INFORMAX INC
S-1/A, EX-5.1, 2000-09-27
COMPUTER PROGRAMMING SERVICES
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                               September 26, 2000

Board of Directors
InforMax, Inc.
6010 Executive Blvd., 10th Floor
Rockville, MD  20852

Ladies and Gentlemen:

                  We are acting as special counsel to InforMax, Inc., a Delaware
corporation  (the "COMPANY"),  in connection with its registration  statement on
Form S-1, as amended (the "REGISTRATION  STATEMENT"),  filed with the Securities
and  Exchange  Commission  relating  to the  proposed  public  offering of up to
5,750,000  shares of the Company's common stock, par value $0.001 per share, all
of which  shares (the  "SHARES")  are to be sold by the  Company.  This  opinion
letter  is  furnished  to you at your  request  to  enable  you to  fulfill  the
requirements of Item 601(b)(5) of Regulation S-K, 17 C.F.R.  ss.  229.601(b)(5),
in connection with the Registration Statement.

                  For purposes of this opinion  letter,  we have examined copies
of the following documents:

                  1.       An executed copy of the Registration Statement.

                  2.       The Second Restated  Certificate of  Incorporation of
                           the Company,  as  certified  by the  Secretary of the
                           State of the State of Delaware on August 16, 2000 and
                           the  Restated  Certificate  of  Incorporation  to  be
                           effective  immediately  prior to the  closing  of the
                           offering,  each as certified by the  Secretary of the
                           Company  on  the  date  hereof  as  being   complete,
                           accurate, and in effect.

                  3.       The Second  Restated  Bylaws of the  Company  and the
                           Restated Bylaws to be effective  immediately prior to
                           the  closing of the  offering,  as  certified  by the
                           Secretary  of the Company on the date hereof as being
                           complete, accurate, and in effect.

                  4.       The proposed form of Underwriting Agreement among the
                           Company  and the  several  Underwriters  to be  named
                           therein,  for whom Bear,  Stearns & Co. Inc. will act
                           as  representative,  filed  as  Exhibit  1.1  to  the
                           Registration     Statement     (the     "UNDERWRITING
                           AGREEMENT").

                  5.       Resolutions  of the Board of Directors of the Company
                           adopted at  meetings  held on June 7, 2000,  July 19,
                           2000,  August 14,  2000 and  September  8,  2000,  as
                           certified by the Secretary of the Company on the date
                           hereof as being  complete,  accurate,  and in effect,
                           relating to the  issuance  and sale of the Shares and
                           arrangements in connection therewith.
<PAGE>

InforMax, Inc.
September 26, 2000
Page 2



                  In our examination of the aforesaid documents, we have assumed
the  genuineness of all signatures,  the legal capacity of all natural  persons,
the accuracy and completeness of all documents submitted to us, the authenticity
of all original documents, and the conformity to authentic original documents of
all documents  submitted to us as copies  (including  telecopies).  This opinion
letter is given,  and all  statements  herein  are made,  in the  context of the
foregoing.

                  This  opinion  letter is based as to  matters of law solely on
the Delaware General  Corporation Law, as amended.  We express no opinion herein
as to any other laws,  statutes,  ordinances,  rules,  or  regulations.  As used
herein,  the term "Delaware  General  Corporation Law, as amended"  includes the
statutory  provisions  contained  therein,  all  applicable  provisions  of  the
Delaware Constitution and reported judicial decisions interpreting these laws.

                  Based upon, subject to and limited by the foregoing, we are of
the opinion  that  following  (i)  execution  and delivery by the Company of the
Underwriting Agreement, (ii) effectiveness of the Registration Statement,  (iii)
issuance of the Shares pursuant to the terms of the Underwriting Agreement,  and
(iv) receipt by the Company of the consideration for the Shares specified in the
resolutions  of the Board of Directors and the Pricing  Committee  thereof,  the
Shares will be validly issued, fully paid, and nonassessable.

                  This  opinion  letter  has  been  prepared  for  your  use  in
connection with the Registration  Statement and speaks as of the date hereof. We
assume no obligation to advise you of any changes in the foregoing subsequent to
the delivery of this opinion letter.

                  We hereby  consent  to the  filing of this  opinion  letter as
Exhibit 5.1 to the  Registration  Statement  and to the  reference  to this firm
under the caption "Legal  Matters" in the prospectus  constituting a part of the
Registration  Statement. In giving this consent, we do not thereby admit that we
are an "expert" within the meaning of the Securities Act of 1933, as amended.

                                             Very truly yours,




                                             /s/ HOGAN & HARTSON L.L.P.




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