CELLOMICS INC
S-1/A, EX-10.21, 2000-11-16
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                                                   Exhibit 10.21


                               FIRST AMENDMENT TO
                         COMMON STOCK PURCHASE AGREEMENT


         This FIRST AMENDMENT to COMMON STOCK PURCHASE AGREEMENT (this
"Amendment") is made and entered into this ___ day of October 2000, by and
between BECKMAN COULTER, INC. ("Beckman") and CELLOMICS, INC. (the "Company").


                                   WITNESSETH


         WHEREAS, Beckman and the Company have entered into a certain Common
Stock Purchase Agreement dated June 9, 2000 (the "Purchase Agreement") whereby
Beckman purchased 153,256 shares of the Company's Common Stock; and

         WHEREAS, Beckman and the Company wish to amend certain provisions of
the Purchase Agreement.

         NOW, THEREFORE, intending to be legally bound hereby, the parties
hereto amend the Purchase Agreement and agree as follows:

         1. COMMON STOCK. Beckman and the Company agree that the definition of
         Common Stock, as such term is used in the Purchase Agreement, shall be
         deleted in its entirety and replaced with the following:

                  Common Stock shall mean the Company's authorized Eight Million
                  (8,000,000) shares of Common Stock, par value $.01 per share.

         2. PREFERRED STOCK. Beckman and the Company agree that the definition
         of Preferred Stock, as such term is used in the Purchase Agreement,
         shall be deleted in its entirety and replaced with the following:

                  Preferred Stock shall mean the Company's authorized Four
                  Million Three Hundred Seventy-Four Thousand Five Hundred
                  (4,374,500) shares of Preferred Stock, par value $.01 per
                  share.

         3. REPRESENTATIONS AND WARRANTIES. Except as is otherwise modified,
         amended and/or restated in this Section 3, the representations and
         warranties of the Company as are set forth in Section 5.1 of the
         Purchase Agreement shall be true and correct in all material respects
         as of the date of this Amendment.

                  a. ORGANIZATION AND STANDING; ARTICLES AND BYLAWS. Section 3.1
         of the Purchase Agreement is hereby amended in order to attach, as
         Exhibit A, the Company's Amended and Restated Certificate of
         Incorporation (the "Restated Certificate") as presently in effect on
         the date hereof.

                  b. CAPITALIZATION. Section 3.3 of the Purchase Agreement is
         hereby deleted in its entirety and replaced with the following:


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                  As of the date of this Amendment, the Company's authorized
                  capital stock consists of (a) Eight Million (8,000,000) shares
                  of Common Stock, par value $.01 per share of the Company (the
                  "Common Stock"), of which One Million Three Hundred
                  Thirty-Eight Thousand Five Hundred Seventy-Five (1,338,575)
                  shares are issued and outstanding, and (b) Four Million Three
                  Hundred Seventy-Four Thousand Five Hundred (4,374,500) shares
                  of Preferred Stock, par value $.01 per share of the Company
                  ("Preferred Stock"), of which (i) Two Million Twenty-Four
                  Thousand Five Hundred (2,024,500) shares have been designated
                  Series A Preferred Stock, par value $.01 per share of the
                  Company (the "Series A Preferred"), of which One Million Nine
                  Hundred Sixty-Six Thousand Six Hundred Eighteen (1,966,618)
                  shares are issued and outstanding, (ii) Seven Hundred Thousand
                  (700,000) shares have been designated Series B Preferred
                  Stock, par value $.01 per share of the Company (the "Series B
                  Preferred"), of which Six Hundred Ninety-Three Thousand Six
                  Hundred Seventy-Five (693,675) shares are issued and
                  outstanding, and (iii) One Million Six Hundred Fifty Thousand
                  (1,650,000) shares have been designated as Series C Preferred
                  Stock, par value $.01 per share of the Company (the "Series C
                  Preferred"), of which One Million Six Hundred Forty-Five
                  Thousand Six Hundred Thirty-Nine(1,645,639) are issued and
                  outstanding. The Company has (i) issued warrants exercisable
                  for 388,141 and 57,829 shares of Common Stock and Preferred
                  Stock, respectively and (ii) reserved 742,900 shares of Common
                  Stock for issuance under its stock incentive plans, duly
                  adopted by the Board of Directors and approved by the
                  Company's stockholders of which options to purchase 493,057
                  shares of Common Stock have been granted. Upon consummation of
                  the Closing, all issued and outstanding shares of capital
                  stock of the Company will have been duly authorized and
                  validly issued, will be fully paid and nonassessable and will
                  have been issued in compliance with all applicable federal and
                  state securities laws. The Company holds no shares of its
                  capital stock in its treasury.

                  In the event of a sale of New Securities (as such term is
                  defined in that certain Amended and Restated Shareholders'
                  Agreement dated September 27, 2000 (the "Restated
                  Shareholders' Agreement")), each holder of Series A Preferred,
                  Series B Preferred and Series C Preferred (collectively, the
                  "Preferred Shareholders") have certain preemptive and
                  participation rights which entitle it to purchase and sell up
                  to its Preemptive Share (as such term is defined in the
                  Restated Shareholders' Agreement) of such New Securities.

                  Each Preferred Shareholder has certain conversion rights
                  pursuant to Article III, Part B, Section 3 of the Restated
                  Certificate which entitle it to convert each share of
                  Preferred Stock into such number of shares of Common Stock as
                  is determined by dividing $5.62 (with respect to a holder of
                  Series A Preferred), $12.07 (with respect to a holder of
                  Series B Preferred) or $18.23 (with respect to a holder of
                  Series C Preferred) by the Conversion Price (as such term is
                  defined in the Restated Certificate). The initial Conversion
                  Price is $5.62(with respect to a holder of Series A
                  Preferred), $12.07 (with respect to a holder of Series B
                  Preferred) or $18.23 (with respect to a holder of Series C
                  Preferred). However, if the Company should issue Additional
                  Shares of Common Stock (as such term is defined in the
                  Restated Certificate), the Conversion Price may, under certain
                  circumstance presented by the Restated Certificate be adjusted
                  to account for such additional issues.

                  Each Preferred Shareholder is entitled to certain dividend
                  rights under Article III, Part B, Section 6 of the Restated
                  Certificate which entitle it to receive cumulative, annual


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                  dividends at a rate equal to forty-five cents ($0.45) (with
                  respect to a holder of Series A Preferred), ninety-seven cents
                  ($0.97) (with respect to a holder of Series B Preferred) or
                  one dollar and forty six cents ($1.46) (with respect to a
                  holder of Series C Preferred) per annum per share. Dividends
                  payable on Preferred Stock may, at the Company's option, be
                  paid either in cash or in shares of Common Stock.

                  Pursuant to that certain Letter Agreement dated January 15,
                  1998 by and between the Company and Carl Zeiss Holding Co.
                  ("Zeiss"), Zeiss and Company have agreed that Zeiss shall have
                  the right to certain anti-dilution rights to which the holders
                  of the Series A Preferred are entitled under the conversion
                  rights provisions of the Restated Certificate.

                  On July 21, 1999, the Company entered into an agreement which
                  provided for an equipment financing line of credit with Oxford
                  Venture Finance, LLC ("OVF"). Under the agreement, OVF is
                  entitled to receive warrants to purchase shares of the
                  Company's common stock (with an exercise price of $6.60) equal
                  to 2.35% of the borrowings under the line of credit divided by
                  the $6.60 exercise price.

                  Except as set forth in this Section 3.3, there are no
                  outstanding options, warrants, rights (including conversion or
                  preemptive rights and rights of first refusal or similar
                  rights) for the purchase or acquisition from the Company of
                  any of its shares of capital stock.

                  c. AUTHORIZATION. The third sentence of Section 3.4 of the
         Purchase Agreement is hereby deleted in its entirety and replaced with
         the following:

                  The execution and delivery by the Company of this Agreement
                  and compliance herewith, and the offer, and subject to
                  obtaining requisite approvals of the Company's stockholders,
                  the issuance and sale of the Shares will not, with or without
                  notice or the passage of time or both, result in any violation
                  of and will not conflict with, or result in a breach of any of
                  the terms of, or constitute be affected, or result in the
                  creation of any mortgage, pledge, lien, encumbrance or charge
                  upon a default under any provision of, (i) any state or
                  federal law to which the Company is subject, (ii) the Amended
                  and Restated Certificate or By-Laws, or (iii) any material
                  mortgage, indenture, agreement, instrument, judgment, decree,
                  order, rule or regulation or other restriction to which the
                  Company is a party or by which it or any of its property is
                  bound, or may any of the properties or assets of the Company
                  pursuant to any such term or give any other person or entity
                  the right to accelerate the time for performance of any
                  obligation of the Company; provided, however, that,
                  notwithstanding the foregoing, the Purchaser, the holders of
                  Preferred Stock and Carl Zeiss Holding Co. have registration
                  rights that are similar in certain respects and may be
                  construed as competing rights.

                  d. NO MATERIAL ADVERSE CHANGE. The following provision shall
         be added as Section 3.12 of the Purchase Agreement:

                  Since June 9, 2000, the Company has not experienced any
                  occurrence or event which, to the knowledge of the Company, is
                  likely to result in a material adverse effect on the Company.


         4. RATIFICATION AND CAPITALIZED TERMS. Except as herein revised,
         Beckman and the Company hereby ratify and reaffirm the Purchase
         Agreement


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         in its entirety, and the Purchase Agreement remains in full force and
         effect. Capitalized terms used but not defined herein shall have the
         meanings ascribed to such terms in the Purchase Agreement.


         IN WITNESS WHEREOF, the parties hereto have caused this First Amendment
to Common Stock Purchase Agreement to be executed as of the day and year first
above written.

Attest:                             Beckman Coulter, Inc.




                                    By:         [Illegible]
----------------------------           --------------------------------
                                    Name:
                                    Title:



Attest:                             Cellomics, Inc.



                                    By: /s/ D. LANSING TAYLOR
-----------------------------          --------------------------------
                                         D. Lansing Taylor
                                         President


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