ROSETTA INPHARMATICS INC
4/A, 2000-09-21
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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--------                                  UNITED STATES SECURITIES AND EXCHANGE COMMISSION             -----------------------------
 FORM 4                                                WASHINGTON, D.C. 20549                                   OMB APPROVAL
--------                                                                                               -----------------------------
/ / CHECK THIS BOX IF NO                    STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP                OMB NUMBER:       3235-0287
    LONGER SUBJECT TO                                                                                   EXPIRES: SEPTEMBER 30, 1998
    SECTION 16.  FORM 4 OR    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,   ESTIMATED AVERAGE BURDEN
    FORM 5 OBLIGATIONS MAY       Section 17(a) of the Public Utility Holding Company Act of 1935 or     HOURS PER RESPONSE .... 0.5
    CONTINUE.  SEE                       Section 30(f) of the Investment Company Act of 1940           -----------------------------
    INSTRUCTION 1(b).
(Print or Type Responses)
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<S><C>
1. Name and Address of Reporting Person*     2. Issuer Name AND Ticker or Trading Symbol     6. Relationship of Reporting Person(s)
                                                                                                 to Issuer (Check all applicable)
                                                                                                X   Director             10% Owner
   Buffington     William          I.           ROSETTA INPHARMATICS, INC. (RSTA)              ----                 ----
---------------------------------------------------------------------------------------------       Officer (give        Other
    (Last)        (First)        (Middle)    3. IRS or Social Security  4. Statement for       ----          title  ---- (specify
                                                Number of Reporting        Month/Year                        below)       below
                                                Person (Voluntary)                            -------------------------------------
   395 PAGE MILL ROAD, M/S A3-18                                           August 2000
--------------------------------------------                            --------------------- 7. Individual or Joint/Group Filing
                  (Street)                                              5. If Amendment,          (Check Applicable Line)
                                                                           Date of Original    X  Form filed by One Reporting Person
                                                                           (Month/Year)       ---
                                                                                                  Form filed by More than One
   PALO ALTO,      CA               94306                                   09/11/00          --- Reporting Person
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    (City)       (State)            (Zip)        TABLE I - NON-DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY OWNED
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1. Title of Security               2. Trans-   3. Trans-     4. Securities Acquired (A)    5. Amount of     6. Owner-   7. Nature
   (Instr. 3)                         action      action        or Disposed of (D)            Securities       ship        of In-
                                      Date        Code          (Instr. 3, 4 and 5)           Beneficially     Form:       direct
                                                  (Instr. 8)                                  Owned at         Direct      Bene-
                                     (Month/                                                  End of           (D) or      ficial
                                      Day/     -------------------------------------------    Month            Indirect    Owner-
                                      Year)                               (A) or                               (I)         ship
                                                Code    V       Amount    (D)     Price       (Instr. 3        (Instr. 4) (Instr. 4)
                                                                                              and 4)
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COMMON STOCK                         8/08/00     C             2,285,714    A                 2,285,714          I   Held by Agilent
                                                                                                                     Technologies,
                                                                                                                     Inc. (2)
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COMMON STOCK                         8/08/00     C               459,792    A                   459,792          I   Held by Agilent
                                                                                                                     Technologies,
                                                                                                                     Inc. (2)
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COMMON STOCK                         8/08/00     X               714,285    A      $14.00       714,285 (1)      I   Held by Agilent
                                                                                                                     Technologies,
                                                                                                                     Inc. (2)
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Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.                   (Over)
* If the form is filed by more than one reporting person, SEE Instruction 4(b)(v).                                   SEC 1474 (7-97)

                              POTENTIAL PERSONS WHO ARE TO RESPOND TO THE COLLECTION OF INFORMATION
                              CONTAINED IN THIS FORM ARE NOT REQUIRED TO RESPOND UNLESS THE FORM
                              DISPLAYS A CURRENTLY VALID OMB CONTROL NUMBER.

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<CAPTION>

FORM 4 (CONTINUED)          TABLE II - DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY OWNED
                                   (E.G., PUTS, CALLS, WARRANTS, OPTIONS, CONVERTIBLE SECURITIES)

------------------------------------------------------------------------------------------------------------------------
1. Title of Derivative Security     2. Conver-   3. Trans-   4. Transac-   5. Number of Deriv-      6. Date Exer-
   (Instr. 3)                          sion or      action      tion Code     ative Securities Ac-     cisable and Ex-
                                       Exercise     Date        (Instr. 8)    quired (A) or Dis-       piration Date
                                       Price of    (Month/                    posed of (D)             (Month/Day/
                                       Deriv-       Day/                      (Instr. 3, 4, and 5)     Year)
                                       ative        Year)
                                       Security

                                                                                                    --------------------

                                                                                                     Date      Expira-
                                                             --------------------------------------  Exer-     tion
                                                                                                     cisable   Date
                                                              Code    V        (A)        (D)
<S><C>
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SERIES D PREFERRED STOCK                 1:1        08/08/00    C            2,285,714               Immed
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SERIES E PREFERRED STOCK                 1:1        08/08/00    C              459,792               Immed
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Put Options (obligation to buy)          $14.00     08/08/00    X              714,285               08/08/00   08/08/00
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<CAPTION>

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7. Title and Amount of Under-       8. Price   9. Number     10. Owner-     11. Nature
   lying Securities                    of         of Deriv-      ship           of In-
   (Instr. 3 and 4)                    Deriv-     ative          Form           direct
                                       ative      Securi-        of De-         Bene-
                                       Secur-     ties           rivative       ficial
                                       ity        Bene-          Secu-          Own-
                                       (Instr.    ficially       rity:          ership
                                       5)         Owned          Direct         (Instr. 4)
                                                  at End         (D) or
                     Amount or                    of             Indi-
       Title         Number of                    Month          rect (I)
                     Shares                       (Instr. 4)     (Instr. 4)
<S><C>
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Common Stock        2,285,714                        0              I      Held by Agilent
                                                                           Technologies,
                                                                           Inc. (2)
------------------------------------------------------------------------------------------
Common Stock          459,792                        0              I      Held by Agilent
                                                                           Technologies,
                                                                           Inc. (2)
------------------------------------------------------------------------------------------
Common Stock          714,285 (1)                    0              I      Held by Agilent
                                                                           Technologies,
                                                                           Inc. (2)
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Explanation of Responses:

(1) On August 8, 2000, pursuant to a put right exercised by the issuer, Agilent Technologies, Inc. purchased
    714,285 shares of the issuer's common stock at $14.00 per share, the actual initial public offering price.

(2) Mr. Buffington is the General Manager of Bioscience of Agilent Technologies, Inc. Mr. Buffington disclaims
    beneficial ownership of shares held by Agilent Technologies, Inc. except to the extent of his pecuniary
    interest therein.


                                                                                        /s/ John W. Robertson           9/21/2000
                                                                                  -----------------------------------  -----------
**Intentional misstatements or omissions of facts constitute                            Attorney In Fact for              Date
  Federal Criminal Violations.  SEE 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).              William I. Buffington

Note: File three copies of this Form, one of which must be manually signed.
      If space is insufficient, SEE Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained
in this form are not required to respond unless the form displays a currently
valid OMB Number.
                                                                                                                              Page 2
                                                                                                                     SEC 1474 (7-97)
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                              POWER OF ATTORNEY

     The undersigned hereby constitutes and appoints Stephen H. Friend, John
J. King, II, Gregory Sessler, and John W. Robertson, and each of them, his
or her true and lawful attorney-in-fact to:

     (1)     execute for and on behalf of the undersigned, in the
undersigned's capacity as an officer, director, and/or person who holds more
than 10% of the stock of Rosetta Inpharmatics, Inc. (the "COMPANY"), Forms 3,
Forms 4 and Forms 5 in accordance with Section 16(a) of the Securities
Exchange Act of 1934, as amended (the "EXCHANGE ACT"), and the rules
thereunder;

     (2)     do and perform any and all acts for and on behalf of the
undersigned which may be necessary or desirable to complete and execute any
such Forms 3, Forms 4 or Forms 5 and timely file any such forms with the
United States Securities and Exchange Commission and any other authority; and

     (3)     take any other action of any type whatsoever in connection with
the foregoing which, in the opinion of such attorney-in-fact, may be of
benefit to, in the best interest of, or legally required by, the undersigned,
it being understood that the documents executed by such attorney-in-fact on
behalf of the undersigned, pursuant to this Power of Attorney shall be in
such form and shall contain such terms and conditions as such
attorney-in-fact may approve in his or her discretion.

     The undersigned hereby grants to each such attorney-in-fact full power
and authority to do and perform any and every act and thing whatsoever
requisite, necessary or proper to be done in the exercise of any of the
rights and powers herein granted, as fully to all intents and purposes as the
undersigned might or could do if personally present, with full power of
substitution or revocation, hereby ratifying and confirming all that such
attorney-in-fact, or his or her substitute or substitutes, shall lawfully do
or cause to be done pursuant to this power of attorney. The undersigned
acknowledges that the foregoing attorneys-in-fact, in serving in such
capacity at the request of the undersigned, are not assuming, nor is the
Company assuming, any of the undersigned's responsibilities to comply with
Section 16 of the Exchange Act.

     This Power of Attorney shall remain in full force and effect from
September 11, 2000 through September 22, 2000 with respect to the
undersigned's holdings of and transactions in securities issued by the
Company, unless earlier revoked by the undersigned in a signed writing
delivered to the attorneys-in-fact.


                                       /s/ William I. Buffington
                                       ---------------------------------------
                                       William I. Buffington




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