Zweite Beteiligung-                       432,953              B-3               12-22-95
  U.S. Limited Partnership
101 Arch Street
Suite 1950
Boston, MA 02110

TVM Eurotech Limited                          288,633              B-4               12-22-95
  Partnership
101 Arch Street
Suite 1950
Boston, MA 02110

TVM Techno Venture                             12,634              B-5               12-22-95
  Investors No. 1 Limited                       6,666              B-13               2-29-96
  Partnership
101 Arch Street
Suite 1950
Boston, MA 02110

***                                           245,333              B-6               12-22-95

Alpinvest                                     666,667              B-7               12-22-95
International B.V.
Gooimeer 3
NL-1410 AB Naarden
The Netherlands

***                                           333,333              B-8               12-22-95

***                                            13,333              B-9                2-29-96
</TABLE>

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

<TABLE>
<S>                                             <C>                <C>                 <C>
***                                             6,666              B-10                2-29-96

***                                            66,666              B-11                2-29-96

***                                            20,000              B-12                2-29-96

***                                            33,333              B-14                2-29-96

***                                            33,333             B-15.                2-29-96

Hubert Koster                                 100,000              B-16                2-29-96
Hallerstrasse  74
20146 Hamburg
Germany

Ernst-Gunter Afting                            30,000              B-17                3-29-96
Maisenweg 21
82152 Krailing
Germany

***                                           218,768              B-18                3-29-96

***                                            18,294              B-19                3-29-96

</TABLE>

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

<TABLE>

<S>                              <C>                    <C>                    <C>
***                              96,271                 B-20                   3-29-96

          TOTAL:              2,976,663
</TABLE>

<PAGE>

                                  EXHIBIT 4.2

Sequenom, Inc.
Analysis of stock options and warrants outstanding
As of March 18, 1997

<TABLE>
<CAPTION>

                                                                             Shares under        Exercise price
Stock options:                                                              option/warrant         per share
- --------------                                                             ----------------     ----------------
Issued prior to 1996
- --------------------
<S>                                                                        <C>                  <C>
Hubert Koster (founder)                                                         80,000                0.05
***                                                                             30,000                0.05
***                                                                             42,000                0.05
Charles Cantor (technical advisory board)                                       66,000                0.05
***                                                                             10,000                0.05
***                                                                             10,000                0.05
***                                                                             10,000                0.05
Issued in 1996
- --------------
***                                                                              1,000                0.25
***                                                                              1,000                0.25
***                                                                              1,000                0.25
Dr. Andreas Braun (employee-l/96)                                               15,000                0.25
***                                                                             10,000                0.25
***                                                                             10,000                0.25
***                                                                              2,000                0.25
***                                                                              2,000                0.25
***                                                                              2,000                0.25
/*/**                                                                            3,000                0.25
Professor Ernst -Gnter Afting (bd member-1/96)                                  20,000                0.25
***                                                                              1,000                0.25
***                                                                              1,000                0.25
***                                                                              1,000                0.25
***                                                                            163,000                0.25
***                                                                            109,000                0.25
***                                                                              5,000                0.25
***                                                                              5,000                0.25
***                                                                              5,000                0.25
John J. DiBello (acting CFO- 9/96)                                               6,000                0.25
Tom Bologna (board member-12/96) -fully vested                                  18,000                0.25
Tom Bologna (board member-12/96) -stock only                                    27,000                0.25
Tom Bologna (board member- 12/96) -cash option                                  27,000                0.25
Total stock options outstanding                                                683,000
Stock warrants*:
- ---------------
***                                                                             70,000                0.25

Total options and warrants outstanding                                         753,000
                                                                           ===============
</TABLE>
*The stock warrants are for Series A preferred stock.

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                  EXHIBIT 4.3
                                  -----------


                               Equity Investments
                               ------------------

     The Corporation has one subsidiary, Sequenom Instruments GmbH, all of the
outstanding equity interest in which is owned by the Corporation.
<PAGE>

                                  EXHIBIT 4.4
                                  -----------


                        Unaudited Financial Statements
                          as of December 31, 1996 and
                            for the year then ended
                        ------------------------------
<PAGE>

DRAFT                            SEQUENOM, INC.

                       (A Development Stage Enterprise)

                          CONSOLIDATED BALANCE SHEETS
                          December 31, 1996 and 1995

<TABLE>
<CAPTION>
<S>                                                                            <C>                 <C>
                                                                                 1996                1995
                                    ASSETS                                      --------           --------
Current Assets

Cash                                                                              ***                 ***
Investment in GmbH
  Refundable value added tax
  Accounts receivable
  BMBF Grant

Other current assets and prepaid expenses                                     -----------------------------
           Total current assets                                               -----------------------------

Fixed assets (net of accumulated depreciation of $328,191 in 1996
    and 133,965 in 1995)

Organizational costs (net of accumulated
    amortization of $22,000 in 1996 and $14,000 in 1995)

Note receivable from officer (Note I)

Other assets
           Total assets                                                       -----------------------------
                                                                              =============================
     LIABILITIES AND STOCKHOLDERS' EQUITY (DEFICIT)

Current Liabilities
   Accounts payable and accrued expenses

Long term debt (Note E)

Stockholders' equity (Note F):
     Series A Convertible Preferred Stock, $0.001 par value;
     1,650,000 shares authorized;
     1,580,000 shares issued and outstanding (liquidation preference $790,000)

     Series B Convertible Preferred Stock, $0.001 par value;
     3,376,666 shares authorized;
     2,333,333 shares issued and outstanding (liquidation preference
      $3,500,000)

     Common Stock, $0.001 par value; 5,726,700 shares authorized;
     148,251 and 1 shares issued and outstanding in 1995 and 1994,
      respectively

     Additional-paid-in capital

     Cumulative translation adjustment

     Deficit accumulated in the development stage

     Total stockholders' equity (deficit)                                     -----------------------------

     Total liabilities and stockholders' equity (deficit)                     -----------------------------
                                                                              =============================
</TABLE>
   The accompanying notes are an integral part of the financial statements.

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.


<PAGE>

DRAFT                            SEQUENOM, INC.

                        (A Development Stage Enterprise)

                     CONSOLIDATED STATEMENT'S OF OPERATIONS

<TABLE>
<CAPTION>
<S>                                                                             <C>                  <C>
                                                                                    YEAR ENDED          YEAR ENDED
                                                                                DECEMBER 31, 1996    DECEMBER 31, 1995
                                                                                _________________    _________________

Income                                                                                 ***
Research & Development Grant                                                    _________________
Other income                                                                    _________________


Operating Expenses:
Research and development                                                                                    ***
General and administrative expenses                                             --------------------------------------
                                                                                --------------------------------------

Net loss from Operations

Interest income
Interest expense
foreign currency transaction gain Loss
                                                                                _________________    _________________
Net loss                                                                        =================    =================
</TABLE>


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                  EXHIBIT 4.5
                                  -----------

                            Undisclosed Liabilities
                            -----------------------
None.
<PAGE>

                                  EXHIBIT 4.6

                        Changes Since December 31, 1996
                        -------------------------------

None.
<PAGE>

                                  EXHIBIT 4.7
                                  -----------

                                  Encumbrances
                                  ------------


     None, other than non-consensual liens arising in the ordinary course of
business by operation of law. The Corporation is not aware of the existence of
any such liens.
<PAGE>

                                  EXHIBIT 4.8
                                  -----------


                          Intellectual Property Rights


1.  See attached listing of "US patents/patent applications assigned or to be
assigned to Sequenom, Inc." updated as of May 5, 1997.  Further negotiations may
be required to obtain assignments of, or rights to use, the patents and patent
applications designated on such listing as not yet assigned to the Corporation.

2.  Reference is made to the Assignment of Inventions agreement dated May 26,
1994 between Sequenom, Inc. and Dr. Hubert Koster, a copy of which has been made
available to the Investors.

3.  Reference is made to the enclosed Consulting Agreement dated September 6,
1996 between Sequenom, Inc. and Dr. Hubert Koster, a copy of which has been made
available to the Investors.

4.  Reference is made to the Executive Employment Agreement dated April 1, 1994
between Sequenom, Inc. and Dr. Hubert Koster, a copy of which has been made
available to the Investors.

5.  With respect to royalties or other amounts payable by the Corporation to
third parties in relation to Intellectual Property Rights, reference is made to
the agreements listed under Item 4.13(i) of Exhibit 4.13.  In addition, the
                                            ------------
Corporation could be required to pay royalties or deliver other consideration as
a result of the negotiations referred to in Item 1 above.
<PAGE>

                   U.S. PATENTS/PATENT APPLICATIONS ASSIGNED
                   -----------------------------------------
                      OR TO BE ASSIGNED TO SEQUENOM, INC.
                      -----------------------------------




                                      ***



     /***/  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                   U.S. PATENTS/PATENT APPLICATIONS ASSIGNED
                   -----------------------------------------
                      OR TO BE ASSIGNED TO SEQUENOM, INC.
                      -----------------------------------



                                      ***





     /***/  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                   U.S. PATENTS/PATENT APPLICATIONS ASSIGNED
                   -----------------------------------------
                      OR TO BE ASSIGNED TO SEQUENOM, INC.
                      -----------------------------------



                                      ***








     /***/  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                  EXHIBIT 4.13
                                  ------------

                              Material Agreements
                              -------------------


Item 4.13 (c)

1.  Employment agreement dated September 6, 1996 between Sequenom, Inc. and
Fareed Kureshy.

2.  Consulting Agreement dated September 6, 1996 between Sequenom, Inc. and Dr.
Hubert Koster; Executive Employment Agreement dated April 1, 1994 between
Sequenom, Inc. and Dr. Hubert Koster.

3.  Scientific Advisory Board Agreement dated September 6, 1996 between
Sequenom, Inc. and Dr. Hubert Koster.

4.  Consulting Agreement dated December 16, 1996 between Sequenom, Inc. and
Thomas A. Bologna.

5.  Consulting Services Agreement dated April 1, 1994 between Sequenom, Inc. and
Charles Cantor.

6.  Consulting Services Agreement dated April 1, 1994 between Sequenom, Inc. and
Robert Cotter.

7.  Consulting Services Agreement dated October 4, 1996 between Sequenom, Inc.
and Prof.  Dr. Franz Hillenkamp.

8.  Consulting Services Agreement dated February 17, 1997 between Sequenom, Inc.
and Prof.  Dr. Ulf B. Gobel.


Item 4.13 (d)

1.  The Corporation maintains the 1994 Stock Plan.  The Plan provides for the
grant of options to purchase Common Stock and the issuance of shares of Common
Stock to employees, officers, directors and consultants to the Corporation.

2.  The Corporation provides health and dental insurance to all of its full-time
employees through a policy with the Guardian Insurance Company.
<PAGE>

                                  EXHIBIT 4.13
                                  ------------

                         Material Agreements, continued


Item 4.13 (e)

1.  Grid Promissory Note dated March 21, 1997 for up to DM 5,000,000 between the
Corporation and its wholly-owned subsidiary, Sequenom Instruments GmbH.

2.  "Kooperationsvertrag" (Cooperation Agreement) between Sequenom, Inc. and
Technologie Beteiligung Gesellschaft mbH der Deutschen Ausgleichsbank ("tbg")
related to a silent partnership loan of DM 1 million to the company's wholly-
owned subsidiary Sequenom Instruments GmbH dated May, 1995.

3.  "Kooperationsvertrag" (Cooperation Agreement) between Sequenom, Inc. and
Technologie Beteiligung Gesellschaft mbH der Deutschen Ausgleichsbank ("tbg")
related to a silent partnership loan of DM 3 million to the company's wholly-
owned subsidiary Sequenom Instruments GmbH dated December, 1995.


Item 4.13 (g)

1.  Global Master Rental Agreement between Sequenom, Inc. and Comdisco, Inc.

2.  Standard Industrial Gross Lease for office and development space in San
Diego between Sequenom, Inc. and Sorrento Business Complex.


Item 4.13 (i)

1.  Sponsored Research Agreement dated September 15, 1994 between Sequenom, Inc.
and the Trustees of Boston University.

2.  Termination Letter dated February 5, 1997 with respect to the Sponsored
Research Agreement dated September 15, 1994 between Sequenom, Inc. and the
Trustees of Boston University.

3.  Research Agreement dated October 1, 1994 between Sequenom, Inc. and the
Johns Hopkins University.

4.  Amendment No. 1 dated October 23, 1995 to Research Agreement dated October
1, 1994 between Sequenom, Inc. and the Johns Hopkins University.

5.  Patent and Know-How License Agreement dated June 1, 1996 between Sequenom,
Inc. and the Trustees of Boston University.
<PAGE>

                                  EXHIBIT 4.13
                                  ------------

                         Material Agreements, continued


6.  Patent Sublicense Agreement dated November 19, 1996 between Sequenom, Inc.
and Protogene Laboratories, Inc.

7.  Confidentiality/Material Transfer Agreement dated December 1, 1995 between
Sequenom, Inc. and Becton, Dickinson and Company.

8.  Sponsored Research Agreement dated July 1, 1996 between Sequenom, Inc. and
the Korea Advanced Institute of Science and Technology ("KAIST").

9.  License Agreement between Sequenom, Inc. and the Johns Hopkins University,
as contemplated by item 3 above (negotiated but not yet executed by the
parties).

                                     * * *

10.  The Corporation's wholly-owned subsidiary, Sequenom Instruments GmbH, has
the following material agreements relating to loans and grants:

     .  Beteiligungsvertrag (Investment Contract) between Sequenom Instruments
GmbH and Technologie Beteiligung Gesellschaft mbH der Deutschen Ausgleichsbank
("tbg") for a silent partnership loan of DM 3 million dated May, 1995.

     .  Beteiligungsvertrag (Investment Contract) between Sequenom Instruments
GmbH and Technologie Beteiligung Gesellschaft mbH der Deutschen Ausgleichsbank
("tbg') for a silent partnership loan of DM 3 million dated December, 1995.

     .  Zuwendung aus dem Bundeshaushalt (Federal Budget Grant) dated August 17,
1995 for the co-operative project "High Speed DNA Sequencing and DNA Diagnostics
with the Help of Mass Spectrometry" from the Bundesministerium fr Bildung,
Wissenschaft, Forschung und Technologie (the Ministry for Education, Science,
Research and Technology) in the amount of DM 2.2 million.

     .  Foderantrag (Grant Application) for the period October 1, 1995 to
December 31, 1998 for the co-operative project High Speed DNA Sequencing and DNA
Diagnostics with the Help of Mass Spectrometry with the Freie und Hansestadt
Hamburg Wirtschaftbehorde (the Trade Bureau of the City/State of Hamburg) in the
amount of DM 800,000.
<PAGE>

                                  EXHIBIT 4.15
                                  ------------

                                   Insurance
                                   ---------

1.   St. Paul Fire and Marine Insurance Company
     Policy Period: October 26, 1996-October 26, 1997
     Premium $ 3,825
     Policy number: FK06603871

     Commercial General Liability Limits:
          Each event: $2 million
          Premises: $1,000,000
          Medical expenses: $5,000
          Personal injury and advertising injury: $2,000,000
          General Total: $4,000,000

     Loss of Earnings and Extra Expense Coverage, Limit: $500,000

     Non-owned auto: $2,000,000

     Business Contents Limits:  San Diego:   $600,000
                                Boston:      $  5,000

2.   Zenith Insurance Company
     Policy Period: October 1, 1996-October 1, 1997
     Premium: $10,817
     Policy number: Z042591701
     Workers Compensation Insurance
     Employers Liability Insurance
     Limits:   Bodily Injury by Accident:    $1,000,000 each accident
               Bodily Injury by Disease:     $1,000,000 each employee
               Bodily Injury by Disease:     $1,000,000 Policy Limit

3.   The Corporation also maintains life insurance coverage on Dr. Hubert Koster
     in the amount of $1 million ($500,000 in term insurance and $500,000 in
     whole life insurance). The Corporation is beneficiary of both of these
     policies.
<PAGE>

                                 EXHIBIT 4-l-6A

                     Form of Registration Rights Agreement
                     -------------------------------------
<PAGE>

                         REGISTRATION RIGHTS AGREEMENT

     This Registration Rights Agreement is entered into as of May __,1997 by and
among Sequenom, Inc., a Delaware corporation (the "Corporation"); the holders
(the "Series B Investors") of shares of the Corporation's Series B Convertible
Preferred Stock, $.001 par value per share (the Series B Preferred Stock"); and
the purchasers of shares of the Corporation's Series C Convertible Preferred
Stock, par value $.001 per share (the "Series C Preferred Stock"), pursuant to
the Series C Convertible Preferred Stock Purchase Agreement dated as of the date
hereof (the "Purchase Agreement"), including any Additional Investors as defined
in the Purchase Agreement (such purchasers of Series C Preferred Stock being
hereinafter sometimes referred to individually as an "Investor" and collectively
as the "Investors").

     WHEREAS, the Corporation and the Series B Investors are the parties to a
Registration Rights Agreement dated as of December 22, 1995 (the "Prior
Registration Rights Agreement"), pursuant to which the Corporation granted
certain registration rights to the Series B Investors and certain of their
transferees;

     WHEREAS, the Corporation now wishes to sell to the Investors certain shares
of its Series C Preferred Stock and certain warrants to purchase shares of its
Series C Preferred Stock;

     WHEREAS, the Series B Preferred Stock and the Series C Preferred Stock are
convertible into shares of the Corporation's Common Stock; and

     WHEREAS, as a condition to entering into the Purchase Agreement, the
Investors have required that the Corporation and the Series B Investors execute
this Agreement to provide the Investors rights to register the shares of Common
Stock issuable upon conversion of their Series C Preferred Stock and certain
other securities of the Corporation described below;

     NOW, THEREFORE, in consideration of the premises and the mutual agreements
hereinafter set forth, the parties hereto agree as follows:

     1.  Definitions.  As used in this Agreement, the following terms shall have
         -----------
the following meanings:

     (a) The term "Act" means the Securities Act of 1933, as amended;

     (b) The term "Holder" means any Investor, any Series B Investor and any
other person or entity holding Registrable Securities to whom the registration
rights granted in this Agreement have been transferred pursuant to Section 14
hereof;

     (c) The term "Preferred Stock" means the Series B Preferred Stock and the
Series C Preferred Stock;

     (d) The terms "register," "registered," and "registration" refer to a
registration effected by preparing and filing a registration statement in
compliance with the Act and the declaration or ordering of effectiveness of such
registration statement; and
<PAGE>

     (e) The term "Registrable Securities" means (1) the Common Stock issuable
upon conversion of the Preferred Stock, (2) Common Stock purchased by an
Investor pursuant to Section 8.1 of the Purchase Agreement (or Common Stock for
or into which New Securities (as therein defined) purchased by the Investor
pursuant to such Section 8.1 may be exercised or converted) or pursuant to the
Stock Restriction Agreement dated as of the date hereof among the Corporation,
the Series B Investors, the Investors and certain additional parties identified
therein, and (3) any Common Stock of the Corporation issued as a dividend or
other distribution with respect to, or in exchange or in replacement of, such
Preferred Stock or Common Stock.

     In addition, for purposes of all calculations and notices under this
Agreement, and all other provisions of this Agreement where the context permits,
the term "Registrable Securities" shall include securities issuable upon
conversion of the Preferred Stock, a holder of the Preferred Stock shall be
deemed the Holder of such securities and such securities shall be deemed
outstanding Registrable Securities hereunder.  Notwithstanding the foregoing,
nothing in this Agreement shall require the Corporation actually to register any
shares of the Preferred Stock.

     2.  Request for Registration.  If at any time after the earlier of (i) the
         ------------------------
first underwritten public offering of securities for the account of the
Corporation, and (ii) the date three (3) years from the date hereof, the
Corporation shall receive a written request (specifying that it is being made
pursuant to this Section 2) from the Holder or Holders at least fifty percent
(50%) of the then outstanding Registrable Securities that the Corporation file a
registration statement under the Act, or a similar document pursuant to any
other statute then in effect corresponding to the Act, covering the registration
of at least the lesser of (i) at least twenty-five percent (25%) of the then
outstanding Registrable Securities and (ii) Registrable Securities the expected
price to the public of which equals or exceeds $10,000,000, then the Corporation
shall promptly notify all other Holders of such request and shall use its best
efforts to cause all Registrable Securities that Holders have requested be
registered to be registered under the Act.

     Notwithstanding the foregoing, (a) the Corporation shall not be obligated
to effect a registration pursuant to this Section 2 during the period starting
with the date sixty (60) days prior to the Corporation's estimated date of
filing of, and ending on a date six (6) months following the effective date of,
a registration statement pertaining to an underwritten public offering of
securities for the account of the Corporation, provided that the Corporation is
actively employing in good faith its best efforts to cause such registration
statement to become effective and that the Corporation's estimate of the date of
filing such registration statement is made in good faith; (b) the Corporation
shall not be obligated to effect a registration pursuant to this Section 2
within six (6) months after the effective date of a prior registration under
such Section; (c) if the Corporation shall furnish to the Holders a certificate
signed by the President of the Corporation stating that in the good faith
judgment of the Board of Directors it would be seriously detrimental to the
Corporation or its shareholders for a registration statement to be filed in the
near future, then the Corporation's obligation to use its best efforts to file a
registration statement shall be deferred for a period not to exceed three (3)
months; and (d) the Corporation may postpone a registration pursuant to this
election for such period of time as may be required to permit the use of regular
audited year-end financial statements with supplemental short period figures for
a period not exceeding six (6) months unless the Holders agree to bear the costs
of any special audit.

                                       2
<PAGE>

     The Corporation shall not be obligated to effect more than two (2)
registrations pursuant to this Section 2. Any request for registration under
this Section 2 must be for a for a firm commitment underwritten public offering
to be managed by an underwriter or underwriters of recognized national standing
reasonably acceptable to the Corporation.

     3.  Corporation Registration.  Subject to Section 8 of this Agreement, if
         ------------------------
at any time the Corporation proposes to register any of its Common Stock under
the Act in connection with the public offering of such securities for its own
account or for the accounts of other shareholders, solely for cash on a form
that would also permit the registration of the Registrable Securities, the
Corporation shall, each such time, promptly give each Holder written notice of
such determination.  Upon the written request of any Holder given within thirty
(30) days after mailing of any such notice by the Corporation, the Corporation
shall, subject to the limitations set forth in Section 8(a), use its best
efforts to cause to be registered under the Act all of the Registrable
Securities that each such Holder has requested be registered.

     4.  Obligations of the Corporation.  Whenever required under Section 2, 3,
         ------------------------------
or 11 to use its best efforts to effect the registration of any Registrable
Securities, the Corporation shall, as expeditiously as reasonably possible:

     (a) Prepare and file with the Securities and Exchange Commission ("SEC") a
registration statement with respect to such Registrable Securities and use its
best efforts to cause such registration statement to become and remain
effective; provided, however, that in connection with any proposed registration
intended to permit an offering of any securities from time to time (i.e., a so-
called "shelf registration"), the Corporation shall in no event be obligated to
cause any such registration to remain effective for more than one hundred eighty
(180) days.

     (b) Prepare and file with the SEC such amendments and supplements to such
registration statement and the prospectus used in connection with such
registration statement as may be necessary to comply with the provisions of the
Act with respect to the disposition of all securities covered by such
registration statement.

     (c) Furnish to the Holders such numbers of copies of a prospectus,
including a preliminary prospectus, in conformity with the requirements of the
Act, and such other documents as they may reasonably request in order to
facilitate the disposition of Registrable Securities owned by them.

     (d) Use its best efforts to register and qualify the securities covered by
such registration statement under such other securities or Blue Sky laws of such
jurisdictions as shall be reasonably appropriate for the distribution of the
securities covered by the registration statement, provided that the Corporation
shall not be required in connection therewith or as a condition thereto to
qualify to do business or to file a general consent to service of process in any
such states or jurisdictions, and further provided that (anything in this
Agreement to the contrary notwithstanding with respect to the bearing of
expenses) if any jurisdiction in which the securities shall be qualified shall
require that expenses incurred in connection with the qualification of the
securities in that jurisdiction be borne by selling shareholders, then such
expenses shall be payable by selling shareholders pro rata, to the extent
required by such jurisdiction.

                                       3
<PAGE>

     (e) Provide a transfer agent for the Common Stock no later than the
effective date of the first registration of any Registrable Securities.

     5.  Furnish information.  It shall be a condition precedent to the
         -------------------
obligations of the Corporation to take any action pursuant to this Agreement
that the Holders shall furnish to the Corporation such information regarding
them, the Registrable Securities held by them, and the intended method of
disposition of such securities as the Corporation shall reasonably request and
as shall be required in connection with the action to be taken by the
Corporation.

     6.  Expenses of Demand Registration.  All expenses incurred in connection
         -------------------------------
with registrations pursuant to Section 2 (excluding underwriters' discounts and
commissions), including, without limitation, all registration and qualification
fees, printers, and accounting fees, fees and disbursements of counsel for the
Corporation, and the reasonable fees and disbursements of one special counsel
for the selling Holders, shall be borne by the Corporation.

     7.  Corporation Registration Expenses.  All expenses (excluding
         ---------------------------------
underwriters' discounts and commissions) incurred in connection with a
registration pursuant to Section 3, including, without limitation, any
additional registration and qualification fees and any additional fees and
disbursements of counsel to the Corporation that result from the inclusion of
securities held by the Holders in such registration and the reasonable fees and
disbursements of one special counsel for the selling stockholders, shall be bore
by the Corporation; provided, however, that if the registration is of
exclusively a secondary offering, the holders shall bear their proportionate
share of the expenses incurred in connection with any registration (provided all
shareholders registering shares thereunder bear their proportionate share of
expenses), except expenses which the Corporation would have incurred whether or
not the securities held by the Holders were included in such registration
(including, without limitation, the expense of preparing normal audited or
unaudited financial statements).

     8.  Underwriting Requirements.
         -------------------------

     (a) In connection with any offering involving an underwriting of shares
being issued by the Corporation, the Corporation shall not be required under
Section 3 to include any of the Holders' Registrable Securities in such
underwriting unless they accept the terms of the underwriting as agreed upon
between the Corporation and the underwriters selected by it, and then only in
such quantity as will not, in the reasonable opinion of the underwriters,
jeopardize the success of the offering by the Corporation.  If the total amount
of securities that all Holders request to be included in an underwritten
offering exceeds the amount of securities that the underwriters reasonably
believe compatible with the success of the offering, the Corporation shall only
be required to include in the offering so many of the securities of the selling
Holders as the underwriters reasonably believe will not jeopardize the success
of the offering (the securities so included to be apportioned pro rata among the
selling Holders according to the total amount of securities owned by said
selling Holders, or in such other proportions as shall mutually be agreed to by
such selling Holders), provided that in the case of an offering involving shares
being issued by the Corporation, no such reduction shall be made with respect to
any securities offered by the Corporation for its own account, and provided
further that no securities of any shareholder who is not a Holder shall be
included in such offering, other than securities of shareholders who have
initiated such registration pursuant to the exercise of contractual rights to

                                       4
<PAGE>

do so, unless all securities which the Holders have requested to be included are
included on a pro rata basis with the securities of any other shareholders who
have a contractual right to include their securities in such offering.

     (b) With respect to any underwriting of shares to be registered under
Section 2, or an underwriting of shares to be registered under Section 11 if the
Holders of a majority of the then outstanding Registrable Securities have
requested registration thereunder, such Holders shall have the right to
designate the managing underwriter or underwriters, subject to the consent of
the Corporation.  In all other circumstances under such Sections and in
connection with registrations under Section 3, the Corporation shall have the
right to designate the managing underwriter or underwriters, subject to the
consent of the Holders of a majority of the Registrable Securities participating
in the underwriting.  In any such case, such consent shall not be unreasonably
withheld or delayed.

     9.  Delay of Registration.  No Holder shall have any right to take any
         ---------------------
action to restrain, enjoy, or otherwise delay any registration as the result of
any controversy that might arise with respect to the interpretation or
implementation of this Agreement.

     10.  Indemnification.  In the event any Registrable Securities are included
          ---------------
in a registration statement under this Agreement:

     (a) To the extent permitted by law, the Corporation will indemnify and hold
harmless each Holder requesting or joining in a registration, any underwriter
(as defined in the Act) for it, and each person, if any, who controls such
Holder or underwriter within the meaning of the Act, against any losses, claims,
damages or liabilities, joint or several, to which they may become subject under
the Act or otherwise, insofar as such losses, claims, damages or liabilities (or
actions in respect thereof) arise out of or are based on any untrue or alleged
untrue statement of any material fact contained in such registration statement,
including, without limitation, any preliminary prospectus or final prospectus
contained therein or any amendments or supplements thereto, or arise out of or
are based upon the omission or alleged omission to state therein a material fact
required to be stated therein, or necessary to make the statements therein not
misleading or arise out of any violation by the Corporation of any rule or
regulation promulgated under the Act applicable to the Corporation and relating
to action or inaction required of the Corporation in connection with any such
registration; and will reimburse each such Holder, such underwriter, or
controlling person for any legal or other expenses reasonably incurred by them
in connection with investigating or defending any such loss, claim, damage,
liability, or action, provided, however, that the indemnity agreement contained
in this Section 10(a) shall not apply to amounts paid in settlement of any such
loss, claim, damage, liability or action if such settlement is effected without
the consent of the Corporation (which consent shall not be unreasonably withheld
or delayed) nor shall the Corporation be liable in any such case for any such
loss, claim, damage, liability or action to the extent that it arises out of or
is based upon an untrue statement or alleged untrue statement or omission or
alleged omission made in connection with such registration statement,
preliminary prospectus, final prospectus, or amendments or supplements thereto,
in reliance upon and in conformity with written information furnished expressly
for use in connection with such registration by any such Holder, underwriter or
controlling person.

                                       5
<PAGE>

     (b) To the extent permitted by law, each Holder requesting or joining in a
registration will indemnify and hold harmless the Corporation, each of its
directors, each of its officers who has signed the registration statement, each
person, if any, who controls the Corporation within the meaning of the Act, and
any underwriter for the Corporation (within the meaning of the Act) against any
losses, claims, damages or liabilities to which the Corporation or any such
director, officer, controlling person or underwriter may become subject, under
the Act or otherwise, insofar as such losses, claims, damages or liabilities (or
actions in respect thereto) arise out of or are based upon any untrue statement
or alleged untrue statement of any material fact contained in such registration
statement, including any preliminary prospectus or final prospectus contained
therein or any amendments or supplements thereto, or arise out of or are based
upon the omission or alleged omission to state therein a material fact required
to be stated therein or necessary to make the statements therein not misleading,
in each case to the extent, but only to the extent, that such untrue statement
or alleged untrue statement or omission or alleged omission was made in such
registration statement, preliminary prospectus or final prospectus, or
amendments or supplements thereto, in reliance upon and in conformity with
written information furnished by such Holder expressly for use in connection
with such registration; and will reimburse the Corporation or any such director,
officer, controlling person or underwriter for any legal or other expenses
reasonably incurred by them in connection with investigating or defending any
such loss, claim, damage, liability or action; provided, however, that the
indemnity agreement contained in this Section 10(b) shall not apply to amounts
paid in settlement of any such loss, claim, damage, liability or action if such
settlement is effected without the consent of such Holder (which consent shall
not be unreasonably withheld) and provided further that no Holder shall have any
liability under this Section 10(b) in excess of the net proceeds actually
received by such Holder in the relevant public offering.

     (c) Promptly after receipt by an indemnified party under this Section 10 of
notice of the commencement of any action, such indemnified party will, if a
claim in respect thereof is to be made against any indemnifying party under this
Section 10, notify the indemnifying party in writing of the commencement thereof
and the indemnifying party shall have the right to participate in, and, to the
extent the indemnifying party so desires, jointly with any other indemnifying
party similarly noticed, to assume the defense thereof with counsel mutually
satisfactory to the parties.  The failure to notify an indemnifying party
promptly, of the commencement of any such action, if prejudicial to his ability
to defend such action, shall relieve such indemnifying party of any liability to
the indemnified party under this Section 10, but the omission so to notify the
indemnifying party will not relieve him of any liability that he may have to any
indemnified party otherwise than under this Section 10.

     11.  Registrations on Form S-3.
          -------------------------

     (a) If (i) the Corporation shall receive a written request (specifying that
it is being made pursuant to this Section 11) from the Holder or Holders of at
least twenty-five percent (25%) of the then outstanding Registrable Securities
that the Corporation file a registration statement on Form S-3 (or any successor
form to Form S-3 regardless of its designation) for a public offering of shares
of the Registrable Securities the reasonably anticipated aggregate price to the
public of which would exceed Two Million Dollars ($2,000,000), and (ii) the
Corporation is a registrant entitled to use Form S-3 to register such shares,
then the Corporation shall use its

                                       6
<PAGE>

best efforts to cause such shares to be registered on Form S-3 (or any successor
form to Form S-3).

     (b) All expenses (excluding underwriters' discounts and commissions)
incurred in connection with the first two registrations requested pursuant to
Section 11(a), including, without limitation, all registration, qualification,
printing, and accounting fees, and fees and disbursements of one special counsel
to the selling Holder or Holders and counsel to the Corporation, shall be borne
by the Corporation.  All such expenses for registrations pursuant to Section
11(a) after the first two such registrations shall be borne by the Corporation,
except that the selling Holders shall pay all fees of their legal counsel, if
any, in connection therewith.

     (c) Holders' rights to registration under this Section 11 are in addition
to, and not in lieu of, their rights to registration under Sections 2 and 3 of
this Agreement.

     12.  Reports Under Securities Exchange Act of 1934.  With a view to making
          ---------------------------------------------
available to the Holders the benefits of Rule 144 promulgated under the Act and
any other rule or regulation of the SEC that may at any time permit a Holder to
sell securities of the Corporation to the public without registration, the
Corporation agrees to use its best efforts to:

     (a) make and keep public information available, as those terms are
understood and defined in Rule 144, at all times subsequent to ninety (90) days
after the effective date of the first registration statement covering an
underwritten public offering filed by the Corporation;

     (b) file with the SEC in a timely manner all reports and other documents
required of the Corporation under the Act and the Securities Exchange Act of
1934, as amended (the "1934 Act"); and

     (c) furnish to any Holder forthwith upon request a written statement by the
Corporation that it has complied with the reporting requirements of Rule 144 (at
any time after ninety (90) days after the effective date of said first
registration statement filed by the Corporation), and of the Act and the 1934
Act (at any time after it has become subject to such reporting requirements), a
copy of the most recent annual or quarterly report of the Corporation, and such
other reports and documents so filed by the Corporation as may be reasonably
requested in availing any such holder to take advantage of any rule or
regulation of the SEC permitting the selling of any such securities without
registration.

     13.  Limitations in Connection with Future Grants of Registration Rights.
          -------------------------------------------------------------------
Without the prior written consent of the Holder or Holders of a majority of the
then outstanding Registrable Securities issued or issuable upon conversion of
the Preferred Stock, the Corporation shall not grant rights to cause the
Corporation to register any of its securities to any person or entity other than
the Additional Investors as contemplated hereunder.

     14.  Transfer of Registration Rights.  The registration rights of any
          -------------------------------
Investor (and of any permitted transferee of any Investor or its permitted
transferees) under this Agreement with respect to any shares of Registrable
Securities may be transferred to any Affiliate of such Investor or such
permitted transferee, or to any transferee who acquires (otherwise than in a
registered public offering) at least five percent (5%) of the Registrable
Securities held or acquired as of the date hereof by such Investor, provided,
however, that the Corporation is given
<PAGE>

written notice by the Holder at the time of such transfer stating the name and
address of the transferee and identifying the securities with respect to which
the rights under this Agreement are being assigned. For such purpose, an
"Affiliate" of any Investor (or any such transferee) means any partner of such
Investor (or transferee) if it is a partnership, or any person or entity that,
directly or indirectly, through one or more intermediaries, controls, or is
controlled by, or is under common control with, such Investor or transferee.

     15.  Mergers, Etc.  The Corporation shall not, directly or indirectly,
          ------------
enter into any merger, consolidation or reorganization in which the Corporation
shall not be the surviving corporation unless the proposed surviving corporation
shall, prior to such merger, consolidation or reorganization, agree in writing
to assume the obligations of the Corporation under this Agreement, and for that
purpose references hereunder to "Registrable Securities" shall be deemed to be
references to the securities which the Holders would be entitled to receive in
exchange for Registrable Securities under any such merger, consolidation or
reorganization; provided, however, that the provisions of this Agreement shall
not apply in the event of any merger, consolidation or reorganization in which
the Corporation is not the surviving corporation if the Holders of Registrable
Securities are entitled to receive in exchange therefor (i) cash, or (ii)
securities of the acquiring corporation which may be immediately sold to the
public without registration under the Act.

     16.  Stand-Off Agreement.  Each Holder, if requested by the Corporation and
          -------------------
the managing underwriter of an offering by the Corporation of Common Stock or
other securities of the Corporation pursuant to a registration statement under
the Act, shall agree not to sell publicly or otherwise transfer or dispose of
any Registrable Securities or other securities of the Corporation held by such
Holder for a specified period of time (not to exceed 180 days) following the
effective date of such registration statement; provided, that:
                                               --------

     (a) such agreement shall only apply to the first registration statement
covering Common Stock to be sold on the Corporation's behalf to the public in an
underwritten offering; and

     (b) all holders of five percent (5%) or more of the shares of Common Stock
then outstanding (including shares of Common Stock issuable upon the conversion
of Preferred Stock, or other convertible securities, or upon the exercise of
options, warrants or rights) and all officers and directors of the Corporation
enter into similar agreements.

     17.  Accession.  Any Additional Investors as defined in the Purchase
          ---------
Agreement shall automatically become an Investor hereunder by delivering to the
Corporation a written instrument in the form of Exhibit A hereto, by which such
                                                ---------
Additional Investor agrees to be bound by the obligations imposed under this
Agreement, whereupon such Additional Investor shall automatically become a party
to this Agreement and shall thereupon be deemed an "Investor" for all purposes
of this Agreement.

     18.  Notices.  All notices, requests, consents and other communications
          -------
hereunder to any party shall be deemed to be sufficient if contained in a
written instrument delivered in person or duly sent by first class mail postage
prepaid (other than to non-U.S. parties) or by fax or DHL, Federal Express or
other internationally recognized courier service, addressed to such party at the
<PAGE>

address set forth below or such other address as may hereafter be designated in
writing by the addressee to the addressor listing all parties:

     (i)  if to the Corporation, to:

          Sequenom, Inc.
          11555 Sorrento Valley Road
          Suite C
          San Diego, CA 92121
          Attention: President
          Fax: (619) 350-0344

          with a copy to:

          David R. Pierson, Esq.
          Foley, Hoag & Eliot LLP
          One Post office Square
          Boston, Massachusetts 02109
          Fax:  (617) 832-7000

     (ii) if to the Series B Investors or the Investors (or their respective
          transferees), to their respective last known address or their
          respective address, if any, appearing in the books of the Corporation.

     19.  Miscellaneous.
          -------------

     (a) This Agreement states the entire agreement of the parties concerning
the subject matter hereof, and supersedes all prior agreements, written or oral,
between or among them concerning such subject matter.

     (b) This Agreement may be amended, and compliance with any provision of
this Agreement may be omitted or waived, only by the written agreement of the
Corporation and the Holders of at least eighty-five percent (85%) in voting
power of the then outstanding Registrable Securities issued or issuable upon
conversion of the Preferred Stock to be bound thereby.

     (c) This Agreement supersedes and replaces the Prior Registration Rights
Agreement, which upon execution hereof shall be of no further force or effect.

     (c) This Agreement shall be governed by, and construed and enforced in
accordance with, the substantive laws of The Commonwealth of Massachusetts,
without regard to its principles of conflicts of laws.

     (d) This Agreement may be executed in any number of counterparts, each such
counterpart shall be deemed to be an original instrument, and all such
counterparts together shall constitute but one agreement.  Any such counterpart
may contain one or more signature pages.

                                     * * *

                                       9
<PAGE>

     IN WITNESS WHEREOF, the parties have executed this Registration Rights
Agreement as a contract under seal as of the date first written above.

                                    SEQUENOM, INC.


                                    By: _________________________________
                                         Its President
               SERIES B INVESTORS:
                                    TVM TECHNO VENTURE
                                    ENTERPRISES NO.  II
                                    LIMITED PARTNERSHIP


                                    By:  TVM Techno Venture Management Limited
                                         Partnership
                                           its General Partner
                                    By:  TVM Management Corporation
                                           its General Partner

                                    By: _________________________________
                                         Name:
                                         Title:
<PAGE>

                                    TVM INTERTECH LIMITED PARTNERSHIP

                                    By:  TVM Techno Venture Management
                                         Limited Partnership
                                            its General Partner

                                    By:  TVM Management Corporation
                                            its General Partner

                                    By:    /s/ illegible
                                        ------------------------------------
                                           Its:

                                    TVM ZWEITE BETEILIGUNG-US LIMITED
                                    PARTNERSHIP

                                    By:  TVM Techno Venture Management
                                         Limited Partnership
                                            its General Partner

                                    By:  TVM Management Corporation
                                            its General Partner

                                    By:    /s/ illegible
                                        ------------------------------------
                                           Its:
<PAGE>

                                    TVM EUROTECH LIMITED
                                    PARTNERSHIP

                                    By:  TVM Techno Venture Management
                                         Limited Partnership
                                          its General Partner
                                    By:  TVM Management Corporation
                                          its General Partner


                                    By: __________________________________
                                        Its:


                                    TVM TECHNO VENTURE
                                    INVESTORS NO. 1 LIMITED
                                    PARTNERSHIP


                                    By: __________________________________
                                        General Partner


                                    ***

                                    ALPINVEST INTERNATIONAL B.V.


                                    By: __________________________________
                                        Its:

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                    ***

                                    ______________________________________
                                    Hubert Koster


                                    ______________________________________
                                    Ernst-Gunter Afting

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                              ***

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                 SEQUENOM, INC.

                         Registration Rights Agreement

                            Investor Signature Page
                            -----------------------

     By executing this page in the space provided, the undersigned hereby agrees
(i) that it is an "Investor" as defined in the Registration Rights Agreement
dated as of May ___, 1997, by and among Sequenom, Inc. and the parties named
therein, (ii) that it is a party to the Registration Rights Agreement for all
purposes and (iii) that it is bound by all terms and conditions of the
Registration Rights Agreement.

EXECUTED this ___ day of May, 1997.



                                           ____________________________________
                                           (print name)

                                           By: ________________________________

                                           Title: _____________________________

                                           Address:____________________________

                                           ____________________________________

                                           ____________________________________

                                           ____________________________________

<PAGE>

                                                                       Exhibit A
                                                                       ---------

                                 SEQUENOM, INC.
                         Registration Rights Agreement

                       Additional Investor Signature Page
                       ----------------------------------


     By executing this page in the space provided, the undersigned agrees (i)
that it is an "Additional Investor" as defined in the Series C Convertible
Preferred Stock Purchase Agreement dated as of May 8, 1997 and an "Investor" as
defined in the Registration Rights Agreement dated as of May 8, 1997, each by
and among Sequenom, Inc. and the parties named therein, (ii) that it is a party
to the Registration Rights Agreement for all purposes and (iii) that it is bound
by all terms and conditions of the Registration Rights Agreement.


     EXECUTED this ____ day of ________________, 1997.


                                    ____________________________________
                                    (print name)


                                    By: ________________________________

                                    Title: _____________________________

                                    Address: ___________________________
<PAGE>

                                 EXHIBIT 4.16B
                                 -------------


                            Form of Voting Agreement
                            ------------------------

<PAGE>

                               VOTING AGREEMENT

     Agreement made as of May ___, 1997 by and among Sequenom, Inc., a Delaware
corporation (the "Corporation"); Hubert Koster, Nola E. Masterson and Robert E.
Patterson (the "Founders"); TVM Techno Venture Enterprises No. II Limited
Partnership, TVM Intertech Limited Partnership, TVM Zweite Beteiligung-U.S.
Limited Partnership, TVM Eurotech Limited Partnership, TVM Techno Venture
Investors No. 1 Limited Partnership and *** (the "Original Investors"); the
holders (the "Series B Investors") of shares of the Corporation's Series B
Convertible Preferred Stock, $.001 par value per share (the "Series B Preferred
Stock"); and the purchasers of shares of the Corporation's Series C Convertible
Preferred Stock, $.001 par value per share ("Series C Preferred Stock"),
pursuant to the Series C Convertible Preferred Stock Purchase Agreement dated as
of the date hereof (the "Purchase Agreement"), including any Additional
Investors as defined in the Purchase Agreement (all such purchasers of Series C
Preferred Stock under the Purchase Agreement being referred to as the
"Investors," and all such Founders, Original Investors, Series B Investors and
Investors being referred to as the "Stockholders").

                                   AGREEMENT
                                   ---------

     In consideration of the mutual covenants herein contained, the parties
hereto agree as follows:

     1.  Board of Directors.  The Stockholders agree to vote all shares of the
         ------------------
Corporation's Common Stock, $.001 par value per share ("Common Stock"), Series A
Convertible Preferred Stock, $.001 par value per share ("Series A Preferred
Stock"), Series B Preferred Stock, Series C Preferred Stock and any other class
of voting security of the Corporation (the "Shares") now or hereafter owned or
controlled by them, and otherwise to use their respective best efforts as
stockholders of the Corporation, to set the number of directors of the
Corporation at seven and to elect as directors, on the date of this Agreement
and in any subsequent election of directors of the Corporation:

     (a)  the Chief Executive Officer of the Corporation (the "CEO Director"),
          who shall initially be Fareed Kureshy;

     (b)  one person designated by the Founders, who shall initially be Hubert
          Koster;

     (c)  one person designated by the Original Investors, who shall initially
          be Helmut Schuhsler;

     (d)  two persons designated by the Series B Investors, who shall initially
          be Thomas Bologna and William Golden; and

     (e)  two persons who are not employees of the Corporation (the "Independent
          Directors"), who have experience in the Corporation's industry and who
          are reasonably acceptable to a majority of the other directors, and
          who shall initially be Nola E. Masterson and Ernst-Gunter Afting.

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

     Any person or entity or group of persons or entities entitled to make a
director designation hereunder (a "Designating Party") shall furnish written
notice to the Stockholders at least 10 days prior to any election of directors
of its director-designee or director-designees.  In the absence of such notice,
the director-designee or director-designees of such Designating Party then
serving and previously designated shall be reelected if still eligible to serve
as provided herein.  In the event that any Designating Party that is a group of
Stockholders cannot agree upon a director-designee, the identity of the
director-designee of such Designating Party shall be determined by a plurality
in voting power of the outstanding capital stock of the Corporation held by the
Stockholders constituting such Designating Party.

     This Agreement is not intended, and shall not be construed, to confer upon
any person designated hereunder for election to the Board of Directors any right
to serve or to continue to serve in such capacity.  Any Designating Party may,
at any time, determine to remove its then-current director-designee and
designate another person for election to the Board of Directors in place of the
person then serving as the director-designee of such Designating Party.  In the
event any such determination is made, the Stockholders shall promptly vote to
remove the director-designee of such Designating Party then serving, and to
elect as a director the replacement director-designee of such Designating Party.

     If at any time the person serving as Chief Executive Officer of the
Corporation shall resign, be removed or otherwise cease to serve as such
officer, the Stockholders shall promptly vote (i) if the former Chief Executive
Officer has not resigned as a director, to remove him as a director, and (ii) to
elect the new Chief Executive Officer of the Corporation as the CEO Director.

     At any time a majority of the directors other than the Independent
Directors may determine to remove any Independent Director from the Board of
Directors and designate another person for election to the Board of Directors in
place of the person then serving as such Independent Director.  In the event any
such determination is made, the Stockholders shall promptly vote to remove the
applicable Independent Director and to elect as a director the replacement
Independent Director designee.

     Any vacancy on the Board of Directors created by the resignation, removal,
incapacity, or death of any person designated under this Section 1 shall be
filled by another person designated by the original Designating Party.  The
Stockholders shall vote their respective Shares in accordance with such new
designation, and any such vacancy shall not be filled in the absence of a new
designation by the original Designating Party.

     This Section 1 shall terminate and be of no further force and effect upon
the closing of a firm commitment underwritten public offering of Common Stock of
the Corporation pursuant to an effective registration statement under the
Securities Act of 1933, as amended, in which the aggregate gross proceeds to the
Corporation from such offering are not less than $20,000,000 and the offering
price per share is not less than $9.45, appropriately adjusted to take account
of any stock split, stock dividend, combination of shares or similar event.

     In the event that any Designating Party (or its or their respective
partners, stockholders and affiliates) owns, in the aggregate, fewer than
200,000 shares of the Corporation's Common

                                       2
<PAGE>

Stock, subject to adjustment for stock splits, stock dividends, combinations of
shares and similar events, such Designating Party's right to make designations
under this Section 1 shall terminate, and the obligation of the other parties
under this Section 1 to vote for any members of the Board of Directors
designated by such Designating Party shall terminate, but all other obligations
of all parties hereunder shall continue unless otherwise terminated. For
purposes of this paragraph, in determining the number of shares of Common Stock
owned by a Designating Party, ownership by such Designating Party of shares of
Series A Preferred Stock, Series B Preferred Stock or Series C Preferred Stock
shall be deemed to be ownership by it of that number of shares of Common Stock
into which such shares of Series A Preferred Stock, Series B Preferred Stock and
Series C Preferred Stock are convertible.

     2.  Director Indemnification.  In the event that any director contemplated
         ------------------------
by this Agreement shall be made or threatened to be made a party to any action,
suit or proceeding with respect to which he may be entitled to indemnification
by the Corporation pursuant to its Certificate of Incorporation, By-Laws or
otherwise, he shall be entitled to be represented in such action, suit or
proceeding by counsel of his choice and the expenses of such representation
shall be reimbursed by the Corporation to the extent provided in or authorized
by said Certificate of Incorporation or other provision and permitted by
applicable law.

     The Corporation and the Stockholders agree not to take any action to amend
any provision of the Certificate of Incorporation or By-Laws of the Corporation
relating to indemnification of directors, as presently in effect, without the
prior written consent of a majority in voting power of the Series B Investors.

     3.  Accession.  Any Additional Investors as defined in the Purchase
         ---------
Agreement shall automatically become an Investor hereunder by delivering to the
Corporation a written instrument in the form of Exhibit A hereto, by which such
                                                ---------
Additional Investor agrees to be bound by the obligations imposed under this
Agreement, whereupon such Additional Investor shall automatically become a party
to this Agreement and shall thereupon be deemed an "Investor" and a
"Stockholder" for all purposes of this Agreement.

     4.  Notices.  All notices, requests, consents and other communications
         -------
hereunder to any party shall be deemed to be sufficient if contained in a
written instrument delivered in person or duly sent by first class mail postage
prepaid (other than to non-U.S. parties), by fax, or by DHL, Federal Express or
any other internationally recognized express courier service, addressed to such
party at the address set forth below or such other address as may hereafter be
designated in writing by the addressee to the addressor listing all parties:

     i)  if to the Corporation, to:

         Sequenom, Inc.
         11555 Sorrento Valley Road
         Suite C
         San Diego, CA 92121
         Attention: President
         Fax: (619) 350-0344

                                       3
<PAGE>

     with a copy to:

          David R. Pierson, Esq.
          Foley, Hoag & Eliot LLP
          One Post office Square
          Boston, Massachusetts 02109
          Fax:  (617) 832-7000

     (ii) if to the Stockholders, to their respective last known address or
their respective address, if any, appearing in the books of the Corporation.

     5.   Assignment; Binding Effect.  No Designating Party may assign its or
          --------------------------
their rights hereunder.  Subject to termination or partial termination as
provided in Section 1, this Agreement shall be binding on the parties hereto and
their respective legal representatives, successors and permitted assigns and on
the transferees of any Shares now owned or hereafter acquired by them.

     6.   Entire Agreement; Amendment and Waiver.  This Agreement contains the
          --------------------------------------
sole and entire understanding of the parties with respect to its subject matter
and supersedes all prior negotiations, commitments, agreements and
understandings heretofore had among any of them with respect thereto.  Without
limiting the generality of the foregoing, this Agreement supersedes and replaces
the Voting Agreement among the Corporation, the Founders, the Original Investors
and the Series B Investors dated as of December 22, 1995, which shall no longer
have any force or effect.  This Agreement may not be changed or terminated or
any performance or condition waived, in whole or in part, except by the written
agreement of the Corporation and Stockholders or transferees of their rights
hereunder holding two-thirds in voting power of the Shares held by the Founders,
two-thirds in voting power of the Shares held by the Original Investors, eighty-
five percent (85%) in voting power of the Shares held by the Series B Investors,
and two-thirds in voting power of the Shares held by the Investors.  A waiver on
one occasion shall not constitute a waiver on any further occasion.

     7.   Counterpart.  This Agreement may be executed in more than one
          -----------
counterpart, each of which shall be deemed to be an original and which,
together, shall constitute one and the same instrument.  Any such counterpart
may contain one or more signature pages.

     8.   Applicable Law.  This Agreement shall be governed by, and construed
          --------------
and enforced in accordance with, the substantive laws of The Commonwealth of
Massachusetts, without regard to its principles of conflicts of laws.

     9.   Legend. Each certificate for Shares shall bear a legend stating in
          ------
substance as follows, and each of the Stockholders shall cause its certificates
to be so legended promptly after the execution and delivery of this Agreement:

     The shares of stock represented by this certificate are subject to the
     terms and provisions of a Voting Agreement among the Corporation and
     certain stockholders of the Corporation.  The Corporation will furnish a
     copy of the Voting Agreement to the holder hereof upon written request and
     without charge.

                                     * * *

                                       4
<PAGE>

     IN WITNESS WHEREOF, the parties have executed this Voting Agreement as a
contract under seal as of the date first written above.

                                    SEQUENOM, INC.

                                    By:
                                       ---------------------------------
                                           its President


               FOUNDERS:
                                    ------------------------------------
                                    Hubert Koster

                                    ------------------------------------
                                    Nola E. Masterson

                                    ------------------------------------
                                    Robert E. Patterson


               ORIGINAL INVESTORS:

                                    TVM TECHNO VENTURE
                                    ENTERPRISES NO.  II
                                    LIMITED PARTNERSHIP

                                    By:  TVM Techno Venture Management
                                         Limited Partnership
                                         its General Partner
                                    By:  TVM Management Corporation
                                         its General Partner

                                    By:
                                       ---------------------------------
                                         Name:
                                         Title:
<PAGE>

                                    TVM INTERTECH LIMITED
                                    PARTNERSHIP

                                    By:  TVM Techno Venture Management
                                         Limited Partnership
                                          its General Partner
                                    By:  TVM Management Corporation
                                          its General Partner

                                    By:
                                         -------------------------------
                                         Its:

                                    TVM ZWEITE BETEILIGUNG-US
                                    LIMITED PARTNERSHIP

                                    By:  TVM Techno Venture Management
                                         Limited Partnership
                                          its General Partner
                                    By:  TVM Management Corporation
                                          its General Partner


                                    By:
                                         -------------------------------
                                         Its:
<PAGE>

                                    TVM EUROTECH LIMITED
                                    PARTNERSHIP

                                    By:  TVM Techno Venture Management
                                         Limited Partnership
                                          its General Partner
                                    By:  TVM Management Corporation
                                          its General Partner


                                    By:  -------------------------------
                                         Its:


                                    TVM TECHNO VENTURE
                                    INVESTORS NO. 1 LIMITED
                                    PARTNERSHIP


                                    By:
                                         -------------------------------
                                         General Partner


                                    ***

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                    SERIES B INVESTORS:

                                    TVM TECHNO VENTURE ENTERPRISES NO. II
                                    LIMITED PARTNERSHIP

                                    By:  TVM Techno Venture Management
                                         Limited Partnership
                                         its General Partner
                                    By:  TVM Management Corporation
                                         its General Partner

                                    By:    /s/ illegible
                                         ------------------------------
                                         Its:



                                    TVM INTERTECH LIMITED PARTNERSHIP

                                    By:  TVM Techno Venture Management
                                         Limited Partnership
                                    By:  TVM Management Corporation
                                         its General Partner


                                    By:    /s/ illegible
                                         ------------------------------
                                         Its:
<PAGE>

                                    TVM ZWEITE BETEILIGUNG-US
                                    LIMITED PARTNERSHIP

                                    By:  TVM Techno Venture Management
                                         Limited Partnership
                                         its General Partner
                                    By:  TVM Management Corporation
                                         its General Partner


                                    By:
                                         -------------------------------
                                         Its:

                                    TVM EUROTECH LIMITED PARTNERSHIP

                                    By:  TVM Techno Venture Management
                                         Limited Partnership
                                         its General Partner
                                    By:  TVM Management Corporation
                                         its General Partner


                                    By:
                                         -------------------------------
                                         Its:

                                    TVM TECHNO VENTURE
                                    INVESTORS NO. 1 LIMITED PARTNERSHIP


                                    By:
                                         -------------------------------
                                         General Partner
<PAGE>

                                    ***

                                    ALPINVEST INTERNATIONAL B. V.

                                    By:
                                       ---------------------------------
                                         Its:


                                    ***

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                    ------------------------------------
                                    Hubert Koster

                                    ------------------------------------
                                    Ernst-Gunter Afting

                                    ***

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

                               Voting Agreement

                            Investor Signature Page
                            -----------------------

     By executing this page in the space provided, the undersigned hereby agrees
(i) that it is an "Investor" and a "Stockholder" as defined in the Voting
Agreement dated as of May __, 1997, by and among Sequenom, Inc. and the parties
named therein, (ii) that it is a party to the Voting Agreement for all purposes
and (iii) that it is bound by all terms and conditions of the Voting Agreement.

     EXECUTED this ___ day of May, 1997.


                                    -----------------------------------
                                    (print name)


                                    By:
                                       --------------------------------

                                    Title:
                                          -----------------------------

                                    Address:
                                            ---------------------------

                                    -----------------------------------

                                    -----------------------------------
<PAGE>

                                                                       Exhibit A
                                                                       ---------
                                SEQUENOM, INC.
                               Voting Agreement

                      Additional Investor Signature Page
                      ----------------------------------

     By executing this page in the space provided, the undersigned hereby agrees
(i) that it is an "Additional Investor" as defined in the Series C Convertible
Preferred Stock Purchase Agreement dated as of May ___, 1997, and an "Investor"
and a "Stockholder" as defined in the Voting Agreement dated as of May ___,
1997, each by and among Sequenom, Inc. and the parties named therein, (ii) that
it is a party to the Voting Agreement for all purposes and (iii) that it is
bound by all terms and conditions of the Voting Agreement.

     EXECUTED this __ day of  ____________, 1997.


                                    ------------------------------------
                                    (print name)

                                    By:
                                       ---------------------------------

                                    Title:
                                          ------------------------------

                                    Address:
                                            ----------------------------
<PAGE>

                                 EXHIBIT 4.16C
                                 -------------


                      Form of Stock Restriction Agreement
                      -----------------------------------
<PAGE>

                          STOCK RESTRICTION AGREEMENT

     This Stock Restriction Agreement made as of May ___, 1997 by and among
Sequenom, Inc., a Delaware corporation (the "Corporation"); Hubert Koster
("Koster"), Nola E. Masterson ("Masterson") and Robert E. Patterson
("Patterson," and together with Koster and Masterson, the "Founders"); the
holders (the "Series B Investors") of shares of the Corporation's Series B
Convertible Preferred Stock, $.001 par value per share (the "Series B Preferred
Stock"); and the purchasers of shares of the Corporation's Series C Convertible
Preferred Stock, par value $.001 per share ("Series C Preferred Stock"),
pursuant to the Series C Convertible Preferred Stock Purchase Agreement dated as
of the date hereof (the "Purchase Agreement"), including any Additional
Investors as defined in the Purchase Agreement (such purchasers being
hereinafter referred to as the "Series C Investors", and, together with the
Series B Investors, the "Investors").

                                WITNESSETH THAT

     WHEREAS, the Series C Investors wish to purchase from the Corporation
certain shares of Series C Preferred Stock and certain warrants to purchase
shares of Series C Preferred Stock;

     WHEREAS, the Series C Investors' purchase of such Series C Preferred Stock
and warrants would materially benefit the Founders and the Series B Investors as
holders of certain shares of the Corporation's capital stock and rights to
acquire such capital stock;

     WHEREAS, it is a condition to the obligations of the Series C Investors
under the Purchase Agreement that this Agreement be executed by the Corporation,
the Founders and the Series B Investors, and the Corporation, the Founders and
the Series B Investors are willing to execute this Agreement and to be bound by
the provisions hereof;

     NOW, THEREFORE, in consideration of the foregoing, the agreements set forth
below, and the parties' desire to provide for continuity of ownership of the
Corporation to further the interests of the Corporation and its present and
future stockholders, the parties hereby agree with each other as follows:

     1.   Certain Defined Terms. As used in this Agreement, the following terms
          ---------------------
shall have the following respective meanings:

     (a) "Common Stock" means the Corporation's Common Stock, $.001 par value
per share.

     (b) "Convertible Securities" means any evidences of indebtedness, shares of
capital stock or other securities directly or indirectly convertible into or
exchangeable for Common Stock.

     (c) "Options" means any rights, options, or warrants to subscribe for,
purchase or otherwise acquire Common Stock or Convertible Securities.

     (d) "Series A Preferred Stock" means the Corporation's Series A Convertible
Preferred Stock, $.001 par value per share.
<PAGE>

     (e) "Shares" shall mean and include all shares of Stock now owned or
hereafter acquired by any Founder or any Investor.

     (f) "Stock" shall mean and include all shares of Common Stock, all
Convertible Securities, all Options, and all other securities of the Corporation
which may be issued in exchange for or in respect of shares of Common Stock,
Convertible Securities or Options (whether by way of stock split, stock
dividend, combination of shares, reclassification, recapitalization,
reorganization, or any other means).

     2.   Prohibited Transfers. None of the Founders shall sell or otherwise
          --------------------
transfer, by gift or otherwise, all or any part of his Shares except in
compliance with the terms of this Agreement.

     3.   Offer of Sale; Notice of Proposed Sale or Transfer. If any Founder
          --------------------------------------------------
desires to sell or otherwise transfer any of his Shares, or of any interest
therein, whether voluntarily or by operation of law, in any transaction other
than pursuant to clauses (iii) or (iv) of Section 7(a) of this Agreement, such
Founder (the "Selling Founder") shall first deliver written notice of his desire
to do so (the "Notice") to the Corporation and each of the Investors. The Notice
must specify: (i) the name and address of the party to which the Selling Founder
proposes to sell or otherwise transfer the Shares or an interest in the Shares
(the "Proposed Transferee"), (ii) the number of Shares the Selling Founder
proposes to sell or otherwise transfer (the "Offered Shares"), (iii) the
consideration per Share to be delivered to the Selling Founder for the proposed
sale or transfer, and (iv) all other material terms and conditions of the
proposed transaction, which must be bona fide.

     4.   Corporation's Option to Purchase.
          --------------------------------

     (a) Except as set forth in Section 7(a), the Corporation shall have the
first option to purchase all or any part of the Offered Shares for the
consideration per Share and on the terms and conditions specified in the Notice.
The Corporation must exercise such option, no later than fifteen (15) business
days after such Notice is deemed to have been delivered to it, by written notice
to the Selling Founder.

     (b) In the event the Corporation does not exercise its option within such
fifteen-business-day period with respect to all of the Offered Shares, the Chief
Financial Officer of the Corporation shall, by the last day of such period, give
written notice of that fact to the Investors (the "Investor Notice").  The
Investor Notice shall specify the number of Offered Shares the Corporation has
elected not to purchase (the "Remaining Shares").

     (c) In the event the Corporation duly exercises its option to purchase all
or a portion of the Offered Shares, the closing of such purchase shall take
place at the offices of the Corporation on the later of (i) the date five
business days after the expiration of such fifteen-business-day period or (ii)
the date that the Investors consummate their purchase of Offered Shares under
Section 5(c) hereof.

     (d) To the extent that the consideration proposed to be paid by the
Proposed Transferee for the Offered Shares consists of property other than cash
or a promissory note, the consideration required to be paid by the Corporation
and/or the Investors exercising their options

                                       2
<PAGE>

under Sections 4 and 5 hereof, respectively, may consist of cash equal to the
value of such property, as determined in good faith by agreement of the Selling
Founder and the Corporation and/or the Investors acquiring such Offered Shares.

     5.   Investors' Option to Purchase and Right to Participate in Sales.
          ---------------------------------------------------------------

          (a) Except as set forth in Section 7(a), each Investor shall have an
option, exercisable for a period of fifteen (15) business days from the date of
delivery of the Investor Notice, to purchase, on a pro rata basis, its
Proportionate Percentage (as defined below) of the Remaining Shares, for the
consideration per Share and on the terms and conditions set forth in the Notice.
Such option shall be exercised by delivery of written notice to the Chief
Financial Officer of the Corporation.  Alternatively, each Investor may, within
the same fifteen-business-day period, notify the Chief Financial Officer of the
Corporation of its desire to participate in the sale of Shares and to sell, on
the terms as set forth in the Notice including at the same price per Share on a
common equivalent basis, up to an equivalent proportion of the Series B
Preferred Stock and Series C Preferred Stock owned by such Investor as the
proposed sale of the Remaining Shares represents with respect to the Shares then
owned by the Selling Founder.

          (b) In the event options to purchase have been exercised by the
Investors with respect to some but not all of the Remaining Shares, the Chief
Financial Officer of the Corporation shall promptly give written notice of that
fact to those Investors who have exercised their options within such period (the
"Second Investor Notice").  The Second Investor Notice shall specify the number
of Remaining Shares the Investors have not elected to purchase.  The Investors
who have exercised their options within the fifteen-business-day period
specified in Section 5(a) shall have an additional option, for a period of ten
(10) business days after delivery of the Second Investor Notice, to purchase all
or any part of the balance of such Remaining Shares on the terms and conditions
set forth in the Notice, which option shall be exercised by the delivery of
written notice to the Chief Financial Officer of the Corporation.  In the event
that there are two or more such Investors that choose to exercise the last-
mentioned option for a total number of Remaining Shares in excess of the number
available, the Remaining Shares available for each such Investor's option shall
be allocated to such Investors pro rata based on their respective Proportionate
Percentages (as defined below).

          (c) Promptly after the expiration of the last period for exercise of
an Investor's purchase option, the Chief Financial Officer of the Corporation
shall give written notice to the Selling Founder and the purchasing Investors,
specifying the number of Remaining Shares to be purchased by each purchasing
Investor.  The closing of the purchase of the Remaining Shares shall take place
at the offices of the Corporation no later than five (5) business days after
delivery of such notice to the Selling Founder and the purchasing Investors.

          (d) As used in this Section 5, the term "Proportionate Percentage"
shall mean with respect to each Investor a fraction, the numerator of which
shall be the amount of Series B Preferred Stock and Series C Preferred Stock
owned by such Investor, and the denominator of which shall be the total amount
of Series B Preferred Stock and Series C Preferred Stock owned by all Investors,
in each case on a common equivalent basis.

                                       3
<PAGE>

     6.   Co-Sale.
          -------

          (a) If the Corporation and the Investors do not exercise their options
to purchase all of the Offered Shares within the periods described in this
Agreement (the "Option Period"), then each Investor which has, pursuant to
Section 5(a), expressed a desire to sell shares of Series B Preferred Stock and
Series C Preferred Stock in the transaction (a "Participating Investor") shall
be entitled to do so pursuant to this Section.  The Chief Financial Officer of
the Corporation shall promptly, on expiration of the Option Period, notify the
Selling Founder of the aggregate amount of Series B Preferred Stock and Series C
Preferred Stock the Participating Investors wish to sell.  The Selling Founder
shall use his best efforts to interest the Proposed Transferee in purchasing, in
addition to the Remaining Shares not subscribed for by the Investors, the Series
B Preferred Stock and Series C Preferred Stock the Participating Investors wish
to sell.  If the Proposed Transferee does not wish to purchase all of the Stock
so made available by the Selling Founder and the Participating Investors, then
each Participating Investor and the Selling Founder shall be entitled to sell,
on the terms and conditions set forth in the Notice and on the same price per
share on a common equivalent basis, a portion of the Stock being sold to the
Proposed Transferee, in the same proportion as such Selling Founder or
Participating Investor's ownership of Stock on a common equivalent basis bears
to the aggregate amount of Stock owned by the Selling Founder and the
Participating Investors on a common equivalent basis.  The transaction
contemplated by the Notice shall be consummated not later than 60 days after the
expiration of the Option Period.

          (b) If the Participating Investors do not elect to sell the full
amount of Series B Preferred Stock and Series C Preferred Stock which they are
entitled to sell pursuant to Section 6(a), the Selling Founder shall be entitled
to sell to the Proposed Transferee, according to the terms set forth in the
Notice, that number of his Shares which equals the difference between the amount
of Stock desired to be purchased by the Proposed Transferee and the number of
shares of Series B Preferred Stock and Series C Preferred Stock the
Participating Investors wish to sell, in each case on a common equivalent basis.

          (c) If the Selling Founder wishes to sell or otherwise transfer any of
his Shares at a price per Share which differs from that set forth in the Notice,
upon terms different from those previously offered to the Corporation and the
Investors, or more than 60 days after the expiration of the Option Period, then,
as a condition precedent to such transaction, such Shares must first be offered
to the Corporation and the Investors on the same terms and conditions as given
the Proposed Transferee, and the Investors must first be offered the opportunity
to participate in such transaction, in accordance with the procedures and time
periods set forth above.

     7.   Permitted Transfers.
          -------------------

          (a) Subject to the provisions of Section 7(b) and Section 8, the
Corporation's and the Investors' right of first refusal and the Investors' right
of co-sale described in Sections 4 through 6 shall not apply to: (i) any
transfer of Shares by a Founder by gift or bequest or through inheritance to, or
for the benefit of, any member or members of such Founder's immediate family;
(ii) any transfer of Shares by an Founder to a trust (A) in respect of which
such Founder serves as trustee, provided that the trust instrument governing
such trust shall provide that such

                                       4
<PAGE>

Founder, as trustee, shall retain sole and exclusive control over the voting and
disposition of such Shares until the termination of this Agreement or (B) for
the benefit solely of any member or members of such Founder's immediate family;
(iii) any sale or transfer of Shares to the Corporation; (iv) any underwritten
public offering of Common Stock pursuant to an effective registration statement
under the Securities Act of 1933, as amended (the "Securities Act"); and (v)
with respect to sales or other transfers of up to an aggregate of the following
number of Shares (as adjusted to reflect any stock split, stock dividend,
combination of shares or other similar transaction), but subject in any case to
the restrictions set forth in Section 8: (A) in the case of each of Koster and
Masterson, 130,000 Shares; and (B) in the case of Patterson, 50,000 Shares;

          (b) In the event of any sale or transfer described in clauses (i) or
(ii) of Section 7(a), the transferee of the Shares shall hold the Shares so
acquired subject to all the restrictions imposed by this Agreement and shall be
deemed a Founder for all purposes hereof, and as a condition to such transfer,
any such transferee shall, at the request of the Corporation or any Investor,
execute and deliver a written instrument agreeing to be bound by the provisions
of this Agreement.

     8.   Consent of the Corporation to Transfer. As a condition to selling or
          --------------------------------------
otherwise transferring any Shares proposed to be sold or transferred by the
Selling Founder and any Participating Investor to any Proposed Transferee, other
than a sale or transfer described in clause (iii) or (iv) of Section 7(a), the
Selling Founder shall have obtained the written consent to such transfer by the
Board of Directors of the Corporation by majority vote at a meeting or by
unanimous consent in lieu of a meeting. Such consent shall not be unreasonably
withheld, and shall be based on the Board of Directors' determination, after
such inquiry as it deems appropriate, but within thirty days of the date of the
Selling Founder's notice to the Corporation under Section 3, that the Proposed
Transferee is not a competitor of the Corporation and is not otherwise an
inappropriate investor in the Corporation. In the event the Selling Founder
disagrees with such determination, and the Board of Directors and the Selling
Founder are unable to resolve the disagreement, an independent third party
selected and agreed upon by the Board of Directors and the Selling Founder shall
arbitrate and finally resolve the disagreement.

     9.   Lock-up. Each Founder agrees that upon the request of the Corporation
          -------
or the underwriters managing an underwritten offering of the Corporation's
securities, such Founder will not sell, make any short sale or loan of, grant
any option for the purchase of, or otherwise dispose of any Shares held by him
without the prior written consent of the Corporation or such underwriters, as
the case may be, for a period of up to 180 days from effective date of the
applicable registration statement.

     10.  Sale or Transfer in Violation of this Agreement. If any sale or other
          -----------------------------------------------
transfer of Shares is made or attempted in violation of any provision of this
Agreement, or if any Shares are not offered to the Corporation or the Investors
as required hereby, the Corporation and the Investors, as the case may be, shall
have the right to purchase such Shares from the owner thereof or his transferee
at any time before or after the transfer, as herein provided. In addition to any
other legal or equitable remedies which it or they may have, the Corporation and
the Investors may enforce their respective rights hereunder by actions for
specific performance (to the extent permitted by law). The Corporation shall not
be required (i) to transfer on its books

                                       5
<PAGE>

any Shares or other Stock which has been sold or transferred in violation of any
provision of this Agreement or (ii) to treat as the owner of such Shares or
Stock, or to pay dividends to, any transferee to whom any such Shares or Stock
have been so sold or transferred. If a Founder becomes obligated to sell any
Shares to the Corporation under this Agreement and fails to deliver such Shares
in accordance with the terms of this Agreement, the Corporation may, at its
option, in addition to all other remedies it may have, send to such Founder the
purchase price for such Shares as is herein specified and cancel on its books
the certificate or certificates representing the Shares to be sold. Thereafter,
all of the Founder's rights in and to such Shares shall terminate.

     11.  Disposition of Shares. Any Shares that the Corporation elects to
          ---------------------
purchase hereunder may be disposed of by it in such manner as it deems
appropriate with or without restrictions on the transfer thereof, and the
Corporation may require their transfer to a nominee or designee as part of any
purchase of the Shares from the Founders.

     12.  Restrictive Legend. All certificates representing Shares held by the
          ------------------
Founders which are subject to this Agreement shall have affixed thereto a legend
in substantially the following form, in addition to any other legends that may
be required by the Corporation in connection with compliance with federal or
state securities laws or otherwise:

          "The shares of stock represented by this certificate are subject to
          restrictions on transfer and/or an option to purchase set forth in a
          Stock Restriction Agreement between the Corporation and the registered
          owner of the shares represented by this certificate (or his
          predecessor in interest).  The Corporation will furnish a copy of such
          agreement to the holder of this certificate upon written request
          without charge."

The Founders shall cause such legend to be affixed to any of such certificates
not so legended.

     13.  Term. This Agreement shall terminate upon the closing of a fm
          ----
commitment underwritten public offering of Common Stock pursuant to an effective
registration statement under the Securities Act in which (i) the public offering
price per share is not less than $9.45 (appropriately adjusted to take account
of any stock split, stock dividend, combination of shares or similar event) and
(ii) the aggregate gross proceeds to the Corporation are not less than
$20,000,000.

     14.  Specific Enforcement. Each Founder expressly agrees that a violation
          --------------------
of this Agreement by such Founder could not be adequately compensated by money
damages alone and that the Investors and the Corporation will be irreparably
damaged if this Agreement is not specifically enforced. Upon a breach or
threatened breach of the terms, covenants and/or conditions of this Agreement by
any Founder, the Investors and the Corporation shall, in addition to all other
remedies, each be entitled to a temporary or permanent injunction, and/or a
decree for specific performance, in accordance with the provisions hereof.

     15.  Other Agreements. The restrictions on the Founders' right to dispose
          ----------------
of their Shares pursuant to this Agreement are in addition to and to be
construed consistently with the Founders' rights and obligations (including
restrictions on the Founders' right to dispose of

                                       6
<PAGE>

shares of the Corporation's capital stock) contained in any other agreement
relating to restrictions on the transferability of such Shares that the Founders
execute before, on, or after the date hereof; provided, that this Agreement
shall supersede and replace the Stock Restriction Agreement dated as of December
22, 1995 among the Corporation, the Founders and the Series B Investors, which
shall no longer be of any force or effect.

     16.  Waiver, Modification and Termination. No provision of this Agreement
          ------------------------------------
shall be deemed to have been waived by the Corporation or any Investor in the
absence of a written agreement executed by such party with respect to such
waiver. This Agreement may be modified or terminated only with the written
consent of the Founders, the Corporation, and the holders of a majority in
voting power of the Shares then held by the Investors.

     17.  Accession. Any Additional Investors as defined in the Purchase
          ---------
Agreement shall automatically become an Investor hereunder by delivering to the
Corporation a written instrument in the form of Exhibit A hereto, by which such
                                                ---------
Additional Investor agrees to be bound by the obligations imposed under this
Agreement, whereupon such Additional Investor shall automatically become a party
to this Agreement and shall thereupon be deemed an "Investor" for all purposes
of this Agreement.

     18.  Binding Effect; Assignment. This Agreement shall be binding upon the
          --------------------------
parties hereto and their heirs, legal representatives, successors and assigns.
The rights and obligations of the Founders hereunder may not be assigned or
delegated without the written consent of the Corporation.

     19.  Notices. All notices, requests, consents, deliveries and other
          -------
communications hereunder shall be in writing and shall be delivered in person or
duly sent by first class mail postage prepaid (other than in the case of non-
U.S. parties) or by fax or DHL, Federal Express or other internationally
recognized express courier service, to the Corporation at its principal place of
business, and to the Investors and the Founders at their respective last known
address or at their respective address, if any, appearing on the books of the
Corporation.

     20.  Severability. If any provision of this Agreement shall be held to be
          ------------
illegal, invalid or unenforceable, such illegality, invalidity or
unenforceability shall attach only to such provision and shall not in any manner
affect or render illegal, invalid or unenforceable any other provision of this
Agreement, and this Agreement shall be carried out as if any such illegal,
invalid or unenforceable provision were not contained herein.

     21.  Governing Law. This Agreement shall be governed by, and construed and
          -------------
enforced in accordance with, the substantive law of The Commonwealth of
Massachusetts, without regard to its principles of conflicts of laws.

     22.  Captions. Captions are for convenience only and are not deemed to be
          --------
part of this Agreement.

     23.  Counterparts. This Agreement may be executed in one or more
          ------------
counterparts, each of which shall be deemed an original and all of which
together she constitute a single instrument. Each such counterpart may contain
one or more signature pages.

                                       7
<PAGE>

     IN WITNESS WHEREOF, the parties hereto have executed this Stock Restriction
Agreement as a contract under seal as of the day and year first above written.

                                    SEQUENOM, INC.

                                    By: _____________________________
                                         Its President

          FOUNDERS:


                                    _________________________________
                                    Hubert Koster


                                    _________________________________
                                    Nola E. Masterson


                                    _________________________________
                                    Robert E. Patterson

          SERIES B INVESTORS:
                                    TVM TECHNO VENTURE
                                    ENTERPRISES NO. II
                                    LIMITED PARTNERSHIP

                                    By:  TVM Techno Venture Management
                                         Limited Partnership
                                          its General Partner

                                    By:  TVM Management Corporation
                                          its General Partner

                                    By: _____________________________
                                         Name:
                                         Title:
<PAGE>

                              TVM INTERTECH LIMITED
                              PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                     its General Partner

                              By:   TVM Management Corporation
                                     its General Partner

                              By: _________________________________
                                  Its:

                              TVM ZWEITE BETEILIGUNG-US
                              LIMITED PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                     its General Partner

                              By:   TVM Management Corporation
                                     its General Partner

                              By: _________________________________
                                  Its:
<PAGE>

                              TVM EUROTECH LIMITED
                              PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                     its General Partner

                              By:   TVM Management Corporation
                                     its General Partner

                              By: _________________________________
                                  Its:

                              TVM TECHNO VENTURE
                              INVESTORS NO. 1 LIMITED
                              PARTNERSHIP


                              By: _________________________________
                                  General Partner


                              ***

                              ALPINVEST INTERNATIONAL B.V.


                              By: _________________________________
                                  Its:

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                              ***

                              _____________________________________
                              Hubert Koster


                              _____________________________________
                              Ernst-Gunter Afting

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                              ***

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                SEQUENOM, INC.

                          Stock Restriction Agreement

                        Series C Investor Signature Page
                        --------------------------------

     By executing this page in the space provided, the undersigned hereby agrees
(i) that it is a "Series C Investor" as defined in the Stock Restriction
Agreement dated as of May __, 1997, by and among Sequenom, Inc. and the parties
named therein, (ii) that it is a party to the Stock Restriction Agreement for
all purposes and (iii) that it is bound by all terms and conditions of the Stock
Restriction Agreement.


EXECUTED this ___ day of May, 1997.


                                  _____________________________________
                                  (print name)


                                  By: _________________________________

                                  Title:_______________________________

                                  Address:_____________________________

                                  _____________________________________

                                  _____________________________________

                                  _____________________________________
<PAGE>

                                   Exhibit-A
                                   ---------

                                 SEQUENOM, INC.

                          Stock Restriction Agreement

                       Additional Investor Signature Page
                       ----------------------------------

     By executing this page in the space provided, the undersigned hereby agrees
(i) that it is an "Additional Investor" as defined in the Series C Convertible
Preferred Stock Purchase Agreement dated as of May __, 1997 and an "Investor" as
defined in the Stock Restriction Agreement dated as of May __, 1997 each by and
among Sequenom, Inc. and the parties named therein, (ii) that it is a party to
the Stock Restriction Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Stock Restriction Agreement.

     EXECUTED this ___ day of ______________, 1997.


                              -----------------------------------------------
                              (print name)

                              By:
                                 --------------------------------------------
                              Title:
                                    -----------------------------------------
                              Address:
                                      ---------------------------------------
<PAGE>

                                  EXHIBIT 4.19
                                  ------------


                              Related Transactions
                              --------------------


None.
<PAGE>

                                  EXHIBIT 4.20
                                  ------------


                             Governmental Consents
                             ---------------------


None.
<PAGE>

                                  EXHIBIT 4.23
                                  ------------



                       Commitments from German Government
                       ----------------------------------


Sequenom, Inc. (the "Inc.") and Sequenom Instruments GmbH (the "GmbH")

Description of agreements with Technnologie-Beteiligungs-Gesellischaft m.b.H.
der Deutschen Ausgleichsbank ("TBG")


1.   The May 1995 "BJTU" Agreement
     -----------------------------

The TBG has provided DM 1 million silent partnership financing to the GmbH,
which matches DM 1 million of capital invested in the GmbH by the Inc.  The
terms of the silent partnership arrangement are as follows:

Interest rate of 6% on the principal amount of the silent partnership loan.

Interest payable beginning June 30, 1997.

Additional compensation as follows:
9% of any annual profits, beginning with fiscal year 1997, if the profits exceed
DM 100,000, up to a maximum compensation amount of 6% of the silent partnership
loan

Principal payment due on December 31, 2005

This agreement has no "downside protection," which is contained in the 1995
agreement.

2.   The December 1995 "BJTU." Agreement
     -----------------------------------

The TBG has committed to provide up to DM 3 million silent partnership financing
to the GmbH, which will match up to DM 3 million of capital invested in the GmbH
by the Inc.  The TBG has matched the entire DM 3 million of capital which has
been invested by the Inc.

The terms of the silent partnership arrangement are as follows:


Interest rate of 6% on the principal amount of the silent partnership loan.

Interest payable beginning June 30, 1997.
<PAGE>

                 Commitments from German Government, continued



Additional compensation as follows:
9% of any annual profits, beginning with fiscal year 1997, if the profits exceed
DM 100,000, up to a maximum compensation amount of 6% of the silent partnership
loan

Principal payment due on December 31, 2005

This agreement also contains a "50% downside protection" for the investors in
the Inc. as follows: Under certain circumstances, if the Inc. exercises its "put
option" to the TBG of its equity interest in the GmbH, the TBG will pay to the
Inc. 50% of the amount of the silent partnership.


Description of the grant programs for which Sequenom Instruments GmbH has
received approvals:

1.   Grant from the "Biotechnology 2000" grant scheme from the Ministry of
Research and Technology ("BMBF"):

     The BMBF has approved a grant (which is a non-repayable contribution) in
the amount of DM 2.2 million based on the application for the financing of a
total research and development project of DM 4.4 million.  The grant coverage is
therefore 50% of total estimated project cost.  The company will call the money
quarterly in arrears based on actual cost attributable to the project.  The
project started on September 1, 1995 and has a duration of three years.

2.   Grant from Freie und Hansestadt Hamburg (City of Hamburg):

     The City of Hamburg has approved a grant of DM 800,000 based on a list of
equipment for Sequenom's laboratory to be purchased after September 1, 1995.
Total expected cash outflows for the equipment purchases is DM 1.6 million.
Grant coverage is also 50% of estimated cost.

Both grants do not have to be repaid.
<PAGE>

                                  EXHIBIT 6.5
                                  -----------


                   Form of Opinion of Counsel to Corporation
                   -----------------------------------------
<PAGE>

                            FOLEY, HOAG & ELIOT LLP
                             ONE POST OFFICE SQUARE
                        BOSTON, MASSACHUSETTS 02109-2170
                           TELEPHONE: (617) 832-1000
                            FACSIMILE (617) 832-7000
                                  TELEX 940593
                               http://www.fhe.com
                                                             IN WASHINGTON. D.C.
                                                             1615 L STREET, N.W.
                                                                       SUITE 860
                                                           WASHINGTON D.C. 20036
                                                      TELEPHONE:  (202) 776-0600

                                    May 8, 1997

To the Persons listed in the Schedule of
 Investors to the Series C Convertible
 Preferred Stock Purchase Agreement
 dated as of May 8, 1997

Ladies/Gentlemen:

     We are counsel to Sequenom, Inc., a Delaware corporation (the
"Corporation").  This opinion is rendered to you pursuant to Section 6.5 of the
Series C Convertible Preferred Stock Purchase Agreement (including the exhibits
thereto, the "Agreement') dated as of May 8, 1997, among the Corporation and
each of you relating to the issuance and sale by the Corporation to you of up to
an aggregate of 1,904,770 shares (the "Shares") of its Series C Convertible
Preferred Stock, par value $.001 per share ("Series C Preferred"), and warrants
to purchase up to an aggregate of 190,477 shares of Series C Preferred (the
"Warrants") (the "Transaction").  Capitalized terms used herein and not
otherwise defined herein shall have the meanings assigned to such terms in the
Agreement.

     In connection with our rendering this opinion, we have reviewed (i) the
Certificate of Incorporation and By-Laws of the Corporation, each as amended to
date; (ii) a certificate issued by the Secretary of State of the State of
Delaware on May 2, 1997, with respect to the due incorporation, legal existence
and good standing of the Corporation in the State of Delaware (the "Legal
Existence Certificate"); (iii) counterparts of the Agreement and the related
Registration Rights Agreement dated May 8, 1997 (the "Registration Rights
Agreement'); and (iv) originals or copies, certified or otherwise, identified to
our satisfaction, of such other documents, certificates, instruments and
corporate records that we considered necessary for the purposes of this opinion.

     In rendering the opinion expressed herein, we have also examined and have
relied completely as to matters of fact upon the representations and warranties
made by the Corporation and each of you in the Agreement, the Registration
Rights Agreement and the other agreements, instruments and documents delivered
in connection with the Initial Closing on the date hereof; and we have assumed
the completeness and accuracy of all factual matters described in such
representations and warranties.
<PAGE>

To the Persons listed in the Schedule of
 Investors to the Series C Convertible
 Preferred Stock Purchase Agreement
 dated as of May 8, 1997


     We have not, except as specifically noted above, made any independent
review or investigation of facts relating to the Corporation, including but
without limiting the generality of the foregoing, any investigation as to the
existence of any actions, suits or proceedings pending or threatened against the
Corporation or notes, indentures, mortgages, leases, contracts, instruments,
documents, agreements, judgments, injunctions, orders, writs or decrees to which
the Corporation is a party, which are binding upon the Corporation or which
might result in the imposition of any lien or other encumbrance on any asset of
the Corporation.

     We have assumed the authenticity and completeness of all documents
furnished to us as originals, the genuineness of all signatures, the legal
capacity of natural persons, and the conformity to the originals of all
documents furnished to us as copies.

     In rendering the opinions expressed in paragraph 1 below with respect to
the due incorporation, legal existence and good standing of the Corporation in
Delaware, we have relied solely on the Legal Existence Certificate.

     You have not asked us to pass upon your power and authority to enter into
the Agreement or the Registration Rights Agreement.  Accordingly, for the
purposes of this opinion, we have assumed that you have all requisite power and
authority to enter into the Agreement and the Registration Rights Agreement and
to effect the transactions contemplated thereby, and that each of the Agreement
and the Registration Rights Agreement constitutes the valid and legally binding
obligation of all parties thereto other than the Corporation.

     We have made such examination of Massachusetts and federal Law and of the
General Corporation Law of Delaware as we deem necessary for the purposes of
this opinion.  We do not purport to pass herein on the laws of any state or
jurisdiction other than the United States of America and the Commonwealth of
Massachusetts, and as to its General Corporation Law only, the State of
Delaware.

     The opinions herein expressed are qualified to the extent that (i) the
validity or enforceability of any provisions of any agreement or instrument or
of any rights granted thereunder may be subject to or affected by any
bankruptcy, reorganization, insolvency, moratorium or similar law from time to
time in effect and relating to or affecting the rights or remedies of creditors
generally, (ii) the remedy of specific performance or any other equitable remedy
may be unavailable in any jurisdiction or may be withheld as a matter of
judicial discretion; and (iii) a court may apply equitable principles in
construing or enforcing the provisions of any agreement or instrument.

     The phrase "of which we have knowledge" means the actual knowledge of the
lawyer signing this opinion letter and the other lawyers in our office who have
had active involvement in negotiating the Transaction and preparing the
Agreement and the Registration Rights Agreement.

     Based upon and subject to the foregoing, we are of the opinion that:

                                       2
<PAGE>

To the Persons listed in the Schedule of
 Investors to the Series C Convertible
 Preferred Stock Purchase Agreement
 dated as of May 8, 1997


     1.   The Corporation is a corporation duly incorporated, validly existing
          and in good standing under the laws of the State of Delaware and has
          the requisite corporate power to carry on its business as it is
          currently being conducted.

     2.   The execution and delivery of the Agreement and the Registration
          Rights Agreement and the performance by the Corporation of its
          obligations thereunder have been duly authorized by all necessary
          corporate action on the part of the Corporation and do not violate or
          cause any default under any provision of (i) the Corporation's
          Certificate of Incorporation or By-Laws, or (ii) except where any such
          violation or default would not have a material adverse effect on the
          Corporation, any note, indenture, mortgage, lease, contract or other
          instrument, document or agreement to which the Corporation is a party
          and of which we have knowledge or any writ, injunction, order,
          judgment or decree of any court, administrative agency or other
          governmental body to which the Company is a party and of which we have
          knowledge.  Each of the Agreement and the Registration Rights
          Agreement constitutes a valid and legally binding obligation of the
          Corporation, enforceable against the Corporation in accordance with
          its terms; provided, however, that we express no opinion as to the
          enforceability of the indemnification provisions contained in Section
          10 of the Registration Rights Agreement.

     3.   The sale of Shares and the Warrants to each of you is not required to
          be registered under the Securities Act of 1933 or the Massachusetts
          Uniform Securities Act.

     4.   Upon receipt by the Corporation of the purchase price therefor, the
          Shares will be validly issued, fully-paid and non-assessable.

     5.   No authorization, consent, approval or other order of, declaration to,
          or filing with, any United States or Massachusetts governmental agency
          or body is required to be made or obtained by the Corporation for or
          in connection with the valid and lawful authorization, execution and
          delivery by the Corporation of the Agreement and the Registration
          Rights Agreement, for or in connection with the valid and lawful
          authorization, issuance, sale and delivery of the Shares and the
          Warrants or for or in connection with the valid and lawful
          authorization, reservation, issuance, sale and delivery of the
          Reserved Shares to be issued upon the conversion of the Shares, except
          such exemptive filings, if any, as are required to be made under
          applicable securities laws.


                                    Very truly yours,

                                    FOLEY, HOAG & ELIOT LLP



                                    By:
                                       ----------------------------------------
                                           A Partner

                                       3

<PAGE>

                                                                   EXHIBIT 10.3

NEITHER THIS WARRANT NOR THE SHARES OF CAPITAL STOCK PURCHASABLE HEREUNDER HAVE
BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY STATE
SECURITIES LAW AND, ACCORDINGLY, NEITHER THIS WARRANT NOR SUCH SHARES MAY BE
OFFERED FOR SALE, SOLD, PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED UNLESS
THE REGISTRATION PROVISIONS OF SUCH ACT AND ALL APPLICABLE STATE SECURITIES LAWS
HAVE BEEN COMPLIED WITH OR UNLESS THE CORPORATION HAS RECEIVED AN OPINION OF
COUNSEL ACCEPTABLE TO IT THAT SUCH REGISTRATION IS NOT REQUIRED.

THE SHARES OF CAPITAL STOCK PURCHASABLE HEREUNDER ARE SUBJECT TO THE TERMS AND
PROVISIONS OF A VOTING AGREEMENT AMONG THE CORPORATION AND CERTAIN STOCKHOLDERS
OF THE CORPORATION.  THE CORPORATION SHALL FURNISH A COPY OF SUCH VOTING
AGREEMENT TO ANY REGISTERED HOLDER OF THIS WARRANT OR SUCH SHARES OF CAPITAL
STOCK UPON WRITTEN REQUEST AND WITHOUT CHARGE.


                                SEQUENOM, INC.

                            STOCK PURCHASE WARRANT

                      Warrant to Purchase _____ Shares of
                     Series C Convertible Preferred Stock

                          Issued to ________________

                            Void after May __, 2004


    Sequenom, Inc., a Delaware corporation (the "Corporation'), hereby
covenants and agrees with ____________ as follows:

1.  The Warrant.
    -----------

    1.01  For value received and subject to the terms and conditions
hereinafter set forth, the registered holder of this Warrant (the
"Warrantholder") is entitled upon its surrender, with the subscription form
annexed hereto duly executed, at the office of the Corporation at 11555 Sorrento
Valley Road, Suite C, San Diego, California 92121, or at such other office as
the Corporation shall notify the Warrantholder in writing, to purchase from the
Corporation __________ fully paid and non-assessable shares of the Series C
Convertible Preferred Stock, par value $.001 per share ("Series C Preferred
Stock"), of the Corporation for $3.15 per share (the "Exercise Price"), subject
to adjustment as set forth in Sections 2 and 4 hereof.  This Warrant may be
exercised in full or in part from time to time.  As promptly as practicable
after
<PAGE>

surrender of this Warrant and receipt of payment of the Exercise Price, the
Corporation shall issue and deliver to the Warrantholder a certificate or
certificates for shares of Series C Preferred Stock, in certificates of such
denominations and in such name as the Warrantholder may specify, together with
any other stock, securities or property that such holder may be entitled to
receive pursuant hereto. This Warrant shall expire at the close of business on
May 8, 2004, and shall be void thereafter. Upon and after the Automatic
Conversion Effective Time (as defined in Section 4), the right to purchase
Series C Preferred Stock granted herein shall terminate, and this Warrant shall
represent the right to purchase shares of the Common Stock, par value $.001 per
share, of the Corporation ("Common Stock") as provided in Section 4 hereof. The
shares of Series C Preferred Stock, Common Stock or securities or other property
purchasable upon exercise of this Warrant are sometimes referred to hereinafter
as "Warrant Shares".

    1.02  Prior to the Automatic Conversion Effective Time (as defined in
Section 4), the Corporation shall at all times have authorized and reserved for
purposes of issue upon exercise of the rights evidenced hereby, a sufficient
number of shares of its Series C Preferred Stock to provide for the exercise of
such rights, and shall at all times have authorized and reserved a sufficient
number of shares of its Common Stock for purposes of issue upon conversion of
such shares of Series C Preferred Stock under the terms of the Charter (as
defined in Subsection 2.05). From and after the Automatic Conversion Effective
Time, the Corporation shall at all times have authorized and reserved for
purposes of issue upon exercise of the rights evidenced hereby, a sufficient
number of shares of its Common Stock to provide for the exercise of such rights.
Upon surrender for exercise, this Warrant shall be cancelled and shall not be
reissued; provided, however, that upon the partial exercise hereof a substitute
Warrant of like tenor and date to the original Warrant representing the rights
to subscribe for and purchase any such unexercised portion hereof shall be
issued.

    1.03  This Warrant may be subdivided into one or more stock purchase
warrants entitling the Warrantholder to purchase Warrant Shares in multiples of
one or more whole shares, upon surrender of the Warrant by the Warrantholder for
such purpose at the office of the Corporation.

    1.04  The Corporation shall maintain at its office (or at such other office
or agency of the Corporation as it may from time to time designate in writing to
the Warrantholder), a register containing the names and address of the holder of
this Warrant.  The registered holder of this Warrant shall be the person in
whose name this Warrant is originally issued and registered, unless a subsequent
holder shall have presented to the Corporation the Warrant, duly assigned to
him, for inspection, and a written notice of his acquisition of the Warrant and
designating in writing the address of such holder, in which case such subsequent
holder of the Warrant shall become a subsequent registered holder, and a
Warrantholder as defined herein.  Any Warrantholder may change his address as
shown on such register by written notice to the Corporation requesting such
change.  Any written notice required or permitted to be given to any
Warrantholder shall be delivered in person or duly sent by first class mail
postage prepaid (other than to non-U.S. parties) or fax or DHL, Federal Express
or other internationally recognized express courier service, to such
Warrantholder at his address as shown on such register.

                                      -2-
<PAGE>

    1.05  If any shares of Common Stock issuable hereunder upon and after the
Corporation's initial public offering of Common Stock require listing on any
domestic securities exchange, before such shares may be issued upon exercise of
this Warrant, the Corporation shall, at its expense and as expeditiously as
possible, use its best efforts to cause such shares to be duly approved for
listing on such domestic securities exchange.

2.  Adjustment Rights.
    -----------------

    The Exercise Price and the number of Warrant Shares purchasable hereunder
are subject to adjustment, as follows:

    2.01  If the Corporation shall effect a subdivision or combination or
consolidation of shares (whether by way of stock split, reverse stock split or
otherwise) or other capital reorganization or reclassification of any class or
series of the capital stock of the Corporation for which this Warrant is then
exercisable, or the payment of a stock dividend or other distribution of stock
with respect to any such class or series of capital stock, then the number of
Warrant Shares purchasable hereunder and the Exercise Price shall be
appropriately adjusted in such a manner as to entitle the Warrantholder to
receive upon exercise of this Warrant, for the same aggregate consideration, the
same total number, type, class and series of securities and other property as
such Warrantholder would have received as a result of the event requiring the
adjustment had such Warrantholder exercised this Warrant in full immediately
prior to such event.

    2.02  If there shall occur any consolidation or merger of the Corporation
or sale of all or substantially all of the Corporation's assets, then as a
condition of such consolidation, merger or sale, lawful and adequate provision
shall be made whereby the Warrantholder shall thereafter have the right to
purchase and receive upon the basis and upon the terms and conditions herein
specified and in lieu of the Warrant Shares immediately theretofore purchasable
and receivable upon exercise of this Warrant, such securities and other property
as such Warrantholder would have received as a result of the event requiring the
adjustment had such Warrantholder exercised this Warrant in full immediately
prior to such event, and in any such case appropriate provision shall be made
with respect to the rights and interests of the Warrantholder to the end that
the provisions hereof shall thereafter be applicable, as nearly as may be, in
relation to the securities and other property thereafter deliverable upon the
exercise hereof.

    2.03  Upon the occurrence of any event specified in Subsection 2.01 or
Subsection 2.02, then, and in each such case, the Corporation shall give written
notice thereof to the Warrantholder in accordance with Subsection 1.04, which
notice shall state the adjustment in the Warrant Shares and the Exercise Price
resulting from such event, and shall set forth in reasonable detail the method
of calculation and the facts upon which such calculation is based.

    2.04  In case at any time: (1) the Corporation shall pay any dividend or
make any distribution (other than regular cash dividends from earnings or earned
surplus paid at an established rate) to the holders of its Series C Preferred
Stock or Common Stock or offer to all holders of its Series C Preferred Stock or
Common Stock the right to subscribe for the purchase of any shares of capital
stock or securities convertible into or exercisable for such shares of

                                      -3-
<PAGE>

capital stock; (2) there shall be any capital reorganization or reclassification
of the capital stock of the Corporation, or consolidation or merger of the
Corporation, or sale of all or substantially all of its assets; or (3) there
shall be a voluntary or involuntary dissolution, liquidation or winding-up of
the Corporation; then, in any one or more of such cases, the Corporation shall
give written notice thereof to the Warrantholder in accordance with Subsection
1.04, which notice shall state the date on which (a) the books of the
Corporation shall close or a record date shall be fixed for determining the
stockholders entitled to such dividend, distribution or subscription rights, or
(b) such reorganization, reclassification, consolidation, merger, sale,
dissolution, liquidation or winding-up shall take place, as the case may be.
Such notice shall also provide reasonable details of the proposed transaction
and specify the date as of which the record holders of Series C Preferred Stock
or Common Stock shall participate in such dividend, distribution or subscription
rights, or shall be entitled to exchange their Series C Preferred Stock or
Common Stock for securities or other property deliverable upon such
reorganization, reclassification, consolidation, merger, sale, dissolution,
liquidation or winding-up, as the case may be. Such written notice shall be
given at least fifteen (15) days prior to the action in question and not less
than fifteen (15) days prior to the record date or the date on which the
Corporation's transfer books are closed in respect thereto.

    2.05  Antidilution rights applicable to the Series C Preferred Stock
purchasable hereunder are set forth in the Corporation's Certificate of
Incorporation, as amended through the date hereof, a true and complete copy of
which has been furnished to Warrantholder (the "Charter").  The Corporation
shall promptly provide the Warrantholder with any restatement, amendment,
modification or waiver of the Charter and with any Certificate of Adjustment
sent to the holders of Series C Preferred Stock in accordance with the Charter
relating to any adjustment or readjustment of the Conversion Price of the Series
C Preferred Stock.

3.  Payment of Exercise Price.  The Exercise Price may be paid at the
    --------------------------
Warrantholder's election either (i) by cash, certified or official bank check,
or wire transfer of funds to an account designated by the Corporation, or (ii)
by surrender of Warrants ("Net Issuance") as determined below. If the
Warrantholder elects the Net Issuance method, the Corporation shall issue Series
C Preferred Stock or Common Stock as follows:

    (A)  Prior to the Automatic Conversion Effective Time (as defined in Section
4), the Corporation shall issue Series C Preferred Stock in accordance with the
following formula:

                 X    =    (Y)(A-B)/A

     Where:      X    =    the number of shares of Series C Preferred Stock to
                           be issued to the Warrantholder

                 Y    =    the number of shares of Series C Preferred Stock
                           requested to be exercised under this Warrant

                 A    =    the current fair market value of one (1) share of
                           Series C Preferred Stock

                 B    =    the Exercise Price

                                      -4-
<PAGE>

    As used herein, the current fair market value of a share of Series C
Preferred Stock shall mean the price per share which the Corporation could
obtain from a willing buyer for shares of Series C Preferred Stock, as
determined in good faith by the Corporation's Board of Directors, unless the
Corporation shall become subject to a merger, acquisition or other consolidation
pursuant to which the holders of Series C Preferred Stock receive securities
and/or other property in exchange for their Series C Preferred Stock, in which
case the fair market value of Series C Preferred Stock shall be deemed to be the
value of the securities and other property received by the holders of the
Corporation's Series C Preferred Stock per share of Series C Preferred Stock
pursuant to such merger, acquisition or other consolidation.

    (B)  Upon and after the Automatic Conversion Effective Time, the Corporation
shall issue Common Stock in accordance with the following formula:

                 X    =   (Y)(A-B)/A

     Where:      X    =   the number of shares of Common Stock to be issued to
                          the Warrantholder

                 Y    =   the number of shares of Common Stock requested to be
                          exercised under this Warrant

                 A    =   the fair market value of one (1) share of Common Stock

                 B    =   the Exercise Price

    As issued herein, current fair market value of Common Stock shall mean with
respect to each share of Common Stock:

         (i)   if the exercise is in connection with the Corporation's initial
    public offering of Common Stock, and if the Corporation's Registration
    Statement relating to such public offering has been declared effective by
    the SEC, then the initial "Price to Public" specified in the final
    prospectus with respect to the offering;

         (ii)  if this Warrant is exercised after, and not in connection with,
    the Corporation's initial public offering of Common Stock and

               (a) if the Common Stock is traded on a national securities
         exchange or quoted on the Nasdaq Stock Market, the fair market value
         shall be deemed to be the average of the closing prices over a twenty-
         one (21) day period ending three days before the day the current fair
         market value of the Common Stock is being determined; or

               (b) if the Common Stock is not listed on a national securities
         exchange or quoted on the Nasdaq Stock Market but is actively traded
         over-the-counter, the

                                      -5-
<PAGE>

         fair market value shall be deemed to be the average of the closing bid
         and asked prices reported by the National Quotation Bureau (or similar
         system) over the twenty-one (21) day period ending three days before
         the day the current fair market value of the Common Stock is being
         determined;

         (iii) if at any time the Common Stock is not listed on any national
    securities exchange or quoted on the Nasdaq Stock Market or actively traded
    or in the over-the- counter market, the current fair market value of Common
    Stock shall be the price per share which the Corporation could obtain from
    a willing buyer (not a current employee or director) for shares of Common
    Stock sold by the Corporation, from authorized but unissued shares, as
    determined in good faith by its Board of Directors, unless the Corporation
    shall become subject to a merger, acquisition or other consolidation
    pursuant to which the holders of Common Stock receive securities and/or
    other property in exchange for their Common Stock, in which case the fair
    market value of Common Stock shall be deemed to be the value of the
    securities and other property received by the holders of the Corporation's
    Common Stock per share of Common Stock pursuant to such merger, acquisition
    or other consolidation.

    Upon partial exercise of this Warrant, the Corporation shall promptly issue
an amended Warrant representing the remaining number of shares purchasable
hereunder.  All other terms and conditions of such amended Warrant shall be
identical to those contained herein, including, but not limited to the Effective
Date hereof.

4.  Automatic Conversion of Series C Preferred Stock.  If at any time the issued
    -------------------------------------------------
and outstanding shares of the Corporation's Series C Preferred Stock shall be
automatically converted into shares of Common Stock under the terms of the
Charter, then upon and after the effective time of such automatic conversion of
the Series C Preferred Stock (the "Automatic Conversion Effective Time"), the
right to purchase Series C Preferred Stock granted herein shall terminate, and
this Warrant shall represent the right to purchase a number of shares of Common
Stock calculated as follows:

              X   =   (Y)(Z)

    where:    X   =   the number of shares of Common Stock purchasable under
                      this Warrant upon and after such Automatic Conversion
                      Effective Time

              Y   =   the number of shares of Series C Preferred Stock
                      purchasable under this Warrant immediately prior to
                      such Automatic Conversion Effective Time

              Z   =   the number of shares of Common Stock issuable upon
                      conversion of each share of Series C Preferred Stock
                      immediately prior to such Automatic Conversion Effective
                      Time

                                      -6-
<PAGE>

    and the Exercise Price per share of Common Stock shall be a price calculated
    as follows:

              A   =   (B)(X)/Y

     where:   A   =   the Exercise Price per share of Common Stock upon and
                      after such Automatic Conversion Effective Time

              B   =   the Exercise Price per share of Series C Preferred Stock
                      immediately prior to such Automatic Conversion Effective
                      Time

              X   =   the number of shares of Series C Preferred Stock
                      purchasable under this Warrant immediately prior to such
                      Automatic Conversion Effective Time

              Y   =   the number of shares of Common Stock purchasable under
                      this Warrant upon and after such Automatic Conversion
                      Effective Time

    Thereafter, the number of shares of Common Stock purchasable hereunder and
the Exercise Price per share shall be subject to adjustment for the types of
events described in Section 2 above that occur with respect to the Common Stock.

5.  Restrictions.  The Warrant Shares issuable u upon exercise of this Warrant
    -------------
are subject to the terms and provisions of a Voting Agreement among the
Corporation and certain stockholders of the Corporation. The Corporation shall
furnish a copy of such Voting Agreement to any registered holder of this Warrant
or such Warrant Shares upon written request and without charge. Any certificate
or certificates representing Warrant Shares issued upon exercise of this Warrant
shall contain a legend to the foregoing effect.

6.  Miscellaneous.
    -------------

    6.01  No Rights as Stockholder.  This Warrant shall not entitle the
          ------------------------
Warrantholder to any voting rights or any other rights as a stockholder of the
Corporation, but upon presentation of this Warrant with the subscription form
annexed duly executed and the tender of payment of the Exercise Price at the
office of the Corporation pursuant to the provisions of this Warrant, the
Warrantholder shall forthwith be deemed a stockholder of the Corporation in
respect of the shares of Series C Preferred Stock or Common Stock so subscribed
and paid for.

    6.02   Governing Law.  This Warrant shall be governed by, and construed
           -------------
and enforced in accordance with, the substantive laws of The Commonwealth of
Massachusetts, without regard to its principles of conflicts of laws.

    6.03   Fractional Shares.  No fractional shares or scrip representing
           -----------------
fractional shares shall be issued upon exercise of this Warrant.  If, upon
exercise of this Warrant, the

                                      -7-
<PAGE>

Warrantholder would, except for the provisions of this Subsection 6.03, be
entitled to receive a fractional share of Series C Preferred Stock or Common
Stock, then the Corporation shall pay the exercising Warrantholder in cash an
amount equal to such fractional share multiplied by the fair market value (as
reasonably determined by the Corporation's Board of Directors) of one share of
Series C Preferred Stock or Common Stock, as the case may be.

    6.04   Headings.  The headings in the Warrant are inserted for
           --------
convenience of reference only and shall not affect the interpretation of this
Warrant.  Whenever from the context it appears appropriate, each term stated in
either the singular or plural shall include the singular and the plural, and
pronouns stated in either the masculine or the neuter gender shall include the
masculine, the feminine and the neuter.

    6.05   Substitution.  In case this Warrant shall be mutilated, lost,
           ------------
stolen or destroyed, the Corporation shall issue a new Warrant of like tenor and
denomination and deliver the same (a) in exchange and substitution for and upon
surrender and cancellation of any mutilated Warrant, or (b) in lieu of any
Warrant lost, stolen or destroyed, upon receipt of evidence satisfactory to the
Corporation of the loss, theft, or destruction of such Warrant (including a
reasonably detailed affidavit with respect to the circumstances of any loss,
theft or destruction), and an indemnity agreement reasonably satisfactory to the
Corporation.

    6.06   Modification.  This Warrant and any term hereof may be changed,
           ------------
waived, discharged or terminated only by an instrument in writing signed by the
party against which enforcement of such change, waiver, discharge or termination
is or may be sought.


    IN WITNESS WHEREOF, the Corporation has caused this Stock Purchase Warrant
to be signed by its President thereunto duly authorized and its corporate seal
to be hereunto affixed and attested by its Secretary.

Dated: ________________________          SEQUENOM,, INC

(Corporate Seal)

Attest:                                  By:___________________________
                                            Its President

________________________________
Secretary

                                      -8-
<PAGE>

                          WARRANTHOLDER'S ACCEPTANCE
                          --------------------------


    The undersigned hereby accepts the foregoing warrant and agrees to the
terms and conditions thereof.


                              WARRANTHOLDER


                              By:____________________________
<PAGE>

                               SUBSCRIPTION FORM
                               -----------------


    The undersigned, the registered holder of the within Stock Purchase
Warrant, hereby irrevocably elects to exercise the purchase right represented by
such Warrant for, and to purchase thereunder, _______ shares of Series C
Convertible Preferred Stock, par value $.001 per share, of Sequenom, Inc., and
herewith makes payment of $ ____________ therefor and requests that the
certificates representing such shares be issued in the name of and delivered to
____________ and if such shares shall not include all of the shares issuable
under this Warrant, that a new Warrant of like tenor and date be delivered to
the undersigned for the shares not issued.

Dated:_______________________________        _______________________________
                                             Name of Registered Holder


                                             _______________________________
                                             Authorized Signature
<PAGE>

                              FORM OF ASSIGNMENT
                              ------------------

    For value received the undersigned hereby sells, assigns and transfers unto
________________________, whose address is __________________________________,
the within Stock Purchase Warrant with respect to _________ shares of Series C
Convertible Preferred Stock purchasable thereby, and does hereby irrevocably
constitute and appoint _______________ attorney to transfer the within Warrant
on the books of Sequenom, Inc. with full power of substitution in the premises.


Dated:__________________________              ______________________________
                                              Name of Registered Holder


In the presence of:


________________________________              ______________________________
                                              Authorized Signature
<PAGE>

                             SCHEDULE OF INVESTORS


                                                           Number of Shares
Initial Investor                                          Subject to Warrant
- -----------------------------------------------------------------------------
TVM Techno Venture                                               7,606
 Enterprises No. 11
 Limited Partnership
c/o TVM Techno Venture
 Management ("TVM")
 101 Arch Street, Suite 1950
 Boston, MA 02210

TVM Intertech                                                    5,070
 Limited Partnership
c/o TVM

TVM Zweite Beteiligung-US                                       15,212
 Limited Partnership
 c/o TVM

TVM Eurotech Limited                                            10,141
 Partnership
c/o TVM

TVM Techno Venture                                                 825
 Investors No. 1
 Limited Partnership
c/o TVM

KBL Founder Ventures SCA                                         8,761
43, Boulevard Royal
L-2955 Luxembourg

Alpinvest International B.V.                                    31,746
Gooimeer 3
NL-1410 AB Naarden
The Netherlands

Hellmut Kirchner                                                 1,587
Martelsgraben 2
82327 Tutzing
Germany

Hellmut Kirchner,                                               22,222
 as Trustee
Martelsgraben 2
82327 Tutzing
Germany
<PAGE>

                                                           Number of Shares
Initial Investor                                          Subject to Warrant
- -----------------------------------------------------------------------------
Franz A. Wirtz                                                   1,666
Atzenach 37
D-52223 Stolberg
Germany

Hannemarie Wirtz                                                 1,666
Atzenach 37
D-52223 Stolberg
Germany

TOTAL                                                          106,502

<PAGE>

                                                                    EXHIBIT 10.4

                        SERIES D CONVERTIBLE PREFERRED
                           STOCK PURCHASE AGREEMENT

    THIS AGREEMENT made as of the 21st day of December, 1998, by and among
Sequenom, Inc., a Delaware corporation (the "Corporation"); the several
investors named on the Schedule of Investors attached hereto (individually, an
"Initial Investor", and collectively, the "Initial Investors"); such additional
investors as may be identified on such addenda to the Schedule of Investors as
may be agreed upon by the Corporation and such additional investors in
accordance with the terms of this Agreement (individually, an "Additional
Investor", and collectively, the "Additional Investors")(the Initial Investors
and the Additional Investors being hereinafter sometimes referred to
individually as an "Investor" and collectively as the "Investors"); and, solely
for purposes of Section 8.1 hereof, Hubert Koster, Nola E. Masterson, and Robert
E. Patterson (individually a "Founder" and collectively the "Founders") and each
holder of the Corporation's Series B Convertible Preferred Stock (the "Series B
Investors") and Series C Convertible Preferred Stock (the "Series C Investors").

    WHEREAS, the Initial Investors wish to purchase from the Corporation, and
the Corporation wishes to sell to the Investors, up to an aggregate of 6,153,850
shares of the Corporation's Series D Convertible Preferred Stock, par value
$.001 per share (the "Series D Preferred");

    WHEREAS, the Corporation wishes to sell to the Additional Investors up to
an aggregate number of shares of Series D Preferred equal to the difference
between 6,153,850 and the number of shares of Series D Preferred sold at the
Initial Closing (as hereinafter defined); and

    WHEREAS, pursuant to that certain Stock Purchase Agreement dated as of May
8, 1997 and amended as of January 12, 1998 (the "Series C Purchase Agreement")
the Corporation granted certain rights of first refusal to the Series C
Investors, the Series B Investors and the Founders, and the Corporation, such
Series C Investors, Series B Investors and the Founders now desire to amend and
restate such rights of first refusal in the Series C Purchase Agreement with the
rights of first refusal set forth in Section 8.1 hereof.

    NOW, THEREFORE, in consideration of the premises and the mutual covenants
and agreements herein contained, the parties hereby agree as follows:

    SECTION 1.  Amendment of Certificate of Incorporation.  Immediately prior to
    ----------  -----------------------------------------
the execution and delivery of this Agreement, the Corporation filed with the
Secretary of State of Delaware an Amended and Restated Certificate of
Incorporation (the "Certificate of Incorporation"), a copy of which is attached
hereto as Exhibit 1, for the purpose of increasing and amending the authorized
          ---------
capital stock of the Corporation and setting forth the designations and the
powers, preferences and rights, and the qualifications, limitations and
restrictions thereof, granted to or imposed upon the capital stock of the
Corporation or the holders thereof.

    SECTION 2.  Purchase and Sale of the Series D Preferred.
    ----------  -------------------------------------------

    2.1  Initial Shares.  Subject to the terms and conditions of this Agreement,
         --------------
at the Initial Closing (as defined in Section 3.1), the Corporation agrees to
issue and sell to each Initial
<PAGE>

Investor the number of shares of Series D Preferred set forth opposite the name
of such Initial Investor on the Schedule of Investors, at a purchase price equal
                                ---------------------
to $6.50 per share of Series D Preferred and an aggregate purchase price as set
forth on the Schedule of Investors, and each Initial Investor, acting severally
             ---------------------
and not jointly, hereby agrees to purchase from the Corporation such number of
shares of Series D Preferred at such purchase price. The shares of Series D
Preferred sold at the Initial Closing are hereafter referred to as the "Initial
Shares."

    2.2  Additional Shares.  Subject to the terms and conditions of this
         -----------------
Agreement, from time to time after the Initial Closing, but on or before
December 31, 1998, the Corporation agrees to issue and sell to one or more
Additional Investors who enter into this Agreement by executing one or more
counterparts hereof up to an aggregate number of shares of Series D Preferred
equal to 6,153,850 minus the number of Initial Shares (the "Additional Shares").
By executing such a counterpart, each such Additional Investor shall agree to
purchase that number of Additional Shares as may be set forth opposite its name
on such addenda to the Schedule of Investors which may be agreed upon between
                       ---------------------
the Corporation and each such Additional Investor, at the purchase price of
$6.50 per share and at the aggregate purchase price set forth opposite such
Additional Investor's name on such addenda. Each such addendum shall be executed
by the Corporation and each such Additional Investor, a copy of each such
addendum shall be delivered to each Investor, and each such addendum shall be
deemed a part of this Agreement ab initio. Initial Investors may become
                                ---------
Additional Investors.


    The Initial Shares and the Additional Shares are referred to collectively
hereinafter as the "Shares".

    SECTION 3.  Closings.
    ----------  --------

    3.1  Initial Closing.  The closing of the sale and purchase of the Initial
         ---------------
Shares (the "Initial Closing") shall take place simultaneously with the
execution of this Agreement at the offices of Brobeck, Phleger & Harrison LLP,
550 West C Street, Suite 1300, San Diego, California 92101, on December 21, 1998
(the "Initial Closing Date"), or at such other location, date and time as may be
agreed upon between the Initial Investors and the Corporation. At the Initial
Closing, the Corporation shall issue and deliver to each Initial Investor a
certificate or certificates registered in the name of such Initial Investor,
representing the Initial Shares being purchased by it at the Initial Closing,
against payment by such Initial Investor to the Corporation of the purchase
price therefor in the form of (a) a check payable to the order of the
Corporation, (b) a wire transfer to the account of the Corporation, (c)
cancellation of indebtedness of the Corporation to such Investor or an affiliate
of such Investor, (d) conversion of convertible promissory notes issued by the
Corporation to such Investor or an affiliate of such Investor, or (e) any
combination thereof.

    3.2  Additional Closings.  The closings of the sale and purchase of the
         -------------------
Additional Shares under this Agreement (the "Additional Closings") shall take
place at such time, date and place as are mutually agreeable to the Corporation
and any Additional Investor, but such Additional Closings, if any, shall take
place on or before December 31, 1998. At the Additional Closings, the
Corporation shall issue and deliver to each Additional Investor a certificate or
certificates registered in the name of such Additional Investor, representing
the Additional Shares being purchased by it at the Additional Closing, against
payment by such Additional

                                       2
<PAGE>

Investor to the Corporation of the purchase price therefor in the form of (a) a
check payable to the order of the Corporation, (b) a wire transfer to the
account of the Corporation, (c) cancellation of indebtedness of the Corporation
to such Additional Investor or an affiliate of such Additional Investor, (d)
conversion of convertible promissory notes issued by the Corporation to such
Additional Investor or an affiliate of such Additional Investor, or (e) any
combination thereof.

    SECTION 4.  Representations and Warranties of the Corporation. The
    ----------  -------------------------------------------------
Corporation hereby represents and warrants to the Investors as of the date of
this Agreement as follows:

    4.1  Organization.  The Corporation is a corporation duly organized, validly
         ------------
existing and in good standing under the laws of the State of Delaware and has
all requisite corporate power and authority to own and lease its properties, to
carry on its business as presently conducted and as proposed to be conducted and
to carry out the transactions contemplated hereby. Except as set forth in
Exhibit 4.1, the Corporation is duly qualified as a foreign corporation and is
- -----------
in good standing in all such other jurisdictions (which jurisdictions are listed
in Exhibit 4.1) in which the conduct of its business or its ownership or leasing
   -----------
of property requires such qualification and in which the failure so to qualify
or so to be in good standing would have a materially adverse effect on the
Corporation's operations or financial condition. Exhibit 4.1 contains a true,
                                                 -----------
complete and accurate copy of the By-Laws, as amended to date, of the
Corporation (the "By-Laws").

   4.2   Capitalization.  The entire authorized capital stock of the Corporation
         --------------
consists of:

         (a)  34,960,347 shares of Common Stock, par value $.001 per share (the
"Common Stock");

         (b)  1,650,000 shares of Series A Convertible Preferred Stock, par
value $.001 per share (the "Series A Preferred");

         (c)  2,976,663 shares of Series B Convertible Preferred Stock, par
value $.001 per share (the "Series B Preferred");

         (d)  4,679,834 shares of Series C Convertible Preferred Stock, par
value $.001 per share (the "Series C Preferred"); and

         (e)  6,153,850 shares of Series D Preferred Stock.

    The number of shares of Common Stock, Series A Preferred, Series B
Preferred and Series C Preferred that are issued and outstanding or held as
treasury shares as of the date hereof is as set forth in Exhibit 4.2.  All
                                                         -----------
issued and outstanding shares of Common Stock, Series A Preferred, Series B
Preferred and Series C Preferred are validly issued, fully paid and
nonassessable.  The number of shares of Common Stock reserved for issuance upon
the exercise of options granted and to be granted, and upon conversion of the
Series A Preferred, the Series B Preferred, the Series C Preferred and the
Series D Preferred, is as set forth in Exhibit 4.2.  Prior to the Initial
                                       -----------
Closing, no shares of Series D Preferred were issued or outstanding.

                                       3
<PAGE>

    Exhibit 4.2 contains a list of all holders of capital stock of the
    -----------
Corporation and options, warrants or rights to purchase such capital stock, in
each case including the number of shares of capital stock held by, or subject to
purchase pursuant to the exercise of any option, warrant or right held by, each
such holder.  Except as set forth in Exhibit 4.2, there are no outstanding
                                     -----------
shares of capital stock of the Corporation or warrants, options, agreements,
convertible securities or other commitments pursuant to which the Corporation is
or may become obligated to issue any shares of its capital stock or other
securities of the Corporation.  Except as set forth in Exhibit 4.2, the number
                                                       -----------
of shares of capital stock, if any, reserved for issuance in connection with the
securities described in the immediately preceding sentence is not subject to
adjustment by reason of the issuance of the Shares or the Reserved Shares (as
defined in Section 4.16).  Except as set forth in Section 8.1 or in Exhibit 4.2,
                                                                    -----------
there are no preemptive or similar rights to purchase or otherwise acquire
shares of capital stock of the Corporation pursuant to any provision of law, the
Certificate of Incorporation or the By-Laws or any agreement to which the
Corporation is a party, or otherwise, and except as set forth in the Voting
Agreement, the Registration Rights Agreement and the Stock Restriction Agreement
described in Section 4.16 of this Agreement, there is no agreement, restriction
or encumbrance with respect to the sale or voting of any shares of the
Corporation's capital stock (whether outstanding or issuable upon conversion or
exercise of outstanding securities) imposed by or through the Certificate of
Incorporation, By-Laws or any agreement to which the Corporation is a party.

    4.3  Equity Investments.  Except as set forth on Exhibit 4.3, the
         ------------------                          -----------
Corporation does not currently have any subsidiaries nor currently own any
capital stock or other proprietary interest, directly or indirectly, in any
corporation, association, trust, partnership, joint venture or other entity.

    4.4  Financial Statements.  Attached as Exhibit 4.4 are the audited
         --------------------               -----------
financial statements of the Corporation for the years ended December 31, 1997
and 1996, and for the period from February 14, 1994 (inception) to December 31,
1997, along with the unaudited balance sheet of the Corporation as of September
30, 1998 (the "Balance Sheet") and the related unaudited statement of income for
the nine months ended September 30, 1998 (September 30, 1998 is hereinafter
sometimes referred to as the "Balance Sheet Date"). All such financial
statements are in accordance with the books and records of the Corporation and
present fairly the financial position and results of operations of the
Corporation as of the dates and for the periods indicated in accordance with
generally accepted accounting principles consistently applied, except that the
unaudited financial statements may not contain all footnotes required by
generally accepted accounting principles.

    4.5  Absence of Undisclosed Liabilities.  Except as set forth in Exhibit 4.5
         ----------------------------------                          -----------
or as reflected in the Balance Sheet, at the Balance Sheet Date (a) the
Corporation had no material liabilities of any nature (matured or unmatured,
fixed or contingent) of a type required by generally accepted accounting
principles to be disclosed on a balance sheet of the Corporation which were not
so disclosed; (b) all reserves established by the Corporation and set forth in
the Balance Sheet were adequate; and (c) there were no loss contingencies (as
such term is used in Statement of Financial Accounting Standards No. 5 issued by
the Financial Accounting Standards Board in March 1975) which were not
adequately disclosed in the Balance Sheet as required by such Statement No. 5.

                                       4
<PAGE>

   4.6   Absence of Changes.  Except as set forth in Exhibit 4.6, since the
         ------------------                          -----------
Balance Sheet Date there has not been (a) any material adverse change in the
financial condition, results of operations, assets, liabilities, business or
prospects of the Corporation, (b) any material asset or property of the
Corporation made subject to a lien of any kind, (c) any waiver of any valuable
right of the Corporation, or the cancellation of any debt or claim held by the
Corporation, (d) any payment of dividends on, or other distribution with respect
to, or any direct or indirect redemption or acquisition of, any shares of the
capital stock of the Corporation, or any agreement or commitment therefor, (e)
any mortgage, pledge, sale, assignment or transfer of any tangible or intangible
assets of the Corporation, except in the ordinary course of business, (f) any
loan by the Corporation to, or any loan to the Corporation from, any officer,
director, employee or stockholder of the Corporation, or any agreement or
commitment therefor, (g) any damage, destruction or loss (whether or not covered
by insurance) materially and adversely affecting the assets, property or
business of the Corporation, or (h) any change in the accounting methods or
practices followed by the Corporation.

    4.7  Encumbrances.  Except as set forth in Exhibit 4.7, the Corporation has
         ------------                          -----------
good title to all of its property and assets, real, personal or mixed, tangible
or intangible, free and clear of all liens, security interests, charges and
other encumbrances of any kind.

    4.8  Intellectual Property Rights.  Except in each case as set forth in
         ----------------------------
Exhibit 4.8:
- -----------

         (a)  the Corporation owns or has the right to use all Intellectual
Property Rights (as hereinafter defined) necessary or required for the conduct
of its business as presently conducted or as proposed to be conducted;

         (b)  to the Corporation's knowledge, no royalties or other amounts are
payable by the Corporation to other persons by reason of the ownership or use of
said Intellectual Property Rights; and

         (c)  to the Corporation's knowledge, no product marketed or sold or
proposed to be marketed or sold by the Corporation violates or will violate any
license or infringes any Intellectual Property Rights of another, nor has the
Corporation received any notice that any of such Intellectual Property Rights or
the operation or proposed operation of the Corporation's business conflicts or
will conflict with the rights of others.

    As used herein, the term "Intellectual Property Rights" means all patents,
trademarks, service marks, trade names, copyrights, inventions, trade secrets,
proprietary processes and formulae, applications for patents, trademarks,
service marks and copyrights, and other industrial and intellectual property
rights.  A list of the Corporation's patents is set forth in Exhibit 4.8.
                                                             -----------

    Dr. Hubert Koster has entered into agreements with the Company relating to
protection of proprietary information and invention assignment.

    4.9  Litigation.  There is no action, suit, claim, proceeding or
         ----------
investigation, at law, in equity or otherwise, or by or before any governmental
instrumentality or other agency, now pending, or, to the Corporation's
knowledge, threatened against the Corporation.

                                       5
<PAGE>

    4.10  No Defaults.  The Corporation is not in violation or breach of, or in
          -----------
default under, any provision of (a) the Certificate of Incorporation or the By-
Laws or (b) except where any such violation, breach or default would not have a
material adverse effect on the Corporation, any note, indenture, mortgage,
lease, contract, purchase order or other instrument, document or agreement to
which the Corporation is a party or by which it or any of its property is bound
or affected or any ruling, writ, injunction, order, judgment or decree of any
court, administrative agency or other governmental body, except as set forth in
Exhibit 4.14.  To the Corporation's knowledge, there exists no condition, event
- ------------
or act which after notice, lapse of time, or both, would constitute a violation
or breach of, or a default under, any of the foregoing.

    4.11  Employment of Officers, Employees and Consultants.  To the
          -------------------------------------------------
Corporation's knowledge, no third party may assert any valid claim against the
Corporation, any Investor, or any Designated Person (as hereinafter defined)
with respect to (a) the continued employment by or association with the
Corporation of any of the present officers or key employees of, or consultants
to, the Corporation (collectively, the "Designated Persons"), or (b) the use or
disclosure by the Corporation or any Designated Person of any information which
the Corporation or any Designated Person would be prohibited from using or
disclosing under any prior agreements or arrangements or under any laws,
including, without limitation, laws applicable to unfair competition, trade
secrets or proprietary information.

    4.12  Taxes.  The Corporation has filed all Federal, state, local and
          -----
foreign tax returns which are required to be filed by it and all such returns
are true and correct. The Corporation has paid all taxes pursuant to such
returns or pursuant to any assessments received by it or which it is obligated
to withhold from amounts owing to any employee, creditor or third party, except,
in each case, for those which are not yet due and payable pursuant to such
returns.

    4.13  Agreements.  Except as set forth in Exhibit 4.13, the Corporation is
          ----------                          ------------
not a party to any written or oral (a) contract with any labor union; (b)
contract for the future purchase of fixed assets or for the future purchase of
materials, supplies or equipment in excess of normal operating requirements; (c)
contract for the employment of any officer, individual employee or other person
or any contract with any person on a consulting basis; (d) bonus, pension,
profit-sharing, retirement, stock purchase, stock option, hospitalization,
medical insurance or similar plan, contract or understanding in effect with
respect to employees or any of them or the employees of others; (e) agreement or
indenture relating to the borrowing of money or to the mortgaging, pledging or
otherwise placing a lien on any assets of the Corporation; (f) guaranty of any
obligation for borrowed money or otherwise; (g) lease or agreement under which
the Corporation is lessee of or holds or operates any property, real or
personal, owned by any other party; (h) lease or agreement under which the
Corporation is lessor of or permits any third party to hold or operate any
property, real or personal, owned or controlled by the Corporation; (i) license
or lease agreement with respect to any Intellectual Property Rights; (j)
agreement or other commitment for capital expenditures in excess of $25,000; or
(k) contract, agreement or commitment under which the Corporation is obligated
to pay any broker's fees, finder's fees or any such similar fees, to any third
party. The Corporation has furnished to the Investors true and correct copies of
all such agreements and other documents requested by the Investors or their
authorized representatives.

                                       6
<PAGE>

    4.14  Compliance.  Except as set forth in Exhibit 4.14, the Corporation has
          ----------                          ------------
complied in all material respects with all Federal, state, local or foreign laws
applicable to its business. Except as set forth in Exhibit 4.14, the Corporation
                                                   ------------
has all Federal, state, local and foreign governmental licenses, registrations
and permits material to or necessary for the conduct of its business, and,
except as set forth in Exhibit 4.14, such licenses, registrations and permits
                       ------------
are in full force and effect and there have been no violations in any material
respect of any such licenses, registrations or permits. No proceeding is pending
or, to the Corporation's knowledge, threatened, to revoke or limit any thereof.

    4.15  Insurance.  Exhibit 4.15 sets forth each insurance policy (specifying
          ---------
the insurer, the amount of coverage, the type of insurance, the policy number,
the expiration date, the annual premium and any pending claims thereunder)
maintained by the Corporation on its properties, assets, business or personnel.
The insurance maintained by the Corporation on its properties, assets, business
and personnel is in amounts deemed adequate by the Corporation, is in accordance
with the standards of the industry in which the Corporation operates, and is
under policies currently in effect and issued by insurers of recognized
responsibility.

    4.16  Authorization of this Agreement.  The execution, delivery and
          -------------------------------
performance by the Corporation of this Agreement, the Amended and Restated
Registration Rights Agreement of even date herewith by and among the
Corporation, the Investors and certain additional parties identified therein,
which agreement is in the form of Exhibit 4.16A (the "Registration Rights
                                  -------------
Agreement"), the Amended and Restated Voting Agreement of even date herewith by
and among the Corporation, the Investors and certain additional parties
identified therein, which agreement is in the form of Exhibit 4.16B (the "Voting
                                                      -------------
Agreement"), and the Amended and Restated Stock Restriction Agreement of even
date herewith by and among the Corporation, the Investors and certain additional
parties identified therein, which agreement is in the form of Exhibit 4.16C (the
                                                              -------------
"Stock Restriction Agreement"; this Agreement, the Registration Rights
Agreement, the Voting Agreement and the Stock Restriction Agreement are
hereinafter referred to collectively as the "Transaction Documents") have been
duly authorized by all requisite corporate action. The Transaction Documents
have been duly executed and delivered on behalf of the Corporation and
constitute the valid and binding obligations of the Corporation, enforceable in
accordance with their respective terms except (i) as limited by applicable
bankruptcy, insolvency, reorganization, moratorium, and other laws of general
application affecting enforcement of creditors' rights generally, (ii) as
limited by laws relating to the availability of specific performance, injunctive
relief, or other equitable remedies, and (iii) to the extent that the
indemnification provisions contained in the Registration Rights Agreement may be
limited by applicable laws. The execution, delivery and performance of the
Transaction Documents, the issuance, sale and delivery of the Shares and the
shares of Common Stock issuable upon conversion of the Shares (collectively, the
"Reserved Shares"), and compliance with the provisions hereof and thereof by the
Corporation, do not and will not, with or without the passage of time or the
giving of notice or both, (a) violate any provision of law, statute, rule or
regulation or any ruling, writ, injunction, order, judgment or decree of any
court, administrative agency or other governmental body or (b) conflict with or
result in any breach of any of the terms, conditions or provisions of, or
constitute a default (or give rise to any right of termination, cancellation or
acceleration) under, or result in the creation of any lien, security interest,
charge or encumbrance upon any of the properties or assets of the Corporation
under, the Certificate of Incorporation or By-Laws or any note,

                                       7
<PAGE>

indenture, mortgage, lease, contract, purchase order or other instrument,
document or agreement to which the Corporation is a party or by which it or any
of its property is bound or affected except to the extent that any such
violation, conflict, breach, default, lien, security interest, charge or
encumbrance would not have a material adverse effect on the Corporation.

    4.17  Authorization of Shares.  The issuance, sale and delivery hereunder by
          -----------------------
the Corporation of the Shares have been duly authorized by all requisite
corporate action, and when so issued, sold and delivered, the Shares will be
fully paid and nonassessable and the Shares will be validly issued and
outstanding and not subject to preemptive or any other similar rights of the
stockholders of the Corporation or others.

    4.18  Authorization of Reserved Shares.  The issuance, sale and delivery by
          --------------------------------
the Corporation of the Reserved Shares have been duly authorized by all
requisite corporate action of the Corporation, and the Reserved Shares have been
duly reserved for issuance upon conversion of the Shares, and when so issued,
sold and delivered upon conversion of the Shares, the Reserved Shares will be
validly issued and outstanding, fully paid and nonassessable, and not subject to
preemptive or any other similar rights of the stockholders of the Corporation or
others.

    4.19  Related Transactions.  Except as set forth in Exhibit 4.19, no
          --------------------
director, officer or employee of the Corporation nor any "associate" (as defined
in the rules and regulations promulgated under the Securities Exchange Act of
1934 (the "Exchange Act")) of any such person is indebted to the Corporation,
nor is the Corporation indebted (or committed to make loans or extend or
guarantee credit) to any such person, nor is any such person a party to any
transaction (other than as an employee or consultant) with the Corporation
providing for the furnishing of services by, or rental of real or personal
property from, or otherwise requiring cash payments to, any such person.

    4.20  No Governmental Consent or Approval Required.  Except as set forth in
          --------------------------------------------
Exhibit 4.20, no authorization, consent, approval or other order of, declaration
- ------------
to, or filing with, any governmental agency or body is required to be made or
obtained by the Corporation for or in connection with the valid and lawful
authorization, execution and delivery by the Corporation of the Transaction
Documents, for or in connection with the valid and lawful authorization,
issuance, sale and delivery of the Shares or for or in connection with the valid
and lawful authorization, reservation, issuance, sale and delivery of the
Reserved Shares, except such exemptive filings as are required to be made under
applicable securities laws and have been and shall be made on a timely basis.

    4.21  Registration Rights.  Except as contemplated by the Registration
          -------------------
Rights Agreement, no person has any right to cause the Corporation to effect the
registration under the Securities Act of 1933, as amended (the "Securities
Act"), of any securities of the Corporation.

    4.22  Exemptions from Securities Laws.  Subject to the accuracy of the
          -------------------------------
representations and warranties of the Investors set forth in Section 5 hereof,
the provisions of Section 5 of the Securities Act are inapplicable to the
offering, issuance, sale and delivery of the Shares and the Reserved Shares, and
no consent, approval, qualification or registration or filing under any state
securities laws is required in connection therewith, except such exemptive
filings as are required to be made under applicable securities laws and have
been and shall be made on a timely basis.

                                       8
<PAGE>

    4.23  Commitments from German Government.  Exhibit 4.23 accurately describes
          ----------------------------------   ------------
certain commitments from certain German governmental authorities made with
respect to the Corporation and its subsidiary Sequenom Instruments GmbH.

    SECTION 5.  Representations and Warranties of the Investors.  Each Investor,
    ----------  -----------------------------------------------
severally and not jointly, represents and warrants to the Corporation as of the
date of this Agreement as follows:

    5.1   Organization.  If other than an individual, such Investor is an entity
          ------------
duly organized, validly existing and in good standing under the laws of the
jurisdiction of its organization, with all requisite power and authority to own
and lease its properties, to carry on its business, and to carry out the
transactions contemplated hereby.

    5.2   Purchase for Investment.  Such Investor is acquiring the Shares, and,
          -----------------------
in the event such Investor should acquire Reserved Shares upon conversion of the
Shares, such Investor will be acquiring such Reserved Shares, for its own
account, for investment and not for, with a view to, or in connection with, any
distribution or public offering thereof within the meaning of the Securities
Act.

    5.3   Unregistered Securities; Legend.  Such Investor understands that the
          -------------------------------
Shares have not been, and the Reserved Shares will not be, registered under the
Securities Act or any state securities law, by reason of their issuance in a
transaction exempt from the registration requirements of the Securities Act and
such laws, and that they must be held indefinitely unless they are subsequently
registered under the Securities Act and such laws or a subsequent disposition
thereof is exempt from registration. Such Investor further understands that such
exemption depends upon, among other things, the bona fide nature of such
Investor's investment intent expressed herein. Such Investor acknowledges that
the certificates for the Shares and the Reserved Shares shall bear a legend to
such effect, and appropriate transfer instructions may be issued.

    5.4   Status of the Investors.  Such Investor has not been formed for the
          -----------------------
specific purpose of acquiring Shares or Reserved Shares pursuant to this
Agreement. Such Investor understands the term "accredited investor," as used in
Regulation D promulgated under the Securities Act and represents and warrants to
the Corporation that such Investor is an "accredited investor" for purposes of
acquiring Shares and Reserved Shares.

    5.5   Knowledge and Experience; Economic Risk.  Such Investor has sufficient
          ---------------------------------------
knowledge and experience in business and financial matters and with respect to
investment in securities of privately held companies so as to enable it to
analyze and evaluate the merits and risks of the investment contemplated hereby
and is capable of protecting its interest in connection with this transaction.
Such Investor is able to bear the economic risk of such investment, including a
complete loss of the investment.

    5.6   Access to Information.  Such Investor acknowledges that such Investor
          ---------------------
and its representatives have had the opportunity to ask questions and receive
answers from officers and representatives of the Corporation concerning the
transactions contemplated by this Agreement, and to obtain any additional
information which the Corporation possesses or can acquire that is

                                       9
<PAGE>

necessary to verify the accuracy of the information regarding the Corporation
herein set forth or otherwise desired in connection with its purchase of the
Shares purchasable by it.

    5.7   Authorization.  The execution, delivery and performance by such
          -------------
Investor of this Agreement have been duly authorized by all requisite action of
such Investor and its partners or equity holders. This Agreement has been duly
executed and delivered on behalf of such Investor and constitutes the valid and
binding obligation of such Investor, enforceable in accordance with its terms
except (i) as limited by applicable bankruptcy, insolvency, reorganization,
moratorium, and other laws of general application affecting enforcement of
creditors' rights generally and (ii) as limited by laws relating to the
availability of specific performance, injunctive relief or other equitable
remedies. The execution, delivery and performance of the Transaction Documents,
the purchase of the Shares and compliance with the provisions hereof and thereof
by such Investor, do not and will not, with or without the passage of time or
the giving of notice or both, (a) violate any provision of law, statute, rule or
regulation or any ruling, writ, injunction, order, judgment or decree of any
court, administrative agency or other governmental body or (b) conflict with or
result in any breach of any of the terms, conditions or provisions of, or
constitute a default (or give rise to any right of termination, cancellation or
acceleration) under, such Investor's charter, by-laws, partnership agreement or
other organizational document, or any material note, indenture, mortgage, lease,
agreement, contract, purchase order or other instrument, document or agreement
to which such Investor is a party or by which it or any of its property is bound
or affected except to the extent that any such violation, conflict, breach or
default would not have a material adverse effect on such Investor.

    5.8   No Governmental Consent or Approval Required.  No authorization,
          --------------------------------------------
consent, approval or other order of, or declaration to, or filing with, any
governmental agency or body is required to be made or obtained by such Investor
for or in connection with the valid authorization, execution and delivery by
such Investor of the Transaction Documents or for the valid purchase by such
Investor of the Shares hereunder or for or in connection with the issuance to
such Investor of any Reserved Shares.

    5.9   Rule 144.  Such Investor understands that the exemption from
          --------
registration afforded by Rule 144 (the provisions of which are known to such
Investor) promulgated by the Securities and Exchange Commission (the
"Commission") under the Securities Act depends upon the satisfaction of various
conditions, that such exemption is not currently available and that, if
applicable, Rule 144 affords the basis for sales only in limited amounts.

    SECTION 6.  Conditions Precedent to Closing by the Investor.  The obligation
    ---------   -----------------------------------------------
of each Investor to purchase and pay for the Shares being purchased by such
Investor is subject to satisfaction (or waiver by the Investor) of the following
conditions precedent at the Initial Closing:

    6.1   Corporate Proceedings.  All corporate and other proceedings to be
          ---------------------
taken and all waivers and consents to be obtained in connection with the
transactions contemplated by this Agreement shall have been taken or obtained
and all documents incident to such transactions shall be satisfactory in form
and substance to the Investors and their counsel, who shall have received all
such originals or certified or other copies of such documents as they may
reasonably request.

                                       10
<PAGE>

    6.2   Representations and Warranties Correct.  The representations and
          --------------------------------------
warranties made by the Corporation in Section 4 hereof shall be true and correct
when made, and shall be true and correct in all material respects at the time of
the Initial Closing with the same force and effect as if they had been made at
and as of the time of the Initial Closing.

    6.3   Compliance with Covenants.  The Corporation shall have duly complied
          -------------------------
with and performed all covenants and agreements of the Corporation herein which
are required to be complied with and performed at or before the Initial Closing.

    6.4   Certificate of Compliance.  The Corporation shall have provided at the
          -------------------------
Initial Closing a certificate, dated the date of the Initial Closing, in form
and substance reasonably satisfactory to such Investor, confirming compliance
with the conditions set forth in Sections 6.2 and 6.3.

    6.5   Opinion of Counsel.  At the Initial Closing, each of the Investors
          ------------------
purchasing Shares shall have received from Brobeck, Phleger & Harrison LLP,
counsel for the Corporation, an opinion addressed to such Investors, dated the
date of such Closing, to the effect set forth in Exhibit 6.5.
                                                 -----------

    6.6   Related Agreements and Documents.  At or before the Initial Closing,
          --------------------------------
the parties thereto shall have executed and delivered the Registration Rights
Agreement, the Voting Agreement and the Stock Restriction Agreement, and the
Corporation shall have delivered to the Investors such other documents as they
shall reasonably request.

    6.7   Blue Sky Matters.  All consents, approvals, qualifications,
          ----------------
registrations and filings required to be obtained or effected under any
applicable state securities or "blue sky" laws in connection with the issuance,
sale and delivery of the Shares prior to the sale of the Shares shall have been
obtained or effected and copies of the same delivered to each of the Investors.

    6.8   Subscription by Other Investors.  Initial Shares in an amount which
          -------------------------------
would result in at least $20,000,000 in aggregate proceeds to the Company shall
have been subscribed for at the Initial Closing.

    SECTION 7.  Financial Reports.  Subject to the limitations set forth in
    ----------  -----------------
Section 7.6, the Corporation agrees to furnish each of the Investors and any
transferee to which any Investor transfers at least 100,000 Shares (a "Series D
Transferee") with the following:

    7.1   Quarterly Reports.  Within 45 days after the end of each fiscal
          -----------------
quarter, an unaudited financial report of the Corporation, which report shall be
prepared in accordance with generally accepted accounting principles
consistently applied (except that the financial report may (i) be subject to
normal year-end audit adjustments neither individually nor in the aggregate
material and (ii) not contain all notes thereto which may be required in
accordance with generally accepted accounting principles) and shall be certified
by either the Chief Executive Officer or the Chief Financial officer of the
Corporation to have been so prepared, and which shall include the following:

                                       11
<PAGE>

          (a)  an income statement for such quarter, together with a cumulative
income statement from the first day of the then-current fiscal year to the last
day of such quarter;

          (b)  a balance sheet as of the last day of such quarter;

          (c)  a statement of cash flows for such quarter;

          (d)  a comparison between the actual figures for such quarter, the
comparable figures (with respect to the foregoing clauses (a) and (b) only) for
the prior year (if any) and the comparable figures included in the Budget (as
hereinafter defined) for such quarter, with an explanation of any material
differences between them.

    The financial report for each fiscal quarter shall be accompanied by a
report by the Chief Executive Officer of the Corporation explaining business
developments and problems occurring during the quarter.

    7.2   Annual Reports.  Within 120 days after the end of each fiscal year of
          --------------
the Corporation, audited financial statements of the Corporation, which shall
include an income statement for such fiscal year and a balance sheet as of the
last day thereof, and statements of stockholders' equity and cash flows for such
fiscal year, each prepared in accordance with generally accepted accounting
principles consistently applied, certified by independent certified public
accountants of recognized national standing satisfactory to the Investors,
together with such accountants' annual management letter.

    7.3   Consolidated Financial Statements.  If for any period the Corporation
          ---------------------------------
shall have any subsidiary whose accounts are consolidated with those of the
Corporation, then in respect of such period the financial statements delivered
pursuant to the foregoing Sections 7.1 and 7.2 shall be the consolidated and
consolidating financial statements of the Corporation and all such consolidated
subsidiaries.

    7.4   Other Reports and Information.  Promptly upon becoming available:
          -----------------------------

          (a)  copies of all financial statements, reports, notices, press
releases, proxy statements and other documents sent by the Corporation to its
stockholders or released to the public and copies of all regular and periodic
reports, if any, filed by the Corporation with the Commission or any securities
exchange; and

          (b)  any other financial or other information available to management
of the Corporation as any of the Investors shall have reasonably requested on a
timely basis.

    7.5   Budgets and Operating Plans.  At least 30 days prior to the beginning
          ---------------------------
of each fiscal year of the Corporation, a monthly operating plan of the
Corporation, with monthly break-downs, for such fiscal year (the "Budget"). The
Budget shall be accepted as the Budget for such fiscal year when it has been
approved by the Board of Directors of the Corporation. The Budget shall be
reviewed by the Corporation periodically and all changes therein and all
material deviations therefrom which are proposed to be made by the Corporation
shall be resubmitted to its Board of Directors in advance and shall be accepted
when approved by, and the Corporation

                                       12
<PAGE>

shall not make any such changes or material deviations to or from the Budget
without such prior approval of, its Board of Directors. The Budget shall include
an income statement, balance sheet and cash flow information.

    7.6   Limitations on Rights of Investors under Section 7.  The Corporation
          --------------------------------------------------
shall provide the information required by Sections 7.1 through 7.5 to each
Investor and any Series D Transferee so long as such Investor or Series D
Transferee shall own at least 100,000 shares of the Common Stock (including in
such number shares of Common Stock issuable upon Conversion of Series D
Preferred) appropriately adjusted to take account of any stock split, stock
dividend, combination of shares or the like. The foregoing provisions of this
Section 7 to the contrary notwithstanding, the Investors shall not have any
rights and the Corporation shall not have any obligations under the foregoing
provisions of this Section 7 at such time that the Common Stock is registered
under Section 12 of the Exchange Act.

    SECTION 8.  Additional Agreements of the Corporation.
    ---------   ----------------------------------------

    8.1   Right of First Refusal.
          ----------------------

          (a)  Subject to the limitations set forth in paragraph (i) of this
Section 8.1 and in Section 8.9, the Corporation hereby grants to each Investor,
each Series C Investor, each Series B Investor, each Founder, and any of their
respective permitted assignees described in paragraph (j) of this Section 8.1
(each a "Right Holder") the right of first refusal to purchase, pro rata, all
(or any part) of any New Securities (as defined in this Section 8.1(b)) that the
Corporation may, from time to time, propose to sell or issue. Each such Right
Holder's pro rata share, for purposes of this right of first refusal, is the
ratio of (i) the number of shares of Common Stock then held of record by, or
issuable on conversion of Series D Preferred, Series C Preferred, Series B
Preferred or Series A Preferred (collectively, "Preferred Stock") then held of
record by, such Right Holder to (ii) the sum of the total number of shares of
the Common Stock issued and outstanding plus the total number of shares of
Common Stock issuable upon conversion of the Preferred Stock, in each case at
such time (the "Basic Amount").

          (b)  "New Securities" shall mean any equity securities of the
Corporation, whether now authorized or not, and rights, options, or warrants to
purchase said equity securities, and securities of any type whatsoever that are,
or may become, convertible into said equity securities; provided, however, that
"New Securities" does not include (i) securities offered to the public pursuant
to a registration statement filed under the Securities Act, the gross proceeds
to the Corporation from the sale of which would equal or exceed $20,000,000;
(ii) securities issued pursuant to the acquisition of another corporation by the
Corporation by merger, purchase of substantially all of the assets, or other
reorganization whereby the Corporation acquires not less than a majority of the
voting power of such corporation; (iii) up to 2,700,000 shares (appropriately
adjusted to take account of any stock split, stock dividend, combination of
shares or the like) of Common Stock (or related options) issued to employees,
officers or other persons performing services for the Corporation pursuant to
any stock offering, plan or arrangement approved by the Board of Directors of
the Corporation, which number may be adjusted upward by the affirmative vote of
a majority of the whole Board of Directors; (iv) securities issued in connection
with any stock split, stock dividend or recapitalization by the Corporation; (v)
shares of Common Stock issued upon conversion of the Shares; (vi) securities
issuable upon exercise or

                                       13
<PAGE>

conversion of any rights, options, warrants or convertible securities
outstanding on the date of this Agreement; (vii) securities issued to any
financial institution in connection with a loan transaction approved by the
Board of Directors of the Corporation; (viii) securities issued to vendors or
customers or to other persons in similar commercial situations with the
Corporation, provided such issuance is approved by the Board of Directors of the
Corporation; (ix) securities issued in connection with obtaining lease
financing, whether issued to a lessor, guarantor or other person involved in the
financing, provided such issuance is approved by the Board of Directors of the
Corporation; (x) the Additional Shares; (xi) securities issued to Technologie-
Beteiligungs-Gesellschaft mbH der Deutschen Ausgleighsbank ("TBG") upon
conversion of any repayment premiums payable to TBG by the Corporation's German
subsidiary pursuant to silent partnership arrangements in the aggregate amount
of DM 6 million; or (xii) any right, option or warrant to acquire any security
convertible into securities excluded from the definition of New Securities
pursuant to clauses (i) through (x) above.

          (c)  The Corporation shall not issue, sell or exchange, agree to
issue, sell or exchange, or reserve or set aside for issuance, sale or exchange
any New Securities unless the Corporation shall deliver to each Right Holder a
written notice of any proposed or intended issuance, sale or exchange of New
Securities (the "Offer"), which Offer shall (i) identify and describe the New
Securities, (ii) describe the price and other terms upon which they are to be
issued, sold or exchanged, and the number or amount of the New Securities to be
issued, sold or exchanged, (iii) identify the persons or entities to which or
with which the New Securities are to be offered, issued, sold or exchanged and
(iv) offer to issue and sell to or exchange with such Right Holder (a) such
Right Holder's Basic Amount, and (b) any additional portion of the New
Securities as such Right Holder shall indicate it will purchase or acquire
should the other Right Holders subscribe for less than their Basic Amounts (the
"Undersubscription Amount"). Each Right Holder shall have the right, for a
period of 30 days following delivery of the Offer, to purchase or acquire, at a
price and upon the other terms specified in the Offer, the number or amount of
New Securities described above. The Offer by its terms shall remain open and
irrevocable for such 30-day period.

          (d)  To accept an Offer, in whole or in part, a Right Holder must
deliver a written notice to the Corporation prior to the end of the 30-day
period of the Offer, setting forth the portion of the Right Holder's Basic
Amount that such Right Holder elects to purchase and, if such Right Holder shall
elect to purchase all of its Basic Amount, the Undersubscription Amount (if any)
that such Right Holder elects to purchase (the "Notice of Acceptance"). If the
Basic Amounts subscribed for by all Right Holders are less than the total New
Securities, then each Right Holder who has set forth an Undersubscription Amount
in its Notice of Acceptance shall be entitled to purchase, in addition to the
Basic Amount subscribed for, the Undersubscription Amount it has subscribed for;
provided, however, that should the Undersubscription Amounts subscribed for
exceed the difference between the New Securities and the Basic Amounts
subscribed for (the "Available Undersubscription Amount"), each Right Holder who
has subscribed for any Undersubscription Amount shall be entitled to purchase
only that portion of the Available Undersubscription Amount as the
Undersubscription Amount subscribed for by such Right Holder bears to the total
Undersubscription Amounts subscribed for by all Right Holders, subject to
rounding by the Board of Directors to the extent it reasonably deems necessary.

                                       14
<PAGE>

          (e)  In the event that Notices of Acceptance are not given by the
Right Holders in respect of all the New Securities, the Corporation shall have
90 days from the expiration of the period set forth in paragraph (c) above to
issue, sell or exchange all or any part of such New Securities as to which a
Notice of Acceptance has not been given by the Right Holders (the "Refused
Securities"), but only to the offerees or purchasers and only upon terms and
conditions (including, without limitation, unit prices and interest rates) which
are described in the Offer.

          (f)  In the event the Corporation shall propose to sell less than all
the Refused Securities (any such sale to be in the manner and on the terms
specified in paragraph (e) above), then each Right Holder may, at its sole
option and in its sole discretion, reduce the number or amount of the New
Securities specified in its Notice of Acceptance to an amount that shall be not
less than the number or amount of the New Securities that the Right Holder
elected to purchase pursuant to paragraph (d) above multiplied by a fraction,
(i) the numerator of which shall be the number or amount of New Securities the
Corporation actually proposes to issue, sell or exchange (including New
Securities to be issued or sold to Right Holders pursuant to paragraph (d) above
prior to such reduction) and (ii) the denominator of which shall be the amount
of all New Securities. In the event that any Right Holder so elects to reduce
the number or amount of New Securities specified in its Notice of Acceptance,
the Corporation may not issue, sell or exchange more than the reduced number or
amount of the New Securities unless and until such securities have again been
offered to the Right Holders in accordance with paragraph (c) above.

          (g)  Upon the closing of the issuance, sale or exchange of all or less
than all the Refused Securities, the Right Holders shall acquire from the
Corporation, and the Corporation shall issue to the Right Holders, the number or
amount of New Securities specified in the Notices of Acceptance, as reduced
pursuant to paragraph (f) above if the Right Holders have so elected, upon the
terms and conditions specified in the Offer. The purchase by the Right Holders
of any New Securities is subject in all cases to the preparation, execution and
delivery by the Corporation and the Right Holders of a purchase agreement
relating to such New Securities reasonably satisfactory in form and substance to
the Right Holders and their respective counsel.

          (h)  Any New Securities not acquired by the Right Holders or other
persons in accordance with paragraph (e) above may not be issued, sold or
exchanged until they are again offered to the Right Holders under the procedures
specified in this Agreement.

          (i)  This right of first refusal shall run to each Investor, each
Series C Investor, each Series B Investor, each Founder and any of their
respective permitted assignees under paragraph (j) of this Section 8.1 only for
so long as they hold the following number of shares of Common Stock (including
in such number shares of Common Stock issuable upon conversion of Preferred
Stock):

               (i)   in the case of the Founders and the Series B Investors who
were parties to the Stock Purchase Agreement dated May 26, 1994, and their
respective permitted assignees, 50,000 shares; and

                                       15
<PAGE>

               (ii)  in the case of all other Series B Investors, the Series C
Investors and the Investors, and their respective permitted assignees, 200,000
shares (including shares held by their respective Affiliates (as hereinafter
defined)).

          (j)  This right of first refusal may be assigned, in whole or in part,
(i) to any Affiliate (as hereinafter defined) of any Right Holder or (ii) to any
assignee who acquires not less than 50,000 shares of Common Stock in the case of
an assignment from assignor described in clause (i) of paragraph (i) of this
Section 8.1, or 200,000 shares of Common Stock in the case of an assignment from
an assignor described in clause (ii) of paragraph (i) of this Section 8.1 (in
each case, including in such number shares of Common Stock issuable upon
conversion of Preferred Stock and appropriately adjusted to take account of any
stock split, stock dividend, combination of shares, or the like). As used in
this Section, an Affiliate of a Right Holder shall mean any general or limited
partner of the Right Holder that is a partnership or any person or entity that,
directly or indirectly, through one or more intermediaries, controls, or is
controlled by, or is under common control with, the Right Holder. In addition,
for purposes of this Section, in the case of any Right Holder that is a limited
partnership for which TVM Techno Venture Management Limited Partnership, TVM
Techno Venture Management III GmbH or any of their respective Affiliates serves
as a general partner, the term Affiliate of any such Right Holder shall include
KBL Founder Ventures SCA, KB Lux Venture Capital Fund - European Biotechnology
and their respective Affiliates and Alpinvest International B.V. and its
Affiliates.

          (k)  This Section 8.1 shall amend and restate Section 8.1 of the
Series C Purchase Agreement, which Section 8.1 shall no longer have any force or
effect.

    8.2   Keeping of Records and Books of Account.  The Corporation shall keep,
          ---------------------------------------
and cause each subsidiary to keep, adequate records and books of account, in
which complete entries will be made in accordance with generally accepted
accounting principles consistently applied, reflecting all financial
transactions of the Corporation and such subsidiary, and in which, for each
fiscal year, all proper reserves for depreciation, depletion, obsolescence,
amortization, taxes, bad debts and other purposes in connection with its
business shall be made.

    8.3   Insurance.  The Corporation will do or cause to be done all things
          ---------
necessary to preserve and maintain in full force and effect fire and casualty
insurance policies, with extended coverage, on its properties, assets, business
and personnel, in amounts deemed adequate by the Corporation, and in accordance
with the standards of the industry in which the Corporation operates, sufficient
in amount to allow it to replace any of its properties which might be damaged or
destroyed.

    8.4   Key Man Life Insurance.  The Corporation shall use its best efforts to
          ----------------------
maintain in force a policy of life insurance, naming the Corporation as
beneficiary, on the life of Dr. Hubert Koster, in the amount of US$1,000,000.

    8.5   Maintenance of Corporate Existence, etc.  The Corporation will do or
          ---------------------------------------
cause to be done all reasonable things necessary to preserve and keep in full
force and effect its existence and all of its rights (charter and statutory),
subject in all cases to the exercise by the Board of Directors of the
Corporation of their fiduciary obligations. The Corporation shall comply in all
respects with the provisions of its Certificate of Incorporation and By-laws.

                                       16
<PAGE>

    8.6   Maintenance of Facilities.  The Corporation will cause all facilities
          -------------------------
owned or leased in the conduct of its business to be maintained and kept in good
condition and repair and will cause to be made all necessary repairs, renewals,
replacements, betterments and improvements thereof, all as in the judgment of
the Corporation may be necessary so that the business carried on in connection
therewith may be properly and advantageously conducted at all times; provided,
however, that nothing in this Section shall prevent the Corporation from
discontinuing the lease or maintenance of any such facilities if such
discontinuance is, in the good faith judgment of the Board of Directors of the
Corporation, desirable in the conduct of its business.

    8.7   Payment of Taxes.  The Corporation will pay or discharge or cause to
          ----------------
be paid or discharged, before the same shall become delinquent, (1) all material
taxes, assessments and governmental charges levied or imposed upon the
Corporation or upon the income, profits or property of the Corporation; and (2)
all material liabilities of the Corporation; provided, however, that the
Corporation shall not be required to pay or discharge or cause to be paid or
discharged any such tax assessment, liability, or charge, whose amount,
applicability or validity is being contested in good faith by appropriate
proceedings if adequate reserves therefor have been established in accordance
with generally accepted accounting principles.

    8.8   Compliance with Applicable Laws.  The Corporation shall conduct its
          -------------------------------
business in compliance in all material respects with all laws and valid
requirements of governmental authorities relating to the conduct of its business
or to its properties or assets.

    8.9   Limitation On Rights of Investors.  The rights of Right Holders,
          ---------------------------------
including the Investors under Section 8.1, and the obligations of the
Corporation to Right Holders, including the Investors under Section 8.1, shall
terminate and be of no effect upon and following the closing of a firm
commitment underwritten public offering of the Corporation's Common Stock
pursuant to an effective registration statement under the Securities Act in
which (i) the offering price per share is not less than $10.00 (prior to
underwriter's discounts and commissions), appropriately adjusted to take account
of any stock split, stock dividend, combination of shares, or the like, and (ii)
the aggregate gross proceeds to the Corporation from such offering are not less
than $20 million.

    8.10  Proprietary Information and Invention Assignment Agreements.  As soon
          -----------------------------------------------------------
as practicable after the Initial Closing, the Corporation will use reasonable
efforts to cause each senior technical employee who has not already signed an
agreement with the Corporation relating to the protection of proprietary
information and the assignment of inventions to sign such an agreement in a form
acceptable to the Board of Directors of the Corporation.

    SECTION 9.  Expenses.
    ----------  --------

    9.1   Expenses.  The Corporation shall pay the reasonable fees and
          --------
disbursements of one or more special counsel to the Investors in connection with
the transactions contemplated by this Agreement, up to a maximum aggregate
amount of $10,000. Otherwise, the Corporation and the Investors shall each bear
their own expenses, including the fees and disbursements of their respective
counsel, incurred in connection with the purchase and sale of the Shares.

                                       17
<PAGE>

    9.2   Brokers.  No party to this Agreement has employed any broker or finder
          -------
in connection with the transactions contemplated hereby. No person or entity
will have, as a result of the transactions contemplated by this Agreement, any
right, interest or valid claim against or upon any such party of any commission,
fee or other compensation as a finder or broker because of any act or omission
by such party or any agent of such party. Each party to this Agreement agrees to
indemnify and hold the others harmless from payment of any brokerage fee,
finders fee, or commission claimed by any third party who claims to have been
involved because of association with such party.

    SECTION 10.   Exchanges; Lost, Stolen or Mutilated Certificates. Upon
    -----------   -------------------------------------------------
surrender by any Investor to the Corporation of a certificate or certificates
representing shares of Series D Preferred purchased or acquired by such Investor
hereunder, or representing Reserved Shares received upon conversion of any such
shares of Series D Preferred, the Corporation at its expense shall issue in
exchange therefor, and deliver to such Investor, a new certificate or
certificates representing such shares, in such denomination or denominations as
may be requested by such Investor. Upon receipt of evidence satisfactory to the
Corporation of the loss, theft, destruction or mutilation of any certificate
representing any shares of Series D Preferred purchased or acquired by the
Investor hereunder, or representing Reserved Shares received upon conversion of
any such shares of Series D Preferred and in case of any such loss, theft or
destruction, upon delivery of any indemnity agreement satisfactory to the
Corporation, or in case of any such mutilation, upon surrender and cancellation
of such certificate, the Corporation at its expense shall issue and deliver to
such Investor a new certificate for such shares of Series D Preferred or
Reserved Shares, of like tenor, in lieu of such lost, stolen or mutilated
certificate.

    SECTION 11.   Survival of Representations, Warranties, Covenants and
    -----------   ------------------------------------------------------
Agreements.  The covenants, representations and warranties of the parties
- ----------
contained herein shall survive the execution and delivery of this Agreement, the
Initial Closing and all Additional Closings. Each of the parties may rely on
such covenants, representations and warranties irrespective of any investigation
made, or notice or knowledge held by, it or any other person. All statements
contained in any certificate or other instrument delivered by any party pursuant
to this Agreement or in connection with the transactions contemplated by this
Agreement shall constitute representations and warranties by such party under
this Agreement.

    SECTION 12.   Remedies.  In case any one or more of the covenants or
    -----------   --------
agreements set forth in this Agreement shall have been breached by the
Corporation, the Investors may proceed to protect and enforce their rights
either by suit in equity or by action at law, including, but not limited to, an
action for damages as a result of any such breach or an action for specific
performance of any such covenant or agreement contained in this Agreement.

    SECTION 13.   Successors and Assigns.  This Agreement shall be binding upon,
    -----------   ----------------------
and inure to the benefit of, each of the parties hereto and, except as otherwise
expressly provided herein, each other person who shall become a registered
holder named in any certificate evidencing shares of Common Stock or Series D
Preferred transferred to such holder by any of the Investors or their permitted
transferees, and (except as aforesaid) their respective legal representatives,
successors and assigns.

                                       18
<PAGE>

    SECTION 14.   Entire Agreement; Effect on Prior Documents.  This Agreement
    -----------   -------------------------------------------
and the other documents referred to herein or delivered pursuant hereto contain
the entire agreement among the parties with respect to the financing
transactions contemplated hereby and supersede all prior negotiations,
commitments, agreements and understandings among them with respect thereto.

    SECTION 15.   Notices.  All notices, requests, consents and other
    -----------   -------
communications hereunder to any party shall be deemed to be sufficient if
contained in a written instrument delivered in person or duly sent by first
class mail postage prepaid (other than to non-U.S. parties) or fax or DHL,
Federal Express or other internationally recognized express courier service,
addressed to such party at the address set forth below or such other address as
may hereafter be designated in writing by the addressee to the addressor listing
all parties:

                  (i)  if to the Corporation, to:

                       Sequenom, Inc.
                       11555 Sorrento Valley Road, Suite C
                       San Diego, California 92121
                       Attention: President
                       Fax: (619) 350-0344

                       with a copy to:

                       John A. Denniston, Esq.
                       Brobeck, Phleger & Harrison LLP
                       550 West C Street, Suite 1300
                       San Diego, California 92101
                       Fax: (619) 234-3848

                 (ii)  if to the Investors, to their respective addresses set
forth on the Schedule of Investors.
             ---------------------

    SECTION 16.   Amendments; Waivers.  This Agreement, other than Sections 8.1
    -----------   -------------------
and 8.9 and the second sentence of this Section 16, may be amended, and
compliance with the provisions of this Agreement, other than Sections 8.1 and
8.9 and the second sentence of this Section 16, may be omitted or waived, by the
written agreement of the Corporation and Investors or assignees of their rights
hereunder holding at least two-thirds in voting power of the Series D Preferred
(and Common Stock issued upon conversion thereof) held by the Investors and such
assignees. Sections 8.1 and 8.9 hereof and the second sentence of this Section
16 may be amended, and compliance with the provisions of Sections 8.1 and 8.9
hereof and the second sentence of this Section 16 may be omitted or waived, by
the written agreement of the holders of at least two-thirds in voting power of
the Series A Preferred, Series B Preferred, Series C Preferred and Series D
Preferred (or Common Stock issued upon conversion thereof) held by Right
Holders.

    SECTION 17.   Counterparts.  This Agreement may be executed in any number of
    -----------   ------------
counterparts, each such counterpart shall be deemed to be an original
instrument, and all such

                                       19
<PAGE>

counterparts together shall constitute but one agreement. Any such counterpart
may contain one or more signature pages.

    SECTION 18.   Headings.  The headings of the various sections of this
    -----------   --------
Agreement have been inserted for convenience of reference only and shall not be
deemed to be a part of this Agreement.

    SECTION 19.   Nouns and Pronouns.  Whenever the context may require, any
    -----------   ------------------
pronouns used herein shall include the corresponding masculine, feminine or
neuter forms, and the singular form of names and pronouns shall include the
plural and vice-versa.

    SECTION 20.   Governing Law.  This Agreement shall be governed by, and
    -----------   -------------
construed and enforced in accordance with, the substantive laws of the State of
California, without regard to its principles of conflicts of laws.

    SECTION 21.   Severability.  Any provision of this Agreement that is
    -----------   ------------
prohibited or unenforceable in any jurisdiction shall, as to such jurisdiction,
be ineffective to the extent of such prohibition or unenforceability without
invalidating the remaining provisions hereof, and any such prohibition or
unenforceability in any jurisdiction shall not invalidate or render
unenforceable such provision in any other jurisdiction.

    SECTION 22.   Information Confidential.  Each Investor acknowledges that the
    -----------   ------------------------
information received by it pursuant hereto (including without limitation under
Section 7 hereof) is confidential and for its use only and such Investor will
not reproduce, disclose or disseminate such information to any other person
(other than its employees or agents having a need to know the contents of such
information), except in connection with the exercise of rights under this
Agreement, unless the Corporation has made such information available to the
public generally or such Investor is required to disclose such information by
law or by any court or other governmental body; provided, however, that an
Investor may make general statements concerning the nature and progress of the
Corporation's business and may include summary financial information concerning
the Corporation in such Investor's reports to its partners or shareholders. The
obligation of confidentiality set forth in this Section shall not apply to
information (i) generally known on a non-confidential basis (without fault of an
Investor) to companies in the Corporation's line of business; (ii) lawfully
obtained by an Investor without restriction on disclosure; (iii) known to an
Investor prior to receipt from the Corporation without restriction on
disclosure; or (iv) independently developed by an Investor without use of
information provided by the Corporation.


                                    *  *  *

                                       20
<PAGE>

    IN WITNESS WHEREOF, the undersigned have executed this Series D Convertible
Preferred Stock Purchase Agreement as of the day and year first written above.


                              SEQUENOM, INC.

                              By:   /s/ Hubert Koster
                                    ----------------------------------
                              Its:  President

FOUNDERS:

                              /s/ Hubert Koster
                              ----------------------------------------
                              Hubert Koster

                              /s/ Nola E. Masterson
                              ----------------------------------------
                              Nola E. Masterson

                              /s/ Robert E. Patterson
                              ----------------------------------------
                              Robert E. Patterson

SERIES B INVESTORS:

                              TVM TECHNO VENTURE
                              ENTERPRISES NO. II
                              LIMITED PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner

                              By:   TVM Management LLC
                                      its General Partner

                              By:   /s/ illegible
                                    ----------------------------------
                              Its:  Treasurer
                                    ----------------------------------
<PAGE>

                              TVM INTERTECH LIMITED PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner

                              By:   TVM Management LLC
                                      its General Partner

                              By:   /s/ illegible
                                    ----------------------------------
                              Its:  Treasurer
                                    ----------------------------------


                              TVM ZWEITE BETEILIGUNG-US
                              LIMITED PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner

                              By:   TVM Management LLC
                                      its General Partner

                              By:   /s/ illegible
                                    ----------------------------------
                              Its:  Treasurer
                                    ----------------------------------


                              TVM EUROTECH LIMITED PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner

                              By:   TVM Management LLC
                                      its General Partner

                              By:   /s/ illegible
                                    ----------------------------------
                              Its:  Treasurer
                                    ----------------------------------


  [SIGNATURE PAGE TO SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]
<PAGE>

                              TVM TECHNO VENTURE INVESTORS NO. I
                              LIMITED PARTNERSHIP

                              By:   /s/ illegible
                                    ----------------------------------
                                    General Partner


                              ***

                              By:   ***               ***
                                    ---------------   ----------------
                              Its:  ***               ***
                                    ---------------   ----------------


                              ALPINVEST INTERNATIONAL B.V.

                              By:   /s/ illegible     /s/ illegible
                                    ---------------   ----------------
                              Its:  authorized signatories
                                    ----------------------------------


                              ***


                              By:   ----------------------------------
                                    ***



                                    ----------------------------------
                                    ***



                                    ----------------------------------
                                    ***


                                    ***
                                    ----------------------------------
                                    ***


                                    ----------------------------------
                                    ***

   [SIGNATURE PAGE TO SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                    ----------------------------------
                                    ***


                                    ----------------------------------
                                    ***

                                    /s/ Hubert Koster
                                    ----------------------------------
                                    Hubert Koster

                                    /s/ Ernst-Gunter Afting
                                    ----------------------------------
                                    Ernst-Gunter Afting


                                    ***


                                    By:   ***


                                    By:   ***
                                          ----------------------------
                                          ***


                                    ***

                                    By:   ***


                                    By:   ***
                                          ----------------------------
                                          ***

  [SIGNATURE PAGE TO SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                    ***

                                    By:   ***
                                          ***

                                    By:   ***
                                          ----------------------------
                                          ***

SERIES C INVESTORS:

                                    TVM TECHNO VENTURE
                                    ENTERPRISES NO. II
                                    LIMITED PARTNERSHIP


                                    By:   TVM Techno Venture Management
                                          Limited Partnership
                                             its general partner


                                    By:   TVM Management LLC
                                             its general partner


                                    By:   /s/ illegible
                                          ----------------------------
                                    Its:  Treasurer
                                          ----------------------------


                                    TVM INTERTECH
                                    LIMITED PARTNERSHIP


                                    By:   TVM Techno Venture Management
                                          Limited Partnership
                                            its general partner


                                    By:   TVM Management LLC
                                            its general partner


                                    By:   /s/ illegible
                                       ----------------------------------
                                    Its:  Treasurer
                                       ----------------------------------

  [SIGNATURE PAGE TO SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                              TVM ZWEITE BETEILIGUNG-US
                              LIMITED PARTNERSHIP


                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its general partner


                              By:   TVM Management LLC
                                      its general partner


                              By:   /s/ illegible
                                    ----------------------------------
                              Its:  Treasurer
                                    ----------------------------------


                              TVM EUROTECH
                              LIMITED PARTNERSHIP


                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its general partner


                              By:   TVM Management LLC
                                      its general partner


                              By:   /s/ illegible
                                    ----------------------------------
                              Its:  Treasurer
                                    ----------------------------------


                              TVM TECHNO VENTURE INVESTORS NO. I
                              LIMITED PARTNERSHIP


                              By:   /s/ illegible
                                    ----------------------------------
                              Its:  Treasurer
                                    ----------------------------------


                              ***


                              By:   ***                  ***
                                    -------------        -------------
                              Its:  ***                  ***
                                    -------------        -------------

  [SIGNATURE PAGE TO SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                              ALPINVEST INTERNATIONAL B.V.


                              By:   /s/ illegible        /s/ illegible
                                    -------------        -------------
                              Its:  authorized signatories
                                    ----------------------------------


                              ***
                              -----------------------------------------
                              ***



                              ***
                              ----------------------------------------
                              ***


                              ----------------------------------------
                              ***


                              ----------------------------------------
                              ***


                              ***


                              By:   ***
                                    ----------------------------------
                              Its:  ***
                                    ----------------------------------
                                    ***


                              ***


                              By:   ***
                                    ----------------------------------
                              Its:  ***
                                    ----------------------------------


                              LOMBARD ODIER & CIE


                              By:   /s/ Michaela Troyanov     /s/ A. Plattet
                                    ------------------------  --------------
                              Its:  Assistant Vice President  Vice President
                                    ------------------------  --------------

  [SIGNATURE PAGE TO SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]



***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                              ***


                              By:
                                    ----------------------------------
                              Its:
                                    ----------------------------------


                              ***


                              By:   ***
                                    ----------------------------------
                              Its:  ***
                                    ----------------------------------


                              ***


                              By:   ***

                              Its:  ***


                              By:   ***
                                    ----------------------------------
                              Its:
                                    ----------------------------------


                              ***


                              By:   ***


                              Its:  ***


                              By:   ***
                                    ----------------------------------
                              Its:
                                    ----------------------------------
  [SIGNATURE PAGE TO SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]



***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                              ***


                              By:   ***


                              Its:  ***


                              By:   ***
                                    ----------------------------------
                              Its:
                                    ----------------------------------



                              ***


                              By:   ***              ***
                                    ---------------  -------------------------
                              Its:  ***              ***
                                    ---------------  -------------------------

  [SIGNATURE PAGE TO SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]



***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    EXECUTED this 21st day of December, 1998.


                              ***
                              ----------------------------------------
                              (print name)

461,538                       By: ***
- ----------------                  ------------------------------------
Shares Purchased

                              Title:  ***
                                      --------------------------------


                              Address:
$3,000,000                             -------------------------------
- --------------------
Total Purchase Price          ----------------------------------------
                              ----------------------------------------


                     [INITIAL INVESTOR SIGNATURE PAGE TO
           SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    EXECUTED this 21st day of December, 1998.


                              ***
                              ----------------------------------------
                              (print name)

652,686                       By: ***
- ----------------                  ------------------------------------
Shares Purchased

                              Title:  ***
                                      --------------------------------

                              By:   ***
                                    ----------------------------------


                              Title:  ***
                                      --------------------------------


                              Address: ***
                                      --------------------------------
US $4,242,459.00              ***
- --------------------          ----------------------------------------
Total Purchase Price          ***
                              ----------------------------------------


                     [INITIAL INVESTOR SIGNATURE PAGE TO
           SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    EXECUTED this 21st day of December, 1998.


                              ***
                              ----------------------------------------
                              (print name)

                              By:  ***
- -----------------------            -----------------------------------
Shares Purchased

                              Title:  ***
                                      --------------------------------


                              Address: ***
                                       -------------------------------
$3,000,000                    ***
- -----------------------       ----------------------------------------
Total Purchase Price          ***
                              ----------------------------------------

                     [INITIAL INVESTOR SIGNATURE PAGE TO
           SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    EXECUTED this 21st day of December, 1998.


                              ***
                              ----------------------------------------
                              (print name)

84,000                        By: ***
- -------------------------         ------------------------------------
Shares Purchased

                              Title:  ***
                                      --------------------------------



                              Address: ***
                                       -------------------------------
USD 546,000                     ***
- -------------------------       --------------------------------------
Total Purchase Price            ***
                                --------------------------------------


                     [INITIAL INVESTOR SIGNATURE PAGE TO
           SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    EXECUTED this 21st day of December, 1998.


                              ***
                              ----------------------------------------
                              (print name)

172,000                       By: ***
- -------------------------         ------------------------------------
Shares Purchased

                              Title:  ***
                                      --------------------------------


                              Address: ***
                                       -------------------------------
$1,118,000.00                 ***
- --------------------          ----------------------------------------
Total Purchase Price          ***
                              ----------------------------------------


                     [INITIAL INVESTOR SIGNATURE PAGE TO
           SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    EXECUTED this 21st day of December, 1998.


                              ***
                              ----------------------------------------
                              (print name)

                              By:  ***
- -------------------------          -----------------------------------
Shares Purchased

                              Title:
                                     ---------------------------------


                              Address: ***
                                       -------------------------------
100,000                       ***
- -------------------------     ----------------------------------------
Total Purchase Price          ***
                              ----------------------------------------


                     [INITIAL INVESTOR SIGNATURE PAGE TO
           SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                 SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    EXECUTED this 21st day of December, 1998.


                              ***
                              ----------------------------------------
                              (print name)

20,000                        By: ***
- -------------------------     ----------------------------------------
Shares Purchased

                              Title:  ***
                                      --------------------------------


                              Address: ***
                                       -------------------------------
US $130,000                   ***
- -------------------------     ----------------------------------------
Total Purchase Price          ***
                              ----------------------------------------



                     [INITIAL INVESTOR SIGNATURE PAGE TO
           SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    EXECUTED this 21st day of December, 1998.

                              ***
                              --------------------------------------------
                              (print name)

461,538                       By: ***                ***
- -------------------------         -----------------  ---------------------
Shares Purchased                  ***                ***

                              Title:  ***           / ***
                                      -------------------------------------



                              Address: ***
                                       ------------------------------------
USD 2,999,997.00              ***
- -------------------------     ---------------------------------------------
Total Purchase Price          ***
                              ---------------------------------------------

We refer to the Memorandum dated November 16, 1998
and the documents in the drafting dated November 11, 1998



                     [INITIAL INVESTOR SIGNATURE PAGE TO
           SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    EXECUTED this 21st day of December, 1998.


                              Prof. Dr. med. Dr. rer. Nat.
                              Ernst-Gunter Afting
                              ----------------------------------------
                              (print name)

                              By:  /s/ Ernst- Gunter Afting
- -------------------------          -----------------------------------
Shares Purchased

                              Title:
                                     ---------------------------------

                              Address:
                                      --------------------------------

- -------------------------     ----------------------------------------
Total Purchase Price
                              ----------------------------------------


                     [INITIAL INVESTOR SIGNATURE PAGE TO
           SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    EXECUTED this 21st day of December, 1998.


                              ***
                              ----------------------------------------
                              (print name)

38,461                        By: ***
- -------------------------     ----------------------------------------
Shares Purchased

                              Title:  ***
                                      --------------------------------


                              Address: ***
                                       -------------------------------
$269,966.50                            ***
- -------------------------     ----------------------------------------
Total Purchase Price                   ***
                              ----------------------------------------


                     [INITIAL INVESTOR SIGNATURE PAGE TO
           SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]


*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    EXECUTED this 21st day of December, 1998.


                              Alpinvest International B.V.
                              ----------------------------------------
                              (print name)

461,538                       By: /s/ illegible          /s/ illegible
- -------------------------         --------------         -------------
Shares Purchased

                              Title:  Authorized Signatories
                                      --------------------------------


                              Address: Gooimeer 3, P.O. Box 5073
                                       -------------------------------
US 2,999,997.00               1410 AB Naarden
- -------------------------     ----------------------------------------
Total Purchase Price          The Netherlands
                              ----------------------------------------


                     [INITIAL INVESTOR SIGNATURE PAGE TO
           SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    EXECUTED this 21st day of December, 1998.


                              ***


136,616                       By: ***                 ***
- -------------------------         -------------       --------------
Shares Purchased              Its:  ***               ***
                                    -----------        ---------------


                              Address: ***
                                       -------------------------------
$888,004                               ***
- -------------------------     ----------------------------------------
Total Purchase Price                   ***
                              ----------------------------------------


                     [INITIAL INVESTOR SIGNATURE PAGE TO
           SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]




***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    EXECUTED this 21st day of December, 1998.


                              ***


136,615                       By: ***                  ***
- -------------------------         -------------        -------------
Shares Purchased              Its:  ***                ***
                                    -----------        -------------


                              Address: ***
                                       -------------------------------
$887,998                               ***
- -------------------------     ----------------------------------------
Total Purchase Price                   ***
                              ----------------------------------------

                     [INITIAL INVESTOR SIGNATURE PAGE TO
           SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]



***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

     By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    EXECUTED this 21st day of December, 1998.


                              TVM MEDICAL VENTURES


                              By:   /s/ illegible         /s/ illegible
- -------------------------           -------------         -------------
Shares Purchased              Its:    Managing Partner    CFO
                                      --------------------------------


                              Address:
$ 3,500,000                            -------------------------------
- -------------------------     ----------------------------------------
Total Purchase Price          ----------------------------------------


                     [INITIAL INVESTOR SIGNATURE PAGE TO
           SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    EXECUTED this 21st day of December, 1998.


                                        TVM ZWEITE BETEILIGUNG-US
                                        LIMITED PARTNERSHIP

122,462                                 By:
- ---------------------------                 ---------------------------
Shares Purchased

                                        Title:
                                               ------------------------


                                        Address:
$796,003                                         ----------------------
- ---------------------------             -------------------------------
Total Purchase Price                    -------------------------------


                                        TVM ZWEITE BETEILIGUNG-US
                                        LIMITED PARTNERSHIP

                                        By:  TVM Techno Venture Management
                                             Limited Partnership,
                                               its General Partner

                                        By:  TVM Management, LLC
                                               its General Partner

                                        By:  /s/ illegible
                                        -------------------------------
                                        Title:   Treasurer


                     [INITIAL INVESTOR SIGNATURE PAGE TO
           SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    EXECUTED this 21st day of December, 1998.


                                        TVM TECHNO VENTURE
                                        INVESTORS NO. 1
                                        LIMITED PARTNERSHIP

4,615                                   By: /s/ illegible
- --------------------------              ----------------------------
Shares Purchased

                                        Title:  General Partner
                                                --------------------


                                        Address:
$29,997.50                                      ---------------------
- --------------------------              -----------------------------
Total Purchase Price                    -----------------------------


                     [INITIAL INVESTOR SIGNATURE PAGE TO
           SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    EXECUTED this 21st day of December, 1998.


                                        TVM INTERTECH
                                        LIMITED PARTNERSHIP

24,492                                  By:
- -----------------------------              -----------------------------
Shares Purchased

                                        Title:
                                               -------------------------


                                        Address:
$ 159,198                                        -----------------------
- -----------------------------           --------------------------------
Total Purchase Price                    --------------------------------


                                        TVM INTERTECH LIMITED PARTNERSHIP

                                        By:  TVM Techno Venture Management
                                             Limited Partnership,
                                               its General Partner

                                        By:  TVM Management, LLC
                                               its General Partner

                                        By:  /s/ illegible
                                             ---------------------------
                                        Title:   Treasurer


                     [INITIAL INVESTOR SIGNATURE PAGE TO
           SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                        Initial Investor Signature Page
                        -------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    EXECUTED this 21st day of December, 1998.


                                        TVM TECHNO VENTURE
                                        ENTERPRISES NO. II
                                        LIMITED PARTNERSHIP


36,738                                  By:
- -----------------------------               -----------------------------
Shares Purchased

                                        Title:
                                               --------------------------

                                        Address:
$238,797                                         ------------------------
- -----------------------------           ---------------------------------
Total Purchase Price


                                        TVM TECHNO VENTURE ENTERPRISES
                                        NO. II LIMITED PARTNERSHIP

                                        By:  TVM Techno Venture Management
                                             Limited Partnership,
                                               its General Partner

                                        By:  TVM Management, LLC
                                               its General Partner

                                        By:  /s/ illegible
                                             ----------------------------
                                        Title:   Treasurer

                     [INITIAL INVESTOR SIGNATURE PAGE TO
           SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT]
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    Attached hereto is an addendum to the Schedule of Investors to the Purchase
                                           ---------------------
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series D Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

    EXECUTED this 23 day of February, 1999.
                  --        --------



                           ***
                           --------------------------------------------------
                           (print name)
                           ***

                           By:   ***
                                 ---------------------------------------------
                           Title: ***
                                  --------------------------------------------
                           Address: ***
                                   -------------------------------------------
                                   ***
                                   -------------------------------------------
                                   ***
                                   -------------------------------------------

                     ADDITIONAL INVESTOR SIGNATURE PAGE TO
            SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT



***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    Attached hereto is an addendum to the Schedule of Investors to the Purchase
                                          ---------------------
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series D Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

    EXECUTED this ____ day of __________, 1999.


                              ***
                              -------------------------------------------
                              (print name)


                              By:   ***
                                    -------------------------------------
                              Title:  ***
                                     ------------------------------------
                              Address:
                                      -----------------------------------
                              -------------------------------------------
                              -------------------------------------------

                     ADDITIONAL INVESTOR SIGNATURE PAGE TO
            SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT



***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    Attached hereto is an addendum to the Schedule of Investors to the Purchase
                                          ---------------------
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series D Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

    EXECUTED this 13 day of Jan, 1999.
                  --        ---


                              ***
                              ------------------------------
                              (print name)


                              By:   ***
                                    ------------------------
                              Title:   ***
                                    ------------------------
                              Address: ***
                                      ----------------------
                                       ***
                                      ----------------------

                     ADDITIONAL INVESTOR SIGNATURE PAGE TO
            SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT



***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    Attached hereto is an addendum to the Schedule of Investors to the Purchase
                                          ---------------------
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series D Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

    EXECUTED this 19 day of Jan, 1999.
                  --        ----



                              ***
                              --------------------------------------------
                              (print name)   ***


                              By:   ***
                                    --------------------------------------
                              Title:  ***
                                    --------------------------------------
                              Address: ***
                                      ------------------------------------
                                      ***
                                      ------------------------------------
                                      ***
                                      ------------------------------------

                     ADDITIONAL INVESTOR SIGNATURE PAGE TO
            SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT



***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    Attached hereto is an addendum to the Schedule of Investors to the Purchase
                                          ---------------------
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series D Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

    EXECUTED this 22nd day of Feb., 1999.
                  --          ---


                              ***
                              -------------------------------------
                              (print name)


                              By:   ***
                                    ------------------------------
                              Title:  ***
                                    ------------------------------
                              Address:  ***
                                      ----------------------------
                                      ***
                                      -----------------------------


                     ADDITIONAL INVESTOR SIGNATURE PAGE TO
            SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT



***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    Attached hereto is an addendum to the Schedule of Investors to the Purchase
                                          ---------------------
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series D Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

    EXECUTED this 19th day of Feb, 1999.
                  ----        ---


                              ***
                              ------------------------------------
                              (print name)


                              By:   ***
                                    ------------------------------
                              Title:  ***
                                    ------------------------------
                              Address:  ***
                                      ----------------------------
                                      ***
                                      ----------------------------

                     ADDITIONAL INVESTOR SIGNATURE PAGE TO
            SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT



***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    Attached hereto is an addendum to the Schedule of Investors to the Purchase
                                          ---------------------
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series D Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

    EXECUTED this 28 day of February, 1999.
                  --        ---------


                              ***
                              ------------------------------------------
                              (print name)


                              By:   ***                 ***
                                    ------------------  -----------------
                              Title:  ***               ***
                                    -------------------------------------
                              Address:  ***
                                      -----------------------------------
                                      ***
                                      -----------------------------------


                     ADDITIONAL INVESTOR SIGNATURE PAGE TO
            SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT



***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    Attached hereto is an addendum to the Schedule of Investors to the Purchase
                                          ---------------------
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series D Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

    EXECUTED this 24 day of Feb, 1999.
                  --        ----


                              ***
                              --------------------------------
                              (print name)


                              By:   ***
                                    --------------------------
                              Title:
                                    --------------------------
                              Address:
                                      ------------------------
                              --------------------------------
                              --------------------------------

                     ADDITIONAL INVESTOR SIGNATURE PAGE TO
            SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT



***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    Attached hereto is an addendum to the Schedule of Investors to the Purchase
                                          ---------------------
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series D Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

    EXECUTED this ____ day of __________, 1999.


                              ***
                              ---------------------------------
                              (print name)


                              By:   ***
                                    ---------------------------
                              Title:
                                    ---------------------------
                              Address:  ***
                                      -------------------------
                                      ***
                                      -------------------------

                     ADDITIONAL INVESTOR SIGNATURE PAGE TO
            SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT



***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                SEQUENOM, INC.

            Series D Convertible Preferred Stock Purchase Agreement

                      Additional Investor Signature Page
                      ----------------------------------

    By executing this page in the space provided, the undersigned investor
hereby agrees (i) that it is an "Additional Investor" as defined in the Series D
Convertible Preferred Stock Purchase Agreement dated as of December 21, 1998,
among Sequenom, Inc. (the "Corporation") and certain investors named on the
Schedule of Investors thereto (the "Purchase Agreement"), (ii) that it is a
- ---------------------
party to the Purchase Agreement for all purposes and (iii) that it is bound by
all terms and conditions of the Purchase Agreement.

    Attached hereto is an addendum to the Schedule of Investors to the Purchase
                                          ---------------------
Agreement, setting forth the name of the undersigned and the number of shares of
the Corporation's Series D Convertible Preferred Stock purchased by it pursuant
to the Purchase Agreement.

    EXECUTED this 29 day of March, 1999.
                  --        ------


                              ***
                              -------------------------------------
                              (print name)


                              By:   ***
                                    -------------------------------
                              Title:   ***
                                    -------------------------------
                              Address: ***
                                      -----------------------------
                                      ***
                                      -----------------------------
                                      ***
                                      -----------------------------

                     ADDITIONAL INVESTOR SIGNATURE PAGE TO
            SERIES D CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT



***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                             SCHEDULE OF INVESTORS


                                Number of Shares
                                   of Series D                     Aggregate
Initial Investor                 Preferred Stock                 Purchase Price
- ----------------                 ---------------                 --------------
TVM Medical Ventures                 538,461                     $ 3,499,996.50
c/o TVM

TVM Techno Venture Enterprises        36,738*                    $   238,797.00*
No. II Limited Partnership
c/o TVM Techno Venture
Management ("TVM")
101 Arch Street, Suite 1950
Boston, MA 02210

TVM Intertech Limited Partnership     24,492*                    $   159,198.00*
c/o TVM

TVM Zweite Beteiligung-US            122,462*                    $   796,003.00*
Limited Partnership
c/o TVM

TVM Eurotech Limited Partnership           *                                  *
c/o TVM

TVM Techno Venture Investors No. 1     4,615*                    $    29,997.50*
Limited Partnership
c/o TVM

***                                  136,616                     $   888,004.00

***                                  136,615*                    $   887,997.50*

Alpinvest International B.V.         461,538                     $ 2,999,997.00
Gooimeer 3
NL- 1410 AB Naarden
The Netherlands

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                Number of Shares
                                   of Series D                     Aggregate
Initial Investor                 Preferred Stock                 Purchase Price
- ----------------                 ---------------                 --------------

***                                   84,000                     $   546,000.00

Prof. Ernst-Gunter Afting             15,018                     $    97,617.00
Mediconsult
Meisenweg 21
D- 82152 Krailling, Germany

***                                  172,000                     $ 1,118,000.00

***                                  652,686                     $ 4,242,459.00

***                                  461,538                     $ 2,999,997.00

***                                   38,461                     $   249,996.50

***                                  461,538                     $ 2,999,997.00

***                                   15,384                     $    99,996.00

***                                   20,000                     $   130,000.00

***                                  461,538                     $ 2,999,997.00

TOTAL                              3,843,700                     $24,984,050.00
                                   =========                     ==============


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                    TO THE
                        SERIES D CONVERTIBLE PREFERRED
                           STOCK PURCHASE AGREEMENT
                         DATED AS OF DECEMBER 21, 1998

                         Number of Shares of             Aggregate
Investor               Series D Preferred Stock       Purchase Price
- --------               ------------------------       --------------

***                              307,692               $1,999,998.00









     ***.
- --------------------------
Print Name of Investor


By: ***
   -----------------------
Its: ***
   -----------------------
Date: Jan 13/ 99
   -----------------------

Accepted and agreed to this
28th day of February, 1999
- ----        ---------


SEQUENOM, INC.


By: /s/ illegible
   ------------------------
Its: CFO
   -----------------------


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                    TO THE
                        SERIES D CONVERTIBLE PREFERRED
                           STOCK PURCHASE AGREEMENT
                         DATED AS OF DECEMBER 21, 1998

                       Number of Shares of             Aggregate
Investor             Series D Preferred Stock        Purchase Price
- --------             ------------------------        --------------

***                            38,461                  $249,996.50




     ***
- -----------------------------------
Print Name of Investor
***


By: ***
   --------------------------------
Its: ***
   --------------------------------
Date: 1/19/99
   --------------------------------

Accepted and agreed to this
28th day of February, 1999
- ----        ---------


SEQUENOM, INC.


By: /s/ illegible
   ---------------------------------
Its: CFO
   --------------------------------

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                    TO THE
                        SERIES D CONVERTIBLE PREFERRED
                           STOCK PURCHASE AGREEMENT
                         DATED AS OF DECEMBER 21, 1998


                       Number of Shares of             Aggregate
Investor             Series D Preferred Stock        Purchase Price
- --------             ------------------------        --------------

***                            7,692                   $49,998.00








    ***
- ----------------------------
Print Name of Investor


By:            ***
   -------------------------
Its:
   -------------------------
Date: 2/22/99
   -------------------------

Accepted and agreed to this
28th day of February, 1999
- ----        ---------


SEQUENOM, INC.


By: /s/ illegible
   --------------------------
Its: CFO
   -------------------------


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                    TO THE
                        SERIES D CONVERTIBLE PREFERRED
                           STOCK PURCHASE AGREEMENT
                         DATED AS OF DECEMBER 21, 1998



                       Number of Shares of             Aggregate
Investor             Series D Preferred Stock        Purchase Price
- --------             ------------------------        --------------

***                          7,692                     $49,998.00




         ***
- -----------------------------
Print Name of Investor


By:      ***
   --------------------------
Its: ***
   --------------------------
Date: 2/19/99
   --------------------------


Accepted and agreed to this
28th day of February, 1999
- ----        ---------


SEQUENOM, INC.


By: /s/ illegible
   --------------------------
Its: CFO
   --------------------------


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                    TO THE
                        SERIES D CONVERTIBLE PREFERRED
                           STOCK PURCHASE AGREEMENT
                         DATED AS OF DECEMBER 21, 1998


                       Number of Shares of             Aggregate
Investor             Series D Preferred Stock        Purchase Price
- --------             ------------------------        --------------


***                           230,766                 $1,499,979.00




    ***
- -----------------------------
Print Name of Investor


By: ***
   --------------------------
Its:
   --------------------------
Date:
   --------------------------

Accepted and agreed to this
28th day of February, 1999
- ----        ---------


SEQUENOM, INC.


By: /s/ illegible
   --------------------------
Its: CFO
   --------------------------


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                    TO THE
                        SERIES D CONVERTIBLE PREFERRED
                           STOCK PURCHASE AGREEMENT
                         DATED AS OF DECEMBER 21, 1998


                       Number of Shares of             Aggregate
Investor             Series D Preferred Stock        Purchase Price
- --------             ------------------------        --------------

***                          308,000                  $2,002,000




      ***
- ------------------------------
Print Name of Investor
***


By:   ***
   ---------------------------
Its: ***
   ---------------------------
Date: 22 February 1999
   ---------------------------


Accepted and agreed to this
28th day of February, 1999
- ----        ---------


SEQUENOM, INC.


By: /s/ illegible
   ---------------------------
Its: CFO
   ---------------------------



***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                    TO THE
                        SERIES D CONVERTIBLE PREFERRED
                           STOCK PURCHASE AGREEMENT
                         DATED AS OF DECEMBER 21, 1998


                       Number of Shares of             Aggregate
Investor             Series D Preferred Stock        Purchase Price
- --------             ------------------------        --------------

***                         52,300                      $339,950




       ***
- -------------------------------------------
Print Name of Investor


By: ***                 ***
   -------------------  --------------------
Its: ***                ***
   -------------------  --------------------
Date: 28 February  1999
   -----------------------------------------


Accepted and agreed to this
28th day of March, 1999
- ----        ------


SEQUENOM, INC.


By: /s/ illegible
   -------------------------------------------
Its: CFO
   -------------------------------------------



***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                    TO THE
                        SERIES D CONVERTIBLE PREFERRED
                           STOCK PURCHASE AGREEMENT
                         DATED AS OF DECEMBER 21, 1998

                       Number of Shares of             Aggregate
Investor             Series D Preferred Stock        Purchase Price
- --------             ------------------------        --------------

                               38,000                    $247,000




       ***
- ---------------------------
Print Name of Investor


By:     ***
    -----------------------
Its:
    -----------------------
Date:
    -----------------------

Accepted and agreed to this
30th day of March, 1999
- ----        ------


SEQUENOM, INC.


By:  /s/ illegible
   -------------------------
Its: CFO
    -----------------------



***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                    TO THE
                        SERIES D CONVERTIBLE PREFERRED
                           STOCK PURCHASE AGREEMENT
                         DATED AS OF DECEMBER 21, 1998


                       Number of Shares of             Aggregate
Investor             Series D Preferred Stock        Purchase Price
- --------             ------------------------        --------------

***                         109,230                    709,995 USD




      ***
- -----------------------------
Print Name of Investor


By:   ***
   --------------------------
Its:
   --------------------------
Date: 28/2/99
   --------------------------


Accepted and agreed to this
30th day of March, 1999
- ----        ------


SEQUENOM, INC.


By: /s/ illegible
   ---------------------------
Its: CFO
   --------------------------



***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                ADDENDUM TO THE
                             SCHEDULE OF INVESTORS
                                    TO THE
                        SERIES D CONVERTIBLE PREFERRED
                           STOCK PURCHASE AGREEMENT
                         DATED AS OF DECEMBER 21, 1998

                       Number of Shares of             Aggregate
Investor             Series D Preferred Stock        Purchase Price
- --------             ------------------------        --------------

***                          769,230                  $4,999,995.00




       ***
- -------------------------------
Print Name of Investor


By: ***
   ----------------------------
Its: ***
   ----------------------------
Date: 29 March 1999
   ----------------------------


Accepted and agreed to this
___ day of ______________, 1999


SEQUENOM, INC.


By:
   ----------------------------
Its:
   ----------------------------



***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                  EXHIBIT 4.1

                         Foreign Qualification; Bylaws
                         -----------------------------

    The Corporation is qualified to do business in Massachusetts and

California.

     A copy of the Bylaws are attached hereto.
<PAGE>

                                    BYLAWS

                                      OF

                                SEQUENOM, INC.
<PAGE>

                                    BYLAWS
                                      OF
                                SEQUENOM, INC.

     Section 1.    CERTIFICATE OF INCORPORATION AND BYLAWS
     ---------     ---------------------------------------

     1.1  These Bylaws are subject to the certificate of incorporation of the
corporation.  In these bylaws, references to the certificate of incorporation
and bylaws mean the provisions of the certificate of incorporation and the
bylaws as are from time to time in effect.

     Section 2.    OFFICES
     ---------     -------

     2.1  Registered Office.  The registered office shall be in the City of
          -----------------
Wilmington, County of New Castle, State of Delaware.

     2.2  Other Offices.  The corporation may also have offices at such other
          -------------
places both within and without the State of Delaware as the board of directors
may from time to time determine or the business of the corporation may require.

     Section 3.    STOCKHOLDERS
     ---------     ------------

     3.1  Location of Meetings.  All meetings of the stockholders shall be held
          --------------------
at such place either within or without the State of Delaware as shall be
designated from time to time by the board of directors.  Any adjourned session
of any meeting shall be held at the place designated in the vote of adjournment.

     3.2  Annual Meeting.  The annual meeting of stockholders shall be held at
          --------------
10:00 a.m. on the second Wednesday in May in each year, unless that day be a
legal holiday at the place where the meeting is to be held, in which case the
meeting shall be held at the same hour on the next succeeding day not a legal
holiday, or at such other date and time as shall be designated from time to time
by the board of directors, at which they shall elect a board of directors and
transact such other business as may be required by law or these bylaws or as may
properly come before the meeting.

     3.3  Special Meeting in Place of Annual Meeting.  If the election for
          ------------------------------------------
directors shall not be held on the day designated by these bylaws, the directors
shall cause the election to be held as soon thereafter as convenient, and to
that end, if the annual meeting is omitted on the day herein provided therefor
or if the election of directors shall not be held thereat, a special meeting of
the stockholders may be held in place of such omitted meeting or election, and
any business transacted or election held at such special meeting shall have the
same effect as if transacted or held at the annual meeting, and in such case all
references in these bylaws to the annual meeting of the stockholders, or to the
annual election of directors, shall be deemed to refer to or include such
special meeting.  Any such special meeting shall be called and the purposes
thereof shall be specified in the call, as provided in Section 3.4.

     3.4  Notice of Annual Meeting.  Written notice of the annual meeting
          ------------------------
stating the place, date and hour of the meeting shall be given to each
stockholder entitled to vote at such meeting not less than ten nor more than
sixty days before the date of the meeting.  Such notice may
<PAGE>

specify the business to be transacted and actions to be taken at such meeting.
No action shall be taken at such meeting unless such notice is given, or unless
waiver of such notice is given by the holders of outstanding stock having not
less than the minimum number of votes necessary to take such action at a meeting
at which all shares entitled to vote thereon were voted. Prompt notice of all
action taken in connection with such waiver of notice shall be given to all
stockholders not present or represented at such meeting.

     3.5  Other Special Meetings.  Special meetings of the stockholders, for any
          ----------------------
purpose or purposes, unless otherwise prescribed by law or by the certificate of
incorporation, may be called by the president and shall be called by the
president or secretary at the request in writing of a majority of the board of
directors, or at the request in writing of the holders of at least ten percent
of all capital stock of the corporation issued and outstanding and entitled to
vote at such meeting.  Such request shall state the purpose or purposes of the
proposed meeting and business to be transacted at any special meeting of the
stockholders.

     3.6  Notice of Special Meeting.  Written notice of a special meeting
          -------------------------
stating the place, date and hour of the meeting and the purpose or purposes for
which the meeting is called, shall be given not less than ten nor more than
sixty days before the date of the meeting, to each stockholder entitled to vote
at such meeting.  No action shall be taken at such meeting unless such notice is
given, or unless waiver of such notice is given by the holders of outstanding
stock having not less than the minimum number of votes necessary to take such
action at a meeting at which all shares entitled to vote thereon were voted.
Prompt notice of all action taken in connection with such waiver of notice shall
be given to all stockholders not present or represented at such meeting.

     3.7  Stockholder List.  The officer who has charge of the stock ledger of
          ----------------
the corporation shall prepare and make, at least ten days before every meeting
of stockholders, a complete list of the stockholders entitled to vote at the
meeting, arranged in alphabetical order, and showing the address of each
stockholder and the number of shares registered in the name of each stockholder.
Such list shall be open to the examination of any stockholder, for any purpose
germane to the meeting, during ordinary business hours, for a period of at least
ten days prior to the meeting, either at a place within the city where the
meeting is to be held, which place shall be specified in the notice of the
meeting, or, if not so specified, at the place where the meeting is to be held.
The list shall also be produced and kept at the time and place of the meeting
during the whole time thereof, and may be inspected by any stockholder who is
present.

     3.8  Quorum of Stockholders.  The holders of a majority of the stock issued
          ----------------------
and outstanding and entitled to vote thereat, present in person or represented
by proxy, shall constitute a quorum at all meetings of the stockholders for the
transaction of business except as otherwise required by law, or by the
certificate of incorporation or by these bylaws.  Except as otherwise provided
by law, no stockholder present at a meeting may withhold his shares from the
quorum count by declaring his shares absent from the meeting.

     3.9  Adjournment.  Any meeting of stockholders may be adjourned from time
          -----------
to time to any other time and to any other place at which a meeting of
stockholders may be held under these bylaws, which time and place shall be
announced at the meeting, by a majority of votes cast upon the question, whether
or not a quorum is present.  At such adjourned meeting at which a quorum shall
be present or represented any business may be transacted which might have been

                                       2
<PAGE>

transacted at the original meeting.  If the adjournment is for more than thirty
days, or if after the adjournment a new record date is fixed for the adjourned
meeting, a notice of the adjourned meeting shall be given to each stockholder of
record entitled to vote at the meeting.

     3.10  Proxy Representation.  Every stockholder may authorize another person
           --------------------
or persons to act for him by proxy in all matters in which a stockholder is
entitled to participate, whether by waiving notice of any meeting, objecting to
or voting or participating at a meeting, or expressing consent or dissent
without a meeting.  Every proxy must be signed by the stockholder or by his
attorney-in-fact.  No proxy shall be voted or acted upon after three years from
its date unless such proxy provides for a longer period.  Except as provided by
law, a revocable proxy shall be deemed revoked if the stockholder is present at
the meeting for which the proxy was given.  A duly executed proxy shall be
irrevocable if it states that it is irrevocable and, if, and only as long as, it
is coupled with an interest sufficient in law to support an irrevocable power.
A proxy may be made irrevocable regardless of whether the interest with which it
is coupled is an interest in the stock itself or an interest in the corporation
generally.  The authorization of a proxy may but need not be limited to
specified action, provided, however, that if a proxy limits its authorization to
a meeting or meetings of stockholders, unless otherwise specifically provided
such proxy  shall entitle the holder thereof to vote at any adjourned session
but shall not be valid after the final adjournment thereof.

     3.11  Inspectors.  The directors or the person presiding at the meeting
           ----------
may, but need not, appoint one or more inspectors of election and any substitute
inspectors to act at the meeting or any adjournment thereof.  Each inspector,
before entering upon the discharge of his duties, shall take and sign an oath
faithfully to execute the duties of inspector at such meeting with strict
impartiality and according to the best of his ability.  The inspectors, if any,
shall determine the number of shares of stock outstanding and the voting power
of each, the shares of stock represented at the meeting, the existence of a
quorum and the validity and effect of proxies, and shall receive votes, ballots
or consents, hear and determine all challenges and questions arising in
connection with the right to vote, count and tabulate all votes, ballots or
consents, determine the result, and do such acts as are proper to conduct the
election or vote with fairness to all stockholders.  On request of the person
presiding at the meeting, the inspectors shall make a report in writing of any
challenge, question or matter determined by them and execute a certificate of
any fact found by them.

     3.12  Action by Vote.  When a quorum is present at any meeting, whether the
           --------------
same be an original or an adjourned session, a plurality of the votes properly
cast for election to any office shall elect to such office and a majority of the
votes properly cast upon any question other than an election to an office shall
decide the question, except when a larger vote is required by law, by the
certificate of incorporation or by these bylaws.  No ballot shall be required
for any election unless requested by a stockholder present or represented at the
meeting and entitled to vote in the election.

     3.13  Action Without Meetings.  Unless otherwise provided in the
           -----------------------
certificate of incorporation, any action required to be taken at any annual or
special meeting of stockholders of the corporation, or any action which may be
taken at any annual or special meeting of such stockholders, may be taken
without a meeting, without prior notice and without a vote, if a consent in
writing, setting forth the action so taken shall be signed by the holders of
outstanding stock having not less than the minimum number of votes that would be
necessary to authorize

                                       3
<PAGE>

or take such action at a meeting at which all shares entitled to vote thereon
were present and voted. Prompt notice of the taking of the corporate action
without a meeting by less than unanimous written consent shall be given to those
stockholders who have not consented in writing.

     Section 4.    DIRECTORS
     ---------     ---------

     4.1  Number.  The number of directors which shall constitute the whole
          ------
board shall not be less than three nor more than seven,  except that whenever
there shall be only one stockholder or prior to issuance of any stock, the
number of directors which shall constitute the whole board shall be not less
than one.  Within the foregoing limits, the stockholders at the annual meeting
shall determine the number of directors, and within such limits, the number of
directors may be increased or decreased at any time or from time to time by the
stockholders or by the directors by vote of a majority of directors then in
office, except that any such decrease by vote of the directors shall only be
made to eliminate vacancies existing by reason of the death, resignation or
removal of one or more directors.  The directors shall be elected at the annual
meeting of the stockholders, except as provided in Section 4.4 of these bylaws.
Directors need not be stockholders.

     4.2  Tenure.  Except as otherwise provided by law, by the certificate of
          ------
incorporation or by these bylaws, each director shall hold office until the next
annual meeting and until his successor is elected and qualified, or until he
sooner dies, resigns, is removed or becomes disqualified.

     4.3  Powers.  The business of the corporation shall be managed by or under
          ------
the direction of the board of directors which shall have and may exercise all
the powers of the corporation and do all such lawful acts and things as are not
by law, the certificate of incorporation or these bylaws directed or required to
be exercised or done by the stockholders.

     4.4  Vacancies.  Vacancies and any newly created directorships resulting
          ---------
from any increase in the number of directors may be filled by vote of the
stockholders at a meeting called for the purpose, or by a majority of the
directors then in office, although less than a quorum, or by a sole remaining
director. When one or more directors shall resign from the board, effective at a
future date, a majority of the directors then in office, including those who
have resigned, shall have power to fill such vacancy or vacancies, the vote or
action by writing thereon to take effect when such resignation or resignations
shall become effective.  The directors shall have and may exercise all their
powers notwithstanding the existence of one or more vacancies in their number,
subject to any requirements of law or of the certificate of incorporation or of
these bylaws as to the number of directors required for a quorum or for any vote
or other actions.

     4.5  Committees.  The board of directors may, by vote of a majority of the
          ----------
whole board, (a) designate, change the membership of or terminate the existence
of any committee or committees, each committee to consist of one or more of the
directors; (b) designate one or more directors as alternate members of any such
committee who may replace any absent or disqualified member at any meeting of
the committee; and (c) determine the extent to which each such committee shall
have and may exercise the powers  and authority of the board of directors in the
management of the business and affairs of the corporation, including the power
to authorize the seal of the corporation to be affixed to all papers which
require it and the power and authority to declare dividends or to authorize the
issuance of stock; excepting, however, such

                                       4
<PAGE>

powers which by law, by the certificate of incorporation or by these bylaws they
are prohibited from so delegating. In the absence or disqualification of any
member of such committee and his alternate, if any, the member or members
thereof present at any meeting and not disqualified from voting, whether or not
constituting a quorum, may unanimously appoint another member of the board of
directors to act at the meeting in the place of any such absent or disqualified
member. Except as the board of directors may otherwise determine, any committee
may make rules for the conduct of its business, but unless otherwise provided by
the board or such rules, its business shall be conducted as nearly as may be in
the same manner as is provided by these bylaws for the conduct of business by
the board of directors. Each committee shall keep regular minutes of its
meetings and report the same to the board of directors upon request.

     4.6  Regular Meeting.  Regular meetings of the board of directors may be
          ---------------
held without call or notice at such place within or without the State of
Delaware and at such times as the board may from time to time determine,
provided that notice of the first regular meeting following any such
determination shall be given to absent directors.  A regular meeting of the
directors may be held without call or notice immediately after and at the same
place as the annual meeting of the stockholders.

     4.7  Special Meetings.  Special meetings of the board of directors may be
          ----------------
held at any time and at any place within or without the State of Delaware
designated in the notice of the meeting, when called by the president, or by
one-third or more in number of the directors, reasonable notice thereof being
given to each director by the secretary or by the president or by any one of the
directors calling the meeting.

     4.8  Notice.  It shall be reasonable and sufficient notice to a director to
          ------
send notice by mail at least forty-eight hours or by telegram at least twenty-
four hours before the meeting, addressed to him at his usual or last known
business or residence address or to give notice to him in person or by telephone
at least twenty-four hours before the meeting.  Notice of a meeting need not be
given to any director if a written waiver of notice, executed by him before or
after the meeting, is filed with the records of the meeting, or to any director
who attends the meeting without protesting prior thereto or at its commencement
the lack of notice to him.  Neither notice of a meeting nor a waiver of a notice
need specify the purposes of the meeting.

     4.9  Quorum.  Except as may be otherwise provided by law, by the
          ------
certificate of incorporation or by these bylaws, at any  meeting of the
directors a majority of the directors then in office shall constitute a quorum;
a quorum shall not in any case be less than one-third of the total number of
directors constituting the whole board.  Any meeting may be adjourned from time
to time by a majority of the votes cast upon the question, whether or not a
quorum is present, and the meeting may be held as adjourned without further
notice.

     4.10  Action by Vote.  Except as may be otherwise provided by law, by the
           --------------
certificate of incorporation or by these bylaws, when a quorum is present at any
meeting the vote of a majority of the directors present shall be the act of the
board of directors.

     4.11  Action Without a Meeting.  Unless otherwise restricted by the
           ------------------------
certificate of incorporation or these bylaws, any action required or permitted
to be taken at any meeting of the board of directors or of any committee thereof
may be taken without a meeting if all the members of the board or of such
committee, as the case may be, consent thereto in writing, and

                                       5
<PAGE>

such writing or writings are filed with the records of the meetings of the board
or of such committee. Such consent shall be treated for all purposes as the act
of the board or of such committee, as the case may be.

     4.12  Participation in Meetings by Conference Telephone. Unless otherwise
           -------------------------------------------------
restricted by the certificate of incorporation or these bylaws, members of the
board of directors or of any committee thereof may participate in a meeting of
such board or committee by means of conference telephone or similar
communications equipment by means of which all persons participating in the
meeting can hear each other.  Such participation shall constitute presence in
person at such meeting.

     4.13  Compensation.  Unless otherwise restricted by the certificate of
           ------------
incorporation or these bylaws, the board of directors shall have the authority
to fix from time to time the compensation of directors.  The directors may be
paid their expenses, if any, of attendance at each meeting of the board of
directors and the performance of their responsibilities as directors and may be
paid a fixed sum for attendance at each meeting of the board of directors and/or
a stated salary as director.  No such payment shall preclude any director from
serving the corporation or its parent or subsidiary corporations in any other
capacity and receiving compensation therefor.  The board of directors may also
allow compensation for members of special or standing committees for service on
such committees.

     4.14  Interested Directors and Officers.
           ---------------------------------

     (a)   No contract or transaction between the corporation and one or more of
its directors or officers, or between the corporation and any other corporation,
partnership, association,  or other organization in which one or more of the
corporation's directors or officers are directors or officers, or have a
financial interest, shall be void or voidable solely for this reason, or solely
because the director or officer is present at or participates in the meeting of
the board or committee thereof which authorizes the contract or transaction, or
solely because his or their votes are counted for such purpose, if:

           (1) The material facts as to his relationship or interest and as to
the contract or transaction are disclosed or are known to the board of directors
or the committee, and the board or committee in good faith authorizes the
contract or transaction by the affirmative votes of a majority of the
disinterested directors, even though the disinterested directors be less than a
quorum; or

           (2) The material facts as to his relationship or interest and as to
the contract or transaction are disclosed or are known to the stockholders
entitled to vote thereon, and the contract or transaction is specifically
approved in good faith by vote of the stockholders; or

           (3) The contract or transaction is fair as to the corporation as of
the time it is authorized, approved or ratified, by the board of directors, a
committee thereof, or the stockholders.

     (b)   Common or interested directors may be counted in determining the
presence of a quorum at a meeting of the board of directors or of a committee
which authorizes the contract or transaction.

                                       6
<PAGE>

     4.15  Resignation or Removal of Directors.  Unless otherwise restricted by
           -----------------------------------
the certificate of incorporation or by law, any director or the entire board of
directors may be removed, with or without cause, by the holders of a majority of
the stock issued and outstanding and entitled to vote at an election of
directors. Any director may resign at any time by delivering his resignation in
writing to the president or the secretary or to a meeting of the board of
directors.  Such resignation shall be effective upon receipt unless specified to
be effective at some other time; and without in either case the necessity of its
being accepted unless the resignation shall so state.  No director resigning and
(except where a right to receive compensation shall be expressly provided in a
duly authorized written agreement with the corporation) no director removed
shall have any right to receive compensation as such director for any period
following his resignation or removal, or any right to damages on account of such
removal, whether his compensation be by the month or by the year or otherwise;
unless in the case of a resignation, the directors, or in the case of removal,
the body acting on the removal, shall in their or its discretion provide for
compensation.

     Section 5.    NOTICES
     ---------     -------

     5.1  Form of Notice.  Whenever, under the provisions of law, or of the
          --------------
certificate of incorporation or of these bylaws, notice is required to be given
to any director or stockholder, such notice may be given by mail, addressed to
such director or stockholder, at his address as it appears on the records of the
corporation, with postage thereon prepaid, and such notice shall be deemed to be
given at the time when the same shall be deposited in the United States mail.
Unless written notice by mail is required by law, written notice may also be
given by telegram, cable, telecopy, commercial delivery service, telex or
similar means, addressed to such director or stockholder at his address as it
appears on the records of the corporation, in which case such notice shall be
deemed to be given when delivered into the control of the persons charged with
effecting such transmission, the transmission charge to be paid by the
corporation or the person sending such notice and not by the addressee.  Oral
notice or other in-hand delivery (in person or by telephone) shall be deemed
given at the time it is actually given.

     5.2  Waiver of Notice.  Whenever notice is required to be given under the
          ----------------
provisions of law, the certificate of incorporation or these bylaws, a written
waiver thereof, signed by the person entitled to notice, whether before or after
the time stated therein, shall be deemed equivalent to notice.  Attendance of a
person at a meeting shall constitute a waiver of notice of such meeting, except
when the person attends a meeting for the express purpose of objecting, at the
beginning of the meeting, to the transaction of any business because the meeting
is not lawfully called or convened.  Neither the business to be transacted at,
nor the purpose of, any meeting of the stockholders, directors or members of a
committee of the directors need be specified in any written waiver of notice.

     Section 6.    OFFICERS AND AGENTS
     ---------     -------------------

     6.1  Enumeration; Qualification.  The officers of the corporation shall be
          --------------------------
a president, a treasurer, a secretary and such other officers, if any, as the
board of directors from time to time may in its discretion elect or appoint
including without limitation one or more vice presidents.  Any officer may be,
but none need be, a director or stockholder.  Any two or more offices may be
held by the same person.  Any officer may be required by the board of directors
to secure the

                                       7
<PAGE>

faithful performance of his duties to the corporation by giving bond in such
amount and with sureties or otherwise as the board of directors may determine.

     6.2  Powers.  Subject to law, to the certificate of incorporation and to
          ------
the other provisions of these bylaws, each officer shall have, in addition to
the duties and powers herein set forth, such duties and powers as are commonly
incident to his  office and such additional duties and powers as the board of
directors may from time to time designate.

     6.3  Election.  The board of directors at its first meeting after each
          --------
annual meeting of stockholders shall choose a president, a secretary and a
treasurer.  Other officers may be appointed by the board of directors at such
meeting, at any other meeting or by written consent.  At any time or from time
to time, the directors may delegate to any officer their power to elect or
appoint any other officer or any agents.

     6.4  Tenure.  Each officer shall hold office until the first meeting of the
          ------
board of directors following the next annual meeting of the stockholders and
until his successor is elected and qualified unless a shorter period shall have
been specified in terms of his election or appointment, or in each case until he
sooner dies, resigns, is removed or becomes disqualified.  Each agent of the
corporation shall retain his authority at the pleasure of the directors, or the
officer by whom he was appointed or by the officer who then holds agent
appointive power.

     6.5  President and Vice Presidents.  The president shall be the chief
          -----------------------------
executive officer and shall have direct and active charge of all business
operations of the corporation and shall have general supervision of the entire
business of the corporation, subject to the control of the board of directors.
He shall preside at all meetings of the stockholders and of the board of
directors at which he is present, except as otherwise voted by the board of
directors.

     The president or treasurer shall execute bonds, mortgages and other
contracts requiring a seal, under the seal of the corporation, except where
required or permitted by law to be otherwise signed and executed and except
where the signing and execution thereof shall be expressly delegated by the
board of directors to some other officer or agent of the corporation.

     Any vice presidents shall have such duties and powers as shall be
designated from time to time by the board of directors or by the president.

     6.6  Treasurer and Assistant Treasurers.  The treasurer shall be the chief
          ----------------------------------
financial officer of the corporation and shall be in charge of its funds and
valuable papers, and shall have such other duties and powers as may be assigned
to him from time to time by the board of directors or by the president.

     Any assistant treasurers shall have such duties and powers as shall be
designated from time to time by the board of directors, the president or the
treasurer.

     6.7  Secretary and Assistant Secretaries.  The secretary shall record all
          -----------------------------------
proceedings of the stockholders, of the board of  directors and of committees of
the board of directors in a book or series of books to be kept therefor and
shall file therein all writings of, or related to, action by stockholder or
director consent.  In the absence of the secretary from any meeting, an
assistant secretary, or if there is none or he is absent, a temporary secretary
chosen at the meeting, shall

                                       8
<PAGE>

record the proceedings thereof. Unless a transfer agent has been appointed, the
secretary shall keep or cause to be kept the stock and transfer records of the
corporation, which shall contain the names and record addresses of all
stockholders and the number of shares registered in the name of each
stockholder. The secretary shall have such other duties and powers as may from
time to time be designated by the board of directors or the president.

     Any assistant secretaries shall have such duties and powers as shall be
designated from time to time by the board of directors, the president or the
secretary.

     6.8  Resignation and Removal.  Any officer may resign at any time by
          -----------------------
delivering his resignation in writing to the president or the secretary or to a
meeting of the board of directors.  Such resignation shall be effective upon
receipt unless specified to be effective at some other time, and without in any
case the necessity of its being accepted unless the resignation shall so state.
The board of directors may at any time remove any officer either with or without
cause.  The board of directors may at any time terminate or modify the authority
of any agent.  No officer resigning and (except where a right to receive
compensation shall be expressly provided in a duly authorized written agreement
with the corporation) no officer removed shall have any right to any
compensation as such officer for any period following his resignation or
removal, or any right to damages on account of such removal, whether his
compensation be by the month or by the year or otherwise; unless in the case of
a resignation, the directors, or in the case of removal, the body acting on the
removal, shall in their or its discretion provide for compensation.

     6.9  Vacancies.  If the office of the president or the treasurer or the
          ---------
secretary becomes vacant, the directors may elect a successor by vote of a
majority of the directors then in office.  If the office of any other officer
becomes vacant, any person or body empowered to elect or appoint that office may
choose a successor.  Each such successor shall hold office for the unexpired
term of his predecessor, and in the case of the president, the treasurer and the
secretary until his successor is chosen and qualified, or in each case until he
sooner dies, resigns, is removed or becomes disqualified.

     Section 7.    CAPITAL STOCK
     ---------     -------------

     7.1  Stock Certificates.  Each stockholder shall be entitled to a
          ------------------
certificate stating the number and the class and the  designation of the series,
if any, of the shares held by him, in such form as shall, in conformity to law,
the certificate of incorporation and the bylaws, be prescribed from time to time
by the board of directors.  Such certificate shall be signed by the president or
a vice-president and (i) the treasurer or an assistant treasurer or (ii) the
secretary or an assistant secretary.  Any of or all the signatures on the
certificate may be a facsimile.  In case an officer, transfer agent or registrar
who has signed or whose facsimile signature has been placed on such certificate
shall have ceased to be such officer, transfer agent or registrar before such
certificate is issued, it may be issued by the corporation with the same effect
as if he were such officer, transfer agent, or registrar at the time of its
issue.

     7.2  Lost Certificates.  The board of directors may direct a new
          -----------------
certificate or certificates to be issued in place of any certificate or
certificates theretofore issued by the corporation alleged to have been lost,
stolen or destroyed, upon the making of an affidavit of that fact by the person
claiming the certificate of stock to be lost, stolen or destroyed.  When
authorizing such issue of a new certificate or certificates, the board of
directors may, in its

                                       9
<PAGE>

discretion and as a condition precedent to the issuance thereof, require the
owner of such lost, stolen or destroyed certificate or certificates, or his
legal representative, to advertise the same in such manner as it shall require
and/or to give the corporation a bond in such sum as it may direct as indemnity
against any claim that may be made against the corporation with respect to the
certificate alleged to have been lost, stolen or destroyed.

     Section 8.    TRANSFER OF SHARES OF STOCK
     ---------     ---------------------------

     8.1  Transfer on Books.  Subject to any restrictions with respect to the
          -----------------
transfer of shares of stock, shares of stock may be transferred on the books of
the corporation by the surrender to the corporation or its transfer agent of the
certificate therefor properly endorsed or accompanied by a written assignment
and power of attorney properly executed, with necessary transfer stamps affixed,
and with such proof of the authenticity of signature as the board of directors
or the transfer agent of the corporation may reasonably require.  Except as may
be otherwise required by law, by the certificate of incorporation or by these
bylaws, the corporation shall be entitled to treat the record holder of stock as
shown on its books as the owner of such stock for all purposes, including the
payment of dividends and the right to receive notice and to vote or to give any
consent with respect thereto and to be held liable for such calls and
assessments, if any, as may lawfully be made thereon, regardless of any
transfer, pledge or other disposition of such stock until the shares have been
properly transferred on the books of the corporation.

     It shall be the duty of each stockholder to notify the corporation of his
post office address.

     Section 9.    GENERAL PROVISIONS
     ---------     ------------------

     9.1  Record Date.  In order that the corporation may determine the
          -----------
stockholders entitled to notice of or to vote at any meeting of stockholders or
any adjournment thereof, or to express consent to corporate action in writing
without a meeting, or entitled to receive payment of any dividend or other
distribution or allotment of any rights, or entitled to exercise any rights in
respect of any change, conversion or exchange of stock or for the purpose of any
other lawful action, the board of directors may fix, in advance, a record date,
which shall not be more than sixty days nor less than ten days before the date
of such meeting, nor more than sixty days prior to any other action to which
such record date relates.  A determination of stockholders of record entitled to
notice of or to vote at a meeting of stockholders shall apply to any adjournment
of the meeting; provided, however, that the board of directors may fix a new
record date for the adjourned meeting.  If no record date is fixed,

     (a)   The record date for determining stockholders entitled to notice of or
to vote at a meeting of stockholders shall be at the close of business on the
day next preceding the day on which notice is given, or, if notice is waived, at
the close of business on the day next preceding the day on which the meeting is
held;

     (b)   The record date for determining stockholders entitled to express
consent to corporate action in writing without a meeting, when no prior action
by the board of directors is necessary, shall be the day on which the first
written consent is expressed; and

                                      10
<PAGE>

     (c)   The record date for determining stockholders for any other purpose
shall be at the close of business on the day on which the board of directors
adopts the resolution relating to such purpose.

     9.2  Dividends.  Dividends upon the capital stock of the corporation may be
          ---------
declared by the board of directors at any regular or special meeting or by
written consent, pursuant to law.  Dividends may be paid in cash, in property,
or in shares of the capital stock, subject to the provisions of the certificate
of incorporation.

     9.3  Payment of Dividends.  Before payment of any dividend, there may be
          --------------------
set aside out of any funds of the corporation available for dividends such sum
or sums as the directors from time to time, in their absolute discretion, think
proper as a reserve or reserves to meet contingencies, or for equalizing
dividends, or  for repairing or maintaining any property of the corporation, or
for such other purpose as the directors shall think conducive to the interest of
the corporation, and the directors may modify or abolish any such reserve in the
manner in which it was created.

     9.4  Checks.  All checks or demands for money and notes of the corporation
          ------
shall be signed by such officer or officers or such other person or persons as
the board of directors may from time to time designate.

     9.5  Fiscal Year.  The fiscal year of the corporation shall begin on the
          -----------
first of January in each year and shall end on the last day of December next
following, unless otherwise determined by the board of directors.

     9.6  Seal.  The board of directors may, by resolution, adopt a corporate
          ----
seal.  The corporate seal shall have inscribed thereon the name of the
corporation, the year of its organization and the word "Delaware."  The seal may
be used by causing it or a facsimile thereof to be impressed or affixed or
reproduced or otherwise.  The seal may be altered from time to time by the board
of directors.

     Section 10.    INDEMNIFICATION
     ----------     ---------------

     10.1  It being the intent of the corporation to provide maximum protection
available under the law to its officers and directors, the corporation shall
indemnify its officers and directors to the full extent the corporation is
permitted or required to do so by the General Corporation Law of Delaware.  In
furtherance of and not in limitation of the foregoing, the corporation shall
advance expenses, including attorneys' fees, incurred by an officer or director
of the corporation in defending any civil, criminal, administrative or
investigative action, suit or  proceeding in advance of the final disposition of
such action, suit or proceeding upon receipt of an undertaking by or on behalf
of such director or officer to repay such advances if it shall be ultimately
determined that he is not entitled to be indemnified by the corporation.  The
corporation shall have the power to purchase and maintain insurance on behalf of
any person who is or was a director, officer, employee or agent of the
corporation, or who is or was serving at the request of the corporation as a
director, officer, employee or agent of another corporation, partnership, joint
venture, trust or other enterprise, against any liability asserted against such
person and incurred by such person in any such capacity, or arising out of such
person's status

                                      11
<PAGE>

as such, whether or not the corporation has the power to indemnify such person
under the General Corporation Law of Delaware.

     Section 11.    AMENDMENTS
     ----------     ----------

     11.1  These bylaws may be altered, amended or repealed or new bylaws may be
adopted by the stockholders or by the board of directors when such power is
conferred upon the board of directors by the certificate of incorporation, at
any regular meeting of the stockholders or of the board of directors or at any
special meeting of the stockholders or of the board of directors.  If the power
to adopt, amend or repeal bylaws is conferred upon the board of directors by the
certificate of incorporation, it shall not divest or limit the power of the
stockholders to adopt, amend or repeal bylaws.

                                      12
<PAGE>

                                  EXHIBIT 4.2

                                Capitalization
                                --------------

     Attached hereto is a stockholder list dated December 21, 1998.

     Attached hereto is a list of outstanding stock options and warrants dated
December 21, 1998.

     The Corporation has reserved the number of shares of its capital stock set
forth below:

Common Stock:
- -------------

     Exercise of Options:                                         2,700,000
     Conversion of
        Series A Preferred:                                       1,650,000
        Series B Preferred:                                       2,976,663
        Series C Preferred:                                       4,679,834*
        Series D Preferred:                                       6,153,850
     Exercise of TBG Silent Partnership Exchange Option:            725,624
                                                                 ----------
        Total:                                                   18,885,971
                                                                 ==========

Series A Preferred:
- -------------------

     Exercise of Comdisco Warrant:                                   70,000

Series C Preferred:
- -------------------

     Exercise of Warrants:                                          106,503


*  The total number of reserved Series C Preferred Stock shares listed includes
the conversion of TBG's DM 3 million equity investment into Series C Preferred
Shares of Sequenom, Inc. immediately prior to the Initial Closing.
<PAGE>

                                 SEQUENOM, INC.


                                STOCKHOLDER LIST


                               DECEMBER 21, 1998

<TABLE>
<CAPTION>
AUTHORIZED:
                                                                    PAR VALUE            AUTHORIZED              ISSUED
                                                                    ---------            ----------             ---------
<S>                                                                 <C>                  <C>                    <C>
Common:                                                             $   .001             34,960,347               337,350
Series A Convertible Preferred:                                     $   .001              1,650,000             1,580,000
Series B Convertible Preferred:                                     $   .001              2,976,663             2,976,663
Series C Convertible Preferred:                                     $   .001              4,679,834             4,573,331
Series D Convertible Preferred:                                     $   .001              6,153,850                     0



                                                           COMMON STOCK
                                                           ------------

STOCKHOLDER                                                          SHARES          CERT. NO.                  ISSUE DATE
- -----------                                                          ------          ---------                  ----------
Hubert Koster                                                              1           C-10                      03-08-95
Hallerstrasse 74
20146 Hamburg, Germany
***                                                                   90,000           C-11                      10-16-95
***                                                                   26,250           C-12                      10-31-95
***                                                                   10,000           C-13                      12-01-95
Helmut Schuhsler                                                      10,000           C-14                      12-01-95
c/o TVM Techno Venture Management
Denninger Str. 15
81679 Munich, Germany
Patricia Dane                                                          2,000           C-15                      12-01-95
c/o TVM Techno Venture Management
101 Arch Street
Suite 1950
Boston, MA 02110
</TABLE>

*** Portions of this page have been ommitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

<TABLE>
<CAPTION>
                                                           COMMON STOCK
                                                           ------------

STOCKHOLDER                                                          SHARES          CERT. NO.                  ISSUE DATE
- -----------                                                          ------          ---------                  ----------
<S>                                                                  <C>             <C>                        <C>
Amy B. Crawford                                                        2,000           C-16                      12-01-95
c/o TVM Techno Venture Management
101 Arch Street
Suite 1950
Boston, MA 02110
Monica Schlawinsky                                                     2,000           C-17                      12-01-95
c/o TVM Techno Venture Management
101 Arch Street
Suite 1950
Boston, MA 02110
John J. Di Bello                                                       6,000           C-18                      12-01-95
c/o TVM Techno Venture Management
101 Arch Street
Suite 1950
Boston, MA 02110
***                                                                  144,000           C-19                      06-19-97
***                                                                   13,500           C-20                      05-26-98
***                                                                    5,000           C-21                      06-24-98
***                                                                   17,250           C-22                      10-01-98
***                                                                    6,349
Charles Canter                                                         3,000
526 E. Stanford Court
Del Mar, CA 92014
                  TOTAL:                                             337,350
</TABLE>

*** Portions of this page have been ommitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                      SERIES A CONVERTIBLE PREFERRED STOCK
                      ------------------------------------

<TABLE>
<CAPTION>
SHAREHOLDER                                                        SHARES                 CERT. NO.             ISSUE DATE
- -----------                                                        ------                 ---------             ----------
<S>                                                                <C>                    <C>                   <C>
Hubert Koster                                                      1,120,000                      1             03-08-95
Hallerstrasse 74
20146 Hamburg, Germany
***                                                                   40,000                      2             03-08-95
***                                                                   20,000                      3             03-08-95
TVM Techno Venture Investors No.1                                      8,000                     10             08-18-95
Limited Partnership
101 Arch Street
Suite 1950
Boston, MA 02110
TVM Techno Venture Investors No.11                                    63,680                     12             08-18-95
Limited Partnership
101 Arch Street
Suite 1950
Boston, MA 02110
TVM Intertech Limited Partnership                                     42,454                     13             08-18-95
101 Arch Street
Suite 1950
Boston, MA 02110
TVM Zweite Beteiligung - U.S.                                         98,000                      6             03-08-95
Limited Partnership
101 Arch Street
Suite 1950
Boston, MA 02110
                                                                      29,360                     11             08-18-95
TVM Eurotech Limited Partnership                                      65,200                      7             03-08-95
101 Arch Street
Suite 1950
Boston, MA 02110
                                                                      19,706                      9             08-18-95
***                                                                   73,600                      8             03-08-95
                  TOTAL:                                           1,580,000
</TABLE>
*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                      SERIES B CONVERTIBLE PREFERRED STOCK
                      ------------------------------------

<TABLE>
<CAPTION>
STOCKHOLDER                                                        SHARES                 CERT. NO.             ISSUE DATE
- -----------                                                        ------                 ---------             ----------
<S>                                                                <C>                    <C>                   <C>
TVM Techno Venture Enterprises No. 11 Limited Partnership            212,267                    B-1              12-22-95
101 Arch Street
Suite 1950
Boston, MA 02110

TVM Intertech Limited Partnership                                    141,513                    B-2              12-22-95
101 Arch Street
Suite 1950
Boston, MA 02110

TVM Zweite Beteiligung-U.S.                                           432,953                    B-3              12-22-95
Limited Partnership
101 Arch Street
Suite 1950
Boston, MA 02110

TVM Eurotech Limited Partnership                                      288,633                   B-4              12-22-95
101 Arch Street
Suite 1950
Boston, MA 02110

TVM Techno Venture Investors No. 1 Limited Partnership                12,634                    B-5              12-22-95
101 Arch Street                                                        6,666                   B-13               2-69-96
Suite 1950
Boston, MA 02110

***                                                                  245,333                    B-6              12-22-95

Alpinvest International B.V.                                         666,667                    B-7              12-22-95
Gooimeer 3
NL- 1410 AB Naarden
The Netherlands

***                                                                  333,333                    B-8              12-22-95

***                                                                   13,333                    B-9               2-29-96
</TABLE>

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

<TABLE>
<CAPTION>
STOCKHOLDER                                                        SHARES                 CERT. NO.             ISSUE DATE
- -----------                                                        ------                 ---------             ----------
<S>                                                                <C>                    <C>                   <C>
***                                                                    6,666                   B-10               2-29-96
***                                                                   66,666                   B-11               2-29-96
***                                                                   20,000                   B-12               2-29-96
***                                                                   33,333                   B-14               2-29-96
***                                                                   33,333                   B-15               2-29-96
Hubert Koster                                                        100,000                   B-16               2-29-96
Hallerstasse 74
20146 Hamburg, Germany
Ernst-Gunter Afting                                                   30,000                   B-17               3-29-96
Maisenweg 21
82152 Krailing
Germany
***                                                                  218,768                   B-18               3-29-96
***                                                                   18,294                   B-19               3-29-96
***                                                                   96,271                   B-20               3-29-96
                  TOTAL:                                           2,976,663
</TABLE>
***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                      SERIES C CONVERTIBLE PREFERRED STOCK
                      ------------------------------------

<TABLE>
<CAPTION>
STOCKHOLDER                                                        SHARES                 CERT. NO.             ISSUE DATE
- -----------                                                        ------                 ---------             ----------
<S>                                                                <C>                    <C>                   <C>
TVM Techno Venture Enterprises No. II                                 76,064                    C-1              05-08-97
Limited Partnership
c/o TVM Techno Venture Management ("TVM")
101 Arch Street, Suite 1950
Boston, MA 02110

TVM Intertech Limited Partnership                                     50,709                    C-2              05-08-97
c/o TVM Techno Venture Management ("TVM")
101 Arch Street, Suite 1950
Boston, MA 02110

TVM Zweite Beteiligung-U.S.                                          152,127                    C-3              05-08-97
Limited Partnership
c/o TVM Techno Venture Management ("TVM")
101 Arch Street, Suite 1950
Boston, MA 02110

TVM Eurotech Limited Partnership                                     101,418                    C-4              05-08-97
c/o TVM Techno Venture Management ("TVM")
101 Arch Street, Suite 1950
Boston, MA 02110

TVM Techno Venture Investors No. 1                                     8,253                    C-5              05-08-97
Limited Partnership
c/o TVM Techno Venture Management ("TVM")
101 Arch Street, Suite 1950
Boston, MA 02110

***                                                                   87,619                    C-6              05-08-97

Alpinvest International B.V.                                         317,460                    C-7              05-08-97
Gooimeer 3
NL- 1410 AB Naarden
The Netherlands
***                                                                   15,873                    C-8              05-08-97
                                                                     222,222                    C-9              05-08-97
***                                                                   16,667                   C-10              05-08-97
***                                                                   16,667                   C-11              05-08-97
</TABLE>

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

<TABLE>
<CAPTION>
STOCKHOLDER                                                        SHARES                 CERT. NO.             ISSUE DATE
- -----------                                                        ------                 ---------             ----------
<S>                                                                <C>                    <C>                   <C>
***                                                                  156,286                   C-12              01-12-98
***                                                                   13,047                   C-13              01-12-98
***                                                                   68,762                   C-14              01-12-98
***                                                                  507,936                   C-15              01-12-98
***                                                                  793,650                   C-16              01-12-98
***                                                                  952,381                   C-17              01-12-98
***                                                                  317,460                   C-18              01-12-98
***                                                                  158,730                   C-19              01-12-98
***                                                                  540,000                   C-__              [CLOSING]
                  TOTAL:                                           4,573,331
</TABLE>
***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                            EXHIBIT 4.2 (CONTINUED)

Sequenom, Inc.
Analysis of stock options and warrants outstanding
as of December 21, 1998

<TABLE>
<CAPTION>
                                                                                                    Exercise
                                                                                      Shares         Price
Issued prior to 1996                                                               -----------    ------------
- ------------------------------------------------------------
<S>                                                                                   <C>              <C>
Hubert Koster (founder)                                                               80,000           $0.05
***                                                                                   30,000           $0.05
***                                                                                   42,000           $0.05
Charles Cantor (technical advisory board)                                             66,000           $0.05
***                                                                                   10,000           $0.05

Issued in 1996
- ------------------------------------------------------------
***                                                                                    1,000           $0.25
Dr. Andreas Braun (employee-1/96)                                                     15,000           $0.25
***                                                                                   10,000           $0.25
***                                                                                    2,000           $0.25
***                                                                                    2,000           $0.25
***                                                                                    3,000           $0.25
Professor Ernst-Gunter Afting (bd member-1/96)                                        20,000           $0.25
***                                                                                    1,000           $0.25
***                                                                                  109,000           $0.25
***                                                                                    5,000           $0.25
John J. DiBello (TVM-9/96)                                                             6,000           $0.25
***                                                                                   18,000           $0.25
***                                                                                   27,000           $0.25

Issued in 1997
- ------------------------------------------------------------
***                                                                                    3,000           $0.25
Steve Zaniboni (employee-6/97)                                                        70,000           $0.25
Dr. Andreas Braun (employee-6/97)                                                     20,000           $0.25
***                                                                                   22,000           $0.25
Dr. Andreas Braun (employee-9/97)                                                     35,000           $0.25
***                                                                                   10,000           $0.25
***                                                                                   10,000           $0.25
***                                                                                    6,000           $0.25
***                                                                                    5,000           $0.25
***                                                                                    3,000           $0.25
***                                                                                    2,000           $0.25
***                                                                                   20,000           $0.25
Hubert Koster (founder-12/97)                                                        300,000           $0.25
Professor Ernst-Gunter Afting (bd member-12/97)                                       20,000           $0.25
Helmut Shuhsler (TVM-12/97)                                                           40,000           $0.25
***                                                                                   41,000           $0.25
***                                                                                   15,000           $0.25
***                                                                                   10,000           $0.25
***                                                                                    3,000           $0.25
***                                                                                    5,000           $0.25
***                                                                                    3,000           $0.25
***                                                                                    3,000           $0.25
***                                                                                    3,000           $0.25
***                                                                                   10,000           $0.25
***                                                                                    6,000           $0.25
</TABLE>
***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

<TABLE>
<CAPTION>
                                                                                                      Exercise
Issued in 1998                                                                       Shares            Price
- --------------                                                                      --------          --------
<S>                                                                                 <C>               <C>
Charles Cantor (technical advisor-4/98)                                                5,000           $0.50
Steve Zaniboni (employee-4/98)                                                        20,000           $0.50
Dr. Andreas Braun (employee-4/98)                                                     50,000           $0.50
***                                                                                   10,000           $0.50
***                                                                                   10,000           $0.50
***                                                                                   10,000           $0.50
***                                                                                   10,000           $0.50
***                                                                                   10,000           $0.50
***                                                                                    3,000           $0.50
***                                                                                    1,500           $0.50
***                                                                                    3,000           $0.50
***                                                                                    1,000           $0.50
***                                                                                    3,000           $0.50
***                                                                                   40,000           $0.50
***                                                                                   20,000           $0.50
***                                                                                    5,000           $0.50
***                                                                                    5,000           $0.50
Charles Cantor (technical advisor-6/98)                                              180,000           $0.50
Steve Zaniboni (employee-6/98)                                                        20,000           $0.50
***                                                                                   10,000           $0.50
***                                                                                    2,000           $0.50
***                                                                                    5,000           $0.50
***                                                                                   20,000           $0.50
***                                                                                   30,000           $0.50
***                                                                                    3,000           $0.50
***                                                                                    5,000           $0.50
***                                                                                   30,000           $0.50
***                                                                                    5,000           $0.50
***                                                                                    5,000           $0.50
Hubert Koster                                                                         75,000           $0.50
***                                                                                   12,000           $0.50
***                                                                                   20,000           $0.50
***                                                                                    1,500           $0.50
***                                                                                    2,500           $0.50
***                                                                                    2,500           $0.50
***                                                                                    1,000           $0.50
***                                                                                    1,000           $0.50
***                                                                                    1,000           $0.50
***                                                                                    5,500           $0.50
***                                                                                      500           $0.50
***                                                                                      500           $0.50
***                                                                                      500           $0.50
***                                                                                      500           $0.50
***                                                                                      500           $0.50
***                                                                                   10,000           $0.50
***                                                                                      500           $0.50
***                                                                                   20,000           $0.50
***                                                                                    3,000           $0.50
***                                                                                   10,000           $0.50
***                                                                                    3,000           $0.50
***                                                                                      500           $0.50
***                                                                                   10,000           $0.50
***                                                                                   10,500           $0.50
***                                                                                      500           $0.50
</TABLE>
***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

<TABLE>
<CAPTION>
                                                                                                      Exercise
Issued in 1998                                                                       Shares             Price
- --------------                                                                      --------          --------
<S>                                                                                 <C>                <C>
***                                                                                   20,000           $0.50
***                                                                                    7,500           $0.50
Hubert Koster (employee-12/98)                                                       180,000           $0.50
***                                                                                  100,000           $0.50
Stephen Zaniboni (employee-12/98)                                                    100,000           $0.50
***                                                                                    5,000           $0.50
***                                                                                    3,000           $0.50
***                                                                                      500           $0.50
***                                                                                    5,000           $0.50
***                                                                                      500           $0.50
***                                                                                    1,000           $0.50
***                                                                                      500           $0.50
***                                                                                    1,000           $0.50
***                                                                                   10,000           $0.50
***                                                                                    3,000           $0.50
Helmut Schusler (bd member-12/98)                                                     20,000           $0.50
***                                                                                   20,000           $0.50
Ernst-Gunter Afting (bd member)                                                       20,000           $0.50
Peter Reinisch (bd member-12/98)                                                      10,000           $0.50
***                                                                                   20,000           $0.50
                                                                                   ---------
                                                                                   =========
Options Outstanding                                                                2,353,000
                                                                                   ---------
***                                                                                   70,000
***                                                                                  106,503
</TABLE>

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                  EXHIBIT 4.3

                               Equity Investments
                               ------------------

     The Corporation has one subsidiary, Sequenom GmbH, approximately all of the
outstanding equity interest in which is owned by the Corporation.
<PAGE>

                                  EXHIBIT 4.4

                          Audited Financial Statements
            as of December 31, 1997 and 1996 and for the period from
               February 14, 1994 (inception) to December 31, 1997
                    with Report of Independent Auditors; and
                         Unaudited Financial Statements
                  for the nine months ended September 30, 1998
                  --------------------------------------------



                                     ***

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.


<PAGE>

                       Consolidated Financial Statements

                                Sequenom, Inc.
                         (a development stage company)

              For the years ended December 31, 1997 and 1996 and
             for the period from February 14, 1994 (inception) to
                               December 31, 1997
                      with Report of Independent Auditors
<PAGE>

                                Sequenom, Inc.
                         (a development stage company)

                       Consolidated Financial Statements

          For the years ended December 31, 1997 and 1996 and for the
        period from February 14, 1994 (inception) to December 31, 1997


                                   CONTENTS

Report of Independent Auditors.............................................   1

Consolidated Financial Statements..........................................

Consolidated Balance Sheets................................................   2
Consolidated Statements of Operations......................................   3
Consolidated Statements of Stockholders' Equity (Deficit)..................   4
Consolidated Statements of Cash Flows......................................   5
Notes to Consolidated Financial Statements.................................   6
<PAGE>

                        Report of Independent Auditors

The Board of Directors
Sequenom, Inc.


We have audited the accompanying consolidated balance sheet of Sequenom, Inc. (a
development stage company) as of December 31, 1997 and the related consolidated
statements of operations, stockholders' equity (deficit), and cash flows for the
year ended December 31, 1997 and the period from February 14, 1994 (inception)
through December 31, 1997.  These consolidated financial statements are the
responsibility of the Company's management.  Our responsibility is to express an
opinion on these consolidated financial statements based on our audit.  The
financial statements as of December 31, 1996, and for the period February 14,
1994 (inception) through December 31, 1996, were audited by other auditors whose
report dated May 15, 1997 expressed an unqualified opinion on those statements.
The financial statements for the period February 14, 1994 (inception) through
December 31, 1996 include total revenues and net loss of $917,994 and
$(6,283,696), respectively.  Our opinion on the statements of operations,
stockholders' equity, and cash flows for the period February 14, 1994
(inception) through December 31, 1997, insofar as it relates to amounts for
prior periods through December 31, 1996, is based solely on the report of other
auditors.

We conducted our audit in accordance with generally accepted auditing standards.
Those standards require that we plan and perform the audit to obtain reasonable
assurance about whether the consolidated financial statements are free of
material misstatement.  An audit includes examining, on a test basis, evidence
supporting the amounts and disclosures in the consolidated financial statements.
An audit also includes assessing the accounting principles used and significant
estimates made by management, as well as evaluating the overall financial
statement presentation.  We believe that our audits and the report of other
auditors provide a reasonable basis for our opinion.

In our opinion, based on our audit and the report of other auditors, the
consolidated financial statements referred to above present fairly, in all
material respects, the financial position of Sequenom, Inc.  ( a development
stage company) at December 31, 1997, and the result of its operations and its
cash flows for the year then ended and the period from February 14, 1994
(inception) through December 31, 1997, in conformity with generally accepted
accounting principles.

                               ERNST & YOUNG LLP


March 13, 1998

                                                                               1
<PAGE>

                                Sequenom, Inc.
                         (a development stage company)

                          Consolidated Balance Sheets

<TABLE>
<CAPTION>
                                                                                                     DECEMBER 31,
                                                                                                 1997            1996
                                                                                             ---------------------------
<S>                                                                                          <C>             <C>
Assets
   Current Assets:
   Cash and cash equivalents                                                                 $    832,782    $ 1,326,137
   Grant receivable                                                                               181,350        241,947
   Refundable value added tax                                                                      57,474         32,922
   Other current assets and prepaid expenses                                                       50,968        140,809
                                                                                             ---------------------------
Total current assets                                                                            1,122,574      1,741,815

Property, equipment and leasehold improvements, net                                             1,002,197        921,034
Organizational costs, net                                                                           9,996         18,000
Other assets                                                                                      137,806         32,834
Total assets                                                                                 $  2,272,573    $ 2,713,683
                                                                                             ===========================

Liabilities and stockholders' equity (deficit)
Current liabilities:
  Accounts payable and accrued expenses                                                      $   1,121971    $   796,662
  Unearned revenue -  current portion                                                             126,000        125,500
                                                                                             ---------------------------
Total current liabilities                                                                       1,247,971        922,162

Unearned revenue -  long term portion                                                                  --        125,500
Accrued long-term interest payable                                                                424,000        274,500
Long-term debt                                                                                  3,348,000      2,597,600

Commitments

Stockholders' equity (deficit):
  Series A Convertible Preferred Stock, $0.001 par value
    1,650,000 shares authorized; 1,580,000 shares issued and outstanding                            1,580          1,580
    (liquidation preference $790,000)

   Series B Convertible Preferred Stock, $0.0001 par value, 2,976,663 shares                        2,977          2,977
       authorized, issued and outstanding (liquidation preference $4,464,995)
   Series C Convertible Preferred Stock, $0.001 par value, 3,365,061 shares                         1,065             --
       authorized; 1,065,079 shares issued and outstanding in 1997 (liquidation
        preference        $3354,999)
   Common Stock, $0.001 par value; 9,218,000 shares authorized; 292,251 and                           292            148
       148,251 shares issue and outstanding in 1997 and 1996, respectively
Additional paid-in capital                                                                      8,569,705      5,229,576
Deferred compensation                                                                                  --        (25,000)
Cumulative translation adjustment                                                                (225,452)      (131,664)
Deficit accumulated in the development stage                                                  (11,097,565)    (6,283,696)
                                                                                             ---------------------------
Total stockholders' equity (deficit)                                                           (2,747,396)    (1,206,079)
                                                                                             ---------------------------
Total liabilities and stockholders' equity (deficit)                                         $  2,272,573    $ 2,713,683
                                                                                             ===========================

See accompanying notes.
</TABLE>
<PAGE>

                                Sequenom, Inc.
                         (a development stage company)

                     Consolidated Statements of Operations


<TABLE>
<CAPTION>
                                                                                                  For the period
                                                                                               from February 14,1994
                                                                                                  (inception) to
                                                               Years ended December 31,             December 31,
                                                       ----------------------------------
                                                            1997                   1996                1997
                                                       -----------            -----------      ---------------------
<S>                                                    <C>                    <C>              <C>
Income:
Research and development grants                        $   526,573            $   892,903          $  1,419,476
Other income                                                88,740                 25,091               113,831
                                                       -----------            -----------          ------------
                                                           615,313                917,994             1,533,307

Operating expenses:
Research and development                                 3,620,298              3,161,296             8,977,847
General and administrative                               1,860,629              1,032,005             3,542,619
                                                       -----------            -----------          ------------
                                                         5,480,927              4,193,301            12,520,466
                                                       -----------            -----------          ------------

Net loss from operations                                (4,865,614)            (3,275,307)          (10,987,159)

Interest income                                             56,986                 72,918               134,964
Interest expense                                          (308,191)              (274,793)             (611,505)
Foreign currency transaction gain                          302,950                 63,185               366,135
                                                       -----------            -----------          ------------
Net loss                                               $(4,813,869)           $(3,413,997)         $(11,097,565)
                                                       ===========            ===========          ============
</TABLE>
See accompanying notes.



                                                                               3
<PAGE>

                                SEQUENOM, INC.
                         (A DEVELOPMENT STAGE COMPANY)
           Consolidated Statements of Stockholders' Equity (Deficit)

      Period from February 14, 1994 (inception) through December 31, 1997

<TABLE>
<CAPTION>
                                      SERIES A CONVERTIBLE    SERIES B CONVERTIBLE   SERIES C CONVERTIBLE
                                        PREFERRED STOCK         PREFERRED STOCK        PREFERRED STOCK        COMMON STOCK
                                      ---------------------------------------------------------------------------------------
                                      Shares        Amount     Shares      Amount    Shares       Amount   Shares      Amount
                                      ---------------------------------------------------------------------------------------
<S>                                   <C>           <C>       <C>          <C>       <C>          <C>      <C>         <C>
Issuance of Common Stock                      -     $    -             -   $    -             -   $    -          -    $  -
Issuance of Series A                    442,000        442             -        -             -        -          -       -
 Convertible Preferred Stock,
 net of issuance costs of
 $35,484
Issuance of Series A                     38,000         38             -        -             -        -          -       -
 Convertible Preferred Stock
 for services
Issuance  of Series A                 1,100,000      1,100             -        -             -        -          -       -
 Convertible Preferred Stock
 for holdings
Translation adjustment                        -          -             -        -             -        -          -       -
Net loss                                      -          -             -        -             -        -          -       -
                                      --------------------------------------------------------------------------------------
Balance at December 31, 1994          1,500,000      1,500             -        -             -        -          -       -
 Issuance of Series B
  Convertible Preferred Stock,
  net of issuance costs of
  $32,940                                     -          -     2,333,333    2,333             -        -          -       -
 Issuance of Common Stock                     -          -             -        -             -        -     26,250      26
 Exercise of Stock Options                    -          -             -        -             -        -    122,000     122
 Translation adjustment                       -          -             -        -             -        -          -       -
 Net loss                                     -          -             -        -             -        -          -       -
                                      --------------------------------------------------------------------------------------
Balance at December 31, 1995          1,500,000      1,500     2,333,333    2,333             -        -    148,251     148
 Issuance of Series B
  Convertible Preferred Stock,
  net of  issuance costs of
  $10,648                                     -          -       643,330      644             -        -          -       -
 Issuance of warrants                         -          -             -        -             -        -          -       -
 Deferred compensation  related               -          -             -        -             -        -          -       -
  to issuance of options to
  consultants
 Translation adjustment                       -          -             -        -             -        -          -       -
 Net loss                                     -          -             -        -             -        -          -       -
                                      --------------------------------------------------------------------------------------
Balance at December 31, 1996          1,500,000      1,500     2,976,663    2,977             -        -    144,251     148
 Exercise of stock options                    -          -             -        -             -        -    144,000     144
 Issuance  of Series C
  Convertible Preferred Stock,
  net of issuance costs of
  $49,661                                     -          -             -        -     1,065,079    1,065          -       -
 Amortization of deferred                     -          -             -        -             -        -          -       -
  compensation
 Translation adjustment                       -          -             -        -             -        -          -       -
 Net loss                                     -          -             -        -             -        -          -       -
                                      --------------------------------------------------------------------------------------
Balance at December 31, 1997          1,500,000     $1,500     2,976,663   $2,977     1,065,079   $1,065    292,251    $292
</TABLE>







<TABLE>
<CAPTION>
                                                                                   DEFICIT
                                                                                ACCOMMODATED        TOTAL
                                      ADDITIONAL                  CUMULATIVE     DURING THE      STOCKHOLDERS'
                                       PAID-IN       DEFERRED     TRANSLATION    DEVELOPMENT        EQUITY
                                       CAPITAL     COMPENSATION   ADJUSTMENT        STAGE         (DEFICIT)
                                      ---------------------------------------------------------------------------------------
<S>                                  <C>           <C>            <C>           <C>              <C>
Issuance of Common Stock             $        -    $      -       $       -     $           -    $         -
Issuance of Series A
 Convertible Preferred Stock,
 net of issuance costs of
 $35,484                                185,074           -               -                 -        185,516
Issuance of Series A
 Convertible Preferred Stock
 for services                            18,962           -               -                 -         19,000
Issuance  of Series A
 Convertible Preferred Stock
 for holdings                           548,908           -               -                 -        550,000
Translation adjustment                        -           -          (1,703)                -         (1,703)
Net loss                                      -           -               -        (1,149,498)    (1,149,498)
                                --------------------------------------------------------------------------------------------
Balance at December 31, 1994            752,937           -          (1,703)       (1,149,498)      (396,684)
 Issuance of Series B
  Convertible Preferred Stock,
  net of issuance costs of
  $32,940                             3,464,727           -               -                 -      3,467,060
 Issuance of Common Stock                 1,287           -               -                 -          1,313
 Exercise of Stock Options                5,978           -               -                 -          6,100
 Translation adjustment                       -           -          (3,222)                -         (3,222)
 Net loss                                     -           -               -        (1,720,201)    (1,720,201)
                                --------------------------------------------------------------------------------------------
Balance at December 31, 1995          4,224,929           -          (4,925)       (2,869,699)     1,354,366
 Issuance of Series B
  Convertible Preferred Stock,
  net of  issuance costs of
  $10,648                               953,647           -               -                 -        954,291
 Issuance of warrants                    10,000           -               -                 -         18,000
 Deferred compensation  related
  to issuance of options to
  consultants                            33,000     (25,000)              -                 -          8,000
 Translation adjustment                       -           -        (126,739)                -       (126,739)
 Net loss                                     -           -               -        (3,413,997)    (3,413,997)
                                --------------------------------------------------------------------------------------------
Balance at December 31, 1996          5,229,576     (25,000)       (131,664)       (6,283,696)    (illegible)
 Exercise of stock options               36,896           -               -                 -      illegible
 Issuance  of Series C
  Convertible Preferred Stock,
  net of issuance costs of
  $49,661                             3,304,273           -               -                 -      3,305,330
 Amortization of deferred
  compensation                                -      25,000               -                 -         25,000
 Translation adjustment                       -           -         (93,788)                -        (93,788)
 Net loss                                     -           -               -        (4,813,869)    (4,813,869)
                                --------------------------------------------------------------------------------------------
Balance at December 31, 1997         $8,569,705     $     -       $(225,452)     $(11,097,565)   $(2,747,398)
</TABLE>
<PAGE>

                                 Sequenom, Inc.
                         (a development stage company)

                     Consolidated Statements of Cash Flows


<TABLE>
<CAPTION>

                                                                                                  For the period from
                                                                 Years ended December 31,          February 14, 1994
                                                       --------------------------------------       to December 31,
                                                                 1997              1996                  1997
                                                       -------------------------------------------------------------
<S>                                                       <C>                    <C>              <C>
Operating activities
Net Loss                                                        $(4,813,869)      $(3,413,997)       $(11,097,565)
Adjustments to reconcile net loss to net cash used in
 operating activities:
         Warrants issued in conjunctions with leasing                     -            18,000              18,000
         Options issued to consultants                               25,000             8,000              33,000
         Stock issued for technology and services                         -                 -             569,000
         Depreciation and amortization                              351,173           314,195             813,333
         Foreign currency transaction gain                         (302,950)                -            (302,950)
         Net change in other assets and liabilities                 348,592           418,737           1,222,242
                                                       ----------------------------------------------------------
Net cash used in operating activities                            (4,392,054)       (2,655,065)         (8,744,940)

Investing activities
Purchase of property and equipment                                 (490,891)         (429,896)         (1,852,085)
Organization costs                                                        -                 -             (40,000)
                                                       ----------------------------------------------------------
Net cash used in investing activities                              (490,891)         (429,896)         (1,892,085)

Financing activities
Proceeds from issuance of Series A Convertible                            -                --             185,516
 Preferred Stock, net of issuance costs of $35,484
Proceeds from issuance of Series B Convertible                            -           954,291           2,841,351
 Preferred Stock, net of issuance cots of $10,648 in
 1996
Proceeds from issuance of Series C Convertible                    3,305,337                 -           3,305,337
 Preferred Stock, net of issuance costs of $49,662
Proceeds from long-term debt                                      1,165,000         1,706,592           3,762,600
Proceeds from issuance of convertible term notes to                       -                 -           1,580,000
 stockholders
Proceeds from issuance of Common Stock                               36,000                 0              43,414
Net cash provided by financing activities                         4,506,337         2,660,883          11,718,218
                                                       ----------------------------------------------------------

Net increase (decrease) in cash                                    (376,608)         (424,078)          1,081,193
Effect of exchange rate change on cash                             (116,747)         (126,739)           (248,411)
Cash and cash equivalents at beginning of period                  1,326,137         1,876,954                   -
Cash and cash equivalents at end of period                      $   832,782       $ 1,326,137        $    832,782
                                                       ----------------------------------------------------------

Supplemental schedule of noncash investing and
 financing activities:
Conversion of convertible term notes to Series B                $         -        $        -        $  1,580,000
 Convertible Preferred Stock
                                                       -------------------------------------------------------------
Supplemental disclosures of cash flow information:
Interest paid                                                   $   158,691        $        -        $    158,691
                                                       -------------------------------------------------------------
See accompanying notes.
</TABLE>

                                                                               5
<PAGE>

                                 Sequenom, Inc.
                          (development stage company)

                   Notes to Consolidated Financial Statements

                               December 31, 1997

1.  NATURE OF THE BUSINESS

Sequenom, Inc. (the "Company") was incorporated on February 14, 1994 in the
State of Delaware.  The Company is focused on developing high definition DNA
analysis tools for industrial biomedical and life science applications.

Since inception, the Company has devoted its efforts to establishing its
business, raising capital and recruiting personnel.  Accordingly, through the
date of these financial statements, the Company is considered to be a
development stage enterprise.

2.  SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Basis of Consolidation

The accompanying consolidated financial statements include the accounts of the
Company and its wholly-owned subsidiary, Sequenom GmbH.  All significant
intercompany transactions have been eliminated in consolidation.

Use of Estimates

The preparation of financial statements in conformity with generally accepted
accounting principles requires management to make certain estimates and
assumptions that affect the reported amounts of assets and liabilities and
disclosure of contingent assets and liabilities at the date of the financial
statements and the reported amounts of revenues and expenses during the
reporting period.  Actual results could differ from those estimates.

Cash and Cash Equivalents

Cash equivalents consists of highly liquid investments with original maturities
when purchased of less than three months.

Concentration of Credit Risk

Financial instruments which potentially subject the Company to concentrations of
credit risk consist of demand deposits.

                                                                               6
<PAGE>

                                 Sequenom, Inc.
                          (development stage company)

            Notes to Consolidated Financial Statements (continued)

2.  SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

Property, Equipment and Leasehold Improvements

Property and equipment are stated at cost and depreciated using the straight-
line method over the estimated useful lives of the assets.  Leasehold
improvements are amortized using the straight-line method over the life of the
improvement or the remaining term of the lease, whichever is shorter.

Organization Costs

Organization costs of $40,000, consisting of legal fees related to the formation
of the Company, are being amortized on the straight-line basis over a five-year
period.

Asset Impairment

The Company adopted Statement of Financial Accounting Standards ("SFAS") No.
121, Accounting for the Impairment of Long-Lived Assets and for Long-Lived
Assets to Be Disposed of, effective January 1, 1996.  SFAS No. 121 requires
impairment losses to be recorded on long-lived assets used in operations when
indicators of impairment are present and the undiscounted cash flows estimated
to be generated by those assets are less than the assets' carrying amount.  SFAS
No. 121 also addresses the accounting for long-lived assets that are expected to
be disposed of.  The adoption had no impact on the Company's financial
statements.

Revenue Recognition

Grant revenue is recorded as the research expenses relating to the grants as
incurred.

Research and Development Costs

Research and development costs are expensed as incurred.

Income Taxes

The Company accounts for income taxes according to SFAS No. 109, Accounting for
Income Taxes.  Under the asset and liability method specified by SFAS No. 109, a
deferred tax asset or liability is determined based on the difference between
the financial statement and tax basis of assets and liabilities as measured by
the enacted tax rates which will be in effect when these differences reverse.


                                                                               7
<PAGE>

                                 Sequenom, Inc.
                          (development stage company)

            Notes to Consolidated Financial Statements (continued)

2.  SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

The Company provides a valuation allowance against net deferred tax assets if,
based upon the available evidence, it is more likely than not that some or all
of the deferred tax assets will not be realized.

Stock-Based Compensation

Effective January 1, 1997, the Company adopted the footnote disclosure
provisions of SFAS No. 123, Accounting for Stock-Based Compensation.  SFAS No.
123 permits entities to adopt a fair value-based method of accounting for stock-
based compensation arrangements, under which compensation cost is determined
using the fair value of the stock option at the grant date and the number of
options vested, and is recognized over the periods in which the related services
are rendered.  However, it also allows an entity to continue measuring
compensation cost for stock-based compensation using the intrinsic value method
of accounting prescribed by Accounting Principles Board Opinion No. 25 ("APB
25"), Accounting for Stock Issued to Employees.  The Company has elected to
continue to apply the provisions of APB 25 and provide pro forma footnote
disclosures required by SFAS No. 123.

Comprehensive Income and Segment Information

In June 1996, the Financial Accounting Standards Board issued SFAS No. 130,
Reporting Comprehensive Income and SFAS No. 131, Disclosure about Segments of an
Enterprise and Related Information.  SFAS No. 130 requires that all components
of comprehensive income be reported in the period in which they are recognized
and is effective for fiscal 1998.  SFAS No. 131 establishes standards for
disclosures of an entity's reportable operating segments, and is also effective
in fiscal 1998.  The Company is in process of evaluating the disclosure
requirements of the new standards, the adoption of which is not expected to have
a material impact on the consolidated financial statements.

Reclassifications

Certain amounts in the prior year financial statements have been reclassified to
conform with current year presentation.

                                                                               8
<PAGE>

                                 Sequenom, Inc.
                          (development stage company)

            Notes to Consolidated Financial Statements (continued)

3.  PROPERTY, EQUIPMENT AND LEASEHOLD IMPROVEMENTS

The following is a summary of property, equipment and leasehold improvements and
related accumulated depreciation and amortization, as of December 31, 1997 and
1996:

                                                       1997           1996
                                                   -------------------------
Laboratory equipment                               $1,248,735     $1,035,924
Leasehold improvements                                119,061        123,236
Office furniture and equipment                        238,418        202,034
                                                   -------------------------
                                                    1,606,214      1,361,194
Less accumulated depreciation and amortization        604,017        440,160
                                                   $1,002,197     $  921,034
                                                   =========================

Total depreciation and amortization expense for the years ended December 31,
1997 and 1996 amounted to $351,173 and $314,195, respectively.

4.  LONG-TERM DEBT

In 1995, the Company and its wholly-owned subsidiary, Sequenom GmbH, entered
into agreements with a  German bank for two loans, one for DM 1 million
(approximately $697,800) and the other for DM 3 million (approximately
$2,093,400).  In 1997, the Company and subsidiary entered into another agreement
with the same German bank for an additional loan of DM 2 million (approximately
$1,116,000).  The loans are unsecured, and must be preceded by an equity
contribution of the same amount by the Company to the subsidiary.  As of
December 31, 997, the Company had made such equity contributions and the
subsidiary had borrowed the entire DM 6 million under the agreements.

Interest is payable semi-annually on the loans.  The 1995 loans began accruing a
nominal interest of 6% on March 31, 1997, while payments commenced in June 1997.
The effective nominal interest rate over the life of the 1995 loans is 4.8%.
The 1997 loan bears interest at 7% with payments commencing in 1998.  The
subsidiary is also required to pay additional interest equal to 9% of the
subsidiary's annual profits, to the extent that such profits exceed DM 100,000
per year.  The combined annual interest rate (nominal interest and additional
interest) may not exceed 7% per year through December 31, 2000.  Commencing
January 1, 2001 and January 1, 2003, any amounts still outstanding will accrue
additional interest at 6% and 7% per annum for the 1995 loans and 1997 loan,
respectively.  Principal is due in full on December 31, 2005 and December 31,
2007 or earlier upon certain events, as defined in the 1995 and 1997 loan
agreements, respectively.


                                                                               9
<PAGE>

                                 Sequenom, Inc.
                          (development stage company)

            Notes to Consolidated Financial Statements (continued)

4.  LONG TERM DEBT (CONTINUED)

In addition, at the end of the loan term (earlier of repayment or December 31,
2005 and December 31, 2007 for the 1995 loans and 1997 loan, respectively), the
subsidiary is obligated to pay a terminal interest equal to 25%, 30% and 35% of
the amounts loaned under the DM I million, DM 3 million and DM 2 million
agreements, respectively, estimated to be $1,0.41,606 u of December 31, 1997.
The bank may elect to forego such payments in certain situations.  The Company
anticipates that the full amount borrowed under these loans will be repaid in
the year 2000.

Under certain conditions, the Company may exercise a "put option" to sell its
shares of capital stock in the subsidiary to the German bank for an amount equal
to 50% of the Company's equity contribution to the subsidiary pursuant to the DM
3 million loan.  Through December 31, 1997, the Company had made capital
contributions to the subsidiary under the DM 3 million loan agreement of DM 3
million (approximately $1,674,000); therefore, the potential amount recoverable
under this "put option" was approximately DM 1.5 million (approximately
$837,000) at December 31, 1997.  If the Company exercises such put option, then
the Series B Preferred Stockholders have a right to elect redemption of their
Series B Preferred Stock in the amount of $1.50 per share.  At the present time
the Company has no intention of exercising the "put option."

5.  STOCKHOLDERS' EQUITY

Pursuant to the Company's Certificate of Incorporation, as amended, the Company
has authorized the issuance of 17,209,744 shares of capital stock par value
$0.001 per share, consisting of 9,218,000 shares of Common Stock ("Common
Stock"), 1,650,000 shares of Series A Convertible Preferred Stock ("Series A
Preferred Stock"), 2,976,663 shares of Series B Convertible Preferred stock
("Series B Preferred Stock"), and 3,365,081 shares of Series C Convertible
Preferred Stock ("Series C Preferred Stock").

All shares of stock have voting rights.  Holders of Common Stock have one vote
per share, while holders of Series A, Series B, and Series C Preferred Stock are
entitled to the number of votes per share equal to the number of shares of
Common stock into which each Preferred share could be converted.

PREFERRED STOCK

Each share of Preferred Stock is convertible into one share of Common Stock at
any time at the option of the holder.  The rate at which the Preferred Stock
convert to Common Stock is subject to adjustment in certain circumstances.  All
outstanding shares of Series C Preferred Stock shall


                                                                              10
<PAGE>

                                 Sequenom, Inc.
                          (development stage company)

            Notes to Consolidated Financial Statements (continued)

5.  STOCKHOLDERS' EQUITY (CONTINUED)

automatically convert to Common Stock upon the closing of a firm commitment
underwritten public offering with a price per share of not less than $9.45 and
with gross proceeds to the Company of not less than $20 million.  All
outstanding shares of Series B and Series A Preferred Stock shall automatically
convert to Common Stock upon the closing of a firm commitment underwritten
public offering with a price per share of not less than $4.50 and $2.50,
respectively, and with gross proceeds to the Company of not less than $10
million.

The holders of the Series B Preferred Stock shall be entitled to receive, from
funds legally available therefore, a noncumulative dividend at the rate of $0.05
per share per annum, payable when and as declared by the Board of Directors.  No
dividends shall be declared or paid to the holders of Series A Preferred Stock
or Common Stock unless the holders of Series B and Series C Preferred Stock have
been paid in full all of the dividends to which they are entitled, nor shall any
dividends be declared or paid to the holders of Series A Preferred Stock or
Common stock at a rate greater than the rate paid to the holders of Series B and
Series C Preferred Stock.  If dividends are paid on Series A or B Preferred
Stock, the holders of the Series C Preferred Stock are entitled to receive a
dividend at the same rate per share.

The Series B and Series C Preferred Stock have preference as to the assets of
the Company upon liquidation over the Series A Preferred Stock and the Common
Stock; the Series A Preferred Stock has preference over the Common Stock.  In
liquidation, the holders of Series B Preferred Stock and Series A Preferred
Stock are entitled to the greater of (a) the amount per share as would have been
payable had all shares of Series B Preferred Stock or Series A Preferred Stock
been converted to Common Stock immediately prior to such event of liquidation,
plus all declared but unpaid dividends or (b) for the Series C preferred stock,
$3.15 per share plus declared but unpaid dividends, for the Series B Preferred
Stock, $1.50 per share plus declared but unpaid dividends and, for the Series A
Preferred Stock, $0.50 per share plus declared but unpaid dividends.

The holders of Series B Preferred Stock have redemption rights under certain
limited conditions as discussed in Note 4.

In December 1995, the Company issued 2,333,333 shares of Series B Convertible
Preferred Stock to a group of investors for gross proceeds of $3,500,000.  In
August 1995 the Company also issued 26,250 shares of Common Stock to one
investor for proceeds of $1,313.

In February 1996, the Company issued 643,330 shares of Series B Convertible
Stock to various investors for gross proceeds of $964,995.


                                                                              11
<PAGE>

                                 Sequenom, Inc.
                          (development stage company)

            Notes to Consolidated Financial Statements (continued)

5.  STOCKHOLDERS' EQUITY (CONTINUED)

In May 1997, the Company issued 1,065,079 shares of Series C Convertible Stock
to various investors for gross proceeds of $3,355,000.

COMMON STOCK

In February 1994, the Company issued 420,000 shares of Common Stock at $0.05 per
share to three individuals (the "founders"), for gross proceeds of $21,000.
These shares were subsequently exchanged for 42,000 shares of Series A Preferred
stock.  In March 1994, the Company issued 380,000 shares of Common Stock, at a
value of $0.05 per share, which were subsequently exchanged for 38,000 shares of
Series A Preferred Stock, to one of the founders for consulting services.  The
Company recorded expense of $19,000 related to this issuance of shares.

In May 1994, the Company issued 400,000 shares of Common Stock at $0.50 per
share to a group of investors for gross proceeds of $200,000.  Contemporaneously
with this issuance of shares, the Company issued 1,100,000 shares of Common
Stock at a value of $0.50 per share to one of the founders in exchange for the
assignment of the rights to all inventions (and related documentation) which had
been developed by the founder.  Accordingly, $550,000 has been recorded as
research and development expense in the accompanying financial statements.
These shares were subsequently exchanged for 400,000 shares and 1,100,000 shares
of Series A Preferred Stock, respectively.

1994 STOCK PLAN

In February 1994, the Company adopted the 1994 Stock Plan (the "Plan").  The
Plan provides for the grant of options to purchase Common Stock and the issuance
of shares of Common Stock subject to Company repurchase rights to directors,
officers, employees and consultants to the Company.  Options granted to
employees generally vest over four years at the rate of 25% per year with a
maximum term of 10 years.  Options granted to consultant shave vesting periods
determined at the date of grant.  The number of shares of Common Stock issuable
under the Plan was 1,700,000 in 1997 and 1,000,000 in 1996.


                                                                              12
<PAGE>

                                 Sequenom, Inc.
                          (development stage company)

            Notes to Consolidated Financial Statements (continued)

5.  STOCKHOLDERS' EQUITY (CONTINUED)

The stock option activity is summarized as follows:

                                        Number of        Weighted
                                         Shares           Average
                                                       Exercise Price
                                    ---------------------------------
Balance at December 31, 1993
  Granted                                318,000            $0.50
  Canceled                                    --               --
  Exercised                                   --               --
                                       ---------
Balance at December 31, 1994              318,00            $0.50
  Granted                                370,000            $0.05
  Canceled                              (318,000)           $0.50
  Exercised                             (122,000)           $0.05
                                       ---------
Balance at December 31, 1995             248,000            $0.05
  Granted                                435,000            $0.25
  Canceled                                    --               --
  Exercised                                   --               --
                                       ---------
Balance at December 31, 1996             683,000            $0.18
  Granted                                731,000            $0.25
  Canceled                               (50,000)           $0.25
  Exercised                             (144,000)           $0.25
  Balance at December 31, 1997         1,220,000            $0.21
                                       =========

At December 31, 1997, 214,000 shares were available for future option grants and
1,434,000 shares of Common Stock were reserved for issuance of all options.

The following table summarizes information about options outstanding at December
31, 1997:

                          OPTIONS OUTSTANDING          OPTIONS EXERCISABLE
                      ---------------------------    ----------------------
                                        WEIGHTED
                                         AVERAGE                   WEIGHTED
                                        REMAINING                   AVERAGE
     RANGE OF          NUMBER         CONTRACTUAL      NUMBER      EXERCISE
  EXERCISE PRICE     OUTSTANDING          LIFE       EXERCISABLE    PRICE
- ---------------------------------------------------  -----------   --------
        $0.05           248,000           7.3          82,000       $0.05
        $0.25           972,000           9.5          84,250       $0.25
- -------------         ---------                      --------
$0.05 - $0.25         1,220,000           9.1         166,250       $0.15
=============         =========                      ========


                                                                              13
<PAGE>

                                 Sequenom, Inc.
                          (development stage company)

            Notes to Consolidated Financial Statements (continued)

5.  STOCKHOLDERS' EQUITY (CONTINUED)

Of the 731,000 options issued in 1997, 3,000 were exercisable in full on the
date of grant with the remaining exercisable ratably over a four-year period.
Of the 435,000 options issued in 1996, 67,000 were exercisable in full on the
date of grant, 36,000 were exercisable ratably over a six-month period and the
remaining 332,000 were exercisable over a five year period.  Of the 370,000
options issued in 1995, 222,000 were exercisable in full on the date of grant,
30,000 were exercisable ratably over a five-year period and an additional
118,000 are subject to a vesting schedule as follows - 22,000 became immediately
exercisable and 96,000 are exercisable on the earlier of November 1, 2003, or
the achievement of certain milestones, as defined.  None of these milestones had
been achieved as of December 31, 1997.

The Company accounts for the stock option plan under APB No. 25, under which no
compensation cost has been recognized.  Had compensation cost for this plan been
determined consistent with SFAS No. 123, the Company's net loss would have been
changed to the following pro forma amounts:

                                             1997                1996
                                    ------------------------------------
  Adjusted pro forma net loss            $(4,819,703)       $(3,416,437)

Pro forma information regarding net loss has been determined as if the Company
has accounted for its employee stock options under the fair value method
prescribed in SFAS No. 123.  The fair value of these options was estimated at
the date of grant using the minimal value pricing model with the following
weighted average assumptions for 1997 and 1996: risk-free interest rate of 6%;
dividend yield of 0%; and a weighted-average life of the option of four years.

The minimal value pricing model is similar to the Black-Scholes option valuation
model which was developed for use in estimating the fair value of traded options
which have no vesting restrictions and are fully transferable, except that it
excludes the factor for volatility.  In addition, option valuation models
require the input of highly subjective assumptions.  Because the Company's
employee stock options have characteristics significantly different from those
of traded options, and because changes in the subjective input assumptions can
materially affect the fair value estimate, in management's opinion, the existing
models do not necessarily provide a reliable single measure of the fair value of
its employee stock options.


                                                                              14
<PAGE>

                                 Sequenom, Inc.
                          (development stage company)

            Notes to Consolidated Financial Statements (continued)

6.  INCOME TAXES

Deferred income taxes reflect the net effects of temporary differences between
the carrying amounts of assets and liabilities for financial reporting purpose
and the amounts used for income tax purposes.  Significant components of the
Company's deferred tax assets are shown below.  A valuation allowance of
$4,621,000 has been recognized as realization of such assets is uncertain.

                                                        December 31,
                                                    1997            1996
                                               ----------------------------
Deferred tax assets:
  Net operating loss carryforwards             $ 3,383,000      $ 1,408,000
  Research and development credits                 193,000           46,000
  Capitalized research expenses                    981,000          830,000
  Other, net                                        64,000               --
                                               ----------------------------
Total deferred tax assets                        4,621,000        2,284,000
Valuation allowance                             (4,621,000)      (2,284,000)
                                               ----------------------------
Net deferred tax assets                        $        --      $        --
                                               ============================

At December 31, 1997, the Company has federal and state tax net operating loss
carryforwards of approximately $4,710,000 and $2,344,000, respectively.  The
difference between the federal and state tax loss carryforwards is attributable
to the capitalization of research and development expenses for state tax
purposes.  The federal and state tax loss carryforwards will begin to expire in
2008 and 1998, respectively, unless previously utilized.  The Company also has
German net operating loss carryforwards of approximately $2,990,000 which may be
carried forward indefinitely.  The Company also has federal and state research
and development tax credit carryforwards of approximately $154,000 and $59,000
respectively, which will being to expire in 2011 unless previously utilized.

Pursuant to Internal Revenue Code Sections 382 and 383, use of the Company's net
operating loss and credit carryforwards may be limited if a cumulative change in
ownership of more than 50% occurs within a three-year period.

7.  Commitments

Leases

In October 1994, the Company entered into a master lease agreement whereby it
may lease up to $1 million of equipment over a period of three years.  The
Company has made deposits of $52,100 ($14,300 by the Company and DM 54,300 by
the Company's subsidiary) in connection with this arrangement.  Additionally,
under the terms of this



                                                                              15
<PAGE>

                                 Sequenom, Inc.
                          (development stage company)

            Notes to Consolidated Financial Statements (continued)

7.  COMMITMENTS (CONTINUED)

agreement, in 1996 the Company issued warrants to purchase 70,000 shares of
Series A Preferred Stock at an exercise price of $0.50 per share.  In connection
with those warrants, the Company recorded $18,000 of expense in 1996.  The
initial delivery of equipment under this arrangement was made to the Company's
subsidiary in December 1994.  The lease extends through June 1998.  Total rent
expense under this lease was approximately $199,000 in 1997 and $180,000 in
1996.

The Company entered into a lease of office and research and development space in
1996 which commenced on April 1, 1997 and extends through March 2000.  Prior to
that date, the Company had been subject to a short-term lease agreement for such
space commencing in October 1996, and incurred approximately $132,000 of rent in
1997 and $34,000 in 1996.  The Company's subsidiary entered into a lease of
office and research and development space in 1995 extending until July 2000.
Total rent expense under this lease was approximately $118,000 in 1997 and
$68,000 in 1996.

Future commitments under operating leases at December 31, 1997 are approximately
as follows:

                         1998                  $  484,000
                         1999                  $  425,000
                         2000                  $  148,000
                                               ----------
                                               $1,057,000
                                               ==========

Consulting Agreements

The Company has entered into agreements with consultants to provide scientific
and management services.  One agreement is with a board member for strategic
consulting services.  This agreement expired in June 1997, and provided for
payment of $1,500 per day and stock options for 72,000 shares of Common Stock.
The Company valued these options at $9,000.  This expense was recognized over
the vesting period.  Payments under this agreement amounted to approximately
$90,750 and $121,000 in 1997 and 1996, respectively.

The Company has also entered into consulting agreements with two individuals for
scientific advisory services.  Each individual receives a fee of $20,00 per
year, and has been granted a certain number of nonqualified stock options, which
vest upon the later of the occurrence of one or more events or ten years.  The
Company valued these options at $24,000.  This expense was recognized over the
period of service under the contracts.  These agreements exist on a quarter-to-
quarter basis and are cancelable by either the Company or the individual upon
thirty days written notice.


                                                                              16
<PAGE>

                                 Sequenom, Inc.
                          (development stage company)

            Notes to Consolidated Financial Statements (continued)

7.  COMMITMENTS (CONTINUED)

Development Agreements

In August 1994, the Company entered into a development agreement with a
university for the design and construction of a prototype DNA sequencing mass
spectrometer.  Payments amounted to approximately $203,200 and $270,000 for the
period ending June 1997 and June 1996, respectively.  In September 1997, the
Company extended the agreement through June 30, 1999 and committed to a payment
approximately $200,000 for the two year period ending June 30, 1998.

In September 1994, the Company entered into a development agreement with another
university for the design of a system for preparation of DNA samples.  Payments
under the agreement were approximately $112,000 in 1997 and $150,000 in 1996.
The Company is committed to a payment of approximately $220,000 for 1998.

8.  GERMAN GOVERNMENT GRANTS

The Company's wholly owned subsidiary, Sequenom GmbH, has been the recipient of
two grants from German government authorities.  The first grant, received in
1996 from the City/State of Hamburg, is for DM 800,000 (approximately $520,000).
This grant reimburses the subsidiary for the cost of certain equipment to be
used in a three-year research project.  If the equipment is not used for the
grant's express purpose, the equipment must be relinquished to the City/State of
Hamburg.  Through December 31, 1997, approximately DM 609,000 (approximately
$377,000) of such equipment had been purchased under the grant program.
Deferred revenue at December 31, 1997 relating to the grant totaled DM 224,000
($126,000).

The second grant, also received in 1996, is from the German Federal Ministry of
Research and Development and amounts to DM 2.2 million (approximately $1.4
million).  This grant reimburses the Company for certain materials, personnel,
travel and development costs.  Through December 31, 1997, approximately DM
1,844,000 (approximately $1,169,000) had been expended and recognized under this
grant program.

                                                                              17
<PAGE>

                                 Sequenom, Inc.
                          (development stage company)

            Notes to Consolidated Financial Statements (continued)

9.  YEAR 2000 ISSUE (UNAUDITED)

The Company recognizes the need to ensure that its operations will not be
adversely impacted by Year 2000 hardware and software issues.  The Company
intends to confirm its compliance regarding Year 2000 issues for both internal
and external information systems by the end of 1998.  This process will entail
communications with significant suppliers, financial institutions, insurance
companies and other parties that provide significant services to the Company.
Expenditures required to make the Company Year 2000 compliant will be expensed
as incurred and are not expected to be material to the Company's financial
position or results of operations.

10.  SUBSEQUENT EVENTS

Series C Preferred Stock

In January 1998, the Company issued an additional 2,968,252 shares of Series C
Preferred Stock at $3.15 per share for gross proceeds of $9,349,998.

Long-Term Convertible Debt

In January 1998, the Company entered into an agreement with a German bank for
debt of DM 4 million (approximately $2,285,000) which is convertible into Common
Stock.  Interest is equal to 6% of the subsidiary's annual profits.  However,
the combined annual interest rate on all loans granted by the same German bank
(see Note 4) may not exceed 9% of the subsidiary's annual profits or the
combined annual interest rate on all loans with the German bank may not exceed
7%.  The loan may be converted to Common Stock each June or December at the
option of the bank.  The conversion ratio is calculated as the arithmetic mean
between $3.15 per share and a current valuation of the Common Stock at the time
of conversion, not to exceed $8.40 per share.  The loan must be repaid by
December 31, 2007, if not previously converted.

Sequenom GmbH Financing

In February 1998, a German bank purchased 2,700 shares of approximately 5% of
Sequenom GmbH common stock for DM 3 million (approximately $1,714,000).  These
shares can be converted to Sequenom, Inc.'s Series C Preferred Stock at the
option of the bank.  The conversion price is $3.15 per share.  Sequenom, Inc.
can call for conversion in the case of an initial public offering or the exit of
existing investors.

Equipment Lease Line

In February 1998, the Company entered into a $1,500,000 equipment lease
agreement.  Under the agreement, the lessor will purchase equipment which the
Company will lease and make monthly payments for over a 42-month period with a
2.72% monthly interest rate.


                                                                              18
<PAGE>

                                 Sequenom, Inc.
                          Consolidated Balance Sheets

<TABLE>
<CAPTION>
                                     Sept 30,      Dec 31,                                                Sept 30,       Dec 31,
                                       1998         1997                                                    1998           1997
                                    (Unaudited)                                                          (Unaudited)
                                    ----------    ---------                                              ----------    -----------
<S>                                 <C>           <C>         <C>                                        <C>           <C>
Cash                                   ***          832,782     Accounts payable & accrued expenses         ***          1,121,972
Accounts receivable                         --           --     Unearned revenue - current portion           --            126,000
Other currents assets                  ***          289,792     Capital lease - current portion             ***
                                    ----------    ---------                                              ----------    -----------
Total Current Assets                   ***        1,122,574        Total Current Liabilities                ***          1,247,972
Property, equipment and leasehold      ***        1,002,197     Capital lease - long-term portion           ***
 Improvements, net
Organization costs, net                     --        9,996     Accrued interest                            ***            424,000
Other assets                           ***          137,806     Long-term debt                              ***          3,348,000
                                                                                                         ----------    -----------
                                                                   Total Long-Term Liabilities              ***          3,772,000
                                                                      Total Liabilities                     ***          5,019,972
                                                                Common and preferred stock                  ***              5,914
                                                                Additional paid in capital                  ***          8,569,704
                                                                Accumulated deficit                         ***        (11,097,585)
                                                                Cumulative translation adjustment           ***           (225,452)
                                                                                                         ----------    -----------
                                                                   Total Equity                             ***         (2,747,399)
                                    ----------    ---------           Total Liabilities &                ----------    -----------
                                       ***        2,272,573           Stockholders' Equity                  ***          2,272,573
                                    ==========    =========                                              ==========    ===========

</TABLE>
   ***  Portions of this page have been omitted pursuant to a request for
        Confidential Treatment and filed separately with the Commission.

                                    Interim
<PAGE>

                                 Sequenom, Inc.
                      Consolidated Statement of Operations

<TABLE>
<CAPTION>
                                                                         Nine Months
                                                                            Ended          Year Ended
                                                                          30-Sep-98        31-Dec-97
                                                                      -------------        -----------
                                                                         (Unaudited)
<S>                                                                   <C>                  <C>
Research & development grants                                                ***               526,573
Other Income                                                                  --                88,740
                                                                      ----------           -----------
                                                                             ***               615,313
Operating expenses:
Research and development                                                     ***             3,620,298
General and administrative                                                   ***             1,860,629
                                                                      ----------           -----------
                                                                             ***             5,480,927

Net loss from operations                                                     ***            (4,865,614)

Interest income                                                              ***                56,986
Interest expense                                                             ***              (308,191)
Foreign currency transaction (loss) gain                                     ***               302,950
                                                                      ----------           -----------
Net loss                                                                     ***            (4,813,869)
</TABLE>
  ***   Portions of this page have been omitted pursuant to a request for
        Confidential Treatment and filed separately with the Commission.

                                    Interim
<PAGE>

                                  EXHIBIT 4.5

                            Undisclosed liabilities
                            -----------------------

     See Exhibit 4.14.
         ------------
<PAGE>

                                  EXHIBIT 4.6

                        Changes Since September 30, 1998
                        --------------------------------

     See Exhibit 4.14.
         ------------
<PAGE>

                                  EXHIBIT 4.7

                                  Encumbrances
                                  ------------

     None, other than non-consensual liens arising in the ordinary course of
business by operation of law and assets capitalized under an equipment lease
line agreement.  The Corporation is not aware of the existence of any such
liens.
<PAGE>

                                  EXHIBIT 4.8

                        Patents and Patent Applications
                        -------------------------------





                                     ***

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                  EXHIBIT 4.13

                              Material Agreements
                              -------------------

ITEM 4.13 (c)

    1.  Employment agreement dated September 6, 1996 between Sequenom, Inc. and
Fareed Kureshy.

    2.  Consulting Agreement dated September 6, 1996 between Sequenom, Inc. and
Dr. Hubert Koster; Executive Employment Agreement dated April 1, 1994 between
Sequenom, Inc. and Dr. Hubert Koster.

    3.  Scientific Advisory Board Agreement dated September 6, 1996 between
Sequenom, Inc. and Dr. Hubert Koster.

    4.  Consulting Agreement dated December 16, 1996 between Sequenom, Inc. and
Thomas A. Bologna.

    5.  Consulting Services Agreement dated April 1, 1994 between Sequenom,
Inc. and Charles Cantor.

    6.  Consulting Services Agreement dated April 1, 1994 between Sequenom,
Inc. and Robert Cotter.

    7.  Consulting Services Agreement dated October 4, 1996 between Sequenom,
Inc. and Prof. Dr. Franz Hillenkamp.

    8.  Consulting Services Agreement dated February 17, 1997 between Sequenom,
Inc. and Prof. Dr. Ulf B. Gobel.

    9.  Severance Agreement dated May 23, 1997 between Sequenom, Inc. and Fareed
Kureshy.

   10.  Amendment dated June 9, 1997 to the Consulting Agreement between
Sequenom, Inc. and Thomas Bologna.

   11.  Consulting Agreement dated January 30, 1997 between Sequenom, Inc. and
Prof. Dr. Peter Roepstorff.

   12.  Consulting Agreement dated August 24, 1997 between Sequenom, Inc. and
Dr. Kris Venkat.

   13.  Indemnification Agreement dated December 23, 1997 between Sequenom, Inc.
and Thomas A. Bologna concerning Mr. Bologna's service as a director.

   14.  Indemnification Agreement dated December 23, 1997 between Sequenom, Inc.
and William Golden concerning Mr. Golden's service as a director.
<PAGE>

    15.  Employment Agreement dated July 1, 1997 between Sequenom, Inc. and Dr.
Hubert Koster.

    In addition, the Corporation is in the process of negotiating the following
agreements:

    (a)  Employment Agreement between Sequenom, Inc. and Dr. Charles Cantor.

    (b)  Employment Agreement between Sequenom, Inc. and Dr. Toni Schuh.


ITEM 4.13 (d)

    1.  The Corporation maintains the 1994 Stock Plan.  The Plan provides for
the grant of options to purchase Common Stock and the issuance of shares of
Common Stock to employees, officers, directors and consultants to the
Corporation.  The 1994 Stock Option Plan remains in effect pending adoption of
the 1998 Stock Option Plan.

    2.  The Corporation provides health and dental insurance to all of its
full-time employees through a policy with the Guardian Insurance Company.


ITEM 4.13 (e)

    1.  Grid Promissory Note dated March 21, 1997 for up to DM 5,000,000
between the Corporation and its wholly-owned subsidiary, Sequenom Instruments
GmbH.

    2.  "Kooperationsvertrag" (Cooperation Agreement) between Sequenom, Inc.
and Technologie Beteiligung Gesellschaft mbH der Deutschen Ausgleichsbank
("tbg") related to a silent partnership loan of DM 1 million to the company's
wholly-owned subsidiary Sequenom Instruments GmbH dated May 1995.

    3.  "Kooperationsvertrag" (Cooperation Agreement) between Sequenom, Inc.
and Technologie Beteiligung Gesellschaft mbH der Deutschen Ausgleichsbank
("tbg") related to a silent partnership loan of DM 3 million to the company's
wholly-owned subsidiary Sequenom Instruments GmbH dated December 1995.

    4.  "Kooperationsvertrag" (Cooperation Agreement) between Sequenom, Inc.
and Technologie Beteiligung Gesellschaft mbH der Deutschen Ausgleichsbank
("tbg") related to a silent partnership loan of DM 2 million to the company's
wholly-owned subsidiary Sequenom Instruments GmbH dated October 1997.


ITEM 4.13 (g)

    1.  Global Master Rental Agreement between Sequenom, Inc. and Comdisco, Inc.

    2.  Standard Industrial Gross Lease for office and development space in San
Diego between Sequenom, Inc. and Sorrento Business Complex.

    3.  Master Equipment Lease Agreement dated February 5, 1998 between
Sequenom, Inc. and Phoenix Leasing Incorporated.
<PAGE>

     4.  Amendment No. 1 dated September 16, 1998 to the Master Equipment Lease
Agreement dated February 5, 1998 between Sequenom, Inc. and Phoenix Leasing
Incorporated.


ITEM 4.13 (i)

     1.  Sponsored Research Agreement dated September 15, 1994 between Sequenom,
Inc. and the Trustees of Boston University.

     2.  Termination Letter dated February 5, 1997 with respect to the Sponsored
Research Agreement dated September 15, 1994 between Sequenom, Inc. and the
Trustees of Boston University.

     3.  Research Agreement dated October 1, 1994 between Sequenom, Inc. and the
Johns Hopkins University.

     4.  Amendment No. 1 dated October 23, 1995 to Research Agreement dated
October 1, 1994 between Sequenom, Inc. and the Johns Hopkins University.

     5.  Patent and Know-How License Agreement dated June 1, 1996 between
Sequenom, Inc. and the Trustees of Boston University.

     6.  Patent Sublicense Agreement dated November 19, 1996 between Sequenom,
Inc. and Protogene Laboratories, Inc.

     7.  Confidentiality/Material Transfer Agreement dated December 1, 1995
between Sequenom, Inc. and Becton, Dickinson and Company.

     8.  Sponsored Research Agreement dated July 1, 1996 between Sequenom, Inc.
and the Korea Advanced Institute of Science and Technology ("KAIST").

     9.  License Agreement between Sequenom, Inc. and the Johns Hopkins
University, as contemplated by item 3 above (negotiated but not yet executed by
the parties).

     10.  Letter extending the term of the Sponsored Research Agreement dated
July 9, 1997 between Sequenom, Inc. and KAIST.

     11.  Agreement dated October 8, 1997 between Sequenom, Inc. and Community
Technology Fund, Office of Technology Transfer of Community Technology Fund and
Center for Advanced Biotechnology of Boston University.

                                    *  *  *

     12.  The Corporation's wholly-owned subsidiary, Sequenom Instruments GmbH,
has the following material agreements relating to loans and grants:

          .  Beteiligungsvertrag (Investment Contract) between Sequenom
     Instruments GmbH and Technologie Beteiligung Gesellschaft mbH der Deutschen
     Ausgleichsbank ("tbg") for a silent partnership loan of DM 1 million dated
     May 1995.
<PAGE>

         .  Beteiligungsvertrag (Investment Contract) between Sequenom
    Instruments GmbH and Technologie Beteiligung Gesellschaft mbH der Deutschen
    Ausgleichsbank ("tbg") for a silent partnership loan of DM 3 million dated
    December 1995.

         .  Zuwendung aus dem Bundeshaushalt (Federal Budget Grant) dated
    August 17, 1995 for the co-operative project "High Speed DNA Sequencing and
    DNA Diagnostics with the Help of Mass Spectrometry" from the
    Bundesministerium flur Bildung, Wissenschaft, Forschung und Technologie (the
    Ministry for Education, Science, Research and Technology) in the amount of
    DM 2.2 million.

         .  Foderantrag (Grant Application) for the period October 1, 1995 to
    December 31, 1998 for the co-operative project High Speed DNA Sequencing and
    DNA Diagnostics with the Help of Mass Spectrometry with the Freie und
    Hansestadt Hamburg Wirtschaftbehorde (the Trade Bureau of the City/State of
    Hamburg) in the amount of DM 800,000.
<PAGE>

                                  EXHIBIT 4.14

  Compliance with State Securities Laws in connection with Stock Option Grants
  ----------------------------------------------------------------------------


     The Corporation granted stock options to various individuals between the
dates of  February, 1994 and September, 1998 under the Corporation's 1994 Stock
Plan (the "Plan").  The shares of the Corporation's Common Stock that are
subject to the grants were not qualified or exempted under applicable state
securities laws and therefore the options may have been granted in violation of
such laws.  As a result, the Corporation may have potential liability to some or
all of the individuals to whom the options were granted.  The Corporation is
currently analyzing this matter and cannot, at this time, ascertain the extent
of its potential liability, if any.  Nevertheless, the Corporation does not
believe that such potential liability, if any, would exceed $200,000 in the
aggregate.
<PAGE>

                                  EXHIBIT 4.l5

                                   Insurance
                                   ---------

     See Exhibit 4.13 and the following:
         ------------

1.   St. Paul Fire and Marine Insurance Company
     Policy Period: October 26, 1998 - October 25, 1999
     Premium: $5,980
     Policy Number: FK06603871

     Commercial General Liability Limits:

<TABLE>
         <S>                                                                                <C>
         Each Event:                                                                                    $2,000,000
         Premises Damage:                                                                               $1,000,000
         Medical Expenses:                                                                              $    5,000
         Personal Injury and Advertising Injury:                                                        $2,000,000
         Aggregate Limit:                                                                               $4,000,000

         Loss of Earnings and Extra Expenses Coverage, Limit:                                           $  500,000

         Specialized Medical & Computer Equipment:                                                      $1,000,000

         Hired and non-owned Auto Liability:                                                            $2,000,000

         Subject to $500 deductible:
         Business Contents:                                                                             $1,000,000
         Valuable Papers                                                                                $   25,000
         Account Receivable                                                                             $   25,000
         Money and Securities (Inside & Outside)                                                        $   12,000
</TABLE>

2.   Zenith Insurance Company
     Policy Period: October 1, 1998 - October 1, 1999
     Premium: $6,143
     Policy number: Z042591702

         <TABLE>
         <S>                                                             <C>
         Workers Compensation Insurance
         Employers Liability Insurance Limits:
         Bodily Injury by Accident:                                      $1,000,000 each accident
         Bodily Injury by Disease:                                       $1,000,000 each employee
         Bodily Injury by Disease                                        $1,000,000 policy limit

</TABLE>
<PAGE>

3.   Woodruff - Sawyer & Co. - Insurer: 100% Lloyd's of London
     Policy Period: October 7, 1998 - October 7, 1999
     Premium: $16,536
     Policy number: DOM3000604
     Directors & Officers Liability
     Limit(s): $2,000,000

4.   The Corporation also maintains life insurance coverage on Dr. Hubert Koster
     in the amount of $1,000,000 ($500,000 in whole life and $500,000 in term
     life).  The Corporation is beneficiary of both policies.
<PAGE>

                                 EXHIBIT 4.16A

                     Form of Registration Rights Agreement
                     -------------------------------------
<PAGE>

                              AMENDED AND RESTATED
                         REGISTRATION RIGHTS AGREEMENT

     This Amended and Restated Registration Rights Agreement (this "Agreement")
is entered into as of December 21, 1998 by and among Sequenom, Inc., a Delaware
corporation (the "Corporation"); the holders (the "Series B Investors") of
shares of the Corporation's Series B Convertible Preferred Stock, $.001 par
value per share (the Series B Preferred Stock"); the holders (the "Series C
Investors") of shares of the Corporation's Series C Convertible Preferred Stock,
$.001 par value per share (the "Series C Preferred Stock"); and the purchasers
of shares of the Corporation's Series D Convertible Preferred Stock, par value
$.001 per share (the "Series D Preferred Stock"), pursuant to the Series D
Convertible Preferred Stock Purchase Agreement dated as of the date hereof (the
"Purchase Agreement"), including any Additional Investors as defined in the
Purchase Agreement (such purchasers of Series D Preferred Stock being
hereinafter sometimes referred to individually as an "Investor" and collectively
as the "Investors").

     WHEREAS, the Corporation, the Series B Investors and the Series C Investors
are the parties to a Registration Rights Agreement dated as of May 8, 1997, as
amended as of January 12, 1998 (the "Prior Registration Rights Agreement"),
pursuant to which the Corporation granted certain registration rights to the
Series B Investors, the Series C Investors and certain of their transferees;

     WHEREAS, the Corporation now wishes to sell to the Investors certain shares
of its Series D Preferred Stock;

     WHEREAS, the Series B Preferred Stock, the Series C Preferred Stock and the
Series D Preferred Stock are convertible into shares of the Corporation's Common
Stock; and

     WHEREAS, as a condition to entering into the Purchase Agreement, the
Investors have required that the Corporation, the Series B Investors and the
Series C Investors execute this Agreement to provide the Investors rights to
register the shares of Common Stock issuable upon conversion of their Series D
Preferred Stock and certain other securities of the Corporation described below;

     NOW, THEREFORE, in consideration of the premises and the mutual agreements
hereinafter set forth, the parties hereto agree as follows:

     1.  Definitions.  As used in this Agreement, the following terms shall have
         -----------
the following meanings:

         (a) The term "Act" means the Securities Act of 1933, as amended;
                                      ----------

         (b) The term "Holder" means any Investor, any Series B Investor, any
                                         --------
Series C Investor and any other person or entity holding Registrable Securities
to whom the registration rights granted in this Agreement have been transferred
pursuant to Section 14 hereof;

         (c) The term "Preferred Stock" means the Series B Preferred Stock, the
Series C Preferred Stock and the Series D Preferred Stock;
<PAGE>

         (d) The terms "register," "registered," and "registration" refer to a
registration effected by preparing and filing a registration statement in
compliance with the Act and the declaration or ordering of effectiveness of such
registration statement; and

         (e) The term "Registrable Securities" means (1) the Common Stock
issuable upon conversion of the Preferred Stock, (2) Common Stock purchased by
an Investor pursuant to Section 8.1 of the Purchase Agreement (or Common Stock
for or into which New Securities (as therein defined) purchased by the Investor
pursuant to such Section 8.1 may be exercised or converted) or pursuant to the
Stock Restriction Agreement dated as of the date hereof among the Corporation,
the Series B Investors, the Series C Investors, the Investors and certain
additional parties identified therein, and (3) any Common Stock of the
Corporation issued as a dividend or other distribution with respect to, or in
exchange or in replacement of, such Preferred Stock or Common Stock.

     In addition, for purposes of all calculations and notices under this
Agreement, and all other provisions of this Agreement where the context permits,
the term "Registrable Securities" shall include securities issuable upon
conversion of the Preferred Stock, a holder of the Preferred Stock shall be
deemed the Holder of such securities and such securities shall be deemed
outstanding Registrable Securities hereunder.  Notwithstanding the foregoing,
nothing in this Agreement shall require the Corporation actually to register any
shares of the Preferred Stock.

     2.  Request for Registration.  If at any time after the earlier of (i) the
         ------------------------
first underwritten public offering of securities for the account of the
Corporation, and (ii) the date two (2) years from the date hereof, the
Corporation shall receive a written request (specifying that it is being made
pursuant to this Section 2) from the Holder or Holders at least fifty percent
(50%) of the then outstanding Registrable Securities that the Corporation file a
registration statement under the Act, or a similar document pursuant to any
other statute then in effect corresponding to the Act, covering the registration
of at least the lesser of (i) at least twenty-five percent (25%) of the then
outstanding Registrable Securities and (ii) Registrable Securities the expected
price to the public of which equals or exceeds $10,000,000, then the Corporation
shall promptly notify all other Holders of such request and shall use its best
efforts to cause all Registrable Securities that Holders have requested be
registered to be registered under the Act.

     Notwithstanding the foregoing, (a) the Corporation shall not be obligated
to effect a registration pursuant to this Section 2 during the period starting
with the date sixty (60) days prior to the Corporation's estimated date of
filing of, and ending on a date six (6) months following the effective date of,
a registration statement pertaining to an underwritten public offering of
securities for the account of the Corporation, provided that the Corporation is
actively employing in good faith its best efforts to cause such registration
statement to become effective and that the Corporation's estimate of the date of
filing such registration statement is made in good faith; (b) the Corporation
shall not be obligated to effect a registration pursuant to this Section 2
within six (6) months after the effective date of a prior registration under
such Section; (c) if the Corporation shall furnish to the Holders a certificate
signed by the President of the Corporation stating that in the good faith
judgment of the Board of Directors it would be seriously detrimental to the
Corporation or its stockholders for a registration statement to be filed in the
near future, then the Corporation's obligation to use its best efforts to file a
registration

                                      -2-
<PAGE>

statement shall be deferred for a period not to exceed three (3) months; and (d)
the Corporation may postpone a registration pursuant to this election for such
period of time as may be required to permit the use of regular audited year-end
financial statements with supplemental short period figures for a period not
exceeding six (6) months unless the Holders agree to bear the costs of any
special audit.

     The Corporation shall not be obligated to effect more than two (2)
registrations pursuant to this Section 2. Any request for registration under
this Section 2 must be for a firm commitment underwritten public offering to be
managed by an underwriter or underwriters of recognized national standing
reasonably acceptable to the Corporation.

     3.  Corporation Registration.  Subject to Section 8 of this Agreement, if
         ------------------------
at any time the Corporation proposes to register any of its Common Stock under
the Act in connection with the public offering of such securities for its own
account or for the accounts of other stockholders, solely for cash on a form
that would also permit the registration of the Registrable Securities, the
Corporation shall, each such time, promptly give each Holder written notice of
such determination.  Upon the written request of any Holder given within thirty
(30) days after mailing of any such notice by the Corporation, the Corporation
shall, subject to the limitations set forth in Section 8(a), use its best
efforts to cause to be registered under the Act all of the Registrable
Securities that each such Holder has requested be registered.

     4.  Obligations of the Corporation.  Whenever required under Section 2, 3,
         ------------------------------
or 11 to use its best efforts to effect the registration of any Registrable
Securities, the Corporation shall, as expeditiously as reasonably possible:

         (a) Prepare and file with the Securities and Exchange Commission
("SEC") a registration statement with respect to such Registrable Securities and
use its best efforts to cause such registration statement to become and remain
effective; provided, however, that in connection with any proposed registration
intended to permit an offering of any securities from time to time (i.e., a so-
called "shelf registration"), the Corporation shall in no event be obligated to
cause any such registration to remain effective for more than one hundred eighty
(180) days.

         (b) Prepare and file with the SEC such amendments and supplements to
such registration statement and the prospectus used in connection with such
registration statement as may be necessary to comply with the provisions of the
Act with respect to the disposition of all securities covered by such
registration statement.

         (c) Furnish to the Holders such numbers of copies of a prospectus,
including a preliminary prospectus, in conformity with the requirements of the
Act, and such other documents as they may reasonably request in order to
facilitate the disposition of Registrable Securities owned by them.

         (d) Use its best efforts to register and qualify the securities
covered by such registration statement under such other securities or Blue Sky
laws of such jurisdictions as shall be reasonably appropriate for the
distribution of the securities covered by the registration statement, provided
that the Corporation shall not be required in connection therewith or as a

                                      -3-
<PAGE>

condition thereto to qualify to do business or to file a general consent to
service of process in any such states or jurisdictions, and further provided
that (anything in this Agreement to the contrary notwithstanding with respect to
the bearing of expenses) if any jurisdiction in which the securities shall be
qualified shall require that expenses incurred in connection with the
qualification of the securities in that jurisdiction be borne by selling
stockholders, then such expenses shall be payable by selling stockholders pro
rata, to the extent required by such jurisdiction.

         (e) Provide a transfer agent for the Common Stock no later than the
effective date of the first registration of any Registrable Securities.

     5.  Furnish Information.  It shall be a condition precedent to the
         -------------------
obligations of the Corporation to take any action pursuant to this Agreement
that the Holders shall furnish to the Corporation such information regarding
them, the Registrable Securities held by them, and the intended method of
disposition of such securities as the Corporation shall reasonably request and
as shall be required in connection with the action to be taken by the
Corporation.

     6.  Expenses of Demand Registration.  All expenses incurred in connection
         -------------------------------
with registrations pursuant to Section 2 (excluding underwriters' discounts and
commissions), including, without limitation, all registration and qualification
fees, printers, and accounting fees, fees and disbursements of counsel for the
Corporation, and the reasonable fees and disbursements of one special counsel
for the selling Holders, shall be borne by the Corporation.

     7.  Corporation Registration Expenses.  All expenses (excluding
         ---------------------------------
underwriters' discounts and commissions) incurred in connection with a
registration pursuant to Section 3, including, without limitation, any
additional registration and qualification fees and any additional fees and
disbursements of counsel to the Corporation that result from the inclusion of
securities held by the Holders in such registration and the reasonable fees and
disbursements of one special counsel for the selling stockholders, shall be
borne by the Corporation; provided, however, that if the registration is of
exclusively a secondary offering, the holders shall bear their proportionate
share of the expenses incurred in connection with any registration (provided all
stockholders registering shares thereunder bear their proportionate share of
expenses), except expenses which the Corporation would have incurred whether or
not the securities held by the Holders were included in such registration
(including, without limitation, the expense of preparing normal audited or
unaudited financial statements).

     8.  Underwriting Requirements.
         -------------------------

         (a) In connection with any offering involving an underwriting of
shares being issued by the Corporation, the Corporation shall not be required
under Section 3 to include any of the Holders' Registrable Securities in such
underwriting unless they accept the terms of the underwriting as agreed upon
between the Corporation and the underwriters selected by it, and then only in
such quantity as will not, in the reasonable opinion of the underwriters,
jeopardize the success of the offering by the Corporation.  If the total amount
of securities that all Holders request to be included in an underwritten
offering exceeds the amount of securities that the underwriters reasonably
believe compatible with the success of the offering, the Corporation

                                      -4-
<PAGE>

shall only be required to include in the offering so many of the securities of
the selling Holders as the underwriters reasonably believe will not jeopardize
the success of the offering (the securities so included to be apportioned pro
rata among the selling Holders according to the total amount of securities owned
by said selling Holders, or in such other proportions as shall mutually be
agreed to by such selling Holders), provided that in the case of an offering
involving shares being issued by the Corporation, no such reduction shall be
made with respect to any securities offered by the Corporation for its own
account, and provided further that no securities of any stockholder who is not a
Holder shall be included in such offering, other than securities of stockholders
who have initiated such registration pursuant to the exercise of contractual
rights to do so, unless all securities which the Holders have requested to be
included are included on a pro rata basis with the securities of any other
stockholders who have a contractual right to include their securities in such
offering.

         (b) With respect to any underwriting of shares to be registered under
Section 2, or an underwriting of shares to be registered under Section 11, if
the Holders of a majority of the then outstanding Registrable Securities have
requested registration thereunder, such Holders shall have the right to
designate the managing underwriter or underwriters, subject to the consent of
the Corporation.  In all other circumstances under such Sections and in
connection with registrations under Section 3, the Corporation shall have the
right to designate the managing underwriter or underwriters, subject to the
consent of the Holders of a majority of the Registrable Securities participating
in the underwriting.  In any such case, such consent shall not be unreasonably
withheld or delayed.

     9.  Delay of Registration.  No Holder shall have any right to take any
         ---------------------
action to restrain, enjoin, or otherwise delay any registration as the result of
any controversy that might arise with respect to the interpretation or
implementation of this Agreement.

    10.  Indemnification.  In the event any Registrable Securities are included
         ---------------
in a registration statement under this Agreement:

         (a) To the extent permitted by law, the Corporation will indemnify and
hold harmless each Holder requesting or joining in a registration, any
underwriter (as defined in the Act) for it, and each person, if any, who
controls such Holder or underwriter within the meaning of the Act, against any
losses, claims, damages or liabilities, joint or several, to which they may
become subject under the Act or otherwise, insofar as such losses, claims,
damages or liabilities (or actions in respect thereof) arise out of or are based
on any untrue or alleged untrue statement of any material fact contained in such
registration statement, including, without limitation, any preliminary
prospectus or final prospectus contained therein or any amendments or
supplements thereto, or arise out of or are based upon the omission or alleged
omission to state therein a material fact required to be stated therein, or
necessary to make the statements therein not misleading or arise out of any
violation by the Corporation of any rule or regulation promulgated under the Act
applicable to the Corporation and relating to action or inaction required of the
Corporation in connection with any such registration; and will reimburse each
such Holder, such underwriter, or controlling person for any legal or other
expenses reasonably incurred by them in connection with investigating or
defending any such loss, claim, damage, liability, or action, provided, however,
that the indemnity agreement contained in this Section 10(a) shall not apply

                                      -5-
<PAGE>

to amounts paid in settlement of any such loss, claim, damage, liability or
action if such settlement is effected without the consent of the Corporation
(which consent shall not be unreasonably withheld or delayed) nor shall the
Corporation be liable in any such case for any such loss, claim, damage,
liability or action to the extent that it arises out of or is based upon an
untrue statement or alleged untrue statement or omission or alleged omission
made in connection with such registration statement, preliminary prospectus,
final prospectus, or amendments or supplements thereto, in reliance upon and in
conformity with written information furnished expressly for use in connection
with such registration by any such Holder, underwriter or controlling person.

         (b) To the extent permitted by law, each Holder requesting or joining
in a registration will indemnify and hold harmless the Corporation, each of its
directors, each of its officers who has signed the registration statement, each
person, if any, who controls the Corporation within the meaning of the Act, and
any underwriter for the Corporation (within the meaning of the Act) against any
losses, claims, damages or liabilities to which the Corporation or any such
director, officer, controlling person or underwriter may become subject, under
the Act or otherwise, insofar as such losses, claims, damages or liabilities (or
actions in respect thereto) arise out of or are based upon any untrue statement
or alleged untrue statement of any material fact contained in such registration
statement, including any preliminary prospectus or final prospectus contained
therein or any amendments or supplements thereto, or arise out of or are based
upon the omission or alleged omission to state therein a material fact required
to be stated therein or necessary to make the statements therein not misleading,
in each case to the extent, but only to the extent, that such untrue statement
or alleged untrue statement or omission or alleged omission was made in such
registration statement, preliminary prospectus or final prospectus, or
amendments or supplements thereto, in reliance upon and in conformity with
written information furnished by such Holder expressly for use in connection
with such registration; and will reimburse the Corporation or any such director,
officer, controlling person or underwriter for any legal or other expenses
reasonably incurred by them in connection with investigating or defending any
such loss, claim, damage, liability or action; provided, however, that the
indemnity agreement contained in this Section 10(b) shall not apply to amounts
paid in settlement of any such loss, claim, damage, liability or action if such
settlement is effected without the consent of such Holder (which consent shall
not be unreasonably withheld) and provided further that no Holder shall have any
liability under this Section 10(b) in excess of the net proceeds actually
received by such Holder in the relevant public offering.

         (c) Promptly after receipt by an indemnified party under this Section
10 of notice of the commencement of any action, such indemnified party will, if
a claim in respect thereof is to be made against any indemnifying party under
this Section 10, notify the indemnifying party in writing of the commencement
thereof and the indemnifying party shall have the right to participate in, and,
to the extent the indemnifying party so desires, jointly with any other
indemnifying party similarly noticed, to assume the defense thereof with counsel
mutually satisfactory to the parties.  The failure to notify an indemnifying
party promptly, of the commencement of any such action, if prejudicial to his
ability to defend such action, shall relieve such indemnifying party of any
liability to the indemnified party under this Section 10, but the omission so to
notify the indemnifying party will not relieve him of any liability that he may
have to any indemnified party otherwise than under this Section 10.

                                      -6-
<PAGE>

     11.  Registrations on Form S-3.
          -------------------------

          (a) If (i) the Corporation shall receive a written request (specifying
that it is being made pursuant to this Section 11) from the Holder or Holders of
at least twenty-five percent (25%) of the then outstanding Registrable
Securities that the Corporation file a registration statement on Form S-3 (or
any successor form to Form S-3 regardless of its designation) for a public
offering of shares of the Registrable Securities the reasonably anticipated
aggregate price to the public of which would exceed Two Million Dollars
($2,000,000), and (ii) the Corporation is a registrant entitled to use Form S-3
to register such shares, then the Corporation shall use its best efforts to
cause such shares to be registered on Form S-3 (or any successor form to Form S-
3).

          (b) All expenses (excluding underwriters' discounts and commissions)
incurred in connection with the first two registrations requested pursuant to
Section 11(a), including, without limitation, all registration, qualification,
printing, and accounting fees, and fees and disbursements of one special counsel
to the selling Holder or Holders and counsel to the Corporation, shall be borne
by the Corporation.  All such expenses for registrations pursuant to Section
11(a) after the first two such registrations shall be borne by the Corporation,
except that the selling Holders shall pay all fees of their legal counsel, if
any, in connection therewith.

          (c) Holders' rights to registration under this Section 11 are in
addition to, and not in lieu of, their rights to registration under Sections 2
and 3 of this Agreement.

     12.  Reports Under Securities Exchange Act of 1934.  With a view to making
          ---------------------------------------------
available to the Holders the benefits of Rule 144 promulgated under the Act and
any other rule or regulation of the SEC that may at any time permit a Holder to
sell securities of the Corporation to the public without registration, the
Corporation agrees to use its best efforts to:

          (a) make and keep public information available, as those terms are
understood and defined in Rule 144, at all times subsequent to ninety (90) days
after the effective date of the first registration statement covering an
underwritten public offering filed by the Corporation;

          (b) file with the SEC in a timely manner all reports and other
documents required of the Corporation under the Act and the Securities Exchange
Act of 1934, as amended (the "1934 Act"); and

          (c) furnish to any Holder forthwith upon request a written statement
by the Corporation that it has complied with the reporting requirements of Rule
144 (at any time after ninety (90) days after the effective date of said first
registration statement filed by the Corporation), and of the Act and the 1934
Act (at any time after it has become subject to such reporting requirements), a
copy of the most recent annual or quarterly report of the Corporation, and such
other reports and documents so filed by the Corporation as may be reasonably
requested in availing any such holder to take advantage of any rule or
regulation of the SEC permitting the selling of any such securities without
registration.

                                      -7-
<PAGE>

     13.  Limitations in Connection with Future Grants of Registration Rights.
          -------------------------------------------------------------------
Without the prior written consent of the Holder or Holders of a majority of the
then outstanding Registrable Securities issued or issuable upon conversion of
the Preferred Stock, the Corporation shall not grant rights to cause the
Corporation to register any of its securities to any person or entity other than
the Additional Investors as contemplated hereunder.

     14.  Transfer of Registration Rights.  The registration rights of any
          -------------------------------
Series B Investor, Series C Investor or Investor (and of any permitted
transferee of any Series B Investor, Series C Investor or Investor or its
permitted transferees) under this Agreement with respect to any shares of
Registrable Securities may be transferred to any Affiliate of such Series B
Investor, Series C Investor or Investor or such permitted transferee, or to any
transferee who acquires (otherwise than in a registered public offering) at
least 20,000 shares of Registrable Securities held or acquired as of the date
hereof by such Series B Investor, Series C Investor or Investor; provided,
however, that the Corporation is given written notice by the Holder at the time
of such transfer stating the name and address of the transferee and identifying
the securities with respect to which the rights under this Agreement are being
assigned.  For such purpose, an "Affiliate" of any Series B Investor, Series C
Investor or Investor (or any such transferee) means any general or limited
partner of such Series B Investor, Series C Investor or Investor (or transferee)
if it is a partnership, or any person or entity that, directly or indirectly,
through one or more intermediaries, controls, or is controlled by, or is under
common control with, such Series B Investor, Series C Investor or Investor or
transferee.  In addition, for purposes of this section, in the case of any
Series B Investor, Series C Investor or Investor that is a limited partnership
for which TVM Techno Venture Management Limited Partnership, TVM Techno Venture
Management III GmbH or any of their respective Affiliates serves as a general
partner, the term "Affiliate" of any such Series B Investor, Series C Investor
or Investor shall include KBL Founder Ventures SCA, KB Lux Venture Capital Fund
- - European Biotechnology and their respective Affiliates and Alpinvest
International B.V. and its Affiliates.

     15.  Mergers, Etc.  The Corporation shall not, directly or indirectly,
          -------------
enter into any merger, consolidation or reorganization in which the Corporation
shall not be the surviving corporation unless the proposed surviving corporation
shall, prior to such merger, consolidation or reorganization, agree in writing
to assume the obligations of the Corporation under this Agreement, and for that
purpose references hereunder to "Registrable Securities" shall be deemed to be
references to the securities which the Holders would be entitled to receive in
exchange for Registrable Securities under any such merger, consolidation or
reorganization; provided, however, that the provisions of this Agreement shall
not apply in the event of any merger, consolidation or reorganization in which
the Corporation is not the surviving corporation if the Holders of Registrable
Securities are entitled to receive in exchange therefor (i) cash, or (ii)
securities of the acquiring corporation which may be immediately sold to the
public without registration under the Act.

     16.  Stand-Off Agreement.  Each Holder, if requested by the Corporation and
          -------------------
the managing underwriter of an offering by the Corporation of Common Stock or
other securities of the Corporation pursuant to a registration statement under
the Act, shall agree not to sell publicly or otherwise transfer or dispose of
any Registrable Securities or other securities of the

                                      -8-
<PAGE>

Corporation held by such Holder for a specified period of time (not to exceed
180 days) following the effective date of such registration statement; provided,
that:

          (a) such agreement shall only apply to the first registration
statement covering Common Stock to be sold on the Corporation's behalf to the
public in an underwritten offering; and

          (b) all holders of five percent (5%) or more of the shares of Common
Stock then outstanding (including shares of Common Stock issuable upon the
conversion of Preferred Stock, or other convertible securities, or upon the
exercise of options, warrants or rights) and all officers and directors of the
Corporation enter into similar agreements.

     17.  Accession.  Any Additional Investors as defined in the Purchase
          ---------
Agreement shall automatically become an Investor hereunder by delivering to the
Corporation a written instrument in the form of Exhibit A hereto, by which such
Additional Investor agrees to be bound by the obligations imposed under this
Agreement, whereupon such Additional Investor shall automatically become a party
to this Agreement and shall thereupon be deemed an "Investor" for all purposes
of this Agreement.

     18.  Notices.  All notices, requests, consents and other communications
          -------
hereunder to any party shall be deemed to be sufficient if contained in a
written instrument delivered in person or duly sent by first class mail postage
prepaid (other than to non-U.S. parties) or by fax or DHL, Federal Express or
other internationally recognized courier service, addressed to such party at the
address set forth below or such other address as may hereafter be designated in
writing by the addressee to the addressor listing all parties:

          (i)  if to the Corporation, to:

               Sequenom, Inc.
               11555 Sorrento Valley Road, Suite C
               San Diego, CA 92121
               Attention:  President
               Fax: (619) 350-0344

               with a copy to:

               John A. Denniston, Esq.
               Brobeck, Phleger & Harrison LLP
               550 West C Street, Suite 1300
               San Diego, California 92101
               Fax: (619) 234-3848

          (ii) if to the Series B Investors, the Series C Investors or the
               Investors (or their respective transferees), to their respective
               last known address or their respective address, if any, appearing
               in the books of the Corporation.

                                      -9-
<PAGE>

     19.  Miscellaneous.
          -------------

          (a) This Agreement states the entire agreement of the parties
concerning the subject matter hereof, and supersedes all prior agreements,
written or oral, between or among them concerning such subject matter.

          (b) This Agreement may be amended, and compliance with any provision
of this Agreement may be omitted or waived, only by the written agreement of the
Corporation and the Holders of at least two-thirds in voting power of the then
outstanding Registrable Securities issued or issuable upon conversion of the
Preferred Stock to be bound thereby.

          (c) This Agreement amends and restates the Prior Registration Rights
Agreement, which upon execution hereof shall be of no further force or effect.

          (d) This Agreement shall be governed by, and construed and enforced in
accordance with, the substantive laws of the State of California, without regard
to its principles of conflicts of laws.

          (e) This Agreement may be executed in any number of counterparts, each
such counterpart shall be deemed to be an original instrument, and all such
counterparts together shall constitute but one agreement.  Any such counterpart
may contain one or more signature pages.

                                    *  *  *

                                     -10-
<PAGE>

     IN WITNESS WHEREOF, the parties have executed this Amended and Restated
Registration Rights Agreement as of the date first written above.

                              SEQUENOM, INC.

                              By:
                                 --------------------------------------
                                 Its President

SERIES B INVESTORS:

                              TVM TECHNO VENTURE
                              ENTERPRISES NO. II
                              LIMITED PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner


                              By:   TVM Management LLC
                                      its General Partner

                              By:
                                 --------------------------------------
                              Its:
                                 --------------------------------------


                              TVM INTERTECH LIMITED PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner

                              By:   TVM Management LLC
                                      its General Partner

                              By:
                                 --------------------------------------
                              Its:
                                 --------------------------------------
<PAGE>

                              TVM ZWEITE BETEILIGUNG-US
                              LIMITED PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner

                              By:   TVM Management LLC
                                      its General Partner

                              By:
                                 --------------------------------------
                              Its:
                                 --------------------------------------


                              TVM EUROTECH LIMITED PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner

                              By:   TVM Management LLC
                                      its General Partner

                              By:
                                 --------------------------------------
                              Its:
                                 --------------------------------------


                              TVM TECHNO VENTURE INVESTORS NO. I LIMITED
                              PARTNERSHIP

                              By:
                                 --------------------------------------
                                 General Partner


                              ***

    [SIGNATURE PAGE TO AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                              ALPINVEST INTERNATIONAL B.V.

                              By:
                                 --------------------------------------
                              Its:
                                 --------------------------------------


                              ***

                              -----------------------------------------
                              Hubert Koster


                              -----------------------------------------
                              Ernst-Gunter Afting


    [SIGNATURE PAGE TO AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                              ***

    [SIGNATURE PAGE TO AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

SERIES C INVESTORS:

                              TVM TECHNO VENTURE
                              ENTERPRISES NO. II
                              LIMITED PARTNERSHIP


                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its general partner


                              By:   TVM Management LLC
                                      its general partner


                              By:
                                 --------------------------------------
                              Its:
                                 --------------------------------------


                              TVM INTERTECH
                              LIMITED PARTNERSHIP


                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its general partner


                              By:   TVM Management LLC
                                      its general partner


                              By:
                                 --------------------------------------
                              Its:
                                 --------------------------------------


                              TVM ZWEITE BETEILIGUNG-US
                              LIMITED PARTNERSHIP


                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its general partner


                              By:   TVM Management LLC
                                      its general partner


                              By:
                                 --------------------------------------
                              Its:
                                 --------------------------------------

    [SIGNATURE PAGE TO AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT]
<PAGE>

                              TVM EUROTECH
                              LIMITED PARTNERSHIP


                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its general partner


                              By:   TVM Management LLC
                                      its general partner


                              By:
                                 --------------------------------------
                              Its:
                                 --------------------------------------


                              TVM TECHNO VENTURE INVESTORS NO. I
                              LIMITED PARTNERSHIP


                              By:
                                 --------------------------------------
                                 General Partner



                              ***

                              ALPINVEST INTERNATIONAL B.V.


                              By:
                                 --------------------------------------
                              Its:
                                 --------------------------------------


                              ***

    [SIGNATURE PAGE TO AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                              ***

                              LOMBARD ODIER & CIE


                              By:
                                 --------------------------------------
                              Its:
                                 --------------------------------------


                              ***

    [SIGNATURE PAGE TO AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                              ***

    [SIGNATURE PAGE TO AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                 SEQUENOM, INC.


                         Registration Rights Agreement


                            Investor Signature Page
                            -----------------------


     By executing this page in the space provided, the undersigned hereby agrees
(i) that it is an "Investor" as defined in the Registration Rights Agreement
dated as of December 21, 1998, by and among Sequenom, Inc. and the parties named
therein, (ii) that it is a party to the Registration Rights Agreement for all
purposes and (iii) that it is bound by all terms and conditions of the
Registration Rights Agreement.

     EXECUTED this 21st day of December, 1998.


                              -----------------------------------------
                              (print name)

                              By:
                                 --------------------------------------

                              Title:
                                    -----------------------------------

[INVESTOR SIGNATURE PAGE TO AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT]
<PAGE>

                                                                       Exhibit A
                                                                       ---------

                                 SEQUENOM, INC.


                         Registration Rights Agreement


                       Additional Investor Signature Page
                       ----------------------------------

     By executing this page in the space provided, the undersigned hereby agrees
(i) that it is an "Additional Investor" as defined in the Series D Convertible
Preferred Stock Purchase Agreement dated as of December 21, 1998 and an
"Investor" as defined in the Registration Rights Agreement dated as of December
21, 1998, each by and among Sequenom, Inc. and the parties named therein, (ii)
that it is a party to the Registration Rights Agreement for all purposes and
(iii) that it is bound by all terms and conditions of the Registration Rights
Agreement.

     EXECUTED this ____ day of ____________, 1999.


                              ------------------------------------------
                              (print name)

                              By:
                                 ---------------------------------------
                              Title:
                                    ------------------------------------
                              Address:
                                      ----------------------------------
                              ------------------------------------------
                              ------------------------------------------


                    [ADDITIONAL INVESTOR SIGNATURE PAGE TO
             AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT]
<PAGE>

                                 EXHIBIT 4.16b

                            Form of Voting Agreement
                            ------------------------


<PAGE>

                     AMENDED AND RESTATED VOTING AGREEMENT

     This Amended and Restated Voting (this "Agreement") is entered into as of
December 21, 1998 by and among Sequenom, Inc., a Delaware corporation (the
"Corporation"); Hubert Koster, Nola E. Masterson and Robert E. Patterson (the
"Founders"); TVM Techno Venture Enterprises No. II Limited Partnership, TVM
Intertech Limited Partnership, TVM Zweite Beteiligung-U.S. Limited Partnership,
TVM Eurotech Limited Partnership, TVM Techno Venture Investors No. 1 Limited
Partnership and *** (the "Original Investors"); the holders (the "Series B
Investors") of shares of the Corporation's Series B Convertible Preferred Stock,
$.001 par value per share (the "Series B Preferred Stock"); the holders (the
"Series C Investors") of shares of the Corporation's Series C Convertible
Preferred Stock, $.001 par value per share (the "Series C Preferred Stock"); and
the purchasers of shares of the Corporation's Series D Convertible Preferred
Stock, $.001 par value per share ("Series D Preferred Stock"), pursuant to the
Series D Convertible Preferred Stock Purchase Agreement (the "Purchase
Agreement") dated as of the date hereof, including any Additional Investors as
defined in the Purchase Agreement (all such purchasers of Series D Preferred
Stock under the Purchase Agreement being referred to as the "Investors," and all
such Founders, Original Investors, Series B Investors, Series C Investors and
Investors being referred to as the "Stockholders").

                                   AGREEMENT
                                   ---------

     In consideration of the mutual covenants herein contained, the parties
hereto agree as follows:

     1.  Board of Directors.  The Stockholders agree to vote all shares of the
         ------------------
Corporation's Common Stock, $.001 par value per share ("Common Stock"), Series A
Convertible Preferred Stock, $.001 par value per share ("Series A Preferred
Stock"), Series B Preferred Stock, Series C Preferred Stock, Series D Preferred
Stock and any other class of voting security of the Corporation (the "Shares")
now or hereafter owned or controlled by them, and otherwise to use their
respective best efforts as stockholders of the Corporation, to set the number of
directors of the Corporation at five and to elect as directors, on the date of
this Agreement and in any subsequent election of directors of the Corporation:

         (a) one person designated by the Founders;

         (b) one person designated by the Original Investors;

         (c) one person designated by either (i) GLS LP Investment III Limited
("GLS") for so long as GLS holds at least 793,650 shares of Series C Preferred
Stock, or (ii) the holders of a majority of the Series C Preferred Stock if GLS
holds less than 793,650 shares of Series C Preferred Stock; and

         (d) two persons who are not employees of the Corporation (the
"Independent Directors"), who have experience in the Corporation's industry and
who are reasonably acceptable to a majority of the other directors.

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

     Any person or entity or group of persons or entities entitled to make a
director designation hereunder (a "Designating Party") shall furnish written
notice to the Corporation at least 30 days prior to any election of directors of
its director-designee or director-designees and the Corporation shall furnish
written notice thereof to the Stockholders at least 10 days prior to any such
election of directors.  In the absence of such notice, the director-designee or
director-designees of such Designating Party then serving and previously
designated shall be reelected if still eligible to serve as provided herein.  In
the event that any Designating Party that is a group of Stockholders cannot
agree upon a director-designee, the identity of the director-designee of such
Designating Party shall be determined by a plurality in voting power of the
outstanding capital stock of the Corporation held by the Stockholders
constituting such Designating Party.

     This Agreement is not intended, and shall not be construed, to confer upon
any person designated hereunder for election to the Board of Directors any right
to serve or to continue to serve in such capacity.  Any Designating Party may,
at any time, determine to remove its then-current director-designee and
designate another person for election to the Board of Directors in place of the
person then serving as the director-designee of such Designating Party.  In the
event any such determination is made, the Stockholders shall promptly vote to
remove the director-designee of such Designating Party then serving, and to
elect as a director the replacement director-designee of such Designating Party.

     At any time a majority of the directors other than the Independent
Directors may determine to remove any Independent Director from the Board of
Directors and designate another person for election to the Board of Directors in
place of the person then serving as such Independent Director.  In the event any
such determination is made, the Stockholders shall promptly vote to remove the
applicable Independent Director and to elect as a director the replacement
Independent Director-designee.

     Any vacancy on the Board of Directors created by the resignation, removal,
incapacity, or death of any person designated under this Section 1 shall be
filled by another person designated by the original Designating Party.  The
Stockholders shall vote their respective Shares in accordance with such new
designation, and any such vacancy shall not be filled in the absence of a new
designation by the original Designating Party.

     This Section 1 shall terminate and be of no further force and effect upon
the closing of a firm commitment underwritten public offering of Common Stock of
the Corporation pursuant to an effective registration statement under the
Securities Act of 1933, as amended, in which the aggregate gross proceeds to the
Corporation from such offering are not less than $20,000,000 and the offering
price per share is not less than $10.00, appropriately adjusted to take account
of any stock split, stock dividend, combination of shares or similar event.

     In the event that any Designating Party (or its or their respective
partners, stockholders and affiliates) owns, in the aggregate, fewer than
200,000 shares of the Corporation's Common Stock, subject to adjustment for
stock splits, stock dividends, combinations of shares and similar events, such
Designating Party's right to make designations under this Section 1 shall
terminate, and the obligation of the other parties under this Section 1 to vote
for any members of the Board of Directors designated by such Designating Party
shall terminate, but all other obligations of all parties hereunder shall
continue unless otherwise terminated.  For purposes of this paragraph, in

                                      -2-
<PAGE>

determining the number of shares of Common Stock owned by a Designating Party,
ownership by such Designating Party of shares of Series A Preferred Stock,
Series B Preferred Stock, Series C Preferred Stock or Series D Preferred Stock
shall be deemed to be ownership by it of that number of shares of Common Stock
into which such shares of Series A Preferred Stock, Series B Preferred Stock,
Series C Preferred Stock and Series D Preferred Stock are convertible.

     2.  Director Indemnification.  In the event that any director contemplated
         ------------------------
by this Agreement shall be made or threatened to be made a party to any action,
suit or proceeding with respect to which he may be entitled to indemnification
by the Corporation pursuant to its Certificate of Incorporation, By-Laws or
otherwise, he shall be entitled to be represented in such action, suit or
proceeding by counsel of his choice and the expenses of such representation
shall be reimbursed by the Corporation to the extent provided in or authorized
by said Certificate of Incorporation or other provision and permitted by
applicable law.

     The Corporation and the Stockholders agree not to take any action to amend
any provision of the Certificate of Incorporation or By-Laws of the Corporation
relating to indemnification of directors, as presently in effect, without the
prior written consent of holders of at least two-thirds in voting power of the
Shares held by Founders, Original Investors, Series B Investors, Series C
Investors and the Investors, voting together as a single class.

     3.  Accession.  Any Additional Investors as defined in the Purchase
         ---------
Agreement shall automatically become an Investor hereunder by delivering to the
Corporation a written instrument in the form of Exhibit A hereto, by which such
                                                ---------
Additional Investor agrees to be bound by the obligations imposed under this
Agreement, whereupon such Additional Investor shall automatically become a party
to this Agreement and shall thereupon be deemed an "Investor" and a
"Stockholder" for all purposes of this Agreement.

     4.  Notices.  All notices, requests, consents and other communications
         -------
hereunder to any party shall be deemed to be sufficient if contained in a
written instrument delivered in person or duly sent by first class mail postage
prepaid (other than to non-U.S. parties), by fax, or by DHL, Federal Express or
any other internationally recognized express courier service, addressed to such
party at the address set forth below or such other address as may hereafter be
designated in writing by the addressee to the addressor listing all parties:

               (i)  if to the Corporation, to:

                    Sequenom, Inc.
                    11555 Sorrento Valley Road, Suite C
                    San Diego, CA 92121
                    Attention:  President
                    Fax: (619) 350-0344

                                      -3-
<PAGE>

               (ii)  with a copy to:

                     John A. Denniston, Esq.
                     Brobeck, Phleger & Harrison LLP
                     550 West C Street, Suite 1300
                     San Diego, CA 92101
                     Fax: (619) 234-3848

             (iii)  if to the Stockholders, to their respective last known
                    address or their respective address, if any, appearing in
                    the books of the Corporation.


     5.  Assignment; Binding Effect.  No Designating Party may assign its or
         --------------------------
their rights hereunder.  Subject to termination or partial termination as
provided in Section 1, this Agreement shall be binding on the parties hereto and
their respective legal representatives, successors and permitted assigns and on
the transferees of any Shares now owned or hereafter acquired by them.

     6.  Entire Agreement; Amendment and Waiver.  This Agreement contains the
         --------------------------------------
sole and entire understanding of the parties with respect to its subject matter
and supersedes all prior negotiations, commitments, agreements and
understandings heretofore had among any of them with respect thereto.  Without
limiting the generality of the foregoing, this Agreement amends and restates the
Voting Agreement among the Corporation, the Founders, the Original Investors,
the Series B Investors and the Series C Investors dated as of May 8, 1997, as
amended as of January 12, 1998, which shall no longer have any force or effect.
This Agreement may not be changed or terminated or any performance or condition
waived, in whole or in part, except by the written agreement of the Corporation
and Stockholders or transferees of their rights hereunder holding at least two-
thirds in voting power of the Shares held by the Founders, two-thirds in voting
power of the Shares held by the Original Investors, two-thirds in voting power
of the Shares held by the Series B Investors, two-thirds in voting power of the
Shares held by the Series C Investors, and two-thirds in voting power of the
Shares held by the Investors.  A waiver on one occasion shall not constitute a
waiver on any further occasion.

     7.  Counterparts.  This Agreement may be executed in more than one
         ------------
counterpart, each of which shall be deemed to be an original and which,
together, shall constitute one and the same instrument.  Any such counterpart
may contain one or more signature pages.

     8.  Applicable Law.  This Agreement shall be governed by, and construed and
         --------------
enforced in accordance with, the substantive laws of the State of California,
without regard to its principles of conflicts of laws.

     9.  Legend.  Each certificate for Shares shall bear a legend stating in
         ------
substance as follows, and each of the Stockholders shall cause its certificates
to be so legended promptly after the execution and delivery of this Agreement:

     The shares of stock represented by this certificate are subject to the
     terms and provisions of a Voting Agreement among the Corporation and
     certain stockholders of the Corporation.  The Corporation will furnish a
     copy of

                                      -4-
<PAGE>

     the Voting Agreement to the holder hereof upon written request and
     without charge.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]


                                     -5-
<PAGE>

     IN WITNESS WHEREOF, the parties have executed this Amended and Restated
Voting Agreement as of the date first written above.

                              SEQUENOM, INC.

                              By:
                                 -------------------------------------
                                 Its President

FOUNDERS:


                              ----------------------------------------
                              Hubert Koster


                              ----------------------------------------
                              Nola E. Masterson


                              ----------------------------------------
                              Robert E. Patterson

ORIGINAL INVESTORS:

                              TVM TECHNO VENTURE
                              ENTERPRISES NO. II
                              LIMITED PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner

                              By:   TVM Management LLC
                                      its General Partner

                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------
<PAGE>

                              TVM INTERTECH LIMITED
                              PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner

                              By:   TVM Management LLC
                                      its General Partner

                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


                              TVM ZWEITE BETEILIGUNG-US
                              LIMITED PARTNERSHIP


                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner

                              By:   TVM Management LLC
                                      its General Partner

                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


                              TVM EUROTECH LIMITED PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner

                              By:   TVM Management LLC
                                      its General Partner

                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------

           [SIGNATURE PAGE TO AMENDED AND RESTATED VOTING AGREEMENT]
<PAGE>

                              TVM TECHNO VENTURE INVESTORS NO. I LIMITED
                              PARTNERSHIP

                              By:
                                 -------------------------------------
                                 General Partner



                              KBL FOUNDER VENTURES SCA

                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------

SERIES B INVESTORS:

                              TVM TECHNO VENTURE
                              ENTERPRISES NO. II
                              LIMITED PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner

                              By:   TVM Management LLC
                                      its General Partner

                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


                              TVM INTERTECH LIMITED PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner

                              By:   TVM Management LLC
                                      its General Partner

                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------

           [SIGNATURE PAGE TO AMENDED AND RESTATED VOTING AGREEMENT]
<PAGE>

                              TVM ZWEITE BETEILIGUNG-US
                              LIMITED PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner

                              By:   TVM Management LLC
                                      its General Partner

                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


                              TVM EUROTECH LIMITED PARTNERSHIP


                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner

                              By:   TVM Management LLC
                                      its General Partner

                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


                              TVM TECHNO VENTURE INVESTORS NO. I LIMITED
                              PARTNERSHIP

                              By:
                                 -------------------------------------
                                 General Partner



                              ***

           [SIGNATURE PAGE TO AMENDED AND RESTATED VOTING AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                              ALPINVEST INTERNATIONAL B.V.

                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


                              ***


                              ----------------------------------------
                              Hubert Koster


                              ----------------------------------------
                              Ernst-Gunter Afting

           [SIGNATURE PAGE TO AMENDED AND RESTATED VOTING AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                              ***

           [SIGNATURE PAGE TO AMENDED AND RESTATED VOTING AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

SERIES C INVESTORS:

                              TVM TECHNO VENTURE
                              ENTERPRISES NO. II
                              LIMITED PARTNERSHIP


                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its general partner


                              By:   TVM Management LLC
                                      its general partner


                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


                              TVM INTERTECH
                              LIMITED PARTNERSHIP


                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its general partner


                              By:   TVM Management LLC
                                      its general partner


                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


                              TVM ZWEITE BETEILIGUNG-US
                              LIMITED PARTNERSHIP


                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its general partner


                              By:   TVM Management LLC
                                      its general partner


                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------

           [SIGNATURE PAGE TO AMENDED AND RESTATED VOTING AGREEMENT]
<PAGE>

                              TVM EUROTECH
                              LIMITED PARTNERSHIP


                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its general partner


                              By:   TVM Management LLC
                                      its general partner



                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


                              TVM TECHNO VENTURE INVESTORS NO. I LIMITED
                              PARTNERSHIP


                              By:
                                 -------------------------------------
                                 General Partner



                              ***

                              ALPINVEST INTERNATIONAL B.V.


                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


                              ***

           [SIGNATURE PAGE TO AMENDED AND RESTATED VOTING AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                              ***

                              LOMBARD ODIER & CIE


                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


                              ***

           [SIGNATURE PAGE TO AMENDED AND RESTATED VOTING AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                              ***

           [SIGNATURE PAGE TO AMENDED AND RESTATED VOTING AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                 SEQUENOM, INC.
                                Voting Agreement

                            Investor Signature Page
                            -----------------------

     By executing this page in the space provided, the undersigned hereby agrees
(i) that it is an "Investor" and a "Stockholder" as defined in the Voting
Agreement dated as of December 21, 1998, by and among Sequenom, Inc. and the
parties named therein, (ii) that it is a party to the Voting Agreement for all
purposes and (iii) that it is bound by all terms and conditions of the Voting
Agreement.

     EXECUTED this 21st day of December, 1998.


                              ------------------------------------------
                              (Print name)

                              By:
                                 ---------------------------------------
                              Title:
                                    ------------------------------------
                              Address:
                                      ----------------------------------

      [INVESTOR SIGNATURE PAGE TO AMENDED AND RESTATED VOTING AGREEMENT]
<PAGE>

                                                                       Exhibit A
                                                                       ---------

                                 SEQUENOM, INC.
                                Voting Agreement

                       Additional Investor Signature Page
                       ----------------------------------

     By executing this page in the space provided, the undersigned hereby agrees
(i) that it is an "Additional Investor" as defined in the Series D Convertible
Preferred Stock Purchase Agreement dated as of December 21, 1998, and an
"Investor" and a "Stockholder" as defined in the Voting Agreement dated as of
December 21, 1998, each by and among Sequenom, Inc. and the parties named
therein, (ii) that it is a party to the Voting Agreement for all purposes and
(iii) that it is bound by all terms and conditions of the Voting Agreement

     EXECUTED this ____ day of _________________, 1999.


                              ------------------------------------------
                              (Print name)

                              By:
                                 ---------------------------------------
                              Title:
                                    ------------------------------------
                              Address:
                                      ----------------------------------


 [ADDITIONAL INVESTOR SIGNATURE PAGE TO AMENDED AND RESTATED VOTING AGREEMENT]
<PAGE>

                                 EXHIBIT 4.16C

                      Form of Stock Restriction Agreement
                      -----------------------------------
<PAGE>

                AMENDED AND RESTATED STOCK RESTRICTION AGREEMENT

     This Amended and Restated Stock Restriction Agreement (this "Agreement") is
entered into as of December 21, 1998 by and among Sequenom, Inc., a Delaware
corporation (the "Corporation"); Hubert Koster ("Koster"), Nola E. Masterson
("Masterson") and Robert E. Patterson ("Patterson," and together with Koster and
Masterson, the "Founders"); the holders (the "Series B Investors") of shares of
the Corporation's Series B Convertible Preferred Stock, $.001 par value per
share (the "Series B Preferred Stock"); the holders (the "Series C Investors")
of shares of the Corporation's Series C Convertible Preferred Stock, $.001 par
value per share (the "Series C Preferred Stock"); and the purchasers of shares
of the Corporation's Series D Convertible Preferred Stock, par value $.001 per
share ("Series D Preferred Stock"), pursuant to the Series D Convertible
Preferred Stock Purchase Agreement dated as of the date hereof (the "Purchase
Agreement"), including any Additional Investors as defined in the Purchase
Agreement (such purchasers being hereinafter referred to as the "Series D
Investors", and, together with the Series B Investors and the Series C
Investors, the "Investors").

                         W I T N E S S E T H   T H A T

     WHEREAS, the Series D Investors wish to purchase from the Corporation
certain shares of Series D Preferred Stock;

     WHEREAS, the Series D Investors' purchase of such Series D Preferred Stock
would materially benefit the Founders, the Series B Investors and the Series C
Investors as holders of certain shares of the Corporation's capital stock and
rights to acquire such capital stock;

     WHEREAS, it is a condition to the obligations of the Series D Investors
under the Purchase Agreement that this Agreement be executed by the Corporation,
the Founders, the Series B Investors and the Series C Investors, and the
Corporation, the Founders, the Series B Investors and the Series C Investors are
willing to execute this Agreement and to be bound by the provisions hereof;

     NOW, THEREFORE, in consideration of the foregoing, the agreements set forth
below, and the parties' desire to provide for continuity of ownership of the
Corporation to further the interests of the Corporation and its present and
future stockholders, the parties hereby agree with each other as follows:

     1.  Certain Defined Terms.  As used in this Agreement, the following terms
         ---------------------
shall have the following respective meanings:

         (a) "Common Stock" means the Corporation's Common Stock, $.001 par
value per share.

         (b) "Convertible Securities" means any evidences of indebtedness,
shares of capital stock or other securities directly or indirectly convertible
into or exchangeable for Common Stock.
<PAGE>

         (c) "Options" means any rights, options, or warrants to subscribe for,
purchase or otherwise acquire Common Stock or Convertible Securities.

         (d) "Series A Preferred Stock" means the Corporation's Series A
Convertible Preferred Stock, $.001 par value per share.

         (e) "Shares" shall mean and include all shares of Stock now owned or
hereafter acquired by any Founder or any Investor.

         (f) "Stock" shall mean and include all shares of Common Stock, all
Convertible Securities, all Options, and all other securities of the Corporation
which may be issued in exchange for or in respect of shares of Common Stock,
Convertible Securities or Options (whether by way of stock split, stock
dividend, combination of shares, reclassification, recapitalization,
reorganization, or any other means).

     2.  Prohibited Transfers.  None of the Investors or Founders shall sell or
         --------------------
otherwise transfer, by gift or otherwise, all or any part of his Shares except
in compliance with the terms of this Agreement.

     3.  Offer of Sale; Notice of Proposed Sale or Transfer.  If any Founder
         --------------------------------------------------
desires to sell or otherwise transfer any of his Shares, or of any interest
therein, whether voluntarily or by operation of law, in any transaction other
than pursuant to clauses (iii) or (iv) of Section 7(a) of this Agreement, such
Founder (the "Selling Founder") shall first deliver written notice of his desire
to do so (the "Selling Founder's Notice") to the Corporation and each of the
other Investors.  If any Investor desires to sell or otherwise transfer an
aggregate of 50,000 or more Shares in one transaction or multiple transactions,
or of any interest therein, whether voluntarily or by operation of law, other
than in connection with any transaction described in Section 8(c) of this
Agreement, such Investor (the "Selling Investor") shall first deliver written
notice of his desire to do so (the "Selling Investor's Notice") to the
Corporation.  The Selling Founder's Notice and the Selling Investor's Notice
must specify:  (i) the name and address of the party to which the Selling
Investor or Selling Founder proposes to sell or otherwise transfer the Shares or
an interest in the Shares (the "Proposed Transferee"), (ii) the number of Shares
the Selling Investor or Selling Founder proposes to sell or otherwise transfer
(the "Offered Shares"), (iii) the consideration per Share to be delivered to the
Selling Investor or Selling Founder for the proposed sale or transfer, and (iv)
all other material terms and conditions of the proposed transaction, which must
be bona fide.

     4.  Corporation's Option to Purchase Shares of Selling Founder.
         ----------------------------------------------------------

         (a) Except as set forth in Section 7(a), the Corporation shall have
the first option to purchase all or any part of the Offered Shares for the
consideration per Share and on the terms and conditions specified in the Selling
Founder's Notice.  The Corporation must exercise such option, no later than
fifteen (15) business days after such Selling Founder's Notice is deemed to have
been delivered to it, by written notice to the Selling Founder.

         (b) In the event the Corporation does not exercise its option within
such fifteen-business-day period with respect to all of the Offered Shares, the
Chief Financial Officer

                                      -2-
<PAGE>

of the Corporation shall, by the last day of such period, give written notice of
that fact to the Investors (the "Investor Notice"). The Investor Notice shall
specify the number of Offered Shares the Corporation has elected not to purchase
(the "Remaining Shares").

         (c) In the event the Corporation duly exercises its option to purchase
all or a portion of the Offered Shares, the closing of such purchase shall take
place at the offices of the Corporation on the later of (i) the date five
business days after the expiration of such fifteen-business-day period or (ii)
the date that the Investors consummate their purchase of Offered Shares under
Section 5(c) hereof.

         (d) To the extent that the consideration proposed to be paid by the
Proposed Transferee for the Offered Shares consists of property other than cash
or a promissory note, the consideration required to be paid by the Corporation
and/or the Investors exercising their options under Sections 4 and 5 hereof,
respectively, may consist of cash equal to the value of such property, as
determined in good faith by agreement of the Selling Founder and the Corporation
and/or the Investors acquiring such Offered Shares.

     5.  Investors' Option to Purchase and Right to Participate in Sales by
         ------------------------------------------------------------------
Founders.
- --------

         (a) Except as set forth in Section 7(a), each Investor shall have an
option, exercisable for a period of fifteen (15) business days from the date of
delivery of the Investor Notice, to purchase, on a pro rata basis, its
Proportionate Percentage (as defined below) of the Remaining Shares, for the
consideration per Share and on the terms and conditions set forth in the Selling
Founder's Notice.  Such option shall be exercised by delivery of written notice
to the Chief Financial Officer of the Corporation.  Alternatively, each Investor
may, within the same fifteen-business-day period, notify the Chief Financial
Officer of the Corporation of its desire to participate in the sale of Shares
and to sell, on the terms as set forth in the Selling Founder's Notice including
at the same price per Share on a common equivalent basis, up to an equivalent
proportion of the Series B Preferred Stock, Series C Preferred Stock and Series
D Preferred Stock owned by such Investor as the proposed sale of the Remaining
Shares represents with respect to the Shares then owned by the Selling Founder.

         (b) In the event options to purchase have been exercised by the
Investors with respect to some but not all of the Remaining Shares, the Chief
Financial Officer of the Corporation shall promptly give written notice of that
fact to those Investors who have exercised their options within such period (the
"Second Investor Notice").  The Second Investor Notice shall specify the number
of Remaining Shares the Investors have not elected to purchase (the "Additional
Remaining Shares").  The Investors who have exercised their options within the
fifteen-business-day period specified in Section 5(a) shall have an additional
option, for a period of ten (10) business days after delivery of the Second
Investor Notice, to purchase all or any part of the Additional Remaining Shares
on the terms and conditions set forth in the Selling Founder's Notice, which
option shall be exercised by the delivery of written notice to the Chief
Financial Officer of the Corporation.  In the event that there are two or more
such Investors that choose to exercise the last-mentioned option for a total
number of Additional Remaining Shares in excess of the number available, the
Additional Remaining Shares available for each such Investor's option shall be
allocated to such Investors pro rata based on that percentage calculated by
dividing (i) the number of Remaining Shares each such Investor elected to
purchase in

                                      -3-
<PAGE>

response to the Investor Notice by (ii) the aggregate number of Remaining Shares
elected to be purchased (in response to the Investor Notice) by all such
Investors, and only those Investors, electing to purchase any portion of the
Additional Remaining Shares (in response to the Second Investor Notice),
provided, however, that if the number of Additional Remaining Shares so
calculated for any such Investor exceeds the number of the Additional Remaining
Shares such Investor has elected to purchase, then that Investor shall receive
the number of Additional Remaining Shares such Investor has elected to purchase,
and the excess Additional Remaining Shares shall be reallocated on an equitable
basis (as determined by the Board of Directors of the Corporation) among the
remaining Investors electing to purchase any of the Additional Remaining Shares.

         (c) Promptly after the expiration of the last period for exercise of
an Investor's purchase option, the Chief Financial Officer of the Corporation
shall give written notice to the Selling Founder and the purchasing Investors,
specifying the number of Remaining Shares to be purchased by each purchasing
Investor.  The closing of the purchase of the Remaining Shares shall take place
at the offices of the Corporation no later than five (5) business days after
delivery of such notice to the Selling Founder and the purchasing Investors.

         (d) As used in this Section 5, the term "Proportionate Percentage"
shall mean with respect to each Investor a fraction, the numerator of which
shall be the amount of Series B Preferred Stock, Series C Preferred Stock and
Series D Preferred Stock owned by such Investor, and the denominator of which
shall be the total amount of Series B Preferred Stock, Series C Preferred Stock
and Series D Preferred Stock owned by all Investors, in each case on a common
equivalent basis.

     6.  Co-Sale.
         -------

         (a) If the Corporation and the Investors do not exercise their options
to purchase all of the Offered Shares within the periods described in this
Agreement (the "Option Period"), then each Investor which has, pursuant to
Section 5(a), expressed a desire to sell shares of Series B Preferred Stock,
Series C Preferred Stock and Series D Preferred Stock in the transaction (a
"Participating Investor") shall be entitled to do so pursuant to this Section.
The Chief Financial Officer of the Corporation shall promptly, on expiration of
the Option Period, notify the Selling Founder of the aggregate amount of Series
B Preferred Stock, Series C Preferred Stock and Series D Preferred Stock the
Participating Investors wish to sell.  The Selling Founder shall use his best
efforts to interest the Proposed Transferee in purchasing, in addition to the
Remaining Shares not subscribed for by the Investors, the Series B Preferred
Stock, Series C Preferred Stock and Series D Preferred Stock the Participating
Investors wish to sell.  If the Proposed Transferee does not wish to purchase
all of the Stock so made available by the Selling Founder and the Participating
Investors, then each Participating Investor and the Selling Founder shall be
entitled to sell, on the terms and conditions set forth in the Selling Founder's
Notice and on the same price per share on a common equivalent basis, a portion
of the Stock being sold to the Proposed Transferee, in the same proportion as
such Selling Founder or Participating Investor's ownership of Stock on a common
equivalent basis bears to the aggregate amount of Stock owned by the Selling
Founder and the Participating Investors on a common equivalent basis.  The
transaction contemplated by the Selling Founder's Notice shall be consummated
not later than 60 days after the expiration of the Option Period.

                                      -4-
<PAGE>

         (b) If the Participating Investors do not elect to sell the full
amount of Series B Preferred Stock, Series C Preferred Stock and Series D
Preferred Stock which they are entitled to sell pursuant to Section 6(a), the
Selling Founder shall be entitled to sell to the Proposed Transferee, according
to the terms set forth in the Selling Founder's Notice, that number of his
Shares which equals the difference between the amount of Stock desired to be
purchased by the Proposed Transferee and the number of shares of Series B
Preferred Stock, Series C Preferred Stock and Series D Preferred Stock the
Participating Investors wish to sell, in each case on a common equivalent basis.

         (c) If the Selling Founder wishes to sell or otherwise transfer any of
his Shares at a price per Share which differs from that set forth in the Selling
Founder's Notice, upon terms different from those previously offered to the
Corporation and the Investors, or more than 60 days after the expiration of the
Option Period, then, as a condition precedent to such transaction, such Shares
must first be offered to the Corporation and the Investors on the same terms and
conditions as given the Proposed Transferee, and the Investors must first be
offered the opportunity to participate in such transaction, in accordance with
the procedures and time periods set forth above.

     7.  Permitted Transfers.
         -------------------

         (a) Subject to the provisions of Section 7(b) and Section 8, the
Corporation's and the Investors' right of first refusal and the Investors' right
of co-sale described in Sections 4 through 6 shall not apply to:  (i) any
transfer of Shares by a Founder by gift or bequest or through inheritance to, or
for the benefit of, any member or members of such Founder's immediate family;
(ii) any transfer of Shares by a Founder to a trust (A) in respect of which such
Founder serves as trustee, provided that the trust instrument governing such
trust shall provide that such Founder, as trustee, shall retain sole and
exclusive control over the voting and disposition of such Shares until the
termination of this Agreement or (B) for the benefit solely of any member or
members of such Founder's immediate family; (iii) any sale or transfer of Shares
to the Corporation; (iv) any underwritten public offering of Common Stock
pursuant to an effective registration statement under the Securities Act of
1933, as amended (the "Securities Act"); and (v) with respect to sales or other
transfers of up to an aggregate of the following number of Shares (as adjusted
to reflect any stock split, stock dividend, combination of shares or other
similar transaction), but subject in any case to the restrictions set forth in
Section 8:  (A) in the case of each of Koster and Masterson, 130,000 Shares; and
(B) in the case of Patterson, 50,000 Shares;

         (b) In the event of any sale or transfer described in clauses (i) or
(ii) of Section 7(a), the transferee of the Shares shall hold the Shares so
acquired subject to all the restrictions imposed by this Agreement and shall be
deemed a Founder for all purposes hereof, and as a condition to such transfer,
any such transferee shall, at the request of the Corporation or any Investor,
execute and deliver a written instrument agreeing to be bound by the provisions
of this Agreement.

                                      -5-
<PAGE>

     8.  Consent of the Corporation to Transfer.
         --------------------------------------

         (a) As a condition to selling or otherwise transferring any Shares
proposed to be sold or transferred by a Selling Founder and any Participating
Investor to any Proposed Transferee, other than a sale or transfer described in
clause (iii) or (iv) of Section 7(a), the Selling Founder or Participating
Investor shall have obtained the written consent to such transfer by the Board
of Directors of the Corporation by majority vote at a meeting or by unanimous
consent in lieu of a meeting.  Such consent shall not be unreasonably withheld,
and shall be based on the Board of Directors' determination, after such inquiry
as it deems appropriate, but within thirty days of the date of the Selling
Founder's Notice to the Corporation under Section 3, that the Proposed
Transferee is not a competitor of the Corporation and is not otherwise an
inappropriate investor in the Corporation.  In the event the Selling Founder
disagrees with such determination, and the Board of Directors and the Selling
Founder are unable to resolve the disagreement, an independent third party
selected and agreed upon by the Board of Directors and the Selling Founder shall
arbitrate and finally resolve the disagreement.

         (b) As a condition to selling or otherwise transferring 50,000 or more
Shares proposed to be sold or transferred by a Selling Investor to any Proposed
Transferee, the Selling Investor shall have obtained the consent, by majority
vote at a meeting or by unanimous written consent in lieu of a meeting, of the
Board of Directors of the Corporation.  Such consent shall not be unreasonably
withheld, and shall be based on the Board of Directors' determination, after
such inquiry as it deems appropriate, but within ten (10) business days of the
date of the Selling Investor' s Notice to the Corporation under Section 3, that
the Proposed Transferee is not a competitor of the Corporation.  In the event
the Selling Investor disagrees with such determination, and the Board of
Directors and the Selling Investor are unable to resolve the disagreement, an
independent third party selected and agreed upon by the Board of Directors and
the Selling Investor shall arbitrate and finally resolve the disagreement.

         (c) Notwithstanding the foregoing, Section 8(b) shall not apply to any
Investor's sale or transfer of Shares to any Affiliate of such Investor.  For
such purpose, an "Affiliate" of any Investor means any general or limited
partner of such Investor if it is a partnership, or any person that, directly or
indirectly, through one or more intermediaries, controls, or is controlled by,
or is under common control with, such Investor.  In addition, for such purpose,
in the case of any Investor that is a limited partnership for which TVM Techno
Venture Management Limited Partnership, TVM Techno Venture Management III GmbH
or any of their respective Affiliates serves as general partner, the term
"Affiliate" shall include KBL Founder Ventures SCA, KB Lux Venture Capital Fund-
- -European Biotechnology and their respective Affiliates and Alpinvest
International B.V. and its Affiliates.

     9.  Corporation's Option to Purchase Shares of Selling Investor.
         -----------------------------------------------------------

         (a) If the Board of Directors determines that the Proposed Transferee
of a Selling Investor is a competitor of the Corporation, the Corporation shall
have the option to purchase all, but not less than all, of the Offered Shares
for the consideration per Share and on the terms and conditions specified in the
Selling Investor's Notice.  The Corporation must exercise such option, no later
than ten (10) business days after such Selling Investor's Notice is deemed to
have been delivered to it, by written notice to the Selling Investor.

                                      -6-
<PAGE>

         (b) In the event the Corporation does not exercise its option within
such ten-business-day period with respect to all of the Offered Shares, the
Selling Investor shall be entitled to sell to the Proposed Transferee, according
to the terms set forth in the Selling Investor's Notice, the Offered Shares.

         (c) In the event the Corporation duly exercises its option to purchase
all of the Offered Shares, the closing of such purchase shall take place at the
offices of the Corporation no later than ten (10) business days after the notice
by the Corporation to exercise its option is deemed to have been delivered to
the Selling Investor.

         (d) To the extent that the consideration proposed to be paid by the
Proposed Transferee for the Offered Shares consists of property other than cash
or a promissory note, the consideration required to be paid by the Corporation
exercising its option under this Section 9, may consist of cash equal to the
value of such property, as determined in good faith by agreement of the Selling
Investor and the Corporation.

     10.  Lock-up.  Each Founder agrees that upon the request of the Corporation
          -------
or the underwriters managing an underwritten offering of the Corporation's
securities, such Founder will not sell, make any short sale or loan of, grant
any option for the purchase of, or otherwise dispose of any Shares held by him
without the prior written consent of the Corporation or such underwriters, as
the case may be, for a period of up to 180 days from effective date of the
applicable registration statement.

     11.  Sale or Transfer in Violation of this Agreement.  If any sale or other
          -----------------------------------------------
transfer of Shares is made or attempted in violation of any provision of this
Agreement, or if any Shares are not offered to the Corporation or the Investors
as required hereby, the Corporation and the Investors, as the case may be, shall
have the right to purchase such Shares from the owner thereof or his transferee
at any time before or after the transfer, as herein provided.  In addition to
any other legal or equitable remedies which it or they may have, the Corporation
and the Investors may enforce their respective rights hereunder by actions for
specific performance (to the extent permitted by law).  The Corporation shall
not be required (i) to transfer on its books any Shares or other Stock which has
been sold or transferred in violation of any provision of this Agreement or (ii)
to treat as the owner of such Shares or Stock, or to pay dividends to, any
transferee to whom any such Shares or Stock have been so sold or transferred.
If a Founder becomes obligated to sell any Shares to the Corporation under this
Agreement and fails to deliver such Shares in accordance with the terms of this
Agreement, the Corporation may, at its option, in addition to all other remedies
it may have, send to such Founder the purchase price for such Shares as is
herein specified and cancel on its books the certificate or certificates
representing the Shares to be sold. Thereafter, all of the Founder's rights in
and to such Shares shall terminate.

     12.  Disposition of Shares.  Any Shares that the Corporation elects to
          ---------------------
purchase hereunder may be disposed of by it in such manner as it deems
appropriate with or without restrictions on the transfer thereof, and the
Corporation may require their transfer to a nominee or designee as part of any
purchase of the Shares from the Founders.

     13.  Restrictive Legend.  All certificates representing Shares held by the
          ------------------
Founders or Investors which are subject to this Agreement shall have affixed
thereto a legend in substantially

                                      -7-
<PAGE>

the following form, in addition to any other legends that may be required by the
Corporation in connection with compliance with federal or state securities laws
or otherwise:

"The shares of stock represented by this certificate are subject to restrictions
on transfer and/or an option to purchase set forth in a Stock Restriction
Agreement between the Corporation and the registered owner of the shares
represented by this certificate (or his predecessor in interest).  The
Corporation will furnish a copy of such agreement to the holder of this
certificate upon written request without charge."

The Founders and Investors shall cause such legend to be affixed to any of such
certificates not so legended.

     14.  Term.  This Agreement shall terminate upon the closing of a firm
          ----
commitment underwritten public offering of Common Stock pursuant to an effective
registration statement under the Securities Act in which (i) the public offering
price per share is not less than $10.00 (appropriately  adjusted to take account
of any stock split, stock dividend, combination of shares or similar event) and
(ii) the aggregate gross proceeds to the Corporation are not less than
$20,000,000.

     15.  Specific Enforcement.  Each Investor and Founder expressly agrees that
          --------------------
a violation of this Agreement by such Investor or Founder could not be
adequately compensated by money damages alone and that the Investors and the
Corporation will be irreparably damaged if this Agreement is not specifically
enforced.  Upon a breach or threatened breach of the terms, covenants and/or
conditions of this Agreement by any Investor or Founder, the other Investors and
the Corporation shall, in addition to all other remedies, each be entitled to a
temporary or permanent injunction, and/or a decree for specific performance, in
accordance with the provisions hereof.

     16.  Other Agreements.  The restrictions on the Founders' right to dispose
          ----------------
of their Shares pursuant to this Agreement are in addition to and to be
construed consistently with the Founders' rights and obligations (including
restrictions on the Founders' right to dispose of shares of the Corporation's
capital stock) contained in any other agreement relating to restrictions on the
transferability of such Shares that the Founders execute before, on, or after
the date hereof; provided, that this Agreement shall amend and restate the Stock
Restriction Agreement dated as of May 8, 1997, as amended as of January 12,
1998, among the Corporation, the Founders, the Series B Investors and the Series
C Investors, which shall no longer be of any force or effect.

     17.  Waiver, Modification and Termination.  No provision of this Agreement
          ------------------------------------
shall be deemed to have been waived by the Corporation or any Investor in the
absence of a written agreement executed by such party with respect to such
waiver.  This Agreement may be modified or terminated only with the written
consent of the Founders, the Corporation, and the holders of two-thirds in
voting power of the Shares then held by the Investors.

     18.  Accession.  Any Additional Investors as defined in the Purchase
          ---------
Agreement shall automatically become an Investor hereunder by delivering to the
Corporation a written instrument in the form of Exhibit A hereto, by which such
                                                ---------
Additional Investor agrees to be bound by the obligations imposed under this
Agreement, whereupon such Additional Investor

                                      -8-
<PAGE>

shall automatically become a party to this Agreement and shall thereupon be
deemed an "Investor" for all purposes of this Agreement.

     19.  Binding Effect; Assignment.  This Agreement shall be binding upon the
          --------------------------
parties hereto and their heirs, legal representatives, successors and assigns.
The rights and obligations of the Founders and Investors hereunder may not be
assigned or delegated without the written consent of the Corporation.

     20.  Notices.  All notices, requests, consents, deliveries and other
          -------
communications hereunder shall be in writing and shall be delivered in person or
duly sent by first class mail postage prepaid (other than in the case of non-
U.S. parties) or by fax or DHL, Federal Express or other internationally
recognized express courier service, to the Corporation at its principal place of
business, and to the Investors and the Founders at their respective last known
address or at their respective address, if any, appearing on the books of the
Corporation.

     21.  Severability.  If any provision of this Agreement shall be held to be
          ------------
illegal, invalid or unenforceable, such illegality, invalidity or
unenforceability shall attach only to such provision and shall not in any manner
affect or render illegal, invalid or unenforceable any other provision of this
Agreement, and this Agreement shall be carried out as if any such illegal,
invalid or unenforceable provision were not contained herein.

     22.  Governing Law.  This Agreement shall be governed by, and construed and
          -------------
enforced in accordance with, the substantive law of the State of California,
without regard to its principles of conflicts of laws.

     23.  Captions.  Captions are for convenience only and are not deemed to be
          --------
part of this Agreement.

     24  Counterparts.  This Agreement may be executed in one or more
         ------------
counterparts, each of which shall be deemed an original and all of which
together shall constitute a single instrument.  Each such counterpart may
contain one or more signature pages.


                                    *  *  *

                                      -9-
<PAGE>

     IN WITNESS WHEREOF, the parties hereto have executed this Amended and
Restated Stock Restriction Agreement as of the day and year first above written.

                              SEQUENOM, INC.

                              By:
                                 -------------------------------------
                                 Its President

FOUNDERS:


                              ----------------------------------------
                              Hubert Koster


                              ----------------------------------------
                              Nola E. Masterson


                              ----------------------------------------
                              Robert E. Patterson

SERIES B INVESTORS:

                              TVM TECHNO VENTURE
                              ENTERPRISES NO. II
                              LIMITED PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner

                              By:   TVM Management LLC
                                      its General Partner

                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------
<PAGE>

                              TVM INTERTECH LIMITED PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner

                              By:   TVM Management LLC
                                      its General Partner

                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


                              TVM ZWEITE BETEILIGUNG-US
                              LIMITED PARTNERSHIP

                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner

                              By:   TVM Management LLC
                                      its General Partner

                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


                              TVM EUROTECH LIMITED PARTNERSHIP


                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its General Partner

                              By:   TVM Management LLC
                                      its General Partner

                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------

     [SIGNATURE PAGE TO AMENDED AND RESTATED STOCK RESTRICTION AGREEMENT]
<PAGE>

                              TVM TECHNO VENTURE INVESTORS NO. I LIMITED
                              PARTNERSHIP

                              By:
                                 -------------------------------------
                                 General Partner


                              ***

                              ALPINVEST INTERNATIONAL B.V.

                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


                              ***

     [SIGNATURE PAGE TO AMENDED AND RESTATED STOCK RESTRICTION AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                              ***

                              ----------------------------------------
                              Hubert Koster


                              ----------------------------------------
                              Ernst-Gunter Afting



                              ***

     [SIGNATURE PAGE TO AMENDED AND RESTATED STOCK RESTRICTION AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                              ***
SERIES C INVESTORS:

                              TVM TECHNO VENTURE
                              ENTERPRISES NO. II
                              LIMITED PARTNERSHIP


                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its general partner


                              By:   TVM Management LLC
                                      its general partner


                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


                              TVM INTERTECH
                              LIMITED PARTNERSHIP


                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its general partner


                              By:   TVM Management LLC
                                      its general partner


                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


     [SIGNATURE PAGE TO AMENDED AND RESTATED STOCK RESTRICTION AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                              TVM ZWEITE BETEILIGUNG-US
                              LIMITED PARTNERSHIP


                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its general partner


                              By:   TVM Management LLC
                                      its general partner


                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


                              TVM EUROTECH
                              LIMITED PARTNERSHIP


                              By:   TVM Techno Venture Management
                                    Limited Partnership
                                      its general partner


                              By:   TVM Management LLC
                                      its general partner


                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


                              TVM TECHNO VENTURE INVESTORS NO. I
                              LIMITED PARTNERSHIP


                              By:
                                 -------------------------------------
                                 General Partner


                              ***

     [SIGNATURE PAGE TO AMENDED AND RESTATED STOCK RESTRICTION AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                              ALPINVEST INTERNATIONAL B.V.


                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


                              ***


                              LOMBARD ODIER & CIE


                              By:
                                 -------------------------------------
                              Its:
                                 -------------------------------------


     [SIGNATURE PAGE TO AMENDED AND RESTATED STOCK RESTRICTION AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                              ***
     [SIGNATURE PAGE TO AMENDED AND RESTATED STOCK RESTRICTION AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                              ***

     [SIGNATURE PAGE TO AMENDED AND RESTATED STOCK RESTRICTION AGREEMENT]

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                 SEQUENOM, INC.

                          Stock Restriction Agreement

                        Series D Investor Signature Page
                        --------------------------------


     By executing this page in the space provided, the undersigned hereby agrees
(i) that it is a "Series D Investor" as defined in the Stock Restriction
Agreement dated as of December 21, 1998, by and among Sequenom, Inc. and the
parties named therein, (ii) that it is a party to the Stock Restriction
Agreement for all purposes and (iii) that it is bound by all terms and
conditions of the Stock Restriction Agreement.


     EXECUTED this 21st day of December, 1998.



                              ------------------------------------------
                              (print name)


                              By:
                                 ---------------------------------------
                              Title:
                                    ------------------------------------

                              By:
                                 ---------------------------------------
                              Title:
                                    ------------------------------------

                              Address:
                                      ----------------------------------
                              ------------------------------------------
                              ------------------------------------------

[INVESTOR SIGNATURE PAGE TO AMENDED AND RESTATED STOCK RESTRICTION AGREEMENT]
<PAGE>

                                   Exhibit A
                                   ---------

                                 SEQUENOM, INC.

                          Stock Restriction Agreement

                       Additional Investor Signature Page
                       ----------------------------------

     By executing this page in the space provided, the undersigned hereby agrees
(i) that it is an "Additional Investor" as defined in the Series D Convertible
Preferred Stock Purchase Agreement dated as of December 21, 1998 and an
"Investor" as defined in the Stock Restriction Agreement dated as of December
21, 1998 each by and among Sequenom, Inc. and the parties named therein, (ii)
that it is a party to the Stock Restriction Agreement for all purposes and (iii)
that it is bound by all terms and conditions of the Stock Restriction Agreement.

     EXECUTED this ____ day of ____________, 1999.




                              ------------------------------------------
                              (print name)


                              By:
                                 ---------------------------------------
                              Title:
                                    ------------------------------------

                              Address:
                                      ----------------------------------
                              ------------------------------------------
                              ------------------------------------------


                    [ADDITIONAL INVESTOR SIGNATURE PAGE TO
               AMENDED AND RESTATED STOCK RESTRICTION AGREEMENT]
<PAGE>

                                  EXHIBIT 4.19

                              Related Transactions
                              --------------------

     None.
<PAGE>

                                  EXHIBIT 4.20

                             Governmental Consents
                             ---------------------

     None.
<PAGE>

                                  EXHIBIT 4.23

                       Commitments from German Government
                       ----------------------------------

Description of agreements between Sequenom Instruments GmbH ("Sequenom Germany")
and with Technnologie-Beteiligungs-Gesellschaft mbH der Deutschen Ausgleichsbank
("TBG")

1.  The May 1995 "BJTU" Agreement
    -----------------------------

     TBG has provided DM 1 million silent partnership financing to Sequenom
     Germany, which matches DM 1 million of capital invested in Sequenom Germany
     by the Corporation.  The terms of the silent partnership arrangement are as
     follows:

     Interest rate of 6% on the principal amount of the silent partnership loan.
     Interest payable beginning June 30, 1997.
     Additional compensation as follows:

     .  9% of any annual profits, beginning with fiscal year 1997, if the
        profits exceed DM 100,000, up to a maximum compensation amount of 6%
        of the silent partnership loan.

     .  25% of the amount loaned is due at the end of the investment period.
        The profit shares described above, if any, are applied toward this
        additional payment. The TBG may elect to forego such payments in certain
        situations.

     Principal payment due on December 31, 2005

     This agreement has no "downside protection," which is contained in the 1995
     agreement.

2.  The December 1995 "BJTU" Agreement
    ----------------------------------

     TBG has provided DM 3 million silent partnership financing to Sequenom
     Germany, which matches DM 3 million of capital invested in Sequenom Germany
     by the Corporation.  The terms of the silent partnership arrangement are as
     follows:

     Interest rate of 6% on the principal amount of the silent partnership loan.

     Interest payable beginning June 30, 1997.

     Additional compensation as follows:

     .  9% of any annual profits, beginning with fiscal year 1997, if the
        profits exceed DM 100,000, up to a maximum compensation amount of 6% of
        the silent partnership loan.
<PAGE>

     .  30% of the amount loaned is due at the end of the investment period.
        The profit shares described above, if any, are applied toward this
        additional payment. The TBG may elect to forego such payments in certain
        situations.

     Principal payment due on December 31, 2005.

     This agreement also contains a "50 % downside protection" for the investors
     in the Inc. as follows:  Under certain circumstances, if the Corporation
     exercises its "put option" to TBG of its equity interest in Sequenom
     Germany, TBG will pay to the Inc. 50% of the amount of the silent
     partnership.

3.  The October 1997 "BJTU" Agreement
    ---------------------------------

     TBG has provided DM 2 million silent partnership financing to Sequenom
     Germany, which matches DM 2 million of capital invested in Sequenom Germany
     by the Corporation.  The terms of the silent partnership arrangement are as
     follows:

     Interest rate of 7% on the principal amount of the silent partnership loan.

     Interest payable beginning May 31, 1998.

     Additional compensation as follows:

     .  9% of any annual profits, beginning with fiscal year 1998, if the
        profits exceed DM 100,000, up to a maximum compensation amount of 7% of
        the silent partnership loan.

     .  35% of the amount loaned is due at the end of the investment period.
        The profit shares described above, if any, are applied toward this
        additional payment. The TBG may elect to forego such payments in certain
        situations.

     Principal payment due on December 31, 2007.

4.  The January 1998 "BJTU" Agreement
    ---------------------------------

     TBG has provided DM 4 million silent partnership financing to Sequenom
     Germany.  The terms of the silent partnership arrangement are as follows:

     Interest rate of 6% of Sequenom GmbH's annual profits.

     The loan may be converted to Common Stock each June or December at the
     option of the bank.  The conversion ratio is calculated as the arithmetic
     mean between $3.15 per share and the current valuation of the Common Stock
     at the time of conversion, not to exceed $8.40 per share.

     The loan must be repaid by December 31, 2007, if not previously converted.
<PAGE>

5.   The February 1998 "BJTU" Agreement
     ----------------------------------

     In February 1998, a German bank purchased 2,700 shares or approximately 5%
     of Sequenom GmbH common stock for DM 3 million (approximately $1,714,000).
     These shares can be converted to Sequenom, Inc.'s Series C Preferred Stock
     at the option of the bank.  The conversion price is $3.15 per share.
     Sequenom, Inc. can call for conversion in the case of an initial public
     offering or the exit of existing investors.

Description of the grant programs for which Sequenom Germany has received
approvals:

1.   Grant from the "Biotechnology 2000" grant scheme from the Ministry of
     Research and Technology ("BMBF"):

     The BMBF has approved a grant (which is a non-repayable contribution) in
     the amount of DM 2.2 million based on the application for the financing of
     a total research and development project of DM 4.4 million.  The grant
     coverage is therefore 50% of total estimated project cost.  The company
     will call the money quarterly in arrears based on actual cost attributable
     to the project.  The project started on September 1, 1995 and has a
     duration of three years.

2.  Grant from Freie und Hansestadt Hamburg (City of Hamburg):

     The City of Hamburg has approved a grant of DM 800,000 based on a list of
     equipment for Sequenom's laboratory to be purchased after September 1,
     1995.  Total expected cash outflows for the equipment purchases is DM 1.6
     million.  Grant coverage is also 50% of estimated cost.

Both grants do not have to be repaid.

<PAGE>

                                                                  EXHIBIT 10.10

                                SEQUENOM, INC.
                                --------------

                    NOTE SECURED BY STOCK PLEDGE AGREEMENT
                    --------------------------------------

$________________                                                         [DATE]
                                                           San Diego, California

          FOR VALUE RECEIVED, ____________("Maker") promises to pay to the order
of Sequenom, Inc., a Delaware corporation (the "Corporation"), at its corporate
offices at 11555 Sorrento Valley Road, San Diego, CA  92121, the principal sum
of ________________ ($___________), together with all accrued interest thereon,
upon the terms and conditions specified below.

          1. PURCHASE MONEY INDEBTEDNESS. The proceeds of this Note shall be
             ---------------------------
applied solely and exclusively to the payment of the purchase price of
___________shares of the Corporation's common stock acquired this day by Maker
(the "Purchased Shares") pursuant to an outstanding stock option granted under
the Corporation's 1994 and 1998 Stock Option/Stock Issuance Plan, and those
Purchased Shares shall be held in pledge by the Corporation as collateral for
the payment of this Note.

          2. INTEREST. Interest shall accrue on the unpaid balance outstanding
             --------
from time to time under this Note at the applicate federal rate of ______% per
annum, compounded annually. Accrued and unpaid interest shall become due and
payable on the date the principal balance is due.

     DUE DATES.  The principal balance of this Note shall become due and payable
     ---------
     the earlier of (i) two years from the date indicated above or ii) the time
     of the secondary offering, if at the time of the secondary offering the
     Maker is allowed to sell shares

          3. PAYMENT. Payment shall be made in lawful tender of the United
             -------
States and shall be applied first to the payment of all accrued and unpaid
interest and then to the payment of principal. Prepayment of the principal
balance of this Note, together with all accrued and unpaid interest on the
portion of principal so prepaid, may be made in whole or in part at any time
without penalty.

          4. EVENTS OF ACCELERATION. The entire unpaid principal balance of this
             ----------------------
Note, together with all accrued and unpaid interest, shall become immediately
due and payable prior to the specified due date of this Note upon the occurrence
of one or more of the following events:

             A.  the failure of the Maker to pay any installment of principal or
     accrued interest under this Note when due and the continuation of such
     default for more than thirty (30) days; or

             B. the expiration of the thirty (30)-day period following the date
     the Maker ceases for any reason to remain in the employ of the
     Corporation; or

<PAGE>

               C.  the insolvency of the Maker, the commission of any act of
     bankruptcy by the Maker, the execution by the Maker of a general assignment
     for the benefit of creditors, the filing by or against the Maker of any
     petition in bankruptcy or any petition for relief under the provisions of
     the Federal bankruptcy act or any other state or Federal law for the relief
     of debtors and the continuation of such petition without dismissal for a
     period of thirty (30) days or more, the appointment of a receiver or
     trustee to take possession of any property or assets of the Maker or the
     attachment of or execution against any property or assets of the Maker; or

               D.  the occurrence of any event of default under the Stock Pledge
     Agreement securing this Note or any obligation secured thereby.

          5.   SPECIAL ACCELERATION EVENT. In the event the Maker sells or
               --------------------------
otherwise transfers for value one or more shares of the Corporation's common
stock purchased with the proceeds of this Note, then any unpaid portion of the
principal balance of this Note attributable to the purchase price of those
shares shall become immediately due and payable, together with all accrued and
unpaid interest on that principal portion.

          6.   EMPLOYMENT. The Maker shall be deemed to continue in employment
               ----------
with the Corporation for so long as he or she renders services as an employee of
the Corporation or one or more of the Corporation's fifty percent (50%) or more
owned (directly or indirectly) subsidiaries.

          7.   SECURITY. Payment of this Note shall be secured by a pledge of
               --------
the Purchased Shares with the Corporation pursuant to the Stock Pledge Agreement
to be executed this date by the Maker. The Maker, however, shall remain
personally liable for payment of this Note and assets of the Maker, in addition
to the collateral under the Stock Pledge Agreement, may be applied to the
satisfaction of the Maker's obligations hereunder.

          8.   COLLECTION. If action is instituted to collect this Note, the
               ----------
Maker promises to pay all costs and expenses (including reasonable attorney
fees) incurred in connection with such action.

          9.   WAIVER.  A waiver of any term of this Note, the Stock Pledge
               ------
Agreement or of any of the obligations secured thereby must be made in writing
and signed by a duly-authorized officer of the Corporation and any such waiver
shall be limited to its express terms.

          No delay by the Corporation in acting with respect to the terms of
this Note or the Stock Pledge Agreement shall constitute a waiver of any breach,
default, or failure of a condition under this Note, the Stock Pledge Agreement
or the obligations secured thereby.

          The Maker waives presentment, demand, notice of dishonor, notice of
default or delinquency, notice of acceleration, notice of protest and
nonpayment, notice of costs, expenses or losses and interest thereon, notice of
interest on interest and diligence in taking any action to

                                       2.
<PAGE>

collect any sums owing under this Note or in proceeding against any of the
rights or interests in or to properties securing payment of this Note.

          10.  CONFLICTING AGREEMENTS. In the event of any inconsistencies
               ----------------------
between the terms of this Note and the terms of any other document related to
the loan evidenced by the Note, the terms of this Note shall prevail.

          11.  GOVERNING LAW.  This Note shall be construed in accordance with
               -------------
the laws of the State of California without resort to that State's conflict-of-
laws rules.




                                            ____________________________________
                                                            MAKER

                                      3.
<PAGE>

                                  SCHEDULE A
                                  ----------

                Form of Note Secured by Stock Pledge Agreement.
                ----------------------------------------------

- ----------------------------------------------------------------------
                                  Principal    Purchase
Date of Note    Maker                Sum        Shares       Interest
- ----------------------------------------------------------------------
10/06/99        Hubert Koster      $611,631     680,000       6.02%
- ----------------------------------------------------------------------
10/05/99        Steve Zaniboni     $143,346     210,000       6.02%
- ----------------------------------------------------------------------
10/09/99        Antonius Schuh     $160,418     280,000       6.02%
- ----------------------------------------------------------------------
09/13/99        Charles Cantor     $468,901     351,000       5.98%
- ----------------------------------------------------------------------
07/01/99        Andreas Braun      $ 42,380     120,000       5.82%
- ----------------------------------------------------------------------

<PAGE>

                                                                   EXHIBIT 10.12


                              INVESTMENT CONTRACT

         Agreement concerning the Establishment of a Silent Partnership
                                    between
            SEQUENOM Instruments GmbH, Stapelstr. 5B, 22529 Hamburg
         hereinafter referred to as : Young Technology Company ("YTC")
                                      and
                  Technologie-Beteiligung-Gesellschaft m.b.H.
             of Deutsche Ausgleichsbank, Wielandstr. 4, 53170 Bonn
                    - hereinafter: Silent Partner ("tbg") -


                                     (S) 1

                    Objectives of the Partnership, Partners

1.   Within the scope of the pilot programme "Equity capital for young
     technology enterprises" carried out with the Federal Minister of Education,
     Science, Research and Technology (BMBF) and Deutsche Ausgleichsbank, tbg
     promotes young technology enterprises by making investments for the funding
     of investments and operating assets

     -    for research and development work up to the manufacture and testing of
          prototypes (germination phase), and

     -    for adaptation developments and the preparation of production,
          including the market introduction of innovative technological
          products, processes or services (buildup phase).

2.   a)   According to the Articles of Incorporation in their valid version
     dated Nov. 10, 1994, the YTC, which is registered under No. B 57315 in the
     Company Roll of the District Court of Hamburg, operates a commercial
     enterprise with the aim of:

     Development, production and marketing of devices for the sequencing of DNA,
     sale of sequencing information, and development of medical diagnostics and
     therapeutics.

     b)   In accordance with this objective of the enterprise, the YTC is
     engaged in the new development and integration of DNA-related chemical,
     molecular-biology and physical processes for the production of a functional
     model of a patented, automated DNA sequencing instrument, specifically for
     the sequencing of the human genome.

3.   tbg invests in the YTC in the legal form of a silent partnership with the
     intention of promoting the objectives described under Section 2(b) above.

                                     (S) 2

                               Capital Injection
<PAGE>

1.   For the exclusive use of promoting the innovative project described under
     (S) 1 Section 2(b), and based upon the information provided by the YTC in
     the Application for Investment dated Nov. 28, 1994, tbg makes an investment
     in the amount of DM 1,000,000.--, provided that the YTC can document an
     investment of DM 1,000,000 by SEQUENOM Inc., Boston, c/o TVM Techno Venture
     Management L.P., 101 Arch , Street, Boston MA 021 10, USA (referred to as
     Associated Company "AC" in the following), and that the AC has concluded a
     cooperation agreement with tbg.

     The AC will consult TVM Techno Venture Management Gesellschaft mbH & Co.
     KG, Leopoldstr. 28 A, 80802 Munich, regarding the management of the
     investment.

2.   The injection by tbg shall be used for the co-financing of the investment
     and financing schedule described in the annex.  The annex constitutes an
     integral part of this Investment Agreement.

     In the event that the project costs are reduced vis-a-vis those above
     stated, or if additional public funding is acquired retroactively, tbg is
     entitled to reduce its injection respectively in the proportion by which
     the investment volume is reduced.  The amount by which the injection is
     reduced shall be returned to tbg at once.

3.   The YTC is entitled to draw down the capital after the company becomes
     operational (cf. (S)3, Section 1), provided that its immediate designated
     utilisation and a proportional use of funds together with the other means
     of financing foreseen in Section 2 are guaranteed.  The withdrawal must
     have appended a confirmation by the AC that the prerequisites for the
     withdrawal have been met.

4.   This Agreement shall expire in the event that the capital is not drawn
     down, at least in part, latest by Sept. 31, 1995. [can that be an error in
     the contract?]

5.   tbg is entitled to withhold a processing fee in the amount of I % of the
     total injection specified in this Agreement.  Such fee will be withheld
     from the first partial withdrawal.

6.   The YTC shall establish a separate desposit account for the injection by
     tbg.  Withdrawals from this account by tbg are precluded.

                                     (S) 3

                   Beginning and Lifetime of the Partnership

1.   The Silent Partnership shall commence as soon as both parties have signed
     this Contract.

2.   The Silent Partnership shall terminate on Dec. 31, 2005.

3.   tbg's capital and any outstanding profit shares shall be due for payment to
     tbg upon termination of the Partnership.

4.   In the event that the funds invested by the AC are repaid before Dec. 31,
     2005, the investment made by tbg shall be repayable at the same time and to
     the same extent.

                                       2
<PAGE>

                                     (S) 4

                                  Management

1.   tbg shall have no control in the management of the YTC insofar as not
     stipulated otherwise in the following.

2.   The YTC shall obtain the approval of tbg in respect of:

     (a)  any amendment to the Articles of Incorporation, in particular any
          modification of the purpose of the company, acceptance of new
          shareholders, or agreement of new investments;

     (b)  the appointment and dismissal of executive managers of the YTC;

     (c)  the conclusion, amendment and termination of contracts governing the
          granting or acquisition of licences, patents, prototypes, samples,
          trademarks or know-how insofar as they relate to the innovation
          project promoted by tbg;

     (d)  the conclusion, amendment and termination of major sales contracts;

     (e)  the partial or entire relocation, leasing or sale of the operation;

     (f)  the conclusion and termination of control and profit pooling
          contracts.

3.   Approval in accordance with (S) 4, Section 2, shall be obtained directly
     from tbg.

     Insofar as tbg fails to give written notice of its refusal of approval
     within a period of 14 days after receipt of the notification advising it of
     the measure requiring approval, such approval shall be deemed as given.

                                     (S) 5

                             Reporting and Control

1.   The YTC shall report to tbg semi-annually, by March 31 and September 30,
     respectively, the financial situation of the YTC and the status of the
     innovation project described in (S) 1, Section 2b, until such time when tbg
     waives such reports, because the AC exercises control of the YTC also on
     behalf of tbg.  In addition, the YTC shall file with tbg brief monthly
     status reports in the form appended hereto.

2.   Regardless whether the AC exercises control in the YTC also on behalf of
     tbg, the YTC shall notify tbg directly immediately of all measures
     exceeding the scope of the normal business transactions.  In addition to
     the measures defined in (S) 4, Section 2, measures exceeding the scope of
     business transactions include specifically:

     (a)  Partial or complete stoppage of operations;

                                       3
<PAGE>

     (b)  Abandonment or substantial modifications of the innovation project
          described in (S) 1, Section 2;

     (c)  The entering into commitments, also for investments, in excess of DM
          150,000.- or, insofar as such commitments arise from lease, rental, or
          leasehold contracts, in excess of DM 50,000.-- per month, and are not
          stated in the present business plan.

3.   Furthermore, tbg is entitled to exercise its rights of control in
     accordance with (S) 716 of the German Civil Code.  This shall apply also
     after termination of the Partnership to the extent required for the
     verification of the funds to be distributed.

     tbg is further entitled the review all the documentation of the YTC
     pertaining to the innovation project described in (S) 1, Section 2b.  To
     exercise its rights of control, tbg is entitled to avail itself of the
     services of third parties.

4.   The YTC concedes to BMBF and its designated representative the rights to
     presentation, information and inspection to the same extent as conceded to
     tbg.  The YTC entitles tbg to forward for scientific evaluation of the
     model test described in (S) 1, Section 1, of this Agreement all data
     concerning its enterprise and the promoted innovation project to BMBF or an
     institute designated by BMBF.  It agrees further, to disclose directly also
     to BMBF and an institute designated by BMBF all information required for
     the scientific evaluation of the model programme.  In the event of the
     processing and/or publication of data concerning the programme it shall be
     ensured that the YTC incurs no damages.

5.   Upon request, the YTC shall furnish tbg with all documentation deemed
     necessary by the Department of the AuditorGeneral for the purpose of audit.

                                     (S) 6

                                 Advisory Board

tbg may at any time request the establishment of an advisory board.

tbg shall participate in this board to an extent commensurate with the amount of
its capital.

The advisory board shall advise the YTC concerning commercial and technical
issues, in particular with regard to the project described in (S) 1, Section 2b.
The board shall be entitled to the same rights to information and control as
they are granted to tbg under this Agreement.

                                     (S) 7

                        Financial Year, Annual Accounts

1.   The financial year of the Silent Partnership concurs with the financial
     year of the YTC.  The financial year of the YTC shall end on 31 December of
     each year.

2.   The YTC shall prepare its annual financial statements (balance sheet,
     profit and loss account, notes) in accordance with (S)(S) 238-289 of the
     Code of Commercial Law within

                                       4
<PAGE>

     six months after the end of the financial year and shall submit one signed
     original specimen together with the confirmation of a certified public
     accountant or auditor.

3.   If admissible under the Code of Commercial Law, the annual financial
     statements shall comply with the regulations for profit calculation in
     accordance with the income tax law.  In the event that values other than
     those given in the original financial statements are determined in
     accordance with tax regulations, or based upon a tax audit, these shall be
     valid also for the relationship between the YTC and tbg.

                                     (S) 8

                            Profit and Loss Sharing

1.   tbg shall receive on its capital, irrespective of the YTC's annual
     earnings, a minimum return of 6 % p.a. This shall be payable retroactively
     every six months, on March 31 and September 30 of each year, the initial
     payment falling due on 30 June 1997.

2.   In the event that the YTC's annual profits from the date of draw down of
     the deposit exceed DM 100,000.--, but for the first time in financial year
     1997, tbg shall receive 9 % p.a. of such profits, but not more than 6 % of
     the actual capital injected.

     For such time as tbg holds more than one share in the YTC, however, it
     shall receive in addition to the respective minimum-compensation only 9 %
     in total for all investments, but not more than a maximum of 7 % of the
     total capital injected.

     This share in profits is payable within two weeks after approval of the
     financial statements ((S)7, Section 2) by the shareholders.

3.   The calculations as per Section 2 shall be based on annual profits as per
     the financial statements prepared in accordance with (S) 7, Section 3,
     prior to the consideration of the profit share of tbg according to the
     preceding Section 2.

     a)  The following shall be added to the annual profits:

          -    Taxes paid on profits insofar as they reduced annual profits
               shown;

          -    If the YTC is a partnership, interest debited to the shareholders
               of the YTC not taken into account in arriving at the annual
               profits of the Partnership;

          -    Extraordinary expenditure insofar as it is incurred from.
               business transacted prior to the beginning of the Silent
               Partnership;

          -    Losses caused by the sale or destruction of property, plant and
               equipment insofar as the latter had already existed at the time
               of the beginning of the Partnership.

     b)   The following shall be deducted from the annual profits:

                                       5
<PAGE>

          -    Funds from the release of tax-free reserves set up prior to the
               beginning of the Silent Partnership;

          -    Compensation for services or interest credited to the YTC's
               shareholders, insofar as the YTC is a partnership, without having
               reduced the taxable profits of the Partnership;

          -    Extraordinary revenues insofar as they relate to business
               transacted prior to the beginning of the Silent Partnership;

          -    Revenues from the sale of property, plant and equipment insofar
               as such goods had already existed at the time of the beginning of
               the Partnership.

     c)   In the year in which the deposit is drawn down, the annual profit for
          the calculation of the profit sharing in accordance with Section 2
          shall be deemed to have occurred evenly throughout the year.

4.   tbg shall be entitled to demand at the end of the lifetime of the
     investment a one-off remuneration of 25 % of the total of the investment,
     plus an additional 6 % of the investment for each year after the end of the
     fifth full year of the Partnership during which tbg was not given a share
     in the profits according to (S)8, Section 2.

     tbg shall exercise this right only in the event that it deems such
     remuneration justified in view of the overall financial situation of the
     YTC, especially in view of its profits achieved in the last three years
     prior to the termination of the investment and the hidden reserves
     accumulated during the lifetime of the investment.

5.   tbg shall not share in any losses of the YTC.

                                     (S) 9

                                     Taxes

The YTC shall be responsible for the payment of the legally prescribed
withholding tax, plus the Solidarity levy, in respect of the remuneration for
the capital provided, and shall withhold from the respective payments to tbg the
withholding tax and the Solidarity levy and shall remit this directly to the
relevant tax office.  Following such remittance, the YTC shall furnish tbg with
the respective certificates in accordance with (S) 45a, para. 2 of the Income
Tax Law, using the blank forms provided by tbg.

                                     (S) 10

                         Sale and Acquisition of Shares

1.   tbg is entitled to sell its investment either in part or entirely to the AC
     or a cooperation partner succeeding the AC.

                                       6
<PAGE>

     The cooperation partner is entitled to demand at the end of each financial
     year that the silent partnership holding which he took over from tbg be
     converted into a liable share in the company.  The conditions for such
     conversion shall be agreed between the YTC and the AC.

2.   tbg is furthermore entitled to take itself the share of another company
     participating in the YTC with which tbg has made a cooperation agreement,
     or demand its transfer to a third party to be nominated by tbg.

                                    (S) 11

                     Dissolution of the Silent Partnership

1.   The Silent Partnership shall be dissolved in the event that the YTC is
     liquidated.

2.   (S) 3, Section 3 and (S) 8, Section 4 shall be applicable also in this
     event.

                                     (S) 12

                                     Notice

1.   The YTC is entitled to redeem the shares of tbg entirely or in part at 3
     months' notice as per June 30 or December 31 of each year.  Where such
     redemption is effected before the end of the fifth full year of the
     investment, the capital of tbg shall be paid back with a premium of 25 %.
     From the beginning of the sixth year of the investment, (S) 8, Section 4
     shall apply. tbg may waive payment of the premium if the notice of
     redemption is given for the reason that the promoted innovation project is
     abandoned.

2.   Furthermore, the Silent Partnership may be dissolved for important reason
     with immediate effect by either of the Partners with written notice.  In
     the event that the capital has not yet been paid in either fully or in
     part, tbg shall be released from its commitment to make an injection with
     effect from the date of such notice.

     tbg has the right to give notice for important reasons, in particular in
     the event that

     a)   the YTC made false representations in the Investment Application;

     b)   it becomes evident that the prerequisites upon which the investment
          was undertaken did not exist, or that the prerequisites for continuing
          the investment have are no longer fulfilled, in particular if the
          innovation project described in (S) 1, Section 2b, proves non-feasible
          or is abandoned by the YTC or is substantially modified. In the event
          that the innovation project described in (S) 1, Section 2, proves to
          be nonfeasible in technical or financial terms, tbg may waive
          repayment of the investment wholly or in part if by such waiver the
          YTC can continue its operations;

                                       7
<PAGE>

     c)   any bill of exchange accepted by the YTC is disputed, the YTC stops
          payments, or the YTC instigates bankruptcy proceedings, or settlement
          proceedings are opened in court, or insolvency is declared in any
          other form;

     d)   the senior specialist or specialists possessing the know-know at the
          time of the conclusion of the Investment Agreement is/are no longer
          full-time members of the management of the YTC;

     e)   one of the measures defined in (S) 4, Section 2 is implemented without
          the prior consent of tbg, and such measure jeoparized the existence
          of the company or the implementation of the promoted innovation
          project.

                                    (S) 13

                                  Payments due

All payments due shall incur interest at the rate of 4 % p.a. from the effective
date of default until the time of receipt by tbg.

                                    (S) 14

                              General Provisions

1.   Amendments or supplements to this Agreement must be in writing.  Any
     supplementary verbal agreements relating to this Agreement shall be
     invalid.

2.   In the event that one provision of this Agreement becomes invalid, this
     shall not affect the validity of any other provision.  The YTC and tbg
     undertake to replace invalidated provisions by legally valid clauses that
     reflect to the greatest possible extent the sense and purpose of the
     invalid provisions.

3.   Bonn shall be the legal venue for all disputes that may arise from this
     Agreement or its execution.

Bonn, June 23, 1995                             Hamburg, May 18, 1995
Technologie-Beteiligungs-                       SEQUENOM
Gesellschaft mbH der                            Instruments GmbH
Dcutschcn Ausglcichsbank
(signed)  (signed)                              (signed: Helmut Schuhsler)
(Signatures illegible)

                                       8
<PAGE>

                          COST AND FINANCING SCHEDULE

                           for the Period 1995 - 1996

                                 Cost Schedule

<TABLE>
<CAPTION>
- -------------------------------------------------------------------------------------------------
             Investments                                 Operating Costs
<S>                   <C>                      <C>                      <C>
Furnishings              200,000               Wages/Salaries           1,500,000 DM
DM                                             Supplies                 200,000 DM
Equipment              1,200,000               Sundry                   100,000 DM
- -------------------------------------------------------------------------------------------------
DM
- -------------------------------------------------------------------------------------------------
Total                  1,400,000               Total                    1,800,000 DM
DM
                             Expenditures Total:   3,200,000 DM
- -------------------------------------------------------------------------------------------------
</TABLE>

                                 Financing Plan


<TABLE>
<CAPTION>
- ----------------------------------------------------------------------------------------------
             Investments                                 Operating Costs
- -----------------------------------------------------------------------------------------------
<S>                   <C>                      <C>                      <C>
Own resources                                    Own resources               50,000 DM
tbg                     500,000                  tbg                        500,000 DM
DM                                               Lead investor              500,000 DM
Lead investor           500,000                  Grants/subsidies           750,000 DM
DM
Grants/subsidies        400,000
DM
- -------------------------------------------------------------------------------------------------
Total                 1,400,000                  Total                    l,800,000 DM
DM
          Financing Total                                   3,200,000 DM
- -------------------------------------------------------------------------------------------------
</TABLE>

                                       9

<PAGE>

                                                                   EXHIBIT 10.13

                             COOPERATION AGREEMENT
                      Agreement for a cooperation between

SEQUENOM Inc., Boston, c/o TVM Techno Venture Management L.P., 101 Arch Street
                             Boston, MA 02110, USA

                 - in the following: participation partnership
                       (Beteiligungsgesellschaft: BG )-

      and the Technologie Beteiligungs Gesellschaft mbH of the Deutsche
                                Ausgleichsbank,
                           Wielandstr. 4, 53170 Bonn
                           - in the following: tbg -

   with the maintenance of the participations mentioned in this agreement in
          SEQUENOM Instruments GmbH, Stapelstrasse 5B, 22529 Hamburg

           - in the following: Junges Technologie-Unternehmen (JTU)

                                     (S) 1

                           PARTIES TO THE AGREEMENT

1.   Within the scope of the pilot project "Participation Capital for Start-Up
     Technology-Companies" carried out by the Bundesminister fur Bildung,
     Wissenschaft, Forschung und Technologie (BMBF) (Federal Ministry for
     Education, Science, Research and Technology) and the Deutsche
     Ausgleichsbank, tbg supports start-up technology-companies by participating
     in their investment- and operations financing for

     -research and development up to the production and testing of prototypes
     (seed stage) and

     -assimilation development and preparation for production including market
     introduction of new technical products, procedures or technical services
     (development stage).

     tbg intends to take over a silent participation in the amount of DM
     1,000,000.-- in the JTU, provided that the participation between BG and JTU
     mentioned in section 2 will be agreed upon.  A copy of the agreement of the
     assigned participation agreement between tbg and JTU is attached to this
     agreement.

2)   BG intends to take over for JTU a participation in the amount of DM
     950,000.-- as non-refundable partnership contribution and an original
     investment in the amount of DM 50,000.--.

     BG will be consulted in the management of its participation by TVM Techno
     Venture Management Gesellschaft mbH & Co. KG, Leopoldstrasse 28 A, 80802
     Munchen (in the following: TVM).

<PAGE>

     BG confirms that it neither applied for refinancing, of a participation in
     JTU in the scope of the trial "participation asset for start-up technology
     companies" with KfW, nor for the rest lays claim to the promotion
     (refinancing or deposition) of this participation in JTU from the ERP
     special assets.

3)   The parties shall immediately inform each other in writing , when the
     mentioned participation arrangements with JTU are finalized. If the final
     participation agreements differ from the draft notifications, the
     agreements are to be consigned in the standard version and differences are
     to be explained on request.

4)   The parties shall only with the consent of their party to this agreement
     agree upon subsequent changes of the participation agreements, sale /
     mortgaging of the participations or further participation- or loan
     agreements. As far as a proper termination of the participation agreement
     between BG and JTU is permissible to BG, then it will require the consent
     of tbg. The parties of this agreement have to inform each other immediately
     about a termination for an urgent reason, if possible before the
     declaration of the termination.

                                     (S) 2

                               MANAGEMENT OF JTU

BG, in collaboration with TVM, will control with the necessary care the
management of JTU and the development of the innovation scheme promoted by tbg
and assist JTU, if required, with management support.  Fundamentally, BG is
willing and in a position, but not obliged, to make additional means of
financing available to JTU, if needed.

                                     (S) 3

                                USE OF RESOURCES

Before the call off of means of participations of tbg, BG will verify the agreed
upon call off assumptions between tbg and and JTU and, as far as they exist,
confirm them.  BG will support the call off, if there are neither economical nor
technical objections regarding, the realization of the innovation plan promoted
by tbg at the time of the call off and after their knowledge.

                                     (S) 4

                         INFORMATION AND CONTROL RIGHTS

1)   BG obliges itself with tbg to the reporting about the economic situation of
     JTU and about the position of the innovation plan promoted by tbg.
     Therewith BG will lay claim to the consulting services of TVM.

2)   Reports are to be made regularly half-yearly up to March 31 and up to
     September 30.

3)   An immediate and if possible a preceding report of tbg has to result by
     means of all measures known to BG that excede the normal management of JTU.
     These are in

                                       2
<PAGE>

     particular the measures in need of consent, that according to (S) 4 of
     the participation agreement between tbg and JTU and the reasons mentioned
     in (S) 12 of the participation agreement for a termination due to an urgent
     reason.

4)   The report shall be made in writing, and in urgent cases mainly orally,
     provided that tbg does not renounce this explicitly in writing.

5)   tbg is entitled to request on its own or through a designated third party
     extensive information about all legal relations of BG with JTU and to
     inspect at BG all documents regarding JTU.

6)   BG agrees that tbg conveys the data obtained, regarding the participation
     of BG with JTU for the scientific evaluation of the pilot project
     (Modellversuch) mentioned in (S) 1, section 1 of this agreement, to BMBF or
     to an appointed institution. Moreover, BG agrees to provide immediately the
     information, required for the scientific evaluation of the pilot project,
     to BMBF and to an appointed institution. With regard to the evaluation and
     if need be with regard to the publication of data about the pilot project,
     it will be secured (guaranteed) that BG will suffer no damages.

                                     (S) 5

                                 BUYER'S OPTION

1)   BG is entitled to take over the shares of tbg in JTU on 6/30 or 12/31 of
     each year, the latest, however, on the deadline that follows the expiration
     of three years from the beginning of the participation of tbg in JTU. The
     request for takeover by BG has to be declared in writing against tbg one
     calender month prior to the date of the takeover determined by BG.

2)   BG takes over the participation (shares) of tbg in external proportions
     (Aussenverhaltnis) with all rights and obligations. In internal proportions
     (Innenverhdltnis) tbg will be participating in the proceeds from the
     current business year of the participation with 1/12 for every month (that
     has begun) of its participation. For the accounting between tbg and BG the
     amounts of the corresponding business year count as accrued distributed
     over all months evenly. Payments of JTU that were made to tbg are to be
     considered.

3)   The takeover of the participation of tbg is made at the nominal amount of
     the participation of tbg at the time of the takeover in addition to a
     surcharge of 25 %. The takeover price is due for payment to tbg 2 weeks
     after takeover.

4)   In the participation agreement between tbg and JTU the rights have been
     reserved for BG in the form discussed with BG in case of the execution of
     this option to request the conversion of the silent participation into a
     corporate share.

                                     (S) 6

                   BEGINNING AND DURATION OF THE COOPERATION

                                       3
<PAGE>

1)   BG is obliged towards tbg with the care of JTU according to (S) 2 and with
     the informing according to (S) 4 of this agreement from the time when this
     agreement and the participation agreements between tbg and JTU, as well as
     BG and JTU have been signed.

2)   The cooperation ends with the termination of the participation of tbg or
     BG.

3)   The proper termination of this cooperation agreement is excluded.

                                     (S) 7

                              GENERAL PROVISIONS

1)   Amendments and supplements of this agreement are needed in writing. Oral
     agreements on the side of this agreement do not exist.

2)   If one provision of this agreement is legally ineffective, then the other
     provisions are not affected by it. BG and tbg are obliged to replace
     ineffective provisions of agreement by regulations that are legally
     effective and that are corresponding in idea and purpose to the legally
     ineffecfive provisions as far as possible.

3)   Bonn has been agreed upon as legal domicile for all legal disputes
     resulting from this agreement and its realization.

Bonn,                                         Boston

Technologie-Beteiligungs-                     SEQUENOM Inc., Boston
Gesellschaft m. b. H. der                     c/o TVM Techno Venture Management
Deutschen Ausgleichsbank                      101 Arch Street
                                              Boston, MA  02110
                                              USA

                                       4

<PAGE>

                                                                               1


                                                                   EXHIBIT 10.14
                              INVESTMENT CONTRACT

        Agreement concerning the Establishment of a Silent Partnership

                                    between

         SEQUENOM Instruments GmbH, Mendelssohnstr. 15d, 22761 Hamburg

            - hereinafter referred to as Technology Company (TC) -

                                      and

                   Technologie-Beteiligungs-Gesellschaft mbH

             of Deutsche Ausgleichsbank, Wielandstr. 4, 53170 Bonn

              - hereinafter referred to as Silent Partner (tbg) -


                                     (S) 1

                    Objectives of the Partnership, Partners

1.   Within the programme "Shareholders' equity for small technology companies"
     carried out with the Federal German Ministry of Education, Science,
     Research and Technology (BMBF) and Deutsche Ausgleichsbank, tbg supports
     commercial technology companies, provided they are not older than 10 years
     and comply with the EU definition of small and medium enterprises (SME) in
     the new Federal States and Berlin (East) or are small enterprises in the
     other Federal States, i.e.

     -  have no more 50 (50) employees, and
     -  have either
        -  an annual turnover more than 40 million DM (10 million DM), or
        -  total assets of not more than 20 million DM (4 million) DM, and
     -  in which not more than 25% of the share capital is owned by one or
        several companies not meeting one of several of these criteria
        (exception: public investment corporations, venture capital companies
        and institutional investors insofar as they have no control in the
        enterprise).

     All three conditions must be met simultaneously, i.e. an enterprise
     qualifies as SME only if it is independent specified, does not have more
     than the defined number of employees, and does need at least one of the
     ceiling values for annual turnover and/or total assets.
<PAGE>

                                                                               2

     tbg participates in the financing of innovations in accordance with the
     investment principles of tbg which are a constituent part of this Agreement
     and to which the TC has agreed, namely:

     - for applied research and development up to a logical instant prior to the
       start-up of commercial production in accordance with the EU definition,
       with the following delimitations:

     Applied research comprises research and experimental work with the
     objective of obtaining new insights to facilitate the achievement of
     specific, practical goals such as creation of new products, production
     processes or services.  As a rule, it will terminate with the creation of a
     first prototype.  Development comprises work based on the applied research
     with the aim of introducing innovative, or substantially improved products,
     production processes or services up to, but not including, industrial
     application and commercial use.  This stage normally includes pilot and
     demonstration projects as well as required additional development work,
     ultimately resulting in a package of information permitting the start-up of
     production.

     - for investments for introduction into the market.

2.   a)   According to the Articles of Incorporation in their valid version
          dated Nov. 10, 1994, the TC, which is registered under No. B 57315 in
          the Company Roll of the District Court of Hamburg, operates a
          commercial enterprise with the aim of:

          Development, production and marketing of devices for the sequencing of
          DNA, sale of sequencing information, and development of medical
          diagnostics and therapeutics.

     b)   In accordance with these Articles of Incorporation, the TC is engaged
          in the Development of a technology for the diagnosis of genetic
          defects.

3.   tbg participates in the TC in the legal form of a silent partnership with
     the intention of promoting the objectives described under Section 2(b)
     above.

                                     (S) 2

                               Capital Injection

1.   For the exclusive use of promoting the innovative project described under
     (S) 1 Section 2(b), and based upon the information provided by the TC in
     the Application for Investment dated 30 June 1995, tbg makes an injection
     of DM 3,000,000.-, provided that the TC substantiates the following agreed
     investment conditions:

     Investment of DM 3,000,000.-- by SEQUENOM, Inc., Boston, c/o TVM Techno
     Venture  Management L.P., 101 Arch Street, Boston MA 02110, USA (referred
     to as Associated Company - "AC" in the following), and the AC has signed a
     Cooperation Agreement with tbg.
<PAGE>

                                                                               3

     The AC will consult TVM Techno Venture Management Gesellschaft mbH & Co KG,
     Leopoldstr. 28 A, 80802 Munich concerning the management of the investment
     in the TC.

2.   The injection by tbg shall be used for the co-financing of the project
     related planning as specified in the annex.  The annex constitutes an
     integral part of this Investment Agreement.

     In the event that the project costs are reduced vis-a-vis those above
     stated, or if additional public funding is acquired retroactively, tbg is
     entitled to reduce its injection respectively in the proportion by which
     the investment volume is reduced.  The amount by which the injection is
     reduced shall be returned to tbg at once.

3.   The TC is entitled to draw down the capital after the company becomes
     operational (cf. (S)4, Section 1), provided that its immediate designated
     utilization and a proportional use of funds together with the other means
     of financing foreseen in Section 2, and overall financing of the investment
     project are guaranteed.  The withdrawal must have appended a confirmation
     by the AC that the withdrawal prerequisites have been met.

4.   This Agreement shall expire in the event that the capital is not drawn
     down, at least in part, latest by June 30, 1996.

5.   tbg is entitled to withhold a processing fee in the amount of 1% of the
     total injection specified in this Agreement.  Such fee will be withheld
     from the first partial withdrawal.

6.   The TC shall establish a separate deposit account for the injection by tbg.
     Withdrawals from this account by tbg are precluded.

                                     (S) 4

                             Proof of Utilisation

The TC shall confirm the designated use of the capital on the form also appended
to this Agreement, within 3 months after termination of the project period as
stipulated in this Agreement, unless such period is extended by tbg.  The
confirmation of use shall be submitted to tbg via the AC.  The TC shall document
the designated use upon request by the AC and tbg.

                                     (S) 4

                   Beginning and Lifetime of the Partnership

1.   The Silent Partnership shall commence as soon as both parties have signed
     this Agreement.

2.   The Silent Partnership shall terminate on December 31, 2005.

3.   Repayment of tbg's capital and of any outstanding profit shares shall
     become due upon termination of the Partnership.
<PAGE>

                                                                               4

4.   In the event that the funds granted by the AC are repaid before December
     31, 2005, repayment of the tbg deposit shall be due at the same time and in
     the same proportion.

                                     (S) 5

                                  Management

1.   tbg shall have no control in the management of the TC insofar as not
     stipulated otherwise in the following.

2.   The TC shall obtain the approval of tbg in respect of:

     (a)  any amendment to the Articles of Incorporation, in particular any
          modification of the purpose of the company, acceptance of new
          shareholders, or agreement of new investments;

     (b)  the appointment and dismissal of executive managers of the TC;

     (c)  the conclusion, amendment and termination of contracts governing the
          granting or acquisition of licences, patents, prototypes, samples,
          trademarks or know-how insofar as they relate to the innovation
          project promoted by tbg;

     (d)  the conclusion, amendment and termination of major sales contracts;

     (e)  the partial or entire relocation, leasing or sale of the operation;

     (f)  the conclusion and termination of control and profit pooling
          contracts.

3.   Approval in accordance with (S) 5, Section 2, shall be obtained directly
     from tbg.  Insofar as tbg fails to give written notice of its refusal of
     approval within a period of 14 days after receipt of the notification
     advising it of the measure requiring approval, such approval shall be
     deemed as given.

                                     (S) 6

                             Reporting and Control

1.   The TC shall report to tbg semi-annually, by March 31 and September 30,
     respectively, the financial situation of the TC and the status of the
     innovation project described in (S) 1, Section 2b, until such time when tbg
     waives such reports, because the AC exercises control of TC also on behalf
     of tbg.  In addition, the TC shall file with tbg brief monthly status
     reports in the form appended hereto.

2.   Regardless whether the AC exercises control in the TC also on behalf of
     tbg, the TC shall notify tbg directly and immediately of all measures
     exceeding the scope of the normal business transactions.  In addition to
     the measures defined in (S) 5, Section 2, measures exceeding the scope
     normal business transactions include specifically:
<PAGE>

                                                                               5

     (a)  Partial or complete stoppage of operations;

     (b)  Abandonment or substantial modifications of the innovation project
          described in (S) 1, Section 2;

     (c)  The entering into commitments, also for investments, in excess of DM
          150,000.- or, insofar as such commitments arise from lease, rental, or
          leasehold contracts, in excess of DM 50,000.-- per month, and are not
          stated in the present business plan.

3.   Furthermore, tbg is entitled to exercise its rights of control in
     accordance with (S) 716 of the German Civil Code.  This shall apply also
     after termination of the Partnership to the extent required for the
     verification of the to be distributed.

     tbg is further entitled to review all the documentation of the TC
     pertaining to the innovation project described in (S) 1, Section 2. To
     exercise its rights of control, tbg is entitled to avail itself of the
     services of third parties.

4.   The TC concedes to BMBF and its designated representative the rights to
     presentation, information and inspection to the same extent as conceded to
     tbg.  The TC entitles tbg to forward for scientific evaluation of the
     programme described in (S) 1, Section 1, of this Agreement all data
     concerning its enterprise and the promoted innovation project to BMBF or an
     institute designated by BMBF.  It agrees further, to disclose directly also
     to BMBF and an institute designated by BMBF all information required for
     the scientific evaluation of the programme, if necessary also after
     termination of the Silent Partnership.  The BMBF is entitled to forward the
     disclosed data to the EU Commission to enable the Commission to exercise
     the right of supervision and control.  In the event of the processing
     and/or publication of data concerning the programme it shall be ensured
     that the TC incurs no damages.

5.   In accordance with (S) 91 of the Federal Budget Law the Federal Auditor
     General's Department has a right to inspection.  For the purposes of
     inspection the TC will furnish the Federal Auditor General's Department and
     tbg with all documents deemed necessary by the Federal Auditor General's
     Department and disclose respective information.

                                     (S) 7

                                Advisory Board

tbg may at any time request the establishment of an advisory board.
tbg shall participate in this board to an extent commensurate with the amount of
its capital.

The advisory board shall advise the TC concerning commercial and technical
issues, in particular with regard to the project described in (S) 1, Section 2b.
The board shall be entitled to the same rights to information and control as are
granted to tbg under this Agreement.
<PAGE>

                                                                               6

                                     (S) 8

                        Financial Year, Annual Accounts

1.   The financial year of the Silent Partnership concurs with the financial
     year of the TC.  The financial year of the TC shall end on 31 December of
     each year.

2.   The TC shall prepare its annual financial statements (balance sheet, profit
     and loss account, notes) in accordance with (S)(S) 238-289 of the Code of
     Commercial Law within six months after the end of the financial year and
     shall submit one signed original specimen to tbg together with the
     confirmation of a certified public accountant or auditor.

3.   If admissible under the Code of Commercial Law, the annual financial
     statements shall comply with the regulations for profit calculation in
     accordance with the income tax law.

                                     (S) 9

                            Profit and Loss Sharing

1.   tbg shall receive on its capital, irrespective of the TC's annual earnings,
     a minimum return of 6% p.a. This shall be payable retroactively every six
     months, on March 31 and September 30 of each year, the initial payment
     falling due on 30 June 1997.

2.   In the event that the TC's annual profits from the date of draw down of the
     capital exceed DM 100,000.--, but for the first time in financial year
     1997, tbg shall receive 9% p.a. of such profits, but not more than 6% of
     the actual capital injected.

     For such time as tbg holds more than one share in the TC, however, it shall
     receive in addition to the respective minimum-compensation only 9% in
     total for all shares, but not more than a maximum of 7% of the total
     actual deposits.

     This share in profits is payable within two weeks after approval of the
     financial statements by the shareholder ((S)8, Section 2).

3.   The calculations as per Section 2 shall be based on annual profits as per
     the financial statements prepared in accordance with (S) 8, Section 2,
     prior to the consideration of the profit share of tbg according to the
     preceding Section 2.

     a)   The following shall be added to the annual profits:

          -  Taxes paid on profits insofar as they reduce annual profits shown;
          -  If the TC is a partnership, interest debited to the shareholders of
             the TC not taken into account in arriving at the taxable profits of
             the Partnership;
          -  Extraordinary expenditure insofar as it relates to business
             transacted prior to the beginning of the Silent Partnership;
          -  Losses caused by the sale or destruction of property, plant and
             equipment insofar as the latter had already existed at the time of
             the beginning of the Partnership.
<PAGE>

                                                                               7

     b)   The following shall be deducted from the annual profits:

          -  Funds from the release of tax-free reserves set up prior to the
             beginning of the Silent Partnership;

          -  Compensation for services or interest credited to the TC's
             shareholders, insofar as the TC is a partnership, without having
             reduced the taxable profits of the Partnership;

          -  Extraordinary revenues insofar as they relate to business
             transacted prior to the beginning of the Silent Partnership;

          -  Revenues from the sale of property, plant and equipment insofar as
             such goods had already existed at the time of the beginning of the
             Partnership.

     c)   In the year in which the deposit is drawn down, the annual profit for
          the calculation of the profit sharing in accordance with Section 2
          shall be deemed to have occurred evenly throughout the year.

4.   tbg shall be entitled to demand at the end of the lifetime of the
     investment a one-off payment of 30% of the investment, plus an additional
     6% of the amount of the investment for each year after the end of the fifth
     full year of the investment.  The annual profit shares in accordance with
     (S) 9, Section 2, are deducted from the final remuneration due.

     tbg shall exercise this right only in the event that it deems such
     remuneration justified in view of the overall financial situation of the
     TC, especially in view of its profits achieved in the last three years
     prior to the termination of the investment and the hidden reserves
     accumulated during the lifetime of the investment.

5.   tbg shall not share in any losses of the TC.

                                    (S) 10

                                     Taxes

The TC shall be responsible for the payment of the legally prescribed
withholding tax, plus the Solidarity levy, in respect of the remuneration for
the capital provided, and shall withhold from the respective payments to tbg the
withholding tax and the Solidarity levy and shall remit this directly to the
relevant tax office.  Following such remittance, the TC shall furnish tbg with
the respective certificates in accordance with (S) 45a, para. 2 of the Income
Tax Law, using the blank forms provided by tbg.

                                    (S) 11

                     Dissolution of the Silent Partnership

1.   The Silent Partnership shall be dissolved in the event that the TC is
     liquidated.  In this case the capital provided shall be repaid.
<PAGE>

                                                                               8

2.   (S) 9, Section 4 is also applicable in this event.

                                    (S) 12

                                    Notice

1.   The TC is entitled to redeem the shares of tbg entirely or in part at 3
     months' notice as per June 30 or December 31 of each year.  Where such
     redemption is effected before the end of the fifth full year of the
     investment, the capital of tbg shall be paid back with a premium of 30%.
     From the beginning of the sixth year of the investment, (S) 9, Section 4
     shall apply.  tbg may waive payment of the premium if the notice of
     redemption is given for the reason that the promoted innovation project is
     abandoned.

2.   Furthermore, the Silent Partnership may be dissolved with immediate effect
     by either of the Partners with written notice if there is "important
     reason"/1/.  In the event that the deposit is not paid in either fully or
     in part, tbg shall be released from its commitment to deposit with effect
     from the date of such notice.

     tbg has the right to give notice for important reasons, in particular in
     the event that

     a)   the TC made false representations in the Investment Application;

     b)   it becomes evident that the prerequisites upon which the investment
          was undertaken did not exist, or that the prerequisites for continuing
          the investment are no longer fulfilled, in particular if the
          innovation project described in (S) 1, Section 2b, proves non-feasible
          or is abandoned by the TC or is substantially modified. In the event
          that the innovation project described in (S) 1, Section 2, proves to
          be non-feasible in technical or financial terms, tbg may wholly or in
          part waive repayment of the investment if by such waiver the TC can
          continue its operations;

     c)   the TC fails, despite written reminder, to submit the confirmation of
          use in accordance with (S) 3 within three months after such
          confirmation is due;

     d)   any bill of exchange accepted by the TC is disputed, the TC stops
          payments, or it instigates bankruptcy proceedings, or settlement
          proceedings are opened in court, or insolvency is declared in any
          other form;

     e)   the senior specialist or specialists possessing the know-know at the
          TC at the time of the conclusion of the Investment Agreement is/are no
          longer full-time members of the management of the TC;

     f)   one of the measures defined in (S) 5, Section 2 is implemented without
          the prior consent of tbg, and such measure jeopardizes the existence
          of the company or the implementation of the promoted innovation
          project.

_______________________
/1/ This is a special term in the German Civil Code.
<PAGE>

                                                                               9

                                    (S) 13

                                 Payments Due

All payments due shall incur interest at the rate of 4% p.a. from the effective
date of default until the time of receipt by tbg.

                                    (S) 14

                              General Provisions

1.   Amendments or supplements to this Agreement must be in writing.  Any
     supplementary verbal agreements relating to this Agreement shall be
     invalid.

2.   In the event that one provision of this Agreement becomes invalid, this
     shall not affect the validity of any other provision.  The TC and tbg
     undertake to replace invalid provisions by legally valid clauses that
     reflect to the greatest possible extent the sense and purpose of the
     invalid provisions.

3.   Bonn shall be the legal venue for all disputes that may arise from this
     Agreement or its execution.

Bonn, December 14, 1995                           Hamburg, (undated)

Technologie-Beteiligungs-                         SEQUENOM
Gesellschaft mbH der                                    Instruments GmbH
Deutschen Ausgleichsbank

(signed)        (signed)                          (signed: Helmut Schuhsler)

(Signature illegible)
<PAGE>

                                                                              10

tbg                                                     Fax No. +49/228/831 2439

- --------------------------------------------------------------------------------

TC: SEQUENOM Instruments GmbH
    Mendelssohnstr. 15d

    22761 Hamburg

tbg 01023


               Brief Status Report for the Month/2/ of................  199.....

- --------------------------------------------------------------------------------
                                        CURRENT STATUS in '000 DM
- --------------------------------------------------------------------------------
Sales revenues
- --------------------------------------------------------------------------------
Material expense
- --------------------------------------------------------------------------------
Personnel costs
- --------------------------------------------------------------------------------
Preliminary result
- --------------------------------------------------------------------------------

- --------------------------------------------------------------------------------
Orders on the books
- --------------------------------------------------------------------------------
Customer credit facility
whereof utilized
- --------------------------------------------------------------------------------


Matters of particular interest in past month:

Future developments anticipated by Management:

- --------------------------------------------------------------------------------
 . Much better     . better      . the same      . less positive     . much worse
- --------------------------------------------------------------------------------


Place, Date:




                              ________________________________________________
                              (Signature Managing Director and Company Seal)

______________________
/2/ To be submitted by the end of the subsequent month.
<PAGE>

                                                                              11

             ----------------------------------------------------
                             INVESTMENT PRINCIPLES

                                    of

               Technologie-Beteiligungs-Gesellschaft m.b.H.
                        of Deutsche Ausgleichsbank
             ----------------------------------------------------

1.   tbg as Shareholder

     Technologie-Beteiligungs-Gesellschaft m.b.H. (tbg) is a subsidiary of
     Deutsche Ausgleichs- bank.  Within the promotion programme "Investment
     capital for small technology enterprises" supported by the Federal Ministry
     of Education, Science, Research and Technology tbg enters into silent
     partnerships in technology companies (TC) for the financing of innovative
     projects, as a rule without exercising any control in the management of the
     TC.

     The main prerequisite for the involvement is the participation of another
     investor (lead investor) in the TC with a share totalling at least that
     acquired by tbg and management of the tbg investment by the lead investor
     in accordance with a respective cooperation agreement.

2.   Purpose of the Investment

     The participation has the objective of financing innovative projects (cf.
     item 3.1), specifically

     -  for applied research and development up to a logical instant before the
        start-up of commercial production

     -  for investments in market penetration.

3.   Investment Conditions

3.1  Innovation Projects

     -  The innovation project is to promote the use of innovative technologies
        so far not used in the enterprise.
     -  The development shares relating to the innovative core, are provided by
        the enterprise itself. In the event that external services are required
        for the development phase, relevant specifications have to be elaborated
        by the enterprise.
     -  The main features of the new product (process/service) differ in its
        functions from the existing products (processes / services) of the
        enterprise.
     -  The new product (process/service) will create competitive advantages
        (functions, quality, price) and market potential in the relevant market
        (regional, national, European, world) for the enterprise.
<PAGE>

                                                                              12

3.2  Eligible Enterprises

     Enterprises eligible for tbg participation are commercial companies,
     provided they meet the following requirements:

     Small enterprises
     - Place of operation in the Federal Republic of Germany, and
     - Not more than 50 employees, and
     - Either maximum annual turnover of 10 million DM, or a balance sheet total
       of 4 million DM max.

     Medium enterprises
     -  Place of operation in the new federal states and Berlin (East), and
     -  Not more than 250 employees, and
     -  Either maximum annual turnover of 40 million DM, or a balance sheet max.
        total of 20 million DM.

     Economic independence
     A maximum of 25 % of the equity total of the enterprise may be held by
     other companies which do not meet the criteria of small and medium
     enterprises.
     (Exception:  Public investment corporations, venture capital companies, and
                  - provided no control is exercised - institutional investors.)

     Age
     10 years max.

     Technical and commercial know-how

     The TC must have the technical know-how necessary for implementing
     development and production and demonstrate the required business know-how.

     Commercial know-how may also be acquired by involving third parties - e.g.
     the lead investor - if the TC has not achieved any substantial turnover
     until the date of application.

3.3  Cooperating Investor (Lead Investor)

     Lead investors cooperating with tbg may be investment companies as well as
     natural persons and/or legal entities which provide equity for enterprises.

     The lead investor has to acquire shares in the TC equalling at least the
     amount invested by tbg.  He shall advise and assist the TC in all
     commercial and financial matters and, if necessary, also be in a position
     to provide management and marketing assistance.  On principle, he should be
     prepared and able to provide additional financing.

     Prior to the acquisition of an investment, the lead investor shall check
     and document, also on behalf of tbg, the general eligibility of the TC.
     During the lifetime of the investment the lead investor shall supervise the
     management of the TC, monitor the development of the innovation project and
     advise tbg of the TC's financial situation and the innovation
<PAGE>

                                                                              13

     project. Furthermore, he shall be involved in the preparation of the
     confirmation of use (cf. 3.4). Details are stipulator in the cooperation
     agreement between the lead investor and tbg.

3.4  Overall Financing

     Total financing for the innovation project must be secured.  The investment
     funds may be used only for the financing of the innovation project(s) for
     which such investment was granted.  The lead investor is to be advised
     immediately of changes in the innovation project or its funding.

     In the event of a retroactive cost reduction for the innovation project, or
     in the event that further public funds are acquired retroactively for the
     financing of such project so that total funding exceeds 100%, the
     investment may be recalled.  The TC undertakes to document the appropriate
     use of the funds upon completion of the innovation project.  Such
     documentation shall be submitted to tbg via the lead investor and with his
     statement of confirmation.

3.5  Non-Cumulation

     The simultaneous investment by tbg and KfW in an innovation project in the
     scope of this programme is not permitted.

     If the lead investor utilises public funds for his investment, such
     investment shall be subject to the regulations of financial assistance of
     the European Commission.

4.   Conditions of Participation

4.1  Form of Participation

     tbg undertakes investments as silent partner in TC.  No securities are
     required.

4.2  Maximum Investment

     The investment by tbg serves the subsidiary financing of innovation
     projects.  It is limited to DM 3,000,000 per TC.  This maximum amount may
     be used to promote several innovation projects.

4.3  Disbursement

     The investment is generally disbursed in accordance with the progress
     achieved in the innovation project.

4.4  Lifetime

     The lifetime of an investment by tbg is up to 10 full calendar years and
     is, on principle, coupled to the lifetime of the participation by the lead
     investor.
<PAGE>

                                                                              14

4.5  Notice of Termination

     tbg is entitled to recall investments on important grounds.

     The TC may be entitled to recall its investment prematurely with a term of
     notice of 3 months per June 30 and December 31 of each year.  In the event
     of such notice prior to the completion of the 5th year of investment, the
     investment by tbg shall be repayable with a premium of currently 25%, if
     notice is given for reasons other than the termination of the promoted
     innovation project.

4.6  Handling Charge

     Upon disbursement of its investment, tbg shall receive once only from the
     TC a handling fee in the amount of currently 1% of the amount invested.

4.7  Remuneration

     As a rule, tbg demands in compensation for its investment an amount of
     currently 6% p.a. irrespective of the annual results of the TC, and
     remuneration based on the profits of the TC in accordance with the
     financial situation of the TC.  At the end of the investment, tbg may
     demand a once-only remuneration to compensate for the reserves generated by
     the TC during the lifetime of the investment.  Respective details are
     stipulated in the Agreement between tbg and the TC.

4.8  Acceptance of Risk

     The lead investor may be entitled in the cooperation agreement to demand
     from tbg the partial payment of losses incurred from his investment in the
     TC up to five years from the beginning of the participation by tbg in the
     TC.

     In this case tbg will pay the lead investor an amount of up to 50% of the
     total investment of tbg - up to 70% in the new Federal states and Berlin
     (East)-.  tbg may then demand the transfer either in part or wholly of
     the investment of the lead investor to itself or to a third party.  The
     participation in risk is based upon the condition that

     -  the TC is declared bankrupt, or is subject to execution, or proceedings
        have been denied because of deficiency of estate,
     -  an affidavit is filed on behalf of the TC, or
     -  persisting insolvency of the TC is otherwise substantiated,
     -  demands for payment on the part of the lead investor based on his
        investments in the TC have partially been neglected due to court
        proceedings or waiver.

     The remaining risk on the part of the lead investor shall be borne solely
     by the lead investor.

<PAGE>

                                                                   EXHIBIT 10.15

                             COOPERATION AGREEMENT

                      Agreement for a cooperation between


SEQUENOM Inc., Boston, c/o TVM Techno Venture Management L.P., 101 Arch Street
                             Boston, MA 02110, USA

                 - in the following: participation partnership
                       (Beteiligungsgesellschaft: BG) -

       and the Technologie Beteiligungs Gesellschaft mbH of the Deutsche
                     Ausgleichsbank, Wielandstr. 4,53170
                                     Bonn
                            - in the following: tbg

   with the maintenance of the participations mentioned in this agreement in
       SEQUENOM Instruments GmbH, Mendelssohnstrasse 15d, 22761 Hamburg

               - in the following: Technologie-Unternehmen (TU)

                                     (S) 1

                           PARTIES TO THE AGREEMENT

Within the scope of the program "Participation Capital for Start-Up Technology-.
     Companies" carried out by the Bundesministererium fur Bildung,
     Wissenschaft, Forschung und Technologie (BMBF) (Federal Ministry for
     Education, Science, Research and Technology) and the Deutsche
     Ausgleichsbank, tbg supports small technology-companies of the industrial
     economy, as long as they are not older than 10 years and as long as they
     comply with the definition of small and middle size firms (KMU) in the new
     federal states and Berlin (East), and small firms in the remaining federal
     area, respectively; i.e.

- -  they do not employ more than 250 (50) workmen and either
- -  achieve an annual turnover of not more than 40 Mio. DM (10 Mio. DM) or
- -  achieve a balance sheet total of not more than 20 mio DM (4 mio DM), and
- -  are in possession of at the most 25% of one or more of companies not
   fulfilling these definitions (exception: public participation companies, high
   risk capital companies and - as far as no control is exercised -institutional
   investors).

All three prerequisites have to be fulfilled simultaneously; i.e. a company is
only considered as KMU, if it has the required independence, if it meets the
given with regard to the number of employees, and if it does not excede at least
one of the limiting values for the annual turnover or balance sheet total
respectively.
<PAGE>

tbg takes over shares for the financing of innovation projects according to the
participation principles added by tbg, which are part of this agreement and
which BG recognizes and that:

- -  for applied research and development up to a logic second before the
   beginning of the commercial production according to the EU definition with
   the following limitations:

- -  Applied research encompasses research or experiments with the purpose, to
   obtain new knowledge in order to facilitate the creation of new products,
   methods of production, or services. Normally we can say that it ends with the
   creation of a first prototype. Development encompasses work on the basis of
   applied research with the objective of the introduction of new or essentially
   improved products, methods of production or services up to - but not
   including - the industrial application and the commercial use. To this level
   belong pilot projects and demonstration projects, as well as the further
   necessary development work that will finally flow into a bundle of
   information which permits the taking up of the production.

- -  for the investments for the introduction to the market

tbg intends to take over a silent participation in the amount of DM
3,000,000.00, provided that it will undertake that the participation mentioned
in section 2 between BG and TU will be agreed to. A copy of the intended
participation agreement between tbg and TU is attached to this agreement.

2) BG intends to take over from TU a participation in form of a non-refundable
   (company) premium in the amount of DM 3,000,000.00. This premium stands in
   relation with a pre-existing ordinary capital of BG in TU in the amount of DM
   37,500.00

BG confirms that it will not lay any claims on the refinancing of a
participation in TU in the scope of the program "participation capital for small
technology companies" and the promotion (refinancing or securing) of this
participation in TU from the ERP special assets.

3) The parties will immediately inform each other in writing, if the mentioned
   participation arrangements have been finalized with TU. As far as the final
   participation agreements differ from the announced drafts, the agreements
   have to be transmitted in the authoritative version and deviations
   (differences) are to be explained on request.

4) Possible later amendments of the participation agreements, sale/mortgaging of
   the shares and of the claims to tbg resulting from this cooperation
   agreement, or further participation or loan agreements, the parties shall
   only agree with the consent of their party to the agreement. As far as a
   proper notice to terminate between BG and TU is admissible through BG, it
   also needs the approval of tbg. The partners have to inform each other
   immediately about a notice of termination due to important reason, if
   possible before the announcement of the notice of termination.

                                     (S) 2

                               MANAGEMENT OF TU

                                       2
<PAGE>

BG will control with the necessary care the management of TU and the development
of the innovation scheme promoted by tbg and assist TU, if required, with
management support.  Fundamentally, BG is willing and in a position, but not
obliged, to make additional means of financing available to TU, if needed.

                                     (S) 3

                               USE OF RESOURCES

Before the call off of means of participations of tbg, BG will verify the agreed
upon call off assumptions between tbg and TU and, as far as they exist, confirm
them. BG will support the call off, if there are neither economical nor
Technical objections regarding the realization of the innovation plan promoted
by tbg at the time of the call off and after their knowledge.

2) BG will verify and confirm the use according to paragraph 3 of the
   participation agreement between tbg and TU.

                                     (S) 4


                        INFORMATION AND CONTROL RIGHTS

1) BG obliges itself with tbg to the reporting about the economic situation of
   TU and about the position of the innovation plan promoted by tbg.

2) Reports are to be made regularly half-yearly up to March 31 and up to
   September 30.

3) An immediate and if possible a preceding report of tbg has to result by means
   of all measures known to BG that excede the normal management of TU. These
   are in particular the measures in need of consent, that according to (S) 5 of
   the participation agreement between tbg and TU and the reasons mentioned in
   (S) 12 of this participation agreement for a termination due to an urgent
   reason.

4) The report shall be made in writing, and in urgent cases mainly orally,
   provided that tbg does not renounce this explicitly in writing.

5) tbg is entitled to request on its own or through a designated third party
   extensive information about all legal relations of BG with TU and to inspect
   at BG all documents regarding TU.

6) BG agrees that tbg conveys to BMBF or the EU commission, on request, the
   existing data regarding his participation in TU for the realization of
   supervision and control authorities.

7) BG furthermore agrees that tbg conveys the obtained data about the
   participation of BG in TU for the scientific evaluation of the pilot project
   (Modellversuch) mentioned in (S) 1, section 1 of this agreement, to BMBF or
   to an appointed institution. Moreover, BG agrees to

                                       3
<PAGE>

   provide immediately the information, required for the scientific evaluation
   of the pilot project, to BMBF and to an appointed institution. With regard to
   the evaluation and if need be with regard to the publication of data about
   the pilot project, it will be secured (guaranteed) that BG will suffer no
   damages.

                                     (S) 5

                              Risk participation

Investment refers to BG's total payment made for the subscription of the shares
- ----------
in TU.  This includes registered capital and share premium.

BG refers to Sequenom Inc.
- --
tbg refers to the entity providing the silent partnership.
- ---
TU refers to Sequenom Instruments GmbH
- --

BG is entitled to a partial compensation of a loss of its Investment entered
into with TU according to (S) 1 section 2 (registered capital and premium)
within 5 years from the beginning of the participation of tbg with TU.

1) A claim to a compensation from tbg is justified, if a bankruptcy procedure
has been opened or has been initiated or if the opening of bankruptcy
proceedings has been denied due to a lack of assets, or if an affidavit has been
issued on behalf of the TU, or the continuous insolvency of TU has been proven
in a different way.

tbg will pay to BG within 30 calendar days after the day of its justified claim
a sum of 50% of its Investment made for acquiring the participation (i.e., which
has been matched by the silent partnership) according to (S) 1 section 2, at the
most, however, 50% of its own amount of participation paid to TU.  The upper
limit of tbg's payment will be adjusted to reflect a prior reduction of the
silent partnership participation of tbg, such reduction being possible according
to the Silent Partnership Agreement between tbg and TU.

2) If, due to a settlement by court (or outside court) of any claims of BG
   resulting from its participation a certain proportion of its Investment
   according to (S) 1 section 2 has been lost, or if BG within the scope of
   measures of stabilization, in which all creditors and participation donors of
   TU- the latter being equal quotas - are participating, has partially waived a
   claim to its Investment as defined in (S) 1 section 2, then BG can claim from
   tbg the reimbursement of this partial loss. However, tbg will only pay an
   amount that is in the same proportion with the highest amount of the risk
   participation (see section 1), as the partial loss of BG is to the total
   amount of its Investment. A partial payment reduces further obligations of
   tbg under the risk participation. (In other words, if the actual loss of the
   BG is reduced by a bankruptcy settlement or other settlement, then the claim
   to the tbg will be reduced in the same fashion.)

3) Until the termination of the sixth calendar month following BG's claim, tbg
   can demand from BG the total or partial transfer of the stock mentioned in
   (S) 1 section 2 to itself or to a third party appointed by tbg. Contingent
   payment obligations into TU's registered capital or share premium account,
   and damages obligations of BG will not be transferred to tbg. Transfer cost
   will be borne by BG. With the partial claim of tbg according to 2) the
   transfer obligation of BG is reduced in the same proportion as the payment
   obligation of tbg. (This

                                       4
<PAGE>

   provision allows the tbg to have up to six months to decide to whom it may
   transfer the stock of the TU.) The transferability of TU's stock has to be
   maintained by BG and is a prerequisite for claiming tbg's risk participation.

                                     (S) 6

                   BEGINNING AND DURATION OF THE COOPERATION

1) BG is obliged towards tbg with the care of TU according to (S) 2 and with the
   informing according to (S) 4 of this agreement from the time when this
   agreement and the participation agreements between tbg and TU, as well as BG
   and TU have been signed by the participants respectively.

2) The cooperation ends with the termination of the participation of tbg or BG.

3) The proper termination of this cooperation agreement is excluded.

                                     (S) 7

                              GENERAL PROVISIONS

1) Amendments and supplements of this agreement are needed in writing.  Oral
   agreements on the side of this agreement do not exist.

2) If one provision of this agreement is legally ineffective, then the other
   provisions are not affected by it. BG and tbg are obliged to replace
   ineffective provisions of agreement by regulations that are legally effective
   and that are corresponding in idea and purpose to the legally ineffective
   provisions as far as possible.

3) Bonn has been agreed upon as legal domicile for all legal disputes resulting
   from this agreement and its realization.

Bonn,                                          Boston

Technologie-Beteiligungs-                      SEQUENOM Inc., Boston
Gesellschaft m. b. H. der                      c/o TVM Techno Venture Management
Deutschen Ausgleichsbank                       101 Arch Street
                                               Boston, MA 02110
                                               USA

                                       5

<PAGE>

                                                                   EXHIBIT 10.16

                              INVESTMENT CONTRACT


        Agreement concerning the Establishment of a Silent Partnership
                                    between
         SEQUENOM Instruments GmbH, Mendelssohnstr. 15D, 22761 Hamburg
           - hereinafter referred to as : Technology Company ("TC")
                                      and
                  Technologie-Beteiligung-Gesellschaft m.b.H.
             of Deutsche Ausgleichsbank, Wielandstr. 4, 53170 Bonn
                     - Silent Partner (hereinafter: tbg) -

                               in the amount of

                                DM 2,000,000.-

       for the Financing of the Project described in (S) 1, Section. 2.


                                   Preamble

Within the scope of the DtA-Technology Programme, tbg undertakes investments for
the financing of projects in the early phase, of innovative projects and of
exit-financing projects according to the investment principles of this programme
which are an integral part of this--Agreement.

                                     (S) 1

                         Objectives of the Partnership

1.  According to the Articles of Incorporation in their valid version dated Nov.
    10, 1994, the TC, which is registered under No. B 57315 in the Company Roll
    of the District Court of Hamburg, operates a commercial enterprise for the
    purposes of:

    Development, production and marketing of devices for the sequencing of DNA,
    sale of sequencing information, and development of medical diagnostics and
    therapeutics.

2.  Within the scope of this business objective, the TU is engaged in:

    Automation of the newly developed technology process and proprietary chip
    development.

                                     (S) 2

                               Capital Injection

1.  For the exclusive use of financing the innovative project described and
    based upon the information provided by the TC in the Application for
    Investment dated June 16/17, 1997 tbg

<PAGE>

    makes an investment in the amount of DM 2,000,000.--, provided that the TC
    documents the following investment agreements:

    Investment in the amount of DM 2,000,000.- by Sequenom Inc., II 555 Sorrento
    Valley Road, San Diego, CA 9212 1, USA (hereinafter referred to as AC, also
    in the case of multiple investors), and provided that the AC has concluded a
    co-operation agreement with tbg.

    The AC will consult with TVM Techno Venture Management, Denninger Str. 15,
    81679 Munich - hereinafter referred to as TVM -- regarding management of the
    TU.

    Authorisation of tbg to draw down the fixed payments due tbg.

2.  The injection by tbg shall be used for the co-financing of the project-
    related planning described in Annex I which is an integral part of this
    investment contract.

3.  The TC is entitled to draw down the capital after the company becomes
    operational (cf. (S)3, Section 1), provided that its immediate designated
    utilisation and a proportional use of funds together with the other means of
    financing foreseen in Annex I and total financing of the innovation project
    are guaranteed.

    The withdrawal must have appended a confirmation by the AC and TVM that the
    prerequisites for the withdrawal have been met.

4.  This Agreement shall expire in the event that the capital is not drawn down,
    at least in part, latest by March 31, 1998.

5.  tbg is entitled to withhold a processing fee in the amount of 1% of the
    total injection specified in this Agreement. Such fee will be withheld from
    the first partial withdrawal.

6.  The TC shall establish a separate deposit account for the injection by tbg.
    Withdrawals from this account by tbg are precluded.


                                     (S) 3

                   Beginning and Lifetime of the Partnership

1.  The Silent Partnership shall commence as soon as both parties have signed
    this Contract.

2.  The Silent Partnership shall terminate on Dec. 31, 2007.

3.  tbg's capital and any outstanding profit shares shall be due for payment to
    tbg upon termination of the Partnership.

4.  In the event that the funds invested by the AC are repaid before Dec. 1,
    2005, the investment made by tbg shall be repayable at the same time and to
    the same extent. tbg is entitled to request a final remuneration with
    reference to the part of its capital due for early repayment in accordance
    with the respective enforcement of $8 Section 4.

                                       2
<PAGE>

                                     (S) 4

                                  Management

1.  tbg shall have no control in the management of the TC insofar as not
    stipulated otherwise in the following.

2.  The TC shall obtain the approval of tbg in respect of.

    (a) any amendment to the Articles of Incorporation, in particular any
        modification of the purpose of the company, acceptance of new
        shareholders, or agreement of new investments;

    (b) the appointment and dismissal of executive managers of the TC;

    (c) the conclusion, amendment and termination of contracts governing the
        granting or acquisition of licences, patents, prototypes, samples,
        trademarks or know-how insofar as they relate to the innovation project
        promoted by tbg;

    (d) the conclusion, amendment and termination of major sales contracts;

    (e) the partial or entire relocation, leasing, sale or closing down of the
        operation;

    (f) the conclusion and termination of control and profit pooling contracts.

    (g) the abandonment or substantial modification of the innovation project
        described in (S) 1 Section

    (h) the entry into commitments insofar as these are not covered by the
        project financing by tbg, for investments exceeding the amount of DM
        100,000, or for leasing, rental or leasehold agreements involving
        monthly payments of more than DM 10,000.

3.  Approval in accordance with (S) 4, Section 2, shall be obtained directly
    from tbg.

    Insofar as tbg fails to give written notice of its refusal of approval
    within a period of 14 days after receipt of the notification advising it of
    the measure requiring approval, such approval shall be deemed as given.

                                     (S) 5

                             Reporting and Control

1.  The TC shall report to tbg semi-annually, by March 31 and September 30 of
    each year, respectively, the financial situation of the TC and the status of
    the innovation project described in (S) 1, Section 2 until such time when
    tbg, waives such reports, because the AC exercises control of the TC also on
    behalf of tbg. In addition, the TC shall file with tbg brief

                                       3
<PAGE>

    monthly status reports in the form appended hereto in Annex II, and at the
    end of the financial year a respectively updated business plan for the year
    following.

2.  Regardless whether the AC exercises control in the TC also on behalf of tbg,
    the TC shall notify tbg directly immediately of all measures exceeding the
    scope of normal business transactions.

3.  Furthermore, tbg is entitled to exercise its rights of control in accordance
    with (S) 716 of the German Civil Code. This shall apply also after
    termination of the Partnership to the extent required for the verification
    of the funds to be distributed.

    tbg is further entitled the review all the documentation of the TC
    pertaining to the innovation project described in (S) 1, Section 2b. To
    exercise its rights of control, tbg is entitled to avail itself of the
    services of third parties.

5.     According to (S) 91 of the Federal Budget Regulations (BHO), the TC is
       subject to audit by the Auditor General's Department. The TC shall
       furnish the Auditor General's Department and tbg with all documentation
       deemed necessary by the Department of the Auditor General for the purpose
       of audit.

                                     (S) 6

                                Advisory Board

tbg may at any time request the establishment of an advisory board.
tbg shall participate in this board to an extent commensurate with the amount of
its capital.

The advisory board shall advise the TC concerning commercial and technical
issues, in particular with regard to the project described in (S) 1, Section 2b.
The board shall be entitled to the same rights to information and control as
they are granted to tbg under this Agreement.

                                     (S) 7

                        Financial Year, Annual Accounts

1.  The financial year of the Silent Partnership concurs with the financial year
    of the TC ("investment Year"). The financial year of the TC shall end on
    31 December of each year.

2.  The TC shall prepare its annual financial statements (balance sheet, profit
    and loss account, notes) in accordance with (S)(S) 238-289 of the Code of
    Commercial Law within six months after the end of the financial year and
    shall submit one signed original specimen together with the confirmation of
    a certified public accountant or auditor.

                                       4
<PAGE>

                                     (S) 8

                            Profit and Loss Sharing

1.  tbg shall receive on its capital, irrespective of the TC's annual earnings,
    a minimum return of 7% p.a. This shall be payable retroactively every six
    months, on May 31 and November 30 of each year.

2.  Furthermore, tbg shall receive 9% of all annual profits achieved from the
    date of draw-down of the investment.

    For such period where tbg holds more than one investment in the TU, however,
    tbg shall receive only 9% in total of annual profits achieved for all
    investments in addition to the respective minimum payments, up to a maximum
    of 7% p.a. of the sum of all investments in total.

    In the event that additional capital is injected in the TC within the scope
    of additional rounds of financing, tbg shall adjust its share in profits to
    the effective capital situation at the time.

    Such share in profits shall be payable within two weeks after finalisation
    of the annual financial statement ((S) 8 Section 2).

3.  The calculations as per Section 2 shall be based on annual profits prior to
    the consideration of the profit share of tbg according to the preceding
    Section 2.

    a) The following shall be added to the annual profits:

       - taxes paid on profits as well as possible managers' shares, insofar as
         they reduced annual profits shown;

       - Extraordinary expenditure insofar as it is incurred from business
         transacted prior to the beginning of the Silent Partnership;

       - Losses caused by the sale or destruction of company assets insofar as
         the latter had already existed at the time of the beginning of the
         Partnership.

    b) The following shall be deducted from the annual profits:

       - Funds from the release of tax-free reserves set up prior to the
         beginning of the Silent Partnership;

       - Compensation for services or interest credited to the TC's
         shareholders, insofar as the TC is a partnership, without having
         reduced the taxable profits of the Partnership;

       - Extraordinary revenues insofar as they relate to business transacted
         prior to the beginning of the Silent Partnership;

                                       5
<PAGE>

       - Grants, allowances and subsidies from public agencies insofar as these
         contributed to profits;

       - Revenues from the sale of property, plant and equipment insofar as such
         goods had already existed at the time of the beginning of the
         Partnership.

    c) In the year in which the deposit is drawn down, the annual profit for the
       calculation of the profit sharing in accordance with Section 2 shall be
       deemed to have occurred evenly throughout the year.

4.  tbg shall be entitled to demand at the end of the lifetime of the investment
    a one-off remuneration of 35% of the total of the investment, plus an
    additional 7% of the investment for each year after the end of the fifth
    full year of the Partnership. Shares of profits paid annually in accordance
    with (S) 8 Section 2 shall be set off against the final remuneration. Should
    the sum of the profit shares exceed such final remuneration, no respective
    payment shall be made.

    tbg shall exercise this right only in the event that it deems such
    remuneration justified in view of the overall financial situation of the TC,
    especially in view of its profits achieved in the last three years prior to
    the termination of the investment and the hidden reserves accumulated during
    the lifetime of the investment.

5.  tbg shall not share in any losses of the TC.

                                     (S) 9

                                     Taxes

The TC shall be responsible for the payment of the legally prescribed
withholding tax, plus the Solidarity levy, in respect of the remuneration for
the capital provided, and shall withhold from the respective payments to tbg the
withholding tax and the Solidarity levy and shall remit this directly to the
relevant tax office. Following such remittance, the TC shall furnish tbg within
two months of the due date of payments with the respective certificates in
accordance with (S) 45a, Section 2 of the Income Tax Law, using the blank forms
provided by tbg.

                                     (S) 10

                     Dissolution of the Silent Partnership

1.  The Silent Partnership shall be dissolved in the event that the TC is
    liquidated. In that event the relevant investment shall be repaid.

2.  (S) 3, Section 3 and (S) -8, Section 4 shall be applicable also in this
    event.

                                       6
<PAGE>

                                    (S) 11

                                    Notice

1.  The TC is entitled to redeem the shares of tbg entirely or in part at 3
    months' notice as per June 30 or December 31 of each year. Where such
    redemption is effected before the end of the fifth full year of the
    investment, the capital of tbg shall be paid back with a premium of 25%.
    From the beginning of the sixth year of the investment, (S) 8, Section 4
    shall apply. tbg may waive payment of the premium if the notice of
    redemption is given for the reason that the promoted innovation project is
    abandoned.

2.  Furthermore, the Silent Partnership may be dissolved for important reason
    with immediate effect by either of the Partners with written notice. In the
    event that the capital has not yet been paid in either fully or in part, tbg
    shall be released from its commitment to make an injection with effect from
    the date of such notice.

    tbg has the right to give notice for important reasons, in particular in the
    event that

    a) the TC made false representations in the Investment Application;

    b) it becomes evident that the prerequisites upon which the investment was
       undertaken did not exist, or that the prerequisites for continuing the
       investment have are no longer fulfilled, in particular if the innovation
       project described in (S) 1, Section 2b, proves non-feasible or is
       abandoned by the TC or is substantially modified. In the event that the
       innovation project described in (S) 1, Section 2, proves to be non-
       feasible in technical or financial terms, tbg may waive repayment of the
       investment wholly or in part if by such waiver the TC can continue its
       operations;

    c) any bill of exchange accepted by the TC is disputed, the TC stops
       payments, or the TC instigates bankruptcy proceedings, or settlement
       proceedings are opened in court, or insolvency is declared in any other
       form;

    d) the senior specialist or specialists possessing the know-know at the time
       of the conclusion of the Investment Agreement is/are no longer full-time
       members of the management of the TC;

    e) one of the measures defined in (S) 4, Section 2 is implemented without
       the prior consent of tbg.

                                    (S) 12

                                 Payments Due

All payments due shall incur interest at the rate of 4% p.a. from the effective
date of default until the time of receipt by tbg.

                                       7
<PAGE>

                                    (S) 13

                              General Provisions

1.  Amendments or supplements to this Agreement must be in writing. Any
    supplementary verbal agreements relating to this Agreement shall be invalid.

2.  In the event that one provision of this Agreement becomes invalid, this
    shall not affect the validity of any other provision. The TC and tbg
    undertake to replace invalidated provisions by legally valid clauses that
    reflect to the greatest possible extent the sense and purpose of the invalid
    provisions.

3.  Bonn shall be the legal venue for all disputes that may arise from this
    Agreement or its execution.

Bonn, October 7, 1997              Hamburg, September 22, 1997
Technologie-Beteiligungs-                    SEQUENOM
Gesellschaft mbH der               Instruments GmbH
Deutschen Ausgleichsbank

(signed)             (signed)            (signed: Dr. T. Schuh)

(Signatures illegible)

                                       8
<PAGE>

                                                      Project Schedule (Annex 1)
                                                  Brief Status Report (Annex 11)
                                                 Principles of Investment of tbg

                                       9
<PAGE>

<TABLE>
<CAPTION>
                          COST AND FINANCING SCHEDULE

                      for the Period 09/01/97 - 12/31/99

- ---------------------------------------------------------------------------------------------------------------------
Project-related Expenditure                                                         Amount in DM (exc. VAT)
- ---------------------------------------------------------------------------------------------------------------------
<S>                                                                                 <C>
I        For applied research and development
- ---------------------------------------------------------------------------------------------------------------------
1.       Investments reported as tangible assets
- ---------------------------------------------------------------------------------------------------------------------
1.1      Laboratory equipment and plant                                                                    1,087,000
- ---------------------------------------------------------------------------------------------------------------------
1.2      Machinery and plant for the production of prototypes
- ---------------------------------------------------------------------------------------------------------------------
1.3      Miscellaneous
- ---------------------------------------------------------------------------------------------------------------------
2.       Non-investment research and development expenditure
- ---------------------------------------------------------------------------------------------------------------------
2.1      Personnel                                                                                         1,352,000
- ---------------------------------------------------------------------------------------------------------------------
2.2      Materials                                                                                           456,000
- ---------------------------------------------------------------------------------------------------------------------
2.3      Outside services (contracts/consulting)                                                           1,160,000
- ---------------------------------------------------------------------------------------------------------------------
2.4      Patents and registrations
- ---------------------------------------------------------------------------------------------------------------------
2.5      Travel expenditure
- ---------------------------------------------------------------------------------------------------------------------
2.6      Miscellaneous
- ---------------------------------------------------------------------------------------------------------------------
II       Investments for Market Entry
- ---------------------------------------------------------------------------------------------------------------------
TOTAL                                                                                                      4,055,000
- ---------------------------------------------------------------------------------------------------------------------


<CAPTION>
- ---------------------------------------------------------------------------------------------------------------------
Project-related Financing                                   Amount in DM (exc. VAT)
- ----------------------------------------------------------------------------------------------------------------------
</TABLE>

1.       Own funds

                                       10

<PAGE>

                                     [LOGO]                        EXHIBIT 10.21
                                    SEQUENOM

                              BETA TEST AGREEMENT

This Agreement, dated March 1, 1999, is made by and between SEQUENOM, Inc., a
corporation with its principal place of business located at 11555 Sorrento
Valley Rd, San Diego, CA, USA, ("Company"), represented by SEQUENOM GmbH, and
GLE Medicon GmbH, with its principal place of business at LornsenstraBe 4-6,
22767 Hamburg, Federal Republic of Germany, ("Recipient").

     WHEREAS, Company is willing to supply within the protection of a
confidential relationship, the DNA MassArray(TM) Basic System Plus and related
materials listed on Schedule A attached hereto ("Evaluation Item") to Recipient
solely for evaluating whether to enter in the currently proposed business
arrangement with Company ("Evaluation");

     WHEREAS, Recipient desires to have access to the Evaluation Item and is
aware of the nature of the Evaluation Item, and is willing to enter in a
confidential relationship and to use and test the Evaluation Item and report to
Company on the performance of the Evaluation Item;

     NOW, THEREFORE, in consideration of the foregoing and the mutual covenants
hereinafter set forth, the parties hereby agree as follows:


     1.   Use of DNA MassArray(TM) Basic System and SpectroChip(TM) License.
          -----------------------------------------------------------------
Subject to the terms of this Agreement Company grants to Recipient       ***
***                          ***  The Company shall at all times retain all
title to and ownership of the Evaluation Item and all ancillary products
thereof. Recipient agrees to use the Evaluation Item only in the ordinary course
of testing and comparing it's performance against comparable technologies in the
Recipient's facility, and Recipient will not reproduce or modify the Evaluation
Item or any portion thereof. Recipient shall not rent, sell, lease or otherwise
transfer the Evaluation Item or any part thereof or use it for the benefit of a
third party. Recipient shall not reverse assemble, reverse compile or reverse
engineer the Evaluation Item, or otherwise attempt to discover any Evaluation
Item underlying Proprietary Information (as that term is defined below).

     2.   Business Terms. All payments herein are for the use of Company's
          --------------
Evaluation Item and the services required for the operation of the Evaluation
Item including training and support.

i.                                     ***
            ***   After the completion of the initial    ***  Beta-test period
the Evaluation Item cost will be       ***

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

ii.     ***    fee during the Beta-site period for all tests performed for
     comparison of Evaluation Item with other DNA analysis methods and with
     results of comparison tests reported to SEQUENOM.

iii. Annual Maintenance Fee that includes Evaluation Item support and Company
     Bioinformatics Workstation updates                 ***
          ***  The incremental Maintenance Fee will be         ***      upon
     delivery of all data necessary to complete each bi-monthly report as
     specified under 4.
                                      ***
                                      ***
                                      ***    All Maintenance Fees paid during
     the initial *** Beta-test period will be credited towards the Equipment.

iv.  One Company senior scientist designated for on-site support during the
     Beta-test period to facilitate the technology transfer and SYSTEM start-up.
     Recipient shall provide the Company scientist full access to the Contracted
     Item at the Recipient's facility during regular business hours.

v.   Agreement is contingent on the use of authorized consumables provided from
     Company.

     3.   Confidentiality; Ownership. Recipient acknowledges that, in the course
          --------------------------
of using the Evaluation Item and performing its duties under this Agreement, it
may obtain information relating to the Evaluation Item and/or Company
("Proprietary Information"). Such Proprietary Information shall belong solely to
Company and includes, but, is not limited to, the existence of the Evaluation
Item, its features and mode of operation, this Agreement, trade secrets, know-
how, inventions (whether or not patentable), techniques, processes, programs,
ideas, algorithms, schematics, testing procedures, software design and
architecture, computer code, internal documentation, design and function
specifications, product requirements, problem reports, analysis and performance
information, software documents, and other technical, business, product,
marketing and financial information, plans and data. In regard to this
Proprietary Information:

     (a) Recipient shall not during the term of this Agreement and for a period
     of at least three (3) years after its termination, use (except as expressly
     authorized by this Agreement) or disclose Proprietary Information without
     the prior written consent of Company unless such Proprietary Information
     becomes part of the public domain without breach of this Agreement by
     Recipient, its officers, directors, employees or agents.

     (b) During the period specified in (a) above, Recipient agrees to take all
     reasonable measures to maintain the Proprietary Information and Evaluation
     Item in confidence.

     (c) During the period specified in (a) above, Recipient will disclose the
     Evaluation Item and Proprietary Information only to those of its employees
     and consultants as are necessary for the use expressly and unambiguously
     licensed hereunder, and only after such employees and contractors have
     agreed in writing to be bound by the provisions of this Agreement.
     Recipient shall not, without the prior written consent of Company,


     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                    Page 2
<PAGE>

     disclose or otherwise make available the Evaluation Item or any ancillary
     products to any third party.

     (d) Recipient hereby assigns to Company any invention, idea or know-how
     (whether or not patentable) that is conceived, learned or reduced to
     practice in the course of performance under this Agreement and any patent
     rights, trade secret rights, mask work rights, sui generis database rights
     and all other intellectual and industrial property rights of any sort with
     respect thereto. Recipient agrees to take any action reasonably requested
     by Company to evidence, perfect, obtain, maintain, enforce or defend the
     foregoing.

     4.   Reports.
          -------

     Company senior scientist, assisted by Recipient, shall provide written
     reports bi-monthly commencing after installation of the Evaluation Item.
     Reports shall disclose:

                                      ***
                                      ***
                                      ***
                                      ***

     5.   WARRANTY DISCLAIMER.
          -------------------

The parties acknowledge that the Evaluation Item is for use in a Beta test.
COMPANY DISCLAIMS ALL WARRANTIES RELATING TO THE EVALUATION ITEM, EXPRESS OR
IMPLIED, INCLUDING, BUT NOT LIMITED TO, ANY WARRANTIES AGAINST INFRINGEMENT OF
THIRD-PARTY RIGHTS, MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE.

     6.   Limitation of Remedies and Damages.
          ----------------------------------

COMPANY SHALL NOT BE RESPONSIBLE OR LIABLE WITH RESPECT TO ANY SUBJECT MATTER OF
THIS AGREEMENT UNDER ANY CONTRACT, NEGLIGENCE, STRICT LIABILITY OR OTHER THEORY
(A) FOR LOSS OR INACCURACY OF DATA OR COST OF PROCUREMENT OF SUBSTITUTE GOODS,
SERVICES OR TECHNOLOGY, OR (B) FOR ANY INDIRECT, INCIDENTAL OR CONSEQUENTIAL
DAMAGES INCLUDING, BUT NOT LIMITED TO LOSS OF REVENUES AND LOSS OF PROFITS.
COMPANY SHALL NOT BE RESPONSIBLE FOR ANY MATTER BEYOND ITS REASONABLE CONTROL.

     7.   Nonassignability. Neither the rights nor the obligations arising under
          ----------------
this Agreement are assignable or transferable by Recipient, and any such
attempted assignment or transfer shall be void and without effect.

     8.   Execution of Agreement, Controlling Law, Attorneys' Fees and
          ------------------------------------------------------------
Severability. This Agreement shall become effective only upon its execution by
- ------------
both Company and Recipient and it

     ***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                    Page 3
<PAGE>

shall be governed by and construed in accordance with the laws of the Federal
Republic of Germany without regard to the conflicts of laws provisions therein.
In any action to enforce this Agreement the prevailing party will be entitled to
costs and attorneys' fees. In the event that any of the provisions of this
Agreement shall be held by a court or other tribunal of competent jurisdiction
to be unenforceable, such provisions shall be limited or eliminated to the
minimum extent necessary so that this Agreement shall otherwise remain in full
force and effect and enforceable.

     9.   Entire Agreement. This Agreement constitutes the entire agreement
          ----------------
between the parties pertaining to the subject matter hereof, and any and all
written or oral agreements previously existing between the parties are expressly
cancelled. Any modifications of this Agreement must be in writing and signed by
both parties.

     10.  Equitable Relief. Recipient acknowledges and agrees that due to the
          ----------------
unique nature of Company's Proprietary Information, there can be no adequate
remedy at law for any breach of its obligations hereunder, that any such breach
may allow Recipient or third parties to unfairly compete with Company resulting
in irreparable harm to Company, and therefore, that upon any such breach or
threat thereof, Company shall be entitled to injunctions and other appropriate
equitable relief in addition to whatever remedies it may have at law.

     11.  Termination. This Agreement may be terminated (1) by Company without
          -----------
cause with twenty-one (21) days' written notice to the Recipient at the address
listed above, (2) by Recipient if the first bi-monthly report should reveal
uncompetitive performance in accuracy of the system compared to existing
technologies after the first two months and the Recipient wishes to terminate
this Agreement as a consequence of this, or (3) immediately upon notice of any
breach by Recipient of the provisions of this Agreement, and (4) in any case
will terminate six (6) months after the initiation of the first reportable test
at the Recipient's facility. Company and Recipient will enter into good faith
discussions sixty (60) days prior to the termination of the Beta Site Agreement
to negotiate a full DNA MassArray(TM) license Agreement. If no full license
Agreement has been established upon termination, the license granted hereunder
shall terminate and Recipient shall immediately return the Evaluation Item,
together with any and all documents, notes and other materials regarding the
Evaluation Item to Company, including, without limitation, all Proprietary
Information and all copies and extracts of the foregoing, but the terms of this
Agreement will otherwise remain in effect.

     12.  PUBLIC ANNOUNCEMENTS. Any announcements or similar publicity with
respect tthe execution of this Agreement shall be agreed upon between the
Parties in advance of such announcement, with such approval not unreasonable
withheld. Both Parties understand that this Agreement is likely to be of
interest to investors, analysts and others, and that the Parties therefore may
make such public announcements with respect thereto. The Parties agree that any
such announcement will not contain confidential business or technical
information and, if disclosure of confidential business or technical information
is required by law or regulation, will make reasonable efforts to minimize such
disclosure and obtain confidential treatment for any such information which is
disclosed to a governmental agency or group. Each Party agrees to



                                    Page 4
<PAGE>

provide to the other Parties a copy of any public announcement as soon as
reasonably practicable under the circumstances prior to its scheduled release.
Except under extraordinary circumstances, each Party shall provide the other
with an advance copy of any press release at least five (5) business days prior
to the scheduled disclosure. Each Party shall have the right to expeditiously
review and recommend changes to any announcement regarding this Agreement or the
subject matter of this Agreement. Except as otherwise required by law, the Party
whose press release has been reviewed shall remove any information the reviewing
Party reasonably deems to be inappropriate for disclosure.


SEQUENOM, GmbH.                       GLE Medicon GmbH & Co

By   /s/ - Dr. Warsten Schmidt        By   /s/ Oliver Gotz
     -------------------------             ---------------

Name (Print) Dr. Warsten Schmidt      Name (Print): Dr. Oliver Gotz
             -------------------                    ---------------
Title: Managing Director              Title: Managing Director
       -----------------                     -----------------

Confidential
                                    Page 5
<PAGE>

                                  Schedule A


DNA MassArray(TM) Basic System Plus Evaluation Items include:

     .    High-speed Bruker/SEQUENOM Array Mass Spectrometer
     .    GeSIM/SEQUENOM Monocharnel Nanoplotter
     .    SEQUENOM BioMASS Informatics Workstation
     .    Beckman Multimek(TM) Instrument with SEQUENOM magnetic lifters

vi.  The SEQUENOM 96 D SpectroChip(TM) will be made available *** during the
     Beta test period for all tests that are performed for comparison of DNA
     MassArray(TM) performance with other DNA analysis methods with result
     reported to SEQUENOM. For all samples being analyzed using DNA
     MassArray(TM) for routine laboratory testing (without a performance report
     to SEQUENOM) a price of *** . An "Element" represents ***
                                                           ***
                                                           ***

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

Confidential

                                    Page 6

<PAGE>

SEQUENOM BETA TEST AGREEMENT        [LOGO]                                   1/6

                                                                   EXHIBIT 10.22
                              BETA TEST AGREEMENT

This Agreement, dated April ...., 1999, is made by and between SEQUENOM, Inc., a
corporation with its principal place of business located at 11555 Sorrento
Valley Rd, San Diego, CA, USA, ("Company"), represented by SEQUENOM GmbH, and
Priv.-Doz. Dr. med. Harald Funke, with his principal place of operations at
Universitat Munster, Albert Schweitzer-Stra(BETA)e 33, D-48149, Munster, Federal
Republic of Germany, ("Recipient").

     WHEREAS, Company is willing to supply within the protection of a
confidential relationship, the DNA MassArray(TM) Basic System Plus and related
materials listed on Schedule A attached hereto ("Evaluation Item") to Recipient
solely for evaluating whether to enter in the currently proposed business
arrangement with Company ("Evaluation");

     WHEREAS, Recipient desires to have access to the Evaluation Item and is
aware of the nature of the Evaluation Item, and is willing to enter in a
confidential relationship and to use and test the Evaluation Item and report to
Company on the performance of the Evaluation Item;

     NOW, THEREFORE, in consideration of the foregoing and the mutual covenants
hereinafter set forth, the parties hereby agree as follows:

     1.  Use of DNA MassArray(TM) Basic System and SpectroChip(TM) License.
         -------------------------------------------------------------------
 Subject to the terms of this Agreement Company grants to Recipient    ***
                         ***
             ***         The Company shall at all times retain all title to and
ownership of the Evaluation Item and all ancillary products thereof. Recipient
agrees to use the Evaluation Item only in the ordinary course of testing and
comparing it's performance against comparable technologies in the Recipient's
facility, and Recipient will not reproduce or modify the Evaluation Item or any
portion thereof. Recipient shall not rent, sell, lease or otherwise transfer the
Evaluation Item or any part thereof or use it for the benefit of a third party.
Recipient shall not reverse assemble, reverse compile or reverse engineer the
Evaluation Item, or otherwise attempt to discover any Evaluation Item underlying
Proprietary Information (as that term is defined below).

     2.  Business Terms. All payments herein are for the use of Company's
         --------------
Evaluation Item and the services required for the operation of the Evaluation
Item including training and support.

i.                                 ***
               ***            After the completion of the initial     ***
 Beta-test period the Evaluation Item cost will be          ***
               ***


     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

Confidential                       Page 1
<PAGE>

SEQUENOM BETA TEST AGREEMENT        [LOGO]                                   2/6

ii.     ***     fee during the Beta-site period for all tests performed for
     comparison of Evaluation Item with other DNA analysis methods and with
     results of comparison tests reported to SEQUENOM. All samples being
     analyzed using the Evaluation Item for routine laboratory testing shall
     have an Element fee of  ***  (the 'Element Fee'); An "Element
     represents                 ***
                                      ***
                                      ***
iii. Monthly Maintenance Fee of       ***      that includes Evaluation Item
     support and the Company Bioinformatics Workstation updates *** commencing
     upon installation of the Evaluation Item.
iv.  A     ***     Royalty will be assessed on all reimbursements for test
     results obtained using the Evaluation Item on routine laboratory tests
     outside of the evaluation activities.
v.   One Company senior scientist designated for on-site support during the
     Beta-test period to facilitate the technology transfer and SYSTEM start-up.
     Recipient shall provide the Company scientist full access to the Contracted
     Item at the Recipient's facility during regular business hours.
vi.  Agreement is contingent on the use of authorized consumables provided from
     Company.

     3.  Confidentiality; Ownership. Recipient acknowledges that, in the course
         --------------------------
of using the Evaluation Item and performing its duties under this Agreement, it
may obtain information relating to the Evaluation Item and/or Company
("Proprietary Information"). Such Proprietary Information shall belong solely to
Company and includes, but, is not limited to, the existence of the Evaluation
Item, its features and mode of operation, this Agreement, trade secrets, know-
how, inventions (whether or not patentable), techniques, processes, programs,
ideas, algorithms, schematics, testing procedures, software design and
architecture, computer code, internal documentation, design and function
specifications, product requirements, problem reports, analysis and performance
information, software documents, and other technical, business, product,
marketing and financial information, plans and data. In regard to this
Proprietary Information:

     (a) Recipient shall not during the term of this Agreement and for a period
     of at least three (3) years after its termination, use (except as expressly
     authorized by this Agreement) or disclose Proprietary Information without
     the prior written consent of Company unless such Proprietary Information
     becomes part of the public domain without breach of this Agreement by
     Recipient, its officers, directors, employees or agents.

     (b) During the period specified in (a) above, Recipient agrees to take all
     reasonable measures to maintain the Proprietary Information and Evaluation
     Item in confidence.

     (c) During the period specified in (a) above, Recipient will disclose the
     Evaluation Item and Proprietary Information only to those of its employees
     and consultants as are necessary for the use expressly and unambiguously
     licensed hereunder, and only after such employees and contractors have
     agreed in writing to be bound by the provisions of this Agreement.
     Recipient shall not, without the prior written consent of Company,

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

Confidential                       Page 2
<PAGE>

SEQUENOM BETA TEST AGREEMENT        [LOGO]                                   3/6

     disclose or otherwise make available the Evaluation Item or any ancillary
     products to any third party.

     (d) Recipient hereby assigns to Company any invention, idea or know-how
     (whether or not patentable) that is conceived, learned or reduced to
     practice in the course of performance under this Agreement and any patent
     rights, trade secret rights, mask work rights, sui generis database rights
     and all other intellectual and industrial property rights of any sort with
     respect thereto. Recipient agrees to take any action reasonably requested
     by Company to evidence, perfect, obtain, maintain, enforce or defend the
     foregoing.

     4.  Reports.
         -------

     Company senior scientist, assisted by Recipient, shall provide written
     reports bi-monthly commencing after the date of this Agreement.  Reports
     shall disclose:                       ***
                                      ***
                                      ***
                                      ***



     5  WARRANTY DISCLAIMER.
        -------------------

The parties acknowledge that the Evaluation Item is for use in a Beta test.
COMPANY DISCLAIMS ALL WARRANTIES RELATING TO THE EVALUATION ITEM, EXPRESS OR
IMPLIED, INCLUDING, BUT NOT LIMITED TO, ANY WARRANTIES AGAINST INFRINGEMENT OF
THIRD-PARTY RIGHTS, MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE.

     6.  Limitation of Remedies and Damages.
         ----------------------------------

COMPANY SHALL NOT BE RESPONSIBLE OR LIABLE WITH RESPECT TO ANY SUBJECT MATTER OF
THIS AGREEMENT UNDER ANY CONTRACT, NEGLIGENCE, STRICT LIABILITY OR OTHER THEORY
(A) FOR LOSS OR INACCURACY OF DATA OR COST OF PROCUREMENT OF SUBSTITUTE GOODS,
SERVICES OR TECHNOLOGY, OR (B) FOR ANY INDIRECT, INCIDENTAL OR CONSEQUENTIAL
DAMAGES INCLUDING, BUT NOT LIMITED TO LOSS OF REVENUES AND LOSS OF PROFITS.
COMPANY SHALL NOT BE RESPONSIBLE FOR ANY MATTER BEYOND ITS REASONABLE CONTROL.

     7.  Nonassignability. Neither the rights nor the obligations arising under
         ----------------
this Agreement are assignable or transferable by Recipient, and any such
attempted assignment or transfer shall be void and without effect.

     8.  Execution of Agreement, Controlling Law, Attorneys' Fees and
         ------------------------------------------------------------
Severability. This Agreement shall become effective only upon its execution by
- -------------
both Company and Recipient and it shall be governed by and construed in
accordance with the laws of the Federal Republic of

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

Confidential                       Page 3
<PAGE>

SEQUENOM BETA TEST AGREEMENT        [LOGO]                                   4/6

Germany without regard to the conflicts of laws provisions therein. In any
action to enforce this Agreement the prevailing party will be entitled to costs
and attorneys' fees. In the event that any of the provisions of this Agreement
shall be held by a court or other tribunal of competent jurisdiction to be
unenforceable, such provisions shall be limited or eliminated to the minimum
extent necessary so that this Agreement shall otherwise remain in full force and
effect and enforceable.

     9.  Entire Agreement. This Agreement constitutes the entire agreement
         ----------------
between the parties pertaining to the subject matter hereof, and any and all
written or oral agreements previously existing between the parties are expressly
cancelled. Any modifications of this Agreement must be in writing and signed by
both parties.

     10.  Equitable Relief. Recipient acknowledges and agrees that due to the
          ----------------
unique nature of Company's Proprietary Information, there can be no adequate
remedy at law for any breach of its obligations hereunder, that any such breach
may allow Recipient or third parties to unfairly compete with Company resulting
in irreparable harm to Company, and therefore, that upon any such breach or
threat thereof, Company shall be entitled to injunctions and other appropriate
equitable relief in addition to whatever remedies it may have at law.

     11.  Termination. This Agreement may be terminated by Company without cause
          -----------
with fourteen (14) days' written notice to the Recipient at the address listed
above, or immediately upon notice of any breach by Recipient of the provisions
of this Agreement, and in any case will terminate six (6) months after the
initiation of the first reportable test at the Recipient's facility. Company and
Recipient will enter into good faith discussions sixty (60) days prior to the
termination of the Beta Site Agreement to negotiate a full DNA MassArrayTM
license Agreement. If no full license Agreement has been established upon
termination, the license granted hereunder shall terminate and Recipient shall
immediately return the Evaluation Item, together with any and all documents,
notes and other materials regarding the Evaluation Item to Company, including,
without limitation, all Proprietary Information and all copies and extracts of
the foregoing, but the terms of this Agreement will otherwise remain in effect.

     12.  PUBLIC ANNOUNCEMENTS. Any announcements or similar publicity with
respect to the execution of this Agreement shall be agreed upon between the
Parties in advance of such announcement, with such approval not unreasonable
withheld. Both Parties understand that this Agreement is likely to be of
interest to investors, analysts and others, and that the Parties therefore may
make such public announcements with respect thereto. The Parties agree that any
such announcement will not contain confidential business or technical
information and, if disclosure of confidential business or technical information
is required by law or regulation, will make reasonable efforts to minimize such
disclosure and obtain confidential treatment for any such information which is
disclosed to a governmental agency or group. Each Party agrees to provide to the
other Parties a copy of any public announcement as soon as reasonably
practicable under the circumstances prior to its scheduled release. Except under
extraordinary circumstances, each Party shall provide the other with an advance
copy of any press release at least five (5) business days prior to the scheduled
disclosure. Each Party shall have the right to expeditiously


Confidential                       Page 4
<PAGE>

SEQUENOM BETA TEST AGREEMENT        [LOGO]                                   5/6

review and recommend changes to any announcement regarding this Agreement or the
subject matter of this Agreement. Except as otherwise required by law, the Party
whose press release has been reviewed shall remove any information the reviewing
Party reasonably deems to be inappropriate for disclosure.

     13.  PUBLICATION - Recipient shall have the right to publish the results of
the work conducted by University under this Agreement to the extent such results
do not contain Confidential Information of Company as per Article 3. and
provided Company has the opportunity to review and comment on any proposed
manuscripts describing said work thirty (30) days prior to their submission for
publication. Recipient agrees to consider Company's comments prior to
publication. However, if such submission would cause the loss of significant
foreign patent rights, Recipient will, at its option, either delete the enabling
portion of the proposed publication, or withhold publication for an additional
sixty (60) days until patent filings are completed.



SEQUENOM, GmbH                        Dr. med. Harald Funke, Universitat Munster



By: /s/ illegible                     By: /s/ Harold Funke
   ---------------------------------     ---------------------------------------

Name (Print): illegible Schmidt       Name (Print): Harold Funke
             -----------------------               -----------------------------

Title: Director Business Development  Title: Priv. - Doz.
      ------------------------------        ------------------------------------


By: /s/ R. Raist                      By: /s/ illegible
   ---------------------------------     ---------------------------------------

Name (Print): R. Raist                Name (Print): Wilmer
             -----------------------               -----------------------------

Title: Commercial Director            Title: Administrative Officer
      ------------------------------        ------------------------------------

Confidential                       Page 5
<PAGE>

SEQUENOM BETA TEST AGREEMENT       [LOGO]                                   6/6


                                   Schedule A


DNA MassArray(TM) Basic System Plus Evaluation Items include:

     .  High-speed Bruker/SEQUENOM Array Mass Spectrometer
     .  GeSIM/SEQUENOM Monochannel Nanoplotter
     .  SEQUENOM BioMASS Informatics Workstation
     .  Beckman MultimekTM Instrument with SEQUENOM magnetic lifters

The SEQUENOM 96 D SpectroChip(TM) - including the reaction unit and reagents
necessary to characterize a PCR Product for SNP analysis - will be made
available     ***     during the Beta test period for all tests that are
performed for comparison of DNA MassArray(TM) performance with other DNA
analysis methods with result reported to SEQUENOM. For all samples being
analyzed using DNA MassArray(TM) for routine laboratory testing (without a
performance report to SEQUENOM)a price of              ***
                                     ***.

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

Confidential                       Page 6

<PAGE>

                                                                   EXHIBIT 10.23

                         SEQUENOM BETA TEST AGREEMENT

This Agreement, dated July 15, 1999, is made by and between SEQUENOM, Inc., a
corporation with its principal place of business located at 11555 Sorrento
Valley Rd, San Diego, CA, 92121-1331, ("Company"), and Genzyme Corporation, a
corporation with its place of business at One Mountain Road, P.O. Box 9322,
Framingham, MA, 01701-9322 ("Recipient").

     WHEREAS, Company is willing to supply within the protection of a
confidential relationship, the DNA MassArray(TM) system and related materials
listed on Schedule A attached hereto ("Evaluation Item") to Recipient by the
week of August 16, 1999 solely for evaluating whether to enter full commercial
business arrangement with the Company ("Evaluation");

     WHEREAS, Recipient desires to have access to the Evaluation Item and is
aware of the nature of the Evaluation Item, and is willing to enter a
confidential relationship and to use and test the Evaluation Item and report to
Company on a confidential basis the performance of the Evaluation Item;

     NOW, THEREFORE, in consideration of the foregoing and the mutual covenants
hereinafter set forth, the parties hereby agree as follows:

     1.   Use of DNA MassArray(TM) and SpectroChip(TM) License. Subject to the
          ----------------------------------------------------
terms of this Agreement, Company grants to Recipient            ***
                                      ***
                                      ***                   The Company shall
at all times retain all title to and ownership of the Evaluation Item and all
ancillary products thereof. Recipient agrees to use the Evaluation Item only in
the ordinary course of testing, and Recipient will not reproduce or modify the
Evaluation Item or any portion thereof. Recipient shall not rent, sell, lease or
otherwise transfer the Evaluation Item or any part thereof or use it for the
benefit of a third party. Recipient shall not reverse assemble, reverse compile
or reverse engineer the Evaluation Item, or otherwise attempt to discover any
Evaluation Item underlying Proprietary Information (as that term is defined
below).

     2.   Business Terms. All fees herein are for the use of Company's
          --------------
Evaluation Item and the services required for the operation of the Evaluation
Item including training and support.

i.                               ***
          ***   After the completion of the initial *** Beta-test period,
     Recipient may purchase the Evaluation Item for       ***   .

ii.       ***  fee during the Beta-test period for all tests performed for the
     objective evaluation of the Evaluation Item and/or the comparison of
     Evaluation Item with other DNA analysis methods and with results of
     evaluation and comparison tests (other than patient information) reported
     to SEQUENOM on a confidential basis. All samples being



     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

Confidential                       Page 1
<PAGE>

Beta Test Agreement

     analyzed using the Evaluation Item for testing other than for the purposes
     as set forth in the preceding sentence shall have an Element fee of ***
     (the "Element Fee"); An "Element" represents          ***
                                      ***
                                      ***

iii. A Maintenance Fee that includes Evaluation Item Support and Company
     Bioinformatics Workstation updates ("Maintenance") of     ***     ***
     ***. Evaluation Item Maintenance shall include installation, training,
     ongoing maintenance and support for the term of the Evaluation provided by
     the Company. The Maintenance Fee is strictly for this Evaluation Item
     during the evaluation period. Pricing of a maintenance fee on any future
     agreements would be dependent on the nature of that agreement.

     3.  Confidentiality; Ownership. Recipient acknowledges that, in the course
         --------------------------
of using the Evaluation Item and performing its duties under this Agreement, it
may obtain information relating to the Evaluation Item and/or Company ("Company
Proprietary Information").  Such Company Proprietary Information shall belong
solely to Company and includes, but is not limited to, the existence of the
Evaluation Item, its features and mode of operation, this Agreement, trade
secrets, know-how, inventions (whether or not patentable), techniques,
processes, programs, ideas, algorithms, schematics, testing procedures, software
design and architecture, computer code, internal documentation, design and
function specifications, product requirements, problem reports, analysis and
performance information, software documents, and other technical, business,
product, marketing and financial information, plans and data.

     Company acknowledges that, in the course of the Recipient using the
Evaluation Item and performing its duties under this Agreement, it may obtain
information relating to the Recipient's assays and/or the Recipient ("Recipient
Proprietary Information"). Such Recipient Proprietary Information shall belong
solely to Recipient and includes, but is not limited to the existence of such
assays, any know-how, techniques, processes, and other recipient specific
technical, business, product, marketing and financial information, plans, and
data. Further, Recipient shall own all discoveries, inventions, (whether or not
patentable), data and other results arising from the use of the Recipient's
***    with the Evaluation Item, but only to the extent that such discovery,
invention, data or results relates to the use and operation of Recipient's
***     and Recipient expressly reserves all intellectual property rights
therein with the exception of those enumerated in Paragraph 3 (d) below.


     In regard to both Company and Recipient ("Parties") Proprietary
Information:

          (a) Parties shall not, during the term of this Agreement, and for a
          period of at least three (3) years after its termination, use (except
          as expressly authorized by this Agreement) or disclose Proprietary
          Information without the prior written consent of the other party
          unless such Proprietary Information becomes part of the public


     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

Confidential                       Page 2
<PAGE>

Beta Test Agreement

          domain without breach of this Agreement by either party, its officers,
          directors, employees or agents.

          (b) During the period specified in (a) above, both parties agree to
          take all reasonable measures to maintain the Proprietary Information
          and Evaluation Item in confidence.

          (c) During the period specified in (a) above, both Parties will
          disclose the Evaluation Item and Proprietary Information only to those
          of its employees and consultants as are necessary for the use
          expressly and unambiguously licensed hereunder, provided such
          employees and contractors are subject to confidentiality obligations
          consistent with those set forth herein. Recipient shall not, without
          the prior written consent of Company, disclose or otherwise make
          available the Evaluation Item or any ancillary products to any third
          party.

          (d) Recipient hereby assigns to Company any invention, improvement,
          idea or know-how (whether or not patentable) that is conceived,
          learned or reduced to practice in the course of performance under this
          Agreement, but only to the extent that such invention, idea, or know-
          how relates to the use and operation of the Evaluation Item and any
          patent rights, trade secret rights, mask work rights, sui generis
          database rights and all other intellectual and industrial property
          rights of any sort with respect thereto. Recipient agrees to take any
          action reasonably requested by Company to evidence, perfect, obtain,
          or maintain the foregoing.

     4.  Reports. A Company senior scientist, assisted by Recipient, shall
         -------
provide written reports monthly commencing after the date of the first test at
the Recipient's facility. Reports shall disclose:             ***
                                      ***
                                      ***
                                      ***

     5.  WARRANTY DISCLAIMER. The parties acknowledge that the Evaluation Item
         -------------------
is for use in a Beta test. COMPANY DISCLAIMS ALL WARRANTIES RELATING TO THE
EVALUATION ITEM, EXPRESS OR IMPLIED, INCLUDING, BUT NOT LIMITED TO, ANY
WARRANTIES AGAINST INFRINGEMENT OF THIRD-PARTY RIGHTS, MERCHANTABILITY AND
FITNESS FOR A PARTICULAR PURPOSE.

     6.  Limitation of Remedies and Damages. COMPANY SHALL NOT BE RESPONSIBLE OR
         ----------------------------------
LIABLE WITH RESPECT TO ANY SUBJECT MATTER OF THIS AGREEMENT UNDER ANY CONTRACT,
NEGLIGENCE, STRICT LIABILITY OR OTHER THEORY (A) FOR LOSS OR INACCURACY OF DATA
OR COST OF PROCUREMENT OF SUBSTITUTE GOODS, SERVICES OR TECHNOLOGY, OR (B) FOR
ANY INDIRECT, INCIDENTAL OR CONSEQUENTIAL DAMAGES INCLUDING, BUT


     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

Confidential                       Page 3
<PAGE>

Beta Test Agreement

NOT LIMITED TO LOSS OF REVENUES AND LOSS OF PROFITS. COMPANY SHALL NOT BE
RESPONSIBLE FOR ANY MATTER BEYOND ITS REASONABLE CONTROL.

     7.  Nonassignability. Neither the rights nor the obligations arising under
         ----------------
this Agreement are assignable or transferable by Recipient, and any such
attempted assignment or transfer shall be void and without effect.

     8.  Execution of Agreement, Controlling Law. Attorneys' Fees and
         ------------------------------------------------------------
Severability. This Agreement shall become effective only upon its execution by
- ------------
both Company and Recipient and it shall be governed by and construed in
accordance with the laws of the Commonwealth of Massachusetts without regard to
the conflicts of laws provisions therein. In the event that any of the
provisions of this Agreement shall be held by a court or other tribunal of
competent jurisdiction to be unenforceable, such provisions shall be limited or
eliminated to the minimum extent necessary so that this Agreement shall
otherwise remain in full force and effect and enforceable.

     9. Entire Agreement. This Agreement constitutes the entire agreement
        ----------------
between the parties pertaining to the subject matter hereof, and any and all
written or oral agreements previously existing between the parties are expressly
canceled with the exception of any prior Confidentiality Agreement executed
between the two Parties. Any modifications of this Agreement must be in writing
and signed by both parties.

     10.  Equitable Relief. Recipient acknowledges and agrees that due to the
          ----------------
unique nature of Company's Proprietary Information, there may be no adequate
remedy at law for any breach of its obligations hereunder, that any such breach
may allow Recipient or third parties to unfairly compete with Company resulting
in irreparable harm to Company, and therefore, upon any such breach or threat
thereof, Company shall be entitled to seek injunctions and other appropriate
equitable relief in addition to whatever remedies it may have at law.

     11.  Termination. This Agreement maybe terminated by Company or Recipient
          -----------
for any reason or no reason upon twenty-one (21) days' written notice to the
other party at its address listed above, or immediately upon notice of any
breach by either party of the provisions of this Agreement that has not been
cured within 10 days, and in any case will terminate six (6) months after the
initiation of the Evaluation at the Recipient's facility. Upon termination, all
payments owing Company up to the point of the date of termination shall be due
within thirty (30) days of the termination date and the license granted
hereunder shall terminate and Recipient shall immediately return the Evaluation
Item, together with any and all documents, notes and other materials regarding
the Evaluation Item to Company, including, without limitation, all Proprietary
Information and all copies and extracts of the foregoing, but the terms of this
Agreement, excluding Paragraph 2 will otherwise remain in effect.

     Company and Recipient will enter into good faith discussions sixty (60)
days prior to the termination of the Beta Site Agreement to either extend the
current Agreement or negotiate a full DNA MassArray(TM) license Agreement.



Confidential                       Page 4
<PAGE>

Beta Test Agreement

     12.  Public Announcements. Any announcements or similar publicity with
          --------------------
respect to the execution of this Agreement shall be agreed upon between the
Parties in advance of such announcement. Both Parties understand that this
Agreement is likely to be of significant interest to investors, analysts and
others, and that the Parties therefore may make such public announcements with
respect thereto. The Parties agree that any such announcement will not contain
confidential business or technical information and, if disclosure of
confidential business or technical information is required by law or regulation,
will make reasonable efforts to minimize such disclosure and obtain confidential
treatment for any such information which is disclosed to a governmental agency
or group. Each Party agrees to provide to the other Parties a copy of any public
announcement as soon as reasonably practicable under the circumstances prior to
its scheduled release. Except under extraordinary circumstances, each Party
shall provide the other with an advance copy of any press release at least five
(5) business days prior to the scheduled disclosure. Each Party shall have the
right to expeditiously review and recommend changes to any announcement
regarding this Agreement or the subject matter of this Agreement. Except as
otherwise required by law, the Party whose press release has been reviewed shall
remove any information the reviewing Party reasonably deems to be inappropriate
for disclosure.

     13.  Publication. Recipient shall have the right to publish the results of
          -----------
the work conducted by Recipient under this Agreement to the extent such results
do not contain Confidential Information of Company as described in Paragraph 3
and provided Company has the opportunity to review and comment on any proposed
manuscripts describing said work thirty (30) days prior to their submission for
publication. Recipient agrees to make any changes as per the Company's comments
prior to publication. If such submission would cause the loss of significant
foreign patent rights, Recipient will, at its option, either delete the enabling
portion of the proposed publication, or withhold publication for an additional
ninety (90) days until U.S. patent filings are completed.

Sequenom, Inc.                           Genzyme Corporation

By /s/ Hubert Koster                     By /s/ Evan M. Lebson
   ----------------------------             ---------------------------------

             __________________                       _______________________
Name (Print) Hubert Koster               Name (Print) Evan M. Lebson
             ------------------                       -----------------------
Title:  President and CEO                Title  Vice President - Treasurer
        -----------------------                 -----------------------------

Confidential                       Page 5
<PAGE>

Beta Test Agreement

                                  Schedule A


DNA MassArray(TM) Basic System Plus Evaluation Items include:

- -    High-speed SpectroScan array mass spectrometer for
     separation, detection and characterization of the analyte molecules from a
     miniaturized array
- -    SpectroJET dispenser for nanoliter sample transfer;
- -    Automated Multipipettor;
- -    BioMASS(TM) Workstation for data management and interpretation; and
- -    Sequenom Magnetic Lifters.

The SEQUENOM 96 D SpectroChip(TM) will be made available     ***    during the
Beta test period for all tests that are performed for comparison of DNA
MassArray(TM) performance with other DNA analysis methods with result reported
to SEQUENOM on a confidential basis.



     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

Confidential                       Page 6

<PAGE>

                                                                   EXHIBIT 10.24
                         SPONSORED RESEARCH AGREEMENT


THIS AGREEMENT, effective as of September 15, 1994 (the "Effective Date"), is
made by and between the TRUSTEES OF BOSTON UNIVERSITY (hereinafter referred to
as "UNIVERSITY") having an address at 881 Commonwealth Avenue, Boston,
Massachusetts 02215 and Sequenom, Inc., a corporation organized under the laws
of Delaware, whose address is c/o Techno Venture Management, 101 Arch Street,
Suite 1950, Boston, Massachusetts 02110 (hereinafter referred to as "SPONSOR").

WHEREAS, the research program contemplated by this Agreement is of mutual
interest and benefit to UNIVERSITY and SPONSOR and will further the
instructional and research objectives of the UNIVERSITY in a manner consistent
with its status as a non-profit, tax-exempt, educational institution,

NOW, THEREFORE, in consideration of the mutual covenants and promises herein
contained, UNIVERSITY and SPONSOR agree as follows:


                             I.  RESEARCH PROGRAM

1.1  UNIVERSITY undertakes to conduct the research program ("Research Program")
described in the attached Exhibit A, "Statement of Work," and will furnish the
facilities necessary to carry out such Research Program.  The Research Program
will be under the direction of Dr. Charles Cantor, as Principal Investigator,
and Dr. Hubert Koster, as SPONSOR's Technical Representative.  SPONSOR may
change its Technical Representative at any time upon written notice to
UNIVERSITY.

1.2  SPONSOR understands that UNIVERSITY's primary mission is education and
advancement of knowledge and that the Research Program will be performed in a
manner best suited to carry out that mission.  The manner of performance of the
Research Program shall respect this mission and shall be determined jointly by
the Principal Investigator and the Technical Representative.  SPONSOR
acknowledges that UNIVERSITY does not guarantee specific results.

1.3  UNIVERSITY shall promptly advise SPONSOR if for any reason the Principal
Investigator ceases to be available to work on the Research Program.  If
UNIVERSITY and SPONSOR cannot agree on a qualified replacement scientist,
SPONSOR may terminate this Agreement on thirty (30) days' written notice to
UNIVERSITY.


                          II.  PERIOD OF PERFORMANCE

The Research Program shall be conducted during the twelve-month period from
September 15, 1994 through September 14, 1995; provided, however, that the
parties may extend the term of the Research Program with the unanimous agreement
of UNIVERSITY, SPONSOR and the Principal Investigator.

<PAGE>

                               III.  COMPENSATION

3.1  in consideration of UNIVERSITY's agreement to undertake the research
described in Exhibit A, SPONSOR will pay UNIVERSITY a total of *** during the
term of the Research Program, to be expended in accordance with the budget set
forth on Exhibit F. The program funds will be paid to UNIVERSITY in installments
as set forth in the following schedule of amounts and due dates:

          ***            ***                ***             ***

          ***            ***                ***             ***

Portions of this page have been omitted pursuant to a request for Confidential
Treatment and filed separately with the Commission. Payments will be made in the
name of "Trustees of Boston University", and will be sent to Boston University,
Grant Accounting, 25 Buick Street, Boston, Massachusetts 02215. UNIVERSITY shall
provide SPONSOR with a final financial accounting of all costs incurred and all
funds received by UNIVERSITY under this Section 3.1 within ninety (90) days
after the termination of this Agreement. UNIVERSITY shall enclose a check
payable to SPONSOR in the amount of any unexpended balance of such funds.

3.2  SPONSOR shall have tide to all equipment purchased and/or fabricated by
UNIVERSITY with funds provided by SPONSOR under this Agreement.  Promptly after
termination of the Agreement, SPONSOR shall direct UNIVERSITY regarding the
delivery of such equipment.  SPONSOR shall bear any expenses associated with
such delivery, provided that UNIVERSITY complies with the written instructions
of SPONSOR.


                    IV.  RECORDS, CONSULTATION AND REPORTS

4.1  UNIVERSITY will use its best efforts, reasonable under the circumstances,
to ensure that its employees prepare and maintain records, including bound
laboratory notebooks maintained in accordance with standard scientific
procedures, containing all appropriate data reflecting the results of the
Research Program.  During the performance of the Research Program, the Technical
Representative shall have reasonable access to consult informally with the
Principal Investigator regarding the research, both personally and by telephone.
UNIVERSITY agrees to furnish SPONSOR, upon request, with reasonable amounts of
any biological, chemical or physical materials ("Materials") arising in the
course of the Research Program ("Program Materials").  The Principal
Investigator shall deliver a written report to the Technical Representative
every four (4) months during the period of performance of the Research Program.
A final report setting forth the significant research findings shall be prepared
by the Principal Investigator and submitted to the Sponsor within ninety (90)
days following the expiration of the term of this Agreement or the effective
date of early termination, as set forth in Article XI.


     ***    Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                      -2-
<PAGE>

                        V.  PUBLICATION AND COPYRIGHTS

5.1  UNIVERSITY and its investigators will be free to publicly disclose (through
journals, lectures, or otherwise) the results of the Research Program, provided
that UNIVERSITY shall have provided a copy of the proposed publication to
SPONSOR at least sixty (60) days prior to the intended submission of any written
publication or any other public disclosure to allow SPONSOR to determine whether
any patentable invention or Confidential Information (as defined in the form of
confidentiality agreement set forth on Exhibit B) would be disclosed.

     If the proposed disclosure contains Confidential Information, UNIVERSITY
shall remove or cause the author to remove such Confidential Information prior
to its submission for publication or other public disclosure.  If the proposed
disclosure would disclose a patentable invention, UNIVERSITY shall, at the
request of SPONSOR, delay or cause the author to delay submission of the work
for publication or other public disclosure for up to an additional sixty (60)
days to enable UNIVERSITY or SPONSOR to file a patent application.

5.2  Title to any copyrights or copyrightable material first produced or
composed in the performance of the Research Program shall remain with
UNIVERSITY; provided, however, that UNIVERSITY shall grant to SPONSOR an
irrevocable, royalty-free, nontransferable, non-exclusive right to reproduce,
translate and use all such copyrightable material; except that such right with
respect to computer software and its programming documentation is applicable
only to computer software and its programming documentation specified to be
developed and delivered under the Statement of Work, Exhibit A. UNIVERSITY shall
not assign or license its rights under such copyrights or copyrightable material
without the prior written consent of SPONSOR.


            VI.  CONFIDENTIAL INFORMATION AND PROPRIETARY MATERIALS

SPONSOR may wish, from time to time, in connection with work contemplated under
this Agreement, to disclose confidential information to UNIVERSITY personnel.
To protect the confidentiality of such information, SPONSOR may request the
Principal Investigator and other research personnel to sign confidentiality
agreements with SPONSOR, in the form of Exhibit B hereto.

In addition, from time to time, SPONSOR may provide UNIVERSITY personnel with
Materials for use in the Research Project; such Materials shall be proprietary
to SPONSOR if they were developed prior to or outside the performance of this
Agreement ("Proprietary Materials").  SPONSOR may request the Principal
Investigator and other research personnel to execute materials transfer
agreements with SPONSOR.

Except as otherwise provided in Section 5. 1, UNIVERSITY will not be responsible
for any failure of individual performance under such confidentiality and
materials transfer agreements.


                                VII.  PUBLICITY

Neither party shall use the name of the other party or of any investigator in
any advertising or promotional material without the prior written approval of
the other, except that SPONSOR shall

                                      -3-
<PAGE>

have the right to identify UNIVERSITY and to disclose the terms of this
Agreement in any prospectus, offering memorandum, or other document or filing
required by applicable securities laws or other applicable law or regulation,
provided that SPONSOR shall have given UNIVERSITY at least five (5) days prior
written notice of the proposed text of any such identification or disclosure for
the purpose of giving UNIVERSITY the opportunity to comment on such proposed
text. SPONSOR may, and UNIVERSITY shall, however, acknowledge SPONSOR's support
for the investigations being pursued under this Agreement. In any such
statements, the relationship of the parties shall be accurately and
appropriately described.


                         VII.  INVENTIONS AND PATENTS

8.1  SPONSOR shall own all rights in any Inventions discovered or conceived
solely by its employees or consultants and first reduced to practice in the
course of the Research Program without any significant use of UNIVERSITY
facilities or equipment ("Sponsor Inventions").  UNIVERSITY shall own all rights
in any Inventions either (i) discovered or conceived solely by its employees or
(ii) first reduced to practice in the course of the Research Program with
significant use of UNIVERSITY facilities or equipment ("University Inventions").
SPONSOR and UNIVERSITY shall jointly own rights in any Inventions discovered or
conceived jointly by an employee or consultant of SPONSOR and an employee of
UNIVERSITY and first reduced to practice in the course of the Research Program
without any significant use of UNIVERSITY facilities or equipment ("Joint
Inventions").  For the purposes of this Section 8. 1, the term "significant use"
shall have the meaning set forth in the Boston University Patent Policy, Charles
River Campus (as amended, 11/12/91), a copy of which is attached as Exhibit E.
The term "Inventions" shall include all discoveries or inventions (whether or
not patentable) that are discovered, conceived, or reduced to practice in the
course of the Research Program funded by SPONSOR, including but not limited to
processes, methods, formulas and techniques.

8.2  (a)  UNIVERSITY shall make prompt written disclosure to SPONSOR of any
Invention made by UNIVERSITY personnel or jointly by UNIVERSITY personnel and
SPONSOR personnel during the course of the Research Program.

     (b)  Upon such written disclosure, SPONSOR shall have the right, at
SPONSOR's request and expense, to have UNIVERSITY file the necessary papers for
obtaining patent protection in any and all countries of the world which SPONSOR,
in its sole judgment, determines are of sufficient interest to merit such
filing.

     (c)  Patent applications relating to a University Invention shall be filed,
prosecuted and maintained by UNIVERSITY in its name, using patent counsel
reasonably acceptable to SPONSOR.

     (d)  Patent applications relating to a Joint Invention shall be filed,
prosecuted and maintained by SPONSOR as mutually agreed by the parties, and
UNIVERSITY and SPONSOR shall together select independent patent counsel
satisfactory to both parties to prepare and prosecute any such application(s).

     (e)  Patent applications relating to a Sponsor Invention shall be filed,
prosecuted and maintained by SPONSOR using patent counsel reasonably acceptable
to UNIVERSITY.

                                      -4-
<PAGE>

     (f)  As regards 8.2(c), 8.2(d) and 8.2(e), both parties shall have the
right to review and comment upon applications and correspondence with the Patent
Office and shall be provided with drafts thereof sufficiently in advance to
reasonably allow for such review and comment.

     (g)  UNIVERSITY agrees that it will cause to be signed by concerned
UNIVERSITY personnel all documents of assignment or other documents necessary to
obtain patent protection as set forth above, and that UNIVERSITY will do
whatever SPONSOR reasonably requests to obtain and maintain such patent rights,
at the expense of SPONSOR.

     (h)  If SPONSOR elects not to have a patent application filed in any
country with respect to a particular University Invention or Joint Invention,
SPONSOR shall advise UNIVERSITY of such fact within ninety (90) days from the
date the Invention was disclosed to SPONSOR by UNIVERSITY. UNIVERSITY may then,
at its own expense, file and prosecute such patent application, and such patent
application and any patents issuing therefrom shall not be included within the
license option granted to SPONSOR pursuant to Section 8.3(a) of this Agreement,
and UNIVERSITY shall be free to license its rights in such patent to any party.

8.3  (a)  UNIVERSITY hereby grants SPONSOR a first option to acquire ***
                                   ***
                                   ***            Said right must be exercised
by written notice to UNIVERSITY within six (6) months after receiving from
UNIVERSITY written notice of the filing of a patent application describing such
Invention.

     (b)  UNIVERSITY hereby grants SPONSOR a first option to acquire ***
                                   ***
                                   ***
                                   ***            Said right must be exercised
by written notice to UNIVERSITY and shall remain in effect during the term of
this Agreement and thereafter for a period of six (6) months.

     (c)  UNIVERSITY hereby grants SPONSOR a first option to acquire ***
                                   ***
                                   ***            Said right must be exercised
by written notice to UNIVERSITY and shall remain in effect during the term of
this Agreement and thereafter for a period of six (6) months.

     (d)  If SPONSOR elects to exercise any of its rights to acquire *** license
under Sections 8.3(a), 8.3(b), or 8.3(c) above, both parties agree to negotiate
mutually agreeable license terms in good faith. Any negotiations regarding a
particular invention, including the execution of an agreement, shall be
completed within six (6) months of written notice to UNIVERSITY of SPONSOR's
exercise of its option for such invention. If the parties fail to agree to the
terms and conditions of such license agreement within the six-month negotiation
period, UNIVERSITY shall be free to license that particular invention to a third
party; provided, however, that for a period of three (3) years after the six-
month negotiation period, UNIVERSITY shall not grant

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                      -5-
<PAGE>

any rights in such invention without first offering SPONSOR the opportunity for
ninety (90) days from the date of the offer to meet the terms of such proposed
grant of rights. If SPONSOR fails to notify UNIVERSITY in writing within such
ninety-day period that it has accepted such terms, SPONSOR shall be deemed to
have rejected the offer, and UNIVERSITY may license its rights in such invention
to other parties. If SPONSOR notifies UNIVERSITY within such ninety-day period
that it accepts such offer, UNIVERSITY shall be deemed to have entered into a
binding license agreement with respect to such terms.

8.4  UNIVERSITY and SPONSOR agree that the terms set forth on Exhibit D are
mutually agreeable and shall be included in any license granted to SPONSOR
pursuant to paragraph 8.3.

8.5  UNIVERSITY hereby grants SPONSOR a non-exclusive, worldwide, royalty-free,
perpetual license to use any results of the Research Program (including without
limitation all discoveries, data, Program Materials, and Inventions not
exclusively licensed to SPONSOR under Section 8.3) for internal research
purposes.


                                IX.  LIABILITY

9.1  SPONSOR shall defend, indemnify and hold harmless UNIVERSITY, and its
trustees, officers, employees and agents and their respective successors, heirs
and assigns (the "Indemnitees"), against any and all liability, damage, loss or
expense (including reasonable attorneys' fees and expenses of litigation) that
may be incurred by or imposed upon the Indemnitees, or any of them, in
connection with any claim, suit, demand, action or judgment arising out of the
following:

     (a)  the design, production, manufacture, sale, use in commerce, lease or
          promotion by SPONSOR or by an Affiliate or sublicensee of SPONSOR of
          any product, process or service relating to or developed pursuant to
          this Agreement; or
     (b)  any other activities to be carried out pursuant to this Agreement.

SPONSOR's indemnity under (a) shall apply to any liability, damage, loss or
expense whether or not it is attributable to the negligent activities of the
Indemnitees.  SPONSOR's indemnification under (b) shall not apply to any
liability, damage, loss or expense to the extent that it is attributable to the
negligence or willful misconduct of the Indemnitees.

9.2  UNIVERSITY makes no warranties, express or implied, as to any matter
     --------------------------------------------------------------------
whatsoever, including without limitation, the condition of the research or any
- ------------------------------------------------------------------------------
invention(s) or product(s).  Whether tangible, conceived, discovered, or
- ------------------------------------------------------------------------
developed under this Agreement; or the merchantability, or fitness for a
- ------------------------------------------------------------------------
particular purpose of the research or any such invention or product.  UNIVERSITY
- --------------------------------------------------------------------------------
shall not be liable for any direct, consequential, or other damage suffered by
- ------------------------------------------------------------------------------
SPONSOR, any licensee, or any others resulting from the use of the research or
- ------------------------------------------------------------------------------
any such invention or product.
- -----------------------------

                                      -6-
<PAGE>

                          X.  INDEPENDENT CONTRACTOR

For the purpose of this Agreement and all services to be provided hereunder, the
parties shall be, and shall be deemed to be, independent contractors and not
agents or employees of the other party.  Neither party shall have authority to
make any statements, representations or commitments of any kind, or to take any
action which shall be binding on the other party, except as may be explicitly
provided for herein or authorized in writing.


                          XI.  TERMS AND TERMINATION

11.1  Performance may be terminated by UNIVERSITY immediately upon written
notice to SPONSOR if circumstances beyond its control preclude continuation of
the Research Program.  SPONSOR may terminate this Agreement for any reason upon
ninety (90) days written notice to UNIVERSITY.

11.2  In the event that either party shall be in default of any of its
obligations under this Agreement and shall fail to remedy such default within
sixty (60) days after receipt of written notice thereof, the party not in
default shall have the option of terminating this Agreement by giving written
notice thereof.

11.3  Termination or cancellation of this Agreement shall not affect the rights
and obligations of the parties accrued prior to termination.  Upon any
termination hereof, UNIVERSITY shall be entitled to be compensated for all
reasonable expenses and uncancellable commitments incurred as of the effective
date of termination, not to exceed the total contract amount stated in 3.1
above.

11.4  Articles V, VII, VIII and IX and Sections 3.1 (the obligation for a final
accounting and refund), 3.2 and 4.1 (the obligation for a final report) shall
survive such termination.


                                 XII.  GENERAL

12.1  This Agreement may not be assigned by either party without the prior
written consent of the other party, except that SPONSOR may assign this
Agreement to an affiliate or to a successor in connection with the merger,
consolidation or sale of all or substantially all of its assets or that portion
of its business pertaining to the subject matter of this Agreement.

12.2  This Agreement constitutes the entire and only agreement between the
parties relating to the Research Program, and all prior negotiations,
representations, agreements and understandings are superseded hereby.  No
agreements altering or supplementing the terms hereof may be made except by
means of a written document signed by the duly authorized representatives of the
parties.

12.3  Any notice required by this Agreement shall be sufficiently given (i) upon
the date of receipt if delivered by hand, recognized national overnight courier,
confirmed facsimile transmission, or registered or certified mail, return
receipt requested, postage prepaid, or (ii) on

                                      -7-
<PAGE>

the third business day after mailing by first class mail, postage prepaid, to
the following addresses or facsimile numbers:

If to UNIVERSITY:

Boston University
Attention: Maureen Rodgers
Office of Sponsored Programs
25 Buick Street
Boston, MA 02215

Tel:  (617) 353-4365
Fax:  (617) 353-6660

If to SPONSOR:

Dr. Hubert Koster
SEQUENOM, Inc.
c/o TVM Techno Venture Management
101 Arch Street, Suite 1950
Boston, MA 02110

Tel:  (617) 345-9320
Fax:  (617) 345-9377



with a copy to:

SEQUENOM, Inc.
c/o TVM Techno Venture Management
101 Arch Street, Suite 1950
Boston, MA 02110
Attention:  President

Tel:  (617) 345-9320
Fax:  (617) 345-9377

or at such other addresses or facsimile numbers as may be designated by notice
given from time to time under the terms of this provision.

12.4  This Agreement shall be construed and enforced in accordance with the laws
of the Commonwealth of Massachusetts.

                                      -8-
<PAGE>

IN WITNESS WHEREOF, the parties have caused this Agreement to be executed by
their duly authorized representatives:

                                        TRUSTEES OF BOSTON UNIVERSITY


                                        By: /s/ John F. Imbergamo
                                            ------------------------------------
                                        Printed Name:  John F. Imbergamo
                                        Title:  Comptroller


                                        SEQUENOM, INC.


                                        By: /s/ illegible
                                            ------------------------------------
                                        Printed Name:
                                        Title:


I have read the foregoing Agreement and agree to comply with its terms.


                                        By: /s/ Charles R. Cantor
                                            ------------------------------------
                                        Printed Name:  Charles R. Cantor
                                        Title:  Principal Investigator

                                      -9-
<PAGE>


                                   EXHIBIT A

                               STATEMENT OF WORK



                                      ***
                                      ***
                                      ***
                                      ***
                                      ***
                                      ***
                                      ***


***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                   EXHIBIT B

                       CONFIDENTIAL DISCLOSURE AGREEMENT


     This Agreement, dated as of _______________, is between [Name of
Investigator] and Sequenom, Inc.

     In connection with the conduct of a research program pursuant to a
Sponsored Research Agreement dated as of December 1, 1994 among Sequenom, Inc.,
Charles Cantor and Boston University (the "Sponsored Research Agreement"), each
party may furnish to the other party certain confidential information relating
to its business for the sole purpose of conducting this research program.
Accordingly, the parties hereby agree as follows:

     1.  For purposes of this Agreement, the term "Confidential Information"
means any technical or business information furnished by one party (the
"Disclosing Party") to the other party (the "Receiving Party") in connection
with the research program under the Sponsored Research Agreement and
specifically designated as confidential.  Such Confidential Information may
include, without limitation, trade secrets, know-how, inventions, technical data
or specifications, testing methods, business or financial information, research
and development activities, product and marketing plans, and customer and
supplier information.  Confidential Information that is disclosed in writing
shall be marked with a legend indicating its confidential status.  Confidential
Information that is disclosed orally or visually shall be documented in a
written notice prepared by the Disclosing Party and delivered to the Receiving
Party within thirty (30) days of the date of disclosure; such notice shall
summarize the Confidential Information disclosed to the Receiving Party and
reference the time and place of disclosure.

     2.  With respect to all Confidential Information furnished by the
Disclosing Party to the Receiving Party, the Receiving Party agrees that it
shall

         a.  maintain such Confidential Information in strict confidence;

         b.  not disclose or permit the disclosure of such Confidential
Information to any persons other than to persons who are obligated to maintain
the confidential nature of such Confidential Information and who need to know
such Confidential Information for the purposes set forth in the Sponsored
Research Agreement;

         c.  use such Confidential Information solely for the purpose set forth
in the Sponsored Research Agreement;

         d.  reproduce the Confidential Information only to the extent
necessary to effect the purposes set forth in the Sponsored Research Agreement,
with all such reproductions being considered Confidential Information.


     3.  The obligations of the Receiving Party under Section 2 above shall not
apply to the extent that the Receiving Party can demonstrate that certain
Confidential Information:
<PAGE>

         a.  was in the public domain prior to the time of its disclosure;

         b.  entered the public domain after the time of its disclosure through
means other than an unauthorized disclosure resulting from an act or omission by
the Receiving Party;

         c.  was independently developed or discovered by the Receiving Party
at any time, whether before or after the time of its disclosure under this
Agreement;

         d.  is or was disclosed to the Receiving Party at any time, whether
prior to or after the time of its disclosure under this Agreement, by a third
party having no fiduciary relationship with the Disclosing Party and having no
obligation of confidentiality with respect to such Confidential Information; or

         e.  is required to be disclosed to comply with applicable laws,
governmental regulations or court orders, provided that the Disclosing Party
receives prior written notice of such disclosure and that the Receiving Party
takes all reasonable and lawful actions to obtain confidential treatment for
such disclosure and, if possible, to avoid such disclosure.

     4.  The Receiving Party agrees that the Disclosing Party (or any third
party entrusting its own Confidential Information to the Disclosing Party) is
and shall remain the exclusive owner of the Confidential Information disclosed
by the Disclosing Party and all patent, copyright, trademark, trade secret, and
other intellectual property rights in such Confidential Information or arising
therefrom.  No option, license, or conveyance of such rights to the Receiving
Party is granted or implied under this Agreement.  If any such rights are to be
granted to the Receiving Party, such grant shall be expressly set forth in a
separate written instrument.

     5.  Upon the termination by either party of the Sponsored Research
Agreement, the Receiving Party shall return to the Disclosing Party all
originals, copies, and summaries of documents, materials, and other tangible
manifestations of Confidential Information in the possession or control of the
Receiving Party, except that the Receiving Party may retain one copy of such
information with its legal counsel solely for the purpose of documenting its
obligations under this Agreement.

Acknowledged and agreed:

SEQUENOM, INC.


By:_______________________________        _____________________________________
Name:                                     [Name of Investigator]
Title:
<PAGE>

                                   EXHIBIT C

                               PRIOR INVENTIONS


Exhibit C-1:      ***
- -----------

Exhibit C-2:      ***
- -----------




     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                                                     Exhibit C-1
                                                                     -----------

                                      ***
                                      ***
                                      ***
                                      ***
                                      ***
                                      ***
                                      ***




     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                                                     Exhibit C-2
                                                                     -----------


                                      ***
                                      ***
                                      ***
                                      ***
                                      ***
                                      ***
                                      ***



     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                   EXHIBIT D

                          TERMS OF LICENSE AGREEMENT


1.   The Agreement shall be subject to the Boston University Patent Policy,
     Charles River Campus, and to agreements with other sponsors of research
     that are promptly disclosed to SPONSOR.

2.   SPONSOR shall pay UNIVERSITY a royalty on net sales of chip-based products
     ("Licensed Products") as follows:

     a)  ***

     b)  ***

     c)  ***

     Such Licensed Products are intended to be the source of the nucleic acids
     used with the     ***      instrument.  To the extent that SPONSOR itself
     uses a Licensed Product after it becomes commercially available, SPONSOR
     shall treat such Licensed Product as sold at its fair market value.

3.   If SPONSOR must pay license fees or royalties to third parties on a
     Licensed Product, SPONSOR may credit against any amounts due UNIVERSITY a
     total of    ***     of such third-party payments, provided that in no
     event shall any payment otherwise due UNIVERSITY be reduced by more than
     ***

4.   Control over, and associated expenses for, the filing, prosecution, and
     maintenance of patents and patent applications relating to inventions
     licensed under Section 8.3(a) will be allocated as set forth in Section 8.2
     of the Sponsored Research Agreement.  Upon execution of a License
     Agreement, SPONSOR shall reimburse UNIVERSITY for reasonable expenses
     incurred in relation to the filing, prosecution, and maintenance of patents
     and patents applications relating to inventions licensed under Sections
     8.3(b) and 8.3(c).  In the event that UNIVERSITY obtains additional
     licensees under any invention licensed by SPONSOR, SPONSOR shall pay only
     its pro-rata share of patent-related expenses.  SPONSOR may credit against
     any amounts due UNIVERSITY a total of     ***     of expenses relating to
     patent filings, prosecution, and maintenance for the licensed invention(s),
     provided that in no event shall any payment otherwise due UNIVERSITY be
     reduced by more than     ***     SPONSOR shall have the right to cease
     paying for the filing, prosecution, or maintenance of any patent or patent
     applications in any country upon thirty (30) days prior written notice to
     UNIVERSITY.  In such event, SPONSOR will have no further rights under the
     Agreement with respect to such patents or patent applications in such
     country, and

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

     SPONSOR agrees to assign to UNIVERSITY any rights SPONSOR may have in such
     patents or patent applications in such country.

5.   SPONSOR shall have the right to prosecute any infringement of the licensed
     inventions, and to offset     ***     of the expenses incurred in such
     action against any amounts due UNIVERSITY, provided that in no event shall
     any payment otherwise due UNIVERSITY be reduced by more than      ***
     Any recovery obtained in such action shall be distributed in the following
     order of precedence: (1) UNIVERSITY will be reimbursed for any withheld
     payments, (2) SPONSOR will be reimbursed for its expenses, (3) UNIVERSITY
     will be paid a reasonable approximation of its royalty on lost sales of
     Licensed Products, and (4) SPONSOR will retain any remaining amounts except
     with respect to punitive or other extraordinary damages, which shall be
     distributed     ***    to SPONSOR and     ***     to UNIVERSITY.

6.   SPONSOR shall have the right to defend against any claim of infringement
     based on the exercise of its rights under the Agreement or any claim of
     invalidity or unenforceability of any patents covering the licensed
     inventions.  SPONSOR may offset     ***     of the expenses incurred in
     such action against any amounts due UNIVERSITY.  UNIVERSITY shall have the
     right, at its expense, to intervene and assume control of such action.
     SPONSOR may not settle such action without the consent of UNIVERSITY, which
     consent shall not be unreasonably withheld or delayed.

7.   UNIVERSITY and its affiliated hospitals shall retain a *** license, without
     the right to sublicense, to use the invention solely for noncommercial
     research purposes.

8.   If and to the extent applicable to the invention, the rights of the United
     States of America as set forth in Public Laws 96-517 and 98-620 (codified
     at 35 U.S.C. 200 et seq.) are specifically reserved, and SPONSOR shall
                      -- ---
     comply with the provisions of 35 U.S.C. 204, as amended from time to time.

9.   The Agreement shall provide for termination in the event that SPONSOR has
     not introduced Licensed Products into public use, or is not actively
     seeking to do so, within a reasonable time period.  SPONSOR shall have the
     right to terminate the Agreement for any reason upon written notice to
     UNIVERSITY.  Either party may terminate the Agreement with written notice
     in the event of a material breach by the other party.

10.  The Agreement shall provide for product liability indemnification and
     insurance requirements which are acceptable to the UNIVERSITY's Risk
     Management Office.

11.  Upon the expiration of the last to expire of the patents covering all
     licensed inventions, SPONSOR shall have a paid up license under the
     licensed inventions.



     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                   EXHIBIT E

                                 PATENT POLICY
<PAGE>

Boston University Patent Policy

CHARLES RIVER CAMPUS

_____________________________________________________________________________

PREAMBLE
The patent policy outlined herein is the Policy of the Trustees of Boston
University (the "University").  The University recognizes that patentable
inventions may be made in the course of research sponsored by the University
and/or by others through the University.  It is the policy of the University to
maximize the benefits to the individual who makes such patentable inventions, to
the University and to the general public, and thus to stimulate initiative in
the faculty, staff, and employees of the University.  The University recognizes
that this may best be accomplished through patenting and licensing such
inventions in a manner consistent with the public interest, and for such purpose
the University hereby establishes the patent policy set forth herein.  This
Policy supersedes all prior patent policies and amendments thereto applicable to
the Charles River Campus.

1.   PATENT POLICY

     A.  In order to protect the public good and the University, and in order to
fulfill obligations to research sponsors, the University shall claim equity in
all discoveries and its right to acquire the title to and control of such
discoveries where the discoveries are made by faculty, staff, employees, or
students (including all types of trainees or postgraduate fellows) working on or
arising from programs supported in whole or in part by funds, space, personnel,
or facilities provided by the University.


     B.  When a discovery is made by an inventor outside of any program
conducted by the University, and the inventor can demonstrate that the
University did not provide or administer significant funds, space, personnel, or
facilities for work leading to the discovery, the discovery shall remain the
exclusive property of the inventor or his/her sponsor.  The University shall not
ordinarily consider provision of office, classroom, or library facilities as
constituting significant use of University funds, space, personnel or
facilities.  For purposes of this Policy, the term "Investor" shall include all
individuals who participated in and signed a disclosure statement respecting a
discovery or invention.

     C.  When necessary, the University Committee on Inventions and Discoveries
("Committee") shall decide whether an invention or discovery should be
classified under Paragraph A or Paragraph 3 of this Paragraph 1.  Persons or
entities claiming a right to receive royalty interests under the provisions of
Paragraph 4 may appeal the decision of the Committee to the President of the
University.  The President shall recommend final action to the Trustees, whose
decision shall be final.

2.   ROYALTIES

Where the University is entitled to equity in a discovery, the Inventor shall
receive 30 percent of the net royalties accruing therefrom unless the University
recommends a lesser share, which shall not be less than 15 percent based upon
relevant circumstances relating to the discovery.  In the
<PAGE>

event that the University determines that such lesser share is appropriate, the
University shall in its sole discretion designate the recipient or recipients of
the percentage share by which the Investor's share has been reduced. The
Community Technology Foundation (CTF) of Boston University, exclusive agent for
the administration of patents or discoveries made within the University, shall
receive 45 percent of the net royalties (see Paragraph 4). The remaining
royalties from, and equities in the Invention shall be distributed to the School
of the Investor, or in the absence of a School's being involved, the primary
unit or entity of the University with which the Investor works or is affiliated.
Net royalties are defined as gross royalties less amounts granted by the
University specifically for the invention or discovery process, and the cost of
securing, protecting, preserving, and maintaining patents, and of licensing and
marketing of the patent rights, or other costs or fees directly attributable to
the inventions being licensed.

3.   DISCLOSURES

Because the securing of rights in discoveries and inventions depends on prompt
and efficient patent application and administration, all faculty, staff,
students, and employees of the University who make inventions or discoveries
shall immediately disclose said inventions or discoveries to the CTF Patent
Administrator and to the Investor's supervisor.  This disclosure obligation
shall apply to all inventions and discoveries, without regard to whether they
fail under Paragraph A or 3 above.

4.   PATENT ADMINISTRATION

CTF shall be the exclusive agent of the University for the administration of
inventions and discoveries made within the University and covered under
Paragraph 1.A.  CTF shall present the disclosures to the Committee.  Such report
shall state whether CTF has determined that an invention or discovery will be
developed by the University.  The Committee shall consist of eleven voting
members, at least a majority of whom shall be faculty members from the Schools
and Colleges of the University.  The members of the Committee and the Chairman
of the Committee shall be designated by the President of the University.  CTF
shall render a written semiannual report to the Chairman of the Committee on the
disposition and status of all inventions and discoveries submitted.  CTF shall
as promptly as practicable determine whether an invention or discovery shall be
pursued by the University.  If the Committee determines that CTF has not filed a
patent application within one year after it has received a disclosure in respect
of which the University is entitled to claim an interest, the Committee, in
consultation with the Inventor, shall determine what other disposition, if any,
shall be made of the invention or discovery and of its development.

5.   COVERAGE

The Policy shall cover only discoveries and inventions that are patentable as
the term is defined in the United States Code, as amended, or the laws of other
countries where applications are filed.

6.   TRUSTEE REVIEW
<PAGE>

Any disputes that arise under this Policy that are not resolved by the Committee
shall be referred to the President of the University, who shall recommend final
action to the Trustees.  The decision of the Trustees shall be final with
respect to all disputes.

7.   EMPLOYMENT AGREEMENTS

Rights and obligations under this Policy shall survive any termination of
enrollment or employment at the University.

     Nothing herein contained is intended to grant or dispose of any right,
title, and interest to any disclosure, idea, improvement, or invention, whether
patentable or not, which has been supported or funded by outside parties who
acquire rights to such disclosure, ideas, improvements, and invention.

7.   CONSULTING AGREEMENTS

The rights of the University under this policy, and the interests of sponsors
under research grants or contracts, may not be abrogated or limited by
consulting agreements or other contracts entered into between University
students or employees and outside organizations or employers.  University
students and employees should inform outside employers of their obligations and
commitments to the University under this policy.  Such students and employees
should ascertain that patent clauses in their agreements are not in conflict
with their obligations to the University or this Policy statement.  Each student
and employee should make his/her obligations to the University clear to those
with whom such agreements may be made, and should ensure that they are provided
with a current statement of University policy.  Upon request, the University
will provide a standard clause which may be inserted in a student's or
employee's consulting agreement.  This clause will put third parties on notice
as to the University's rights under this policy with respect to inventions and
discoveries.  In cases of conflict of interest, the University reserves the
ultimate right to determine the final disposition of the rights and interests
involved.


Adopted, as amended, by the Trustees of Boston University, November 12, 1991.


                               PATENT AGREEMENT

I affirm that I have received and have read the Boston University Patent Policy
Charles River Campus.

For and in consideration of the provision by Boston University or support in the
form of funds, space, personnel, facilities instruction, supervision or other
assistance, I hereby accept the aforesaid Patent Policy as determinative of my
rights are (_________) in relation to any discoveries or patentable inventions.

________________________________________________________________________________
     Signature                                                              Date

________________________________________________________________________________
Name
<PAGE>

Proposed Budget                                                          2/16/95
Sponsor:  SEQUENOM                            EXHIBIT F
                                              ---------
Principal Investigator: Dr. Charles Cantor
Project Duration 9/15/94 - 9/14/95

                                                 ***
                                                 ***
                                                 ***
                                                 ***
                                                 ***
                                                 ***
                                                 ***

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                              SEQUENOM, INC.
                                              11555 Sorrento Valley Road
                                              Suite C
                                              San Diego, California  92121



                                              February 5, 1997


Boston University
Attention: Maureen Rodgers
Office of Sponsored Programs
881 Commonwealth Avenue
Boston, Massachusetts  02215

Re:  Sponsored Research Agreement dated September 15, 1994 between the Trustees
     of Boston University and Sequenom, Inc. (the "Agreement")

Ladies/Gentlemen:

The purpose of this letter is to set forth our understanding with respect to the
termination of the Agreement and the final payment due to Boston University with
respect to the Agreement. We have agreed as follows:

1.   The Agreement shall be deemed to have been extended from September 15, 1995
     through September 30, 1997 under Article II thereof, and shall expire on
     September 30, 1997.

2.   In full satisfaction of all monetary obligations of Sequenom, Inc. to
     Boston University with respect to the Agreement as so extended, whether due
     or to become due, Sequenom shall make a final payment of     ***     to
     Boston University promptly following execution hereof by all parties
     hereto.  This will bring the total amount paid by Sequenom to Boston
     University under the Agreement to     ***.

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

Boston University
February 5, 1997
Page Two



If the foregoing correctly sets forth our understanding, please execute one copy
of this letter agreement in the space indicated below and return it to me at
your earliest convenience.


                                         Very truly yours,

                                         /s/ John J. DiBello

                                         John J. DiBello, CFO


Accepted and agreed this
11th day of February, 1997


TRUSTEES OF BOSTON UNIVERSITY                CHARLES R. CANTOR


By: /s/ John F. Imbergano                    /s/ Charles R. Cantor
- ---------------------------------------      ----------------------------------
       John F. Imbergano
       Asst. V.P. for Financial Affairs
       & Comptroller
<PAGE>

            Sequenom, Inc.            SEQUENOM LOGO         Sequenom GmbH
       11555 Sorrento Valley Road                      Mendelssohnstrasse 15 D
     San Diego, CA  92121-1331 USA                     D-22761 Hamburg Germany
             Tel. + 1-619-350-0345                       Tel. + 49-40-899676-0
             Fax. + 1-619-350-0344                       Fax. + 49-40-899676-0
               www.sequenom.com                           www.sequenom.com




September 6, 1998

Re: BU Sponsored Research Agreement

Dear Dr. Cantor:

Your request for a     ***     extension to the Sponsored Research Agreement is
granted.  Specifically, the end date is extended to 9/30/99 for completion of
the work plan as outlined in the current Sponsored Research Agreement between
Boston University and Sequenom Inc. (PI: Charles R. Cantor).  Sequenom, Inc.
will immediately pay the remaining funding of     ***     under this existing
agreement.

Sincerely,

/s/ Steve Zaniboni

Steve Zaniboni
Sr. Vice President
Finance and Administration



     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                                                   EXHIBIT 10.25

                     PATENT AND KNOW-HOW LICENSE AGREEMENT

     THIS PATENT AND KNOW-HOW LICENSE AGREEMENT (the "Agreement") dated as of
the 1st day of June, 1996 (the "Effective Date"), is made by and between the
TRUSTEES OF BOSTON UNIVERSITY (hereinafter referred to as "UNIVERSITY"), a
corporation duly organized and existing under the laws of the Commonwealth of
Massachusetts and having a principal office at 147 Bay State Road, Boston,
Massachusetts 02215, and Sequenom, Inc., a corporation organized under the laws
of Delaware, whose address is c/o Techno Venture Management, 101 Arch Street,
Suite 1950, Boston, Massachusetts 02110 (Sequenom, Inc. and any Affiliate of
Sequenom, Inc. hereinafter referred to as "LICENSEE").

                                  WITNESSETH:

     WHEREAS, UNIVERSITY and LICENSEE have entered into a certain Sponsored
Research Agreement, effective as of September 15, 1994 (the "Sponsored Research
Agreement"), pursuant to which UNIVERSITY granted to LICENSEE a first option to
acquire an ***, worldwide license to certain technology; and

     WHEREAS, UNIVERSITY and LICENSEE wish to set forth the terms of such
exclusive, worldwide license;

     NOW, THEREFORE, in consideration of the foregoing premises and the mutual
covenants herein contained, the parties hereby agree as follows:

                            ARTICLE I.  DEFINITIONS
                            -----------------------

     For purposes of the Agreement, the terms defined in this Article shall have
the respective meanings set forth below:

     1.1  "Affiliate" shall mean, with respect to any Person, any other Person
           ---------
which directly or indirectly controls, is controlled by, or is under common
control with, such Person. A Person shall be regarded as in control of another
Person if it directly or indirectly possesses the power to direct or cause the
direction of the management and policies of the other Person by any means
whatsoever.

     1.2  "Field" shall mean  ***   .
           -----

     1.3  "First Commercial Sale" shall mean, with respect to any Product, the
           ---------------------
first sale for use or consumption by the general public of such Product.

     1.4  "Net Income" shall mean all royalties actually received by LICENSEE
           ----------
from sublicensees with respect to Products and all sublicense fees (including
technology access fees, license issue fees, and license maintenance fees, but
excluding payments in connection with the issuance of debt or securities by
LICENSEE) actually received by LICENSEE relating solely to sublicenses of
University Patent Rights or University Know-How, in each case that do not

     *** Portions of this page have been omitted pursuant to confidential
treatment request and filed separately with the Commission.

<PAGE>

involve Net Sales of Products by LICENSEE, less all costs, expenses and
disbursements incurred by LICENSEE in connection therewith, including, without
limitation, all legal and accounting fees associated with the preparation,
negotiation and implementation of any such sublicense agreements.

     1.5  "Net Sales" shall mean the gross amount billed or invoiced on sales
           ---------
by LICENSEE of Products, less the following: (i) trade, quantity, or cash
discounts to the extent actually allowed and taken; (ii) amounts repaid or
credited by reason of rejection or return; and (iii) any taxes, imposts,
tariffs, custom duties or other governmental charges levied on the production,
sale, transportation, delivery, or use of a Product which are paid by or on
behalf of Company.

     1.6  "Person" shall mean an individual, corporation, partnership, trust,
           ------
business trust, association, joint stock company, limited liability company,
limited liability partnership, joint venture, pool, syndicate, sole
proprietorship, unincorporated organization, governmental authority or any other
form of entity not specifically listed herein.

     1.7  "Product" shall mean any product which if made, used or sold would
           -------
infringe one or more Valid Patent Claims in an issued patent but for the license
granted by the Agreement, or which otherwise uses, incorporates or was
conceived, developed or reduced to practice using the UNIVERSITY Patent Rights
or UNIVERSITY Know-How.

     1.8  "Territory"' shall mean all jurisdictions worldwide.
           ----------

     1.9  "Third Party" shall mean any Person other than UNIVERSITY, LICENSEE
           -----------
and their respective Affiliates.

     1.10  UNIVERSITY Improvements" shall mean all inventions, discoveries,
           -----------------------
processes, methods, compositions, formulae, procedures, protocols, software
developments and improvements, techniques, results of experimentation and
testing, information and data, which have been conceived by employees or others
acting on behalf of UNIVERSITY, either alone or jointly with others, as of the
Effective Date of the Agreement, or which are conceived by employees or others
acting on behalf of UNIVERSITY, either alone or jointly with others, during any
Research Program under the Sponsored Research Agreement, and which constitute
improvements to the UNIVERSITY Patent Rights or UNIVERSITY Know-How or are
conceived, developed or reduced to practice using the UNIVERSITY Patent Rights
or UNIVERSITY Know-How.

     1.11 "UNIVERSITY Know-How" shall mean all inventions, discoveries,
           -------------------
processes, methods, compositions, formulae, procedures, protocols, software
developments and improvements, techniques, results of experimentation and
testing, information and data, which are not generally known, (i) embodying or
produced through use of UNIVERSITY Patent Rights and associated know-how, or
(ii) embodying or produced through inventions conceived, discovered or reduced
to practice, whether alone or with others, by UNIVERSITY employees or with
UNIVERSITY facilities or equipment, in the course of any Research Program under
the Sponsored Research Agreement, or (iii) otherwise regarding the Field, in
which UNIVERSITY

                                                                  -Page 2 of 23-
<PAGE>

has an ownership or other interest during the term of this Agreement; all to the
extent and only to the extent that UNIVERSITY has the right to grant licenses or
other rights thereunder.

     1.12  "UNIVERSITY Patent Rights" shall mean (a)              ***
            --------------------------
and all patent applications, heretofore or hereafter filed or having legal force
in any country within the Territory, embodying or produced through inventions
conceived, discovered or reduced to practice, whether alone or with others, by
UNIVERSITY employees or with UNIVERSITY facilities or equipment, in the course
of any Research Program under the Sponsored Research Agreement, or otherwise
regarding analysis, sequencing and detection of nucleic acids using mass
spectrometry, which claim an invention in which UNIVERSITY has an ownership or
other interest during the term of this Agreement, (b) all patents that have
issued or in the future issue from the patent applications described in clause
(a) above, including utility, model and design patents and certificates of
invention, and (c) all divisions, continuations, continuations-in-part which are
directed to subject matter specifically described in the U.S. Patents and Patent
Applications listed above, reissues, renewals, extensions or additions to any
such patent applications and patents, and any UNIVERSITY Improvements thereto
upon which a patent application has been filed or a patent has issued. A list of
the UNIVERSITY Patent Rights as of the date of the Agreement is attached hereto
as Exhibit A.

     1.13  "Valid Patent Claim" shall mean a claim of an issued and
            ------------------
unexpired patent included within the UNIVERSITY Patent Rights that has not been
held permanently revoked, unenforceable or invalid by a decision of a court or
other governmental agency of competent jurisdiction, which decision is
unappealable or has not been appealed within the time allowed for appeal, and
that has not been admitted to be invalid or unenforceable through reissue or
disclaimer or otherwise.

                  ARTICLE II. REPRESENTATIONS AND WARRANTIES
                  ------------------------------------------

     Each party hereby represents and warrants to the other party as follows:

     2.1   Existence and Power.  Such party (a) is duly organized, validly
           -------------------
existing and in good standing under the laws of the jurisdiction in which it is
incorporated and (b) has the power and authority and the legal right to own and
operate its property and assets, to lease the property and assets it operates
under lease, and to carry on its business as it is now being conducted.

     2.2   Authorization and Enforcement of Obligations.  Such party (a) has the
           --------------------------------------------
power and authority and the legal right to enter into this Agreement and to
perform its obligations hereunder and (b) has taken all necessary action on its
part to authorize the execution and delivery of this Agreement and the
performance of its obligations hereunder. This Agreement has been duly

                                                                  -Page 3 of 23-

     *** Portions of this page have been omitted pursuant to confidential
treatment request and filed separately with the Commission.

<PAGE>

executed and delivered on behalf of such party and constitutes a legal, valid
and binding obligation of such party, enforceable against such party in
accordance with its terms.

     2.3  No Consents.  To the knowledge of such party and subject to the rights
          -----------
of the United States government set forth in the Bayh-Dole Act, 35 U.S.C. (S)
200 et seq. (1980), all necessary consents, approvals and authorizations of all
governmental authorities and other Persons required to be obtained by such party
in connection with this Agreement have been obtained.

     2.4  No Conflict.  The execution and delivery of this Agreement and the
          -----------
performance of such party's obligations hereunder (a) to the knowledge of such
party and subject to the rights of the United States government set forth in the
Bayh-Dole Act, 35 U.S.C. (S) 200 et seq. (1980), do not conflict with or violate
any requirement of applicable laws or regulations, and (b) do not conflict with,
or constitute a default under, any contractual obligation of it.

     2.5  University Representations and Warranties.  UNIVERSITY hereby
          -----------------------------------------
represents and warrants to LICENSEE as follows:

          (a)  Validity and Enforceability of UNIVERSITY Patent Rights.  To the
               -------------------------------------------------------
knowledge of UNIVERSITY, every claim of the patents listed on Exhibit A attached
hereto is valid and enforceable, and every claim of the patent applications
listed on such Exhibit A, is valid and, if issued, shall be enforceable.

          (b)  Third Party Claims.  No claim has been made by, and to the
               ------------------
knowledge of UNIVERSITY no claim is available to, any Third Party that any
activity permitted by the licenses granted to LICENSEE pursuant to this
Agreement constitutes an infringement of any right of any such Third Party
anywhere in the world, including, without limitation, any right under any
copyright, trademark, trade secret, patent, or other proprietary right of any
such Third Party.

          (c)  Patent Documents. UNIVERSITY has provided LICENSEE with copies of
               ----------------
all documents relevant to the validity or enforceability of the University
Patent Rights, including, without limitation, copies of all patent searches and
legal opinion letters relating to any patents included within the University
Patent Rights and copies of all documents relating to any infringement of the
University Patent Rights.

     2.6  Warranty Disclaimer.  EXCEPT AS SET FORTH IN THIS SECTION 2,
          -------------------
UNIVERSITY MAKES NO WARRANTY, EXPRESS OR IMPLIED, INCLUDING, WITHOUT LIMITATION,
ANY IMPLIED WARRANTIES OF MERCHANTABILITY, OF NON-INFRINGEMENT, OF SCOPE OF
PATENT RIGHTS, OR OF FITNESS FOR A PARTICULAR PURPOSE, WITH RESPECT TO ANY
PATENT, TRADEMARK, SOFTWARE, NON-PUBLIC OR OTHER INFORMATION, OR TANGIBLE
RESEARCH PROPERTY, LICENSED OR OTHERWISE PROVIDED TO LICENSEE HEREUNDER AND
HEREBY DISCLAIMS THE SAME.

                                                                  -Page 4 of 23-
<PAGE>

                          ARTICLE III.  LICENSE GRANT
                          ---------------------------

     3.1  License Grant to LICENSEE.  UNIVERSITY hereby grants to LICENSEE an
          -------------------------
***    license, including the right to grant sublicenses, under the UNIVERSITY
Patent Rights and UNIVERSITY Know-How to develop, make, have made, use, sell,
license, market and otherwise exploit Products in the Territory. Except as set
forth in Section 3.2 of this Agreement, such license shall be *** as to
UNIVERSITY. Such license shall be limited to the Field with respect to the
inventions set forth on Exhibit C-I to the Sponsored Research Agreement;
otherwise, such license shall be valid with respect to any field.

     3.2  Reservation of Certain Rights.  Notwithstanding the foregoing, the
          -----------------------------
license granted to LICENSEE by the Agreement is subject to the reservation of
(a) a *** license, *** for UNIVERSITY and its affiliated hospitals to use the
inventions claimed by the UNIVERSITY Patent Rights solely for *** purposes and
(b) if and to the extent applicable, the rights of the United States of America
as set forth in Public Laws 96-517 and 98-620 (codified at 35 U.S.C. 200 et.
                                                                         --
seq.).
- ---

LICENSEE shall comply with the provisions of 35 U.S. C. 204, as amended from
time to time. The Parties shall comply with all applicable United States and
foreign laws and regulations, and nothing in this Agreement shall require or be
construed to require either Party to violate such provisions of law or subject
either Party to liability for adhering to such provisions of law.

     3.3  Technical Assistance.
          --------------------

          (a)  Upon execution of the Agreement, UNIVERSITY shall disclose and
make available to LICENSEE all information available to UNIVERSITY and not
previously disclosed to LICENSEE regarding the use of the UNIVERSITY Patent
Rights and UNIVERSITY Know-How.

          (b)  During the term of the Agreement, upon reasonable notice, during
normal business hours and after agreement on anticipated costs, UNIVERSITY (a)
shall provide such technical assistance regarding the UNIVERSITY Patent Rights
and UNIVERSITY Know-How as LICENSEE reasonably requests to conduct its
activities contemplated by the Agreement, (b) shall make available to LICENSEE
such technical personnel of UNIVERSITY as reasonably necessary to provide the
foregoing technical assistance, and (c) shall disclose and make available to
LICENSEE all information available to UNIVERSITY and not previously disclosed to
LICENSEE regarding the use of the UNIVERSITY Patent Rights and UNIVERSITY Know-
How. LICENSEE shall reimburse UNIVERSITY for research or consulting costs agreed
by the parties for any such technical assistance, together with such reasonable
out-of-pocket travel and other expenses incurred by UNIVERSITY in providing such
technical assistance as are approved in advance by LICENSEE. UNIVERSITY shall
provide LICENSEE with estimates of the anticipated costs of any requested
technical assistance prior to undertaking such technical assistance.

     3.4  Exclusivity of Sublicenses.  LICENSEE hereby agrees that every
          --------------------------
sublicensing agreement to which it shall be a party and which shall relate to
the rights, privileges and license

                                                                  -Page 5 of 23-

     *** Portions of this page have been omitted pursuant to confidential
treatment request and filed separately with the Commission.

<PAGE>

granted hereunder shall contain a statement describing the conditions under
which LICENSEE'S exclusive rights, privileges and license hereunder may
terminate.

     3.5  Copies of Sublicenses.  LICENSEE shall furnish to UNIVERSITY a true
          ---------------------
and complete copy of each sublicense agreement and each amendment thereto,
promptly after the sublicense or amendment has been executed. Each such
sublicense agreement or amendment shall constitute Confidential Information of
LICENSEE.

     3.6  Obligations of Sublicensees.  LICENSEE agrees that any sublicenses
          ---------------------------
granted by it shall not be inconsistent with this Agreement and shall contain
provisions comparable to the provisions of this Agreement with respect to
confidentiality.

     3.7  Limitation on Rights.  The license granted hereunder shall not be
          --------------------
construed to confer any rights upon LICENSEE by implication, estoppel or
otherwise as to any technology not specifically licensed hereunder.

                          ARTICLE IV.  DUE DILIGENCE
                          --------------------------

     4.1  LICENSEE agrees to use commercially reasonable efforts to effect
introduction of the use of the Products into the United States commercial market
as soon as practical, consistent with sound and reasonable business practices
and judgments.

     4.2  LICENSEE acknowledges that UNIVERSITY shall be permitted to review any
business plan of LICENSEE that LICENSEE has provided to UNIVERSITY's Community
Technology Fund ("CTF") from time to time, and LICENSEE hereby authorizes CTF to
release any such business plan to UNIVERSITY. UNIVERSITY shall have the right to
render non-exclusive the license granted under Section 3 of this Agreement,
solely with respect to any particular "subject inventions," as defined in the
Bayh-Dole Act, 35 U.S.C. 201(e) (1980), within the UNIVERSITY Patent Rights, if
and only if: (i) at any time after four (4) years after the Effective Date,
within ninety (90) days after written notice from UNIVERSITY to LICENSEE of
UNIVERSITY's intent to render such license ***, LICENSEE has not put the subject
inventions into commercial use and is not keeping such subject inventions
reasonably available to the public; (ii) LICENSEE is not demonstrably engaged in
a significant research, development, manufacturing, marketing or licensing
program with respect to such subject inventions; and (iii) such failure does not
result from actions or inactions of any agency whose approval is required for
commercial sales. At any time after seven (7) years after the Effective Date,
UNIVERSITY shall have the right to terminate the license granted under Section 3
of this Agreement, solely with respect to any such "subject inventions," if and
only if the conditions set forth in sub-paragraphs (ii) and (iii) in the
preceding sentence are met and, within ninety (90) days after written notice
from UNIVERSITY to LICENSEE of UNIVERSITY's intent to terminate such license,
LICENSEE has not put such subject inventions into commercial use and is not
keeping such subject inventions reasonably available to the public. If
UNIVERSITY elects to terminate such license with respect to particular subject
inventions, the UNIVERSITY shall refund to LICENSEE that portion of the funds
provided to UNIVERSITY by LICENSEE under the Sponsored Research Agreement that
related to the development of such subject
                                                                  -Page 6 of 23-


     *** Portions of this page have been omitted pursuant to confidential
treatment request and filed separately with the Commission.

<PAGE>

inventions. UNIVERSITY's rights under this Section 4.2 shall be UNIVERSITY's
sole remedy for failure by LICENSEE to put Products to commercial use or to make
Products available to the public. Without limiting the generality of the
foregoing, failure by LICENSEE to put Products to commercial use or to make
Products available to the public shall not constitute a ground for UNIVERSITY to
terminate this Agreement under Section 9.4 hereof.

                              ARTICLE V. PAYMENTS
                              -------------------

     5.1  Royalties.        ***
          ---------

          (a)       ***

          (b)       ***

          (c)       ***

     5.2  Payments. All royalties pursuant to Section 5.1 shall accrue on the
          --------
date on which LICENSEE actually receives payment with respect to Net Sales of
particular Products or with respect to particular Net Income. All royalties
pursuant to Section 5.1 shall be paid on a quarterly basis, within 60 days
following the end of the quarter in which they accrued. Each payment shall be
accompanied by a report setting forth the calculation of the amount due. All
monies to be paid to UNIVERSITY shall be made and computed in United States
Dollars, and LICENSEE shall use its best efforts to convert royalties in any
country to United States Dollars; provided, however, that if conversion to and
transfer of Dollars cannot be made by LICENSEE in any country for any reason,
LICENSEE may pay such sums in the currency of the country in which Net Sales are
made or Net Income is paid to LICENSEE, deposited in UNIVERSITY's name, in a
bank designated by UNIVERSITY in any such country. The rate of exchange of local
currencies to United States Dollars shall be the rate of exchange prevailing at
the Bank of Boston on the day such payment is made pursuant to the periods set
forth in this Section 5.2.

     5.3  Reports. Within sixty (60) days after March 31, June 30, September 30
          -------
and December 31 of each year in which this Agreement is in effect, LICENSEE
shall deliver to UNIVERSITY full, true and accurate reports of its activities
relating to this Agreement during the preceding three month period. These
reports shall include at least the following:

          (a)  amount of Net Sales for period;

          (b)  deductions applicable to a determination of Net Sales;

                                                                  -Page 7 of 23-

     *** Portions of this page have been omitted pursuant to confidential
treatment request and filed separately with the Commission.

<PAGE>

          (c)  amount of Net Income received from sublicensees;

          (d)  deductions applicable to a determination of Net Income;

          (e)  total royalties due; and

          (f)  activities of LICENSEE directed toward promoting the sale and use
of Products.

     5.4  Records. LICENSEE shall keep (or cause to be kept) and maintain
          -------
complete and accurate records of its sales of the Products in accordance with
generally accepted accounting principles. Such records shall be accessible to an
authorized representative selected and paid for by UNIVERSITY and acceptable to
LICENSEE, not more than once a year at any reasonable time during business hours
until three (3) years after the end of the royalty period to which such records
relate, for the purpose of verifying NET SALES and any royalty due thereon. Such
representative shall disclose to UNIVERSITY only information relating to the
accuracy of the records kept and the payments made, and shall be under a duty to
keep confidential any other information gleaned from such records. Any
adjustment in the amount of royalties due the UNIVERSITY on account of
overpayment or underpayment of royalties shall be made at the next date when
royalty payments are to be made to the UNIVERSITY under Section 5.2 herein. If
the verification on behalf of the UNIVERSITY results in an upward adjustment of
greater than ten percent (10%) of royalties due to the UNIVERSITY for the period
of time in question, LICENSEE shall pay the out-of-pocket expenses of the
UNIVERSITY relating to such verification.

     5.5  Credits.
          -------

          (a)  If LICENSEE must pay license fees or royalties to Third Parties
on a Product, LICENSEE may credit against any amounts due UNIVERSITY a total of
*** of such payments to Third Parties; provided, however, that any payment
otherwise due UNIVERSITY shall not be reduced by more than ***. In addition, and
notwithstanding, the last clause of the preceding sentence, in the event that
the license fees and royalties payable hereunder and to Third Parties on a
Product exceed *** of the Net Sales price of such Product in any jurisdiction or
*** of LICENSEE's Net Income with respect to sublicenses in such jurisdiction,
LICENSEE may reduce any amounts due UNIVERSITY hereunder pro rata with the
license fees and royalties due Third Parties on such Product, to the extent
necessary to reduce the total license fees and royalties for such Product to ***
of the Net Sales price of the Product or *** of LICENSEE'S Net Income in such
jurisdiction.

          (b)  LICENSEE may credit against any amounts due UNIVERSITY under this
Agreement a total of *** of expenses relating to patent filings, prosecution,
and maintenance for the licensed invention(s).

          (c)  The amounts credited pursuant to this Section 5.5 are in addition
to any credit or offset permitted pursuant to Section 6.2 hereof.

                                                                  -Page 8 of 23-

     *** Portions of this page have been omitted pursuant to confidential
treatment request and filed separately with the Commission.

<PAGE>

     5.6  Late Payments. In the event that any payment due hereunder is not
          -------------
made when due, the payment shall accrue interest beginning on due date as herein
specified, calculated at the annual rate of the prime interest rate quoted by
the Bank of Boston on the date said payment is due, the interest being
compounded on the last day of each calendar quarter, provided that in no event
shall said annual rate exceed the maximum legal interest rate in Massachusetts.
The payment of such interest shall not foreclose UNIVERSITY from exercising any
other rights it may have as a consequence of any overdue payment.

                       ARTICLE VI. INFRINGEMENT ACTIONS
                       --------------------------------

     6.1  Enforcement of UNIVERSITY Patent Rights. UNIVERSITY shall notify
          ---------------------------------------
LICENSEE of any infringement in the Territory known to UNIVERSITY of the
UNIVERSITY Patent Rights and shall provide LICENSEE with the available evidence,
if any, of such infringement. LICENSEE, at its sole expense, shall have the
right to determine the appropriate course of action to enforce the UNIVERSITY
Patent Rights or otherwise abate the infringement thereof, to take (or refrain
from taking) appropriate action to enforce the UNIVERSITY Patent Rights, to
control any litigation or other enforcement action and to enter into, or permit,
the settlement of any such litigation or other enforcement action with respect
to the UNIVERSITY Patent Rights, and shall consider, in good faith, the
interests of UNIVERSITY in so doing. The parties may agree to permit UNIVERSITY
to control any such enforcement action. The party controlling any enforcement
action shall not settle the action or otherwise consent to judgment in such
action that adversely affects the rights or interests of the non-controlling
party or imposes additional obligations on the non-controlling party, without
the prior written consent of the non-controlling party. The party controlling
any enforcement action shall pay all expenses associated with such action;
provided, however, that LICENSEE may offset fifty percent (50%) of the expenses
incurred in any such action against any amounts due UNIVERSITY, provided that in
no event shall any payment otherwise due UNIVERSITY be reduced for such purpose
by more than fifty percent (50%). Any recovery obtained in such action shall be
distributed in the following order of precedence: (1) UNIVERSITY will be
reimbursed for any withheld payments, (2) LICENSEE will be reimbursed for its
expenses, (3) UNIVERSITY will be paid a reasonable approximation of its royalty
on lost sales of Products, and (4) LICENSEE will retain any remaining amounts
except with respect to punitive or other exemplary damages, which shall be
distributed seventy percent (70%) to LICENSEE and thirty percent (30%) to
UNIVERSITY.

     6.2  Abandonment of Suit. Should either party commence a suit under these
          -------------------
provisions and thereafter elect to abandon the same, it shall give timely notice
to the other party who, if it so desires, may continue prosecution of such suit;
provided, however, that the sharing of expenses and any recovery in such suit
shall be as agreed upon between the parties.

     6.3  Allegations of Invalidity or Non-Infringement. In the event any claim
          ---------------------------------------------
or action alleging invalidity or non-infringement of any of the UNIVERSITY
Patent Rights is brought against LICENSEE and/or UNIVERSITY, LICENSEE shall have
the right to control the defense and settlement of the action, provided that
payment of the expenses and costs of such action, including attorneys' fees,
shall be borne and reimbursed as set forth in Section 6. 1.

                                                                  -Page 9 of 23-
<PAGE>

     6.4  Cooperation. In any infringement suit as either party may institute
          -----------
to enforce the UNIVERSITY Patent Rights pursuant to this Agreement, the other
party hereto agrees, at the request and expense of the party initiating the
suit, to use its best efforts to cooperate, to have its employees testify when
requested and to make available relevant records, papers, information, samples,
specimens, and the like.

     6.5  Consent to Settlement. No settlement or consent judgment or other
          ---------------------
voluntary and final disposition of any suit affecting the UNIVERSITY Patent
Rights may be entered into without the consent of both parties, which consent
shall not be unreasonably withheld. Notwithstanding the foregoing, the party
controlling any suit referred to in this Article VI shall have the right to
settle any claims for infringement upon such terms and conditions that shall be
mutually agreed upon by UNIVERSITY and LICENSEE. During the term of this
Agreement, and upon the consent of UNIVERSITY, LICENSEE shall have the right to
sublicense any alleged infringer under the UNIVERSITY Patent Rights.

                         ARTICLE VII. CONFIDENTIALITY
                         ----------------------------

     7.1  Confidential Information. Each party shall exercise reasonable care
          ------------------------
to maintain in confidence all information of the other party (including samples)
disclosed by the other party and identified as, or acknowledged to be,
confidential (the "Confidential Information"), and shall not use, disclose or
grant the use of the Confidential Information except on a need-to-know basis to
those directors, officers, employees, agents, permitted sublicensees and
permitted assignees, to the extent such disclosure is reasonably necessary in
connection with such party's activities as authorized under this Agreement. Each
party shall notify the other promptly upon discovery of any unauthorized use or
disclosure of the other party's Confidential Information.

     7.2  Permitted Disclosures. The nonuse and nondisclosure obligations
          ---------------------
contained in this Article shall not apply to the extent that (a) any receiving
party (the "Recipient") is required (i) to disclose information by law, order or
regulation of a governmental agency or a court of competent jurisdiction, or
(ii) to disclose information to any governmental agency for purposes of
obtaining approval to test or market a product or to apply for a patent on any
UNIVERSITY Improvement, provided that the Recipient shall provide written notice
thereof to the other party and sufficient opportunity to object, time
permitting, to any such disclosure or to request confidential treatment thereof;
or (b) the Recipient can demonstrate that (i) the information was public
knowledge at the time of such disclosure by the Recipient, or thereafter became
public knowledge, other than as a result of acts attributable to the Recipient
in violation hereof-, (ii) the information was rightfully known by the Recipient
(as shown by its written records) prior to the date of disclosure to the
Recipient by the other party hereunder; (iii) the information was disclosed to
the Recipient on an unrestricted basis by a Third Party not under a duty of
confidentiality to the other party; or (iv) the information was independently
developed by employees or agents of the Recipient without access to the
Confidential Information of the other party.

                                                                 -Page 10 of 23-
<PAGE>

                     ARTICLE VIII. INVENTIONS AND PATENTS
                     ------------------------------------

     8.1  Ownership of Inventions. Ownership of UNIVERSITY Patent Rights and
          -----------------------
UNIVERSITY Know-How developed by individuals providing technical assistance on
behalf of UNIVERSITY pursuant to this Agreement shall be governed as if such
UNIVERSITY Patent Rights and UNIVERSITY Know-How were developed pursuant to the
Sponsored Research Agreement.

     8.2  Patent Rights Generally. Control over, and associated expenses for,
          -----------------------
the filing, prosecution, and maintenance of patents and patent applications
relating to inventions licensed hereunder will be allocated according to Section
8.2 of the Sponsored Research Agreement. In the event that UNIVERSITY obtains
additional licensees under any invention licensed by LICENSEE, LICENSEE shall
pay only its pro rata share of patent-related expenses. LICENSEE shall have the
right to cease paying for the filing, prosecution, or maintenance of any patent
or patent application in any country upon thirty (30) days prior written notice
to UNIVERSITY. In such event, LICENSEE will have no further rights under this
Agreement with respect to such patent or patent application in such country, and
LICENSEE agrees to assign to UNIVERSITY any rights LICENSEE may have in such
patent or patent application in such country.

     8.3  Reimbursement of Expenses. LICENSEE shall reimburse UNIVERSITY for
          -------------------------
the reasonable expenses incurred by UNIVERSITY in relation to the filing,
prosecution, and maintenance of patents and patents applications licensed
hereunder; provided, however, that such expenses shall be equally divided among
LICENSEE and any other licensees of the UNIVERSITY Patent Rights or the
UNIVERSITY Know-How.

                       ARTICLE IX. TERM AND TERMINATION
                       --------------------------------

     9.1  Term. This Agreement shall expire upon the expiration of the last to
          ----
expire patent included with the UNIVERSITY Patent Rights.

     9.2  Termination by UNIVERSITY. UNIVERSITY's right to terminate the
          -------------------------
license set forth in Section 3 of this Agreement shall be as set forth in
Section 4.2.

     9.3  Termination by LICENSEE. LICENSEE may terminate the Agreement,
          -----------------------
in its sole discretion, upon written notice to UNIVERSITY.

     9.4  Termination for Cause. Except as otherwise provided in the
          ---------------------
Article below regarding force majeure, either party may terminate the Agreement
upon or after the breach of any material provision of the Agreement by the other
party, if the other party has not cured such breach within sixty (60) days after
written notice thereof by the non-breaching party.

     9.5  Effect of Expiration or Termination. Expiration or termination
          -----------------------------------
of the Agreement shall not relieve the parties of any obligation accruing prior
to such expiration or termination, and the provisions of Articles VI, VII, X and
XIII shall survive the expiration or termination of the Agreement. The effect of
termination by UNIVERSITY pursuant to Section 4.2 shall be as set forth therein.
Upon expiration of the Agreement under Section 9.1 above,


                                                                 -Page 11 of 23-
<PAGE>

LICENSEE shall have a fully-paid, non-exclusive license to make, have made, use,
sell, license, market and otherwise exploit Products in the Territory.

             ARTICLE X.  INDEMNIFICATION; INSURANCE; AND LIABILITY
             -----------------------------------------------------

     10.1  Compliance with Government Regulations. The parties agree to
           --------------------------------------
comply with all regulations and safety standards of government agencies such as
the FDA.

     10.2  Indemnification. LICENSEE shall defend, indemnify and hold
           ---------------
harmless UNIVERSITY, and its trustees, officers, employees and agents and their
respective successors, heirs and assigns (the "Indemnitees"), against any and
all liability, damage, loss or expense (including reasonable attorneys' fees and
expenses of litigation) that may be incurred by or imposed upon the Indemnitees,
or any of them, in connection with any Third Party claim, suit, demand, action
or judgment arising out of the following:

          (a)  the design, production, manufacture, sale, use in commerce, lease
or promotion by LICENSEE or by an Affiliate or sublicensee of LICENSEE of any
product, process or service relating to or developed pursuant to this Agreement;
or

          (b)  any other activities of LICENSEE or a sublicensee to be carried
out pursuant to this Agreement.

LICENSEE'S indemnity under (a) shall apply to any liability, damage, loss or
expense whether or not it is attributable to the negligent activities of the
Indemnitees, and "Third-Party" claims under (a) shall be deemed to include
LICENSEE'S cross-claims and Third-Party complaints against Indemnitees arising
out of the matters described in (a) to the extent they are based on Third-Party
claims against LICENSEE arising out of such matters. LICENSEE'S indemnification
under (b) shall not apply to any liability, damage, loss or expense to the
extent that it is attributable to the negligence or willful misconduct of the
Indemnitees.

     10.3  Indemnification Procedure. A party (the "Indemnitee") that intends to
           -------------------------
claim indemnification under this article shall promptly notify LICENSEE of any
loss, liability, damage or expense, or any claim, demand, action or other
proceeding with respect to which the Indemnitee intends to claim such
indemnification, and the Indemnitee shall provide LICENSEE with the sole control
of the defense or settlement of any such claim, demand, action or other
proceeding. LICENSEE's indemnity obligations under this article shall not apply
to amounts paid in any settlement if effected without its consent. LICENSEE
shall not settle or consent to an adverse judgment in any such claim, demand,
action or other proceeding that directly affects the rights or interests of any
Indemnitee or imposes additional obligations on such Indemnitee, without the
prior express written consent of such Indemnitee, which consent shall not be
unreasonably withheld or delayed. The Indemnitee, its employees and agents,
shall cooperate fully with LICENSEE and its legal representatives in the
investigation of any action, claim or liability covered by this indemnification.

     10.4  Liability Insurance. At such time as any product, process or service
           -------------------
relating to, or developed pursuant to, this Agreement is being commercially
distributed or sold (other than for

                                                                 -Page 12 of 23-
<PAGE>

the purpose of obtaining regulatory approvals) by LICENSEE or a sublicensee,
LICENSEE shall at its sole expense, procure and maintain policies of
comprehensive general liability insurance in amounts not less than ***
per incident and *** in annual aggregate and naming the Indemnitees as
additional insureds. Such comprehensive general liability insurance shall
provide product liability coverage. LICENSEE shall provide UNIVERSITY with
written evidence of such insurance upon request of UNIVERSITY. In the event the
product liability coverage aforesaid is not occurrence liability, LICENSEE shall
maintain such comprehensive general liability insurance for a reasonable period
of not less than five (5) years after it has ceased commercial distribution or
use of any product, process or service relating to, or developed pursuant to,
this Agreement. If LICENSEE is unable to obtain the required amounts of
insurance at commercially reasonable rates, UNIVERSITY will cooperate with
LICENSEE to either obtain a waiver of this provision, assist in identifying a
carrier to provide such insurance, or identify a program for self-insurance or
other alternative measures. This Section 10.4 shall survive the expiration or
termination of this Agreement. Upon request, LICENSEE shall provide UNIVERSITY
with certificates of insurance evidencing its compliance with the insurance
requirements of this Section.

     10.5  Additional Limitations of Liability. Notwithstanding the provisions
           -----------------------------------
Section 2.3, the liability of UNIVERSITY of for any and all breaches of this
Agreement by a party other than UNIVERSITY, and for any and all failures of
Products in the aggregate, shall be limited to *** of the cumulative royalties
paid by LICENSEE, and LICENSEE hereby waives and disclaims the right to recover
any damages in excess of such amount for any and all such breaches and for any
and all such failures irrespective of whether such damages are direct, indirect,
consequential, incidental, or any other types of damages and irrespective of
whether based upon loss of investment, loss of production, lost profits,
interest on investment, interruption of business, or any other loss of any
character whatsoever. LICENSEE further agrees that its sole and exclusive remedy
for any and all such breaches and any and all such failures shall be to recover
damages actually sustained up to, and not in excess of, such amount. The
foregoing notwithstanding, nothing in this Agreement shall limit LICENSEE'S
right to seek equitable relief in the event of University's breach of Article
VII or Article II of this Agreement.

     10.6  Limited Liability. In no event shall either party be liable to
           -----------------
the other or any third party for any special, consequential or incidental
damages arising out of or related to this Agreement or with respect to any
claim, demand, action or other proceeding relating to this Agreement however
caused, and on any theory of liability (including negligence), whether or not
the party has been advised of the possibility of such damages.

                          ARTICLE XI.  FORCE MAJEURE
                          --------------------------

     Neither party shall be held liable or responsible to the other party nor be
deemed to have defaulted under or breached the Agreement for failure or delay in
fulfilling or performing any term of this Agreement to the extent, and for so
long as, such failure or delay is caused by or results from causes beyond the
reasonable control of the affected party including but not limited to from,
earthquakes, floods, embargoes, wars, acts of war (whether war is declared or
not),

                                                                 -Page 13 of 23-

     *** Portions of this page have been omitted pursuant to confidential
treatment request and filed separately with the Commission.

<PAGE>

insurrections, riots, civil commotions, strikes, lockouts or other labor
disturbances, acts of God or acts, omissions or delays in acting by any
governmental authority or other party.

                       ARTICLE XII.  DISPUTE RESOLUTION
                       --------------------------------

     12.1  Forum.  Any claim or controversy arising out of or relating to
           -----
this Agreement may be resolved by a court of competent jurisdiction located in
Boston, Massachusetts.

     12.2  Injunctive Relief.  Each party acknowledges that a breach by the
           -----------------
other party of any provision of this agreement relating to Confidential
Information would cause irreparable harm, that legal damages are not sufficient
to remedy any such breach, and that the sufficiency of legal damages shall not
constitute a ground for opposing any action for equitable relief with respect to
any breach or prospective breach of any such provision.  LICENSEE shall be
entitled to seek equitable relief with respect to the prospective termination of
this Agreement by UNIVERSITY.

                          ARTICLE XIII.  MISCELLANEOUS
                          ----------------------------

     13.1  Patent Policy.  This Agreement shall be subject to the Boston
           -------------
University Patent Policy, Charles River Campus, as in effect as of the Effective
Date, a copy of which is attached hereto as Exhibit B.

     13.2  Notices.  Any consent, notice or report required or permitted to
           -------
be given or made under this Agreement by one party to the other party shall be
in writing, shall be delivered personally, by confirmed facsimile transmissions,
or by U.S. first class mail, courier or nationally recognized delivery service,
and shall be addressed to the other party at its address indicated below, or to
such other address as the addressee shall have last furnished in writing to the
addressor.  Except as otherwise provided in the Agreement, such consent, notice
or report shall be effective upon receipt by the addressee.

     If to UNIVERSITY:

          Boston University
          Office of Technology Transfer
          Community Technology Fund
          80 East Concord Street, Suite L307C
          Boston, Massachusetts 02118
          Attention: Director
          Tel:  (617) 638-4540
          Fax:  (617) 638-4515

                                                                 -Page 14 of 23-
<PAGE>

     with a copy to:

           Boston University
           Office of General Counsel
           125 Bay State Road
           Boston, Massachusetts 02215
           Attention:  Dennis Hart, Esq.
           Tel: (617) 353-2326
           Fax: (617) 353-5529

     If to LICENSEE:

           Sequenom, Inc.
           c/o Techno Venture Management
           101 Arch Street,
           Suite 1950
           Boston, Massachusetts 02110
           Attention:    Dr. Hubert Koster
           Tel:  (617) 345-9320
           Fax:  (617) 345-9377

     with a copy to:

           Foley, Hoag & Eliot
           One Post Office Square
           Boston, Massachusetts 02109
           Attention:    David R. Pierson, Esq.
           Tel:  (617) 832-1000
           Fax:  (617) 832-7000

     13.3  Governing Law. This Agreement shall be governed by, and construed and
           -------------
enforced in accordance with, the laws of The Commonwealth of Massachusetts,
without regard to the conflicts of law principles thereof, and shall not be
governed by the United Nations Convention on Contracts for the International
Sale of Goods.

     13.4  U.S. Export Laws and Regulations.  Each party hereby
           --------------------------------
acknowledges that the rights and obligations of this Agreement are subject to
the laws and regulations of the United States relating to the export of products
and technical information.  Without limitation, each party shall comply with all
such laws and regulations.

     13.5  No Other Rights.  This Agreement shall not be construed to grant
           ---------------
any license or other rights to either party in any patent rights, know-how or
other technology of the other, except as expressly provided in this Agreement.

                                                                 -Page 15 of 23-
<PAGE>

     13.6  Waivers and Amendments.  No change, modification, extension,
           ----------------------
termination or waiver of this Agreement, or any of the provisions herein
contained, shall be valid unless made in writing and signed by duly authorized
representatives of the parties hereto.

     13.7  Entire Agreement.  This Agreement and the Sponsored Research
           ----------------
Agreement embody the entire understanding between the parties and supersede any
prior understanding and agreements between and among them respecting the subject
matter hereof.  There are no representations, agreements, arrangements or
understandings, oral or written, between the parties hereto relating to the
subject matter of this Agreement which are not fully expressed herein.

     13.8  Independent Contractors.  UNIVERSITY and LICENSEE are
           -----------------------
independent contractors and are not, and shall not represent themselves as,
principal and agent, partners or joint venturers.  Neither party shall attempt
to act, or represent itself as having the power, to bind the other or create any
obligation on behalf of the other.  Each party shall be solely responsible for
the employment, direction and control of its employees and their acts.

     13.9  Severability.  Whenever possible, each provision of this
           ------------
Agreement will be interpreted in such manner as to be effective and valid under
applicable law.  The parties agree that (i) the provisions of this Agreement
shall be severable in the event that any of the provisions hereof are for any
reason whatsoever invalid, void or otherwise unenforceable, (ii) such invalid,
void or otherwise unenforceable provisions shall be replaced by other provisions
which are as similar as possible in terms to such invalid, void or otherwise
unenforceable provisions but are valid and enforceable, and (iii) the remaining
provisions shall remain enforceable to the fullest extent permitted by law.

     13.10 Captions.  The Captions herein have been inserted solely for
           --------
convenience of reference and in no way define or limit the scope or substance of
any provision of this Agreement.

     13.11 Certain Additional Definitions.  As used in this Agreement,
           ------------------------------
"herein" and "hereof' shall refer to this Agreement as a whole, and "including"
shall mean "including but not limited to."

                                                                 -Page 16 of 23-
<PAGE>

     IN WITNESS WHEREOF, the parties have caused this Agreement to be
executed and  delivered as a document under seal by their duly authorized
officers, as of the date first above written.

SEQUENOM, INC. (LICENSEE)                   TRUSTEES OF BOSTON UNIVERSITY
                                            (UNIVERSITY)

By:  /s/ John J. DiBello                    By:____________________________
   -------------------------

Name:   John J. DiBello                     Name:  John Bagalay
     -----------------------

Title:  Treasurer/CFO                       Title:  Assistant Treasurer
      ----------------------

                                                                 -Page 17 of 23-
<PAGE>

     IN WITNESS WHEREOF, the parties have caused this Agreement to be executed
and delivered as a document under seal by their duly authorized officers, as of
the date first above written.



SEQUENOM, INC. (LICENSEE)                   TRUSTEES OF BOSTON UNIVERSITY
                                            (UNIVERSITY)

By:________________________                 By:  /s/ John Bagalay
                                               ---------------------------------

Name:______________________                 Name:  John Bagalay


Title:_____________________                 Title:  Assistant Treasurer

                                                                 -Page 18 of 23-
<PAGE>

                                                                       Exhibit A

                            UNIVERSITY Patent Rights

***


***


***


***


***


***


                                                                 -Page 19 of 23-


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treatment request and filed separately with the Commission.

<PAGE>

***


***


***


***
                                                                 -Page 20 of 23-



     *** Portions of this page have been omitted pursuant to confidential
treatment request and filed separately with the Commission.

<PAGE>

                                                                       Exhibit B

                                 Patent Policy

                                                                 -Page 21 of 23-
<PAGE>

Boston University Patent Policy                      [university logo]

CHARLES RIVER CAMPUS
- --------------------------------------------------------------------------------

PREAMBLE

The patent policy outlined herein is the Policy of the Trustees of Boston
University (the "University").  The University recognizes that patentable
inventions may be made in the course of research sponsored by the University
and/or by others through the University.  It is the policy of the University to
- ---
maximize the benefits to the individual who makes such patentable inventions, to
the University and to the general public, and thus to stimulate initiative in
the faculty, staff, and employees of the University.  The University recognizes
that this may best be accomplished through patenting and licensing such
inventions in a manner consistent with the public interest, and for such purpose
the University hereby establishes the patent policy set forth herein.  This
Policy supersedes all prior patent policies and amendments thereto applicable to
the Charles River Campus.

1.  PATENT POLICY

       A. In order to protect the public good and the University, and in order
to fulfill obligations to research sponsors, the University shall claim equity
in all discoveries and its right to acquire the title to and control of such
discoveries where the discoveries are made by faculty, staff, employees, or
students (including all types of trainees or postgraduate fellows) working on or
arising from programs supported in whole or in part by funds, space, personnel,
or facilities provided by the University.

      B.  When a discovery is made by an inventor outside of any program
conducted by the University, and the inventor can demonstrate that the
University did not provide or administer significant funds, space, personnel, or
facilities for work leading to the discovery, the discovery shall remain the
exclusive property of the inventor or his/her sponsor. The University shall not
ordinarily consider provision of office, classroom, or library facilities as
constituting significant use of University funds, space, personnel, or
facilities. For purposes of this Policy, the term "Inventor" shall include all
individuals who participated in and signed a disclosure statement respecting a
discovery or invention.

     C.   When necessary, the University Committee on Inventions and Discoveries
("Committee") shall decide whether an invention or discovery should be
classified under Paragraph A or Paragraph B of this Paragraph 1. Persons or
entities claiming a right to receive royalty interests under the provisions of
Paragraph 4 may appeal the decision of the Committee to the President of the
University. The President shall recommend final action to the Trustees, whose
decision shall be final.

2.  ROYALTIES

Where the University is entitled to equity in a discovery, the Inventor shall
receive 30 percent of the net royalties accruing therefrom unless the University
recommends a lesser share, which shall not be less than 15 percent, based upon
relevant circumstances relating to the discovery.  In the event that the
University determines that such lesser share is appropriate, the University
shall in its sole discretion designate the recipient or recipients of the
percentage share by which the Inventor's share has been reduced.  The Community
Technology Foundation (CTF) of Boston University, exclusive agent for the
administration of patents or discoveries made within the University, shall
receive 45 percent of the net royalties (see Paragraph 4).  The remaining
royalties from, and equities in, the invention shall be distributed to the
School of the Inventor, or in the absence of a School's being involved, the
primary unit or entity of the University with which the inventor works or is
affiliated.  Net royalties are defined as gross royalties less amounts granted
by the University specifically for the invention or discovery process, and the
costs of securing, protecting, preserving, and maintaining patents, and of
licensing and marketing of the patent rights, or other costs or fees directly
attributable to the inventions being licensed.

3.  DISCLOSURES

Because the securing of rights in discoveries and inventions depends on prompt
and efficient patent application and administration, all faculty, staff,
students, and employees of the University who make inventions or discoveries
shall immediately disclose said inventions or discoveries to the CTF Patent
Administrator and to the Inventor's supervisor.  This disclosure obligation
shall apply to all inventions and discoveries, without regard to whether they
fall under Paragraph A or B above.

4.  PATENT ADMINISTRATION

CTF shall be the exclusive agent of the University for the administration of
inventions and discoveries made within the University and covered under
Paragraph l.A.  CTF shall present the disclosures to the Committee.  Such report
shall state whether CTF has determined that an invention or discovery will be
developed by the University.  The Committee shall consist of eleven voting
members, at least a majority of whom shall be faculty members from the Schools
and Colleges of the University.  The members of the Committee and the Chairman
of the Committee shall be designated by the President of the University CTF.

<PAGE>

                                                                   EXHIBIT 10.26

                               LICENSE AGREEMENT

     THIS LICENSE AGREEMENT (the "Agreement") dated as of the 3rd day of July,
1997 (the "Effective Date"), is made by and between The Johns Hopkins
University, a corporation organized under the laws of Maryland (hereinafter
referred to as ("UNIVERSITY"), and Sequenom, Inc., a corporation organized under
the laws of Delaware (Sequenom, Inc. and any Affiliate of Sequenom, Inc.
hereinafter referred to as "LICENSEE").

                                  WITNESSETH

     WHEREAS, UNIVERSITY and LICENSEE have entered into a certain Research
Agreement, effective as of October 1, 1994 (the "Sponsored Research Agreement"),
pursuant to which UNIVERSITY granted to LICENSEE the right to negotiate for an
*** worldwide license to certain technology and a *** license to certain other
technology; and

     WHEREAS, UNIVERSITY and LICENSEE wish to set forth the terms of such
licenses;

     NOW, THEREFORE, in consideration of the foregoing premises and the mutual
covenants herein contained, the parties hereby agree as follows:

                                   ARTICLE 1

                                  DEFINITIONS
                                  -----------

     For purposes of the Agreement, the terms defined in this article shall have
the respective meanings set forth below:

     1.1  "Affiliate" shall mean, with respect to any Person, any other Person
           ---------
which directly or indirectly controls, is controlled by, or is under common
control with, such Person.  A Person shall be regarded as in control of another
Person if it directly or indirectly possesses the power to direct or cause the
direction of the management and policies of the other Person by any means
whatsoever.

     1.2  "Curved Filed Reflectron Patent Rights" shall mean the invention
           -------------------------------------
claimed in U.S. Patent No. 5,464,985, entitled "Non-Linear Field Reflectron."

     1.3  "Field" shall mean ***.
           -----

     1.4  "First Commercial Sale" shall mean, with respect to any Licensed
           ---------------------
Product, the first sale for use or consumption by the general public of such
Licensed Product.

     1.5  "Improvements" shall mean all inventions, discoveries, processes,
           ------------
methods, compositions, formulae, procedures, protocols, software developments
and improvements, techniques, results of experimentation and testing,
information and data, which are conceived by employees or others acting on
behalf of the Mass Spectrometry Lab of the School of Medicine of UNIVERSITY,
either alone or jointly with others, and which constitute improvements to the

*** - Portions of this page have been omitted pursuant to Confidential Treatment
request and filed separately, with the Commission.

                                       1
<PAGE>

UNIVERSITY Patent Rights, the Curved Field Reflectron Patent Rights, the
Inventions, or the Licensed Technology all to the extent and only to the extent
conceived, developed or reduced to practice by employees or others acting on
behalf of the Mass Spectrometry Lab of the School of Medicine of UNIVERSITY,
either alone or jointly with others, arising out of research conducted pursuant
to the Sponsored Research Agreement.

     1.6  "Inventions" shall mean all inventions arising out of research
           ----------
conducted pursuant to the Sponsored Research Agreement by the employees of the
Mass Spectrometry Lab of the School of Medicine of UNIVERSITY or by others whose
work is funded by the Sponsored Research Agreement.

     1.7  "Licensed Product" shall mean products or components arising out of or
           ----------------
using Inventions or methods related to mass spectrometer instruments or other
products or components which if made, used or sold would infringe one or more
Valid Patent Claims but for the license granted by the Agreement, or which
otherwise uses, incorporates or was conceived, developed or reduced to practice
using the Licensed Technology.

     1.8  "Licensed Service" shall mean a service that employs methods or
           ----------------
procedures covered by a Valid Patent Claim or that embodies or uses Licensed
Products.

     1.9  "Licensed Technology" shall mean all UNIVERSITY Patent Rights, and all
           -------------------
Inventions, together with all inventions, discoveries, processes, methods,
compositions, formulae, procedures, protocols, software developments and
improvements, techniques, results of experimentation and testing, information
and data, which are not generally known, embodying or produced through
inventions conceived, discovered or reduced to practice, whether alone or with
others, by employees of the Mass Spectrometry Lab of the School of Medicine of
UNIVERSITY or with facilities or equipment of such Mass Spectrometry Lab,
including any Improvements thereto; all to the extent and only to the extent
that UNIVERSITY has the right to grant licenses thereunder and all arising out
of research conducted pursuant to the Sponsored Research Agreement.

     1.10 "Net Selling Price" shall mean the gross amount billed or invoiced on
           -----------------
sales by LICENSEE of a mass spectrometer instrument or component thereof that is
a Licensed Product, or a Licensed Service, respectively, less the following: (i)
trade, quantity, or cash discounts and commissions to non-affiliated brokers or
agents to the extent actually allowed and taken; (ii) amounts repaid or credited
by reason of rejection or return; and (iii) any taxes, imposts, tariffs, custom
duties or other governmental charges levied on the production, sale,
transportation, delivery, or use of such product or service which are paid by or
on behalf of LICENSEE. The Net Selling Price for a Licensed Product that is a
mass spectrometer instrument or a component thereof shall be the Net Selling
Price of the entire mass spectrometer instrument, if the Licensed Product
contains at least a component that would infringe a Valid Patent Claim.

     1.11 "Person" shall mean an individual, corporation, partnership, trust,
            ------
business trust, association, joint stock company, limited liability company,
limited liability partnership, joint venture, pool, syndicate, sole
proprietorship, unincorporated organization, governmental authority or any other
form of entity not specifically listed herein.

                                       2
<PAGE>

     1.12  "Territory" shall mean all jurisdictions worldwide.
            ---------

     1.13  "Third Party" shall mean any Person other than UNIVERSITY, LICENSEE
            -----------
and their respective Affiliates.

     1.14  "UNIVERSITY Patent Rights" shall mean (a) all patent application,
            ------------------------
heretofore or hereafter filed or having legal force in any country within the
Territory, embodying or claiming Inventions conceived, discovered or reduced to
practice, whether alone or with others, by UNIVERSITY employees or with
UNIVERSITY facilities or equipment, in the course of any Research Program under
the Sponsored Research Agreement, (b) all patents that have issued or in the
future issue from the patent applications described in clause (a) above,
including utility, model and design patents and certificates of invention, and
(c) all divisions, continuations, continuations-in-part, reissues, renewals,
extensions or additions to any such patent applications and patents, and any
Improvements thereto upon which a patent application has been filed or a patent
has issued; provided, however, that UNIVERSITY Patent Rights shall not include
Curved Field Reflectron Patent Rights.

     1.15  "Valid Patent Claim" shall mean a claim of an issued and unexpired
            ------------------
patent included within the UNIVERSITY Patent Rights or Curved Field Reflectron
Patent Rights that has not been held permanently revoked, unenforceable or
invalid by a decision of a court or other governmental agency of competent
jurisdiction, which decision is unappealable or has not been appealed within the
time allowed for appeal, and that has not been admitted to be invalid or
unenforceable through reissue or disclaimer or otherwise.

                                   ARTICLE 2

                        REPRESENTATIONS AND WARRANTIES
                        ------------------------------

     Each party hereby represents and warrants to the other party as follows:

     2.1  Existence and Power.  Such Party is duly organized, validly existing
          -------------------
and in good standing under the laws of jurisdiction in which it is incorporated.

     2.2  Authorization and Enforcement of Obligations.  Such party (a) has the
          --------------------------------------------
power and authority and the legal right to enter into this Agreement and to
perform its obligations hereunder and (b) has taken all necessary action on its
part to authorize the execution and delivery of this Agreement and the
performance of its obligations hereunder.  This Agreement has been duly executed
and delivered on behalf of such party and constitutes a legal, valid and binding
obligation of such party, enforceable against such party in accordance with its
terms.

     2.3  No Consents.  All necessary consents, approvals and authorizations of
          -----------
all governmental authorities and other Persons required to be obtained by such
party in connection with this Agreement have been obtained.

                                       3
<PAGE>

     2.4  No Conflict.  The execution and delivery of this Agreement and the
          -----------
performance of such party's obligations hereunder (a) do not conflict with or
violate any requirement of applicable laws or regulations, and (b) do not
conflict with, or constitute a default under, any contractual obligation of it.

     2.5  Third Party Claims.  UNIVERSITY represents and warrants that, to the
          ------------------
best of its knowledge as of the signing of this Agreement, no claim has been
made by or is available to any Third Party that any activity permitted by the
licenses granted to LICENSEE pursuant to this Agreement constitutes an
infringement of any right of any such Third Party anywhere in the world,
including, without limitation, any right under any copyright, trademark, trade
secret, patent, or other proprietary right of such Third Party.

     2.6  Warranty: Warranty Disclaimer.  UNIVERSITY warrants that it has good
          -----------------------------
and marketable title to its interest in the inventions claimed under UNIVERSITY
Patent Rights and Curved Field Reflectron Patent Rights with the exception of
certain retained rights of the United States government.  UNIVERSITY does not
warrant the validity of any patents or that practice under such patents shall be
free of infringement.  EXCEPT AS EXPRESSLY SET FORTH IN THIS PARAGRAPH 2,
LICENSEE, AFFILIATED COMPANIES AND SUBLICENSEES AGREE THAT THE PATENT RIGHTS ARE
PROVIDED "AS IS", AND THAT UNIVERSITY MAKES NO REPRESENTATION OR WARRANTY WITH
RESPECT TO THE PERFORMANCE OF LICENSED PRODUCT(S) AND LICENSED SERVICES
INCLUDING THEIR SAFETY, EFFECTIVENESS, OR COMMERCIAL VIABILITY.  UNIVERSITY
DISCLAIMS ALL WARRANTIES WITH REGARD TO PRODUCT(S) AND SERVICES LICENSED UNDER
THIS AGREEMENT, INCLUDING, BUT NOT LIMITED TO, ALL WARRANTIES, EXPRESS OR
IMPLIED, OF MERCHANTABILITY AND FITNESS FOR ANY PARTICULAR PURPOSE.
NOTWITHSTANDING ANY OTHER PROVISION OF THIS AGREEMENT, UNIVERSITY ADDITIONALLY
DISCLAIMS ALL OBLIGATIONS AND LIABILITIES ON THE PART OF UNIVERSITY AND
INVENTORS, FOR DAMAGES, INCLUDING, BUT NOT LIMITED TO, DIRECT, INDIRECT,
SPECIAL, AND CONSEQUENTIAL DAMAGES, ATTORNEYS' AND EXPERTS' AND COURT COSTS
(EVEN IF UNIVERSITY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES, FEES OR
COSTS), ARISING OUT OF OR IN CONNECTION WITH THE MANUFACTURE, USE, OR SALE OF
THE PRODUCT(S) AND SERVICES LICENSED UNDER THIS AGREEMENT.  LICENSEE, ITS
AFFILIATES, AND ITS SUBLICENSEES ASSUME ALL RESPONSIBILITY AND LIABILITY FOR
LOSS OR DAMAGE CAUSED BY A PRODUCT AND SERVICE MANUFACTURED, USED OR SOLD BY
LICENSEE, ITS SUBLICENSEES AND AFFILIATES WHICH IS A LICENSED PRODUCT OR
LICENSED SERVICE AS DEFINED IN THIS AGREEMENT.

                                   ARTICLE 3

                                 LICENSE GRANT
                                 -------------

     3.1  License Grant to LICENSEE.  UNIVERSITY hereby grants LICENSEE the
          -------------------------
following licenses:

                                       4
<PAGE>

          (a)  a royalty-bearing, *** world-wide license, including the right to
grant sublicenses, in all fields, under all of UNIVERSITY's right, title and
interest, whether presently held or hereafter acquired, in and to the University
Patent Rights to develop, make, have made, use, sell, license, market and
otherwise exploit Licensed Products and Licensed Services or other products or
services in any field; and

          (b)  a *** royalty free license to develop, make, have made, use,
sell, license, market and otherwise exploit Licensed Product and Licensed
Services based on nonpatented Licensed Technology (i.e., not covered by a Valid
Patent Claim).

          (c)  a royalty-bearing, *** world-wide license, including the right to
grant sublicenses, under all of UNIVERSITY's right, title and interest, whether
presently held or hereafter acquired, in and to the Curved Field Reflectron
Patent Rights to develop, make, have made, use, sell, license, market and
otherwise exploit Licensed Products and Licensed Services within the Field.
LICENSEE acknowledges the existence of the licenses granted to Shimadzu-Kratos
and JEOL. UNIVERSITY will not grant any licenses under U.S. Patent No,
5,464,985, other than the existing licenses to ***. LICENSEE acknowledges that
without the consent of LICENSEE the licenses to *** may be assigned in
connection with an acquisition by either of them or may be terminated and a
substitute license be put in place that does not conflict with the existing or
target business of LICENSEE within the Field.

     3.2  Reservation of Certain Rights.  Notwithstanding the foregoing, the
          -----------------------------
license granted to LICENSEE by the Agreement is subject to the reservation of:
(a) the rights of the United States of America as set forth in Public Laws 96-
517 and 98-620  (codified at 35 U.S.C. 200 et seq.) if U.S. Government funding
                                           ------
is used and (b) the retained rights of UNIVERSITY to use the UNIVERSITY Patent
Rights or Curved Field Reflectron Patent Rights for its internal research
purposes. UNIVERSITY shall have the right to render *** the license set forth in
Section 3.1(a) above with respect to particular "subject inventions," as defined
in the Bayh-Dole Act, if and only if: (i) LICENSEE is not demonstrably engaged
in a significant research, development, manufacturing, marketing or licensing
program with respect to such subject inventions; or (ii) at any time after ***
after the Effective Date, within ninety (90) days after written notice from
UNIVERSITY, LICENSEE has not put the subject inventions into commercial use and
is not keeping such subject inventions reasonably available to the public; and
(iii) such failure does not result from actions or inactions of any agency whose
approval is required for commercial sales. This right shall be UNIVERSITY's sole
remedy for failure by LICENSEE to put products to commercial use or make them
available to the public.

     3.3  Technical Assistance.
          --------------------

          (a)  Upon execution of the Agreement, UNIVERSITY shall disclose and
make available to LICENSEE all information available to UNIVERSITY and not
previously disclosed to LICENSEE regarding the Licensed Technology.

          (b)  During the term of the Agreement, upon reasonable notice and
during normal business hours, UNIVERSITY, acting through Dr. Robert J. Cotter,
(a) shall provide

*** Portions of this page have been omitted pursuant to Confidential Treatment
request and filed separately with the Commission.

                                       5


<PAGE>

such technical assistance regarding the Licensed Technology as LICENSEE
reasonably requests to conduct its activities contemplated by the Agreement, (b)
shall make available to LICENSEE such technical personnel of UNIVERSITY as
reasonably necessary to provide the foregoing technical assistance, and (c)
shall disclose and make available to LICENSEE all information available to
UNIVERSITY and not previously disclosed to LICENSEE regarding the use of the
Licensed Technology. LICENSEE shall reimburse UNIVERSITY for research or
consulting costs agreed by the parties for any such technical assistance,
together with such reasonable out-of-pocket travel and other expenses incurred
by UNIVERSITY in providing such technical assistance as are approved in advance
by LICENSEE. UNIVERSITY shall provide LICENSEE with estimates of the anticipated
costs of any requested technical assistance prior to undertaking such technical
assistance. If such technical assistance requires a significant level of
research the UNIVERSITY and LICENSEE will negotiate a separate sponsored
research agreement to cover such research.

                                   ARTICLE 4

                                   PAYMENTS
                                   --------

     4.1  Processing Fee.  LICENSEE will pay UNIVERSITY a processing fee of
          --------------
*** promptly after execution of this Agreement.

     4.2  Maintenance Fee.  LICENSEE will pay UNIVERSITY a maintenance fee of
          ---------------
*** within thirty days after each anniversary of execution of this Agreement,
in order to maintain the licenses granted pursuant to Article 3.

     4.3  Royalty.  LICENSEE shall pay UNIVERSITY one or the other of the
          -------
following royalties, if applicable:

          (a)  *** of the Net Selling Price received by LICENSEE of its
Affiliate for each Licensed Product having one or more features covered by a
Valid Patent Claim for which LICENSEE has an exclusive license, or *** of the
Net Selling Price received by LICENSEE for each such Licensed Product having one
or more features covered by a Valid Patent Claim for which LICENSEE has a non-
exclusive license;

          (b)  *** of the entire income stream received by LICENSEE or its
affiliates attributable to service income based in whole or in part on use of
either: (i) a Licensed Product in any jurisdiction where at least a component is
covered by a Valid Patent Claim, or (ii) methods or procedures covered by a
Valid Patent Claim, or (iii) components (other than a Licensed Product) covered
by a Valid Patent Claim, or used according to a method covered by a Valid Patent
Claim, where such Licensed Product, method, procedure or component or invention
is one for which LICENSEE has an exclusive license, or *** of the entire income
stream received by LICENSEE attributable to service income based in whole or in
part on use of either: (x) a Licensed Product in any jurisdiction where at least
a component is covered by a Valid Patent Claim, or (y) methods or procedures
covered by a Valid Patent Claim, or (z) components (other than a Licensed
Product) covered by a Valid Patent Claim, or used according to a method

*** - Portions of this page have been omitted pursuant to Confidential Treatment
request and filed separately, with the Commission.

                                       6
<PAGE>

covered by a Valid Patent Claim, where such Licensed Product, method, procedure
or component or invention is one for which LICENSEE has a non-exclusive license;

          (c)  *** of the entire sublicensing income received by LICENSEE
attributable in whole or in part to use of Licensed Products or other components
or methods covered by a Valid Patent Claim for which LICENSEE has an exclusive
LICENSE, or *** of the entire sublicensing income received by LICENSEE
attributable in whole or in part to use of Licensed Products or other components
or methods covered by a Valid Patent Claim for which LICENSEE has a non-
exclusive license;

          (d)  *** of the Net Selling Price received by LICENSEE for
consumables, including chips, not covered by items (b) and (c) above, but sold
for use on mass spectrometer instruments for which LICENSEE has an exclusive
license or for use according to methods or procedures covered by a Valid Patent
Claim for which Licensee has an exclusive license, or *** of the Net Selling
Price received by LICENSEE for consumables, including chips, not covered by
items (b) and (c) above, but sold for use on mass spectrometer instruments for
which LICENSEE has a non-exclusive license or for use according to methods or
procedures covered by a Valid Patent Claim for which Licensee has a non-
exclusive license.

LICENSEE shall be required to pay royalties only with respect to jurisdictions
where its sale or income is attributable to activities that are covered by a
Valid Patent Claim for which LICENSEE has a license hereunder.

     4.4  Payments.  All royalties pursuant to Section 4.3 shall accrue on the
          --------
date on which LICENSEE actually receives payment with respect to sales or income
with respect to particular Licensed Product or Licensed Services.  All royalties
pursuant to Section 4.3 shall be paid on a quarterly basis, within 60 days
following the end of the quarter in which they accrued.  Each payment shall be
accompanied by a report setting forth the calculation of the amount due.

     4.5  Credits.
          -------

          (a)  If LICENSEE must pay royalties to Third Parties for a product of
service for which it is also paying royalties to UNIVERSITY under Section 4.3
above, LICENSEE may credit against any amounts due UNIVERSITY *** of such
payment to Third Parties for such particular product or service. In addition, if
license fees and royalties payable to UNIVERSITY and to Third Parties on a
LICENSEE product or component thereof exceed *** of the net sales price of such
product of component or *** of LICENSEE's net income with respect to services or
sublicenses in any jurisdiction, LICENSEE may reduce any amounts due UNIVERSITY
pro rata with the amounts due Third Parties so that the total license fees and
royalties are reduced to *** or such net sales price or such net income,
respectively. In no event shall any payment otherwise due UNIVERSITY be reduced
by more than ***.

          (b)  LICENSEE may credit against any amounts due UNIVERSITY under this
Agreement, from sale or income generated in the jurisdiction of the infringement
suit, its share of expenses relating to the prosecution, defense or settlement
of infringement claims relating to the

*** - Portions of this page have been omitted pursuant to Confidential Treatment
request and filed separately, with the Commission.

                                       7




<PAGE>

practice of the licenses granted hereunder or the Inventions or the Curved Field
Reflectron Invention; however such credit may not decrease the royalty due
UNIVERSITY by more than *** in any year, the difference being carried forward
as a credit for future years.

                                   ARTICLE 5

                     INFRINGEMENT ACTIONS BY THIRD PARTIES
                     -------------------------------------

     UNIVERSITY shall indemnify and hold harmless LICENSEE and LICENSEE's
permitted sublicensees and customers from and against any and all losses, costs,
damages and expenses, including reasonable attorney's fees, resulting from any
suit or action arising out of or relating to any infringement or alleged
infringement by LICENSEE or by LICENSEE's permitted sublicensees or customers of
a Third Party's patent rights in the Territory through the use, sale,
manufacture, or practice of a process, method or composition claimed under the
Licensed Technology. LICENSEE promptly shall notify UNIVERSITY in writing of any
such suit or action, and UNIVERSITY shall have the right, at its expense, to
intervene and assume control of such action; provided, however, that LICENSEE
shall have the rights to participate in any such suit or action, to be
represented by advisory counsel of its own selection at its own expense, and to
offset *** of the expenses incurred in such action against any
amounts due UNIVERSITY. Neither party shall settle such suit or action without
the consent of the other, which consent shall not be unreasonably withheld or
delayed. Each party shall cooperate fully in the defense of such suit or action
and shall furnish to the other all evidence and assistance in its control.

                                   ARTICLE 6

                         PUBLICITY AND CONFIDENTIALITY
                         -----------------------------

     6.1  Publicity. The parties shall agree on the form of a mutually
          ---------
acceptable public announcements of the transaction contemplated hereby. Each
party shall otherwise hold the financial terms of this transaction in
confidence, except that LICENSEE may reveal such terms to any other licensee for
purposes of calculating license fees or royalties due subject to an obligation
of confidentiality, or to any prospective investor.

     6.2  Confidential Information. Each party shall exercise reasonable care to
          ------------------------
maintain in confidence all information of the other party (including samples)
disclosed by the other party and identified as, or acknowledged to be,
confidential (the "Confidential Information"), and shall not use, disclose or
grant rights to use of the Confidential Information except on a need-to-know
basis to those directors, officers, employees, agents, permitted sublicensees
and permitted assignees, to the extent such disclosure is reasonably necessary
in connection with such party's activities as authorized under this Agreement.
Each party shall notify the other promptly upon discovery of any unauthorized
use or disclosure of the other party's Confidential Information.

     6.3  Permitted Disclosures. The nonuse and nondisclosure obligations
          ---------------------
contained in this article shall not apply to the extent that (a) any receiving
party (the "Recipient") is required (i) to disclose information by law, order or
regulation of a governmental agency or a court of

*** - Portions of this page have been omitted pursuant to Confidential Treatment
request and filed separately, with the Commission.

                                       8
<PAGE>

competent jurisdiction, or (ii) to disclose information to any governmental
agency for purposes of obtaining approval to test or market a product or to
apply for a patent, provided that the Recipient shall provide written notice
thereof to the other party and sufficient opportunity to object, time
permitting, to any such disclosure or to request confidential treatment thereof;
or (b) the Recipient can demonstrate that (i) the information was public
knowledge at the time of such disclosure by the Recipient, or thereafter became
public knowledge, other than as a result of acts attributable to the Recipient
in violation hereof; (ii) the information was rightfully known by the Recipient
(as shown by its written records) prior to the date of disclosure to the
Recipient on an unrestricted basis by a Third Party not under a duty of
confidentiality to the other party; or (iv) the information was independently
developed by employees or agents of the Recipient without access to the
Confidential Information of the other party.

                                   ARTICLE 7

                            INVENTIONS AND PATENTS
                            ----------------------

     7.1  Ownership of Inventions. Ownership of Licensed Technology developed
          -----------------------
by individuals providing technical assistance on behalf of UNIVERSITY pursuant
to Section 3.3 of this Agreement shall be governed as if such Licensed
Technology were developed pursuant to the Sponsored Research Agreement.

     7.2  Patent Rights Generally. Control over, and associated expenses for,
          -----------------------
the filing, prosecution, and maintenance of patents and patent applications
relating to inventions licensed hereunder will be allocated according to the
Sponsored Research Agreement. In the event that UNIVERSITY obtains additional
licensees under any invention licensed by LICENSEE, LICENSEE shall pay only its
pro-rata share of patent-related expenses. LICENSEE shall have the right to
cease paying for the filing, prosecution, or maintenance of any patent or patent
application in any country upon thirty (30) days prior written notice to
UNIVERSITY. In such event, LICENSEE will have no further rights under this
Agreement with respect to such patent or patent application in such country, and
LICENSEE agrees to assign to UNIVERSITY any rights LICENSEE may have in such
patent or patent application in such country.

     7.3  Reimbursement of Expenses. LICENSEE shall reimburse UNIVERSITY for
          -------------------------
the reasonable expenses incurred by UNIVERSITY in relation to the filing,
prosecution, and maintenance of patents and patent applications licensed
hereunder; provided, however, that such expenses shall be equally divided among
LICENSEE and any other licensees of the Licensed Technology. Without limiting
the generality of the foregoing, LICENSEE will reimburse UNIVERSITY only one-
third of such expenses with respect to the Curved Field Reflectron Invention.

     7.4  Enforcement of UNIVERSITY Patent Rights.  UNIVERSITY shall notify
          ---------------------------------------
LICENSEE of any infringement in the Territory known to UNIVERSITY of the
Licensed Technology and shall provide LICENSEE with the available evidence, if
any, of such infringement. LICENSEE, at its expense, shall have the right to
determine the appropriate course of action to enforce rights in the Licensed
Technology or otherwise abate the infringement thereof, to take (or refrain from
taking) appropriate action to enforce the rights in

                                       9
<PAGE>

the Licensed Technology, to control any litigation or other enforcement action
and to enter into, or permit, the settlement of any such litigation or other
enforcement action with respect to the Licensing Technology. UNIVERSITY shall
cooperate fully with LICENSEE in connection with such litigation or other
enforcement action and shall furnish to LICENSEE all evidence and assistance in
its control. The proceeds of any monetary judgement, reward or settlement from
such litigation or other enforcement action shall be used first to reimburse
LICENSEE for its expenses. UNIVERSITY will receive a percentage of such proceeds
remaining after deduction of such expenses equal to the running royalty rate set
forth in Section 4.3(a), (b), (c) or (d) most nearly applicable to the activity
in question, and LICENSEE will retain any remaining amounts.

                                   ARTICLE 8

                             TERM AND TERMINATION
                             --------------------

     8.1  Term. This Agreement shall expire upon the expiration of the last to
          ----
expire patent included within the UNIVERSITY Patent Rights or Curved Field
Reflectron Patent Rights.

     8.2  Termination by LICENSEE. LICENSEE may terminate the Agreement, in its
          -----------------------
sole discretion, upon written notice to UNIVERSITY.

     8.3  Termination for Cause. Except as otherwise provided in the article
          ---------------------
below regarding force majeure, either party may terminate the Agreement upon or
after the breach of any material provision of the Agreement by the other party,
if the other party has not cured such breach within sixty (60) days after
written notice thereof by the non-breaching party.

     8.4  Effect of Expiration or Termination. Expiration of termination of the
          -----------------------------------
Agreement shall not relieve the parties of any obligation accruing prior to such
expiration or termination, and the provisions of Articles 5, 6, and 10 shall
survive the expiration or termination of the Agreement. Upon expiration of the
Agreement under Section 8.1 above, LICENSEE shall have a fully-paid, non-
exclusive license to make, have made, use, sell, license, market and otherwise
exploit Licensed Products and Licensed Technology anywhere in the world.

                                   ARTICLE 9

                                 FORCE MAJEURE
                                 -------------

     Neither party shall be held liable or responsible to the other party nor be
deemed to have defaulted under or breached the Agreement for failure or delay in
fulfilling or performing any term of this Agreement to the extent, and for so
long as, such failure or delay is caused by or results from causes beyond the
reasonable control of the affected party including but not limited to fires,
earthquakes, floods, embargoes, wars, acts of war (whether war is declared or
not), insurrections, riots, civil commotions, strikes, lockouts or other labor
disturbances, acts of God or acts, omissions or delays in acting by any
governmental authority or other party.

                                  ARTICLE 10

                                       10
<PAGE>

                                 MISCELLANEOUS
                                 -------------

     10.1  Limited Liability. In no event shall either party be liable to the
           -----------------
other or any Third Party for any special, consequential or incidental damages
arising out of or related to this Agreement or with respect to any claim,
demand, action or other proceeding relating to this Agreement however caused, or
any theory of liability (including negligence), whether or not the party has
been advised of the possibility of such damages.

     10.2  Notices.  Any consent, notice or report required or permitted to be
           -------
given or made under this Agreement by one party to the other party shall be in
writing, shall be delivered personally, by confirmed facsimile transmissions, or
by U.S. first class mail, courier or nationally-recognized delivery service, and
shall be addressed to the other party at its address indicated below, or to such
other address as the addressee shall have last furnished in writing to the
addressor. Except as otherwise provided in the Agreement, such consent, notice
or report shall be effective upon receipt by the addressee.

     If to UNIVERSITY:

     The Johns Hopkins University School of Medicine
     Office of Technology Licensing
     2024 E. Monument Street, Suite 2-100
     Baltimore, Maryland  21205
     Attention:  Howard W. Califano, Esq.
     Tel:   (410) 955-4666
     Fax:   (410) 955-1245

     If to LICENSEE:

     Sequenom, Inc.
     11555 Sorrento Valley Road, Suite C
     San Diego, California  92121
     Attention:  Dr. Hubert Koster
     Tel:   (619) 350-0345
     Fax:   (619) 350-0344

     with a copy to:

     David R. Pierson, Esq.
     Foley, Hoag & Eliot LLP
     One Post Office Square
     Boston, Massachusetts  02109
     Tel:   (617) 832-1000
     Fax:   (617) 832-7000

     10.3  Governing Law.  This Agreement shall be governed by, and construed
           -------------
and enforced in accordance with, the laws of the State of California, without
regard to the conflicts of

                                       11
<PAGE>

law principles thereof, and shall not be governed by the United Nations
Convention on Contracts for the International Sale of Goods.

     10.4  U.S. Export Laws and Regulations.  Each party hereby acknowledges
           --------------------------------
that the rights and obligations of this Agreement are subject to the laws and
regulations of the United States relating to the export of products and
technical information.  Without limitation, each party shall comply with all
such laws and regulations.

     10.5  No Other Rights.  This Agreement shall not be construed to grant any
           ---------------
license or other rights to either party in any patent rights, know-how or other
technology of the other, except as expressly provided in this Agreement.

     10.6  Waivers and Amendments.  No change, modification, extension,
           ----------------------
termination or waiver of this Agreement, or any of the provisions herein
contained, shall be valid unless made in writing and signed by duly authorized
representatives of the parties hereto.

     10.7  Entire Agreement.  This Agreement and the Sponsored Research
           ----------------
Agreement embody the entire understanding between the parties and supersede any
prior understanding and agreements between them respecting the subject matter
hereof. There are no representations, agreements, arrangements or
understandings, oral or written, between the parties hereto relating to the
subject matter of this Agreement and the Sponsored Research which are not fully
expressed herein and therein.

     10.8  Independent Contractors.  UNIVERSITY and LICENSEE are independent
           -----------------------
contractors and are not, and shall not represent themselves as, principal and
agent, partners or joint venturers. Neither party shall attempt to act, or
represent itself as having the power, to bind the other or create any obligation
on behalf of the other. Each party shall be solely responsible for the
employment, direction and control of its employees and their acts.

     10.9  Severability.  Whenever possible, each provision of this Agreement
           ------------
will be interpreted in such a manner as to be effective and valid under
applicable law. The parties agree that (i) the provisions of this Agreement
shall be severable in the event that any of the provisions here are for any
reason whatever invalid, void or otherwise unenforceable, (ii) such invalid,
void or otherwise unenforceable provisions shall be replaced by other provisions
which are as similar as possible in terms to such invalid, void or otherwise
unenforceable provisions but are valid and enforceable, and (iii) the remaining
provisions shall remain enforceable to the fullest extent permitted by law.

     10.10  Captions.  The captions herein have been inserted solely for
            --------
convenience of reference and in no way define or limit the scope or substance of
any provision of this Agreement.

     10.11  Use of Names.  Neither party will use the name of the other party or
            ------------
of any investigator in any advertising or other form of publicity without the
prior written permission of the other, except that LICENSEE shall have the right
to identify UNIVERSITY and to disclose the terms of this Agreement in any
prospectus, offering memorandum, or other document or

                                       12
<PAGE>

filing required by applicable securities laws or other applicable law or
regulation, provided that LICENSEE shall have given to UNIVERSITY at least five
(5) days prior written notice of the proposed text of any such identification of
disclosure for the purpose of giving UNIVERSITY the opportunity to comment on
such proposed text.

     10.12  No Control; Indemnification.  UNIVERSITY and the inventors of
            ---------------------------
Licensed Products and Licensed Services will not under the provisions of this
Agreement or otherwise, have control over the manner in which LICENSEE or its
Affiliates or its sublicensees or those operating for its account or third
parties who purchased Licensed Products or Licensed Services from any of the
foregoing entities, practice the inventions of Licensed Products or Licensed
Services. The LICENSEE shall defend and hold the UNIVERSITY, The Johns Hopkins
Health Systems, their present and former regents, trustees, officers, inventors
of PATENT RIGHTS, agents, faculty, employees and students harmless as against
any judgements, fees, expenses, or other costs arising from or incidental to any
product liability or other lawsuit, claim, demand or other action brought as a
consequence of the practice of said inventions by any of the foregoing entities,
whether or not JHU or said inventors, either jointly or severally, is named as a
party defendant in any such lawsuit, provided that any party claiming
indemnification under this Section 10.12 provided Sequenom with assistance and
sole control in the defense or settlement of any lawsuit, claim, demand or other
action. Practice of the inventions covered by Licensed Products and Licensed
Services by an Affiliate or an agent or a sublicensee or a third party on behalf
of or for the account of the LICENSEE or by a third party who purchases Licensed
Products and Licensed Services from the LICENSEE, shall be considered LICENSEE's
practice of said inventions for purposes of this Section 10.12. The obligation
of the Company to defend and indemnify as set out in this Section 10.12 shall
survive the termination of this Agreement.

     10.13  Insurance. Prior to initial human testing or first commercial sale
            ---------
of any Licensed Product or Licensed Service as the case may be in any particular
country, the LICENSEE shall establish and maintain, in each country in which
LICENSEE, an Affiliate or sublicensee shall test or sell Licensed Products or
Licensed Services, product liability or other appropriate insurance coverage
appropriate to the risks involved in marketing Licensed Products and Licensed
Services and will annually present evidence to the UNIVERSITY that such coverage
is being maintained. Upon UNIVERSITY's request, the LICENSEE will furnish
UNIVERSITY with a Certificate of Insurance of each product liability insurance
policy obtained and agrees to increase or change the kind of insurance
pertaining to the Licensed Products and Licensed Services at the reasonable
request of the UNIVERSITY. The UNIVERSITY shall be listed as an additional
insured in LICENSEE's said insurance policies.

     10.14  Certain Additional Definitions.  As used in this Agreement, "herein"
            ------------------------------
and "hereof" shall refer to this Agreement as a whole, and "including" shall
mean "including but not limited to."

     10.15  Additional Licenses.  It is the intention of UNIVERSITY and LICENSEE
            -------------------
that if UNIVERSITY and LICENSEE hereafter enter into additional sponsored
research agreements, any licenses granted to LICENSEE with respect to inventions
made pursuant thereto shall be on terms comparable to those set forth herein,
unless UNIVERSITY and LICENSEE otherwise agree in writing in such additional
sponsored research agreement.

                                       13
<PAGE>

     IN WITNESS WHEREOF, the parties have caused this Agreement to be executed
and delivered as a document under seal by their duly authorized officers, as of
the date first above written.

SEQUENOM, INC.                          THE JOHNS HOPKINS UNIVERSITY


      /s/  Hubert Koster                     /s/   illegible
- ------------------------------          ----------------------------
By:   Dr. Hubert Koster                 By:
Its:  Executive Vice President          Its:
      Chief Technical Officer

                                       14

<PAGE>

                                                                   EXHIBIT 10.27

                                   SEQUENOM


                                   AGREEMENT


by and between

PD Dr. Bertram Mhller-Myhsok
Markusstr. 11
20355 Hamburg
Germany
                           hereinafter called `BMM'

and

SEQUENOM Instruments GmbH
Mendelssohnstr. 15 D
22761 Hamburg
Germany
                           hereinafter called `SEQ'


Preamble
SEQ is establishing a proprietary [***].
BMM will provide SEQ with [***] (the "Product"), out of which SEQ will [***]
which covers the human genome with a [***] thus offering high resolution in gene
mapping projects.

Product Specification
BMM will provide SEQ with [***] human DNA marker sequences, with the
heterozygous rate [***] Primarily, such markers will include [***].
The markers will be spread equally over the human genome, enabling Sequenom to
select a final portfolio of [***] with an [***], and to use such markers within
gene mapping and linkage analysis projects.

PCR product size (to be indicated for each marker) should not exceed [***]
nucleotides.
PROBE(TM) products should - including primer - not exceed [***] nucleotides.

Delivery Time
The first list of 100 markers will be provided to SEQ within 30 days following
signature of this agreement. The full list of [***] markers will be provided to
SEQ within 90 days following signature of this agreement.

[***] Portions of this page have been omitted pursuant to Confidential Treatment
request and filed separately with the Commission.

<PAGE>

                                   SEQUENOM


Compensation
(I)  SEO will pay to BMM
(a)  immediately upon signature of this agreement DM [***]
(b)  upon delivery of the list of [***] markers DM [***]

(II) Upon delivery of the list of [***] markers to SEQ, Sequenom, Inc., 11555
Sorrento Valley Rd., San Diego, CA 92121, USA will grant to BMM options to
purchase [***] shares in Sequenom common stock at a share price of US$[***] per
share on or before December 31, 2002.
If Sequenom, Inc., does not float shares with a US or European stock market on
or before July 31, 1999, Sequenom, Inc., will buy back - on BMM's written
request - such options, at an option price equivalent to the share price agreed
upon with institutional investors for equity investments or private placements
in Sequenom common stock and executed within 1999.
Upon execution of the options by BMM, SEQ will reimburse BMM for the nominal
share value of US$ [***] per share.

Law, Jurisdiction
This agreement is governed by German law.
Place of jurisdiction is Hamburg.


Hamburg,                                           Hamburg, July 08, 1997

/s/ Dr. Bertram Mhller-Myhsok                      /s/ Dr. Toni Schuh

Dr. Bertram Mhller-Myhsok                          Sequenom Instruments GmbH
                                                   Dr. Toni Schuh
                                                   Managing Director



                                                   /s/ Prof. Dr. Hubert K'ster

                                                   Sequenom, Inc.
                                                   Prof. Dr. Hubert K'ster
                                                   Executive Vice President
                                                   Chief Technology Officer


[***] Portions of this page have been omitted pursuant to Confidential Treatment
request and filed separately with the Commission.


<PAGE>

                                                                   Exhibit 10.28

                                   Agreement

                                    between


     Community Technology Fund, Office of Technology Transfer of Community
Technology Fund and Center for Advanced Biotechnology (BU) represented by Matt
Burns, Heather Tullar, Ashley Stevens and Charles Cantor.

                                      and

     Sequenom, San Diego, CA and Sequenom GmbH, Germany represented by Hubert
Koster.

1)   The patents         ***        will be moved from the     ***    category
to the   ***     category, as marked in Exhibit A.


2)   As a precondition of Sequenom submitting payment of all retroactive and
future patent costs according to Section 3, BU will supply to Sequenom copies of
all relevant documents regarding the patent fillings and prosecution of said
cases.

3)   Sequenom agrees that in the case that a license agreement is entered into
between BU and     ***    it will pay retroactive and prospective patent costs
in the amount of    ***  of the *** category (estimated through *** *** of the
*** category (estimated through *** immediately upon receipt of documents
described in Section 2.

     Should the License Agreement between BU and   ***  not be fully executed
within ten (10) days of this Letter of Agreement, Sequenom agrees to pay the
full cost for retroactive and future patent costs for both the     ***
category and the   ***         category as previously described.  This payment
is due immediately upon both delivery of the documents described in Section 2
and notification of the canceling of the proposed License Agreement between BU
and ***.

     BU will make a good faith effort to recover a pro rata share of previously
incurred costs for the       ***    category in future license agreements and,
if successful, will reimburse Sequenom the pro rata share.

4)   The Sponsored Research Agreement will be continued from 9/15/96 through
9/14/98 with payments as listed in the letter from Sequenom dated 9/16/97
attached hereto as Exhibit B.

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

5)   The License Agreement between BU and Sequenom dated 6/1/96 will cover
inventions and patents describing developments in the laboratory of Dr. Charles
Cantor for the duration of the Sponsored Research Agreement in the field of
                                      ***
     ***        This will be clarified by an addendum to the existing license
agreement .
6)   The scientific program of collaboration between Sequenom and BU will be
formulated and continuously updated by the Principal Investigator and Sequenom.


     Agreed in Boston on October 8, 1997


     /s/  illegible
     ------------------------------------
     Sequenom


     /s/  illegible
     ------------------------------------
     Community Technology Fund


     /s/  illegible
     ------------------------------------
     Office of Technology Transfer

     ____________________________________
     Center for Advanced Biotechnology

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

Invoice
- -------

Licensee            Sequenom
Bill Prepared              8/27/97
Law Firm                   Baker & Botts
Agreement Date 7/1/96

***



<TABLE>
<CAPTION>
          BU Case             Docket                       Services                      Amount
          -------             ------                       --------                      ------
<S>                           <C>                          <C>                           <C>
92-42                         0107                         Inception - 5/15/97           ***
92-42                         0124                         Inception - 5/15/97           ***
92-42                         0162                         Inception - 5/15/97           ***
92-42                         0168                         Inception - 5/15/97           ***
92-42B                        0186                         Inception - 5/15/97           ***
92-42                         0187                         Inception - 5/15/97           ***
92-42                         0215                         Inception - 5/15/97           ***
92-42                         0217                         Inception - 5/15/97           ***
92-42B                        0228                         Inception - 5/15/97           ***
92-42                         0325                         Inception - 5/15/97           ***
                              ---------------------------- -----------------------   ------------------
                              Total                                                      ***

***

92-42C                        0167                         Inception - 5/15/97           ***
92-42C                        0216                         Inception - 5/15/97           ***
92-42C                        0276                         Inception - 5/15/97           ***
92-42C                        0302                         Inception - 5/15/97           ***
- ---------------------------   ---------------------------- -----------------------   ------------------
                              Total                                                      ***

                              Grand Total                                                ***
                              -----------                                            ------------------

                              Payments Received            6/27/97                       ***
                              ----------------------------
                                                           7/27/97                       ***
                                                                                     ------------------
                              Balance Due                                                ***
</TABLE>

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

September 16, 1997


Charles Cantor
Center for Advanced Biotechnology
Boston University
36 Cummington Street
Boston, MA  02215


Dear Charles,

It was a pleasure having you at our facility in San Diego.

This letter comprises in principle our intention to move forward on a
renegotiated Research Agreement in return for a "field of use" on related
technology developed in your lab. It includes our budget proposal for the
retroactive period including September 1996 through September 1997 and outlines
the budget for September 1997 through September 1998.

The following budget proposals include consideration of the August 29, 1997 memo
from Matt Barber regarding the lab budgets for 9/96 -  9/97 and 9/97 - 9/98.

1996 - 1997 Budget
- ------------------

Our attached budget proposal for 1996 - 1997 of   ***  though less than your
budget of *** is a significant increase from our original proposal of
***  The salary of the lab manager and reduced supplies are the material items
reduced from your proposal.

1997 - 1998 Budget
- ------------------

Budget restraints require us to reduce your 1997 - 1998 budget proposal.  The
major items deleted include reducing Dr. Cantor's time reduced to 20% and
deleting the Lab Manager and grad student.  The supplies and other expenses were
also reduced by 45%.  The adjusted budget total of   ***  still represents a
major investment over the coming year.

We hope you view this proposal as a significant commitment to continue our
valuable relationship with Boston University.

Best Regards,

/s/ Steve Zaniboni

Steve Zaniboni
Vice President, Finance & Administration

CC:  H. Koster
     M. Barber

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                   Sequenom,
                         Boston University Lab Budget
                       September 1996 to September 1997


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     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                   Sequenom,
                         Boston University Lab Budget
                       September 1996 to September 1997


                                      ***
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     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

                                                                   EXHIBIT 10.29

                            Collaboration Agreement

                                by and between


Bruker-Franzen Anajytik GmbH
Fahrenheitstr. 4
28359 Bremen                            hereinafter referred to as `Bruker'

and

Sequenom Instruments GmbH
Mendelssohnstr. 15 D
22761 Hamburg                           hereinafter referred to as `Sequenom'

                                        November 24, 1997


                                   Preamble

(1)  Bruker-Franzen Analytik develops and manufactures mass spectrometers and
     supplies such instruments on a worldwide scale.

     Bruker-Franzen Analytik has exclusive intellectual property rights and
     know-how, covering
     .   MALDI-TOF mass spectrometer technology
     .   Pulsed Ion Extraction
     .   Multi-Target Acquisition
     .   Postprocessing XMASS(TM) software.

     Bruker-Franzen Analytik maintains an organisation appropriate for the
     manufacture, marketing and customer service with regard to such mass
     spectrometers.

(2)  Sequenom has exclusive intellectual property rights and know-how, covering
     Sequenom's DNA MassArray(TM) technology basis and comprising
     .   Sample preparation and sample conditioning of nucleic acids, optimized
         for MS separation and detection
     .   DNA analysis application formats specifically designed for MS analysis
         (BiomassSIZE(TM), BiomassSCAN(TM), BiomassPROBE(TM) BiomassSEQUENCE
         (TM), BiomassINDEX(TM))
     .   Parallel processing features, applying DNA chips (SpectroChip(TM)) and
         multiplexing
     .   Separation and detection of nucleic acids by MS, incl. analytical and
         diagnostic applications.

(3)  The parties intend to establish a broad relationship focusing on ***
     subject to the experience within this Collaboration.

*** - Portions of this page have been omitted pursuant to Confidential Treatment
request and filed separately, with the Commission.
<PAGE>

Collaboration

(1)  Bruker-Franzen and Sequenom intend to collaborate in the manufacture and
     marketing of and in the provision of customer service for *** designed to
     process Sequenom's SpectroChips(TM) (the "Mass Spectrometer") under a joint
     Bruker-Franzen -- Sequenom logo.

     The Mass Spectrometer will be made available as stand-alone instrument and
     will be integrated by Sequenom in collaboration with highly qualified
     instrument manufacturers in the area of microliter and nanoliter liquid
     handling, mass spectrometry and system integration in modular analytical
     lines (the "Modular System"), comprising automatic liquid handling modules,
     DNA amplification and sequencing modules, sample-to-chip transfer modules
     and controlling and data management units. The Modular System will be
     designed to run applications of Sequenom's DNA MassArray(TM) technology

(2)  Bruker-Franzen will design and manufacture the Mass Spectrometer, meeting
     the specifications required for use in the DNA MassArray(TM) process and
     dedicated and appropriate to process Sequenom's Spectrochips(TM) ,
     including the XY-stage component and signal acquisition software. The
     parties will mutually agree on specifications for the Mass Spectrometer and
     the SpectroChip. Bruker will make available to Sequenom the complete
     details of the interface, including software protocols and time behavior,
     enabling Sequenom to develop the specific application DNA MassArray(TM)
     software.

(3)  The Mass Spectrometer will be available by June 30, 1998.

(4)  Bruker-Franzen and Sequenom will promote the Mass Spectrometer under a
     joint label. The procedure will be defined on a case-by-case basis.

(5)  Bruker-Franzen will market and provide service for the Mass Spectrometer on
     a world-wide scale and under the name of Bruker-Franzen and Sequenom.

(6)  Sequenom will provide nucleic acid analysis services to customers and to
     corporate partners using DNA MassArray(TM)
     Sequenom will provide DNA MassArray(TM) application development, including
     necessary software, to Mass Spectrometry users.
     Sequenom will develop, manufacture and market SepctroChips(TM) for whatever
     applications.

*** - Portions of this page have been omitted pursuant to Confidential Treatment
request and filed separately, with the Commission.

                                       2
<PAGE>

Business Terms

(1)  Bruker-Franzen will supply the Mass Spectrometer to the market at a
     competitive market price (the "Market Price").

(2)  Sequenom maintains the option to purchase from Bruker-Franzen the Mass
     Spectrometer *** (the "Supply Price"). The Supply Price will be calculated
     by ***, referring to the basic instrument, in the respective country of
     instrument delivery.

(3)  Bruker-Franzen Analytik will provide one Mass Spectrometer to Sequenom,
     Hamburg as ? test site by June 30, 1998 ***. Initially, a
     prototype instrument equipped for handling of a single SpectroChip (TM)
     will be supplied by March 30, 1998. The Modular System in Hamburg will be
     used as demonstration and test site by both parties.

     A second Mass Spectrometer will be supplied to Sequenom, San Diego, the
     price being the Supply Price, by June 30, 1998.

(4)  The Mass Spectrometer will be *** for the exclusive processing of
     Sequenom's SpectroChip(TM).


Timelines

(1)  The Collaboration Agreement will come into force with the date of
     signature.

(2)  The Collaboration agreement may be terminated by either party at 12 months
     notice; such first notice of termination may, however, not be given earlier
     than 30 Dec. 1999.


Date:     December 4, 1997                     Date:    December 4, 1997
     -------------------------                      ------------------------
Bruker-Franzen                                 Sequenom

/s/ Dr. Frazen                                 /s/ Dr. H. Koster
                                               (Dr. H. Koster)

/s/ ppa H.J. [illegible]

*** - Portions of this page have been omitted pursuant to Confidential Treatment
request and filed separately, with the Commission.

                                       3

<PAGE>

                                                                   EXHIBIT 10.30


               Contractual Agreement between Sequenom and GeSIM
               ------------------------------------------------
                            As of October 1, 1998.
                            ----------------------

PREAMBLE

GeSIM's field of work is the development, production and marketing of components
and complete device systems for the dosage and pipetting of nanoliter volumes
(GeSIM nanoliter technology, hereinafter NLT). In particular, this involves the
development, production and distribution of micro-pipettes and nanoliter
plotters for various applications.
Furthermore, GeSIM develops, produces and distributes silicon chips of different
geometry and surface treatments (GeSim chip technology, hereinafter CT).

Sequenom`s field of work is the development and utilization of procedures for
the analyses of bio-polymers using mass spectrometry to separate, detect and
characterize the sample(s) or analysis products. To this end they combine the
chip concept with protected solid phase chemistry and enzymes. Sequenom
distributes the complete automation of this process. One essential step in this
process is the loading of SpectroChips ("SpectroChip" = trademark), which
requires the use of NLT.

The field of application of this agreement involves the preparation of samples
for the analysis of ***.

The co-operation between GeSIM and Sequenom comprises the optimization and
integration of ***.

The optimization and integration results achieved for Sequenom, including system
solutions developed for Sequenom, are licensed *** to Sequenom.

The specifications of the nano-plotter as a characterization of the current NLT
system, which has been positively validated by Sequenom for its own purposes,
are listed in Appendix A. The optimization and integration results achieved
through this exclusive co-operation, including the system solution developed for
Sequenom, is listed in Appendix B.
Appendices A and B are updated regularly, at least quarterly.  Amendments by
GeSIM and SEQUENOM must be confirmed in writing.

*** Portions of this page have been omitted pursuant to Confidential Treatment
request and filed separately with the Commission.

                                    Page 1
<PAGE>

                                     (S) 1
                 Cooperation Goals of the Contractual Partners


(1)  The goal of Sequenom is to commercialize the technology for the analysis
     of *** as described in the Preamble, on the basis of their own patents and
     their own know-how. ***.
(2)  The goal of GeSIM is to produce, further develop and market device systems
     consisting of ***, which are developed, constructed and produced for
     Sequenom and the area of application directly associated with Sequenom, on
     the basis of GeSIM's own patents and own know-how.


                                     (S) 2
                                Confidentiality


(1)  As concerns all information, technical knowledge and experience which have
     been made available to the co-operating parties or which will be made
     available to them in the future by the other party in connection with this
     co-operation agreement, beginning December 2, 1997, the date of the initial
     negotiations, both parties are obligated:

     A)   to keep this information confidential and not to provide it to a third
       party, even if a confidential disclosure agreement has been signed;
     B)   not to use this information for commercial purposes without permission
       from the other party, and
     C)   to provide this information only to those persons at their own company
       who require it to carry out the agreed co-operation.


                                     (S) 3
                               *** Co-operation


(1)  This *** co-operation between SEQUENOM and GeSIM refers to the development
     work to be carried out by GeSIM on behalf of SEQUENOM and financially paid
     for by SEQUENOM. The basis of such development work is individual contracts
     for projects with clearly defined goals.

*** Portions of this page have been omitted pursuant to Confidential Treatment
request and filed separately with the Commission.

                                    Page 2
<PAGE>

(2)  The optimization and integration results accomplished for/with Sequenom in
     connection with this *** co-operation are *** for the use of SEQUENOM.
     The results compiled for/with SEQUENOM and for each individual area of
     application (`general' or `sample preparation' for *** are listed in
     Appendix B, in so far as the results are used for/by SEQUENOM. Appendix B
     shall be updated regularly, at least quarterly. Both parties shall jointly
     compile the descriptions and the definitions of the results listed in
     Appendix B.
(3)  In addition, GeSIM is obligated not to make the results and products and
     the associated know-how listed in Appendices A and B available to other
     producers of mass spectrometers or developers of technologies and methods
     for the analysis of ***.
(4)  GeSIM's responsibilities to co-operate *** with Sequenom, as listed
     under (S) 3.3, do not apply if Sequenom has not accepted or delivered ***.
(5)  SEQUENOM shall buy from GeSIM ***. As a contractual partner, Sequenom GmbH
     guarantees in connection with the above, that it is authorized to fulfill
     this obligation to GeSIM. This purchase obligation does not apply if GeSIM
     cannot provide these products and/or qualities under competitive conditions
     and in the necessary quantity.


                                     (S) 4
                              Delivery Guarantee


(1)  Within the contractual period, GeSIM guarantees for the unconditional
     availability of automatic nanoliter liquid handling modules or systems, as
     well as for silicon chips in accordance with the specifications in
     Appendices A and B.
(2)  GeSIM guarantees that all production specifications as noted in the Systems
     Manual shall at least be maintained, even in the case of further
     development. The specifications listed in Appendix B are considered an
     obligatory supplement to the Systems Manual.
(3)  Changes to the delivery products are allowed in the area of technical
     developments.

*** Portions of this page have been omitted pursuant to Confidential Treatment
request and filed separately with the Commission.

                                    Page 3
<PAGE>

                                     (S) 5
                                    Prices


(1)  GeSIM's price for the products delivered to Sequenom and Sequenom's clients
     should be under competitive conditions.
(2)  Sequenom shall receive from GeSIM a discount of *** for each additional
     nano-liter plotter ordered.


                                     (S) 6
                                Joint Marketing


     (1)     The nano-liter plotters and associated follow-up products developed
        through this co-operation can be marketed under the name and brand GeSIM
        and Sequenom.
     (2)     Sequenom will make an active contribution to the marketing
        activities of GeSIM both in terms of personnel and editorially for
        scientific presentations, conferences and exhibitions. Marketing
        materials for joint campaigns will be created together.


                                     (S) 7
                              Contractual Period


     (1)     This agreement is valid from now until December 31, 2001. The
        *** of the results granted to Sequenom as listed in Appendix B at the
        end of this contract continues on after the end of the contract.
     (2)     Both parties are free to extend the contract any time.
     (3)     Should the ownership of either one of the co-operating partners
        change during the duration of the contract, this will not affect the
        agreement in any way.

*** Portions of this page have been omitted pursuant to Confidential Treatment
request and filed separately with the Commission.

                                    Page 4
<PAGE>

                                     (S) 8
                                 Final Clause


(1)    The parties are not allowed to transfer the rights or duties of this
   agreement to any third party without the consent of the other party, unless
   otherwise specified in this contract.
(2)    This agreement replaces all other preceding arrangements or agreements
   concluded between the co-operating partners regarding the stipulations of
   this agreement. Changes and supplements to this agreement must be in written
   form, unless there is a legally stricter form. The written form also applies
   is the written form has been waived.
(3)    Should any of these regulations be found to be partially or completely
   legally ineffective, or lose their legal effectiveness or feasibility at a
   later time, the rest of the agreement shall remain unaffected. This also
   applies if the agreement is found to contain a loophole. The ineffective or
   non-feasible regulation or loophole is to be replaced by an appropriate
   regulation which comes as close to the original intentions of the co-
   operating partners as far is legally possible, or what they would have
   intended for the purpose and meaning of this agreement, if they had been
   aware of this point before concluding the contract.
(4)    The exclusive jurisdiction for all and any differences in connection with
   this agreement is Hamburg.

                                    Page 5
<PAGE>

APPENDIX A / Status: September 9, 1998

***

*** Portions of this page have been omitted pursuant to Confidential Treatment
request and filed separately with the Commission.

                                    Page 6

<PAGE>

APPENDIX B:

***

*** Portions of this page have been omitted pursuant to Confidential Treatment
request and filed separately with the Commission.

                                    Page 7

<PAGE>

                                                                  EXHIBIT 10.31

                               LICENSE AGREEMENT

Between

    PROF.  DR. FRANZ HILLENKAMP
    Bahlmannstr. 5, 48147 Munster, Germany

                                                     hereinafter the "Inventor"


And

    SEQUENOM, INC.
    11555 Sorrento Valley Road, San Diego, CA  92121, USA
    Represented by SEQUENOM GmbH, Mendelsohnstr. 15D,
    2276 Hamburg, FRG

                                                         hereinafter "SEQUENOM"


PREAMBLE

(1) Collaboration

    The Inventor has been acting as a consultant for SEQUENOM for several
years.  In respect of the main area of activity of SEQUENOM, the  *** , the
consulting on the part of the Inventor is *** (Annex 1, Consulting Agreement).

    The parties collaborate closely in the area of *** in the framework of
projects, which may be supported in part by third parties, among others BNBF.
These projects are or will be at least proportionately financed by SEQUENOM.

(2) Inventions and Proprietary Rights

    The Inventor  has made the inventions listed in Annex 2 in the area of
MALDI (Matrix Assisted Laser Desorption/Ionization) (Annex 2 makes no claim to
being complete).  Further inventions in the area of       ***      are
expected.
    The inventions are grouped into:
a)                                      ***
                                        ***
                                        ***
                                        ***

    *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

    The granting of licenses for the above-described existing and future patent
rights from the Inventor to SEQUENOM in the area of the above-described
collaboration is governed by the following Agreement.

(S) 1
CONTRACTUAL RIGHTS

(1) Area of work

    The Inventor in his capacity as a consultant to SEQUENOM collaborates
with SEQUENOM both (a) in the area of     ***    as well as (b) in the
performance of joint research and developmental work in the area of     ***
***    The term   ***              may be described in this context among other
things by the following parameters:

    -    ***
and
    -    ***

    In respect of the areas of work named under (a) and (b), the Inventor
collaborates with SEQUENOM as the     ***    commercial partner, i.e., licensee,
or together with SEQUENOM and additional partners, on condition that SEQUENOM
agrees to it.

(2) Contractual Rights

    Contractual Rights as defined by this agreement are present and future
patents applied for and/or granted and patentable results according to items a)-
c) of the preamble. The Inventor shall use best efforts to solely own the
intellectual property which was produced on his part under the terms of the
collaboration. In the event of joint inventions of co-workers of the Inventor
which are subject to the Law governing inventions of employees, the Inventor
shall within his sphere of influence see to it that the inventions are claimed
without restrictions and are transferred to SEQUENOM in accordance with the
conditions stipulated herein.

    Patents already applied for or granted under the terms of the collaboration
are listed in Annex 2 (Annex 2 makes no claim to being complete).

(S) 2
CONTRACTUAL KNOW-HOW

    The Inventor has extensive know-how in the technical field of the
Contractual Rights transferred hereby, and the collaboration agreed upon herein,
in particular in the preparation of samples and in the configuration and
operation of instrumentation and the interpretation of mass spectra. This know-
how is of essential importance for the practical implementation of the
Contractual Rights.


    *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                       2
<PAGE>

(S) 3
GRANTING OF RIGHTS

1.  The Inventor gives SEQUENOM a worldwide   ***  for the unlimited use of the
Contractual Rights and the Contractual Know-how. The license is limited to the
area of work as defined in (S) 1 (1).

    If it is not possible to grant an *** for the area of work because of the
general conditions (limitations) for the public promotion of research, or
because of other prior written agreements, if applicable, including third party
participants in the project, then the Contractual Rights transferred shall at
least cover the *** rights of use for SEQUENOM's essential area of *** (as
defined above).

(S) 4
CONTINUED DEVELOPMENT OF CONTRACTUAL RIGHTS

1.  The Inventor shall use best efforts within the scope of his research to
promote the future development of the Contractual Rights and to maintain the
technical lead over alternative developments.  The Inventor does not hereby
assume an obligation to undertake specific research measures (directions) or to
guarantee success.

2.  The Inventor shall include into the contractual relationships all new
developments resulting from his efforts in respect of the Contractual Rights,
the Contractual Know-how and the area of collaboration.  In particular, he shall
maintain the know-how at the latest state of development by regularly updating
the records with research and test results.  SEQUENOM shall have regular access
to the updated records.

(S) 5
GUARANTEE OF THE LICENSOR

    The Inventor/Licensor is not aware of any facts, in particular proprietary
rights, which preclude the use of existing Contractual Rights.  The Inventor,
however, does not assume liability therefor.  The Inventor shall rather
endeavor, together with SEQUENOM, to design around obstacles, if they preclude
the use of the Contractual Rights.

(S) 6
ROYALTIES

1.  For the granting of the described license for the Contractual Rights,
SEQUENOM shall pay to the Inventor a royalty in the amount of     ***     of the
net sales realized by SEQUENOM using the Contractual Rights - independently of
the number of Contractual Rights used. Sales are the proceeds - after receipt of
payment by SEQUENOM - from the sale of


    *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                       3
<PAGE>

products, which are based on Contractual Rights and/or the application of which
requires the use of the Contractual Rights, or services which are rendered using
the Contractual Rights.

2.  For sales that are realized using exclusively the Contractual Rights, which
result from the collaboration (see (S)1) of SEQUENOM and the Inventor, and in
which the Inventor or one of his co-workers is named as (co-)inventor, the
royalty is      ***    .

3.  In case the sum total of all royalties which SEQUENOM has to pay to third
parties exceeds the value of  ***   for given proceeds, the royalties payable to
the Inventor shall be                         ***              in order to
reduce it to exactly      ***     of the given proceeds.

4.  SEQUENOM refunds all expenses to the Inventor which he has incurred or
incurs in connection with applying for, maintaining and defending patents for
the Contractual Rights, provided that these Contractual Rights are transferred
 ***    to SEQUENOM. Included herein is the cost of applying for, maintaining
and defending patents in other countries. The parties to the agreement shall
discuss the procedures concerning patents matters as required. If licenses for a
given patent or a given patent application are granted to third parties for
areas of application which are not exclusive to SEQUENOM, then all expenses as
described above are shared as a rule proportionately by SEQUENOM and this
(these) third party (parties). Expenses already paid by SEQUENOM shall be
reimbursed proportionately by this (these) third party (parties). The Inventor
is thus obliged to transfer this obligation to possible third party licensees.
The Inventor shall also, by prior agreement, be reimbursed for expenses which
arise in connection with obtaining or reinstatement of patent right according to
Annex 2, paragraph 2.

5.  Royalties are always due at the end of a calendar year and after receipt of
payment for the underlying sales by SEQUENOM.

(S) 7
CONFIDENTIALITY

1.  The parties undertake mutually to keep confidential all information
exchanged or to be exchanged during the duration of this agreement and knowledge
acquired concerning fundamentals, developments, improvements and other details
in respect of the Contractual Rights and the Contractual Know-how as well as
matters regarding the execution of the agreement, even if they have not been
expressly designated as secret or confidential.  This does not apply, if the
disclosure is necessary to transfer the know-how to licensees in other areas of
the agreement or other areas of application, in order to obtain official
approvals, or to disclose the results obtained to the public or to professional
circles.

2.  Both parties undertake to impose this obligation of confidentiality on their
co-workers or employees, who because of their occupation can acquire useful
knowledge of the Contractual Rights and the Contractual Know-how.  This
obligation of confidentiality is to be imposed on the


    *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                       4
<PAGE>

staff also after termination of their employment contract or assistance
relationship as postgraduates or doctoral candidates.

3.  The Inventor undertakes to impose on other licensees corresponding
obligations for confidentiality in other areas of the agreement or areas of
application.

4.  This obligation of confidentiality continues beyond the duration of the
agreement.  It remains in effect until the know-how becomes public.

5.  The contracting parties shall inform each other in oral or written form
about planned publications which contain information according to (S) 7,
paragraph (1).  A time limit of 3 months shall be provided to the respective
party from the time of complete disclosure to publication for raising an
objection or for applying for relevant proprietary rights.  In case an objection
is raised, the parties shall try to reach a solution which is acceptable to both
sides.  An objection may only be raised or maintained for an important reason.

(S) 8
DURATION OF AGREEMENT

1.  The agreement ends at the end of the tenth calendar year after the first
calendar year for which licenses are paid according to its conditions unless it
is renewed at the latest six months before the end.

2.  Beyond that, the agreement ends automatically, if the royalties from
SEQUENOM to the Inventor are below the amount of DM 10,000.00 in two successive
calendar years. This provision may be applied by both parties at the earliest
three years after signing of the agreement.

3.  In case of termination of the agreement according to paragraph (2), all
rights and obligations concerning the Contractual Rights and the Contractual
Know-how revert back to the Inventor. If the Inventor realizes income from the
continued use of the patents or the know-how of this agreement from other
licensees, SEQUENOM shall receive a *** share but no more than the amount of
patent costs assumed by SEQUENOM.

(S) 9
FINAL PROVISIONS

1.  SEQUENOM has the right to grant sublicenses of the Contractual Rights. In
case of the granting of sublicenses, SEQUENOM shall have the obligation to
ensure that all rights of the Inventor resulting from this agreement are also
applicable to the sublicenses.

2.  The Inventor undertakes to maintain the Contractual Rights including
additional applications and the applications made in the course of the
agreement, as far as they


    *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                       5
<PAGE>

concern the area of the Contractual Rights or to offer them to SEQUENOM, and not
to assign them to third parties without SEQUENOM's consent.

3.  The agreement is subject to the written form.  Modifications require the
written form.  This is also applicable to this written form clause itself.

4.  Should individual provisions of this agreement be or become invalid or
unenforceable, the validity of the agreement shall otherwise not be affected;
the parties shall undertake to replace the invalid or unenforceable provision by
an effective amendment which comes closest to the commercial purpose of the
invalid or unenforceable provision.

5.  Place of jurisdiction is the residence or principle place of business of the
respective defendant(s) within the Federal Republic of Germany.


Munster, January 20, 1999                    San Diego/Hamburg, January 14, 1999


Prof. Dr. Franz Hillenkamp                   SEQUENOM, Inc.
                                             Prof. Dr. Hubert Koster
                                             President & CEO




                                             SEQUENOM, GmbH
                                             Dr. Toni Schuh
                                             Managing Director

                                       6
<PAGE>

ANHANG 1:  BERATERVERTRAG


Consulting Services Agreement as of October 4, 1996, by and between Franz
Hillenkamp, Sequenom, Inc., San Diego, and Sequenom GmbH, Hamburg.
<PAGE>

ANHANG 2



(1) With respect to intellectual property naming Franz Hillenkamp as inventor,
Sequenom, Inc. will file and prosecute all US patent applications,
continuations-in-part, continuations, divisionals and their foreign counterparts
including international PCT applications and any other foreign filings outside
the United States for the inventions, improvements and intellectual property
related to:

                                       ***
                                       ***
                                       ***
                                       ***
                                       ***


(2) Franz Hillenkamp ist Erfinder von Schutzrechten auf dem Gebiet der   ***
                                       ***
                                       ***
                                       ***


    *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                       8
<PAGE>

2.  Der Erfinder verpflichtet sich, die Vertragsrechte, einschlieBlich der
Zusatzanmeldungen und der im Laufe des Vertrages vorgenommenen Anmeldungen,
soweit sie den Bereich der Vertragsrechte betreffen, aufrechtzuerhalten bzw.
SEQUENOM anzubieten und sie nicht ohne Zustimmung von SEQUENOM an Dritte zu
ubertragen.

3.  Der Vertrag unterliegt der Schriftform. Anderungen bedurfen der Schriftform.
Dies gilt auch fur diese Schriftformklausel selbst.

4.  Sollten einzelne Bestimmungen dieses Vertrages unwirksam sein oder werden,
so beruhrt das die Wirksamkeit des Vertrages im ubrigen nicht; die Parteien
verpflichten sich vielmehr, die unwirksame Bestimmung durch eine wirksame
Regelung zu ersetzen, die dem wirtschaftlichen Zweck der unwirksamen Bestimmung
am nachsten kommt.

5.  Gerichtsstand ist der Wohn- bzw. Firmensitz der/des jeweilig Beklagten
innerhalb der Bundesrepublik Deutschland.



Munster, den 20.1.99                       San Diego/Hamburg, den 14 Januar 1999



 /s/ Franz Hillenkemp                        /s/ Hubert Koster
- --------------------------                 ---------------------------
Prof. Dr. Franz Hillenkamp                 SEQUENOM, Inc.
                                           Prof. Dr. Hubert Koster
                                           President & CEO



                                           /s/ Toni Schuh
                                           ----------------------------
                                           SEQUENOM, GmbH
                                           Dr. Toni Schuh
                                           Gechaftsfuhrer
<PAGE>

                         ADDENDUM TO LICENSE AGREEMENT
                         -----------------------------
                             AND PATENT ASSIGNMENT
                             ---------------------

    THIS ADDENDUM TO LICENSE AGREEMENT AND PATENT ASSIGNMENT (the "Addendum and

Patent Assignment") is made as of this 29st day of September 1999, by Professor

Dr. Franz Hillenkamp, an individual (the "Inventor"), and SEQUENOM, Inc., a

Delaware corporation ("SEQUENOM").

                                R E C I T A L S
                                ---------------

    A.   Dr. Hillenkamp and SEQUENOM have entered into a License Agreement dates

as of January 14, 1999 (the "License Agreement), pursuant to which SEQUENOM has

licensed from Dr. Hillenkamp, and Dr. Hillenkamp has licensed to SEQUENOM,

certain patents and now-how of Dr. Hillenkamp.

    B.   Dr. Hillenkamp and SEQUENOM desire to modify the License Agreement as

set forth in this Addendum and Patent Assignment.

    NOW, THEREFORE, for mutual consideration, Inventor and SEQUENOM agree as

    follows:

    1.   Assignment of the Inventions and Patent Rights of the Inventor.
         ---------------------------------------------------------------
Inventor does hereby assign to SEQUENOM, it successors and assigns, all of

Inventor's right, title and interest in and to the Inventions and Patent Rights

as set forth in the patents and patent applications set forth below (the

"Patents"):

                                  ***
                                  ***
                                  ***
                                  ***

    *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

    2.   Execution of Documents. Inventor shall execute formal assignment
         -----------------------
documents specific to each patent or patent application which will be recorded

with the United States Patent and Trademark Office and other patent offices as

appropriate.

    3.   Reversionary Assignments. Upon the occurrence of any of the following
         -------------------------
conditions, SEQUENOM hereby agrees to reassign to Inventor, his successors and

assigns, that portion of SEQUENOM's right, title and interest in and to all

subject matter claimed in any patents issuing from        ***       continuation

and divisional applications thereof, and patents worldwide claiming priority

from       ***                            ***                       The

conditions of such reassignment are expressly limited to:

                                        ***
                                        ***
                                        ***
                                        ***

    4.   Successors and Assignees. This Addendum and Patent Assignment is
         -------------------------
executed pursuant to the License Agreement and is entitled to the benefits

thereof and shall be binding upon and inure to the benefits of the Inventor and

SEQUENOM and their respective successors and assigns.

    5.   Sublicense.                     ***
         -----------
                                         ***

    6.   Effect of Addendum and Patent Assignment.  In the event of a conflict
         -----------------------------------------
between the terms of License Agreement and the terms of this Addendum and Patent

Assignment, the terms of the Addendum and Patent Assignment shall prevail.


    *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                       2
<PAGE>

    7.   Definitions.  All capitalized terms used herein and not otherwise
         -----------
defined in the Addendum and Patent Assignment shall have the meanings attributed

to them in the License Agreement.

    IN WITNESS WHEREOF, Inventor and SEQUENOM have executed this Addendum and

    Patent Assignment on the date first above written.

                                INVENTOR:



                                /s/ Franz Hillenkamp
                                -----------------------------------
                                Professor Dr. Franz Hillenkamp



                                SEQUENOM:

                                SEQUENOM, Inc.



                                /s/ Hubert Koster
                                ------------------------------------
                                Professor Dr. Hubert Koster
                                President and Chief Executive Officer



                                SEQUENOM:

                                SEQUENOM, GmbH.



                                /s/ Toni Schuh
                                -------------------------------------
                                Dr. Toni Schuh
                                Managing Director


                                       3
<PAGE>

                                ACKNOWLEDGEMENT



STATE OF CALIFORNIA    )
                       )ss.
COUNTY OF              )

    On this   ____ day of June 1999, before me, _______________________, the

undersigned Notary Public, personally appeared _______________ personally known

to me (or proved to me on the basis of satisfactory evidence) to be the person

who executed the above and foregoing ADDENDUM TO LICENSE AGREEMENT AND PATENT

ASSIGNMENT.

    WITNESS my hand and official seal.



                                             ____________________________

                                             Notary Public in and for said State


                                       4

<PAGE>

                                                                   EXHIBIT 10.32

                               SUPPLY AGREEMENT

                                by and between

                        Tactical Fabs, Inc. ("Seller")
                               51 Whitney Place
                              Freemont, CA 94539

                                      and

                           SEQUENOM, Inc. ("Buyer")
                           11555 Sorrento Valley Rd
                           San Diego, CA 92121-1331


This Agreement dated April 1, 1999 (the "Execution Date") is by and between
SEQUENOM, Inc., a corporation organized and existing under the laws of the State
of California and having its principal office at 11555 Sorrento Valley Road, San
Diego, California 92121-1331 ("Buyer"), and Tactical Fabs, Inc., a corporation
organized and existing under the laws of the State of California and having its
principal office at 51 Whitney Place, Fremont, CA 94539 ("Seller").

                                 INTRODUCTION

The parties agree that the Seller shall design, manufacture and supply chips
("DIE") as specified by Buyer under this Agreement.  Seller and Buyer in
addition agree to work cooperatively to further pursue the development of DIE
for applications in mass spectrometry.

NOW, THEREFORE, in consideration of the foregoing premises and the mutual
promises and covenants set forth below, Seller and Buyer mutually agree as
follows:

                            Article 1.  DEFINITIONS

When used in this Agreement, each of the following, terms shall have the
meanings set forth in this Article I:

SECTION 1.1    "Affiliate" means any corporation, company, partnership, joint
venture and/or firm which controls, is controlled by, or is under common control
with a specified person or entity.  For purposes of this Section 1.1, "control"
shall mean (a) in the case of corporate entities, direct or indirect ownership
of at least fifty percent (50%) of the stock or shares having the right to vote
for the election of directors, and (b) in the case of non-corporate entities,
direct or indirect ownership of at least fifty percent (50%) of the equity
interest with the power to direct the management and policies of such non-
corporate entities.


Confidential                        Page 1
<PAGE>

SECTION 1.2    "Agreement" shall mean this Supply Agreement, as amended from
time to time.

SECTION 1.3    "Delivery Date" shall mean a date for which delivery of Product
is properly requested in a purchase order.

SECTION 1.4    "Initial Term" shall have the meaning set forth in Section 5. 1.

SECTION 1.5    "Party" means Buyer or Seller; "Parties" means Buyer and Seller.
As used in this Agreement, references to "third parties" do not include a Party
or its Affiliates.

SECTION 1.6    "Product" shall mean each product supplied hereunder by Seller in
its completed and functional form and that is listed in and meets in all
material respects the specifications set forth in Exhibit I, attached hereto and
made a part hereof, as such Exhibit is amended by the parties from time to time.

SECTION 1.7    "Change of Control" means a merger, consolidation, sale or other
transfer of all or substantially all of the assets of either Party to a third
party.

SECTION 1.8    "Confidential Information" means all materials, know-how or other
information, including, without limitation, proprietary information and
materials (whether or not patentable) regarding a Party's technology, products,
business information or objectives, which is designated as confidential in
writing by the disclosing Party, whether by letter or by the use of an
appropriate stamp or legend, prior to or at the time any such material, trade
secret or other information is disclosed by the disclosing Party to the other
Party.  Notwithstanding the foregoing to the contrary, materials, know-how or
other information which is orally, electronically or visually disclosed by a
Party, or is disclosed in writing without an appropriate letter, stamp or
legend, shall constitute Confidential Information of a Party (a) if the
disclosing Party, within thirty (30) days after such disclosure, delivers to the
other Party a written document or documents describing the materials, know-how
or other information and referencing the place and date of such oral, visual,
electronic or written disclosure and the names of the persons to whom such
disclosure was made, or (b) such information is of the type that is customarily
considered to be confidential information by persons engaged in activities that
are substantially similar to the activities being engaged in by the Parties
hereunder.  Notwithstanding the foregoing, any technical or financial
information of a Party disclosed at a meeting of Seller and the Buyer or
disclosed through an audit or royalty reports shall constitute Confidential
Information of a Party unless otherwise specified.

SECTION 1.9    "Executive Officers" means the Chief Executive Officer of Buyer
(or an executive of Buyer designated by such Chief Executive Officer) and the
Chief Executive Officer of Seller (or an officer of Seller designated by such
Chief Executive Officer).

SECTION 1.10   ADDITIONAL DEFINITIONS.  Each of the following definitions set
forth in the section of this Agreement indicated below:

DEFINITION SECTION

Confidential                                                                   2
<PAGE>

"Breaching Party" "Extension Period" "Intellectual Property" "Non-Breaching
Party" "Notification" "Response Period" "Software Developments" "Specified
Process Technology" "Termination Date" "Backorder"

                   Article 2. SALE AND PURCHASE OF PRODUCTS

SECTION 2.1    SALE AND PURCHASE.  Seller, within the limitations contained in
this Article, agrees to exclusively sell to Buyer such quantities of Product as
Buyer may order in accordance herewith.  Subject to the provisions of Section
4.1 and 5.1 hereof, so long as this Agreement shall remain in effect, Buyer
agrees, for itself, its Affiliates and sublicensees, to satisfy solely through
Buyer's purchase of Products under this Agreement   ***   of Buyer's and Buyer's
Affiliates' and sublicensees' requirements of Product or any other products with
the characteristics that meet the specifications as described in Exhibit I
("Requirements").

It is understood that Seller shall have the right in connection with supply
hereunder to subcontract with third parties as Seller deems advisable to
manufacture Product, provided, however, that Seller shall remain fully
responsible hereunder and the subcontractors are bound by the terms and
conditions hereunder.

SECTION 2.2    QUANTITY; FORECASTS.

A.   Buyer and Seller will mutually agree within thirty (30) days of signing
     this Agreement, an initial order volume and the first delivery date.  Buyer
     at this time will provide a reasonable best estimate of the next three
     quarter's forecast for the Product.

B.   Commencing on the second year of this Agreement, Buyer will provide Seller
     a forecast of Buyer's quantity requirements for such Product for at least
     the next four (4) full calendar quarters.  Thereafter, Buyer shall deliver
     to Seller at or prior to the end of each calendar quarter, Buyer's firm
     order for such Product for the second calendar quarter following such
     calendar quarter and a forecast of its quantity requirements for such
     Product for the three (3) following calendar quarters.

C.   Commencing in the second year of this Agreement, the amount of any Product
     forecasted for delivery in the first of the three calendar quarters
     forecasted of year two of this Agreement shall be ***
          *** of the most recent previous forecast for such a quarter.

D.   After the first year of this Agreement the total amount of each Product
     ordered by Buyer for delivery in any calendar quarter for which an order is
     required may  ***
          **     of Buyer's most recent forecast of its requirements for
     such Product for such quarter. In addition, Seller's supply obligation will
     not extend    ***
          ***     of Buyer's most recent forecast of its requirements for
     such

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     Product for such quarter. If a Buyer Product requirement for any quarter
     exceeds *** of Buyer's most recent forecast of it requirements for such
     Product for such calendar quarter, Seller and Buyer will discuss in good
     faith the additional amount, if any, that Seller is willing to supply
     consistent with its other obligations and Buyer will adjust its order
     accordingly. Buyer shall indemnify Seller and reimburse it promptly upon
     request for all reasonable out of pocket costs and expenses, including the
     cost of carrying increased inventory, to the extent caused by any deviation
     in order quantities from the limits imposed by the preceding sentence, and
     Seller will act reasonably to mitigate any such costs and expenses.

SECTION 2.3    TECHNOLOGY CHANGE

        *

SECTION 2.4    BACKORDERS.

A.   Backorders are defined as orders that have not been fully received at the
     Buyer within the guaranteed order lead time.

B.   Backorders must show an approximate shipping date and indicate the reason
     for such backorder.

C.   The Seller is required to provide any backorders without service or
     delivery charges.

D.   It is the responsibility of the Seller to manage backorders and provide the
     Buyer, at no additional cost, with required product to ensure stock-outs do
     not occur.

E.   The Seller will be in default if the Product is backordered for more than
     ten (10) working days, or if the Buyer feels that the approximate shipping
     date provided by the Seller for the backordered Product(s) jeapordizes the
     Buyer's commercial operations and the operation of its Customers.

     (i)  In case of default, and after notifying the Seller, Buyer may obtain
          the same quantity of the Product from other suppliers.

     (ii) The Seller will be responsible, for the cost difference between the
          Product and the Product from other suppliers.

SECTION 2.5    DELIVERY.

A.   Delivery will be Free On Board (FOB) the Buyer's receiving dock and will
     include delivery, packaging, and unloading costs.  The Buyer will not
     assume any of these costs.

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B.      Include all costs in the quoted unit price.

*    Seller agrees the terms of this Agreement may be renegotiated upon written
     notice from Buyer, with such renegotiated terms to take effect no sooner
     than 90 days after such initial notice from Seller to Buyer, if, in the
     opinion of the Buyer, the Product provided by the Seller has been displaced
     by other technologies; provided however, Buyer shall afford Seller a
     reasonable opportunity to supply alternative technology.

C.      Seller will package the Products in accordance with the specifications
        set forth in Exhibit I hereto. Seller will include with each shipment
        copies of all applicable quality and testing records.

SECTION 2.6    REJECTION OF PRODUCT IN CASE OF NONCONFORMITY.

A.      Buyer may reject any portion of shipment of Product that does not
        conform to the specifications contained in Exhibit I. In order to reject
        a shipment, Buyer must (i) give notice to Seller of Buyer's intent to
        reject the shipment within ten (10) days of receipt together with a
        detailed written indication of the reasons for such possible rejection,
        and (ii) as promptly as reasonably possible thereafter, provide Seller
        with notice of final rejection and the full basis thereof. After notice
        of intent to reject is given, Buyer shall cooperate with Seller in
        determining whether rejection is necessary or justified. If no such
        notice of intent to reject is timely received, Buyer shall be deemed to
        have accepted such delivery of Product, provided, however, in the case
        of Products having latent defects which upon diligent examination by
        Buyer could not have been discovered, Buyer must give notice of Buyer's
        intent to reject within thirty (30) days after discovery of such
        defects, provided that such notice may in no event be given later than
        ninety (90) days after receipt of the shipment. In any event, Buyer
        shall pay for the shipment as otherwise provided herein and shall be
        entitled to a refund of the purchase price (together with insurance and
        freight charges if applicable) of properly rejected Products at the time
        they are ultimately rejected. Seller shall notify Buyer as promptly as
        reasonable possible whether it accepts Buyer's basis for any rejection.

B.      Whether or not Seller accepts Buyer's basis for rejection, promptly on
        receipt of a notice of rejection, Seller shall use its reasonable
        efforts, at Buyer's request to provide replacement Product which shall
        be purchased by Buyer as provided in this Agreement.

C.      Unless Seller requests the return of the rejected batch within sixty
        (60) days of receipt of buyer's notice of rejection, Buyer shall destroy
        such batch promptly and provide Seller with certification of such
        destruction. Buyer shall, upon receipt of Seller's request for return,
        promptly dispatch said batch to Seller, at Seller's cost.

                         Article 3. PRICE AND PAYMENTS

SECTION 3.1    PRICE.  The price Buyer shall pay to Seller for Product purchased
hereunder is as indicated in Exhibit II. Prices shall be negotiated on a annual
basis between the two parties with price negotiations commencing no later than
three (3) months prior to the

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anniversary date and completed no later than two (2) months prior to the
anniversary date of this Agreement.

SECTION 3.2    Prices quoted in Exhibit II are net costs, in United States
dollars.  Federal Tax and State Sales Tax extra, where applicable.  Duty and
brokerage costs, if applicable are to be included in unit prices.

SECTION 3.3    CURRENCY AND METHOD OF PAYMENTS; LATE PAYMENTS.  All payments
under this Agreement shall be made in United States dollars by wire transfer to
such bank account as Seller may designate from time to time within no more than
ten (10) days when such payment is due. Buyer shall pay interest to Seller on
the aggregate amount of any payments that are not paid on or before the date
such payments are due under this Agreement at a rate per annum equal to ***
as reported by Seller's bank from time to time calculated on the number of days
such payment is delinquent.

                      ARTICLE 4.  ANNUAL BUSINESS REVIEW

SECTION 4.1    Within thirty (30) days of the anniversary date of this Agreement
both Parties shall meet to review the performance of each party under this
Agreement and if necessary outline steps to improve performance.

                        Article 5. PARTIAL TERMINATION

SECTION 5.1    TERMINATION OF PURCHASE OBLIGATIONS; FAILURE TO DELIVER.  In
addition to any termination of this Agreement under Article 6 hereof, this
Agreement shall terminate as to a particular Product as follows:

A.   If at any time after the Initial Term (as defined in Section 5.1) Buyer
     notifies Seller that Buyer has received a written good faith firm quote
     from a reputable third party supplier of recognized standing (other than an
     Affiliate) to supply Buyer for a period of
                                   ***
                                   ***       Seller shall have sixty (60) days
     after receipt of such notice to notify Buyer that Seller intends or does
     not intend to reduce its then applicable transfer price of such Product to
     a price       ***
          ***      upon the expiration of such sixty (60) day period. If Seller
     fails to give such notice or notifies Buyer that it does not intend to so
     reduce its then applicable transfer price of such Product, Buyer may, upon
     thirty (30) days' prior notice to Seller, elect to terminate its
     obligations hereunder to purchase, and Seller's obligations to supply, such
     Product. Notwithstanding the foregoing, Buyer shall have no rights under
     this Section 4.1 (A) if the third-party quote is given in connection with
     or in anticipation of some other relationship with the Buyer.

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B.   If Seller fails to timely deliver *** of the amount of any Product ordered
     by Buyer as required hereunder for any reason, excluding force majeure, as
     measured over any period of ninety (90) or more consecutive days, then
     Buyer may upon twenty (20) days' prior notice to Seller elect to terminate
     Buyer's obligations to purchase, and Seller's obligation to supply, such
     Product hereunder.

              Article 6. TERMINATION, RIGHTS AND OBLIGATIONS UPON
                                  TERMINATION

SECTION 6.1    TERM. Unless terminated for any particular Product pursuant to
Sections 5.1(A) or 5.1(B) hereof or by either party pursuant to the other
provisions of this Article 6, this Agreement shall continue in effect until
three (3) years from the date of First Commercial Sale of the first Product
supplied hereunder (the "Initial Term"), and shall thereafter remain in effect
until terminated by either Party upon at least ninety (90) days prior written
notice to the other Party.

SECTION 6.2    TERMINATION FOR DEFAULT.  If either party materially defaults in
the performance of any material Agreement, condition or covenant of this
Agreement and such default or noncompliance shall not have been remedied, or
steps initiated to remedy the same to the other party's reasonable satisfaction,
within ninety (90) days (or 10 days in the case of non-payment) after receipt by
the defaulting party of a notice thereof from the other party, the party not in
default may terminate this Agreement.

SECTION 6.3    RIGHTS AND OBLIGATIONS ON EXPIRATION OR TERMINATION.  Except to
the extent expressly provided to the contrary, the following provisions shall
survive the termination of this Agreement:  this Section 6.3 and Articles 7
through 10.  Any rights of Seller to payments accrued through termination as
well as obligation of the parties under firm orders for purchase and delivery of
Products at the time of such termination shall remain in effect, except that in
the case of termination under Section 6.2, the terminating party may elect
whether obligations under firm orders will remain in effect, except that Seller
will have no obligation with respect to Delivery Dates more than six (6) months
after termination.

                          Article 7. CONFIDENTIALITY

SECTION 7.1    CONFIDENTIAL INFORMATION.  All Confidential Information disclosed
by a Party to any other Party during the term of this Agreement shall not be
used by the receiving Party except in connection with the activities
contemplated by this Agreement, shall be maintained in confidence by the
receiving Party (except to the extent reasonably necessary for regulatory
approval of products developed by Buyer, Seller or any of their respective
Affiliates), and shall not otherwise be disclosed by the receiving Party to any
other person, firm, or agency, governmental or private, without the prior
written consent of the disclosing Party, except to the extent that the
Confidential Information (as determined by competent documentation):

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A.   was known or used by the receiving Party prior to its date of disclosure to
     the receiving Party; or

B.   either before or after the date of the disclosure to the receiving Party is
     lawfully disclosed to the receiving Party by sources other than the
     disclosing Party rightfully in possession of the Confidential Information;
     or

C.   either before or after the date of the disclosure to the receiving Party
     becomes published or generally known to the public (including information
     known to the public through the sale of products in the ordinary course of
     business) through no fault or omission on the part of the receiving Party
     or its sublicensees; or

D.   is independently developed by or for the receiving Party without reference
     to or reliance upon the Confidential Information; or

E.   is required to be disclosed by the receiving Party to comply with
     applicable laws, to defend or prosecute litigation or to comply with
     governmental regulations, PROVIDED THAT the receiving Party provides prior
     written notice of such disclosure to the disclosing Party and takes
     reasonable and lawful actions to avoid and/or minimize the degree of such
     disclosure, PROVIDED THAT, specific information shall not be deemed to be
     within any of these exclusions merely because it is embraced by more
     general information falling within these exclusions.

SECTION 7.2    EMPLOYEE AND ADVISOR OBLIGATIONS.  Seller and Buyer each agree
that they shall provide Confidential Information received from any of the other
Parties only to their respective employees, consultants and advisors, and to the
employees, consultants and advisors of such Party's Affiliates, who have a need
to know and have an obligation to treat such information and materials as
confidential.

SECTION 7.3    COMPETITION.  Seller agrees that for the term or the Agreement
and for a period of three (3) years after the expiration of the Agreement,
Seller shall not share, contract or make available for purposes of sale, any
information, technology, process technology and/or product technology developed
under this Agreement by either party with its customers or potential customers
that are either manufacturers of mass spectrometers or companies that perform or
intend to perform biopolymer analysis using mass spectrometry.

SECTION 7.4    EQUITABLE RELIEF.  Seller acknowledges and agrees that due to the
unique nature of Buyer's Proprietary Information, there can be no adequate
remedy at law for any breach of its obligations hereunder, that any such breach
may allow Seller or third parties to unfairly compete with Buyer resulting in
irreparable harm to Buyer, and therefore, that upon any such breach or threat
thereof, Buyer shall be entitled to injunctions and other appropriate equitable
relief in addition to whatever remedies it may have at law.

SECTION 7.5    TERM.  All obligations of confidentiality imposed under this
Article 7 shall continue for a period of at least five (5) years following
termination or expiration of this Agreement.

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                   Article 8. REPRESENTATIONS AND WARRANTIES

SECTION 8.1    REPRESENTATION OF AUTHORITY; CONSENTS.  Seller and Buyer each
represent and warrant to the other Parties that as of the Execution Date it has
full right, power and authority to enter into this Agreement, this Agreement has
been duly executed by such Party and constitutes a legal, valid and binding
obligation of such Party, enforceable in accordance with its terms, and all
necessary consents, approvals and authorizations of all government authorities
and other persons required to be obtained by such Party in connection with the
execution, delivery and performance of this Agreement have been and shall be
obtained.

SECTION 8.2    NO CONFLICT.  Each Party represents to the other Parties that
notwithstanding anything to the contrary in this Agreement, the execution and
delivery of this Agreement and the performance of such Party's obligations
hereunder (a) do not conflict with or violate such Party's Articles of
Incorporation and Bylaws or any requirement of applicable laws or regulations
and (b) do not and shall not conflict with, violate or breach or constitute a
default or require any consent under, any contractual obligation of such Party.

SECTION 8.3    KNOWLEDGE OF PENDING OR THREATENED LITIGATION.  Each Party
represents and warrants to the other Parties that there is no claim,
investigation, suit, action or proceeding pending or, to the knowledge of such
Party, expressly threatened, against such Party before or by any governmental
entity or arbitrator that, individually or in the aggregate, could reasonably be
expected to (i) have a material adverse effect on such Party, (ii) materially
impair the ability of such Party to perform any obligation under this Agreement
or (iii) prevent or materially delay or alter the consummation of any or all of
the transactions contemplated hereby.

SECTION 8.4    EMPLOYEE AND CONSULTANT OBLIGATIONS.  Each Party represents and
warrants that all of its employees, officers, and consultants have executed
agreements or have existing obligations under law requiring, in the case of
employees and officers, assignment to such Party of all inventions made during
the course of and as the result of their association with such Party and, in the
case of employees, officers and consultants, obligating the individual to
maintain as confidential such Party's Confidential Information as well as
confidential information of a third party which such Party may receive, to the
extent required to support such Party's obligations under this Agreement.

SECTION 8.5    FULL DISCLOSURE.  Each Party has disclosed to the other Parties
in good faith, all material information such Party believes is relevant to the
subject matter of this Agreement, and to such Party's ability to observe and
perform its obligations hereunder.

SECTION 8.6    WARRANTIES.  Seller warrants to Buyer that, when shipped to Buyer
by Seller, the Products will conform in all respects to the specifications set
forth in Exhibit I, as then in effect, and (ii) will not be adulterated.
BUYER'S SOLE AND EXCLUSIVE REMEDY FOR ANY BREACH OF THE FOREGOING WARRANTIES OR
FOR PRODUCT DEFECTS SHALL BE ITS RIGHT UNDER SECTIONS 2.6 AND 9.1 HEREOF OR
REPLACEMENT OF OR, AT SELLER'S OPTION OF IF REPLACEMENT IS IMPRACTICAL, REFUND
FOR RETURNED NONCONFORMING UNITS OF PRODUCT PROVIDED TO SELLER WITHIN

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THREE (3) MONTHS AFTER THE ORIGINAL NONCONFORMING UNITS (BUT NOT REPLACEMENTS)
ARE SHIPPED BY SELLER. EXCEPT FOR THE FOREGOING WARRANTIES, SELLER DOES NOT
WARRANT THE MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE OF THE PRODUCTS
OR THE PERFORMANCE OR NONINFRINGEMENT THEREOF, DOES NOT MAKE ANY WARRANTY,
EXPRESS OR IMPLIED, WITH RESPECT TO PRODUCTS, SPECIFICATIONS, SUPPORT, SERVICE
OR ANYTHING ELSE AND DOES NOT MAKE ANY WARRANTY TO BUYER'S CUSTOMERS OF AGENTS.
SELLER HAS NOT AUTHORIZED ANYONE TO MAKE ANY REPRESENTATION OR WARRANTY OTHER
THAN AS PROVIDED ABOVE. THE FOREGOING LIMITATIONS OF WARRANTIES SHALL NOT IN ANY
WAY LIMIT BUYER'S RIGHTS UNDER SECTION 9.1 THEREOF.

                      Article 9. MISCELLANEOUS PROVISIONS

SECTION 9.1    PRODUCT LIABILITY INDEMNIFICATION.

A.   BUYER.  Buyer agrees to defend Seller and its affiliates at Buyer's cost,
     and will indemnify and hold Seller and their respective directors,
     officers, employees and agents ("the Seller Indemnified Parties") harmless
     from and against any losses, costs, damages, fees or expenses arising out
     of any claim relating to (i) any breach by Buyer of any of their respective
     representations, warranties or obligations pursuant to this Agreement, or
     (ii) personal injury from the use, sale or other disposition of any product
     or service offered by Buyer and/or its respective licensees or
     collaborators.  In the, event of any such claim against the Seller
     Indemnified Parties by any third party, Seller shall promptly notify Buyer
     in writing of the claim and Buyer shall manage and control, at their sole
     expense, the defense of the claim and Buyer shall manage and control, at
     their sole expense, the defense of the claim and its settlement.  The
     Seller Indemnified Parties shall cooperate with Buyer and may, at their
     option and expense, be represented in-any such action or proceeding.  Buyer
     shall not be liable for any litigation costs or expenses incurred by the
     Seller Indemnified Parties without Buyer's prior written authorization.  In
     addition, Buyer shall not be responsible for the indemnification of any
     Seller Indemnified Party arising from any negligent or intentional acts by
     such party.

B.   SELLER.  Seller agrees to defend Buyer and its Affiliates at Seller's cost,
     and will indemnify and hold Buyer and their Affiliates and their respective
     directors, officers, employees and agents (the "Buyer Indemnified Parties")
     harmless from and against any losses, costs, damages, fees or expenses
     arising out of any claim relating to (i) any breach by Seller of any of its
     representations, warranties or obligations pursuant to this Agreement or
     (ii) personal injury from the development or manufacture of an Product.
     Provided however, Seller shall have no indemnity obligations for any
     personal injury claims arising after delivery of the Product to Buyer, or
     arising out of the use or sale of the Product by Seller or its licenses or
     collaborators.  In the event of any claim against the Buyer Indemnified
     Parties by any third party, Buyer shall promptly notify Seller in writing
     of the claim and Seller shall manage and control, at its sole expense, the
     defense of the claim and its settlement.  The Buyer Indemnified Parties
     shall cooperate with Seller and may, at their option and expense, be
     represented in any such action or

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     proceeding. Seller shall not be liable for any litigation costs or expenses
     incurred by the Buyer Indemnified Parties without Seller's prior written
     authorization. In addition, Seller shall not be responsible for the
     indemnification of any Buyer Indemnified Party arising from any negligent
     or intentional acts by such party.

SECTION 9.2    GOVERNING LAW.  This Agreement shall be construed and the
respective rights of the Parties hereto determined according to the substantive
laws of the State of California notwithstanding the provisions governing
conflict of laws under such California law to the contrary, except matters of
intellectual property law which shall be determined in accordance with the
national intellectual property laws relevant to the intellectual property in
question.

SECTION 9.3    ASSIGNMENT.  Neither Seller, on one hand, nor Buyer, on the
other hand, may assign this Agreement in whole or in part without the consent of
the other, except if such assignment occurs in connection with the sale or
transfer of all or substantially all of the business and assets of Seller, on
the one hand, or Buyer, on the other, to which the subject matter of this
Agreement pertains.  Notwithstanding the foregoing, any Party may assign its
rights (but not its obligations) pursuant to this Agreement in whole or in part
to an Affiliate of such Party.

SECTION 9.4    AMENDMENTS.  This Agreement constitutes the entire agreement
between the Parties with respect to the subject matter hereof, and supersedes
all previous arrangement with respect to the subject matter hereof, whether
written or oral.  Any amendment or modification to this Agreement shall be made
in writing signed by both Parties.

SECTION 9.5    NOTICES.

     Notices to Buyer shall be addressed to:

     Sequenom, Inc.
     11555 Sorrento Valley Rd
     San Diego, CA 91212-1331

     Attention: Chief Executive Officer
     Facsimile No.: (619) 350-0344

     Notices to Seller shall be addressed to:

     Tactical Fabs, Inc.
     51 Whitney Place
     Freemont, CA 94539

     Attention: Chief Executive Officer
     Facsimile No.: (510) 770-8879

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     Any Party may change its address by giving notice to the other Parties in
     the manner herein provided.  Any notice required or provided for by the
     terms of this Agreement shall be in writing, and shall be (a) sent by
     registered or certified mail, return receipt requested, postage prepaid,
     (b) sent via a reputable overnight courier service, or (c) sent by
     facsimile transmission, in each case properly addressed in accordance with
     the paragraph above.  The effective date of notice shall be the actual date
     of receipt by the Party receiving the same.

SECTION 9.6    FORCE MAJEURE.  No failure or omission by the Parties hereto in
the performance of any obligation of this Agreement shall be deemed a breach of
this Agreement or create any liability if the same shall arise from any cause or
causes beyond the control of the Parties, including, but not limited to, the
following: acts of God; acts or omissions of any government; any miles,
regulations or orders issued by any governmental authority or by any officer,
department, agency or instrumentality thereof; fire; storm; flood; earthquake;
accident; war; rebellion; insurrection; riot; and invasion and provided that
such failure or omission resulting from one of the above causes is cured as soon
as is practicable after the occurrence of one or more of the above-mentioned
causes.

SECTION 9.7    PUBLIC ANNOUNCEMENTS.  Any announcements or similar publicity
with respect to the execution of this Agreement shall be agreed upon among the
Parties in advance of such announcement.  All Parties understand that this
Agreement is likely to be of significant interest to investors, analysts and
others, and that any of the Parties therefore may make such public announcements
with respect thereto.  The Parties agree that any such announcement will not
contain confidential business or technical information and, if disclosure of
confidential business or technical information is required by law or regulation,
will make reasonable efforts to minimize such disclosure and obtain confidential
treatment for any such information which is disclosed to a governmental agency
or group.  Each Party agrees to provide to the other Parties a copy of any
public announcement as soon as reasonably practicable under the circumstances
prior to its scheduled release.  Except under extraordinary circumstances, each
Party shall provide the other with an advance copy of any press release at least
five (5) business days prior to the scheduled disclosure.  Each Party shall have
the right to expeditiously review and recommend changes to any announcement
regarding this Agreement or the subject matter of this Agreement.  Except as
otherwise required by law, the Party whose press release has been reviewed shall
remove any information the reviewing Party reasonably deems to be inappropriate
for disclosure.

SECTION 9.8    DEPENDENT CONTRACTORS.  It is understood and agreed that the
relationship between the Parties hereunder is that of independent contractors
and that nothing in this Agreement shall be construed as authorization for
either Seller, on the one hand, or Buyer, or the other hand, to act as agent for
the other.

SECTION 9.9    NO STRICT CONSTRUCTION.  This Agreement has been prepared jointly
and shall not be strictly construed against any Party.

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SECTION 9.10   HEADINGS.  The captions or headings of the sections or other
subdivisions hereof are inserted only as a matter of convenience or for
reference and shall have no effect on the meaning of the provisions hereof.

SECTION 9.11   NO IMPLIED WAIVERS; RIGHTS CUMULATIVE.  No failure on the part
of Seller, on the one hand, or Buyer on the other hand, to exercise, and no
delay in exercising, any right, power, remedy or privilege under this Agreement,
or provided by statute or at law or in equity or otherwise, shall impair,
prejudice or constitute a waiver of any such right, power, remedy or privilege
or be construed as a waiver of any breach of this Agreement or as an
acquiescence therein, nor shall any single or partial exercise of any such
right, power, remedy or privilege preclude any other or further exercise thereof
or the exercise of any other right, power, remedy or privilege.

SECTION 9.12   SEVERABILITY.  If any provision hereof should be held invalid,
illegal or unenforceable in any respect in any jurisdiction, then, to the
fullest extent permitted by law, (a) all other provisions hereof shall remain in
full force and effect in such jurisdiction and shall be liberally construed in
order to carry out the intentions of the Parties as nearly as may be possible
and (b) such invalidity, illegality or unenforceability shall not affect the
validity, legality or enforceability of such provision in any other
jurisdiction.  To the extent permitted by applicable law, Seller and Buyer
hereby waive any provision of law that would render any provision hereof
prohibited or unenforceable in any respect.

SECTION 9.13   EXECUTION IN COUNTERPARTS.  This Agreement may be executed in
counterparts, each of which counterparts, when so executed and delivered, shall
be deemed to be an original, and all of which counterparts, taken together,
shall constitute one and the same instrument.

SECTION 9.14   THIRD PARTY BENEFICIARIES.  No person or entity other than Buyer,
Seller and their respective Affiliates and permitted assignees hereunder shall
be deemed an intended beneficiary hereunder or have any right to enforce any
obligation of this Agreement.

                       Article 10. INTELLECTUAL PROPERTY

SECTION 10.1   INTELLECTUAL PROPERTY.  Seller represents and warrants to Buyer
that as of the Execution Date:

     (i)  it is not aware of any claim made against it asserting the invalidity,
          misuse, unregistrability, unenforceability or non-infringement of any
          of its intellectual property which is the subject of this Agreement
          (the "Intellectual Property") or challenging its right to use or
          ownership of any of the Intellectual Property or making any adverse
          claim of ownership thereof;

     (ii) it is not aware of any pending, or threatened claim or litigation
          which alleges that Seller's activities to date relating to the
          Intellectual Property have violated, or by conducting its business as
          currently proposed to be conducted hereunder would violate, the
          intellectual property rights of any other person;

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     (iii) to the best of Seller's knowledge, there has been no infringement or
           misappropriation by a third party of any of the Intellectual
           Property;

     (iv)  to Seller's knowledge, its activities to date have not infringed or,
           by conducting its business as proposed to be conducted hereunder
           would not infringe, any of the intellectual property rights of any
           other person.; and

     (v)   all Seller Process Technology Patent Rights or Seller Product
           Technology Patent Rights are owned by Seller or, to Seller's
           knowledge, are validly licensed to Seller, provided, however, that in
           no event shall this subsection (v) be interpreted as a representation
           or warranty that the Seller Process Technology or Seller Product
           Technology does not infringe or misappropriate intellectual property
           rights of any third party.

SECTION 10.2   PATENT AND PRODUCT RIGHTS.  Title to inventions, developments or
discoveries arising from co-operation conducted under the Supply Agreement shall
be determined in accordance with United States Patent Law, Title 35 United
States Code.

A.   Buyer Inventions - All rights to inventions or discoveries made solely by
     Buyer shall belong to Buyer and shall be disposed of in accordance with
     Buyer policy.

B.   Seller Inventions - All rights to inventions or discoveries made solely by
     Seller shall belong to the Seller and shall be disposed of in accordance
     with Seller policy.

C.   Joint Inventions - All rights to inventions or discoveries made jointly by
     Seller and Buyer shall be jointly-owned.

To the extent that the Seller has the legal right to do so, the Seller shall
offer to the Buyer, in accordance with the provisions of the following
paragraph, a time-limited first right to negotiate a commercial, royalty-bearing
license, to make, use, and sell any Seller or Joint Invention conceived and
first actually reduced to practice in the performance of research under this
Supply Agreement and having an application in *** for the term of any patent
thereon.

The Seller shall disclose to the Buyer any inventions, process technologies and
product technologies arising under this Supply Agreement.  The Buyer shall hold
such disclosure on a confidential basis and will not disclose the information to
any third party without consent of the Seller.

                    Article 11.  EXTENSION OF INITIAL TERM

The Parties acknowledge that they may find it to be mutually beneficial to
continue the relationship established by this Agreement after the termination of
the Initial Term.

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

Confidential                                                                  14
<PAGE>

Consequently, the Parties hereby agree to negotiate in good faith, prior to six
(6) months before the expiration of the Initial Term, whether or not to extend
the Initial Term an terms and conditions that are mutually acceptable to the
Parties.

                       Article 12.  APPROVAL/SIGNATURES

This Agreement shall inure to the benefit of and shall be binding upon the
parties hereto, and their respective successors and permitted assigns.

IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed
by their duly authorized representatives as of the day and year first above
written.


Sequenom, Inc.                               Tactical Fabs, Inc.


By /s/ Hubert Koster                        By /s/ Gerald G. Henderson
   ------------------------------             ---------------------------------
Name (Print)  Hubert Koster, PhD.           Name (Print) Gerald G. Henderson
            ---------------------                       -----------------------
Title President & CEO                       Title President
     ----------------------------                ------------------------------

Confidential                                                                  15
<PAGE>

                        Exhibit I Product Specification


See attached

Confidential                                                                  16
<PAGE>

                                    DIAGRAM


                                      ***
     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

Confidential                                                                  17
<PAGE>

                          EXHIBIT II PRODUCT PRICING:


Production cost for the "D" Chip in quantities at die level.

QTY ***                       QTY ***                       QTY ***

    ***                           ***                           ***

Wafers and process to be purchased in *** Shipping will be pre-paid and added.
Payment terms are Net 30 days.

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

Confidential                                                                  18

<PAGE>

                                                                EXHIBIT 10.33

                        OEM SUPPLY & LICENSE AGREEMENT

This Agreement made this 15th day of June, 1999 ("Effective Date") is by and
between PerSeptive Biosystems, Inc., a Division of the PE Biosystems Business of
PE Corporation ("PerSeptive"), a Delaware corporation with a place of business
at 500 Old Connecticut Path, Framingham, MA 01701 and Sequenom, Inc.
("Sequenom"), a Delaware corporation with a place of business at 11555 Sorrento
Valley Road, San Diego, CA 92121.

                                   RECITALS

    PerSeptive has expertise in the development and manufacture of mass
spectrometry instrument workstations (the "Mass Spec Products"), and desires to
manufacture and sell to Sequenom Mass Spec Products.

    Sequenom is desirous of purchasing certain Mass Spec Products from
PerSeptive for incorporation into system products to be sold by Sequenom, and in
connection with such sale to obtain from PerSeptive rights to market and resell
PerSeptive's Mass Spec Products to Sequenom's Customers.

    PerSeptive is willing to supply Mass Spec Products to Sequenom and to grant
Sequenom rights to resell such products as part of its system product offering,
all in accordance with the terms and conditions set forth in this Agreement.

    Based on the foregoing recitals and in consideration of the mutual
covenants and promises herein contained, the parties agree as follows:

1.  DEFINITIONS  For purposes of this Agreement and all Exhibits attached
    -----------
hereto, the following terms shall have the meaning set forth below:

    1.1  "Affiliate" means with respect to either Party a person or entity,
    including without limiting the generality of the foregoing, corporations,
    partnerships and joint ventures, that directly or indirectly through one or
    more intermediaries, controls, is controlled by or is under common control
    with such person or entity.  "Control" (and, with correlative meanings, the
    term "controlled by" and "under common control with") means the possession
    of the power to direct or cause the direction of the management and
    policies of such person or entity, whether through the ownership of voting
    stock, by contract or otherwise.  In the case of a corporation, "control"
    shall mean, among other things, the direct or indirect ownership of fifty
    percent (50%) or more of its outstanding voting stock.

    1.2  "Agreement" means this OEM Agreement, as amended from time to time.

    1.3  "Agreement Year" means any twelve month period during the term of this
    Agreement commencing on the Effective Date or any anniversary date thereof.

    1.4  "Backorders" has the meaning set forth in Section 5. 1.

                                       1
<PAGE>

    1.5  "Confidential Information" means all materials, know-how or other
    information, including, without limitation, proprietary information and
    materials (whether or not patentable) regarding a Party's technology,
    products, business information or objectives, which is designated as
    confidential in writing by the disclosing Party, whether by letter or by
    the use of an appropriate stamp or legend, prior to or at the time any such
    material, trade secret or other information is disclosed by the disclosing
    Party to the other Party. Notwithstanding the foregoing to the contrary,
    materials, know-how or other information which is orally, electronically or
    visually disclosed by a Party, or is disclosed in writing without an
    appropriate letter, stamp or legend, shall constitute Confidential
    Information of a Party (a) if the disclosing Party, within thirty (30) days
    after such disclosure, delivers to the other Party a written document or
    documents describing the materials, know-how or other information and
    referencing the place and date of such oral, visual, electronic or written
    disclosure and the names of the persons to whom such disclosure was made,
    or (b) such information is of the type that is customarily considered to be
    confidential information by persons engaged in activities that are
    substantially similar to the activities being engaged in by the Parties
    hereunder. Notwithstanding the foregoing, any technical or financial
    information of a Party disclosed by PerSeptive to Sequenom or visa versa or
    disclosed through an audit or sales report shall constitute Confidential
    Information of a Party unless otherwise specified.

    1.6  "Customer" means the end-user customer who purchases a Sequenom system
    that includes Product(s).

    1.7  "Cutoff period" has the meaning set forth in Section 4.3.

    1.8  "Delivery Date" means the date on which delivery of Product(s) is
    properly requested in a Purchase Order and accepted by PerSeptive.

    1.9  "Discount Recapture" has the meaning set forth in Section 3.3.

    1.10  "Intellectual Property Rights" has the meaning set forth in Section
    4.11.

    1.11  "Invoice" means a PerSeptive in voice issued to Sequenom in
    accordance with the terms of this Agreement.

    1.12  "Party" means Sequenom or PerSeptive; "Parties" means Sequenom and
    PerSeptive.  As used in this Agreement, references to "third parties" means
    persons or entities other than a Party or its Affiliates.

    1.13  "Products" means the current, specific Mass Spec Products identified
    by PerSeptive's part numbers listed on Exhibit 2.1 attached hereto, a
    general description of which is set forth opposite each such part number,
    including the licenses required for the operation of the Products as
    outlined in Section 13.  Products shall also include any such products as
    changed or modified by PerSeptive in a manner that does not substantially
    alter the form, fit or function of any such product.

                                       2
<PAGE>

    1.14  "Projected Quantity" has the meaning set forth in Section 3.2.

    1.15  "Purchase Order" means a Sequenom purchase order issued to PerSeptive
    in accordance with the terms of this Agreement.

    1.16  "Release date" has the meaning set forth in Section 4.3.

    1.17  "Specifications" means information specifying the technical and
    performance criteria for Products that is published in PerSeptive's
    Standard Operating Procedure (SOP) documents in effect on the date Products
    are shipped in response to a Purchase Order.  Upon request, PerSeptive will
    provide such documents to Sequenom under the confidentiality provisions of
    Section 15.

    1.18  "Trademarks" means PerSeptive's trademarks, logos, trade dress, etc.
    which are affixed either to the Products or on the packages/containers in
    which such Products are shipped, or which are included in written materials
    relating to or mentioning the Products.

2.  PRICE
    -----

    2.1  Exhibit 2.1 attached hereto sets forth the current published retail
    prices ("List Price") for the Products and related installation and support
    services and license fees, and the net sales price payable by Sequenom.
    PerSeptive agrees to provide Products and services to Sequenom at prices
    which reflect a discount        ***
         ***            from List Price as more fully set forth in Exhibit 2.1.
    PerSeptive shall provide Sequenom with at least ninety (90) days notice
    of any pricing changes that may occur from time to time during the term of
    this Agreement.  Sequenom shall pay to PerSeptive for each Product ordered
    pursuant to this Agreement an amount equal to the retail list price of such
    Product, as set forth on the Exhibit 2.1 in effect at the time the order is
    received by PerSeptive, less the discount applicable to such Product set
    forth on Exhibit 2. 1.

    2.2  Prices given in Exhibit 2.1 are exclusive of, and Sequenom shall be
    responsible for the payment of, shipping charges (including freight and
    insurance customs fees, installation, field service maintenance and support
    (unless field service occurs within the warranty period), extended
    warranty, as well as any applicable sales, use, service, value added and
    similar taxes.

3.  DISCOUNTS
    ---------

    3.1  To qualify for the discounts set forth in Exhibit 2.1, Sequenom agrees
    to purchase      ***       Products having      ***
          ***      (a "System Product") over the three-year term of this
    Agreement.


*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                       3
<PAGE>

    3.2  Subject to the provisions of Section 4, on the Effective Date and on
    or before three (3) months prior to the end of an Agreement Year, Sequenom
    will issue a Purchase Order for the number of System Products that Sequenom
    intends to purchase in the coming year.  For each Agreement Year, the
    projected quantity of System Products to be purchased by Sequenom
    ("Projected Quantity") is as follows:

         Year 1    ***  Products
         Year 2    ***  Products
         Year 3    ***  Products

    3.3  To maintain the discount from list price of the Products as set forth
    in Exhibit 2.1, Sequenom must order for delivery in any Agreement Year no
    less than   ***                             ***  of the Projected Quantity
    ("Required Purchases").  If in any Agreement Year Sequenom does not meet its
    quota of Required Purchases, the discount provided Sequenom shall be reduced
    *** *** ***     Such reduction in discount shall remain in effect until such
    time as Sequenom shall have ordered in accordance with the terms of this
    Agreement and released for delivery a sufficient quantity of System Products
    to make up the prior year(s) deficiency(ies) and satisfy the current year's
    pro rata Required Purchases.

    3.4  Notwithstanding the provisions of Section 3.3, and subject to the last
    sentence of this Section 3.4, all Invoices issued with respect to orders
    for delivery placed by Sequenom under this Agreement shall reflect the
    applicable discount set forth in Exhibit 2. 1.  However, the dollar amount
    equal to the Discount Recapture, if any, will be calculated by PerSeptive,
    and notice thereof provided to Sequenom, within forty five (45) days after
    the end of each Agreement Year, with any such amount being carried forward
    from year to year during the term of this Agreement.  At the end of the
    second Agreement Year, PerSeptive will invoice Sequenom for any Discount
    Recapture due, and Sequenom agrees to pay such invoice within thirty (30)
    days of its issuance.  If by the end of the second Agreement Year Sequenom
    has ordered and released for delivery less than *** System Products,
    PerSeptive may in its sole discretion discontinue or modify the discounts
    set forth in Exhibit 2.1 on all future orders placed by Sequenom during the
    term of this Agreement.

    3.5  Notwithstanding any provision to the contrary as may be contained
    herein, if at the end of the third Agreement Year Sequenom shall not have
    ordered and released for delivery   ***  System Products, it shall be
    obligated to purchase from PerSeptive within the next ninety (90) days that
    number of System Products equal to the difference between the number of
    System Products actually ordered by Sequenom and   *** at a fully discounted
    price equal to the discounted price set forth in Exhibit 2.1


*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                       4
<PAGE>

4.  ORDERS
    ------

    4.1  Orders for the purchase of Products hereunder shall be submitted to
    PerSeptive on a Purchase Order and shall specifically reference this
    Agreement.  All orders are subject to acceptance by PerSeptive, which shall
    not be unreasonably withheld.  All terms and conditions of sale of Products
    are set forth in this Agreement.  In the event of a conflict between the
    terms and conditions of this Agreement and the terms and conditions on a
    Purchase Order or Invoice, the terms and conditions of this Agreement shall
    prevail except for terms of a Purchase Order specifically designated by
    PerSeptive as terms that supercede the inconsistent terms in this
    Agreement.

    4.2  Upon acceptance of a Purchase Order, PerSeptive shall use commercially
    reasonable efforts to manufacture the Products in accordance with the
    Specifications and to ship such Products in accordance with the delivery
    requirements and Delivery Dates set forth in Section 6.

    4.3  Purchase Orders will include the quantities and types of Products to
    be purchased by Sequenom during the coming year together with an estimated
    schedule of when such Products are to be released for delivery ("release
    date").  Except for Products scheduled to be released within a rolling
    three (3) month period from any calendar date (the "cutoff period"),
    Sequenom may adjust the quantity, type and release date of the Products
    listed on the Purchase Order at its discretion.  The quantity and type of
    Products scheduled to be released within the cutoff period can not be
    altered.

    4.4  PerSeptive's supply obligation hereunder will not extend to more that
    ***        *** of Sequenom's Projected Quantity of Products for the year in
    question. If Sequenom's Product requirements for any quarter exceeds *** of
    Sequenom's Projected Quantity of Products, PerSeptive and Sequenom will
    discuss in good faith the additional amount, if any, that PerSeptive is
    willing to supply consistent with its other obligations and Sequenom will
    adjust its order accordingly. Sequenom shall reimburse PerSeptive promptly
    upon request for all reasonable out of pocket costs and expenses, including
    the cost of carrying increased inventory, to the extent caused by any
    deviation in order quantities from the limits imposed by the preceding
    sentence, and PerSeptive will act reasonably to mitigate any such costs and
    expenses.

    4.5  PerSeptive agrees to use its commercially reasonable efforts to
    provide Sequenom with notice ninety (90) days in advance of (i) any changes
    to the Products listed in Exhibit 2.1 that alter the form, fit or function
    of the Product or (ii) the discontinuance of any Product.  PerSeptive
    reserves the right in its sole and absolute discretion to modify the form,
    fit or function of any Product, or to otherwise modify any Product, and to
    discontinue the manufacture of any Product except for Products which have
    been discontinued PerSeptive shall remain obligated to fill orders as have
    been placed by Sequenom that are subject to accepted Purchase Orders.
    Sequenom reserves the right to terminate this contract with no penalty with
    sixty (60) day written notice should the

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                       5
<PAGE>

    Products change significantly thereby rendering the Products incompatible
    with Sequenom's products or should the change adversely effect Sequenom's
    ability to sell its products. Notwithstanding any such termination, Sequenom
    shall remain obligated to purchase all Products subject to Purchase Orders
    issued by Sequenom.

    4.6  Sequenom hereby grants to PerSeptive and PerSeptive reserves a
    purchase money security interest in each Product purchased hereunder, and
    in any proceeds thereof, for all amounts owing to PerSeptive for or related
    to the product.  Upon request by PerSeptive, Sequenom shall sign any
    document required for PerSeptive to perfect such security interest.
    Payment in full of the purchase price of any Product purchased hereunder
    shall release the security interest on that Product.

    4.7  PerSeptive shall ship in accordance with PerSeptive's standard
    practices.  Sequenom may specify different shipping instructions, subject
    to agreement by PerSeptive, provided that Sequenom will be subject to an
    additional charge if the alternate method increases the cost of shipping
    equal to the increased cost.

    4.8  Unless otherwise agreed to in writing by PerSeptive, all Products
    shall be packed, if appropriate, for shipment and storage in accordance
    with PerSeptive's standard practices.  All packing shall conform to
    requirements of carrier's tariffs.

    4.9  All Products are subject to PerSeptive's standard tolerances for
    specifications.  PerSeptive reserves the right to make substitutions and
    modifications in the Specification of any Product, provided that such
    substitutions or modifications do not materially affect the performance of
    the Products.

    4.10  All patents, copyrights, trade secrets and other intellectual
    property rights (collectively, "Intellectual Property Rights") in or
    related to the Products sold hereunder are and will remain the exclusive
    property of PerSeptive or its licensors.  Sequenom shall not hereby acquire
    any Intellectual Property Rights in the Products except as expressly set
    forth in this Agreement.

    4.11  PerSeptive does not warrant the validity or enforceability of any
    Intellectual Property Rights relating to any Products.  PerSeptive warrants
    and represents, however, that at the time of the sale it is not aware of
    any infringement of any patents or patent applications or other
    Intellectual Property Rights owned by third parties which would prevent
    Sequenom from using or selling the Products.

    4.12  PerSeptive shall have the sole and exclusive right to evaluate any
    suit, claim or proceeding brought against Sequenom alleging that a Product
    purchased by Sequenom from PerSeptive and sold hereunder infringes any
    Intellectual Property Rights of others and to take any and all legal action
    PerSeptive shall deem appropriate with respect thereto.  PerSeptive will
    pay any cost of damages finally awarded against Sequenom in any such
    action.  Sequenom shall have the right to participate and be represented in
    any such suit by its own counsel at its own expense, but Sequenom shall not
    agree to, and PerSeptive shall have no liability for, any settlement,
    compromise or dismissal of such

                                       6
<PAGE>

    suit, or costs incurred in connection therewith, without PerSeptive's
    consent. Should the use of any Products by Sequenom be enjoined, or if
    PerSeptive believes that the use of the Products may infringe the
    Intellectual Property Rights of others, PerSeptive may, at its option,
    require Sequenom to discontinue the use of the allegedly infringing Product
    and shall either (i) substitute an equivalent non-infringing Product, (ii)
    modify the Product so that it no longer infringes but remains equivalent,
    (iii) obtain for Sequenom, at PerSeptive's own expense, the right to
    continue use of such Product, or (iv) refund the purchase price for such
    Product. At PerSeptive's request, Sequenom shall promptly return the Product
    to PerSeptive, at PerSeptive's expense. The foregoing states the entire
    liability of PerSeptive for Intellectual Property Right infringement.

5.  BACKORDERS
    ----------

    5.1  Backorders are defined as orders for System Products (excluding any
    piece, spare or similar component parts) that have not been fully received
    at the designated delivery point within the guaranteed order lead-time,
    subject to Section 6.1 below.

    5.2  Backorders must show an approximate shipping date and indicate the
    reason for such backorder.

    5.3  PerSeptive is required to provide any backorders without any extra
    service or delivery charges.

    5.4  It is the responsibility of PerSeptive to manage backorders and
    provide Sequenom, at no additional cost, with the required Products
    designated in a Purchase Order and to ensure their timely delivery.

         (i)  In case of default, and after notifying PerSeptive, Sequenom may
    obtain the equivalent Products from other suppliers.

         (ii) PerSeptive will be responsible, for the cost difference between
    the Products and the Products from other suppliers.

    5.5  PerSeptive will be in default if the Products are backordered for more
    than ten (10) working days, or if Sequenom feels that the approximate
    shipping date provided by PerSeptive for the backordered Product(s)
    jeopardizes Sequenom's commercial operations and the operation of its
    Customers.

6.  DELIVERY
    --------

    6.1  PerSeptive shall use commercially reasonable efforts to deliver
    Products to Sequenom on or within five (5) business days after the Delivery
    Dates set forth in Purchase Orders accepted by PerSeptive.  Unless
    PerSeptive otherwise agrees, all Delivery Dates shall be ninety (90) days
    or more from the date the Purchase Order is delivered to PerSeptive.

                                       7
<PAGE>

    6.2  In the event circumstances of force majeure as defined in Section 19.1
    exist which would prevent or delay delivery of Products by PerSeptive,
    PerSeptive shall have the right to apportion Products available for
    delivery among its various customers.

7.  SHIPMENT AND RISK OF LOSS
    -------------------------

    7.1  All Products delivered pursuant to the terms of this Agreement shall
    be F.O.B. PerSeptive manufacturing Plant, freight and insurance prepaid and
    added to the invoice, to Sequenom's address or other place of delivery as
    designated time to time by Sequenom, provided, however, that if delivery is
    requested to a site other than Sequenom's address set forth in Section 18,
    Sequenom shall be responsible to qualify delivery to such other site by
    specifying in sufficient detail to PerSeptive all of the necessary shipping
    and installation requirements for such site.  Sequenom shall indemnify and
    hold PerSeptive harmless, including the reimbursement of all reasonable
    expenses incurred by PerSeptive, as a result of Sequenom's failure to
    properly qualify delivery.  Sequenom shall use its best efforts to assist
    PerSeptive in arranging any desired insurance (in amounts that Sequenom
    shall determine) and transportation, via airfreight unless otherwise
    specified in writing, to any destinations specified in writing from time to
    time.  All customs, duties, costs, taxes, insurance premiums, and other
    expenses relating to such transportation and delivery shall be at
    Sequenom's expense.

    7.2  Title, with the exception of certain technology that is licensed to
    Sequenom as provided in this Agreement, and risk of loss with respect to
    all Products shall pass from PerSeptive to Sequenom upon transfer to the
    carrier.

8.  INSTALLATION AND ACCEPTANCE
    ---------------------------

    8.1  Installation of Products by PerSeptive may be purchased by Sequenom at
    the time of issuance of a Purchase Order by including a statement that
    installation by PerSeptive of the designated Product is requested, or at
    any other time.  If a Purchase Order with installation by PerSeptive
    included is accepted by PerSeptive, PerSeptive shall install the Product,
    in accordance with PerSeptive's then standard installation practice, at the
    Customer location or Sequenom's location, as designated on the Purchase
    Order or as otherwise agreed.  The cost of installation for the Product in
    question will be included on the Purchase Order and may be invoiced by
    PerSeptive with the invoice for the Product, or when installation by
    PerSeptive is otherwise agreed to, may be separately invoiced by
    PerSeptive, at PerSeptive's discretion.  PerSeptive will use commercially
    reasonable efforts to schedule and complete installation in a timely
    fashion.  PerSeptive and Sequenom will cooperate with each other to
    coordinate each other's installation efforts.

    8.2  For Products installed by PerSeptive, PerSeptive shall have no
    obligation to integrate the Product with any product of Sequenom, who shall
    be solely responsible for system integration.

    8.3  For Products installed by PerSeptive, installation shall be complete,
    and acceptance by Sequenom shall occur, when the Product passes
    PerSeptive's standard

                                       8
<PAGE>

    installation and test procedures in effect at the time of installation. For
    Products that are not installed by PerSeptive, acceptance by Sequenom occurs
    upon shipment and will be deemed to have occurred unless Sequenom
    demonstrates within thirty (30) days after delivery that the Product does
    not pass PerSeptive's standard installation and test procedures or satisfy
    the applicable Specifications, in which case acceptance occurs when such
    procedures are passed. Sequenom shall notify PerSeptive in writing of its
    rejection of the Product, specifying in sufficient detail the nature of the
    problem, and shall await PerSeptive's instructions with regard to
    disposition of the rejected Product which shall come no less than forty
    eight (48) hours after receiving the notification. PerSeptive shall use its
    reasonable best efforts to either repair on-site or off site, or, at its
    option, to replace the rejected Product with conforming Product. In any
    event, a Product that passes PerSeptive's standard installation and test
    procedures shall be at the Customer's facility as soon as commercially
    feasible. PerSeptive will use its reasonable commercial efforts to provide a
    Product that passes such tests no later than ten (10) working days after the
    initial Product failed the installation and test procedures. If instructed
    by PerSeptive, and upon receipt by Sequenom of a return authorization from
    PerSeptive, Sequenom shall ship back to PerSeptive any defective Product or
    any component thereof at Sequenom's cost. PerSeptive shall ship any
    replacement product back to Sequenom or the Customer at PerSeptive's cost.
    Refund including any freight and insurance costs incurred for authorized
    returned Products, repair or replacement shall be Sequenom's remedy for any
    rejection of any Product. Products may not be returned to PerSeptive under
    any circumstances without PerSeptive's prior written authorization. Any
    Product not repairable on-site and returned hereunder to PerSeptive may be
    conformed to comply with the Specifications at PerSeptive's facilities and
    thereafter used to fill a future Sequenom order.

9.  TRAINING
    --------

    9.1  PerSeptive commits to train, tuition free, two (2) designated Sequenom
    employees in the installation and routine maintenance of the Products.  The
    training will be conducted concurrently in a single class of two (2) weeks
    duration at PerSeptive's facility as part of PerSeptive's standard training
    programs and will be scheduled and executed within one hundred twenty (120)
    days of the Effective Date.  Sequenom may request from time to time due to
    employee changes or increased customer demand, and PerSeptive shall grant,
    additional training of the type set forth above.  The training will be
    scheduled on a mutually agreed upon basis and shall be invoiced to Sequenom
    at a rate of                        ***

10. PAYMENT
    -------

    10.1  Upon or after delivery of the Product to the F.O.B. point, PerSeptive
    shall submit an Invoice therefor.  Sequenom agrees to pay the amount of
    Invoices submitted by PerSeptive within thirty (30) days from date of
    Invoice.

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                       9
<PAGE>

    10.2  If payment is not received by the due date, a service charge may be
    added at the rate of 1.5 % per month (18% per year) or the maximum legal
    rate, whichever is less, to unpaid invoices from the due date thereof.
    Sequenom agrees to pay such service charges and agrees to reimburse
    PerSeptive reasonable attorney's fees and other out of pocket expenses of
    collection if PerSeptive engages counsel and/or incurs expenses to collect
    overdue amounts.

    10.3  In the event that Sequenom shall fail to pay any past due Invoice
    within ten (10) days of receipt of notice from PerSeptive, PerSeptive may,
    at any time and in its sole discretion, limit or cancel the credit of
    Sequenom as to time and amount, and as a consequence, may demand full
    payment or partial payment before delivery of any unfilled Purchase Order
    of this Agreement, and may demand assurance of Sequenom's due performance.
    Upon making such demand, PerSeptive may suspend production, shipment,
    and/or deliveries.  If, within the period stated in such demand, but in no
    event longer than thirty (30) days, Sequenom fails to agree and comply with
    such different terms of payment, and/or fails to give adequate assurance of
    due performance, PerSeptive may (i) by notice to Sequenom, treat such
    failure or refusal as a repudiation by Sequenom of the accepted Purchase
    Orders not then fully performed, whereupon PerSeptive may cancel all
    further deliveries and any amounts unpaid hereunder shall immediately
    become due and payable; or (ii) make shipments under reservation of a
    security interest and demand payment against tender of documents of title.

11. RESALE RESTRICTIONS
    -------------------

    11.1  PerSeptive hereby grants a right to Sequenom to resell the Products,
    bundled with the Sequenom system as described in Section 1 1.2, only to
    locations      ***
     ***
     ***
     ***
     ***      . If a location other than those listed above is designated as the
    place of installation on a Purchase Order accepted by PerSeptive, the
    parties shall be deemed to have agreed on such other location.

    11.2  It is the intention of the parties that this Agreement represents a
    value added resale business relationship.  Accordingly, Sequenom's resale
    of Products shall be in conjunction with other Sequenom products,
    ***
     ***.  Sequenom shall have no right to resell any Product purchased
    hereunder as a stand-alone Mass Spec Product, and any attempt to do so
    shall be deemed a material breach of this Agreement by Sequenom for which
    there is no right of cure, notwithstanding anything contained in this
    Agreement to the contrary.

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                       10
<PAGE>

    11.3  As set forth in Section 15.1, the price of Products payable by
    Sequenom pursuant to this Agreement is Confidential Information of
    PerSeptive, and Sequenom shall not furnish such price in any quote of any
    Sequenom system that includes a Product, or quote other items separately so
    that such price can be deduced, or otherwise disclose such price to any
    third party.

12. WARRANTY
    --------

    12.1  PerSeptive warrants that the Products will conform to the
    Specifications at the time of delivery and will be free from defects in
    materials and workmanship for a period of six (6) months.  The warranty
    period begins on the date of installation if the Products are installed by
    PerSeptive, but in no event later than thirty (30) days after shipment, or
    otherwise on the date of delivery.  The foregoing warranties do not include
    periodic maintenance or calibration recommended for some Products, unless
    specifically covered in the express written warranty terms, if any,
    accompanying the delivery of such Products.  To the extent then generally
    available to PerSeptive customers, Sequenom may purchase extended support
    coverage or a service contract on Products purchased pursuant to this
    Agreement at PerSeptive's then applicable retail rate, less    ***   .


    12.2  If PerSeptive receives notice of defects or nonconformance to the
    Specifications during the warranty period, PerSeptive will, at its option,
    repair (and recalibrate o *** nly as necessitated by repairs) or replace
    the affected Products.  If PerSeptive is unable, within the times
    designated in Section 12.6, to repair, replace or correct a defect or non-
    conformance in a Product to a condition as warranted, Sequenom will be
    entitled to a refund of the purchase price upon prompt return of the
    Product to PerSeptive.  PerSeptive will pay expenses for shipment of both
    defective and repaired or replacement Products.

    12.3  The above warranties do not apply to defects resulting from improper
    or inadequate maintenance or calibration by Sequenom or its Customers;
    Sequenom or third party supplied hardware or software, interfacing or
    supplies; unauthorized modification; improper use or operation outside of
    the Specifications for the Product; abuse, negligence, accident, loss or
    damage in transit; improper site preparation; or unauthorized maintenance
    or repair.

    12.4  Sequenom's sole remedies under PerSeptive's warranty shall be limited
    to repair or replacement of the Product that failed to conform to such
    warranty, or refund of the purchase price of the Product.  Repair,
    replacement or refund shall be at the sole discretion of PerSeptive.

    12.5  THE FOREGOING WARRANTIES ARE EXCLUSIVE AND NO OTHER WARRANTY, EXPRESS
    OR IMPLIED, IS GIVEN BY PERSEPTIVE, INCLUDING THOSE OF MERCHANTABILITY OR
    FITNESS FOR A PARTICULAR PURPOSE, ALL OF WHICH ARE EXPRESSLY DISCLAIMED.

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                       11
<PAGE>

    12.6  All Product defects or suspected defects during the warranty period
    will be managed by an authorized Sequenom representative (who has undergone
    training as provided in Section 9) who shall place a call to PerSeptive's
    designated service center followed up with the description of the Product
    problem in sufficient detail as to allow PerSeptive to assess the source of
    the problem.  All service calls placed by Sequenom will be responded to
    either by fax or by phone within two (2) business days with a proposed
    remedy to the Customer's problem being determined by PerSeptive as soon as
    commercially feasible after Sequenom's initial service call.  PerSeptive
    will use its reasonable commercial efforts to see to it that the Customer's
    Product is either fully operational or that a replacement instrument is
    delivered to the Customer if it is determined that an on-site repair is not
    possible with the allotted time within ten (10) business days of the
    initial service call.  Any Product not repairable on-site and returned
    hereunder to PerSeptive may be conformed to comply with the Specifications
    at PerSeptive's facilities and thereafter used to fill a future Sequenom
    order.

13. LICENSE RIGHTS
    --------------

    13.1  The Products purchased pursuant to this Agreement are described and
    claimed in one or more of the following U.S. Patents:
    ***                      , as well as in corresponding foreign patents and
    patent applications        ***        .  The price of each Product includes
    ***                  of its list price,                  ***
    ***          ***
    ***          ***
    and to extend such license solely to those Customers of Sequenom who
    purchase such Product as part of a Sequenom system.  Any such sublicense
    extended to its Customers by Sequenom as provided herein must incorporate
    the terms of the license provided in this Section 13.1 in a written
    sublicense agreement acceptable to PerSeptive in form and substance, which
    will be made available to PerSeptive upon request.  No other license is
    granted to Sequenom either directly or by implication, estoppel or
    otherwise by PerSeptive under this Section 13. 1.

    13.2  PerSeptive represents that it is the exclusive licensee, with the
    right to sublicense, of U.S. Patent Nos. 5,288,644; 5,453,247; and
    5,643,798, and the nonexclusive licensee, with right to sublicense, subject
    to certain rights of the licensor to recapture exclusive rights, of U.S.
    Patent No. 5,045,694 (collectively, the "DNA Patents").  PerSeptive grants
    a      ***      sublicense to Sequenom, upon the purchase of the Product,
    ***
    ***          in the DNA Patents, thereby providing Sequenom the freedom to
    ***                                      the Product, under the DNA
    Patents, and to sublicense such rights solely to those Customers of
    Sequenom who purchase such Product as part of a Sequenom system.  The price
    of each Product                    ***                           ***

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                       12
<PAGE>

    per product.  Any sublicense extended to its Customers by Sequenom as
    provided herein must incorporate the terms of the license provided in this
    Section 13.2 in a written sublicense agreement acceptable to PerSeptive in
    form and substance, which will be made available to PerSeptive upon
    request.  No other license is granted to Sequenom either directly or by
    implication, estoppel or otherwise by PerSeptive under this Section 13.2.

    13.3  PerSeptive hereby grants to Sequenom a limited license to use and
    modify the Delayed Extraction technology and the DNA Patents only to the
    extent necessary and solely for the purposes of internal use, testing and
    marketing.

14. TRADEMARKS; PROMOTIONAL MATERIALS
    ---------------------------------

    14.1  PerSeptive hereby grants Sequenom a non-transferable,
    nonsublicensable, nonexclusive license to use the Trademarks, without
    modification unless approved by PerSeptive as set forth in Section 14.2,
    solely in connection with Sequenom with Sequenom marketing, and
    distribution of the Products and Sequenom system.  Sequenom may place its
    own trademarks and brand identification on the Products it purchases
    hereunder provided that (i) Sequenom's trademarks and identification are
    displayed in a size no greater than of those of PerSeptive and (ii)
    Sequenom's trademarks and identification are placed on the Products in a
    manner that is not likely to cause confusion with PerSeptive's trademarks
    and brand identification.

    14.2  Within thirty (30) days of the Effective Date, Sequenom will submit
    for approval by PerSeptive, which shall not be unreasonably withheld, a
    design layout showing the use of Sequenom's trademarks and brand
    identification on the Products.  Any subsequent changes to such layout will
    similarly require PerSeptive's approval.

    14.3  All advertisements and other promotional materials and other
    descriptions of systems that include Products published by Sequenom shall
    include a notation that the Products have been manufactured by PerSeptive
    under agreement with Sequenom and an indication of the applicable license
    rights accompanying the sale of Products as set forth in Sections 13.1 and
    13.2.

15. CONFIDENTIALITY
    ---------------

    15.1  During the term of this Agreement, all Confidential Information
    exchanged or developed under this Agreement shall be kept strictly
    confidential by either party and shall not be used by either party nor
    disclosed by either party to any third party for any purpose except those
    of this Agreement and within either party's own organization only to
    employees or consultants who have undertaken a similar obligation for the
    time during and after the term of their employment or consulting contract.
    This obligation shall not extend to any Confidential Information that is
    now or subsequently becomes part of the public domain through no breach of
    this Agreement.  By way of example but not by way of limitation, all
    information relating to PerSeptive's sale of Products (e.g., price,
    quantity, discount, delivery schedule, Product improvements, SOP documents,
    operation

                                       13
<PAGE>

    manuals, schematics, design specifications, manufacturing procedures, etc.)
    and Specifications shall be deemed PerSeptive's Confidential Information.

    15.2  The provisions of Section 15.1 shall survive any termination of this
    Agreement and continue in force for a period of five (5) years following
    the effective date of any such termination.

16. LIMITATION OF LIABILITY; INDEMNIFICATION
    ----------------------------------------

    16.1  Except solely with respect to damages for personal injury caused by
    PerSeptive's negligence or willful misconduct, PerSeptive's liability
    arising out of this Agreement, including without limitation on account of
    any breaches or default, or from or on account of any Products sold
    pursuant to this Agreement, or the use thereof, arising from whatever
    cause, whether tort, breach of contract, warranty, or otherwise, excepting
    solely fraud, is limited to one million dollars ($1,000,000) in the
    aggregate.  This Section does not limit liability for bodily injury of a
    person.

    16.2  NOTWITHSTANDING ANYTHING CONTAINED IN THIS AGREEMENT TO THE CONTRARY,
    IN NO EVENT SHALL PERSEPTIVE BE LIABLE, WHETHER IN CONTRACT, TORT,
    WARRANTY, OR UNDER ANY STATUTE (INCLUDING WITHOUT LIMITATION ANY TRADE
    PRACTICE, UNFAIR COMPETITION OR OTHER STATUTE OF SIMILAR IMPORT) OR ON ANY
    OTHER BASIS, FOR INDIRECT, PUNITIVE, MULTIPLE, INCIDENTIAL, CONSEQUENTIAL
    OR SPECIAL DAMAGES SUSTAINED BY SEQUENOM OR ANY OTHER PERSON ARISING OUT OF
    OR IN CONNECTION WITH ANY ASPECT OF THIS AGREEMENT OR ITS PERFORMANCE OR
    ANY FAILURE IN PERFORMANCE OR BREACH, OR THE USE OR PERFORMANCE, OR
    CONSEQUENCES OF USE OR PERFORMANCE, OF ANY PRODUCTS MANUFACTURED OR
    FURNISHED BY PERSEPTIVE WHETHER OR NOT FORESEEABLE AND WHETHER OR NOT
    PERSEPTIVE IS ADVISED OF THE POSSIBILITY OF SUCH DAMAGE, INCLUDING, WITHOUT
    LIMITATION, DAMAGES ARISING FROM OR RELATED TO LOSS OF USE, LOSS OF DATA,
    FAILURE OR INTERRUPTION IN THE OPERATION OF ANY EQUIPMENT OR SOFTWARE,
    DELAY IN REPAIR OR REPLACEMENT, OR FOR LOSS OF REVENUE OR PROFITS, LOSS OF
    GOODWILL, OR LOSS OF BUSINESS UNLESS EXPLICITLY PROVIDED FOR HEREIN.

    16.3  Sequenom agree to defend PerSeptive and its Affiliates at its cost
    and expense, and will indemnify and hold PerSeptive, its Affiliates and
    their respective directors, officers, employees and agents (the "PerSeptive
    Indemnified Parties") harmless from and against any liabilities, losses,
    costs, damages, fees or expenses (including reasonable attorney's fees)
    arising out of any claim relating to (i) any breach by Sequenom of any of
    its representations, warranties or obligations pursuant to this Agreement
    or (ii) personal injury or property damage from the use, sale or other
    disposition of any Product or service offered by Sequenom and/or its
    respective licensees or collaborators or (iii)

                                       14
<PAGE>

    the negligence or willful misconduct of Sequenom, except in all cases to the
    extent caused by the negligence or Willful misconduct of PerSeptive.

    16.4  PerSeptive agrees to defend Sequenom and its Affiliates at its cost
    and expense, and will indemnify and hold Sequenom, its Affiliates and their
    respective directors, officers, employees and agents (the "Sequenom
    Indemnified Parties") harmless from and against any liabilities, losses,
    costs, damages, fees or expenses (including reasonable attorney's fees)
    arising out of any claim relating to (i) any breach by PerSeptive of any of
    its representations, warranties or obligations pursuant to this Agreement
    or (ii) personal injury or property damage from the negligent development
    and manufacture of any Product or service offered by PerSeptive or its
    licensees or collaborators or (iii) the negligence or willful misconduct of
    PerSeptive, except in all cases to the extent caused by the negligence or
    willful misconduct of Sequenom.

    16.5  Whenever any claim shall arise for indemnification hereunder, the
    party seeking indemnification (the "Indemnified Party") shall promptly
    notify the party from whom indemnification is sought (the "Indemnifying
    Party").  Such notice shall specify the nature of the claim and, when
    known, the facts constituting the basis for, as well as the amount or an
    estimate of the amount of the liability arising from, such claim.  Failure
    to promptly notify shall not relieve a Party from its indemnity obligations
    hereunder except to the extent of prejudice caused by such failure.  The
    Indemnified Party shall not settle or compromise any claim by a third party
    for which it is entitled to indemnification hereunder without the prior
    written consent of the Indemnifying Party, which shall not be unreasonably
    withheld, unless suit shall have been instituted against it and the
    Indemnifying Party shall not have taken control of such suit after
    notification thereof as provided in Section 16.6.

    16.6  In connection with any claim giving rise to indemnity under Section
    16 of this Agreement, the Indemnifying Party at its sole cost and expense
    may, upon written notice to the Indemnified Party, assume the defense of
    any such claim or legal proceeding if it acknowledges to the Indemnified
    Party in writing its obligations to indemnify the Indemnified Party with
    respect to all elements of such claim.  The Indemnified Party shall be
    entitled to participate in (but not control) the defense of any such
    action, with its counsel and at its own expense.  If the Indemnifying Party
    does not assume the defense of any such claim or litigation resulting
    therefrom within thirty (30) days after the date notice of such claim is
    given, the Indemnified Party may defend against such claim or litigation,
    without prejudice to pursue its rights of indemnity.  In such event, the
    Indemnified Party may defend in a manner as it may deem appropriate,
    including, but not limited to, settling such claim or litigation, but only
    after giving written notice of the same to the Indemnifying Party, on such
    terms as the Indemnified Party may deem appropriate, and the Indemnifying
    Party shall be entitled to participate in (but not control) the defense of
    such action, with its counsel and at its own expense.  The Parties shall
    cooperate with each other in the defense of any such third party claim
    pursuant to this Section 16.

                                       15
<PAGE>

17. TERM AND TERMINATION
    --------------------

    17.1  The term of this Agreement shall be for the period beginning on the
    Effective Date and ending three (3) years thereafter.

    17.2  This Agreement shall terminate upon written notice by one Party to
    the other in the event the other Party shall become insolvent, or shall ask
    its creditors for a moratorium, or shall file a voluntary bankruptcy
    petition, or shall suffer appointment of a temporary or permanent receiver,
    trustee, or custodian, for all or a substantial part of its assets who
    shall not be discharged within sixty (60) days.

    17.3  Either Party may terminate this Agreement for default by the other
    Party to perform any of its obligations under this Agreement by notifying
    the other Party in writing of such default and allowing the other party
    thirty (30) days within which to cure such default, unless the default is
    the failure to pay money, in which case the defaulting party shall have
    only five days to cure such default after receiving written notice of
    nonpayment.  If such default is not cured within thirty (30) days from
    receipt of such notice of default (or five (5) days in the case of non-
    payment of money owed), the non-defaulting party may terminate this
    Agreement by written notice to the defaulting party.

    17.4  Except to the extent expressly provided to the contrary, the
    following provisions shall survive the termination of this Agreement: this
    Section 17.4, Section 15, Section 16, Section 18, and Section 19.  Any
    rights of Seller to payments accrued through termination as well as
    obligation of the parties under firm orders for purchase and delivery of
    Products at the time of such termination shall remain in effect, except
    that in the case of termination under Section 17.3, the terminating party
    may elect whether obligations under firm orders will remain in effect and
    except that PerSeptive will have no obligation to manufacture and deliver
    Products that have Delivery Dates more than six (6) months after the date
    of termination.

18. NOTICES
    -------

    18.1  All notices and requests required or authorized hereunder shall be
    given in writing either by personal delivery; by registered or certified
    mail, return receipt requested; or by fax or telex.  Such notice shall be
    deemed to have been given upon, such date that it is so personally
    delivered; the date three (3) days after it is deposited in the mail; or
    the date the same is received by the receiving party's fax or telex
    machine, irrespective of the date appearing therein.

         If to PerSeptive:                   If to Sequenom:
         PerSeptive Biosystems, Inc.         Sequenom, Inc.
         500 Old Connecticut Path            11555 Sorrento Valley Road, Suite C
         Framingham, MA 01701                San Diego, CA 92121-1331

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                       16
<PAGE>

         Attention: General Counsel          Attention: Business Development
         Tel: (508) 383-7700                 Tel: (619) 350-0345
         Fax: (508) 383-7468                 Fax: (619) 350-0344

19. GENERAL
    -------

    19.1  Force Majeure

    Except with respect to the payment of money, neither party shall be liable
    for any failure or delay in its performance under this Agreement due to
    causes, including, but not limited to, acts of God, acts of civil or
    military authority, fires, epidemics, floods, earthquakes, riots, wars,
    sabotage, labor shortages or disputes, and governmental actions, which are
    beyond its reasonable control; provided that the delayed party: (i) gives
    the other party written notice of such cause and (ii) uses its reasonable
    efforts to correct such failure or delay in its performance.  The delayed
    party's time for performance or cure under this Paragraph 19.1 shall be
    extended for a period equal to the duration of the cause.

    19.2  Relationship of Parties

    The parties to this Agreement are independent contractors.  Neither party
    nor their respective employees, consultants, contractors or agents are
    agents, employees or joint ventures of the other, nor do they have any
    authority to bind the other by contract or otherwise to any obligation.
    Neither party will not represent to the contrary, either expressly,
    implicitly, by appearance or otherwise.

    19.3  Assignment

    Neither PerSeptive, on one hand, nor Sequenom, on the other hand, may
    assign this Agreement in whole or in part without the consent of the other,
    except if such assignment occurs in connection with the sale or transfer of
    all or substantially all of the business and assets of PerSeptive, on the
    one hand, or Sequenom, on the other, to which the subject matter of this
    Agreement pertains.  Notwithstanding the foregoing, any Party may assign
    its rights (but not its obligations) pursuant to this Agreement in whole or
    in part to an Affiliate of such Party.

    19.4  Successors in Interest

    Subject to Section 19.3, the rights and liabilities of the parties hereto
    will bind and inure to the benefit of their respective successors,
    executors and administrators, as the case may be.

    19.5  Applicable Law

    This Agreement shall be governed by and construed in accordance with the
    laws of the Commonwealth of Massachusetts, U.S.A, exclusive of its
    conflicts of law rules.  Any litigation or other dispute resolution between
    the parties relating to this Agreement shall

                                       17
<PAGE>

    take place in the District of Massachusetts. The parties consent to the
    personal jurisdiction of and venue in the state and federal courts within
    that District.

    19.6  Severability

    If for any reason a court of competent jurisdiction finds any provision of
    this Agreement, or portion thereof, to be unenforceable, that provision of
    the Agreement shall be enforced to the maximum extent permissible so as to
    effect the intent of the parties, and the remainder of this Agreement shall
    continue in full force and effect.

    19.7  No Waiver

    Failure by either party to enforce any provision of this Agreement shall
    not be deemed a waiver of future enforcement of that or any other
    provision.

    19.8  Counterparts

    This Agreement may be executed in one or more counterparts, each of which
    will be deemed an original, but all of which will constitute but one and
    the same instrument.

    19.9  Complete Agreement

    This Agreement, including all Exhibits, constitutes the entire agreement
    between the parties with respect to the subject matter hereof, and
    supersedes and replaces all prior or contemporaneous understandings or
    agreements, written or oral, regarding such subject matter.  No amendment
    to or modification of this Agreement shall be binding unless in writing and
    signed by a duly authorized representative of both parties.

    19.10  Third Party Beneficiaries

    No third party beneficiary rights are conferred or are intended to be
    conferred by this Agreement.

    19.11  Headings

    Headings in this Agreement are for convenience only, and shall not be used
    to and shall not effect the meaning or interpretation of this Agreement.

    19.12  Full Disclosure

    Any representations made by the Parties in this Agreement or any Exhibit
    hereto do not contain any untrue statement of a material fact or omit any
    material fact necessary in order to make the statements contained therein
    misleading.

                                       18
<PAGE>

    19.13  Public Announcements

    Any announcements or similar publicity with respect to the execution of
    this Agreement shall be agreed upon among the Parties in advance of such
    announcement.  All Parties understand that this Agreement is likely to be
    of significant interest to investors, analysts and others, and that any of
    the Parties therefore may make such public announcements with respect
    thereto.  The Parties agree that any such announcement will not contain
    confidential business or technical information and, if disclosure of
    confidential business or technical information is required by law or
    regulation, will make reasonable efforts to minimize such disclosure and
    obtain confidential treatment for any such information which is disclosed
    to a governmental agency or group.  Each Party agrees to provide to the
    other Parties a copy of any public announcement as soon as reasonably
    practicable under the circumstances prior to its scheduled release.  Except
    under extraordinary circumstances, each Party shall provide the other with
    an advance copy of any press release at least five (5) business days prior
    to the scheduled disclosure.  Each Party shall have the right to
    expeditiously review and recommend changes to any announcement regarding
    this Agreement or the subject matter of this Agreement.  Except as
    otherwise required by law, the Party whose press release has been reviewed
    shall remove any information the reviewing Party reasonably deems to be
    inappropriate for disclosure.

IN WITNESS WHEREOF, the parties have executed this Agreement as of the date
first indicated above.

PerSeptive Biosystems, Inc.        Sequenom, Inc.


By: /s/ Joseph E. Malandrakis        By: /s/ Hubert Koster
    -------------------------            -------------------------
    Name: Joseph E. Malandrakis          Name: Hubert Koster
    Title: VP/ General Manger            Title: President & CEO


Legal:  A.T. Karnalirs

                                       19
<PAGE>

                                  EXHIBIT 2.1

                      Product Price and Discount Schedule

<TABLE>
<CAPTION>
Part No.                            Description                                  ***          ***          ***
- ----------------------------------------------------------------------------------------------------------------------
<S>               <C>                                                            <C>          <C>          <C>
V888520           Voyager-DE Biospectrometry Workstation with Data                            ***
                  System*
                               License Fee for DNA Patents
- ----------------------------------------------------------------------------------------------------------------------
V700454           500 MHz Acquisition System*                                                 ***
- ----------------------------------------------------------------------------------------------------------------------
V999999           Negative Ion Capability                                                     ***
- ----------------------------------------------------------------------------------------------------------------------
V700388           Sample Video Monitor System                                                 ***
                  (US, Canada and Japan Only)
- ----------------------------------------------------------------------------------------------------------------------
V700718           Sample Video Monitor System                                                 ***
                  (EU and rest of world)
- ----------------------------------------------------------------------------------------------------------------------
V700715           High Current Detector for Voyager-DE
                  (factory installed)
- ----------------------------------------------------------------------------------------------------------------------
V888630           Voyager-DE PRO Biospectrometry Workstation with Data                        ***
                  System (US Canada and Japan only)*
                              License Fee for DNA Patents
- ----------------------------------------------------------------------------------------------------------------------
V899630           Voyager-DE PRO Biospectrometry Workstation with Data                        ***
                  System (EU and rest of world)*
                              License Fee for DNA Patents
- ----------------------------------------------------------------------------------------------------------------------
V725113           2 GHz Acquisition System*                                                   ***
- ----------------------------------------------------------------------------------------------------------------------
V700400           CID Module                                                                  ***
- ----------------------------------------------------------------------------------------------------------------------
V700716           High Current Detector for Voyager-DE PRO                                    ***
                  (factory installed)
- ----------------------------------------------------------------------------------------------------------------------
N/A               Installation for Voyager-DE Workstation**                                   ***
- ----------------------------------------------------------------------------------------------------------------------
N/A               Installation for Voyager-DE PRO Workstation**                               ***
- ----------------------------------------------------------------------------------------------------------------------
N/A               Field Labor Support Rate                                                    ***
- ----------------------------------------------------------------------------------------------------------------------
N/A               Extended Support for Voyager-DE Workstation                                 ***
                              a)  BioMaintenance Plan
                              b)  BioAssurance Plan
                              c)  BioAssurance Plus Plan
- ----------------------------------------------------------------------------------------------------------------------
N/A               Extended Support for Voyager-DE PRO Workstation                             ***          ***
                              a)  Maintenance Plan
                              b)  BioAssurance Plan
                              c)  BioAssurance Plus Plan
- ----------------------------------------------------------------------------------------------------------------------
</TABLE>

  * Minimum Required Configuration for System Product
 ** Includes Travel Expenses

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                       20

<PAGE>

<TABLE>
<CAPTION>
<S>                                                          <C>
                                                                                                                       EXHIBIT 10.34
- -------------------------------
ARS CFDA NO. 10.001                                                                                                           Page 1
- ------------------------------------------------------------------------------------------------------------------------------------
          United States Department of Agriculture            TYPE OF RESEARCH AGREEMENT
                   EXTRAMURAL AGREEMENT                                   Specific Cooperative Agreement
- ------------------------------------------------------------------------------------------------------------------------------------
TITLE OF PROJECT                                             AGREEMENT NO.                TYPE OF ACTION
                                                                    58-5438-9-120         New
                                                             -----------------------------------------------------------------------
Development and Use of a High Speed Genotypign               PERIOD OF AGREEMENT
      System for Livestock                                   15-Jun-99               thru                01-Feb-01
- ------------------------------------------------------------------------------------------------------------------------------------
                                                             FEDERAL OBLIGATION           CHANGE IN FEDERAL OBLIGATION
                                                                         ***              []+  []-   N/A
- ------------------------------------------------------------------------------------------------------------------------------------
AGENCY (Name and Address)                                    CRIS NO.                     AUTHORITY
USDA, Agricultural Research Service                          5438-31000-048-01s                  7USC 3318(b)
                                                             -----------------------------------------------------------------------
Northern Plains Area                                           OBLIGATION DISTRIBUTION
Grants and Agreements Office                                       Accounting Code                  Amount
1201 Oakridge Drive, Suite 150
Fort Collins, CO  80525-5562                                         9015438020                       ***
- ------------------------------------------------------------------------------------------------------------------------------------
ARS AUTHORIZED DEPARTMENTAL OFFICER'S DESIGNATED             COOPERATOR (Name and Address)
REPRESENTATIVE (Name and Address)

Gary L. Bennett                                              Sequenom, Inc.
USDA, Agricultural Research Service                          11555 Sorrento Valley Road
U.S. Meat Animal Research Center                             San Diego, CA  92121-1331
Box 166
Clay Center, NE 68933
- ------------------------------------------------------------------------------------------------------------------------------------
ARS FINANCE OFFICE (Complete Mailing Address)                COOPERATOR'S DESIGNATED REPRESENTATIVE  (Name and Address)

USDA, Agricultural Research Service                          Daniel P. Little
Northern Plains Area                                         Sequenom, Inc.
Budget and Fiscal Office                                     11555 Sorrento Valley Road
1201 Oakridge Drive, Suite 150                               San Diego, CA 92121-1331
Fort Collins, CO 80525-5562
- ------------------------------------------------------------------------------------------------------------------------------------
                                               APPLICABLE PROVISIONS AND REGULATIONS
This Agreement includes the following:                             Payment:
     [X]  Statement of Work; of                                             [_]  HHS/Payment Management System
     [_]  Project Summary; or                                               [X]  Invoice/Treasury Check (Electronic Funds Transfer)
     [_]  Proposal; and                                                     [_]  Advance Payment Authorized
     [X]  Budget (Form ARS-454/455)                                         [_]  Pre-Award Costs Authorized (See Below)
     [X]  USDA Civil Rights Poster (Form AD-475A); and
Provisions:                                                  Reporting Requirements:
     [X]  General (Form ARS-452)                             Submit:        [X]  Performance Reports   [X]  Financial Reports
     [_]  Special (Form ARS-453)                                                  [_]  Quarterly             [_]  Quarterly
Regulations:                                                                      [_]  Semi-annual           [_]  Semi-annual
     [_] 7 CFR 3015.205 (by reference)                                            [X]  Annual                [X]  Annual
     [_] 7 CFR 3016 (by reference)                                                [X]  Final                 [X]  Final
     [_] 7 CFR 3019 (by reference)                                          [_]  Annual Report of Inventions and Subcontracts
     [X] 7 CFR 3015.175(b), Copyrights (by reference)        To:            [X]  ADODR
     [X] 37 CFR Part 401.14, Patents and Inventions                         [_]  Recipient Organization
         (by reference)
Appendices and Schedules:
     [_] Appendix A - Application for Funding (ARS-403)
     [_] Appendix B - Current and Pending Federal Financial Assistance Support (ARS-408)
     [_] Appendix C - Research Assurance Statement (ARS-411)
     [_] Appendix D - Civil Rights Assurance Certification (ARS-405)
     [_] Appendix E - Civil Rights Questionnaire (ARS-406)
     [X] Appendix F - Certification Regarding Debarment, Suspension and other
                 Responsibility Matters - Primary Covered Transactions (AD-1047)
     [_] Appendix G - Certification Regarding Debarment, Suspension and other Responsibility Matters - Lower
                 Tier Covered Transactions (AD-1048)
     [X] Appendix H - Certification Regarding Drug-Free Workplace Requirements - Non-individuals (AD-1049)
     [_] Appendix I - Certification Regarding Drug-Free Workplace Requirements - Individuals (AD-1050)
     [X] Appendix J - Certification/Disclosure Requirements Related to Lobbying (SF-LLL)
     [_] Appendix K - Intellectual Property Rights (Applicable to International Agreements only)
     [X] Appendix L - Report of Inventions and Subcontracts

Other (Specify):
     [X] ADODR Instructions
     [X] Organization Certifications (Page 2)

- ------------------------------------------------------------------------------------------------------------------------------------
                                          FOR THE UNITED STATES DEPARTMENT OF AGRICULTURE
- ------------------------------------------------------------------------------------------------------------------------------------
AUTHORIZED DEPARTMENTAL OFFICER             TYPED NAME                                    DATE
    /s/ James E. Quaratino                               James E. Quaratino                           5-14-99
- ------------------------------------------------------------------------------------------------------------------------------------
                                                  FOR THE PERFORMING ORGANIZATION
                                (Signature of persons authorized to incur contractual obligations)
- ------------------------------------------------------------------------------------------------------------------------------------
SIGNATURE                                   TYPED NAME AND TITLE                          DATE
    /s/ Hubert Koster                       Hubert Koster, President/CEO                            May 13, 1999
- ------------------------------------------------------------------------------------------------------------------------------------
SIGNATURE                                   TYPED NAME AND TITLE                          DATE
    /s/ Toni Schuh                          Toni Schuh, Exec. VP, Business                          May 13, 1999
                                            Development
- ------------------------------------------------------------------------------------------------------------------------------------
</TABLE>

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

AGREEMENT NO.: 58-5438-9-120                                         Page 3 of 5
Sequenom, Inc.
San Diego, CA

                           (Check appropriate boxes)

[_]  THE PERFORMING ORGANIZATION CERTIFIES THAT IT IS:
                         OR
[_]  THE SPONSORING ORGANIZATION CERTIFIES THAT IT IS:

Type of Performing/Sponsoring Organization: (Check one only)

[_]  USDA/RE&E Laboratory

[_]  Other Federal Research Agency

[_]  State Agricultural Experiment Station (SAES)

[_]  Land-Grant University of 1862

[_]  Land-Grant University of 1890 or Tuskegee University

[_]  Private University or College

[_]  Public University or College (Non Land-Grant)

[_]  Private Profit-making

[_]  Private Non-profit

[_]  State or Local Government

[_]  Veterinary School or College

[_]  Cooperative Extension Service

[_]  Small Business

[_]  Minority Owned Business

[_]  Female Owned Business

[_]  Individual

[_]  Other (specify)

Please provide the organization's/individual's:

Tax Identification Number (TIN)                   77-0365889
                               -------------------------------------------------
          OR

Employer Identification Number (EIN) ___________________________________________

          OR

Social Security Number (SSN) ___________________________________________________

Form ARS-451, page 2                     DEC. 98                        USDA-ARS
<PAGE>

- --------------------------------------------------------------------------------
                                                                    Page 4 of 5
Agreement No. 58-5438-9-120
Sequenom - San Diego, CA
- --------------------------------------------------------------------------------

OBJECTIVE:

The objective of this cooperative research project is to develop and implement a
high speed mass spectrophotometer based genotyping system for livestock. This
requires a system to utilize primers for single nucleotide polymorphism (SNP) in
livestock.

APPROACH:

A mass spectrophotometer based high speed genotyping system is required for use
of SNP's to genotype livestock populations. To efficiently use expressed
sequence tags (EST) sequence data in livestock and link this information with
the human genome database, we must be able to genotype SNP's in livestock
populations. Preliminary studies with the Sequenom DNA MassArray analytical
system have demonstrated this system can be used effectively to genotype SNP's
in livestock. This system will be implemented and upgraded to develop markers
for SNP's and map these markers on the ARS linkage maps.

STATEMENT OF MUTUAL INTEREST:

Both parties are actively engaged in independent research projects to identify
and implement efficient SNP genotyping systems. This project combines Sequenom's
expertise and technology relating to their DNA MassArray Basic System Plus and
ARS's expertise and technology relating to SNP marker development to develop and
implement a high speed SNP genotyping system. The parties agree that meeting the
objectives of this project will strengthen and enhance ongoing research within
the scope of this agreement.

THE COOPERATOR AGREES TO:

1.   Work closely with ARS in planning and providing engineering and systems
support for conducting the research outlined below.

2.   Conduct at ARS facilities and elsewhere as appropriate, engineering and
systems support research to upgrade the DNA MassArray Analytical System for use
in developing markers for SNP's..... activities include:

a.   Provide for the use during this project of a DNA MassArray Basic System
Plus incorporating the following components: a High-speed Bruker/SEQUENOM Array
Mass Spectrometer; a Spectrojet Nanoliter Dispenser; a SEQUENOM BioMASS
lnformatics Workstation and use of appropriate software; Beckman Multimek
Instrument with SEQUENOM Magnetic Lifters. Provide hardware and software
upgrades to the system as they become available.

b.   Provide SEQUENOM 96 D SpectroChipTM , reagents, and the magnetic beads
required in sample preparation for 200,000 elements (excluding the reagents
provided for by ARS and

<PAGE>

- --------------------------------------------------------------------------------
                                                                    Page 5 of 5
Agreement No. 58-5438-9-120
Sequenom - San Diego, CA
- --------------------------------------------------------------------------------

outlined below). An element is defined as a sample pad on SEQUENOM's
SpectroChipTM (Patent US 5,605,798).

c.   Assist in developing markers to run on this "system."

d.   Assist in integrating DNA MassArray data with the ARS livestock database.

ARS AGREES TO:

1.   Work closely with the cooperator in planning and conducting the research
outlined above.

2.   Conduct research on the following aspects of the project:

a.   Develop primers to amplify specific regions of DNA (Primers and PCR
reagents will be provided by ARS).

b.   Identify SNP markers within the amplified fragments.

c.   Synthesize probe primers that can be used with the DNA MassArray Basic
System to genotype the SNPs (reagents to be provided by ARS include primers,
neucleotides, enzymes, biotinylated primers).

d.   Utilize SNP genotypic data to place the markers on the linkage map.

MUTUAL AGREEMENTS:

1.   The estimated budget, Form ARS-454, is hereby incorporated into the
agreement. The awarding agency will reimburse the Cooperator for costs related
to salaries, material, supplies in the amount of *** , and will contribute
in-house resources in the amount of *** . As evidence of the Cooperator's
contribution to this project the Cooperator will provide in-house resources in
the amount of *** .

2.   Payments to the Cooperator will be made quarterly via Electronic Funds
Transfer (EFT), upon submission of a properly executed invoice. See ARS-452,
Part 15 (Attached). Reimbursement for the use of the DNA MassArray Basic System
*** will be made after delivery of the system and evidence that ARS can produce
acceptable results; reimbursement of expenses associated with the BioMass Probe
reaction units *** will be based on quantity used; and the monthly maintenance
fee will be reimbursed on a quarterly basis.

3.   The use of the DNA MassArray Basic System Plus and Spectrochip (System)
will be solely used for purposes of livestock SNP analysis. The Cooperator shall
retain title and

     ***
        Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

- --------------------------------------------------------------------------------
                                                                    Page 6 of 5
Agreement No. 58-5438-9-120
Sequenom - San Diego, CA
- --------------------------------------------------------------------------------

ownership of these equipment items. ARS agrees to use this System only in the
ordinary course of testing and will not reproduce or modify the System or any
portion thereof. ARS agrees not to transfer the System or any part of thereof or
use it for the benefit of a third party or attempt to discover underlying
Proprietary Information. ARS agrees to take reasonable measures to maintain in
confidence Proprietary Information regarding the SEQUENOM DNA MassArray Basic
System.

4.   Correspondence and documentation regarding this Agreement should cite
Agreement Number 58-5438-9-120 and copies of such correspondence and
documentation between the Cooperator and the ADODR shall be sent by the
originating party to the ADO at:

                  James E. Quaratino
                  USDA, Agricultural Research Service
                  Northern Plains Area
                  Grants and Agreements Office
                  1201 Oakridge Drive, Suite 150
                  Fort Collins, CO 80525-5562

<PAGE>

                        U.S. DEPARTMENT OF AGRICULTURE
                         AGRICULTURAL RESEARCH SERVICE
                         COOPERATIVE AGREEMENT BUDGET

<TABLE>
<CAPTION>
- ---------------------------------------------------------------------------------------------------------------------
COOPERATOR:
Sequenom, Inc.                                              ARS                  ARS
San Diego, CA                                                TO                IN-HOUSE            COOPERATOR
AGREEMENT NO. 58-5438-9-120                               REIMBURSE             COSTS            CONTRIBUTION(S)
- ---------------------------------------------------------------------------------------------------------------------
<S>                                                       <C>                  <C>               <C>
A.  Salaries and Wages

    1. Pl(s)/PD(s)...............................                                       ***
                                                        -------------------------------------------------------------
    2. Other Professional Personnel..............                                                              ***
                                                        -------------------------------------------------------------
    3. Support Personnel.........................                                       ***                    ***
                                                        -------------------------------------------------------------

       Total Wages and Salaries..................                  ***                  ***                    ***
- ---------------------------------------------------------------------------------------------------------------------
B.  Fringe Benefits (if charged as Direct Costs).                  ***                                         ***
- ---------------------------------------------------------------------------------------------------------------------
C.  Total Salaries, Wages, and Fringe Benefits (A
    plus B)......................................                  ***                  ***                    ***
- ---------------------------------------------------------------------------------------------------------------------
D.  Nonexpendable Equipment (Attach supporting data)               ***
    (List items and dollar amounts for each item)
- ---------------------------------------------------------------------------------------------------------------------
E.  Materials and Supplies.......................                  ***                  ***                    ***
- ---------------------------------------------------------------------------------------------------------------------
F.  Travel

1.  Domestic (including Canada)..................                  ***
                                                        -------------------------------------------------------------
2.  Foreign (List destination and amount
    for each trip)                                                 ***
- ---------------------------------------------------------------------------------------------------------------------
G.  Publication Costs/Page Charges...............                  ***
- ---------------------------------------------------------------------------------------------------------------------
H.  Automated Data Processing (Computer) Costs...                  ***
- ---------------------------------------------------------------------------------------------------------------------
I.  All Other Direct Costs (Attach supporting data) .                                   ***
    .... Livestock

DNA Mass Array System, 400000                                      ***
                           Maintenance fee 36000
    (List items and dollar amounts for each item)
- ---------------------------------------------------------------------------------------------------------------------
J.  Total Direct Costs (C through 1).............                  ***                  ***                    ***
- ---------------------------------------------------------------------------------------------------------------------
K. Indirect Costs (Specify rate and base)........                                                              ***

Rate ______%                  Base ________
- ---------------------------------------------------------------------------------------------------------------------
L. Total Costs (J plus K) .......................                  ***                  ***                    ***
- ---------------------------------------------------------------------------------------------------------------------
</TABLE>
COMMENTS
This agreement provides for use of the DNA MassArray Basic System Plus as
defined in agreement.



NOTES:
1.  A separate budget is required for each funding period.
2.  Federal Statute (7 U.S.C. 3318 (b)(1 )(B) ) requires a contribution of
    resources by all parties toward meeting the objectives of the Cooperative
    Agreement.
3.  ARS is prohibited from reimbursing State Cooperative Institutions for
    indirect costs or tuition remission. Indirect costs will be reimbursed only
    upon receipt of an approved Indirect Cost Rate Schedule.
4.  Unrecovered indirect costs may be used to meet a portion of the resource
    contribution requirement toward the cooperative effort.
5.  Unallowable costs as defined in OMB Circulars, A-21, A-122, or A-87 as
    applicable, cannot be considered a resource contribution.
- -------------------------------------------------------------------------------
ARS-454 (10/98)




      ***
         Portions of this page have been omitted pursuant to a Confidential
Treatment and filed separately with the Commission.

<PAGE>

                    United States Department of Agriculture
                              General Provisions
                     Non-Assistance Cooperative Agreement

________________________________________________________________________________

                               TABLE OF CONTENTS

<TABLE>
<CAPTION>
      Subject                                                          Page
      -------                                                          ----
<S>                                                                    <C>
1.    Definitions......................................................   1
2.    Legal Authority Certification....................................   2
3.    Level of Performance.............................................   2
4.    Funding Availability.............................................   2
5.    Assurances.......................................................   2
6.    Allowable Costs..................................................   3
7.    ADODR Responsibilities...........................................   3
8.    Prior Approvals..................................................   3
9.    Project Continuance..............................................   4
10.   Reporting Requirements...........................................   4
11.   Technical Supervision............................................   5
12.   Rules of the Workplace...........................................   5
13.   Patents and Copyrights...........................................   5
14.   Project Data.....................................................   6
15.   Payments.........................................................   6
16.   Debt Collection..................................................   6
17.   Acknowledgment of Support
      and Disclaimer...................................................   7
18.   Capital Improvement and Travel...................................   7
19.   Advertising......................................................   7
20.   Title to Equipment...............................................   7
21.   Equipment Management Requirements................................   7
22.   Motor Vehicle Accident Liability.................................   7
23.   Liability - Other................................................   7
24.   Termination by Mutual Agreement..................................   8
25.   Suspension or Termination for Cause..............................   8
26.   Questions and Survey Plans.......................................   8
27.   Retention and Access Requirements
      for Records......................................................   8
</TABLE>
___________________________________________________________________________

1.     DEFINITIONS

The following terms shall have the meaning set forth below:

a.     Awarding Agency - The USDA Agency making the award; Agricultural Research
       Service (ARS), Economic Research Service (ERS), or the National
       Agricultural Statistics Service (NASS), and for subawards, the
       Cooperator.

b.     Authorized Departmental Officer (ADO) - The Awarding Agency Official
       authorized to enter into, administer, and terminate Non-Assistance
       Cooperative Agreements.

c.     Non-Assistance Cooperative Agreement - An Agreement, which is neither a
       Procurement Contract nor an Assistance-Type Cooperative Agreement, that
       furthers agricultural research, extension, or teaching programs in which
       the objectives of the agreement serve a mutual interest of the parties
       and all parties contribute resources to the accomplishment of those
       objectives, hereinafter referred to as the Agreement.

d.     Cooperator - The signature party or parties to this Agreement receiving
       Federal funds.

e.     International Cooperator - The signature party or parties to this
       Agreement receiving Federal funds incorporated and or headquartered
       outside the continental United States and its territories.

f.     Authorized Departmental Officer's Designated Representative (ADODR) - The
       Awarding Agency's technical representative, acting within the scope of
       delegated authority, who is responsible for participating with the
       Cooperator in the accomplishment of this Agreement's objectives and
       monitoring and evaluating the Cooperator's performance.

g.     Principal Investigator (PI) - The Cooperator's technical representative
       who is responsible for conducting the effort of the Cooperator in the
       accomplishment of this Agreement's objectives.

h.     Treasury Check - A method of receiving payment by paper check from the
       U.S. Treasury.

i.     HHS/PMS Health and Human Services/Payment Management System - a method of
       receiving payment by electronic draw down.

                                       1
<PAGE>

j.     Electronic Funds Transfer (EFT) Electronic transfer of funds to the
       Cooperator's bank account.

k.     OMB - Office of Management and Budget

l.     CFR - Code of Federal Regulations

M.     USC - United States Code

n.     FAR - Federal Acquisition Regulations

2.     LEGAL AUTHORITY CERTIFICATION

The Cooperator hereby certifies that it possesses legal authority to enter into
this Agreement.

3.     LEVEL OF PERFORMANCE

The Cooperator will use its best efforts to provide performance under this
Agreement within the Federal obligation amount shown on page 1 of this Agreement
and will notify the ADODR when it is anticipated that performance under this
Agreement will exceed this amount. The Cooperator is not obligated to continue
performance under this Agreement, or otherwise incur costs in excess of the
Federal obligation amount, unless authorized by the ADO. Costs incurred in
excess of the Federal obligation shall not be reimbursed without approval and
written ratification by the Director, Extramural Agreements Division, ARS.
Unallowable costs will not be approved in any case.

4.     FUNDING AVAILABILITY

The Awarding Agency's participation shall be subject to passage, by the Congress
of the United States, of an appropriation of funds for the fiscal year from
which expenditures may be legally made.

5.     ASSURANCES

(Not applicable to Agreements awarded to International Cooperators)

The Cooperator hereby gives assurance that it will comply with the following:

a      International Air Transportation Fair Competitive Practices Act of 1975,
       Section 5 (49 USC 1517). Costs for foreign travel and related
       transportation of property are allowable only to the extent that United
       States flag air carriers are used.;

b.     Nondiscrimination Requirements:

       Rehabilitation Act of 1973 - Section 504; Sex Discrimination - Title IX
       of the Education Amendments of 1972, as amended; Age Discrimination Act
       of 1975; Civil Rights Act of 1964 - Title VI (42 U.S.C. 2000d).

       The Cooperator also agrees to display form AD-475A, USDA Civil Rights
       Poster entitled "And Justice for All," in common areas of its facility
       where the federally assisted research is being conducted during the
       performance period of the project. (Not applicable to awards with
       International Cooperators).

C.     Protection of Human Subjects Requirements: The Cooperator will comply
       with the following provisions regarding the rights and welfare of human
       subjects:

       (1)    The Cooperator is responsible for safeguarding the rights and
              welfare of any human subjects involved in research, development,
              and related activities supported by this Agreement. The Cooperator
              may conduct research involving human subjects only as prescribed
              An the statement of work and as approved by the Cooperator's
              cognizant Institutional Review Board. Prior to conducting such
              research, the Cooperator shall obtain and document a legally
              sufficient informed consent from each human subject involved. No
              such informed consent shall include any exculpatory language
              through which the subject is made to waiver, or to appear to
              waiver, any of his or her legal rights, including any release of
              the Cooperator or its agents from liability for negligence.

       (2)    The Cooperator agrees to comply with U.S. Department of Health and
              Human Services' regulations regarding human subjects, appearing in
              45 CFR Part 46 (as amended).

       (3)    It will comply with USDA policy which is to assure that the risks
              do not outweigh either potential benefits to the subjects or the
              expected value of the knowledge sought.

                                       2
<PAGE>

       (4)    Selection of subject or groups of subjects shall be made without
              regard to sex, race, color, religion, or national origin unless
              these characteristics are factors to be studied.

d.     Animal Welfare Act Requirements: The Cooperator agrees that it will
       comply with the Animal Welfare Act, as amended, 7 U.S.C. 2131, et seq.,
       and the regulations promulgated thereunder by the Secretary of
       Agriculture (9 CFR, Subchapter A) pertaining to the care, handling, and
       treatment of warm-blooded animals held or used for research, teaching, or
       other activities supported by Federal funds. The Cooperator may request
       registration of facilities and a current listing of licensed dealers from
       the Regional Office of the Animal and Plant Health Inspection Service
       (APHIS), USDA, for the Region in which their facility is located. The
       location of the appropriate APHIS Regional Office, as well as information
       concerning this requirement, may be obtained by contacting the Senior
       Staff Officer, Animal Care Staff, USDA/APHIS, 4700 River Road, Riverdale,
       Maryland 20737.

e.     Recombinant DNA Research Requirements: The Cooperator will assume primary
       responsible for implementing proper conduct on recombinant DNA research
       and it will comply with the National Institute of Health Guidelines for
       Recombinant DNA Research, as revised.

       If the Cooperator wishes to send or receive registered recombinant DNA
       material which is subject to quarantine laws, permits to transfer this
       material into the U.S. or across state lines may be obtained by
       contacting USDA/APHIS/PPQ, Scientific Services-Biotechnology Permits,
       4700 River Road, Unit 133, Riverdale, Maryland 20737. In the event that
       the Cooperator has not established the necessary biosafety committee, a
       request for guidance or assistance may be made to the USDA Recombinant
       DNA Research Officer.

f.     That it will assist the Awarding Agency in complying with the: National
       Historic Preservation Act of 1966 Section 106, as amended, (16 U.S.C.
       470, Executive Order 11593); Archaeological and Historic Preservation Act
       of 1966 (16 U.S.C. 469a-1 et. seg.);
                                 --  ---

g.     The Cooperator will comply with Federal regulations regarding equal
       opportunity, nonsegregated facilities and affirmative action (41 CFR,
       Chapter 60); and

h.     USDA regulations at 7 CFR 3017 subparts A through E and 7 CFR 3018
       regarding debarment and suspension, drug-free workplace, and anti-
       lobbying act requirements.

i.     The Single Audit Act (Public Law 98-502), as implemented by OMB Circular
       A-1 33.

6.     ALLOWABLE COSTS

a.     Payment up to the amount specified in this Agreement shall be made only
       for allowable, allocable, reasonable, and necessary costs in accordance
       with the following cost principles in effect on the date of the award:

       (1)    For institutions of higher education - OMB Circular No. A-21;

       (2)    For State, local or federally-recognized Indian tribal
              governments - OMB Circular No. A-87;

       (3)    For nonprofit organizations - OMB Circular No. A-122;

       (4)    For hospitals - Appendix C of 45 CFR Part 74; or

       (5)    For commercial organizations and those non-profit organizations
              listed in attachment C to Circular A- 122 - FAR at 48 CFR part 31.

7.     ADODR RESPONSIBILITIES

The ADO has delegated ADODR responsibilities to the individual named on page 1
of this Agreement, subject to the limitations as provided for in the ADODR
Designation and Instructions, (attached and made apart hereto).

8.     PRIOR APPROVALS

Written approval of the ADO is required for the following:

a.     To change the PI or to continue the research, education, or information
       work, without the

                                       3
<PAGE>

       participation of the PI, for a period in excess of three continuous
       months.

b.     A substantial reduction of the effort devoted to the work by the PI.

c.     Changes to the objectives of this Agreement, or the phenomenon or
       phenomena under study.

d.     Federal funding increases.

e.     Period of performance extension.

f.     Transfer of amounts within budgeted cost categories.

g.     Reimbursement of pre-award costs.

h.     Purchase of equipment.

i.     Operation of government owned vehicles by Cooperator employees.

j.     The subaward, transfer or contracting out of any work under this
       Agreement. This provision does not apply to the purchase of articles,
       supplies, equipment, and services which are both necessary for and merely
       incidental to the work required under the Agreement.

Generally, no requests for changes to the scope of this Cooperative Agreement
will be approved.

Unilateral amendments to this agreement may be issued by the ADO for changes
which are purely administrative in nature.

9.     PROJECT CONTINUANCE

Prior to completion of the work effort, the parties will review the results and
determine the benefits of continuing the project. In the event the project is
continued, this Agreement will be amended to provide for the additional work
efforts, obligations of the parties, and performance period.

10.    REPORTING REQUIREMENTS

The Cooperator is responsible for monitoring and reporting performance to the
ADO through the ADODR, as follows; (See Form ARS-451, Page 1 of this Agreement,
for the applicable reporting frequency).

Pursuant to the Metric Conversion Act of 1975 Public Law 94-168), whenever
feasible, the Cooperator shall use the metric system in expressing units of
measurement in interim and final performance reports.

All reports must be written in the English language.

a.     Interim Performance Reports.
       Reports are to include:

       (1)    A summary of progress, including a comparison of actual
              accomplishments with goal(s) established for the time period being
              covered and the reasons for slippage if the objectives are not
              met;

       (2)    An outline of any problems encountered or the occurrence of
              unusual or favorable developments during the period; and

       (3)    A brief summary of work to be accomplished during the ensuring
              reporting period.

b.     Final Performance Report.

       Unless otherwise specified in this Agreement, the final performance
       report shall be due 90 calendar days following the expiration,
       completion, or termination date of this Agreement. This report is to
       include appropriate identifying data and the following information:

       (1)    A description of all work results, conclusions, and, if any,
              recommendation;

       (2)    Titles of thesis or dissertations resulting, if any;

       (3)    Names of scientific or other collaborators connected with the
              project, including students (show title or status, e.g., associate
              professor, graduate student);

       (4)    Other deliverables as given in this Agreement;

       (5)    Copies of copyrighted or copyrightable materials including
              computer software;

                                       4
<PAGE>

       (6)    A description of inventions resulting from the work and a
              statement of status concerning any protections sought;

       (7)    A copy of any publications resulting from this Agreement; and,

       (8)    Signature of PI and date.

C.     Significant Developments.

       Events may occur between scheduled performance reporting dates which
       significantly impact the overall effort. Therefore, the Cooperator shall
       promptly notify the ADODR when the following conditions or situations
       surface.

       (1)    Unanticipated delays or adverse conditions which threaten to
              materially impair its ability to meet the prime objective(s) of
              this Agreement. This disclosure is to include a statement of any
              action taken or contemplated and any assistance needed to resolve
              the problem(s); or

       (2)    Favorable developments which are expected to enable it to meet
              established schedules or goals sooner or at less cost than
              anticipated or may produce more beneficial results than originally
              planned.

d.     Financial Reports.

       (1)    Financial Status Reports

       The Cooperator agrees to submit financial status reports to the ADO
       through the ADODR on Standard Form (SF) 269A (short form), Financial
       Status Report, and a final report within 90 days of project completion.

       (2)    Itemized Expense Report
                (Applicable if payment is by HHS/PMS payment method):

              The Cooperator will furnish a detailed addendum attached to the
              (SF) 269A (short form) or (SF) 269 (long form) containing the
              following minimum information or using the Cooperator's format:

              .   Name of Institution
              .   Agreement Number
              .   Reporting Period
              .   Current Quarterly Drawdown
              .   Current Quarterly Expenses
                  Details of Current Quarter's Expenses: Salary and Non-Salary

e.     Where program income is anticipated, Standard Form 269 (long form) shall
       be used. Program income earned during the project period shall be added
       to funds committed to the project by the Federal Awarding Agency and the
       Cooperator and used to further eligible project or program objectives
       unless otherwise specified by the ADO.

f.     Report of Inventions and Subawards.
       The Cooperator agrees to submit an annual report of inventions and
       subawards and a final report within 90 days of project expiration,
       completion, or termination in accordance with Schedule L, (attached and
       made apart hereto). Negative reports required.

11.    TECHNICAL SUPERVISION

The Awarding Agency may technically supervise work of a Cooperator's employees
performed at the Awarding Agency's facilities. The Awarding Agency may not,
however intervene in the employer-employee relationship between a Cooperator and
its employees. In addition, the Awarding Agency may not act so as to hire or
otherwise engage in the personnel management of a Cooperator's employees.

12.    RULES OF THE WORKPLACE

Cooperator employees, while engaged in work at the Awarding Agency's facilities,
will abide by the Awarding Agency's "Rules of the Workplace" such as
(maintenance of a laboratory notebook dissemination of information, equipment
operation standards, hours of work, conduct and other incidental matters stated
in the rules and regulations of the Awarding Agency).

13.    PATENTS AND COPYRIGHTS

(Not applicable to Agreements awarded to International Cooperators. See
Appendix K - International Property Rights - attached and made apart hereto for
Agreements with International Cooperators).

                                       5
<PAGE>

a.     Patents and Inventions.
       The clause found at 37 CFR Part 401.14 is incorporated into this
       Agreement by reference and is applicable to all organizations regardless
       of size.

       Terms are defined as follows:

       (1)    Contractor means the Cooperator Organization as identified on the
              FORM ARS-451, a part hereof.

       (2)    Contract means this Agreement.

b.     Communications.

       (1)    The central point of contact within the U.S. Department of
              Agriculture for communications relating to the administration of
              patents and copyrights is:

              Deputy Asst.  General Counsel for Patents
              Research and Operations Division
              Office of General Counsel
              U.S. Department of Agriculture
              Room 2328, South Building
              Washington, D.C. 20250-1400

       (2)    Disclosure statements are made through the Authorized Departmental
              Officer to:
              Patent Coordinator
              National Patent Program
              USDA, Agricultural Research Service
              1815 N. University Street
              Peoria, IL 61604

       (3)    Utilization statements are made to the Patent Coordinator.

d.     Copyrights.

       The Awarding Agency reserves a royalty-free, nonexclusive, and
       irrevocable license to exercise, and to authorize others to exercise, the
       rights for Federal Government purposes. Subject to this license, the
       owner is free to exercise, preserve, or transfer all its rights. The
       Cooperator shall ensure that no Agreement is entered into for
       transferring the rights which would conflict with the nonexclusive
       license of the Awarding Agency.

       The Cooperator awarding a subaward is allowed to impose subaward terms
       reserving a nonexclusive license for itself, similar to the one reserved
       by the Awarding Agency, with respect to any copyright or rights subject
       to this section that arise under the subaward.

14.    PROJECT DATA

Data which were collected, compiled, and evaluated under this Agreement shall be
shared and mutually interchanged by the Cooperator and the Awarding Agency, with
the final results of this project made available to both parties.

15.    PAYMENTS

Payment will be made by either the HHS/PMS method, the Invoice/Treasury Check
method or EFT. (See Form ARS-451, Page 1 of this Agreement, for the applicable
method).

All payment requests are to be submitted in the English language.

a.     Applicable if payment is by Invoice/Treasury Check method or EFT:

       (i)    Payments by the Awarding Agency to the Cooperator will be made by
              the Invoice/Treasury Check method or EFT for expenditures for each
              previous period as reflected on properly executed invoices or
              vouchers to be prepared by the Cooperator and submitted to the ADO
              through the ADODR. A properly executed invoice shall include, at a
              minimum, the following information:

              .   Awarding Agency agreement number
              .   Organization's name, payment address, and Employee
                  Identification Number Tax Identification Number
              .   Itemized listing of costs to be reimbursed
              .   Specific time period covered by the invoice
              .   Signature of Authorized Organizational Representative

       (ii)   Checks covering payments under this Agreement will be drawn in the
              name of the Cooperator unless a written request

                                       6
<PAGE>

              from the Cooperator accompanies the billing, requesting, for
              purposes of check identification, that such checks also include
              the name of a particular department of the Cooperator's
              organization. If further check identification is needed, the
              Cooperator may:

              .   number the invoice and request that it be shown on the check;

              .   submit the invoice in duplicate and request that one copy of
                  the invoice be returned with the check; or,

              .   request that the Cooperative Agreement number cited on the
                  invoice be shown on the check.

b.     Applicable if payment will be made through the HHS/PMS payment method:

       (i)    HHS/PMS is administered by the Federal Assistance Financing Branch
              (FAFB), Office of the Deputy Assistant Secretary, Finance which
              will forward instructions for obtaining payment. Inquiries
              regarding payments should be directed to:

              Chief, Financial Assistance Financing Branch
              PO Box 6021
              Rockville, Maryland 20852
              (301) 443-1660

c.     Payment by the Awarding Agency to the Cooperator is contingent upon
       receipt of reports in accordance with the terms and conditions of the
       agreement. Payment may be withheld until reports are provided.

d.     Reimbursement to the Cooperator for tuition remission is not allowable
       under this Agreement.

e.     Reimbursement to State Cooperative Institutions for indirect costs is
       unallowable under this Agreement.

f.     Indirect costs shall be paid only upon receipt of an approved negotiated
       indirect cost rate schedule, where authorized by enabling legislation. No
       indirect costs shall be advanced or reimbursed unless supported by an
       approved indirect cost rate schedule.

16.    DEBT COLLECTION

a.     Any monies that are payable or may become payable from the United States
       under this Agreement to any person or legal entity not an agency or
       subdivision or a State or local government may be subject to
       administrative offset for the collection of delinquent debt to the person
       or legal entity owner to the United States under the Federal Claims
       Collection Act of 1966, as amended by the Debt Collection Act of 1982 (31
       USC 3701, 3711, 3716-3719); 4 CFR Part 102 and 7 CFR Part 3.

b.     Information on the person's or legal entity's responsibility for a
       commercial debt or delinquent consumer debt owed the United States will
       be disclosed to consumer or commercial crediting reporting agencies.

17.    ACKNOWLEDGMENT OF SUPPORT AND DISCLAIMER

The following acknowledgment of Awarding Agency support must appear in the
publications of any materials which is based upon or developed under this
Agreement (whether or not copyrighted):

       "This material is based upon work supported by the U.S. Department of
       Agriculture, under Agreement No. (Cooperator should enter the applicable
       agreement number here)."

All such materials, must also contain the following disclaimer unless the
publication is formally cleared by USDA:

       "Any opinions, findings, conclusion, or recommendations expressed in this
       publication are those of the author(s) and do not necessarily reflect the
       view of the U.S. Department of Agriculture."

a.     Public Information working order; and,

       Any public information concerning work carried out under this Agreement
       will describe the contributions of both parties to the work effort. In
       the event of a dispute, a separate publication may be made with effective
       statements of acknowledgment and disclaimer.

                                       7
<PAGE>

b.     Technical Publication.

       Any technical publication developed as a result of this Agreement shall
       be submitted by the developing party to the other for advice and comment.
       In event of dispute, a separate publication may be made, with effective
       statements of acknowledgment and disclaimer.

18.    CAPITAL IMPROVEMENTS AND TRAVEL

No part of the funds made available by the Awarding Agency to the Cooperator
shall be expended for capital improvements or travel of the Awarding Agency's
employees.

19.    ADVERTISING

In advertising, the Cooperator will not refer in any manner to the Federal
Government or agencies thereof in connection with the use of the results of this
research without prior specific written authorization by the ADO. Unless
otherwise provided herein, information obtained as a result of this project will
be made available to the public in printed or other forms by the awarding Agency
at its discretion. The Cooperator will be given due credit for its cooperation
in the project.

20.    TITLE TO EQUIPMENT

As authorized by 7 USC 3318d, title to expendable and nonexpendable equipment,
supplies, and other tangible personal property purchased under this Agreement
shall vest in the Cooperator from date of acquisition unless otherwise stated in
this Agreement.

21.    EQUIPMENT MANAGEMENT REQUIREMENTS

The Cooperator's procedures for managing equipment purchased with Awarding
Agency funds are to meet the following requirements:

a.     Maintain accurate and up-to-date property records;

b.     Property is to be properly maintained in good working order; and,

c.     Property is to be insured.

d.     Either party may furnish equipment and/or facilities, at no cost to the
       other, as may be mutually agreed to between the Cooperator and the ADODR
       for successful completion of this project.

22.    MOTOR VEHICLE ACCIDENT LIABILITY

(Not applicable to Agreements awarded to International Cooperators).

The Awarding Agency will assume responsibility for vehicle repair if the
Awarding Agency determines that the Cooperator's employee was authorized to use
the vehicle, the vehicle was used within the scope of the authorization, and the
Cooperator's employee was not negligent in causing damage. The Cooperator shall
be responsible for damage if the Awarding Agency finds that Cooperator was not
authorized to drive the vehicle, was negligent, or drove the vehicle outside the
scope of authorization.

23.    LIABILITY - OTHER

The Cooperator agrees to indemnify and hold harmless, the Awarding Agency, its
employees, or contractors from and against all liability, claims, and demands on
account of personal injury, property loss, or damage of any kind whatsoever,
which arise out of, or are in any manner connected with, or are claimed to arise
out of or be in any manner connected with, the performance of this Cooperative
Agreement by the Cooperator's employees or agents.

The Cooperator shall provide and maintain the necessary types of insurances, as
may be needed under this Cooperative Agreement, including but not limited to
workers' compensation, employer's liability, and comprehensive general liability
in amounts sufficient to protect the Federal Government's interest in not being
subject to unwarranted damage claims resulting from the Cooperator's use of the
Awarding Agency's facilities.

It is further understood that the Awarding Agency shall not be held responsible
for any breakage, theft, or acts of vandalism to the Cooperator's equipment and
supplies during the period of the Cooperative Agreement.

24.    TERMINATION BY MUTUAL AGREEMENT

This Agreement may be terminated by either of the parties upon 90 calendar days'
notice in writing of one party to the other party.

                                       8
<PAGE>

25.    SUSPENSION OR TERMINATION FOR CAUSE

The Awarding Agency reserves the right to suspend payment if the Cooperator
fails to comply with any terms and conditions of the Agreement, if there is
evidence of the misuse of funds by the Cooperator, if the parties fail to reach
a solution acceptable to both parties regarding any disagreement concerning the
Agreement, or if any other event substantially affects the material terms of
this Agreement.

26.    QUESTIONNAIRES AND SURVEY PLANS

The Cooperator is required to submit to the Awarding Agency copies of
questionnaires and other forms for clearance in accordance with the Paperwork
Reduction Act of 1980 and 5 CFR 1320.

27.    RETENTION AND ACCESS REQUIREMENTS FOR RECORDS

(This requirement is not applicable to International Cooperators).

a.     Financial records, supporting documents, statistical records, and all
       other records pertinent to an award shall be retained for a period of
       three years from the date of submission of the final expenditure report
       or, for awards that are renewed quarterly or annually, from the date of
       the submission of the quarterly or annual financial report, as authorized
       by the Federal Awarding Agency. The only exceptions are:

       (i)    If any litigation, claim, or audit is started before the
              expiration of the 3-year period, the records shall be retained
              until all litigation, claims or audit findings involving the
              records have been resolved and final action taken.

       (ii)   Records for real property and equipment acquired with Federal
              funds shall be retained for 3 years after final disposition.

b.     The Federal Awarding Agency, the Inspector General, Comptroller General
       of the United States, or any of their duly authorized representatives,
       have the right of timely and unrestricted access to any books, documents,
       papers, or other records of Cooperators that are pertinent to the
       Agreement, in order to make audits, examinations, excerpts, transcripts
       and copies of such documents. This right also includes timely and
       reasonable access to a Cooperator's personnel for the purpose of
       interview and discussion related to such documents. The rights of access
       in this paragraph are not limited to the required retention period, but
       shall last as long as records are retained.

c.     This requirement shall be passed through to lower tier subcontractors or
       subawards exceeding $10,000 in value.

                                       9
<PAGE>

                                                                      Appendix F

                        U.S. DEPARTMENT OF AGRICULTURE

- --------------------------------------------------------------------------------
           Certification Regarding Debarment, Suspension, and Other
             Responsibility Matters - Primary Covered Transactions
- --------------------------------------------------------------------------------

This certification is required by the regulations implementing Executive Order
12549, Debarment and Suspension, 7 CFR Part 3017, Section 3017.510,
Participants' responsibilities. The regulations were published as Part IV of the
January 30, 1989, Federal Register (pages 4722-4733). Copies of the regulations
                  ----------------
may be obtained by contacting the Department of Agriculture agency offering the
proposed covered transaction.

        (BEFORE COMPLETING CERTIFICATION, READ INSTRUCTIONS ON REVERSE)

(1)     The prospective primary participant certifies to the best of its
        knowledge and belief, that it and its principals:

        (a)      are not presently debarred, suspended, proposed for debarment,
                 declared ineligible, or voluntarily excluded from covered
                 transactions by any Federal department or agency;

        (b)      have not within a three-year period preceding this proposal
                 been convicted of or had a civil judgement rendered against
                 them for commission of fraud or a criminal offense in
                 connection with obtaining, attempting to obtain, or performing
                 a public (Federal, State or local) transaction or contract
                 under a public transaction; violation of Federal or State
                 antitrust statutes or commission of embezzlement, theft,
                 forgery, bribery, falsification or destruction of records,
                 making false statements, or receiving stolen property;

        (c)      are not presently indicted for or otherwise criminally or
                 civilly charged by a governmental entity (Federal, State or
                 local) with commission of any of the offenses enumerated in
                 paragraph (1)(b) of this certification; and

        (d)      have not within a three-year period preceding this
                 application/proposal had one or more public transactions
                 (Federal, State or local) terminated for cause or default.

(2)     Where the prospective primary participant is unable to certify to any of
        the statements in this certification, such prospective participant shall
        attach an explanation to this proposal.


Sequenom                                      58-5438-9-120
- --------------------------------------------------------------------------------
Organization Name                             PR/Award Number or Project Name


Dr. Toni Schuh, Executive Vice President, Business Development
- --------------------------------------------------------------------------------
Name(s) and Title(s) of Authorized Representative(s)


                                                     May 13, 1999
- --------------------------------------------------------------------------------
Signature (s)                                        Date

                                       1
<PAGE>

                                                                      Appendix F

                        Instructions for Certification
                        ------------------------------
1.  By signing and submitting this form, the prospective primary participant is
providing the certification set on the reverse side in accordance with these
instructions.

2.  The inability of a person to provide the certification required below will
not necessarily result in denial participation in this covered transaction. The
prospective participant shall submit an explanation of why cannot provide the
certification set out on this form. The certification or explanation will be
considered connection with the department or agency's determination whether to
enter into this transaction. However, failure of the prospective primary
participant to furnish a certification or an explanation shall disqualify such
person from participation in this transaction.

3.  The certification in this clause is a material representation of fact upon
which reliance was placed when the department or agency determined to enter into
this transaction. If it is later determined that the prospective primary
participant knowingly rendered an erroneous certification, in addition to other
remedies available to the Federal Government, the department or agency may
terminate this transaction for cause or default.

4.  The prospective primary participant shall provide immediate written notice
to the department or agency to whom this proposal is submitted if at any time
the prospective primary participant learns that its certification was erroneous
when submitted or has become erroneous by reason of changed circumstances.

5.  The terms "covered transaction," "debarred," "suspended," "ineligible,"
"lower tier covered transaction," "participant," "person," "primary covered
transaction," "principal," "proposal," and "voluntarily excluded," as used in
this clause, have the meanings set out in the Definitions and Coverage sections
of the rule implementing Executive Order 12549. You may contact the department
or agency to which this proposal is being submitted for assistance in obtaining
a copy of those regulations.

6.  The prospective primary participant agrees by submitting this form that,
should the proposed covered transaction be entered into, it shall not knowingly
enter into any lower tier covered transaction with a person who is debarred,
suspended, declared ineligible, or voluntarily excluded from participation in
this covered transaction, unless authorized by the department or agency entering
into this transaction.

7.  The prospective primary participant further agrees by submitting this form
that it will include the clause titled "Certification Regarding Debarment,
Suspension, Ineligibility and Voluntary Exclusion - Lower Tier Covered
Transactions," provided by the department or agency entering into this covered
transaction, without modification, in all lower tier covered transactions and in
all solicitations for lower tier covered transactions.

8.  A participant in a covered transaction may rely upon a certification of a
prospective participant in a lower tier covered transaction that it is not
debarred, suspended, ineligible, or voluntarily excluded from the covered
transaction, unless it knows that the certification is erroneous. A participant
may decide the method and frequency by which it determines the eligibility of
its principals. Each participant may, but is not required to, check the
Nonprocurement List.

9.  Nothing contained in the foregoing shall be construed to require
establishment of a system of records in order to render in good faith the
certification required by this clause. The knowledge and information of a
participant is not required to exceed that which is normally possessed by a
prudent person in the ordinary course of business dealings.

10. Except for transactions authorized under paragraph 6 of these instructions,
if a participant in a covered transaction knowingly enters into a lower tier
covered transaction with a person who is suspended, debarred, ineligible, or
voluntarily excluded from participation in this transaction, in addition to
other remedies available to the Federal Government, the department or agency may
terminate this transaction for cause or default.

                                       2
<PAGE>

                                                                      Appendix H

                        U.S. DEPARTMENT OF AGRICULTURE

________________________________________________________________________________

                            Certification Regarding
                   Drug-Free Workplace Requirements (Grants)
              Alternative 1 - for Grantees other than Individuals

________________________________________________________________________________
This certification is required by the regulations implementing Sections
5151-5160 of the Drug-Free Workplace Act of 1988 (Pub. L. 100-690, Title V,
Subtitle D; 41 U.S.C. 701 et. seq.), 7 CFR Part 301 7, Subpart F Section 301
7.600, Purpose. The January 31, 1 989 regulations were amended and published as
Part 11 of the May 25, 1990 Federal Register (pages 21681-21691). Copies of the
                            ----------------
regulations may be obtained by contacting the Department of Agriculture agency
offering the grant.

     (BEFORE COMPLETING CERTIFICATION, READ INSTRUCTIONS, ON PAGE 3)

Alternative 1

A.   The grantee certifies that it will or will continue to provide a drug-free
     Workplace by:

     (a)      Publishing a statement notifying employees that the unlawful
              manufacture, distribution, dispensing, possession, or use of a
              controlled substance is prohibited in the grantee's workplace and
              specifying the actions that will be taken against employees for
              violation of such prohibition;

     (b)      Establishing an ongoing drug-free awareness program to inform
              employees about --

              (1)   The dangers of drug abuse in the workplace;

              (2)   The grantee's policy of maintaining a drug-free workplace;

              (3)   Any available drug counseling, rehabilitation, and
                    employee assistance programs; and

              (4)   The penalties that may be imposed upon employees for drug
                    abuse violations occurring in the workplace;

     (c)      Making it a requirement that each employee to be engaged in the
              performance of the grant be given a copy of the statement required
              by paragraph (a);

     (d)      Notifying the employee in the statement required by paragraph (a)
              that, as a condition of employment under the grant, the employee
              will --

              (1)   Abide by the terms of the statement; and

              (2)   Notify the employer in writing of his or her conviction for
                    a violation of a criminal drug statute occurring in the
                    workplace no later than five calendar days after such
                    conviction;
                                       1
<PAGE>

                                                                      Appendix H

     (e)   Notifying the agency in writing, within ten calendar days after
           receiving notice under subparagraph (d)(2) from an employee or
           otherwise receiving actual notice of such conviction. Employers of
           convicted employees must provide notice, including position title, to
           every grant officer on whose grant activity the convicted employee
           was working, unless the Federal agency has designated a central point
           for the receipt of such notices. Notice shall include the
           identification number(s) of each affected grant;

     (f)   Taking one of the following actions, within 30 calendar days of
           receiving notice under subparagraph (d)(2), with respect to any
           employee who is so convicted --

           (1)  Taking appropriate personnel action against such an employee, up
                to and including termination, consistent with the requirements
                of the Rehabilitation Act of 1973, as amended; or

           (2)  Requiring such employee to participate satisfactorily in a drug
                abuse assistance or rehabilitation program approved for such
                purposes by a Federal, State or local health, law enforcement or
                other appropriate agency;

     (g)   Making a good faith effort to continue to maintain a drug-free
           workplace through implementation of paragraphs (a), (b), (c), (d),
           (e) and (f).

B.   The grantee may insert in the space provided below the site(s) for the
     performance of work done in connection with the specific grant:

Place of Performance (Street address. city. county, State, zip code)

________________________________________________________________________________

________________________________________________________________________________

________________________________________________________________________________

Check ___ it there are workplaces on file that are not identified here.


           SEQUENOM                                     58-5438-9-120
- --------------------------------------------------------------------------------
Organization Name                               Award Number or Project Name


         Dr. Toni Schuh, Executive Vice President, Business Development
- --------------------------------------------------------------------------------
Name and Title of Authorized Representative


________________________________________________________________________________
Signature                                         Date

                                       2
<PAGE>

                                                                      Appendix H
                        Instructions for Certification
                        ------------------------------

1.   By signing and submitting this form, the grantee is providing the
     certification set out on pages 1 and 2

2.   The certification set out on pages 1 and 2 is a material representation of
fact upon which reliance is placed when the agency awards the grant. If it is
later determined that the grantee knowingly rendered a false certification, or
otherwise violates the requirements of the Drug-Free Workplace Act, the agency,
in addition to any other remedies available to the Federal Government, may take
action authorized under the Drug-Free Workplace Act.

3.   Workplaces under grants, for grantees other than individuals, need not be
identified on the certification. If known, they may be identified in the grant
application. If the grantee does not identify the workplaces as the time of
application, or upon award, if there is no application, the grantee must keep
the identity of the workplace(s) on file in its office and make the information
available for Federal inspection. Failure to identify all known workplaces
constitutes a violation of the grantee's drug-free workplace requirements.

4.   Workplace identifications must include the actual address of buildings (or
parts of buildings) or other sites where work under the grant takes place.
Categorical descriptions may be used (e.g., all vehicles of a mass transit
authority or State highway department while in operation, State employees in
each local unemployment office, performers in concert halls or radio studios).

5.   If the workplace identified to the agency changes during the performance of
the grant, the grantee shall inform the agency of the change(s), if it
previously identified the workplaces in question (see paragraph 3).

6.   Definitions of terms in the Nonprocurement Suspension and Debarment common
rule and Drug-Free Workplace common rule apply to this certification. Grantees'
attention is called, in particular, to the following definitions from these
rules:

"Controlled" substance means a controlled substance in Schedules I through V of
the Controlled Substances Act (21 U.S.C. 812) and as further defined by
regulation (21 CFR 1308.11 through 1308.15);

"Conviction" means a finding of guilt (including a plea of nolo contendere) or
imposition of sentence, or both, by any judicial body charged with the
responsibility to determine violations of the Federal or State criminal drug
statutes;

"Criminal drug statute" means a Federal or non-Federal criminal drug statute
involving the manufacture, distribution, dispensing, use or possession of any
controlled substance;

"Employee" means the employee of a grantee directly engaged in the performance
of work under a grant including: (i) all "direct charge" employees; (ii) all
"indirect charge" employees unless their impact or involvement is insignificant
to the performance of the grant; and, (iii) temporary personnel and consultants
who are directly engaged in the performance of work under the grant and who are
on the grantee's payroll. This definition does not include workers not on the
payroll of the grantee (e.g., volunteers, even if used to meet a matching
requirement; consultants or independent contractors not on the grantee's
payroll; or employees of subrecipients or subcontractors in covered workplaces).

                                       3
<PAGE>

                                                                      Appendix J

                        U.S. DEPARTMENT OF AGRICULTURE
                         AGRICULTURAL RESEARCH SERVICE

________________________________________________________________________________

                             NOTICE TO APPLICANTS
                     Certification/Disclosure Requirements
                              Related to Lobbying

________________________________________________________________________________

Section 319 of Public Law 101-121 (31 U.S.C.), signed into law on October 23,
1989, imposes new prohibitions and requirements for disclosure and certification
related to lobbying on recipients of Federal contracts, grants, cooperative
agreements, and loans. Certain provisions of the law also apply to Federal
commitments for loan guarantees and insurances; however, it provides exemptions
for Indian tribes and tribal organizations.

Effective December 23, 1989, current and prospective recipients (and their
subtier contractors and/or subgrantees) will be prohibited from using Federal
funds, other than profits from a Federal contract, for lobbying Congress or any
Federal agency in connection with the award of a particular contract, grant,
cooperative agreement or loan. In addition, for each award action in excess of
$100,000 (or $150,000 for loans) on or after December 23, 1989, the law requires
recipients and their subtier contractors and/or subgrantees to: (1) certify that
they have neither used nor will use any appropriated funds for payment to
lobbyists, (2) disclose the name, address, payment details, and purpose of any
agreements ,with lobbyists whom recipients or their subtier contractors or
subgrantees will pay with profits or nonappropriated funds on or after December
23, 1989; and (3) file quarterly updates about the use of lobbyists if material
changes occur in their use. The law establishes civil penalties for
noncompliance.

If you are a current recipient of funding or have an application, proposal or
bid pending as of December 23, 1989, the law will have the following immediate
consequences for you:

- -    You are prohibited from using appropriated funds (other than profits from
Federal contracts) on or after December 23, 1989, for lobbying Congress or any
Federal agency in connection with a particular contract, grant, cooperative
agreement, or loan;

- -    you are required to execute the attached certification at the time of
submission of an application or before any action in excess of $100,000 is
awarded; and

- -    you will be required to complete the lobbying disclosure form if the
disclosure requirements apply to you.

Regulations implementing Section 319 of Public Law 101 - 121 have been published
as an Interim Final Rule by the Office of Management and Budget as Part III of
the February 26, 1990 Federal Register (pages 6736-6746).

                                  Page 1 of 5
<PAGE>

                                                                      Appendix J

                        U.S. DEPARTMENT OF AGRICULTURE
                         AGRICULTURAL RESEARCH SERVICE


________________________________________________________________________________

             Certification Regarding Lobbying - Contracts, Grants,
                       Loans and Cooperative Agreements
________________________________________________________________________________

The undersigned certifies to the best of his or her knowledge and belief, that:

(1)  No Federal appropriated funds have been paid or will be paid, by or on
behalf of the undersigned, to any person for influencing or attempting to
influence an officer or employee of any agency, a Member of Congress, an officer
or employee of Congress, or an employee of a Member of Congress in connection
with the awarding of any Federal contract, the making of any Federal grant, the
making of any Federal loan, the entering into of any cooperative agreement, and
the extension, continuation, renewal, amendment, or modification of any Federal
contract, grant, loan or cooperative agreement.

(2)  If any funds other than Federal appropriated funds have been paid or will
be paid to any person for influencing or attempting to influence an officer or
employee of any agency, a Member of Congress, an officer or employee of
Congress, or an employee of a Member of Congress in connection with this Federal
contract, grant, loan, or cooperative agreement, the undersigned shall complete
and submit Standard Form-LLL, "Disclosure Form to Report Lobbying," in
accordance with its instructions;

(3)  The undersigned shall require that the language of this certification be
included in the award documents for all subawards at all tiers (including
subcontracts, subgrants, and contracts under grants, loans, and cooperative
agreements) and that all subrecipients shall certify and disclose accordingly.

This certification is a material representation of fact upon which reliance was
placed when this transaction was made or entered into. Submission of this
certification is a prerequisite for making or entering into this transaction
imposed by section 1352, title 31, U.S. Code. Any person who fails to file the
required certification shall be subject to a civil penalty of not less than
$10,000 and not more than $100,000 for each such failure.


        SEQUENOM                                        58-5438-9-120
- --------------------------------------------------------------------------------
Organization Name                               Award Number or Project Name



         Dr. Toni Schuh, Executive Vice President, Business Development
- --------------------------------------------------------------------------------
Name and Title of Authorized Representative


                                                          May 13, 1999
- --------------------------------------------------------------------------------
Signature                                                 Date

                                  Page 2 of 5
<PAGE>

                                                                      Appendix J

                       DISCLOSURE OF LOBBYING ACTIVITIES
Complete this form to disclose lobbying activities pursuant to 31 U.S.C. 1352.
                  (See reverse for public burden disclosure.)

<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------------------------------------
<S>                                      <C>                                    <C>
1.  Type of Federal Action:              2. Status of Federal Action:           3. Report Type:
[_]      a. contract                     [_]     a. bid/offer/application       [_]    a. initial filing
         b. grant                                b. initial award                      b. material change
         c. cooperative agreement                c. post award
         d. loan                                                                       For Material Change Only
         e. loan guarantee                                                             year ___  quarter ___
         f. loan insurance                                                             date of last report
- ----------------------------------------------------------------------------------------------------------------------
4. Name and Address of Reporting Entity:                     5. If Reporting in No. 4 is Subawardee,
                                                                 Enter Name and Address of Prime:
    [_]  Prime             [_] Subawardee
                                Tier ___, if known:



                                                             Congressional District, if known:
Congressional District, if known:
- ----------------------------------------------------------------------------------------------------------------------
6. Federal Department/Agency:                                7. Federal Program Name/Description:



                                                             CFDA Number, if applicable:
- ----------------------------------------------------------------------------------------------------------------------
8. Federal Action Number, if known:                          9. Award Amount, if known:



- ----------------------------------------------------------------------------------------------------------------------
10. a.  Name and Address of Lobbying Entity                  b.  Individuals Performing Services (including address
      (if individual, last name, first name MI)                   if different from No. 10a)
                                                                  (last name, first name, MI):




                                (attach Continuation Sheet(s) SF-lll-A, if necessary)
- ----------------------------------------------------------------------------------------------------------------------
11.   Amount of Paycheck (check all that apply):                   13. Type of Payment (check all
      that apply): $__________________ [_] actual [_] planned          [_] a. retainer
                                                                       [_] b. on-time fee
                                                                       [_] c. commission
                                                                       [_] d. contingent fee
                                                                       [_] e. deferred
                                                                       [_] f. other; specify:__________
- ----------------------------------------------------------------------------------------------------------------------
12. Form of Payment (check all that apply): [_] a. cash

    [_] b. in-kind; specify:        nature __________
                                    value  __________
- ----------------------------------------------------------------------------------------------------------------------
14. Brief Description of Services Performed or to be Performed and Date(s) of Service, including officer(s),
 employee(s), or Member(s) contacted, for Payment indicated in Item 11;





                                (attach Continuation Sheet(s) SF-LLL-A, if necessary)
- -----------------------------------------------------------------------------------------------------------------------
15. Continuation Sheet(s) SF-LLL-A attached:                  [_] Yes                   [_] No
- -----------------------------------------------------------------------------------------------------------------------
16. Information requested through this form is authorized  by Title 31   Signature:________________________________
    U.S.C. section 1352. This disclosure of lobbying activities
    is a material representation of  fact upon which reliance was        Print Name:_______________________________
    placed by the tier above when this transaction was made or
    entered into. This disclosure is required pursuant to 31             Title:____________________________________
    U.S.C. 1352. This information will be available for public
    inspection.  Any person who fails the required                       Telephone No.:_________________Date:______
    disclosure shall be subject to a civil penalty of not
    less than $10,000 and not more than $100,000 for each
    such failure.
- -----------------------------------------------------------------------------------------------------------------------
Federal Use Only                                                                  Authorized for Local Reproduction
                                                                                  Standard Form - LLL
- -----------------------------------------------------------------------------------------------------------------------
</TABLE>

                                  Page 3 of 5
<PAGE>

   Instructions for Completion of SF-LLL, Disclosure of Lobbying Activities
   ------------------------------------------------------------------------

This disclosure form shall be completed by the reporting entity, whether
subawardee or prime Federal recipient, at the initiation or receipt of a covered
Federal action, or a material change to a previous filing, pursuant to Title 31
U.S.C., Section 1352. The filing of a form is required for each payment or
agreement to make payment to any lobbying entity for influencing or attempting
to influence an officer or employee of any agency, a Member of Congress, an
officer or employee of Congress, or an employee of a Member of Congress in
connection with a covered Federal action. Use the SF-LLL-A Continuation Sheet
for additional information if the space on the form is inadequate. Complete all
items that apply for both the initial filing and material change report. Refer
to the implementing guidance published by the Office of Management and Budget
for additional information.

1.   Identify the type of Federal covered action for which lobbying activity is
and/or has been secured to influence the outcome of a covered Federal action.

2.   Identify the status of the Federal covered action.

3.   Identify the appropriate classification of this report. If this is a
followup report caused by a material change to the information previously
reported, enter the year and quarter in which the change occurred. Enter the
date of the last previously submitted report by this reporting entity for this
covered Federal action.

4.   Enter the full name, address, city, state and zip code of the reporting
entity. Include Congressional District, if known. Check the appropriate
classification of the reporting entity that designates if it is, or expects to
be, a prime or subaward recipient. Identify the tier of the subawardee, e.g.,
the first subawardee of the prime is the 1st tier. Subawards include but are not
limited to subcontracts, subgrants, and contract awards under grants.

5.   If the organization filing the report in item 4 checks "Subawardee", then
enter the full name, address, city, state and zip code of the prime Federal
recipient. Include the Congressional District, if known.

6.   Enter the name of the Federal agency making the award or loan commitment.
Include at least one organizational level below agency name, if known. For
example, Department of Transportation, United States Coast Guard.

7.   Enter the Federal program name or description for the covered Federal
action (item 1). If known, enter the full Catalog of Federal Domestic Assistance
(CFDA) for grants, cooperative agreements, loans, and loan commitments.

8.   Enter the most appropriate Federal identifying number available for the
Federal action identified in item 1 (e.g. Request for Proposal (RFP) number;
Invitation for Bid (IFB) number; grant announcement number; the contract, grant,
or loan award number, the application/proposal control number assigned by the
Federal agency). Include prefixes, e.g., "RFP-DE-90-001."

9.   For a covered Federal action where there has been an award or loan
commitment by the Federal agency, enter the Federal amount of the award/loan
commitment for the prime entity identified in item 4 or 5.

10.  (a) Enter the full name, address, city, state and zip code of the lobbying
     entity engaged by the reporting entity identified in item 4 to influence
     the covered Federal action.

     (b)    Enter the full names of the individual(s) performing services, and
     include full address if different from 10(a). Enter Last Name, First Name,
     and Middle Initial (MI).

11.  Enter the amount of compensation paid or reasonably expected to be paid by
the reporting entity (item 4) to the lobbying entity (item 10). Indicate whether
the payment has been made (actual) or will be made (planned). Check all boxes
that apply. If this is a material change report, enter the cumulative amount of
payment made or planned to be made.

12.  Check the appropriate box(es). Check all boxes that apply. If payment is
made through an in-kind contribution, specify the nature and value of the
in-kind payment.

13.  Check the appropriate box(es). Check all boxes that apply. If other,
specify nature.

14.  Provide a specific and detailed description of the services that the
lobbyist has performed, or will be expected to perform, and the date(s) of any
services rendered. Include all preparatory and related activity, not just time
spent in actual contact with Federal officials. Identify the Federal official(s)
or employee(s) contacted or the officer(s), employees), or Member(s) of Congress
that were contacted.

15.  Check whether or not a SF-LLL-A Continuation Sheet(s) is attached.

16.  The certifying official shall sign and date the form, print his/her name,
title, and telephone number.

________________________________________________________________________________

Public reporting burden for this collection of information is estimated to
average 30 minutes per response, including time for reviewing instructions,
searching existing data resources, gathering and maintaining data needed, and
completing and reviewing the collection of information. Send comments regarding
the burden estimate or any other aspect of this collection of information,
including suggestions for reducing this burden, to the Office of Management and
Budget, Paperwork Reduction Project (0348-0046), Washington, D.C. 20503.

________________________________________________________________________________


                                  Page 4 of 5
<PAGE>

                       DISCLOSURE OF LOBBYING ACTIVITIES
                              CONTINUATION SHEET

_______________________________________________________________________________
Reporting Entity:_________________________________________ Page ___ of ____









________________________________________________________________________________
Federal Use Only                         Authorized for Local Reproduction
                                         Standard Form - LLL - A
________________________________________________________________________________

                                  Page 5 of 5
<PAGE>

                                                                      Appendix L
                      Report of Inventions and Subawards

A.   General
     -------

     1.    The Cooperator shall submit interim and final invention reports and
           promptly give notification of the award of subawards containing a
           "Patent Rights" clause. Plains sheets of paper may be used to make
           these reports.

     2.    An interim report is due at least every 12 months from date of award
           and every 12 months thereafter.

     3.    A final report is due within 6 months of termination if the
           Performing Organization is a small business firm or a domestic non-
           profit organization and within 3 months for all others.

B. Interim and Final Reports must contain:
- ------------------------------------------

     1.    Name of Performing Organization.
     2.    Research Agreement Number.
     3.    Research Agreement award date.
     4.    Type of Report (Interim or Final).
     5.    Reporting Period.
     6.    Report of Inventions and Subawards content.
     7.    A listing of all inventions made including:
           a.  The name of inventor(s).
           b.  The title of invention(s).
           c.  The disclosure number, patent application in the United
               States of foreign countries?
           d.  Has election been made to file patent applications in the United
               States of foreign countries?
           e.  Have confirmation instrument assignments been forwarded to
               ARS?

     8.    Certification or compliance with required invention identification
           and disclosure procedures and certification of reporting all
           inventions.

     9.    Any required information not previously reported on subawards
           containing a "Patent Rights" clause awarded during the course of the
           Cooperative Agreement.

C. Subaward Reports must contain:
   ------------------------------

     1.    Name of Performing Organization.
     2.    Cooperative Agreement Number.
     3.    Cooperative Agreement award date.
     4.    Type of Report (Interim or Final).
     5.    Report Period.
     6.    Name of subawardee or subawardees.
     7.    Complete address of subawardee or subawardees.
     8.    Subaward identification number or numbers.
     9.    The "Patent Rights" clause incorporated, including year and date of
           clause.
     10.   Description of work performed under subaward(s).
     11.   Date of subaward(s).
     12.   Estimated completion date(s).

D.   Negative reports are required.

     Department of Defense Form 882, Report of Inventions and Subcontracts
     may be used in lieu of the above narrative report.
<PAGE>

<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------------------------------------------
                            [REPORT OF INVENTIONS AND SUBCONTRACTS]                              FORM APPROVED
        (Pursuant to "Patent Rights" Contract Clause) (See Instructions on Reverse Side)         OMB NO_0704-0015
- -----------------------------------------------------------------------------------------------------------------------------------
<S>                        <C>                  <C>                      <C>                     <C>
1a. NAME OF CONTRACTOR/    C. CONTRACT NUMBER   2a. NAME OF GOVERNMENT   c. CONTRACT NUMBER      3. TYPE OF REPORT (check one)
SUBCONTRACTOR                                   PRIME CONTRACTOR                                 |_| Interim         |_| Final
- -----------------------------------------------------------------------------------------------------------------------------------
1b. ADDRESS (Include Zip   d. AWARD DATE        2b. ADDRESS (Include     d. AWARD DATE           4. REPORTING PERIOD (YY/MM)
Code)                      (YY/MM/DD)           Zip Code)                (YY/MM/DD)              FROM:           TO:
- -----------------------------------------------------------------------------------------------------------------------------------
                                                  SECTION 1 - SUBJECT INVENTIONS
- -----------------------------------------------------------------------------------------------------------------------------------
SUBJECT INVENTIONS" REQUIRED TO BE REPORTED BY CONTRACTOR/SUBCONTRACTOR (If "None" So State)
- -----------------------------------------------------------------------------------------------------------------------------------
NAME OF INVENTOR(S)        b. TITLE OF          c.  DISCLOSURE NO.       D. ELECTION TO FILE     C. CONFIRMATORY INSTRUMENT OR
(Last, First, Mi)          INVENTION(S)         PATENT APPLICATION       PATENT APPLICATIONS     ASSIGNMENT FORWARDED TO
                                                SERIAL NO. OR PATENT NO. ----------------------- CONTRACTING OFFICE
                                                                            UNITED     FOREIGN
                                                                            STATES
- -----------------------------------------------------------------------------------------------------------------------------------
                                                                           YES   NO     YES  NO      YES               NO
                                                                          ---------------------------------------------------------



- -----------------------------------------------------------------------------------------------------------------------------------
EMPLOYER OF INVENTOR(S) NOT EMPLOYED BY CONTRACTOR/SUBCONTRACTOR.        g. ELECTED FOREIGN COUNTRIES IN WHICH A PATENT APPLICATION
                                                                         WILL BE FILED.
- -----------------------------------------------------------------------------------------------------------------------------------
NAME OF INVENTOR           I. NAME OF INVENTOR  I.               TITLE OF INVENTION              II.       FOREIGN COUNTRIES
(Last, First, MI)          (Last, First, MI)                                                             OF PATENT APPLICATION
- -----------------------------------------------------------------------------------------------------------------------------------
NAME OF EMPLOYER           II. NAME OF EMPLOYER
- ------------------------------------------------
ADDRESS OF EMPLOYER        III. ADDRESS OF
(Include Zip code)         EMPLOYER (Include
                           Zip code)
- -----------------------------------------------------------------------------------------------------------------------------------
                                  SECTION II - SUBCONTRACTS (Containing a "Patent Rights" Clause)
- -----------------------------------------------------------------------------------------------------------------------------------
SUBCONTRACTS AWARDED BY CONTRACTOR/SUBCONTRACTOR (If "None" so state).
- -----------------------------------------------------------------------------------------------------------------------------------
NAME OF SUBCONTRACTOR(S)   b. ADDRESS (Include  c. SUBCONTRACT NO.(S)    d. DAR "PATENT RIGHTS"  e. DESCRIPTION  F. SUBCONTRACT
                           Zip Code)                                                             OF WORK TO BE   DATES
                                                                                                 PERFORMED          (YYMMDD)
                                                                         ----------------------------------------------------------
                                                                           CLAUSE        DATE    UNDER           AWARD   ESTIMATED
                                                                             NO.        (YYMM)   SUBCONTRACT(S)          COMPLETION
- -----------------------------------------------------------------------------------------------------------------------------------



- -----------------------------------------------------------------------------------------------------------------------------------
                                                    SECTION III - CERTIFICATION
- -----------------------------------------------------------------------------------------------------------------------------------
 CERTIFICATION OF REPORT BY CONTRACTOR/SUBCONTRACTOR. (Not required if |_| Small Business of |_| Non-Profit Organization). (Check
                                                         appropriate box).
- -----------------------------------------------------------------------------------------------------------------------------------
NAME OF CONTRACTOR/SUBCONTRACTOR OFFICIAL       c. I certify that the reporting party has procedures for prompt identification and
(Last, First, MI)                               timely disclosure of "Subject Inventions," that such procedures have been followed
                                                and that all "Subject Inventions" have been reported.

_______________     ______________________________                  _____________________      _________________________     ______
TITLE                                                               SIGNATURE OF AUTHOR        CONTRACTOR/SUBCONTRACTOR
- -----------------------------------------------------------------------------------------------------------------------------------
</TABLE>
<PAGE>

                                 INSTRUCTIONS

GENERAL

This form is for use in submitting INTERIM and FINAL invention reports to the
Contracting Officer and for use in the prompt notification of the award of
subcontracts containing a "Patent Rights" clause. If the form does not afford
sufficient space, multiple forms may be used or plain sheets of paper with
proper identification of information by Item may be attached.

An INTERIM report is due at least every 12 months from the date of contract
award and shall include (a) a listing of "Subject Inventions" during the
reporting period, (b) a certification of compliance with required invention
identification and disclosure procedures together with a certification of
reporting of all "Subject Inventions." and (c) any required information not
previously reported on subcontracts awarded during the reporting period and
containing a "Patent Rights" clause.

A FINAL report is due within 6 months if contractor is a small business firm of
domestic nonprofit organization and within 3 months for all others after
completion of the contract work and shall include (a) a listing of all "Subject
Inventions" required by the contract to be reported, and (b) any required
information not previously reported on subcontracts awarded during the course of
or under the contract and containing a "Patent Rights" clause.

While the form may be used for simultaneously reporting inventions and
subcontracts, it may also be used for reporting, promptly after award,
subcontracts containing a "Patent Rights" clause.

Dates shall be entered where indicated in certain Items on this form and shall
be entered in four or six digit numbers in the order of year and month (YYMM) or
year, month and day (YYMMDD). Example: April 1981 should be entered as 8104 and
April 15, 1981 should be entered as 810415.

Item la.            Self-explanatory.

Item 1b.            Self-explanatory.

Item lc.            If "same" as item 2c, so state.

Item 1d.            Self-explanatory.

Item 2a.            If "same" as item 1a, so state.

Item 2b.            Self-explanatory.

Item 2c.            Procurement Instrument Identification (PII) number of
                    contract (DAR 20-203).

Item 2d. thru 5c.   Self-explanatory.

Item 5f, ii and iii. The name and address of the employer of each inventor not
employed by the contractor subcontractor is needed inasmuch as the Government's
rights in a reported invention may not be determined solely by the terms of the
"Patent Rights" clause in the contract. Example (1): If an invention is made by
a Government employee assigned to work with a contractor, the Government rights
in such an invention will be determined under Executive Order 10096. Example
(2): I f an invention is made under a contract by joint inventors and one of the
inventors is a Government employee, the Government's rights in such an
inventor's interest in the invention will also be determined under Executive
Order 10096, except where the contractor is a small business or nonprofit
organization, in which case the provisions of Section 202(c) of P.L. 96-517 will
apply.

Item 5g, 1.  Self-explanatory.

Item 5g, ii. Self-explanatory with the exception that the contractor or
subcontractor shall indicate, if known at the time of this report, whether
application will be filed under either the Patent Cooperation Treaty (PCT) or
the European Patent Convention (EPC).
If such is known, the letters PCT or EPC shall be entered after each listed
country.

Item 6a. Self-explanatory.

Item 6b. Self-explanatory.

Item 6c. Self-explanatory.

Item 6d. Patent Rights Clauses are located in 37 CFR Part 401.

Item 6c. thru 7b.  Self-explanatory.

Item 7c. Certification not required by small business firms and domestic
nonprofit organizations
<PAGE>

<TABLE>
<S>                     <C>                                   <C>
[LOGO] United State     Research, Education, and Economics      Office of the Area Director
Department of           Agricultural Research Service           Grants and Agreements
Agriculture
                                                     Reply to:  1201 Oakridge Drive, Suite 150
                                                                Fort Collins, CO 80526-5562

April 28, 1999                                                  COM 970/229-5529
                                                                FAX 970/229-5531
                                                                E-mail: [email protected]
</TABLE>

SUBJECT:   Delegation as Authorized Departmental Officer's (ADO) Designated
           Representative (ADODR) and Instructions for
           Specific Cooperative Agreement No. 58-5438-9-120 with Sequenom, Inc.

TO:        Dr. Gary L. Bennett
           U.S. Meat Animal Research Center
           Clay Center, NE 68933

FROM:      James E. Quaratino
           Authorized Departmental Officer

You are hereby appointed the Authorized Departmental Officer's Designated
Representative (ADODR) for this Agreement. This appointment is effective until
expiration of the agreement including any extension or revocation by the
Authorized Departmental Officer (ADO). This appointment is specifically
delegated to you. None of the responsibilities may be redelegated to any other
individual without written approval of the ADO.

A.    The ADODR shall:

      1.   Complete Form OGE-450, Executive Branch Confidential Financial
           Disclosure Report. If you are required to complete such a form at
           this time, one will be provided to you by the ARS Ethics office.
           Questions regarding this may be directed to the Area Ethics Advisor
           at (970) 229-5595.

      2.   Represent the ADO in the administration and supervision of this
           Agreement within the limitations set forth in the Agreement and this
           Instruction. Actions reserved for the ADO are set forth below.

      3.   Promptly refer to the ADO any matter which may endanger performance
           of the Agreement that is outside your authority to resolve.

      4.   Become thoroughly familiar with and faithfully administer the terms
           and conditions of the Agreement including the General provisions
           (Form ARS-452), as applicable, and documents related thereto.

      5.   Ensure that the Agreement will not be used to avoid and/or subvert
           any recognized procurement, property, fiscal, and personnel policies
           and procedures.

      6.   Routinely monitor and evaluate performance under the Agreement
           to ensure that the project is satisfactorily progressing.
<PAGE>

Agreement No.: 58-5438-9-120                                         Page 2 of 5
Sequenom, Inc.
San Diego, CA


         7.    For non-Letter of Credit payment procedures, receive, verify, and
               recommend/not recommend claims for payment. Claims are billed:
               (1) for actual expenditures incurred, (2) at intervals in
               accordance with the terms and conditions of the Agreement, and
               (3) using vouchers prepared by the Cooperator with costs itemized
               by the budget categories agreed upon on the ARS-454, Cooperative
               Agreement Estimated Budget Form. The ADODR forwards the voucher,
               which indicates his/her payment recommendations, (signed and
               dated) to the ADO. The ADO approves or disapproves claims for
               advances or reimbursement.

         8.    Receive and approve or disapprove financial status reports and
               progress reports at the intervals agreed upon in the Agreement.
               Send copies to the ADO.

         9.    Receive reports, if any, of inventions made under the Agreement
               and forward them to the ADO.

         10.   Ensure that performance, time, and adequate funds are
               appropriately allocated to complete a project.

         11.   Ensure that two copies of the Final Report and publications
               generated under this Agreement, if any, are sent to the National
               Agricultural Library, Acquisitions and Serials Branch. Notice of
               dissemination of the Final Report, with a copy of the Final
               Report and, as appropriate, publications sent to the Library
               shall be forwarded to the ADO for placement in the official
               Agreement file. These submissions are to state the Agreement
               number and Cooperator's name on the document.

         12.   Advise the ADO should there be any discriminatory acts observed
               or suggested by a party to the Agreement.

         13.   Receive notices from the cooperator regarding actual or potential
               labor disputes which would affect the performance under the
               Agreement and immediately forward such notices to the ADO with
               comments regarding the impact of the dispute on the Agreement.

         14.   Establish and maintain an administrative file of all documents
               related to the implementation and administration of the
               Agreement.

         15.   Sixty days (60) prior to expiration, review to determine the
               current relevancy of the project to ARS program mission for the
               purpose of renewing, amending or terminating the agreement.

         16.   Questions regarding the responsibilities and duties of the ADODR
               or interpretation of any of the terms and conditions of the
               Agreement are referred to the ADO.

NOTE: Discrimination on the basis of race, religion, color, sex, national
origin, age, physical disability, political beliefs, and martial or familial
status is prohibited.
<PAGE>

Agreement No.: 58-5438-9-120                                         Page 3 of 5
Sequenom, Inc.
San Diego, CA


B.     Responsibilities Reserved to the ADO:

       1.    Upon recommendations by the ADODR, proposed amendments providing
             for:

             a.     Changes, including additions, deletions and/or extensions to
                    or termination of the work to be performed under the
                    Agreement by either party.

             b.     Changes of Principal Investigator (PI) for a period in
                    excess of three consecutive months.

             c.     Increases or decreases to the Federal Obligation amount or
                    amount of the contribution by the Cooperator.

             d.     Subcontract awards to third parties for performing all or
                    any portion of the Agreement (see General Provisions, Form
                    ARS-452)

             e.     Approval of purchases for general-purpose equipment and/or
                    special purpose equipment costing $5,000 or more, printing
                    and binding, audiovisual materials or service, (see General
                    Provisions, Form ARS-452).

             f.     Approval of the acquisition of nonexpendable equipment,
                    computer services or equipment.

             g.     Approval for travel outside the United States, its
                    possessions, territories, and Canada (applicable to domestic
                    cooperators only) or special or mass movements of personnel.

       2.    Assures that reports on inventions are forwarded to the ARS, Patent
             Program Coordinator. (Not applicable to negative reports).

C.     Decisions on Disputes and Other Administrative Problems Arising during
       this Cooperative Agreement

       Disputes regarding the authorities and responsibilities of the ADODR and
       the ADO must be submitted in writing to the ADODR. The cooperator must
       submit questions related to disputes or other problems directly to the
       ADO provided a copy is also sent to the ADODR. Problems that cannot be
       resolved between the ADO, ADODR, and the cooperator shall be submitted to
       the Director, Extramural Agreements Division, for resolution.
<PAGE>

Agreement No.: 58-5438-9-120                                         Page 4 of 5
Sequenom, Inc.
San Diego, CA



                                Acknowledgment

The following acknowledgment of receipt of this designation is provided for
completion by the Authorized Departmental Officer's Designated Representative
(ADODR).

Please sign and return a copy to:

         USDA, ARS, NPA
         Extramural Agreements
         1201 Oakridge Dr., Suite 150
         Fort Collins, CO 80525



I acknowledge receipt of the ADODR designation.




Gary L. Bennett
- ----------------------------------------------------------------------
ADODR Signature/SSN                        Date


cc:
USDA, ARS, Ethics Office

<PAGE>

                                                                   EXHIBIT 10.35

                             BECKMAN COULTER, INC.



                                    --and--



                                Sequenom, Inc.



                             OEM Supply Agreement

                                                                          Page 1
<PAGE>

TABLE OF CONTENTS

<TABLE>
<S>                                                                          <C>
1    DEFINITIONS..........................................................    3
2    PRICES...............................................................    4
3    SCOPE OF LICENSE GRANT...............................................    5
4    DISCOUNTS............................................................    4
5    ORDERS...............................................................    6
6    DELIVERY.............................................................    7
7    SHIPMENT AND RISK OF LOSS............................................    7
8    CERTIFICATION........................................................    8
9    CONDITIONS...........................................................    9
10   PRODUCT MODIFICATIONS................................................    9
11   PRODUCT ACCEPTANCE...................................................   10
12   PAYMENT..............................................................   10
13   LIMITED WARRANTY.....................................................   11
14   PROPRIETARY RIGHTS AND INDEMNIFICATION...............................   11
15   EXCLUSION AND DISCLAIMER OF ALL OTHER WARRANTIES.....................   12
16   LIMITATION OF REMEDIES AND LIABILITIES...............................   13
17   FORCE MAJEURE........................................................   14
18   EXPORT CONTROLS......................................................   14
19   GOVERNING LAW AND JURISDICTION.......................................   16
20   SOFTWARE LICENSES....................................................   15
21   TITLE & COPYRIGHT NOTICE.............................................   16
22   RENEWAL..............................................................   17
23   PUBLICITY............................................................   17
24   TERMINATION..........................................................   17
25   GENERAL..............................................................   18

EXHIBITS..................................................................   21
EXHIBIT A - PRODUCT DESCRIPTION...........................................   22
EXHIBIT B - SEQUENOM PRICING SCHEDULE.....................................   36
EXHIBIT C - JOINT RESEARCH AND DEVELOPMENT................................   37
EXHIBIT D - PRODUCT SPECIFICATIONS........................................   38
EXHIBIT E - SPARE PARTS LIST..............................................   39
</TABLE>

                                                                          Page 2
<PAGE>

1    DEFINITIONS

     a)   "Agreement" is defined as the BCI Original Equipment Manufacturer
          Agreement and includes all Exhibits and Schedules referred herein and
          attached hereto

     b)   "Anniversary Date" is 12 months from the last date in time adjacent to
          the signatures of the parties on the last page

     c)   "Exhibits" are those documents attached to, incorporated by reference
          in, or added to this Agreement at a later date which describe
          Products, support, or other business terms which are a part of this
          agreement.

     d)   "Original Equipment Manufacture" is the sale of Products and/or
          Software by BCI to Sequenom for the purpose of Sequenom incorporating
          such Products and/or software into the Sequenom System and the resale
          of such Products and/or software either as an integral part of the
          Sequenom System, or as repair or replacement parts for such Sequenom
          Systems.

     e)   "Sequenom" is Sequenom Inc., a Delaware Corporation having a place of
          business at 11555 Sorrento Valley Road, San Diego, California,
          92121-1331.

     f)   "Ordering Period" is the period commencing with the last date in time
          adjacent the signatures on the last page of this agreement and ending
          with the termination.

     g)   "Price List" is the list of the available Products and the prices for
          the country of installation of the Sequenom system containing the
          Product in effect on the date BCI accepts the Sequenom order for such
          product.

     h)   "Products" means the current specific Liquid Handling Device and/or
          accessories identified by BCI's part number's listed on Exhibit A
          attached hereto, a general description of which is set opposite each
          part number, Including the licenses and documentation required for the
          operation of the product.  Additional products and enhancements may be
          added to Exhibit A with the mutual written agreement of BCI and
          Sequenom.

     i)   "Software" is one or more programs, proprietary or licensed to BCI,
          which is either listed separately as a Software product on the Price
          List or included with a Product on the Price List.

     j)   "Sequenom System" means the proprietary system developed by or for
          Sequenom, manufactured by or for Sequenom and sold by Sequenom
          directly to end user's or to dealer-s or distributors for resale to
          end users

                                                                          Page 3
<PAGE>

2    PRICES

     a)   Sequenom shall pay BCI the list prices in effect at the point of
          installation for the Products and Software covered by this agreement
          described in Exhibit A. The discounts as shown in Exhibit B will be
          applicable at time of purchase and will be in effect until termination
          of this agreement.

     b)   The prices are FOB BCI's loading dock and do not include freight,
          insurance, duties, custom brokers or any other special packaging or
          handling.  Prices for European destinations include freight, duty and
          handling the nearest BCI affiliate.

     c)   Taxes are not included in prices and will be Invoiced as separate
          items in addition to the Products' sale/license price.

     d)   BCI may, by written notice to Sequenom, change (increase or decrease)
          the current list prices at the point of destination, change the
          transportation terms, terms of payment, minimum requirements per
          shipment or any other of the terms and conditions in the agreement
          covering the sale/license of the Products, only during a period of
          sixty (60) days prior to the annual Anniversary Date of this
          agreement.  Sequenom's failure to object to any change, In writing,
          received by BCI prior to the effective date of the change shall be
          considered to be acceptance.  BCI will advise Sequenom within fifteen
          (15) days from receipt of timely written objection from Sequenom
          whether BCI will (a) continue to supply on terms and conditions in
          effect prior to the announced change or (b) enter Into negotiations
          with Sequenom or (c) cancel if Sequenom refuses to accept the change.
          If BCI elects to enter into negotiations under (b) of the preceding
          sentence, and if within thirty (30) days from the date of BCI's
          proposed change an agreement has not been reached and BCI has not
          agreed to continue to supply on the terms and conditions in effect
          prior to the announced change, then either party may by written notice
          terminate the negotiations and cancel this Agreement.  Unless as
          otherwise agreed as part of the negotiation, price and other terms
          applicable during the negotiation pedod shall be those in effect prior
          to the announced change.


3    SCOPE OF LICENSE GRANT

     Subject to Paragraphs 20 and 21, BCI hereby grants to Sequenom and Sequenom
     accepts a /***/ right and license to: (a) resell the Products as part of
     the Sequenom System, and (b) the right to use and prepare derivative works
     of the Software and to sell and license such software and derivative works
     of the Sequenom System.  For the avoidance of doubt the foregoing rights
     and licenses does not include the right to sell the Product itself or the
     Software itself, other than as a part of the Sequenom System or as a

     /***/ Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                                                          Page 4
<PAGE>

     repair or a replacement part for the Sequenom System sold to an owner of a
     Sequenom System.

4    DISCOUNTS

     Sequenom Sales Incentives, attached as Exhibit B, may be instituted,
                                            ---------
     changed or withdrawn only during a period of sixty (60) days prior to the
     annual Anniversary Date of this agreement by prior written notice to
     Sequenom. The procedures set forth in Paragraph 2 (d) shall apply to any
     such change of the Sequenom Sales Incentives.

5    ORDERS

     a)   Sequenom agrees to and shall during the first twelve (12) months of
          this agreement order, purchase and take /***/ Multimek Liquid Handlers
          specified in Exhibit A, and BCI agrees to and shall manufacture sell
          and deliver such Handlers. Such purchase and sale shall be under the
          terms of this Agreement. Forecasted quantities to be ordered by
          Sequenom during the second and third years of this Agreement shall be
          agreed upon not later than 90 days prior to the expiration of the
          current year. Pricing for the quantities ordered during years two and
          three will be based on the quantities ordered and the Price List of
          Exhibit B.

     b)   Orders for Products and Software must reference this Agreement, be
          issued during the applicable Ordering Period, and specify delivery
          within 90 days from order date.  All such orders are subject to
          acceptance by BCI,

     c)   Sequenom will issue orders from one location within its organization
          and will specify "Ship To" addresses within the country where the
          order is placed, unless otherwise mutually agreed.

     d)   All orders for Products and Software accepted by BCI are firm and
          non-cancelable

6    DELIVERY

     Subject ot Paragraph 5(a), BCI shall sell and supply to Sequenom, and
     Sequenom shall purchase and take delivery from BCI, such quantity of
     Products and Software as Sequenom may require for current use during each
     Ordering Period.  Delivery is subject to acceptance of the order by BCI and
     to availability of the Products at the time Sequenom's order is received.
     BCI will make commercially reasonable efforts to meet delivery dates quoted
     or acknowledged, and to coordinate such delivery dates with Sequanom.

     /***/ Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                                                          Page 5
<PAGE>

7    SHIPMENT AND RISK OF LOSS

     a)   BCI will ship according to BCI standard commercial practice.  Special
          packing or shipping instructions requested by Sequenom must be agreed
          to by BCI in writing, and charges will be billed separately to
          Sequenom.

     b)   All shipments by BCI shall be FOB BCI's point of manufacture in the
          United States, except for European orders, which shall be FOB BCI's
          affiliate.  Title to and risk of loss for the products shall pass to
          Sequenom upon delivery by BCI to a carrier designated by Sequenom and
          selected by BCI if Sequenom does not designate a carrier.


8    CERTIFICATION

Sequenom hereby certifies that:

     a)   It is experienced in the use and operation of the Products and will be
          primarily responsible for the marketing and support of the products to
          Sequenom Customers.  Sequenom may request marketing assistance from
          BCI.  BCI will supply such assistance subject to a written agreement
          between the parties setting out the terms and conditions for such
          assistance.

     b)   It is an Independent Agreement or, not an agent or legal
          representative of BCI, and that any representation made or agreements
          executed by Sequenom with third parties will be Sequenom's sole
          responsibility.

     c)   The Products will be Incorporated in a Sequenom System consisting of a
          substantial amount of other hardware and/or software which Sequenom
          manufactures, develops, or, in the case of software, acquires the
          right to license or sub-license ("Added Value") and which Sequenom
          sells or leases to end-user's (other than Sequenom's corporate parent,
          division, or any subsidiary of corporate parent) in the regular course
          of business.  This Added Value represents a significant functional and
          value enhancement to the Products and Software.  If Sequenom's Added
          Value consists of software, the software solves a major application
          need for the products being purchased.

                                                                          Page 6
<PAGE>

     d)   It is responsible for maintaining support services for the entire
          Sequenom System.

     e)   It is responsible for complying with all training requirements
          designated by BCI on each Product and Software Sequenom carries.  All
          Sequenom personnel servicing the Products supplied by BCI will be
          trained either by BCI or Sequenom on the Products within 30 days of
          beginning work on any project involving Products supplied by BCI.  The
          cost of any additional training that is not provided with the standard
          purchase package of the Products supplied by BCI is the responsibility
          of Sequenom.


9    CONDITIONS

     a)   Discounts are available only for the Products listed on Exhibit A of
          this Agreement.

     b)   Sequenom will have no claim against BCI for compensation or commission
          from any sale, lease, license or transfer of the Products, or any
          portion thereof, by BCI or a third party to Sequenom Customers.

     c)   BCI reserves the right, at its discretion and upon reasonable notice
          to Sequenom, to verify Sequenom's compliance with the terms of this
          Agreement. At BCI's request, Sequenom will provide BCI with
          information to substantiate that Sequenom has fulfilled its
          obligations under this terms of this Agreement.

     d)   Sequenom reserves the right, at its discretion and upon reasonable
          notice to BCI, to verify BCI's compliance with the terms of this
          Agreement.  At Sequenom's request, BCI will provide Sequenom with
          information to substantiate that BCI has fulfilled its obligations
          under this terms of this Agreement.

10   PRODUCT MODIFICATIONS

     Sequenom will submit in writing to BCI any proposed Product changes which
     might affect either the performance, safety or radiated emissions
     certifications of the Products.  In the event BCI believes such changes may
     have an adverse effect, BCI and Sequenom shall make the necessary
     modifications to the warranty, specifications and liability provisions, if
     any, of this Agreement before such changes to the Product are made to
     thereby recognize such changes are made by Sequenom at its sole liability
     and responsibility and against the advice of BCI.

                                                                          Page 7
<PAGE>

11   PRODUCT ACCEPTANCE

     Product installation is included in the purchase price.  Acceptance of the
     Products and Software sold hereunder by Sequenom will be, presumed unless
     Sequenom notifies BCI within thirty (30) days after delivery that the
     product does not meet the product specifications of Exhibit D. If BCI
     agrees with Sequenom's test results It will repair or replace at BCI's
     option, the affected product or Software in the most expeditious manner
     available.  The foregoing is Sequenom's sole and exclusive remedy and BCI's
     sole and exclusive obligation.

12   PAYMENT

     a)   Payment will be due 30 days from the date of BCI's invoice.  Charges
          for Service Agreement Support services will be invoiced in advance.
          BCI may change credit terms by providing written notice of the change.

     b)   A charge of 11/2% of the unpaid balance per month will be applied for
          accounts open past thirty (30) days of invoice date.  Sequenom agrees
          to pay all costs of collecting any sums due to BCI hereunder,
          including but not limited to legal fees and expenses.

     c)   If Sequenom fails to pay any sum when due or fails to perform under
          this Agreement with BCI after 10 days written notice, BCI may
          discontinue performance under this Agreement.

     d)   Sequenom hereby grants BCI a security interest in the Products and in
          any proceeds as security for its obligations under this Agreement.
          Sequenom shall assist and cooperate fully with BCI in any Uniform
          Commercial Code (UCC) filing requested by BCI to perfection and
          enforcement of such security interest.

13   LIMITED WARRANTY

     BCI warrants to Sequenom that, /***/ the date of installation of the
     Products, the Products so long as they remain unchanged and in the original
     condition supplied by BCI will be free from defects in materials and
     workmanship and shall conform to the specifications of attached Exhibit D.
     BCI's sole obligation and liability for any breach of the warranty shall be
     at BCI's sole option: (1) to replace the Products or Software, in whole or
     in any part, provided Sequenom or Sequenom's Customer returns the Products
     or Software, at BCI's expense, to be replaced; or (2) to repair or correct
     the Products or Software, in whole or in any part; or (3) to refund the
     applicable fee paid for the defective Product or Products, in whole or in
     any part, which shall be deemed to be

     /***/ Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                                                          Page 8
<PAGE>

     termination of the License, if the fee is for the Products or Software as a
     whole. The foregoing states Sequenom's sole and exclusive remedy and BCI's
     sole and exclusive responsibility with respect to any alleged breach of
     this limited warranty.

14   PROPRIETARY RIGHTS INDEMNIFICATION

     In the event of a claim or lawsuit brought by a third party based upon the
     Software use and\or the Product use, alone or in conjunction with or as
     part of the Sequenom System, in accordance with the Specifications of
     Exhibit D, infringes a trade secret, patent or copyright or other
     proprietary right of a third party, then BCI, Inc. shall, at BCI's sole
     discretion and option, do one of the following:

     a)   Procure for Sequenom the right to continue using the Software or
          Product; or

     b)   Modify the Software or Product to render it non-infringing; or,

     c)   Provide substitute, non-infringing software or product which performs
          substantially all of the functions and has substantially all of the
          features of the Software or Product; provided that, Sequenom may,
          after a thirty (30) day trial of the substitute software, reject the
          substitute software, terminate this Agreement and obtain a prorated
          refund in accordance with Subparagraph (d) hereof; or,

     d)   Terminate this Agreement and, if the term of the license was less than
          /***/ refund to Sequenom a prorate amount of the purchase price of the
          software or product paid by Sequenom based on a /***/ useful life with
          the /***/ commencing on the date on which software or product was
          received by Sequenom. The prorata amount that will be refunded to
          Sequenom shall be determined by multiplying the purchase price by
          Sequenom by a fraction, the numerator of the fractions shall be 1825
          minus the number of days that Sequenom had the use of the Software or
          Product and the denominator of which shall be 1825; or

     e)   Defend the lawsuit and indemnify Sequenom for any damages which may be
          awarded; provided that Sequenom provides prompt notice of the claim or
          lawsuit to BCI, (ii) Sequenom turns over to BCI the complete control
          of the defense of the lawsuit and any settlement or compromise
          thereof, (iii) Sequenom cooperates fully with BCI and provides BCI
          with such reasonable assistance, as BCI may request (at Beckman
          Coulter, Inc.'s sole cost) in the defense of such lawsuit, and (iv)
          Sequenom makes no admission or statements relative to the Software or
          Product and the third party intellectual property without the express
          written permission of BCI.

     /***/ Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

                                                                          Page 9
<PAGE>

15   EXCLUSION AND DISCLAIMER OF ALL OTHER WARRANTIES

     EXCEPT AS PROVIDED IN PARAGRAPH 13, THE PRODUCTS ARE PROVIDED WITHOUT
     WARRANTY OF ANY KIND OR NATURE. BCI DOES NOT WARRANT, GUARANTEE, OR MAKE
     ANY REPRESENTATIONS REGARDING THE USE OR THE RESULTS OF THE USE OF THE
     PRODUCTS IN TERMS OF CORRECTNESS, ACCURACY, RELIABILITY, CURRENTNESS, OR
     OTHERWISE. THE ENTIRE RISK AS TO THE RESULTS AND PERFORMANCE OF THE
     PRODUCTS IS ASSUMED BY SEQUENOM AND SEQUENOM'S CUSTOMERS. THE LIMITED
     WARRANTY CONTAINED IN PARAGRAPH 13 IS BCI'S SOLE WARRANTY WITH RESPECT TO
     THE PRODUCTS, SOFTWARE AND DOCUMENTATION AND ARE MADE IN LIEU OF AND
     EXCLUDE ANY OTHER WARRANTIES, WHETHER ORAL OR WRITTEN, EXPRESS OR IMPLIED
     OR CREATED BY THE UCC OR THE USEAGE IN THE INDUSTRY OR THE COURSE OF
     DEALINGS OF THE PARTIES, AS TO ANY MATTER WHATSOEVER, INCLUDING BUT NOT
     LIMITED TO THOSE CONCERNING MERCHANTABILITY OR FITNESS FOR A PARTICULAR
     PURPOSE.


16   LIMITATION OF REMEDIES AND LIABILITIES

     EXCEPT AS SET FORTH IN PARAGRAPH 13, BCI SHALL NOT BE LIABLE, TO ANY EXTENT
     WHATSOEVER, FOR ANY DAMAGES RESULTING FROM OR ARISING OUT OF THE USE OR
     PERFORMANCE OF THE PRODUCTS OR THE SOFTWARE PROVIDED FOR IN THIS AGREEMENT,
     REGARDLESS OF FORESEEABILITY OR THE FORM OF ACTION, WHETHER IN AGREEMENT,
     BREACH OF WARRANTY, TORT (INCLUDING NEGLIGENCE), STRICT LIABILITY OR
     OTHERWISE, AND INCLUDING BUT NOT LIMITED TO DAMAGES RESULTING FROM LOSS OF
     DATA, LOSS OF ANTICIPATED PROFITS, OR ANY SPECIAL, INDIRECT, DIRECT,
     INCIDENTAL OR CONSEQUENTIAL DAMAGES.


17   FORCE MAJEURE

     In the event of war, fire, flood, earthquake, strike, labor trouble,
     breakage of equipment, accident, dot, action of governmental authority and
     laws, rules, ordinances and regulations, act of God, or contingencies
     beyond the reasonable control of Sequenom or BCI, interfering with the
     production, supply or transportation of such party at the time respecting
     the Products and Software covered by this agreement, or in the event of
     Inability to obtain on usual and customary prices and terms any goods and
     components used in connection therewith, quantities so affected shall be
     eliminated from the agreement without liability, but the agreement shall
     otherwise remain unaffected. BCI may, during any period of shortage of
     such goods and components due to force majeure as defined herein, allocate
     its supply of such goods and components among the various users and
     Sequenom therefore in any manner which it deems appropriate; provided that


24-June-99      Confidential Information of Beckman Coulter, Inc.        Page 10
<PAGE>

     BCI shall have no obligation to obtain goods and components from a third
     party under conditions BCI deems unreasonable in order to supply BCI's
     excused shortfall; and provided further that any goods and components
     obtained by BCI from a third party solely for BCI's internal use are not
     subject to allocation.


18   EXPORT CONTROLS

     Sequenom understands and recognizes that the Products and Software, in
     whole or in part, may be subject to the Export Administration Regulations
     of The United States Department of Commerce and other United States
     government regulations relating to the export of technical data. All
     commodities, technology and software exported from the United States shall
     be exported in accordance with Export Administration Regulations.
     Diversion contrary to U.S. law is prohibited. Sequenom agrees to comply
     with all such regulations, including any future modifications thereof.


19   GOVERNING LAW AND JURISDICTION

     This Agreement shall be governed by, and construed under the Laws of the
     State of Califonia and the United States, without regard to conflicts of
     laws provisions thereof and without regard to the United Nations
     Conventions on Contracts for the International Sale of Goods. The sole
     jurisdiction and venue for actions related to the subject matter hereof
     shall be the State and U.S. Federal Courts having within their jurisdiction
     the location of BCI's principle place of business.


20   SOFTWARE LICENSES

     a)   For the purposes of this paragraph 20, the term "License" shall mean
          Software License.  The term "Use" means      ***
                                      ***

     b)   Upon payment of the applicable fee, Sequenom may  ***
                                      ***

     c)   Sequenom's License          ***
                                      ***

     d)   Software bundled with a hardware Product may be used only with that
          hardware in the configuration in which that Product is sold by BCI or
          subsequently upgraded by BCI.

     ***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

24-June-99      Confidential Information of Beckman Coulter, Inc.        Page 11
<PAGE>

     e)   Sequenom's License confers no title or ownership in the Software and
          no rights in any associated source code, and such license will not be
          construed as a sale of any rights in Software.

     f)   Sequenom's entire License In Software is transferable to Sequenom's
          Customer subject to payment to BCI of all fees by Sequenom.  Sequenom
          will immediately upon transfer deliver all copies of the Software to
          the party to whom the Software is transferred in accordance with this
          paragraph 20(f). License terms will be binding on involuntary
          transferees. Sequenom's license will automatically terminate upon any
          transfer. Any License duly transferred under this Agreement to
          Sequenom's Customer shall survive termination of this Agreement.

     g)   Sequenom may not reverse engineer, disassemble or decompile the
          Software without BCI's prior written consent.

     h)   BCI may terminate Sequenom's License in Software upon notice for
          failure to comply with any applicable License terms. In the event of
          termination of Sequenom's License for any other reason, Sequenom will
          destroy or return to BCI the Software and all copies of the Software
          immediately upon termination. Sequenom will remove and destroy all
          copies of the Software from any adaptation into which they are merged.
          This section does not apply to Software delivered to a Sequenom
          Customer pursuant to the sale of a Sequenom System to such customer.


21   TITLE & COPYRIGHT NOTICE

     Sequenom understands and agrees that the Products, in whole or in any part,
     constitute proprietary information of BCI. Sequenom acknowledges that the
     title to any form of intellectual property rights, confidential and
     proprietary information incorporated into or embodied by the Products and
     Software, firmware and documentation shall remain vested exclusively in
     BCI. All copyright, trademark, mask work, patent and other intellectual
     property rights in the Products or any part thereof including all
     modifications, additions, or extensions of the Products and Software, shall
     become vested exclusively In BCI. All copies of the software and
     derivative works of the software will, on the first screen, carry a notice
     of BCI's ownership of the software and any derivative works.


22   RENEWAL

     This Agreement will remain in effect for twelve (12) months from the last
     date in time adjacent the signatures of the authorized representatives of
     the parties on the last page of this Agreement. This Agreement shall be
     automatically renewed for successive twelve (12) month periods, subject to
     the provisions of Paragraph 24.

24-June-99      Confidential Information of Beckman Coulter, Inc.        Page 12
<PAGE>

23   PUBLICITY

     BCI agrees to allow Sequenom to publish, as long as this Agreement is in
     effect, the name of BCI as an authorized Original Equipment Manufacturer of
     the Products. BCI may, as long as this Agreement Is in effect, publicly
     state and publish that Sequenom is an authorized Original Equipment
     Manufacturer reseller of the Products.  The form of either publication
     shall be mutually agreed upon by both parties.


24   TERMINATION

     a)   Upon 30 days prior written notice, either party may terminate this
          Agreement at the end of an Ordering Period, or any extension thereof.
          Either party may also terminate this agreement at any time on thirty
          (30) days written notice in the event of a material breach of the
          terms of this Agreement, unless the other party cures such breach
          within such 30 days of Notice of Breach each party shall define with
          specificity the acts and sections of this Agreement which constitute
          such breach.

     b)   If either party becomes insolvent, is unable to pay its debts when
          due, files for bankruptcy, is the subject of involuntary bankruptcy,
          has a receiver appointed, or has its assets assigned, the other party
          may terminate this Agreement without notice and may cancel any
          unfulfilled obligations.

     c)   The provisions of paragraphs 3 and 8, 13, 14 and 21 will survive the
          termination or expiration of this Agreement.


25   GENERAL

     a)                                      ***
                                             ***

     b)                                      ***
                                             ***

     c)   If any provision of this agreement is held invalid or unenforceable,
          such invalidity shall not affect the other provisions or application
          of the Agreement which ran be given effect without the Invalid
          provision or application, and to this end the provisions of this
          Agreement are declared to be severable. If such invalidity becomes
          known or apparent to Sequenom and BCI, Sequenom and BCI agree to
          negotiate promptly in the good faith in an attempt to make appropriate
          changes and adjustments to achieve as closely as possible consistent
          with applicable law, the intent and spirit of such invalid provision.

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

24-June-99      Confidential Information of Beckman Coulter, Inc.        Page 13
<PAGE>

     d)   Neither party may assign any rights or obligations of this Agreement
          without prior written consent of the other party: provided that BCI
          may assign this Agreement to a successor in interest to all, or
          substanially all of the business or assets to which Agreement relates.

     e)   Neither party's failure to exercise any of its fights under this
          Agreement will constitute or be deemed a waiver or forfeiture of those
          rights.

     f)   This Agreement supersedes any previous communications, representations
          or agreements between the parties, whether oral or written, regarding
          transactions hereunder, excluding the current Confidentiality
          Agreement dated September 23, 1998. Sequenom's additional or
          different terms and conditions will not apply. This Agreement may not
          be changed except by an amendment signed by an authorized
          representative of each party.

     g)   Sequenom acknowledges that information and recommendations, Including
          but not limited to technical and marketing information and
          recommendations, are furnished by BCI without charge, and that BCI
          assumes no obligation or liability for the advice given or results
          obtained therefrom. Sequenom agrees to evaluate such information and
          recommendations using its own independent skill and expertise, and
          accepts all risks arising from the use or non-use of such Information
          and/or recommendations.

     h)   Sequenom agrees that the terms and conditions of this Agreement
          including Exhibits are not published by BCI and are confidential and
          will not be disclosed by Sequenom to any third party.


IN WITNESS WHEREOF, the undersigned have executed this Agreement this ____st day
Of ____________, 1999.


AGREED TO: AGREED TO:

AGREED TO:                                      AGREED TO:

Sequenom, Inc.                                  Beckman Coulter, Inc.
11555 Sorrento Valley Road                      4300 N. Harbor Blvd.
San Diego, California 92121-1331                Fullerton, California 92834-3100


By: /s/ Hubert Koster                           By: /s/ Detlef Sasse
    ---------------------                           -----------------
Name: Hubert Koster                             Name: Detlef Sasse
      -------------------                             ---------------
Title: President & CEO                          Title: Vice President
       ------------------                              --------------


24-June-99      Confidential Information of Beckman Coulter, Inc.        Page 14
<PAGE>

                                   EXHIBITS

       The Exhibits attached and listed below are part of this Agreement

                        EXHIBIT A - Product Description

                     EXHIBIT B - Sequenom Pricing Schedule

                  EXHIBIT C - Joint Research and Development

24-June-99     Confidential Information of Beckman Coulter, Inc.       Page 15
<PAGE>

                        EXHIBIT A - PRODUCT DESCRIPTION

The following Beckman Coulter products are available from BCI. When BCI has new
Standard Products to be added to this list, an amended exhibit will be
distributed.

Multimek(TM) US Product Description
Multimek(TM) 96 Systems


<TABLE>
<CAPTION>
- ----------------------------------------------------------------------------------------------------------------
Part No.                                        Included System Components                            Special
                                                                                                       Order
- ----------------------------------------------------------------------------------------------------------------
                        Multimek 96 Pipettor               Multimek    Five-      Fixed Tip   PC Controller
                                                             Pro      Position      Wash          477866
                                                           Software   Labware      System
                                                            147210      Deck       147235
                                                                       147220
- ----------------------------------------------------------------------------------------------------------------
<S>                 <C>                                    <C>        <C>         <C>         <C>     <C>
267777                       147201                           X          X                     X
                    200 (MU)L Disposable Tip Head,
                       Auto Tip Load Station,
                     Standard Config., 120 VAC
- ----------------------------------------------------------------------------------------------------------------
267778                       147203                           X          X
                    200 (MU)L Disposable Tip Head,
                       Auto Tip Load Station,
                     Standard Config., 240 VAC
- ----------------------------------------------------------------------------------------------------------------
267771                       147206                           X          X
                    200 (MU)L Disposable Tip Head,
                       Auto Tip Load Station,
                      Robotic Version, 120 VAC
- ----------------------------------------------------------------------------------------------------------------
267773                       147208                           X          X
                    200 (MU)L Disposable Tip Head,
                       Auto Tip Load Station,
                      Robotic Version, 240 VAC
- ----------------------------------------------------------------------------------------------------------------
267779                       147202                           X          X                     X         X
                    200 (MU)L Disposable Tip Head,
                       Auto Tip Load Station,
                     Standard Config., 120 VAC
- ----------------------------------------------------------------------------------------------------------------
267780                       147204                           X          X                               X
                    200 (MU)L Disposable Tip Head,
                       Auto Tip Load Station,
                     Standard Config., 120 VAC
- ----------------------------------------------------------------------------------------------------------------
267772                       147207                           X          X                               X
                    200 (MU)L Disposable Tip Head,
                       Auto Tip Load Station,
                      Robotic Version, 120 VAC
- ----------------------------------------------------------------------------------------------------------------
267774                       147209                           X          X                               X
                    200 (MU)L Disposable Tip Head,
                       Auto Tip Load Station,
                      Robotic Version, 240 VAC
- ----------------------------------------------------------------------------------------------------------------
</TABLE>

24-June-99     Confidential Information of Beckman Coulter, Inc.       Page 16
<PAGE>

Multimek(TM) 96 Automated Pipettors
U.S. Product Description

All pipettors must be ordered with Multimek Pro software, a PC Controller and a
Labware Deck. Disposable tip systems include Auto Tip Load Stations. Standard
Multimek 96 systems feature a plastic Safety Shield enclosing the work area.
Robotic versions have work areas enclosed with Light Curtains on the front and
back for compatibility with robotic access. All instruments with 20-(MU)L heads
are Special Order items which may have longer delivery times.

<TABLE>
<CAPTION>
- ---------------------------------------------------------------------------------------------
 Part No.   Description
- ---------------------------------------------------------------------------------------------
<C>         <S>
 147201     Multimek 96 Pipettor with Disposable Tip Dispense Head (200 (MU)L) Standard
            Configuration, 120 VAC.
- ---------------------------------------------------------------------------------------------
 147203     Multimek 96 Pipettor with Disposable Tip Dispense Head (200 (MU)L) Standard
            Configuration, 240 VAC.
- ---------------------------------------------------------------------------------------------
 147206     Multimek 96 Pipettor with Disposable Tip Dispense Head (200 (MU)L) Robotic
            Version, 120 VAC.
- ---------------------------------------------------------------------------------------------
 147208     Multimek 96 Pipettor with Disposable Tip Dispense Head (200 (MU)L) Robotic
            Version, 240 VAC.
- ---------------------------------------------------------------------------------------------
 147202     Multimek 96 Pipettor with Disposable Tip Dispense Head (20 (MU)L) Standard
            Configuration, i20 VAC.
- ---------------------------------------------------------------------------------------------
 147204     Multimek 96 Pipettor With Disposable Tip Dispense Head (20 (MU)L) Standard
            Configuration, 240 VAC.
- ---------------------------------------------------------------------------------------------
 147207     Multimek 96 Pipettor with Disposable Tip Dispense Head (20 (MU)L) Robotic
            Version, 120 VAC.
- ---------------------------------------------------------------------------------------------
 147209     Multimek 96 Pipettor with Disposable Tip Dispense Head (20 (MU)L) Robotic
            Version, 240 VAC.
- ---------------------------------------------------------------------------------------------
</TABLE>

Multimek(TM) 96 Required Accessories
U.S. Product Description

<TABLE>
<CAPTION>
- ---------------------------------------------------------------------------------------------
 Part No.   Description
- ---------------------------------------------------------------------------------------------
<C>         <S>
 147210     Multimek Pro Software - Software for programming and running pipetting methods.
- ---------------------------------------------------------------------------------------------
 477866     Multimek PC Controller - U.S. only.
            U.S. only. IBM Pentium 200 MHz, 32 MB RAM, 1 GB Hard Drive, 1.44 MB
            Floppy, 17" Monitor, Windows'95.
- ---------------------------------------------------------------------------------------------
 147220     Multimek 96 Labware Deck, Five Position
            Position #5 open. For use on disposable tip instruments without tip wash systems.
- ---------------------------------------------------------------------------------------------
</TABLE>

24-June-99     Confidential Information of Beckman Coulter, Inc.       Page 17
<PAGE>

<TABLE>
- -------------------------------------------------------------------------------------------
<S>         <C>
 147221     Multimek 96 Labware Deck, Four Position
- -------------------------------------------------------------------------------------------
            Positions #5 and #6 open.  For use on disposable tip Instruments with tip wash
            systems.
- -------------------------------------------------------------------------------------------
</TABLE>

Multimek(TM) 96 Optional Accessories
U.S. Product Description

<TABLE>
<CAPTION>
- -------------------------------------------------------------------------------------------
Part No.    Description
- -------------------------------------------------------------------------------------------
<S>         <C>
 147230     Disposable Tip Dispense Head - 200 (MU)L
- -------------------------------------------------------------------------------------------

- -------------------------------------------------------------------------------------------
 148027     20 (MU)L Disposable Tip Dispense Head Conversion Kit
- -------------------------------------------------------------------------------------------

- -------------------------------------------------------------------------------------------
 147233     Disposable Tip Wash System
            Includes wash station, wash pump, supply tank, and drain/waste tank.
            Uses position #6 on Multimek deck.
- -------------------------------------------------------------------------------------------
</TABLE>

Circulator Bath
U.S. Product Description

The Circulating Reservoir for the Multimek 96 provides a continuous supply of
buffer, solvent or reagent on the Multimek work surface. A peristaltic pump
circulates liquid between a 96-well reservoir on the Multimek Labware Deck and a
glass supply bottle. The reservoir can be placed at any available position on
the Labware Deck. Liquid temperature can be regulated by placing the supply
bottle in a user-supplied circulator bath.


148026      Multimek Circulating Reservoir Kit
            Includes: Circulating pump and two pump heads, 1.1 L supply bottle
            (148028), delivery cap (148030), 96-well reservoir for Multimek
            worksurface, Tygon and PharMed tubing and manual.

<TABLE>
<CAPTION>
- -------------------------------------------------------------------------------------------
 System Components
- -------------------------------------------------------------------------------------------
 Part No.   Description
- -------------------------------------------------------------------------------------------
<C>         <S>
 148028     1.1 L Reservoir Bottle
- -------------------------------------------------------------------------------------------
 148029     5.0 L Reservoir Bottle
- -------------------------------------------------------------------------------------------
 148030     Reservoir Delivery Cap
- -------------------------------------------------------------------------------------------
 148031     Tubing/Fitting Replacement Kit, Tygon
- -------------------------------------------------------------------------------------------
 148032     Tubing/Fitting Replacement Kit, PharMed
- -------------------------------------------------------------------------------------------
 148225     Multimek Teflon Circulation Reservoir
- -------------------------------------------------------------------------------------------
 148033     Multimek Teflon Reservoir, Stand-Alone; not recirculating
- -------------------------------------------------------------------------------------------
</TABLE>

24-June-99     Confidential Information of Beckman Coulter, Inc.       Page 18
<PAGE>

Multimek(TM) 96 Tips
U.S. Product Description

<TABLE>
<CAPTION>
- -------------------------------------------------------------------------------------------
 Part No.   Description
- -------------------------------------------------------------------------------------------
<C>         <S>
 148005     200 (MU)L Tips, Type 2, Nonsterile (Case of 10 Racks)
            For use on 20Q (MU)L Disposable Tip Dispense Head.
- -------------------------------------------------------------------------------------------
 267663     200 (MU)L Tips, Type 2, Nonsterile (Pallet of 125 Cases)
            For use on 200 (MU)L Disposable Tip Dispense Head.
- -------------------------------------------------------------------------------------------
 148004     200 (MU)L Tips, Type 2. Sterile (Case of 10 Racks)
            For use on 200 (MU)L Disposable Tip Dispense Head.
- -------------------------------------------------------------------------------------------
 267662     200 (MU)L Tips, Type 2, Sterile (Pallet of 125 Cases)
            For use on 200 (MU)L Disposable Tip Dispense Head.
- -------------------------------------------------------------------------------------------
 148003     50 (MU)L Tips, Type 2, Nonsterile (Case of 10 Racks)
            For use on 20 (MU)L Disposable Tip Dispense Head.
- -------------------------------------------------------------------------------------------
 267661     50 (MU)L Tips, Type 2, Nonsterile (Pallet of 125 Cases)
            For use on 20 (MU)L Disposable Tip Dispense Head.
- -------------------------------------------------------------------------------------------
 148003     50 (MU)L Tips, Type 2, Nonsterile (Case of 10 Racks)
            For use on 20 (MU)L Disposable Tip Dispense Head.
- -------------------------------------------------------------------------------------------
 267660     50 (MU)L Tips, Type 2, Sterile (Pallet of 125 Cases)
            For use on 20 (MU)L Disposable Tip Dispense Head.
- -------------------------------------------------------------------------------------------
 147252     20 (MU)L Tips, Type 1, Nonsterile (1 Nested Stack of 12 Sets of 96 Tips)
            For use on 20 (MU)L Disposable Tip Dispense Head.
- -------------------------------------------------------------------------------------------
 147243     P200 Type 2 Tip Hardware Conversion Kit
            For instruments having serial numbers prior to 304139.APS.
- -------------------------------------------------------------------------------------------
</TABLE>

Multimek(TM) 96 Parts and Supplies
U.S. Product Description

<TABLE>
<CAPTION>
- -------------------------------------------------------------------------------------------
 Part No.   Description
- -------------------------------------------------------------------------------------------
<C>         <S>
 147299     Multimek 96 Light Curtain Kit

            Components for utilizing a Multimek 96 on Beckman Coulter /SAGIAN integrated
            systems.
- -------------------------------------------------------------------------------------------
 148035     MultiPette Safety Upgrade Kit, Shield
- -------------------------------------------------------------------------------------------
 148036     MultiPette Safety Upgrade Kit, Light Curtain
- -------------------------------------------------------------------------------------------
 148094     Automatic Tip Loading Station - For 200 (MU)L Type 2 tips only.
- -------------------------------------------------------------------------------------------
 147205     Automatic Tip Loading Station - For 20 (MU)L Type 1 tips.
- -------------------------------------------------------------------------------------------
 147240     Deck Standoff Kit For use with 200 (MU)L Disposable Tip Head.
- -------------------------------------------------------------------------------------------
 147241     Deck Standoff Kit for Use with 20 (MU)L Disposable Tip Head
- -------------------------------------------------------------------------------------------
 147216     Multimek 96 Installation and Operations Binder
            Includes Installation and Maintenance Manual, Basic Training Manual and
            Tutorial Manual.
- -------------------------------------------------------------------------------------------
 147211     Multimek 96 Installation and Maintenance Manual
- -------------------------------------------------------------------------------------------
 147212     Multimek Pro Software Reference Manual
- -------------------------------------------------------------------------------------------
</TABLE>

24-June-99     Confidential Information of Beckman Coulter, Inc.       Page 19
<PAGE>

<TABLE>
<S>           <C>
- ------------------------------------------------------------------------------------------------
147225        Multimek 96 Tutorial Manual
- ------------------------------------------------------------------------------------------------
147260        P20 Tip Box, Aluminum Reusable - Does not include tips.
- ------------------------------------------------------------------------------------------------
147261        P20 Tip Box, Lightweight Reusable - Does not include tips.
- ------------------------------------------------------------------------------------------------
147262        P20 Tip De-Nester
              For easily de-nesting P20 tips into a reusable tip box for use on the Multimek 96.
- ------------------------------------------------------------------------------------------------
147263        Tip Transfer Tool, P200 - For transferring P200 tips from one tip box to another,
              96 at a time.
- ------------------------------------------------------------------------------------------------
147264        Tip Transfer Tool, P20 - For transferring P20 tips from one tip box to another,
              96 at a time.
- ------------------------------------------------------------------------------------------------
147330        Ball Screw Grease
- ------------------------------------------------------------------------------------------------
147295        Cleanout Needle for Fixed Tip Head
- ------------------------------------------------------------------------------------------------
147292        Wrench Kit
- ------------------------------------------------------------------------------------------------
</TABLE>

Multimek(TM) 96 Tips
U.S. Product Description

<TABLE>
<CAPTION>
- ------------------------------------------------------------------------------------------------
Part No.      Description
- ------------------------------------------------------------------------------------------------
<S>           <C>
148005        200 (MU)L Tips, Type 2, Nonsterile (Case of 10 Racks)
              For use on 200 (MU)L Disposable Tip Dispense Head.
- ------------------------------------------------------------------------------------------------
267663        200 (MU)L Tips, Type 2, Nonsterile (Pallet of 125 Cases)
              For use on 200 (MU)L Disposable Tip Dispense Head.
- ------------------------------------------------------------------------------------------------
148004        200 (MU)L Tips, Type 2, Sterile (Case of 10 Racks)
              For use on 200 (MU)L Disposable Tip Dispense Head.
- ------------------------------------------------------------------------------------------------
267662        200 (MU)L Tips, Type 2, Sterile (Pallet of 125 Cases)
              For use on 200 (MU)L Disposable Tip Dispense Head.
- ------------------------------------------------------------------------------------------------
148003        50 (MU)L Tips, Type 2, Nonsterile (Case of 10 Racks)
              For use on 20 (MU)L Disposable Tip Dispense Head.
- ------------------------------------------------------------------------------------------------
267661        50 (MU)L Tips, Type 2, Nonsterile (Pallet of 125 Cases)
              For use on 20 (MU)L Disposable Tip Dispense Head.
- ------------------------------------------------------------------------------------------------
148003        50 (MU)L Tips, Type 2, Nonsterile (Case of 10 Racks)
              For use on 20 (MU)L Disposable Tip Dispense Head.
- ------------------------------------------------------------------------------------------------
267660        50 (MU)L Tips, Type 2, Sterile (Pallet of 125 Cases)
              For use on 20 (MU)L Disposable Tip Dispense Head.
- ------------------------------------------------------------------------------------------------
147252        20 (MU)L Tips, Type 1, Nonsterile (1 Nested Stack of 12 Sets of 96 Tips)
              For use on 20 (MU)L Disposable Tip Dispense Head.
- ------------------------------------------------------------------------------------------------
147243        P200 Type 2 Tip Hardware Conversion Kit
- ------------------------------------------------------------------------------------------------
</TABLE>

24-June-99         Confidential Information of Beckman Coulter, Inc.     Page 20
<PAGE>

Multimek(TM) 96 Parts and Supplies
U.S. Product Description

<TABLE>
<CAPTION>
- ------------------------------------------------------------------------------------------------
Part No.      Description
- ------------------------------------------------------------------------------------------------
<C>           <S>
147299        Multimek 96 Light Curtain Kit
              Components for utilizing a Multimek 96 on Beckman Coulter /SAGIAN integrated
              systems.
- ------------------------------------------------------------------------------------------------
148035        MultiPette Safety Upgrade Kit, Shield
- ------------------------------------------------------------------------------------------------
148036        MultiPette Safety Upgrade Kit, Light Curtain
- ------------------------------------------------------------------------------------------------
148094        Automatic Tip Loading Station - For 200 (MU)L Type 2 tips only.
- ------------------------------------------------------------------------------------------------
147205        Automatic Tip Loading Station - For 20 (MU)L Type 1 tips.
- ------------------------------------------------------------------------------------------------
147240        Deck Standoff Kit
              For use with 200 (MU)L Disposable Tip Head.
- ------------------------------------------------------------------------------------------------
147241        Deck Standoff Kit for Use with 20 (MU)L Disposable Tip Head
- ------------------------------------------------------------------------------------------------
147216        Multimek 96 Installation and Operations Binder
              Includes Installation and Maintenance Manual, Basic Training Manual and Tutorial
              Manual.
- ------------------------------------------------------------------------------------------------
147211        Multimek 96 Installation and Maintenance Manual
- ------------------------------------------------------------------------------------------------
i47212        Multimek Pro Software Reference Manual
- ------------------------------------------------------------------------------------------------
147225        Multimek 96 Tutorial Manual
- ------------------------------------------------------------------------------------------------
147260        P20 Tip Box, Aluminum Reusable - Does not include tips.
- ------------------------------------------------------------------------------------------------
147261        P20 Tip Box, Lightweight Reusable - Does not include tips.
- ------------------------------------------------------------------------------------------------
147262        P20 Tip De-Nester
              For easily de-nesting P20 tips into a reusable tip box for use on the Multimek 96.
- ------------------------------------------------------------------------------------------------
147263        Tip Transfer Tool, P200 - For transferring P200 tips from one tip box to another,
              96 at a time.
- ------------------------------------------------------------------------------------------------
147264        Tip Transfer Tool, P20 - For transferring P20 tips from one tip box to another,
              96 at a time.
- ------------------------------------------------------------------------------------------------
147330        Ball Screw Grease
- ------------------------------------------------------------------------------------------------
147295        Cleanout Needle for Fixed Tip Head
- ------------------------------------------------------------------------------------------------
147292        Wrench Kit
- ------------------------------------------------------------------------------------------------
</TABLE>

24-June-99         Confidential Information of Beckman Coulter, Inc.     Page 21
<PAGE>

Multimek 96 - Channel Pipettor
European Product Description

<TABLE>
<CAPTION>
- ------------------------------------------------------------------------------------------------
Part No.       Description
<S>            <C>
267778         Multimek 96-Channel Pipeftor, 200(MU)L Standard (220\240 VAC)
                                             -----------------
               Includes:
               - 147203 Multimek 96, 200(MU)L Disposable Tip Head, 220 / 240 VAC
               - 147205 (Auto) Tip Load Station
               - 147210 Multimek Pro Software
               - 147220 Five Position Labware Deck

267773         Multimek 96-Channel Pipettor, 200(MU)L Robotic (220 / 240 VAC
                                             ----------------
               Includes:
               - 147208 Multimek 96, 200(MU)L Disposable Tip Head, 220 / 240 VAC
               - 147205 (Auto) Tip Load Station
               - 147210 Multimek Pro Software
               - 147220 Five Position Labware Deck

267780         Multimek 96-Channel Pipeftor, 50(MU)L Standard (220 240 VAC)
                                             ----------------
               includes:
               - 147204 Multimek 96, 50(MU)L Disposable Tip Head, 220 / 240 VAC
               - 147205 (Auto) Tip Load Station
               - 147210 Multimek Pro Software
               - 147220 Five Position Labware Deck

267774         Multimek 96-Channel Pipeftor, 50(MU)L Robotic (220 240 VAC
                                             ---------------
               Includes:
               - 147209 Multmek 96, 50(MU)L Disposable Tip Head, 220 / 240 VAC
               - 147205 (Auto) Tip Load Station
               - 147210 Multimek Pro Software
               - 147220 Five Position Labware Deck
</TABLE>

24-June-99         Confidential Information of Beckman Coulter, Inc.     Page 22
<PAGE>

Multimek 96 - Channel Pipeftor
European Product Description

<TABLE>
<CAPTION>
- ------------------------------------------------------------------------------------------------
Part No.        Description
<S>             <C>
147203          Multimek 96-Channel Pipettor, 2OO(MU)L Standard (220 / 240 VAC
                includes:
                - 147230 200(MU)L Disposable Tip Head, volume range 5 - 2OOpI
                - 147205 (Auto)Tip Load Stabon

147208          Multimek 96-Channel Pipettor, 200(MU)L Robotic (220 240 VAC
                includes:
                - Multimek 96
                - 147299 Light curtain kit ( includes tip box holder, standoffs, screws,
                serial port)
                - 147230 200(MU)L Disposable Tip Head, volume range 5 - 200(MU)L
                - 147205 (Auto)Tip Load Station

147204          Multimek 96-Channel Pipettor, 50(MU)L Standard (220 240 VAC
                includes:
                - 147231 20(MU)L Disposable Tip Head, volume range 1 - 20(MU)L
                - 147205 (Auto)Tip Load Station

147209          Multimek 96-Channel Pipettor, 50(MU)L Robotic (220 240 VAC)
                Includes:
                - Multimek 96
                - 147299 Light curtain kit ( includes tip box holder, standoffs, screws,
                serial port)

                - 147231 20(MU)L Disposable Tip Head, volume range 5 - 200(MU)L
                - 147205 (Auto)Tip Load Station

147210          Multimek Pro Software
                Software for programming and running pipetting methods.

147220          Multimek 96 Labware Deck, Five Position Position #5 open.  For use on
                disposable tip instruments without Up wash systems.

147221          Multimek 96 Labware Deck, Four Position Positions #5 and #6 open.  For use on
                disposable tip instruments with tip wash systems.
</TABLE>

24-June-99         Confidential Information of Beckman Coulter, Inc.     Page 23
<PAGE>

Multimek 96 - Channel Pipettor
European Product Description

<TABLE>
<CAPTION>
- ------------------------------------------------------------------------------------------------
Part No.        Description
<S>             <C>
147230          200(MU)L Disposable Tip Dispense Head including:
                147 240 Deck Standoff Kit, Short

148103          50(MU)L Disposable Tip Dispense Head Conversion Kit

148014          Disposable Tip Wash System
                Includes wash station, wash pump, supply tank, and drain/waste tank.
                Uses position #6 on Multimek deck.

                Multimek(TM) Circulating Reservoir
                European Product Description

148010          Multimek Circulating Reservoir Kit
                INCLUDES: Circulating pump and two pump heads, 1.lL supply bottle (148028),
                delivery cap (148030), 96-well reservoir for Multimek work surface, Tygon and
                PharMed tubing and manual.

                Multimek Circulating Reservoir, System
                Components

148028          1.1 L Reservoir Bottle

148029          5.0 L Reservoir Bottle

148030          Reservoir Delivery Cap

148031          Tubing/Fitting Replacement Kit, Tygon

148032          Tubing/Fitting Replacement Kit, PharMed

148225          Multimek Teflon Circulation Reservoir

148033          Multimek Teflon Reservoir, Stand-Alone
</TABLE>

24-June-99         Confidential Information of Beckman Coulter, Inc.     Page 24
<PAGE>

<TABLE>
<CAPTION>
- --------------------------------------------------------------------------------

Part No.        Description

Multimek(TM) 96 Tips
European Product Description
<S>             <C>
                Multimek(TM)
148005          200 (MU)L Tips, Type 2, Nonsterile (Case of 10 Racks) For use on
                200 (MU)L Disposable Tip Dispense Head

267663          200 (MU)L Tips, Type 2, Nonsterile (Pallet of 125 Cases) For use
                on 200 p(MU)L Disposable Tip Dispense Head

148004          200 (MU)L l Tips, Type 2, Sterile (Case of 10 Racks) For use on
                200 (MU)L Disposable Tip Dispense Head

267662          200 (MU)L Tips, Type 2, Sterile (Pallet of 125 Cases) For use on
                200 (MU)L Disposable Tip Dispense Head

148003          50 (MU)L Tips, Type 2, Nonsterile (Case of 10 Racks) For use on
                50 (MU)L Disposable Tip Dispense Head

267661          50 (MU)L Tips, Type 2, Nonsterile (Pallet of 125 Cases) For use
                on 50 (MU)L Disposable Tip Dispense Head

148002          50 (MU)L Tips, Type 2, Sterile (Case of 10 Racks) For use on 50
                (MU)L Disposable Tip Dispense Head

267660          50 (MU)L Tips, Type 2, Sterile (Pallet of 125 Cases) For use on
                50 (MU)L Disposable Tip Dispense Head

                Multimek(TM) Tip Conversion Kits
                European Product Description

267633          Multimek P20 to P50/P200 Type 1 Tip Conversion Kit
                Includes:
                147293: Type 1 Tip Hardware Kit
                147240: Short Standoffs
                147337: Push Tab

267634          Multimek P20 to P50 Type 2 Tip Conversion Kit Includes:
                148097: P50 Type 2 Tip Carrier
                147337: Push Tab

267635          Multimek P20 to P200 Type 2 Tip Conversion Kit Includes:
                147243: P200 Type 2 Tip Hardware Kit
                147240: Short Standoffs
                147337: Push Tab
</TABLE>

24-June-99       Confidential Information of Beckman Coulter, Inc.       Page 25
<PAGE>

<TABLE>
<S>             <C>
267636          Multimek P50/P200 Type 2 to P20 Tip Conversion Kit
                Includes:
                147205: Type 1 Tip Carrier
                147293: Type 1 Tip Hardware Kit
                147241: Tall Standoffs
                147260: P20 Tip Box, Aluminum

267637          Multimek Type 2 to P50/P200 Type I Tip Conversion Kit
                Includes:
                147205: Type 1 Tip Carrier
                147293: Type 1 Tip Hardware Kit

267638          Multimek P50/P200 Type I to P20 Tip Conversion Kit
                Includes:
                147241: Tall Standoffs
                147260: P20 Tip Box, Aluminum
</TABLE>


- --------------------------------------------------------------------------------
<TABLE>
<CAPTION>
Part No.        Description
<S>             <C>
                Multimek(TM) 96 Parts and Supplies
                European Product Description

147299          Multimek 96 Light Curtain Kit
                Components for utilizing a Multimek 96 on Beckman Coulter/SAGIAN integrated
                systems.

147035          MultiPette Safety Upgrade Kit, Shield

148036          MultiPette Safety Upgrade Kit, Light Curtain

148094          Automatic Tip Loading Station (For 200 (MU)L Type 2 tips only)

147205          Automatic Tip Loading Station (For 20 (MU)L Type 1 UPS)

147097          Automatic Tip Loading Station (For 50 (MU)L Type 2 tips)

147240          Deck Standoff Kit
                For use with 200 (MU)L Disposable Tip Head

147241          Deck Standoff Kit
                For use with 20 (MU)L Disposable Tip Head
</TABLE>

24-June-99       Confidential Information of Beckman Coulter, Inc.       Page 26
<PAGE>

<TABLE>
<S>             <C>
147216          Multimek 96 Installation and Operations Binder Includes
                Installation and Maintenance Manual, Basic Training Manual and
                Tutorial Manual

147211          Multimek 96 Installation and Maintenance Manual

147212          Multimek Pro Software Reference Manual

147225          Multimek 96 Tutorial Manual

147260          P20 Tip Box, Aluminum, reusable

147261          P20 Tip Box, lightweight, reusable

147262          P20 Tip De-Nester

147263          P200 Tip Transfer Tool

147264          P20 Tip Transfer Tool

147330          Ball Screw Grease

147295          Cleanout Needle for Fixed Tip Head

147292          Wrench Kit

<CAPTION>
Part No.        Description
<S>             <C>
                Multimek(TM) 96 Stacker Carousel
                European Product Description

148364          Single Stacker Carousel System for Multimek 96
                Includes Carousel for mounting on left side of Multimek 96 Pipettor and
                Multimek Stacker Carousel Software.  Labware Deck and Stacker's ordered
                separately.

267664          Double Stacker Carousel System for Multimek 96
                Includes Carousels for mounting on left and right sides of Multimek 96
                Pipettor, Multimek Stacker Carousel Software and two-position Labware Deck.
                Stackers ordered separately.

148246          Stacker 20

148247          Stacker 10

148257          Stacker HD (capacity 45 Microplates
</TABLE>

24-June-99       Confidential Information of Beckman Coulter, Inc.       Page 27
<PAGE>

<TABLE>
<S>             <C>
148104          Labware Deck, Two-Position (1,2)

148105          Labware Deck, Three-Position (1,2,4)

148106          Labware Deck, Four-Position (1,2,4,6)

148258          Bar Code Reader for Multimek
</TABLE>

- --------------------------------------------------------------------------------

<TABLE>
<CAPTION>
Part No.        Description

Multimek Stacker Carousel Parts
European Product Description
<S>             <C>
148366          Multimek Stacker Carousel Software

148404          Multimek Stacker Carousel Kit, Left Side
                INCLUDES: Left Multimek Stacker Carousel Base, Control Pendant
                with Cable (148240), Cable (148244), Wrenches (148353 and
                148354), Bubble Level (148270) and Manual (148403).

148365          Multimek Stacker Carousel Kit, Right Side
                INCLUDES: Right Multimek Stacker Carousel Base, Control Pendant
                with Cable (148240), Cable (148244), and Serial Card for
                Controller.

148240          Control Pendant with Cable

148241          Pendant Cable

148244          Communications Cable - Carousel to Controller

148270          Bubble Level

148353          Allen Wrench, 3/16 inch

148354          Allen Wrench, 5/16 inch

148403          Multimek Stacker Carousel Users Manual
</TABLE>

24-June-99        Confidential Information of Beckman Coulter, Inc.      Page 28
<PAGE>

                     EXHIBIT B - SEQUENOM PRICING SCHEDULE

1    QUALIFICATION


     Sequenom will be eligible for discounts for products purchased from BCI as
     described In Exhibit A under the following Pricing Schedule A): Multimek
     Workstation.

     Sequenom will be eligible for discounts on Mufflmek Tools and Accessories
     for products purchased from BCI under the following Pricing Schedule 0):
     Muftimak Workstation Tools and Accessodes.



2    DISCOUNT LEVEL

Pricing Schedule A) Multimek Workstation
                                      ***
                                      ***
                                      ***
                                      ***


                                      ***
                                      ***
                                      ***
                                      ***

Pricing. Schedule B) Multimek Tools and Accessories
BCI will provide Sequenom a    ***    on all Multimek tools and/or accessories
ordered on a standalone basis.





          *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

24-June-99       Confidential Information of Beckman Coulter, Inc.       Page 29
<PAGE>

                  Exhibit C - Joint Research and Development



1)   BCI and Sequenom will collaborate to develop specifications, development
     plans and schedules for                   ***
                                               ***

2)                                       ***
                                         ***
                                         ***
                                         ***
                                         ***

3)                                             ***
                                               ***
                                               ***
                                               ***
                                               ***

4)                                             ***
                                               ***
                                               ***
                                               ***
                                               ***

5)                                             ***
                                               ***
                                               ***
                                               ***
                                               ***





          *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

24-June-99       Confidential Information of Beckman Coulter, Inc.       Page 30
<PAGE>

                       Exhibit D- Product Specifications


                                         ***
                                         ***
                                         ***
                                         ***
                                         ***
                                         ***

                                         ***
                                         ***
                                         ***
                                         ***
                                         ***
                                         ***



          *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

24-June-99       Confidential Information of Beckman Coulter, Inc.       Page 31
<PAGE>

                         Exhibit "E" Spare Parts List


<TABLE>
<CAPTION>
PART NUMBER           Beckman                      Description                         Quan     U/M
                      Part #
- -------------------------------------------------------------------------------------------------------
MANUALS
- -------------------------------------------------------------------------------------------------------
<C>                  <C>          <S>                                                  <C>      <C>
100-00-00232         147211       MULTIMEK 96 INSTALLATION AND                         1        ea
                                  MAINTENANCE MANUAL
100-36-00202         147222       MULTIMEK PRE-INSTALLATION MANUAL                     1        ea
100-00-00262         148050       MULTIMEK MANUALS                                     1        ea
                                  (includes: Software ref, Basic Training and
                                  Tutorial Manuals)

MULTIMEK
- --------

075-05-00009         147310       LITTLE STAR CONTROLLER                               1        ea
085-05-00067         147311       LITTLE STAR REMOTE KEYPAD                            1        ea
085-05-00068         147341       LITTLE STAR REMOTE DISPLAY                           1        ea
075-05-00010         147312       IMS CONTROLLER                                       1        ea
118-15-00006         147313       FUSE - 5 AMP                                         1        ea
118-15-00007         147314       FUSE - 7 AMP                                         1        ea
074-00-00019         148101       STEPPER MOTOR & ENCODER                              1        ea
066-15-00013         147318       OPTICAL SENSOR / 90 DEGREE                           1        ea
066-15-00014         147319       OPTICAL SENSOR / FLAT                                1        ea
069-15-00055         147320       RS232 CABLE                                          1        ea
069-15-00056         147321       14 CONDUCTOR RIBBON CABLE                            1        ea
069-15-00057         147322       10 CONDUCTOR FLEX FILM                               1        ea
069-15-00058         147323       16 CONDUCTOR FLEX FILM                               1        ea
090-05-00077         147324       BALL NUT                                             1        ea
071-05-00008         147325       SMALL TIMING BELT                                    1        ea
071-05-00009         147326       LARGE TIMING BELT                                    1        ea
085-05-00070         147328       AUTO TIP LOAD CARRIER SIDE ARM                       1        ea
                                  (RIGHT ARM)
085-05-00071         147329       AUTO TIP LOAD CARRIER SIDE ARM                       1        ea
                                  (LEFT ARM)
097-05-00013         147330       BALL SCREW GREASE                                    1        ea
113-05-00007         147331       TOUCH UP PAINT                                       1        ea
073-05-00011         147332       DISPENSE HEAD COVER                                  1        ea
090-05-00078         147333       Z-AXIS LEAD SCREW                                    1        ea
085-05-00072         147334       Z-AXIS FLAG                                          1        ea
085-05-00073         147335       X-AXIS HOME FLAG                                     1        ea
085-05-00074         147337       UNIVERSAL TIP BOX PUSH TAB                           1        ea
064-00-00017                      LARGE BIMBA AIR CYLINDER                             1        ea
090-00-00133                      AIR CYLINDER SHAFT SPACER                            1        ea
114-00-00051                      MULTIMEK CRATE                                       1        ea
</TABLE>

24-June-99       Confidential Information of Beckman Coulter, Inc.       Page 32

<PAGE>

                                                                   EXHIBIT 10.36

                             PUBLIC HEALTH SERVICE
                COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT

This Cooperative Research and Development Agreement, hereinafter referred to as
the "CRADA," consists of this Cover Page, an attached Agreement, and various
Appendices referenced in the Agreement.  This Cover Page serves to identify the
Parties to this CRADA:

     (1) the following Bureau(s), Institute(s), Center(s) or Division(s) of the
National Institutes of Health ("NIH"), the Food and Drug Administration ("FDA"),
and the Centers for Disease Control and Prevention ("CDC"):  Inherited Disease
Branch, National Human Genome Research Institute (NHGRI), hereinafter singly or
collectively referred to as the Public Health Service ("PHS"); and

     (2) Sequenom, Inc, which has offices at I1 555 Sorrento Valley Road, San
Diego, CA 92121-0345, hereinafter referred to as the 'Collaborator."


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<PAGE>

                COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT

Article 1. Introduction

This Cooperative Research and Development Agreement (CRADA) between PHS and the
Collaborator will be effective when signed by all Parties.  The research and
development activities which will be undertaken by each of the Parties in the
course of this CRADA are detailed in the Research Plan (RP) which is attached as
Appendix A. The funding and staffing commitments of the Parties are set forth in
Appendix B. Any exceptions or changes to the CRADA are set forth in Appendix C.
This CRADA is made under the authority of the Federal Technology Transfer Act,
15 U.S.C. (S)37 10a and is governed by its terms.

Article 2. Definitions

As used in this CRADA, the following terms shall have the indicated meanings:

2.1  "Affiliate" means any corporation or other business entity controlled by,
     controlling, or under common control with Collaborator.  For this purpose,
     "control" means direct or indirect beneficial ownership of at least fifty
     (50) percent of the voting stock or at least fifty (50) percent interest in
     the income of such corporation or other business.

2.2  "Cooperative Research and Development Agreement" or "CRADA" means this
     Agreement entered into by PHS pursuant to the Federal Technology Transfer
     Act of 1986, as amended, 15 U.S.C. 37 10a et. seq. and Executive Order
                                               --------
     12591 of October 10, 1987.

2.3  "Government" means the Government of the United States as represented
     through the PHS agency that is a Party to this agreement.

2.4  "IP" means intellectual property.

2.5  "Invention" means any invention or discovery which is or may be patentable
     or otherwise protected under title 35, United States Code, or any novel
     variety or plant which is or may be protectable under the Plant Variety
     Protection Act (7 U.S.C. 2321 et. seq.).
                                   --------

2.6  "Principal Investigator(s)" or "PIs" means the persons designated
     respectively by the Parties to this CRADA who will be responsible for the
     scientific and technical conduct of the RP.

2.7  "Proprietary/Confidential Information" means confidential scientific,
     business, or financial information provided that such information does not
     include:

     2.7.1  information that is publicly known or available from other sources
            who are not under a confidentiality obligation to the source of the
            information;

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     2.7.2  information which has been made available by its owners to others
            without a confidentiality obligation;

     2.7.3  information which is already known by or available to the receiving
            Party without a confidentiality obligation; or

     2.7.4  information which relates to potential hazards or cautionary
            warnings associated with the production, handling or use of the
            subject matter of the Research Plan of this CRADA.

2.8  "Research Materials" means all tangible materials other than Subject Data
     first produced in the performance of this CRADA.

2.9  "Research Plan" or "RP" means the statement in Appendix A of the respective
     research and development commitments of the Parties to this CRADA.

2.10 "Subject Invention" means any Invention of the Parties, conceived or first
     actually reduced to practice in the performance of the Research Plan of
     this CRADA.

2.11 "Subject Data" means all recorded information first produced in the
     performance of this CRADA by the Parties.

Article 3. Cooperative Research

3.1  Principal Investigators.  PHS research work under this CRADA will be
     performed by the PHS laboratory identified in the RP, and the PHS Principal
     Investigator (PI) designated in the RP will be responsible for the
     scientific and technical conduct of this project on behalf of PHS.  Also
     designated in the RP is the Collaborator PI who will be responsible for the
     scientific and technical conduct of this project on behalf of the
     Collaborator.

3.2  Research Plan Change.  The RP may be modified by mutual written consent of
     the Principal Investigators.  Substantial changes in the scope of the RP
     will be treated as amendments under Article 13.6.

Article 4. Reports

4.1  Interim Reports.  The Parties shall exchange formal written interim
     progress reports on a schedule agreed to by the PIs, but at least within
     twelve (12) months after this CRADA becomes effective and at least within
     every twelve (12) months thereafter. Such reports shall set forth the
     technical progress made, identifying such problems as may have been
     encountered and establishing goals and objectives requiring further effort,
     any modifications to the Research Plan pursuant to Article 3.2, and all
     CRADA-related patent applications filed.

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4.2  Final Reports.  The Parties shall exchange final reports of their results
     within four (4) months after completing the projects described in the RP or
     after the expiration or termination of this CRADA.

Article 5. Financial and Staffing Obligations

5.1  PHS and Collaborator Contributions.  The contributions of the Parties,
     including payment schedules, if applicable, are set forth in Appendix B.
     PHS shall not be obligated to perform any of the research specified herein
     or to take any other action required by this CRADA if the funding is not
     provided as set forth in Appendix B. PHS shall return excess funds to the
     Collaborator when it sends its final fiscal report pursuant to Article 5.2,
     except for staffing support pursuant to Article 10.3. Collaborator
     acknowledges that the U.S. Government will have the authority to retain and
     expend any excess funds for up to one (1) year subsequent to the expiration
     or termination of the CRADA to cover any costs incurred during the term of
     the CRADA.in undertaking the work set forth in the RP.

5.2  Accounting Records.  PHS shall maintain separate and distinct current
     accounts, records, and other evidence supporting all its obligations under
     this CRADA, and shall provide the Collaborator a final fiscal report
     pursuant to Article 4.2.

5.3  Capital Equipment.  Equipment purchased by PHS with funds provided by the
     Collaborator shall be the property of PHS.  All capital equipment provided
     under this CRADA by one party for the use of another Party remains the
     property of the providing Party unless other disposition is mutually agreed
     upon by in writing by the Parties.  If title to this equipment remains with
     the providing Party, that Party is responsible for maintenance of the
     equipment and the costs of its transportation to and from the site where it
     will be used.

Article 6. Patent Applications

6.1  Reporting.  The Parties shall promptly report to each other in writing each
     Subject Invention and any patent applications filed thereon resulting from
     the research conducted under this CRADA that is reported to them by their
     respective employees.  Each Party shall report all Subject Inventions to
     the other Party in sufficient detail to determine inventorship.  Such
     reports shall be treated as Proprietary/Confidential Information in
     accordance with Article 8.4.

6.2  Filing of Patent Applications.  Each party shall be responsible for filing
     patent or other EP applications in a timely manner and at its own expense.
     The Parties will consult and mutually determine a filing strategy for
     jointly owned subject inventions.

6.3  Patent Expenses.  The expenses attendant to the filing of patent or other
     IP applications generally shall be paid by the Party filing such
     application.  If an exclusive license to any Subject Invention is granted
     to the Collaborator, the Collaborator shall be responsible for all past and
     future out-of-pocket expenses in connection with the preparation, filing,

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     prosecution and maintenance of any applications claiming such exclusively
     licensed inventions and any patents or other IP grants that may issue on
     such applications.  The Collaborator may waive its exclusive license rights
     on any application, patent or other IP grant at any time, and incur no
     subsequent compensation obligation for that application, patent or EP
     grant.

6.4  Prosecution of Intellectual Property Applications.  Within one month of
     -------------------------------------------------
     receipt or filing, each Party shall provide the other Party with copies of
     the applications and all documents received from or filed with the relevant
     patent or other EP office in connection with the prosecution of such
     applications.  Each Party shall also provide the other Party with the power
     to inspect and make copies of all documents retained in the patent or other
     IP application files by the applicable patent or other EP office.  Where
     licensing is contemplated by Collaborator, the Parties agree to consult
     with each other with respect to the prosecution of applications for PHS
     Subject Inventions described in Article 6.3 and joint Subject Inventions
     described in Article 6.4. If the Collaborator elects to file and prosecute
     EP applications on joint Subject Inventions pursuant to Article 6.4, PHS
     will be granted an associate power of attorney (or its equivalent) on such
     EP applications.

Article 7. Licensing

7.1  Option for Commercialization License.  With respect to Government IP rights
     to any Subject Invention not made solely by the Collaborator's employees
     for which a patent or other E? application is filed, PHS hereby grants to
     the Collaborator an exclusive option to elect an exclusive or nonexclusive
     commercialization license, which is substantially in the form of the
     appropriate model PHS license agreement.  This option does not apply to
     Subject Inventions conceived prior to the effective date of this CRADA that
     are reduced to practice under this CRADA, if prior to that reduction to
     practice, PHS has filed a patent application on the invention and has
     licensed it or offered to license it to a third party.  The terms of the
     license will fairly reflect the nature of the invention, the relative
     contributions of the Parties to the invention and the CRADA, the risks
     incurred by the Collaborator and the costs of subsequent research and
     development needed to bring the invention to the marketplace.  The field of
     use of the license will be commensurate with the scope of the RP.

7.2  Exercise of License Option.  The option of Article 7.1 must be exercised by
     written notice mailed within three (3) months after either (i) Collaborator
     receives written notice from PHS that the patent or other EP application
     has been filed; or (ii) the date Collaborator files such EP application.
     Exercise of this option by the Collaborator initiates a negotiation period
     that expires nine (9) months after the exercise of the option.  If the last
     proposal by the Collaborator has not been responded to in writing by PHS
     within this nine (9) month period, the negotiation period shall be extended
     to expire one (1) month after PHS so responds, during which month the
     Collaborator may accept in writing the final license proposal of PHS.  In
     the absence of such acceptance, or an extension of the time limits by PHS,
     PHS will be free to license such IP rights to others.

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     In the event that the Collaborator elects the option for an exclusive
     license, but no such license is executed during the negotiation period, PHS
     agrees not to make an offer for an exclusive license on more favorable
     terms to a third party for a period of six (6) months without first
     offering Collaborator those more favorable terms. These times may be
     extended at the sole discretion of PHS upon good cause shown in writing by
     the Collaborator.

7.3  License for PHS Employee Inventions and Joint Inventions.  Pursuant to 15
     U.S.C. (S) 37 10a(b)(1)(A), for Subject Inventions made under this CRADA by
     a PHS employee(s) or jointly by such employee(s) and employees of the
     Collaborator pursuant to Articles 6.3 and 6.4 and licensed pursuant to the
     option of Article 7.1, the Collaborator grants to the Government a
     nonexclusive, nontransferable, irrevocable, paid-up license to practice the
     invention or have the invention practiced throughout the world by or on
     behalf of the Government.  In the exercise of such license, the Government
     shall not publicly disclose trade secrets or commercial or financial
     information that is privileged or confidential within the meaning of 5
     U.S.C. 552(b)(4) or which would be considered as such if it had been
     obtained from a non-Federal party.

7.4  License in Collaborator Inventions.  Pursuant to 15 U.S.C. (S) 3710a(b)(2),
     for inventions made solely by Collaborator employees under this CRADA
     pursuant to Article 6.2, the Collaborator grants to the Government a
     nonexclusive, nontransferable, irrevocable, paid-up license to practice the
     invention or have the invention practiced throughout the world by or on
     behalf of the Government for research or other Government purposes.

7.5  Third Party License.  Pursuant to 15 U.S.C. (S) 3710a(b)(1)(B), if PHS
     grants an exclusive license to a Subject Invention made wholly by PHS
     employees or jointly with a Collaborator under this CRADA, pursuant to
     Articles 6.3 and 6.4, the Government shall retain the right to require the
     Collaborator to grant to a responsible applicant a nonexclusive, partially
     exclusive, or exclusive sublicense to use the invention in Collaborator's
     licensed field of use on terms that are reasonable under the circumstances;
     or if the Collaborator fails to grant such a license, to grant the license
     itself.  The exercise of such rights by the Government shall only be in
     exceptional circumstances and only if the Government determines (i) the
     action is necessary to meet health or safety needs that are not reasonably
     satisfied by Collaborator, (ii) the action is necessary to meet
     requirements for public use specified by Federal regulations, and such
     requirements are not reasonably satisfied by the Collaborator; or (iii) the
     Collaborator has failed to comply with an agreement containing provisions
     described in 15 U.S.C. 3710a(c)(4)(B).  The determination made by the
     Government under this Article is subject to administrative appeal and
     judicial review under 35 U.S.C. 203(2).

7.6  Joint Inventions Not Exclusively Licensed.  In the event that the
     Collaborator does not acquire an exclusive commercialization license to EP
     rights in all fields in joint Subject Inventions described in Article 6.4,
     then each Party shall have the right to use the joint

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     Subject Invention and to license its use to others in all fields not
     exclusively licensed to Collaborator. The Parties may agree to a joint
     licensing approach for such EP rights.

Article 8. Proprietary Rights and Publication

8.1  Right of Access.  PHS and the Collaborator agree to exchange all Subject
     Data produced in the course of research under this CRADA.  Research
     Materials will be shared equally by the Parties to the CRADA unless other
     disposition is agreed to by the Parties.

All Parties to this CRADA will be free to utilize Subject Data and Research
Materials for their own purposes, consistent with their obligations under this
CRADA.

8.2  Ownership of Subject Data and Research Materials.  Subject to the sharing
     requirements of Paragraph 8.1 and the regulatory filing requirements of
     Paragraph 8.3, the producing Party will retain ownership of and title to
     all Subject Inventions, all Subject Data and all Research Materials
     produced solely by their investigators.  Jointly developed Subject
     Inventions, Subject Data and Research Materials will be jointly owned.

8.3  Dissemination of Subject Data and Research Materials.  To the extent
     permitted by law, the Collaborator and PHS agree to use reasonable efforts
     to keep Subject Data and Research Materials confidential until published or
     until corresponding patent applications are filed.  Any information that
     would identify human subjects of research or patients will always be
     maintained confidentially.  To the extent permitted by law, the
     Collaborator shall have the exclusive right to use any and all CRADA
     Subject Data in and for any regulatory filing by or on behalf of
     Collaborator, except that PHS shall have the exclusive right to use Subject
     Data for that purpose, and authorize others to do so, if the CRADA is
     terminated or if Collaborator abandons its commercialization efforts.
     Collaborator acknowledges the basic research mission of the PHS, and agrees
     that after publication, PHS may make unpatented research materials arising
     out of this CRADA available to third parties for further research.

8.4  Proprietary/Confidential Information.  Each Party agrees to limit its
     disclosure of Proprietary/Confidential Information to the amount necessary
     to carry out the Research Plan of this CRADA, and shall place a
     confidentiality notice on all such information.  Confidential oral
     communications shall be reduced to writing within 30 days by the disclosing
     Party. Each Party receiving Proprietary/Confidential Information agrees
     that any information so designated shall be used by it only for the
     purposes described in the attached Research Plan. Any Party may object to
     the designation of information as Proprietary/Confidential Information by
     another Party. Subject Data and Research Materials developed solely by the
     Collaborator may be designated as Proprietary/Confidential Information when
     they are wholly separable from the Subject Data and Research Materials
     developed jointly with PHS investigators, and advance designation of such
     data and material categories is set forth in the RP. 'Me exchange of other
     confidential information, e.g., patient-identifying data, should be
     similarly limited and treated. Jointly developed Subject Data and Research
     Material derived from the

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     Research Plan may be disclosed by Collaborator to a third party under a
     confidentiality agreement for the purpose of possible sublicensing pursuant
     to the Licensing Agreement and subject to Article 8.7.

8.5  Protection of Proprietary/Confidential Information.
     Proprietary/Confidential Information shall not be disclosed, copied,
     reproduced or otherwise made available to any other person or entity
     without the consent of the owning Party except as required under court
     order or the Freedom of information Act (5 U.S.C. 1 552). Each Party agrees
     to use its best efforts to maintain the confidentiality of
     Proprietary/Confidential Information. Each Party agrees that the other
     Party is not liable for the disclosure of Proprietary/Confidential
     Information which, after notice to and consultation with the concerned
     Party, the other Party in possession of the Proprietary/Confidential
     Information determines may not be lawfully withheld, provided the concerned
     Party has been given an opportunity to seek a court order to enjoin
     disclosure.

8.6  Duration of Confidentiality Obligation.  The obligation to maintain the
     confidentiality of Proprietary/Confidential Information shall expire at the
     earlier of the date when the information is no longer Proprietary
     Information as defined in Article 2.7 or three (3) years after the
     expiration or termination date of this CRADA.  The Collaborator may request
     an extension to this term when necessary to protect
     Proprietary/Confidential Information relating to products not yet
     commercialized.

8.7  Publication.  The Parties are encouraged to make publicly available the
     results of their research.  Before either Party submits a paper or abstract
     for publication or otherwise intends to publicly disclose information about
     a Subject Invention, Subject Data or Research Materials, the other Party
     shall be provided thirty (30) days to review the proposed publication or
     disclosure to assure that Proprietary/Confidential Information is
     protected.  The publication or other disclosure shall be delayed for up to
     thirty (30) additional days upon written request by any Party as necessary
     to preserve U.S. or foreign patent or other IP rights.

Article 9. Representations and Warranties

9.1  Representations and Warranties of PHS.  PHS hereby represents and warrants
     to the Collaborator that the official signing this CRADA has authority to
     do so.

9.2  Representations and Warranties of the Collaborator.

     (a)  The Collaborator hereby represents and warrants to PHS that the
     Collaborator has the requisite power and authority to enter into this CRADA
     and to perform according to its terms, and that the Collaborator's official
     signing this CRADA has authority to do so.  The Collaborator further
     represents that it is financially able to satisfy any funding commitments
     made in Appendix B.

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     (b)  The Collaborator certifies that the statements herein are true,
     complete, and accurate to the best of its knowledge.  The Collaborator is
     aware that any false, fictitious, or fraudulent statements or claims may
     subject it to criminal, civil, or administrative penalties.

Article 10.  Termination

10.1 Termination By Mutual Consent. PHS and the Collaborator may terminate this
     CRADA, or portions thereof, at any time by mutual written consent. In such
     event the Parties shall specify the disposition of all property,
     inventions, patent or other EP applications and other results of work
     accomplished or in progress, arising from or performed under this CRADA,
     all in accordance with the rights granted to the Parties under the terms of
     this Agreement.

10.2 Unilateral Termination. Either PHS or the Collaborator may unilaterally
     terminate this entire CRADA at any time by giving written notice at least
     thirty (30) days prior to the desired termination date, and any rights
     accrued in property, patents or other IP rights shall be disposed of as
     provided in paragraph 10.1.

10.3 Staffing. If this CRADA is mutually or unilaterally terminated prior to its
     expiration, funds will nevertheless remain available to PHS for continuing
     any staffing commitment made by the Collaborator pursuant to Article 5.1
     above and Appendix B, if applicable, for a period of six (6) months after
     such termination. If there are insufficient funds to cover this expense,
     the Collaborator agrees to pay the difference.

10.4 New Commitments. No Party shall make new commitments related to this CRADA
     after a mutual termination or notice of a unilateral termination and shall,
     to the extent feasible, cancel all outstanding commitments and contracts by
     the termination date.

10.5 Termination Costs. Concurrently with the exchange of final reports pursuant
     to Articles 4.2 and 5.2, PHS shall submit to the Collaborator for payment a
     statement of all costs incurred prior to the date of termination and for
     all reasonable termination costs including the cost of returning
     Collaborator property or removal of abandoned property, for which
     Collaborator shall be responsible.

Article 11.  Disputes

11.1 Settlement. Any dispute arising under this CRADA which is not disposed of
     by agreement of the Principal Investigators shall be submitted jointly to
     the signatories of this CRADA. If the signatories are unable to jointly
     resolve the dispute within thirty (30) days after notification thereof, the
     Assistant Secretary for Health (or his/her designee or successor) shall
     propose a resolution. Nothing in this Article shall prevent any Party from
     pursuing any additional administrative remedies that may be available and,
     after exhaustion of such administrative remedies, pursuing all available
     judicial remedies.

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11.2 Continuation of Work. Pending the resolution of any dispute or claim
     pursuant to this Article, the Parties agree that performance of all
     obligations shall be pursued diligently in accordance with the direction of
     the PHS signatory.

Article 12.  Liability

12.1 Property. The U.S. Government shall not be responsible for damages to any
     Collaborator property provided to PHS, where Collaborator retains title to
     the property, or any property acquired by Collaborator for its own use
     pursuant to this CRADA.

12.2 NO WARRANTIES. EXCEPT AS SPECIFICALLY STATED IN ARTICLE 9, THE PARTIES MAKE
     NO EXPRESS OR IMPLIED WARRANTY AS TO ANY MATTER WHATSOEVER, INCLUDING THE
     CONDITIONS OF THE RESEARCH OR ANY INVENTION OR PRODUCT, WHETHER TANGIBLE OR
     INTANGIBLE, MADE, OR DEVELOPED UNDER THIS CRADA, OR THE OWNERSHIP,
     MERCHANTABILITY, OR FITNESS FOR A PARTICULAR PURPOSE OF THE RESEARCH OR ANY
     INVENTION OR PRODUCT.

12.3 Indemnification. The Collaborator agrees to hold the U.S. Government
     harmless and to indemnify the Government for all liabilities, demands,
     damages, expenses and losses arising out of the use by die Collaborator for
     any purpose of the Subject Data, Research Materials and/or Subject
     Inventions produced in whole or part by PHS employees under this CRADA,
     unless due to the negligence or willful misconduct of PHS, its employees,
     or agents. The Collaborator shall be liable for any claims or damages it
     incurs in connection with this CRADA. PHS has no authority to indemnify the
     Collaborator.

12.4 Force Majeure. Neither Party shall be liable for any unforeseeable event
     beyond its reasonable control not caused by the fault or negligence of such
     Party, which causes such Party to be unable to perform its obligations
     under this CRADA, and which it has been unable to overcome by the exercise
     of due diligence. In the event of the occurrence of such a force majeure
     event, the Party unable to perform shall promptly notify the other Party.
     It shall further use its best efforts to resume performance as quickly as
     possible and shall suspend performance only for such period of time as is
     necessary as a result of the force majeure event.

Article 13.  Miscellaneous

13.1 Governing Law. The construction, validity, performance and effect of this
     CRADA shall be governed by Federal law, as applied by the Federal Courts in
     the District of Columbia. Federal law and regulations will preempt any
     conflicting or inconsistent provisions in this CRADA.

13.2 Entire Agreement. This CRADA constitutes the entire agreement between the
     Parties concerning the subject matter of this CRADA and supersedes any
     prior understanding or written or oral agreement.

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13.3  Headings. Tides and headings of the articles and subarticles of this CRADA
      arc for convenient reference only, do not form a part of this CRADA, and
      shall in no way affect its interpretation. The PHS component that is the
      Party for all purposes of this CRADA is the Bureau(s), Institute(s),
      Center(s) or Division(s) listed on the Cover Page herein.

13.4  Waivers. None of the provisions of this CRADA shall be considered waived
      by any Party unless such waiver is given in writing to the other Party.
      The failure of a Party to insist upon strict performance of any of the
      terms and conditions hereof, or failure or delay to exercise any rights
      provided herein or by law, shall not be deemed a waiver of any rights of
      any Party.

13.5  Severability. The illegality or invalidity of any provisions of this CRADA
      shall not impair, affect, or invalidate the other provisions of this
      CRADA.

13.6  Amendments. If either Party desires a modification to this CRADA, the
      Parties shall, upon reasonable notice of the proposed modification or
      extension by the Party desiring the change, confer in good faith to
      determine the desirability of such modification or extension. Such
      modification shall not be effective until a written amendment is signed by
      the signatories to this CRADA or by their representatives duly authorized
      to execute such amendment.

13.7  Assignment. Neither this CRADA nor any rights or obligations of any Party
      hereunder shall be assigned or otherwise transferred by either Party
      without the prior written consent of die other Party.

13.8  Notices. All notices pertaining to or required by this CRADA shall be in
      writing and shall be signed by an authorized representative and shall be
      delivered by hand or sent by certified mail, return receipt requested,
      with postage prepaid, to the addresses indicated on the signature page for
      each Party. Notices regarding the exercise of license options shall be
      made pursuant to Article 7.2. Any Party may change such address by notice
      given to the other Party in the manner set forth above.

13.9  Independent Contractors. The relationship of the Parties to this CRADA is
      that of independent contractors and not agents of each other or joint
      venturers or partners. Each Party shall maintain sole and exclusive
      control over its personnel and operations. Collaborator employees who will
      be working at PHS facilities may be asked to sign a Guest Researcher or
      Special Volunteer Agreement appropriately modified in view of the terms of
      this CRADA.

13.10 Use of Name or Endorsements. By entering into this CRADA, PHS does not
      directly or indirectly endorse any product or service provided, or to be
      provided, whether directly or indirectly related to either this CRADA or
      to any patent or other EP license or agreement which implements this CRADA
      by its successors, assignees, or licensees. The Collaborator shall not in
      any way state or imply that this CRADA is an endorsement of any such
      product or service by the U.S. Government or any of its organizational
      units or

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      employees.  Collaborator issued press releases that reference or rely upon
      the work of PHS under this CRADA shall be made available to PHS at least 7
      days prior to publication for review and comment.

13.11 Exceptions to this CRADA. Any exceptions or modifications to this CRADA
      that are agreed to by the Parties prior to their execution of this CRADA
      are set forth in Appendix C.

13.12 Reasonable Consent. Whenever a Party's consent or permission is required
      under this CRADA, such consent or permission shall not be unreasonably
      withheld.

Article 14.  Duration of Agreement

14.1  Duration. It is mutually recognized that the duration of this project
cannot be rigidly defined in advance, and that the contemplated time periods for
various phases of the RP are only good faith guidelines subject to adjustment by
mutual agreement to fit circumstances as the RP proceeds. In no case will the
term of this CRADA extend beyond the term indicated in the RP unless it is
revised in accordance with Article 13.6.

14.2  Survivability. The provisions of Articles 4.2, 5-8, 10.3-10.5, 11.1, 12.2-
12.4, 13.1, 13.10 and 14.2 shall survive the termination of this CRADA.

                       SIGNATURES BEGIN ON THE NEXT PAGE

                                NHGRI-Sequenom
                            PHS CRADA Model 3/15/99
                                 Page 12 of 13
<PAGE>

                             CRADA SIGNATURE PAGE

FOR PHS:


      /s/ Michael M. Gottesman                             9/23/99
- ------------------------------------             --------------------------
Michael M. Gottesman, M.D.                       Date
Deputy Director for Intramural Research
National Institutes of Health


Mailing Address for Notices:

Technology Transfer Office
National Human Genome Research Institute (NHGRI)
National Institutes of Health
45 Center Drive MSC 6320
Building 45, Room 3As43
Bethesda, MD 20892-6320
Tel. (301) 435-0042
Fax (301) 402-9722

FOR COLLABORATOR

      /s/ Hubert Koster                                    9/17/99
- ------------------------------------             --------------------------
Hubert Koster, Ph.D.,                            Date
President and CEO
Sequenom, Inc.


Mailing Address for Notices:

Sequenom, Inc.
11555 Sorrento Valley Road
San Diego, CA 92121-1331
Tel. (619) 359-0345
Fax (619) 350-0344

                                NHGRI-Sequenom
                            PHS CRADA Model 3/15/99
                                 Page 13 of 13
<PAGE>

                                  APPENDIX A

                                 RESEARCH PLAN

TITLE OF CRADA:                             ***
                --------------------------------------------------------------

PHS CO-PRINCIPAL INVESTIGATORS: Robert L. Nussbaum M.D. and Francis S.  Collins,
                                ------------------------------------------------
M.D., Ph.D.
- -----------

his/her Laboratory: Inherited Disease Research Branch (IDRB) and the Genetic and
                    ------------------------------------------------------------
Molecular Biology Branch (GMBB).  National Human Genome Research Institute
- --------------------------------------------------------------------------
(NHGRI),  National Institutes of Health (NIH)
- ---------------------------------------------

COMPANY CO-PRINCIPAL INVESTIGATORS: Daniel P. Little, Ph.D. and Andreas Braun,
                                    ------------------------------------------
Ph.D., M.D., Sequenom, Inc.
- ---------------------------

TERM OF CRADA: Three (3) years.
- -------------------------------

The Research Plan which follows this page should be concise but of sufficient
detail to permit reviewers of this CRADA to evaluate the scientific merit of the
proposed collaboration. The RP should explain the scientific importance of the
collaboration and the research goals of PHS and the COMPANY. The respective
contributions in terms of expertise and/or research materials of each of the
Parties should be summarized. Initial and subsequent projects contemplated under
the RP, and the time periods estimated for their completion, should be described
and pertinent methodological considerations summarized. Pertinent literature
references may be cited and additional relevant information included. Include
additional pages to identify the Principal Investigators of all other Parties to
this CRADA.


                             NHGRI-Sequenom CRADA
                          Appendix A (Research Plan)
                                  Page 1 of 9


     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission.
<PAGE>

                                      ***

                             NHGRI-Sequenom CRADA
                          Appendix A (Research Plan)
                                  Page 2 of 9

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission.
<PAGE>

                                      ***

                             NHGRI-Sequenom CRADA
                          Appendix A (Research Plan)
                                  Page 3 of 9

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

                                      ***

                             NHGRI-Sequenom CRADA
                          Appendix A (Research Plan)
                                  Page 4 of 9

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission.
<PAGE>

                                      ***

                             NHGRI-Sequenom CRADA
                          Appendix A (Research Plan)
                                  Page 5 of 9

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission.

<PAGE>

                                      ***

                             NHGRI-Sequenom CRADA
                          Appendix A (Research Plan)
                                  Page 6 of 9

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission

<PAGE>

                                      ***

                             NHGRI-Sequenom CRADA
                          Appendix A (Research Plan)
                                  Page 7 of 9

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission.

<PAGE>

    these assays specifically for MS, will be necessary in order to optimize
    multiplexing while still insuring robust, high-resolution discrimination of
    alleles at multiplexed loci.

4)  ABSTRACT OF THE RESEARCH PLAN FOR PUBLIC RELEASE

This is a two-way CRADA between two NHGRI laboratories (IDRB and GMBB) and
Sequenom, Inc. to develop SNP genotyping assays suitable for mass spectroscopy
such that multiple loci can be genotyped in parallel.  The IDRB aims to develop
and test approximately *** SNPs across the genome whereas the GMBB's main goal
is to identify and test approximately *** SNPs targeted in candidate regions for
diabetes.  Publicly available anonymous and intragenic polymorphisms may be
targeted for assay development.

5)  RELATED CRADAs

None

6)  RELATED MTAs

None

7)  Related patent applications and patents

None

8)  CRADA Conflict of Interest and Fair Access Form

Attached.

                             NHGRI-Sequenom CRADA
                          Appendix A (Research Plan)
                                  Page 8 of 9

***  Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission.

<PAGE>

                                      ***

                            NHGRI - Sequenom CRADA
                          Appendix A (Research Plan)
                                  Page 9 of 9


*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission.
<PAGE>

                                  APPENDIX B

           FINANCIAL AND STAFFING CONTRIBUTIONS OF THE CRADA PARTIES


                                      ***


                                NHGRI-Sequenom
                            Appendix B, Page 1 of 1


     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission.
<PAGE>

                                  APPENDIX C

                   EXCEPTIONS OR MODIFICATIONS TO THIS CRADA

1)   Modify the definition of 2.10 Subject Invention by adding ***. Furthermore
     it is understood that DNA MassArray(TM), defined as nucleic acid analysis
     from arrays by mass spectrometry, which includes existing processes,
     methods, instrumentation that are proprietary to the Collaborator, is a
     platform technology that will be utilized to carry out the Research Plan."
     to the end of the first sentence.

     Paragraph 2.10 reads as follows:

     2.10 "Subject Invention" means any Invention of the Parties, conceived or
          first actually reduced to practice in the performance of the Research
          Plan of this CRADA, ***. Furthermore it is understood that DNA
          MassArray(TM), defined as nucleic acid analysis from arrays by mass
          spectrometry, which includes existing processes, methods,
          instrumentation that are proprietary to the Collaborator, is a
          platform technology that will be utilized to carry out the Research
          Plan.

2)   Within Article 6 Patent Applications add new subarticles 6.2 Collaborator
     Employee Inventions, 6.3 PHS Employee Inventions and 6.4 Joint Inventions.
     Renumber all subsequent subparagraphs of Paragraph 6 (e.g., 6.2-6.4
     renumbered as 6.5-6.7, respectively).

     6.2  Collaborator Employee Inventions.  Collaborator may elect to retain
          intellectual property rights to each Subject Invention made solely by
          Collaborator employees.  If Collaborator does not elect to retain its
          intellectual property rights, Collaborator shall offer to assign these
          intellectual property rights to the Subject Invention to the other
          Party pursuant to Article 6.5.  If PHS declines such assignment,
          Collaborator may release its intellectual property rights as it may
          determine.

                                NHGRI-Sequenom
                Appendix C--Modifications to PHS 3/15/99 model
                                  Page 1 of 5


     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission.
<PAGE>

     6.3  PHS Employee Inventions. PHS on behalf of the U.S. Government may
          elect to retain intellectual property rights to each Subject Invention
          made solely by PHS employees. If PHS does not elect to retain
          intellectual property rights, PHS shall offer to assign these
          intellectual property rights to such Subject Invention to the other
          Party pursuant to Article 6.5. If Collaborator declines such
          assignment, PHS may release intellectual property rights in such
          Subject Invention to its employee inventors pursuant to Article 6.5.

     6.4  Joint Inventions.  Each Subject Invention made jointly by PHS and
          Collaborator shall be jointly owned by the PHS and Collaborator.  If
          any Party decides not to retain its intellectual property rights to a
          jointly owned Subject Invention, it shall offer to assign its rights
          to the other inventing Party pursuant to Article 6.6.  If the other
          Parties declines such assignment, the offering Party may dispose of
          its intellectual property rights as provided in Articles 6.2, 6.3 and
          6.5.

3)   Add the following two sentences to the beginning of Paragraph 6.5 Filing of
     Patent Applications: "It is understood by Collaborator that it is the
     policy of NIH to consider filing patent applications only on discoveries
     where there is a clear demonstration that patent protection and
     commercialization of these discoveries will result in a benefit to the
     public health.  In NIH's view, raw genomic DNA sequence, in the absence of
     demonstrated biological information, lacks demonstrated specific utility
     and therefore such information and/or discoveries are considered
     inappropriate material for patent filing."

     Paragraph 6.5 reads as follows:

     6.5  Filing of Patent Applications. It is understood by Collaborator that
          it is the policy of NIH to consider filing patent applications only on
          discoveries where there is a clear demonstration that patent
          protection and commercialization of these discoveries will result in a
          benefit to the public health. In NIH's view, raw genomic DNA sequence,
          in the absence of demonstrated biological information, lacks
          demonstrated specific utility and therefore such information and/or
          discoveries are considered inappropriate material for patent filing.
          Each party shall be responsible for filing patent or other IP
          applications in a timely manner and at its own expense and after
          consultation with the other Party. The Parties will consult and
          mutually determine a filing strategy for jointly owned subject
          inventions.

4)   In the last sentence of 6.6 Patent Expenses add "or nonexclusive" after
     "Collaborator may waive its exclusive" and before "...license rights on any
     application, patent or other intellectual property grant."

     Paragraph 6.6 reads as follows:

                                NHGRI-Sequenom
                Appendix C--Modifications to PHS 3/15/99 model
                                  Page 2 of 5
<PAGE>

     6.6  Patent Expenses. The Party filing such application generally shall pay
          the expense attendant to the filing of patent or other intellectual
          property applications. If an exclusive license to any Subject
          Invention is granted to Collaborator, Collaborator shall be
          responsible for all past and future out-of-pocket expenses in
          connection with the preparation, filing, prosecution and maintenance
          of any applications claiming such exclusively-licensed inventions and
          any patents or other intellectual property grants that may issue on
          such applications. Collaborator may waive its exclusive or
          nonexclusive license rights on any application, patent or other
          intellectual property grant at any time, and incur no subsequent
          compensation obligation for that application, patent or intellectual
          property grant.

5)   Add the following new second sentence to Article 7.1 Option for
     Commercialization License: "The exclusive commercialization license option
     only applies to DNA MassArray(TM) specific Subject Inventions generated
     under this CRADA."

Article 7.1 now reads as follows:

     7.1  Option for Commercialization License. With respect to Government IP
          rights to any Subject Invention not made solely by the Collaborator's
          employees for which a patent or other IP application is filed, PHS
          hereby grants to the Collaborator an exclusive option to elect an
          exclusive or nonexclusive commercialization license, which is
          substantially in the form of the appropriate model PHS license
          agreement The exclusive commercialization license option only applies
          to DNA MassArray(TM) -specific Subject Inventions generated under this
          CRADA. This option does not apply to Subject Inventions conceived
          prior to the effective date of this CRADA that are reduced to practice
          under this CRADA, if prior to that reduction to practice, PHS has
          filed a patent application on the invention and has licensed it or
          offered to license it to a third party. The terms of the license will
          fairly reflect the nature of the invention, the relative contributions
          of the Parties to the invention and the CRADA, the risks incurred by
          the Collaborator and the costs of subsequent research and development
          needed to bring the invention to the marketplace. The field of use of
          the license will be commensurate with the scope of the RP.

6)   In the first sentence of Article 7.5-Third Party license add the word
     "Collaborator's" after "...or exclusive sublicense to use the invention in"
     and before "licensed field of use on terms that are reasonable under the
     circumstances; or if the Collaborator fails to grant such a license, to
     grant the license itself."

     Article 7.5 reads as follows:


                                NHGRI-Sequenom
                Appendix C--Modifications to PHS 3/15/99 model
                                  Page 3 of 5
<PAGE>

     7.5  Third Party License.  Pursuant to 15 U.S.C. (S) 3710a(b)(1)(B), if PHS
          grants an exclusive license to a Subject Invention made wholly by PHS
          employees or jointly with a Collaborator under this CRADA, pursuant to
          Articles 6.3 and 6.4, the Government shall retain the right to require
          the Collaborator to grant to a responsible applicant a nonexclusive,
          partially exclusive, or exclusive sublicense to use the invention in
          Collaborator's licensed field of use on terms that are reasonable
          under the circumstances; or if the Collaborator fails to grant such a
          license, to grant the license itself.  The exercise of such rights by
          the Government shall only be in exceptional circumstances and only if
          the Government determines (i) the action is necessary to meet health
          or safety needs that are not reasonably satisfied by Collaborator,
          (ii) the action is necessary to meet requirements for public use
          specified by Federal regulations, and such requirements are not
          reasonably satisfied by the Collaborator; or (iii) the Collaborator
          has failed to comply with an agreement containing provisions described
          in 15 U.S.C. 3710a(c)(4)(B).  The determination made by the Government
          under this Article is subject to administrative appeal and judicial
          review under 35 U.S.C. 203(2).

7)   Add the following three sentences to the end of Article 8.1 Right of
     Access: "The Parties agree that DNA sequence information (such as SNPs and
     related genotype and/or phenotype information), associated research
     reagents, methodologies and/or data previously generated by NIH, or newly
     generated under this CRADA by NIH, are Research Resources.  NIH reserves
     the right to distribute such resources and researches tools to others and
     use them for their own purposes.  The Parties further agree that data
     generated by any Party through the use of such Research Resources with
     anyone other than the Parties to this Agreement does not constitute Subject
     Data."

     Article 8.1 now reads as follows:

     8.1  Right of Access. PHS and the Collaborator agree to exchange all
          Subject Data produced in the course of research under this CRADA.
          Research Materials will be shared equally by the Parties to the CRADA
          unless other disposition is agreed to by the Parties. The Parties
          agree that DNA sequence information (such as SNPs and related genotype
          and/or phenotype information), associated research reagents,
          methodologies and/or data previously generated by NIH, or newly
          generated under this CRADA by NIH, are Research Resources. NIH
          reserves the right to distribute such resources and researches tools
          to others and use them for their own purposes. The Parties further
          agree that data generated by any Party through the use of such
          Research Resources with anyone other than the Parties to this
          Agreement does not constitute Subject Data.

8)   In the last sentence of 8.2 Ownership of Subject Data and Research
     Materials add "...except that any Research Resources and/or data generated
     under this CRADA are subject to NIH's right to distribute them to others
     and use them for its own purposes"

                                NHGRI-Sequenom
                Appendix C--Modifications to PHS 3/15/99 model
                                  Page 4 of 5
<PAGE>

     after "Jointly developed Subject Inventions, Subject Data and Research
     Materials will be jointly owned."

     Article 8.2 reads as follows:

     8.2  Ownership of Subject Data and Research Materials. Subject to the
          sharing requirements of Paragraph 8.1 and the regulatory filing
          requirements of Paragraph 8.3, the producing Party will retain
          ownership of and title to all Subject Inventions, all Subject Data and
          all Research Materials produced solely by their investigators. Jointly
          developed Subject Inventions, Subject Data and Research Materials will
          be jointly owned except that any Research Resources and/or data
          generated under this CRADA are subject to NIH's right to distribute
          them to others and use them for its own purposes.

9)   In the first sentence of 8.6 Duration of Confidentiality Obligation change
     the term from three (3) years to five (5) years.

     Article 8.6 reads as follows:

     8.6  Duration of Confidentiality Obligation. The obligation to maintain the
          confidentiality of Proprietary/Confidential Information shall expire
          at the earlier of the date when the information is no longer
          Proprietary Information as defined in Article 2.7 or five (5) years
          after the expiration or termination date of this CRADA. The
          Collaborator may request an extension to this term when necessary to
          protect Proprietary/Confidential Information relating to products not
          yet commercialized.

                                NHGRI-Sequenom
                Appendix C--Modifications to PHS 3/15/99 model
                                  Page 5 of 5

<PAGE>

                                                                   EXHIBIT 10.38

                                 SEQUENOM INC.

                             EMPLOYMENT AGREEMENT

          This Agreement is entered into between Sequenom, Inc. a Delaware
corporation (the "Company") and [NAME] (the "Employee").  In consideration of,
and as a condition of Employee's employment by Company, and of the compensation
to be paid to Employee by Company, and in recognition of the fact that Employee
will have access to the Company's confidential, proprietary, and trade secret
information, Company and Employee agree as follows:

          1.   Employment Status. The Company hereby employs Employee, and
Employee hereby accepts employment, as [TITLE], effective [DATE] (the "Effective
Date"), on the terms and conditions set forth in this Agreement. Employee will
perform for the Company such duties as may be designated by the Company from
time to time. Employee agrees that Employee's employment with the Company is on
an at will basis, is for no specified term and may be terminated by the Company
at any time, with or without cause, in accordance with section 13 of this
agreement. Similarly, Employee may terminate employment with the Company at any
time, with or without cause upon written notice as provided in section 13(e) of
this agreement. Employee understands and agrees that the at will nature of
Employee's employment relationship with Company cannot be changed or modified,
except by a written agreement signed by the Chief Executive Officer of Company.
The termination of employment shall not release the Employee from the
obligations respecting the subject matter of any invention, trade secrets, and
other confidential or proprietary business information as set forth in this
Agreement and/or as established by applicable laws or Company policies. If the
Company terminates Employee's employment, without cause, in accordance with
Section 14 of this Agreement, the Company will pay Employee severance in the
form of continuation of Employee's base salary and health insurance for a
maximum of six months from the termination date. Company shall have the right to
condition the payment of any severance upon the delivery by Employee to the
Company of a legal release (in form and substance satisfactory to the Company)
of any and all claims (known or unknown) Employee may have against the Company
and its directors, officers, subsidiaries, affiliates, employees, stockholders,
successors, assigns, agents and representatives arising out of or related to
Company's hiring of Employee, Employee's employment by Company, and the
termination of such employment.

          2.   Duties of Employee. Employee shall report to the [TITLE] of the
Company and shall have overall responsibility for [DEPARTMENT RESPONSIBILITIES],
which includes areas such as [SPECIFIC RESPONSIBILITIES]. Employee shall perform
such other duties and have such other responsibilities as may be assigned to
Employee from time to time by the [SUPERIOR] of the Company. As long as Employee
is employed by the Company, Employee shall devote full time and efforts to the
Company and shall not, without the Company's prior expressed written consent,
engage directly or indirectly in any employment, consulting or business activity
other than for the Company.
<PAGE>

          3.   Compensation and Benefits.

          (a)  Employee's compensation as [TITLE] shall have the following
components: (i) base salary at the rate of [AMOUNT 1] per year payable in
accordance with the Company's standard payroll policy, and (ii) a bonus of
[AMOUNT 2] payable upon execution of this Employment Agreement,

          (b)  During each full year that Employee is employed by Company under
this Agreement, Company shall provide Employee a bonus of [AMOUNT 3] in addition
to Employee's base salary. This bonus shall be paid pro-rata throughout each
year of Employee's employment with Company.

          (c)  On or about [DATE] the Company shall grant to Employee stock
options to purchase up to [AMOUNT 4] shares of the common stock of the Company,
$0.001 par value per share. The exercise price for the stock options granted to
Employee shall be at least equal to the fair market value, as determined by the
Board of Director, of the common stock of the Company on the date of grant of
such option. The stock options shall be vested at the rate of 25% of the shares
granted on each yearly anniversary of the option grant, commencing with the
first such anniversary and conditioned on Employee's continued employment.

          (d)  An additional [AMOUNT 5] stock options will be granted by Company
to Employee upon his achievement of (milestone 1) [MILESTONE DESCRIPTION 1]. The
exercise price for the stock options granted to Employee shall be at least equal
to the fair market value, as determined by the Board of Directors, of the common
stock of the Company on the date of grant of such option. These stock options
shall be 100% vested upon the employees' successful completion of the milestone
objective.

          (e)  An additional [AMOUNT 6] stock options will be granted by Company
to Employee upon his achievement of (milestone 2) [MILESTONE DESCRIPTION 2]. The
exercise price for the stock options granted to Employee shall be at least equal
to the fair market value, as determined by the Board of Directors, of the common
stock of the Company on the date of grant of such option. These stock options
shall be 100% vested upon the employees' successful completion of the milestone
objective.

          (f)  Employee shall be reimbursed for reasonable expenses, up to a
maximum of [AMOUNT 7], associated with Employee's relocation to San Diego,
California to work for Company. Reimbursable relocation expenses include moving
company fees, transportation for Employee and Employee's family to San Diego,
temporary housing and local transportation costs (e.g. car rental) in San Diego,
and such other relocation-related costs as the Company and Employee agree shall
be reimbursable.

          (g)  During each of the first three months of this Agreement, the
Company will provide to Employee a [AMOUNT 8] monthly allowance to offset
Employee's anticipated additional housing and auto expenses.
<PAGE>

          (h)  Employee shall be entitled to participate in such employee
benefit plans and to receive such other fringe benefits as are customarily
afforded Company employees. Employee understands that, except when prohibited by
applicable law, the Company's employee benefit plans and fringe benefits may be
amended, enlarged, diminished or terminated by the Company from time to time, in
its sole discretion.

          (i)  Upon submission of itemized expense statements in the manner
specified by Company, the Company will pay Employee's reasonable travel and
other reasonable business expenses incurred by Employee in the furtherance of
and in connection with Employee's employment hereunder.

          4.   Employee's Performance.

          (a)  Employee shall use best efforts to perform assigned duties
diligently, loyally, conscientiously, and with reasonable skill, and shall
comply with all rules, procedures and standards promulgated from time to time by
the Company. Among such rules, procedures and standards are those governing
ethical and other professional standards for dealing with customers, government
agencies, vendors, competitors, consultants, fellow employees, and the public-
at-large; security provisions designed to protect Company property and the
personal security of Company employees; rules respecting attendance,
punctuality, and hours of work; and, rules and procedures designed to protect
the confidentiality of the Company's proprietary/trade secret information. The
Company agrees to make reasonable efforts to inform Employee of such rules,
standards and procedures as are in effect from time to time.

          (b)  Employee hereby represents and warrants (i) that Employee has the
full right to enter into this Agreement and perform the services required of
hereunder, without any restriction whatsoever, (ii) that in the course of
performing services hereunder, Employee will not violate the terms or conditions
of any agreement between Employee and any third party or infringe or wrongfully
appropriate any patents, copyrights, confidential information, trade secrets or
other intellectual property rights of any person or entity anywhere in the
world., (iii) that listed on Attachment A to this Agreement are the names of all
                             ------------
third parties with whom Employee has entered into employment or employment
confidentiality agreements, and (iv) Employee shall provide a copy of each such
agreement referenced in subpart (iii) to Company.

          (c)  While employed by the Company, Employee will not engage in other
employment without the Company's consent, or engage in any activities determined
by the Company to be detrimental to the best interests of the Company. Employee
will refer to the Company, all corporate opportunities Employee learns of as a
result of service of an employee of the Company.

          5.   Company's Management Rights.  The Company retains its full
management prerogatives and discretion to manage and direct its business
affairs, including the adoption, amendment or modification of research,
development, production or marketing decisions as it sees fit, notwithstanding
any individual interest in, or expectation, Employee may have regarding a
particular business program or product.
<PAGE>

          6.   Nondisclosure of Confidential, Proprietary or Trade Secret
Information. Employee acknowledges that during the term of this Agreement,
Employee will receive and have access to confidential, proprietary and trade
secret information concerning the Company. Confidential, proprietary and trade
secret information is defined as any information, formula, process, pattern,
program, device, method or technique, or any compilation of information that the
Company designates as confidential, proprietary and/or as trade secrets.
Information currently designated as confidential, proprietary and trade secret,
includes any and all technical and nontechnical information including copyright,
trade secrets, know-how, processes, software programs and formulae related to
the current, future and proposed products and services of the Company, and
includes, without limitation, its respective information concerning scientific
matters, manufacturing operations and processes, compositions, ingredients,
devices, methods, machinery, apparatus, tools, appliances, experiments,
research, inventions, designs and drawings, plans, books, customers, suppliers,
prices, costs, discounts, production, sales, inventories, properties, financial
information, customer lists, business forecasts, marketing plans and any other
information which if disclosed might be harmful or adverse to the interests of
the Company. Information currently designated as confidential, proprietary or
trade secret information also includes confidential, proprietary or trade secret
information of any third party that may disclose such information to the Company
or Employee in the course of Company's business. During employment under this
Agreement and after termination of employment, Employee shall not, without prior
written consent of the Company, publish or use or disclose to anyone other than
authorized Company personnel, any of the Company's confidential, proprietary
and/or trade secret information. Employee agrees to abide by Company policies
and regulations for the protection of confidential, proprietary and trade secret
information. Employee understands and agrees that the unauthorized disclosure or
misuse of such confidential, proprietary or trade secret information could
irreparably damage the Company and/or third parties dealing with the Company.

          7.   No Solicitation of Customers or Employees. Employee acknowledges
that the Company has invested substantial time, effort and expense in compiling
its confidential, proprietary and trade secret information and in assembling its
present staff of personnel. In order to protect the business value of the
Company's confidential, proprietary and trade secret information, during
Employee's employment with the Company and for one year immediately following
the termination of that employment with the Company:

          (a)  Employee agrees that all customers and all prospective customers,
of the Company, that Employee has contact with during Employee's employment with
the Company, shall be solely the customers of the Company.

          (b)  Employee agrees not to, either directly or indirectly, solicit
business, as to products or services competitive with those of the Company, from
any of the Company's customers or prospective customers with whom Employee had
contact during employment with the Company.

          (c)  Employee agrees not to, directly or indirectly, induce or solicit
any of the Company's employees to leave their employment with the Company.
<PAGE>

          8.   Inventions.  Employee agrees that any and all inventions, ideas,
techniques, methods, formulas, processes, developments and improvements which
the Employee conceives, makes, or obtains during employment with the Company,
either solely or in conjunction with others, and which result from any work
performed by Employee for the Company or which relates to the Company's
business, or actual or demonstrably anticipated research or development
conducted by or for the Company, shall be the sole and exclusive property of the
Company. Employee agrees to promptly disclose to the Company, in writing, the
existence of any inventions, discoveries, or ideas that may be directly or
indirectly useful in the Company's business, whether or not patentable, which
Employee develops or conceives during the term of employment with Company,
regardless of whether done alone or in conjunction with others and regardless of
whether done during regular working hours. Employee hereby agrees to assign,
shall assign, and hereby does assign to the Company, Employee's entire right,
title and interest in such inventions, discoveries and ideas. Employee further
agrees to execute all applications, assignments, contracts and other
instruments, as the Company deems necessary to effectuate the intent of this
section of the Agreement. The foregoing shall not apply to any inventions,
discoveries or ideas that Employee has developed or conceived prior to becoming
employed by Company. All such inventions, discoveries and ideas that Employee
conceived prior to becoming employed by the Company, if any, have been listed by
Employee in Attachment B to this Agreement. Similarly, the foregoing shall not
            ------------
apply to any inventions that qualify under section 2870 of the California Labor
Code. Labor Code section 2870 pertains to inventions, discoveries or ideas
developed entirely by Employee on Employee's own time without using the
Company's equipment, supplies, facilities or trade secrets; provided that the
inventions, discoveries or ideas do not relate to the Company's business or the
actual or demonstrably anticipated research or development conducted by the
Company, and further provided that such inventions, discoveries or ideas do not
result from any work performed by Employee for the Company.

          9.   Property of the Company. Employee agrees that all originals and
all copies of all manuscripts, drawings, prints, manuals, diagrams, letters,
notes, notebooks, reports, models, records, files, computerized data and
programs, memoranda, plans, sketches and all other documents and materials
containing, representing, evidencing, recordings, or constituting any
Confidential Information (as those terms are defined in Section 6, above),
however, and whenever produced (whether by Employee or others), shall be the
sole property of the Company. Employee agrees that all such Confidential,
Proprietary or Trade Secret Information and all other discoveries, inventions,
ideas, concepts, research and other information, processes, products, methods
and improvements, or parts thereof (including without limitation all inventions,
discoveries, and innovations with regard to physics, chemistry, enzymology,
biology, medicine, biotechnology, genetic engineering or recombinant DNA)
conceived, developed, or otherwise made by Employee, alone or jointly with
others and in any way relating to the Company's present or proposed technology
projects, products, programs or services or to tasks assigned to Employee during
the course of Employee's employment, whether or not patentable or subject to
copyright protection and whether or not reduced to tangible form or reduced to
practice during the period of Employee's employment with the Company, whether or
not made during Employee's regular working hours, and whether or not made on the
Company's premises, and whether or not disclosed by Employee to the Company
(hereinafter referred to as "Developments") together with anything which
embodies or emulates such Developments shall be the sole property of the
Company. Except as provided in Section 8, Employee agrees to, and
<PAGE>

hereby does, assign to the Company all of Employee's right, title and interest
throughout the world in and to all Developments and to anything tangible which
evidences, incorporates, constitutes, represents or records any such
Developments. Employee agrees that all such Developments shall constitute works
made for hire under the copyright laws of the United States and does hereby
assign and, to the extent any such assignment cannot be made at present, hereby
agrees to assign to the Company all copyrights, patents and other proprietary
rights Employee may have in any such Developments, together with the right to
file for, and/or own wholly without restriction, United States and foreign
patents, trademarks, and copyrights. Employee agrees to waive, and hereby does
waive all proprietary rights in or to any Developments and, to the extent that
such rights may not be waived as a matter of law, agrees not to assert such
rights against the Company or its licensees, successors or assignees. Employee
shall make and maintain adequate and current written records of all
Developments, which records shall be available to and remain the property of the
Company at all times. Employee shall disclose all Developments promptly, fully
and in writing to the Company immediately upon production or development of the
same and at any time upon request of the Company.

          10.  Employee's Obligation to Cooperate.  At the request of the
Company, Employee will, at all times during Employee's employment and after
termination of employment, execute all documents and perform all lawful acts
which the Company considers necessary or advisable to secure its rights
hereunder and to carry out the intent of this Agreement. Without limiting the
generality of the foregoing, Employee will assist the Company in any reasonable
manner to obtain for Company's own benefit, patents or copyrights in any and all
countries with respect to all Inventions and Developments assigned to Company
pursuant to Sections 8 and 9. Employee will execute, when requested, patent and
other applications and assignments thereof to the Company, or persons designated
by it, and any other lawful documents deemed necessary by the Company to carry
out the purposes of this Agreement. Employee will further assist the Company in
every way to enforce any patents and copyrights obtained, including, without
limitation, testifying in any suit or proceeding involving any of said patents
or copyrights or executing any documents deemed necessary by the Company, all
without further consideration than provided for herein.

          11.  Return of Property. Upon the termination of Employee's employment
with the Company, or at any other time upon request of the Company, Employee
shall promptly return any and all customer or prospective customer lists, other
customer or prospective customer information or related materials, formulas,
computer data and programs, specifications, drawings, blueprints, data storage
devices, reproductions, sketches, notes, memoranda, reports, records, proposals,
business plans, or copies of them, other documents, materials, tools, equipment,
and all other property belonging to the Company or its customers which Employee
then possesses. Employee further agrees, that upon termination of employment,
Employee shall not take any documents or data of any description containing or
pertaining to the Company's Confidential, Proprietary or Trade Secret
Information or Developments, as those terms are defined in Sections 6 and 9.
Upon leaving the Company's employment, Employee agrees to sign a Termination
Certificate confirming that Employee has complied with the requirements of this
Section of the Agreement and that Employee is aware that certain restrictions
imposed by this Agreement continue after termination of Employee's employment.
Employee further understands, however, that Employee's continuing obligations
under this Agreement will continue even if Employee does not sign a Termination
Certificate.
<PAGE>

          12.   Employee's Other Obligations. Employee acknowledges that the
Company, from time to time, may have agreements with other persons, including
the governments of the United States or other countries and agencies thereof,
which impose obligations or restrictions on the Company regarding inventions
made during the course of work thereunder or regarding the confidential nature
of such work. Employee agrees to be bound by all such obligations and
restrictions and to take all action necessary to discharge the obligations of
the Company thereunder.

          13.   Termination.  Employee's employment hereunder shall terminate
upon the occurrence of any of the following events:

          (a)   The death or legal incapacity of Employee.

          (b)   Written notice of termination from the Company to Employee as a
result of Employee's incapacity or inability to further perform services as
contemplated herein for a period aggregating 90 days or more within any six-
month period, because Employee's physical or mental health has become so
impaired as to make it impossible or impractical for Employee to perform the
duties and responsibilities contemplated hereunder.

          (c)   Written termination notice from the Company to Employee of
Employee's employment termination by the Company for Cause (as hereafter
defined). The Company shall have "Cause" for termination of Employee's
employment if any of the following occur:

          i.    Employee is convicted of, or pleaded guilty or nolo contenders
                to, any felony, or any lesser crime or offense having as its
                predicate element fraud or dishonesty;

          ii.   Employee misappropriates, steals or converts any of the property
                of the Company;

          iii.  Employee knowingly and willfully perpetrates any act or omission
                which submits the Company to criminal liability, or knowingly
                and willfully cause the Company to commit a material violation
                of local, state or federal laws, rules or regulations;

          iv.   Employee breaches any provision of this Agreement;

          v.    Employee breaches any provision of any other agreement between
                Employee and the Company and such breach has a material adverse
                effect on the Company or any of its direct or indirect
                subsidiaries; or

          vi.   Employee fails or refuses to perform assigned duties and such
                failure or refusal continues for a period of 10 days following
                written notice from the Company.
<PAGE>

          (d)  Written notice from the Company to Employee that Employee's
               employment is being terminated without cause; or

          (e)  Employee's written notice of resignation to the Company. Employee
               agrees to provide Company with four weeks notice of employees'
               intent to resign and employees resignation shall not become
               effect until the end of that four week notice period unless
               employee and company mutually agree otherwise.

          14.  Payment After Termination. Following termination of Employee's
employment, all payments and benefits provided to Employee under this Agreement
shall cease as of the date of such termination, except that in the event
Employee's employment is terminated by the Company pursuant to Section 13(d),
then for the "Severance Pay Period" (as hereafter defined): (i) the Company
shall pay Employee severance pay according to Section 1, such payments to be
made at the same time as Employee's salary otherwise would have been payable,
and (ii) if and to the extent that following such termination of employment
Employee and Employee's family members are eligible to continue to be covered
under the Company's group health insurance plan in effect at the time of such
termination of employment, if any, the Company shall pay the premiums for such
insurance coverage on Employee's behalf to the same extent the Company paid
those premiums during Employee's employment. The term "Severance Pay Period"
shall mean the period commencing on the effective date of the termination of
Employee's employment under Section 13(d) and ending on the earlier to occur of
Employee's commencement of employment for another employer, or six months
subsequent to the date of Employee's termination. During the "Severance Pay
Period," Employee will be available to consult with the Company without the
payment of additional compensation by the Company, and Employee will promptly
notify the Company if Employee commences employment with another employer.

          15.  Arbitration. Any controversy or claim arising out of or relating
to this Agreement or the Company's employment of Employee (including, but not
limited to claims arising under Title VII of the Civil Rights Act of 1964, the
Age Discrimination in Employment Act, the Americans with Disabilities Act, the
California Fair Employment and Housing Act, the California Labor Code, the
California Constitution or any other federal, state or local statutes or common
law) or any dispute arising out of the interpretation or application of this
Agreement, which the Company and Employee are unable to resolve, shall be
finally resolved and settled exclusively by arbitration in San Diego, California
by a single arbitrator who is mutually selected by the Company and Employee. If
the Company and Employee cannot agree upon an arbitrator, then each party shall
choose its own independent representative and those independent representatives
shall in turn choose the single arbitrator within thirty days of the date of the
selection of the first independent representative. The Company and Employee
severally recognize and consent to the jurisdiction over each of them by the
courts of the state of California.
<PAGE>

          16.  Miscellaneous.

          (a)  Entire Agreement. This Agreement represents the Company's and
Employee's entire understanding with respect to the subject matter contained in
this Agreement and supersedes all previous understandings, written or oral
between the Company and Employee concerning the subject matters of this
Agreement. This Agreement may be amended or modified only with the signed
written consent of both the Company and Employee. No oral waiver, amendment or
modification shall be effective under any circumstances whatsoever.

          (b)  Post-Employment Application of this Agreement. This Agreement (1)
shall remain in effect after the termination of Employee's employment by the
Company, regardless of the reason the employment relationship ends, (2) does not
in any way restrict Employee's right, or the right of the Company, to terminate
Employee's employment at will and at any time, for any reason or for no reason,
(3) inures to the benefits of successors and assigns of the Company, and (4) is
binding upon Employee's heirs and legal representatives.

          (c)  Severability.  Should any provisions of this Agreement be held by
a court of law to be illegal, invalid or unenforceable, the legality, validity
and enforceability of the remaining provisions of this Agreement shall not be
affected or impaired thereby.

          (d)  Injunctive Relief.  Employee recognizes that money damages alone
would not adequately compensate the Company in event of any breach by Employee
of Sections 6-12 of this Agreement . Therefore, Employee agrees that, in
addition to all other remedies available to the Company at law, in equity, or
otherwise, the Company shall be entitled to injunctive relief to restrain any
breach of said Sections and to enforce the provisions hereof, without showing or
proving any actual damage to the Company or posting any bond.

          (e)  Non-Waiver. No failure by the Company to insist upon strict
compliance with any of the terms, covenants, or conditions hereof, and no delay
or omission by the Company in exercising any right under this Agreement, will
operate as a waiver of such terms, covenants, conditions or rights. A waiver or
consent given by the Company on any one occasion is effective only in that
instance and will not be construed as a bar to or waiver of any right on any
other occasion.

          (f)  Governing Law. This Agreement shall be governed in all respects
by the laws of the United States of America and by the laws of the State of
California.

          (g)  Notices. Any notice required or permitted by this Agreement shall
be in writing and shall be delivered as follows with notice deemed given as
indicated: (1) by personal delivery when delivered personally; (2) by overnight
courier upon written verification of receipt; (3) by telecopy or facsimile
transmission upon acknowledgment of receipt of electronic transmission; or (4)
by certified or registered mail, return receipt requested, upon verification of
receipt. Notices to the Employee shall be sent to the last known address in the
Company's records or such other address as the Employee may specify in writing.
Notices to the Company shall be sent to the Company's Chief Executive Officer to
such other Company representative as the Company may specify in writing.
<PAGE>

BY PLACING MY SIGNATURE HEREUNDER, I ACKNOWLEDGE THAT I HAVE READ ALL THE
PROVISIONS OF THIS AGREEMENT AND THAT I AGREE TO ALL OF ITS TERMS.

                                    [EMPLOYEE NAME]

[DATE]                              _________________________________

                                    _________________________________
                                    Employee's Signature
                                    [EMPLOYEE ADDRESS]

                                    Accepted
[DATE]                              SEQUENOM, INC.
                                    [BY]:
                                    _________________________________

                                    [TITLE]:

                                    _________________________________
<PAGE>

ATTACHMENT A

LIST OF THE NAMES OF ALL THIRD PARTIES WITH WHOM EMPLOYEE HAS ENTERED INTO
EMPLOYMENT OR EMPLOYMENT CONFIDENTIALITY AGREEMENTS, EMPLOYEE PRIOR TO BEGINNING
EMPLOYMENT WITH COMPANY.


A.   The following lists all are the names of all third parties with whom
Employee has entered into employment or employment confidentiality agreements.


_____ [ADDITIONAL SHEETS ATTACHED]



[DATED]:_________________________


[EMPLOYEE]:______________________
<PAGE>

ATTACHMENT B

LIST OF INVENTIONS, DISCOVERIES OR IDEAS DEVELOPED OR CONCEIVED
OF BY EMPLOYEE PRIOR TO BEGINNING EMPLOYMENT WITH COMPANY.

A.   The following list describes all prior inventions, discoveries or ideas
     that are to be excluded from the Company's property as described in the
     Agreement on Competition, Confidentiality, Trade Secrets, Non-Solicitation
     and Inventions

[TITLE]                            [DATE]                  [IDENTIFYING NUMBER
                                                           OR BRIEF DESCRIPTION]

________________________________________________________________________________



          B.  The following list describes all inventions, discoveries or ideas
that are qualified fully under California Labor Code section 2870:



[TITLE]                            [DATE]                  [IDENTIFYING NUMBER
                                                           OR BRIEF DESCRIPTION]

________________________________________________________________________________


____ [NO INVENTIONS DISCOVERIES OR IDEAS]

____ [ADDITIONAL SHEETS ATTACHED]

____ [I AGREE TO KEEP THIS LIST CURRENT AT ALL TIMES]

[DATED]:____________________

[EMPLOYEE]:_________________
<PAGE>

                                  Schedule A
                                  ----------

                         Form of Employment Agreement.
                         ----------------------------

<TABLE>
- --------------------------------------------------------------------------------------------------
<S>              <C>
Charlie Rodi     (S)1     (Title): Vice President, Molecular Biology
                          (Date): May 17, 1999
                 (S)2     (Title): Chief Science Officer
                          (Department Responsibilities): Molecular Biology Department
                          (Specific Responsibilities): assay development, automation, cost
                 reduction, feasibility/pilot studies, development of new assay strategies
                          (Superior): Chief Science Officer
                 (S)3 (a) (Title): Vice President of Molecular Biology
                          (Amount 1): $140,000
                          (Amount 2): $30,000
                      (b) (Amount 3): $10,000
                      (c) (Date): May 15, 1999
                          (Amount 4): 30,000
                      (d) (Amount 5): 10,000
                          (Milestone Description 1): successful development of an automated
                 assay development system for SNP scoring
                      (e) (Amount 6): 10,000
                          (Milestone Description 2): reduce analysis cost per genotype three-fold
                 from current cost levels
                      (f) (Amount 7): $50,000
                      (g) (Amount 8): $1,500
                 Signature Block
                          (Date): 5/18/99
                          (Employee Name): /s/ - Charles P. Rodi
                          (Employee Address): 6632 Antigua, San Diego, CA 92124
                          (Date): [blank]
                          (By): /s/ - Hubert Koster
                          (Title): President and CEO
                 Attachment A
                      (A.): None
                          (Additional Sheets): [blank]
                          (Dated): 5/18/99
                          (Employee) /s/ - Charles P. Rodi
                 Attachment B
                      (A) (Title): [blank]
                          (Date): [blank]
                          (Identifying Number or Brief Description): [blank]
                      (B) (Title): [blank]
                          (Date): [blank]
                          (Identifying Number or Brief Description): [blank]
                          (No Inventions, discoveries or ideas): checked
                          (Additional Sheets Attached): [blank]
- --------------------------------------------------------------------------------------------------
</TABLE>
<PAGE>

<TABLE>
- --------------------------------------------------------------------------------------------------
<S>              <C>
                          (I agree to keep this list current at all times): [blank]
                          (Dated): 5/18/99
                          (Employee): /s/ - Charles P. Rodi
- --------------------------------------------------------------------------------------------------
Steve Zaniboni   (S)1     (Title): Chief Financial Officer
                          (Date): April 1, 1999
                 (S)2     (Title): Chief Executive Officer
                          (Department Responsibilities): Financial Operation of Sequenom
                          (Specific Responsibilities): Second Geschaefts-fuehrer of the
                  Hamburg location
                          (Superior): Chief Executive Officer
                 (S)3 (a) (Title): Chief Financial Officer
                          (Amount 1): $195,000
                          (Amount 2): n/a
                      (b) (Amount 3): $10,000
                      (c) (Date): 4/01/99
                          (Amount 4): 210,000
                      (d) (Amount 5): n/a
                          (Milestone Description 1): n/a
                      (e) (Amount 6): n/a
                          (Milestone Description 2): n/a
                      (f) (Amount 7): n/a
                      (g) (Amount 8): n/a
                 Signature Block
                          (Date): 9/10/99
                          (Employee Name): /s/ - Steve Zaniboni
                          (Employee Address): 12726 Chandon Court, San Diego, CA
                          (Date): 9/21/99
                          (By): /s/ - Hubert Koster
                          (Title): President and CEO
                 Attachment A
                       (A): [blank]
                          (Additional Sheets): [blank]
                          (Dated): [blank]
                          (Employee): [blank]
                 Attachment B
                      (A) (Title): [blank]
                          (Date): [blank]
                          (Identifying Number or Brief Description): [blank]
                      (B) (Title): [blank]
                          (Date): [blank]
                          (Identifying Number or Brief Description): [blank]
                          (No Inventions, discoveries or ideas): [blank]
                          (Additional Sheets Attached): [blank]
                          (I agree to keep this list current at all times): [blank]
                          (Dated): [blank]
                          (Employee): [blank]
- --------------------------------------------------------------------------------------------------
                                       2

</TABLE>
<PAGE>

<TABLE>
- --------------------------------------------------------------------------------------------------
<S>              <C>
Toni Schuh       (S)1     (Title): Executive Vice President of Business Development and
                 Marketing
                          (Date): May 1, 1999
                 (S)2     (Title): Chief Executive Officer
                          (Department Responsibilities): Business Development and
                 Marketing
                          (Specific Responsibilities): n/s
                          (Superior): Chief Executive Officer
                 (S)3 (a) (Title): Executive Vice President of Business Development and
                 Marketing
                          (Amount 1): $195,000
                          (Amount 2): n/a
                      (b) (Amount 3): $10,000
                      (c) (Date): May 1, 1999
                          (Amount 4): 280,000
                      (d) (Amount 5): n/a
                          (Milestone Description 1): n/a
                      (e) (Amount 6): n/a
                          (Milestone Description 2): n/a
                      (f) (Amount 7): n/a
                      (g) (Amount 8): n/a
                 Signature Block
                          (Date): 9/10/99
                          (Employee Name): /s/ - Toni Schuh
                          (Employee Address): 12529 -A El Camino Real, San Diego,
                 CA 92130
                          (Date): 9/21/99
                          (By): Hubert Koster
                          (Title): President and CEO
                 Attachment A
                       (A): [blank]
                          (Additional Sheets): 0
                          (Dated): 9/10/99
                          (Employee): /s/ - Toni Schuh
                 Attachment B
                      (A) (Title): [blank]
                          (Date): [blank]
                          (Identifying Number or Brief Description): [blank]
                      (B) (Title): [blank]
                          (Date): [blank]
                          (Identifying Number or Brief Description): [blank]
                          (No Inventions, discoveries or ideas): 0
                          (Additional Sheets Attached): 0
                          (I agree to keep this list current at all times): [checked]
                          (Dated): 9/10/99
                          (Employee): /s/ - Toni Schuh
- --------------------------------------------------------------------------------------------------
                                       3
</TABLE>
<PAGE>

<TABLE>
- --------------------------------------------------------------------------------------------------
<S>                <C>
Delbert Foit, Jr.  (S)1     (Title): Chief Operating Officer
                            (Date): April 5, 1999
                   (S)2     (Title): Chief Executive Officer
                            (Department Responsibilities): facilities at the San Diego and
                   Hamburg sites, the  manufacturing operations (currently only in San Diego),
                   operations of the Automated Process Lines in San Diego and Hamburg, contract
                   manufacturing if needed, external relationships, securing raw materials,
                   customer support, information technology, and on-site intranet system
                   administration
                            (Specific Responsibilities): structuring and making operational
                   various business units
                            (Superior): Chief Executive Officer
                   (S)3 (a) (Title): Chief Operating Officer
                            (Amount 1): $180,000
                            (Amount 2): n/a
                        (b) (Amount 3): $10,000
                        (c) (Date): April 5, 1999
                            (Amount 4): 100,000
                        (d) (Amount 5): n/a
                            (Milestone Description 1): n/a
                        (e) (Amount 6): n/a
                            (Milestone Description 2): n/a
                        (f) (Amount 7): $50,000
                        (g) (Amount 8): $1,000
                   Signature Block
                            (Date): March 26, 1999
                            (Employee Name): /s/ - Delbert Foit, Jr.
                            (Employee Address): 195 Mont Blanc Court, Danville, CA  94526
                            (Date): [blank]
                            (By): Hubert Koster
                            (Title): President and CEO
                   Attachment A
                        (A): 1. Roche Diagnostics Corporation, dated October 9, 1992 (signed
                   as Microgenics Corp, wholly owned subsidiary of Boehringer Mannheim
                   Corporation); 2. Ortho Diagnositics Systems, A member of Johnson and
                   Johnson Family of Companies, dated, November 1974
                            (Additional Sheets): [blank]
                            (Dated): 3/26/99
                            (Employee): /s/ - Delbert Foit, Jr.
                   Attachment B
                        (A) (Title): [blank]
                            (Date): [blank]
                            (Identifying Number or Brief Description): [blank]
                        (B) (Title): [blank]
                            (Date): [blank]
                            (Identifying Number or Brief Description): [blank]
- --------------------------------------------------------------------------------------------------
                                       4
</TABLE>
<PAGE>

<TABLE>
- --------------------------------------------------------------------------------------------------
<S>                <C>
                            (No Inventions, discoveries or ideas): [checked]
                            (Additional Sheets Attached): [blank]
                            (I agree to keep this list current at all times): [checked]
                            (Dated): 3/26/99
                            (Employee): /s/ - Delbert Foit, Jr.
- --------------------------------------------------------------------------------------------------
Paul Heaney        (S)1     (Title): Vice President of R&D/Advanced Systems Technologies
                            (Date): May 12, 1999
                   (S)2     (Title): Chief Science Officer
                            (Department Responsibilities): development of automated systems for
                   nanoliter reactions, new mass spectrometer instrumentation, and integrated
                   system solutions
                            (Specific Responsibilities): n/a
                            (Superior): Chief Science Officer
                   (S)3 (a) (Title): Vice President of R&D/Advanced Systems Technologies
                            (Amount 1): $175,000
                            (Amount 2): $15,000
                        (b) (Amount 3): $10,000
                        (c) (Date): May 15, 1999
                            (Amount 4): 50,000
                        (d) (Amount 5): 25,000
                            (Milestone Description 1): development of nanoliter Mass Array
                   system for SNP analysis miniturizing sample prep and enzymatic reactions
                   suitable for mass spec analysis
                        (e) (Amount 6): 25,000
                            (Milestone Description 2: development of a prototype of a robust
                   Array Mass Spectrometer for high throughput biopolymer analysis using UV
                   and IR mass technology
                        (f) (Amount 7): $50,000
                        (g) (Amount 8): n/a
                   Signature Block
                            (Date): 5/13/99
                            (Employee Name): /s/ - Paul Heaney
                            (Employee Address): 19 Spyglass Rd., Skillman, NJ  08558
                            (Date): [blank]
                            (By): /s/ - Hubert Koster
                            (Title): President and CEO
                   Attachment A
                          (A): No other agreements
                            (Additional Sheets): 0
                            (Dated): [blank]
                            (Employee): /s/ - Paul Heaney
                   Attachment B
                        (A) (Title): [blank]
                            (Date): [blank]
                            (Identifying Number or Brief Description): [blank]
                        (B) (Title): [blank]
- --------------------------------------------------------------------------------------------------
                                       5
</TABLE>
<PAGE>

<TABLE>
- --------------------------------------------------------------------------------------------------
<S>                         <C>
                            (Date): [blank]
                            (Identifying Number or Brief Description): [blank]
                            (No Inventions, discoveries or ideas): [checked]
                            (Additional Sheets Attached): [blank]
                            (I agree to keep this list current at all times): [blank]
                            (Dated): 5/13/99
                            (Employee): /s/ - Paul Heaney
- --------------------------------------------------------------------------------------------------
                                       6
</TABLE>

<PAGE>

                                                                   EXHIBIT 10.39

                         CONSULTING SERVICES AGREEMENT

     THIS AGREEMENT is entered into this 4st day of October, 1996, by and
between Sequenom, Inc. of Boston, MA/USA and Sequenom Instruments GmbH of
Hamburg/Germany (the "Company") and Prof. Dr. Franz Hillenkamp ("Consultant").

     NOW, THEREFORE, it is agreed as follows:

      1.  Definitions
          As used herein:

          (a)  The term "Products" shall mean the devices, reagents, kits and
diagnostic services proposed to be developed by, or with the assistance of,
Consultant hereunder as defined, and with the specifications set forth in
Exhibit A hereto.

          (b)  The term "Technology" shall mean the results and product
(interim and/or final) of the consulting services performed by Consultant
hereunder, whether tangible or intangible, including, without limitation, each
and every invention, formula, trade secret, software program (including without
limitation, object code, source code, flow charts, algorithms and related
documentation), listing, routine, manual, specification, technique, product,
concept, know-how, or similar property, whether or not patentable or
copyrightable, and whether or not embodied in any Products that are made,
developed, perfected, designed conceived or first reduced by practice by
Consultant, either solely or jointly with others, in the course and scope of the
consulting services performed hereunder.

      2.  Engagement or Performance of Services

          (a)  Engagement
               ----------
               The Company hereby engages Consultant to perform consulting
services in accordance with the terms and conditions of this Agreement. The
specific tasks and services to be performed by Consultant are set forth in
Exhibit A attached hereto. If such services include the development of specific
Products, the specifications of such Products are set forth in Exhibit A
attached hereto.

          (b)  Facilities, Equipment and Supplies
               ----------------------------------
               The Company will provide to the Consultant the facilities,
equipment and supplies specified in Exhibit A attached hereto. *** Consultant
shall, at his own cost and expense, provide all other facilities, equipment and
supplies necessary to perform the consulting services hereunder.

          (c)  Other Services
               --------------
               The Company acknowledges and agrees that, subject to its
obligations hereunder, Consultant shall have the right to engage in researches
and development and consulting activities in all areas other than ***. Such
activities in the field of *** are permissible, provided, however, that
Consultant

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

shall not perform any consulting services for an actual or potential competitor
of the Company during the term of this Agreement and for a period of one (1)
year after termination of this Agreement.

          (d)  Primary Duty
               ------------
               The Company and the Consultant recognize that Consultant's
primary duty as a member of the University of Munster (the "University") is to
the University. The Company and the Consultant agree that the University's
policies and Consultant's obligations to the University shall be observed in the
event a conflict arises with this Agreement. The same applies to funding
agencies who fund Consultant's research through research contracts with the
University of Munster or by funds administered by the University of Munster.

          (e)  Compensation
               ------------
               As compensation for the consulting services provided by
Consultant hereunder, the Company shall pay to Consultant the amounts specified,
at the time(s) specified, on Exhibit B attached hereto.

          (f)  Expenses
               --------
               In addition to the compensation specified in subsection 2(e), the
Company will pay reasonable out-of-pocket expenses incurred by Consultant and
approved in advance by the Company in the furtherance of or in connection with
the performance of consulting services hereunder.

          (g)  No Violation of Others' Rights
               ------------------------------
               Consultant represents and warrants that in the course of
performing services hereunder Consultant will not infringe or wrongfully
appropriate any patents, copyrights, trade secret rights, or other intellectual
property rights of any person or entity anywhere in the world.

      3.  Protection of Confidential Information

          On or before the date hereof, the Company and the Consultant shall
have entered into a separate agreement regarding Consultant's use of
confidential information (attached as Exhibit C).

      4.  Property Rights
          All rights, title and interest in and to the Products (if any) and the
Technology developed under this Agreement shall at all times be and remain the
sole and exclusive property of the Company, and the Products and the Technology
shall be deemed to works make for hire.  The parties agree that any patents,
trademarks or copyrights that may issue relating to any of the Products or the
Technology shall be in the name of and assigned to the Company.  Patents and
rights resulting from research and development, the results of which are
disclosed to the Company before or at the time of signature of this Agreement
can be licensed and/or sold by Company only with Consultant's written consent.
In case the Company has an interest in developing the technology, a license
agreement shall be negotiated according to standard and fair marketing
conditions.
<PAGE>

      5.  Term and Termination
          The term of this Agreement shall be as set forth in Exhibit A attached
hereto.  Unless otherwise specified in Exhibit A, either party may terminate
this Agreement at any time upon thirty ( 30) days written notice delivered to
the other.  The provision of Sections 3 and 4 hereof shall survive the
termination of this Agreement.

      6.  Miscellaneous
          (a)  Use of University's Name
               ------------------------
               With the limited exception of citing Consultant's faculty title,
the Company and its affiliates will not use the names, likeness, or logos of the
University, any of its schools or divisions in any of their fund raising or in
investment documents, general publications, advertisements, or marketing and
promotional materials without the prior written permission of the University.

          (b)  Relationship of Parties
               -----------------------
               Consultant shall at all times during the performance of his
services hereunder be an independent contractor, maintaining sole and exclusive
control over its business and operations. At no time will either party hold
itself out to be the agent, employee, lessee, sublessee, partner or joint
venturer of the other party. Neither party hereto shall have the express or
implied right or authority to assume or create any obligation on behalf of or in
the name of the other party, or to bind the other party in regard to any
contract, agreement or undertaking with any third party.

          (c)  Entire Agreement
               ----------------
               This Agreement, together with the exhibits attached hereto,
constitutes the entire Agreement between the parties relating to the subject
matter hereof and supersedes all prior written or oral negotiations,
representations or agreements.  No modification of this Agreement shall be
binding on either party unless it is in writing and signed by both parties.

          (d)  Severability
               ------------
               The provisions of this Agreement are severable, and if one or
more provisions are judicially determined to be illegal or otherwise
unenforceable, in whole or in part, the remaining provisions or portions of this
Agreement shall nevertheless be binding on and enforceable by and between the
parties hereto.

          (e)  Assignment
               ----------
               This Agreement shall inure to the benefit of and be binding upon
the successors and assigns of the parties hereto; provided, however, that
Consultant and Company shall not transfer or assign this Agreement without the
prior written consent of the other party.

          (f)  Governing Law
               -------------
               The rights and obligations of the parties to this Agreement shall
be governed by and construed in accordance with the laws of the Commonwealth of
Massachusetts.

          (g)  Headings
               --------
               Section headings are for convenience of reference only and shall
not be considered in the interpretation of this Agreement.
<PAGE>

          (h)  Unavoidable Delays
               ------------------
               Either party shall be excused for any delays or defaults in the
performance of this Agreement (except the payment of amounts due and payable
hereunder) unavoidably caused by the act of the other, the act of any agent of
the other, the act of any governmental authority, acts of God, the elements, war
litigation, strikes, walkouts, or any other cause beyond its reasonable control.
Each party shall use all reasonable diligence to avoid any such delay or default
and to resume performance under this Agreement as soon as practicable after such
delay or default.

          (i)  Notices
               -------
               All notices, requests, demands and other communications to be
given pursuant to this Agreement shall be in writing and shall be deemed to have
been duly given if delivered by hand or mailed by registered or certified mail,
return receipt requested, postage prepaid, or by facsimile transmission if a
true and correct copy is sent the same day by first class mail, postage prepaid,
or by dispatch by in internationally recognized express courier service, and in
each case addressed as follows:

               If to Consultant:   Prof. Dr. Franz Hillenkamp
               ----------------    Bahlmannstr. 5
                                   D-48147 Munster


               If to the Company:  Sequenom, Inc.
               -----------------   c/o Sequenom Instruments GmbH
                                   Mendelssohnstrasse 15 D
                                   D-22761 Hamburg/Germany
                                   Attn.:  Prof.  Dr. Hubert Koester

               with copy to:       Foley, Hoag & Eliot
               ------------        One Post Office Square
                                   Boston, MA 02109/USA
                                   Attn.: David Pearson, Esq.


or such other address as either party hereto shall have designated by notice in
writing to the other party.

          (j)  Attorney's Fees and Costs
               -------------------------
               Should litigation arise concerning the enforcement or
interpretation of this Agreement, the prevailing party shall be entitled to
recover its reasonable attorney's fees and costs as determined by the court.
<PAGE>

     IN WITNESS WHEREOF, the Parties hereto have executed this Agreement on the
date first above written.


SEQUENOM, Inc.                                   CONSULTANT:





By:  /s/  Fareed Kureshy                          /s/    Franz Hillenkamp
   ----------------------------                  -----------------------------
Title: President                                 9/1/96
      -------------------------



                           SEQUENOM Instrument GmbH:



                           By:  /s/  Helmut Shuhsler
                               ------------------------
Title:                         illegible
                               ------------------------


                           Sequenom Instruments GmbH
                             Mendelssohnstr. 15 D
                                 22761 Hamburg
                             Tel. 040 - 89 96 76-0
                             Fax. 040/89 96 76-10
<PAGE>

CONSULTING AGREEMENT
Prof. Dr. F. Hillenkamp /Aug. 1996                                          -6-
- -------------------------------------------------------------------------------
                                   EXHIBIT A
                                   ---------

                                     TERM

The term of the Agreement shall be the period from June 1, 1996 to May 31, 1999,
subject to termination in accordance with Section 5.

                       DESCRIPTION OF SERVICES AND TASKS

The Consultant will:

(1)  provide advice and technical assistance to Sequenom on all aspects of
     ***, including ***

(2)  provide technical advice that will assist Sequenom in ***;

(3)  assist Sequenom in *** and and related technologies, with appropriate
     expertise in instrument design, construction and specific application
     areas;

(4)  make every reasonable effort to attend all meetings of the Scientific
     Advisory Board and participate in all discussions and decisions related to
     strategies, technical approaches and technical progress for the overall
     project;

and, in addition to regular communication with Sequenom personnel via telephone,
fax, courier or normal mail, spend up to two days per month at Sequenom
Instruments GmbH, Hamburg/Germany, or the location of Sequenom, Inc. in the USA.

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission.
<PAGE>

CONSULTING AGREEMENT
Prof. Dr. F. Hillenkamp /Aug. 1996                                          -7-
- -------------------------------------------------------------------------------
                                   EXHIBIT B
                                   ---------
                       COMPENSATION AND PAYMENT SCHEDULE

In return, Sequenom will provide to the Consultant:

(1)  ***

(2)  ***

(3)  ***

(4)  ***

(5)  ***

(6)  ***

     (a)  ***

     (b)  ***

     (c)  ***

(7)  ***

*** Portions of this page have been ommitted pursuant to a request for
Confidential Treatment and filed separately with the commission.
<PAGE>

CONSULTING AGREEMENT
Prof. Dr. F. Hillenkamp /Aug. 1996                                          -8-
- -------------------------------------------------------------------------------
                                   EXHIBIT C
                                   ---------

                           CONFIDENTIALITY AGREEMENT

Under tile terms of tile Consulting Agreement, the Consultant is under
obligation not to disclose any business information or Company secrets to
unauthorized parties and/or to persons outside the Company.

Maintaining confidentiality is a constituent part of the Consultant's loyalty to
the Company and protects business and Company secrets.  Company secrets are data
and materials identified as confidential or those which, upon careful
consideration, a Consultant can recognize as being confidential (e.g. technical
expertise, even if not patentable, supply sources for goods, customer lists,
price schedules, calculations, investment plans, etc., including also the
Consultant's own inventions made in the performance of the Consulting Agreement.

Details of any production or analytical methods of which the Consultant may gain
knowledge and regarding which the Company as license holder is committed to
maintain strictest confidentiality are also classified as secret.  This applies
to details of production processes to which the Company has gained access in the
course of an exchange of know-how with another Company or which are classified
secret by the Company under its commitment to confidentiality with another
Company.

The Consultant further undertakes to maintain strictest confidentiality
regarding all matters of the Company's business also after termination of the
Consulting Agreement.  In this context the Consultant is obliged, if so
required, to sign a respective personal commitment to confidentiality vis-a-vis
third parties.

In the event of any violation of this Agreement to confidentiality, the Company
is entitled to impose a penalty for each violation, without prejudice to the
Company's right to claim for higher damages, or the Company's right to
termination of the Consulting Agreement.

Consultant retains the right to publish results obtained as a result of or in
connection with the services delivered under this Agreement.  Consultant shall
inform Company about intended publications at the earliest convenience and shall
provide Company with all relevant material, in particular draft manuscripts.
Company may delay publication by a maximum of three months if all or part of the
material is deemed to contain patentable material or material which can be
legally protected by other means.  Consultant shall provide Company with all
available material necessary to file for such rights.  In case of other tangible
information, both parties will make every reasonable effort to limit the
published information so as not to interfere with the justified commercial
interest of the Company under the provision that the scientific content of the
publication be retained.


Consultant:                                 /s/  Franz Hillenkamp       9/1/96
                                           -----------------------------------
                                           -----------------------------------
                                           Prof. Dr. Franz Hillenkamp




Sequenom, Inc.:                            /s/        Fareed Kureshy
                                           -----------------------------------
                                           Name   Fareed Kureshy
                                           Title: President
<PAGE>

CONSULTING AGREEMENT
Prof. Dr. F. Hillenkamp /Aug. 1996                                          -9-
- -------------------------------------------------------------------------------

Sequenom Instruments GmbH:                 /s/    Helmut Schuhsler
                                           -----------------------------------
                                           Name:  Dr. Helmut Schuhsler
                                           Title: (Illegible)


                           Sequenom Instruments GmbH
                             Mendelssohnstr. 15 D
                                 22761 Hamburg
                             Tel. 040 - 89 96 76-0
                             Fax. 040/89 96 76-10

<PAGE>

                                                                   EXHIBIT 10.40

                         CONSULTING SERVICES AGREEMENT

     THIS AGREEMENT is entered into this 30th day of January, 1997, by and
between Sequenom, Inc. (the "Company") of San Diego, CA/USA and Sequenom
Instruments GmbH of Hamburg/Germany (the "Company") and Prof.  Dr. Peter
Roepstorff ("Consultant").

     NOW, THEREFORE, it is agreed as follows:

     1.   Definitions
          As used herein:

          (a) The term "Products" shall mean the devices and reagents proposed
to be developed by, or with the assistance of, Consultant hereunder as defined,
and with the specifications set forth in Exhibit A hereto.

          (b) The term "Technology" shall mean the results and product (interim
and/or final) of the consulting services performed by Consultant hereunder,
whether tangible or intangible, including, without limitation, each and every
invention, formula, trade secret, software program (including without
limitation, object code, source code, flow charts, algorithms and related
documentation), listing, routine, manual, specification, technique, product,
concept, know-how, or similar property, whether or not patentable or
copyrightable, and whether or not embodied in any Products that are made,
developed, perfected, designed conceived or first reduced to practice by
Consultant, either solely or jointly with others, in the course and scope of the
consulting services performed hereunder.

     2.   Engagement or Performance of Services

          (a)  Engagement
               ----------
               The Company hereby engages Consultant to be a member of its
Scientific Advisory Board and to perform consulting services in accordance with
the terms and conditions of this Agreement. The specific tasks and services to
be performed by Consultant are set forth in Exhibit A attached hereto. If such
services include the development of specific Products, the specifications of
such Products are set forth in Exhibit A attached hereto.

          (b) Facilities, Equipment and Supplies
              ----------------------------------
              The company will provide to the Consultant the facilities,
equipment and supplies specified in Exhibit A attached hereto. *** It is
understood that milestones cannot be achieved unless funding by either funding
agencies or the Company is available. Consultant shall, at his own cost and
expense, provide all other facilities, equipment and supplies necessary to
perform the consulting services hereunder.

          (c)  Other Services
               --------------
               The Company acknowledges and agrees that, subject to its
obligations hereunder, Consultant shall have the right to engage in researches
and development and

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

CONSULTING AGREEMENT
Prof. Dr. Peter Roepstorff                                                     2
- --------------------------------------------------------------------------------


consulting activities in all areas other than ***. Such activities in the field
of *** are permissible, provided, however, that Consultant shall not perform any
consulting services for an actual or potential competitor of the Company during
the term of this Agreement and for a period of one (1) year after termination of
this Agreement. It is understood that the consulting activities in all areas
other than ***, are non exclusive.

          (d)  Primary Duty
               ------------
               The Company and the Consultant recognize that Consultant's
primary duty as a member of the faculty of Odense University (the "University")
is to the University. The Company and the Consultant agree that the University's
policies and Consultant's obligations to the University shall be observed in the
event a conflict arises with this Agreement. The same applies to funding
agencies who fund Consultant's research through research contracts with the
University of Odense or by funds administered by the University of Odense.

          (e)  Compensation
               ------------
               As compensation for the consulting services provided by
Consultant hereunder, the Company shall pay to Consultant the amounts specified,
at the time(s) specified, on Exhibit B attached hereto.

          (f)  Expenses
               --------
               In addition to the compensation specified in subsection 2(e), the
Company will pay reasonable out-of-pocket expenses incurred by Consultant and
approved in advance by the Company in the furtherance of or in connection with
the performance of consulting services hereunder.

          (g)  No Violation of Others' Rights
               ------------------------------
               Consultant represents and warrants that in the course of
performing services hereunder Consultant will not infringe or wrongfully
appropriate any patents, copyrights, trade secret rights, or other intellectual
property rights of any person or entity anywhere in the world.

     3.   Protection of Confidential Information
          On or before the date hereof, the Company and the Consultant shall
have entered into a separate agreement regarding Consultant's use of
confidential information (attached as Exhibit C).

     4.   Property Rights
          All rights, title and interest in and to the Products (if any) and the
Technology developed under this Agreement shall at all times be and remain the
sole and exclusive property of the Company, and the Products and the Technology
shall be deemed to be works made for hire.  The parties agree that any patents,
trademarks or copyrights that may issue relating to any of the Products or the
Technology shall be in the name of and assigned to the Company.  Patents and
rights resulting from research and development, the results of which are
disclosed to the Company before or at the time of signature of this Agreement
can be licensed and/or sold by Company only with Consultant's written consent.
In case the Company has an interest in

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission.
<PAGE>

CONSULTING AGREEMENT
Prof. Dr. Peter Roepstorff                                                     3
- --------------------------------------------------------------------------------


developing the technology, a license agreement shall be negotiated according to
standard and fair marketing conditions.

     5.   Term and Termination
          The term of this Agreement shall be as set forth in Exhibit A attached
hereto.  Unless otherwise specified in Exhibit A, either party may terminate
this Agreement at any time upon thirty days written notice delivered to the
other.  The provision of Sections 3 and 4 hereof shall survive the termination
of this Agreement.

     6.   Miscellaneous

          (a)  Use of University's Name
               ------------------------
               With the limited exception of citing Consultant's faculty title,
the Company and its affiliates will not use the names, likeness, or logos of the
University, any of its schools or divisions in any of their fund raising or in
investment documents, general publications, advertisements, or marketing and
promotional materials without the prior written permission of the University.

          (b)  Relationship of Parties
               -----------------------
               Consultant shall at all times during the performance of his
services hereunder be an independent contractor, maintaining sole and exclusive
control over its business and operations. At no time will either party hold
itself out to be the agent, employee, lessee, sublessee, partner or joint
venturer of the other party. Neither party hereto shall have the express or
implied right or authority to assume or create any obligation on behalf of or in
the name of the other party, or to bind the other party in regard to any
contract, agreement or undertaking with any third party.

          (c)  Entire Agreement
               ----------------
               This Agreement, together with the exhibits attached hereto,
constitutes the entire agreement between the parties relating to the subject
matter hereof and supersedes all prior written or oral negotiations,
representations or agreements.  No modification of this Agreement shall be
binding on either party unless it is in writing and signed by both parties.

          (d)  Severability
               ------------
               The provisions of this Agreement are severable, and if one or
more provisions are judicially determined to be illegal or otherwise
unenforceable, in whole or in part, the remaining provisions or portions of this
Agreement shall nevertheless be binding on and enforceable by and between the
parties hereto.

          (e)  Assignment
               ----------
               This Agreement shall insure to the benefit or and be binding upon
the successors and assigns of the parties hereto; provided, however, that
Consultant shall not transfer or assign this Agreement without the prior written
consent of the Company.

          (f)  Governing Law
               -------------
               The rights and obligations of the parties to this Agreement shall
be governed by and construed in accordance with the laws of the Commonwealth of
Massachusetts.
<PAGE>

CONSULTING AGREEMENT
Prof. Dr. Peter Roepstorff                                                     4
- --------------------------------------------------------------------------------

          (g)  Headings
               --------
               Section headings are for convenience of reference only and shall
not be considered in the interpretation of this Agreement.

          (h)  Unavoidable Delays
               ------------------
               Either party shall be excused for any delays or defaults in the
performance of this Agreement (except the payment of amounts due and payable
hereunder) unavoidably caused by the act of the other, the act of any agent of
the other, the act of any governmental authority, acts of God, the elements,
war, litigation, strikes, walkouts, or any other cause beyond its reasonable
control.  Each party shall use all reasonable diligence to avoid any such delay
or default and to resume performance under this Agreement as soon as practicable
after such delay or default.

          (i)  Notices
               -------
               All notices, requests, demands and other communications to be
given pursuant to this Agreement shall be in writing and shall be deemed to have
been duly given if delivered by hand or mailed by registered or certified mail,
return receipt requested, postage prepaid, or by facsimile transmission if a
true and correct copy is sent the same day by first class mail, postage prepaid,
or by dispatch by in internationally recognized express courier service, and in
each case addressed as follows:

     If to Consultant:   Prof.  Dr. Peter Roepstorff
     ----------------    Kolding Landevej 43
                         DK-7000 Fredericia/Denmark

     If to the Company:  Sequenom, Inc.
     -----------------   c/o Sequenom Instruments GmbH
                         Mendelssohnstrasse 15 D
                         D-22761 Hamburg/Germany
                         Attn.: Prof. Dr. Hubert Koster

     with copy to:       Foley, Hoag & Eliot
                         One Post Office Square
                         Boston, MA  02109/USA
                         Attn.: David Pearson, Esq.

or such other address as either party hereto shall have designated by notice in
writing to the other a party.

          (j)  Attorney's fees and Costs
               -------------------------
               Should litigation arise concerning the enforcement or
interpretation of this Agreement, the prevailing party shall be entitled to
recover its reasonable attorney's fees and costs as determined by the court.
<PAGE>

CONSULTING AGREEMENT
Prof. Dr. Peter Roepstorff                                                     5
- --------------------------------------------------------------------------------

     IN WITNESS WHEREOF, the Parties hereto have executed this Agreement on the
date first above written.

SEQUENOM, Inc.                        CONSULTANT:

By: /s/   illegible                   /s/ illegible
    -------------------------         ----------------------------

Title: CTO
       ----------------------


                            SEQUENOM Instruments GmbH:

                            By:  /s/ illegible
                                 -------------------------

                            Title:  illegible
                                    ----------------------
<PAGE>

CONSULTING AGREEMENT
Prof. Dr. Peter Roepstorff                                                     6
- --------------------------------------------------------------------------------


                                   EXHIBIT A
                                   ---------

                                     TERM

The term of the Agreement shall be the period from March 1, 1997 to February 28,
2000, subject to termination in accordance with Section 5.

                       DESCRIPTION OF SERVICES AND TASKS

The Consultant will:

(1)  be a member of the Sequenom Scientific Advisory Board;

(2)  provide advice and technical assistance to Sequenom on all aspects of ***
     and proteins, including applications in the area of ***.

(3)  provide technical advice, in particular also with reference to ***

(4)  assist Sequenom in *** and related technologies, with appropriate expertise
     in applications of ***

(5)  make every reasonable effort to attend all meetings of the Scientific
     Advisory Board and participate in all discussions and decisions related to
     strategies, technical approaches and technical progress for the overall
     project;

and, in addition to regular communication with Sequenom personnel via telephone,
fax, courier or normal mail, spend up to one day per month at Sequenom
Instruments GmbH, Hamburg/Germany, or the location of Sequenom, Inc. in the USA.

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission.
<PAGE>

CONSULTING AGREEMENT
Prof. Dr. Peter Roepstorff                                                     7
- --------------------------------------------------------------------------------

                                   EXHIBIT B
                                   ---------

                       COMPENSATION AND PAYMENT SCHEDULE

In return, Sequenom will provide to the Consultant:

(1)  ***

(2)  ***

(3)  ***

(4)  ***

(5)  ***

(6)  ***

     (a)
     (b)  to be defined
     (c)

(7)  ***

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission.
<PAGE>

CONSULTING AGREEMENT
Prof. Dr. Peter Roepstorff                                                     8
- --------------------------------------------------------------------------------

                                   EXHIBIT C
                                   ---------

                           CONFIDENTIALITY AGREEMENT

Under the terms of the Consulting Agreement, the Consultant is under obligation
not to disclose any business information or company secrets to unauthorized
parties and/or to persons outside the Company.

Maintaining confidentiality is a constituent part of the Consultant's loyalty to
the Company and protects business and company secrets.  Company secrets are data
and materials identified as confidential or those which, upon careful
consideration, a Consultant can recognize as being confidential (e.g. technical
expertise, even if not patentable, supply sources for goods, customer lists,
price schedules, calculations, investment plans, etc., including also the
Consultant's own inventions made in the performance of the Consulting Agreement.
This agreement to confidentiality is deemed to extend and apply also to any co-
workers involved in the execution of the collaboration project with the Company.

Details of any production or analytical methods of which the Consultant may gain
knowledge and regarding which the Company as license holder is committed to
maintain strictest confidentiality are also classified as secret.  This applies
to details of production processes to which the Company has gained access in the
course of an exchange of know-how with another company or which are classified
secret by the Company under its commitment to confidentiality with another
company.

The Consultant further undertakes to maintain strictest confidentiality
regarding all matters of the Company's business also after termination of the
Consulting Agreement.  In this context the Consultant is obliged, if so
required, to sign a respective personal commitment to confidentiality vis-a-vis
third parties.

In the event of any violation of this agreement to confidentiality, the Company
is entitled to impose a penalty for each violation, without prejudice to the
Company's right to claim for higher damages, or the Company's right to
termination of the Consulting Agreement.

Consultant:                                    /s/ Prof. Dr. Peter Reopstorff
                                               ------------------------------
                                                   Prof. Dr. Peter Roepstorff

SEQUENOM, Inc.                                 /s/  Dr. Hubert Koster
                                               ------------------------------
                                                   Name:  Dr. Hubert Koster
                                                   Title:  CTO

SEQUENOM Instruments GmbH:                     /s/ illegilbe
                                               ------------------------------
                                                   Name:  illegible
                                                   Title: illegible

<PAGE>

                                                                   EXHIBIT 10.41


                         CONSULTING SERVICES AGREEMENT
                         -----------------------------

     THIS AGREEMENT is entered into this  17th  day of  February, 1997, by and
                                         ------        ---------
between Sequenom, Inc. (the "Company") and Prof. Dr.med.Dr.rer.nat Ulf.B.
Gobel ("Consultant").

     NOW, THEREFORE, it is agreed as follows:

     1.  Definitions.
     2.  As used herein:

         (a)  The term "Products" shall mean the devices, reagents, kits and
diagnostic assays and services proposed to be developed by, or with the
assistance of, Consultant hereunder as defined, and with the specifications set
forth in Exhibit A hereto.
         ---------

         (b)  The term "Technology" shall mean the results and product (interim
and/or final) of the consulting services performed by Consultant hereunder,
whether tangible or intangible, including, without limitations each and every
invention, formula, trade secret, software program (including without
limitation, object code, source code, flow charts, algorithms and related
documentation), listing, routine, manual, specification, technique, product,
concept, know-how, or similar property, whether or not patentable or
copyrightable, and whether or not embodied in any Products that are made,
developed, perfected, designed conceived or first reduced to practice by
Consultant, either solely or jointly with others, in the course and scope of the
consulting services performed hereunder.

       2. Engagement or Performance of Services.

          (a)  Engagement.
               ----------

               The Company hereby engages Consultant to perform consulting
services in accordance with the terms and conditions of this Agreement. The
specific tasks and services to be performed by Consultant are set forth in
Exhibit A attached hereto.  If such services include the development of specific
- ---------
Products, the specifications of such Products are set forth in Exhibit A
                                                               ---------
attached hereto.


          (b)  Facilities, Equipment and Supplies.
               ----------------------------------

               The Company will provide to the Consultant the facilities,
equipment and supplies specified in Exhibit A attached hereto. Consultant shall
                                    ---------
to some extent, at his own cost and expense, provide all other facilities,
equipment and supplies necessary to perform the consulting services hereunder.
***

          (c)  Other Services.
               --------------

               The Company acknowledges and agrees that, subject to its
obligations hereunder, Consultant shall have the right to engage in researches
and development and consulting activities for himself and others during the term
of this Agreement; provided, however, that Consultant shall not perform any
consulting services for an actual or potential competitor of the Company during
the term of this Agreement and for a period of one (1) year after termination of
this Agreement.

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission.
<PAGE>

Consulting Services Agreement
Prof. Dr. U.B. Gobel, Berlin                                                 -2-
- --------------------------------------------------------------------------------

          (d)  Primary Duty.
               ------------

               The Company and the Consultant recognize that Consultant's
primary duty as a member of the Charite University Clinic of Berlin (the
"University") is to the University. The Company and the Consultant agree that
the University's policies and Consultant's obligations to the University shall
be observed in the event a conflict arises with this Agreement.

          (e)  Compensation.
               ------------

               As compensation for the consulting services provided by
Consultant hereunder, the Company shall pay to Consultant the amounts specified,
at the time(s) specified on Exhibit B attached hereto.

          (f)  Expenses.
               --------

               In addition to the compensation specified in subsection 2(e), the
Company will pay reasonable out-of-pocket expenses incurred by Consultant and
approved in advance by the Company in the furtherance of or in connection with
the performance of consulting services hereunder.

          (g)  No Violation of Others' Rights.
               ------------------------------

               Consultant represents and warrants that in the course of
performing services hereunder Consultant will not infringe or wrongfully
appropriate any patents, copyrights, trade secret rights, or other intellectual
property rights of any person or entity anywhere in the world.

     3.   Protection of Confidential Information.

          On or before the date hereof, the Company and the Consultant shall
have entered into a separate agreement regarding Consultant's use of
confidential information (attached as Exhibit C).
                                      ---------

     4.   Property Rights.

          All rights, title and interest in and to the Products (if any) and the
Technology shall at all times be and remain the sole and exclusive property of
the Company, and the Products and the Technology shall be deemed to works make
for hire.  The parties agree that any patents, trademarks or copyrights that may
issue relating to any of the Products or the Technology shall be in the name of
and assigned to the Company.  In the event of successful commercialization of
patented technology generated through the participation of Consultant, a license
agreement will be negotiated in good faith, reflecting the extent of
Consultant's participation and the Company's financial contributions as well as
related innovations created by Company personnel in the course of the
development.

          Publication or presentation of results generated during the
performance of Consultant's services is desired.  However, such publication or
presentation is subject to Company's prior approval which shall not be
unreasonably withheld.  However, a period of 60 days is anticipated for
clearance of Consultant's request for publication and/or presentation of results
in order to determine whether parts of such scientific results are patentable or
would disclose trade secrets in which case those parts of the results should be
omitted from the publication and/or presentation.
<PAGE>

Consulting Services Agreement
Prof. Dr. U.B. Gobel, Berlin                                                 -3-
- --------------------------------------------------------------------------------

5.        Term and Termination.

          The term of this Agreement shall be as set forth in Exhibit A attached
hereto.  Unless otherwise specified in Exhibit A, either party may terminate
this Agreement at any time upon thirty ( 30) days written notice delivered to
the other.  The provision of Sections 3 and 4 hereof shall survive the
termination of this Agreement.

6.        Miscellaneous.

          (a)  Use of University's Name.
               ------------------------
               With the limited exception of citing Consultant's faculty title,
the Company and its affiliates will not use the names, likeness, or logos of the
University, any of its schools or divisions in any of their fund raising or in
investment documents, general publications, advertisements, or marketing and
promotional materials without the prior written permission of the University.

          (b)  Relationship of Parties.
               -----------------------
               Consultant shall at all times during the performance of his
services hereunder be an independent contractor, maintaining sole and exclusive
control over its business and operations. At no time will either party hold
itself out to be the agent, employee, lessee, sublessee, partner or joint
venturer of the other party. Neither party hereto shall have the express or
implied right or authority to assume or create any obligation on behalf of or in
the name of the other party, or to bind the other party in regard to any
contract, agreement or undertaking with any third party.

          (c)  Entire Agreement.
               ----------------
               This Agreement, together with the exhibits attached hereto,
constitutes the entire agreement between the parties relating to the subject
matter hereof and supersedes all prior written or oral negotiations,
representations or agreements.  No modification of this Agreement shall be
binding on either party unless it is in writing and signed by both parties.

          (d)  Severability.
               ------------
               The provisions of this Agreement are severable, and if one or
more provisions are judicially determined to be illegal or otherwise
unenforceable, in whole or in part, the remaining provisions or portions of this
Agreement shall nevertheless be binding on and enforceable by and between the
parties hereto.

          (e)  Assignment.
               ----------
               This Agreement shall insure to the benefit or and be binding upon
the successors and assigns of the parties hereto; provided, however, that
Consultant shall not transfer or assign this Agreement without the prior written
consent of the Company.

          (f)  Government Law.
               --------------
               The rights and obligations of the parties to this Agreement shall
be governed by and construed in accordance with the laws of the State of
California.

          (g)  Headings.
               --------
               Section headings are for convenience of reference only and shall
not be considered in the interpretation of this Agreement.
<PAGE>

Consulting Services Agreement
Prof. Dr. U.B. Gobel, Berlin                                                 -4-
- --------------------------------------------------------------------------------

     (h)  Unavoidable Delays
          ------------------

          Either party shall be excused for any delays or defaults in the
performance of this Agreement (except the payment of amounts due and payable
hereunder) unavoidably caused of God, the elements, war, litigation, strikes,
walkouts, or any other cause beyond its reasonable control.  Each party shall
use all reasonable diligence to avoid any such delay or default and to resume
performance under this Agreement as soon as practicable after such delay or
default.

     (i)  Notices.
          -------

          All notices, requests, demands and other communications to be given
pursuant to this Agreement shall be in writing and shall be deemed to have been
duly given if delivered by hand or mailed by registered or certified mail,
return receipt requested, postage prepaid, or by facsimile transmission if a
true and correct copy is sent the same day by first class mail, postage prepaid,
or by dispatch by in internationally recognized express courier service, and in
each case addressed as follows:

     If to Consultant:   Prof Dr. Dr. Ulf B. Gobel
                         Universit@tsklinikum CHARIT
                         Dorotheenstr. 96/Wilhelmstr. 67
                         D-10117 Berlin

     If to the Company:  Sequenom, Inc.
                         c/o Sequenom Instruments GmbH
                         Mendelssohnstrasse 15 D
                         D-22761 Hamburg / Germany
                         Attn.:  Prof.  Dr. Hubert Kster

     with copy to:       Foley, Hoag & Eliot
                         One Post Office Square
                         Boston, MA 02109 / USA
                         Attn.: David Pearson, Esq.

or such other address as either party hereto shall have designated by notice in
writing to the other party.

     (j)  Attorney's Fees and Costs
          -------------------------

          Should litigation arise concerning the enforcement or interpretation
of this Agreement, the prevailing party shall be entitled to recover its
reasonable attorney's fees and costs as determined by the Court.
<PAGE>

Consulting Services Agreement
Prof. Dr. U.B. Gobel, Berlin                                                 -5-
- --------------------------------------------------------------------------------


     IN WITNESS WHEREOF, the Parties hereto have executed this Agreement on the
date first above written.


SEQUENOM, Inc.                                     CONSULTANT:

By:   /s/ H. Koster                                /s/ Ulf B. Gobel
     ----------------------------                  -----------------------------
Name:  Dr. H. Koster                               Dr. Dr. Ulf B Gobel
Title:  CEO
<PAGE>

Consulting Services Agreement
Prof. Dr. U.B. Gobel, Berlin                                                 -6-
- --------------------------------------------------------------------------------

                                   EXHIBIT A
                                   ---------

                                     TERM

The term of the Agreement shall be the period from June 1, 1996 to May 31, 1999,
subject to termination in accordance with Section 5.

                       DESCRIPTION OF SERVICES AND TASKS

The Consultant will:

(1)  provide advice and technical assistance to Sequenom on all aspects of
     clinical microbiology, including but not limited to ***;

(2)  provide technical advice that will assist Sequenom ***;

(3)  assist Sequenom *** clinical microbiology ***, with expertise in molecular
     clinical microbiology and related state-of-the-art technologies;

(4)  attend meetings of the Scientific Advisory Board and participate in all
     discussions and decisions related to strategies, technical approaches and
     technical progress for the overall project;

(5)  and, all addition to regular communication with Sequenom personnel via
     telephone, fax, courier or normal mail, spend up to two days per month at
     Sequenom Instruments GmbH, Hamburg/Germany, or the location of Sequenom,
     Inc. in the USA.


     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.

<PAGE>

Consulting Services Agreement
Prof. Dr. U.B. Gobel, Berlin                                                 -7-
- --------------------------------------------------------------------------------

                                   EXHIBIT B
                                   ---------

                       COMPENSATION AND PAYMENT SCHEDULE

In return, Sequenom will provide to the Consultant:

(1)  ***

(2)  ***

(3)  ***

(4)  ***

(5)  ***

(6)  ***

     (a)
     (b)                 TO BE DEFINED
     (c)

(7)  ***

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission.
<PAGE>

Consulting Services Agreement
Prof. Dr. U.B. Gobel, Berlin                                                 -8-
- --------------------------------------------------------------------------------

                                   EXHIBIT C
                                   ---------
                           CONFIDENTIALITY AGREEMENT

Under the terms of the Consulting Agreement, the Consultant is under obligation
not to disclose any business information or company secrets to unauthorized
parties and/or to persons outside the Company.

Maintaining confidentiality is a constituent part of the Consultant's loyalty to
the Company and protects business and company secrets.  Company secrets are data
and materials identified as confidential or those which, upon careful
consideration, a Consultant can recognize as being confidential (e.g. technical
expertise, even if not patentable, supply sources for goods, customer lists,
price schedules, calculations, investment plans, etc., including also the
Consultant's own inventions made in the performance of the Consulting Agreement.

Details of any production or analytical methods of which the Consultant may gain
knowledge and regarding which the Company as license holder is committed to
maintain strictest confidentiality are also classified as secret.  This applies
to details of production processes to which the Company has gained access in the
course of an exchange of know-how with another company or which are classified
secret b the Company under its commitment to confidentiality with another
company.

The Consultant further undertakes to maintain strictest confidentiality
regarding all matters of the Company's business also after termination of the
Consulting Agreement.  In this context the Consultant is obliged, if so
required, to sign a respective personal commitment to confidentiality vis--vis
third parties.

In the event of any violation of this agreement to confidentiality, the Company
is entitled to impose a penalty for each violation, without prejudice to the
Company's right to claim for higher damages, or the Company's right to
termination of the Consulting Agreement.

Consultant:                           SEQUENOM:

/s/ Dr. Ulf B.Gobel                   /s/ illegible
- -----------------------               ----------------------
Dr. Dr. Ulf B Gobel                   Name/Title

Date:  12/22/1996                     Date:  2/18/97
       ----------------                     ----------------

<PAGE>

                                                                 EXHIBIT 10.42


                         CONSULTING SERVICES AGREEMENT

    THIS AGREEMENT is entered into this 1st day of March 1999, by and between
Sequenom, Inc. (the "Company") and Dr. John Cashman ("Consultant").

    NOW, THEREFORE, it is agreed as follows:

    1.   Definitions: As used herein:
         -----------

         (a)  The term "Products" shall mean the devices, if any, proposed to be
              developed by, or with the assistance of, Consultant hereunder as
              defined, and with the specifications set forth in Exhibit hereto.

         (b)  The term "Technology" shall mean the results and product (interim
              and/or final) of the consulting services performed by Consultant
              hereunder, whether tangible or intangible, including, without
              limitation, each and every invention, formula, trade secret,
              software program (including without limitation, object code,
              source code, flow charts, algorithms and related documentation),
              listing, routine, manual, specification, technique, product,
              concept, know-how, or similar property, whether or not patentable
              or copyrightable and whether or not embodied in any Products, that
              are made, developed, perfected, designed, conceived or first
              reduced to practice by Consultant, either solely or jointly with
              others, in the course and scope of the consulting services
              performed hereunder. Technology will exclude results and or
              products developed in conjunction with co-sponsored Federal or
              other grants.

    2.   Engagement and Performance of Services
         --------------------------------------

         (a)  Engagement.  The Company hereby engages Consultant to perform
              ----------
              consulting services in accordance with the terms and conditions
              of this agreement.  The specific task and services to be
              performed by Consultant are set forth on Exhibit A attached
              hereto.  If such services include the development of specific
              Products, the specifications of such Products are as set forth on
              Exhibit A attached hereto.

         (b)  Facilities, Equipment and Supplies. The Consultant shall provide,
              ----------------------------------
              at his own cost, supplies necessary to perform the consulting
              services hereunder.

         (c)  Other Services.  The Company acknowledges and agrees that,
              --------------
              subject to its obligations hereunder, Consultant shall have the
              right to engage in research and development and consulting
              activities for himself and others during the term of this
              Agreement; provided, however, that Consultant shall not perform
              any consulting services for an actual or potential competitor of
              the Company involved in *** as a primary service or product during
              the term of this agreement.

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission.
<PAGE>

         (d)  Duration of Services.  The Company and the Consultant recognize
              --------------------
              that duration of services will not exceed one (1) year.

         (e)  Compensation.  As compensation for the consulting services
              ------------
              provided by Consultant hereunder, the Company shall pay to
              Consultant *** with the first installment beginning on March 1,
              1999. In addition, the Consultant will receive ***.

         (f)  Expenses.  In addition to the compensation specified in
              --------
              subsection (e), the Company will pay reasonable expenses incurred
              by Consultant and approved in advance by the Company in the
                                ----------------------------------
              furtherance of or in connection with the performance of
              consulting services hereunder.  These expenses include but are
              not limited to ***.

         (g)  No Violation of Other's Rights.  Consultant represents and
              ------------------------------
              warrants that in the course of performing services hereunder
              Consultant will not infringe or wrongly appropriate any patents,
              copyrights, trade secret rights, or other intellectual property
              rights of any person or entity anywhere in the world.

    3.   Protection of Confidential Information.  On or before the date hereof,
         --------------------------------------
         the Company and the Consultant shall have entered into a separate
         agreement regarding Consultant's use of confidential information.

    4.   Property Rights.  All right, title and interest in and to the Products
         ---------------
         (if any) and the Technology shall at all times be and remain the sole
         and exclusive property of the Company, and the Products and the
         Technology shall be deemed to be works made for hire.  The parties
         agree that any patents, trademarks or copyrights that may issue
         relating to any of the Products or the Technology shall be in the name
         of and assigned to the Company.

    5.   Term and Termination.  The terms of this agreement may be terminated
         --------------------
         only by written notice at any time.  The provisions of Sections 3 and
         4 hereof shall survive the termination of this Agreement.

    6.   Miscellaneous.
         -------------

         (a)  Relationships of Parties.  Consultant shall at all time during
              ------------------------
              the performance of his services hereunder be an independent
              contractor, maintaining sole and exclusive control over its
              business and operations.  At no time will either party hold
              itself out to be the agent, employee, lessee, sublessee, partner
              or joint venturer of the other party.  Neither party hereto shall
              have the express or implied right or authority to assume or

*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission.

                                       2
<PAGE>

              create any obligation on behalf of or in the name of the other
              party, or to bind the other party in regard to any contract,
              agreement or undertaking with any third party with the exception
              of mutually agreed upon Federal and other grants.

         (b)  Entire Agreement.  This Agreement, together with the exhibits
              ----------------
              attached hereto, constitutes the entire agreement between the
              parties relating to the subject matter hereof and supersedes all
              prior written or oral negotiations, representations or
              agreements.  No modification of this Agreement shall be binding
              on either party unless it is in writing and signed by both
              parties.

         (c)  Severability.  The provisions of this Agreement are severable,
              ------------
              and if one or more provisions are judicially determined to be
              illegal or otherwise unenforceable, in whole or in part, the
              remaining provisions or portions of this Agreement shall
              nevertheless be binding on and enforceable by and between the
              parties hereto.

         (d)  Assignment.  This Agreement shall inure to the benefit of and be
              ----------
              binding upon the successors and assigns the parties hereto;
              provided, however, that Consultant shall not transfer or assign
              this Agreement without the prior written consent of the Company.

         (e)  Governing Law.  The rights and obligations of the parties to this
              -------------
              agreement shall be governed by and construed in accordance with
              the laws of California.

         (f)  Headings.  Section headings are for convenience of reference only
              --------
              and shall not be considered in the interpretation of this
              Agreement.

         (g)  Unavoidable Delays.  Either party shall be excused for any delays
              ------------------
              or defaults in the performance of this Agreement (except the
              payment of amounts due and payable hereunder) unavoidably caused
              by the act of the other, the act of any agent of the other, the
              act of any governmental authority, acts of God, the elements,
              war, litigation, strikes, walkouts, or any other cause beyond
              reasonable control.  Each party shall use all reasonable
              diligence to avoid any such delay or default and to resume
              performance under this Agreement as soon as practicable after
              such delay or default.

         (h)  Notices.  All notices, requests, demands and other communications
              -------
              to be given pursuant to this Agreement shall be in writing and
              shall be deemed to have been duly given if delivered by hand or
              mailed by registered or certified mail, return receipt same day
              by First Class mail, postage prepaid, or by dispatch by an
              internationally recognized express courier service, and in each
              case addressed as follows:

                                       3
<PAGE>

              If to Consultant:  Dr. John Cashman
              ----------------   Director
                                 Human Biomolecular Research Institute
                                 5310 Eastgate Mall
                                 San Diego, CA 92121
              If to the Company: Sequenom, Inc.
              -----------------  11555 Sorrento Valley Road
                                 San Diego, CA 92121
                                 Attn:  Dr. Andi
                                 Vice President, Genomics

              or such other address as either party hereto shall have designated
              by notice in writing to the other party.

         (i)  Attorneys' Fees and Costs. Should litigation arise concerning
              --------------------------
              the enforcement or interpretation of this Agreement, the
              prevailing party shall be entitled to recover its reasonable
              attorney's fees and costs as determined by the court.

         IN WITNESS WHEREOF, the Parties hereto have executed this Agreement on
         the date first above written.

SEQUENOM, INC.                                   CONSULTANT:
By: /s/ A. Braun                                 /s/  John Cashman
    --------------------------                   ---------------------------
    Date: 5-20-99                                May 20, 1999
    Dr. Andi Braun, VP Genomics                  Dr. John Cashman

                                       4
<PAGE>

                                   EXHIBIT A
                                   ---------

The term of the Agreement shall be the period from March 1, 1999 to February 28,
2000, subject to termination in accordance with Section 5.

                       DESCRIPTION OF SERVICES AND TASKS

The consultant will:

1.  Provide advice and technical assistance to Sequenom on ***

2.  Provide ***

3.  Setup of ***

4.  Publish together with Sequenom data from scientists' application of DNA Mass
    Array.

*** Portions of this page have been omitted pursuant to a request for
confidential treatment and filed separately with the commission.

<PAGE>

<TABLE>
<CAPTION>
<S>                                                <C>                           <C>
        SEQUENOM, INC.                             SEQUENOM                          Sequenom GmbH
  11555 Sorrento Valley Road                         LOGO                        Mendelssohnstrasse 15 D
San Diego, CA  92121-1331 USA                                                    D-22761 Hamburg Germany
    Tel. +1-619-350-0345                                                           Tel. +49-40-899676-0
    Fax. +1-619-350-0344                                                          Fax. +49-40-899676-10
      www.sequenom.com                                                              www.sequenom.com
</TABLE>
                                                                   EXHIBIT 10.43



                         CONSULTING SERVICES AGREEMENT

     THIS AGREEMENT is entered into this first day of March, by and between
Sequenom, Inc. (the "Company") and Dr. Lindsay Farrer ("Consultant").

     NOW, THEREFORE, it is agreed as follows:

     1.  Definitions:  As used herein:
         -----------

         (a) The term "Products" shall mean the devices, if any, proposed to be
         developed by, or with the assistance of, Consultant hereunder as
         defined, and with the specifications set forth in Exhibit hereto.

         (b) The term "Technology" shall mean the results and product (interim
         and/or final) of the consulting services performed by Consultant
         hereunder, whether tangible or intangible, including, without
         limitation, each and every invention, formula, trade secret, software
         program (including without limitation, object code, source code, flow
         charts, algorithms and related documentation), listing, routine,
         manual, specification, technique, product, concept, know-how, or
         similar property, whether or not patentable or copyrightable and
         whether or not embodied in any Products, that are made, developed,
         perfected, designed, conceived or first reduced to practice by
         Consultant, either solely or jointly with others, in the course and
         scope of the consulting services performed hereunder.

     2.  Engagement and Performance of Services
         --------------------------------------

         (a)  Engagement.  The Company hereby engages Consultant to perform
              ----------
              consulting services in accordance with the terms and conditions of
              this agreement. The specific task and services to be performed by
              Consultant are set forth on Exhibit A attached hereto. If such
              services include the development of specific Products, the
              specifications of such Products are as set forth on Exhibit A
              attached hereto.

         (b)  Facilities, Equipment and Supplies. The Consultant shall provide,
              ----------------------------------
              at his own cost, supplies necessary to perform the consulting
              services hereunder.

         (c)  Other Services.  The Company acknowledges and agrees that,
              --------------
              subject to its obligations hereunder, Consultant shall have the
              right to engage in research and development and consulting
              activities for himself and others during the term of this
              Agreement; provided, however, that Consultant
<PAGE>

              shall not perform any consulting services for an actual or
              potential competitor of the Company during the term of this
              agreement.

         (d)  Duration of Services.  The Company and the Consultant recognize
              --------------------
              that duration of services will not exceed one (1) year.

         (e)  Compensation.  As compensation for the consulting services
              ------------
              provided by Consultant hereunder, the Company shall pay to
              Consultant *** agreement that the project must not exceed ***. In
              addition Consultant will receive ***.


         (f)  Expenses.  In addition to the compensation specified in
              --------
              subsection 2 (d), the Company will pay reasonable out of pocket
              expenses incurred by Consultant and approved in advance by the
              Company in the furtherance of or in connection with the
              performance of consulting services hereunder.

         (g)  No Violation of Other's Rights.  Consultant represents and
              ------------------------------
              warrants that in the course of performing services hereunder
              Consultant will not infringe or wrongly appropriate any patents,
              copyrights, trade secret rights, or other intellectual property
              rights of any person or entity anywhere in the world.

     3.   Protection of Confidential Information.  On or before the date hereof,
          --------------------------------------
          the Company and the Consultant shall have entered into a separate
          agreement regarding Consultant's use of confidential information.

     4.   Property Rights.  All right, title and interest in and to the Products
          ---------------
          (if any) and the Technology shall at all times be and remain the sole
          and exclusive property of the Company, and the Products and the
          Technology shall be deemed to be works made for hire.  The parties
          agree that any patents, trademarks or copyrights that may issue
          relating to any of the Products or the Technology shall be in the name
          of and assigned to the Company.  If the Consultant is acting on the
          behalf of his employer then any Agreement between the employer and
          Company shall take precedence.

     5.   Term and Termination.  The terms of this agreement may be terminated
          --------------------
          at any time.  The provisions of Sections 3 and 4 hereof shall survive
          the termination of this Agreement.

     6.  Miscellaneous.
         -------------

         (a)  Relationships of Parties.  Consultant shall at all time during
              ------------------------
              the performance of his services hereunder be an independent
              contractor, maintaining sole and exclusive control over its
              business and operations. At no time will either party hold itself
              out to be the agent, employee, lessee, sublessee, partner or joint
              venturer of the other party. Neither party hereto shall have the
              express or implied right or authority to assume or

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission.

                                       2
<PAGE>

              create any obligation on behalf of or in the name of the other
              party, or to bind the other party in regard to any contract,
              agreement or undertaking with any third party.

         (b)  Entire Agreement.  This Agreement, together with the exhibits
              ----------------
              attached hereto, constitutes the entire agreement between the
              parties relating to the subject matter hereof and supersedes all
              prior written or oral negotiations, representations or agreements.
              No modification of this Agreement shall be binding on either party
              unless it is in writing and signed by both parties.

         (c)  Severability.  The provisions of this Agreement are severable,
              ------------
              and if one or more provisions are judicially determined to be
              illegal or otherwise unenforceable, in whole or in part, the
              remaining provisions or portions of this Agreement shall
              nevertheless be binding on and enforceable by and between the
              parties hereto.

         (d)  Assignment.  This Agreement shall inure to the benefit of and be
              ----------
              binding upon the successors and assigns the parties hereto;
              provided, however, that Consultant shall not transfer or assign
              this Agreement without the prior written consent of the Company.

         (e)  Governing Law. The rights and obligations of the parties to this
              -------------
              agreement shall be governed by and construed in accordance with
              the laws of California.

         (f)  Headings.  Section headings are for convenience of reference only
              --------
              and shall not be considered in the interpretation of this
              Agreement.

         (g)  Unavoidable Delays.  Either party shall be excused for any delays
              ------------------
              or defaults in the performance of this Agreement (except the
              payment of amounts due and payable hereunder) unavoidably caused
              by the act of the other, the act of any agent of the other, the
              act of any governmental authority, acts of God, the elements, war,
              litigation, strikes, walkouts, or any other cause beyond
              reasonable control. Each party shall use all reasonable diligence
              to avoid any such delay or default and to resume performance under
              this Agreement as soon as practicable after such delay or default.

         (h)  Notices.  All notices, requests, demands and other communications
              -------
              to be given pursuant to this Agreement shall be in writing and
              shall be deemed to have been duly given if delivered by hand or
              mailed by registered or certified mail, return receipt same day by
              First Class mail, postage prepaid, or by dispatch by an
              internationally recognized express courier service, and in each
              case addressed as follows:

          If to Consultant:     Dr. Lindsay Farrer
          ----------------      Chief, Genetics Program

                                       3
<PAGE>

                                Boston University School Of Medicine
                                715 Albany Street
                                Boston, MA 02118

          If to the Company:    Sequenom, Inc.
          -----------------     11555 Sorrento Valley Road
                                San Diego, CA 92121
                                Attn:  Dr. Andi Braun
                                VP R&D - Medical Applications

          or such other address as either party hereto shall have designated by
          notice in writing to the other party.

          (i)  Attorneys' Fees and Costs.  Should litigation arise concerning
               -------------------------
               the enforcement or interpretation of this Agreement, the
               prevailing party shall be entitled to recover its reasonable
               attorney's fees and costs as determined by the court.

          IN WITNESS WHEREOF, the Parties hereto have executed this Agreement on
          the date first above written.


SEQUENOM, INC.                             CONSULTANT:

By:   /s/ A. Braun                         /s/ Lindsay Farrer
   ----------------------------            ----------------------
Title:  VP R&D-Med Appl.                   Dr. Lindsay Farrer
      -------------------------

                                       4
<PAGE>

                                   EXHIBIT A
                                   ---------

The term of the Agreement shall be the period from March 1, 1999 to February 28,
2000, subject to termination in accordance with section 5.

                       DESCRIPTION OF SERVICES AND TASKS

The consultant will:

1.   Provide advice and technical assistance to Sequenom on *** San Diego,
     including *** for computing.

2.   Provide supervision of ***.

3.   Assist in *** projects conducted within Sequenom but also together with
     third parties. If the Consultant is acting on the behalf of his employer
     then any Agreement between the employer and Sequenom shall take precedence.

4.   Make every reasonable effort to regular communications with Sequenom
     personnel via phone, fax, courier, or normal mail and spend up to three
     times for at least 2 days in Sequenom San Diego.

     *** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the commission.

<PAGE>

                                                                   EXHIBIT 10.45

                   MASTER EQUIPMENT LEASE AGREEMENT NO. 0135

THIS MASTER EQUIPMENT LEASE AGREEMENT NO. 0135 (the "Lease") is dated as of
February 5, 1998 between PHOENIX LEASING INCORPORATED, a California corporation
("Lessor") and SEQUENOM, INC., a Delaware corporation ("Lessee").

                                   RECITALS

Lessor desires to lease to Lessee, and Lessee desires to lease from Lessor, the
equipment, machinery, fixtures, other items and intangibles including, but not
limited to laboratory and manufacturing equipment for automated process line,
high-end PC's, office equipment and furniture, as approved by Lender, and
certain custom use equipment, installation and delivery costs, purchase tax,
toolings, software, tenant improvements on off-premises equipment, equipment
located at a location other than Lesse's headquarters at 11555 Sorrento Valley
Road, San Diego, CA 92121, and items generally considered fungible or expendable
("Soft Costs") and all substitutions and replacements of and additions,
improvements, accessions and accumulations thereto, together with all rents,
issues, income, profits and proceeds therefrom (herein together called
"Equipment") which is described on the schedule attached hereto or any
subsequently-executed schedule entered into by Lessor and Lessee and which
incorporates this Lease by reference. Any such schedules shall hereinafter
individually be refined to as a "Schedule" and collectively be referred to as
the "Schedules."

NOW, THEREFORE, THE PARTIES AGREE AS FOLLOWS:

Lessor hereby leases the Equipment to Lessee upon the following terms and
conditions:

SECTION 1. TERM OF AGREEMENT. The term of this Lease begins on the date set
forth above and shall continue thereafter and be in effect so long as and at any
time any Schedule entered into pursuant to this Lease is in effect. The Base
Term and rent payable with respect to each leased item of Equipment shall be as
set forth in and as stated in the respective Schedule(s). The terms of each
Schedule hereto are subject to all conditions and provisions of this Lease as it
may at any time be amended. Each Schedule shall constitute a separate and
independent lease and contractual obligation of Lessee and shall incorporate the
terms and conditions of this Lease and any additional provisions contained in
such Schedule. In the event of a conflict between the terms and conditions of
this Lease and additional provisions of such Schedule, the additional provisions
of such Schedule shall prevail with respect to such Schedule only.

SECTION 2.  NON-CANCELLABLE LEASE.  This Lease and any Schedule cannot be
cancelled or terminated except as expressly provided herein. This Lease (which
includes any Schedule which incorporates the terms and conditions of this Lease)
constitutes a net lease and Lessee agrees that its obligations to pay all rent
and other sums payable hereunder (and under any schedule) and the rights of
Lessor and assignee in and to such rent and other sums, are absolute and
unconditional and are not subject to any abatement, reduction, setoff, defense,
counterclaim or recoupment due or alleged to be due to, or by reason or, any
past, present or future claims which Lessee may have against Lessor, any
assignee, the manufacturer or seller of the Equipment or against any person for
any reason whatsoever.
<PAGE>

SECTION 3. LESSOR COMMITMENT. Subject to the terms and conditions of this Lease
and so long as no Event of Default or event which with the giving of notice or
passage of time, or both, could become an Event of Default has occurred or is
continuing, Lessor agrees to lease to Lessee the groups of Equipment described
on each Schedule, subject to the following conditions: (a) that in no event
shall Lessor be obligated to lease Equipment to Lessee hereunder where the
aggregate purchase price of all Equipment leased to Lessee hereunder would
exceed $1,500,000 ("Commitment") of which amount Lessor may purchase Soft Costs,
for lease to Lessee having an aggregate purchase price not exceeding an amount
equal to 15% of the utilized commitment; (b) the amount of Equipment purchased
by Lessor at any one time shall be at least equal to $25,000 except for a final
advance which may, be less than $25,000; (c) Lessor shall not be obligated to
purchase Equipment hereunder after October 31, 1998; (d) all Lease documentation
required by Lessor has been executed by Lessee or provided by Lessee no later
than February 12, 1998; (e) the equipment described on the Schedule is
acceptable to Lessor; (f) with respect to each funding, Lessee has provided to
Lessor each of the closing documents and other items described in Exhibit A
hereto (which documents shall be in form and substance acceptable to Lessor) and
which list may be modified for each subsequent funding; (g) there is no material
adverse change in Lessee's condition, financial or otherwise, that would
materially impair the ability of Lessee, to meet its payment and other
obligations under this Lease, a ("Material Adverse Effect"), as reasonably
determined by Lessor, and Lessee so certifies, from (yy) the date of the most
recent financial statements delivered by Lessee to Lessor prior to execution of
this Lease to (zz) the date of the proposed lease of the Equipment; (h) at all
fundings, Lessee is performing substantially according to its business plan
referred to as "Sequenom, Inc., Financial Statement Forecast, Balance Sheet
Income Statement and Cash Flow, figures through December 31, 1998 only dated
September 24, 1997 at 7:21 AM viable through October 31, 1998", as may be
amended from time to time in form and substance reasonably acceptable to Lessor
("Business Plan"); (i) Lessor or its agent has inspected and placed
identification labels on the Equipment; (j) Lessee shall offer to Lessor, all
lease transactions for equipment contemplated by, Lessee until expiration of all
Schedules; however if Lessor declines to finance any such transaction or Lessee
and Lessor cannot agree upon terms, then Lessee shall be free to seek such
financing from any other third party; (k) Lessor has received in form and
substance reasonably acceptable to Lessor Lessee's interim financial statements
signed by a financial officer of Lessee; and (l) prior to the first funding
hereunder, Lessor has received (i) evidence satisfactory to Lessor of Lessees
receipt of Lessee's most recent equity financing in the amount of $9,350,000
deposited in United States Banks as of January 30, 1998; and (ii) evidence
satisfactory to Lessor or Lessee's $1,394,639 cash position as of September 30,
1997.

SECTION 4. NO WARRANTIES BY LESSOR. (a) Lessee has selected both (i) the
Equipment and (ii) the suppliers (herein called "Vendor") from whom Lessor is to
purchase the Equipment. LESSOR MAKES NO WARRANTY EXPRESS OR IMPLIED AS TO ANY
MATTER WHATSOEVER, INCLUDING THE CONDITION OF THE EQUIPMENT, ITS MERCHANTABILITY
OR ITS FITNESS FOR ANY PARTICULAR PURPOSE, ITS COMPLIANCE WITH ANY APPLICABLE
GOVERNMENTAL REQUIREMENTS AND ITS NON-INFRINGEMENT OF ANY PATENTS OR OTHER
RIGHTS, AND AS TO LESSOR, LESSEE LEASES THE EQUIPMENT "AS IS" AND WITH ALL
FAULTS; (b) If the

                                       2
<PAGE>

Equipment is not properly installed, does not operate as represented or
warranted by Vendor or is unsatisfactory for any reason, Lessee shall make any
claim on account thereof solely against Vendor and shall, nevertheless, pay
Lessor all rent payable under this Lease, Lessee hereby waiving any such claims
as against Lessor. Lessor hereby agrees to assign to Lessee solely for the
purpose of making and prosecuting any said claim, to the extent assignable, all
of the rights which Lessor has against Vendor for breach of warranty or other
representation respecting the Equipment. Lessor shall have no responsibility for
delay or failure to fill the order. To the extent such rights of Lessor are not
assignable, Lessor shall cooperate with Lessee in pursuing any claim against the
Vendor or manufacturer; (c) Lessee understands and agrees that neither the
Vendor nor any salesman or other agent of the Vendor is an agent of Lessor. No
salesman or agent of Vendor is authorized to waive or alter any term or
condition of this Lease, and no representations as to the Equipment or any other
matter by the Vendor shall in any way affect Lessee's duty to pay the rent and
perform its other obligations as set forth in this Lease; (d) Lessee hereby
requests Lessor to purchase Equipment from Vendor and to lease Equipment to
Lessee on the terms and conditions of the Lease set forth herein; (e) Lessee
hereby authorizes Lessor to insert in this Lease and each Schedule hereto the
serial numbers, and other identification data of the Equipment when determined
by Lessor.

SECTION 5. LESSEE'S REPRESENTATIONS AND WARRANTIES. Lessee represents and
warrants that (a) it is in good standing under the laws of the state of its
formation, and duly qualified to do business, and will remain duty qualified
during the term of this Lease, in each state where necessary to carry on its
present business and operations including the jurisdictions where the Equipment
will be located, as specified on each Schedule hereto except where failure to be
so qualified would not have a Material Adverse Effect; (b) it has full authority
to execute and deliver this Lease and perform the terms hereof, and this Lease
has been duly authorized and constitutes valid and binding obligations of Lessee
enforceable in accordance with its terms, (c) this Lease will not contravene any
law, regulation or judgment affecting Lessee or result any breach of any
material agreement or other instrument binding on Lessee; (d) no consent of
Lessee's shareholders, members or managers or partners, as applicable, or holder
of any indebtedness, or filing with, or approval of, any governmental agency or
commission, is a condition to the performance of the terms hereof; (e) there is
no action or proceeding pending or threatened against Lessee before any court or
administrative agency which might result in a Material Adverse Effect on the
business, financial condition or operations of Lessee; (f) no deed of trust,
mortgage or third party interest arising through Lessee will attach to the
Equipment or the Lease; (g) the Equipment will remain at all times under
applicable law, removable personal property, free and clear of any lien or
encumbrance in favor of Lessee or any other person, notwithstanding the manner
in which the Equipment may be attached to any real property; (h) all credit
financial and any other information submitted to Lessor herewith or any other
time is true and correct; and (i) Lessee has provided or will provide if
requested, Lessee's tax identification number.

SECTION 6. EQUIPMENT ORDERING. Lessee shall be responsible for all packing,
rigging, transportation and installation charges for the Equipment and Lessor
may separately invoice Lessee for such charges. Lessee has selected the
Equipment itself and shall arrange for delivery of Equipment so that it can be
accepted in accordance with Section 7 hereof. Lessee

                                       3
<PAGE>

hereby agrees to indemnify and hold Lessor harmless from any claims,
liabilities, costs and expenses, including reasonable attorneys' fees, incurred
by Lessor arising out of any purchase orders or assignments executed by Lessor
with respect to any Equipment or services relating thereto.

SECTION 7. LESSEE ACCEPTANCE. Lessee shall return to Lessor the signed and dated
Acceptance Notice attached to each Schedule hereto (a) acknowledging the
Equipment has been received, installed and is ready for use and (b) accepting it
as satisfactory in all respects for the purposes of this Lease. Lessor is
authorized to fill In the Rent Start Date on each Schedule in accordance with
the foregoing.

SECTION 8. LOCATION; INSPECTION; LABELS. The Equipment shall be delivered to and
shall not be removed from the Equipment "Location" shown on each Schedule
without Lessor's prior written consent, which Location shall in all events be
within the United States. Lessor shall have the night to inspect the Equipment
including records relating thereto, and Lessee's books and records at any time
(upon reasonable notification) during regular business hours, such books and
records to be maintained in accordance with generally accepted accounting
principles. Lessee shall be responsible for all labor, material and freight
charges incurred in connection with any removal or relocation of such Equipment
which is requested by the Lessee and consented to by Lessor, as well as for any
charges due to the installation or moving of the Equipment. The rental payments
shall continue during any period shall continue during any period in which the
Equipment is in transit during a relocation. Lessor or its agent shall mark and
label the Equipment, which labels (to be provided by Lessor) shall state the
Equipment is owned by Lessor, and Lessee shall keep such labels on the Equipment
as labeled by Lessor or its agents provided that such labels will not interfere
with use of the Equipment for the purpose for which it is intended.

SECTION 9.  EQUIPMENT MAINTENANCE.  (a) General.  Lessee will locate or base
                                        -------
each item of Equipment where designated in the Acceptance Notice and will
reasonably permit Lessor to inspect, at reasonable times and frequency, such
item of Equipment and its maintenance records.  Lessee will at its sole expense
comply with all applicable laws, rules, regulations, requirements and orders
with respect to the use, maintenance, repair, condition, storage and operation
of each item of Equipment.  Except as required herein, Lessee will not make any
addition or improvement to any item of Equipment that is not readily removable
without causing material damage to any item or impairing its original value or
utility.  Any addition or improvement that is so required or cannot be so
removed will immediately become the property of Lessor; (b) Service and Repair.
                                                            ------------------
Lessee will, at its sole expense, maintain and service, and repair any damage
to, each item of Equipment in a manner consistent with prudent industry practice
and Lessee's own practice so that such item of Equipment is at all times (i) in
the same condition as when delivered to Lessee, except for ordinary wear and
tear, (ii) in good operating order for the function intended by its
manufacturer's warranties and recommendations.

SECTION 10. LOSS OR DAMAGE. Lessee assumes the entire risk of loss to the
Equipment through use, operation or otherwise. Lessee hereby indemnifies and
holds harmless Lessor from and against all claims, loss of rental payments,
costs, damages, and expenses

                                       4
<PAGE>

relating to or resulting from any loss, damage or destruction of the Equipment,
any such occurrence being hereinafter called a "Casualty Occurrence." No
Casualty Occurrence shall relieve Lessee from the obligation to pay rent or from
any other obligation under the Lease. No later than the first rental payment
date following such Casualty Occurrence, or, if there is no such rental payment
date, no later than thirty (30) days after such Casualty Occurrence, Lessee
shall either (a) repair the Equipment, returning it to good operating condition,
(b) replace the Equipment with identical equipment in good condition and repair,
the title to which shall vest in Lessor and which thereafter shall be subject to
the terms of this Lease; or (c) on the first rental payment date following the
Casualty Occurrence, pay to Lessor (i) any unpaid accrued amounts relating to
such Equipment due Lessor under this Lease up to the date of the Casualty
Occurrence, and (ii) a sum equal to the Casualty Value as set forth in the
Casualty Value table attached to each Schedule hereto for such Equipment. Upon
the making of such payment, the term of this Lease as to each unit of Equipment
with respect to which the Casualty Value was paid shall terminate.

SECTION 11. GENERAL INDEMNITY. Lessee will protect, indemnify and save harmless
Lessor and any assignees on an after-tax basis from and against all liabilities,
obligations, claims, damages, penalties, causes of action, costs and expenses
(including reasonable attorneys' fees and expenses), imposed upon or incurred by
or asserted against Lessor or any assignee of Lessor by Lessee or any third
party by reason of the occurrence or existence (or alleged occurrence or
existence) of any act or event relating to or caused by the Equipment or its
purchase, acceptance, possession, use, maintenance or transportation, including
but not limited to, consequential or special damages of any kind, or any failure
on the part of Lessee to perform or comply with any of the terms of this Lease,
claims for latent or other defects, claims for patent, trademark or copyright
infringement and claims for personal injury, death or property damage, including
those based on Lessor's negligence or strict liability in tort and excluding
only that based on Lessor's gross negligence or willful misconduct only if such
claims relate to the Equipment. In the event that any action, suit or proceeding
is brought against Lessor by reason of any such occurrence, Lessee, upon request
of Lessor, will at Lessee's expense resist and defend such action, suit or
proceeding or cause the same to be resisted and defended by counsel designated
and approved by Lessor. Lessee's obligations under Section 11 shall survive the
expiration of this Lease with respect to acts or events occurring or alleged to
have occurred prior to the return of the Equipment to Lessor at the end of the
Lease term.

SECTION 12. INSURANCE. Lessee at its expense shall keep the Equipment insured
for the entire term and any extensions of this Lease against all risks of
physical loss for at least the replacement value of such Equipment and in no
event for less than the amount payable following a Casualty Occurrence (as
provided in Section 10) and shall provide for a loss payable endorsement to
Lessor and/or any assignee of Lessor. Lessee shall maintain commercial general
liability insurance with respect to loss or damage for personal injury, death or
property damage in an amount not less than S2,000,000 in the aggregate, naming
Lessor and/or Lessor's assignee as additional insured. Such insurance shall
contain insurer's agreement to give thirty (30) days' advance written notice to
Lessor before cancellation or material change of any policy of insurance. Lessee
will provide Lessor and any assignee of Lessor with a certificate of insurance
from the insurer evidencing Lessor's or such assignees interest in the policy of
insurance. Such

                                       5
<PAGE>

insurance shall cover any Casualty Occurrence to any unit of Equipment.
Notwithstanding anything in Section 10 or this Section 12 to the contrary, this
Lease and Lessee's obligations hereunder and under each Schedule shall remain in
full force and effect with respect to any unit of Equipment which is not subject
to a Casualty Occurrence. If Lessee fails to provide or maintain insurance as
required herein, Lessor shall have the right, but shall not be obligated to
obtain such insurance. In that event, Lessee shall pay to Lessor the cost
thereof.

SECTION 13 TAXES. Lessee agrees to report the Equipment as equipment leased from
Lessor and not as equipment owned by Lessee on Lessee's personal property tax
return. Promptly upon receipt of an invoice from Lessor, Lessee agree to
reimburse Lessor for (or pay directly if instructed by Lessor), and agrees to
indemnify and hold Lessor harmless from, all fees (including, but not limited
to, license, documentation, recording and registration fees), and all sales,
use, gross receipts, personal property, occupational, value added or other
taxes, levies, imposts, duties, assessments, charges, or withholdings of any
nature whatsoever, together with any penalties, fines, additions to tax, or
interest thereon (all of the foregoing being hereafter referred to as
"Impositions") except same as way be attributable to Lessor's income, arising at
any time prior to or during the term of this Lease, or upon termination or early
termination of this Lease and levied or imposed upon Lessor directly or
otherwise by any Federal, state or local government in the United States or by
any foreign country or foreign or international taxing authority upon or with
respect to (a) the Equipment, (b) the exportation, importation, registration,
purchase, ownership, delivery, leasing, possession, use, operation, storage,
maintenance, repair, return, sale, transfer of title, or other disposition
thereof, (c) the rentals, receipts, or earnings arising from the Equipment, or
any disposition of the rights to such rentals, receipts, or earnings, (d) any
payment pursuant to this Lease, and (e) this Lease or the transaction or any
part thereof. Lessee's obligations under this Section 13 shall survive the
expiration of this Lease with respect to acts or events occurring or alleged to
have occurred prior to the return of the Equipment to Lessor at the end of the
Lease term.

SECTION 14. METHOD AND PLACEMENT OF PAYMENT. Lessee shall pay to Lessor, at its
office at the address specified in the Schedules, or such other address as
Lessor specifies in writing, all amounts payable to it in respect of the
Schedules.

SECTION 15. SURRENDER OF EQUIPMENT. If required by the terms of this Lease or
any Schedule, Lessee will forthwith surrender the Equipment to Lessor delivered
in as good order and condition as originally delivered, reasonable wear and tear
excepted. Lessor may, at its sole option, arrange for removal and transportation
of the Equipment provided that Lessee's obligations under Sections 10, 11 and 12
shall not be released. Lessee shall bear all expenses of delivering (which
include, but are not limited to, the de-installation, insurance, packaging and
transportation of) the Equipment to Lessor's location or other location within
the United States as Lessor may request. Notwithstanding Lessee's surrender
under this Lease, including rental payments, shall remain in full force and
effect until Lessee delivers the Equipment to Lessor.

SECTION 16. MISCELLANEOUS AFFIRMATIVE COVENANTS. So long as any payment required
of Lessee hereunder is unpaid and as long as any obligations of Lessee under
this Lease remain outstanding, Lessee will: (a) duly pay all governmental taxes
and assessments

                                       6
<PAGE>

at the time they become due and payable; (b) comply with all applicable
governmental laws, rules and regulations relating to the business and the
Equipment; (c) maintain Lessor's ownership interest in the Equipment; (d)
furnish Lessor with its annual audited financial statements within ninety (90)
days following the end of Lessee's fiscal year, unaudited quarterly financial
statements within thirty (30) days after the end of each fiscal quarter, and
within fifteen (15) days of the end of each month a financial statement for that
month prepared by Lessee, including all financial information given to Lessee's
Board of Directors, and including an income statement and balance sheet, all of
which shall be certified by an officer of Lessee as true and correct and shall
be prepared in accordance with generally accepted accounting principles
consistently applied, and such other information as Lessor may reasonably
request; (e) promptly (but in no event more than five (5) days after the
occurrence of such event) notify Lessor of any Material Adverse Effect regarding
Lessee's condition during the commitment period and of the occurrence of any
Event of Default; and (f) take all steps deemed by Lessor reasonable or
advisable to validate Lessor's ownership of the Equipment.

SECTION 17. ASSIGNMENT. WITHOUT LESSOR'S PRIOR WRITTEN CONSENT, WHICH CONSENT
WILL NOT BE UNREASONABLY WITHHELD OR DELAYED, LESSEE SHALL NOT (a) ASSIGN,
TRANSFER, PLEDGE, HYPOTHECATE OR OTHERWISE DISPOSE OF THIS LEASE, ANY SCHEDULES,
THE EQUIPMENT, OR ANY INTEREST THEREIN, OR (b) SUBLET OR LEND EQUIPMENT OR
PERMIT IT TO BE USED BY ANYONE OTHER THAN LESSEE OR LESSEE'S EMPLOYEES, OR (c)
MERGE INTO, CONSOLIDATE WITH OR CONVEY OR TRANSFER ITS PROPERTIES SUBSTANTIALLY
AS AN ENTIRETY TO ANY OTHER PERSON OR ENTITY EXCEPT TO A SUCCESSOR IN INTEREST
TO ALL OR SUBSTANTIALLY ALL OF THE BUSINESS OF LESSEE; PROVIDED, HOWEVER, THAT,
THE FINANCIAL CONDITION OF SUCH SUCCESSOR IS GREATER THAN OR EQUAL TO THAT OF
LESSEE, AS DETERMINED IN GOOD FAITH BY LESSOR, AND THE SUCCESSOR'S BUSINESS AND
ITS MAJOR INVESTORS ARE REASONABLY ACCEPTABLE TO LESSOR. LESSOR MAY ASSIGN THIS
LEASE AND ANY SCHEDULES OR GRANT A SECURITY INTEREST IN ANY OR ALL EQUIPMENT, OR
BOTH, IN WHOLE OR IN PART TO ONE OR MORE ASSIGNEES OR SECURED PARTIES WITHOUT
NOTICE TO LESSEE. If Lessee is given notice of such assignment it agrees to
acknowledge receipt thereof in writing and Lessee shall execute such additional
documentation as Lessor's assignee and/or secured party shall reasonably
require. Each such assignee and/or secured party shall have all of the rights,
but (except as provided in this Section 17) none of the obligations, of Lessor
under this Lease, unless such assignee or secured party expressly agrees to
assume such obligations in writing. Lessee shall not assert against any assignee
and/or secured party any defense, counterclaim or offset that Lessee may have
against Lessor. Notwithstanding any such assignment, and providing no Event of
Default has occurred and is continuing, Lessor, or its assignees, secured
parties, or their agents or assigns, shall not interfere with Lessee's right to
quietly enjoy use of Equipment subject to the terms and conditions of this
Lease. Subject to the foregoing, this Lease inures to the benefit of and is
binding upon the successors and assignees of the parties hereto. Lessee
acknowledges that any such assignment by Lessor will not materially change
Lessee's duties or obligations under the Lease or increase any burden of risk on
Lessee.

                                       7
<PAGE>

SECTION 18.  DEFAULT.  (a) Events of Default.  Any of the following events or
                           -----------------
conditions shall constitute an "Event of Default" hereunder: (i) Lessee's
failure to pay any monies due to Lessor hereunder or under any Schedule beyond
the tenth (10th) day after the same is due; (ii) Lessee's failure to comply with
its obligations under Section 12 or Section 17; (iii) Any representation or
warranty of Lessee made in this Lease or the Schedules or in any other
agreements, statement or certificate furnished to Lessor in connection with this
Lease or the Schedules shall prove to have been incorrect in any material
respect when made or given; (iv) Lessee's failure to comply with or perform any
term, covenant, condition, warranty or representation of this Lease or any
Schedule hereto or under any other agreement between Lessee and Lessor or under
any lease or mortgage of real property covering the location of Equipment if
such failure to comply or perform is not cured by Lessee within thirty (30) days
after Lessee knows of the non-compliance or nonperformance or notice from
Lessor; (v) seizure of the Equipment under legal process; (vi) the filing by or
against Lessee or any guarantor under any guaranty executed in connection with
this Lease ("Guarantor") of a petition for reorganization or liquidation under
the Bankruptcy Code or any amendment thereto or under any other insolvency law
providing for the relief of debtors; (vii) the voluntary or involuntary making
of an assignment of a substantial portion of its assets by Lessee, or by any
Guarantor, for the benefit of its creditors, the appointment of a receiver or
trustee for Lessee or any Guarantor for any of Lessee's or Guarantor's assets,
the institution by or against Lessee or any Guarantor of any formal or informal
proceeding for dissolution, liquidation, settlement of claims against or winding
up of the affairs of Lessee or any Guarantor, provided that in the case of all
                                              ---------
such involuntary proceedings, same are not dismissed within sixty (60) days
after commencement; or (viii) the making by Lessee or any Guarantor of a
transfer of all or a material portion of Lessee's or Guarantor's assets or
inventory not in the ordinary course of business; or (ix) any default or breach
by any Guarantor of any of the terms of its guaranty to Lessor in connection
with this Lease.

     (b) Remedies.  If any Event of Default has occurred, Lessor may in its sole
         --------
discretion exercise one or more of the following remedies with respect to any or
all of the Equipment (i) Lessor may proceed by appropriate court action or
actions either at law or in equity to enforce performance by Lessee, of the
applicable covenants of this Lease, or to recover damages therefor, (ii) Lessee
will, without demand, on the next rent payment date following the Event of
Default, pay to Lessor as liquidated damages which the parties agree are fair
and reasonable under the circumstances existing at the time this Lease is
entered into, and not as a penalty, an amount equal to the Casualty Value of the
Equipment set forth in the Casualty Value Table attached to such Equipment's
Schedule together with any rent or other amounts past due and owing by Lessee
hereunder; (iii) Lessor may, without notice to or demand upon Lessee; (A) Take
possession of the Equipment and lease or sell the same or any portion thereof,
for such period, amount, and to such entity as Lessor shall elect.  The proceeds
of such lease or sale will be applied by Lessor (1) first, to pay all costs and
expenses, including reasonable legal fees and disbursements, incurred by Lessor
as a result of the default and the exercise of its remedies with respect
thereto, (2) second, to pay Lessor an amount equal to any unpaid rent or other
amounts past due and payable plus the Casualty Value, to the extent not
previously paid by Lessee, and (3) third, to reimburse Lessee for the Casualty
Value to the extent previously paid.  Any surplus

                                       8
<PAGE>

remaining thereafter will be retained by Lessor, (B) Take possession of the
Equipment and hold and keep idle the same or any portion thereof.

Lessee agrees to pay all reasonable out-of-pocket costs of Lessor incurred in
enforcement of this Lease, the Schedules or any instrument or agreement required
under this Lease, including but not limited to reasonable outside counsel legal
fees and litigation expenses and fees of collection agencies ("Remedy
Expenses"). At Lessor's request, Lessee shall assemble the Equipment and make it
available to Lessor at such location as Lessor relay reasonably designate.
Lessee waives any right it may have to redeem the Equipment.

No delay or omission of Lessor, in exercising any right or power arising from
any Event of Default shall prevent Lessor from exercising that right or power if
the Event of Default continues. No waiver of an Event of Default, whether full
or partial, by Lessor or such holder shall be taken to extend to any subsequent
Event of Default or to impair the rights of Lessor in respect of any damages
suffered as a result of the Event of Default. The giving, taking or enforcement
of any other or additional security, Equipment at or guaranty for the payment or
discharge of the lease obligations and performance of the obligations shall in
no way operate to prejudice, waive or affect Lessor's ownership interest created
under this Lease or any rights, powers or remedies exercised hereunder or
thereunder. Lessor shall not be required first to repossess the Equipment prior
to bringing an action against Lessee for sums owed to Lessor under this Lease or
under any Schedule.

SECTION 19. LATE PAYMENTS. Lessee shall pay to Lessor an amount equal to the
lesser of 8% of any payment owed Lender by Borrower which is not paid when due
(taking into account applicable grace periods),of every month such payment to
not paid when due, but in no event an amount greater than the highest rate
permitted by applicable law. If such amounts have not been received by Lessor at
Lessor's place of business or by Lessor's designated agent by the date such
amounts due under this Lease, Lessor shall bill Lessee for such charges. Lessee
acknowledges that invoices for rentals due hereunder or under the Schedules are
sent by Lessor for Lessee's convenience only. Lessee's non-receipt of an invoice
will not relieve Lessee of its obligation to make rent payments hereunder or
under the Schedules.

SECTION 20. LESSOR'S EXPENSE. Lessee shall pay Lessor all reasonable costs and
expenses including reasonable attorney's fees and the fees of collection
agencies, incurred by Lessor (a) in enforcing any of the terms, conditions or
provisions hereof any related to the exercise of its remedies, and (b) in
connection with any bankruptcy or post-judgment proceeding, whether or not suit
is filed and, in each and every action, suit or proceeding, including any and
all appeals and petitions therefrom.

SECTION 21. PAYMENTS BY LESSOR. If Lessee shall fail to make any payment or
perform any act required hereunder (including, but not limited to, maintenance
of any insurance required by Section 12), then Lessor may but shall not be
required to, after such notice to Lessee as is reasonable under the
circumstances, make such payment or perform such act with the same effect as if
made or performed by Lessee. Lessee will upon demand reimburse Lender for all

                                       9
<PAGE>

sums paid and all costs and expenses incurred in connection with the performance
of any such act.

SECTION 22. OWNERSHIP; PERSONAL PROPERTY. The Equipment shall be and remain
personal property of Lessor, and Lessee shall have no right, title or interest
therein or thereto except as expressly set forth in this Lease, notwithstanding
the manner in which it may be attached or affixed to real property, and upon
termination or expiration of the Lease term, Lessee shall have the duty and
Lessor shall have the right to remove the Equipment from the premises where the
same be located whether or not affixed or attached to the real property or any
building, at the cost and expense of Lessee.

SECTION 23. ALTERATIONS; ATTACHMENT. No alterations or attachments shall be made
to the Equipment without Lessor's prior written consent, which shall not be
given for changes that will affect the reliability and utility of the Equipment
or which cannot be removed without damage to the Equipment, or which in any way
affect the value of the Equipment for purposes of resale or re-lease. All
attachments and improvements to the Equipment shall be deemed to be "Equipment"
for purposes of the Lease, and all right, title and interest therein shall
immediately vest in Lessor.

SECTION 24. FINANCING STATEMENT. Lessee will execute all financing statements
pursuant to the Uniform Commercial Code and all such other documents reasonably
requested by Lessor to protect Lessor's interest hereunder. Lessee authorizes
Lessor to file financing statements signed only by Lessor (where such
authorization is permitted by law) at all places where Lessor deems necessary.

SECTION 25. MISCELLANEOUS. (a) Lessee shall provide Lessor with such corporate
resolutions, financial statements and other documents as Lessor shall reasonably
request from time to time; (b) Lessee represents that the Equipment is being
leased hereunder for business purposes; (c) Time is of the essence with respect
to this Lease; (d) Lessee shall keep its books and records in accordance with
generally accepted accounting principles and practices consistently applied and
shall deliver to Lessor its annual audited financial statements, unaudited
monthly financial statements to include any financial information given to
Lessee's Board of Directors, and signed by an officer of Lessee and such other
unaudited financial statements as may be reasonably requested by Lessor; (e) Any
action by Lessee against Lessor for any default by Lessor under this Lease,
including breach of warranty or indemnity, shall be commenced within one (1)
year after any such cause of action accrues; (f) Lessee will notify Lessor at
least 30 days prior to changing its name, principal place of business or chief
executive office; (g) The obligations of Lessee hereunder shall survive the
expiration or earlier termination of this Lease and the Schedules until all such
obligations of Lessee to Lessor have been met and all liabilities of Lessee to
Lessor or any assignee have been paid in full; (h) Lessee hereby appoints Lessor
(and each of Lessor's officers, employees or agents designated by Lessor) with
full power of substitution by Lessor, as Lessee's attorney, with power to
execute and deliver on Lessee's behalf, financing statements and other documents
necessary to perfect and/or give notice of Lessor's ownership of any of the
Equipment.

                                       10
<PAGE>

SECTION 26.  NOTICES. All notices hereunder shall be in writing, by registered
mail, or reliable messenger or delivery service and shall be directed, as the
case may be, to Lessor at 2401 Kerner Boulevard, San Rafael, California 94901,
Attention: Asset Management and to Lessee at 11555 Sorrento Valley Road, San
Diego, CA 92121, County of San Diego, Attention: Mr. Steve Zaniboni, Vice
President, Finance and Administration.

SECTION 27.  ENTIRE AGREEMENT. Lessee acknowledges that Lessee has read this
Lease, understands it and agrees to be bound by its terms, and further agrees
that the Lease and each Schedule constitute the entire agreement between Lessor
and Lessee with respect to the subject matter hereof and supersedes all previous
agreements, promises, or representations. The terms and conditions hereof shall
prevail notwithstanding any variance with the terms of any purchase order
submitted by the Lessee with respect to any Equipment covered hereby.

SECTION 28.  AMENDMENT. This Lease may not be changed, altered or modified
except by an instrument in writing signed by an officer of the Lessor and the
Lessee.

SECTION 29.  WAIVER. Any failure of Lessor to require strict performance by
Lessee or any waiver by Lessor of any provision herein shall not be construed as
a consent or waiver of any other breach of the same or any other provision.

SECTION 30.  SEVERABILITY. If any provision of this Lease or a Schedule is held
invalid, such invalidity shall not affect any other provisions hereof or
thereof.

SECTION 31.  JURISDICTION AND WAIVER OF JURY TRIAL. This Lease shall be deemed
to have been negotiated, entered into and performed in the State of California
and it is understood and agreed that the validity of this Lease and of any of
its terms and provisions, as well as the rights and duties of the parties to
this Lease, shall be construed pursuant to and in accordance with the laws of
the State of California, without giving effect to conflicts of law principles.
It is agreed that exclusive jurisdiction and venue for any legal action between
the parties arising out of this Lease shall be in the Superior Court for Marin
County, California, or, in cases where Federal diversity jurisdiction is
available, in the United States District Court for the Northern District of
California situated in San Francisco. LESSEE, TO THE EXTENT IT MAY LAWFULLY DO
SO, HEREBY WAIVES ITS RIGHT TO TRIAL BY JURY IN ANY ACTION BROUGHT ON OR WITH
RESPECT TO THIS LEASE, ANY SCHEDULE, OR ANY AGREEMENT EXECUTED IN CONNECTION
HEREWITH.

SECTION 32.  NATURE OF TRANSACTION. Lessor makes no representation whatsoever,
express or implied, concerning the legal character of the transaction evidenced
hereby, for tax or any other purpose.

SECTION 33.  SECURITY INTEREST. (a) One executed copy of the Lease will be
marked "Original" and all other counterparts will be duplicates. To the extent,
if any, that this Lease constitutes chattel paper (as such term is defined in
the Uniform Commercial Code as in effect in any applicable jurisdiction) no
security interest in the Lease may be created in any documents other than the
"Original." (b) There shall be only one original of each Schedule and

                                       11
<PAGE>

it shall be marked "Original," and all other counterparts will be duplicates. To
the extent, if any, that any Schedule(s) to this Lease constitutes chattel paper
(or as such term is defined in the Uniform Commercial Code as in effect in any
applicable jurisdiction) no security interest in any Schedule(s) may be created
in any documents other than the "Original."

SECTION 34.  SOFTWARE. For the term of this Lease, and so long as no Event of
Default has occurred and is continuing, Lessor hereby assigns to Lessee all of
Lessor's rights under any License Agreement executed by Lessor in connection
with the Equipment (except for any right of Lessor to be reimbursed for the
License Fee). Lessee agrees to be bound by the provisions of any such License
Agreement and to perform all obligations of Lessor (except Lessor's payment
obligations) thereunder. Lessee acknowledges that all of Lessee's obligations
under the Lease with respect to the Equipment will apply equally to the
software, including but not limited to Lessee's obligation to pay rent to
Lessor.

SECTION 35.  COMMITMENT FEE. Lessee has paid to Lessor a commitment fee ("Fee")
of $15,000. The Fee shall be applied by Lessor first to reimburse Lessor for all
out-of-pocket UCC and other search costs, inspections and appraisal fees
incurred by Lessor, and then proportionally to the first month's rent for each
Schedule hereunder in the proportion that the purchase price of the Equipment
leased pursuant to the Schedule bears to Lessor's entire commitment. However,
the portion of the Fee which is not applied to rental shall be non-refundable
except if Lessor defaults in its obligations pursuant to Section 3.

SECTION 36.  FINANCE LEASE. The parties agree that this lease is a "Finance
Lease" as defined by section 10-103(a)(7) of the California Commercial Code
(Cal.Com.C.). Lessee acknowledges either (a) that Lessee has reviewed and
approved any written Supply Contract (as defined by Cal.Com.C. Section 10-
103(a)(25)) covering Equipment purchased from the "Supplier" (as defined by
Cal.Com.C. Section 10-103(a)(24)) thereof for lease to Lessee or (b) that Lessor
has informed or advised Lessee, in writing, either previously or by this Lease
of the following: (i) the identity of the Supplier; (ii) that the Lessee may
have rights under the Supply Contract; and (iii) that the Lessee may contact the
Supplier for a description of any such rights Lessee may have under the Supply
Contract. Lessee hereby waives any rights and remedies Lessee may have under
Cal.Com.C. Sections 10-508 through 522.

SECTION 37.  END OF LEASE POSITION. (a) General.  Lessee shall be required to
                                        -------
choose a final purchase or extension requirement ("End of lease Position") at
the expiration of the Base Term (as defined in the Schedule) of the first
Schedule to the Lease. That choice shall be an election of Lessee's End of Lease
Position for all, but not less than all, of the Equipment under all Schedules to
the Lease. Lessee shall provide written notice of its election to Lessor at
least 90 days prior to the end of the Base Term of the first Schedule.

Any Equipment purchase election shall be a purchase of the Equipment, AS-IS,
WHERE-IS, Upon Lessor's receipt of the purchase price, Lessor shall issue to
Lessee an equipment bill of sale, transferring title to the Equipment to the
Lessee without any representation or warranty whatsoever. Lessee shall be
responsible for all applicable taxes in connection with any Equipment purchase.

                                       12
<PAGE>

In the event Lessee does not provide at least 90 days' prior written notice of
its election, Lessee shall be deemed to have elected Election No. 2.

At the expiration of the Base Term of the first Schedule Lessee shall be
required to elect to either:

Election No. 1:  Purchase the Equipment for 25% of the Equipment's original
- --------------
purchase price; or

Election No. 2:  Extend the Schedule's Base Term for an additional 12 months
- --------------
("Extended Term") for a monthly rate of 2.50% of the Equipment's original
purchase price.

At the expiration of the Extended Term, Lessee shall purchase the Equipment for
$1.00.

SECTION 38.  ADJUST-A-LEASE OPTION.

(a) General:  Subject to credit and equipment review and approval, Lessee shall
have the option to remove such Schedule's Equipment ("Removed Equipment") and
finance new Equipment ("New Equipment") under a new Schedule ("New Schedule").

(b)  New Schedule Amount:  The amount of the New Schedule shall be an amount
equal to the purchase price for the New Equipment plus a prepayment figure for
the Removed Equipment. The prepayment figure shall be the amount of the original
Schedule ("Old Schedule") less: (i) any trade-in or resale value for the Removed
Equipment and (ii) a credit for Schedule payments already made (the total Old
Schedule payments attributable to the removed Equipment multiplied by the
"Allowance Factor" indicated in the table below). In no event shall the amount
of the New Schedule be less than the amount of the Old Schedule.

<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------
Removal Date                                           Allowance Factor

- -----------------------------------------------------------------------------------------------
<S>                                                    <C>
After 12 Months of Old Schedule                        55%

- -----------------------------------------------------------------------------------------------
After 24 Months of Old Schedule                        60%

- -----------------------------------------------------------------------------------------------
After 36 Months of Old Schedule                        65%

- -----------------------------------------------------------------------------------------------
</TABLE>

(c.) Old Schedule:  If any Equipment remains on the Old Schedule, the monthly
payment amount for the Old Schedule will be reduced in proportion to the
Removed Schedule's value.

(d)  Option Preconditions:  Borrower's right to exercise this Adjust-A-Lease
Option ("Option") is conditioned upon the following: (i) no Event of Default
under the Lease has theretofore occurred or is continuing; (ii) the New
Equipment and prepayment of the Removed Equipment are financed by Lessor under a
New Schedule, subject to Lessor's current lease rates and documentation
acceptable to Lessor, (iii) Lessor is satisfied with Lessee's creditworthiness;

                                       13
<PAGE>

(iv) the New Equipment is acceptable to Lessor; and (v) Lessee has given Lessor
at least 90 days' prior written notice of its desire to exercise the Option.

SECTION 39.  FURTHER ASSURANCES. Lessee shall at its expense take such action
and execute and deliver all acts and instruments and other documents as Lessor
may at any time request to protect, assure or enforce its interests and rights
hereunder.

SECTION 40.  POWER OF ATTORNEY. Lessee hereby irrevocably appoints Lessor as
Lessee's attorney-in-fact, with full authority in the place and stead of Lessee
and in the name of Lessee, from time to time in Lessor's discretion, to take any
action and to execute any instrument which Lessor may deem necessary or
advisable to accomplish the purposes of the Lease and any documents and
instruments contained therein or thereby to the extent permitted by law.

IN WITNESS WHEREOF, the parties hereto have executed this Lease.

<TABLE>
<CAPTION>
- -------------------------------------------------------------------------------------------------------
PHOENIX LEASING INCORPORATED                           SEQUENOM, INC.
<S>                                                    <C>
By:     /s/  Ellen Gillen                              By:       /s/  Stephen Zanziboni
   ---------------------------------------                --------------------------------------------

Name:     Ellen Gillen                                 Name (Print):     Stephen Zanziboni
     -------------------------------------                           ---------------------------------

Title:     AVP Credit Manager                          Title:       VP Finance
      ------------------------------------                   -----------------------------------------

                                                       HEADQUARTERS LOCATION:
                                                       ----------------------
                                                       11555 Sorrento Valley Road
                                                       San Diego, CA  92121
                                                       County of San Diego

                                                       EXHIBITS AND SCHEDULES:
                                                       ----------------------
                                                       Exhibit A--Closing Memorandum

- ------------------------------------------------------------------------------------------------------
</TABLE>

                                       14
<PAGE>

                                                                    EXHIBIT A TO
                                       MASTER EQUIPMENT LEASE AGREEMENT NO. 0135
                                                          DATED FEBRUARY 5, 1998


                               CLOSING MEMORANDUM
                               ------------------

1.*  Duly executed Master Equipment Lease marked "Original."
2.   Duly executed Schedule marked "Original."
3.   Duly executed Certificate of Acceptance. [EXECUTE UPON ACCEPTANCE OF
     EQUIPMENT]
4.   Insurance Certificates.
5.*  Resolutions of Lessee's Board of Directors, including an incumbency
     certificate.
6.*  Copy of Lessee's articles of incorporation including all amendments,
     certified by the Secretary of Lessee as being true and complete and in full
     force and effect.
7.*  Certificate from the Secretary of State of Lessee's state of incorporation,
     from the state in which Lessee's chief executive office is located, if
     different, and from each state where Lessee is qualified to do business,
     stating Lessee is in good standing or is authorized to transact business,
     as the case may be, dated not more than thirty days prior to the first
     purchase of Equipment.
8.   Real Property Waiver.**
9.   UCC Financing Statements.
10.  Bill of Sale (for Sale-Leaseback Equipment).
11.. UCC search.
12.  Equipment List, in form and substance satisfactory to Lessor.
13.  Lessee's most recent financial statements.
14.  Certificate of Chief Financial Officer stating that no event of default has
     occurred, there is no adverse change in the financial condition of Lessee
     and that the Equipment is free of any encumbrances.
15.  See Section 3 of Master Equipment Lease for additional preconditions to
     closing.
20.  Intercreditor Agreement, if applicable.


*First Schedule Only.

**Required if any Equipment is a fixture, i.e., attached to real property, or
located in certain states.

                                       15
<PAGE>

                         CORPORATE RESOLUTION TO LEASE

RESOLVED:  That this corporation, SEQUENOM, INC., lease from PHOENIX LEASING
INCORPORATED, a California corporation, hereinafter referred to as Lessor, such
items of personal property, and upon such terms and conditions, as the officer
or officers hereinafter authorized, in their discretion, may deem necessary or
advisable; provided, however, that the original actual cost of such items of
personal property under the lease shall not exceed the sum of $1,500,000.

RESOLVED FURTHER: That:

      Stephen Zaniboni              VP Finance           /s/  Stephen Zaniboni
- -------------------------  ----------------------------  ----------------------
(Print or type name)       (Title of Corporate Officer)   (Specimen Signature)

or

- -------------------------  ----------------------------  ---------------------
(Print or type name)       (Title of Corporate Officer)  (Specimen Signature)


of this corporation (this officer or officers authorized to act pursuant hereto
being hereinafter designated as "authorized officers"), be, and they hereby are,
individually authorized, directed and empowered, in the name of this
corporation, to execute and deliver to Lessor, and Lessor is requested to
accept, any lease that may be required by Lessor in connection with such leasing
of personal property.

RESOLVED FURTHER: That the authorized officers be, and they hereby are,
individually authorized, directed and empowered, in the name of this
corporation, to do or cause to be done all such further acts and things as they
shall deem necessary, advisable, convenient, or proper in connection with the
execution and delivery of any such lease and in connection with or incidental to
the carrying of the same into effect, including, without limitation the
execution, acknowledgment, and delivery of any and all instruments and documents
which may reasonably be required by Lessor under or in connection with any such
lease.

RESOLVED FURTHER: That Lessor is authorized to act upon this resolution until
written notice of its revocation is delivered to Lessor, and that the authority
hereby granted shall apply with equal force and effect to the successors in
office of the officers herein named.

I, Hubert Koster, Officer of SEQUENOM, INC., a corporation incorporated under
   -------------
the laws of the State of Delaware, do hereby certify that the foregoing is a
full, true and correct copy of resolutions of the Board of Directors of the said
corporation, duly and regularly passed or adopted by the Board of Directors of
said corporation, duly and regularly passed or adopted by the Board of Directors
of said corporation as required by law and by the by-laws of the said
corporation on the 25 day of February, 1998.
                   --        --------    --

                                       16
<PAGE>

I further certify that said resolutions are still in full force and effect and
have not been amended or revoked and that the specimen signatures appearing
above are the signatures of the officers authorized to sign for this corporation
by virtue of the said resolutions.

IN WITNESS WHEREOF, I have hereunto set my hand as such Officer, and affixed the
corporate seal of the said corporation, this 25 day of February, 1998.
                                                                   --

                                       AFFIX CORPORATE
                                    SEAL HERE


                                                    /s/ illegible
                                            ----------------------------
                                                  OFFICER OF SEQUENOM, INC.
                                                   President & CEO

                                       17
<PAGE>

          AMENDMENT NO. 1 TO MASTER EQUIPMENT LEASE AGREEMENT NO. 0135

THIS AMENDMENT NO. 1 TO MASTER EQUIPMENT LEASE AGREEMENT NO. 0135 ("Amendment")
is dated as of April 3, 1998, by and between SEQUENOM, INC. ("Lessee") and
PHOENIX LEASING INCORPORATED ("Lessor").

                                    RECITALS
                                    --------

WHEREAS, Lessee and Lessor entered into that certain Master Equipment Lease
Agreement No. 0135, dated as of February 5, 1998 (the "Lease"), pursuant to
which Lessee is leasing or intends to lease equipment with an aggregate purchase
price of $1,500,000 (the "Initial Commitment");

WHEREAS, Lessee has requested that Lessor increase dollar limit on Soft Costs
which Lessor is willing to lease to Lessee under the Lease to 30% of the
utilized line, (such increase hereinafter referred to as the "Additional
Commitment");

WHEREAS, Lessor is willing to provide for such increase, on the terms set forth
herein and Lessee is willing to agree to such terms; and

WHEREAS, Lessee and Lessor now desire to amend the Lease to provide for the
increase in Soft Cost Financing, and as otherwise provided in this Amendment;

NOW, THEREFORE, IT IS AGREED THAT:

1.   Definitions. Unless otherwise indicated, words and terms which are defined
     ------------
in the Lease shall have the same meaning where used herein.  Upon execution of
this Amendment, (i) the term "Lease" shall be deemed to include this Amendment.

2.   Amendments.  The Lease is hereby amended as follows:
     ----------

     (a)  Section 3(a) is amended by deleting reference to 15% and inserting
          reference to 30% in lieu thereof.

     (b)  A second and third paragraph is added to Section 3 as follows:

          (c)  Specific Terms - Soft Costs.  Lessee and Lessor agree that if, on
               ---------------------------
February 12, 1999, the amount funded allocable to Soft Costs exceeds twenty
percent (20%) of the Commitment utilized as of such expiration date, then, at
Lessor's option, Lessee shall pay to Lessor a cash amount equal to such excess
("Excess Payment").  Lessee agrees to pay the Excess Payment to Lessor within
thirty (30) days of Lessor's invoice to be held and applied by Lessor in
accordance with the following paragraph.

          Provided (a) no Event of Default under the Lease has occurred or is
continuing, (b) Lessor is satisfied that Lessee has theretofore continuously
performed according to its Business Plan and (c) Lessor has timely received from
Lessee all Monthly Rental Payments, (as defined in the Schedule) then Lessor
shall apply any Excess Payment to Lessee's End of Lease Position requirement
described in the Schedule by applying the Excess Payment pro rata under

                                       18
<PAGE>

each Schedule to Election No. 1, if Lessee elects Election No. 1, or pro rata to
Monthly Rental Payments due under the extension of each Schedule if Lessee
elects Election No. 2 in reverse order of maturities.

     (c)  Section 18(b) is amended by adding at the end thereof the following
sentence:

          In addition to the foregoing remedies, Lessor may apply the Excess
Payment, as herein defined, (1) to compensate Lessor for losses or damages
sustained as a result of such Event of Default; and/or (2) to reimburse Lessor
for costs and expenses, including reasonable attorney's fees, incurred by Lessor
in connection with such failure to perform, whether or not litigation or other
judicial proceedings are commenced.  Any surplus remaining thereafter shall be
retained by Lessor as security hereunder.

3.   Representations and Warranties.  Lessee hereby reconfirms as of the date
     ------------------------------
hereof, its representations and warranties set forth in Section 5 of the Lease.

4.   Continued Validity of Lease.  Except as amended by this Amendment, the
     ---------------------------
Lease shall continue in full force and effect as originally constituted and is
ratified and affirmed by the parties hereto. Such Amendment shall not amend or
otherwise affect any of the Schedules executed and delivered by Lessee prior to
the date hereof.

5.   Authorization.  Each party represents to the other that the individual
     -------------
executing this Amendment on its behalf is the duly appointed signatory of such
party to this Amendment and that such individual is authorized to execute this
Amendment by or on behalf of such party and to take all action required by the
terms of this Amendment.

6.   When Amendment is Effective.  This Amendment shall be binding and deemed
     ---------------------------
effective when executed by Lessee and accepted and executed by Lessor.  Upon
such effectiveness this Amendment shall be deemed to have amended the Lease as
provided herein.

7.   Captions.  Section headings and numbers have been set forth herein for
     --------
convenience only.  Unless the contrary is compelled by the context, everything
contained in each section applies equally to this entire Amendment.

8.   No Novation.  This Amendment is not intended to be, and shall not be
     -----------
construed to create, a novation or accord and satisfaction and, except as
otherwise provided herein, the Lease shall remain in full force and effect.

9.   Severability.  Each provision of this Amendment shall be severable from
     ------------
every other provision of this Amendment for the purpose of determining the legal
enforceability of any specific provision.

10.  Entire Agreement.  The Lease as amended by this Amendment constitutes the
     ----------------
entire agreement between Lessee and Lessor with respect to the subject matter
hereof and supersedes all prior and contemporaneous negotiations,
communications, discussions and agreements

                                       19
<PAGE>

concerning such subject matter. Lessee acknowledges and agrees that Lessor has
not made any representation, warranty or covenant in connection with this
Amendment.

11.  Conflicts.  In the event of any conflict between the terms of this
     ---------
Amendment and terms of the Master Equipment Lease Agreement No. 0135, the terms
of this Amendment shall prevail.

IN WITNESS WHEREOF, the parties hereto have executed and delivered this
Amendment as of the date first set forth above.

- --------------------------------------------------------------------------------
LESSOR:                                     LESSEE:

PHOENIX LEASING INCORPORATED                SEQUENOM, INC.

By:     /s/  Lynn Sanders                   By:     /s/  Stephen Zaniboni
   -------------------------------             -------------------------------

Name:     Lynn Sanders                      Name (Print):   Stephen Zanziboni
     -----------------------------                       ---------------------

Title:     Contract Administrator           Title:     VP Finance
      ----------------------------                ----------------------------

- --------------------------------------------------------------------------------

                                       20
<PAGE>

PHOENIX GROWTH                                                Thomas K. Morrison
CAPITAL CORP.                                                     Vice President
A Phoenix American Company

                                    [LOGO]
- --------------------------------------------------------------------------------

                                               3000 Sand Hill Road
                                               Building 1, Suite 160
                                               Menlo Park, California 91025-7116
                                               (650) 854-8404
                                               (650) 854-5732 FAX
                                               [email protected]

October 22, 1998

Mr. Steve Zaniboni
Vice President, Finance & Administration
Sequenom Inc.
I i555 Sorrento Valley Road
San Diego, CA 92121

Dear Steve:

We are pleased to provide this commitment for an extension of your equipment
lease line under the following terms and conditions.

FACILITY
- --------

     Finance Lease

PARTIES TO THE TRANSACTION
- --------------------------

     1.   Lessee:  Sequenom Inc.
          ------

     2.   Lessor:  Phoenix Growth Capital Corp. (PGCC), its Affiliates or
          ------
          Assigns.

EQUIPMENT
- ---------

     1.   Total Cost:  $600,000 additional, for a total of up to $2,100,000
          ----------

     2.   Equipment Description:  Laboratory and manufacturing equipment for
          ---------------------
          automated process line per list provided.  Up to 20% of the utilized
          line may be used for soft cost items, defined as exclusions below.

          a.   Exclusions:  Custom use equipment, installation and delivery
               ----------
               costs, purchase tax. tooling, software, tenant improvements off-
               premises equipment and items generally considered fungible or
               expendable.

          b.   Used Equipment:  Lessor will provide lease financing for
               --------------
               acceptable used equipment.  Equipment purchased by Lessee prior
               to 180 days before completion of lease documentation is subject
               to adequate depreciation allowances.
<PAGE>

Mr. Steve Zaniboni
October 22, 1998
Page 2

     3.   Deliveries:  All equipment to be purchased by Lessor must be
          ----------
          delivered, accepted and funded no later than August 31. 1999.

     4.   Equipment Location:  Same as above.
          ------------------

TRANSACTION STRUCTURE
- ---------------------

     The Lessor will purchase the equipment from the Lessee or the vendor (after
     delivery) and simultaneously lease the equipment to the Lessee.

     A finance lease document will evidence the agreement between the Lessor and
     Lessee.  It is anticipated that the lease will be a Master Lease with
     schedules evidencing takedowns.  All base Master Lease documentation must
     be completed within four weeks of the date a commitment letter has been
     signed by both parties.

LEASE INFORMATION
- -----------------

     1.   Base Lease Term Commencement Date:  The Base Lease Term will commence
          ---------------------------------
          on the First of the month.  If funding is other than the first of the
          month, commencement date will be the first of the following month.

     2.   Base Lease Term(s):  The Base Lease Term will be 42 months from the
          ------------------
          Base Lease Term Commencement Date.

     3.   Delivery and Acceptance:  All equipment delivered and placed in
          -----------------------
          service will be acknowledged and accepted by the Lessee per a written
          Acceptance Notice.

     4.   Financial Closing Date(s): The equipment will be paid for by the
          -------------------------
          Lessor on a monthly basis in aggregate amounts not less than $25,000.

     5.   Interim Rent:  An interim Lease term will run from the date each
          ------------
          equipment schedule is funded by the Lessor until the Base Lease Term
          Commencement Date.

     6.   Lease Rate Factor:  42 months at 2.72%, last payable in advance.
          -----------------

     7.   End of Lease Position:  At lease expiration, the Lessee will either
          ---------------------
          (a) purchase the equipment for 25% or (b) renew the Lease for an
          additional 12 months at 2.50% per month and then own the equipment for
          payment of $1.00.

     8.   Soft Costs:  Soft costs may be as much as 30% of the utilized line
          ----------
          during the commitment period.  If soft costs exceed 20% of the
          utilized line at the end of the commitment period, or in the event of
          a material adverse change in Lessee's performance to plan or business
          condition, Lessee agrees to pay Lessor a single payment sufficient to
          bring the percentage of soft costs to 20%.  Such payment would be
          applied to the end of lease payment first, and then to payments due
<PAGE>

Mr. Steve Zaniboni
October 22, 1998
Page 3

          under the Lease in reverse order.  Alternatively, PGCC may at its
          option extend the commitment period to provide Lessor with additional
          time to take down equipment sufficient to restore the 20% proportion.

     9.   Adjust-A-Lease:  Lessee may make additions to existing equipment or
          --------------
          replace existing equipment during the Lease term subject to credit and
          equipment review and approval.

     10.  Casualty values (Stipulated Loss Values):  In the event the equipment
          ----------------------------------------
          is destroyed or otherwise rendered permanently unfit for service, and
          is not repaired or replaced by Lessee or its insurance carrier, the
          Lessee will pay a Casualty Value.  The Casualty Values will be
          calculated at the outset of the transaction and will dictate the
          amount of the Lessee's casualty insurance coverage.

OTHER CONSIDERATIONS
- --------------------

     1.   Net Lease:  The lease will be net to the Lessor.  Lessee will be
          ---------
          responsible for all expenses in connection with the equipment,
          including taxes (except taxes based on the income of the Lessor),
          franchise taxes, charges in lieu of taxes, assessments, insurance
          premiums, all costs of operations, repair, maintenance and rebuilding,
          and all of the charges related to the equipment or its operation.

     2.   Transaction Expense:  Each party shall bear its own expenses,
          -------------------
          including fees and expenses of counsel and accountants, incurred in
          connection with the documentation and preparation of this lease
          transaction, except UCC, equipment identification and appraisal costs,
          which will be bore by Lessee.  However, if this transaction is not
          funded because Lessee (a) fails to execute final documents with
          Lessor, (b) chooses not to use the committed lease amounts, or (c)
          sustains a material adverse change in its financial condition, Lessor
          shall retain the commitment fee as compensation for expenses.

     3.   Stock Warrants:  None.
          --------------

     4.   Additional Collateral or Technology/Patent Lien:  None
          -----------------------------------------------

     5.   Negative Restrictive Covenants:  None
          ------------------------------

     6.   Commitment Fee:  Lessee has paid to Lessor a commitment fee of $2,500.
          --------------
          The fee shall be applied by Lessor first to reimburse any Transaction
          Expenses shown above and then proportionally to the first payment due
          for each schedule hereunder.

     7.   Financial Information:  Lessee must provide interim financial
          ---------------------
          information (balance sheet, income statement, funds flow and changes
          to projections) when available monthly after a commitment letter has
          been signed by both parties.
<PAGE>

Mr. Steve Zaniboni
October 22, 1998
Page 4

     8.   Conditions Precedent:  No material adverse performance to plan.
          --------------------
          PGCC's "exposure", defined as amounts funded less payments received,
          not to exceed $2,000,000 at any point in time.

If you are in agreement with the foregoing, please sign and date one copy of
this commitment letter and return it to my attention by FAX at 415-485-4663.
Thank you.

Sincerely,                          Acknowledge and Agreed to:


                                    By:   /s/ Stephen Zaniboni
                                        ------------------------

/s/ Thomas K. Morrison

Thomas K. Morrison                  Its:   VP Finance
Vice President                          ------------------------


                                    Date:    11/16/98
                                          ----------------------
<PAGE>

                                   SCHEDULE
                                   --------

                              Schedule No. 01 to Lease
                              Dated as of February 5, 1998
                              Between SEQUENOM, INC.
                              and PHOENIX LEASING INCORPORATED

A.  Description and Purchase Price of Equipment
    -------------------------------------------

<TABLE>
<CAPTION>
            Description of
              Equipment
           (quantity, model             Purchase                        Mfr./             Street Address
          and serial number)             Price            Rent         Vendor        City, State and County
          ------------------             -----            ----         ------        ----------------------
        <S>                          <C>              <C>              <C>           <C>
          See Exhibit A attached hereto.
              Total:                 $219,994.40      $5,983.85
</TABLE>

B.   Terms
     -----

Base Term:          The Base Term shall commence on the date the Equipment is
                    received, installed and accepted for use, as shown on the
                    Acceptance Notice, and continue for 42 full months after the
                    "Rent Start Date."

Rent Start Date:    This shall be the first day of the month following the month
                    during which the Base Term commences; provided, however,
                    that if the Equipment is accepted on the first day of the
                    month, the Rent Start Date shall commence on the same day
                    that the Base Term commences.

Lease Rate Factor (expressed as a percentage of Equipment's original Purchase
Price):  2.72%

Monthly Rental Payments in advance.

Base Rent Due:      Payable on the Rent Start Date shall be (1) the first and
                    last Rental Amount including any sales or use tax and (2) an
                    amount equal to 1/30th of the monthly rental amount using a
                    rate of 2.72% multiplied by the number of days, if any,
                    between (and including) the date the Base Term commences and
                    (but not including) the Rent Start Date, except that, if the
                    date of the Acceptance Notice related to this Schedule is
                    dated on or after the 20th of the month, this amount shall
                    not be included in the Base Rent Due.

C.   Invoice Information:  Lessee's and Lessor's addresses for invoice purposes
     -------------------
for the Equipment on the Schedule shall be as follows:

Lessee's Invoice Address:                       Remit Monthly Rental Amount To:
- ------------------------                        -------------------------------
SEQUENOM, INC.                                  PHOENIX LEASING INCORPORATED
11555 Sorrento Valley Road                      P.O. Box 200432
San Diego, CA  92121                            Dallas, TX  75320-0432
Attention:  Mr. Steve Zaniboni, Vice President, Finance and Administration

D.  Casualty Values:  See attachment hereto.
    -------- ------

                                       1
<PAGE>

                              Schedule No. 01 to Lease
                              Dated as of February 5, 1998
                              Between SEQUENOM, INC.
                              and PHOENIX LEASING INCORPORATED

E.  Special Provisions:  1.  Lessor's payment for Equipment hereunder is
    ------- ----------
conditioned on Lessor's satisfaction of the conditions set forth in Section 3 of
the Lease and 2. Sale Leaseback Addendum.

F.  End of Lease Position:  (a)  General.  Lessee shall be required to choose a
    --- -- ----- --------        -------
final purchase or extension requirement ("End of Lease Position") at the
expiration of the Base Term (as defined in the Schedule) of the first Schedule
to the Lease.  That choice shall be an election of Lessee's End of Lease
Position for all, but not less than all, of the Equipment under all Schedules to
the Lease.  Lessee shall provide written notice of its election to Lessor at
least 90 days prior to the end of the Base Term of the first Schedule.

Any Equipment purchase election shall be a purchase of the Equipment, AS-IS,
WHERE-IS.  Upon Lessor's receipt of the purchase price, Lessor shall issue to
Lessee an equipment bill of sale, transferring title to the Equipment to the
Lessee without any representation or warranty whatsoever.  Lessee shall be
responsible for all applicable taxes in connection with any Equipment purchase.

In the event Lessee does not provide at least 90 days' prior written notice of
its election, Lessee shall be deemed to have elected Election No. 2.

At the expiration of the Base Term of the first Schedule Lessee shall be
required to elect to either:

Election No. 1:  Purchase the Equipment for 25% of the Equipment's original
- -------- --  -
purchase price; or

Election No. 2:  Extend the Schedule's Base Term for an additional 12 months
- -------- --  -
("Extended Term") for a monthly rate of 2.50% of the Equipment's original
purchase price.

At the expiration of the Extended Term, Lessee shall purchase the Equipment for
$1.00.

LESSOR AND LESSEE AGREE THAT THIS SCHEDULE SHALL CONSTITUTE A LEASE OF THE
EQUIPMENT DESCRIBED ABOVE, SUBJECT TO THE TERMS AND CONDITIONS OF THIS SCHEDULE
AND OF THE MASTER EQUIPMENT LEASE DATED FEBRUARY 5, 1998 BETWEEN LESSEE AND
LESSOR.  THE TERMS AND CONDITIONS OF SUCH MASTER EQUIPMENT LEASE ARE HEREBY
INCORPORATED BY REFERENCE AND MADE A PART HEREOF TO THE SAME EXTENT AS IF SUCH
TERMS AND CONDITIONS WERE SET FORTH IN FULL HEREIN.

LESSOR:                                    LESSEE:

PHOENIX LEASING INCORPORATED               SEQUENOM, INC.

By:  /S/ (ILLEGIBLE)                       By:  /S/ STEPHEN ZANIBONI
   --------------------------------           --------------------------------
Name:   (ILLEGIBLE)                        Name (Print):   STEPHEN ZANIBONI
     ------------------------------                     ----------------------
Title:    (ILLEGIBLE)                      Title:   VP FINANCE
      -----------------------------              -----------------------------
Date:  2/26/98                             Date:  2/12/98
     ------------------------------             ------------------------------

                                       2
<PAGE>

                    ATTACHMENT TO EQUIPMENT SCHEDULE NO. 01

                                CASUALTY VALUE

<TABLE>
<CAPTION>
 Month of         % of Original Equipment    Month of    % of Original Equipment
Lease Term             Purchase Price       Lease Term       Purchase Price
- ----- ----             -------- -----       ----- ----       -------- -----
<S>               <C>                       <C>          <C>
     1                     125.00               22                73.78
     2                     122.56               23                71.34
     3                     120.12               24                68.90
     4                     117.68               25                66.46
     5                     115.24               26                64.02
     6                     112.80               27                61.59
     7                     110.37               28                59.15
     8                     107.93               29                56.71
     9                     105.49               30                54.27
    10                     103.05               31                51.83
    11                     100.61               32                49.39
    12                      98.17               33                46.95
    13                      95.73               34                44.51
    14                      93.29               35                42.07
    15                      90.85               36                39.63
    16                      88.41               37                37.20
    17                      85.98               38                34.76
    18                      83.54               39                32.32
    19                      81.10               40                29.88
    20                      78.66               41                27.44
    21                      76.22               42                25.00
                                            Thereafter            25.00
</TABLE>

  Lessor's                                      Lessee's
  Initials (ILLEGIBLE)                          Initials (ILLEGIBLE)
           -----------                                   -----------
<PAGE>

                               ACCEPTANCE NOTICE

                                SCHEDULE NO. 01

Reference is made to the Master Equipment Lease dated as of February 5, 1998
between PHOENIX LEASING INCORPORATED as Lessor and SEQUENOM, INC. as Lessee (the
"Lease").

Lessee confirms that the following Equipment has been received, installed and is
ready for use by Lessee.  The Equipment is satisfactory in all respects for the
purposes of this Lease as of the date Lessee executes this Notice below.

<TABLE>
<CAPTION>
     Description of Equipment
        (quantity, model         Purchase                Mfr./       Street Address
        and serial number)        Price       Rent      Vendor    City, State and County
        ------------------        -----       ----      ------    ----------------------
     <S>                      <C>          <C>          <C>       <C>
See Exhibit A attached hereto.


         Total:               $219,994.40  $5,983.85
</TABLE>


THE LEASE MAY NOT BE CHANGED, ALTERED OR MODIFIED EXCEPT BY AN INSTRUMENT IN
WRITING SIGNED BY AN OFFICER OF LESSOR AND A DULY AUTHORIZED REPRESENTATIVE OF
LESSEE.

IN WITNESS WHEREOF, Lessee has executed this Acceptance Notice as of February
25, 1998.

                                        SEQUENOM, INC.

                                        By:  /S/ STEPHEN ZANIBONI
                                           -------------------------------

                                        Name:  STEPHEN ZANIBONI
                                             -----------------------------

                                        Title:  VP FINANCE
                                              ----------------------------
<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A

     Lessee: SEQUENOM, INC.
             ---------------------
             11555 SORRENTO VALLEY RD.
             SAN DIEGO, CA  94121

<TABLE>
<CAPTION>
Master Contract:  0135                                                                                    Schedule:  01
                --------                                                                                           -------

- --------------------------------------------------------------------------------------------------------------------------------
                                                                                              Invoiced
Vendor Name           Invoice      Brief Description        Eqp                             Amt Net of     Amt Paid      Tax Pd
(abbreviation OK)     No.          of Item                  Code    Serial Number    LOC     Sales Tax    by Lessee     (______)
- --------------------------------------------------------------------------------------------------------------------------------
<S>                   <C>          <C>                      <C>     <C>              <C>    <C>           <C>           <C>
Beckman Instrmts      331062FT01   Pipellor Ensemble          2     304017APS         1      46,360.50                      N
- --------------------------------------------------------------------------------------------------------------------------------

- --------------------------------------------------------------------------------------------------------------------------------
                                   Freight & Insurance       27                       1         696.16                      N
- --------------------------------------------------------------------------------------------------------------------------------
                      331062FT02   Dsposble Tip Wash Sys.     2     90006             1       5,500.00                      N
- --------------------------------------------------------------------------------------------------------------------------------

- --------------------------------------------------------------------------------------------------------------------------------
                                   Freight & Insurance       27                       1         142.68                      N
- --------------------------------------------------------------------------------------------------------------------------------
MJ Research, Inc.      43466       PTC-0225 Tefrad Chssis    26     TD002536          2      14,245.25                      N
- --------------------------------------------------------------------------------------------------------------------------------
                                   ALP-1296 Alpha/Power      26     ALO13185/         2       3,955.60                      N
- --------------------------------------------------------------------------------------------------------------------------------
                                   Bonnet 200/225            26     PB0361            2                                     N
- --------------------------------------------------------------------------------------------------------------------------------
                                   ALP-1296 Alpha/Power      26     AL01402B          2       3,955.50                      N
- --------------------------------------------------------------------------------------------------------------------------------
                                   Bonnet 200/225            26     PB0361            2                                     N
- --------------------------------------------------------------------------------------------------------------------------------
                                   ALP-1296 Alpha/Power      26     AL014038/         2       3,955.50                      N
- --------------------------------------------------------------------------------------------------------------------------------
                                   Bonnet 200/225            26     PB0371            2       3,955.50                      N
- --------------------------------------------------------------------------------------------------------------------------------
                                   ALP-1296 Alpha/Power      26     AL014041/         2                                     N
- --------------------------------------------------------------------------------------------------------------------------------
                                   Bonnet 200/225            26     PB0340            2                                     N
- --------------------------------------------------------------------------------------------------------------------------------

- --------------------------------------------------------------------------------------------------------------------------------
                                   Freight                   27                       2         105.00                      N
- --------------------------------------------------------------------------------------------------------------------------------
                       43377       PTC-0225 Tetra Chssis      2     TD002426          1      14,245.25                      N
- --------------------------------------------------------------------------------------------------------------------------------
                                   ALP-1296 Alpha/Power       2     ALO14021/         1       3,955.50                      N
- --------------------------------------------------------------------------------------------------------------------------------
                                   Bonnet 200/225             2     PB0369            1                                     N
- --------------------------------------------------------------------------------------------------------------------------------
                                   ALP-1296 Alpha/Power       2     ALO14023/         1       3,955.50                      N
- --------------------------------------------------------------------------------------------------------------------------------
                                   Bonnet 200/225             2     PB0369            1                                     N
- --------------------------------------------------------------------------------------------------------------------------------
                                   ALP-1296 Alpha/Power       2     ALO14025/         1       3,955.50                      N
- --------------------------------------------------------------------------------------------------------------------------------
                                   Bonnet 200/225             2     PB0359            1                                     N
- --------------------------------------------------------------------------------------------------------------------------------
                                   ALP-1296 Alpha/Power       2     ALO14030/         1       3,955.50                      N
- --------------------------------------------------------------------------------------------------------------------------------
                                   Bonnet 200/225             2     PB0358            1                                     N
- --------------------------------------------------------------------------------------------------------------------------------

- --------------------------------------------------------------------------------------------------------------------------------
                                   freight                   27                       1         122.00                      N
- --------------------------------------------------------------------------------------------------------------------------------
PE Biosystems       90056171       DNA SYS 4 COL/8BASE        2     394-              1      37,000.00                      N
- --------------------------------------------------------------------------------------------------------------------------------

<CAPTION>
- ---------------------------------------------------------------------------------------------------------
                                                                         No entry required
                                                                    -------------------------------------
Vendor Name           Invoice          Check       Transact          Net $ Amt       Net $ Amt.
(abbreviation OK)     No.               No.          Date           Due Lessee       Due Vendor
- ---------------------------------------------------------------------------------------------------------
<S>                   <C>              <C>         <C>              <C>              <C>
Beckman Instrmts      331062FT01                                         $0.00       $46,360.50        N
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $     0.00     #N/A
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $   696.16        N
- ---------------------------------------------------------------------------------------------------------
                      331062FT02                                         $0.00       $ 5,580.00        N
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $     0.00     #N/A
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $   142.68     #N/A
- ---------------------------------------------------------------------------------------------------------
MJ Research, Inc.      43466                                             $0.00       $14,245.25        N
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $ 3,955.50        N
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $     0.00     #N/A
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $ 3,955.50     #N/A
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $     0.00        N
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $ 3,955.50        N
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $     0.00        N
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $ 3,955.50        N
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $     0.00        N
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $     0.00     #N/A
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $   105.00        N
- ---------------------------------------------------------------------------------------------------------
                       43377                                             $0.00       $14,245.25        N
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $ 3,955.50        N
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $     0.00        N
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $ 3,955.50     #N/A
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $     0.00     #N/A
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $ 3,955.50     #N/A
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $     0.00     #N/A
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $ 3,955.50        N
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $     0.00     #N/A
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $     0.00
- ---------------------------------------------------------------------------------------------------------
                                                                         $0.00       $   122.00        N
- ---------------------------------------------------------------------------------------------------------
PE Biosystems       90056171                                             $0.00       $37,000.00        N
- ---------------------------------------------------------------------------------------------------------
</TABLE>

                                  Page 1 of 3
                   Property of Phoenix Leasing Incorporated
<PAGE>

<TABLE>
<S>              <C>          <C>                     <C>     <C>             <C>  <C>         <C>         <C>  <C>     <C>
- --------------------------------------------------------------------------------------------------------------------------------
                              & Kit                    2       100000004J     1                            N
- --------------------------------------------------------------------------------------------------------------------------------

- --------------------------------------------------------------------------------------------------------------------------------
                              Freight                 27                      1      286.38                N
- --------------------------------------------------------------------------------------------------------------------------------
Micron           1534719      Cmplr ATO Model BOM      1     1088241-0001     1    2,597.00                N
- --------------------------------------------------------------------------------------------------------------------------------

- --------------------------------------------------------------------------------------------------------------------------------
                              Freight                 27                      1       99.00                N
- --------------------------------------------------------------------------------------------------------------------------------
Necx             560093N      Visual C++ V5.0 Pro     24        59819-811-    1      429.95                N
- --------------------------------------------------------------------------------------------------------------------------------
                              95/NT CD                 2          2088451-    1                            N
- --------------------------------------------------------------------------------------------------------------------------------
                                                       2            85206     1                            N
- --------------------------------------------------------------------------------------------------------------------------------
                              Freight                 27                      1        3.95                N
- --------------------------------------------------------------------------------------------------------------------------------
                 564237N      Deskjet 890CXI PC 600    1       US77Q120DX     1      424.95                N
- --------------------------------------------------------------------------------------------------------------------------------
                              Freight                 27                      1       12.91                N
- --------------------------------------------------------------------------------------------------------------------------------
Micron           1591926      Cmplr Laptop System      1     1110980-0001     1    3,467.00                N
- --------------------------------------------------------------------------------------------------------------------------------

- --------------------------------------------------------------------------------------------------------------------------------
                              Freight                 27                      1       47.68                N
- --------------------------------------------------------------------------------------------------------------------------------
                 1416281      Cmplr ATO Model BOM      1     1032255/0001     1    3,647.00    3,647.00    Y    2105    11/25/97
- --------------------------------------------------------------------------------------------------------------------------------
                              Cmplr ATO Model BOM      1     1033255/0002     1    3,647.00    3,647.00    Y    2105    11/25/97
- --------------------------------------------------------------------------------------------------------------------------------

- --------------------------------------------------------------------------------------------------------------------------------
                              Freight                 27                      1      258.00      258.00    Y    2105    11/25/97
- --------------------------------------------------------------------------------------------------------------------------------
Necx              517431      LifeBook 735 clx 133     1                      1    1,879.95    1.879.95    N    2128    11/30/97
- --------------------------------------------------------------------------------------------------------------------------------
                              Freight                 27                      1       15.75       15.75    N    2128    11/30/97
- --------------------------------------------------------------------------------------------------------------------------------
Micron           1477538      Cmptr ATO Model BOM      1      1058058-001     1    2,067.00    2,067.00    Y    2157    12/20/97
- --------------------------------------------------------------------------------------------------------------------------------

- --------------------------------------------------------------------------------------------------------------------------------
                              Freight                 27                      1      119.00      119.00    Y    2157    12/20/97
- --------------------------------------------------------------------------------------------------------------------------------
                 1513020      Cmptr ATO Model BOM      1     1076930-0001     1    3,547.00    3,547.00    Y    2216    12/29/97
- --------------------------------------------------------------------------------------------------------------------------------

- --------------------------------------------------------------------------------------------------------------------------------
                              Freight                 27                      1      119.00      119.00    Y    2216    12/29/97
- --------------------------------------------------------------------------------------------------------------------------------
                 1513022      Cmptr ATO Model BOM      1     1076996-0001     1    3,836.00    3,836.00    Y    2216    12/29/97
- --------------------------------------------------------------------------------------------------------------------------------

- --------------------------------------------------------------------------------------------------------------------------------
                              Freight                 27                      1        0.00        0.00    Y    2216    12/29/97
- --------------------------------------------------------------------------------------------------------------------------------
                 1515296      Cmptr ATO Model BOM      1     1076945-0001     1    2,438.00    2,438.00    Y    2216    12/29/97
- --------------------------------------------------------------------------------------------------------------------------------

- --------------------------------------------------------------------------------------------------------------------------------
                              Freight                 27                      1       99.00       99.00    Y    2216    12/29/97
- --------------------------------------------------------------------------------------------------------------------------------
Necx              540370      LifePro 720 LCD Prjctr  17        AG7483316     1    5,699.95    5,699.95    N    2229    12/30/97
- --------------------------------------------------------------------------------------------------------------------------------
                              Freight                 27                      1       14.95       14.95    N    2229    12/30/97
- --------------------------------------------------------------------------------------------------------------------------------
Oracle            918340      Oracle for Window NT    24        A54496-01     1    1,327.50    1,327.50    Y    2069    11/13/97
- --------------------------------------------------------------------------------------------------------------------------------

- --------------------------------------------------------------------------------------------------------------------------------
Biorad             75441      Chem Window             24       UEW1019188     1      599.00      599.00    Y    2044    11/10/97
- --------------------------------------------------------------------------------------------------------------------------------

<CAPTION>
<S>              <C>            <C>           <C>          <C>
                                $    0.00     $    0.00    #N/A
- ---------------------------------------------------------------
                                $    0.00     $    0.00       N
- ---------------------------------------------------------------
                                $    0.00     $  286.38       N
- ---------------------------------------------------------------
Micron           1534719        $    0.00     $2,597.00       N
- ---------------------------------------------------------------
                                $    0.00     $    0.00
- ---------------------------------------------------------------
                                $    0.00     $   99.00       N
- ---------------------------------------------------------------
Necx             560093N        $    0.00     $  429.95       N
- ---------------------------------------------------------------
                                $    0.00     $    0.00       N
- ---------------------------------------------------------------
                                $    0.00     $    0.00       N
- ---------------------------------------------------------------
                                $    0.00     $    3.95       N
- ---------------------------------------------------------------
                 564237N        $    0.00     $  424.95       N
- ---------------------------------------------------------------
                                $    0.00     $   12.91       N
- ---------------------------------------------------------------
Micron           1591926        $    0.00     $3,467.00       N
- ---------------------------------------------------------------
                                $    0.00     $    0.00    #N/A
- ---------------------------------------------------------------
                                $    0.00     $   47.68       N
- ---------------------------------------------------------------
                 1416281        $3,647.00     $    0.00       N
- ---------------------------------------------------------------
                                $3,647.00     $    0.00       N
- ---------------------------------------------------------------
                                $    0.00     $    0.00       N
- ---------------------------------------------------------------
                                $  258.00     $    0.00       N
- ---------------------------------------------------------------
Necx              517431        $1,879.95     $    0.00       N
- ---------------------------------------------------------------
                                $   15.75     $    0.00       N
- ---------------------------------------------------------------
Micron           1477538        $2,067.00     $    0.00       N
- ---------------------------------------------------------------
                                $    0.00     $    0.00    #N/A
- ---------------------------------------------------------------
                                $  119.00     $    0.00       N
- ---------------------------------------------------------------
                 1513020        $3,547.00     $    0.00       N
- ---------------------------------------------------------------
                                $    0.00     $    0.00       N
- ---------------------------------------------------------------
                                $  119.00     $    0.00       N
- ---------------------------------------------------------------
                 1513022        $3,836.00     $    0.00       N
- ---------------------------------------------------------------
                                $    0.00     $    0.00    #N/A
- ---------------------------------------------------------------
                                $    0.00     $    0.00       N
- ---------------------------------------------------------------
                 1515296        $2,438.00     $    0.00       N
- ---------------------------------------------------------------
                                $    0.00     $    0.00       N
- ---------------------------------------------------------------
                                $   99.00     $    0.00       N
- ---------------------------------------------------------------
Necx              540370        $5,699.95     $    0.00       N
- ---------------------------------------------------------------
                                $   14.95     $    0.00       N
- ---------------------------------------------------------------
Oracle            918340        $1,327.50     $    0.00       N
- ---------------------------------------------------------------
                                $    0.00     $    0.00    #N/A
- ---------------------------------------------------------------
Biorad             75441        $  599.00     $    0.00       N
- ---------------------------------------------------------------
</TABLE>

                                  Page 2 of 3
                   Property of Phoenix Leasing Incorporation
<PAGE>

<TABLE>
<CAPTION>
<S>                   <C>          <C>                       <C> <C>          <C> <C>       <C>       <C> <C>   <C>        <C>
- ------------------------------------------------------------------------------------------------------------------------------------
                                   Chem Window               24   UEW1019175  1     999.00    999.00  Y   2044  11/10/97   $  999.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                                             24       SUITES  1                       Y   2044  11/10/97   $    0.00
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
                                   Freight                   27               1      10.00     10.00  Y   2044  11/10/97   $   10.00
- ------------------------------------------------------------------------------------------------------------------------------------
Necx                               Credit Card Either Adpt.  24            ?  1     127.95    127.95  N   2148   12/5/97   $  127.95
- ------------------------------------------------------------------------------------------------------------------------------------
                                   Visual C++ V5.0 Pro       24    59819-809  1     429.95    429.95  N   2158  12/10/97   $  429.95
- ------------------------------------------------------------------------------------------------------------------------------------
                                   95/NT CD                  24      2464685  1                       N   2158  12/10/97   $    0.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                   Freight                   27               1       3.95      3.95  N   2158  12/10/97   $    3.95
- ------------------------------------------------------------------------------------------------------------------------------------
                      541316N      Visual Basic V5.0 Pro     24  203-056-016  1     429.95    429.95  N   2242  12/31/97   $  429.95
- ------------------------------------------------------------------------------------------------------------------------------------
                                   Freight                   27               1       5.95      5.95  N   2242  12/31/97   $    5.95
- ------------------------------------------------------------------------------------------------------------------------------------
Isec                  97093022     Fume Hood                  2    016070690  1   8,100.00  8,100.00  Y    VAR    1/8/98   $8,100.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                   Fume Hood                  2    016070691  1   8,100.00  8,100.00  Y    VAR    1/8/89   $8,100.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                   Solvent Cabinets           2               1   2,148.00  2,148.00  Y    VAR    1/8/98   $2,148.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                   Fume Hood Prepping         2               1     700.00    700.00  Y    VAR    1/8/98   $  700.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                           $    0.00
- ------------------------------------------------------------------------------------------------------------------------------------
Uniequip              978092       Concentrator Cntrfuge      2    976034714  1   3,140.00  3,140.00  N   Wire  10/20/97   $3,140.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                   Aspstor Vacuum Pump        2    976034838  1   3,370.00  3,370.00  N   Wire  10/20/97   $3,370.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                   Freight                   27               1     308.74    308.74  N   Wire  10/20/97   $  308.74
- ------------------------------------------------------------------------------------------------------------------------------------
MJ Research, inc.     42107        ALD-1233 Dual Alpha        2     AL012491  1   2,370.25  2,370.25  Y   2106  11/25/97   $2,370.25
- ------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                           $    0.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                   Freight                   27               1      16.00     16.00  Y   2106  11/25/97   $   16.00
- ------------------------------------------------------------------------------------------------------------------------------------
Pfeiffer Vacuum       268868       PKR250 Guage 40KF          2     2416V015  1     653.90    653.90  Y   2219  12/29/97   $  653.90
- ------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                           $    0.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                   Freight                   27               1      12.00     12.00  Y   2219  12/29/97   $   12.00
- ------------------------------------------------------------------------------------------------------------------------------------
Simco Products        0014780-IN   HP 450C Inkjet Printer     1   ESA7905454  1   1,795.00  1,795.00  Y   2234  12/30/97   $1,795.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                   Roll Feed D                1               1     225.00    225.00  Y   2234  12/30/97   $  225.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                   D Size Legs                1               1     225.00    225.00  Y   2234  12/30/97   $  225.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                           $    0.00
- ------------------------------------------------------------------------------------------------------------------------------------

<CAPTION>
<S>                   <C>          <C>                         <C>        <C>
- ---------------------------------------------------------------------------------------
                                   Chem Window                 $  0.00              N
- ---------------------------------------------------------------------------------------
                                                               $  0.00              N
- ---------------------------------------------------------------------------------------
- ---------------------------------------------------------------------------------------
                                   Freight                     $  0.00           #N/A
- ---------------------------------------------------------------------------------------
Necx                               Credit Card Either Adpt.    $  0.00              N
- ---------------------------------------------------------------------------------------
                                   Visual C++ V5.0 Pro         $  0.00              N
- ---------------------------------------------------------------------------------------
                                   95/NT CD                    $  0.00              N
- ---------------------------------------------------------------------------------------
                                   Freight                     $  0.00              N
- ---------------------------------------------------------------------------------------
                      541316N      Visual Basic V5.0 Pro       $  0.00              N
- ---------------------------------------------------------------------------------------
                                   Freight                     $  0.00              N
- ---------------------------------------------------------------------------------------
Isec                  97093022     Fume Hood                   $  0.00              N
- ---------------------------------------------------------------------------------------
                                   Fume Hood                   $  0.00              N
- ---------------------------------------------------------------------------------------
                                   Solvent Cabinets            $  0.00              N
- ---------------------------------------------------------------------------------------
                                   Fume Hood Prepping          $  0.00              N
- ---------------------------------------------------------------------------------------
                                                               $  0.00           #N/A
- ---------------------------------------------------------------------------------------
Uniequip              978092       Concentrator Cntrfuge       $  0.00              N
- ---------------------------------------------------------------------------------------
                                   Aspstor Vacuum Pump         $  0.00              N
- ---------------------------------------------------------------------------------------
                                   Freight                     $  0.00              N
- ---------------------------------------------------------------------------------------
MJ Research, inc.     42107        ALD-1233 Dual Alpha         $  0.00              N
- ---------------------------------------------------------------------------------------
                                                               $  0.00           #N/A
- ---------------------------------------------------------------------------------------
                                   Freight                     $  0.00              N
- ---------------------------------------------------------------------------------------
Pfeiffer Vacuum       268868       PKR250 Guage 40KF           $  0.00              N
- ---------------------------------------------------------------------------------------
                                                               $  0.00           #N/A
- ---------------------------------------------------------------------------------------
                                   Freight                     $  0.00              N
- ---------------------------------------------------------------------------------------
Simco Products        0014780-IN   HP 450C Inkjet Printer      $  0.00              N
- ---------------------------------------------------------------------------------------
                                   Roll Feed D                 $  0.00              N
- ---------------------------------------------------------------------------------------
                                   D Size Legs                 $  0.00              N
- ---------------------------------------------------------------------------------------
                                                               $  0.00           #N/A
- ---------------------------------------------------------------------------------------
                            TOTAL AMOUNT DUE TO LESSEE     $ 62,484.74
- ---------------------------------------------------------------------------------------
                                           TOTAL AMOUNT DUE TO VENDOR     $157,509.66
                                                         ------------------------------
                                                           TOTAL DRAW     $219,994.40
                                                         ------------------------------
</TABLE>


Lessee Signature: __________________________   Date:  _____________________


                                  Page 3 of 3
                   Property of Phoenix Leasing Incorporated
<PAGE>

                                      SALE LEASEBACK ADDENDUM
                                      to Schedule No. 01
                                      of MASTER EQUIPMENT LEASE
                                      Dated as of February 5, 1998
                                      Between SEQUENOM, INC.
                                      and PHOENIX LEASING INCORPORATED


This Addendum to Master Equipment Lease is made and entered into as of February
25, 1998 between PHOENIX LEASING INCORPORATED ("Lessor") and SEQUENOM, INC.
("Lessee").

Notwithstanding anything to the contrary contained in the Lease referenced
above, Lessor and Lessee agree as follows:

1.   Lessee shall sell the Equipment to and lease the Equipment from Lessor and
     Lessor shall purchase the Equipment from and lease the Equipment to Lessee
     upon the terms and conditions of the Bill of Sale attached hereto as
     Attachment 1.

2.   Lessee represents and warrants that:

     (a)  Lessee has the right to sell the Equipment as set forth herein,

     (b)  the Equipment and Lessee's right, title and interest in such Equipment
          is, as of the date of the Bill of Sale, free from all claims, liens,
          security interests and encumbrances,

     (c)  Lessee will defend the sale against lawful claims and demands of all
          persons, and

     (d)  the purchase price of the Equipment is equal to the fair market value
          of such Equipment at the time of sale.

   LESSOR:                                  LESSEE:

   PHOENIX LEASING INCORPORATED             SEQUENOM, INC.

   By: /s/ Christy (Illegible)              By: /s/ Stephen Zaniboni

   Name: /s/ Christy (Illegible)            Name: (Print):  Stephen Zaniboni

   Title: Contract Administrator            Title: VP Finance
<PAGE>

                             OFFICER'S CERTIFICATE
                             ---------------------

The undersigned, Stephen Zaniboni, hereby certifies that:

i)   I am the Treasurer/Chief Financial Officer of SEQUENOM, INC., a Delaware
     corporation;

ii)  as such officer, I am familiar with the terms and conditions of that
     certain Master Equipment Lease (the "Lease") dated as of February 5, 1998
     between SEQUENOM, INC. ("Lessee") and PHOENIX LEASING INCORPORATED
     ("Lessor");

iii) this certificate is delivered in connection with the leasing of certain
     equipment under a Schedule with Lessor, the equipment is described in the
     Schedule and the equipment is free and clear from any and all liens,
     charges, security interests or other encumbrances which may affect Lessor's
     right, title or interest in and to the equipment;

iv)  there has been no material adverse change in the financial condition of
     Lessee from the date of its most recent financial statements, true copies
     of which have been delivered to Lessor; and

v)   no event which, with the giving of notice or passage of time, or both,
     could become an Event of Default under the Lease has occurred and is
     continuing.

vi)  Lessee if performing according to Lessee's business plan described in
     Section 3 of the Lease, a true copy of which business plan has been
     delivered to Lessor;

vii) the representations and warranties in Section 5 of the Lease are true and
     correct as of the date hereof.

IN WITNESS WHEREOF, I hereby execute this certificate on this 19 day of
February, 1998.

                                            /s/ Stephen Zaniboni
                                            ---------------------------------
<PAGE>

                                 ATTACHMENT 1
                                 BILL OF SALE


For valuable consideration SEQUENOM, INC. ("Seller") sells to PHOENIX LEASING
INCORPORATED ("Buyer"), the property listed on Exhibit A hereof (the
"Equipment").

Seller covenants and warrants that:

(1)  It is the owner of, and has absolute title to, the Equipment which is free
     and clear of all claims, liens and encumbrances.

(2)  It has not made any prior sale, assignment, or transfer of the Equipment.

(3)  It has the present right, power, and authority to sell the Equipment to
     Buyer.

(4)  All action has been taken which is required to make this Bill of Sale a
     legal, valid and binding obligation of Seller.

Seller shall forever warrant and defend the sale of Equipment to Buyer, its
successors and assigns, against any person claiming an interest in the
Equipment.

This Bill of Sale is binding on the successors and assigns of Seller and inures
to the benefit of the successors and assigns of Buyer.

Executed on 2/12, 1998.


                                           SEQUENOM, INC.


                                           By: /s/ Stephen Zaniboni
                                               ------------------------------

                                           Name (Print): Stephen Zaniboni
                                                         --------------------

                                           Title:        VP Finance
                                                 ----------------------------
<PAGE>

                                   SCHEDULE
                                   --------

                                      Schedule No. 02 to Lease
                                      Dated as of February 5, 1998
                                      Between SEQUENOM, INC.
                                      and PHOENIX LEASING INCORPORATED

A.  Description and Purchase Price of Equipment
    -------------------------------------------

 Description of Equipment
     (quantity, model          Purchase           Mfr./      Street Address
    and serial number)          Price      Rent  Vendor  City, State and County
 ---------------------          -----      ----  ------  ----------------------

See Exhibit A attached hereto.

Total:                       $42,319.65 $1,151.09


B.      Terms
        -----

Base Term:           The Base Term shall commence on the date the Equipment is
                     received, installed and accepted for use, as shown on the
                     Acceptance Notice, and continue for 42 full months after
                     the "Rent Start Date."

Rent Start Date:     This shall be the first day of the month following the
                     month during which the Base Term commences; provided,
                     however, that if the Equipment is accepted on the first day
                     of the month, the Rent Start Date shall commence on the
                     same day that the Base Term commences.

Lease Rate Factor (expressed as a percentage of Equipment's original Purchase
Price): 2.72%

Monthly Rental Payments in advance.

Base Rent Due:       Payable on the Rent Start Date shall be (1) the first and
                     last Rental Amount including any sales or use tax and (2)
                     an amount equal to 1/30th of the monthly rental amount
                     using a rate of 2.72% multiplied by the number of days, if
                     any, between (and including) the date the Base Term
                     commences and (but not including) the Rent Start Date,
                     except that, if the date of the Acceptance Notice related
                     to this Schedule is dated on or after the 20th of the
                     month, this amount shall not be included in the Base Rent
                     Due.

C.  Invoice Information:  Lessee's and Lessor's addresses for invoice purposes
    -------------------
for the Equipment on the Schedule shall be as follows:

Lessee's Invoice Address:                  Remit Monthly Rental Amount To:
- ------------------------                   ------------------------------
SEQUENOM, INC.                             PHOENIX LEASING INCORPORATED
11555Sorrento Valley Road                  P.O. Box 200432
San Diego, CA 92121                        Dallas, TX 75320-0432

Attention:  Mr. Steve Zaniboni, Vice President, Finance and Administration

                                       1
<PAGE>

                              Schedule No. 02 to Lease
                              Dated as of February 5, 1998
                              Between SEQUENOM, INC.
                              and PHOENIX LEASING INCORPORATED

D.  Casualty Values:  See attachment hereto.
    ---------------

E.  Special Provisions:  1. Lessor's payment for Equipment hereunder is
    ------------------
conditioned on Lessor's satisfaction of the conditions set forth in Section 3 of
the Lease and 2. Sale Leaseback Addendum.

F.  End of Lease Position:  (a) General. Lessee shall be required to choose a
    ---------------------       -------
final purchase or extension requirement ("End of Lease Position") at the
expiration of the Base Term (as defined in the Schedule) of the first Schedule
to the Lease. That choice shall be an election of Lessee's End of Lease Position
for all, but not less than all, of the Equipment under all Schedules to the
Lease. Lessee shall provide written notice of its election to Lessor at least 90
days prior to the end of the Base Term of the first Schedule.

Any Equipment purchase election shall be a purchase of the Equipment, AS-IS,
WHERE-IS. Upon Lessor's receipt of the purchase price, Lessor shall issue to
Lessee an equipment bill of sale, transferring title to the Equipment to the
Lessee without any representation or warranty whatsoever. Lessee shall be
responsible for all applicable taxes in connection with any Equipment purchase.

In the event Lessee does not provide at least 90 days' prior written notice of
its election, Lessee shall be deemed to have elected Election No. 2.

At the expiration of the Base Term of the first Schedule Lessee shall be
required to elect to either:

Election No. 1:  Purchase the Equipment for 25% of the Equipment's original
- --------------
purchase price; or

Election No. 2:  Extend the Schedule's Base Term for an additional 12 months
- --------------
("Extended Term") for a monthly rate of 2.50% of the Equipment's original
purchase price.

At the expiration of the Extended Term, Lessee shall purchase the Equipment for
$1.00.

LESSOR AND LESSEE AGREE THAT THIS SCHEDULE SHALL CONSTITUTE A LEASE OF THE
EQUIPMENT DESCRIBED ABOVE, SUBJECT TO THE TERMS AND CONDITIONS OF THIS SCHEDULE
AND OF THE MASTER EQUIPMENT LEASE DATED FEBRUARY 5, 1998 BETWEEN LESSEE AND
LESSOR. THE TERMS AND CONDITIONS OF SUCH MASTER EQUIPMENT LEASE ARE HEREBY
INCORPORATED BY REFERENCE AND MADE A PART HEREOF TO THE SAME EXTENT AS IF SUCH
TERMS AND CONDITIONS WERE SET FORTH IN FULL HEREIN.

LESSOR:                                   LESSEE:

PHOENIX LEASING INCORPORATED              SEQUENOM, INC.


By: /s/ Andrew Ferguson                   By: /s/ Steve Zaniboni
    ----------------------------              -----------------------------
Name: Andrew Ferguson                     Name (Print): Steve Zaniboni
      --------------------------               ----------------------------
Title: Illegible                          Title: VP Finance
       -------------------------                 --------------------------
Date: 3-20-98                             Date: 3-12-99
      --------------------------                ---------------------------

                                       2
<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A

<TABLE>
<CAPTION>
     Lessee:  SEQUENOM, INC.
              --------------------

Master Contract:   0135                                                            Schedule:   02
                  -------                                                                    -----
- ----------------------------------------------------------------------------------------------------------------------------------
Vendor Name                                                                                           L            Invoiced
(abbreviation         Invoice           Brief Description                   Eqp        Serial         O           Amt Net of
OK)                   No.               of Item                             Code       Number         C           Sales Tax
- ----------------------------------------------------------------------------------------------------------------------------------
<S>                   <C>               <C>                                 <C>        <C>            <C>         <C>
Akcron                1663080           Micron Computer ATO                 1                                        2,969.00
- ----------------------------------------------------------------------------------------------------------------------------------
                                        Freight                             27                                          99.00
- ----------------------------------------------------------------------------------------------------------------------------------
                                        MMP Speakers                        1                                          230.10
- ----------------------------------------------------------------------------------------------------------------------------------
NECX                  576898            Windows NT V4.0                     24                                         274.95
- ----------------------------------------------------------------------------------------------------------------------------------
                                        Freight                             27                                           5.95
- ----------------------------------------------------------------------------------------------------------------------------------
                      576547            32 mb kit for Deli Lar.             1                                          107.95
- ----------------------------------------------------------------------------------------------------------------------------------
                                        Freight                             27                                           3.95
- ----------------------------------------------------------------------------------------------------------------------------------
                      581342            Windows 95 intrnt explr             24                                         176.95
- ----------------------------------------------------------------------------------------------------------------------------------
                                        freight                             27                                           5.95
- ----------------------------------------------------------------------------------------------------------------------------------
                      573464            Laseerjet 5Sinx 600 dpi             1                                        2,629.95
- ----------------------------------------------------------------------------------------------------------------------------------
                                        Freight                             27                                          69.90
- ----------------------------------------------------------------------------------------------------------------------------------
        Business      24994A            Toshiba 2860 Copier                 5                                        8,490.00
- ----------------------------------------------------------------------------------------------------------------------------------
                                        Copy Board                          5                                        3,800.00
- ----------------------------------------------------------------------------------------------------------------------------------
 Fisher Scientific    805749            hematolgy Chem.                     2                                          395.27
- ----------------------------------------------------------------------------------------------------------------------------------
                                        Freight                             27                                           4.36
- ----------------------------------------------------------------------------------------------------------------------------------
                      499288            pipette series 2100                 2                                          171.24
- ----------------------------------------------------------------------------------------------------------------------------------
                      716854            pipette sis 2100                    2                                          171.24
- ----------------------------------------------------------------------------------------------------------------------------------
                                        pipette series 2100 2-              2          quantity of 3                   513.72
- ----------------------------------------------------------------------------------------------------------------------------------
                                        Locator 8w/lvl monitor              2                                        2,455.39
- ----------------------------------------------------------------------------------------------------------------------------------
                      761614            Inverted Microscope                 2                                        3,142.86
- ----------------------------------------------------------------------------------------------------------------------------------
                                        pipette series 2100 0.1             2                                          741.56
- ----------------------------------------------------------------------------------------------------------------------------------
                      626713            purif-4cl II w/uv li/sfx            2                                        5,882.02
- ----------------------------------------------------------------------------------------------------------------------------------
                                        delivery                            27                                          80.00
- ----------------------------------------------------------------------------------------------------------------------------------
                      649937            incubator co2 single ir             2                                        3,896.63
- ----------------------------------------------------------------------------------------------------------------------------------
                                             display for                    2                                          396.00
- ----------------------------------------------------------------------------------------------------------------------------------
                                        Freight                             27                                         120.00
- ----------------------------------------------------------------------------------------------------------------------------------
                      604650            Eppendorf cent. md.                 2                                        5,485.71

<CAPTION>
     Lessee:  SEQUENOM, INC.
              --------------------

Master Contract:   0135                                               Schedule:   02
                  -------                                                       -----
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                                              No entry required
Vendor Name           Invoice         Amt Paid by      Tax Pd                             ----------------------------------------
(abbreviation         No.               Lesseee       Vendor?     Check    Transac     Net $ Amt       Net $ Amt.
OK)                                                    (Y/N)       No.      (Date     Due Lessee      Due Vendor
- ----------------------------------------------------------------------------------------------------------------------------------
<S>                   <C>             <C>             <C>         <C>      <C>        <C>             <C>
Akcron                1663080                                                              $0.00        $ 2,969.00      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                                           $0.00        $    99.00      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                                           $0.00        $   230.10      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
NECX                  576898                                                               $0.00        $   274.95      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                                           $0.00        $     5.95      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                      576547                                                               $0.00        $   107.95      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                                           $0.00        $     3.95      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                      581342                                                               $0.00        $   176.95      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                                           $0.00        $     5.95      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                      573464                                                               $0.00        $ 2,629.95      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                                           $0.00        $    69.90      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
        Business      24994A                                                               $0.00        $ 8,490.00      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                                           $0.00        $ 3,800.00      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
Fisher Scientific     805749                                                               $0.00        $   395.27      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                                           $0.00        $     4.36      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                      499288                                                               $0.00        $   171.24      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                      716854                                                               $0.00        $   171.24      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                                           $0.00        $   513.72      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                                           $0.00        $ 2,455.39      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                      761614                                                               $0.00        $ 3,142.86      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                                           $0.00        $   741.56      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                      626713                                                               $0.00        $ 5,882.02      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                                           $0.00        $    80.00      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                      649937                                                               $0.00        $ 3,896.63      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                                           $0.00        $   396.00      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                                           $0.00        $   120.00      #N/A
- ----------------------------------------------------------------------------------------------------------------------------------
                      604650                                                               $0.00        $ 5,485.71      #N/A
                                                                                    ----------------------------------------------
                                                         TOTAL AMOUNT DUE TO LESSEE        $0.00
                                                                                    ----------------------------------------------
                                                                      TOTAL AMOUNT DUE TO VENDOR        $42,319.65
                                                                                                    ------------------------------
                                                                                      TOTAL DRAW        $42,319.65
                                                                                                    ------------------------------
</TABLE>

Lessee Signature:   /s/ Stephen Zaniboni             Date:   3/16/99
                    ---------------------                  -----------


                          Page 1 of __

<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A

 Lessee: SEQUENOM, INC.
         ----------------------
         11555 SORRENTO VALLEY ROAD
         SAN DIEGO, CA 94121

<TABLE>
<CAPTION>
Master Contract:  0135                                                                                         Schedule:    01
                 ------                                                                                                   -------
- ---------------------------------------------------------------------------------------------------------------------------------
                                                                                      Invoiced Amt               Tax Pd
 Vendor Name          Invoice      Brief Description       Eqp    Serial                    Net of   Amt Paid    Vendor    Check
 (abbreviation OK)    No.          of Item                 Code   Number       LOC       Sales Tax   by Lessee    (Y/N)     No.
- ---------------------------------------------------------------------------------------------------------------------------------
<S>                   <C>          <C>                     <C>    <C>          <C>    <C>            <C>         <C>       <C>
- ----------------------------------------------------------------------------------------------------------------------------------
 Beckman Instrmts     331062FT01   Pipettor Ensemble          2   304017APS     1        46,360.50                  N
- ---------------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------------
                                   Freight & Insurance       27                 1           696.16                  N
- ---------------------------------------------------------------------------------------------------------------------------------
                      331062FT02   Dsposble Tip Wash Sys.     2   90006         1         5,580.00                  N
- ---------------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------------
                                   Freight & Insurance       27                 1           142.68                  N
- ---------------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------------
 MJ Research, inc.         43466   PTC-0225 Tetrad Chssis    26   TD002536      2        14,245.25                  N
- ---------------------------------------------------------------------------------------------------------------------------------
                                   ALP-1296 Alpha/Power      26   AL013185/     2         3,955.50                  N
- ---------------------------------------------------------------------------------------------------------------------------------
                                   Bonnet 200/225            26   PB0361        2                                   N
- ---------------------------------------------------------------------------------------------------------------------------------
                                   ALP-1296 Alpha/Power      26   AL014028/     2         3,955.50                  N
- ---------------------------------------------------------------------------------------------------------------------------------
                                   Bonnet 200/225            26   PB0354        2                                   N
- ---------------------------------------------------------------------------------------------------------------------------------
                                   ALP-1296 Alpha/Power      26   AL014037/     2         3,955.50                  N
- ---------------------------------------------------------------------------------------------------------------------------------
                                   Bonnet 200/225            26   PB0371        2                                   N
- ---------------------------------------------------------------------------------------------------------------------------------
                                   ALP-1296 Alpha/Power      26   AL014041/     2         3,955.50                  N
- ---------------------------------------------------------------------------------------------------------------------------------
                                   Bonnet 200/225            26   PB0340        2                                   N
- ---------------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------------
                                   Freight                   27                 2           105.00                  N
- ---------------------------------------------------------------------------------------------------------------------------------
                           43377   FTC-0225 Tetrad Chssis     2   TD002426      1        14,245.25                  N
- ---------------------------------------------------------------------------------------------------------------------------------
                                   ALP-1296 Alpha/Power       2   AL014021/     1         3,955.50                  N
- ---------------------------------------------------------------------------------------------------------------------------------
                                   Bonnet 200/225             2   PB0369        1                                   N
- ---------------------------------------------------------------------------------------------------------------------------------
                                   ALP-1296 Alpha/Power       2   AL014023/     1         3,955.50                  N
- ---------------------------------------------------------------------------------------------------------------------------------
                                   Bonnet 200/225             2   PB0370        1                                   N
- ---------------------------------------------------------------------------------------------------------------------------------
                                   ALP-1296 Alpha/Power       2   AL014025/     1         3,955.50                  N
- ---------------------------------------------------------------------------------------------------------------------------------
                                   Bonnet 200/225             2   PB0359        1                                   N
- ---------------------------------------------------------------------------------------------------------------------------------
                                   ALP-1296 Alpha/Power       2   AL014030/     1         3,955.50                  N
- ---------------------------------------------------------------------------------------------------------------------------------
                                   Bonnet 200/225             2   PB0358        1                                   N
- ---------------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------------
                                   Freight                   27                 1           122.00                  N
- ---------------------------------------------------------------------------------------------------------------------------------
 PE Biosystems          90056171   DNA SYN 4 COL/8BASE        2   394-          1        37,000.00                  N
- ---------------------------------------------------------------------------------------------------------------------------------
                                   & Kit                      2   100000004J    1                                   N
- ---------------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------------
                                   Freight                   27                 1           286.38                  N
- ---------------------------------------------------------------------------------------------------------------------------------
 Micron                  1534719   Cmptr ATO Model BOM        1   1088241-0001  1         2,597.00                  N
- ---------------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------------
                                   Freight                   27                 1            99.00                  N
- ---------------------------------------------------------------------------------------------------------------------------------
 Necx                    560093N   Visual C++ V5.0 Pro       24   59819-811-    1           429.95                  N
- ---------------------------------------------------------------------------------------------------------------------------------
                                   95/NT CD                   2   2088451-      1                                   N
- ---------------------------------------------------------------------------------------------------------------------------------

<CAPTION>
- -------------------------------------------------------------------------------------
                                                       No entry required
                                                    ---------------------------------
 Vendor Name          Invoice         Transact       Net $ Amt    Net $ Amt.
 (abbreviation OK)    No.                Date       Due Lessee    Due Vendor
- -------------------------------------------------------------------------------------
<S>                   <C>             <C>           <C>           <C>           <C>
 Beckman Instrmts     331062FT01                         $0.00    $46,360.50       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $     0.00    #N/A
- -------------------------------------------------------------------------------------
                                                         $0.00    $   696.16       N
- -------------------------------------------------------------------------------------
                      331062FT02                         $0.00    $ 5,580.00       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $     0.00    #N/A
- -------------------------------------------------------------------------------------
                                                         $0.00    $   142.68       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $     0.00    #N/A
- -------------------------------------------------------------------------------------
 MJ Research, inc.         43466                         $0.00    $14,245.25       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $ 3,955.50       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $     0.00       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $ 3,955.50       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $     0.00       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $ 3,955.50       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $     0.00       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $ 3,955.50       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $     0.00       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $     0.00    #N/A
- -------------------------------------------------------------------------------------
                                                         $0.00    $   105.00       N
- -------------------------------------------------------------------------------------
                           43377                         $0.00    $14,245.25       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $ 3,955.50       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $     0.00       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $ 3,955.50       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $     0.00       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $ 3,955.50       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $     0.00       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $ 3,955.50       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $     0.00       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $     0.00    #N/A
- -------------------------------------------------------------------------------------
                                                         $0.00    $   122.00       N
- -------------------------------------------------------------------------------------
 PE Biosystems          90056171                         $0.00    $37,000.00       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $     0.00       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $     0.00    #N/A
- -------------------------------------------------------------------------------------
                                                         $0.00    $   286.38       N
- -------------------------------------------------------------------------------------
 Micron                  1534719                         $0.00    $ 2,597.00       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $     0.00    #N/A
- -------------------------------------------------------------------------------------
                                                         $0.00    $    99.00       N
- -------------------------------------------------------------------------------------
 Necx                    560093N                         $0.00    $   429.95       N
- -------------------------------------------------------------------------------------
                                                         $0.00    $     0.00       N
- -------------------------------------------------------------------------------------
</TABLE>
<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A

<TABLE>
<S>              <C>         <C>                        <C>    <C>              <C>        <C>            <C>         <C>   <C>
- ---------------------------------------------------------------------------------------------------------------------------------
                                                         2     85206            1                                     N
- ---------------------------------------------------------------------------------------------------------------------------------
                             Freight                    27                      1              3.95                   N
- ---------------------------------------------------------------------------------------------------------------------------------
                 564237N     Deskjet 890CXI PC 600       1     US77Q120DX       1            424.95                   N
- ---------------------------------------------------------------------------------------------------------------------------------
                             Freight                    27                      1             12.91                   N
- ---------------------------------------------------------------------------------------------------------------------------------
 Micron          1591926     Cmptr Laptop System         1     1110980-0001     1          3,467.00                   N
- ---------------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------------
                             Freight                    27                      1             47.68                   N
- ---------------------------------------------------------------------------------------------------------------------------------
                 1416281     Cmptr ATO Model BOM         1     1032255/0001     1          3,647.00       3,647.00    Y     2105
- ---------------------------------------------------------------------------------------------------------------------------------
                             Cmptr ATO Model BOM         1     1033255/0002     1          3,647.00       3,647.00    Y     2105
- ---------------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------------
                             Freight                    27                      1            258.00         258.00    Y     2105
- ---------------------------------------------------------------------------------------------------------------------------------
 Necx             517431     LifeBook 735dx 133          1                      1          1,879.95       1,879.95    N     2128
- ---------------------------------------------------------------------------------------------------------------------------------
                             Freight                    27                      1             15.75          15.75    N     2128
- ---------------------------------------------------------------------------------------------------------------------------------
 Micron          1477538     Cmptr ATO Model BOM         1     1058058-0001     1          2,067.00       2,067.00    Y     2157
- ---------------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------------
                             Freight                    27                      1            119.00         119.00    Y     2157
- ---------------------------------------------------------------------------------------------------------------------------------
                 1513020    Cmptr ATO Model BOM          1     1076930-0001     1          3,547.00       3,547.00    Y     2216
- ---------------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------------
                            Freight                     27                      1            119.00         119.00    Y     2216
- ---------------------------------------------------------------------------------------------------------------------------------
                 1513022    Cmptr ATO Model BOM          1     1076996-0001     1          3,836.00       3,836.00    Y     2216
- ---------------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------------
                             Freight                    27                      1              0.00           0.00    Y     2216
- ---------------------------------------------------------------------------------------------------------------------------------
                 1515296     Cmptr ATO Model BOM         1     1076945-0001     1          2,438.00       2,438.00    Y     2216
- ---------------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------------
                             Freight                    27                      1             99.00          99.00    Y     2216
- ---------------------------------------------------------------------------------------------------------------------------------
 Necx             540370     LifePro 720 LCD Prjctor    17     4G7483316        1          5,699.95       5,699.95    N     2229
- ---------------------------------------------------------------------------------------------------------------------------------
                             Freight                    27                      1             14.95          14.95    N     2229
- ---------------------------------------------------------------------------------------------------------------------------------
 Oracle           918340     Oracle for Window NT       24     A54496-01        1          1,327.50       1,327.50    Y     2069
- ---------------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------------
 Biorad            75441     Chem Window                24     UEW1019188       1            599.00         599.00    Y     2044
- ---------------------------------------------------------------------------------------------------------------------------------
                             Chem Windown               24     UEW1019175       1            999.00         999.00    Y     2044
- ---------------------------------------------------------------------------------------------------------------------------------
                                                        24     SUITES           1                                     Y     2044
- ---------------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------------
                             Freight                    27                      1             10.00          10.00    Y     2044
- ---------------------------------------------------------------------------------------------------------------------------------
 Necx            520474N     Credit Card Ether Adpt.    24     ?                1            127.95         127.95    N     2148
- ---------------------------------------------------------------------------------------------------------------------------------
                 522742N     Visual C++ V5.0 Pro        24     59819-809-       1            429.95         429.95    N     2158
- ---------------------------------------------------------------------------------------------------------------------------------
                             95/NT CD                   24     2464685-         1                                     N     2158
- ---------------------------------------------------------------------------------------------------------------------------------
                             Freight                    27                      1              3.95           3.95    N     2158
- ---------------------------------------------------------------------------------------------------------------------------------
                 541316N     Visual Basic V5.0 Pro      24     203-056-016      1            429.95         429.95    N     2242
- ---------------------------------------------------------------------------------------------------------------------------------
                             Freight                    27                      1              5.95           5.95    N     2242
- ---------------------------------------------------------------------------------------------------------------------------------
 Isec           97093022     Fume Hood                   2     016070690        1          8,100.00       8,100.00    Y     VAR
- ---------------------------------------------------------------------------------------------------------------------------------
                             Fume Hood                   2     016070691        1          8,100.00       8,100.00    Y     VAR
- ---------------------------------------------------------------------------------------------------------------------------------
                             Solvent Cabinets            2                      1          2,148.00       2,148.00    Y     VAR
- ---------------------------------------------------------------------------------------------------------------------------------
                             FumeHood Prepiping          2                      1            700.00         700.00    Y     VAR
- ---------------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------------
 Uniequip         976092     Concentrator Cntrfuge       2     976034714        1          3,140.00       3,140.00    N     Wire
- ---------------------------------------------------------------------------------------------------------------------------------
                             Asprtor Vacuum Pump         2     976034838        1          3,370.00       3,370.00    N     Wire
- ---------------------------------------------------------------------------------------------------------------------------------
                             Freight                    27                      1            308.74         308.74    N     Wire
- ---------------------------------------------------------------------------------------------------------------------------------

<CAPTION>
<S>             <C>                <C>              <C>           <C>           <C>
- -------------------------------------------------------------------------------------
                                                    $    0.00     $     0.00       N
- -------------------------------------------------------------------------------------
                                                    $    0.00     $     3.95       N
- -------------------------------------------------------------------------------------
                 564237N                            $    0.00     $   424.95       N
- -------------------------------------------------------------------------------------
                                                    $    0.00     $    12.91       N
- -------------------------------------------------------------------------------------
 Micron          1591926                            $    0.00     $ 3,467.00       N
- -------------------------------------------------------------------------------------
                                                    $    0.00     $     0.00    #N/A
- -------------------------------------------------------------------------------------
                                                    $    0.00     $    47.68       N
- -------------------------------------------------------------------------------------
                 1416281           11/25/97         $3,647.00     $     0.00       N
- -------------------------------------------------------------------------------------
                                   11/25/97         $3,647.00     $     0.00       N
- -------------------------------------------------------------------------------------
                                                    $    0.00     $     0.00    #N/A
- -------------------------------------------------------------------------------------
                                   11/25/97         $  258.00     $     0.00       N
- -------------------------------------------------------------------------------------
 Necx             517431           11/30/97         $1,879.95     $     0.00       N
- -------------------------------------------------------------------------------------
                                   11/30/97         $   15.75     $     0.00       N
- -------------------------------------------------------------------------------------
 Micron          1477538           12/20/97         $2,067.00     $     0.00       N
- -------------------------------------------------------------------------------------
                                                    $    0.00     $     0.00    #N/A
- -------------------------------------------------------------------------------------
                                    12/20/97        $  119.00     $     0.00       N
- -------------------------------------------------------------------------------------
                 1513020            12/29/97        $3,547.00     $     0.00       N
- -------------------------------------------------------------------------------------
                                                    $    0.00     $     0.00    #N/A
- -------------------------------------------------------------------------------------
                                    12/29/97        $  119.00     $     0.00       N
- -------------------------------------------------------------------------------------
                 1513022            12/29/97        $3,836.00     $     0.00       N
- -------------------------------------------------------------------------------------
                                                    $    0.00     $     0.00    #N/A
- -------------------------------------------------------------------------------------
                                   12/29/97         $    0.00     $     0.00       N
- -------------------------------------------------------------------------------------
                 1515296           12/29/97         $2,438.00     $     0.00       N
- -------------------------------------------------------------------------------------
                                                    $    0.00     $     0.00    #N/A
- -------------------------------------------------------------------------------------
                                   12/29/97         $   99.00     $     0.00       N
- -------------------------------------------------------------------------------------
 Necx             540370           12/30/97         $5,699.95     $     0.00       N
- -------------------------------------------------------------------------------------
                                   12/30/97         $   14.95     $     0.00       N
- -------------------------------------------------------------------------------------
 Oracle           918340           11/13/97         $1,327.50     $     0.00       N
- -------------------------------------------------------------------------------------
                                                    $    0.00     $     0.00    #N/A
- -------------------------------------------------------------------------------------
 Biorad            75441           11/10/97         $  599.00     $     0.00       N
- -------------------------------------------------------------------------------------
                                   11/10/97         $  999.00     $     0.00       N
- -------------------------------------------------------------------------------------
                                   11/10/97         $    0.00     $     0.00       N
- -------------------------------------------------------------------------------------
                                                    $    0.00     $     0.00    #N/A
- -------------------------------------------------------------------------------------
                                   11/10/97         $   10.00     $     0.00       N
- -------------------------------------------------------------------------------------
 Necx            520474N            12/5/97         $  127.95     $     0.00       N
- -------------------------------------------------------------------------------------
                 522742N           12/10/97         $  429.95     $     0.00       N
- -------------------------------------------------------------------------------------
                                   12/10/97         $    0.00     $     0.00       N
- -------------------------------------------------------------------------------------
                                   12/10/97         $    3.95     $     0.00       N
- -------------------------------------------------------------------------------------
                 541316N           12/31/97         $  429.95     $     0.00       N
- -------------------------------------------------------------------------------------
                                   12/31/97         $    5.95     $     0.00       N
- -------------------------------------------------------------------------------------
 Isec           97093022             1/8/98         $8,100.00     $     0.00       N
- -------------------------------------------------------------------------------------
                                     1/8/98         $8,100.00     $     0.00       N
- -------------------------------------------------------------------------------------
                                     1/8/98         $2,148.00     $     0.00       N
- -------------------------------------------------------------------------------------
                                     1/8/98         $  700.00     $     0.00       N
- -------------------------------------------------------------------------------------
                                                    $    0.00     $     0.00    #N/A
- -------------------------------------------------------------------------------------
 Uniequip         976092           10/20/97         $3,140.00     $     0.00       N
- -------------------------------------------------------------------------------------
                                   10/20/97         $3,370.00     $     0.00       N
- -------------------------------------------------------------------------------------
                                   10/20/97         $  308.74     $     0.00       N
- -------------------------------------------------------------------------------------
</TABLE>
<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A

<TABLE>
- --------------------------------------------------------------------------------------------------------------------------
<S>                  <C>            <C>                        <C>   <C>             <C>      <C>           <C>        <C>
MJ Research, inc.          42107    ALD-1233 Dual Alpha         2    AL012491         1       2,370.25      2,370.25    Y
- --------------------------------------------------------------------------------------------------------------------------

- --------------------------------------------------------------------------------------------------------------------------
                                    Freight                    27                     1          16.00         16.00    Y
- --------------------------------------------------------------------------------------------------------------------------
Pfeiffer Vacuum           268868    PKR250 Guage 40KF           2    2416V015         1         653.90        653.90    Y
- --------------------------------------------------------------------------------------------------------------------------

- --------------------------------------------------------------------------------------------------------------------------
                                    Freight                    27                     1          12.00         12.00    Y
- --------------------------------------------------------------------------------------------------------------------------
Simco Products        0014780-IN    HP 450C Inkjet Printer      1    ESA7905454       1       1,795.00      1,795.00    Y
- --------------------------------------------------------------------------------------------------------------------------
                                    Roll Feed D                 1                     1         225.00        225.00    Y
- --------------------------------------------------------------------------------------------------------------------------
                                    D Size Legs                 1                     1         225.00        225.00    Y
- --------------------------------------------------------------------------------------------------------------------------

- --------------------------------------------------------------------------------------------------------------------------
</TABLE>

<TABLE>
- ---------------------------------------------------------------------------------------------------------
<S>                   <C>                  <C>        <C>             <C>             <C>             <C>
MJ Research, inc.          42107           2106       11/25/97         $  2,370.25     $      0.00        N
- ------------------------------------------------------------------------------------------------------------
                                                                       $      0.00     $      0.00     #N/A
- ------------------------------------------------------------------------------------------------------------
                                           2106       11/25/97         $     16.00     $      0.00        N
- ------------------------------------------------------------------------------------------------------------
Pfeiffer Vacuum           268868           2219       12/29/97         $    653.90     $      0.00        N
- ------------------------------------------------------------------------------------------------------------
                                                                       $      0.00     $      0.00     #N/A
- ------------------------------------------------------------------------------------------------------------
                                           2219       12/29/97         $     12.00     $      0.00        N
- ------------------------------------------------------------------------------------------------------------
Simco Products        0014780-IN           2234       12/30/97         $  1,795.00     $      0.00        N
- ------------------------------------------------------------------------------------------------------------
                                           2234       12/30/97         $    225.00     $      0.00        N
- ------------------------------------------------------------------------------------------------------------
                                           2234       12/30/97         $    225.00     $      0.00        N
- ------------------------------------------------------------------------------------------------------------
                                                                       $      0.00     $      0.00     #N/A
- ------------------------------------------------------------------------------------------------------------
                                         TOTAL AMOUNT DUE TO LESSEE    $ 62,484.74
                                                                     ------------------------------------
                                                       TOTAL AMOUNT DUE TO VENDOR      $259,250.16
                                                                                       ------------------
                                                                      TOTAL DRAW       $321,734.90
                                                                                       ------------------
</TABLE>

Lessee Signature:_____________________________  Date:______
<PAGE>

                                   SCHEDULE
                                   --------

                                          Schedule No. 03 to Lease
                                          Dated as of February 5, 1998
                                          Between SEQUENOM INC.
                                          and PHOENIX LEASING INCORPORATED

A.   Description and Purchase Price of Equipment
     -------------------------------------------

<TABLE>
<CAPTION>
          Description of
             Equipment
         (quantity, model                 Purchase                             Mfr./              Street Address
        and serial number)                 Price              Rent            Vendor          City, State and County
        ------------------                ------              ----            ------          ----------------------
        <S>                               <C>                 <C>             <C>             <C>

     See Exhibit A attached hereto

Total:                                    $200,400.92         $5,451.99
</TABLE>

B.   Terms

Base Term:          The Base Term shall commence on the date the Equipment is
                    received, installed and accepted for use, as shown on the
                    Acceptance Notice, and continue for 42 full months after the
                    "Rent Start Date."

Rent Start Date:    This shall be the first day of the month following the month
                    during which the Base Term commences; provided, however,
                    that if the Equipment is accepted on the first day of the
                    month, the Rent Start Date shall commence on the same day
                    that the Base Term commences.

Lease Rate Factor   (expressed as a percentage of Equipment's original Purchase
                    Price): 2.72%

Monthly Rental Payments in advance.

Base Rent Due:      Payable on the Rent Start Date shall be (1) the first and
                    last Rental Amount including any sales or use tax and (2) an
                    amount equal to 1/30th of the monthly rental amount using a
                    rate of 2.72% multiplied by the number of days, if any,
                    between (and including) the date the Base Term commences and
                    (but not including) the Rent Start Date, except that, if the
                    date of the Acceptance Notice related to this Schedule is
                    dated on or after the 20th of the month, this amount shall
                    not be included in the Base Rent Due.

C.   Invoice Information:  Lessee's and Lessor's addresses for invoice purposes
     -------------------
for the Equipment on the Schedule shall be as follows:

Lessee's Invoice Address:                   Remit Monthly Rental Amount To:
- ------------------------                    ------------------------------
SEQUENOM, INC,                                    PHOENIX LEASING INCORPORATED
11555 Sorento Valley Road                         P. O. Box 200432
San Diego, CA 92121                               Dallas, TX  75320-0432
Attention:   Mr. Steve Zaniboni, Vice President, Finance and Administration

                                       1
<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A

<TABLE>
- ------------------------------------------------------------------------------------------------
<S>              <C>      <C>                    <C>  <C>       <C>  <C>        <C>    <C>  <C>
Insulator Seal     63345  SPCL Power HI Volt      2   0917001   1      615.00   0.00   N    N/A
- ------------------------------------------------------------------------------------------------
                          Freight                27                     11.00   0.00   N    N/A
- ------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------
Necx              618248  Ehterlink              24             1      165.95   0.00   N    N/A
- ------------------------------------------------------------------------------------------------
                          Freight                27                      3.95   0.00   N    N/A
- ------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------
Necx              618434  Vista Tech             24             1      285.95   0.00   N    N/A
- ------------------------------------------------------------------------------------------------
                          Freight                27                      4.70   0.00   N    N/A
- ------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------
Necx              607647  Caviar Eide Ultra DMA  24             1      196.95   0.00   N    N/A
- ------------------------------------------------------------------------------------------------
                          Freight                27             1        6.95   0.00   N    N/A
- ------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------
NECX              619237  Jetdirect ex plus      24             1      219.95   0.00   N    N/A
- ------------------------------------------------------------------------------------------------
                          Freight                27             1       11.81   0.00   N    N/A
- ------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------
Fisher           1527412  Oven Mode 29 120V       2             1    2,279.62   0.00   N    N/A
- ------------------------------------------------------------------------------------------------
                          Freight                27                    129.48   0.00   N    N/A
- ------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------
Necx              618592  ABC Flowcharter        24             1      255.95   0.00   N    N/A
- ------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------
AutoGen             1087  NA1000 for blood        2             1   18,000.00   0.00   N    N/A
- ------------------------------------------------------------------------------------------------
                          Freight                27             1      964.71   0.00   N    N/A
- ------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------
Necx              623274  Superstack II Switch   24             1      654.95   0.00   N    N/A
- ------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------
Fisher           1043019  Protector PCR           2                  2,152.94   0.00   N    N/A
- ------------------------------------------------------------------------------------------------

- -----------------------------------------------------------------------------------------------------
<S>               <C>     <C>                     <C>                <C>          <C>            <C>
Insulator Seal     63345  SPCL Power HI Volt      03/24/98           $     0.00   $     615.00   N
- -----------------------------------------------------------------------------------------------------
                          Freight                                    $     0.00   $      11.00   *N/A
- -----------------------------------------------------------------------------------------------------
                                                                     $     0.00   $       0.00   *N/A
- -----------------------------------------------------------------------------------------------------
Necx              618248  Ehterlink               03/26/98           $     0.00   $     165.95   N
- -----------------------------------------------------------------------------------------------------
                          Freight                                    $     0.00   $       3.95   *N/A
- -----------------------------------------------------------------------------------------------------
                                                                     $     0.00   $       0.00   *N/A
- -----------------------------------------------------------------------------------------------------
Necx              618434  Vista Tech              03/26/98           $     0.00   $     285.95   N
- -----------------------------------------------------------------------------------------------------
                          Freight                                    $     0.00   $       4.70   *N/A
- -----------------------------------------------------------------------------------------------------
                                                                     $     0.00   $       0.00   *N/A
- -----------------------------------------------------------------------------------------------------
Necx              607647  Caviar Eide Ultra DMA   03/11/98           $     0.00   $     196.95   N
- -----------------------------------------------------------------------------------------------------
                          Freight                                    $     0.00   $       6.95   N
- -----------------------------------------------------------------------------------------------------
                                                                     $     0.00   $       0.00   *N/A
- -----------------------------------------------------------------------------------------------------
NECX              619237  Jetdirect ex plus       03/27/98           $     0.00   $     219.95   N
- -----------------------------------------------------------------------------------------------------
                          Freight                                    $     0.00   $      11.81   N
- -----------------------------------------------------------------------------------------------------
                                                                     $     0.00   $       0.00   *N/A
- -----------------------------------------------------------------------------------------------------
Fisher           1527412  Oven Mode 29 120V       03/25/98           $     0.00   $   2,279.62   N
- -----------------------------------------------------------------------------------------------------
                          Freight                                    $     0.00   $     129.48   *N/A
- -----------------------------------------------------------------------------------------------------
                                                                     $     0.00   $       0.00   *N/A
- -----------------------------------------------------------------------------------------------------
Necx              618592  ABC Flowcharter         03/26/98           $     0.00   $     255.95   N
- -----------------------------------------------------------------------------------------------------
                                                                     $     0.00   $       0.00   *N/A
- -----------------------------------------------------------------------------------------------------
AutoGen             1087  NA1000 for blood        03/24/98           $     0.00   $  18,000.00   N
- -----------------------------------------------------------------------------------------------------
                          Freight                                    $     0.00   $     964.71   N
- -----------------------------------------------------------------------------------------------------
                                                                     $     0.00   $       0.00   *N/A
- -----------------------------------------------------------------------------------------------------
Necx              623274  Superstack II Switch    02/20/98           $     0.00   $     654.95   N
- -----------------------------------------------------------------------------------------------------
                                                                     $     0.00   $       0.00   N/A
- -----------------------------------------------------------------------------------------------------
Fisher           1043019  Protector PCR           02/13/98           $     0.00   $   2,152.94   N
- -----------------------------------------------------------------------------------------------------
                            TOTAL AMOUNT DUE TO LESSEE               $32,423.25
- -----------------------------------------------------------------------------------------------------
                                                  TOTAL AMOUNT DUE VENDOR         $ 168,017.67
- -----------------------------------------------------------------------------------------------------
                                                          TOTAL DRAW              $ 200,440.92
- -----------------------------------------------------------------------------------------------------
</TABLE>

Lessee Signature:          /s/                          Date:_______________
                  ------------------------

                                  Page 2 of 2
<PAGE>

                                    Schedule No. 03 to Lease
                                    Dated as of February 5, 1998
                                    Between SEQUENOM INC.
                                    and PHOENIX LEASING INCORPORATED

D.  Casualty Values:  See attachment hereto.
    ---------------

E.  Special Provisions: 1.  Lessor's payment for Equipment hereunder is
    ------------------
conditioned on Lessor's Satisfaction of the conditions set forth in Section 3 of
the Lease and 2. Sale Leaseback Addendum.

F.  End of Lease Position: (a) General.  Lessee shall be required to choose a
           ----- --------
final purchase or extension requirement ("End of Lease Position") at the
expiration of the Base Term (as defined in the Schedule) of the first Schedule
to the Lease.  That choice shall be an election of Lessee's End of Lease
Position for all, but not less than all, of the Equipment under all Schedules to
the Lease.  Lessee shall provide written notice of its election to Lessor at
least 90 days prior to the end of the Base Term of the first Schedule.
         -------------------------------------------------------------

Any Equipment purchase election shall be a purchase of the Equipment, AS-IS,
WHERE-IS.  Upon Lessor's receipt of the purchase price, Lessor shall issue to
Lessee, an equipment bill of sale, transferring title to the Equipment to the
Lessee without any representation or warranty whatsoever.  Lessee shall bc
responsible for all applicable taxes in connection with any Equipment purchase.

In the event Lessee does not provide at least 90 days' prior written notice of
its election, Lessee shall be deemed to have elected Election No. 2.

At the expiration of the Base Term of the first Schedule Lessee shall be
required to elect to either:

Election No. 1:  Purchase the Equipment for 25% of the Equipment's original
- --------------
purchase price; or

Election No. 2:  Extend the Schedule's Base Term for an additional 12 months
- --------------
("Extended Term") for a monthly rate of 2.50% of the Equipment's original
purchase price.

At the expiration of the Extended Term, Lessee shall purchase the Equipment for
$1.00.

LESSOR AND LESSEE AGREE THAT THIS SCHEDULE SHALL CONSTITUTE A LEASE OF THE
EQUIPMENT DESCRIBED ABOVE, SUBJECT TO THE TERMS AND CONDITIONS OF THIS SCHEDULE
AND OF THE MASTER EQUIPMENT LEASE DATED FEBRUARY 5, 1998 BETWEEN LESSEE AND
LESSOR.  THE TERMS AND CONDITIONS OF SUCH MASTER EQUIPMENT LEASE ARE HEREBY
INCORPORATED BY REFERENCE AND MADE A PART HEREOF TO THE SAME EXTENT AS IF SUCH
TERMS AND CONDITIONS WERE SET FORTH IN FULL HEREIN.

LESSOR:                                LESSEE:

PHOENIX LEASING INCORPORATED           SEQUENOM, INC.

By:    /s/ Lynn Sanders                By:            /s/  Stephen Zaniboni
   -------------------------------        --------------------------------------
Name:  Lynn Sanders                    Name (Print):
     -----------------------------                  ____________________________
Title: Contract Administrator          Title:
      ----------------------------           ___________________________________
Date:                                  Date:          April 29, 1998
     _____________________________          ------------------------------------

                                       2
<PAGE>

                                   SCHEDULE
                                   --------

                                                Schedule No. 04 to Lease
                                                Dated as of February 5, 1998
                                                Between SEQUENOM INC.
                                                and PHOENIX LEASING INCORPORATED

A.  Description and Purchase Price of Equipment
    -------------------------------------------

<TABLE>
<CAPTION>
       Description of
         Equipment
      (quantity, model                                                                 Street Address City,
     and serial number)       Purchase Price          Rent           Mfr./Vendor         State and County
    --------------------    -----------------     -----------     ----------------  ------------------------
    <S>                     <C>                   <C>             <C>               <C>
    See Exhibit A attached hereto.

    Total:                      $82,007.75         $2,230.61
</TABLE>

B.  Terms
    -----

Base Term:         The Base Term shall commence on the date the Equipment is
                   received, installed and accepted for use, as shown on the
                   Acceptance Notice, and continue for 42 full months after the
                   "Rent Start Date."

Rent Start Date:   This shall be the first day of the month following the month
                   during which the Base Term commences; provided, however, that
                   if the Equipment is accepted on the first day of the month,
                   the Rent Start Date shall commence on the same day that the
                   Base Term commences.

Lease Rate Factor (expressed as a percentage of Equipment's original Purchase
Price). 2.72%

Monthly Rental Payments in advance.

Base Rent Due:     Payable on the Rent Start Date shall be (1) the first and
                   last Rental Amount including any sales or use tax and (2) an
                   amount equal to 1/30th of the monthly rental amount using a
                   rate of 2.72% multiplied by the number of days, if any,
                   between (and including) the date the Base Term commences and
                   (but not including) the Rent Start Date, except that, if the
                   date of the Acceptance Notice related to this Schedule is
                   dated on or after the 20th of the month, this amount shall
                   not be included in the Base Rent Due.

C.   Invoice Information:  Lessee's and Lessor's addresses for invoice purposes
     -------------------
for the Equipment on the schedule be as follows:

Lessee's Invoice Address:               Remit Monthly Rental Amount To:
- ------------------------                ------------------------------
SEQUENOM, INC.                          PHOENIX LEASING INCORPORATED
11555 Sorrento Valley Road              P.O. Box 200432
San Diego, CA 92121                     Dallas, TX 75320-0432
Attention:  Mr. Steve Zaniboni, Vice President, Finance and Administration

                                       1
<PAGE>

                                                Schedule No. 04 to Lease
                                                Dated as of February 5, 1998
                                                Between SEQUENOM INC.
                                                and PHOENIX LEASING INCORPORATED

D.   Casualty Values: See attachment hereto.
     ---------------

E.   Special Provisions: 1. Lessor's payment for Equipment hereunder is
     ------------------
conditioned on Lessor's satisfaction of the conditions set forth in Section 3 of
the Lease and 2. Sale Leaseback Addendum.

F.   End of Lease Position: (a) General.  Lessee shall be required to choose a
     ---------------------      -------
     final purchase or extension requirement ("End of Lease Position") at the
     expiration of the Base Term (as defined in the Schedule) of the First
     Schedule to the Lease. That choice shall be an election of Lessee's End of
     Lease Position for all, but not less than all of the Equipment under all
     Schedules to the Lease. Lessee shall provide written notice of its election
     to Lessor at least 90 days prior to the end of the Base Term of the first
     Schedule.

Any Equipment purchase election shall be a purchase of the Equipment, AS-IS,
WHERE-IS. Upon Lessor's receipt of the purchase price, Lessor shall issue to
Lessee an equipment bill of sale, transferring title to the Equipment to the
Lessee without any representation or warranty whatsoever. Lessee shall be
responsible for all applicable taxes in connection with any Equipment Purchase.

In the event Lessee does not provide at least 90 days' prior written notice of
its election, Lessee shall be deemed to have elected Election No. 2.

At the expiration of the Base Term of the first Schedule Lessee shall be
required to elect to either:

Election No. 1: Purchase the Equipment for 25% of the Equipment's original
- --------------
purchase price; or

Election No. 2: Extend the Schedule's Base Term for an additional 12 months
- --------------
("Extended Term") for a monthly rate of 2.50% of the Equipment's original
purchase price.

At the expiration of the Extended Term, Lessee shall purchase the Equipment for
$1.00.

LESSOR AND LESSEE AGREE THAT THIS SCHEDULE SHALL CONSTITUTE A LEASE OF THE
EQUIPMENT DESCRIBED ABOVE, SUBJECT TO THE TERMS AND CONDITIONS OF THIS SCHEDULE
AND OF THE MASTER EQUIPMENT LEASE DATED FEBRUARY 5, 1998 BETWEEN LESSEE AND
LESSOR. THE TERMS AND CONDITIONS OF SUCH MASTER EQUIPMENT LEASE ARE HEREBY
INCORPORATED BY REFERENCE AND MADE A PART HEREOF TO THE SAME EXTENT AS IF SUCH
TERMS AND CONDITIONS WERE SET FORTH IN FULL HEREIN.

LESSOR:                                 LESSEE:

PHOENIX LEASING INCORPORATED            SEQUENOM, INC.

By:_____________________________        By:  /s/ Stephen Zaniboni
                                           -----------------------------
Name:___________________________        Name (Print): Stephen Zaniboni
                                                     -------------------
Title:__________________________        Title:  VP FINANCE
                                              --------------------------
Date:  April 29, 1998                   Date:  April 29, 1998
      --------------------------              --------------------------

                                  Page 2 of 1
                   Property of Phoenix Leasing Incorporated
<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A

     Lessee: SEQUENOM, INC.
             --------------------
            11555 SORRENTO VALLEY ROAD
            SAN DIEGO, CA 94121

<TABLE>
<CAPTION>
Master Contract:   0135                                                                        Schedule:   04
                 ---------                                                                              --------

- -----------------------------------------------------------------------------------------------------------------------
Vendor Name                                                                      L      Invoiced
(abbreviation         Invoice     Brief Description       Eqp   Serial           O      Amt Net of          Amt Paid
OK)                   No.         of Item                 Code  Number           C      Sales Tax           by Lesseee
- -----------------------------------------------------------------------------------------------------------------------
<S>                   <C>         <C>                     <C>   <C>              <C>    <C>                 <C>
MJ Research, Inc.     44432       Tetra Chassis (2)         24  TD002630         2         14,245.25        14,245.25
- -----------------------------------------------------------------------------------------------------------------------
MJ Research, Inc.     44432       ALPH BONNET QTY 4         24  ALO12790         2         15,822.00        15,622.00
- -----------------------------------------------------------------------------------------------------------------------
BECKMAN               331062FT01  Multimek 96 pipettor      24  304013ap         2         40,920.00
- -----------------------------------------------------------------------------------------------------------------------
BECKMAN                           multimek pro software     24                   2          4,650.00
- -----------------------------------------------------------------------------------------------------------------------
BECKMAN                           4 position labware        24                   2            790.50
- -----------------------------------------------------------------------------------------------------------------------
BECKMAN               33106FT02   Disposal Tip Wash         24  90007            2          5,580.00
- -----------------------------------------------------------------------------------------------------------------------

<CAPTION>
  Schedule:  04
           ------

- --------------------------------------------------------------------------------------------------------------
                                                                                 No entry required
Vendor Name                        Tax Pd                               --------------------------------------
(abbreviation         Invoice      Vendor      Check      Transact      Net $ Amt Due   Net $ Amt.
OK)                   No.          (Y/N)       No.           Date          Lessee       Due Vendor
- --------------------------------------------------------------------------------------------------------------
<S>                   <C>          <C>         <C>        <C>           <C>             <C>              <C>
MJ Research, Inc.     44432          Y         2482       3/12/98        $14,245.25     $      0.00      N
- --------------------------------------------------------------------------------------------------------------
MJ Research, Inc.     44432          Y         2482       3/12/98        $15,822.00     $      0.00      N
- --------------------------------------------------------------------------------------------------------------
BECKMAN               331062FT01                                         $     0.00     $ 40,920.00.     N
- --------------------------------------------------------------------------------------------------------------
BECKMAN                                                                  $     0.00     $  4,650.00      N
- --------------------------------------------------------------------------------------------------------------
BECKMAN                                                                  $     0.00     $    790.50      N
- --------------------------------------------------------------------------------------------------------------
BECKMAN               33106FT02                                          $     0.00     $  5,580.00      N
- --------------------------------------------------------------------------------------------------------------
                                                                         $     0.00     $      0.00    N/A
                                                                         -------------------------------------
                                          TOTAL AMOUNT DUE TO LESSEE     $30,067.25
                                                                         -------------------------------------
                                                         TOTAL AMOUNT DUE TO VENDOR     $ 51,940.50
                                                                                        ----------------------
                                                                         TOTAL DRAW     $ 82,007.75
                                                                                        ----------------------
</TABLE>

Lessee Signature: /s/ Stephen Zaniboni       Date:   April 29, 1998
                 -----------------------          ------------------

                                  Page 1 of 1
                   Property of Phoenix Leasing Incorporated
<PAGE>

                    ATTACHMENT TO EQUIPMENT SCHEDULE NO. 4

                                CASUALTY VALUES

<TABLE>
<CAPTION>
                Month of             % of Original Equipment         Month of             % of Original Equipment
               Lease Term                Purchase Price             Lease Term                Purchase Price
               ----------                --------------             ----------                --------------
               <S>                   <C>                            <C>                   <C>
                    1                        125.00                      22                         73.78
                    2                        122.56                      23                         71.34
                    3                        120.12                      24                         68.90
                    4                        117.68                      25                         66.46
                    5                        115.24                      26                         64.02
                    6                        112.80                      27                         61.59
                    7                        110.37                      28                         59.15
                    8                        107.93                      29                         56.71
                    9                        105.49                      30                         54.27
                   10                        103.05                      31                         51.83
                   11                        100.61                      32                         49.39
                   12                         98.17                      33                         46.95
                   13                         95.73                      34                         44.51
                   14                         93.29                      35                         42.07
                   15                         90.85                      36                         39.63
                   16                         88.41                      37                         37.20
                   17                         85.98                      38                         34.76
                   18                         83.54                      39                         32.32
                   19                         81.10                      40                         29.88
                   20                         78.66                      41                         27.44
                   21                         76.22                      42                         25.00
                                                                     Thereafter                     25.00
</TABLE>

Lessor's                                Lessee's
Initials (ILLEGIBLE)                    Initials (ILLEGIBLE)
         -----------                             -----------
<PAGE>

                               ACCEPTANCE NOTICE

                                SCHEDULE NO. 04

Reference is made to the Master Equipment Lease dated as of February 5, 1998
between PHOENIX LEASING INCORPORATED as Lessor and SEQUENOM, INC. as Lessee (the
"Lease").

Lessee confirms that the following Equipment has been received, installed and is
ready for use by Lessee.  The Equipment is satisfactory in all respects for the
purposes of this Lease as of the date Lessee executes this Notice below.

<TABLE>
<CAPTION>
          Description of Equipment
              (quantity, model                Purchase                 Mfr./          Street Address
             and serial number)                 Price       Rent       Vendor     City, State and County
             -----------------                  -----       ----       ------     ----------------------
         <S>                                  <C>           <C>        <C>        <C>
         See Exhibit A attached hereto.




         Total:                               $82,007.75    $2,230.61
</TABLE>

THE LEASE MAY NOT BE CHANGED, ALTERED OR MODIFIED EXCEPT BY AN INSTRUMENT IN
WRITING SIGNED BY AN OFFICER OF LESSOR AND A DULY AUTHORIZED REPRESENTATIVE OF
LESSEE.

IN WITNESS WHEREOF, Lessee has executed this Acceptance Notice as of April 29,
1998.


                                    SEQUENOM, INC.

                                    By:  /S/ STEPHEN ZANIBONI
                                       ------------------------------

                                    Name:  STEPHEN ZANIBONI
                                         ----------------------------

                                    Title:  VP FINANCE
                                          ---------------------------
<PAGE>

                                        SALE LEASEBACK ADDENDUM
                                        to Schedule No. 04
                                        of MASTER EQUIPMENT LEASE
                                        Dated as of February 5, 1998
                                        Between SEQUENOM, INC.
                                        and PHOENIX LEASING INCORPORATED


This Addendum to Master Equipment Lease is made and entered into as of April 29,
1998 between PHOENIX LEASING INCORPORATED ("Lessor") and SEQUENOM, INC.
("Lessee")

Notwithstanding anything to the contrary contained in the Lease referenced
above, Lessor and Lessee agree as follows:

1.   Lessee shall sell the Equipment to and lease the Equipment from Lessor and
     Lessor shall purchase the Equipment from and lease the Equipment to Lessee
     upon the terms and conditions of the Bill of Sale attached hereto as
     Attachment 1.

2.   Lessee represents and warrants that

     (a) Lessee has the right to sell the Equipment as set forth herein,

     (b) the Equipment and Lessee's right, title and interest in such Equipment
     is, as of the date of the Bill or Sale, free from all claims, liens,
     security interests and encumbrances,

     (c) Lessee will defend the sale against lawful claims and demands of all
     persons, and

     (d) the purchase price of the Equipment is equal to the fair market value
     of such Equipment at the time of sale.

LESSOR:                                      LESSEE:

PHOENIX LEASING INCORPORATED                 SEQUENOM, INC.

By: /s/ Lynn Sanders                         By: /s/ Stephen Zaniboni
   -----------------------------                ------------------------------
Name: Lynn Sanders                           Name (Print): Stephen Zaniboni
     ---------------------------                          --------------------
Title: Contract Administrator                Title: VP FINANCE
      --------------------------                   ---------------------------
<PAGE>

                                 ATTACHMENT 1
                                 BILL OF SALE

For valuable consideration SEQUENOM, INC. ("Seller") sells to PHOENIX LEASING
INCORPORATED ("Buyer"), the property listed on Exhibit A hereof (the
"Equipment").

Seller covenants and warrants that:

(1)  It is the owner of, and has absolute title to, the Equipment which is free
     and clear of all claims, liens and encumbrances.

(2)  It has not made any prior sale, assignment, or transfer of the Equipment.

(3)  It has the present right, power, and authority to sell the Equipment to
     Buyer.

(4)  All action has been taken which is required to make this Bill of Sale a
     legal, valid and binding obligation of Seller.

Seller shall forever warrant and defend the sale of Equipment to Buyer, its
successors and assigns, against any person claiming an interest in the
Equipment.

This Bill of Sale is binding on the successors and assigns of Seller and inures
to the benefit of the successors and assigns of Buyer.

Executed on April 29, 1998


                                             SEQUENOM, INC.

                                             By: /s/ Stephen Zaniboni
                                                ------------------------------
                                             Name (Print): Stephen Zaniboni
                                                          --------------------
                                             Title: VP FINANCE
                                                   ---------------------------
<PAGE>

                             OFFICER'S CERTIFICATE
                             ---------------------

The undersigned, ___________________________, hereby certifies that:

i)    I am the Treasurer/Chief Financial Officer of SEQUENOM, INC., a Delaware
      corporation:

ii)   as such officer, I am familiar with the terms and conditions of that
      certain Master Equipment Lease (the "Lease") dated as of February 5, 1998
      between SEQUENOM, INC. ("Lessee") and PHOENIX LEASING INCORPORATED
      ("Lessor");

iii)  this certificate is delivered in connection with the leasing of certain
      equipment under a Schedule with Lessor, the equipment is described in the
      Schedule and the equipment is free and clear from any and all liens,
      charges, security interests or other encumbrances which may affect
      Lessor's right, title or interest in and to the equipment.

iv)   there has been no material adverse change in the financial condition of
      Lessee from the date of its most recent financial statements, true copies
      of which have been delivered to Lessor, and

v)    no event which, with the giving of notice or passage of time, or both,
      could become an Event of Default under the Lease has occurred and is
      continuing.

(vi)  Lessee is performing according to Lessee's business plan described in
      Section 3 of the Lease, a true copy of which business plan has been
      delivered to Lessor;

(vii) the representations and warranties in Section 5 of the Lease are true and
      correct as of the date hereof.

IN WITNESS WHEREOF, I hereby execute this certificate on this 29 day of April,
1998.



                                             /s/ Stephen Zaniboni
                                             -----------------------------
<PAGE>

                                   SCHEDULE
                                   --------

                                      Schedule No. 05 to Lease
                                      Dated as of February 5, 1998
                                      Between SEQUENOM INC.
                                      and PHOENIX LEASING INCORPORATED


A.   Description and Purchase Price of Equipment
     -------------------------------------------

     Description of
      Equipment
     (quantity, model                                      Street Address City,
    and serial number)  Purchase Price  Rent  Mfr./Vendor    State and County
    ------------------  --------------  ----  -----------  --------------------

     See Exhibit A attached hereto.

     Total:             $76,861.21     $2,090.62

B.   Terms
     -----

Base Term:       The Base Term shall commence on the date the Equipment is
                 received, installed and accepted for use, as shown on the
                 Acceptance Notice, and continue for 42 full months after the
                 "Rent Start Date."

Rent Start Date: This shall be the first day of the month following the month
                 during which the Base Term commences; provided, however, that
                 if the Equipment is accepted on the first day of the month, the
                 Rent Start Date shall commence on the same day that the Base
                 Term commences.

Lease Rate Factor (expressed as a percentage of Equipment's original Purchase
Price): 2.72%

Monthly Rental Payments in advance.

Base Rent Due:   Payable on the Rent Start Date shall be (1) the first and last
                 Rental Amount including any sales or use tax and (2) an amount
                 equal to 1/30th of the monthly rental amount using a rate of
                 2.72% multiplied by the number of days, if any, between (and
                 including) the date the Base Term commences and (but not
                 including) the Rent Start Date, except that, if the date of the
                 Acceptance Notice related to this Schedule is dated on or after
                 the 20th of the month, this amount shall not be included in the
                 Base Rent Due.

C.   Invoice Information:  Lessee's and Lessor's addresses for invoice purposes
     -------------------
for the Equipment on the schedule be as follows:


Lessee's Invoice Address:              Remit Monthly Rental Amount To:
- ------------------------               ------------------------------
SEQUENOM, INC.                         PHOENIX LEASING INCORPORATED
11555 Sorrento Valley Road             P.O. Box 200432
San Diego, CA 92121                    Dallas, TX 75320-0432
Attention:  Mr. Steve Zaniboni, Vice President, Finance and Administration

                                       1
<PAGE>

                                         Schedule No. 05 to Lease
                                         Dated as of February 5, 1998
                                         Between SEQUENOM INC.
                                         and PHOENIX LEASING INCORPORATED

D.   Casualty Values: See attachment hereto.
     ---------------

E.   Special Provisions: 1. Lessor's payment for Equipment hereunder is
     ------------------
conditioned on Lessor's satisfaction of the conditions set forth in Section 3 of
the Lease and 2. Sale Leaseback Addendum.

F.   End of Lease Position:(a) General.  Lessee shall be required to choose a
     ---------------------     -------
final purchase or extension requirement ("End of Lease Position") at the
expiration of the Base Term (as defined in the Schedule) of the First Schedule
to the Lease. That choice shall be an election of Lessee's End of Lease Position
for all, but not less than all of the Equipment under all Schedules to the
Lease. Lessee shall provide written notice of its election to Lessor at least 90
days prior to the end of the Base Term of the first Schedule.

Any Equipment purchase election shall be a purchase of the Equipment, AS-IS,
WHERE-IS. Upon Lessor's receipt of the purchase price, Lessor shall issue to
Lessee an equipment bill of sale, transferring title to the Equipment to the
Lessee without any representation or warranty whatsoever. Lessee shall be
responsible for all applicable taxes in connection with any Equipment Purchase.

In the event Lessee does not provide at least 90 days' prior written notice of
its election, Lessee shall be deemed to have elected Election No. 2.

At the expiration of the Base Term of the first Schedule Lessee shall be
required to elect to either:

Election No. 1:  Purchase the Equipment for 25% of the Equipment's original
- --------------
purchase price; or

Election No. 2:  Extend the Schedule's Base Term for an additional 12 months
- --------------
("Extended Term") for a monthly rate of 2.50% of the Equipment's original
purchase price.

At the expiration of the Extended Term, Lessee shall purchase the Equipment for
$1.00.

LESSOR AND LESSEE AGREE THAT THIS SCHEDULE SHALL CONSTITUTE A LEASE OF THE
EQUIPMENT DESCRIBED ABOVE, SUBJECT TO THE TERMS AND CONDITIONS OF THIS SCHEDULE
AND OF THE MASTER EQUIPMENT LEASE DATED FEBRUARY 5, 1998 BETWEEN LESSEE AND
LESSOR. THE TERMS AND CONDITIONS OF SUCH MASTER EQUIPMENT LEASE ARE HEREBY
INCORPORATED BY REFERENCE AND MADE A PART HEREOF TO THE SAME EXTENT AS IF SUCH
TERMS AND CONDITIONS WERE SET FORTH IN FULL HEREIN.

LESSOR:                                   LESSEE:

PHOENIX LEASING INCORPORATED              SEQUENOM, INC.

By:    /s/ Lynn Sanders                   By:  /s/ Stephen Zaniboni
   -------------------------------           -------------------------------
Name:  Lynn Sanders                       Name (Print): Stephen Zaniboni
     -----------------------------                     ---------------------
Title: Contract Administrator             Title:  VP FINANCE
      ----------------------------              ----------------------------
Date:  May 1, 1998                        Date: May 1, 1998
     -----------------------------             -----------------------------
<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A

 Lessee:  SEQUENOM, INC.
          ----------------------
          11555 SORRENTO VALLEY ROAD
          SAN DIEGO, CA 94121

Master Contract:       0135                                   Schedule:    05
                     ---------                                          --------

<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------------------------------
Vendor Name                                                                         L      Invoiced
(abbreviation          Invoice      Brief Description         Eqp         Serial    O     Amt Net of    Amt Paid
 OK)                   No.          of Item                   Code       Number     C     Sales Tax    by Lessee
- -----------------------------------------------------------------------------------------------------------------------
<S>                   <C>          <C>                       <C>        <C>         <C>  <C>           <C>
WATERS                263025832    996 Detector lamp assy       2                   1         555.00
- -----------------------------------------------------------------------------------------------------------------------
                                   freight                     27                   1           5.00
- -----------------------------------------------------------------------------------------------------------------------
Micron                  1672002    COM 512K PIPELINE            1                   1       2,017.00       2,017.00
- -----------------------------------------------------------------------------------------------------------------------
Western Telematic         75628    8 Ports code Activated       2          97236    1         445.00
- -----------------------------------------------------------------------------------------------------------------------
                                   freight                     27                   1           5.25
- -----------------------------------------------------------------------------------------------------------------------
Micron                  1672002    freight                     27                   1          99.00          99.00
- -----------------------------------------------------------------------------------------------------------------------
Perkins Elmers         90131208    Amo II TAG GOLD              2                   1       1,864.20
- -----------------------------------------------------------------------------------------------------------------------
                                   freight                     27                   1          32.50
- -----------------------------------------------------------------------------------------------------------------------
MICRON                  1672002    SALES TAX                   29                   1         156.32         156.32
- -----------------------------------------------------------------------------------------------------------------------
FISCHER                 1619386    FREEZER                      2                   1       4,674.79
- -----------------------------------------------------------------------------------------------------------------------
Insulator Seal Inc        63899    COVER HV 0.51-071            2                   1         354.00
- -----------------------------------------------------------------------------------------------------------------------
                                   freight                     27                   1           9.75
- -----------------------------------------------------------------------------------------------------------------------
TECAN US INC             133321    LIQUID HANDLING SYS          2                   1      65,908.40
- -----------------------------------------------------------------------------------------------------------------------
                                   freight                     27                   1         500.00
- -----------------------------------------------------------------------------------------------------------------------
TECAN US INC             133435    LIQUID HANDLING SYS          2                   1         235.00
- -----------------------------------------------------------------------------------------------------------------------

<CAPTION>
- -------------------------------------------------------------------------------------------------------
                                  Tax Pd                                   No entry required
                                                                  -------------------------------------
Vendor Name
(abbreviation          Invoice    Vendor     Check      Transact       Net $ Amt      Net $ Amt.
 OK)                   No.         (Y/N)     No.            Date      Due Lessee      Due Vendor
- -------------------------------------------------------------------------------------------------------
<S>                   <C>         <C>        <C>        <C>           <C>            <C>           <C>
WATERS                263025832   N                        3/24/98      $    0.00    $   555.00    N
                                  N                        4/10/98      $    0.00    $     5.00    N
- -------------------------------------------------------------------------------------------------------
Micron                  1672002   Y                        4/10/98      $2,017.00    $     0.00    N
- -------------------------------------------------------------------------------------------------------
Western Telematic         75628   N                        4/10/98      $    0.00    $   445.00    N
- -------------------------------------------------------------------------------------------------------
                                  N                        4/10/98      $    0.00    $     5.25    N
- -------------------------------------------------------------------------------------------------------
Micron                  1672002   Y                        4/10/98      $   99.00    $     0.00    N
- -------------------------------------------------------------------------------------------------------
Perkins Elmers         90131208   N                         7/7/97      $    0.00    $ 1,864.20    N
- -------------------------------------------------------------------------------------------------------
                                  N                         7/7/97      $    0.00    $    32.50    N
- -------------------------------------------------------------------------------------------------------
MICRON                  1672002   N                        4/10/98      $  156.32    $     0.00    N
- -------------------------------------------------------------------------------------------------------
FISCHER                 1619386   N                        3/31/98      $    0.00    $ 4,674.79    N
- -------------------------------------------------------------------------------------------------------
Insulator Seal Inc        63899   N                        3/26/98      $    0.00    $   354.00    N
- -------------------------------------------------------------------------------------------------------
                                  N                        3/26/98      $    0.00    $     9.75    N
- -------------------------------------------------------------------------------------------------------
TECAN US INC             133321   N                        3/11/98      $    0.00    $65,908.40    N
- -------------------------------------------------------------------------------------------------------
                                  N                        3/11/98      $    0.00    $   500.00    N
- -------------------------------------------------------------------------------------------------------
TECAN US INC             133435   N                        3/27/98      $    0.00    $   235.00    N
- -------------------------------------------------------------------------------------------------------
                                        $    0.00    $     0.00  N/A
- -----------------------------------------------------------------------
     TOTAL AMOUNT DUE TO LESSEE         $2,272.32
                                        -------------------------------
                            TOTAL AMOUNT TO VENDOR   $74,588.89
                                                     ------------------
                                        TOTAL DRAW   $76,861.21
                                                     ------------------
</TABLE>

Lessee Signature:  /s/ Stephen Zaniboni                          Date:  5/1/98
                  ----------------------------------                   --------




                          Page 1 of 1

                  Property of Phoenix Leasing Incorporated
<PAGE>

                        ADDITIONAL COMMITMENT SCHEDULE
                        ------------------------------


                                Schedule (Additional Commitment) No. 06 to Lease
                                Dated as of February 5, 1998
                                Between SEQUENOM, INC.
                                and PHOENIX LEASING INCORPORATED


A.  Description and Purchase Price of Equipment
    -------------------------------------------

<TABLE>
<CAPTION>
   Description of
      Equipment                                                                    Street Address
  (quantity, model                                                                 City, State and
 and serial number)    Purchase Price          Rent            Mfr./ Vendor            County
- -----------------------------------------------------------------------------------------------------
<S>                    <C>                   <C>               <C>                 <C>
See Exhibit A attached hereto

Total:                  $240,627.44          $6,545.07
</TABLE>

B.  Terms
    -----

Base Term:          The Base Term shall commence on the date the Equipment is
                    received, installed and accepted for use, as shown on the
                    Acceptance Notice, and continue for 42 full months after the
                    "Rent Start Date."

Rent Start Date:    This shall be the first day of the month following the month
                    during which the Base Term commences; provided, however,
                    that if the Equipment is accepted on the first day of the
                    month, the Rent Start Date shall commence on the same day
                    that the Base Term commences.

Lease Rate Factor: (expressed as a percentage of Equipment's original Purchase
                    Price): 2.72%

Monthly Rental Payments in advance

Base Rent Due:      Payable on the Rent Start Date shall be (1) the first and
                    last Rental Amount including any sales of use tax and (2) an
                    amount equal to 1/30th of the monthly rental amount using a
                    rate of 2.72% multiplied by the number of days, if any,
                    between (and including) the date the Base Term commences and
                    (but not including) the Rent Start Date, except that, if the
                    date of the Acceptance Notice related to this Schedule is
                    dated on or after the 20th of the month, this amount shall
                    not be included in the Base Rent Due.
<PAGE>

                                Schedule (Additional Commitment) No. 06 to Lease
                                Dated as of February 5, 1998
                                Between SEQUENOM, INC.
                                and PHOENIX LEASING INCORPORATED


C.   Invoice Information: Lessee's and Lessor's addresses for invoice purposes
     --------------------
for the Equipment on the Schedule shall be as follows:

Lessee's Invoice Address:               Remit Monthly Rental Amount To:
- ------------------------                ------------------------------
SEQUENOM, INC.                          PHOENIX LEASING INCORPORATED
11555 Sorento Valley Road               P.O. Box 200432
San Diego, CA 92121                     Dallas, TX 75320-0432
Attention: Mr. Steve Zaniboni, Vice President, Finance and Administration

D.   Casualty Values: See attachment hereto.
     ----------------

E.   Special Provisions: 1. Lessor's payment for Equipment hereunder is
     -------------------
conditioned on Lessor's satisfaction of the conditions set forth in Section 3 of
the Lease and 2. Sale Leaseback Addendum.

F.   End of Lease Position: (a) General. Lessee shall be required to choose a
     ----------------------     --------
final purchase or extension requirement ("End of Lease Position") at the
expiration of the Base Term (as defined in the Schedule) of the first Schedule
to the Lease.  That choice shall be an election of Lessee's End of Lease
Position for all, but not less than all, of the Equipment under all Schedules to
the Lease.  Lessee shall provide written notice of its election to Lessor at
least 90 days prior to the end of the Base Term of the first Schedule.

Any Equipment purchase election shall be a purchase of the Equipment, AS-IS,
WHERE-IS.  Upon Lessor's receipt of the purchase price, Lessor shall issue to
Lessee an equipment bill of sale, transferring title to the Equipment to the
Lessee without any representation or warranty whatsoever.  Lessee shall be
responsible for all applicable taxes in connection with any Equipment purchase.

In the event Lessee does not provide at least 90 days' prior written notice of
its election, Lessee shall be deemed to have elected Election No. 2.

At the expiration of the Base Term of the first Schedule Lessee shall be
required to elect to either:

Election No. 1:     Purchase the Equipment for 25% of the Equipment's original
- ---------------
purchase price; or

Election No. 2:     Extend the Schedule's Base Term for an additional 12 months
- ---------------
("Extended Term") for a monthly rate of 2.50% of the Equipment's original
purchase price.

At the expiration of the Extended Term, Lessee shall purchase the Equipment for
$1.00.

LESSOR AND LESSEE AGREE THAT THIS SCHEDULE SHALL CONSTITUTE A LEASE OF THE
EQUIPMENT DESCRIBED ABOVE, SUBJECT TO THE TERMS AND
<PAGE>

                                Schedule (Additional Commitment) No. 06 to Lease
                                Dated as of February 5, 1998
                                Between SEQUENOM, INC.
                                and PHOENIX LEASING INCORPORATED

CONDITIONS OF THIS SCHEDULE AND OF THE MASTER EQUIPMENT LEASE DATED FEBRUARY 5,
1998 BETWEEN LESSEE AND LESSOR. THE TERMS AND CONDITIONS OF SUCH MASTER
EQUIPMENT LEASE ARE HEREBY INCORPORATED BY REFERENCE AND MADE A PART HEREOF TO
THE SAME EXTENT AS IF SUCH TERMS AND CONDITIONS WERE SET FORTH IN FULL HEREIN.

LESSOR:                                  LESSEE:

PHOENIX LEASING INCORPORATED             SEQUENOM, INC.

By:    /s/ Lynn Sanders                  By:     /s/ Stephen Zaniboni
   -------------------------------          -----------------------------------
Name:  Lynn Sanders                      Name (Print):  Steven Zaniboni
     -----------------------------                    -------------------------
Title: Contract Administrator            Title:         VP Finance
      ----------------------------             --------------------------------
Date:  2-1-99                            Date:          2-1-99
     -----------------------------            ---------------------------------
<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A

Lessee:  Sequenom, Inc.
         --------------

         11555 SORRENTO VALLEY ROAD
         SAN DIEGO, CA  94121

Master Contract: 0135                     Schedule:   06
                 ----                               ------

<TABLE>
<CAPTION>
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                               L      Invoiced Amt                  Tax Pd   Check
Vendor Name                                                   Eqp    Serial    O      Net of Sales     Amt Paid     Vendor?   No.
(abbreviation OK)    Invoice No.  Brief Description of Item  Code    Number    C          Tax          By Lessee     (Y/N)
- ----------------------------------------------------------------------------------------------------------------------------------
<S>                  <C>          <C>                        <C>     <C>       <C>    <C>              <C>          <C>      <C>
VAT                  3847         GATE VALVE                  2                 1       1,365.00                    N
- ----------------------------------------------------------------------------------------------------------------------------------
A-1 Furniture        34913        2-om41                      6                 1         279.98                    N
- ----------------------------------------------------------------------------------------------------------------------------------
                                  2-om44                      6                 1         279.98                    N
- ----------------------------------------------------------------------------------------------------------------------------------
                                  3-om100                     6                 1         281.25                    N
- ----------------------------------------------------------------------------------------------------------------------------------
A-1 Furniture        34906        3-om42                      6                 1         329.97                    N
- ----------------------------------------------------------------------------------------------------------------------------------
                                  3-om41                      6                 1         419.97                    N
- ----------------------------------------------------------------------------------------------------------------------------------
NECX                 646105       MAGICOLOR                   1                 1       4,499.95                    N
- ----------------------------------------------------------------------------------------------------------------------------------
                                  freight                    27                 1          41.53                    N
- ----------------------------------------------------------------------------------------------------------------------------------
NECX                 638039       KTM8X32L                    1                 1         223.90                    N
- ----------------------------------------------------------------------------------------------------------------------------------
NECX                 646405       OFFICECONNECT               1                 1         113.90                    N
- ----------------------------------------------------------------------------------------------------------------------------------
                                  freight                    27                 1           6.36                    N
- ----------------------------------------------------------------------------------------------------------------------------------
NECX                 646651       OFFICE 97                  24                 1         519.95                    N
- ----------------------------------------------------------------------------------------------------------------------------------
                                  freight                    27                 1           3.95                    N
- ----------------------------------------------------------------------------------------------------------------------------------
NECX                 637747       WINDOWS NT                 24                 1         271.95                    N
- ----------------------------------------------------------------------------------------------------------------------------------
                                  freight                    27                 1           5.45                    N
- ----------------------------------------------------------------------------------------------------------------------------------
NECX                 639241       32MB ECC                    1                 1         197.90                    N
- ----------------------------------------------------------------------------------------------------------------------------------
                                  freight                    27                 1           3.95                    N
- ----------------------------------------------------------------------------------------------------------------------------------
ARENSON              153239       CLASS CONF TABLE            6                 1         225.00                    N
- ----------------------------------------------------------------------------------------------------------------------------------
FISCHER              2015210      UTILITY CART                2                 1         150.00                    N
- ----------------------------------------------------------------------------------------------------------------------------------
                                  DRYING RACK                 2                 1         132.02                    N
- ----------------------------------------------------------------------------------------------------------------------------------
FISCHER              2015209      COOLR LAB                   2                 1         240.00                    N
- ----------------------------------------------------------------------------------------------------------------------------------
GA GE                u98-0138     Generator for ibm pc        2                 1       2,245.00                    N
- ----------------------------------------------------------------------------------------------------------------------------------
                                  freight                    27                 1          75.00                    n
- ----------------------------------------------------------------------------------------------------------------------------------
National Inst        424592       labwindows                 24                 1       1,995.00                    n
- ----------------------------------------------------------------------------------------------------------------------------------
mcfrugals   lab      12655        well reversible racks       2                 1         978.00                    n
- ----------------------------------------------------------------------------------------------------------------------------------
                                  freight                    27                 1           4.95                    n
- ----------------------------------------------------------------------------------------------------------------------------------
Robocon              8            Robolab                     2                 1       7,925.44                    n
- ----------------------------------------------------------------------------------------------------------------------------------
office depot         50050814010  napoli blk                  6      AD         1         199.99            199.99  y        amex
- ----------------------------------------------------------------------------------------------------------------------------------
Arenson              00153032     lazyboy lateral file        6                 1         870.00            870.00  y        2767
- ----------------------------------------------------------------------------------------------------------------------------------
ARENSON              00152857     bookcase                    6                 1         885.00            885.00  y        2669
- ----------------------------------------------------------------------------------------------------------------------------------
ARENSON              48951        2 bookcases                 6                 1       1,770.00          1,770.00  y        2628
- ----------------------------------------------------------------------------------------------------------------------------------
                                  conf table                  6                 1       1,335.00          1,335.00  y        2628
- ----------------------------------------------------------------------------------------------------------------------------------

<CAPTION>
- -------------------------------------------------------------------------
                                                       No entry required
                                                 --------------------------------
Vendor Name                           Transact      Net $ Amt   Net $ Amt     P
(abbreviation OK)    Invoice No.        Date       Due Lessee  Due Vendor
- ---------------------------------------------------------------------------------
<S>                  <C>              <C>        <C>          <C>             <C>
VAT                  3847              5/5/98    $    0.00    $  1,365.00     N
- ---------------------------------------------------------------------------------
A-1 Furniture        34913             4/17/98   $    0.00    $    279.98     N
- ---------------------------------------------------------------------------------
                                       4/17/98   $    0.00    $    279.98     N
- ---------------------------------------------------------------------------------
                                       4/17/98   $    0.00    $    281.25     N
- ---------------------------------------------------------------------------------
A-1 Furniture        34906             4/15/98   $    0.00    $    329.97     N
- ---------------------------------------------------------------------------------
                                       4/24/98   $    0.00    $    419.97     N
- ---------------------------------------------------------------------------------
NECX                 646105             5/7/98   $    0.00    $  4,499.95     N
- ---------------------------------------------------------------------------------
                                        5/7/98   $    0.00    $     41.53     N
- ---------------------------------------------------------------------------------
NECX                 638039             5/7/98   $    0.00    $    223.90     N
- ---------------------------------------------------------------------------------
NECX                 646405             5/7/98   $    0.00    $    113.90     N
- ---------------------------------------------------------------------------------
                                       4/24/98   $    0.00    $      6.36     N
- ---------------------------------------------------------------------------------
NECX                 646651            4/24/98   $    0.00    $    519.95     N
- ---------------------------------------------------------------------------------
                                        5/7/98   $    0.00    $      3.95
- ---------------------------------------------------------------------------------
NECX                 637747             5/7/98   $    0.00    $    271.95     N
- ---------------------------------------------------------------------------------
                                        5/7/98   $    0.00    $      5.45     N
- ---------------------------------------------------------------------------------
NECX                 639241            4/28/98   $    0.00    $    197.90     N
- ---------------------------------------------------------------------------------
                                       4/28/98   $    0.00    $      3.95     N
- ---------------------------------------------------------------------------------
ARENSON              153239            4/30/98   $    0.00    $    225.00     N
- ---------------------------------------------------------------------------------
FISCHER              2015210           4/27/98   $    0.00    $    150.00     N
- ---------------------------------------------------------------------------------
                                       4/27/98   $    0.00    $    132.02     N
- ---------------------------------------------------------------------------------
FISCHER              2015209           4/27/98   $    0.00    $    240.00     N
- ---------------------------------------------------------------------------------
GA GE                u98-0138          4/28/98   $    0.00    $  2,245.00     N
- ---------------------------------------------------------------------------------
                                       4/28/98   $    0.00    $     75.00     N
- ---------------------------------------------------------------------------------
National Inst        424592            4/29/98   $    0.00    $  1,995.00     N
- ---------------------------------------------------------------------------------
mcfrugals   lab      12655             4/21/98   $    0.00    $    978.00     N
- ---------------------------------------------------------------------------------
                                       4/21/98   $    0.00    $      4.95     N
- ---------------------------------------------------------------------------------
Robocon              8                 3/31/98   $    0.00    $117,925.44     N
- ---------------------------------------------------------------------------------
office depot         50050814010       3/23/98   $  199.99    $      0.00     N
- ---------------------------------------------------------------------------------
Arenson              00153032          4/22/98   $  870.00    $      0.00     N
- ---------------------------------------------------------------------------------
ARENSON              00152857           4/9/98   $  885.00    $      0.00     N
- ---------------------------------------------------------------------------------
ARENSON              48951             3/27/98   $1,770.00    $      0.00     N
- ---------------------------------------------------------------------------------
                                       3/27/98   $1,335.00    $      0.00     N
- ---------------------------------------------------------------------------------
</TABLE>
<PAGE>

<TABLE>
- ----------------------------------------------------------------------------------------------------------------------------------
<S>                        <C>    <C>                             <C>              <C>       <C>          <C>       <C> <C>
arenson                    30628  office furniture                6                1         1,744.00     1,744.00  y         amex
- ----------------------------------------------------------------------------------------------------------------------------------
vantage                     1467  oval table                      6                1           300.00       300.00  y         amex
- ----------------------------------------------------------------------------------------------------------------------------------
vantage                    43311  sofa/blk leather                6                1         1,349.00     1,349.00  y         amex
- ----------------------------------------------------------------------------------------------------------------------------------
vantage                    43239  3 desk chairs                   6                1           957.60       957.60  y         amex
- ----------------------------------------------------------------------------------------------------------------------------------
                                  freight                        27                1            50.00        50.00  y         amex
- ----------------------------------------------------------------------------------------------------------------------------------
ll-cor                    061786  ibm compatible comp             1                1         5,210.00     5,210.00  n         2732
- ----------------------------------------------------------------------------------------------------------------------------------
rlha                    97074019  leasehold                      23                1        10,575.30    10,575.30  n         2860
- ----------------------------------------------------------------------------------------------------------------------------------
rlha                    97074019  leasehold                      23                1        22,636.20    22,636.20  n         2821

- ----------------------------------------------------------------------------------------------------------------------------------

- ----------------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------
<S>                     <C>             <C>         <C>          <C>            <C>
arenson                    30628        3/23/98     $ 1,744.00   $      0.00    N
- ---------------------------------------------------------------------------------
vantage                     1467         3/9/98     $   300.00   $      0.00    N
- ---------------------------------------------------------------------------------
vantage                    43311         3/9/98     $ 1,349.00   $      0.00
- ---------------------------------------------------------------------------------
vantage                    43239         3/6/98     $   957.60   $      0.00    N
- ---------------------------------------------------------------------------------
                                         3/6/98     $    50.00   $      0.00    N
- ---------------------------------------------------------------------------------
ll-cor                    061786        4/20/98     $ 5,210.00   $      0.00    N
- ---------------------------------------------------------------------------------
rlha                    97074019         5/4/98     $10,575.30   $      0.00    N
- ---------------------------------------------------------------------------------
rlha                    97074019        4/28/99     $22,636.20   $      0.00    N

- ---------------------------------------------------------------------------------
- ---------------------------------------------------------------------------------
                                                    ------------------------
                                                    $47,812.09
                                                    ------------------------
                                                                 $192,815.35
                                                                 -----------
                                                                 $240,627.44
                                                                 -----------
</TABLE>

     Lessee Signature:  /s/ Stephen Zaniboni       Date: May 27, 1998
                        --------------------             ------------

<PAGE>

                                   SCHEDULE
                                   --------

                                        Schedule No. 07 to Lease
                                        Dated as of February 5, 1998
                                        Between SEQUENOM, INC.
                                       and PHOENIX LEASING INCORPORATED

A.   Description and Purchase Price of Equipment
     -------------------------------------------

   Description of
     Equipment
   (quantity, model      Purchase                Mfr./        Street Address
  and serial number)       Price      Rent      Vendor    City, State and County
- ----------------------  ----------- ---------  --------  -----------------------

     See Exhibit A attached hereto.
Total:                  $86,961.81  $2,365.36

B.   Terms
     -----

Base Term:        The Base Term shall commence on the date the Equipment is
                  received, installed and accepted for use, as shown on the
                  Acceptance Notice, and continue for 42 full months after the
                  "Rent Start Date."

Rent Start Date:  This shall be the first day of the month following the month
                  during which the Base Term commences; provided, however, that
                  if the Equipment is accepted on the first day of the month,
                  the Rent Start Date shall commence on the same day that the
                  Base Term commences.

Lease Rate Factor (expressed as a percentage of Equipment's original Purchase
Price): 2.72%

Monthly Rental Payments in advance.

Base Rent Due:    Payable on the Rent Start Date shall be (1) the first and last
                  Rental Amount including any sales or use tax and (2) an amount
                  equal to 1/30th of the monthly rental amount using a rate of
                  2.72% multiplied by the number of days, if any, between (and
                  including) the date the Base Term commences and (but not
                  including) the Rent Start Date, except that, if the date of
                  the Acceptance Notice related to this Schedule is dated on or
                  after the 20th of the month, this amount shall not be included
                  in the Base Rent Due.

C.   Invoice Information:  Lessee's and Lessor's addresses for invoice purposes
     -------------------
for the Equipment on the Schedule shall be as follows:

Lessee's Invoice Address:                     Remit Monthly Rental Amount To:
- ------------------------                      ------------------------------
SEQUENOM, INC.                                PHOENIX LEASING INCORPORATED
11555 Sorento Valley Road                     P.O. Box 200432
San Diego, CA 92121                           Dallas, TX 75320-0432
Attention:  Mr. Steve Zaniboni, Vice President, Finance and Administration

<PAGE>

                                                Schedule No. 07 to Lease
                                                Dated as of February 5, 1998
                                                Between SEQUENOM, INC.
                                                and PHOENIX LEASING INCORPORATED

D.   Casualty Values: See attachment hereto.
     ---------------

E.   Special Provisions:  1.  Lessor's payment for Equipment hereunder is
     ------------------
conditioned on Lessor's satisfaction of the conditions set forth in Section 3 of
the Lease and 2. Sale Leaseback Addendum.

F.   End of Lease Position:  (a) General.  Lessee shall be required to choose a
     ---------------------       -------
final purchase or extension requirement ("End of Lease Position") at the
expiration of the Base Term (as defined in the Schedule) of the first Schedule
to the Lease. That choice shall be an election of Lessee's End of Lease Position
for all, but not less than all, of the Equipment under all Schedules to the
Lease. Lessee shall provide written notice of its election to Lessor at least 90
days prior to the end of the Base Term of the first Schedule.

Any Equipment purchase election shall be a purchase of the Equipment, AS-IS,
WHERE-IS. Upon Lessor's receipt of the purchase price, Lessor shall issue to
Lessee an equipment bill of sale, transferring title to the Equipment to the
Lessee without any representation or warranty whatsoever. Lessee shall be
responsible for all applicable taxes in connection with any Equipment purchase.

In the event Lessee does not provide at least 90 days' prior written notice of
its election, Lessee shall be deemed to have elected Election No. 2.

At the expiration of the Base Term of the first Schedule Lessee shall be
required to elect to either:

Election No. 1: Purchase the Equipment for 25% of the Equipment's original
- --------------
purchase price; or

Election No. 2: Extend the Schedule's Base Term for an additional 12 months
- --------------
("Extended Term") for a monthly rate of 2.50% of the Equipment's original
purchase price.

At the expiration of the Extended Term, Lessee shall purchase the Equipment for
$ 1.00.

LESSOR AND LESSEE AGREE THAT THIS SCHEDULE SHALL CONSTITUTE A LEASE OF THE
EQUIPMENT DESCRIBED ABOVE, SUBJECT TO THE TERMS AND CONDITIONS OF TIES SCHEDULE
AND OF THE MASTER EQUIPMENT LEASE DATED FEBRUARY 5, 1998 BETWEEN LESSEE AND
LESSOR.  THE TERMS AND CONDITIONS OF SUCH MASTER EQUIPMENT LEASE ARE HEREBY
INCORPORATED BY REFERENCE AND MADE A PART HEREOF TO THE SAME EXTENT AS IF SUCH
TERMS AND CONDITIONS WERE SET FORTH IN FULL HEREIN.

LESSOR:                                  LESSEE:

PHOENIX LEASING INCORPORATED             SEQUENOM, INC.

By:    /s/     Lynn Sanders              By:      /s/   Stephen Zaniboni
       ------------------------------           ------------------------------
Name:  Lynn Sanders                      Name (Print):  Stephen Zaniboni
       ------------------------------                 ------------------------
Title: Contract Administrator            Title: VP Finance
       ------------------------------           ------------------------------
Date:  ______________________________    Date:  6/29/98
                                                ------------------------------

                                       2

<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A

<TABLE>
<CAPTION>
        Lesseee: SEQUENOM, INC.
                 --------------------------
                 11555 SORRENTO VALLEY RD.
MASTER CONTRACT: 0135
                 --------------------------

- -----------------------------------------------------------------------------------------------------------------------------------

                                                                                                                     Total
 Item                                        Invoice   Description                      Eq        Serial             Invoic'd $
 No.       Vendor Name                       No.       of Item                          Cd   Qty   Number Loc   Net of Sales Tax
- -----------------------------------------------------------------------------------------------------------------------------------
<S>       <C>                                <C>       <C>                              <C>  <C>  <C>     <C>  <C>
- -----------------------------------------------------------------------------------------------------------------------------------
   1       SRS                               75690-R   Gas Analyzer                      2    1            1         4,000.00
- -----------------------------------------------------------------------------------------------------------------------------------
   2       Micron Electronics, Inc.          2447252   MILLENNIA 300                     1    1            1         2,542.00
- -----------------------------------------------------------------------------------------------------------------------------------
   2                                                   FREIGHT                          27    1            1           104.00
- -----------------------------------------------------------------------------------------------------------------------------------
   4       Micron Electronics, Inc.          2407092   ATCX, mini tower Intel P200       1    1            1         1,946.00
- -----------------------------------------------------------------------------------------------------------------------------------
   5       Thermlonics Laboratory, Inc.        43060   Various Laboratory parts          2    1            1           580.00
- -----------------------------------------------------------------------------------------------------------------------------------
   6                                                   FREIGHT                          27    1            1            41.25
- -----------------------------------------------------------------------------------------------------------------------------------
   7       Micron Electronics, Inc.          2407092   freight                          27    1            1           208.00
- -----------------------------------------------------------------------------------------------------------------------------------
   8       Thermlonics Laboratory, Inc.        43047   Various Laboratory parts          2    1            1         2,097.00
- -----------------------------------------------------------------------------------------------------------------------------------
   9                                                   FREIGHT                          27    1            1            83.75
- -----------------------------------------------------------------------------------------------------------------------------------
   11      Micron Electronics, Inc.          2414811   (2)Millennia 233, Millennia       1    3
                                                       266                                                 1         6,698.00
- -----------------------------------------------------------------------------------------------------------------------------------
   12                                                  Freight                          27    1            1           312.00
- -----------------------------------------------------------------------------------------------------------------------------------
   14      Thermlonics Laboratory, Inc.        43102   Various Laboratory parts          2    1            1           800.00
- -----------------------------------------------------------------------------------------------------------------------------------
   15                                                  FREIGHT                          27    1            1            48.50
- -----------------------------------------------------------------------------------------------------------------------------------
   16      Micron Electronics, Inc.          2487496   ATCX, mini tower Intel P200       1    1            1         2,419.00
- -----------------------------------------------------------------------------------------------------------------------------------
   17      Fisher Scientific                 2359650   Freezer                           6    1            1         5,816.85
- -----------------------------------------------------------------------------------------------------------------------------------
   18                                                  Refrigerator                      6    1            1         5,285.39
- -----------------------------------------------------------------------------------------------------------------------------------
   19      MDC                                318641   Valve Gate                        2    1            1         1,495.00
- -----------------------------------------------------------------------------------------------------------------------------------
   20                                                  Freight                          27    1            1            18.75
- -----------------------------------------------------------------------------------------------------------------------------------
   21      Beckman                           340834FT  Pipettor                         24    1            2        51,940.50
                                             01
- -----------------------------------------------------------------------------------------------------------------------------------
   22                                                  Freight and Insurance            27    1            2           421.82
- -----------------------------------------------------------------------------------------------------------------------------------
           Micron Electronics, Inc.          2487496   FREIGHT                          27    1            1           104.00
- -----------------------------------------------------------------------------------------------------------------------------------
   24
- -----------------------------------------------------------------------------------------------------------------------------------

<CAPTION>
                                         Schedule:  07
                                                   ----
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                                                        No entry required
                                                                     Tax Pd                        -------------------------------
 Item                                        Invoice   $ Pd By       Vndr?    Check     Transact    Net $ Due       Net $ Due
 No.       Vendor Name                       No.       Lesseee       (Y/N)    No.          Date        Lessee          Vendor
- ----------------------------------------------------------------------------------------------------------------------------------
<S>       <C>                                <C>       <C>           <C>      <C>       <C>        <C>              <C>
- ----------------------------------------------------------------------------------------------------------------------------------
   1       SRS                               75690-R         0.00        N                         $       0.00     $ 4,000.00
- ----------------------------------------------------------------------------------------------------------------------------------
   2       Micron Electronics, Inc.          2447252     2,542.00        Y    3055       6/5/98    $   2,542.00     $     0.00
- ----------------------------------------------------------------------------------------------------------------------------------
   2                                                       104.00        Y    3055       6/5/98    $     104.00     $     0.00
- ----------------------------------------------------------------------------------------------------------------------------------
   4       Micron Electronics, Inc.          2407092     1,946.00        Y    2913      5/12/98    $   1,946.00     $     0.00
- ----------------------------------------------------------------------------------------------------------------------------------
   5       Thermlonics Laboratory, Inc.        43060       580.00        Y    2921      5/14/98    $     580.00     $     0.00
- ----------------------------------------------------------------------------------------------------------------------------------
   6                                                        41.25        Y    2921      5/14/98    $      41.25     $     0.00
- ----------------------------------------------------------------------------------------------------------------------------------
   7       Micron Electronics, Inc.          2407092       208.00        Y    2913      5/12/98    $     208.00     $     0.00
- ----------------------------------------------------------------------------------------------------------------------------------
   8       Thermlonics Laboratory, Inc.        43047     2,097.00        Y    2923      5/14/98    $   2,097.00     $     0.00
- ----------------------------------------------------------------------------------------------------------------------------------
   9                                                        83.75        Y    2923      5/14/98    $      83.75     $     0.00
- ----------------------------------------------------------------------------------------------------------------------------------
   11      Micron Electronics, Inc.          2414811     6,698.00        Y    2953      5/21/98    $   6,698.00     $     0.00
- ----------------------------------------------------------------------------------------------------------------------------------
   12                                                      312.00        Y    2953      5/21/98    $     312.00     $     0.00
- ----------------------------------------------------------------------------------------------------------------------------------
   14      Thermlonics Laboratory, Inc.        43102       800.00        Y    3065       6/8/98    $     800.00     $     0.00
- ----------------------------------------------------------------------------------------------------------------------------------
   15                                                       48.50        Y    3065       6/8/98    $      48.50     $     0.00
- ----------------------------------------------------------------------------------------------------------------------------------
   16      Micron Electronics, Inc.          2487496     2,419.00        Y    3145      6/25/98    $   2,419.00     $     0.00
- ----------------------------------------------------------------------------------------------------------------------------------
   17      Fisher Scientific                 2359650                                               $       0.00     $ 5,816.85
- ----------------------------------------------------------------------------------------------------------------------------------
   18                                                                                              $       0.00     $ 5,285.39
- ----------------------------------------------------------------------------------------------------------------------------------
   19      MDC                                318641                                               $       0.00     $ 1,495.00
- ----------------------------------------------------------------------------------------------------------------------------------
   20                                                                                              $       0.00     $    18.75
- ----------------------------------------------------------------------------------------------------------------------------------
   21      Beckman                          340834FT                                               $       0.00     $51,940.50
                                            01
- ----------------------------------------------------------------------------------------------------------------------------------
   22                                                                                              $      50.00     $ 4,210.82
- ----------------------------------------------------------------------------------------------------------------------------------
           Micron Electronics, Inc.          2487496       104.00        Y    3145      6/25/98    $     104.00     $     0.00
- ----------------------------------------------------------------------------------------------------------------------------------
   24                                                                                              $       0.00     $     0.00
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                                                   -------------------------------
                                                                      TOTAL AMOUNT DUE TO LESSEE   $  17,983.50
                                                                                                   -------------------------------
                                                                                      TOTAL AMOUNT DUE TO VENDOR    $68,978.31
                                                                                                                    --------------
                                                                                                      TOTAL DRAW    $86,961.81
                                                                                                                    --------------
</TABLE>

Lessee Signature:  /s/ Stephen Zaniboni              Date:  7/10/98
                --------------------------                ----------

                                    Page 1
<PAGE>

                                   SCHEDULE
                                   --------


                                     Schedule No. 08 to Lease
                                     Dated as of February 5, 1998
                                     Between SEQUENOM, INC.
                                     and PHOENIX LEASING INCORPORATED


A.   Description and Purchase Price of Equipment
     -------------------------------------------

   Description of
     Equipment                                              Street Address
  (quantity, model                                          City, State and
 and serial number)  Purchase Price   Rent   Mfr./ Vendor       County
- --------------------------------------------------------------------------------

See Exhibit A attached hereto

Total:               $69,812.76    $1,898.91



B.   Terms
     -----

Base Term:         The Base Term shall commence on the date the Equipment is
                   received, installed and accepted for use, as shown on the
                   Acceptance Notice, and continue for 42 full months after the
                   "Rent Start Date."

Rent Start Date:   This shall be the first day of the month following the month
                   during which the Base Term commences; provided, however, that
                   if the Equipment is accepted on the first day of the month,
                   the Rent Start Date shall commence on the same day that the
                   Base Term commences.

Lease Rate Factor: (expressed as a percentage of Equipment's original Purchase
                   Price): 2.72%

Monthly Rental Payments in advance.

Base Rent Due:     Payable on the Rent Start Date shall be (1) the first and
                   last Rental Amount including any sales of use tax and (2) an
                   amount equal to 1/30th of the monthly rental amount using a
                   rate of 2.72% multiplied by the number of days, if any,
                   between (and including) the date the Base Term commences and
                   (but not including) the Rent Start Date, except that, if the
                   date of the Acceptance Notice related to this Schedule is
                   dated on or after the 20th of the month, this amount shall
                   not be included in the Base Rent Due.
<PAGE>

                                       Schedule No. 08 to Lease
                                       Dated as of February 5, 1998
                                       Between SEQUUNOM,INC
                                       and PHOENIX LEASING INCORPORATED

C.   Invoice Information: Lessee's and Lessor's addresses for invoice purposes
     --------------------
for the Equipment on the Schedule shall be as follows:

Lessee's Invoice Address:              Remit Monthly Rental Amount To:
- -------------------------              -------------------------------
SEQUENOM, INC.                         PHOENIX LEASING INCORPORATED
11555 Sorento Valley Road              P.O. Box 200432
San Diego, CA  92121                   Dallas, TX  75320-0432
Attention:  Mr. Steve Zaniboni, Vice President, Finance and Administration

D.  Casualty Values: See attachment hereto.
    ----------------

E.  Special Provisions: 1. Lessor's payment for Equipment hereunder is
    -------------------
conditioned on Lessor's satisfaction of the conditions set forth in Section 3 of
the Lease and 2. Sale Leaseback Addendum.

F.  End of Lease Position: (a) General. Lessee shall be required to choose a
    ----------------------     --------
final purchase or extension requirement ("End of Lease Position") at the
expiration of the Base Term (as defined in the Schedule) of the first Schedule
to the Lease. That choice shall be an election of Lessee's End of Lease
Position for all, but not less than all, of the Equipment under all Schedules to
the Lease. Lessee shall provide written notice of its election to Lessor at
least 90 days prior to the end of the Base Term of the first Schedule.

Any Equipment purchase election shall be a purchase of the Equipment, AS-IS,
WHERE-IS. Upon Lessor's receipt of the purchase price, Lessor shall issue to
Lessee an equipment bill of sale, transferring title to the Equipment to the
Lessee without any representation or warranty whatsoever. Lessee shall be
responsible for all applicable taxes in connection with any Equipment purchase.

In the event Lessee does not provide at least 90 days' prior written notice of
its election, Lessee shall be deemed to have elected Election No. 2.

At the expiration of the Base Term of the first Schedule Lessee shall be
required to elect to either:

Election No. 1: Purchase the Equipment for 25% of the Equipment's original
- ---------------
purchase price; or

Election No. 2: Extend the Schedule's Base Term for an additional 12 months
- ---------------
("Extended Term") for a monthly rate of 2.50% of the Equipment's original
purchase price.

At the expiration of the Extended Term, Lessee shall purchase the Equipment for
$1.00.

LESSOR AND LESSEE AGREE THAT THIS SCHEDULE SHALL CONSTITUTE A LEASE OF THE
EQUIPMENT DESCRIBED ABOVE, SUBJECT TO THE TERMS AND
<PAGE>

                                      Schedule No. 08 to Lease
                                      Dated as of February 5, 1998
                                      Between SEQUENOM, INC.
                                      and PHOENIX LEASING INCORPORATED

CONDITIONS OF THIS SCHEDULE AND OF THE MASTER EQUIPMENT LEASE DATED FEBRUARY 5,
1998 BETWEEN LESSEE AND LESSOR. THE TERMS AND CONDITIONS OF SUCH MASTER
EQUIPMENT LEASE ARE HEREBY INCORPORATED BY REFERENCE AND MADE A PART HEREOF TO
THE SAME EXTENT AS IF SUCH TERMS AND CONDITIONS WERE SET FORTH IN FULL HEREIN.

LESSOR:                                  LESSEE:

PHOENIX LEASING INCORPORATED             SEQUENOM, INC.

By:       /s/ Lynn Sanders               By:         /s/  Stephen Zaniboni
   --------------------------------         ----------------------------------
Name:     Lynn Sanders                   Name (Print):________________________
     ------------------------------
Title:    Contract Administrator         Title:_______________________________
      -----------------------------
Date:     September 1, 1998              Date:         September 1, 1998
     ------------------------------            -------------------------------

<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A

     Lessee:          SEQUENOM, INC.
                      ------------------
                      11555 SORRENTO VALLEY RD.
     Master Contract: 0135
                      ----

                                                                    Schedule: 08
                                                                              --

<TABLE>
<CAPTION>

- ---------------------------------------------------------------------------------------------------------------------

                                                                                                 L            Total
 Item                                                                   Eq            Serial     O         Invoic'd
  No     Vendor Name         Invoice No  Description of Item            Cd    Qty     Number     C    Net of Sls Tx
- ---------------------------------------------------------------------------------------------------------------------
 <S>     <C>                 <C>         <C>                            <C>   <C>     <C>       <C>   <C>
  1      Circa Information      83506    Printer, cable and user         2     1                 1        2,317.95
         Technologies, Inc.              manual
- ---------------------------------------------------------------------------------------------------------------------
  2                                      Delivery                       27     1                 1           29.61
- ----------------------------------------------------------------------------------------------------------------------
  3      NECX                  686251    128mb SDRam                     1     1                 1          178.95
- ----------------------------------------------------------------------------------------------------------------------
  4                                      Freight                        27     1                 1            5.95
- ----------------------------------------------------------------------------------------------------------------------
  5      NECX                  688379    Visual Studio 97 ent 95/nt     24     1                 1        1,299.95
- ----------------------------------------------------------------------------------------------------------------------
  6                                      Freight                        27     1                 1            3.95
- ----------------------------------------------------------------------------------------------------------------------
  7      Bertan                 33698    High voltage power supplies     2     1                 1        3,350.00
- ----------------------------------------------------------------------------------------------------------------------
  8                                      Freight                        27     1                 1           49.55
- ----------------------------------------------------------------------------------------------------------------------
  9      Bertan                 33705    High voltage power supplies     2     1                 1        1,675.00
- ----------------------------------------------------------------------------------------------------------------------
  10                                     Freight                        27     1                 1           31.35
- ----------------------------------------------------------------------------------------------------------------------
  11     Beckman Coulter     344406FT    Multimek '96 Pipettor           2     1                 1       40,920.00
                             D1
- ----------------------------------------------------------------------------------------------------------------------
  12                                     Multimek Pro Software          24     1                 1        4,650.00
- ----------------------------------------------------------------------------------------------------------------------
  13                                     Four Position Labware deck      2     1                 1          790.50
- ----------------------------------------------------------------------------------------------------------------------
  14                                     Disposable Tip wash system      2     1                 1        5,580.00
- ----------------------------------------------------------------------------------------------------------------------
  15     Inacom               7903046    IBM Think Pad                   1     1                 1        4,450.00
- ----------------------------------------------------------------------------------------------------------------------
  16                                     Freight                        27     1                 1           30.00
- ----------------------------------------------------------------------------------------------------------------------
  17     Micron Electronics,  2493404    Millenia 266 mini tower         1     1                 1        2,246.00
         Inc.                            computer
- ----------------------------------------------------------------------------------------------------------------------
  18                                     Freight                        27     1                 1          104.00
- ----------------------------------------------------------------------------------------------------------------------
  19     Micron Electronics,  2493426    Millenia 266 mini tower         1     1                 1        1,996.00
         Inc.                            computer
- ----------------------------------------------------------------------------------------------------------------------
  20                                     Freight                        27     1                 1          104.00
- ----------------------------------------------------------------------------------------------------------------------

<CAPTION>
- ----------------------------------------------------------------------------------------------------------------
                                                        Tax
                                                         Pd                             No entry required
                                                                                  ------------------------------
Item                                    $ Pd By   Vndr?  Chk    Transact      Net $ Due    Net $ Due       P
 No     Vendor Name         Invoice No  Leese     (Y/N)  No.        Date        Lessee        Vendor
- ----------------------------------------------------------------------------------------------------------------
<S>     <C>                 <C>         <C>       <C>    <C>    <C>           <C>          <C>             <C>
 1      Circa Information      83506               N                            $    0.00    $ 2,317.95
        Technologies, Inc.
- ----------------------------------------------------------------------------------------------------------------
 2                                                 N                            $    0.00    $    29.61
- ----------------------------------------------------------------------------------------------------------------
 3      NECX                  686251               N                            $    0.00    $   178.95
- ----------------------------------------------------------------------------------------------------------------
 4                                                 N                            $    0.00    $     5.95
- ----------------------------------------------------------------------------------------------------------------
 5      NECX                  688379               N                            $    0.00    $ 1,299.95
- ----------------------------------------------------------------------------------------------------------------
 6                                                 N                            $    0.00    $     3.95
- ----------------------------------------------------------------------------------------------------------------
 7      Bertan                 33698               N                            $    0.00    $ 3,350.00
- ----------------------------------------------------------------------------------------------------------------
 8                                                 N                            $    0.00    $    49.55
- ----------------------------------------------------------------------------------------------------------------
 9      Bertan                 33705               N                            $    0.00    $ 1,675.00
- ----------------------------------------------------------------------------------------------------------------
 10                                                N                            $    0.00    $    31.35
- ----------------------------------------------------------------------------------------------------------------
 11     Beckman Coulter     344406FT               N                            $    0.00    $40,920.00
                            D1
- ----------------------------------------------------------------------------------------------------------------
 12                                                N                            $    0.00    $ 4,650.00
- ----------------------------------------------------------------------------------------------------------------
 13                                                N                            $    0.00    $   790.50
- ----------------------------------------------------------------------------------------------------------------
 14                                                N                            $    0.00    $ 5,580.00
- ----------------------------------------------------------------------------------------------------------------
 15     Inacom               7903046    4,450.00   Y         3308    7/17/98    $4,450.00    $     0.00
- ----------------------------------------------------------------------------------------------------------------
 16                                        30.00   Y         3308    7/17/98    $   30.00    $     0.00
- ----------------------------------------------------------------------------------------------------------------
 17     Micron Electronics,  2493404    2,246.00   Y         3225    6/25/98    $2,246.00    $     0.00
        Inc.
- ----------------------------------------------------------------------------------------------------------------
 18                                       104.00   Y         3225    6/25/98    $  104.00    $     0.00
- ----------------------------------------------------------------------------------------------------------------
 19     Micron Electronics,  2493426    1,996.00   Y         3225    6/25/98    $1,996.00    $     0.00
        Inc.
- ----------------------------------------------------------------------------------------------------------------
 20                                       104.00   Y        32225    6/25/98    $  104.00    $     0.00
- ----------------------------------------------------------------------------------------------------------------

                                                                               ---------------------------------
                                                  TOTAL AMOUNT DUE TO LESSEEE   $8,930.00
                                                                               ---------------------------
                                                                TOTAL AMOUNT DUE TO VENDOR   $60,882.76
                                                                                            --------------
                                                                                TOTAL DRAW   $69,812.76
                                                                                            --------------
</TABLE>

             Lessee Signature:  __________________       Date: _________

<PAGE>

                                   SCHEDULE
                                   --------

                         Schedule No. 09 to Lease
                         Dated as of February 5, 1998
                         Between SEQUENOM, INC.
                         and PHOENIX LEASING INCORPORATED

A.   Description and Purchase Price of Equipment
     -------------------------------------------

<TABLE>
<CAPTION>

           Description of
              Equipment
          (quantity, model                     Purchase                               Mfr./                 Street Address
          and serial number                     Price              Rent               Vendor            City, State and County
          -----------------                     -----              ----               ------            ----------------------
     <S>                                   <C>                 <C>                    <C>               <C>
     See Exhibit A attached hereto.


         Total:                              $68,282.89          $1,857.29
</TABLE>

B.   Terms
     -----

Base Term:          The Base Term shall commence on the date the Equipment is
                    received, installed and accepted for use, as shown on the
                    Acceptance Notice, and continue for 42 full months after the
                    "Rent Start Date."

Rent Start Date:    This shall be the first day of the month following the month
                    during which the Base Term commences; provided, however,
                    that if the Equipment is accepted on the first day of the
                    month, the Rent Start Date shall commence on the same day
                    that the Base Term commences.

Lease Rate Factor (expressed as a percentage of Equipment's original Purchase
Price):  2.72%

Monthly Rental Payments in advance.

Base Rent Due:      Payable on the Rent Start Date shall be (1) the first and
                    last Rental Amount including any sales or use tax and (2) an
                    amount equal to 1/30th of the monthly rental amount using a
                    rate of 2.72% multiplied by the number of days, if any,
                    between (and including) the date the Base Term commences and
                    (but not including) the Rent Start Date, except that, if the
                    date of the Acceptance Notice related to this Schedule is
                    dated on or after the 20th of the month, this amount shall
                    not be included in the Base Rent Due.

C.   Invoice Information:  Lessee's and Lessor's addresses for invoice purposes
     -------------------
for the Equipment on the Schedule shall be as follows:


<TABLE>
<CAPTION>
Lessee's Invoice Address:                                        Remit Monthly Rental Amount To:
- ------------------------                                         ------------------------------
<S>                                                              <C>
SEQUENOM, INC.                                                   PHOENIX LEASING INCORPORATED
11555 Sorento Valley Road                                        P. O. Box 200432
San Diego, CA  92121                                             Dallas, TX  75320-0432
Attention:  Mr. Steve Zaniboni, Vice President, Finance and
Administration
</TABLE>
<PAGE>

                                               Schedule No. 09 to Lease
                                               Dated as of February 5, 1998
                                               Between SEQUENOM, INC.
                                               and PHOENIX LEASING INCORPORATED

D.   Casualty Values:  See attachment hereto.
     ---------------

E.   Special Provisions:  1.  Lessor's payment for Equipment hereunder is
     ------------------
conditioned on Lessor's satisfaction of the conditions set forth in Section 3 of
the Lease and 2. Sale Leaseback Addendum.

F.   End of Lease Position:  (a) General.  Lessee shall be required to choose a
     ---------------------       -------
final purchase or extension requirement ("End of Lease Position") at the
expiration of the Base Term (as defined in the Schedule) of the first Schedule
to the Lease.  That choice shall be an election of Lessee's End of Lease
Position for all, but not less than all, of the Equipment under all Schedules to
the Lease.  Lessee shall provide written notice of its election to Lessor at
least 90 days prior to the end of the Base Term of the first Schedule.

Any Equipment purchase election shall be a purchase of the Equipment, AS-IS,
WHERE-IS.  Upon Lessor's receipt of the purchase price, Lessor shall issue to
Lessee an equipment bill of sale, transferring title to the Equipment to the
Lessee without any representation or warranty whatsoever.  Lessee shall be
responsible for all applicable taxes in connection with any Equipment purchase.

In the event Lessee does not provide at least 90 days' prior written notice of
its election, Lessee shall be deemed to have elected Election No. 2.

At the expiration of the Base Term of the first Schedule Lessee shall be
required to elect to either:

Election No. 1.:  Purchase the Equipment for 25% of the Equipment's original
- -------- --- --
purchase price; or

Election No. 2.:  Extend the Schedule's Base Term for an additional 12 months
- -------- --- --
("Extended Term") for a monthly rate of 2.50% of the Equipment's original
purchase price.

At the expiration of the Extended Term, Lessee shall purchase the Equipment for
$1.00.

LESSOR AND LESSEE AGREE THAT THIS SCHEDULE SHALL CONSTITUTE A LEASE OF THE
EQUIPMENT DESCRIBED ABOVE, SUBJECT TO THE TERMS AND CONDITIONS OF THIS SCHEDULE
AND OF THE MASTER EQUIPMENT LEASE DATED FEBRUARY 5, 1998 BETWEEN LESSEE AND
LESSOR.  THE TERMS AND CONDITIONS OF SUCH MASTER EQUIPMENT LEASE ARE HEREBY
INCORPORATED BY REFERENCE AND MADE A PART HEREOF TO THE SAME EXTENT AS IF SUCH
TERMS AND CONDITIONS WERE SET FORTH IN FULL HEREIN.


LESSOR:                                     LESSEE:

PHOENIX LEASING INCORPORATED                SEQUENOM, INC.

By:   /s/  Lynn Sanders                     By:   /s/ Stephen Zaniboni
     ----------------------------------          -----------------------------
Name:     Lynn Sanders                      Name (Print):   Stephen Zaniboni
     ----------------------------------                    -------------------
Title:     Contract Administrator           Title:     SVP, Finance
     ----------------------------------             --------------------------
Date:   September 22, 1998                  Date:     September 22, 1998
     ----------------------------------           ----------------------------

<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A

     Lessee:  SEQUENOM INC
            ---------------------------
            11555 SORRENTO VALLEY ROAD

<TABLE>
<CAPTION>
Master Contract:  0135                                                                                    Schedule: 09
                 ----------------------                                                                            -------

- ---------------------------------------------------------------------------------------------------------------------------------
                                                                                           Total                Tax Pd
                  Invoice     Description of     Eq           Serial                  Invoic'd $      $ Pd By     Vndr?     Chk
Vendor Name       No.         Item               Cd     Qty   Number        Loc    Net of Sls Tx       Lessee     (Y/N)     No.
- ---------------------------------------------------------------------------------------------------------------------------------
<S>               <C>         <C>                <C>    <C>   <C>           <C>    <C>                <C>       <C>         <C>
MJ RESEARCH         50115     TETRAD UNIT         2     2     TD002873,      1         28,490.50                    N
                                                              TD002877
- ---------------------------------------------------------------------------------------------------------------------------------
                              ALPHA PWR BONNET    2     4     AL014745,      1         15,822.00                    N
                                                              AL014750,
                                                              AL017243,
                                                              AL017247
- ---------------------------------------------------------------------------------------------------------------------------------
                              ALPHA UNIT          2     4                    1          7,182.00                    N
- ---------------------------------------------------------------------------------------------------------------------------------
                              FREIGHT            27     1                    1            182.00                    N
- ---------------------------------------------------------------------------------------------------------------------------------
                    50164     ALPHA PWR BONNET    2     1     AL017805       1          3,955.50                    N
- ---------------------------------------------------------------------------------------------------------------------------------
                              FREIGHT            27     1                    1             11.00                    N
- ---------------------------------------------------------------------------------------------------------------------------------
BERTAN              33956     HVPS INST 313A      2     1     8129           1          1,499.00                    N
- ---------------------------------------------------------------------------------------------------------------------------------
NECX               699233     LASERJET            1     1     SJPFH048654    1          1,599.95                    N
- ---------------------------------------------------------------------------------------------------------------------------------
                              FREIGHT            27     1                    1             45.93                    N
- ---------------------------------------------------------------------------------------------------------------------------------
                   701394     OFFICE 97          24     2                    1          1,029.90                    N
- ---------------------------------------------------------------------------------------------------------------------------------
                              FREIGHT            27     1                    1              6.11                    N
- ---------------------------------------------------------------------------------------------------------------------------------
MICRON            4052440     MICRON COMPT        1     1     1289992        1          1,947.00      1,947.00      Y       3375
- ---------------------------------------------------------------------------------------------------------------------------------
                  2456639     MILLENNIA 266       1     1     1CFG4142910    1          2,021.00      2,021.00      Y       3088
- ---------------------------------------------------------------------------------------------------------------------------------
                              MILLENNIA 266       1     1     1CFG4142924    1          1,996.00      1,996.00      Y       3088
- ---------------------------------------------------------------------------------------------------------------------------------
                  2341470     MILLENNIA XKU       1     1     1CFG4014742    1          2,495.00      2,495.00      Y       2913
                              233
- ---------------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------------

<CAPTION>
- ---------------------------------------------------------------------------------
                                                            No entry required
                                                        -------------------------
                  Invoice              Transact         Net $ Due       Net $ Due
Vendor Name       No.                      Date            Lessee          Vendor
- ---------------------------------------------------------------------------------
<S>               <C>                  <C>              <C>            <C>
MJ RESEARCH         50115                               $    0.00      $28,490.50

- ---------------------------------------------------------------------------------
                                                        $    0.00


- ---------------------------------------------------------------------------------
                                                        $    0.00      $ 7,182.00
- ---------------------------------------------------------------------------------
                                                        $    0.00      $   182.00
- ---------------------------------------------------------------------------------
                    50164                               $    0.00      $ 3,955.50
- ---------------------------------------------------------------------------------
                                                        $    0.00      $    11.00
BERTAN              33956                               $    0.00      $ 1,499.00
- ---------------------------------------------------------------------------------
NECX               699233                               $    0.00      $ 1,599.95
- ---------------------------------------------------------------------------------
                                                        $    0.00      $    45.93
- ---------------------------------------------------------------------------------
                   701394                               $    0.00      $ 1,029.90
- ---------------------------------------------------------------------------------
                                                        $    0.00      $     6.11
- ---------------------------------------------------------------------------------
MICRON            4052440               7/28/98         $1,947.00      $     0.00
- ---------------------------------------------------------------------------------
                  2456639               6/10/98         $2,021.00      $     0.00
- ---------------------------------------------------------------------------------
                                        6/10/98         $1,996.00      $     0.00
- ---------------------------------------------------------------------------------
                  2341470               5/12/98         $2,495.00      $     0.00
- ---------------------------------------------------------------------------------
                                                        $    0.00      $     0.00
- ---------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------
                         TOTAL AMOUNT DUE TO LESSEE     $8,459.00
                                                        -------------------------
                                       TOTAL AMOUNT DUE TO VENDOR      $59,823.89
                                                                       ----------
                                                       TOTAL DRAW      $68,282.89
                                                                       ----------
</TABLE>


     Lessee Signature:  /s/ Stephen Zaniboni           Date:_  9/16/98
                      ---------------------------            --------------

                                  Page 1 of 1
<PAGE>

                                   SCHEDULE
                                   --------

                                             Schedule No. 10 to Lease
                                             Dated as of February 5, 1998
                                             Between SEQUENOM, INC.
                                             and PHOENIX LEASING INCORPORATED


A.   Description and Purchase Price of Equipment
     -------------------------------------------

<TABLE>
<CAPTION>
    Description of
      Equipment
  (quantity, model       Purchase                    Mfr./          Street Address
 and serial number)        Price         Rent        Vendor      City, State and County
- -------------------     -----------   ----------   ----------    ----------------------
<S>                     <C>           <C>          <C>           <C>
   See Exhibit A attached hereto.

Total:                  $149,756.37   $4,073.37
</TABLE>

B.  Terms
    -----

Base Term:               The Base Term shall commence on the date the Equipment
                         is received, installed and accepted for use, as shown
                         on the Acceptance Notice, and continue for 42 full
                         months after the "Rent Start Date."

Rent Start Date:         This shall be the first day of the month following the
                         month during which the Base Term commences; provided,
                         however, that if the Equipment is accepted on the first
                         day of the month, the Rent Start Date shall commence on
                         the same day that the Base Term commences.

Lease Rate Factor (expressed as a percentage of Equipment's original Purchase
Price): 2.72%

Monthly Rental Payments in advance.

Base Rent Due:           Payable on the Rent Start Date shall be (1) the first
                         and last Rental Amount including any sales or use tax
                         and (2) an amount equal to 1/30th of the monthly rental
                         amount using a rate of 2.72% multiplied by the number
                         of days, if any, between (and including) the date the
                         Base Term commences and (but not including) the Rent
                         Start Date, except that, if the date of the Acceptance
                         Notice related to this Schedule is dated on or after
                         the 20th of the month, this amount shall not be
                         included in the Base Rent Due.

C.   Invoice Information: Lessee's and Lessor's addresses for invoice purposes
     --------------------
for the Equipment on the Schedule shall be as follows:


Lessee's Invoice Address:                Remit Monthly Rental Amount To:
- -------------------------                -------------------------------
SEQUENOM, INC.                           PHOENIX LEASING INCORPORATED
11555 Sorento Valley Road                P.O. Box 200432
San Diego, CA 92121                      Dallas, TX 75320-0432
Attention:   Mr. Steve Zaniboni, Vice President, Finance and Administration
<PAGE>

                                             Schedule No. 10 to Lease
                                             Dated as of February 5, 1998
                                             Between SEQUENOM, INC.
                                             and PHOENIX LEASING INCORPORATED

D.   Casualty Values:  See attachment hereto.
     ----------------

E.   Special Provisions:  1. Lessor's payment for Equipment hereunder is
     ------------------
conditioned on Lessor's satisfaction of the conditions set forth in Section 3 of
the Lease and 2. Sale Leaseback Addendum.

F.   End of Lease Position: (a) General.  Lessee shall be required to choose a
     ---------------------      -------
final purchase or extension requirement ("End of Lease Position") at the
expiration of the Base Term (as defined in the Schedule) of the first Schedule
to the Lease. That choice shall be an election of Lessee's End of Lease Position
for all, but not less than all, of the Equipment under all Schedules to the
Lease. Lessee shall provide written notice of its election to Lessor at least 90
days prior to the end of the Base Term of the first Schedule.

Any Equipment purchase election shall be a purchase of the Equipment, AS-IS,
WHERE-IS.  Upon Lessor's receipt of the purchase price, Lessor shall issue to
Lessee an equipment bill of sale, transferring title to the Equipment to the
Lessee without any representation or warranty whatsoever.  Lessee shall be
responsible for all applicable taxes in connection with any Equipment purchase.

In the event Lessee does not provide at least 90 days' prior written notice of
its election, Lessee shall be deemed to have elected Election No. 2.

At the expiration of the Base Term of the first Schedule Lessee shall be
required to elect to either:

Election No. 1:  Purchase the Equipment for 25% of the Equipment's original
- --------------
purchase price; or

Election No. 2:  Extend the Schedule's Base Term for an additional 12 months
- --------------
("Extended Term") for a monthly rate of 2.50% of the Equipment's original
purchase price.

At the expiration of the Extended Term, Lessee shall purchase the Equipment for
$ 1.00.

LESSOR AND LESSEE AGREE THAT THIS SCHEDULE SHALL CONSTITUTE A LEASE OF THE
EQUIPMENT DESCRIBED ABOVE, SUBJECT TO THE TERMS AND CONDITIONS OF TIES SCHEDULE
AND OF THE MASTER EQUIPMENT LEASE DATED FEBRUARY 5,1998 BETWEEN LESSEE AND
LESSOR.  THE TERMS AND CONDITIONS OF SUCH MASTER EQUIPMENT LEASE ARE HEREBY
INCORPORATED BY REFERENCE AND MADE A PART HEREOF TO THE SAME EXTENT AS IF SUCH
TERMS AND CONDITIONS WERE SET FORTH IN FULL HEREIN.


LESSOR:                                   LESSEE:

PHOENIX LEASING INCORPORATED              SEQUENOM, INC.

By:   /s/ Lynn Sanders                    By:    /s/ Steven Zaniboni
      ---------------------------               ------------------------------
Name: Lynn Sanders                        Name (Print):    Steven Zaniboni
      ---------------------------                       ----------------------
Title: Contract Administrator             Title:    VP Finance
      ---------------------------               ------------------------------
Date:  October 23, 1998                   Date:    October 23, 1998
      ---------------------------               ------------------------------
<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A

          Lessee:  SEQUENOM, INC.
                   -------------------------
                   11555 SORRENTO VALLEY RD.

MASTER CONTRACT:  0135                                             Schedule:  10
                 ---------------------------                                 ---

<TABLE>
<CAPTION>
- ---------------------------------------------------------------------------------------------------------------------------------
                                                                                             L               Total
                                  Invoice    Description               Eq        Serial      o          Invoic'd $      $ Pd By
Vendor Name                       No.        of Item                   Cd  Qty   Number      c    Net of Sales Tax      Lessee
- ---------------------------------------------------------------------------------------------------------------------------------
<S>                              <C>         <C>                       <C> <C>   <C>        <C>   <C>                   <C>
Static Control Products               22871  aerostat pc                2    1   y386953     1            439.00           439.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1               1             34.02            34.02
- ---------------------------------------------------------------------------------------------------------------------------------
                                             freight                   27    1               1              4.86             4.86
- ---------------------------------------------------------------------------------------------------------------------------------
                                      22750  aerostat guardian          2    1   y402449     1            799.00           799.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1               1             61.92            61.92
- ---------------------------------------------------------------------------------------------------------------------------------
                                             freight                   27    1               1              8.63             8.63
- ---------------------------------------------------------------------------------------------------------------------------------
Asymtek                             30901.1  automive 303               1    1   sn8633      1         16,630.00        16,630.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             assy, 18xb counterbal.z    1    1   sn8634      1          2,315.00         2,315.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1               1            978.83           978.83
- ---------------------------------------------------------------------------------------------------------------------------------
Office Furniture                       3535  desk 30x60                 6    9               1          4,131.00         4,131.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             desk 36x72                 6    1               1            509.00           509.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             del & installation        27    1               1             50.00            50.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1               1            363.48           363.48
- ---------------------------------------------------------------------------------------------------------------------------------
                                       3596  mobile pedistal            6    3               1            525.00           525.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             del & installation        27    1               1             50.00            50.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1               1             44.56            44.56
- ---------------------------------------------------------------------------------------------------------------------------------
                                       3546  4 drwr file                6    1               1            449.00           449.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             del & installation        27    1               1             35.00            35.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1               1             37.51            37.51
- ---------------------------------------------------------------------------------------------------------------------------------
                                       3361  desk 30x60                 6    2               1            918.00           918.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             del & installation        27    1               1             50.00            50.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1               1             75.02            75.02
- ---------------------------------------------------------------------------------------------------------------------------------
                                       3390  desk 30x60                 6    1               1            459.00           459.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             del & installation        27    1               1             50.00            50.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1               1             39.45            39.45
- ---------------------------------------------------------------------------------------------------------------------------------
Waters                            263063052  service contract          26    1               1          4,391.00         4,391.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1               1             77.11            77.11
- ---------------------------------------------------------------------------------------------------------------------------------
Brannon                                2264  prints framed & mated     10    2               1            950.00           950.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             prints framed & mated     10    1               1            565.00           565.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1               1            117.41           117.41
- ---------------------------------------------------------------------------------------------------------------------------------
                                       2266  upgraded keyboard          1    1               1             75.25            75.25
- ---------------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1               1              5.83             5.83
- ---------------------------------------------------------------------------------------------------------------------------------
                                       2257  reception station, artwk   6    1               1          6,068.00         6,068.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1               1            470.27           470.27
- ---------------------------------------------------------------------------------------------------------------------------------
                                             del & installation        27    1               1            225.00           225.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                       2258  lounge chairs              6    3               1          3,435.00         3,435.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1               1            266.21           266.21
- ---------------------------------------------------------------------------------------------------------------------------------
                                             freight                   27    1               1            100.00           100.00
- ---------------------------------------------------------------------------------------------------------------------------------
                                       2259  task chair                 6    1               1            444.00           444.00
- ---------------------------------------------------------------------------------------------------------------------------------

<CAPTION>
- --------------------------------------------------------------------------------------------------------------------
                                                                                               No entry required
                                                    Tax Pd                                --------------------------
                                  Invoice           Vndr?       Check        Transact     Net $ Due      Net $ Due
Vendor Name                       No.               (Y/N)       No.          Date            Lessee         Vendor
- --------------------------------------------------------------------------------------------------------------------
<S>                               <C>               <C>         <C>          <C>          <C>            <C>
Static Control Products               22871           y          3399        7/30/98      $    439.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3399        7/30/98      $     34.02       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3399        7/30/98      $      4.86       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                      22750           y          3293        7/14/98      $    799.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3293        7/14/98      $     61.92       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3293        7/14/98      $      8.63       $0.00
- --------------------------------------------------------------------------------------------------------------------
Asymtek                             30901.1           y          3334        7/23/98      $ 16,630.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3334        7/23/98      $  2,315.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3334        7/23/98      $    978.83       $0.00
- --------------------------------------------------------------------------------------------------------------------
Office Furniture                       3535           y          3537         9/2/98      $  4,131.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3537         9/2/98      $    509.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3537         9/2/98      $     50.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3537         9/2/98      $    363.48       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                       3596           y          3670        9/18/98      $    525.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3670        9/18/98      $     50.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3670        9/18/98      $     44.56       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                       3546           y          3549         9/8/98      $    449.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3549         9/8/98      $     35.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3549         9/8/98      $     37.51       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                       3361           y          3353        7/23/98      $    918.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3353        7/23/98      $     50.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3353        7/23/98      $     75.02       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                       3390           y          3395        7/30/98      $    459.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3395        7/30/98      $     50.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3395        7/30/98      $     39.45       $0.00
- --------------------------------------------------------------------------------------------------------------------
Waters                            263063052           y          3408        8/11/98      $  4,391.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3408        8/11/98      $     77.11       $0.00
- --------------------------------------------------------------------------------------------------------------------
Brannon                                2264           y          3440        8/21/98      $    950.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3440        8/21/98      $    565.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3440        8/21/98      $    117.41       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                       2266           y          3548         9/8/98      $     75.25       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3548         9/8/98      $      5.83       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                       2257           y          3548         9/8/98      $  6,068.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3548         9/8/98      $    470.27       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3548         9/8/98      $    225.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                       2258           y          3410        8/11/98      $  3,435.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3410        8/11/98      $    266.21       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                                      y          3410        8/11/98      $    100.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
                                       2259           y          3410        8/11/98      $    444.00       $0.00
- --------------------------------------------------------------------------------------------------------------------
</TABLE>


                                  Page 1 of 3
<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A

<TABLE>
- ---------------------------------------------------------------------------------------------------------------------------
<S>                            <C>           <C>                       <C>   <C>                 <C>          <C>
                                             salestax                  29    1                   1             34.10
- ----------------------------------------------------------------------------------------------------------------------------
                               2261          24" occ tble               6    1                   1            687.00
- ----------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1                   1             53.24
- ----------------------------------------------------------------------------------------------------------------------------
                                             freight                   27    1                   1             50.00
- ----------------------------------------------------------------------------------------------------------------------------
                               2260          console table              6    1                   1            782.00
- ----------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1                   1             60.61
- ----------------------------------------------------------------------------------------------------------------------------
Micron                         4121719       micron comp ato            1    1    130717-0001    1          2,758.00
- ----------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1                   1            213.75
- ----------------------------------------------------------------------------------------------------------------------------
                                             freight                   27    1                   1            104.00
- ----------------------------------------------------------------------------------------------------------------------------
                               4086215       micron comp ato            1    1    1307116-0001   1          2,145.00
- ----------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1                   1            166.24
- ----------------------------------------------------------------------------------------------------------------------------
                                             freight                   27    1                   1            104.00
- ----------------------------------------------------------------------------------------------------------------------------
                               4075820       micron comp ato            1    1    1300793-0001   1          2,145.00
- ----------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1                   1            166.24
- ----------------------------------------------------------------------------------------------------------------------------
                                             freight                   27    1                   1            104.00
- ----------------------------------------------------------------------------------------------------------------------------
                               4075819       micron comp ato            1    1                   1          2,046.00
- ----------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1                   1            158.57
- ----------------------------------------------------------------------------------------------------------------------------
                                             freight                   27    1                   1            104.00
- ----------------------------------------------------------------------------------------------------------------------------
                               4080946       micron comp ato            1    1    1300722-0001   1          2,046.00
- ----------------------------------------------------------------------------------------------------------------------------
                                             salestax                  29    1                   1            158.57
- ----------------------------------------------------------------------------------------------------------------------------
                                             freight                   27    1                   1            104.00
- ----------------------------------------------------------------------------------------------------------------------------
necx                           0003n         superstack II switch       1    1                   1          1,499.95
- ----------------------------------------------------------------------------------------------------------------------------
                               722605        superstack II module       1    1                   1            614.95
- ----------------------------------------------------------------------------------------------------------------------------
                               722242        freight                   27    1                   1             46.60
- ----------------------------------------------------------------------------------------------------------------------------
                                             Superstack II              1    5                   1          5,999.75
- ----------------------------------------------------------------------------------------------------------------------------
                                             100 base fx                1    1                   1            469.95
- ----------------------------------------------------------------------------------------------------------------------------
                                             cable                      1    3                   1            182.85
- ----------------------------------------------------------------------------------------------------------------------------
Beckman Coulter                348319ft02    disp wash system           2    1    90056          1          5,580.00
- ----------------------------------------------------------------------------------------------------------------------------
                                             ins & freight             27    1                   1             38.02
- ----------------------------------------------------------------------------------------------------------------------------
                               348319ft01    Multimek 96 pipettor       2    1    304151aps      1         40,920.00
- ----------------------------------------------------------------------------------------------------------------------------
                                             multimek pro software     24    1                   1          4,650.00
- ----------------------------------------------------------------------------------------------------------------------------
                                             4 position labware deck    2    1                   1            790.50
- ----------------------------------------------------------------------------------------------------------------------------
                                             ins & freight             27    1                   1            329.08
- ----------------------------------------------------------------------------------------------------------------------------
Inacom                         8017475       keyboard, mouse assec      1    1                   1            379.00
- ----------------------------------------------------------------------------------------------------------------------------
                                             17" monitor                1    1                   1            461.00
- ----------------------------------------------------------------------------------------------------------------------------
                                             cd rom                     1    1                   1            374.00
- ----------------------------------------------------------------------------------------------------------------------------
                                             ibm li-ion batt            1    1                   1            216.00
- ----------------------------------------------------------------------------------------------------------------------------
                                             shipping                  27    1                   1             11.60
- ----------------------------------------------------------------------------------------------------------------------------
                               8008480       ibm tp 600                 1    1                   1          2,339.00
- ----------------------------------------------------------------------------------------------------------------------------
                                             shipping                  27    1                   1             18.30
- ----------------------------------------------------------------------------------------------------------------------------
Danielson                      28383         universal pwr supply       2    1                   1          1,950.00
- ----------------------------------------------------------------------------------------------------------------------------
                                             photron u shape module     2    1                   1          1,630.00
- ----------------------------------------------------------------------------------------------------------------------------
                                             shipping                  27    1                   1            102.45
- ----------------------------------------------------------------------------------------------------------------------------
computer protection tech       4713-cpt      battery fe2 & casters      2    1                   1          2,505.00
- ----------------------------------------------------------------------------------------------------------------------------
                                             shipping                  27    1                   1            369.89
- ----------------------------------------------------------------------------------------------------------------------------
fischer scientific             3859485       8' vol super rem           2    1                   1          3,972.75
- ----------------------------------------------------------------------------------------------------------------------------
                                             storage unit               2    1                   1          2,180.25
- ----------------------------------------------------------------------------------------------------------------------------
                                             acid storage               2    1                   1            886.50
- ----------------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
<S>                            <C>           <C>                       <C>   <C>                 <C>          <C>
                                               34.10       y               3410     8/11/98       $     34.10  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                               2261           687.00       y               3410     8/11/98       $    687.00  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                                               53.24       y               3410     8/11/98       $     53.24  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                                               50.00       y               3410     8/11/98       $     50.00  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                               2260           782.00       y               3410     8/11/98       $    782.00  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                                               60.61       y               3410     8/11/98       $     60.61  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
Micron                         4121719      2,758.00       y               3654     9/18/98       $  2,758.00  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                                              213.75       y               3654     9/18/98       $    213.75  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                                              104.00       y               3654     9/18/98       $    104.00  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                               4086215      2,145.00       y               3584     9/11/98       $  2,145.00  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                                              166.24       y               3584     9/11/98       $    166.24  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                                              104.00       y               3584     9/11/98       $    104.00  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                               4075820      2,145.00       y               3469     8/24/98       $  2,145.00  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                                              166.24       y               3469     8/24/98       $    166.24  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                                              104.00       y               3469     8/24/98       $    104.00  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                               4075819      2,046.00       y               3469     8/24/98       $  2,046.00  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                                              158.57       y               3469     8/24/98       $    158.57  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                                              104.00       y               3469     8/24/98       $    104.00  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                               4080946      2,046.00       y               3531     8/31/98       $  2,046.00  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                                              158.57       y               3531     8/31/98       $    158.57  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                                              104.00       y               3531     8/31/98       $    104.00  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
necx                           0003n        1,499.95       n               3527     8/26/98       $  1,499.95  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                               722605         614.95       n               3527     8/26/98       $    614.95  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                               722242          46.60       n               3527     8/26/98       $     46.60  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                                            5,999.75       n               3527     8/26/98       $  5,999.75  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                                              469.95       n               3527     8/26/98       $    469.95  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
                                              182.85       n               3527     8/26/98       $    182.85  $     0.00
- ---------------------------------------------------------------------------------------------------------------------------
Beckman Coulter                348319ft02                                                         $      0.00  $ 5,580.00
- ---------------------------------------------------------------------------------------------------------------------------
                                                                                                  $      0.00  $    38.02
- ---------------------------------------------------------------------------------------------------------------------------
                               348319ft01                                                         $      0.00  $40,920.00
- ---------------------------------------------------------------------------------------------------------------------------
                                                                                                  $      0.00  $ 4,650.00
- ---------------------------------------------------------------------------------------------------------------------------
                                                                                                  $      0.00  $   790.50
- ---------------------------------------------------------------------------------------------------------------------------
                                                                                                  $      0.00  $   329.08
- ---------------------------------------------------------------------------------------------------------------------------
Inacom                         8017475                                                            $      0.00  $   379.00
- ---------------------------------------------------------------------------------------------------------------------------
                                                                                                  $      0.00  $   461.00
- ---------------------------------------------------------------------------------------------------------------------------
                                                                                                  $      0.00  $   374.00
- ---------------------------------------------------------------------------------------------------------------------------
                                                                                                  $      0.00  $   216.00
- ---------------------------------------------------------------------------------------------------------------------------
                                                                                                  $      0.00  $    11.60
- ---------------------------------------------------------------------------------------------------------------------------
                               8008480                                                            $      0.00  $ 2,339.00
- ---------------------------------------------------------------------------------------------------------------------------
                                                                                                  $      0.00  $    18.30
- ---------------------------------------------------------------------------------------------------------------------------
Danielson                      28383                                                              $      0.00  $ 1,950.00
- ---------------------------------------------------------------------------------------------------------------------------
                                                                                                  $      0.00  $ 1,630.00
- ---------------------------------------------------------------------------------------------------------------------------
                                                                                                  $      0.00  $   102.45
- ---------------------------------------------------------------------------------------------------------------------------
computer protection tech       4713-cpt                                                           $      0.00  $ 2,505.00
- ---------------------------------------------------------------------------------------------------------------------------
                                                                                                  $      0.00  $   369.89
- ---------------------------------------------------------------------------------------------------------------------------
fischer scientific             3859485                                                            $      0.00  $ 3,972.75
- ---------------------------------------------------------------------------------------------------------------------------
                                                                                                  $      0.00  $ 2,180.25
- ---------------------------------------------------------------------------------------------------------------------------
                                                                                                  $      0.00  $   886.50
- ---------------------------------------------------------------------------------------------------------------------------
</TABLE>

                           Page 2 of 3

<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A

<TABLE>
<S>                              <C>         <C>                       <C>  <C>  <C>            <C>         <C>        <C>
- ------------------------------------------------------------------------------------------------------------------------------------
                                             base vent                  2    1                   1             23.25
- ------------------------------------------------------------------------------------------------------------------------------------
                                             epxy resin hood            2    1                   1            672.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                             epxy cupsink               2    2                   1             73.50
- ------------------------------------------------------------------------------------------------------------------------------------
                                             remote control             2    2                   1            169.50
- ------------------------------------------------------------------------------------------------------------------------------------
                                    4066544  bal table                  2    1                   1            779.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                    3903757  glassware washer           2    1                   1          4,090.65
- ------------------------------------------------------------------------------------------------------------------------------------
                                    3974181  remote dispenser           2    1                   1            401.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                             epure 3module sys          2    1                   1          1,850.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                    3558226  remote control gas         2    2                   1            130.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                    3628327  lb 4.5 ml pp               2    1                   1            192.91
- ------------------------------------------------------------------------------------------------------------------------------------
                                    0827169  jerrican flour hdpe        2    2                   1            343.18
- ------------------------------------------------------------------------------------------------------------------------------------
                                    1375068  tape                       2    4                   1             84.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                             guanidine thiocyanate      2    1                   1             59.42
- ------------------------------------------------------------------------------------------------------------------------------------
                                     188788  well strip ind             2    1                   1            176.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                    1973610  thrm bi3                   2    1                   1             37.43
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2015207  tip ylw bulk               2    1                   1            235.42
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2039210  utility cart               2    1                   1            150.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                             glass beads                2    1                   1             13.97
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2086763  epp carousel stand         2    5                   1            495.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                             wash btl                   2    3                   1             45.33
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2107879  prtbl strd bal             2    1                   1             74.25
- ------------------------------------------------------------------------------------------------------------------------------------
                                             adapter                    2    1                   1             13.13
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2447487  tank closed dome           2    1                   1            115.20
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2789542  shoe cvr nstyvek           2    1                   1             50.32
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2812009  hzd signs                  2    2                   1              7.40
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2834922  membrane dialflo           2    1                   1            170.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2879077  temp reg                   2    1                   1             21.50
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2926441  disp can disconn           2    1                   1            291.38
- ------------------------------------------------------------------------------------------------------------------------------------
                                    3198783  support stand              2    1                   1             36.56
- ------------------------------------------------------------------------------------------------------------------------------------

<CAPTION>
<S>                                 <C>      <C>                    <C>       <C>    <C>     <C>        <C>              <C>
- ------------------------------------------------------------------------------------------------------------------------------------
                                             base vent                                                   $      0.00      $    23.25
- ------------------------------------------------------------------------------------------------------------------------------------
                                             epxy resin hood                                             $      0.00      $   672.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                             epxy cupsink                                                $      0.00      $    73.50
- ------------------------------------------------------------------------------------------------------------------------------------
                                             remote control                                              $      0.00      $   169.50
- ------------------------------------------------------------------------------------------------------------------------------------
                                    4066544  bal table                                                   $      0.00      $   779.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                    3903757  glassware washer                                            $      0.00      $ 4,090.65
- ------------------------------------------------------------------------------------------------------------------------------------
                                    3974181  remote dispenser                                            $      0.00      $   401.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                             epure 3module sys                                           $      0.00      $ 1,850.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                    3558226  remote control gas                                          $      0.00      $   130.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                    3628327  lb 4.5 ml pp                                                $      0.00      $   192.91
- ------------------------------------------------------------------------------------------------------------------------------------
                                    0827169  jerrican flour hdpe                                         $      0.00      $   343.18
- ------------------------------------------------------------------------------------------------------------------------------------
                                    1375068  tape                                                        $      0.00      $    84.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                             guanidine thiocyanate                                       $      0.00      $    59.42
- ------------------------------------------------------------------------------------------------------------------------------------
                                     188788  well strip ind                                              $      0.00      $   176.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                    1973610  thrm bi3                                                    $      0.00      $    37.43
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2015207  tip ylw bulk                                                $      0.00      $   235.42
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2039210  utility cart                                                $      0.00      $   150.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                             glass beads                                                 $      0.00      $    13.97
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2086763  epp carousel stand                                          $      0.00      $   495.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                             wash btl                                                    $      0.00      $    45.33
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2107879  prtbl strd bal                                              $      0.00      $    74.25
- ------------------------------------------------------------------------------------------------------------------------------------
                                             adapter                                                     $      0.00      $    13.13
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2447487  tank closed dome                                            $      0.00      $   115.20
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2789542  shoe cvr nstyvek                                            $      0.00      $    50.32
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2812009  hzd signs                                                   $      0.00      $     7.40
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2834922  membrane dialflo                                            $      0.00      $   170.00
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2879077  temp reg                                                    $      0.00      $    21.50
- ------------------------------------------------------------------------------------------------------------------------------------
                                    2926441  disp can disconn                                            $      0.00      $   291.38
- ------------------------------------------------------------------------------------------------------------------------------------
                                    3198783  support stand                                               $      0.00      $    36.56
- ------------------------------------------------------------------------------------------------------------------------------------
                                                                                                         $      0.00      $     0.00
- ------------------------------------------------------------------------------------------------------------------------------------

                                                                                                   ---------------------------------
                                                                                                         $      0.00      $     0.00
                                                                                                   ---------------------------------
TOTAL AMOUNT DUE TO LESSEE                                                                               $ 69 251.73
                                                                                                   ---------------------------------
                     TOTAL AMOUNT DUE TO VENDOR                                                                          $ 80 504.64
                                                                                                                    ----------------
                                     TOTAL DRAW                                                                          $149 756.37
                                                                                                                    ----------------
</TABLE>

Lessee Signature:  /s/ Steve Zaniboni                           Date:  10/20/98
                 -----------------------------                       -----------

                                  Page 3 of 3
<PAGE>

                        ADDITIONAL COMMITMENT SCHEDULE
                        ------------------------------

                                Schedule (Additional Commitment) No. 11 to Lease
                                Dated as of February 5, 1998
                                Between SEQUENOM, INC.
                                and PHOENIX LEASING INCORPORATED

A.   Description and Purchase Price of Equipment
     -------------------------------------------

<TABLE>
<CAPTION>
    Description of
      Equipment
  (quantity, model      Purchase                    Mfr./       Street Address City,
  and serial number)     Price        Rent        Vendor         State and County
 --------------------  ----------    ------      ---------     ----------------------
<S>                    <C>           <C>         <C>           <C>
  See Exhibit A attached hereto.

  Total:               $130,902.76   $3,560.56
</TABLE>

B.   Terms
     -----

Base Term:            The Base Term shall commence on the date the Equipment is
                      received, installed and accepted for use, as shown on the
                      Acceptance Notice, and continue for 42 full months after
                      the "Rent Start Date."

Rent Start Date:      This shall be the first day of the month following the
                      month during which the Base Term commences; provided,
                      however, that if the Equipment is accepted on the first
                      day of the month, the Rent Start Date shall commence on
                      the same day that the Base Term commences.

Lease Rate Factor (expressed as a percentage of Equipment's original Purchase
Price): 2.72%

Monthly Rental Payments in advance.

Base Rent Due:        Payable on the Rent Start Date shall be (1) the first and
                      last Rental Amount including any sales or use tax and (2)
                      an amount equal to 1/30th of the monthly rental amount
                      using a rate of 2.72% multiplied by the number of days, if
                      any, between (and including) the date the Base Term
                      commences and (but not including) the Rent Start Date,
                      except that, if the date of the Acceptance Notice related
                      to this Schedule is dated on or after the 20th of the
                      month, this amount shall not be included in the Base Rent
                      Due.

C.   Invoice Information:  Lessee's and Lessor's addresses for invoice purposes
     -------------------
for the Equipment on the schedule be as follows:

<TABLE>
<CAPTION>
Lessee's Invoice Address:                               Remit Monthly Rental Amount To:
- -------------------------                               -------------------------------
<S>                                                     <C>
SEQUENOM, INC.                                          PHOENIX LEASING INCORPORATED
11555 Sorrento Valley Road                              P.O. Box 200432
San Diego, CA 92121                                     Dallas, TX 75320-0432
Attention: Mr. Steve Zaniboni, Vice President, Finance and Administration
</TABLE>
<PAGE>

                               Schedule (Additional Commitment) No. 11 to Lease
                               Dated as of February 5, 1998
                               Between SEQUENOM INC.
                               and PHOENIX LEASING INCORPORATED

D.   Casualty Values: See attachment hereto.
     ---------------

E.   Special Provisions: 1. Lessor's payment for Equipment hereunder is
     ------------------
conditioned on Lessor's satisfaction of the conditions set forth in Section 3 of
the Lease and 2. Sale Leaseback Addendum.

F.   End of Lease Position:(a) General.  Lessee shall be required to choose a
     ---------------------     -------
     final purchase or extension requirement ("End of Lease Position") at the
     expiration of the Base Term (as defined in the Schedule) of the First
     Schedule to the Lease.  That choice shall be an election of Lessee's End of
     Lease Position for all, but not less than all of the Equipment under all
     Schedules to the Lease.  Lessee shall provide written notice of its
     election to Lessor at least 90 days prior to the end of the Base Term of
     the first Schedule.

Any Equipment purchase election shall be a purchase of the Equipment, AS-IS,
WHERE-IS.  Upon Lessor's receipt of the purchase price, Lessor shall issue to
Lessee an equipment bill of sale, transferring title to the Equipment to the
Lessee without any representation or warranty whatsoever.  Lessee shall be
responsible for all applicable taxes in connection with any Equipment Purchase.

In the event Lessee does not provide at least 90 days' prior written notice of
its election, Lessee shall be deemed to have elected Election No. 2.

At the expiration of the Base Term of the first Schedule Lessee shall be
required to elect to either:

Election No. 1: Purchase the Equipment for 25% of the Equipment's original
- --------------
purchase price; or

Election No. 2: Extend the Schedule's Base Term for an additional 12 months
- --------------
("Extended Term") for a monthly rate of 2.50% of the Equipment's original
purchase price.

At the expiration of the Extended Term, Lessee shall purchase the Equipment for
$1.00.

LESSOR AND LESSEE AGREE THAT THIS SCHEDULE SHALL CONSTITUTE A LEASE OF THE
EQUIPMENT DESCRIBED ABOVE, SUBJECT TO THE TERMS AND CONDITIONS OF THIS SCHEDULE
AND OF THE MASTER EQUIPMENT LEASE DATED FEBRUARY 5, 1998 BETWEEN LESSEE AND
LESSOR.  THE TERMS AND CONDITIONS OF SUCH MASTER EQUIPMENT LEASE ARE HEREBY
INCORPORATED BY REFERENCE AND MADE A PART HEREOF TO THE SAME EXTENT AS IF SUCH
TERMS AND CONDITIONS WERE SET FORTH IN FULL HEREIN.

LESSOR:                                  LESSEE:

PHOENIX LEASING INCORPORATED             SEQUENOM, INC.

By:    /s/ David Haward                  By:     /s/ Stephen Zaniboni
   ---------------------------------        ------------------------------------
Name:  David Haward                      Name (Print): Stephen Zaniboni
     -------------------------------         -----------------------------------
Title: Contract Administrator            Title:  SVP FINANCE
      ------------------------------           ---------------------------------
Date:_______________________________     Date:__________________________________
<PAGE>

                               ACCEPTANCE NOTICE

                    SCHEDULE (ADDITIONAL COMMITMENT) NO. 11

Reference is made to the Master Equipment Lease dated as of February 5, 1998
between PHOENIX LEASING INCORPORATED as Lessor and SEQUENOM, INC. as Lessee (the
"Lease").

Lessee confirms that the following Equipment has been received, installed and is
ready for use by Lessee.  The Equipment is satisfactory  in all respects for the
purposes of this Lease as of the date Lessee executes this Notice below.

<TABLE>
<CAPTION>
       Description of
    Equipment (quantity,       Purchase                  Mfr./    Street Address City,
  model and serial number)       Price       Rent      Vendor      State and County
 --------------------------   ----------    ------    ---------  ----------------------
 <S>                          <C>           <C>       <C>        <C>
 See Exhibit A attached hereto.


 Total:                       $130,902.76  $3,560.56
</TABLE>

THE LEASE MAY NOT BE CHANGED, ALTERED OR MODIFIED EXCEPT BY AN INSTRUMENT IN
WRITING SIGNED BY AN OFFICER OF LESSOR AND A DULY AUTHORIZED REPRESENTATIVE OF
LESSEE.

IN WITNESS WHEREOF, Lessee has executed this Acceptance Notice as of January 1,
1999.

                              SEQUENOM, INC.

                              By:  /s/ Stephen Zaniboni
                                 -------------------------------------

                              Name:    Stephen Zaniboni
                                   -----------------------------------

                              Title:   SVP Finance
                                    ----------------------------------
<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A


     Lessee: SEQUENOM, INC.
             --------------
             11555 SORRENTO VALLEY ROAD
             SAN DIEGO, CA 94121

<TABLE>
<CAPTION>
Master Contract:  0135                                                                                    Schedule:   11
                 ------                                                                                             ------

- ---------------------------------------------------------------------------------------------------------------------------------
                                                                                                       Total
 Item                    Invoice     Description            Eq              Serial                   Invoic'd $          $ Pd By
 No      Vendor Name     No.         of Item                Cd     Qty      Number        LOC    Net of Sls Tax           Lessee
- ---------------------------------------------------------------------------------------------------------------------------------
<S>      <C>             <C>         <C>                    <C>    <C>    <C>             <C>    <C>                    <C>
- ---------------------------------------------------------------------------------------------------------------------------------
 1       Micron          4184588     Millennia 400 Max       1       1                     1           2,573.00         2,573.00
- ---------------------------------------------------------------------------------------------------------------------------------
 2                       4134949     micron Computer ATO     1       1                     1           2,563.00         2,563.00
- ---------------------------------------------------------------------------------------------------------------------------------
 3                       4161499     Millennia 333           1       1                     1           1,826.00         1,826.00
- ---------------------------------------------------------------------------------------------------------------------------------
 4       MJ Research       52848     DNA Chassis             2       1    EN008435         1           4,945.50
- ---------------------------------------------------------------------------------------------------------------------------------
 5                                   Alpha Unit              2       2    al019740,
                                                                          al017681         1           3,590.00
- ---------------------------------------------------------------------------------------------------------------------------------
 6                                   freight                27       1                     1              51.00
- ---------------------------------------------------------------------------------------------------------------------------------
 7       Inacom          8173337     IBM                     1       1     78bcy16         1           3,065.00
- ---------------------------------------------------------------------------------------------------------------------------------
 8                                   keyboard, adapter etc   1       1                                   531.00
- ---------------------------------------------------------------------------------------------------------------------------------
 9                                   freight                27       1                     1               8.26
- ---------------------------------------------------------------------------------------------------------------------------------
 10      biosystems     90182528     ABI PRISM               2       1    10000750         1         102,150.00
- ---------------------------------------------------------------------------------------------------------------------------------
 11                                  SOFTWARE               24       1                     1           5,500.00
- ---------------------------------------------------------------------------------------------------------------------------------
 12                                  KIT 48CM                2       1                     1           2,000.00
- ---------------------------------------------------------------------------------------------------------------------------------
 13                                  KIT36CM                 2       1                     1           1,300.00
- ---------------------------------------------------------------------------------------------------------------------------------
 14                                  KIT 12CM                1       1                     1             800.00
- ---------------------------------------------------------------------------------------------------------------------------------
 #REF!
- ---------------------------------------------------------------------------------------------------------------------------------

<CAPTION>
- ---------------------------------------------------------------------------------------------
                                                                       No entry required
                                                                  ---------------------------
                           Tax Pd
 Item                       Vndr?     Chk        Transact         Net $ Due       Net $ Due
 No      Vendor Name        (Y/N)     No.          Date            Lessee           Vendor
- ---------------------------------------------------------------------------------------------
<S>      <C>               <C>        <C>        <C>              <C>             <C>
 1       Micron               N       3851       10/19/98         $2,573.00       $      0.00
- ---------------------------------------------------------------------------------------------
 2                            N       3693        9/22/98         $2,563.00       $      0.00
- ---------------------------------------------------------------------------------------------
 3                            N       3786       10/13/98         $1,826.00       $      0.00
- ---------------------------------------------------------------------------------------------
 4       MJ Research                                              $    0.00       $  4,945.50
- ---------------------------------------------------------------------------------------------
 5                                                                $    0.00       $  3,590.00

- ---------------------------------------------------------------------------------------------
 6                                                                $    0.00       $     51.00
- ---------------------------------------------------------------------------------------------
 7       Inacom                                                   $    0.00       $  3,065.00
- ---------------------------------------------------------------------------------------------
 8                                                                $    0.00       $    531.00
- ---------------------------------------------------------------------------------------------
 9                                                                $    0.00       $      8.26
- ---------------------------------------------------------------------------------------------
 10      biosystems                                               $    0.00       $102.150.00
- ---------------------------------------------------------------------------------------------
 11                                                               $    0.00       $  5,500.00
- ---------------------------------------------------------------------------------------------
 12                                                               $    0.00       $  2,000.00
- ---------------------------------------------------------------------------------------------
 13                                                               $    0.00       $  1,300.00
- ---------------------------------------------------------------------------------------------
 14                                                               $    0.00       $    800.00
- ---------------------------------------------------------------------------------------------
 #REF!
- ---------------------------------------------------------------------------------------------
                                      TOTAL AMOUNT DUE TO LESSEE  $6,962.00
                                                                  ---------------------------
                                                 TOTAL AMOUNT DUE TO VENDOR       $123,940.76
                                                                                  -----------
                                                                 TOTAL DRAW       $130,902.76
                                                                                  -----------
</TABLE>

Lessee Signature: /s/ Stephen Zaniboni            Date:  12/14/98
                  -----------------------------          --------

                                  Page 1 of 1
                   Property of Phoenix Leasing Incorporated
<PAGE>

                        ADDITIONAL COMMITMENT SCHEDULE
                        ------------------------------

                                Schedule (Additional Commitment) No. 12 to Lease
                                Dated as of February 5, 1998
                                Between SEQUENOM, INC.
                                and PHOENIX LEASING INCORPORATED

A.  Description and Purchase Price of Equipment
    -------------------------------------------

<TABLE>
<CAPTION>
Description of
   Equipment                                                         Street Address
(quantity, model                                                     City, State and
and serial number)      Purchase Price       Rent     Mfr./ Vendor       County
- ---------------------------------------------------------------------------------------
<S>                     <C>              <C>          <C>            <C>
See Exhibit A attached hereto
Total:                   $179,913.85     $4,893.66
</TABLE>

B.  Terms
    -----

Base Term:         The Base Term shall commence on the date the Equipment is
                   received, installed and accepted for use, as shown on the
                   Acceptance Notice, and continue for 42 full months after the
                   "Rent Start Date."

Rent Start Date:   This shall be the first day of the month following the month
                   during which the Base Term commences; provided, however, that
                   if the Equipment is accepted on the first day of the month,
                   the Rent Start Date shall commence on the same day that the
                   Base Term commences.

Lease Rate Factor: (expressed as a percentage of Equipment's original Purchase
                   Price): 2.72%

Base Rent Due:     Payable on the Rent Start Date shall be (1) the first and
                   last Rental Amount including any sales of use tax and (2) an
                   amount equal to 1/30th of the monthly rental amount using a
                   rate of 2.72% multiplied by the number of days, if any,
                   between (and including) the date the Base Term commences and
                   (but not including) the Rent Start Date, except that, if the
                   date of the Acceptance Notice related to this Schedule is
                   dated on or after the 20th of the month, this amount shall
                   not be included in the Base Rent Due.
<PAGE>

                                 Schedule (Additional Commitment) No.12 to Lease
                                 Dated as of February 5, 1998
                                 Beteen SEQUENOM, INC.
                                 and PHOENIX LEASING INCORPORATED

C.  Invoice Information:  Lessee's and Lessor's addresses for invoice purposes
    --------------------
for the Equipment on the Schedule shall be as follows:

Lessee's Invoice Address:    Remit Monthly Rental Amount To:
- -------------------------    -------------------------------
SEQUENOM, INC.               PHOENIX LEASING INCORPORATED
11555 Sorento Valley Road    P.O. Box 200432
San Diego, CA  92121         Dallas, TX  75320-0432
Attention:  Mr. Steve Zaniboni, Vice President, Finance and Administration

D.  Casualty Values:  See attachment hereto.
    ----------------

E.  Special Provisions:  1.  Lessor's payment for Equipment hereunder is
    -------------------
conditioned on Lessor's satisfaction of the conditions set forth in Section 3 of
the Lease and 2.  Sale Leaseback Addendum.

F.  End of Lease Position: (a) General.  Lessee shall be required to choose a
    ----------------------     --------
final purchase or extension requirement ("End of Lease Position") at the
expiration of the Base Term (as defined in the Schedule) of the first Schedule
to the Lease.  That choice shall be an election of Lessee's End of Lease
Position for all, but not less than all, of the Equipment under all Schedules to
the Lease.  Lessee shall provide written notice of its election to Lessor at
least 90 days prior to the end of the Base Term of the first Schedule.

Any Equipment purchase election shall be a purchase of the Equipment, AS-IS,
WHERE-IS.  Upon Lessor's receipt of the purchase price, Lessor shall issue to
Lessee an equipment bill of sale, transferring title to the Equipment to the
Lessee without any representation or warranty whatsoever.  Lessee shall be
responsible for all applicable taxes in connection with any Equipment purchase.

In the event Lessee does not provide at least 90 days' prior written notice of
its election, Lessee shall be deemed to have elected Election No. 2.

At the expiration of the Base Term of the first Schedule Lessee shall be
required to elect to either:

Election No. 1:  Purchase the Equipment for 25% of the Equipment's original
- ---------------
purchase price; or

Election No. 2:  Extend the Schedule's Base Term for an additional 12 months
- ---------------
("Extended Term") for a monthly rate of 2.50% of the Equipment's original
purchase price.

At the expiration of the Extended Term, Lessee shall purchase the Equipment for
$1.00.

LESSOR AND LESSEE AGREE THAT THIS SCHEDULE SHALL CONSTITUTE A LEASE OF THE
EQUIPMENT DESCRIBED ABOVE, SUBJECT TO THE TERMS AND
<PAGE>

                                Schedule (Additional Commitment) No. 12 to Lease
                                Dated as of February 5, 1998
                                Between SEQUENOM, INC.
                                and PHOENIX LEASING INCORPORATED

CONDITIONS OF THIS SCHEDULE AND OF THE MASTER EQUIPMENT LEASE DATED FEBRUARY 5,
1998 BETWEEN LESSEE AND LESSOR. THE TERMS AND CONDITIONS OF SUCH MASTER
EQUIPMENT LEASE ARE HEREBY INCORPORATED BY REFERENCE AND MADE A PART HEREOF TO
THE SAME EXTENT AS IF SUCH TERMS AND CONDITIONS WERE SET FORTH IN FULL HEREIN.

LESSOR:                                      LESSEE:

PHOENIX LEASING INCORPORATED                 SEQUENOM, INC.

By:         /s/                              By:              /s/
   ---------------------------------            -------------------------------
Name:       Lynn Sanders                     Name (Print):
      ------------------------------                      ---------------------
Title:      Contract Administrator           Title:
      ------------------------------               ----------------------------
Date:       2-1-99                           Date:            2-1-99
      ------------------------------               ----------------------------
<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A

<TABLE>
<CAPTION>
          Lessee: Sequenom, Inc.
                  --------------
                  11555 Sorrento Valley Road
Master Contact: 0135                                             Schedule: 12
                ----------------------                                     --
                                                                                                        Total
                                                                                                   L   Invoic'd
Item                                                                       Eq         Serial       O   Net of Sls    $ Pd By
 No    Vendor Name              Invoice No  Description of Item            Cd   Qty   Number       C      Tx          Lessee
- --------------------------------------------------------------------------------------------------------------------------------
<S>    <C>                      <C>         <C>                            <C>  <C>   <C>          <C> <C>           <C>
 1     A.G. HEINZE INC.         113170      Microscope System                2    1                1      2,720.80      2,720.80
- --------------------------------------------------------------------------------------------------------------------------------
 2     A.G. HEINZE INC.         113384      Auxiliary Object. for Micr       2    1                1        102.60        102.60
- --------------------------------------------------------------------------------------------------------------------------------
 3     BAAN BUSINESS SYSTEMS    B1011       SOFTWARE                        24   15                1    106,910.00    106,910.00
       - CA
- --------------------------------------------------------------------------------------------------------------------------------
 4     CONTINUUM                123146      MINILITE LASER                   2    1  3584          1     15,000.00          0.00
- --------------------------------------------------------------------------------------------------------------------------------
 5     FISHER SCIENTIFIC        5101592     FREEZER                          2    1                1      2,171.04      2,171.04
- --------------------------------------------------------------------------------------------------------------------------------
 6     FISHER SCIENTIFIC        5101592     FLAM MTRL STRG REF               2    1                1      2,260.91      2,260.91
- --------------------------------------------------------------------------------------------------------------------------------
 7     LASER SCIENCE            00007782    ADJUST. F/O COLLIMATOR           2    1                1      1,095.00
- --------------------------------------------------------------------------------------------------------------------------------
 8     LASER SCIENCE            00007782    FREIGHT                         27    1  1324          1         10.00
- --------------------------------------------------------------------------------------------------------------------------------
 9     LECROY                   C15336      WAIVEFOREM RETRO FIT KIT        24    1  AL019 563     1      1,250.00      1,250.00
- --------------------------------------------------------------------------------------------------------------------------------
10     MJ RESEARCH              53440       ALPHA POWER BONNET               2    1  AL019 564     1      4,855.50
- --------------------------------------------------------------------------------------------------------------------------------
11     MJ RESEARCH              53440       ALPHA POWER BONNET               2    1  AL019 729     1      4,855.50
- --------------------------------------------------------------------------------------------------------------------------------
12     MJ RESEARCH              53440       ALPHA POWER BONNET               2    1                1      4,855.50
- --------------------------------------------------------------------------------------------------------------------------------
13     MJ RESEARCH              53440       FREIGHT                         27    1                1         52.00
- --------------------------------------------------------------------------------------------------------------------------------
14     MICRON                   4221921     INTEL PEN II 450 MHZ SYSTEM      1    2                1      4,036.00      4,036.00
- --------------------------------------------------------------------------------------------------------------------------------
15     MICRON                   4261309     450 MGHZ MINI-TOWER SYSTEMS      1    5                1     11,011.00     11,011.00
- --------------------------------------------------------------------------------------------------------------------------------
16     MICRON                   4208919     400 MICRO TOWER SYS              1    1                1      1,768.00      1,768.00
- --------------------------------------------------------------------------------------------------------------------------------
17     MICRON                   4167115     33 MGHZ MICROTWR                 1    1                1      1,945.00      1,945.00
- --------------------------------------------------------------------------------------------------------------------------------
18     MOLECULAR BIOLOGY        497         PRIMER ANALYSIS SOFTWARE        24    1                1      1,200.00          0.00
- --------------------------------------------------------------------------------------------------------------------------------
19     MOLECULAR BIOLOGY        497         FREIGHT                         27    1                1         20.00
- --------------------------------------------------------------------------------------------------------------------------------
20     OFFICE FURNITURE OUTLET  3833        EXECUTIVE "U" UNIT               6    1                1      1,679.00      1,679.00
                                            W/CREDENZA'S
- --------------------------------------------------------------------------------------------------------------------------------
21     OFFICE FURNITURE OUTLET  3833        DEBONAIR LATERAL FILES           6    2                1        594.00        594.00
- --------------------------------------------------------------------------------------------------------------------------------

<CAPTION>
- --------------------------------------------------------------------------------------------------------
                                                                                    No entry required
                                             Tax Pd                         ----------------------------------
Item                                         Vndr?              Transact        Net $ Due      Net $ Due  P
 No          Vendor Name        Invoice No   (Y/N)    Chk No.     Date          Lessee         Vendor
- --------------------------------------------------------------------------------------------------------------
<S>    <C>                      <C>          <C>      <C>       <C>         <C>               <C>          <C>
    1  A.G. HEINZE INC.         113170       Y         4257       1/8/99       $  2,720.80    $  2,720.80  N
- --------------------------------------------------------------------------------------------------------------
    2  A.G. HEINZE INC.         113384       Y         4257       1/8/99       $    102.60    $    102.60  N
- --------------------------------------------------------------------------------------------------------------
    3  BAAN BUSINESS SYSTEMS    B1011        Y         4298      1/12/99       $106,910.00    $106,910.00  N
       - CA
- --------------------------------------------------------------------------------------------------------------
    4  CONTINUUM                123146       N                                 $      0.00    $      0.00  N
- --------------------------------------------------------------------------------------------------------------
    5  FISHER SCIENTIFIC        5101592      Y         4206       1/7/99       $  2,171.04    $  2,171.04  N
- --------------------------------------------------------------------------------------------------------------
    6  FISHER SCIENTIFIC        5101592      Y         4206       1/7/99       $  2,260.91    $  2,260.91  N
- --------------------------------------------------------------------------------------------------------------
    7  LASER SCIENCE            00007782     N                                 $      0.00    $      0.00  N
- --------------------------------------------------------------------------------------------------------------
    8  LASER SCIENCE            00007782     N                                 $      0.00    $      0.00  N
- --------------------------------------------------------------------------------------------------------------
    9  LECROY                   C15336       Y         4131     12/11/98       $  1,250.00    $  1,250.00  N
- --------------------------------------------------------------------------------------------------------------
   10  MJ RESEARCH              53440        Y                                 $      0.00    $      0.00  N
- --------------------------------------------------------------------------------------------------------------
   11  MJ RESEARCH              53440        Y                                 $      0.00    $      0.00  N
- --------------------------------------------------------------------------------------------------------------
   12  MJ RESEARCH              53440        Y                                 $      0.00    $      0.00  N
- --------------------------------------------------------------------------------------------------------------
   13  MJ RESEARCH              53440        Y                                 $      0.00    $      0.00  N
- --------------------------------------------------------------------------------------------------------------
   14  MICRON                   4221921      Y         4255       1/6/99       $  4,036.00    $  4,036.00  N
- --------------------------------------------------------------------------------------------------------------
   15  MICRON                   4261309      Y         4255       1/6/99       $ 11,011.00    $ 11,011.00  N
- --------------------------------------------------------------------------------------------------------------
   16  MICRON                   4208919      Y         3980     11/10/98       $  1,768.00    $  1,768.00  N
- --------------------------------------------------------------------------------------------------------------
   17  MICRON                   4167115      Y         4061     11/23/98       $  1,945.00    $  1,945.00  N
- --------------------------------------------------------------------------------------------------------------
   18  MOLECULAR BIOLOGY        497          N                                 $      0.00    $      0.00  N
- --------------------------------------------------------------------------------------------------------------
   19  MOLECULAR BIOLOGY        497          N                                 $      0.00    $      0.00  N
- --------------------------------------------------------------------------------------------------------------
   20  OFFICE FURNITURE OUTLET  3833         Y         4150     12/11/98       $  1,679.00    $  1,679.00  N
- --------------------------------------------------------------------------------------------------------------
   21  OFFICE FURNITURE OUTLET  3833         Y         4150     12/11/98       $    594.00    $    594.00  N
- --------------------------------------------------------------------------------------------------------------
</TABLE>
<PAGE>

                    Schedule (Additional Commitment) No. 12 to Lease
                    Dated as of February 5, 1998
                    Between SEQUENOM, INC.
                    and PHOENIX LEASING INCORPORATED

<TABLE>
- -----------------------------------------------------------------------------------------------------------------------------------
   <S> <C>                 <C>      <C>                 <C>  <C>     <C>    <C>       <C>    <C>  <C>  <C>         <C>
   22  OFFICE FURNITURE       3833  BOOKCASE 72" HIGH    6    2       1     388.00    388.00  Y   4150 12/11/98    $     388.00
       OUTLET
- -----------------------------------------------------------------------------------------------------------------------------------
   23  OFFICE FURNITURE       3833  FLORENCE ROUND       6    1       1     395.00    395.00  Y   4150 12/11/98    $     395.00
       OUTLET                       TABLE
- -----------------------------------------------------------------------------------------------------------------------------------
   24  OFFICE FURNITURE       3833  MULTI-TAXK CHAIRS    6    1       1     309.00    309.00  Y   4150 12/11/98    $     309.00
       OUTLET
- -----------------------------------------------------------------------------------------------------------------------------------
   25  OFFICE FURNITURE       3833  FOOT REST            6    1       1      39.00     39.00  Y   4150 12/11/98    $      39.00
       OUTLET
- -----------------------------------------------------------------------------------------------------------------------------------
   26  OFFICE FURNITURE       3833  SLED BASE            6    6       1     600.00    600.00  Y   4150 12/11/98    $     600.00
       OUTLET
- -----------------------------------------------------------------------------------------------------------------------------------
   27  ORACLE              1074022  ORACLE DEVELOPER    24    1       1   4,796.00      0.00  Y                    $       0.00
- -----------------------------------------------------------------------------------------------------------------------------------
   28  ORACLE              1074022  FREIGHT             27    1       1      15.00            Y                    $       0.00
- -----------------------------------------------------------------------------------------------------------------------------------
   29  PGC SCIENTIFICS      577011  ROTOR FOR CENTRI     2    1       1   1,035.00  1,035.00  Y   4081  12/3/98    $   1,035.00
- -----------------------------------------------------------------------------------------------------------------------------------
   30  PGC SCIENTIFICS      577227  CENTRIFUGE           2    1       1   3,945.00  3,945.00  Y   4081  12/3/98    $   3,945.00
- -----------------------------------------------------------------------------------------------------------------------------------

                                                                                                                   ----------------
                                                                                                                   $ 143,159.35
                                                                                                                   ----------------

- --------------------------------------------------------------
   <S> <C>                    <C>        <C>          <C>
   22  OFFICE FURNITURE       3833       $    388.00  N
       OUTLET
- --------------------------------------------------------------
   23  OFFICE FURNITURE       3833       $    395.00  N
       OUTLET
- --------------------------------------------------------------
   24  OFFICE FURNITURE       3833       $    309.00  N
       OUTLET
- --------------------------------------------------------------
   25  OFFICE FURNITURE       3833       $     39.00  N
       OUTLET
- --------------------------------------------------------------
   26  OFFICE FURNITURE       3833       $    600.00  N
       OUTLET
- --------------------------------------------------------------
   27  ORACLE              1074022       $      0.00  N
- --------------------------------------------------------------
   28  ORACLE              1074022       $      0.00  N
- --------------------------------------------------------------
   29  PGC SCIENTIFICS      577011       $  1,035.00  N
- --------------------------------------------------------------
   30  PGC SCIENTIFICS      577227       $  3,945.00  N
- --------------------------------------------------------------

                                         --------------
                                         $ 36,754.50
                                         --------------
                                         $179,913.85
                                         --------------
</TABLE>


             Lesseee Signature:     /s/                      Date:  1/25/99
                               --------------------                ---------

<PAGE>

                        ADDITIONAL COMMITMENT SCHEDULE
                        ------------------------------


                              Schedule (Additional Commitment) No. 13 to Lease
                              Dated as of February 5, 1998
                              Between SEQUENOM, INC.
                              and PHOENIX LEASING INCORPORATED


A.  Description and Purchase Price of Equipment
    -------------------------------------------

<TABLE>
<CAPTION>

  Description of
   Equipment                                                                       Street Address
 (quantity, model                                                                  City, State and
 and serial number)     Purchase Price          Rent            Mfr./Vendor           County
- ----------------------------------------------------------------------------------------------------

See Exhibit A attached hereto
<S>                     <C>                     <C>             <C>                <C>
Total:                      $286,868.16            $7,802.81
</TABLE>

B.  Terms
    -----

Base Term:          The Base Term shall commence on the date the Equipment is
                    received, installed and accepted for use, as shown on the
                    Acceptance Notice, and continue for 42 full months after the
                    "Rent Start Date."

Rent Start Date:    This shall be the first day of the month following the month
                    during which the Base Term commences; provided, however,
                    that if the Equipment is accepted on the first day of the
                    month, the Rent Start Date shall commence on the same day
                    that the Base Term commences.

Lease Rate Factor:  (expressed as a percentage of Equipment's original Purchase
                    Price): 2.72%

Base Rent Due:      Payable on the Rent Start Date shall be (1) the first and
                    last Rental Amount including any sales of use tax and (2) an
                    amount equal to 1/30th of the monthly rental amount using a
                    rate of 2.72% multiplied by the number of days, if any,
                    between (and including) the date the Base Term commences and
                    (but not including) the Rent Start Date, except that, if the
                    date of the Acceptance Notice related to this Schedule is
                    dated on or after the 20th of the month, this amount shall
                    not be included in the Base Rent Due.
<PAGE>

                              Schedule (Additional Commitment) No. 13 to Lease
                              Dated as of February 5, 1998
                              Between SEQUENOM, INC.
                              and PHOENIX LEASING INCORPORATED

C.  Invoice Information:  Lessee's and Lessor's addresses for invoice purposes
    --------------------
for the Equipment on the Schedule shall be as follows:

Lessee's Invoice Address:        Remit Monthly Rental Amount To:
- -------------------------        -------------------------------
SEQUENOM, INC.                   PHOENIX LEASING INCORPORATED
11555 Sorento Valley Road        P.O. Box 200432
San Diego, CA  92121             Dallas, TX  75320-0432
Attention:  Mr. Steve Zaniboni, Vice President, Finance and Administration

D.  Casualty Values:  See attachment hereto.
    ----------------

E.  Special Provisions:  1.  Lessor's payment for Equipment hereunder is
    -------------------
conditioned on Lessor's satisfaction of the conditions set forth in Section 3 of
the Lease and 2. Sale Leaseback Addendum.

F.  End of Lease Position: (a) General.  Lessee shall be required to choose a
    ----------------------     --------
final purchase or extension requirement ("End of Lease Position") at the
expiration of the Base Term (as defined in the Schedule) of the first Schedule
to the Lease. That choice shall be an election of Lessee's End of Lease Position
for all, but not less than all, of the Equipment under all Schedules to the
Lease. Lessee shall provide written notice of its election to Lessor at least 90
days prior to the end of the Base Term of the first Schedule.

Any Equipment purchase election shall be a purchase of the Equipment, AS-IS,
WHERE-IS. Upon Lessor's receipt of the purchase price, Lessor shall issue to
Lessee an equipment bill of sale, transferring title to the Equipment to the
Lessee without any representation or warranty whatsoever. Lessee shall be
responsible for all applicable taxes in connection with any Equipment purchase.

In the event Lessee does not provide at least 90 days' prior written notice of
its election, Lessee shall be deemed to have elected Election No. 2.

At the expiration of the Base Term of the first Schedule Lessee shall be
required to elect to either:

Election No. 1:  Purchase the Equipment for 25% of the Equipment's original
- ---------------
purchase price; or

Election No. 2:  Extend the Schedule's Base Term for an additional 12 months
- ---------------
("Extended Term") for a monthly rate of 2.50% of the Equipment's original
purchase price.

At the expiration of the Extended Term, Lessee shall purchase the Equipment for
$1.00.

LESSOR AND LESSEE AGREE THAT THIS SCHEDULE SHALL CONSTITUTE A LEASE OF THE
EQUIPMENT DESCRIBED ABOVE, SUBJECT TO THE TERMS AND
<PAGE>

                              Schedule (Additional Commitment) No. 13 to Lease
                              Dated as of February 5, 1998
                              Between SEQUENOM, INC.
                              and PHOENIX LEASING INCORPORATED

CONDITIONS OF THIS SCHEDULE AND OF THE MASTER EQUIPMENT LEASE DATED FEBRUARY 5,
1998 BETWEEN LESSEE AND LESSOR. THE TERMS AND CONDITIONS OF SUCH MASTER
EQUIPMENT LEASE ARE HEREBY INCORPORATED BY REFERENCE AND MADE A PART HEREOF TO
THE SAME EXTENT AS IF SUCH TERMS AND CONDITIONS WERE SET FORTH IN FULL HEREIN.

LESSOR:                                      LESSEE:

PHOENIX LEASING INCORPORATED                 SEQUENOM, INC.

By: /s/                                      By: /s/
    -------------------------                   -----------------------------
Name: Lynn Sanders                           Name (Print):___________________
      -----------------------
Title: Contract Administrator                Title:__________________________
       ----------------------
Date: 2-1-99                                 Date: 2-1-99
      -----------------------                      --------------------------
<PAGE>

                          Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A

     Lessee:           Sequenom, Inc.
                       --------------
                       11555 Sorrento Valley Road

Master Contact:  0135                                    Schedule:   13
                 --------------------------------                    --

<TABLE>
<CAPTION>
- ----------------------------------------------------------------------------------------------------------------------------------
                                                                               L   Total Invoic'd     $ Pd By      Tax Pd
Item                 Invoice     Description of       Eq            Serial     O   Net of Sls Tx      Lessee        Vndr?    Chk
 No    Vendor Name     No            Item             Cd     Qty    Number     C                                    (Y/N)    No.
- ----------------------------------------------------------------------------------------------------------------------------------
<S>    <C>           <C>         <C>                  <C>    <C>    <C>        <C> <C>                <C>            <C>     <C>
1      Robocon Inc.  RUS98-3     Robotic Assembly      2      1                 1     88,962.72        88,962.72      N       4082
                                 System
- ----------------------------------------------------------------------------------------------------------------------------------
2      Robocon Inc.  RUS98-4     Robotic Assembly      2      1                 1     88,962.72        88,962.72      N       4193
                                 System
- ----------------------------------------------------------------------------------------------------------------------------------

3      Robocon Inc.  RUS98-11    Robotic Assembly      2      1                 1    108,942.72                       N
                                 System
- ----------------------------------------------------------------------------------------------------------------------------------

<CAPTION>

- ------------------------------------------------------------------------------------
Item                 Invoice        Transact
 No    Vendor Name     No             Date                No entry required
- ------------------------------------------------------------------------------------
                                                      Net $ Due       Net $ Due
                                                         Lessee          Vendor
- ------------------------------------------------------------------------------------
<S>    <C>           <C>            <C>           <C>             <C>
1      Robocon Inc.  RUS98-3        12/3/98         $ 88,962.72     $      0.00  P

- ------------------------------------------------------------------------------------
2      Robocon Inc.  RUS98-4        12/24/98        $ 88,962.72     $      0.00  N

- ------------------------------------------------------------------------------------

3      Robocon Inc.  RUS98-11                       $      0.00     $108,942.72  N

- ------------------------------------------------------------------------------------

                                              ---------------------------------
                                                    $177,925.44
                                              ---------------------------------
                                                                    $108,942.72
                                                             ------------------
                                                                    $286,868.16
                                                             ------------------
</TABLE>

       Lessee Signature:  /s/                   Date: 1/25/99
                        ----------------             ------------
<PAGE>

                        ADDITIONAL COMMITMENT SCHEDULE
                        ------------------------------


                              Schedule (Additional Commitment) No. 14 to Lease
                              Dated as of February 5, 1998
                              Between SEQUENOM, INC.
                              and PHOENIX LEASING INCORPORATED


A.  Description and Purchase Price of Equipment
    -------------------------------------------

<TABLE>
<CAPTION>
  Description of
    Equipment                                                                       Street Address
 (quantity, model                                                                   City, State and
 and serial number)     Purchase Price          Rent            Mfr./ Vendor           County
- ----------------------------------------------------------------------------------------------------
<S>                     <C>                     <C>             <C>                 <C>
See Exhibit A attached hereto

Total:                  $27,309.62              $742.82
</TABLE>


B.  Terms
    -----

Base Term:        The Base Term shall commence on the date the Equipment is
                  received, installed and accepted for use, as shown on the
                  Acceptance Notice, and continue for 42 full months after the
                  "Rent Start Date."

Rent Start Date:  This shall be the first day of the month following the month
                  during which the Base Term commences; provided, however, that
                  if the Equipment is accepted on the first day of the month,
                  the Rent Start Date shall commence on the same day that the
                  Base Term commences.

Lease Rate Factor:  (expressed as a percentage of Equipment's original Purchase
                    Price): 2.72%

Monthly Rental Payments in advance.

Base Rent Due:    Payable on the Rent Start Date shall be (1) the first and last
                  Rental Amount including any sales of use tax and (2) an amount
                  equal to 1/30th of the monthly rental amount using a rate of
                  2.72% multiplied by the number of days, if any, between (and
                  including) the date the Base Term commences and (but not
                  including) the Rent Start Date, except that, if the date of
                  the Acceptance Notice related to this Schedule is dated on or
                  after the 20th of the month, this amount shall not be included
                  in the Base Rent Due.
<PAGE>

C.  Invoice Information:  Lessee's and Lessor's addresses for invoice purposes
    --------------------
for the Equipment on the Schedule shall be as follows:

Lessee's Invoice Address:          Remit Monthly Rental Amount To:
- -------------------------          -------------------------------
SEQUENOM, INC.                     PHOENIX LEASING INCORPORATED
11555 Sorento Valley Road          P.O. Box 200432
San Diego, CA  92121               Dallas, TX  75320-0432
Attention:  Mr. Steve Zaniboni, Vice President, Finance and Administration

D.  Casualty Values:  See attachment hereto.
    ----------------

E.  Special Provisions:  1.  Lessor's payment for Equipment hereunder is
    -------------------
conditioned on Lessor's satisfaction of the conditions set forth in Section 3 of
the Lease and 2.  Sale Leaseback Addendum.

F.  End of Lease Position: (a) General.  Lessee shall be required to choose a
    ----------------------     --------
final purchase or extension requirement ("End of Lease Position") at the
expiration of the Base Term (as defined in the Schedule) of the first Schedule
to the Lease.  That choice shall be an election of Lessee's End of Lease
Position for all, but not less than all, of the Equipment under all Schedules to
the Lease.  Lessee shall provide written notice of its election to Lessor at
least 90 days prior to the end of the Base Term of the first Schedule.

Any Equipment purchase election shall be a purchase of the Equipment, AS-IS,
WHERE-IS.  Upon Lessor's receipt of the purchase price, Lessor shall issue to
Lessee an equipment bill of sale, transferring title to the Equipment to the
Lessee without any representation or warranty whatsoever.  Lessee shall be
responsible for all applicable taxes in connection with any Equipment purchase.

In the event Lessee does not provide at least 90 days' prior written notice of
its election, Lessee shall be deemed to have elected Election No. 2.

At the expiration of the Base Term of the first Schedule Lessee shall be
required to elect to either:

Election No. 1:     Purchase the Equipment for 25% of the Equipment's original
- ---------------
purchase price; or

Election No. 2:     Extend the Schedule's Base Term for an additional 12 months
- ---------------
("Extended Term") for a monthly rate of 2.50% of the Equipment's original
purchase price.

At the expiration of the Extended Term, Lessee shall purchase the Equipment for
$1.00.

LESSOR AND LESSEE AGREE THAT THIS SCHEDULE SHALL CONSTITUTE A LEASE OF THE
EQUIPMENT DESCRIBED ABOVE, SUBJECT TO THE TERMS AND
<PAGE>

CONDITIONS OF THIS SCHEDULE AND OF THE MASTER EQUIPMENT LEASE DATED FEBRUARY 5,
1998 BETWEEN LESSEE AND LESSOR. THE TERMS AND CONDITIONS OF SUCH MASTER
EQUIPMENT LEASE ARE HEREBY INCORPORATED BY REFERENCE AND MADE A PART HEREOF TO
THE SAME EXTENT AS IF SUCH TERMS AND CONDITIONS WERE SET FORTH IN FULL HEREIN.

LESSOR:                                   LESSEE:

PHOENIX LEASING INCORPORATED              SEQUENOM, INC.


By:         /s/                           By:             /s/
    -----------------------------------       ----------------------------------
Name:       Lynn Sanders                  Name (Print):   Elizabeth Anderson
      ---------------------------------                 ------------------------
Title:      Contract Administrator        Title:          Manager of Finance
       --------------------------------          -------------------------------
Date:       March 29, 1999                Date:           March 29, 1999
       --------------------------------          -------------------------------
<PAGE>

                          Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A
<TABLE>
<CAPTION>

Lessee:  Sequenom, Inc.
         ------------------------
         11555 Sorrento Valley Road

Master Contact: 0135                                             Schedule:       14
                -----------------                                            ----------
- ----------------------------------------------------------------------------------------------------------------------
                                                                                                   Total
                                                                                          L       Invoic'd
Item                       Invoice                                  Eq          Serial    O       Net of Sls
 No  Vendor Name           No           Description of Item         Cd    Qty  Number     C            Tx
- ------------------------------------------------------------------------------------------------------------------
<S>  <C>                   <C>          <C>                         <C>   <C>  <C>        <C>     <C>
 1   MICRON                4297740       MILLENIA                    1     1               1      2,047.00
- ------------------------------------------------------------------------------------------------------------------
 2                                       FREIGHT                     27    1               1         84.00
- ------------------------------------------------------------------------------------------------------------------
 3   INACOM                8279282       HP COLOR LASERJET            1    1    JPCB002574 1      6,673.00
                                         PRINTER &ASSEC
- ------------------------------------------------------------------------------------------------------------------
 4                                       FREIGHT                     27    1               1         83.77
- ------------------------------------------------------------------------------------------------------------------
 5   PGC SCIENTIFIC        579826        UNDERCOUNTER ICE MAKER      2     1               1      1,995.00
- ------------------------------------------------------------------------------------------------------------------
 6                                       SALES TAX                   29    1               1        154.61
- ------------------------------------------------------------------------------------------------------------------
 7   VWR                   19921630      BAL, ANALYT, BASIC           2    1               1      2,021.00
- ------------------------------------------------------------------------------------------------------------------
 8                                       SALES TAX                   29    1               1        156.63
- ------------------------------------------------------------------------------------------------------------------
 9   MJ RESEARCH           52347         ALPHA POWER BONNET           2    1     ALO18501  1      4,855.50
- ------------------------------------------------------------------------------------------------------------------
 10                                      FREIGHT                     27    1               1         51.00
- ------------------------------------------------------------------------------------------------------------------
 11                                      SALES TAX                   29    1               1        376.30
- ------------------------------------------------------------------------------------------------------------------
 12  FISCHER SCIENTIFIC    5932093       REFRG, MEDICAL               2    1               1      5,285.39
- ------------------------------------------------------------------------------------------------------------------
 13                                      SALES TAX                   29    1               1        409.62
- ------------------------------------------------------------------------------------------------------------------
 14  PNP COMPUTERS             746       ASUS P2BD INTEL              1    1               1      2,892.80
- ------------------------------------------------------------------------------------------------------------------
 15                                      SALES TAX                   29    1               1        224.00
- ------------------------------------------------------------------------------------------------------------------
 16
- ------------------------------------------------------------------------------------------------------------------

<CAPTION>
- ----------------------------------------------------------------------------
                                       Tax Pd                              No entry required
                                                                        ------------------------
Item                      $ Pd By       Vndr?       Chk     Transact    Net $ Due    Net $ Due
 No       Vendor Name     Lessee        (Y/N)       No.         Date       Lessee       Vendor
- ------------------------------------------------------------------------------------------------
<S>       <C>             <C>           <C>         <C>     <C>         <C>          <C>
 1        MICRON          2,047.00       N          4372    1/20/99     $ 2,047.00   $     0.00
- ------------------------------------------------------------------------------------------------
 2                           84.00       N          4372    1/20/99     $    84.00   $     0.00
- ------------------------------------------------------------------------------------------------
 3       INACOM           6,673.00       Y          4368    1/20/99     $ 6,673.00   $     0.00

- ------------------------------------------------------------------------------------------------
 4                           83.77       Y          4368    1/20/99     $    83.77   $     0.00
- ------------------------------------------------------------------------------------------------
 5       PGC SCIENTIFIC   1,995.00       Y          4378    1/20/99     $ 1,995.00   $     0.00
- ------------------------------------------------------------------------------------------------
 6                          154.61       Y          4378    1/20/99     $   154.61   $     0.00
- ------------------------------------------------------------------------------------------------
 7       VWR              2,021.00       Y          4336    1/15/99     $ 2,021.00   $     0.00
- ------------------------------------------------------------------------------------------------
 8                          156.63       Y          4336    1/15/99     $   156.63   $     0.00
- ------------------------------------------------------------------------------------------------
 9       MJ RESEARCH      4,855.50       Y          4473     2/4/99     $ 4,855.50   $     0.00
- ------------------------------------------------------------------------------------------------
 10                          51.00       Y          4473     2/4/99     $    51.00   $     0.00
- ------------------------------------------------------------------------------------------------
 11                         376.30       Y          4473     2/4/99     $   376.30   $     0.00
- ------------------------------------------------------------------------------------------------
 12  FISCHER SCIENTIFIC   5,285.39       Y          4464     2/4/99     $ 5,285.39   $     0.00
- ------------------------------------------------------------------------------------------------
 13                         409.62       Y          4464     2/4/99     $   409.62   $     0.00
- ------------------------------------------------------------------------------------------------
 14  PNP COMPUTERS        2,892.80       Y          4434    1/28/99     $ 2,892.80   $     0.00
- ------------------------------------------------------------------------------------------------
 15                         224.00       Y          4434    1/28/99     $   224.00   $     0.00
- ------------------------------------------------------------------------------------------------
 16
- ------------------------------------------------------------------------------------------------
                                                                        $27,309.62
                                                                        ------------------------
                                                                                     $     0.00
                                                                                    ------------
                                                                                     $27,309.62
                                                                                    ------------
</TABLE>


Lessee Signature:   /s/                             Date:  3/9/99
                 ------------------------                 -------
<PAGE>

                        ADDITIONAL COMMITMENT SCHEDULE
                        ------------------------------


                                Schedule (Additional Commitment) No. 15 to Lease
                                Dated as of February 5, 1998
                                Between SEQUENOM, INC.
                                and PHOENIX LEASING INCORPORATED


A.   Description and Purchase Price of Equipment
     -------------------------------------------

<TABLE>
<CAPTION>
  Description of
     Equipment                                                                 Street Address
  (quantity, model                                                             City, State and
 and serial number)     Purchase Price     Rent            Mfr./ Vendor          County
- ----------------------------------------------------------------------------------------------------

See Exhibit A attached hereto
<S>                     <C>                <C>             <C>                 <C>
Total:                  $93,048.59         $2,530.92
</TABLE>


B.  Terms
    -----

Base Term:          The Base Term shall commence on the date the Equipment is
                    received, installed and accepted for use, as shown on the
                    Acceptance Notice, and continue for 42 full months after the
                    "Rent Start Date."

Rent Start Date:    This shall be the first day of the month following the month
                    during which the Base Term commences; provided, however,
                    that if the Equipment is accepted on the first day of the
                    month, the Rent Start Date shall commence on the same day
                    that the Base Term commences.

Lease Rate Factor:  (expressed as a percentage of Equipment's original Purchase
                    Price): 2.72%

Monthly Rental Payments in advance.

Base Rent Due:      Payable on the Rent Start Date shall be (1) the first and
                    last Rental Amount including any sales of use tax and (2) an
                    amount equal to 1/30th of the monthly rental amount using a
                    rate of 2.72% multiplied by the number of days, if any,
                    between (and including) the date the Base Term commences and
                    (but not including) the Rent Start Date, except that, if the
                    date of the Acceptance Notice related to this Schedule is
                    dated on or after the 20th of the month, this amount shall
                    not be included in the Base Rent Due.

                                       92
<PAGE>

                                Schedule (Additional Commitment) No. 15 to Lease
                                Dated as of February 5, 1998
                                Between SEQUENOM, INC.
                                and PHOENIX LEASING INCORPORATED


C.  Invoice Information:  Lessee's and Lessor's addresses for invoice purposes
    --------------------
for the Equipment on the Schedule shall be as follows:

<TABLE>
<CAPTION>
Lessee's Invoice Address:                          Remit Monthly Rental Amount To:
- -------------------------                          -------------------------------
<S>                                                <C>
SEQUENOM, INC.                                     PHOENIX LEASING INCORPORATED
11555 Sorento Valley Road                          Department 05980
San Diego, CA 92121                                P.O. Box 39000
Attention:  Mr. Steve Zaniboni, Vice President,    San Francisco, CA 94139-5980
Finance and Administration
</TABLE>

D.  Casualty Values:  See attachment hereto.
    ----------------

E.  Special Provisions:  1.  Lessor's payment for Equipment hereunder is
    -------------------
conditioned on Lessor's satisfaction of the conditions set forth in Section 3 of
the Lease and 2.  Sale Leaseback Addendum.

F.  End of Lease Position: (a) General.  Lessee shall be required to choose a
    ----------------------     --------
final purchase or extension requirement ("End of Lease Position") at the
expiration of the Base Term (as defined in the Schedule) of the first Schedule
to the Lease.  That choice shall be an election of Lessee's End of Lease
Position for all, but not less than all, of the Equipment under all Schedules to
the Lease.  Lessee shall provide written notice of its election to Lessor at
least 90 days prior to the end of the Base Term of the first Schedule.

Any Equipment purchase election shall be a purchase of the Equipment, AS-IS,
WHERE-IS.  Upon Lessor's receipt of the purchase price, Lessor shall issue to
Lessee an equipment bill of sale, transferring title to the Equipment to the
Lessee without any representation or warranty whatsoever.  Lessee shall be
responsible for all applicable taxes in connection with any Equipment purchase.

In the event Lessee does not provide at least 90 days' prior written notice of
its election, Lessee shall be deemed to have elected Election No. 2.

At the expiration of the Base Term of the first Schedule Lessee shall be
required to elect to either:

Election No. 1:     Purchase the Equipment for 25% of the Equipment's original
- ---------------
purchase price; or

Election No. 2:     Extend the Schedule's Base Term for an additional 12 months
- ---------------
("Extended Term") for a monthly rate of 2.50% of the Equipment's original
purchase price.

At the expiration of the Extended Term, Lessee shall purchase the Equipment for
$1.00.

                                       93
<PAGE>

                                Schedule (Additional Commitment) No. 15 to Lease
                                Dated as of February 5, 1998
                                Between SEQUENOM, INC.
                                and PHOENIX LEASING INCORPORATED


LESSOR AND LESSEE AGREE THAT THIS SCHEDULE SHALL CONSTITUTE A LEASE OF THE
EQUIPMENT DESCRIBED ABOVE, SUBJECT TO THE TERMS AND CONDITIONS OF THIS SCHEDULE
AND OF THE MASTER EQUIPMENT LEASE DATED FEBRUARY 5, 1998 BETWEEN LESSEE AND
LESSOR.  THE TERMS AND CONDITIONS OF SUCH MASTER EQUIPMENT LEASE ARE HEREBY
INCORPORATED BY REFERENCE AND MADE A PART HEREOF TO THE SAME EXTENT AS IF SUCH
TERMS AND CONDITIONS WERE SET FORTH IN FULL HEREIN.

LESSOR:                              LESSEE:

PHOENIX LEASING INCORPORATED         SEQUENOM, INC.


By:         /s/                      By:              /s/
   ---------------------------          ---------------------------------
Name:    Lynn Sanders                Name (Print):
     -------------------------                    -----------------------
Title: Contract Administrator        Title:
      ------------------------             ------------------------------
Date:   5-28-99                      Date:       5-28-99
      ------------------------            -------------------------------

                                       94
<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A

       Lessee:  Sequenom, Inc.
                --------------------------
                11555 Sorrento Valley Road

Master Contact: 0135                             Schedule:  15
                --------------------------                  --

<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------------------------
Vendor Name   Invoice   Description of   Eq         Serial    O   Total Invoic'd   $ Pd By     Vndr?
              No        Item             Cd   Qty   Number    C    Net of Sls Tx    Lessee     (Y/N)
- -----------------------------------------------------------------------------------------------------------------
<S>          <C>        <C>              <C>  <C>   <C>       <C> <C>              <C>         <C>     <C>
GESIM        R990015    8 CHANNEL        2    1               1        41,168.01    41,168.01   N      WIRE
                        NANOPLOTTER
- -----------------------------------------------------------------------------------------------------------------
             R990016    1 CHANNEL        2    1               1        21,830.03    21,830.03   N      WIRE
                        NANOPLOTTER
- -----------------------------------------------------------------------------------------------------------------

             R990019    4 CHANNEL        2    1               1       30,050.55      30,050.55  N      WIRE
                        NANOPLOTTER
- -----------------------------------------------------------------------------------------------------------------

- -----------------------------------------------------------------------------------------------------------------

<CAPTION>
- --------------------------------------------------------------------------------
                                                            No entry required
                                                        ------------------------
Vendor Name   Invoice   Description of     Transact     Net $ due     Net $ due
              No        Item                   Date        Lessee        Vendor
- --------------------------------------------------------------------------------
<S>          <C>        <C>                <C>         <C>            <C>
GESIM        R990015    8 CHANNEL           4/14/99     $41,168.01    $     0.00
                        NANOPLOTTER
- --------------------------------------------------------------------------------
             R990016    1 CHANNEL            4/14/99    $21,830.03    $     0.00
                        NANOPLOTTER
- --------------------------------------------------------------------------------

             R990019    4 CHANNEL            4/14/99    $30,050.55    $     0.00
                        NANOPLOTTER
- --------------------------------------------------------------------------------
                                                        $     0.00    $     0.00
- --------------------------------------------------------------------------------

- --------------------------------------------------------------------------------
                                                        $93,048.59
- --------------------------------------------------------------------------------
                                                                      $     0.00
                                                                      ----------
                                                                      $93,048.59
                                                                      ----------
</TABLE>

                        Lessee Signature:    /s/       Date:     5/3/99
                                         -----------         -------------

                                       95
<PAGE>

                         ADDITIONAL COMMITMENT SCHEDULE
                         ------------------------------

                                Schedule (Additional Commitment) No. 16 to Lease
                                Dated as of February 5, 1998
                                Between SEQUENOM, INC.
                                and PHOENIX LEASING INCORPORATED

A.  Description and Purchase Price of Equipment
    -------------------------------------------

<TABLE>
<CAPTION>
   Description of
 Equipment (quantity,
     model and           Purchase                          Mfr./                Street Address
   serial number)         Price            Rent           Vendor                City, State and County
- -------------------      --------          ----           ------                ----------------------
See Exhibit A attached hereto.
<S>                     <C>                <C>            <C>                   <C>
Total:                   $31,256.60        $850.18
</TABLE>

B.  Terms
    -----

Base Term:          The Base Term shall commence on the date the Equipment is
                    received, installed and accepted for use, as shown on the
                    Acceptance Notice, and continue for 42 full months after the
                    "Rent Start Date."

Rent Start Date:    This shall be the first day of the month following the month
                    during which the Base Term commences; provided, however,
                    that if the Equipment is accepted on the first day of the
                    month, the Rent Start Date shall commence on the same day
                    that the Base Term commences.

Lease Rate Factor (expressed as a percentage of Equipment's original Purchase
Price):2.72%

Monthly Rental Payments in advance.

Base Rent Due:      Payable on the Rent Start Date shall be (1) the first and
                    last Rental Amount including any sales or use tax and (2) an
                    amount equal to 1/30th of the monthly rental amount using a
                    rate of 2.72% multiplied by the number of days, if any,
                    between (and including) the date the Base Term commences and
                    (but not including) the Rent Start Date, except that, if the
                    date of the Acceptance Notice related to this Schedule is
                    dated on or after the 20th of the month, this amount shall
                    not be included in the Base Rent Due.

C.  Invoice Information:  Lessee's and Lessor's addresses for invoice purposes
    -------------------
for the Equipment on the schedule shall be as follows:


Lessee's Invoice Address:           Remit Monthly Rental Amount To:
- -------------------------           -------------------------------
SEQUENOM, INC.                      PHOENIX LEASING INCORPORATED
11555 Sorrento Valley Road          Department 05980
San Diego, CA 92121                 P.O. Box 39000
                                    San Francisco, CA  94139-5980

Attention:  Mr. Steve Zaniboni,
            Vice President, Finance and Administration
<PAGE>

                                Schedule (Additional Commitment) No. 16 to Lease
                                Dated as of February 5, 1998
                                Between SEQUENOM, INC.
                                and PHOENIX LEASING INCORPORATED

D.  Casualty Values: See attachment hereto.
    ---------------

E.  Special Provisions: 1. Lessor's payment for Equipment hereunder is
    ------------------
conditioned on Lessor's satisfaction of the conditions set forth in Section 3 of
the Lease and 2. Sale Leaseback Addendum.

F.   End of Lease Position:(a) General.  Lessee shall be required to choose a
     ---------------------     -------
     final purchase or extension requirement ("End of Lease Position") at the
     expiration of the Base Term (as defined in the Schedule) of the first
     Schedule to the Lease. That choice shall be an election of Lessee's End of
     Lease Position for all, but not less than all of the Equipment under all
     Schedules to the Lease. Lessee shall provide written notice of its election
     to Lessor at least 90 days prior to the end of the Base Term of the first
     Schedule.

Any Equipment purchase election shall be a purchase of the Equipment, AS-IS,
WHERE-IS. Upon Lessor's receipt of the purchase price, Lessor shall issue to
Lessee an equipment bill of sale, transferring title to the Equipment to the
Lessee without any representation or warranty whatsoever. Lessee shall be
responsible for all applicable taxes in connection with any Equipment Purchase.

In the event Lessee does not provide at least 90 days' prior written notice of
its election, Lessee shall be deemed to have elected Election No. 2.

At the expiration of the Base Term of the first Schedule Lessee shall be
required to elect to either:

Election No. 1:  Purchase the Equipment for 25% of the Equipment's original
- --------------
purchase price; or

Election No. 2:  Extend the Schedule's Base Term for an additional 12 months
- --------------
("Extended Term") for a monthly rate of 2.50% of the Equipment's original
purchase price.

At the expiration of the Extended Term, Lessee shall purchase the Equipment for
$1.00.

LESSOR AND LESSEE AGREE THAT THIS SCHEDULE SHALL CONSTITUTE A LEASE OF THE
EQUIPMENT DESCRIBED ABOVE, SUBJECT TO THE TERMS AND CONDITIONS OF THIS SCHEDULE
AND OF THE MASTER EQUIPMENT LEASE DATED FEBRUARY 5, 1998 BETWEEN LESSEE AND
LESSOR.  THE TERMS AND CONDITIONS OF SUCH MASTER EQUIPMENT LEASE ARE HEREBY
INCORPORATED BY REFERENCE AND MADE A PART HEREOF TO THE SAME EXTENT AS IF SUCH
TERMS AND CONDITIONS WERE SET FORTH IN FULL HEREIN.

LESSOR:                                LESSEE:

PHOENIX LEASING INCORPORATED           SEQUENOM, INC.

By:  /s/ Lynn Sanders                  By:  /s/ E. Anderson
   --------------------------             ---------------------------------
Name:  Lynn Sanders                    Name (Print): Elizabeth Anderson
     ------------------------                       -----------------------
Title:  Contract Admin                 Title: Finance Mgr
      -----------------------                ------------------------------
Date:   6-1-99                         Date: 6-1-99
     ------------------------               -------------------------------
<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A


Lessee: SEQUENOM, INC.
        --------------------------
        11555 SORRENTO VALLEY ROAD
        SAN DIEGO, CA 94121

Master Contract:   0135                             Schedule:  16
                ----------                                   -------

<TABLE>
<CAPTION>
                                                                       Total
                                                                 L   Invoic'd $             Tax Pd
Item                Invoice Description      Eq         Serial   O   Net of Sls   $ Pd By    Vndr?    Chk
No    Vendor Name   No.     of Item          Cd   Qty   Number   C      Tax       Lessee     (Y/N)    No.
- ------------------------------------------------------------------------------------------------------------
<S>  <C>           <C>      <C>               <C>  <C>   <C>      <C> <C>          <C>        <C>      <C>
1     MICRON        4400705 MILLENNIA 400     1    1              1   2,065.00     2,065.00     N      5120
- ------------------------------------------------------------------------------------------------------------
                            FREIGHT           27   1              1     104.00       104.00     N      5120
- ------------------------------------------------------------------------------------------------------------
2                   4419515 MILLENNIA 400     1    3              1   5,256.00     5,256.00     N      5120
- ------------------------------------------------------------------------------------------------------------
                            FREIGHT           27   1              1     208.00       208.00     N      5120
- ------------------------------------------------------------------------------------------------------------
3                   4426958 MILLENNIA 400     1    1              1   1,825.00     1,825.00     N      5120
- ------------------------------------------------------------------------------------------------------------
                            FREIGHT           27   1              1      94.00        94.00     N      5120
- ------------------------------------------------------------------------------------------------------------
4                   4394221 MILLENNIA 400     1    1              1   1,850.00     1,850.00     N      4970
- ------------------------------------------------------------------------------------------------------------
                            FREIGHT           27   1                    104.00       104.00     N      4970
- ------------------------------------------------------------------------------------------------------------
5                   4399320 MILLENNIA 400     1    1              1   1,752.00     1,752.00     N      4970
- ------------------------------------------------------------------------------------------------------------
                            FREIGHT           27   1              1     104.00       104.00     N      4970
- ------------------------------------------------------------------------------------------------------------
6                   4399338 MILLENNIA 400     1    1              1   1,752.00     1,752.00     N      4970
- ------------------------------------------------------------------------------------------------------------
                            FREIGHT           27   1              1     104.00       104.00     N      4970
- ------------------------------------------------------------------------------------------------------------
7                   4400723 MILLENNIA 400     1    1              1   2,543.00     2,543.00     N      4970
- ------------------------------------------------------------------------------------------------------------
                            FREIGHT           27   1              1     104.00       104.00     N      4970
- ------------------------------------------------------------------------------------------------------------
8                   4378727 MILLENNIA 400     1    1              1   3,358.00     3,358.00     N      4822
- ------------------------------------------------------------------------------------------------------------
9                           FREIGHT           27   1              1      84.00        84.00     N      4822
- ------------------------------------------------------------------------------------------------------------
10                  4378726 MILLENNIA 350     1    1              1   2,226.00     2,226.00     N      4822
- ------------------------------------------------------------------------------------------------------------
11                          FREIGHT           27   1              1      84.00        84.00     N      4822
- ------------------------------------------------------------------------------------------------------------
12                  4375811 MILLENNIA 400     1    1              1   1,654.00     1,654.00     N      4822
- ------------------------------------------------------------------------------------------------------------
13                          FREIGHT           27   1              1     104.00       104.00     N      4822
- ------------------------------------------------------------------------------------------------------------
14                  4376643 MILLENNIA 400     1    2              1   3,386.00     3,386.00     N      4822
- ------------------------------------------------------------------------------------------------------------
15                          FREIGHT           27   1              1     208.00       208.00     N      4822
- ------------------------------------------------------------------------------------------------------------
16    INACOM        8462438 HP VECTRA VE      2    1              1   1,775.00     1,775.00     Y      5004
- ------------------------------------------------------------------------------------------------------------
17                          MICROSOFT PRO 97  24   1              1     493.00       493.00     Y      5004
- ------------------------------------------------------------------------------------------------------------
18                          FREIGHT           27   1              1      19.60        19.60     Y      5004
- ------------------------------------------------------------------------------------------------------------
19
- ------------------------------------------------------------------------------------------------------------

<CAPTION>
                                                               No entry required
                                                         -----------------------------
Item                Invoice  Description     Transact      Net $ Due      Net $ Due
No    Vendor Name   No.      of Item             Date         Lessee         Vendor
- --------------------------------------------------------------------------------------
<S>  <C>           <C>      <C>              <C>          <C>            <C>
1     MICRON        4400705  MILLENNIA 400    5/13/99      $ 2,065.00     $     0.00
- --------------------------------------------------------------------------------------
                             FREIGHT          5/13/99      $   104.00     $     0.00
- --------------------------------------------------------------------------------------
2                   4419515  MILLENNIA 400    5/13/99      $ 5,256.00     $     0.00
- --------------------------------------------------------------------------------------
                             FREIGHT          5/13/99      $   208.00     $     0.00
- --------------------------------------------------------------------------------------
3                   4426958  MILLENNIA 400    5/13/99      $ 1,825.00     $     0.00
- --------------------------------------------------------------------------------------
                             FREIGHT          5/13/99      $    94.00     $     0.00
- --------------------------------------------------------------------------------------
4                   4394221  MILLENNIA 400    4/22/99      $ 1,850.00     $     0.00
- --------------------------------------------------------------------------------------
                             FREIGHT          4/22/99      $   104.00     $     0.00
- --------------------------------------------------------------------------------------
5                   4399320  MILLENNIA 400    4/22/99      $ 1,752.00     $     0.00
- --------------------------------------------------------------------------------------
                             FREIGHT          4/22/99      $   104.00     $     0.00
- --------------------------------------------------------------------------------------
6                   4399338  MILLENNIA 400    4/22/99      $ 1,752.00     $     0.00
- --------------------------------------------------------------------------------------
                             FREIGHT          4/22/99      $   104.00     $     0.00
- --------------------------------------------------------------------------------------
7                   4400723  MILLENNIA 400    4/22/99      $ 2,543.00     $     0.00
- --------------------------------------------------------------------------------------
                             FREIGHT          4/22/99      $   104.00     $     0.00
- --------------------------------------------------------------------------------------
8                   4378727  MILLENNIA 400    3/30/99      $ 3,358.00     $     0.00
- --------------------------------------------------------------------------------------
9                            FREIGHT          3/30/99      $    84.00     $     0.00
- --------------------------------------------------------------------------------------
10                  4378726  MILLENNIA 350    3/30/99      $ 2,226.00     $     0.00
- --------------------------------------------------------------------------------------
11                           FREIGHT          3/30/99      $    84.00     $     0.00
- --------------------------------------------------------------------------------------
12                  4375811  MILLENNIA 400    3/30/99      $ 1,654.00     $     0.00
- --------------------------------------------------------------------------------------
13                           FREIGHT          3/30/99      $   104.00     $     0.00
- --------------------------------------------------------------------------------------
14                  4376643  MILLENNIA 400    3/30/99      $ 3,386.00     $     0.00
- --------------------------------------------------------------------------------------
15                           FREIGHT          3/30/99      $   208.00     $     0.00
- --------------------------------------------------------------------------------------
16    INACOM        8462438  HP VECTRA VE     4/22/99      $ 1,775.00     $     0.00
- --------------------------------------------------------------------------------------
17                           MICROSOFT PRO    4/22/99      $   493.00     $     0.00
- --------------------------------------------------------------------------------------
18                           FREIGHT          4/22/99      $    19.60     $     0.00
- --------------------------------------------------------------------------------------
19                                                         $     0.00     $     0.00
- --------------------------------------------------------------------------------------
                             TOTAL AMOUNT DUE TO LESSEE    $31,256.60
                                                             -------------------------
                                           TOTAL AMOUNT DUE TO VENDOR     $     0.00
                                                                          ------------
                                                           TOTAL DRAW     $31,256.60
                                                                          ------------
</TABLE>

Lessee Signature:  /s/ E. Anderson            Date:    6/8/99
                 ------------------------          -----------------
<PAGE>

                        ADDITIONAL COMMITMENT SCHEDULE
                        ------------------------------

                              Schedule (Additional Commitment) No. 17 to Lease
                              Dated as of February 5, 1998
                              Between SEQUENOM, INC.
                              and PHOENIX LEASING INCORPORATED


A.  Description and Purchase Price of Equipment
    -------------------------------------------

<TABLE>
<CAPTION>
 Description of
    Equipment                                             Street Address
(quantity, model      Purchase                 Mfr./      City, State and
and serial number)      Price       Rent      Vendor           County
- ------------------   ----------    ------    --------    -----------------
<S>                  <C>           <C>       <C>         <C>
     See Exhibit A attached hereto.

Total:                 $52,559.01      $1,429.61
</TABLE>

B.   Terms
     -----

Base Term:           The Base Term shall commence on the date the Equipment is
                     received, installed and accepted for use, as shown on the
                     Acceptance Notice, and continue for 42 full months after
                     the "Rent Start Date."

Rent Start Date:     This shall be the first day of the month following the
                     month during which the Base Term commences; provided,
                     however, that if the Equipment is accepted on the first day
                     of the month, the Rent Start Date shall commence on the
                     same day that the Base Term commences.

Lease Rate Factor    (expressed as a percentage of Equipment's original Purchase
                     Price): 2.72%

Monthly Rental Payments in advance.

Base Rent Due:       Payable on the Rent Start Date shall be (1) the first and
                     last Rental Amount including any sales or use tax and (2)
                     an amount equal to 1/30th of the monthly rental amount
                     using a rate of 2.72% multiplied by the number of days, if
                     any, between (and including) the date the Base Term
                     commences and (but not including) the Rent Start Date,
                     except that, if the date of the Acceptance Notice related
                     to this Schedule is dated on or after the 20th of the
                     month, this amount shall not be included in the Base Rent
                     Due.

C.   Invoice Information: Lessee's and Lessor's addresses for invoice purposes
     -------------------
for the Equipment on the Schedule shall be as follows:
<PAGE>

Lessee's Invoice Address:                     Remit Monthly Rental Amount To:
- -------------------------                     -------------------------------
SEQUENOM, INC.                                PHOENIX LEASING INCORPORATED
11555 Sorento Valley Road                     Department 05980
San Diego, CA 92121                           P.O. Box 39000
Attention: Mr. Steve Zaniboni,                San Francisco, CA 94139-5980
           Vice President, Finance and Administration

D.   Casualty Values: See attachment hereto.
     ---------------

                              Schedule (Additional Commitment) No. 17 to Lease
                              Dated as of February 5, 1998
                              Between SEQUENOM, INC.
                              and PHOENIX LEASING INCORPORATED

E.   Special Provisions: 1. Lessor's payment for Equipment hereunder is
     ------------------
conditioned on Lessor's satisfaction of the conditions set forth in Section 3 of
the Lease and 2. Sale Leaseback Addendum.

F.   End of Lease Position: (a) General.  Lessee shall be required to choose a
     ---------------------      -------
final purchase or extension requirement ("End of Lease Position") at the
expiration of the Base Term (as defined in the Schedule) of the first Schedule
to the Lease.  That choice shall be an election of Lessee's End of Lease
Position for all, but not less than all, of the Equipment under all Schedules to
the Lease.  Lessee shall provide written notice of its election to Lessor at
least 90 days prior to the end of the Base Term of the first Schedule.

Any Equipment purchase election shall be a purchase of the Equipment, AS-IS,
WHERE-IS. Upon Lessor's receipt of the purchase price, Lessor shall issue to
Lessee an equipment bill of sale, transferring title to the Equipment to the
Lessee without any representation or warranty whatsoever.  Lessee shall be
responsible for all applicable taxes in connection with any Equipment purchase.

In the event Lessee does not provide at least 90 days' prior written notice of
its election, Lessee shall be deemed to have elected Election No. 2.

At the expiration of the Base Term of the first Schedule Lessee shall be
required to elect to either:

Election No. 1:  Purchase the Equipment for 25% of the Equipment's original
- ---------------
purchase price; or

Election No. 2:  Extend the Schedule's Base Term for an additional 12 months
- ---------------
("Extended Term") for a monthly rate of 2.50% of the Equipment's original
purchase price.

At the expiration of the Extended Term, Lessee shall purchase the Equipment for
$1.00.
<PAGE>

LESSOR AND LESSEE AGREE THAT THIS SCHEDULE SHALL CONSTITUTE A LEASE OF THE
EQUIPMENT DESCRIBED ABOVE, SUBJECT TO THE TERMS AND CONDITIONS OF THIS SCHEDULE
AND OF THE MASTER EQUIPMENT LEASE DATED FEBRUARY 5,1998 BETWEEN LESSEE AND
LESSOR.  THE TERMS AND CONDITIONS OF SUCH MASTER EQUIPMENT LEASE ARE HEREBY
INCORPORATED BY REFERENCE AND MADE A PART HEREOF TO THE SAME EXTENT AS IF SUCH
TERMS AND CONDITIONS WERE SET FORTH IN FULL HEREIN.

LESSOR:                            LESSEE:

PHOENIX LEASING INCORPORATED             SEQUENOM, INC.

By:       /s/ Lynn Sanders               By:         /s/ Elizabeth Anderson
   ----------------------------------       ------------------------------------
Name:     Lynn Sanders                   Name (Print):     Elizabeth Anderson
     --------------------------------                 --------------------------
Title:    Contract Administrator         Title:
      -------------------------------          ---------------------------------
Date:     7-1-99                         Date:              7-1-99
      -------------------------------         ----------------------------------
<PAGE>

                          Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A

Lessee:  Sequenom Inc.
         --------------------------
         11555 Sorrento Valley Road

Master Contact:  0135                                           Schedule:   17
                 ------------------                                       ------

<TABLE>
<CAPTION>
- ---------------------------------------------------------------------------------------------------------------------------------
                                                                                                        Total
Item                                                                                Serial           Invoic'd $       $ Pd By
No       Vendor Name    Invoice No.        Description of Item       Eq Cd   Qty    Number     LOC  Net of Sls Tx     Lessee
- ---------------------------------------------------------------------------------------------------------------------------------
<S>     <C>            <C>            <C>                            <C>     <C>    <C>        <C>  <C>               <C>
  1     Beckman        361335ft01     spectrophometer                     2    2     4323571,    1      15,839.00      15,839.00
        Coulter                                                                        432572
- ---------------------------------------------------------------------------------------------------------------------------------
  2                                   nucleic accid software option      24    2                 1         664.00         664.00
- ---------------------------------------------------------------------------------------------------------------------------------
  3                                   accessory option board              2    2                 1         690.00         690.00
- ---------------------------------------------------------------------------------------------------------------------------------
  4                                   high performance transport          2    2                 1       4,208.00       4,208.00
- ---------------------------------------------------------------------------------------------------------------------------------
  5                                   single cell holder                  2    2                 1         760.00         760.00
- ---------------------------------------------------------------------------------------------------------------------------------
  6                                   single cell hld microcell           2    2                 1         896.00         896.00
- ---------------------------------------------------------------------------------------------------------------------------------
  7                                   micro-auto 12 cell holder           2    2                 1       2,032.00       2,032.00
- ---------------------------------------------------------------------------------------------------------------------------------
  8                                   cuvettes, rect.                     2    1                 1         295.68         295.68
- ---------------------------------------------------------------------------------------------------------------------------------
  9                                   micro cell 50 microliter            2    1                 1         333.70         333.70
- ---------------------------------------------------------------------------------------------------------------------------------
 10                                   multi-microcell 4-position          2    6                 1       4,815.36       4,815.36
- ---------------------------------------------------------------------------------------------------------------------------------
 11                                   data capture network                2    2                 1       1,200.00       1,200.00
- ---------------------------------------------------------------------------------------------------------------------------------
 12                                   freigt & insurance                 27    1                 1         259.00         259.00
- ---------------------------------------------------------------------------------------------------------------------------------
 13                                   sales tax                          29    1                 1       2,459.36       2,459.36
- ---------------------------------------------------------------------------------------------------------------------------------
 14     Emplex               9992     Heat sealer                         2    1                 1       8,000.00       8,000.00
        Systems
- ---------------------------------------------------------------------------------------------------------------------------------
 15                                   freight                            27    1                 1         237.58         237.58
- ---------------------------------------------------------------------------------------------------------------------------------
 16     PE Biosystems    90335466     kit topfill                         2    1                 1       5,087.50       5,087.50
- ---------------------------------------------------------------------------------------------------------------------------------
 17                                   freight                            27    1                 1          32.50          32.50
- ---------------------------------------------------------------------------------------------------------------------------------
 18                                   sales tax                          29    1                 1         394.29         394.29
- ---------------------------------------------------------------------------------------------------------------------------------
 19     SGE Inc             78967     active film multiplier              2    1                 1       1,300.00       1,300.00
- ---------------------------------------------------------------------------------------------------------------------------------
 20                                   freight                            27    1                 1          13.45          13.45
- ---------------------------------------------------------------------------------------------------------------------------------
 21     VWR                428843     vacuubrand diaphram pump            2    1                 1       1,689.90       1,689.90
- ---------------------------------------------------------------------------------------------------------------------------------
 22                                   sales tax                          29    1                 1         130.97         130.97
- ---------------------------------------------------------------------------------------------------------------------------------
 23                      29342280     oven, vacuum                        2    1                 1       1,132.92       1,132.92
- ---------------------------------------------------------------------------------------------------------------------------------
 24                                   sales tax                          29    1                 1          87.80          87.80
- ---------------------------------------------------------------------------------------------------------------------------------
 25
- ---------------------------------------------------------------------------------------------------------------------------------

<CAPTION>
- -----------------------------------------------------------------------------------------------------
                                                                                    No entry Required
                                                                           --------------------------
Item                                    Tax Pd               Transact      Net $ Due      Net $ Due
No       Vendor Name    Invoice No.   Vndr? (Y/N)  Chk No.     Date         Lessee         Vendor
- -----------------------------------------------------------------------------------------------------
<S>     <C>            <C>            <C>          <C>       <C>           <C>            <C>
  1     Beckman        361335ft01              y      5014      4/28/99     $15,839.00          $0.00
        Coulter
- -----------------------------------------------------------------------------------------------------
  2                                            y      5014      4/28/99     $   664.00          $0.00
- -----------------------------------------------------------------------------------------------------
  3                                            y      5014      4/28/99         690.00          $0.00
- -----------------------------------------------------------------------------------------------------
  4                                            y      5014      4/28/99       4,208.00          $0.00
- -----------------------------------------------------------------------------------------------------
  5                                            y      5014      4/28/99         760.00          $0.00
- -----------------------------------------------------------------------------------------------------
  6                                            y      5014      4/28/99         896.00          $0.00
- -----------------------------------------------------------------------------------------------------
  7                                            y      5014      4/28/99       2,032.00          $0.00
- -----------------------------------------------------------------------------------------------------
  8                                            y      5014      4/28/99         295.68          $0.00
- -----------------------------------------------------------------------------------------------------
  9                                            y      5014      4/28/99         333.70          $0.00
- -----------------------------------------------------------------------------------------------------
 10                                            y      5014      4/28/99       4,815.36          $0.00
- -----------------------------------------------------------------------------------------------------
 11                                            y      5014      4/28/99       1,200.00          $0.00
- -----------------------------------------------------------------------------------------------------
 12                                            y      5014      4/28/99         259.00          $0.00
- -----------------------------------------------------------------------------------------------------
 13                                            y      5014      4/28/99       2,459.36          $0.00
- -----------------------------------------------------------------------------------------------------
 14     Emplex               9992              n      5341      6/17/99       8,000.00          $0.00
        Systems
- -----------------------------------------------------------------------------------------------------
 15                                            n      5341      6/17/99         237.58          $0.00
- -----------------------------------------------------------------------------------------------------
 16     PE Biosystems    90335466              y      5275       6/3/99       5,087.50          $0.00
- -----------------------------------------------------------------------------------------------------
 17                                            y      5275       6/3/99          32.50          $0.00
- -----------------------------------------------------------------------------------------------------
 18                                            y      5275       6/3/99         394.29          $0.00
- -----------------------------------------------------------------------------------------------------
 19     SGE Inc             78967              y      5221      5/27/99       1,300.00          $0.00
- -----------------------------------------------------------------------------------------------------
 20                                            y      5221      5/27/99          13.45          $0.00
- -----------------------------------------------------------------------------------------------------
 21     VWR                428843              y      5365      6/17/99       1,689.90          $0.00
- -----------------------------------------------------------------------------------------------------
 22                                            y      5365      6/17/99         130.97          $0.00
- -----------------------------------------------------------------------------------------------------
 23                      29342280              y      5234      5/27/99       1,132.92          $0.00
- -----------------------------------------------------------------------------------------------------
 24                                            y      5234      5/27/99          87.80          $0.00
- -----------------------------------------------------------------------------------------------------
 25                                                                               0.00          $0.00
- -----------------------------------------------------------------------------------------------------

                                                                            -------------------------
                                                 TOTAL AMOUNT DUE TO LESSEE $52,559.01          $0.00
                                                                            -------------------------
                                                            TOTAL AMOUNT DUE TO VENDOR          $0.00
                                                                                           ----------
Lessee Signature:   /s/ E. Anderson           Date:  7/6/99                 TOTAL DRAW     $52,559.01
                  -------------------               --------                               ----------
</TABLE>
<PAGE>

                    ATTACHMENT TO EQUIPMENT SCHEDULE NO. 17

                                CASUALTY VALUES


Month of       % of Original Equipment   Month of   % of Original Equipment
Lease Term        Purchase Price       Lease Term      Purchase Price
- -----------        --------------       ----------      --------------

     1                  125.00              22                73.78
     2                  122.56              23                71.34
     3                  120.12              24                68.90
     4                  117.68              25                66.46
     5                  115.24              26                64.02
     6                  112.80              27                61.59
     7                  110.37              28                59.15
     8                  107.93              29                56.71
     9                  105.49              30                54.27
     10                 103.05              31                51.83
     11                 100.61              32                49.39
     12                  98.17              33                46.95
     13                  95.73              34                44.51
     14                  93.29              35                42.07
     15                  90.85              36                39.63
     16                  88.41              37                37.20
     17                  85.98              38                34.76
     18                  83.54              39                32.32
     19                  81.10              40                29.88
     20                  78.66              41                27.44
     21                  76.22              42                25.00
                                                Thereafter    25.00




Lessor's                                        Lessee's
Initials  /s/  LS                               Initials  /s/ EA
          --------                                       ----------
<PAGE>

                               ACCEPTANCE NOTICE

                    SCHEDULE (ADDITIONAL COMMITMENT) NO. 17

Reference is made to the Master Equipment Lease dated as of February 5, 1998
between PHOENIX LEASING INCORPORATED as Lessor and SEQUENOM, INC. as Lessee (the
"Lease").

Lessee confirms that the following Equipment has been received, installed and is
ready for use by Lessee.  The Equipment is satisfactory in all respects for the
purposes of this Lease as of the date Lessee executes this Notice below.

Description of
 Equipment
(quantity, model    Purchase           Mfr./      Street Address City
and serial number)  Price      Rent    Vendor       State and County
- -----------------   -----      ----    ------      ------------------

     See Exhibit A attached hereto.

Total:            $52,559.01  $1,429.61


THE LEASE MAY NOT BE CHANGED, ALTERED OR MODIFIED EXCEPT BY AN INSTRUMENT IN
WRITING SIGNED BY AN OFFICER OF LESSOR AND A DULY AUTHORIZED REPRESENTATIVE OF
LESSEE.

IN WITNESS WHEREOF, Lessee has executed this Acceptance Notice as of July 1,
                                                                     ------
1999


                         SEQUENOM, INC.

                         By:    /s/  Elizabeth Anderson
                            ----------------------------------
                         Name:    Elizabeth Anderson
                              --------------------------------
                         Title:      Finance Manager
                               -------------------------------
<PAGE>

                              SALE LEASEBACK ADDENDUM
                              to Schedule (Additional Commitment) No. 17
                              of MASTER EQUIPMENT LEASE
                              Dated as of February 5, 1998
                              Between SEQUENOM, INC.
                              and PHOENIX LEASING INCORPORATED


This Addendum to Master Equipment Lease is made and entered into as of   July 1,
                                                                         ------
1999 between PHOENIX LEASING INCORPORATED ("Lessor") and SEQUENOM, INC.
("Lesee"').

Notwithstanding anything to the contrary contained in the Lease, as amended,
referenced above, Lessor and Lessee agree as follows:

1.   Lessee shall sell the Additional Equipment to and lease the Additional
     Equipment from Lessor and Lessor shall purchase the Additional Equipment
     from and lease the Additional Equipment to Lessee upon the terms and
     conditions of the Bill of Sale attached hereto as Attachment 1.

2.   Lessee represents and warrants that:

     (a) Lessee has the right to sell the Additional Equipment as set forth
     herein,

     (b) the Additional Equipment and Lessee's right, title and interest in such
     Additional Equipment is, as of the date of the Bill of Sale, free from all
     claims, liens, security interests and encumbrances,

     (c) Lessee will defend the sale against lawful claims and demands of all
     persons, and

     (d) the purchase price of the Additional Equipment is equal to the fair
     market value of such Additional Equipment at the time of sale.


LESSOR:                                      LESSEE:

PHOENIX LEASING INCORPORATED                 SEQUENOM, INC.

By:  /s/  Lynn Sanders                       By:  /s/  Elizabeth Anderson
   ---------------------------------            ------------------------------
Name:       Lynn Sanders                     Name:        Elizabeth Anderson
     -------------------------------               ----------------------------

Title:    Contract Admin                     Title:  Finance Mgr
      ------------------------------                ----------------------------
<PAGE>

                                  ATTACHMENT 1
                                  BELL OF SALE


For valuable consideration SEQUENOM, INC. ("Seller") sells to PHOENIX LEASING
INCORPORATED ("Buyer"), the property listed on Exhibit A hereof (the "Additional
Equipment").

Seller covenants and warrants that:

(1)  It is the owner of, and has absolute title to, the Additional Equipment
     which is free and clear of all claims, liens and encumbrances.

(2)  It has not made any prior sale, assignment, or transfer of the Additional
     Equipment.

(3)  It has the present right, power, and authority to sell the Additional
     Equipment to Buyer.

(4)  All action has been taken which is required to make this Bill of Sale a
     legal, valid and binding obligation of Seller.

Seller shall forever warrant and defend the sale of the Additional Equipment to
Buyer, its successors and assigns, against any person claiming an interest in
the Additional Equipment.

This Bill of Sale is binding on the successors and assigns of Seller and inures
to the benefit of the successors and assigns of Buyer.

Executed on July 1, 1999
            ------    --

                         SEQUENOM, INC.

                         By:  /s/ Elizabeth Anderson
                            ----------------------------------

                         Name:        Elizabeth Anderson
                              ---------------------------------

                         Title:       Finance Manager
                               --------------------------------
<PAGE>

                             OFFICER'S CERTIFICATE
                             ---------------------


The undersigned, Elizabeth Anderson, hereby certifies that:
                 ------------------

i)  I am the Financial Manager of SEQUENOM, INC., a Delaware corporation;

ii)  as such officer, I am familiar with the terms and conditions of that
     certain Master Equipment Lease dated as of February 5, 1998 as amended by
     Amendment No. 2 (the "Lease") between SEQUENOM, INC. ("Lessee") and PHOENIX
     LEASING INCORPORATED ("Lessor");

iii)  this certificate is delivered in connection with the leasing of certain
     equipment under an Additional Commitment Schedule with Lessor, the
     equipment is described in the Additional Commitment Schedule and the
     equipment is free and clear from any and all liens, charges, security
     interests or other encumbrances which may affect Lessor's right, title or
     interest in and to the equipment;

iv)  there has been no material adverse change in the financial condition of
     Lessee from the date of its most recent financial statements, true copies
     of which have been delivered to Lessor; and

v)   no event which, with the giving of notice or passage of time, or both,
     could become an Event of Default under the Lease has occurred and is
     continuing.

(vi) Lessee is performing according to Lessee's business plan described in
     Section 3 of the Lease, a true copy of which business plan has been
     delivered to Lessor;

(vii)the representations and warranties in Section 5 of the Lease are true and
     correct as of the date hereof.

IN WITNESS WHEREOF, I hereby execute this certificate on this 6th day of
                                                              ---
July, 1999.
- -----   --


                                                  /s/  E. Anderson
                                              ---------------------------
<PAGE>

                         ADDITIONAL COMMITMENT SCHEDULE
                         ------------------------------

                              Schedule (Additional Commitment) No. 18 to Lease
                              Dated as of February 5, 1998
                              Between SEQUENOM, INC.
                              and PHOENIX LEASING INCORPORATED

A.  Description and Purchase Price of Equipment
    -------------------------------------------



  Description of
   Equipment                                                    Street Address
 (quantity, model                                               City, State and
 and serial number)   Purchase Price    Rent    Mfr./Vendor          County
 -----------------    --------------    ----    -----------          ------
  See Exhibit A attached hereto.

Total:                $60,449.99      $1,644.24

B.  Terms
    -----

Base Term:            The Base Term shall commence on the date the Equipment is
                      received, installed and accepted for use, as shown on the
                      Acceptance Notice, and continue for 42 full months after
                      the "Rent Start Date."

Rent Start Date:      This shall be the first day of the month following the
                      month during which the Base Term commences; provided,
                      however, that if the Equipment is accepted on the first
                      day of the month, the Rent Start Date shall commence on
                      the same day that the Base Term commences.

Lease Rate Factor     (expressed as a percentage of Equipment's original
                      Purchase Price): 2.72%

Monthly Rental Payments in advance.

Base Rent Due:         Payable on the Rent Start Date shall be (1) the first and
                       last Rental Amount including any sales or use tax and (2)
                       an amount equal to 1/30th of the monthly rental amount
                       using a rate of 2.72% multiplied by the number of days,
                       if any, between (and including) the date the Base Term
                       commences and (but not including) the Rent Start Date,
                       except that, if the date of the Acceptance Notice related
                       to this Schedule is dated on or after the 20th of the
                       month, this amount shall not be included in the Base Rent
                       Due.

C. Invoice Information: Lessee's and Lessor's addresses for invoice purposes for
   -------------------
the Equipment on the Schedule shall be as follows:

Lessee's Invoice Address:           Remit Monthly Rental Amount To:
- ------------------------            ------------------------------
SEQUENOM, INC.                      PHOENIX LEASING INCORPORATED
11555 Sorento Valley Road           Department 05980
San Diego, CA 92121                 P.O. Box 39000
Attention: Mr. Steve Zaniboni,      San Francisco, CA 94139-5980
           Vice President, Finance and Administration
<PAGE>

                        Schedule (Additional Commitment) No. 18 to Lease
                        Dated as of February 5, 1998
                        Between SEQUENON, INC.
                        and PHOENIX LEASING INCORPORATED

D.     Casualty Values: See attachment hereto.
       ---------------

E.     Special Provisions: 1. Lessor's payment for Equipment hereunder is
       ------------------
conditioned on Lessor's satisfaction of the conditions set forth in Section 3 of
the Lease and 2. Sale Leaseback Addendum.

F.     End of Lease Position: (a) General.  Lessee shall be required to choose a
       ---------------------      -------
final purchase or extension requirement ("End of Lease Position") at the
expiration of the Base Term (as defined in the Schedule) of the first Schedule
to the Lease.  That choice shall be an election of Lessee's End of Lease
Position for all, but not less than all, of the Equipment under all Schedules to
the Lease.  Lessee shall provide written notice of its election to Lessor at
least 90 days prior to the end of the Base Term of the first Schedule.

Any Equipment purchase election shall be a purchase of the Equipment, AS-IS,
WHERE-IS.  Upon Lessor's receipt of the purchase price, Lessor shall issue to
Lessee an equipment bill of sale, transferring title to the Equipment to the
Lessee without any representation or warranty whatsoever.  Lessee shall be
responsible for all applicable taxes in connection with any Equipment purchase.

In the event Lessee does not provide at least 90 days' prior written notice of
its election, Lessee shall be deemed to have elected Election No. 2.

At the expiration of the Base Term of the first Schedule Lessee shall be
required to elect to either:

Election No. 1: Purchase the Equipment for 25% of the Equipment's original
- -------- --- -
purchase price; or

Election No. 2: Extend the Schedule's Base Term for an additional 12 months
- -------- --- -
("Extended Term") for a monthly rate of 2.50% of the Equipment's original
purchase price.

At the expiration of the Extended Term, Lessee shall purchase the Equipment for
$1.00.

LESSOR AND LESSEE AGREE THAT THIS SCHEDULE SHALL CONSTITUTE A LEASE OF THE
EQUIPMENT DESCRIBED ABOVE, SUBJECT TO THE TERMS AND CONDITIONS OF THIS SCHEDULE
AND OF THE MASTER EQUIPMENT LEASE DATED FEBRUARY 5, 1998 BETWEEN LESSEE AND
LESSOR.  THE TERMS AND CONDITIONS OF SUCH MASTER EQUIPMENT LEASE ARE HEREBY
INCORPORATED BY REFERENCE AND MADE A PART HEREOF TO THE SAME EXTENT AS IF SUCH
TERMS AND CONDITIONS WERE SET FORTH IN FULL HEREIN.

LESSOR:                                         LESSEE:

PHOENIX LEASING INCORPORATED                    SEQUENOM, INC.

By:    /s/ Lynn Sanders                         By:    /s/ E. Anderson
   -----------------------------                   ----------------------------
Name:  Lynn Sanders                             Name (Print):Elizabeth Anderson
     ---------------------------                             ------------------
Title: Contract Admin                           Title:  Finance Manager
      --------------------------                      -------------------------
Date:  8-1-99                                   Date:   8-1-99
     ---------------------------                     --------------------------
<PAGE>

                          Phoenix Leasing Incorporated

                                Funding Request

                                   Exhibit A

<TABLE>
<CAPTION>
        Lessee:  SEQUENOM, INC.
                 --------------------
                 11555 SORRENTO VALLEY ROAD

Master Contract:  0135                                           Schedule: 18
                 --------                                                 ----
                                                                                     L            Total
Item                    Invoice   Description                   Eq   Qty    Serial   O           Invoic'd
No.    Vendor Name      No.       of Item                       Cd          Number   C         Net of Sls Tx
- --------------------------------------------------------------------------------------------------------------
<S>    <C>              <C>       <C>                           <C>  <C>    <C>      <C>      <C>
 1     MICRON           4472513   MILLENNIA SYSTEM              1     1              1         1,733.99
- --------------------------------------------------------------------------------------------------------------
 2                                FREIGHT                       27    1              1           104.00
- --------------------------------------------------------------------------------------------------------------
 3                      4464433   MILLENNIA SYSTEM              1     1              1         1,725.00
- --------------------------------------------------------------------------------------------------------------
4                                 FREIGHT                       27    1              1           104.00
- --------------------------------------------------------------------------------------------------------------
5                       4465333   MILLENNIA SYSTEM              1     1              1         1,725.00
- --------------------------------------------------------------------------------------------------------------
6                                 FREIGHT                       27    1              1           104.00
- --------------------------------------------------------------------------------------------------------------
7                       4462166   MILLENNIA SYSTEM              1     1              1          1,974.00
- --------------------------------------------------------------------------------------------------------------
8                                 FREIGHT                       27    1              1             54.00
- --------------------------------------------------------------------------------------------------------------
9      GESIM            R990059   NANO PLOTTER                  2     1              1         15,701.95
- --------------------------------------------------------------------------------------------------------------
10                                video monitor 12"             2     1              1            456.82
- --------------------------------------------------------------------------------------------------------------
11                                pkging for transportation     27    1              1            122.56
- --------------------------------------------------------------------------------------------------------------
12                      R990058   NANO PLOTTER                  2     1              1         15,701.95
- --------------------------------------------------------------------------------------------------------------
13                                video monitor 12"             2     1              1            456.82
- --------------------------------------------------------------------------------------------------------------
14                                pkging for transportation     27    1              1            122.56
- --------------------------------------------------------------------------------------------------------------
15                      R990018   1-CHANNEL NANO PLOTTER        2     1              1         19,968.54
- --------------------------------------------------------------------------------------------------------------
16                                pkging for transportation     27    1              1            394.80
- --------------------------------------------------------------------------------------------------------------
17
- --------------------------------------------------------------------------------------------------------------

<CAPTION>
- ------------------------------------------------------------------------------------------------------------------
                                                                                      No entry required
                                                                               -----------------------------------
Item                    Invoice    $ Pd by     Vndr               Transact       Net $ Due         Net $ Due
No.    Vendor Name      No.        Lessee     (Y/N)    Chk No.        Date          Lessee            Vendor
- ------------------------------------------------------------------------------------------------------------------
<S>    <C>              <C>        <C>        <C>      <C>         <C>             <C>            <C>
 1     MICRON           4472513     1,733.99    N      5522        6/30/99         $ 1,733.99     $     0.00
- ------------------------------------------------------------------------------------------------------------------
 2                                    104.00    N      5522        6/30/99         $   104.00     $     0.00
- ------------------------------------------------------------------------------------------------------------------
 3                      4464433     1,725.00    N      5522        6/30/99         $ 1,725.00     $     0.00
- ------------------------------------------------------------------------------------------------------------------
4                                     104.00    N      5522        6/30/99         $   104.00     $     0.00
- ------------------------------------------------------------------------------------------------------------------
5                       4465333     1,725.00    N      5522        6/30/99         $ 1,725.00     $     0.00
- ------------------------------------------------------------------------------------------------------------------
6                                     104.00    N      5522        6/30/99         $   104.00     $     0.00
- ------------------------------------------------------------------------------------------------------------------
7                       4462166     1,974.00    N      5522        6/30/99         $ 1,974.00     $     0.00
- ------------------------------------------------------------------------------------------------------------------
8                                      54.00    N      5522        6/30/99         $    54.00     $     0.00
- ------------------------------------------------------------------------------------------------------------------
9      GESIM            R990059    15,701.95    N      WIRE        7/21/99         $15,701.95     $     0.00
- ------------------------------------------------------------------------------------------------------------------
10                                    456.82    N      WIRE        7/21/99         $   456.82     $     0.00
- ------------------------------------------------------------------------------------------------------------------
11                                    122.56    N      WIRE        7/21/99         $   122.56     $     0.00
- ------------------------------------------------------------------------------------------------------------------
12                      R990058    15,701.95    N      WIRE        7/21/99         $15,701.95     $     0.00
- ------------------------------------------------------------------------------------------------------------------
13                                    456.82    N      WIRE        7/21/99         $   456.82     $     0.00
- ------------------------------------------------------------------------------------------------------------------
14                                    122.56    N      WIRE        7/21/99         $   122.56     $     0.00
- ------------------------------------------------------------------------------------------------------------------
15                      R990018    19,968.54    N      WIRE        7/21/99         $19,968.54     $     0.00
- ------------------------------------------------------------------------------------------------------------------
16                                    394.80   N      WIRE        7/21/99          $   394.80     $     0.00
- ------------------------------------------------------------------------------------------------------------------
17                                                                                 $     0.00     $     0.00
- ------------------------------------------------------------------------------------------------------------------

                                                                                   -------------------------------
                                                     TOTAL AMOUNT DUE TO LESSEE    $60,449.99
                                                                                   -------------------------------
                                                                   TOTAL AMOUNT DUE TO VENDOR          $0.00
                                                                                                  ----------------
                                                                                   TOTAL DRAW     $60,449.99
                                                                                                  ----------------
</TABLE>


Lessee Signature:  /s/ E. Anderson        Date:    8/2/99
<PAGE>

                               ACCEPTANCE NOTICE

                    SCHEDULE (ADDITIONAL COMMITMENT) NO. 18

Reference is made to the Master Equipment Lease dated as of February 5, 1998
between PHOENIX LEASING INCORPORATED as Lessor and SEQUENOM, INC. as Lessee (the
"Lease").

Lessee confirms that the following Equipment has been received, installed and is
ready for use by Lessee.  The Equipment is satisfactory in all respects for the
purposes of this Lease as of the date Lessee executes this Notice below.


  Description of
   Equipment                                                  Street Address
 (quantity, model                                            City, State, and
 and serial number)   Purchase Price    Rent    Mfr./Vendor        County
 -----------------    --------------    ----    -----------        ------
   See Exhibit A attached hereto.




Total:                 $60,449.99      $1,644.24


THE LEASE MAY NOT BE CHANGED, ALTERED OR MODIFIED EXCEPT BY AN INSTRUMENT IN
WRITING SIGNED BY AN OFFICER OF LESSOR AND A DULY AUTHORIZED REPRESENTATIVE OF
LESSEE.

IN WITNESS WHEREOF, Lessee has executed this Acceptance Notice as of August 1,
1999.

                                    SEQUENOM, INC.

                                    By:  /s/ E. Anderson
                                       -------------------------------

                                    Name:    Elizabeth Anderson
                                         ------------------------------

                                    Title:   Finance Mgr.
                                          ------------------------------
<PAGE>



                         Phoenix Leasing Incorporated

                                Funding Request

                                   Exhibit A

<TABLE>
<CAPTION>
        Lessee:  SEQUENOM, INC.
                 ---------------------
                 11555 SORRENTO VALLEY ROAD

Master Contract:  0135                                                     Schedule:  18
                  -----                                                              ---


- ---------------------------------------------------------------------------------------------------------------------------
                                                                                   L         Toal
Item    Vendor Name    Invoice    Description                  Eq   Qty    Serial  O       Invoic'd $          $ Pd by
No.                    No.        of Item                      Cd          Number  C      Net of Sls Tx         Lessee
- ---------------------------------------------------------------------------------------------------------------------------
<S>     <C>            <C>        <C>                          <C>  <C>    <C>     <C>   <C>                   <C>
     1   MICRON        4472513    MILLENNIA SYSTEM              1     1            1          1,733.99         $ 1,733.99
- ---------------------------------------------------------------------------------------------------------------------------
     2                            FREIGHT                       27    1            1            104.00         $   104.00
- ---------------------------------------------------------------------------------------------------------------------------
     3                 4464433    MILLENNIA SYSTEM              1     1            1          1,725.00         $ 1,725.00
- ---------------------------------------------------------------------------------------------------------------------------
     4                            FREIGHT                       27    1            1            104.00         $   104.00
- ----------------------------------------------------------------------------------------------------------------------------
     5                 4465333    MILLENNIA SYSTEM              1     1            1          1,725.00         $ 1,725.00
- ----------------------------------------------------------------------------------------------------------------------------
     6                            FREIGHT                       27    1            1            104.00         $   104.00
- ----------------------------------------------------------------------------------------------------------------------------
     7                 4462166    MILLENNIA SYSTEM              1     1            1          1,974.00         $ 1,974.00
- ----------------------------------------------------------------------------------------------------------------------------
     8                            FREIGHT                       27    1            1             54.00         $    54.00
- ----------------------------------------------------------------------------------------------------------------------------
     9  GESIM          R990059    NANO PLOTTER                  2     1            1         15,701.95         $15,701.95
- ----------------------------------------------------------------------------------------------------------------------------
    10                            video monitor 12"             2     1            1            456.82         $   456.82
- ----------------------------------------------------------------------------------------------------------------------------
    11                            pkging for transportation     27    1            1            122.56         $   122.56
- ----------------------------------------------------------------------------------------------------------------------------
    12                 R990058    NANO PLOTTER                  2     1            1         15,701.95         $15,701.95
- ----------------------------------------------------------------------------------------------------------------------------
    13                            video monitor 12"             2     1            1            456.82         $   456.82
- ----------------------------------------------------------------------------------------------------------------------------
    14                            pkging for transportation     27    1            1            122.56         $   122.56
- ----------------------------------------------------------------------------------------------------------------------------
    15                 R990018    1-CHANNEL NANO PLOTTER        2     1            1         19,968.54         $19,968.54
- ----------------------------------------------------------------------------------------------------------------------------
    16                            pkging for transportation     27    1            1            394.80         $   394.80
- ----------------------------------------------------------------------------------------------------------------------------
    17
- ----------------------------------------------------------------------------------------------------------------------------

<CAPTION>
- -------------------------------------------------------------------------------------------------------
                                                                           No entry required
                                                                    -----------------------------------
Item    Vendor Name    Invoice      Vndr               Transact       Net $ Due         Net $ Due
No.                    No.         (Y/N)    Chk No.        Date          Lessee            Vendor
- -------------------------------------------------------------------------------------------------------
<S>     <C>            <C>        <C>      <C>         <C>            <C>              <C>
     1   MICRON        4472513       N      5522        6/30/99         $ 1,733.99     $    $0.00
- -------------------------------------------------------------------------------------------------------
     2                               N      5522        6/30/99         $   104.00     $    $0.00
- -------------------------------------------------------------------------------------------------------
     3                 4464433       N      5522        6/30/99         $ 1,725.00     $    $0.00
- -------------------------------------------------------------------------------------------------------
     4                               N      5522        6/30/99         $   104.00     $    $0.00
- -------------------------------------------------------------------------------------------------------
     5                 4465333       N      5522        6/30/99         $ 1,725.00     $    $0.00
- -------------------------------------------------------------------------------------------------------
     6                               N      5522        6/30/99         $   104.00     $    $0.00
- -------------------------------------------------------------------------------------------------------
     7                 4462166       N      5522        6/30/99         $ 1,974.00     $    $0.00
- -------------------------------------------------------------------------------------------------------
     8                               N      5522        6/30/99         $    54.00     $    $0.00
- -------------------------------------------------------------------------------------------------------
     9  GESIM          R990059       N      WIRE        7/21/99         $15,701.95     $    $0.00
- -------------------------------------------------------------------------------------------------------
    10                               N      WIRE        7/21/99         $   456.82     $    $0.00
- -------------------------------------------------------------------------------------------------------
    11                               N      WIRE        7/21/99         $   122.56     $    $0.00
- -------------------------------------------------------------------------------------------------------
    12                 R990058       N      WIRE        7/21/99         $15,701.95     $    $0.00
- -------------------------------------------------------------------------------------------------------
    13                               N      WIRE        7/21/99         $   456.82     $    $0.00
- -------------------------------------------------------------------------------------------------------
    14                               N      WIRE        7/21/99         $   122.56     $    $0.00
- -------------------------------------------------------------------------------------------------------
    15                 R990018       N      WIRE        7/21/99         $19,968.54     $    $0.00
- -------------------------------------------------------------------------------------------------------
    16                               N      WIRE        7/21/99         $   394.80     $    $0.00
- -------------------------------------------------------------------------------------------------------
    17                                                                  $     0.00     $     0.00
- -------------------------------------------------------------------------------------------------------

                                                                        -------------------------------
                                          TOTAL AMOUNT DUE TO LESSEE    $60,449.99
                                                                        -------------------------------
                                                        TOTAL AMOUNT DUE TO VENDOR     $     0.00
                                                                                      -----------------
                                                                        TOTAL DRAW     $60,449.99
                                                                                      -----------------
</TABLE>


          Lessee Signature: /s/ E. Anderson          Date:   8/2/99
                            ---------------                  ------
<PAGE>

                    ATTACHMENT TO EQUIPMENT SCHEDULE NO. 18

                                CASUALTY VALUES

<TABLE>
<CAPTION>
      Month of     % of Original Equipment      Month of     % of Original Equipment
     Lease Term         Purchase Price         Lease Term         Purchase Price
    ------------  -------------------------   ------------  -------------------------
    <S>           <C>                         <C>           <C>
          1                 125.00                22                  73.78
          2                 122.56                23                  71.34
          3                 120.12                24                  68.90
          4                 117.68                25                  66.46
          5                 115.24                26                  64.02
          6                 112.80                27                  61.59
          7                 110.37                28                  59.15
          8                 107.93                29                  56.71
          9                 105.49                30                  54.27
         10                 103.05                31                  51.83
         11                 100.61                32                  49.39
         12                  98.17                33                  46.95
         13                  95.73                34                  44.51
         14                  93.29                35                  42.07
         15                  90.85                36                  39.63
         16                  88.41                37                  37.20
         17                  85.98                38                  34.76
         18                  83.54                39                  32.32
         19                  81.10                40                  29.88
         20                  78.66                41                  27.44
         21                  76.22                42                  25.00
                                                Thereafter            25.00
</TABLE>

     Lessor's                             Lessee's
     Initials /s/ LS                      Initials /s/ EA
             -----------                          -----------
<PAGE>

                                    SALE LEASEBACK ADDENDUM
                                    to Schedule (Additional Commitment) No. 18
                                    of MASTER EQUIPMENT LEASE
                                    Dated as of February 5, 1998
                                    Between SEQUENOM, INC.
                                    and PHOENIX LEASING INCORPORATED

This Addendum to Master Equipment Lease is made and entered into as of August 1,
1999 between PHOENIX LEASING INCORPORATED ("Lessor") and SEQUENOM, INC.
("Lessee").

Notwithstanding anything to the contrary contained in the Lease, as amended,
referenced above, Lessor and Lessee agree as follows:

1.   Lessee shall sell the Additional Equipment to and lease the Additional
     Equipment from Lessor and Lessor shall purchase the Additional Equipment
     from and lease the Additional Equipment to Lessee upon the terms and
     conditions of the Bill of Sale attached hereto as Attachment 1.

2.   Lessee represents and warrants that:

     (a)  Lessee has the right to sell the Additional Equipment as set forth
     herein,

     (b)  the Additional Equipment and Lessee's right, title and interest in
     such Additional Equipment is, as of the date of the Bill of Sale, free from
     all claims, liens, security interests and encumbrances,

     (c)  Lessee will defend the sale against lawful claims and demands of all
     persons, and

     (d)  the purchase price of the Additional Equipment is equal to the fair
     market value of such Additional Equipment at the time of sale.

LESSOR:                               LESSEE:

PHOENIX LEASING INCORPORATED          SEQUENOM, INC.

By:    /s/ Lynn Sanders               By:    /s/ E. Anderson
   -------------------------------       ---------------------------------
Name:  Lynn Sanders                   Name (Print): Elizabeth Anderson
     -----------------------------                  ----------------------
Title: Contract Admin                 Title: Finance Manager
      ----------------------------          ------------------------------
<PAGE>

                                 ATTACHMENT 1

                                 BILL OF SALE

For valuable consideration SEQUENOM, INC. ("Seller") sells to PHOENIX LEASING
INCORPORATED ("Buyer"), the property listed on Exhibit A hereof (the "Additional
Equipment").

Seller covenants and warrants that:

(1)  It is the owner of, and has absolute title to, the Additional Equipment
     which is free and clear of all claims, liens and encumbrances.

(2)  It has not made any prior sale, assignment, or transfer of the Additional
     Equipment.

(3)  It has the present right, power, and authority to sell the Additional
     Equipment to Buyer.

(4)  All action has been taken which is required to make this Bill of Sale a
     legal, valid and binding obligation of Seller.

Seller shall forever warrant and defend the sale of the Additional Equipment to
Buyer, its successors and assigns, against any person claiming an interest in
the Additional Equipment.

This Bill of Sale is binding on the successors and assigns of Seller and inures
to the benefit of the successors and assigns of Buyer.

Executed on August 1, 1999

                                        SEQUENOM, INC.

                                        By:  /s/ E. Anderson
                                           ------------------------------------
                                        Name:     Elizabeth Anderson
                                             ----------------------------------
                                        Title:   Finance Mgr.
                                              ---------------------------------
<PAGE>

                         Phoenix Leasing Incorporated
                                Funding Request
                                   Exhibit A


        Lessee: SEQUENOM, INC.
                ----------------------
                11555 SORRENTO VALLEY ROAD

<TABLE>
<CAPTION>
Master Contact:  0135                                                                                 Schedule:  18
               ---------                                                                                        --------

- --------------------------------------------------------------------------------------------------------------------------------
                                                                                                    Total                 Tax Pd
 Item                    Invoice    Description                 Eq    Qty     Serial           Invoic'd $      $ Pd by     Vndr?
 No.     Vendor Name     No.        of Item                     Cd            Number  LOC   Net of Sls Tx       Lessee     (Y/N)
- --------------------------------------------------------------------------------------------------------------------------------
<S>      <C>             <C>        <C>                         <C>   <C>     <C>     <C>   <C>              <C>          <C>
- --------------------------------------------------------------------------------------------------------------------------------
  1      MICRON          4472513    MILLENNIA SYSTEM            1     1                1         1,733.99     1,733.99       N
- --------------------------------------------------------------------------------------------------------------------------------
  2                                 FREIGHT                     27    1                1           104.00       104.00       N
- --------------------------------------------------------------------------------------------------------------------------------
  3                      4464433    MILLENNIA SYSTEM            1     1                1         1,725.00     1,725.00       N
- --------------------------------------------------------------------------------------------------------------------------------
  4                                 FREIGHT                     27    1                1           104.00       104.00       N
- --------------------------------------------------------------------------------------------------------------------------------
  5                      4465333    MILLENNIA SYSTEM            1     1                1         1,725.00     1,725.00       N
- --------------------------------------------------------------------------------------------------------------------------------
  6                                 FREIGHT                     27    1                1           104.00       104.00       N
- --------------------------------------------------------------------------------------------------------------------------------
  7                      4462166    MILLENNIA SYSTEM            1     1                1         1,974.00     1,974.00       N
- --------------------------------------------------------------------------------------------------------------------------------
  8                                 FREIGHT                     27    1                1            54.00        54.00       N
- --------------------------------------------------------------------------------------------------------------------------------
  9      GESIM           R990059    NANO PLOTTER                2     1                1        15,701.95    15,701.95       N
- --------------------------------------------------------------------------------------------------------------------------------
  10                                video monitor 12"           2     1                1           456.82       456.82       N
- --------------------------------------------------------------------------------------------------------------------------------
  11                                pkging for transportation   27    1                1           122.56       122.56       N
- --------------------------------------------------------------------------------------------------------------------------------
  12                     R990058    NANO PLOTTER                2     1                1        15,701.95    15,701.95       N
- --------------------------------------------------------------------------------------------------------------------------------
  13                                video monitor 12"           2     1                1           456.82       456.82       N
- --------------------------------------------------------------------------------------------------------------------------------
  14                                pkging for transportation   27    1                1           122.56       122.56       N
- --------------------------------------------------------------------------------------------------------------------------------
  15                     R990018    1-CHANNEL NANO PLOTTER      2     1                1        19,968.54    19,968.54       N
- --------------------------------------------------------------------------------------------------------------------------------
  16                                pkging for transportation   27    1                1           394.80       394.80       N
- --------------------------------------------------------------------------------------------------------------------------------
  17
- --------------------------------------------------------------------------------------------------------------------------------

<CAPTION>

- ------------------------------------------------------------------
                                            No entry required
                                       ---------------------------
 Item                 Transact          Net $ Due        Net $ Due
 No.       Chk No.        Date             Lessee           Vendor
- ------------------------------------------------------------------
<S>        <C>        <C>              <C>              <C>
  1        5522        6/30/99         $ 1,733.99       $     0.00
- ------------------------------------------------------------------
  2        5522        6/30/99         $   104.00       $     0.00
- ------------------------------------------------------------------
  3        5522        6/30/99         $ 1,725.00       $     0.00
- ------------------------------------------------------------------
  4        5522        6/30/99         $   104.00       $     0.00
- ------------------------------------------------------------------
  5        5522        6/30/99         $ 1,725.00       $     0.00
- ------------------------------------------------------------------
  6        5522        6/30/99         $   104.00       $     0.00
- ------------------------------------------------------------------
  7        5522        6/30/99         $ 1,974.00       $     0.00
- ------------------------------------------------------------------
  8        5522        6/30/99         $    54.00       $     0.00
- ------------------------------------------------------------------
  9        WIRE        7/21/99         $15,701.95       $     0.00
- ------------------------------------------------------------------
  10       WIRE        7/21/99         $   456.82       $     0.00
- ------------------------------------------------------------------
  11       WIRE        7/21/99         $   122.56       $     0.00
- ------------------------------------------------------------------
  12       WIRE        7/21/99         $15,701.95       $     0.00
- ------------------------------------------------------------------
  13       WIRE        7/21/99         $   456.82       $     0.00
- ------------------------------------------------------------------
  14       WIRE        7/21/99         $   122.56       $     0.00
- ------------------------------------------------------------------
  15       WIRE        7/21/99         $19,968.54       $     0.00
- ------------------------------------------------------------------
  16       WIRE        7/21/99         $   394.80       $     0.00
- ------------------------------------------------------------------
  17                                   $     0.00       $     0.00
- ------------------------------------------------------------------
        TOTAL AMOUNT DUE TO LESSEE     $60,449.99
                                       ---------------------------
                       TOTAL AMOUNT DUE TO VENDOR       $     0.00
                                                        ----------
                                       TOTAL DRAW       $60,449.99
                                                        ----------
</TABLE>


          Lessee Signature: /s/ E. Anderson     Date: 8/2/99
                            ---------------           -------

                                  Page 1 of 1

<PAGE>

                             OFFICER'S CERTIFICATE
                             ---------------------

The undersigned, Elizabeth Anderson, hereby certifies that:

i)    I am the Treasurer Finance Mgr. Officer of SEQUENOM, INC., a Delaware
      corporation;

ii)   as such officer, I am familiar with the terms and conditions of that
      certain Master Equipment Lease dated as of February 5, 1998 as amended by
      Amendment No. 2 (the "Lease") between SEQUENOM, INC. ("Lessee") and
      PHOENIX LEASING INCORPORATED ("Lessor");

iii)  this certificate is delivered in connection with the leasing of certain
      equipment under an Additional Commitment Schedule with Lessor, the
      equipment is described in the Additional Commitment Schedule and the
      equipment is free and clear from any and all liens, charges, security
      interests or other encumbrances which may affect Lessor's right, title or
      interest in and to the equipment;

iv)   there has been no material adverse change in the financial condition of
      Lessee from the date of its most recent financial statements, true copies
      of which have been delivered to Lessor; and

v)    no event which, with the giving of notice or passage of time, or both,
      could become an Event of Default under the Lease has occurred and is
      continuing.

(vi)  Lessee is performing according to Lessee's business plan described in
      Section 3 of the Lease, a true copy of which business plan has been
      delivered to Lessor;

(vii) the representations and warranties in Section 5 of the Lease are true and
      correct as of the date hereof.

IN WITNESS WHEREOF, I hereby execute this certificate on this 2 day of August,
1999.

                                                       /s/ E. Anderson
                                                    ----------------------------

<PAGE>

                                                                   EXHIBIT 10.46

                            CUMMINGS PROPERTIES LLC
                                 STANDARD FORM
                                COMMERCIAL LEASE

  In consideration of the covenants herein contained, Cummings Properties, LLC,
hereinafter called LESSOR, does hereby lease to Sequenom, Inc. (a DE Corp.),
11555 Sorrento Valley Road, San Diego, CA 92121-1331 hereinafter called LESSEE,
the following described premises, hereinafter called the leased premises:
approximately 3,292 square feet (including 15% common area) at 142-F North Road,
Suite 150, Sudbury, MA  01776.

  TO HAVE AND HOLD the leased premises for a term of three (3) years commencing
at noon on August 1, 1999 and ending at noon on July 30, 2002 unless sooner
terminated as herein provided.  LESSOR and LESSEE now covenant and agree that
the following terms and conditions shall govern this lease during the term
hereof and for such further time as LESSEE shall hold the leased premises.

  1.  RENT.  LESSEE shall pay to LESSOR base rent at the rate of forty nine
thousand two hundred fifteen (49,215.00) U.S. dollars per year, drawn on a U.S.
bank, payable in advance in monthly installments of $4,101.25 on the first day
in each calendar month in advance, the first monthly payment to be made upon
LESSEE's execution of this lease, including payment in advance of appropriate
fractions of a monthly payment for any portion of a month at the commencement or
end of said lease term.  All payments shall be made to LESSOR or agent at 200
West Cummings Park, Woburn, Massachusetts 01801, or at such other place as
LESSOR shall from time to time in writing designate.  If the "Cost of Living"
has increased as shown by the Consumer Price Index (Boston, Massachusetts, all
items, all urban consumers), U.S. Bureau of Labor Statistics, the amount of base
rent due during each calendar year of this lease and any extensions thereof
shall be annually adjusted in proportion to any increase in the Index.  All such
adjustments shall take place with the rent due on January 1 of each year during
the lease term.  The base month from determine the amount of each increase in
the Index shall be January 1999, which figure shall be compared with the figure
for November 1999, and each November thereafter to determine the percentage
increase (if any) in the base rent to be paid during the following calendar
year.  In the event that the Consumer Price Index as presently computed is
discontinued as a measure of "Cost of Living" changes, any adjustment shall then
be made on the basis of a comparable index then in general use.

  2.  SECURITY DEPOSIT.  LESSEE shall pay to LESSOR a security deposit in the
amount of eight thousand two hundred (8,200.00) U.S. dollars upon the execution
of this lease by LESSEE, which shall be held as security for LESSEE's
performance as herein provided and refunded to LESSEE without interest at the
end of this lease, subject to LESSEE's satisfactory compliance with the
conditions hereof.  LESSEE may not apply the security deposit to payment of the
last month's rent.  In the event of any default or breach of this lease by
LESSEE, LESSOR may immediately apply the security deposit first to any
unamortized improvements completed for LESSEE's occupancy, then to offset any
outstanding invoice or other payment due to LESSOR, with the balance applied to
outstanding rent.  If all or any portion of the security deposit is applied to
cure a default or breach during the term of the lease, LESSEE shall be
<PAGE>

responsible for restoring said deposit forthwith, and failure to do so shall be
considered a substantial default under the lease.  LESSEE's failure to remit the
full security deposit or any portion thereof when due shall also constitute a
substantial lease default.  Until such time as LESSEE pays the security deposit
and first month's rent, LESSOR may declare this lease null and void for failure
of consideration.

  3.  USE OF PREMISES.  LESSEE shall use the leased premises only for the
purpose of executive and administrative offices, sales, and customer support
services.

  4.  ADDITIONAL RENT.  LESSEE shall pay to LESSOR as additional rent a
proportionate share (based on square footage leased by LESSEE as compared with
the total leaseable square footage of the building of which the leased premises
are a part) of any increase in the real estate taxes levied against the land and
building of which the leased premises are a part (hereinafter called the
building), whether such increase is caused by an increase in the tax rate, or
the assessment on the property, or a change in the method of determining real
estate taxes.  LESSEE shall make payment within thirty (30) days of written
notice from LESSOR that such increased taxes are payable, and any additional
rent shall be prorated should the lease terminate before the end of any tax
year.  The base from which to determine the amount of any increase in taxes
shall be the rate and the assessment in effect as of July 1, 1999.

  5.  UTILITIES.  LESSOR shall provide equipment per LESSOR's building standard
specifications to heat the leased premises in season and to cool all office
areas between May 1 and November 1.  LESSEE shall pay all charges for utilities
used on the leased premises, including electricity, gas, oil, water and sewer.
LESSEE shall pay the utility provider or LESSOR, as applicable, for all such
utility charges as determined by separate meters serving the leased premises
and/or as a proportionate share of the utility charges for the building if not
separately metered.  LESSEE shall also pay LESSOR a proportionate share of any
other fees and charges relating in any way to utility use at the building.  No
plumbing, construction or electrical work of any type shall be done without
LESSOR's prior written approval and LESSEE obtaining the appropriate municipal
permit.

  6.  COMPLIANCE WITH LAWS.  LESSEE acknowledges that no trade, occupation,
activity or work shall be conducted in the leased premises or use made thereof
which may be unlawful, improper, noisy, offensive, or contrary to any applicable
statute, regulation, ordinance or bylaw.  LESSEE shall keep all employees
working in the leased premises covered by Worker's Compensation Insurance and
shall obtain any licenses and permits necessary for LESSEE's occupancy.  LESSEE
shall be responsible for causing the leased premises and any alterations by
LESSEE which are allowed hereunder to be in full compliance with any applicable
statute, regulation, ordinance or bylaw.

  7.  FIRE, CASUALTY, EMINENT DOMAIN.  Should a substantial portion of the
leased premises, or of the property of which they are a part, be substantially
damaged by fire or other casualty, or be taken by eminent domain, LESSOR may
elect to terminate this lease.  When such fire, casualty, or taking renders the
leased premises substantially unsuitable for their intended use, a just and
proportionate abatement of rent shall be made, and LESSEE may elect to terminate
this lease it:  (a) LESSOR fails to give written notice within thirty (30) days
of intention to restore the leased premises, or (b) LESSOR fails to restore the
leased premises to a

                                      -2-
<PAGE>

condition substantially suitable for their intended use within ninety (90) days
of said fire, casualty or taking. LESSOR reserves all rights for damages or
injury to the leased premises for any taking by eminent domain, except for
damage to LESSEE's property or equipment.

  8.  FIRE INSURANCE.  LESSEE shall not permit any use of the leased premises
which will adversely affect or make voidable any insurance on the property of
which the leased premises are a part, or on the contents of said property, or
which shall be contrary to any law or regulation from time to time published by
the Insurance Services Office (or successor), local Fire Department, LESSOR's
insurer, or any similar body.  LESSEE shall on demand reimburse LESSOR, and all
other tenants, all extra insurance premiums caused by LESSEE's use of the leased
premises.  LESSEE shall not vacate the leased premises or permit same to be
unoccupied other than during LESSEE's customary non-business days or hours.

  9.  MAINTENANCE OF PREMISES.  LESSOR will be responsible for all structural
maintenance of the leased premises and for the normal daytime maintenance of all
space heating and cooling equipment, sprinklers, doors, locks, plumbing, and
electrical wiring, but specifically excluding damage caused by the careless,
malicious, willful, or negligent acts of LESSEE or others, chemical, water or
corrosion damage from any source, and maintenance of any non "building standard"
leasehold improvements.  LESSEE agrees to maintain at its expense all other
aspects of the leased premises in the same condition as they are at the
commencement of the term or as they may be put in during the term of this lease,
normal wear and tear and damage by fire or other casualty only excepted, and
whenever necessary, to replace light bulbs, plate glass and other glass therein,
acknowledging that the leased premises are now in good order and the light bulbs
and glass whole.  LESSEE will properly control or vent all solvents, degreasers,
smoke, odors, etc. and shall not cause the area surrounding the leased premises
to be in anything other than a neat and clean condition, depositing all waste in
appropriate receptacles.  LESSEE shall be solely responsible for any damage to
plumbing equipment, sanitary lines, or any other portion of the building which
results from the discharge or use of any acid or corrosive substance by LESSEE.
LESSEE shall not permit the leased premises to be overloaded, damaged, stripped
or defaced, nor suffer any waste, and will not keep animals within the leased
premises.  If the leased premises include any wooden mezzanine type space, the
floor capacity of such space is suitable only for office use, light storage or
assembly work.  LESSEE will protect any carpet with plastic or masonite chair
pads under any rolling chairs.  Unless heat is provided at LESSOR's expense,
LESSEE shall maintain sufficient heat to prevent freezing of pipes or other
damage.  Any increase in air conditioning equipment or electrical capacity or
any installation or maintenance of equipment which is necessitated try some
specific aspect of LESSEE's use of the leased premises shall be LESSEE's sole
responsibility, at LESSEE's expense and subject to LESSOR's prior written
consent.  All maintenance provided by LESSOR shall be during LESSOR's normal
business hours.

  10.  ALTERATIONS.  LESSEE shall not make structural alterations or additions
of any kind to the leased premises, but may make nonstructural alterations
provided LESSOR consents thereto in writing.  All such allowed alterations shall
be at LESSEE's expense and shall conform with LESSOR's construction
specifications.  If LESSOR or LESSOR's agent provides any services or
maintenance for LESSEE in connection with such alterations or otherwise under
this lease, any just invoice will be promptly paid.  LESSEE shall not permit any
mechanics' liens, or similar liens, to remain upon the leased premises in
connection with work of any character

                                      -3-
<PAGE>

performed or claimed to have been performed at the direction of LESSEE and shall
cause any such lien to be released or removed forthwith without cost to LESSOR.
Any alterations or additions shall become part of the leased premises and the
property of LESSOR. Any alterations completed by LESSOR or LESSEE shall be
LESSOR's "building standard" unless noted otherwise. LESSOR shall have the right
at any time to change the arrangement of parking areas, stairs, walkways or
other common areas of the building.

  11.  ASSIGNMENT OR SUBLEASING.  LESSEE shall not assign this lease or sublet
or allow any other firm or individual to occupy the whole or any part of the
leased premises without LESSOR's prior written consent.  Notwithstanding such
assignment or subleasing, LESSEE and GUARANTOR shall remain liable to LESSOR for
the payment of all rent and for the full performance of the covenants and
conditions of this lease.  LESSEE shall pay LESSOR promptly for legal and
administrative expenses incurred by LESSOR in connection with any consent
requested hereunder by LESSEE.

  12.  SUBORDINATION.  This lease shall be subject and subordinate to any and
all mortgages and other instruments in the nature of a mortgage, now or at any
time hereafter, and LESSEE shall, when requested, promptly execute and deliver
such written instruments as shall be necessary to show the subordination of this
lease to said mortgages or other such instruments in the nature of a mortgage.

  13.  LESSOR'S ACCESS.  LESSOR or agents of LESSOR may at any reasonable time
enter to view the leased premises, to make repairs and alterations as LESSOR
should elect to do for the leased premises, the common areas or any other
portions of the building, to make repairs which LESSEE is required but has
failed to do, and to show the leased premises to others.

  14.  SNOW REMOVAL.  The plowing of snow from all roadways and unobstructed
parking areas shall be at the sole expense of LESSOR.  The control of snow and
ice on all walkways, steps and loading areas serving the leased premises and all
other areas not readily accessible to plows shall be the sole responsibility of
LESSOR except for claims arising out of LESSOR's negligence.  Notwithstanding
the foregoing, however, LESSEE shall hold LESSOR and OWNER harmless from any and
all claims by LESSEE's agents, representatives, employees, callers or invitees
for damage or personal injury resulting in any way from snow or ice on any area
serving the leased premises.

  15.  ACCESS AND PARKING.  LESSEE shall have the right without additional
charge to use parking facilities provided for the leased premises in common with
others entitled to the use thereof.  Said parking areas plus any stairs,
corridors, walkways, elevators or other common areas (hereinafter collectively
called the common areas) shall in all cases be considered a part of the leased
premises when they are used by LESSEE or LESSEE's employees, agents, callers or
invitees.  LESSEE will not obstruct in any manner any portion of the building or
the walkways or approaches to the building, and will conform to all rules and
regulations now or hereafter made by LESSOR for parking, and for the care, use,
or alteration of the building, its facilities and approaches.  LESSEE further
warrants that LESSEE will not permit any employee or visitor to violate this or
any other covenant or obligation of LESSEE.  No unattended parking will be
permitted between 7:00 PM and 7:00 AM without LESSOR's prior written approval,
and from December 1 through March 31 annually, such parking shall be permitted
only in those areas

                                      -4-
<PAGE>

specifically designated for assigned overnight parking. Unregistered or disabled
vehicles, or storage trailers of any type, may not be parked at any time. LESSOR
may tow, at LESSEE's sole risk and expense, any misparked vehicle belonging to
LESSEE or LESSEE's agents, employees, invitees or callers, at any time. LESSOR
shall not be responsible for providing any security services for the leased
premises.

  16.  LIABILITY.  LESSEE shall be solely responsible as between LESSOR and
LESSEE for deaths or personal injuries to all persons whomsoever occurring in or
on the leased premises (including any common areas that are considered part of
the leased premises hereunder) from whatever cause arising, and damage to
property to whomsoever belonging arising out of the use, control, condition or
occupation of the leased premises by LESSEE; and LESSEE agrees to indemnity and
save harmless LESSOR and OWNER from any and all liability, including but not
limited to costs, expenses, damages, causes of action, claims, judgments and
attorney's fees caused by or in any way growing out of any matters aforesaid,
except for death, personal injuries or property damage directly resulting from
the sole negligence of LESSOR.

  17.  INSURANCE.  LESSEE will secure and carry at its own expense a commercial
general liability policy insuring LESSEE, LESSOR and OWNER against any claims
based on bodily injury (including death) or property damage arising out of the
condition of the leased premises (including any common areas that are considered
part of the leased premises hereunder) or their use by LESSEE, such policy to
insure LESSEE, LESSOR and OWNER against any claim up to One Million (1,000,000)
Dollars in the case of any one accident involving bodily injury (including
death), and up to One Million (1,000,000) Dollars against any claim for damage
to property.  LESSOR and OWNER shall be included in each such policy as
additional insureds using ISO Form CG 20 26 11 85 or some other form approved by
LESSOR.  LESSEE will file with LESSOR prior to occupancy certificates and any
applicable riders or endorsements showing that such insurance is in force, and
thereafter will file renewal certificates prior to the expiration of any such
policies.  All such insurance certificates shall provide that such policies
shall not be cancelled without at least ten (10) days prior written notice to
each insured.  In the event LESSEE shall fail to provide or maintain such
insurance at any time during the term of this lease, then LESSOR may elect to
contract for such insurance at LESSEE's expense.

  18.  SIGNS.  LESSOR authorizes, and LESSEE at LESSEE's expense agrees to erect
promptly upon commencement of this lease, signage for the leased premises in
accordance with LESSOR's building standards for style, size, location, etc.
LESSEE shall obtain the prior written consent of LESSOR before erecting a sign
on the leased premises, which consent shall include approval as to size,
wording, design and location.  LESSOR may remove and dispose of any sign not
approved, and or displayed in conformance with this lease.

  19.  BROKERAGE.  LESSEE warrants and represents to LESSOR that LESSEE has
dealt with no broker or third person with respect to this lease except Tad Lee
of Meredith & Grew, and LESSEE agrees to indemnity LESSOR against any brokerage
claims arising by virtue of this lease.  LESSOR warrants and represents to
LESSEE that LESSOR has employed no exclusive broker or agent in connection with
the letting of the leased premises.

  20.  DEFAULT AND ACCELERATION OF RENT.  In the event that:  (a) any assignment
for the benefit of creditors, trust mortgage, receivership or other insolvency
proceeding shall be

                                      -5-
<PAGE>

made or instituted with respect to LESSEE or LESSEE's property; (b) LESSEE shall
default in the observance or performance of any of LESSEE's covenants,
agreements, or obligations hereunder, other than substantial monetary payments
as provided below, and such default shall not be corrected within ten (10) days
after written notice thereof; or (c) LESSEE vacates the leased premises, then
LESSOR shall have the right thereafter, while such default continues and without
demand or further notice, to re-enter and take possession of the leased
premises, to declare the term of this lease ended, and to remove LESSEE's
effects, without being guilty of any manner of trespass, and without prejudice
to any remedies which might be otherwise used for arrears of rent or other
default or breach of the lease. If LESSEE shall default in the payment of the
security deposit, rent, taxes, substantial invoice from LESSOR or LESSOR's agent
for goods and/or services or other sum herein specified, and such default shall
continue for ten (10) days after written notice hereof, and, because both
parties agree that nonpayment of said sums when due is a substantial breach of
the lease, and, because the payment of rent in monthly installments is for the
sole benefit and convenience of LESSEE, then in addition to the foregoing
remedies the entire balance of rent which is due hereunder shall become
immediately due and payable as liquidated damages. LESSOR, without being under
any obligation to do so and without thereby waiving any default, may remedy same
for the account and at the expense of LESSEE, if LESSOR pays or incurs any
obligations for the payment of money in connection therewith, such sums paid or
obligations incurred plus interest and costs, shall be paid to LESSOR by LESSEE
as additional rent. Any sums received by LESSOR from or on behalf of LESSEE at
any time shall be applied first to any unamortized improvements completed for
LESSEE's occupancy, then to offset any outstanding invoice or other payment due
to LESSOR, with the balance applied to outstanding rent. LESSEE agrees to pay
reasonable attorney's fees and/or administrative costs incurred by LESSOR in
enforcing any or all obligations of LESSEE under this lease at any time. LESSEE
shall pay LESSOR interest at the rate of eighteen (18) percent per annum on any
payment from LESSEE to LESSOR which is past due.

  21.  NOTICE.  Any notice from LESSOR to LESSEE relating to the leased premises
or to the occupancy thereof shall be deemed duty served when left at the leased
premises addressed to LESSEE, or served by constable, or sent to the leased
promises by certified mail, return receipt requested, postage prepaid, addressed
to LESSEE.  Any notice from LESSEE to LESSOR relating to the leased premises or
to the occupancy thereof shall be deemed duty served when served by constable,
or delivered to LESSOR by certified mail, return receipt requested, postage
prepaid, addressed to LESSOR at 200 West Cummings Park, Woburn, MA 01801 or at
LESSOR's last designated address.  No oral notice or representation shall have
any force or effect.  Time is of the essence in the service of any notice.

  22.  OCCUPANCY.  In the event that LESSEE takes possession of said leased
premises prior to the start of the lease term, LESSEE will perform and observe
all of LESSEE's covenants from the date upon which LESSEE takes possession
except the obligation for the payment of extra rent for any period of less than
one month.  LESSEE shall not remove LESSEE's goods or property from the leased
premises other than in the ordinary and usual course of business, without having
first paid and satisfied LESSOR for all rent which may become due during the
entire term of this lease.  LESSOR may require LESSEE to relocate to another
similar facility upon prior written notice to LESSEE and on terms comparable to
those herein.  In the event that LESSEE continues to occupy or control all or
any part of the leased premises after the agreed termination of this lease
without the written permission of LESSOR, then LESSEE shall be

                                      -6-
<PAGE>

liable to LESSOR for any and all loss, damages or expenses incurred by LESSOR,
and all other terms of this lease shall continue to apply except that rent shall
be due in full monthly installments at a rate of one hundred fifty (150) percent
of that which would otherwise be due under this lease, it being understood
between the parties that such extended occupancy is as a tenant at sufferance
and is solely for the benefit and convenience of LESSEE and as such has greater
rental value. LESSEE's control or occupancy of all or any part of the leased
premises beyond noon on the last day of any monthly rental period shall
constitute LESSEE's occupancy for an entire additional month, and increased rent
as provided in this section shall be due and payable immediately in advance.
LESSOR's acceptance of any payments from LESSEE during such extended occupancy
shall not alter LESSEE's status as a tenant at sufferance.

  23.  FIRE PREVENTION.  LESSEE agrees to use every reasonable precaution
against fire and agrees to provide and maintain approved, labeled fire
extinguishers, emergency lighting equipment, and exit signs and complete any
other modifications within the leased premises as required or recommended by the
Insurance Services Office (or successor organization), OSHA, the local Fire
Department, or any similar body.

  24.  OUTSIDE AREA.  Any goods, equipment, or things of any type or description
held or stored in  any common area without LESSOR's prior written consent shall
be deemed abandoned and may be removed by LESSOR at LESSEE's expense without
notice.  LESSEE shall maintain a building standard size dumpster in a location
approved by LESSOR, which dumpster shall be provided and serviced at LESSEE's
expense by whichever disposal firm may from time to time be designated by
LESSOR.  Alternatively, if a shared dumpster or compactor is provided by LESSOR,
LESSEE shall pay its proportionate share of any costs associated therewith.

  25.  ENVIRONMENT.  LESSEE will so conduct and operate the leased premises as
not to interfere in any way with the use and enjoyment of other portions of the
same or neighboring buildings by others by reason of odors, smoke, exhaust,
smells, noise, pets, accumulation of garbage or trash, vermin or other pests, or
otherwise, and will at its expense employ a professional pest control service it
necessary.  LESSEE agrees to maintain efficient and effective devices for
preventing damage to heating equipment from solvents, degreasers, cutting oils,
propellants, etc. which may be present at the leased premises.  No hazardous
materials or wastes shall be stored, disposed of, or allowed to remain at the
leased premises at any time, and LESSEE shall be solely responsible for any and
all corrosion or other damage associated with the use, storage and/or disposal
of same by LESSEE.

  26.  RESPONSIBILITY.  Neither LESSOR nor OWNER shall be held liable to anyone
for loss or damage caused in any way by the use, leakage, seepage or escape of
water from any source, or for the cessation of any service rendered customarily
to said premises or buildings, or agreed to by the terms of this lease, due to
any accident, the making of repairs, alterations or improvements, labor
difficulties, weather conditions, mechanical breakdowns, trouble or scarcity in
obtaining fuel, electricity, service or supplies from the sources from which
they are usually obtained for said building, or any cause beyond LESSOR's
immediate control.

  27.  SURRENDER.  LESSEE shall at the termination of this lease remove all of
LESSEE's goods and effects from the leased premises.  LESSEE shall deliver to
LESSOR the leased premises and all keys and locks thereto, all fixtures and
equipment connected therewith, and all

                                      -7-
<PAGE>

alterations, additions and improvements made to or upon the leased premises,
whether completed by LESSEE, LESSOR or others, including but not limited to any
offices, partitions, window blinds, floor coverings (including computer floors),
plumbing and plumbing fixtures, air conditioning equipment and ductwork of any
type, exhaust fans or heaters, water coolers, burglar alarms, telephone wiring,
telephone equipment, air or gas distribution piping, compressors, overhead
cranes, hoists, trolleys or conveyors, counters, shelving or signs attached to
walls or floors, all electrical work, including but not limited to lighting
fixtures of any type, wiring, conduit, EMT, transformers, distribution panels,
bus ducts, raceways, outlets and disconnects, and furnishings or equipment which
have been bolted, welded, nailed, screwed, glued or otherwise attached to any
wall, floor, ceiling, roof, pavement or ground, or which have been directly
wired to any portion of the electrical system or which have been plumbed to the
water supply, drainage or venting systems serving the leased premises. LESSEE
shall deliver the leased premises sanitized from any chemicals or other
contaminants, and broom clean and in the same condition as they were at the
commencement of this lease or any prior lease between the parties for the leased
premises, or as they were modified during said term with LESSOR's written
consent, reasonable wear and tear and damage by fire or other casualty only
excepted. In the event of LESSEE's failure to remove any of LESSEE's property
from the leased promises upon termination of the lease, LESSOR is hereby
authorized, without liability to LESSEE for loss or damage thereto, and at the
sole risk of LESSEE, to remove and store any such property at LESSEE's expense,
or to retain same under LESSOR's control, or to sell at public or private sale
(without notice), any or all of the property not so removed and to apply the net
proceeds of such sale to the payment of any sum due hereunder, or to destroy
such abandoned property. In no case shall the leased premises be deemed
surrendered to LESSOR until the termination date provided herein or such other
date as may be specified in a written agreement between the parties,
notwithstanding the delivery of any keys to LESSOR.

  28.  GENERAL.  (a) The invalidity or unenforceability of any provision of this
lease shall not affect or render invalid or unenforceable any other provision
hereof.  (b) The obligations of this lease shall run with the land, and this
lease shall be binding upon and inure to the benefit of the parties hereto and
their respective successors and assigns, except that LESSOR and OWNER shall be
liable only for obligations occurring while lessor, owner, or master lessee of
the premises.  (c) Any action or proceeding arising out of the subject matter of
this lease shall be brought by LESSEE within one year after the cause of action
has occurred and only in a court of the Commonwealth of Massachusetts.  (d) If
LESSOR is acting under or as agent for any trust or corporation, the obligations
of LESSOR shall be binding upon the trust or corporation, but not upon any
trustee, officer, director, shareholder, or beneficiary of the trust or
corporation individually.  (e) If LESSOR is not the owner (OWNER) of the leased
premises, LESSOR represents that said OWNER has agreed to be bound by the terms
of this lease unless LESSEE is in default hereof.  (f) This lease is made and
delivered in the Commonwealth of Massachusetts, and shall be interpreted,
construed, and enforced in accordance with the laws thereof.  (g) This lease was
the result of negotiations between parties of equal bargaining strength, and
when executed by both parties shall constitute the entire agreement between the
parties, superseding all prior oral and written agreements, representations,
statements and negotiations relating in any way to the subject matter herein.
This lease may not be extended or amended except by written agreement signed by
both parties or as otherwise provided herein, and no other subsequent oral or
written representation shall have any effect hereon.  (h) Notwithstanding any
other statements herein, LESSOR makes no warranty, express or implied,
concerning the suitability of the leased

                                      -8-
<PAGE>

premises for LESSEE's intended use. (i) LESSEE agrees that if LESSOR does not
deliver possession of the leased premises as herein provided for any reason,
LESSOR shall not be liable for any damages to LESSEE for such failure, but
LESSOR agrees to use reasonable efforts to deliver possession to LESSEE at the
earliest possible date. A proportionate abatement of rent, excluding the cost of
any amortized improvements to the leased premises, for such time as LESSEE may
be deprived of possession of the leased premises, except where a delay in
delivery is caused in any way by LESSEE, shall be LESSEE's sole remedy. (j)
Neither the submission of this lease form, nor the prospective acceptance of the
security deposit and/or rent shall constitute a reservation of or option for the
leased premises, or an offer to lease, it being expressly understood and agreed
that this lease shall not bind either party in any manner whatsoever until it
has been executed by both parties. (k) LESSEE shall not be entitled to exercise
any option contained herein if LESSEE is at that time in default of any terms or
conditions hereof. (l) Except as otherwise provided herein, LESSOR, OWNER and
LESSEE shall not be liable for any special, incidental, indirect or
consequential damages, including but not limited to lost profits or loss of
business, arising out of or in any manner connected with performance or
nonperformance under this lease, even if any party has knowledge of the
possibility of such damages. (m) The headings in this lease are for convenience
only and shall not be considered part of the terms hereof. (n) No endorsement by
LESSEE on any check shall bind LESSOR in any way. (o) LESSOR and LESSEE hereby
waive any and all rights to a jury trial in any proceeding in any way arising
out of this lease.

  29.  SECURITY AGREEMENT.  This Paragraph Does Not Apply.

  30.  WAIVERS, ETC.  No consent or waiver, express or implied, by LESSOR, to or
of any breach of any covenant, condition or duty of LESSEE shall be construed as
a consent or waiver to or of any other breach of the same or any other covenant,
condition or duty.  If LESSEE is several persons, several corporations or a
partnership, LESSEE's obligations are joint or partnership and also several.
Unless repugnant to the context, "LESSOR" and "LESSEE" mean the person or
persons, natural or corporate, named above as LESSOR and as LESSEE respectively,
and their respective heirs, executors, administrators, successors and assigns.

  31.  AUTOMATIC FIVE-YEAR EXTENSIONS.  This lease, including all terms,
conditions, escalations, etc. shall be automatically extended for additional
successive periods of five (5) years each unless LESSOR or LESSEE shall serve
written notice, either party to the other, of either party's desire not to so
extend the lease.  The time for serving such written notice shall be not more
than twelve (12) months or less than four (4) months prior to the expiration of
the current lease period.  Time is of the essence.

  32.  ADDITIONAL PROVISIONS.  (Continued on attached rider(s) if necessary.)

                                      -9-
<PAGE>

                             - SEE ATTACHED RIDER -

  IN WITNESS WHEREOF, LESSOR and LESSEE have hereunto set their hands and common
seals and intend to be legally bound hereby this 24th day of June, 1999.

LESSOR:  CUMMINGS PROPERTIES LLC  LESSEE:  SEQUENOM, INC.

By:  /s/ illegible                    By:  /s/ Hubert Koster   6/24/99
     ---------------------------           ---------------------------
     Executive Vice President              President & CEO

                                    GUARANTY

  IN CONSIDERATION of the making of the above lease by Cummings Properties LLC
with Sequenom, Inc. at the request of the undersigned and in reliance on this
guaranty, the undersigned (GUARANTOR) hereby personally guarantees the prompt
payment of rent by LESSEE and the performance by LESSEE of all terms,
conditions, covenants and agreements of the lease, any amendments thereto and
any extensions or assignments thereof, and the undersigned promises to pay all
expenses, including reasonable attorney's fees, incurred by LESSOR in exercising
all obligations of LESSEE under the lease or incurred by LESSOR in enforcing
this guaranty.  LESSOR's consent to any assignments, subleases, amendments and
extensions by LESSEE or to any compromise or release of LESSEE's liability
hereunder, with or without notice to the undersigned, or LESSOR's failure to
notify the undersigned of any default and/or reinstatement of the lease by
LESSEE, shall not relieve the undersigned from liability as GUARANTOR.

  IN WITNESS WHEREOF, the undersigned GUARANTOR has hereunto set his/her/its
hand and common seal intending to be legally bound hereby as of this __ day of
________, ____.

                                      -10-
<PAGE>

                                                                    990341-DJC-3

                            CUMMINGS PROPERTIES, LLC
                                 STANDARD FORM
                                 RIDER TO LEASE

The following additional provisions are incorporated into and made a part of the
attached lease:

A.   * LESSOR, at LESSOR's cost, shall modify the leased premises according to a
     mutually agreed upon plan attached hereto before or about the time LESSEE
     takes possession of the leased premises.

B.   * LESSOR, if requested to do so by LESSEE, and at LESSEE's sole expense,
     agrees to complete certain improvements and alterations necessitated by
     LESSEE's use of the leased premises according to a plan to be mutually
     agreed upon by both parties.  These alterations shall be considered
     "nonbuilding standard" for maintenance purposes pursuant to Section 9 of
     the lease.

C.   * The parties acknowledge and agree that, as of the execution of this
     lease, the leased premises have not been demised.  Accordingly, upon
     completion of the modifications provided for herein, LESSOR shall carefully
     measure the entire leased premises, and if the size including common area
     does not equal the total number of square feet set forth in the initial
     paragraph of this lease, LESSOR shall notify LESSEE in writing of the
     actual revised square footage and the corresponding increase or decrease in
     rent, based on the same rate per square foot used in this lease.

D.   * In the event that LESSOR is unable to obtain a building permit for the
     modifications at the leased premises for the purposes set forth in Section
     3 above, LESSOR shall have the right, at its sole expense, to appeal any
     such decision.  If LESSOR declines to prosecute said appeal or if any such
     decision is upheld after all applicable appeals have been exhausted, then
     LESSEE may cancel this lease by serving LESSOR with 30 days prior written
     notice to that effect, and neither party shall have any further obligation
     to the other.  Cancellation of the lease shall be LESSEE's exclusive remedy
     for any failure by LESSOR to obtain a building permit or otherwise in
     connection with this paragraph.

E.   With reference to Section 25 above, no hazardous materials or hazardous
     wastes shall be used, processed, stored, or disposed of in any manner or
     form within the leased premises or any extension thereof in violation of
     any applicable local, state, or federal law, rule or regulation.  In
     addition, any and all hazardous materials and hazardous waste shall be
     disposed of in containers for off-site disposal, and shall not be disposed
     of on-site through the plumbing system or in any other manner.  LESSEE
     shall be solely responsible for and shall indemnify and hold LESSOR
     harmless from any and all liability, damage or personal injury associated
     with any use, processing, storage, or disposal of such materials.

F.   * As of the termination date of this lease, LESSEE, at LESSEE's sole
     expense, shall return the leased premises free from any and all hazardous
     materials, hazardous wastes, biological, radiological, chemical or other
     contamination or any other materials that are in
<PAGE>

     any way harmful to anyone, and shall be solely responsible for remedying
     any and all damage, removing any and all contamination, and properly
     disposing of any hazardous materials, hazardous wastes and contamination.
     In addition, LESSEE, at LESSEE's sole expense, shall engage an independent
     and accredited industrial hygiene consultant to certify that as of the
     termination date of this lease, the entire leased premises and any
     extension thereof utilized in any way by LESSEE is free from any
     biological, radiological, chemical or other contamination and is in no way
     damaged as a result of LESSEE's use of the premises. Said certification
     shall also specify that the premises are then fully suitable for
     unrestricted, unconditional future use and occupation by others. Time is of
     the essence.

G.   With respect to any condition existing prior to the commencement of
     LESSEE's occupancy under this lease, LESSOR shall hold LESSEE harmless from
     any and all suits, judgments, or liabilities, for any "release," as defined
     in Section 101(22) of the Comprehensive Environmental Response,
     Compensation and Liability Act of 1980, as amended ("CERCLA"), of any
     "hazardous substance" as defined in Section 101 (14) of CERCLA, or any
     petroleum (including crude oil or any fraction thereof) as a result of any
     activity on the property of which the leased premises are a part occurring
     prior to LESSEE's occupancy and not caused by LESSEE.

H.   During the initial term of this lease, LESSEE shall have the one-time right
     of first lease of approximately 1,000 square feet of currently vacant
     adjacent space at 142 North Road at LESSOR's then current published rental
     rate for said space as it becomes available for lease directly from LESSOR,
     following its next leasing to a third party, subject to the right of said
     third party to extend or otherwise renegotiate its lease.  LESSEE shall
     have 48 hours from receipt of notice from LESSOR of said availability to
     execute LESSOR's then current standard form lease or amendment to lease for
     said additional space.  If LESSOR fails to notify LESSEE of the
     availability of said space and leases said space to others, and if LESSEE
     notifies LESSOR of its desire to lease said space and immediately executes
     LESSOR's then current standard form lease or amendment to lease for said
     space, LESSOR shall then have 60 days to relocate the other party.  If
     LESSOR fails to relocate the other party within said 60 days and execute
     the new lease or amendment to lease with LESSEE, then LESSEE may elect, by
     serving LESSOR written notice within 30 days after expiration of the
     relocation period, to occupy a similar amount of additional space elsewhere
     in the building on a no-charge basis until such time as LESSOR delivers
     possession of said space.  This shall be LESSEE's exclusive remedy for any
     failure by LESSOR to deliver possession of said space or any breach by
     LESSOR of the provisions of this paragraph.  Time is of the essence.
<PAGE>

                                    DIAGRAM



                                    /s/  illegible
                              -------------------------------
                                       (Signature)
<PAGE>

                            CUMMINGS PROPERTIES, LLC
                                 STANDARD FORM

                             AMENDMENT TO LEASE #1

  In connection with a lease currently in effect between the parties at 142 F
North Road, Suite 150, Sudbury, Massachusetts, executed on June 24, 1999 and
terminating July 30, 2002 and in consideration of the mutual benefits to be
derived herefrom, Cummings Properties, LLC, LESSOR and Sequenom, Inc.  LESSEE
hereby agree to amend said lease as follows:

1.   The Common area of the portion of the building that serves the leased
     premises is hereby changed from 15 percent to 13.1 percent of the building.

2.   The size of the leased premises is hereby decreased from 3,292 square feet
     (including 15% common area) to 3,258 square feet (including 13.1% common
     area), as a result of the above change in the common area and the
     remeasuring of the leased premises as provided in the Rider to Lease,
     Paragraph C.

3.   LESSOR, at LESSEE's sole expense, shall complete alterations and
     improvements within the leased premises in accordance with the mutually
     agreed upon plan and Additional Work Authorizations attached hereto.
     LESSOR shall amortize the agreed charge of $9,324, without interest, for
     said modifications in the additional rent provided below.


  This amendment shall not bind either party in any manner until it has been
executed by both parties.  All other terms, conditions and covenants of the
present lease shall continue to apply except that* adjusted base rent shall be
increased by $2,688.50 annually, from a total of $49,215.00 to a new annual
total of $51,903.50 or $4,325.29 per month.  Annual base rent for purposes of
computing any future escalations thereon shall be $51,903.50.  This amendment
shall be effective August 1, 1999 and shall continue through the balance of the
lease and any extensions thereof unless further modified by written
amendment(s).

*effective September 1, 1999

  In witness whereof, LESSOR and LESSEE have hereunto set their hands and common
seals this 2nd day of September, 1999.

<TABLE>
<CAPTION>
LESSOR:  CUMMINGS PROPERTIES, LLC                                  LESSEE:  SEQUENOM, INC.
<S>                                                                <C>
By:  /s/  ILLEGIBLE                                                By:  /s/  ILLEGIBLE
   --------------------------------------------                        -----------------------------------------
                                             Executive Vice President
</TABLE>
<PAGE>

                         ADDITIONAL WORK AUTHORIZATION
                       ATLANTIC BOSTON CONSTRUCTION, INC.
                    200 WEST CUMMINS PARK, WOBURN, MA  01801
                        781-935-8000--fax  781-935-1990

<TABLE>
<S>                                                             <C>              <C>           <C>
- ---------------------------------------------------------------------------------------------------------------
CUSTOMER NAME                                                                    DATE          ORIGINATOR
Sequenom                                                                         8/23/99       DJC/MAA
- ---------------------------------------------------------------------------------------------------------------
STREET                                                          CITY             STATE         ZIP CODE
   142 - F North Rd., Suite 150                                 Sudbury          MA            01776
- ---------------------------------------------------------------------------------------------------------------
ATTENTION                                                       PHONE            FAX
Dan Little
- ---------------------------------------------------------------------------------------------------------------
</TABLE>
PROVIDE LABOR AND MATERIALS TO EXECUTE THE FOLLOWING SCOPE OF WORK:

   See attached AWA plan dated 8/5/99

   1. Remove existing carpet and install approx. 1520 SF of CPL standard VCT in
      customers lab and demonstration area.

                               PRICE:      $4,134.00
         Less CPL contribution (50%):      $2,067.00
                                           ---------
                         TOTAL PRICE:      $2,067.00

 .  No representation is made as to the suitability of above work for Customer's
   use of occupancy. IF DIFFERENT THAN STATED IN LEASE (INITIAL) 9/2/9

 .  Customer to remove furniture and equipment from the work area.

 .  Customer acknowledges that the above work or revisions from previously
   approved plans may cause a delay beyond any prior scheduled completion date.

 .  This quote is valid for 30 days from the date of issue. If space is
   unoccupied on date of issue, prices may increase after occupancy. Above work
   is to be accomplished during normal working hours or during prearranged
   overtime at additional expense. Contract price includes sales tax.

 .  AUTHORIZED IN LEASE TERM (INITIAL) 9/2/9

 .  Customer acknowledges that the work described herein shall be considered
   nonbuilding standard under the terms of the lease and shall be maintained by
   Customer following installation, unless otherwise noted.


ACCEPTED BY:      /s/ Delbert F. Foit       DATE:   9/2/99
             ---------------------------         -------------

      PRINTED NAME:      DELBERT F. FOIT                TITLE:     Illegible
                   --------------------------------             ----------------
<TABLE>
<S>                      <C>                    <C>       <C>           <C>         <C>                             <C>
- -----------------------------------------------------------------------------------------------------------------------------
FOR OFFICE USE ONLY      Design/Construction    INITIAL   Supervisor    INITIAL     LESSEE Cert of Insurance and     Initial
                         Approval                    JT   Approval           SF     Endorsement on file                   SF
- -----------------------------------------------------------------------------------------------------------------------------
</TABLE>
<PAGE>

                         ADDITIONAL WORK AUTHORIZATION
                       ATLANTIC BOSTON CONSTRUCTION, INC.
                    200 WEST CUMMINS PARK, WOBURN, MA  01801
                        781-935-8000--fax  781-935-1990

<TABLE>
<S>                                                            <C>         <C>           <C>
- -------------------------------------------------------------------------------------------------------
CUSTOMER NAME                                                               DATE          ORIGINATOR
Sequenom                                                                    8/23/99       DJC/MAA
- -------------------------------------------------------------------------------------------------------
STREET                                                          CITY        STATE         ZIP CODE
   142 - F North Rd., Suite 150                                 Sudbury     MA            01776
- -------------------------------------------------------------------------------------------------------
ATTENTION                                                       PHONE       FAX
Dan Little
- -------------------------------------------------------------------------------------------------------
</TABLE>
PROVIDE LABOR AND MATERIALS TO EXECUTE THE FOLLOWING SCOPE OF WORK:

 See attached AWA plan dated 8/4/99

1.   Install nine 8' long 120V, 20A, ivory plugmold strips at 40" a.f.f., with
     outlets at 6" oc. Work includes dedicated lines from each strip to existing
     electrical panel.
                                      PRICE:                 $1,917.00

2.   Install three 208V, single phase, dedicated electrical outlets NEMA
     configuration to be provided by customer prior to commencement of work.

                                      PRICE:                 $  516.00

3.   Install a 3' x 4' painted plywood phone panel at approved location. Plywood
     to be mounted directly atop existing drywall finish.

                                      PRICE:                 $  100.00


 .    No representation is made as to the suitability of above work for
     Customer's use of occupancy. IF DIFFERENT THAN STATED IN LEASE (INITIALS)
     9/2/99

 .    Customer to remove furniture and equipment from the work area.

 .    Customer acknowledges that the above work or revisions from previously
     approved plans may cause a delay beyond any prior scheduled completion
     date.

 .    This quote is valid for 30 days from the date of issue. If space is
     unoccupied on date of issue, prices may increase after occupancy. Above
     work is to be accomplished during normal working hours or during
     prearranged overtime at additional expense. Contract price includes sales
     tax.

 .    AUTHORIZED IN LEASE TERM (INITIALS) 9/2/99

 .    Customer acknowledges that the work described herein shall be considered
     nonbuilding standard under the terms of the lease and shall be maintained
     by Customer following installation, unless otherwise noted.


ACCEPTED BY:    /s/  Delbert F. Foit             DATE:    9/2/99
             ------------------------------           --------------

                 PRINTED NAME:    DELBERT F. FOIT       TITLE:  Illegible
                               ----------------------         --------------
<TABLE>
<S>                       <C>                 <C>           <C>            <C>         <C>                             <C>
- ---------------------------------------------------------------------------------------------------------------------------------
FOR OFFICE USE ONLY    Design/Construction     INITIALS     Supervisor     INITIALS    LESSEE Cert of Insurance and    INITIALS
                       Approval                      JT      Approval            SF    Endorsement on file                   SF
- ---------------------------------------------------------------------------------------------------------------------------------
</TABLE>
<PAGE>

                         ADDITIONAL WORK AUTHORIZATION
                       ATLANTIC BOSTON CONSTRUCTION, INC.
                    200 WEST CUMMINS PARK, WOBURN, MA  01801
                        781-935-8000--fax  781-935-1990

<TABLE>
<S>                                                        <C>              <C>          <C>
- -----------------------------------------------------------------------------------------------------
CUSTOMER NAME                                                               DATE         ORIGINATOR
Sequenom                                                                    8/23/99      DJC/MAA
- -----------------------------------------------------------------------------------------------------
STREET                                                     CITY             STATE        ZIP CODE
   142 - F North Rd., Suite 150                            Sudbury          MA           01776
- -----------------------------------------------------------------------------------------------------
ATTENTION                                                  PHONE            FAX
Dan Little
- -----------------------------------------------------------------------------------------------------
</TABLE>
PROVIDE LABOR AND MATERIALS TO EXECUTE THE FOLLOWING SCOPE OF WORK:

 See attached AWA plan dated 8/5/99

1.   In the Demonstration Area, install a CPL standard 30" sink base cabinet
     with a 22" x 25" x 10" deep stainless steel sink, goose neck faucet with
     wing blade handle, a 30" postformed countertop and in the adjacent Lab
     install a CPL standard composite utility with faucet, work includes:
     installation of a backflow preventer at the main water supply, a 10 gallon
     electric hot water heater with expansion tank, a15 gallon pH neutralization
     tank, separate vent throughout the roof, and all piping required to connect
     hot, cold, and waste lines to existing services.

                                         PRICE:      $4,080.00

Note:
- ----
     Customer has previously acknowledged that no chemical waste of any kind
     will be disposed of in the above mentioned sink drains.

Option
- ------

     Install a wall mounted eye wash system adjacent to sink and cabinet in the
     Demonstration Area, work includes:  connection to potable cold water supply
     system (not non-potable supply at adjacent sink), connection to vent and
     waste line at adjacent sink, and patching and painting of adjacent dry wall
     partition as necessary.

                                         PRICE:      $784.00

 .    No representation is made as to the suitability of above work for
     Customer's use of occupancy. IF DIFFERENT THAN STATED IN LEASE (INITIALS)
     9/2/99

 .    Customer to remove furniture and equipment from the work area.

 .    Customer acknowledges that the above work or revisions from previously
     approved plans may cause a delay beyond any prior scheduled completion
     date.

 .    This quote is valid for 30 days from the date of issue. If space is
     unoccupied on date of issue, prices may increase after occupancy. Above
     work is to be accomplished during normal working hours or during
     prearranged overtime at additional expense. Contract price includes sales
     tax.

 .    AUTHORIZED IN LEASE TERM (INITIALS) 9/2/99

 .    Customer acknowledges that the work described herein shall be considered
     nonbuilding standard under the terms of the lease and shall be maintained
     by Customer following installation, unless otherwise noted.


ACCEPTED BY:  /s/  Delbert F. Foit            DATE:    9/2/99
            -------------------------------        --------------

            PRINTED NAME:   DELBERT F. FOIT        TITLE:  Illegible
                         ---------------------           --------------

<TABLE>
<S>                     <C>                    <C>         <C>          <C>         <C>                            <C>
- ------------------------------------------------------------------------------------------------------------------------------
FOR OFFICE USE ONLY     Design/Construction    INITIALS    Supervisor   INITIALS    LESSEE Cert of Insurance and    INITIALS
                        Approval                     UT      Approval         SP    Endorsement on file                   SP
- ------------------------------------------------------------------------------------------------------------------------------
</TABLE>
<PAGE>

                                    DIAGRAM
<PAGE>

                                    DIAGRAM

<PAGE>

                                                                   EXHIBIT 10.58


                                SEQUENOM, INC.
                           STOCK ISSUANCE AGREEMENT
                           ------------------------

          AGREEMENT made as of this ____ day of ___________ 199__, by and
between Sequenom, Inc., a Delaware corporation, and _____________________,
Participant in the Corporation's 1998 Stock Option/Stock Issuance Plan.

          All capitalized terms in this Agreement shall have the meaning
assigned to them in this Agreement or in the attached Appendix.

     A.   PURCHASE OF SHARES
          ------------------

          1.   Purchase.  Participant hereby purchases ___________________
               --------
shares of Common Stock (the "Purchased Shares") pursuant to the provisions of
the Stock Issuance Program at the purchase price of $_______________ per share
(the "Purchase Price").

          2.   Payment.  Concurrently with the delivery of this Agreement to the
               -------
Corporation, Participant shall pay the Purchase Price for the Purchased Shares
in cash or cash equivalent and shall deliver a duly-executed blank Assignment
Separate from Certificate (in the form attached hereto as Exhibit I) with
respect to the Purchased Shares.

          3.   Stockholder Rights.  Until such time as the Corporation exercises
               ------------------
the Repurchase Right or the First Refusal Right, Participant (or any successor
in interest) shall have all stockholder rights (including voting, dividend and
liquidation rights) with respect to the Purchased Shares, subject, however, to
the transfer restrictions of Articles B and C.

     B.   SECURITIES LAW COMPLIANCE
          -------------------------

          1.   Restricted Securities.  The Purchased Shares have not been
               ---------------------
registered under the 1933 Act and are being issued to Participant in reliance
upon the exemption from such registration provided by SEC Rule 701 for stock
issuances under compensatory benefit plans such as the Plan. Participant hereby
confirms that Participant has been informed that the Purchased Shares are
restricted securities under the 1933 Act and may not be resold or transferred
unless the Purchased Shares are first registered under the Federal securities
laws or unless an exemption from such registration is available. Accordingly,
Participant hereby acknowledges that Participant is prepared to hold the
Purchased Shares for an indefinite period and that Participant is aware that SEC
Rule 144 issued under the 1933 Act which exempts certain resales of unrestricted
securities is not presently available to exempt the resale of the Purchased
Shares from the registration requirements of the 1933 Act.
<PAGE>

          2.   Disposition of Purchased Shares. Participant shall make no
               -------------------------------
disposition of the Purchased Shares (other than a Permitted Transfer) unless and
until there is compliance with all of the following requirements:

               (i)    Participant shall have provided the Corporation with a
     written summary of the terms and conditions of the proposed disposition.

               (ii)   Participant shall have complied with all requirements of
     this Agreement applicable to the disposition of the Purchased Shares.

               (iii)  Participant shall have provided the Corporation with
     written assurances, in form and substance satisfactory to the Corporation,
     that (a) the proposed disposition does not require registration of the
     Purchased Shares under the 1933 Act or (b) all appropriate action necessary
     for compliance with the registration requirements of the 1933 Act or any
     exemption from registration available under the 1933 Act (including Rule
     144) has been taken.

          The Corporation shall not be required (i) to transfer on its books any
                                ---
Purchased Shares which have been sold or transferred in violation of the
provisions of this Agreement or (ii) to treat as the owner of the Purchased
                             --
Shares, or otherwise to accord voting, dividend or liquidation rights to, any
transferee to whom the Purchased Shares have been transferred in contravention
of this Agreement.

          3.   Restrictive Legends.  The stock certificates for the Purchased
               -------------------
Shares shall be endorsed with one or more of the following restrictive legends:

          "The shares represented by this certificate have not been registered
     under the Securities Act of 1933. The shares may not be sold or offered for
     sale in the absence of (a) an effective registration statement for the
     shares under such Act, (b) a "no action" letter of the Securities and
     Exchange Commission with respect to such sale or offer or (c) satisfactory
     assurances to the Corporation that registration under such Act is not
     required with respect to such sale or offer."

          "The shares represented by this certificate are subject to certain
     repurchase rights and rights of first refusal granted to the Corporation
     and accordingly may not be sold, assigned, transferred, encumbered, or in
     any manner disposed of except in conformity with the terms of a written
     agreement dated __________, 199___, between the Corporation and the
     registered holder of the shares (or the predecessor in interest to the
     shares). A copy of such agreement is maintained at the Corporation's
     principal corporate offices."

                                       2.
<PAGE>

     C.   TRANSFER RESTRICTIONS
          ---------------------

          1.   Restriction on Transfer.  Except for any Permitted Transfer,
               -----------------------
Participant shall not transfer, assign, encumber or otherwise dispose of any of
the Purchased Shares which are subject to the Repurchase Right. In addition,
Purchased Shares which are released from the Repurchase Right shall not be
transferred, assigned, encumbered or otherwise disposed of in contravention of
the First Refusal Right or the Market Stand-Off.

          2.   Transferee Obligations.  Each person (other than the Corporation)
               ----------------------
to whom the Purchased Shares are transferred by means of a Permitted Transfer
must, as a condition precedent to the validity of such transfer, acknowledge in
writing to the Corporation that such person is bound by the provisions of this
Agreement and that the transferred shares are subject to (i) the Repurchase
Right, (ii) the First Refusal Right and (iii) the Market Stand-Off, to the same
extent such shares would be so subject if retained by Participant.

          3.   Market Stand-Off.
               ----------------

               (a)  In connection with any underwritten public offering by the
Corporation of its equity securities pursuant to an effective registration
statement filed under the 1933 Act, including the Corporation's initial public
offering, Owner shall not sell, make any short sale of, loan, hypothecate,
pledge, grant any option for the purchase of, or otherwise dispose or transfer
for value or otherwise agree to engage in any of the foregoing transactions with
respect to, any Purchased Shares without the prior written consent of the
Corporation or its underwriters. Such restriction (the "Market Stand-Off") shall
be in effect for such period of time from and after the effective date of the
final prospectus for the offering as may be requested by the Corporation or such
underwriters. In no event, however, shall such period exceed one hundred eighty
(180) days and the Market Stand-Off shall in all events terminate two (2) years
after the effective date of the Corporation's initial public offering.

               (b)  Owner shall be subject to the Market Stand-Off provided and
                                                                   ------------
only if the officers and directors of the Corporation are also subject to
- -------
similar restrictions.

               (c)  Any new, substituted or additional securities which are by
reason of any Recapitalization or Reorganization distributed with respect to the
Purchased Shares shall be immediately subject to the Market Stand-Off, to the
same extent the Purchased Shares are at such time covered by such provisions.

               (d)  In order to enforce the Market Stand-Off, the Corporation
may impose stop-transfer instructions with respect to the Purchased Shares until
the end of the applicable stand-off period.

                                       3.
<PAGE>

     D.   REPURCHASE RIGHT
          ----------------

          1.   Grant.  The Corporation is hereby granted the right (the
               -----
"Repurchase Right"), exercisable at any time during the sixty (60)-day period
following the date Participant ceases for any reason to remain in Service, to
repurchase at the Purchase Price any or all of the Purchased Shares in which
Participant is not, at the time of his or her cessation of Service, vested in
accordance with the provisions of the Vesting Schedule set forth in Paragraph
D.3 or the special vesting acceleration provisions of Paragraph D.5 (such shares
to be hereinafter referred to as the "Unvested Shares").

          2.   Exercise of the Repurchase Right.  The Repurchase Right shall be
               --------------------------------
exercisable by written notice delivered to each Owner of the Unvested Shares
prior to the expiration of the sixty (60)-day exercise period. The notice shall
indicate the number of Unvested Shares to be repurchased and the date on which
the repurchase is to be effected, such date to be not more than thirty (30) days
after the date of such notice. The certificates representing the Unvested Shares
to be repurchased shall be delivered to the Corporation on or before the close
of business on the date specified for the repurchase. Concurrently with the
receipt of such stock certificates, the Corporation shall pay to Owner, in cash
or cash equivalents (including the cancellation of any purchase-money
indebtedness), an amount equal to the Purchase Price previously paid for the
Unvested Shares which are to be repurchased from Owner.

          3.   Termination of the Repurchase Right.  The Repurchase Right shall
               -----------------------------------
terminate with respect to any Unvested Shares for which it is not timely
exercised under Paragraph D.2.  In addition, the Repurchase Right shall
terminate and cease to be exercisable with respect to any and all Purchased
Shares in which Participant vests in accordance with the following Vesting
Schedule:

          Participant shall vest in twenty-five percent (25%) of the Purchased
     Shares, and the Repurchase Right shall concurrently lapse with respect to
     those Purchased Shares, upon Participant's completion of one (1) year of
     Service measured from ___________________, 199_____.

          Participant shall vest in the remaining seventy-five percent (75%) of
     the Purchased Shares, and the Repurchase Right shall concurrently lapse
     with respect to those Purchased Shares, in a series of thirty-six (36)
     successive equal monthly installments upon Participant's completion of each
     additional month of Service over the thirty-six (36)-month period measured
     from the date on which the first twenty-five percent (25%) of the Purchased
     Shares vests hereunder.

          All Purchased Shares as to which the Repurchase Right lapses shall,
however, remain subject to (i) the First Refusal Right and (ii) the Market
Stand-Off.

                                       4.
<PAGE>

          4.   Recapitalization. Any new, substituted or additional securities
               ----------------
or other property (including cash paid other than as a regular cash dividend)
which is by reason of any Recapitalization distributed with respect to the
Purchased Shares shall be immediately subject to the Repurchase Right and any
escrow requirements hereunder, but only to the extent the Purchased Shares are
at the time covered by such right or escrow requirements. Appropriate
adjustments to reflect such distribution shall be made to the number and/or
class of Purchased Shares subject to this Agreement and to the price per share
to be paid upon the exercise of the Repurchase Right in order to reflect the
effect of any such Recapitalization upon the Corporation's capital structure;
provided, however, that the aggregate purchase price shall remain the same.
- --------

          5.   Corporate Transaction.
               ---------------------

               (a)  The Repurchase Right shall automatically terminate in its
entirety, and all the Purchased Shares shall vest in full, immediately prior to
the consummation of any Corporate Transaction, except to the extent the
Repurchase Right is to be assigned to the successor entity in such Corporate
Transaction.

               (b)  To the extent the Repurchase Right remains in effect
following a Corporate Transaction, such right shall apply to any new securities
or other property (including any cash payments) received in exchange for the
Purchased Shares in consummation of the Corporate Transaction, but only to the
extent the Purchased Shares are at the time covered by such right. Appropriate
adjustments shall be made to the price per share payable upon exercise of the
Repurchase Right to reflect the effect of the Corporate Transaction upon the
Corporation's capital structure; provided, however, that the aggregate purchase
                                 --------
price shall remain the same. The new securities or other property (including any
cash payments) issued or distributed with respect to the Purchased Shares in
consummation of the Corporate Transaction shall be immediately deposited in
escrow with the Corporation (or the successor entity) and shall not be released
from escrow until Participant vests in such securities or other property in
accordance with the same Vesting Schedule in effect for the Purchased Shares.

               (c)  The Repurchase Right may also terminate on an accelerated
basis, and the Purchased Shares shall immediately vest in full, in accordance
with the terms and conditions of any special addendum attached to this
Agreement.

     E.   RIGHT OF FIRST REFUSAL
          ----------------------

          1.   Grant.  The Corporation is hereby granted the right of first
               -----
refusal (the "First Refusal Right"), exercisable in connection with any proposed
transfer of the Purchased Shares in which Participant has vested in accordance
with the provisions of Article D. For purposes of this Article E, the term
"transfer" shall include any sale, assignment, pledge, encumbrance or other
disposition of the Purchased Shares intended to be made by Owner, but shall not
include any Permitted Transfer.

                                       5.
<PAGE>

          2.   Notice of Intended Disposition.  In the event any Owner of
               ------------------------------
Purchased Shares in which Participant has vested desires to accept a bona fide
third-party offer for the transfer of any or all of such shares (the Purchased
Shares subject to such offer to be hereinafter referred to as the "Target
Shares"), Owner shall promptly (i) deliver to the Corporation written notice
(the "Disposition Notice") of the terms of the offer, including the purchase
price and the identity of the third-party offeror, and (ii) provide satisfactory
proof that the disposition of the Target Shares to such third-party offeror
would not be in contravention of the provisions set forth in Articles B and C.

          3.   Exercise of the First Refusal Right.  The Corporation shall, for
               -----------------------------------
a period of twenty-five (25) days following receipt of the Disposition Notice,
have the right to repurchase any or all of the Target Shares subject to the
Disposition Notice upon the same terms as those specified therein or upon such
other terms (not materially different from those specified in the Disposition
Notice) to which Owner consents. Such right shall be exercisable by delivery of
written notice (the "Exercise Notice") to Owner prior to the expiration of the
twenty-five (25)-day exercise period. If such right is exercised with respect to
all the Target Shares, then the Corporation shall effect the repurchase of such
shares, including payment of the purchase price, not more than five (5) business
days after delivery of the Exercise Notice; and at such time the certificates
representing the Target Shares shall be delivered to the Corporation.

          Should the purchase price specified in the Disposition Notice be
payable in property other than cash or evidences of indebtedness, the
Corporation shall have the right to pay the purchase price in the form of cash
equal in amount to the value of such property. If Owner and the Corporation
cannot agree on such cash value within ten (10) days after the Corporation's
receipt of the Disposition Notice, the valuation shall be made by an appraiser
of recognized standing selected by Owner and the Corporation or, if they cannot
agree on an appraiser within twenty (20) days after the Corporation's receipt of
the Disposition Notice, each shall select an appraiser of recognized standing
and the two (2) appraisers shall designate a third appraiser of recognized
standing, whose appraisal shall be determinative of such value. The cost of such
appraisal shall be shared equally by Owner and the Corporation. The closing
shall then be held on the later of (i) the fifth (5th) business day following
                          -----
delivery of the Exercise Notice or (ii) the fifth (5th) business day after such
valuation shall have been made.

          4.   Non-Exercise of the First Refusal Right.  In the event the
               ---------------------------------------
Exercise Notice is not given to Owner prior to the expiration of the twenty-five
(25)-day exercise period, Owner shall have a period of thirty (30) days
thereafter in which to sell or otherwise dispose of the Target Shares to the
third-party offeror identified in the Disposition Notice upon terms (including
the purchase price) no more favorable to such third-party offeror than those
specified in the Disposition Notice; provided, however, that any such sale or
                                     --------
disposition must not be effected in contravention of the provisions of Articles
B and C.  The third-party offeror shall acquire the Target Shares free and clear
of the First Refusal Right, but the acquired shares shall remain subject to the
provisions of Article B and Paragraph C.3.  In the event Owner does not effect
such sale or disposition of the Target Shares within the specified thirty
(30)-day period, the First Refusal Right shall continue to be applicable to any
subsequent disposition of the Target Shares by Owner until such right lapses.

                                       6.
<PAGE>

          5.   Partial Exercise of the First Refusal Right.  In the event the
               -------------------------------------------
Corporation makes a timely exercise of the First Refusal Right with respect to a
portion, but not all, of the Target Shares specified in the Disposition Notice,
Owner shall have the option, exercisable by written notice to the Corporation
delivered within five (5) business days after Owner's receipt of the Exercise
Notice, to effect the sale of the Target Shares pursuant to either of the
following alternatives:

                         (i)  sale or other disposition of all the Target Shares
     to the third-party offeror identified in the Disposition Notice, but in
     full compliance with the requirements of Paragraph E.4, as if the
     Corporation did not exercise the First Refusal Right; or

                         (ii) sale to the Corporation of the portion of the
     Target Shares which the Corporation has elected to purchase, such sale to
     be effected in substantial conformity with the provisions of Paragraph E.3.
     The First Refusal Right shall continue to be applicable to any subsequent
     disposition of the remaining Target Shares until such right lapses.

          Owner's failure to deliver timely notification to the Corporation
shall be deemed to be an election by Owner to sell the Target Shares pursuant to
alternative (i) above.

          6.   Recapitalization/Reorganization.
               -------------------------------

               (a)  Any new, substituted or additional securities or other
property which is by reason of any Recapitalization distributed with respect to
the Purchased Shares shall be immediately subject to the First Refusal Right,
but only to the extent the Purchased Shares are at the time covered by such
right.

               (b)  In the event of a Reorganization, the First Refusal Right
shall remain in full force and effect and shall apply to the new capital stock
or other property received in exchange for the Purchased Shares in consummation
of the Reorganization, but only to the extent the Purchased Shares are at the
time covered by such right.

          7.   Lapse.  The First Refusal Right shall lapse upon the earliest to
               -----                                                --------
occur of (i) the first date on which shares of the Common Stock are held of
record by more than five hundred (500) persons, (ii) a determination made by the
Board that a public market exists for the outstanding shares of Common Stock or
(iii) a firm commitment underwritten public offering, pursuant to an effective
registration statement under the 1933 Act, covering the offer and sale of the
Common Stock in the aggregate amount of at least ten million dollars
($10,000,000). However, the Market Stand-Off shall continue to remain in full
force and effect following the lapse of the First Refusal Right.

                                       7.
<PAGE>

     F.   SPECIAL TAX ELECTION
          --------------------

          1.   Section 83(b) Election.  Under Code Section 83, the excess of
               -----------------------
the Fair Market Value of the Purchased Shares on the date any forfeiture
restrictions applicable to such shares lapse over the Purchase Price paid for
such shares will be reportable as ordinary income on the lapse date.  For this
purpose, the term "forfeiture restrictions" includes the right of the
Corporation to repurchase the Purchased Shares pursuant to the Repurchase Right.
Participant may elect under Code Section 83(b) to be taxed at the time the
Purchased Shares are acquired, rather than when and as such Purchased Shares
cease to be subject to such forfeiture restrictions.  Such election must be
filed with the Internal Revenue Service within thirty (30) days after the date
of this Agreement.  Even if the Fair Market Value of the Purchased Shares on the
date of this Agreement equals the Purchase Price paid (and thus no tax is
payable), the election must be made to avoid adverse tax consequences in the
future.  THE FORM FOR MAKING THIS ELECTION IS ATTACHED AS EXHIBIT II HERETO.
PARTICIPANT UNDERSTANDS THAT FAILURE TO MAKE THIS FILING WITHIN THE APPLICABLE
THIRTY (30)-DAY PERIOD WILL RESULT IN THE RECOGNITION OF ORDINARY INCOME AS THE
FORFEITURE RESTRICTIONS LAPSE.

          2.   FILING RESPONSIBILITY.  PARTICIPANT ACKNOWLEDGES THAT IT IS
               ---------------------
PARTICIPANT'S SOLE RESPONSIBILITY, AND NOT THE CORPORATION'S, TO FILE A TIMELY
ELECTION UNDER CODE SECTION 83(b), EVEN IF PARTICIPANT REQUESTS THE CORPORATION
OR ITS REPRESENTATIVES TO MAKE THIS FILING ON HIS OR HER BEHALF.

     G.   GENERAL PROVISIONS
          ------------------

          1.   Assignment.  The Corporation may assign the Repurchase Right
               ----------
and/or the First Refusal Right to any person or entity selected by the Board,
including (without limitation) one or more stockholders of the Corporation.

          2.   No Employment or Service Contract.  Nothing in this Agreement or
               ---------------------------------
in the Plan shall confer upon Participant any right to continue in Service for
any period of specific duration or interfere with or otherwise restrict in any
way the rights of the Corporation (or any Parent or Subsidiary employing or
retaining Participant) or of Participant, which rights are hereby expressly
reserved by each, to terminate Participant's Service at any time for any reason,
with or without cause.

          3.   Notices.  Any notice required to be given under this Agreement
               -------
shall be in writing and shall be deemed effective upon personal delivery or upon
deposit in the U.S. mail, registered or certified, postage prepaid and properly
addressed to the party entitled to such notice at the address indicated below
such party's signature line on this Agreement or at such other address as such
party may designate by ten (10) days advance written notice under this paragraph
to all other parties to this Agreement.

                                       8.
<PAGE>

          4.   No Waiver.  The failure of the Corporation in any instance to
               ---------
exercise the Repurchase Right or the First Refusal Right shall not constitute a
waiver of any other repurchase rights and/or rights of first refusal that may
subsequently arise under the provisions of this Agreement or any other agreement
between the Corporation and Participant.  No waiver of any breach or condition
of this Agreement shall be deemed to be a waiver of any other or subsequent
breach or condition, whether of like or different nature.

          5.   Cancellation of Shares.  If the Corporation shall make available,
               ----------------------
at the time and place and in the amount and form provided in this Agreement, the
consideration for the Purchased Shares to be repurchased in accordance with the
provisions of this Agreement, then from and after such time, the person from
whom such shares are to be repurchased shall no longer have any rights as a
holder of such shares (other than the right to receive payment of such
consideration in accordance with this Agreement).  Such shares shall be deemed
purchased in accordance with the applicable provisions hereof, and the
Corporation shall be deemed the owner and holder of such shares, whether or not
the certificates therefor have been delivered as required by this Agreement.

     H.   MISCELLANEOUS PROVISIONS
          ------------------------

          1.   Governing Law.  This Agreement shall be governed by, and
               -------------
construed in accordance with, the laws of the State of California without resort
to that State's conflict-of-laws rules.

          2.   Participant Undertaking.  Participant hereby agrees to take
               -----------------------
whatever additional action and execute whatever additional documents the
Corporation may deem necessary or advisable in order to carry out or effect one
or more of the obligations or restrictions imposed on either Participant or the
Purchased Shares pursuant to the provisions of this Agreement.

          3.   Agreement is Entire Contract.  This Agreement constitutes the
               ----------------------------
entire contract between the parties hereto with regard to the subject matter
hereof.  This Agreement is made pursuant to the provisions of the Plan and shall
in all respects be construed in conformity with the  terms of the Plan.

          4.   Counterparts.  This Agreement may be executed in counterparts,
               ------------
each of which shall be deemed to be an original, but all of which together shall
constitute one and the same instrument.

                                       9.
<PAGE>

          5.   Successors and Assigns. The provisions of this Agreement shall
               ----------------------
inure to the benefit of, and be binding upon, the Corporation and its successors
and assigns and upon Participant, Participant's assigns and the legal
representatives, heirs and legatees of Participant's estate, whether or not any
such person shall have become a party to this Agreement and have agreed in
writing to join herein and be bound by the terms hereof.

          IN WITNESS WHEREOF, the parties have executed this Agreement on the
day and year first indicated above.


                                        SEQUENOM, INC.


                                        By:  ________________________

                                        Title: ______________________

                                        Address: ____________________

                                                 ____________________


                                                 ____________________
                                                     PARTICIPANT

                                        Address: ____________________

                                                 ____________________

                                      10.
<PAGE>

                            SPOUSAL ACKNOWLEDGMENT

          The undersigned spouse of Participant has read and hereby approves the
foregoing Stock Issuance Agreement. In consideration of the Corporation's
granting Participant the right to acquire the Purchased Shares in accordance
with the terms of such Agreement, the undersigned hereby agrees to be
irrevocably bound by all the terms of such Agreement, including (without
limitation) the right of the Corporation (or its assigns) to purchase any
Purchased Shares in which Participant is not vested at the time of his or her
cessation of Service.

                                            ___________________________
                                             PARTICIPANT'S SPOUSE

                                   Address:  __________________________

                                             __________________________
<PAGE>

                                   EXHIBIT I


                     ASSIGNMENT SEPARATE FROM CERTIFICATE

          FOR VALUE RECEIVED ____________ hereby sell(s), assign(s) and
transfer(s) unto Sequenom, Inc. (the "Corporation"), ______________ (_____)
shares of the Common Stock of the Corporation standing in his or her name on the
books of the Corporation represented by Certificate No. _______________ herewith
and do(es) hereby irrevocably constitute and appoint _________________ Attorney
to transfer the said stock on the books of the Corporation with full power of
substitution in the premises.

Dated:  ___________


                                    Signature ___________________________


Instruction: Please do not fill in any blanks other than the signature line.
Please sign exactly as you would like your name to appear on the issued stock
certificate. The purpose of this assignment is to enable the Corporation to
exercise the Repurchase Right without requiring additional signatures on the
part of Participant.
<PAGE>

                                  EXHIBIT II

                          SECTION 83(b) TAX ELECTION
<PAGE>

                          SECTION 83(b) TAX ELECTION

This statement is being made under Section 83(b) of the Internal Revenue Code,
pursuant to Treas. Reg. Section 1.83-2.

(1)  The taxpayer who performed the services is:

     Name:
     Address:
     Taxpayer Ident. No.:

(2)  The property with respect to which the election is being made is
     ______________ shares of the common stock of Sequenom, Inc..

(3)  The property was issued on __________________, 199___.

(4)  The taxable year in which the election is being made is the calendar year
     1998.

(5)  The property is subject to a repurchase right pursuant to which the issuer
     has the right to acquire the property at the original purchase price if for
     any reason taxpayer's service with the issuer terminates. The issuer's
     repurchase right lapses in a series of annual and monthly installments over
     a four (4)-year period ending on ________________, 200___.

(6)  The fair market value at the time of transfer (determined without regard to
     any restriction other than a restriction which by its terms will never
     lapse) is $_____ per share.

(7)  The amount paid for such property is $ _______ per share.

(8)  A copy of this statement was furnished to Sequenom, Inc. for whom taxpayer
     rendered the services underlying the transfer of property.

(9)  This statement is executed on _______________, 199___.


___________________________________   _________________________________
Spouse (if any)                       Taxpayer


This election must be filed with the Internal Revenue Service Center with which
taxpayer files his or her Federal income tax returns and must be made within
thirty (30) days after the execution date of the Stock Issuance Agreement. This
filing should be made by registered or certified mail, return receipt requested.
Participant must retain two (2) copies of the completed form for filing with his
or her Federal and state tax returns for the current tax year and an additional
copy for his or her records.
<PAGE>

                                  EXHIBIT III

                     1998 STOCK OPTION/STOCK ISSUANCE PLAN
<PAGE>

                                   APPENDIX
                                   --------

          The following definitions shall be in effect under the Agreement:

     A.   Agreement shall mean this Stock Issuance Agreement.
          ---------

     B.   Board shall mean the Corporation's Board of Directors.
          -----

     C.   Code shall mean the Internal Revenue Code of 1986, as amended.
          ----

     D.   Common Stock shall mean the Corporation's common stock.
          ------------

     E.   Corporate Transaction shall mean either of the following stockholder-
          ---------------------
approved transactions:

               (i)  a merger or consolidation in which securities possessing
more than fifty percent (50%) of the total combined voting power of the
Corporation's outstanding securities are transferred to a person or persons
different from the persons holding those securities immediately prior to such
transaction, or

               (ii) the sale, transfer or other disposition of all or
substantially all of the Corporation's assets in complete liquidation or
dissolution of the Corporation.

     F.   Corporation shall mean Sequenom, Inc., a Delaware corporation, and any
          -----------
successor corporation to all or substantially all of the assets or voting stock
of Sequenom, Inc. which shall by appropriate action adopt the Plan.

     G.   Disposition Notice shall have the meaning assigned to such term in
          ------------------
Paragraph E.2.

     H.   Exercise Notice shall have the meaning assigned to such term in
          ---------------
Paragraph E.3.

     I.   Fair Market Value of a share of Common Stock on any relevant date,
          -----------------
prior to the initial public offering of the Common Stock, shall be determined by
the Plan Administrator after taking into account such factors as it shall deem
appropriate.

     J.   First Refusal Right shall mean the right granted to the Corporation in
          -------------------
accordance with Article E.

     K.   Market Stand-Off shall mean the market stand-off restriction specified
          ----------------
in Paragraph C.3.

                                     A-1.
<PAGE>

     L.   1933 Act shall mean the Securities Act of 1933, as amended.
          --------

     M.   Owner shall mean Participant and all subsequent holders of the
          -----
Purchased Shares who derive their chain of ownership through a Permitted
Transfer from Participant.

     N.   Parent shall mean any corporation (other than the Corporation) in an
          ------
unbroken chain of corporations ending with the Corporation, provided each
corporation in the unbroken chain (other than the Corporation) owns, at the time
of the determination, stock possessing fifty percent (50%) or more of the total
combined voting power of all classes of stock in one of the other corporations
in such chain.

     O.   Participant shall mean the person to whom shares are issued under the
          -----------
Stock Issuance Program.

     P.   Permitted Transfer shall mean (i) a gratuitous transfer of the
          ------------------
Purchased Shares, provided and only if Participant obtains the Corporation's
                  --------------------
prior written consent to such transfer, (ii) a transfer of title to the
Purchased Shares effected pursuant to Participant's will or the laws of
intestate succession following Participant's death or (iii) a transfer to the
Corporation in pledge as security for any purchase-money indebtedness incurred
by Participant in connection with the acquisition of the Purchased Shares.

     Q.   Plan shall mean the Corporation's 1998 Stock Option/Stock Issuance
          ----
Plan attached hereto as Exhibit III.

     R.   Plan Administrator shall mean either the Board or a committee of the
          ------------------
Board acting in its capacity as administrator of the Plan.

     S.   Purchase Price shall have the meaning assigned to such term in
          --------------
Paragraph A.1.

     T.   Purchased Shares shall have the meaning assigned to such term in
          ----------------
Paragraph A.1.

     U.   Recapitalization shall mean any stock split, stock dividend,
          ----------------
recapitalization, combination of shares, exchange of shares or other change
affecting the Corporation's outstanding Common Stock as a class without the
Corporation's receipt of consideration.

     V.   Reorganization shall mean any of the following transactions:
          --------------

               (i)    a merger or consolidation in which the Corporation is not
     the surviving entity,

               (ii)   a sale, transfer or other disposition of all or
     substantially all of the Corporation's assets,

                                     A-2.
<PAGE>

               (iii)  a reverse merger in which the Corporation is the surviving
     entity but in which the Corporation's outstanding voting securities are
     transferred in whole or in part to a person or persons different from the
     persons holding those securities immediately prior to the merger, or

               (iv)   any transaction effected primarily to change the state in
     which the Corporation is incorporated or to create a holding company
     structure.

     W.   Repurchase Right shall mean the right granted to the Corporation in
          ----------------
accordance with Article D.

     X.   SEC shall mean the Securities and Exchange Commission.
          ---

     Y.   Service shall mean the Participant's performance of services for the
          -------
Corporation (or any Parent or Subsidiary) in the capacity of an employee,
subject to the control and direction of the employer entity as to both the work
to be performed and the manner and method of performance, a non-employee member
of the board of directors or an independent consultant.

     Z.   Stock Issuance Program shall mean the Stock Issuance Program under the
          ----------------------
Plan.

     AA.  Subsidiary shall mean any corporation (other than the Corporation) in
          ----------
an unbroken chain of corporations beginning with the Corporation, provided each
corporation (other than the last corporation) in the unbroken chain owns, at the
time of the determination, stock possessing fifty percent (50%) or more of the
total combined voting power of all classes of stock in one of the other
corporations in such chain.

     AB.  Target Shares shall have the meaning assigned to such term in
          -------------
Paragraph E.2.

     AC.  Vesting Schedule shall mean the vesting schedule specified in
          ----------------
Paragraph D.3 pursuant to which Participant is to vest in the Purchased Shares
in a series of installments over the Participant's period of Service.

     AD.  Unvested Shares shall have the meaning assigned to such term in
          ---------------
Paragraph D.1.

                                     A-3.


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