CENTREX INC
10SB12G, EX-8.1, 2000-11-27
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                          AGREEMENT AND PLAN OF MERGER

     This  Agreement  and Plan of Merger  ("Agreement")  is entered  into by and
among CENTREX,  INC., an Oklahoma  corporation  ("CENTREX"),  E.COLI MEASUREMENT
SYSTEMS,  INC., a Florida corporation  ("EMS"), and UTEK, LLC, a Florida limited
liability company ("UTEK").

     WHEREAS, UTEK is the majority shareholder of EMS; and

     WHEREAS,  Dr. Alonso Castro has invented a new  proprietary  technology and
related processes for the instantaneous and continuous detection and measurement
of the e.coli  bacteria  in water  systems and in process  fluids  ("Invention")
covered by the patents  ("Patents")  and patent  applications  pending  ("Patent
Applications") listed in Schedule 1; and

     WHEREAS,  EMS has entered into that certain License  Agreement  ("License")
with the Regents of the  University of California  ("UC") as operator of the Los
Alamos National Laboratories ("LANL"),  which grants EMS the exclusive worldwide
right to commercialize the Invention; and

     WHEREAS,  EMS has also  entered  into that  certain  Funds-In  Agreement No
98-053  ("Research  Agreement")  with UC and the Los Alamos National  Laboratory
("LANL"),  which provides for the funding of certain sponsored  research and the
completion of a prototype continuous e.coli detection and measurement system and
related research; and

     WHEREAS,  the parties desire to provide for the terms and  conditions  upon
which EMS will merge into CENTREX in a statutory merger ("Merger") in accordance
with 18  Oklahoma  Statutes,  Section  1082  of the  Oklahoma  General  Business
Corporation Act ("Oklahoma  Act") and Section 607.1107 of the Corporation Law of
Florida  ("Florida Act"),  upon consummation of which the assets and business of
EMS will be owned by CENTREX, all liabilities and obligations of EMS will become
the  liabilities  and  obligations  of CENTREX,  and all issued and  outstanding
shares of capital  stock of EMS will be  exchanged  for common stock of CENTREX;
and

     WHEREAS,  for federal  income tax purposes,  it is intended that the Merger
qualify as a tax-free  reorganization within the meaning of Section 368(a)(l)(A)
of the Internal Revenue Code of 1986, as amended ("Code").

     NOW,  THEREFORE,  in  consideration  of the premises and for other good and
valuable  consideration,  the  receipt,  adequacy and  sufficiency  of which are
hereby acknowledged, the parties agree as follows:


                                                  Sequentially numbered page 144
<PAGE>


                                    ARTICLE I
                                   THE MERGER

     1.01. The Merger

     (a)  Agreement  to  Merge.  Subject  to the terms  and  conditions  of this
Agreement, at the Effective Time, as defined below, EMS shall be merged with and
into  CENTREX  in  accordance  with the  provisions  of this  Agreement  and the
Oklahoma Act; the separate  corporate  existence of EMS shall cease; and CENTREX
shall  continue as the  surviving  corporation  ("Surviving  Corporation").  The
constituent corporations ("Constituent  Corporations") to the Merger are CENTREX
and EMS. The name of the  Surviving  Corporation,  CENTREX,  INC.,  shall not be
changed by reason of the Merger.

     (b) Effective Time. The Merger shall become  effective  ("Effective  Time")
upon filing of a  Certificate  of Merger  substantially  in the form attached as
Exhibit A ("Certificate  of Merger") with the Secretary of State of the State of
Oklahoma in accordance with applicable provisions of the Oklahoma Act.

     (c) Appointment of Service Agent.  CENTREX hereby irrevocably  appoints the
Secretary  of State of the State of  Florida  as its agent to accept  process in
Florida  in  any  proceeding  for  the  enforcement  of  any  obligation  of any
Constituent  Corporation  in  Florida  as  well as for  the  enforcement  of any
obligation of the Surviving Corporation arising from or by reason of the Merger,
including  any suit or other  proceeding  to  enforce  appraisal  rights  of any
shareholder of EMS.  CENTREX  designates  that all such process  received by the
Secretary of State of Florida shall be sent to CENTREX at 8908 South Yale, Suite
409, Tulsa, Oklahoma 74137-3545.

     (d) Effect of the  Merger.  At the  Effective  Time,  all  rights,  powers,
privileges,  franchises,  licenses and permits of the Constituent  Corporations,
and all  property,  real,  personal and mixed,  shall be vested in the Surviving
Corporation;  and all  debts,  duties,  liabilities  and  claims of every  kind,
character  and  description  of the  Constituent  Corporations  shall be  debts,
duties,  liabilities of and claims against of the Surviving  Corporation and may
be enforced  against  the  Surviving  Corporation  to the same extent as if such
debts,  duties,  liabilities  of and  claims  against  had been  incurred  by it
originally.  All rights of creditors  of the  Constituent  Corporations  and all
liens upon property of any Constituent Corporation shall be preserved unimpaired
and shall not be altered in any way by reason of the Merger.

     1.02.  Conversion of Stock.  At the Effective Time, by virtue of the Merger
and  without  any  action  on the part of the  shareholders  of the  Constituent
Corporations:

     (i) Each of the 1,000 shares of EMS that are issued and  outstanding at the
Effective  Time  shall be  converted  into 540  shares  of  common  stock of the
Surviving


                                       -2-

                                                  Sequentially numbered page 145
<PAGE>


Corporation.  The parties  agree that the agreed  fair  market  value of CENTREX
common stock is $.001 per share; and

     (ii) All  issued  and  outstanding  options,  warrants  or other  rights to
acquire any capital  stock of EMS at the  Effective  Time shall be reason of the
Merger  and  without  action on the part of the  holders  of any such  rights be
automatically canceled for all purposes; and

     (iii) Each share of common stock of CENTREX  issued and  outstanding at the
Effective Time shall remain issued and  outstanding as one share of common stock
of the Surviving Corporation.


     1.03. Effect of Merger.

     (a) Rights in EMS Cease.  At and after the  Effective  Time,  the holder of
each  certificate  of common  stock of EMS shall  cease to have any  rights as a
shareholder  of EMS. All  dividends or other  distributions  with respect to EMS
common stock prior to the Effective Time shall be payable to the shareholders of
EMS without  interest upon  surrender of  certificates  representing  EMS common
stock.

     (b) Closure of EMS Stock  Records.  From and after the Effective  Time, the
stock  transfer  books of EMS shall be  closed,  and there  shall be no  further
registration of stock transfers on the records of EMS.

     1.04.  Certificate  of  Incorporation  of the  Surviving  Corporation.  The
Certificate of the Surviving  Corporation  shall not be changed by reason of the
Merger.

     1.05.  Bylaws of the  Surviving  Corporation.  The Bylaws of the  Surviving
Corporation shall not be changed by reason of the Merger.

     1.06. Directors of the Surviving Coporation. The directors of the Surviving
Corporation  immediately  after the Effective Time shall be the persons named in
Exhibit  B until  each of  their  respective  successors  is  duly  elected  and
qualified.

     1.07. Officers of the Surviving Corporation.  The officers of the Surviving
Corporation  immediately after the Effective Time shall be the persons set forth
in Exhibit B until  each of their  respective  successors  is duly  elected  and
qualified.

     1.08. Closing. The Closing of the Merger shall take place at the offices of
Frederick K. Slicker,  8908 S. Yale,  Suite 410, Tulsa,  Oklahoma  74137-3545 at
5:00 p.m. local time on a mutually agreed date on or before June 30, 1999, or on
an earlier date as the parties  mutually  agree  ("Closing  Date").  The parties
agree to use their  good  faith  efforts to Close the Merger on or as soon after
March 31, 1999 as is reasonably possible.



                                       -3-

                                                  Sequentially numbered page 146
<PAGE>


                                   ARTICLE II
                         REPRESENTATIONS AND WARRANTIES

     2.01. General  Representations  and Warranties of UTEK. UTEK represents and
warrants to CENTREX that the facts set forth below are true and correct:

     (a) Organization. EMS is a corporation duly organized, validly existing and
in good  standing  under the laws of the State of Florida,  is  qualified  to do
business  as a  foreign  corporation  in each  other  jurisdiction  in which the
conduct  of  its  business  or the  ownership  of its  properties  require  such
qualification,  and has all  requisite  power and  authority  to  conduct  EMS's
business and operate properties.

     (b) Authorization.  The execution of this Agreement and the consummation of
the  Merger  and the  other  transactions  contemplated  hereby  have  been duly
authorized by the Board of Directors and Shareholders of EMS; no other corporate
action on its part is necessary  in order to execute,  deliver,  consummate  and
perform its obligations hereunder; and EMS has all requisite corporate and other
authority to execute and deliver this Agreement and consummate the  transactions
contemplated hereby.

     (c) Capitalization.  The authorized capital of EMS consists of 1,000 shares
of common stock,  par value $.001 per share;  at the date hereof,  950 shares of
its common  stock were  issued and  outstanding  and owned by UTEK and 50 shares
were owned by Dr. Gross, and no shares were held in its treasury. All issued and
outstanding  shares of common stock of EMS have been duly and validly issued and
are fully paid and  non-assessable  shares and have not been issued in violation
of any  preemptive or other rights of any other person or any  applicable  laws.
There are no outstanding options, warrants,  commitments,  calls or other rights
or agreements requiring it to issue any shares of EMS common stock or securities
convertible  into  shares of the  common  stock of EMS to anyone  for any reason
whatsoever.

     (d) Binding Effect. The execution,  delivery,  performance and consummation
of the Merger and the  transactions  contemplated  hereby  will not  violate any
obligation to which EMS is a party and will not create a default hereunder;  and
this  Agreement  constitutes  a legal,  valid  and  binding  obligation  of EMS,
enforceable  in  accordance  with its  terms,  except as the  enforcement  maybe
limited  by  bankruptcy,  insolvency,  moratorium,  or  similar  laws  affecting
creditor's  rights  generally  and by the  availability  of  injunctive  relief,
specific performance or other equitable remedies.

     (e) Litigation Relating to this Agreement.  There are no suits,  actions or
proceedings  pending or to the knowledge of EMS or UTEK threatened which seek to
enjoin the Merger or the  transactions  contemplated by this Agreement or which,
if adversely  decided,  would have a materially  adverse effect on the business,
results of operations, assets,



                                       -4-

                                                  Sequentially numbered page 147
<PAGE>


prospects,  the Patents,  the Patent  Applications,  the  License,  the Research
Agreement or the results of the operations of EMS.

     (f) No Conflicting  Agreements.  Neither the execution and delivery of this
Agreement  nor the  fulfillment  of or  compliance  by EMS  with  the  terms  or
provisions hereof will result in a breach of the terms, conditions or provisions
of, or  constitute a default  under,  or result in a violation of, the corporate
charter or bylaws of EMS, the Patents, the Patent Applications, the License, the
Research Agreement, or any agreement,  contract,  instrument, order, judgment or
decree to which EMS is a party or by which EMS or any of its assets is bound, or
violate any  provision of any  applicable  law, rule or regulation or any order,
decree,  writ or injunction of any court or governmental entity which materially
affects its assets or business.

     (g) Consents. No consent from or approval of any court, governmental entity
or any other person is necessary in  connection  with  execution and delivery of
this  Agreement by EMS or  performance  of the  obligations  of EMS hereunder or
under any other agreement to which EMS is a party;  and the  consummation of the
transactions contemplated by this Agreement will not require the approval of any
entity  or  person  or  prevent  the  termination  of the  Patents,  the  Patent
Applications,  the License,  the Research Agreement or any other material right,
privilege, license or agreement relating to EMS or its assets or business.

     (h) Title to Assets.  EMS has or will by Closing  have good and  marketable
title to its  assets  (tangible  and  intangible),  free and clear of all liens,
claims, charges, mortgages, options, restrictions, security agreements and other
encumbrances of every kind or nature whatsoever.

     (i) The  Patents,  the Patent  Applications,  the License and the  Research
Agreement.

          (1)  To the knowledge of UTEK and EMS, the Patents  listed in Schedule
               1 are valid and are in full  force and  effect to the  extent the
               Patents  have been  granted;  the Patent  Applications  which are
               pending are being  prosecuted in good faith with  diligence;  and
               neither  UTEK nor EMS has any reason to believe that these Patent
               Applications will not be granted; and

          (2)  To the knowledge of UTEK and EMS, the Invention does not and will
               not infringe the  intellectual  or other rights of another.  This
               representation  and warranty is not a representation  or warranty
               that there are no infringing intellectual rights of any other but
               is a  representation  and warranty only that neither EMS nor UTEK
               has any knowledge thereof;  and CENTREX acknowledges that neither
               UTEK nor EMS has conducted an independent investigation to



                                       -5-

                                                  Sequentially numbered page 148
<PAGE>


               determine whether the Invention infringes the rights of any other
               party or that the Invention itself is marketable; and

          (3)  The  Invention  is  owned  by UC  and UC has  all  right,  power,
               authority,  ownership  and  entitlement  to file,  prosecute  and
               maintain  in effect  the  Patents  and Patent  Applications  with
               respect to the Invention listed in Schedule 1 hereto; and

          (4)  Dr.  Castro is the only  Inventor  of the  Invention;  and he has
               assigned all his rights in the Invention to UC; and

          (5)  The License  Agreement  is in full force and effect and is legal,
               valid, binding and enforceable in accordance with its terms; and

          (6)  The Research  Agreement is in full force and effect and is legal,
               valid, binding and enforceable in accordance with its terms.

     (j)  Liabilities  of EMS. EMS has no assets,  no  liabilities  of any kind,
character or  description  except those created by the License  Agreement or the
Research Agreement.  All attorneys' fees and expenses relating to the filing and
the prosecution of the Patents and the Patent  Applications  which were incurred
prior to Closing will be paid before Closing.

     (k) Condition of Tangible  Assets.  All of the tangible  assets of EMS have
been  operated  in  accordance  with  customary  Operating  practices  generally
acceptable  in its  industry to which and have been  maintained  and are in good
working  order and repair in the ordinary  course of  business,  subject only to
reasonable and ordinary wear and tear.

     (l)  Financial  Statements.  The  unaudited  financial  statements  of  EMS
attached as Schedule 2.01(1) as of the Closing will present fairly its financial
position  and the  results of its  operations  on the dates and for the  periods
shown therein; provided,  however, that interim financial statements are subject
to customary year-end adjustments and accruals that, in the aggregate,  will not
have a material adverse effect on the overall financial  condition or results of
its  operations.  EMS has not  engaged  in any  business  not  reflected  in its
financial statements.  There have been no material adverse changes in the nature
of its business, prospects, the value of assets or the financial condition since
the date of its financial  statements.  There are no outstanding  obligations or
liabilities  of EMS  except  as  specifically  set  forth  in the EMS  financial
statements,  including the obligation to maintain the Patents from and after the
date of the License Agreement, or in a schedule attached hereto and specifically
agreed to by CENTREX.  In the event the  Inventor  ceases to be employed by LANL
prior to the  Closing  and  become  employed  by another  qualified  institution
eligible to accept  sponsored  research funds, EMS shall use its best good faith
efforts to cause the new institution to agree to continue the Research Agreement
relating to the Invention in accordance with an agreement acceptable to CENTREX.



                                       -6-

                                                  Sequentially numbered page 149
<PAGE>


     (m) Taxes.  All returns,  reports,  statements  and other  similar  filings
required to be filed by EMS with respect to any federal, state, local or foreign
taxes,  assessments,   interests,   penalties,   deficiencies,  fees  and  other
governmental  charges or impositions have been timely filed with the appropriate
governmental  agencies  in all  jurisdictions  in  which  such tax  returns  are
required to be filed;  all such tax returns  properly reflect all liabilities of
EMS for taxes for the  periods,  property  or events  covered  thereby;  and all
taxes,  whether or not reflected on those tax returns,  and all taxes claimed to
be due from EMS by any taxing authority,  have been properly paid, except to the
extent contested in good faith by appropriate proceedings and reserves have been
established  in its  financial  statements  to the full extent if the contest is
adversely  decided  against it. EMS has not received any notice of assessment or
proposed assessment in connection with any tax returns,  EMS has not extended or
waived  the  application  of any  statute  of  limitations  of any  jurisdiction
regarding the  assessment  or  collection  of any taxes.  There are no tax liens
(other than any lien which arises by operation of law for current  taxes not yet
due and  payable)  on any of its  assets.  There is no basis for any  additional
assessment of taxes,  interest or penalties.  EMS has made all deposits required
by law to be made with respect to employees'  withholding  and other  employment
taxes,  including  without  limitation the portion of such deposits  relating to
taxes imposed upon EMS.

     (n)  Absence of Certain  Changes or Events.  EMS has not,  and  without the
written consent of CENTREX, it will not have:

          (i)  Sold,  encumbered,  assigned or  transferred  any of its material
               assets or its interest in the Patents,  the Patent  Applications,
               the Research Agreement,  the License or any other material asset;
               or

          (ii) Amended or terminated the License or the Research Agreement; or

          (iii) Suffered any material damage, destruction or loss; or

          (iv) Received notice or have knowledge of any material  adverse effect
               on the Patents, the Patent  Applications,  the Research Agreement
               or the License or any other  material  asset or liability of EMS;
               or

          (v)  Made any  commitments or agreements for capital  expenditures  or
               otherwise; or

          (vi) Entered into any transaction or made any commitment not disclosed
               to CENTREX; or

          (vii)Agreed to take any of the actions set forth in this paragraph.



                                       -7-

                                                  Sequentially numbered page 150
<PAGE>


     (o)  Material  Contracts.  A complete  and  accurate  copy of all  material
agreements, contracts and commitments of the following types, whether written or
oral to which it is a party or is bound,  has been  provided to CENTREX and such
agreements are in full force and effect without amendment. In addition:

          (i)  There are no  outstanding  unpaid  promissory  notes,  mortgages,
               indentures,   deeds  of  trust,  security  agreements  and  other
               agreements and instruments  relating to the borrowing of money by
               or any extension of credit to EMS; and

          (ii) There are no outstanding operating  agreements,  lease agreements
               or similar agreements by which EMS is bound; and

          (iii)The  complete  and executed  License  Agreement  and the Research
               Agreement  and the Patents and the Patent  Applications  with all
               schedules,  exhibits  and  amendments  related  thereto  and  all
               material  correspondence  with the  patent  authorities  relating
               thereto have been provided to CENTREX; and

          (iv) There  are no  outstanding  licenses  to or  from  others  of any
               intellectual property and trade names; and

          (v)  There are no outstanding  contracts or commitments to sell, lease
               or otherwise dispose of any of the property of EMS.

     (p) Compliance  with Laws. EMS is in compliance  with all applicable  laws,
rules,  regulations  and  orders  promulgated  by any  federal,  state  or local
governmental  body or agency relating to its business and  operations.  EMS owns
all franchises,  licenses, permits, easements,  rights,  applications,  filings,
registration  and other  authorizations  which are  necessary  for it to conduct
business,  all of which are valid and in full  force and  effect,  and EMS is in
full compliance therewith.

     (q)   Litigation.   There  is  no  suit  or  action  or  any   arbitration,
administrative,  legal or other  proceeding  of any  kind or  character,  or any
governmental investigation pending or threatened against EMS or the Patents, the
Patent Applications,  the License or the Research Agreement affecting its assets
or business,  and there is no factual  basis  therefor.  There are no pending or
threatened actions or proceedings before any court, arbitrator or administrative
agency which would, if adversely  determined,  individually or in the aggregate,
materially and adversely affect its assets or business.

     (r) Employees.  EMS has no employees. EMS is not a party to or bound by any
employment agreement or any collective  bargaining agreement with respect to any
of the employees.



                                       -8-

                                                  Sequentially numbered page 151
<PAGE>


     (s) Employee Benefit Plans.  There are no employee benefit plans in effect,
and there are no outstanding or unfunded liabilities to employees of EMS.

     (t)  Books and  Records.  The books and  records  of EMS are  complete  and
accurate in all material  respects,  fairly present its business and operations,
have been maintained in accordance with good business practices,  and accurately
reflect  in  all  material  respects  its  business,   financial  condition  and
liabilities.

     (u) No Broker's  Fees.  Neither  UTEK nor EMS has  incurred  any  finder's,
broker's,  investment  banking,  financial,  advisory or other  similar  fees or
obligations.

     (v) Full Disclosure.  All representations or warranties of UTEK and EMS are
true, correct and complete in all material respects on the date hereof and shall
be true,  correct and complete in all material  respects as of the Closing as if
they were made on such date. No statement  made by EMS herein or in the exhibits
and schedules hereto or any document  delivered by EMS or on its behalf pursuant
to this  Agreement  contains an untrue  statement  of material  fact or omits to
state all material facts necessary to make the statements therein not misleading
in any material respect.

     2.02. General Representations and Warranties of CENTREX. CENTREX represents
and warrants to UTEK and EMS that the facts set forth are true and correct:

     (a) Organization. CENTREX is a corporation duly organized, validly existing
and in good standing under the laws of the State of Oklahoma, is qualified to do
business  as a  foreign  corporation  in each  other  jurisdiction  in which the
conduct  of  its  business  or the  ownership  of its  properties  require  such
qualification, and has all requisite power and authority to conduct its business
and operate properties.

     (b) Authorization.  The execution of this Agreement and the consummation of
the  Merger  and the  other  transactions  contemplated  hereby  have  been duly
authorized  by the Board of  Directors  and  Shareholders  of CENTREX;  no other
corporate  action  on its  part is  necessary  in  order  to  execute,  deliver,
consummate  and  perform its  obligations  hereunder;  and it has all  requisite
corporate  and other  authority  to  execute  and  deliver  this  Agreement  and
consummate the transactions contemplated hereby.

     (c)   Capitalization.   The  authorized  capital  of  CENTREX  consists  of
45,000,000  shares of common  stock,  par value $.00l per share,  of which up to
7,000,000 shares will be issued and outstanding  immediately after the Effective
Time,  and  5,000,000  shares of  Preferred  Stock,  none of which is issued and
outstanding.  All issued and outstanding  shares of common stock of CENTREX have
been duly and validly  issued and are fully paid and  non-assessable  shares and
have not been issued in violation of any preemptive or other rights of any other
person or any applicable laws. There will be no outstanding options, warrants,



                                       -9-

                                                  Sequentially numbered page 152
<PAGE>


commitments,  calls or other  rights  or  agreements  requiring  it to issue any
shares of CENTREX  common  stock or  securities  convertible  into shares of its
common stock to anyone for any reason whatsoever immediately after the Effective
Time.

     (d) Binding Effect. The execution,  delivery,  performance and consummation
of the Merger and the  transactions  contemplated  hereby  will not  violate any
obligation to which CENTREX is a party and will not create a default  hereunder;
and this Agreement constitutes a legal, valid and binding obligation of CENTREX,
enforceable  in  accordance  with its  terms,  except as the  enforcement  maybe
limited  by  bankruptcy,  insolvency,  moratorium,  or  similar  laws  affecting
creditor's  rights  generally  and by the  availability  of  injunctive  relief,
specific performance or other equitable remedies.

     (e) Litigation Relating to this Agreement.  There are no suits,  actions or
proceedings  pending  or to its  knowledge  threatened  which seek to enjoin the
Merger or the transactions contemplated by this Agreement or which, if adversely
decided,  would have a materially  adverse  effect on its  business,  results of
operations, assets, prospects or the results of its operations of CENTREX.

     (f) No Conflicting  Agreements.  Neither the execution and delivery of this
Agreement  nor the  fulfillment  of or  compliance  by CENTREX with the terms or
provisions hereof will result in a breach of the terms, conditions or provisions
of, or  constitute a default  under,  or result in a violation of, its corporate
charter or bylaws, or any agreement,  contract,  instrument,  order, judgment or
decree to which it is a party or by which it or any of the  assets is bound,  or
violate any  provision of any  applicable  law, rule or regulation or any order,
decree,  writ or injunction of any court or governmental entity which materially
affects its assets or business.

     (g) Consents. No consent from or approval of any court, governmental entity
or any other person is necessary in  connection  with its execution and delivery
of this  Agreement and  performance of the  obligations of CENTREX  hereunder or
under any other agreement to which CENTREX is a party;  and the  consummation of
the transactions contemplated by this Agreement will not require the approval of
any entity or person in order to prevent the  termination of any material right,
privilege, license or agreement relating to CENTREX or its assets or business.

     (h)  Title to Its  Assets.  CENTREX  has good and  marketable  title to its
assets (tangible and intangible),  free and clear of all charges, claims, liens,
mortgages, options, restrictions,  security agreements and other encumbrances of
every kind or nature whatsoever.

     (i)  Condition of Tangible  Assets.  All of its  tangible  assets have been
operated in accordance with customary operating  practices generally  acceptable
in its industry to which and have been  maintained and are in good working order
and repair in the ordinary  course of business,  subject only to reasonable  and
ordinary wear and tear.


                                      -10-

                                                  Sequentially numbered page 153
<PAGE>


     (j) Financial  Statements.  The unaudited  financial  statements of CENTREX
attached as Schedule 2.02(j) as of the Closing will present fairly its financial
position  and the  results of its  operations  on the dates and for the  periods
shown therein;  provided,  however that interim financial statements are subject
to customary year-end adjustments and accruals that, in the aggregate,  will not
have a material adverse effect on the overall financial  condition or results of
its  operations.  CENTREX has not engaged in any business  not  reflected in its
financial statements.  There have been no material adverse changes in the nature
of its business, prospects, the value of assets or the financial condition since
the date of its financial  statements.  There are no outstanding  obligations or
liabilities of CENTREX except as specifically set forth in the CENTREX financial
statements.

     (k) Taxes.  All returns,  reports,  statements  and other  similar  filings
required to be filed by it with respect to any federal,  state, local or foreign
taxes,  assessments,   interests,   penalties,   deficiencies,  fees  and  other
governmental  charges or impositions have been timely filed with the appropriate
governmental  agencies  in all  jurisdictions  in  which  such tax  returns  are
required to be filed;  all such tax returns  properly reflect all liabilities of
it for taxes for the periods, property or events covered thereby; and all taxes,
whether or not  reflected on those tax returns,  and all taxes claimed to be due
from it by any taxing  authority,  have been properly paid, except to the extent
it has contested in good faith by appropriate  proceedings and adequate reserves
have been  established  in its  financial  statements  to the full extent if the
contest is adversely  decided against it. CENTREX has not received any notice of
assessment or proposed  assessment in connection  with any tax returns.  CENTREX
has not extended or waived the  application of any statute of limitations of any
jurisdiction  regarding the assessment or collection of any taxes.  There are no
tax liens  (other  than any lien which  arises by  operation  of law for current
taxes not yet due and payable) on any of its assets. CENTREX has no knowledge of
any basis for any additional  assessment of taxes. CENTREX has made all deposits
required  by law to be made with  respect to  employees'  withholding  and other
employment  taxes,  including  without  limitation  the portion of such deposits
relating to taxes imposed upon it.

     (l) Absence of Certain Changes or Events.  CENTREX has not and, without the
written consent of EMS, it will not have:

          (i)  Sold,  encumbered,  assigned or  transferred  any of its material
               assets for less than fair consideration; or

          (ii) Amended or terminated any material agreement; or

          (iii) Suffered any material damage, destruction or loss; or

          (iv) Received notice or have knowledge of any material  adverse effect
               on its material assets; or


                                      -11-

                                                  Sequentially numbered page 154
<PAGE>


          (v)  Made any commitments or agreements for capital expenditures; or

          (vi) Entered into any transaction other than in the ordinary course of
               business consistent with past practice; or

          (vii)Agreed to take any of the actions set forth in this paragraph.


     (m)  Material  Contracts.  A complete  and  accurate  copy of all  material
agreements, contracts and commitments of the following types, whether written or
oral to which it is a party or is bound, has been provided to EMS:

          (i)  All material promissory notes,  mortgages,  indentures,  deeds of
               trust,  security  agreements and other agreements and instruments
               relating to the  borrowing of money by or any extension of credit
               to it; and

          (ii) All material operating agreements and lease agreements; and

          (iii)All  material  licenses  to or from  others  of any  intellectual
               property and trade names.

     (n)  Compliance  with Laws.  CENTREX is in compliance  with all  applicable
laws, rules,  regulations and orders promulgated by any federal,  state or local
governmental  body or agency  relating to its business and  operations.  CENTREX
owns  all  franchises,   licenses,  permits,  easements,  rights,  applications,
filings,  registration  and other  authorizations  which are necessary for it to
conduct business, all of which are valid and in full force and effect, and it is
in full compliance therewith.

     (o)   Litigation.   There  is  no   suit,   action   or  any   arbitration,
administrative,  legal or other  proceeding  of any  kind or  character,  or any
governmental investigation pending or threatened against it affecting its assets
or business,  and there is no factual  basis  therefor.  There are no pending or
threatened actions or proceedings before any court, arbitrator or administrative
agency which would, if adversely  determined,  individually or in the aggregate,
materially and adversely affect its assets or business.

     (p) Employees.  CENTREX has 4 employees.  CENTREX has no written agreements
with its employees.

     (q) Employee Benefit Plans and Arrangements.  There are no employee benefit
plans in effect, and there are no unfunded liabilities to employees.

     (r) Books and  Records.  The books and records of CENTREX are  complete and
accurate in all material  respects,  fairly present its business and operations,
have been

                                      -12-

                                                  Sequentially numbered page 155
<PAGE>


maintained in accordance with good business practices, and accurately reflect in
all material respects its business and financial condition.

     (s)  No  Broker's  Fees.  CENTREX  has  incurred  no  finder's,   broker's,
investment banking, financial,  advisory or other similar fee in connection with
this Agreement, except the fee payable to UTEK.

     (t) Full Disclosure. All representations or warranties of CENTREX are true,
correct and  complete in all  material  respects on the date hereof and shall be
true, correct and complete in all material respects as of the Closing as if they
were made on such date.  No  statement  made by it herein or in the exhibits and
schedules  hereto or any document  delivered by it or on its behalf  pursuant to
this Agreement  contains an untrue  statement of material fact or omits to state
all material facts  necessary to make the  statements  therein not misleading in
any material respect.

     2.03. Investment  Representations of UTEK Shareholders.  UTEK and Dr. Gross
each individually represents and warrants to CENTREX that:

     (a) General. It has such knowledge and experience in financial and business
matters as to be capable of evaluating  the risks and merits of an investment in
the shares  ("Shares")  of common  stock of  CENTREX  issuable  pursuant  to the
Merger.  It is able to bear the economic  risk of the  investment in the Shares,
including  the  risk  of a total  loss  of the  investment  in the  Shares.  The
acquisition of the Shares is for its own account and is for  investment.  Except
as permitted by law, it has a no present  intention of selling,  transferring or
otherwise  disposing  in  any  way of all or  any  portion  of the  Shares.  All
information that it has supplied to CENTREX in connection with this Agreement is
true and correct.  It  acknowledges  that an investment in the Shares involves a
very high degree of risk. It has conducted all  investigations and due diligence
concerning  CENTREX  which  it  deems  appropriate,  and it has  found  all such
information obtained fully acceptable.  It is knowledgeable about the prospects,
business, financial condition,  operations and possible acquisitions of CENTREX.
It has had an  opportunity  to ask  questions of the  officers and  directors of
CENTREX  concerning  the Shares and the business and financial  condition of and
prospects for CENTREX, and the officers and directors of CENTREX have adequately
answered  all  questions  asked  and made  all  relevant  information  requested
available  to it. It  understands  that  success of CENTREX  is  dependent  upon
CENTREX's  receipt of funds necessary to provide working capital,  which may not
occur. It understands and agrees that the following restrictions and limitations
are applicable to the purchase,  resale and  distribution of the Shares pursuant
to applicable securities laws.

     (b) Stock Transfer Restrictions.

          (i)  It is  aware  that it must  bear  the  full  economic  risk of an
               investment in the Shares of CENTREX for an  indefinite  period of
               time, because the transaction



                                      -13-

                                                  Sequentially numbered page 156
<PAGE>


               in which the  Shares  are being  issued  has not been  registered
               under the Securities Act of 1933, as amended  ("Securities Act"),
               or the securities laws of any state; and,  therefore,  the Shares
               cannot be sold,  pledged,  transferred  or otherwise  disposed of
               unless   registered  under  applicable   securities  laws  or  an
               exemption from registration is available.  It further understands
               that only CENTREX can take action to register the Shares, and the
               cost of registration is prohibitive.

          (ii) A legend  will be placed  on the  certificates  representing  the
               common stock of CENTREX in substantially the following form:


                             NOTICE OF TRANSFER RESTRICTIONS

     The shares  evidenced by this Certificate have been acquired for investment
only and have not been registered  under the Securities Act of 1933, as amended,
or the securities  laws of any state.  The Shares may not be sold,  transferred,
pledged or  otherwise  disposed  of without the receipt of an opinion of counsel
acceptable to CENTREX that no such registration is required.

          (iii)Stop  transfer   instructions   have  been  placed  in  CENTREX's
               transfer  records  with  respect to the Shares to insure that any
               transfer  or  disposition  thereof  is in  full  compliance  with
               applicable  law.  It  agrees  that  CENTREX  may  refuse or delay
               transfer  of the  Shares  or  impose  other  restrictions  on the
               transfer  of the  Shares if  CENTREX  is not  satisfied  that the
               transfer is lawful. However, CENTREX acknowledges and agrees that
               this  determination must be made within a reasonable time; and if
               CENTREX  finds the  transfer is  satisfactory  and  permitted  by
               applicable law, CENTREX will not refuse or delay the transfer.

                                   ARTICLE III
                          TRANSACTIONS PRIOR TO CLOSING

     3.01.  Corporate  Approvals.  Prior to Closing,  each of the parties  shall
submit this  Agreement to its Board of  Directors  and  Shareholders  and obtain
approval  thereof.  Copies of corporate  actions taken shall be provided to each
party.

     3.02.  Access to  Information.  Each party agrees to permit upon reasonable
notice  the  attorneys,  accountants,  and  other  representatives  of the other
parties reasonable access during normal business hours to its properties and its
books and records to make reasonable investigations with respect to its affairs,
and to make its officers and employees available to answer questions and provide
additional information as reasonably requested.



                                      -14-

                                                  Sequentially numbered page 157
<PAGE>


     3.03.  Expenses.  Each party agrees to bear its own expenses in  connection
with  the  negotiation  and  consummation  of the  Merger  and the  transactions
contemplated hereby.

     3.04. Covenants.  Except as permitted in writing, each party agrees that it
will:

          (i)  Use its good  faith  efforts to obtain  all  requisite  licenses,
               permits,  consents,  approvals  and  authorizations  necessary in
               order to consummate the Merger; and

          (ii) Notify the other  parties upon the  occurrence of any event which
               would have a  materially  adverse  effect  upon the Merger or the
               transactions  contemplated hereby or upon the business, assets or
               results of operations; and

          (iii)Not  modify  its  corporate  structure,  except as  necessary  or
               advisable in order to consummate the Merger and the  transactions
               contemplated hereby.

                                   ARTICLE IV
                              CONDITIONS PRECEDENT

     The obligation of the parties to consummate the Merger and the transactions
contemplated hereby are subject to the following  conditions which may be waived
to the extent permitted by law:

     (a) Each  party must  obtain the  approval  of its Board of  Directors  and
shareholders in accordance with applicable law, and such approval shall not have
been rescinded or restricted; and

     (b) Each party shall  obtain all  requisite  licenses,  permits,  consents,
authorizations   and   approvals   required  to  complete  the  Merger  and  the
transactions contemplated hereby; and

     (c) There shall be no effective injunction, writ or preliminary restraining
order or other  order of a similar  nature  issued by any court or  governmental
agency  having  jurisdiction  directing  that  the  Merger  or the  transactions
contemplated hereby shall not be consummated; and

     (d) The  representations  and  warranties  of the parties shall be true and
correct in all material respects at the Effective Time; and

     (e) CENTREX shall pay EMS the following amounts:


                                      -15-

                                                  Sequentially numbered page 158
<PAGE>


          (1)  Initial  License  Fee  of  $7,000,  payable  to UC  on or  before
               Closing; and

          (2)  Up-Front Annual License Fee of $2,500, payable to UC on or before
               January 1, 2000; and

          (3)  Initial Research Fee of $70,000 pursuant to the Funds In Research
               Agreement, payable to UC on or before Closing.

     (f) CENTREX shall enter into a Consulting Agreement with UTEK.

     (g) The  Patents  are valid and in full  force and  effect;  and the Patent
Applications have been prosecuted in good faith with reasonable diligence.

     (h) The Research  Agreement is valid and in full force and effect and there
has been no default therein; and

     (i) The License is valid and in full force and effect and there has been no
default therein.

     (j) The Inventor has entered  into a Consulting  Agreement  with CENTREX in
mutually  agreed  form and  substance  which  provides  that Dr.  Castro will be
available to provide  consulting  services and technical  advice to CENTREX from
time to time about the Invention, so long as such advice and consulting services
do not unreasonably interfere with his duties and responsibilities with LANL and
UC.


                                    ARTICLE V
                                 INDEMNIFICATION

     (a) By UTEK. UTEK agrees to indemnify, defend and hold harmless CENTREX and
its shareholders, directors, officers, employees, agents and representatives and
their  respective  successors  and  assigns  against and in respect of any cost,
damage, expense (including reasonable legal fees and actual expenses), liability
or loss  incurred or suffered  by any of them  resulting  from or arising out of
the: (i) breach, inaccuracy,  misrepresentation or untruth of any representation
or  warranty,  or the  nonfulfillment  of any  agreement  or  covenant  of  UTEK
contained  in this  Agreement  or in any  document  delivered  by UTEK or EMS to
CENTREX  pursuant  hereto;  and  (ii) any  action,  assessment,  claim,  demand,
proceeding  or suit  incident to any of the  foregoing.  The  liability  of UTEK
hereunder may be satisfied by the return to CENTREX of shares of CENTREX  common
stock  issued  pursuant  hereto  valued at the fair market value on the date the
breach is discovered to the extent of the breach.


                                      -16-

                                                  Sequentially numbered page 159
<PAGE>


     (b) By CENTREX. CENTREX agrees to indemnify,  defend and hold harmless UTEK
and its member, managers,  officers,  employees,  agents and representatives and
their  respective  successors  and  assigns  against and in respect of any cost,
damage, expense (including reasonable legal fees and actual expenses), liability
or loss  incurred or suffered by any of them  resulting  from or arising out of:
(i) the breach, inaccuracy,  misrepresentation or untruth of any representation,
warranty,  or the  nonflilfillment  of any  agreement  or  covenant  of  CENTREX
contained in this Agreement or in any document  delivered by it to UTEK pursuant
hereto;  and (ii) any action,  assessment,  claim,  demand,  proceeding  or suit
incident to any of the foregoing.

     (c) Costs.  The  indemnification  rights and  obligations of a party hereto
shall  include  the  right  to  receive  and the duty to pay and  reimburse  the
indemnified  party  all  its  reasonable  costs  and  expenses  incurred  in the
enforcement of its rights hereunder.

     (d) Survival of Representations and Warranties.

                  (1) The  representations  and  warranties  made by UTEK  shall
survive  for a  period  of 3  years  after  Closing,  and  thereafter  all  such
representations  and warranties  shall be  extinguished,  except with respect to
claims then pending for which specific  notice has been given during such 3 year
period.   UTEK  shall  have  liability  and  responsibility  for  the  surviving
representations  and  warranties  made  by it  herein,  notwithstanding  any due
diligence investigation or examination by CENTREX.

                  (2) The  representations  and warranties made by CENTREX shall
survive  for a  period  of 3  years  after  Closing,  and  thereafter  all  such
representations  and warranties  shall be  extinguished,  except with respect to
claims then pending for which specific  notice has been given during such 3 year
period.  CENTREX  shall have  liability  and  responsibility  for the  surviving
representations  and  warranties  made  to  CENTREX,   notwithstanding  any  due
diligence investigation or examination by UTEK.

     (e) Limitations on Liability. Notwithstanding any other provision herein to
the  contrary,  neither  party hereto shall be liable to the other party for any
cost, damage,  expense,  liability or loss under this indemnification  provision
until  after the sum of all  amounts  individually  when added to all other such
amounts in the aggregate  exceeds $500, and then such liability shall apply only
to matters in excess of $500.

     (f)  Rights  of  Indemnitors.   The  indemnified  party  shall  notify  the
indemnifying  party of the assertion or  commencement  of such action,  claim or
proceeding  within a  reasonable  period of time or, if  citation  or service of
process has been made, within 15 days thereafter.  The indemnified party may, at
its option and at its sole  expense,  participate  in the defense of and contest
any such action, claim or proceeding;  provided,  however, the indemnified party
shall at all times  also have the right to  participate  fully  therein.  If the
indemnifying party, within a reasonable time after receiving such notice,  fails
to participate,

                                      -17-

                                                  Sequentially numbered page 160
<PAGE>


the  indemnified  party  shall have the right,  but shall not be  obligated,  to
undertake the defense of the action,  claim or proceeding for the account of and
at the risk of the indemnifying party; provided,  however, in the event that the
indemnified  party shall  determine  to  compromise  or settle  (exercising  its
judgment in good faith) any such action,  claim or proceeding,  the  indemnified
party shall be required to give the  indemnifying  party 15 days' notice of such
determination  after its receipt of actual notice of the claim.  The indemnified
party  shall then be  entitled  to  compromise  or settle the  action,  claim or
proceeding  for  the  account  of and at the  risk  of the  indemnifying  party;
provided, however, the settlement shall be effective without the consent of both
the indemnifying and indemnified parties,  which consent shall not be reasonably
withheld. The parties agree that any indemnified party may join any indemnifying
party in any action,  claim or proceeding  brought by a third party, as to which
any right of indemnity  created by this Agreement would or might apply,  for the
purpose of  enforcing  any right of the  indemnity  granted to such  indemnified
party pursuant to this Agreement.

     (g) Additional Rights. Any right of indemnity of any party pursuant to this
Agreement  shall be in addition to and shall not operate as a limitation  on any
other right to indemnity of such party pursuant to this Agreement,  any document
or instrument  executed in connection  with the  consummation of the transaction
contemplated hereby or otherwise.

                                   ARTICLE VI
                                   ARBITRATION

     In the event a dispute arises with respect to the  interpretation or effect
of this Agreement or concerning the rights or obligations of the parties hereto,
the parties  agree to  negotiate in good faith with  reasonable  diligence in an
effort to resolve the dispute in a mutually acceptable manner.  Failing to reach
a resolution thereof, either party shall have the right to submit the dispute to
be settled by  arbitration  under the  Commercial  Rules of  Arbitration  of the
American Arbitration Association.  The parties agree that all arbitrations shall
be  conducted  in Tulsa,  Oklahoma,  unless the  parties  mutually  agree to the
contrary.  The cost of arbitration  shall be borne by the party against whom the
award is rendered or, if in the interest of fairness, as allocated in accordance
with the judgment of the  arbitrators.  All awards in  arbitration  made in good
faith  and not  infected  with  fraud or  other  misconduct  shall be final  and
binding.

                                   ARTICLE VII
                                  MISCELLANEOUS

     No party  may  assign  this  Agreement  or any  right or  obligation  of it
hereunder  without the prior  written  consent of the other parties  hereto.  No
permitted  assignment  shall  relieve  a party  of its  obligations  under  this
Agreement  without  the  separate  written  consent of the other  parties.  This
Agreement  shall be binding  upon and enure to the  benefit of the  parties  and
their  respective  permitted  successors and assigns.  Each party agrees that it
will comply


                                      -18-

                                                  Sequentially numbered page 161
<PAGE>


with all applicable laws, rules and regulations in the execution and performance
of its obligations under this Agreement. This Agreement shall be governed by and
construed in  accordance  with the laws of the State of Oklahoma  This  document
constitutes a complete and entire  agreement among the parties with reference to
the  subject  matters set forth  herein.  No  statement  or  agreement,  oral or
written, made prior to or at the execution hereof and no prior course of dealing
or  practice  by either  party  shall vary or modify the terms set forth  herein
without the prior consent of the other  parties  hereto.  This  Agreement may be
amended  only by a written  document  signed by the  parties.  Notices  or other
communications  required to be made in connection  with this Agreement  shall be
delivered to the parties at the address set forth below or at such other address
as may be  changed  from  time to time by  giving  written  notice  to the other
parties. This Agreement may be executed in multiple counterparts,  each of which
shall constitute one and a single Agreement.



                                  ARTICLE VIII
                          PIGGYBACK REGISTRATION RIGHTS

     CENTREX  covenants  and  agrees  that if it files with the  Securities  and
Exchange Commission an underwritten  registration statement on SEC Form S-SB1 or
Form  S-1 or its  equivalent  which  includes  the  offer  of  shares  owned  by
shareholders  of CENTREX,  CENTREX  will use its best efforts to include some or
all of the  shares  of  CENTREX  common  stock  issued  to and then held by UTEK
pursuant to this Agreement.  If the underwriters include any selling shareholder
shares,  UTEK shall be permitted to include some or all of its CENTREX shares on
a pro rata basis to the extent and upon the same terms and  conditions  as other
CENTREX  shareholders are permitted to have their CENTREX shares included in the
proposed  offering.  If the  underwriters  do not  permit  for  any  reason  the
inclusion of selling shareholder shares in the offering,  UTEK shares shall also
not be included. It is the expressed intent of this Article that UTEK be treated
exactly the same as any other selling CENTREX shareholder in connection with any
underwritten  offering  of CENTREX  common  stock,  no better  and no worse.  If
CENTREX proposes an underwritten offering, CENTREX will give UTEK 15 days' prior
written  notice  thereof,  and UTEK shall  give  CENTREX  notice  within 10 days
thereafter  of UTEK's  desire  as to the  number of  shares,  if any,  that UTEK
desires to include in the offering. CENTREX will notify the lead underwriters of
UTEK's  desire,  and CENTREX will include  UTEK shares in  accordance  with this
Article. As a condition of including any UTEK shares in the offering, UTEK shall
(1) sign all underwriting agreements, representations,  warranties, certificates
and  other  papers  as the  underwriters  require  of  UTEK  and  other  CENTREX
shareholders  whose shares are to be included in the offering;  (2) pay pro rata
all  costs  of  the  offering  to the  same  extent  as  other  CENTREX  selling
shareholders  are  required  to pay;  and (3) take all other  actions and do all
other things as are required of other selling  shareholders.  Failure of UTEK to
respond  within  10  days  after  notice  of  CENTREX's  intention  to  file  an
underwritten  offering shall constitute a waiver of the rights set forth in this
Article.

                                      -19-

                                                  Sequentially numbered page 162
<PAGE>



     IN WITNESS  WHEREOF,  the parties  have caused  this  Agreement  to be duly
executed by a duly authorized officer this ________ day of March, 1999.



CENTREX, INC.                                   E.COLI MEASUREMENT SYSTEMS,
                                                INC.

By:/ s /  Gifford M. Mabie                      By:/ s /  Clifford M Gross
__________________________                      ________________________________
Gifford M. Mabie, CEO                           Dr. Clifford M. Gross, President

                                                UTEK, LLC

/ s /  Clifford M. Gross                        By:/ s /  Clifford M. Gross
__________________________                      ________________________________
Dr. Clifford M. Gross, Individually as to       Dr. Clifford M. Gross, Chief
Paragraph 2.03 only                             Executive Officer




                                      -20-

                                                  Sequentially numbered page 163
<PAGE>


                              CERTIFICATE OF MERGER


TO THE  SECRETARY OF STATE OF THE STATE OF OKLAHOMA,  101 State  Capitol  Bldg.,
Oklahoma City, OK 73105.

     This  Certificate  of Merger is being filed pursuant to Section 1082 of the
Oklahoma General  Corporation  Act. In lieu of filing an executed  Agreement and
Plan of  Merger,  the  Surviving  Corporation  hereby  states and  certifies  as
follows:

1.   The  names  and  states  of   incorporation  of  each  of  the  Constituent
     Corporations are:

     NAME OF CORPORATION                          STATE OF INCORPORATION

     Centrex, Inc.                                Oklahoma
     E.coli Measurement System, Inc.              Florida

2.   An  Agreement  and Plan of Merger has been  approved,  adopted,  certified,
     executed and  acknowledged by each Constituent  Corporation,  in accordance
     with the  provisions  of Section 1082 of Title 18 of the Oklahoma  Statutes
     and Section 601.1107 of the Corporation Laws of Florida.

3.   The name of the Surviving Corporation is Centrex, Inc.

4    The Certificate of Incorporation of the Surviving  Corporation is not being
     changed by reason of the Merger.

5.   The executed Agreement and Plan of Merger is on file at the principal place
     of business of the Surviving Corporation at 8908 S. Yale, Suite 409, Tulsa,
     OK 74137-3545.

6.   A copy of the Agreement and Plan of Merger will be furnished on request and
     without cost to any shareholder of any Constituent Corporation.

7.   The authorized capital of E.coli Measurement  System,  Inc. is 1,000 shares
     of common  stock,  par value $1.00 per share,  and 1,000 shares are issued,
     outstanding and voted for the Merger.



                                        1

                                                  Sequentially numbered page 164
<PAGE>


                                    Exhibit B
                                       to
                          Agreement and Plan of Merger



                                    Directors

                                Gifford M. Mabie
                                Rhonda R. Vincent



                                    Officers

              Gifford M. Mabie                President and CEO
              Rhonda R. Vincent               Vice President and CFO
              Frederick K. Slicker            Vice President and General Counsel
              Thomas Coughlin, M.D            Vice President
              Rhonda R. Vincent               Treasurer
              Rhonda R. Vincent               Secretary

                                                  Sequentially numbered page 165
<PAGE>


                                   SCHEDULE 1

                                 PATENT POSITION

o    US Provisional  Patent  No._______  dated December 18, 1998 under the title
     "Method for the Detection of Specific  Nucleic Acid Sequences by Polymerase
     Nucleotide Incorporation"

o    Canadian Patent No.______ dated _______

o    Pending Patents: None



                                                  Sequentially numbered page 166


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