BIOMEDICINES INC
S-1, EX-10.10, 2000-11-03
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                                                                   Exhibit 10.10


                                 AMENDMENT NO. I
                                       TO
                           MARINA VILLAGE OFFICE LEASE


THIS AMENDMENT NO. 1 TO MARINA VILLAGE OFFICE LEASE is made and entered into as
of June 1, 1999, by and between ALAMEDA REAL ESTATE INVESTMENTS, a California
limited partnership ("Landlord") and BIOMEDICINES, INC., a Delaware corporation,
("Tenant").

Landlord and Tenant have previously entered into that certain Marina Village
Office Lease dated December 1, 1998, (the "Lease") with respect to certain
premises located in 1301 Marina Village Parkway, Suite 200, Alameda, California.
Landlord and Tenant now desire to amend the lease as hereinafter provided and,
accordingly, Landlord and Tenant hereby agree as follows (unless otherwise
defined, all capitalized terms used in this Amendment shall have the same
meanings as set forth in the Lease):

1.       AMENDMENT OF BASIC LEASE INFORMATION. The following provisions of the
         Basic Lease information are hereby amended to read as follows:

<TABLE>
<S>                                       <C>                                                <C>
          TERM EXPIRATION:                  Apri1 30, 2004
          BASE RENT:                        May 1, 1999 - April 30, 2000                       $10,509/month
                                            May 1, 2000 - April 30, 2001                       $10,785/month
                                            May 1, 2001 - April 30, 2002                       $11,062/month
                                            May 1, 2002 - April 30, 2003                       $11,339/month
                                            May 1, 2003 - April 30, 2004                       $11,615/month

          SECURITY DEPOSIT:                 $37610.80
</TABLE>


2.       RATIFICATION. Landlord and Tenant hereby ratify and confirm all of the
         terms of the Lease as modified by paragraph 1 above. Except as
         expressly set forth to the contrary in this Amendment, the Lease, as
         amended, remains unmodified and in full force and effect. To the extent
         of any conflict between the terms of this Amendment and terms of the
         Lease, the terms of this Amendment shall control.


                                       1.
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IN WITNESS WHEREOF, Landlord and Tenant have executed this Amendment No. 1 as of
the date first set forth above.

<TABLE>
TENANT:                                           LANDLORD:


<S>                                               <C>
BIOMEDICINES, INC.,                               ALAMEDA REAL ESTATE INVESTMENTS,
a Delaware corporation                            a California limited partnership

                                                  By:      Vintage Alameda Investments, LP
                                                           a California limited partnership,
                                                           operating general partner

                                                  By:      Vintage Properties - Alameda Commercial,
                                                           a California corporation,
                                                           managing general partner

By:                                               By:
   --------------------------------                  -------------------------------
Title:            CEO                             Title:         President
      -----------------------------                     ----------------------------
</TABLE>


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