INFORMAX INC
424B1, 2000-10-03
COMPUTER PROGRAMMING SERVICES
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                                                FILED PURSUANT TO RULE 424(B)(1)
                                                           FILE NUMBER 333-41194


                               5,000,000 SHARES

                               [GRAPHIC OMITTED]

                                  COMMON STOCK

                              ------------------

     This  is  an initial public offering of 5,000,000 shares of common stock of
InforMax,  Inc.  We  are selling all of the shares of common stock offered under
this prospectus.

     Our  common  stock  has  been  approved  for listing on the Nasdaq National
Market under the symbol "INMX."

     SEE  "RISK FACTORS" BEGINNING ON PAGE 9 TO READ ABOUT RISKS THAT YOU SHOULD
CONSIDER BEFORE BUYING SHARES OF OUR COMMON STOCK.

     NEITHER  THE  SECURITIES  AND  EXCHANGE COMMISSION NOR ANY OTHER REGULATORY
BODY  HAS  APPROVED OR DISAPPROVED THESE SECURITIES OR PASSED ON THE ADEQUACY OR
ACCURACY  OF  THIS  PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL
OFFENSE.

                              ------------------

<TABLE>
<CAPTION>
                                                     PER SHARE         TOTAL
                                                    -----------   --------------
<S>                                                 <C>           <C>
Public offering price ...........................     $ 16.00      $80,000,000
Underwriting discounts and commissions ..........     $  1.12      $ 5,600,000
Proceeds to InforMax, Inc. ......................     $ 14.88      $74,400,000
</TABLE>

                              ------------------

     We  have  granted  the  underwriters  a  30-day option to purchase up to an
additional  750,000  shares  of  common  stock  from  us  at  the initial public
offering price less the underwriting discount.

     The  underwriters  are severally underwriting the shares being offered. The
underwriters  expect  to  deliver the shares in New York, New York on October 6,
2000.

                              ------------------

BEAR, STEARNS & CO. INC.

                           U.S. BANCORP PIPER JAFFRAY

                                                   ADAMS, HARKNESS & HILL, INC.

                 The date of this prospectus is October 2, 2000
<PAGE>

[At  the  top  of  the page of the inside front cover appears numerous series of
the  letters  "C,"  "A,"  "G"  and  "T"  in varied order, size, shade and color,
including  red, blue, green and white. The letters are surrounded by and overlay
various  numbers,  preceded  by  "+" signs. The numbers and letters appear as if
they  are  rapidly  moving  horizontally  across  the  page. Beneath the graphic
appears the caption, "From Data to Knowledge."]

[The  bottom  third  of  the  page  along  the  right  side begins with the word
"InforMax"  in  black  and  InforMax's  greenish-blue,  Double Helix Logo Design
above "High-Throughput Research(TM)."

[Along  the  top  left  third  of  the inside two-page gatefold appears numerous
series  of  the  letters  "C," "A," "G" and "T" in varied order, size, shade and
color,  including  red, blue, green and white. The letters are surrounded by and
overlay  various  numbers, preceded by "+" signs. The numbers and letters appear
as  if they are rapidly moving horizontally across the page. Running through the
middle  of  the  graphic  is a green horizontal line with various vertical lines
branching  out  above  and  below the horizontal line. The vertical lines end in
bullets  with  the  following  words appearing next to the bullets, from left to
right  alternatively  above  and  below  the  green  horizontal  line: "Customer
Databases,"  "Online  Data," "Integration of Data Types," "Our ResearchLogic(TM)
Interface,"  "Java  Framework,"  "Analysis,"  "Customized Data Presentation" and
"Collaboration."  Perpendicular  to  the  green horizontal line, at the far left
end  of  the  graphic above the green horizontal line is the word "Input" in red
font  with  an  arrow  pointing  to the phrase "Experimental Data" preceded by a
blue  bullet  appearing  below  the  green horizontal line. Perpendicular to the
green  horizontal  line,  at  the  far  right end of the graphic above the green
horizontal  line  is  the  word  "Results" in red font with an arrow pointing to
"Knowledge,"  "Productivity,"  and  "Products,"  each  preceded by a blue bullet
appearing below the green horizontal line.]

[Along  the  bottom  two thirds of the two page gatefold on the left side is the
caption  "GenoMax,"  above  three  pictures of computer screens, one for each of
"BLAST  Results  View," "Molecule View," and "Array Analysis View." Beneath that
is  the  phrase  "Enterprise Bioinformatics System for High-Throughput Research"
in  a  less  bold  style.  On  the right side is the caption "Vector NTI Suite,"
above   three  pictures  of  computer  screens  for  each  of  "Molecule  View,"
"AlignX(TM)"  and  "ContigExpress.(TM)"  Beneath  that  is  the  phrase "Desktop
Software  for  Integrated  Sequence Analysis and Data Management" in a less bold
style.]

<PAGE>

                              PROSPECTUS SUMMARY

     You  should  read  the  following  summary  together with the more detailed
information  regarding  our  company  and  our  common  stock being sold in this
offering  and  our  consolidated  financial  statements  and  the  notes  to our
consolidated  financial statements appearing elsewhere in this prospectus before
making  an  investment  decision.  You  should  also  consider  the  information
discussed in "Risk Factors."


OUR BUSINESS

     We  are  a  leading  global  provider  of bioinformatic software solutions.
Bioinformatics  involves  the  application  of  information  technology  to  the
analysis  of  genomic,  proteomic  and  other biomolecular data. Genomics is the
study  of an organism's genes, and proteomics is the study of proteins and their
role  in  particular diseases. Our bioinformatic software solutions are designed
to   enable  researchers  to  more  efficiently  organize,  share,  analyze  and
interpret these data that form the genetic blueprint of all organisms.

     We  believe that our position as a leading global provider of bioinformatic
software  is  based  upon the number of our customers, our revenues and the size
of  our  organization.  Since  introducing  our  Vector  NTI  Suite  of software
applications  for  desktop  computers in 1993, we have sold our products to over
1,300  organizations worldwide, including over 500 biotechnology, pharmaceutical
and  agricultural  biotechnology companies, and over 800 academic and government
research institutions. Our customers include:


       o Merck & Company,
       o Genzyme Corporation,
       o Procter & Gamble,
       o Johnson & Johnson,
       o Bristol-Myers Squibb,
       o Pfizer,
       o AstraZeneca,
       o Diversa Corporation,
       o Novartis Agribusiness Biotechnology Research,
       o the Whitehead Institute for Biomedical Research,
       o Massachusetts Institute of Technology,
       o University of Tokyo, and
       o the National Institutes of Health.

     Our  principal  software  products  are  our  Vector  NTI Suite for desktop
computers  and our more powerful and expensive GenoMax enterprise platform for a
network  of  computers  linked together for sharing data and computation. Driven
primarily  by  increased  sales  of  Vector  NTI  Suite  and the introduction of
GenoMax  in  late  1998, our products and complementary services generated $10.0
million  in  revenues  in  1999, representing a four-year compound annual growth
rate of 105%, and a 143% increase over 1998.

     Building  on  our  existing  market  penetration,  we  intend  to  grow our
business   through   increased  software  sales  and  add  new  revenue  through
professional   services,  content  channeling  and  distribution  alliances  and
e-commerce  offerings.  In  August  2000,  we entered into a long-term strategic
relationship  with Amersham Pharmacia Biotech, a subsidiary of Nycomed Amersham,
to  jointly  develop  and  market  an  expanded version of GenoMax to provide an
enterprise-wide  data  analysis  system  for  pharmaceutical  and  biotechnology
companies,  for  integrating  and  analyzing  data from genomics, proteomics and
drug screening production laboratories.

     As  of  September  27,  2000, we employed 205 people, including a sales and
marketing  team  of  54,  a  research  and product development team of 95 and an
implementation and support staff of 25.


                                       3
<PAGE>

     As  of  June  30, 2000, we had an accumulated deficit of $8.2 million and a
net loss of $6.1 million for the six months ended June 30, 2000.

OUR MARKET OPPORTUNITY

     Around  the  world,  researchers  in industry, academia, and government are
producing  vast  quantities of biomolecular data. In June 2000, the Human Genome
Project  and  Celera  Genomics  jointly  announced  that  they had assembled the
world's  first  working  draft  of  the entire human genetic code, consisting of
approximately  3.12 billion nucleotide bases, the chemical subunits that make up
DNA.

     A  central  problem  now  facing researchers is how to organize, integrate,
analyze,  visualize and interpret these complex and rapidly growing data sets to
achieve breakthroughs in:

     o disease diagnosis, treatment and prevention,

     o agricultural production,

     o environmental management, and

     o industrial processes.

Bioinformatic  software  provides tools for researchers to address this problem.
We  believe  that  the  current  and  future  markets for bioinformatic software
products  include all of the industries participating in the genomic revolution,
including:

     o pharmaceutical and biotechnology companies;

     o academic and government research institutions;

     o agricultural, environmental and industrial biotechnology companies; and

     o emerging clinical genomics companies.

     An  August  2000  independent  industry  report  by  Front  Line  Strategic
Management   Consulting   estimates   the   world-wide   bioinformatics  market,
consisting  of sales by providers of analytical software, enterprise systems and
data,  at  approximately  $468  million  in  2000, growing to approximately $2.0
billion  in  2005  and  approximately $5.4 billion in 2010. We believe that this
growth  is  being  driven  by  the  rapid  increase  in biomolecular data and by
organizations   increasingly   turning  to  external  vendors  of  bioinformatic
software solutions so that they can focus on their core research competencies.

OUR SOLUTION

     To  meet  the  challenges and market opportunities presented by the genomic
revolution,  we  develop and deliver to our customers a portfolio of proprietary
bioinformatic   software  products  and  complementary  services.  Our  software
products  are flexible, scalable and are designed to integrate with one another.
Our  software  allows  researchers  to  incorporate,  directly,  or  through the
Internet,  customer  and  third  party  analytical algorithms and data sets. Our
current and announced product portfolio includes:

   o Vector   NTI   Suite,   a   comprehensive  desktop  sequence  analysis  and
     visualization  tool  for  the  laboratory  scientist engaged in genomic and
     protein sequence research.

   o Vector   Enterprise,   an   enhancement   to  the  Vector  NTI  Suite  that
     incorporates  a  common  relational  database,  allowing  multiple users to
     share  data  and  results  in  a  secure environment. Vector Enterprise was
     commercially released on September 29, 2000.


                                       4
<PAGE>

   o GenoMax,  a  large-scale  modular, enterprise-wide data mining and analysis
     application  designed  for  a  coordinated  effort  by  a  diverse  team of
     scientists  within  or  across  commercial, academic or government research
     institutions.  As of September 27, 2000, we have made 20 GenoMax enterprise
     sales.

OUR ADVANTAGES

     We  believe that our competitive advantages will allow us to continue to be
a global leader in bioinformatic software solutions:

     o Superior products and a broad product portfolio;

     o Superior bioinformatic engineering staff;

     o Large existing customer franchise;

     o Vector NTI Suite's market  penetration,  which creates  opportunities for
       new products and business lines; and

     o Superior sales and marketing capabilities.


OUR STRATEGY

     Our  goal  is  to  become  the  leading  provider of bioinformatic software
solutions  and  establish  our  products  as  the  effective  industry standard.
Elements of our strategy to achieve these goals include:

     o Expand our customer franchise through sales of Vector NTI Suite;

     o Build on Vector NTI Suite's market  penetration  to establish  GenoMax as
       the leading enterprise platform;

     o Leverage our customer base for new business lines, including professional
       services,  content  channeling and distribution  alliances and e-commerce
       opportunities;

     o Enhance and expand our technology;

     o Establish strategic relationships to maximize our revenues; and

     o Engage in acquisitions and strategic investments.


OUR OFFICES

     InforMax,  Inc.  was  incorporated  in  Delaware in May 1990. Our principal
office  is  located  at  6010  Executive  Blvd., 10th Floor, Rockville, Maryland
20852.   Our   telephone   number   is   (301)   984-2206.   Our   website   is
www.informaxinc.com.  The  information  found on our website is not part of this
prospectus.


                                       5
<PAGE>

                                 THE OFFERING

<TABLE>
<S>                                                            <C>
Common stock offered by us .................................   5,000,000 shares
Common stock to be outstanding after this offering .........   18,657,720 shares
Use of proceeds ............................................   We will use the net
                                                               proceeds of this offering for
                                                               acquisitions, joint ventures
                                                               and collaborative
                                                               arrangements; research and
                                                               development; increased
                                                               sales and marketing efforts;
                                                               and working capital and
                                                               other general corporate
                                                               purposes.
Nasdaq National Market symbol ..............................   "INMX"
</TABLE>

     The  above  information  is based on our shares outstanding as of September
27, 2000 and excludes:

   o 13,584,645   shares   issuable   upon  exercise  of  common  stock  options
     outstanding,  including 5,054,542 options issued under our equity incentive
     compensation  plan,  at  a  weighted  average  exercise price of $1.402 per
     share  (including  643,340  options  granted  on  September  26, 2000 at an
     exercise price of $15.00 per share); and

     o outstanding warrants to purchase 40,080 shares of our common stock.

     Unless  otherwise  indicated,  the  information in this prospectus reflects
the following corporate actions, each effected on September 11, 2000:

     o a 1.67 for 1 split of our common stock;

     o the  reduction  of our common  stock's  par value from $0.01 per share to
       $0.001 per share;

     o the conversion of all outstanding  shares of our non-voting  common stock
       into common stock; and

     o an  increase in our  authorized  capital  stock to 100 million  shares of
       common stock and 20 million shares of preferred stock.

     Unless otherwise indicated, the information in this prospectus assumes:

     o the filing of our amended and restated  certificate of incorporation,  to
       be effected  immediately  prior to the closing of this  offering,  making
       such  changes as are  described  elsewhere  in this  prospectus,  and the
       amendment of our bylaws;

     o the automatic conversion of all outstanding shares of Series A and Series
       B redeemable  convertible  preferred stock into common stock  immediately
       prior to the closing of this offering; and

     o no exercise by the  underwriters  of their option to purchase  additional
       shares of stock in this offering to cover over-allotments, if any.


                                       6
<PAGE>

                  SUMMARY CONSOLIDATED FINANCIAL INFORMATION

     The  following table sets forth a summary of our consolidated financial and
certain  operating  data for the periods presented. The information in the table
should  be  read together with our consolidated financial statements and related
notes  and  with  "Selected  Financial  Data"  and  "Management's Discussion and
Analysis  of  Financial Condition and Results of Operations," included elsewhere
in this prospectus.

<TABLE>
<CAPTION>
                                                                 YEAR ENDED DECEMBER 31,
                                               -----------------------------------------------------------
                                                  1995      1996       1997         1998          1999
                                               ---------- -------- ------------ ------------ -------------
                                                          (IN THOUSANDS EXCEPT PER SHARE DATA)
<S>                                            <C>        <C>      <C>          <C>          <C>
STATEMENTS OF OPERATIONS DATA:
Revenues:
  Software license and customer support          $  166    $  382    $  1,335     $  2,732     $   7,277
  Professional services ......................      403       636         867        1,394         2,737
                                                 ------    ------    --------     --------     ---------
   Total revenues ............................      569     1,018       2,202        4,126        10,014
Gross profit .................................      405       690       1,448        2,855         7,997
Operating expenses:
  Selling, general and administrative (1)           195       507       1,075        2,476         7,000
  Research and development (2) ...............      165       161         365        1,162         2,597
  Stock based compensation ...................       22        --         211           18           138
  Depreciation and amortization ..............       --         3          18           94           273
                                                 ------    ------    --------     --------     ---------
   Total operating expenses ..................      382       671       1,669        3,750        10,008
Income (loss) from operations ................       23        19        (221)        (895)       (2,011)
Net income (loss) ............................   $   22    $    4    $   (134)    $   (567)    $  (1,315)
Net income (loss) applicable to common
  shares .....................................   $   22    $    4    $   (134)    $   (567)    $  (1,491)
Basic net income (loss) applicable per
  common share (3) ...........................   $ 0.01    $   --   $   (0.04)   $   (0.16)    $   (0.38)
Diluted net income (loss) applicable per
  common share (3) ...........................   $ 0.01    $   --   $   (0.04)   $   (0.16)    $   (0.38)

<CAPTION>
                                                    SIX MONTHS ENDED
                                                        JUNE 30,
                                               --------------------------
                                                   1999          2000
                                               ------------ -------------
                                                      (UNAUDITED)
                                                (IN THOUSANDS EXCEPT PER
                                                       SHARE DATA)
<S>                                            <C>          <C>
STATEMENTS OF OPERATIONS DATA:
Revenues:
  Software license and customer support          $  3,322     $   4,855
  Professional services ......................      1,159         1,655
                                                 --------     ---------
   Total revenues ............................      4,481         6,510
Gross profit .................................      3,604         5,397
Operating expenses:
  Selling, general and administrative (1)           2,397         7,565
  Research and development (2) ...............      1,129         2,471
  Stock based compensation ...................         27           975
  Depreciation and amortization ..............         89           343
                                                 --------     ---------
   Total operating expenses ..................      3,642        11,354
Income (loss) from operations ................        (38)       (5,957)
Net income (loss) ............................   $    (82)    $  (6,069)
Net income (loss) applicable to common
  shares .....................................   $    (82)    $  (6,237)
Basic net income (loss) applicable per
  common share (3) ...........................  $   (0.02)    $   (1.18)
Diluted net income (loss) applicable per
  common share (3) ...........................  $   (0.02)    $   (1.18)
</TABLE>

-----------
(1) Selling,   general   and   administrative   expenses  excludes  stock  based
    compensation   of  $21,916,  $-0-,  $76,189,  $-0-,  $111,019,  $9,643,  and
    $845,741  for  the years ended December 31, 1995, 1996, 1997, 1998, and 1999
    and  the  six months ended June 30, 1999 and 2000 (unaudited), respectively.


(2) Research  and  development  expenses  excludes  stock  based compensation of
    $-0-,  $-0-,  $134,506,  $17,782,  $27,166,  $16,748,  and  $128,874 for the
    years  ended  December  31,  1995,  1996,  1997,  1998, and 1999 and the six
    months ended June 30, 1999 and 2000 (unaudited), respectively.

(3) As  restated  for  the  unaudited  six month period ended June 30, 2000, see
    Note 6 to the consolidated financial statements.

     Following is certain supplemental information for the period presented:

<TABLE>
<CAPTION>
                                                                               SIX MONTHS ENDED
                                          YEAR ENDED DECEMBER 31,                  JUNE 30,
                              ----------------------------------------------- -------------------
                               1995     1996      1997      1998      1999       1999      2000
                              ------ --------- --------- --------- ---------- --------- ---------
                                                                                  (UNAUDITED)
                                (IN THOUSANDS, EXCEPT NUMBER OF VECTOR NTI SUITE
                                LICENSES BOOKED AND NUMBER OF GENOMAX SALES BOOKED)
<S>                           <C>    <C>       <C>       <C>       <C>        <C>       <C>
Revenue Bookings ............  $569   $1,033    $2,561    $5,571    $10,007    $4,224    $8,994
No. of Vector NTI Suite
  Licenses Booked
  (cumulative from 1993).....   331      727     1,399     3,083      6,271     4,094     9,271
No. of GenoMax Sales
  Booked (cumulative
  from 1998) ................    --       --        --         2          8         5        16
</TABLE>

     Revenue bookings represent all contracted sales of products and services.


                                       7
<PAGE>

     The  balance  sheet  data  below  sets  forth a summary of our consolidated
balance sheet at June 30, 2000:

     o on an actual basis;

     o on a pro  forma  basis  to  give  effect  to the  issuance  of  Series  B
       redeemable convertible preferred stock after June 30, 2000, the automatic
       conversion  of  all  outstanding  shares  of our  redeemable  convertible
       preferred  stock into common  stock  immediately  prior to the closing of
       this  offering,  and the  conversion  of all  outstanding  shares  of our
       non-voting  common stock into shares of voting  common stock  effected on
       September 11, 2000; and

     o on a pro forma as adjusted basis to give effect to the issuance of Series
       B  redeemable  convertible  preferred  stock  after  June 30,  2000,  the
       automatic   conversion  of  all  outstanding  shares  of  our  redeemable
       convertible  preferred stock into common stock  immediately  prior to the
       closing of this offering, the conversion of all outstanding shares of our
       non-voting  common stock into shares of voting  common stock  effected on
       September 11, 2000,  and our receipt of the net proceeds from the sale of
       5,000,000  shares of common stock in this offering at the initial  public
       offering  price  of  $16.00  per  share,  after  deducting   underwriting
       discounts and commissions and our estimated offering expenses.

<TABLE>
<CAPTION>
                                                                   AS OF JUNE 30, 2000
                                                        -----------------------------------------
                                                                       (UNAUDITED)
                                                                                     PRO FORMA AS
                                                           ACTUAL      PRO FORMA       ADJUSTED
                                                        -----------   -----------   -------------
                                                                     (IN THOUSANDS)
<S>                                                     <C>           <C>           <C>
BALANCE SHEET DATA:
Cash and cash equivalents ...........................    $  2,091       $12,091        $85,291
Working capital (deficit) ...........................      (1,283)        8,717         81,917
Total assets ........................................      10,109        20,109         93,309
Total debt ..........................................       3,556         3,556          3,556
Redeemable convertible preferred stock ..............       4,263            --             --
Common stock and additional paid-in capital .........       6,269        20,532         93,732
Stockholders' equity (deficit) ......................      (3,449)       10,814         84,014
</TABLE>

     See  our  consolidated financial statements and notes included elsewhere in
this  prospectus for a description of the computation of the net loss per common
share  and  the  number  of  shares  used  in  the per share calculations in the
statement of operations data above.


                                       8
<PAGE>

                                 RISK FACTORS

     You  should carefully consider the following risks before you decide to buy
our  common  stock.  Our business, financial condition and operating results may
suffer  if  any  of  the events described in the following risk factors actually
occur.  If  any of the events we have identified occur, the trading price of our
common  stock  could decline, and you may lose all or part of the money you paid
to buy our common stock in this offering.

                         RISKS RELATED TO OUR BUSINESS

WE  MUST  KEEP  PACE  WITH  RAPID  TECHNOLOGICAL  ADVANCES  AND DEVELOPMENTS NOW
OCCURRING  IN  BIOINFORMATIC  SOFTWARE.  IF WE ARE UNABLE TO DO SO, OUR PRODUCTS
AND  SERVICES  WILL  BE  LESS  ATTRACTIVE  TO  CUSTOMERS  AND  OUR  REVENUES AND
COMPETITIVE POSITION WILL SUFFER.

     The  market  for  our  products  and  services  is  in  the  midst of rapid
technological  change. In order for us to maintain a competitive position in our
industry  and  develop  and market products that are attractive to customers, we
must:

     o continue  to  enhance  and expand the functions of our existing products;
and

     o develop and introduce new software  products and  complementary  services
       that meet evolving  customer needs and  preferences  and  incorporate new
       technologies.

Our  products  and  services  may  not  be  able to keep pace with technological
change.  We  may  not  be able to identify in a timely manner important evolving
industry  standards  and  may invest considerable resources in technologies that
rapidly  become  obsolete.  Our  products  or  product  versions may also become
obsolete   due   to  our  competitors'  introduction  of  products  or  services
containing  advanced  technology  and  functions.  If  we  do not keep pace with
technological  change,  our  products will not be as attractive to our customers
and  our  competitive  position  and  sales  of  our products would be seriously
harmed.


WE  MUST  ADD  NEW  CUSTOMERS  AND  RETAIN  AND  EXPAND  UPON  EXISTING CUSTOMER
RELATIONSHIPS  IN  ORDER  TO  GENERATE  REVENUES  TO  SUPPORT  THE GROWTH OF OUR
BUSINESS.

     In  order  to  generate  additional  revenues  sufficient  to  support  our
continued  growth,  we  must  add new customers and retain, and expand upon, our
existing  customer  relationships.  These  efforts depend significantly upon our
successful  development  of  new  products,  product  versions and services that
respond  to the evolving needs of the genomic research community, as well as the
success   of  our  sales  and  marketing  efforts.  In  addition,  much  of  our
expectation  for  future growth of revenues is based upon increased sales of our
GenoMax  product and the establishment of our GenoMax brand. We expect to derive
a  significant  portion  of  our  future  professional  services  revenue from a
relationship  with  the  National Center for Biotechnology Information (NCBI) at
the  National  Institutes  of  Health  and  that relationship, which is based on
subcontractor arrangements, could be terminated in the future.


THE  CONTINUED  ENHANCEMENT  AND  DEVELOPMENT  OF OUR BIOINFORMATIC PRODUCTS AND
SERVICES  DEPEND  UPON  THE  RETENTION AND EXPANSION OF OUR RESEARCH AND PRODUCT
DEVELOPMENT GROUP.

     The  number  of  technical  personnel  with  experience  in  the  field  of
bioinformatics  is  limited  and competition for qualified employees is intense.
Our  software  was  developed  by an internal team that has had little turnover,
but  that  may  not  be  the  case  in  the  future. We may not be successful in
retaining  our technical employees or recruiting and training additional skilled
personnel.  The  loss  of  a significant number of employees in our research and
product  development  group, occurring at one instance or over a period of time,
could  seriously  harm our product development and enhancement efforts. We could
also  incur  significant  costs  associated  with  any  resulting  litigation or
disputes to protect our proprietary information.


                                       9
<PAGE>

PART  OF OUR BUSINESS STRATEGY IS TO DEVELOP STRATEGIC RELATIONSHIPS WITH LARGER
ORGANIZATIONS  AND  PROVIDERS  OF COMPLEMENTARY PRODUCTS AND SERVICES. IF WE ARE
NOT SUCCESSFUL IN DOING SO OUR ABILITY TO COMPETE COULD BE HARMED.

     A   component   of   our   business   strategy   is  to  develop  strategic
relationships,  including  co-marketing  arrangements,  content  channeling  and
distribution   alliances,  e-commerce  offerings  and  Internet-hosted  delivery
partnerships.  We  believe  that through such relationships we can add revenues,
improve  our  competitive  position and increase market awareness and acceptance
of  our  products.  To  date, we have entered into only a few of these strategic
relationships  with  providers of complementary products and services. If we are
unable  to  successfully  develop  these  and other similar relationships, or if
these  relationships  do  not  yield  the  results we anticipate, our ability to
compete  and  to  generate  future  revenues  could  be  materially  harmed.  In
addition,  most of our strategic relationships, other than our relationship with
Amersham,  including  our co-marketing relationships with Oracle, Compaq and Sun
Microsystems,  are  based  on oral arrangements that are not enforceable and can
be terminated by either party at any time.

     In  August  2000,  we  entered into a long-term strategic relationship with
Amersham  Pharmacia Biotech to jointly develop and market an expanded version of
GenoMax  for  pharmaceutical and biotech companies for integrating and analyzing
data  from  genomics, proteomics and drug screening production laboratories. The
agreement  with  Amersham  can  be  terminated  prior  to the end of the term by
mutual  agreement  of  the  parties  or  by one party upon a breach by the other
party.  In addition, if we do not use commercially reasonable efforts to develop
the  data  analysis  system,  Amersham  can  terminate  the  agreement.  If  the
agreement  is  terminated  for any reason prior to the end of the term or if the
relationship  otherwise  does  not result in the successful marketing of GenoMax
to  new  customer  groups,  we  may  be  unable to recoup all of the substantial
investment  we  will  be  making  in  this  collaboration  and  there would be a
material adverse impact on our anticipated future revenues.

WE  HAVE  INCURRED  OPERATING  LOSSES  IN  THE  PAST RESULTING IN AN ACCUMULATED
DEFICIT. WE MAY NOT ACHIEVE OR MAINTAIN PROFITABILITY IN THE FUTURE.

     We  have  incurred operating losses in most periods since our inception. We
incurred  net  losses  of approximately $0.6 million for the year ended December
31,  1998  and  approximately $1.3 million for the year ended December 31, 1999.
We  incurred  a  net loss of approximately $6.1 million for the six months ended
June  30,  2000.  As  of  June  30,  2000,  we  had  an  accumulated  deficit of
approximately  $8.2  million.  We expect to continue to incur net losses for the
foreseeable  future.  We  expect  to  invest  substantial  financial  and  other
resources to:

     o develop and introduce new products, product versions and services;

     o expand our  research  and  product  development  and sales and  marketing
       groups; and

     o consider appropriate acquisitions and strategic relationships.

     As  a  result,  we expect that our expenses will increase significantly. We
cannot  assure  you  that  we  will  be  able  to generate sufficient additional
revenues   to   achieve   profitability.   Even   if  we  are  able  to  achieve
profitability,  we  may  not  be able to sustain profitability on a quarterly or
annual  basis.  Failure to achieve consistent profitability may limit our growth
potential and the value of our common stock.

REVENUE  RECOGNITION  RULES  APPLICABLE  TO  SOFTWARE  MAY REQUIRE THAT WE DEFER
RECOGNIZING  REVENUES  UNDER  CERTAIN LICENSES UNTIL QUARTERS AFTER LICENSES ARE
EXECUTED  OR  FEES  ARE  RECEIVED.  THIS  CAN  CAUSE  OUR  QUARTERLY  RESULTS TO
FLUCTUATE SUBSTANTIALLY.

     We  may  not  be  able  to  recognize  revenue associated with a particular
software  license in the same quarter in which we enter into the agreement or in
which  we  collect licensing fees. Under some of our licenses we must deliver to
a  customer  an  enhanced product version or additional module, and therefore we
must  defer  recognizing  any  payment previously received until delivery of all
contract


                                       10
<PAGE>

elements  is  made.  For example, in several of our GenoMax sales, our contracts
with  customers  stipulate future delivery of a gene expression analysis module.
In  accordance  with  generally accepted accounting principles, we have deferred
recognition  of revenue on these contracts until delivery of the gene expression
analysis  module.  This  module,  included  in  GenoMax  3.0,  was  delivered on
September  15,  2000. If we are not able to release future modules as scheduled,
we  will  be  required  to  defer  the  recognition  of  a significant amount of
revenues  to  quarters  after those in which we collect licensing fees. Expenses
associated  with software licenses, unlike revenues, are not typically deferred.
The  manner  in  which  we  recognize  revenue,  in  accordance with the revenue
recognition  rules  applicable  to  software under generally accepted accounting
principles,   may   cause   our   quarterly   operating   results  to  fluctuate
substantially.

WE  EXPECT  OUR  RESULTS OF OPERATIONS TO VARY FROM QUARTER TO QUARTER IN FUTURE
PERIODS  AS  A RESULT OF THE TIMING AND SEASONALITY OF OUR SOFTWARE SALES. THESE
FLUCTUATIONS  MAKE  IT  DIFFICULT  TO  EVALUATE  OUR  BUSINESS  AND  COULD CAUSE
INSTABILITY IN OUR STOCK PRICE.

     We  anticipate  that  our  operating  results will fluctuate on a quarterly
basis  as  a  result  of  a  number of factors, many of which are outside of our
control.  Factors  that may cause our quarterly results to fluctuate include the
following:

     o the number and timing of orders for our GenoMax enterprise product;

     o the  seasonal  fluctuations  of  software  procurement,  particularly for
bioinformatics software;

     o the timing of,  commencement,  delay,  cancellation  or completion of our
       software licensing agreements,  strategic  relationships and professional
       service activities;

     o the timing of license,  royalty  and other  payments  received  under our
       agreements;

     o the  introduction  or cancellation of products and services by us and our
       competitors; and

     o the timing of expenses  associated  with increased  product  development,
       expanded  sales and marketing  efforts,  and  acquisitions  and strategic
       investments.

     In  particular,  as  a  result  of the academic calendar, European business
practices  and  commercial  information  technology  procurement  practices,  we
generally  experience a reduction in sales in the third quarter of each calendar
year   which  typically  results  in  a  corresponding  reduction  in  operating
revenues.

     Due  to  the  factors  described  above  and  other risks discussed in this
prospectus,  you  should  not  rely  upon quarterly comparisons of our financial
results.  These  comparisons  are  not  necessarily  meaningful  nor  are they a
reliable  indicator  of  our  future performance. As a result of fluctuations in
our  quarterly  results,  the market price of our common stock may be subject to
significant fluctuation and volatility.

OUR  PRODUCTS  AND  SERVICES,  PARTICULARLY  OUR  ENTERPRISE SOFTWARE SOLUTIONS,
REQUIRE  A  LENGTHY  SALES  CYCLE.  THIS SALES CYCLE OFTEN REQUIRES US TO EXPEND
CONSIDERABLE  RESOURCES. IF WE DEVOTE SIGNIFICANT RESOURCES TO SALES THAT DO NOT
MATERIALIZE,  OUR REVENUES AND ABILITY TO ACHIEVE PROFITABILITY WOULD BE HARMED.

     The  sales cycle for our products and services, particularly our enterprise
software  solutions  on  which  much  of  our expectations for future growth are
based,  is a lengthy and involved process. Our sales cycle is typically long for
a number of reasons, including:

   o the  decision  to  license  and  deploy  enterprise-wide  software,  by its
     nature,  is  an  organization-wide procurement decision, often requiring an
     evaluation  by a significant number of constituencies in various functional
     and  geographic  areas, each often having specific and possibly conflicting
     requirements; and

   o the  significant  resources  that  are  committed  to  an evaluation of our
     software  solutions  by  a  potential  customer  organization require us to
     expend  substantial  time,  effort and money educating them about the value
     and comparative advantages of our products.


                                       11
<PAGE>

In  addition, our agreements with customers and strategic partners often contain
terms  that  are  unique  to  that  customer  or  partner  and require extensive
negotiation.  As  a  result,  we  may  expend  substantial  funds  and effort to
negotiate  agreements  for  these  products,  but  may  ultimately  be unable to
consummate a sale of our products and services.


THE  LOSS  OF  THE  SERVICES OF, OR THE DEVELOPMENT OF SUBSTANTIAL EXTERNAL TIME
COMMITMENTS  BY,  OUR  SENIOR  MANAGEMENT  COULD  HAVE  A NEGATIVE EFFECT ON OUR
GROWTH.

     The  continued  growth  of  our  business is substantially dependent on the
performance  of  our senior management and key employees, especially those named
in  the  "Management"  section  of  this  prospectus.  We  carry key person life
insurance  on  only Dr. Titomirov, our Chief Executive Officer, and Dr. Babenko,
our  Chief  Technology  Officer. In addition, we have employment agreements with
only  Dr.  Babenko,  Mr.  Lehnen, our Chief Financial Officer, and Mr. Sullivan,
our  Senior  Vice  President of Marketing and Sales. The loss of the services of
any  member of our senior management or key personnel may significantly delay or
prevent  the  implementation  of our business strategy and could have a material
adverse effect on the growth of our business.

     Dr.  Titomirov  is  also  the  chairman and a significant stockholder of an
unrelated   company   named   RealTimeHealth.com,   Inc.  RealTimeHealth.com  is
currently  a  development  stage  company  that  intends  to  allow  health care
consumers  to  establish  individual  baseline genetic profiles and then monitor
them  for  a pattern variance over time through the Internet. RealTimeHealth.com
intends  to  hire  and  is  currently  seeking  a  chief  executive officer. Dr.
Titomirov    currently    anticipates   that   his   duties   as   chairman   of
RealTimeHealth.com  will be limited to setting its strategic direction and being
involved  in  fundamental  decisions  and  activities  of the board of directors
generally.  In  August  2000,  we  received  a  commitment  letter regarding the
continued  services of Dr. Titomirov. Although Dr. Titomirov's commitment letter
states  that  he  currently  intends  to  devote  a majority of his professional
working  time  to  his  duties  as  our  Chief Executive Officer, there could be
periods  where  his  activities with RealTimeHealth.com substantially reduce the
time devoted to our operations.


WE  MAY  INCUR  SIGNIFICANT COSTS IN PROTECTING OUR INTELLECTUAL PROPERTY RIGHTS
OR RESPONDING TO CLAIMS OF INFRINGEMENT FROM OTHERS.

     We  currently  rely  upon a combination of trademark, patent, copyright and
trade  secret laws, employee and third party non-disclosure agreements and other
contracts  to  protect  our  proprietary  rights.  Nevertheless,  our efforts to
protect  our  intellectual  property  may  be inadequate and we may be unable to
prevent  others  from  offering  products  and services substantially similar to
ours.   We  also  need  to  secure  and  maintain  adequate  protection  of  our
intellectual  property  outside  of  the  United  States,  because our sales are
global.  The laws of some foreign countries do not protect proprietary rights to
the  same  extent  as the laws of the United States, and many companies engaging
in   international   business  have  encountered  considerable  difficulties  in
safeguarding their proprietary rights in foreign jurisdictions.

     Moreover,  third  parties  may claim that our current or future products or
services  infringe  upon  their  intellectual  property.  Litigation  over these
issues  could  be  a significant distraction and we may incur significant costs,
including  several  damages.  In the event that it is determined that one of our
products  infringe  upon  another's  proprietary  rights,  we may be required to
obtain  a  license  in  order to continue selling our products. That license may
not be available to us on favorable terms, or at all.


OUR  SOFTWARE  FACILITATES  RESEARCH  COLLABORATION  AND  THEREFORE  SECURITY IS
IMPORTANT  TO  OUR  CUSTOMERS.  WE  COULD  BE EXPOSED TO LIABILITY AND A LOSS IN
CUSTOMER CONFIDENCE IF OUR PRODUCTS FAIL TO PROVIDE THAT SECURITY.

     Our  software  facilitates  collaboration among researchers and the sharing
of  research  results. If there is a breach or failure of the security functions
in  our  software,  researchers'  proprietary  work  product  and  data  may  be
compromised  and  our customers would lose confidence in our software. We may be
exposed  to  considerable  liability from defects or breaches of security in our
products.


                                       12
<PAGE>

IF  WE  CANNOT EFFECTIVELY MANAGE OUR GROWTH, AND SPECIFICALLY THE TRANSITION OF
OUR  BUSINESS  RELATED  TO  AN  EMPHASIS ON THE SALE OF ENTERPRISE PRODUCTS, OUR
FUTURE PROSPECTS WOULD BE HARMED.

     In  recent years, we have experienced significant growth in the size of our
customer  base and the scope of our products and services. We also have expanded
and  intend  to  continue  to  expand  our  research  and  product  development,
marketing  and  sales,  and  professional  services organizations. These factors
have  placed, and will continue to place, a significant strain on our management
systems  and  resources.  As  a result of this offering, we will become a public
company,  which  will  place  additional strain on our administrative, financial
and  operational  systems.  Our  current  accounting  information  system may be
inadequate  to  support  our growth. Accordingly, we are presently transitioning
to  a  new  accounting  information  system.  Our  ability  to manage our growth
effectively  will  depend  upon the ability of our officers and key employees to
continue  to implement and improve our operational, administrative and financial
control  systems  and  to  expand, train and manage our workforce, and implement
necessary   changes   to  our  information  systems,  including  our  accounting
information system.

     Historically,  we  have  focused  on the development and sale of our Vector
NTI  Suite  of  desktop  products.  We  are currently seeking to increase market
penetration  and  brand  recognition of our GenoMax enterprise software platform
and,  accordingly are devoting an increasing portion of our resources to GenoMax
related  marketing  and  sales  and  professional  services  efforts. Failure to
successfully  manage  that transition effectively would materially and adversely
affect  nearly  every  aspect  of our business and cause our financial condition
and results of operations to suffer.

WE  SIGNIFICANTLY  DEPEND  UPON HOLDERS OF H-1B NON-IMMIGRANT VISAS TO STAFF OUR
RESEARCH  AND  PRODUCT DEVELOPMENT TEAM. OUR PRODUCT DEVELOPMENT AND ENHANCEMENT
EFFORTS  COULD BE HARMED IF WE ARE NOT ABLE TO ADEQUATELY STAFF OUR TEAM BECAUSE
OF THE LIMITATIONS OF U.S. IMMIGRATION LAWS.

     We  recruit professionals for our research and product development group on
an  international basis and, therefore, must comply with the immigration laws of
the  United  States.  Most  of  our  research  and  product development team are
citizens  of  other countries, with most of those working in the U.S. under H-1B
temporary  visas.  Under  the American Competitiveness and Workforce Improvement
Act  of  1988,  there is a statutory limit of 115,000 new H-1B visas that may be
issued  in fiscal year 2000 with such limit decreasing to 107,500 in 2001 and to
65,000  in  fiscal  year 2002 and thereafter. In any year in which this limit is
reached,  we may be unable to obtain a sufficient number of H-1B visas to employ
those  persons  we  would  like  to  add to our research and product development
group.  If  we  are  unable to obtain H1-B visas for our employees in sufficient
quantities  or  in  a  timely  manner,  our  product development and enhancement
efforts  could  be  hampered.  As a result, we may be unable to deliver products
that satisfy customer preferences and keep pace with technological change.

WE  INTEND  TO  USE  A  PORTION  OF  THE  PROCEEDS  OF THIS OFFERING TO CONSIDER
ACQUISITIONS  OR  STRATEGIC  INVESTMENTS.  WE HAVE LIMITED EXPERIENCE WITH THESE
ACTIVITIES  AND  THE COSTS AND DISTRACTIONS FROM THOSE ACTIVITIES COULD HARM OUR
FUTURE GROWTH.

     We  intend  to  use  a portion of the proceeds of this offering to consider
acquiring  businesses,  technologies or products that we believe are a strategic
fit  with  our  business  and strategy, although we only have limited experience
with  these  activities. If appropriate opportunities become available, we could
also  issue additional equity securities that would dilute current stockholders'
ownership,  or  incur  substantial debt to finance such transactions. Methods of
financing  any  acquisitions or strategic investments could result in a negative
impact  on  our  financial  condition.  We may have difficulties integrating the
businesses,  products,  technologies or personnel involved in any acquisition or
strategic   investment.  Our  integration  efforts  may  result  in  significant
expenditures  of  operating,  financial  and  management  resources  that  could
materially  and  adversely  affect our business. Acquisitions involve many other
risks,  including  potential  loss of key employees or customers, the assumption
of  significant  liabilities,  and  the amortization of the intangible assets of
acquired  companies.  As  a result of these and other risks, any acquisitions or
strategic  investments  may  ultimately  have a negative impact on our business,
results of operation and financial condition.


                                       13
<PAGE>

DEFECTS  OR  MALFUNCTIONS  IN  OUR  SOFTWARE PRODUCTS, OR IN THE PRODUCTS OF OUR
TECHNOLOGY  PARTNERS, COULD HURT OUR REPUTATION AMONG CUSTOMERS AND EXPOSE US TO
LIABILITY.

     Our  business  and  the  level  of customer acceptance of our bioinformatic
software  products  are  dependent  upon  the continuous, effective and reliable
operation  of  our  computer  software and related tools and functions. Software
defects  could  occur  in our current or future products. To the extent that our
software  malfunctions  and  our  customers' use of our products is interrupted,
our  reputation  and  business could suffer. We may also be subject to liability
for  the  defects and malfunctions of third party technology partners and others
with whom our products and services interoperate.

WE  MAY  REQUIRE  ADDITIONAL  FUNDING  TO EXECUTE OUR BUSINESS STRATEGY. IF THAT
FUNDING  IS NOT AVAILABLE, OR NOT AVAILABLE ON TERMS ACCEPTABLE TO US, WE MAY BE
REQUIRED TO CURTAIL CERTAIN MARKETING AND PRODUCT DEVELOPMENT EFFORTS.

     We  expect  that  the  proceeds  from  this  offering,  our  cash flow from
operations  and  our  existing  capital resources will be sufficient to fund our
operations  for  the  next  24  months  but  it is possible that our growth will
require  us  to  seek  additional  financing  during this period. We may seek to
satisfy   any   additional  capital  needs  through  public  or  private  equity
offerings,  debt  financings  and  other  means. If we raise capital through the
issuance  of  additional  equity  securities, your ownership will be diluted. We
may  not  be  able  to obtain additional financing when we need capital on terms
favorable  to  us,  if  at  all.  If  we cannot obtain such financing, we may be
required  to  curtail our marketing and sales activities and product development
efforts.

                         RISKS RELATED TO OUR INDUSTRY

THE  BIOINFORMATIC  PRODUCTS  AND  SERVICES  MARKET IS INTENSELY COMPETITIVE AND
EVOLVING  AND  WE MAY NOT ACHIEVE OR MAINTAIN MARKET LEADERSHIP FOR A VARIETY OF
REASONS.

     We face, or expect to face, intense competition from:

     o third party commercial software vendors;

     o bioinformatics developers;

     o internal  bioinformatics   departments  of  some  of  our  customers  and
       potential customers;

     o organizations engaging in the provision of Internet-hosted, bioinformatic
       software; and

     o companies facilitating  Internet-based e-commerce between participants in
       our industry.

     We  believe  that  we  compete most often with LION biosciences, NetGenics,
Compugen,  Genomica, DNA Star, Rosetta Inpharmatics, DoubleTwist and GCG, a unit
of  Pharmacopeia  recently  acquired  from  Oxford  Molecular. Others, including
large,  well-established software vendors, could readily enter this market. Many
of  our  competitors  have longer operating histories, stronger name recognition
and  significantly  greater financial, technical and marketing resources than we
do.  As  a  result  of  these  advantages, our competitors may be better able to
adopt  more  aggressive  pricing  policies  and  better positioned to respond to
changes in customer preference or technology.

     To  remain  competitive,  we  believe  that  we must continue to expand and
enhance  the  functionality  of  our bioinformatic software products and respond
timely  and  effectively  to  evolving  industry  standards or technology. In an
intensely  competitive,  technology  driven  business  like  ours,  there  is no
certainty  that  market  leadership  can  be  obtained  or  maintained  for  any
sustainable period.

NUMEROUS  CUSTOMERS  AND  POTENTIAL CUSTOMERS FOR OUR BIOINFORMATIC SOFTWARE MAY
ELECT  TO  INTERNALLY  DEVELOP  OR  CONTINUE TO DEVELOP THEIR OWN SOFTWARE WHICH
COULD HURT OUR SALES EFFORTS.

     Our  customers  and potential customers, including providers of genomic and
proteomic  data,  may  elect  to internally develop or continue to develop their
own  bioinformatic  software.  Potential  customers  for  our  products  may  be
unwilling  to  abandon their prior internal efforts to look to an outside, third
party  source to provide their bioinformatic software solutions. As a result our
efforts to add new customers could be hampered.


                                       14
<PAGE>

IF  GROWTH  IN  THE  USE OF GENOMIC DATA DOES NOT OCCUR AS WE EXPECT, THE TARGET
MARKETS FOR OUR PRODUCTS AND SERVICES MAY NOT BE AS LARGE AS EXPECTED.

     The  application  of  genomic  information  to  pharmaceutical discoveries,
agricultural  production,  environmental  management and industrial processes is
an  evolving  and  unproven  practice.  Few  products  have  been  developed and
commercialized  resulting from recent genomic discoveries. If researchers do not
use  genomic information in their discovery and development efforts at the level
we  project,  the  target  markets  for  our  products  and  services  will  not
materialize and our prospects would be materially harmed.

OUR  SALE  OF  BIOINFORMATIC  PRODUCTS  AND  SERVICES  COULD SUFFER IF THERE ARE
REDUCTIONS  IN RESEARCH AND DEVELOPMENT EXPENDITURES OF OUR CUSTOMERS AND PUBLIC
FUNDING RELATED TO GENOMIC RESEARCH.

     Sales  of  our products and services could suffer as a result of reductions
in  customer research and development expenditures and public funding related to
genomic  research.  Our continued services to the NCBI and sales of our products
to  other  government  and academic institutions could be negatively affected by
reductions in such public funding.

THE  PRODUCTS  AND  THE  ACTIVITIES  OF  OUR  CUSTOMERS,  INCLUDING THOSE IN THE
PHARMACEUTICAL   AND  BIOTECHNOLOGY  INDUSTRIES,  MAY  BE  SUBJECT  TO  CHANGING
REGULATION  THAT  COULD  ADVERSELY  AFFECT  GENOMIC  RESEARCH  AND REDUCE MARKET
DEMAND FOR OUR PRODUCTS.

     Because  our customers' products potentially touch on areas involving human
health,  they are affected by current or future government regulation, including
regulation  by  the  U.S.  Food  and  Drug Administration. Recently, the Clinton
administration  proposed  legislation regarding oversight of the sale of medical
products  over  the  Internet  and announced its intention to implement a set of
regulatory  initiatives  governing genetically engineered agricultural products.
In  addition,  numerous laws covering genetic testing of humans, the privacy and
security  of  human  genetic  information,  and  the storage and transmission of
individually  identifiable  health  care  information  have  been  introduced or
passed  at the state and federal levels. Our sales may indirectly be affected by
changes  in  government  regulation  covering our customers in these industries,
including  regulation  relating  to  drug development, genomic research, genetic
testing,  healthcare  reform and the sale of products and transfer of healthcare
data over the Internet.

     We  cannot  assure  you  that  customers  and  potential  customers for our
bioinformatic  software  products and related services will not curtail or defer
technology  investments  in  response  to  the  proposal or institution of these
governmental  efforts.  Moreover,  any  exposure by us to liability or increased
government  scrutiny  resulting  from regulatory or legal changes would distract
the  efforts  of  our  organization and require us to spend significant time and
resources  in connection with any resulting litigation or regulatory compliance.

OUR  BUSINESS  MAY  BE MATERIALLY AND ADVERSELY AFFECTED AS A RESULT OF ETHICAL,
LEGAL AND SOCIAL CONCERNS SURROUNDING THE USE OF GENOMIC INFORMATION.

     A  number  of  ethical, legal and social concerns, including issues related
to  privacy,  confidentiality  and  fairness,  have  arisen  as  a result of the
increased  availability  of genomic information. Government and private entities
are currently exploring issues, including:

     o ownership and control of genomic information;

     o definition of normal conditions, disabilities and disorders; and

     o determination  of access rights to resulting  expensive  technologies and
       responsibility for payment for treatment based on these technologies.

As  a  result  of  these  and  numerous  other ethical, legal and social issues,
government   authorities   may  limit,  or  increasingly  regulate  biomolecular
research   and   the   use  of  products  resulting  from  such  research.  Such
restrictions  could reduce the number of markets and potential customers for our
products and could materially and adversely affect our business.


                                       15
<PAGE>

CONSOLIDATION  WITHIN  THE  PHARMACEUTICAL AND BIOTECHNOLOGY INDUSTRIES MAY LEAD
TO  FEWER  CUSTOMERS FOR OUR PRODUCTS AND SERVICES. CONSOLIDATION COULD INCREASE
COMPETITION AND HARM OUR MARKETING AND SALES EFFORTS.

     A  significant  portion of our customer base consists of pharmaceutical and
biotechnology  companies.  Mergers  between  large  multinational pharmaceutical
companies  have  accelerated in recent years. Continued consolidation within the
pharmaceutical  and  biotechnology  industries may result in fewer customers for
our  products  and  services.  If one of the parties to a consolidation uses the
products  or  services  of  our competitors, we may lose existing customers as a
result of such consolidation.

WE  INTEGRATE THIRD PARTY DATABASES INTO OUR BIOINFORMATIC SOFTWARE PRODUCTS AND
MAY BE EXPOSED TO LIABILITY FOR CONTENT ERRORS IN THOSE DATABASES.

     Available  genomic,  proteomic  and  other  biomolecular  data  is vast and
complex,  and errors in databases containing this information are inevitable. We
integrate  data  housed  on  public  and  private  content  databases  into  our
bioinformatic  software  products.  We  could  be subject to claims of liability
associated  with  damages  resulting from any erroneous third party data that we
integrate  into  our  products or for which we facilitate delivery and analysis,
even if not integrated into our products.

                        RISKS RELATED TO THIS OFFERING

OUR COMMON STOCK MAY HAVE A VOLATILE TRADING PRICE AFTER THIS OFFERING.

     Prior  to  this  offering,  our  common stock has not been sold in a public
market.  You will pay a price that we negotiated with the representatives of the
underwriters  based  on  a number of factors. The price you pay for our stock in
this  offering  may  be  different  from  a  price  established in a competitive
market.  After  this  offering,  an active trading market in our stock might not
develop.  If  an  active  trading  market does develop, it may not continue. The
trading  price  of  our common stock may fluctuate widely as a result of a large
number  of  factors.  The  stock market has experienced extreme price and volume
fluctuations  that have affected the market prices of many companies involved in
the  software  and  biotechnology industries, which have often been unrelated to
the operating performance of these companies.

A  SIGNIFICANT  NUMBER  OF  OUR SHARES ARE ELIGIBLE FOR RESALE AFTER THE DATE OF
THE  OFFERING.  FUTURE  SALES  OF THESE SHARES MAY CAUSE THE MARKET PRICE OF OUR
COMMON STOCK TO FALL AND REDUCE OUR ABILITY TO RAISE CAPITAL.

     If  our existing stockholders sell substantial amounts of our common stock,
including  shares issuable upon the exercise of outstanding options or warrants,
or  if  the  market perceives that such sales may occur, the market price of our
common  stock may fall. After this offering, we will have outstanding 18,657,720
shares  of common stock. This includes the 5,000,000 shares of common stock that
we  are  selling  in  this offering and which may be resold in the public market
immediately.  This also includes approximately 13,657,720 shares of common stock
which  are  not  registered  but  which  are  eligible  for resale in the public
market,  subject  to  compliance  with Rule 144 or Rule 701 under the Securities
Act  of  1933, as amended. While the holders of most of these shares are subject
to  lock-up  agreements with the underwriters in the offering for 180 days after
the  date of the final prospectus for the offering, Bear, Stearns & Co. Inc., in
its  sole  discretion,  may  release any portion or all of these shares from the
lock-up  restrictions.  In  addition,  sales  of  a substantial number of shares
could  occur  at any time after the expiration of the 180-day period. Holders of
8,541,276  shares  of  our  common stock, or warrants exercisable for our common
stock,  are  entitled  to  certain  registration  rights.  If  these holders, by
exercising  their  registration  rights,  cause  a  large number of shares to be
registered  and  sold in the public market, these sales could cause a decline in
the  market  price of our common stock. If we were to include, in a registration
statement  initiated  by  us,  shares  held  by these holders in accordance with
their  registration  rights, the inclusion of such shares may reduce our ability
to raise capital.


                                       16
<PAGE>

OUR  EXECUTIVE  OFFICERS  AND  DIRECTORS  AND  THEIR AFFILIATES WILL OWN A LARGE
PERCENTAGE  OF OUR COMMON STOCK FOLLOWING THE OFFERING AND WILL HAVE THE ABILITY
TO INFLUENCE DECISIONS THAT COULD ADVERSELY AFFECT OUR STOCK PRICE.

     Following   the  completion  of  this  offering,  our  executive  officers,
directors  and  their affiliates will own approximately 60.0% of the outstanding
shares  of  common  stock.  As  a  result,  these  stockholders  will be able to
substantially   influence   all  matters  requiring  stockholder  approval  and,
thereby,  our  management  and  affairs.  Matters  that will require stockholder
approval include:

     o election of directors;

     o approval of certain mergers or consolidations;

     o sale of all or substantially all of our assets; and

     o issuance  of large  amounts  of our  shares in  private  transactions  or
       acquisitions.

     This  concentration  of  ownership  may  delay,  deter or prevent acts that
would  result  in a change of control of our company, which in turn could reduce
the  market  price  of our common stock. This concentration may also prevent new
investors from influencing significant corporate decisions.


INVESTORS  PARTICIPATING IN THIS OFFERING WILL INCUR IMMEDIATE DILUTION OF THEIR
COMMON STOCK BASED ON ITS BOOK VALUE AFTER THE OFFERING.

     The  offering  price  will  be  substantially higher than the pro forma net
tangible  book  value  of  our  common stock as of June 30, 2000. At the initial
public  offering  price  of  $16.00  per  share, the pro forma net tangible book
value  of  the common stock is $4.67 per share. This represents an immediate and
substantial  dilution  per  share  of  $11.33 for investors purchasing shares in
this  offering.  The  dilution  per  share represents the difference between the
amount  per  share  paid  by  the  purchasers  of shares of common stock in this
offering  and  the  pro  forma net tangible book value per share of common stock
immediately  after  the  completion of this offering. In addition, to the extent
outstanding  options  or  warrants are exercised, there will be further dilution
to new investors.

OUR   CHARTER  AND  BYLAWS  AND  DELAWARE  LAW  CONTAIN  PROVISIONS  THAT  COULD
DISCOURAGE A TAKEOVER EVEN IF BENEFICIAL TO STOCKHOLDERS.

     Our  charter  and  our  bylaws,  and  portions  of  Delaware  law,  contain
provisions  that  could  make  it  more  difficult  for  a third party to obtain
control  of  InforMax, even if doing so would be beneficial to stockholders. For
example,  our  amended and restated certificate of incorporation to be effective
immediately  prior  to  the  closing  of this offering provides for a classified
board  of  directors,  allows the board of directors to expand its size and fill
any  vacancies  without  stockholder approval, and allows the board of directors
to  classify  and issue preferred stock without stockholder approval. Our bylaws
restrict  the  ability  of  stockholders  to  call a special meeting and require
advance  notice of stockholder proposals. Delaware law makes it difficult for us
to  be  acquired by a significant stockholder that is not approved in advance by
our board of directors.

WE  WILL  RETAIN BROAD DISCRETION IN THE USE OF THE NET PROCEEDS WE RECEIVE FROM
THIS  OFFERING  AND  MAY  SPEND  A  SUBSTANTIAL  PORTION  IN WAYS WITH WHICH YOU
DISAGREE.

     We  will  retain a significant amount of discretion over the use of our net
proceeds  from  this  offering,  as well as over the timing of our expenditures.
Because  of the number and variability of factors that will determine our use of
the  net  proceeds,  we  may  apply  the  net  proceeds  in  ways with which you
disagree.


                                       17
<PAGE>

               SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

     We  make statements in this prospectus that are forward-looking statements.
These  statements  are subject to risks and uncertainties. These forward-looking
statements  are  generally accompanied by words such as "may," "will," "intend,"
"anticipate,"  "believe,"  "estimate," "expect," "should" or similar expressions
or  the  negative  of the expressions. These statements are only predictions and
actual  events  or  results  may differ materially. Although we believe that the
expectations  reflected  in  the  forward-looking  statements are reasonable, we
cannot   guarantee   future   results,   levels   of  activity,  performance  or
achievements.  You  should  understand that these forward-looking statements are
subject  to  a  number  of assumptions, risks and uncertainties that could cause
our  actual  results to differ materially from those expressed or implied in the
forward-looking  statements.  Important  factors that could cause actual results
to  differ  materially  from  the  estimates  or  projections  we  make  in  our
forward-looking  statements  include those described in "Risk Factors." In light
of  the  risks  we  describe  in  "Risk  Factors," the forward-looking events we
discuss  in  this  prospectus  may  not  occur.  Except  for  duties  imposed by
applicable  law,  we  do  not  intend  to  publicly  update or revise any of the
forward-looking statements in this prospectus.

                               ----------------

     The  marks  InforMax  &  Double  Helix  Design  and  Vector NTI, AlignX and
BioPlot  are registered trademarks of InforMax, Inc. InforMax, InforMax's Double
Helix   Logo   Design,  GenoMax,  ContigExpress,  High-Throughput  Research  and
Software  Solution  for  Bio-Medicine, are each trademarks of InforMax, Inc. and
U.S.  trademark applications for these marks have been filed. Vector Enterprise,
Vector  NTI  Suite,  Dynamic  License Server Research Logic and Research Logic &
Design  are trademarks of InforMax, Inc. All other product, service, and company
names contained in this prospectus are trademarks of other parties.


                                       18
<PAGE>

                                USE OF PROCEEDS

     We  estimate  that  we  will receive net proceeds from this offering of our
common  stock  of approximately $73,200,000, or approximately $84,360,000 if the
underwriters'  over-allotment  option  is  exercised  in  full. This estimate is
based  on the initial public offering price of $16.00 per share, and deducts the
underwriting discounts and commissions and our estimated offering expenses.

     The  principal  purposes  of  this offering are to provide working capital,
create  a  public  market  for our common stock, facilitate our future access to
the  public  capital  markets  and  increase  our  visibility in our markets. We
anticipate  that,  subject  to the availability of opportunities on terms and at
prices  we  deem  acceptable,  we would allocate as much as 80% and as little as
20%  of  the  net  proceeds to expanding our business through the acquisition of
additional  businesses,  products  and  technologies  and  to establishing joint
ventures  or  other  collaborative  arrangements which we believe complement our
current  or  future  business.  We  anticipate that the remaining portion of the
offering  proceeds  would  be  allocated  approximately  one-third  to expanding
research  and  development,  approximately  one-third  to  expanding  sales  and
marketing  and  approximately one-third to working capital and general corporate
purposes.  We  have  no  specific  plans,  agreements  or commitments to use the
proceeds  for  any specific acquisition or collaborative arrangement and, to the
extent  appropriate  opportunities are not available, all proceeds not allocated
to  external expansion would be applied to internal expansion, through expanding
our  research  and  development  and  our  sales  and  marketing efforts, and to
working  capital  and  general  corporate purposes. The amounts that we actually
expend  for  the purposes above will vary significantly depending on a number of
factors,  including  future  revenue  growth,  if any, and the amount of cash we
generate  from  operations.  As a result, we will retain broad discretion in the
allocation  of  the net proceeds of this offering. Until we use the net proceeds
of  this  offering,  we  intend  to invest them in U.S. government securities or
investment-grade, interest-bearing instruments.

     We  expect  that  the  net  proceeds  from  this  offering,  cash flow from
operations  and  our  existing  capital resources will be sufficient to fund our
operations  for  the  next  24  months,  but it is possible that our growth will
require us to seek additional financing during this period.

                                DIVIDEND POLICY

     We  have  never  declared  or  paid  any  dividends on our common stock. We
expect  to  retain  all  earnings,  if  any, generated by our operations for the
development  and  growth of our business. We do not intend to pay cash dividends
on  our common stock for the foreseeable future. However, our board of directors
is  free to change our dividend policy in the future, based upon factors such as
our  results  of  operations,  financial  condition,  cash  flow, cash needs and
future  prospects. If our board of directors were to change our dividend policy,
so  long  as we have any amount outstanding under our credit facilities with PNC
Bank,  National  Association,  we would be required to obtain PNC Bank's written
consent prior to the declaration or payment of such dividends.


                                       19
<PAGE>

                                CAPITALIZATION

     The following table shows our capitalization as of June 30, 2000:

     o on an actual basis;

     o on a pro  forma  basis  to  give  effect  to the  issuance  of  Series  B
       redeemable convertible preferred stock after June 30, 2000, the automatic
       conversion  of all  redeemable  convertible  preferred  stock into common
       stock  immediately  prior  to the  closing  of  this  offering,  and  the
       conversion  of the  outstanding  non-voting  common  stock into shares of
       voting common stock effected on September 11, 2000;

     o on a pro forma basis as adjusted to give effect to the issuance of Series
       B  redeemable  convertible  preferred  stock  after  June 30,  2000,  the
       automatic conversion of all redeemable  convertible  preferred stock into
       common  stock  immediately  prior to the  closing of this  offering,  the
       conversion  of the  outstanding  non-voting  common  stock into shares of
       voting common stock  effected on September  11, 2000,  and our receipt of
       the net  proceeds  from the sale of  5,000,000  shares of common stock in
       this offering at the initial  public  offering price of $16.00 per share,
       after deducting  underwriting discounts and commissions and our estimated
       offering expenses.

<TABLE>
<CAPTION>
                                                                                         AS OF JUNE 30, 2000
                                                                           -----------------------------------------------
                                                                                             (UNAUDITED)
                                                                                                              PRO FORMA
                                                                                ACTUAL        PRO FORMA      AS ADJUSTED
                                                                           --------------- --------------- ---------------
<S>                                                                        <C>             <C>             <C>
Long-term debt ...........................................................  $  1,241,973    $  1,241,973    $  1,241,973
Series A redeemable convertible preferred stock, par value $0.01 --
 2,161,265 shares authorized, issued, and outstanding, actual, and no
 shares authorized, issued or outstanding pro forma and pro forma as
 adjusted ................................................................     4,263,194              --              --
                                                                            ------------    ------------    ------------
Series B redeemable convertible preferred stock, par value $0.01 -- no
 shares authorized, issued and outstanding actual, pro forma and pro
 forma as adjusted (1) ...................................................            --              --              --
                                                                            ------------    ------------    ------------
Stockholders' equity (deficit):
 Preferred stock, par value $0.01, 20,000,000 shares authorized, no
   shares issued or outstanding, actual, pro forma and pro forma as
   adjusted ..............................................................            --              --              --
 Common stock - voting, par value $0.001; 100,000,000 shares
   authorized, 2,254,500 shares issued and outstanding, actual;
   12,983,068 shares issued and outstanding, pro forma; 17,983,068
   shares issued and outstanding, pro forma as adjusted ..................         2,255          12,983          17,983
 Common stock - nonvoting, par value $0.001; 14,931,864 shares
   authorized, 5,531,508 issued and outstanding, actual; no shares
   authorized, issued or outstanding, pro forma and pro forma as
   adjusted ..............................................................         5,531              --              --
Subscription receivable ..................................................    (1,013,436)     (1,013,436)     (1,013,436)
Additional paid-in capital ...............................................     6,260,877      20,518,874      93,713,874
Deferred compensation ....................................................      (461,734)       (461,734)       (461,734)
Accumulated deficit ......................................................    (8,242,199)     (8,242,199)     (8,242,199)
                                                                            ------------    ------------    ------------
    Total stockholders' equity (deficit) .................................    (3,448,706)     10,814,488      84,014,488
                                                                            ------------    ------------    ------------
Total capitalization .....................................................  $  2,056,461    $ 12,056,461    $ 85,256,461
                                                                            ============    ============    ============
</TABLE>

----------
(1) 950,747  shares  of  Series  B convertible preferred stock were issued after
June 30, 2000.

                                       20
<PAGE>

     In  addition  to  the  shares  of common stock to be outstanding after this
offering,  we  may  issue  additional shares of common stock under the following
plans and arrangements:

     o 13,425,125   shares  issuable  upon  exercise  of  outstanding   options,
       including   4,656,122   options   issued   under  our  equity   incentive
       compensation  plan, at a weighted  average  exercise  price of $0.622 per
       share as of June 30, 2000;

     o 1,356,494 shares available for future issuance under our equity incentive
       compensation plan as of June 30, 2000; and

     o 40,080 shares issuable upon exercise of outstanding warrants.

Please  read  the  capitalization table together with our consolidated financial
statements  and  related notes and with the sections of this prospectus entitled
"Selected   Financial   Data"  and  "Management's  Discussion  and  Analysis  of
Financial  Condition  and  Results  of  Operations"  included  elsewhere in this
prospectus.


                                       21
<PAGE>

                                   DILUTION

     Our  pro  forma  net  tangible  book  value  as  of June 30, 2000 was $10.8
million,  or $0.83 per share of common stock. We have calculated this amount by:


     o subtracting our total liabilities from total tangible assets; and

     o then  dividing the  difference by the total pro forma number of shares of
       common stock outstanding,  including the number of shares of common stock
       that will be  issued  upon the  automatic  conversion  of all  redeemable
       convertible   preferred   stock,   including   the  Series  B  redeemable
       convertible  preferred  stock issuance  after June 30, 2000,  immediately
       prior to the completion of this offering.

     After  giving effect to the sale of 5,000,000 shares of our common stock in
this  offering  and deducting the underwriting discounts and commissions and our
estimated  offering  expenses, our adjusted pro forma net tangible book value as
of  June 30, 2000 would have been $84.0 million, or $4.67 per share. This amount
represents  an  immediate  dilution  of  $11.33  per share to new investors. The
following table illustrates this per share dilution:

<TABLE>
<S>                                                                      <C>          <C>
Initial public offering price per share ..............................                 $  16.00
                                                                                       --------
 Pro forma net tangible book value per share before this offering.....    $  0.83
 Increase in pro forma net tangible book value per share
   attributable to new investors .....................................       3.84
                                                                          -------
Pro forma net tangible book value per share after this offering ......                     4.67
                                                                                       --------
Dilution per share to new investors ..................................                 $  11.33
                                                                                       ========
</TABLE>

     The  following table summarizes on a pro forma basis after giving effect to
this  offering,  as  of  June  30,  2000,  the  differences between the existing
stockholders  and  new  investors with respect to the number of shares of common
stock  purchased  from  us,  the  total consideration paid to us and the average
price  per  share  paid  before deducting underwriting discounts and commissions
and our estimated offering expenses:

<TABLE>
<CAPTION>
                                                                                           AVERAGE PRICE
                                           SHARES                      TOTAL                PER COMMON
                                         PURCHASED                 CONSIDERATION               SHARE
                                  ------------------------   --------------------------   --------------
                                     NUMBER       PERCENT        AMOUNT        PERCENT
                                  ------------   ---------   -------------   ----------
<S>                               <C>            <C>         <C>             <C>          <C>
Existing stockholders .........   12,983,068        72.2%    $4,891,717           5.8%       $  0.38
New investors .................    5,000,000        27.8     80,000,000          94.2        $ 16.00
                                  ----------       -----     ----------         -----
 Total ........................   17,983,068       100.0%    84,891,717         100.0%
                                  ==========       =====     ==========         =====

</TABLE>

     If  the  underwriters  exercise  their over-allotment option in full, there
will  be  an increase in pro forma net tangible book value of $5.08 per share to
existing  stockholders  and an immediate dilution in pro forma net tangible book
value  of $10.92 to new investors. Our existing stockholders would own 69.3% and
our  new  public  investors would own 30.7% of the total number of shares of our
common stock outstanding after this offering.

     The  foregoing  discussion  and  tables are based upon the number of shares
actually  issued  and  outstanding on June 30, 2000 plus the number of shares of
Series  B  convertible  preferred stock issued after June 30, 2000 and assume no
exercise  of  options  or  warrants  outstanding as of June 30, 2000. As of that
date,   there   were   13,425,125  shares  issuable  upon  exercise  of  options
outstanding  at a weighted average exercise price of $0.622 per share as of June
30, 2000 and 40,080 shares issuable upon exercise of outstanding warrants.

     To  the  extent that these or any other outstanding options or warrants are
exercised, there will be further dilution to new investors.


                                       22
<PAGE>

                     SELECTED CONSOLIDATED FINANCIAL DATA

     You  should read our selected consolidated financial data together with our
consolidated   financial   statements   and   their   related   notes  and  with
"Management's  Discussion  and  Analysis  of  Financial Condition and Results of
Operations,"  which  we  have  included  elsewhere  in  this prospectus. We have
derived  the statement of operations data for the years ended December 31, 1997,
1998  and  1999 and the balance sheet data as of December 31, 1998 and 1999 from
our  audited  consolidated  financial  statements  included  elsewhere  in  this
prospectus.  These  consolidated  financial  statements  have  been  audited  by
Deloitte  & Touche LLP. We have derived the statement of operations data for the
years  ended  December  31,  1995  and  1996  from  our  unaudited  consolidated
financial  statements  that  are  not  included  in this prospectus. The balance
sheet  data  as  of  December  31,  1995 and 1996 are derived from our unaudited
consolidated  financial statements that are not included in this prospectus. The
balance  sheet  data  as  of  December  31,  1997  are  derived from our audited
consolidated financial statements that are not included in this prospectus.

     We  have  derived the statement of operations data for the six months ended
June  30,  1999 and 2000 and the balance sheet data as of June 30, 2000 from our
unaudited  consolidated  financial  statements,  which  have  been  prepared  on
substantially  the  same  basis as the audited consolidated financial statements
and,  in  the opinion of management, include all adjustments, consisting only of
normal  recurring  adjustments, necessary for a fair presentation of the results
of operations for these periods.

     The  historical  results  presented below are not necessarily indicative of
future results.

<TABLE>
<CAPTION>
                                                                                                        SIX MONTHS ENDED
                                                              YEAR ENDED DECEMBER 31,                       JUNE 30,
                                               ----------------------------------------------------- -----------------------
                                                1995      1996       1997       1998         1999       1999        2000
                                               ------ ----------- --------- ------------ ----------- --------- -------------
                                                                                                           (UNAUDITED)
                                                       (IN THOUSANDS EXCEPT PER SHARE DATA)
<S>                                            <C>    <C>         <C>       <C>          <C>         <C>       <C>
STATEMENT OF OPERATIONS DATA:
Revenues:
 Software license and customer support .......  $166    $ 382      $1,335      $2,732     $  7,277    $3,322     $ 4,855
 Professional services .......................   403      636         867      1,394         2,737     1,159       1,655
                                                ----    -----      ------      ------     --------    ------     -------
   Total revenues ............................   569    1,018       2,202      4,126        10,014     4,481       6,510

Cost of revenues:
 Software license and customer support .......     8       19          38        190           405       146         233
 Professional services (1) ...................   156      309         716      1,081         1,612       731         880
                                                ----    -----      ------      ------     --------    ------     -------
   Total cost of revenues ....................   164      328         754      1,271         2,017       877       1,113

Gross profit .................................   405      690       1,448      2,855         7,997     3,604       5,397

Operating expenses:
 Selling, general and administrative (2) .....   195      507       1,075      2,476         7,000     2,397       7,565
 Research and development (3) ................   165      161         365      1,162         2,597     1,129       2,471
 Stock based compensation ....................    22       --         211         18           138        27         975
 Depreciation and amortization ...............    --        3          18         94           273        89         343
                                                ----    -----      ------      ------     --------    ------     -------
   Total operating expenses ..................   382      671       1,669      3,750        10,008     3,642      11,354

Income (loss) from operations ................    23       19        (221)      (895)       (2,011)      (38)     (5,957)

Other income (expense):
 Investment earnings .........................    --       --          --         --            66         2          16
 Interest expense ............................    --         (4)      (19)       (60)          (86)      (33)       (120)
 Other .......................................    --       --         (12)          (3)        (10)       --            (8)
                                                ----    -------    ------      --------   --------    ------     ----------
   Total other income (expense) ..............    --         (4)      (31)       (63)          (30)      (31)       (112)
Income (loss) before income taxes ............    23       15        (252)      (958)       (2,041)      (69)     (6,069)
Income tax expense (benefit) .................     1       11        (118)      (391)         (726)       13          --
                                                ----    -------    ------      -------    --------    ------     ---------
Net income (loss) ............................  $ 22    $   4      $ (134)     $(567)     $ (1,315)   $  (82)    $(6,069)
</TABLE>

                                       23
<PAGE>

<TABLE>
<CAPTION>
                                                                                                          SIX MONTHS ENDED
                                                             YEAR ENDED DECEMBER 31,                          JUNE 30,
                                              ------------------------------------------------------ --------------------------
                                                 1995     1996     1997       1998         1999          1999         2000
                                              ---------- ------ ---------- ---------- -------------- ----------- --------------
                                                                                                            (UNAUDITED)
                                                       (IN THOUSANDS EXCEPT PER SHARE DATA)
<S>                                           <C>        <C>    <C>        <C>        <C>            <C>         <C>
Accretion of transaction costs on
 redeemable convertible preferred stock .....       --     --         --         --             (8)         --             (8)

Accrued dividend on redeemable
 convertible preferred stock ................       --     --         --         --         (168)           --         (160)

Net income (loss) applicable to common
 shares .....................................   $   22    $ 4    $  (134)   $  (567)     $(1,491)      $   (82)     $(6,237)
                                                ======    ===    =======    =======      =========     =======      =========
Basic net income (loss) applicable per
 common share (4) ...........................   $ 0.01    $--    $ (0.04)   $ (0.16)     $ (0.38)      $ (0.02)     $ (1.18)
                                                ======    ===    =======    =======      =========     =======      =========
Diluted net income (loss) applicable per
 common share (4) ...........................   $ 0.01    $--    $ (0.04)   $ (0.16)     $ (0.38)      $ (0.02)     $ (1.18)
                                                ======    ===    =======    =======      =========     =======      =========
</TABLE>

----------
(1) Cost  of  revenues - professional services includes stock based compensation
    of  $-0-,  $-0-,  $105,539,  $-0-, $-0-, $-0- and $5,497 for the years ended
    December  31,  1995,  1996, 1997, 1998, 1999 and the six month periods ended
    June 30, 1999 and 2000, respectively.

(2) Selling,   general   and   administrative   expense   excludes  stock  based
    compensation   of   $21,916,  $-0-,  $76,189,  $-0-,  $111,019,  $9,643  and
    $845,741  for  the years ended December 31, 1995, 1996, 1997, 1998, 1999 and
    the six month periods ended June 30, 1999 and 2000, respectively.

(3) Research  and development expense excludes stock based compensation of $-0-,
    $-0-,  $134,506,  $17,782, $27,166, $16,748 and $128,874 for the years ended
    December  31,  1995,  1996, 1997, 1998, 1999 and the six month periods ended
    June 30, 1999 and 2000, respectively.

(4) As  restated  for  the  unaudited  six month period ended June 30, 2000, see
    Note 6 to the consolidated financial statements.

<TABLE>
<CAPTION>
                                                                    AS OF DECEMBER 31,                     AS OF JUNE 30,
                                                   ----------------------------------------------------   ---------------
                                                    1995     1996      1997        1998         1999            2000
                                                   ------   ------   --------   ---------   -----------   ---------------
                                                                                                            (UNAUDITED)
                                                                      (IN THOUSANDS)
<S>                                                <C>      <C>      <C>        <C>         <C>           <C>
BALANCE SHEET DATA:
Cash and cash equivalents ......................    $ 16     $ 35     $  382     $  296      $  1,399        $  2,091
Working capital (deficit) ......................      72       62        371       (419)        1,040          (1,283)
Total assets ...................................     114      250      1,114      2,883         7,265          10,109
Capital lease obligations, less current
 portion .......................................      --        8         55        182            92              49
Equipment loan facility, less current
 portion .......................................      --       --         --         --           623           1,242
Total liabilities ..............................      38      174        974      3,288         4,887           9,295
Redeemable convertible preferred stock .........      --       --         --         --         4,095           4,263
Common stock and additional paid-in
 capital .......................................     233      233        550        588           975           6,269
Stockholders' equity (deficit) .................      76       76        139       (405)       (1,717)         (3,449)
</TABLE>

     See  our  consolidated financial statements and notes included elsewhere in
this  prospectus  for a description of the computation of the net loss per share
and  the  number  of  shares  used in the per share calculations in statement of
operations data above.


                                       24
<PAGE>

                    MANAGEMENT'S DISCUSSION AND ANALYSIS OF
                 FINANCIAL CONDITION AND RESULTS OF OPERATIONS

     The  following  is a discussion of our consolidated financial condition and
results  of  operations.  You  should  read  this  discussion  together with our
consolidated  financial statements and the related notes, which we have included
elsewhere  in this prospectus. We make some forward-looking statements about our
future  performance. These forward-looking statements include numerous risks and
uncertainties,  such  as  those  described in the "Risk Factors" section of this
prospectus, and accordingly our actual results may differ materially.

OVERVIEW

     We  are  a leading global provider of bioinformatic software solutions. Our
bioinformatic  software  enables  the  analysis  and  interpretation of genomic,
proteomic  and  other  biomolecular  data that form the genetic blueprint of all
living  organisms.  Since  beginning  commercial  operations  in  1993,  we have
dedicated  substantial  resources  to  expand  and  enhance our software product
lines,  increase  our sales and marketing efforts, and enlarge and diversify our
customer base.

     We  believe that our position as a leading global provider of bioinformatic
software  is  based upon the number of our customers, our revenues, and the size
of  our  organization.  In  1993,  we  commercially  released  our first desktop
software  product,  the  current  version of which is marketed as our Vector NTI
Suite  6.0  for  desktop  computers. In September 1998, we commercially released
our  Software  Solution  for  Bio-Medicine  enterprise  computing  platform, the
current  version  of  which was commercially released on September 15, 2000, and
is marketed as GenoMax 3.0.

     To  date,  we  have  sold  over  9,000 licenses for our Vector NTI Suite of
software  applications  for  desktop  computers, with more than 20,000 estimated
users.  We have also made 20 sales of our GenoMax enterprise platform for use by
a  network  of  computers  linked together for sharing data and computation. Our
customer  base  includes  over 1,300 organizations worldwide, including over 500
biotechnology,  pharmaceutical  and  agricultural biotechnology and life science
companies  and  over 800 academic and government research institutions. In 1999,
our  10  largest  customers  accounted  for  less than 37% of our total software
license revenues.

     In  August  2000,  we  entered  into a strategic relationship with Amersham
Pharmacia  Biotech  to jointly develop and market an expanded version of GenoMax
to  provide  an  enterprise-wide  data  analysis  system  for pharmaceutical and
biotechnology  companies,  for  integrating  and  analyzing  data from genomics,
proteomics  and  drug screening production laboratories. In connection with this
relationship,  Amersham  purchased  950,747  shares  of  our  preferred stock in
exchange for $10 million in cash.

     Our  revenue  has  increased substantially in recent years. Revenue for the
year  ended December 31, 1999 represents a four-year compound annual growth rate
of  105%  and  a 143% increase over the prior year. We provide sales, marketing,
implementation  and  support services for our products. Our Vector NTI Suite and
GenoMax  software  products  are  considered off-the-shelf products that require
only routine installation to be fully functional by the end user.

     We  currently  generate  revenues  from software sales and software-related
professional   services.  Software  sales  consist  of  software  license  fees,
maintenance  fees,  and  related  customer  training. Professional services have
historically   consisted   of   software  development  services  provided  under
contracts  to  the  National  Center for Biotechnology Information (NCBI) at the
National  Institutes  of  Health  and  beginning  in  2000  have  also  included
customer-specified   software   installation,   integration   and  customization
services  related  to  our  commercial  software  products.  NCBI  contracts for
professional   services   through   intermediaries   for  whom  we  serve  as  a
subcontractor.  These  agreements  may  be  terminated  on behalf of NCBI at any
time.

     We  expect to generate future revenues from our channeling and distribution
alliances   and   from   e-commerce   offerings.  Channeling  alliances  include
agreements   with   data  content  providers  to  integrate  their  biomolecular
databases  with  our  software  products  and  to  resell subscriptions to these
databases  to  our  customers.  Distribution  alliances  include agreements with
providers  of  specialized  bioinformatic hardware to integrate and resell their
hardware  with  our software products. Under our content channeling and hardware
distribution alliances, we intend to generate transaction fees and


                                       25
<PAGE>

realize  a  portion of the revenues for the products we resell. To date, we have
entered  into  four  agreements to resell third party data content or technology
hardware.  E-commerce  offerings  will include incorporating Internet hyperlinks
into   our  Vector  NTI  Suite  and  entering  into  related  partnerships  with
laboratory  reagent vendors to generate transaction fees on sales we facilitate.
For  additional  information regarding our channeling and distribution alliances
and  our  e-commerce  offerings  please  refer  to  "Business -- Our Product and
Service Lines."

     We   recognize  software  license  revenues  based  on  the  provisions  of
Statement  of  Position  ("SOP")  No.  97-2,  Software  Revenue  Recognition, as
amended  by  SOP No. 98-4 and SOP No. 98-9. Software license fees are recognized
as  revenue  upon the customer's execution of a non-cancelable license agreement
and  delivery  of  the  software,  provided  that  the  license fee is fixed and
determinable,  collectibility  is probable, and no customization of the software
is  required.  In  connection  with  our  software  licenses, we also enter into
maintenance   contracts   that   provide  for  technical  support  and  periodic
unspecified upgrades.

     During  1997  and 1998, we recognized maintenance revenue together with the
initial  licensing  fee  upon delivery of the software when all of the following
were met:

     o the maintenance fee was included with the initial licensing fee,

     o the maintenance revenue to be recognized was for one year or less,

     o the estimated cost of providing  maintenance  during the  arrangement was
       insignificant, and

     o any unspecified upgrades were expected to be minimal.

In  circumstances  where  these  criteria  were  not  met and the fair value for
undelivered  elements  of  a  multiple  element  contract were not determinable,
revenue  on  the  contract  was  entirely  deferred  until either fair value was
determinable  or  when  all  elements  were  delivered.  If  we  were  unable to
establish  vendor  specific  objective evidence of fair value on the undelivered
elements  and the only undelivered element was maintenance, then all revenue was
recognized ratably over the maintenance period.

     Due  to  the introduction of new modules, product enhancements, and product
versions,  we  increased  our  maintenance  support  staff and, as a result, the
estimated  cost of providing maintenance services to our customers was no longer
deemed  insignificant.  Therefore,  beginning in January 1999, revenues from all
software  maintenance contracts were unbundled from software licenses based upon
vendor  specific  objective  evidence  of fair value and recognized ratably over
the  maintenance  period.  Vendor  specific  objective  evidence for maintenance
contracts  is  determined  by  the list price established by management with the
relevant  authority or by the renewal rate specified in the contract. We use the
residual  method to recognize revenue on delivered elements when vendor specific
objective  evidence  of  fair  value  has  been  determined  for all undelivered
elements.  Discounts,  if  any,  are  applied  to  the delivered elements if the
residual  method  is  used.  Amounts  received  in  advance  of  the delivery of
products or performance of services are classified as deferred revenues

     Training  is  provided on a daily fee basis and we recognize revenue as the
services are provided.

     Beginning   in   2000,   we   have   provided  customer-specified  software
installation,  integration  and customization services related to our commercial
software  products  on  a  time and materials basis and recognize revenue as the
services  are  provided.  During  1997,  1998 and 1999 our professional services
revenue  was  derived  from  contracts  related to software development services
provided    to    NCBI   under   time   and   materials   subcontracts   and   a
cost-plus-fixed-fee    subcontract.    During   1999   the   cost-plus-fixed-fee
subcontract  was  converted upon its renewal to a time and material contract. We
recognize  revenue  under the time and material subcontracts as the services are
provided   based  upon  contractual  rates.  We  recognized  revenue  under  the
cost-plus-fixed-fee  subcontract as recoverable costs were incurred, including a
proportionate amount of the fixed fee.


                                       26
<PAGE>
     Our  quarterly  operating  results  have  historically  fluctuated  and  we
anticipate  such  results  to  continue to fluctuate significantly. Factors that
may   cause   our   quarterly  results  to  fluctuate  include  the  timing  of,
commencement, delay, cancellation or completion of our:

     o software licensing agreements;

     o product delivery schedules;

     o strategic relationships; and

     o professional  service  activities,  including  installation  and software
       modification.

Our  results  of  operations  may  also  fluctuate as a result of the number and
timing  of  orders  for  our  GenoMax  enterprise  product,  which  can  have  a
significant effect on revenues for a particular quarter.

     The  manner in which we recognize revenue, in accordance with the generally
accepted  accounting  principles, may also cause our quarterly operating results
to  fluctuate  substantially.  In  accordance  with  these principles, we may be
required  to  defer  all  or  a portion of the revenue from some of our software
licenses  sold  in  a particular quarter to a later quarter. Expenses associated
with  software  licenses  are  not  typically  so  deferred. For our maintenance
contracts  and  professional  services, we typically recognize revenues over the
term of the contract.

     As  a  result  of  the  academic  calendar, European business practices and
commercial   information   technology   procurement   practices,   we  generally
experience  a  reduction  in  sales  in  the third quarter of each calendar year
which  typically results in a corresponding reduction in operating revenues. Due
to  the  factors  described  above and other risks discussed in this prospectus,
you  should  not  rely  upon  quarterly  comparisons of our financial results as
these  comparisons  are  not  necessarily  meaningful  nor  are  they a reliable
indicator of our future performance.

     For  the  period  from  July  1,  2000  through August 21, 2000, we granted
161,990  qualified  options  to employees and 33,400 nonqualified options to one
nonemployee.  These  options  were  issued  with  an exercise price of $6.37 per
share.  The deemed fair market value of the underlying common stock was $6.37 at
each  grant  date  prior  to  July  10,  2000  and  $15.00  at  each  grant date
thereafter.   Deferred   compensation   related  to  the  qualified  options  is
$1,289,883,  which will be amortized to expense over a four year vesting period.
Compensation  related  to  the nonemployee options, which vest over a three year
period,  is  $373,037.  On  September  26,  2000,  we  granted 643,340 qualified
options to employees with an exercise price of $15.00 per share.

RESULTS OF OPERATIONS

     The  following  table sets forth our audited consolidated operating results
for  the  years  ended  December  31, 1997, 1998 and 1999, and for the unaudited
six-month  periods  ended  June  30, 1999 and 2000, as a percentage of our total
revenue for the respective periods.

<TABLE>
<CAPTION>
                                                                                     SIX MONTHS ENDED
                                                      YEAR ENDED DECEMBER 31,            JUNE 30,
                                                   ------------------------------   -------------------
                                                     1997       1998       1999       1999       2000
                                                   --------   --------   --------   --------   --------
                                                                                        (UNAUDITED)
<S>                                                <C>        <C>        <C>        <C>        <C>
Revenues
 Software license and customer support .........       61%        66%        73%        74%        75%
 Professional services .........................       39         34         27         26         25
                                                       --         --         --         --         --
   Total revenues ..............................      100        100        100        100        100

Cost of revenues:
 Software license and customer support .........        2          5          4          3          4
 Professional services .........................       32         26         16         17         14
                                                      ---        ---        ---        ---        ---
   Total cost of revenues ......................       34         31         20         20         18

Gross profit ...................................       66         69         80         80         82

Operating expenses
 Selling, general and administrative ...........       49         60         70         53        116
 Research and development ......................       16         29         26         25         38
 Stock based compensation ......................       10         --          1          1         15
 Depreciation and amortization .................        1          2          3          2          5
                                                      ---        ---        ---        ---        ---
</TABLE>
                                       27
<PAGE>


<TABLE>
<CAPTION>
                                                                                         SIX MONTHS ENDED
                                                    YEAR ENDED DECEMBER 31,                  JUNE 30,
                                            ---------------------------------------   -----------------------
                                                1997          1998          1999         1999         2000
                                            -----------   -----------   -----------   ----------   ----------
<S>                                         <C>           <C>           <C>           <C>          <C>
Total operating expenses ................        76            91           100           81          174
Loss from operations ....................       (10)          (22)          (20)          (1)         (92)
Other income (expense)
 Investment earnings ....................       --             --             1           --          --
 Interest expense .......................        (1)           (1)           (1)          (1)          (2)
 Other ..................................       --             --             0           --          --
                                                ----          -----         -----        ----         -----
   Total other income (expense) .........        (1)           (1)            0           (1)          (2)
Loss before income taxes ................       (11)          (23)          (20)          (2)         (94)
Income tax benefit ......................        (5)           (9)           (7)          --           --
                                                -----         ------        ------       ----         -----
Net loss ................................        (6)%         (14)%         (13)%         (2)%        (94)%
                                                ====          =====         =====        ====         =====
</TABLE>

Six Months Ended June 30, 2000 and 1999

     Revenues.  For  the  six months ended June 30, 2000, revenues increased 45%
to  $6.5  million  from $4.5 million in the corresponding period of 1999. Due to
revenue  deferrals  required  under  SOP  97-2, a significant portion of revenue
from  new  software  license  agreements entered into in the first six months of
2000  will  be  recognized in subsequent periods. Deferred revenue increased 99%
to  $3.6  million  at June 30, 2000 from $1.8 million at December 31, 1999. This
increase  is  primarily  attributable  to  the  deferral of software maintenance
revenues,  both  for our Vector NTI Suite and our GenoMax enterprise system. The
increase  is  also  attributable to deferrals related to contracts requiring the
delivery  of  the GenoMax gene expression analysis module which was delivered to
customers  on September 15, 2000. Subsequent to the delivery of the GenoMax gene
expression  analysis  module,  revenues  will  be  recognized  if  there  are no
additional  undelivered  elements  related to such contracts for which we do not
have vendor specific evidence of fair value.

     Software  sales  revenue  increased  46% to $4.9 million for the six months
ended  June 30, 2000 from $3.3 million in the corresponding period of 1999. This
increase  resulted  primarily  from  increased sales of our Vector NTI Suite and
sales  of  our  GenoMax  enterprise  system,  which was introduced in late 1998.
Increased  Vector NTI Suite sales resulted primarily from expansion of our sales
force.

     Professional  services  revenue  increased  43% to $1.7 million for the six
months  ended  June  30,  2000  from $1.2 million in the corresponding period of
1999.  This  increase  resulted  primarily  from  an  expansion  of our services
provided  to  the  NCBI  and  an  increase in the number of personnel performing
services  under  our  subcontracts.  For  the  six  months  ended June 30, 2000,
services  provided  to the NCBI under subcontracts accounted for $1.5 million or
90% of professional services revenue and 23% of consolidated revenues.

     Cost  of Revenues. For the six months ended June 30, 2000, cost of revenues
increased  27%  to $1.1 million from $0.9 million in the corresponding period of
1999.  Costs  of  software  revenues  consist  primarily  of manufacturing costs
incurred  on an as needed basis that is driven by supply level, cost of shipping
products,  and  the  cost  of  providing training and customer support. Costs of
professional  services  revenues  consist  primarily  of salaries, benefits, and
related expenses of our professional services personnel.

     Costs  of  software  license  and customer support revenue increased 59% to
$0.2  million  for  the  six months ended June 30, 2000 from $0.1 million in the
corresponding  period  of  1999. This increase resulted primarily from increased
sales of our Vector NTI Suite and sales of our GenoMax enterprise system.

     Costs  of  professional services revenues increased 20% to $0.9 million for
the  six  months  ended  June  30,  2000  from $0.7 million in the corresponding
period  of  1999.  This  increase resulted primarily from increased personnel on
the NCBI subcontracts.

     Margins  on  our  software  license  and  customer support and professional
services  revenues  improved  for  the  six-month  period  ended  June  30, 2000
compared to the prior comparable period


                                       28
<PAGE>

primarily  as  a  result  of  the  increasing  size of our customer base and the
reduction  in  the  relative  cost  of producing products and providing services
stemming  from  our spreading production overhead costs across a larger customer
base.

     Selling,  General  and  Administrative  Expenses.  For the six months ended
June  30,  2000,  selling, general and administrative expenses increased 216% to
$7.6  million  from  $2.4  million  in  the  corresponding  period of 1999. This
increase   primarily  reflects  salary  and  benefits  expenses  for  additional
personnel  and  related  expenses  including  increased rent and travel costs to
support  our  business  and  revenue  growth, along with costs associated with a
significant  increased  marketing effort. Overall headcount for the period ended
June  30,  2000  was  173 compared to 79 in the corresponding period of 1999. In
connection  with  this increase in headcount selling, general and administrative
expenses experienced a similar proportionate increase.

     Research  and Development Expenses. For the six months ended June 30, 2000,
research  and  development  expenses  increased  119%  to $2.5 million from $1.1
million  in  the corresponding period of 1999. The increase reflects expense for
an  increase in the headcount of our research and product development team as we
expand  our  product development efforts. Overall headcount for the period ended
June  30,  2000  was  173 compared to 79 in the corresponding period of 1999. In
connection  with  this  increase  in headcount research and development expenses
experienced a similar proportionate increase.

     Stock  Based  Compensation.  For  the six months ended June 30, 2000, stock
based  compensation  expenses increased 3593% to $1.0 million from $0.03 million
in  the corresponding period of 1999. The increase reflects compensation related
to discounted stock option grants and restricted stock awards.

     Income  Taxes. We incurred net losses for each of the six months ended June
30,  2000  and  1999.  At  present,  we  have  an accumulated net operating loss
carryforward  of  $21.4  million,  primarily  as  a  result  of  the exercise of
non-qualified  stock  options.  The  tax provision for the six months ended June
30,  1999  and  2000  was $0.01 million and $0.0 million, respectively, using an
effective  rate  of 18.7% and 0%, respectively. The provision for the six months
ended  June  30,  2000  reflects  a  valuation  allowance  recorded  against the
increase  in  net operating losses and the change in book basis versus tax basis
of deferred revenue and stock based compensation.

     Net  Loss.  We incurred a net loss of $6.1 million for the six months ended
June  30,  2000,  compared  with  a net loss of $0.08 million for the six months
ended June 30, 1999.

Years Ended December 31, 1999 and 1998

     Revenues.  For the year ended December 31, 1999, revenues increased 143% to
$10.0 million from $4.1 million for the year ended December 31, 1998.

     Software  sales revenue increased 166% to $7.3 million from $2.7 million in
the  year  ended  December  31,  1998  due  to increased sales of our Vector NTI
desktop  software  and the introduction of our GenoMax enterprise system in late
1998.

     Professional  services  revenue  increased  96%  to  $2.7 million from $1.4
million  in  the  prior  year.  In  1999,  services  provided  to the NCBI under
subcontracts  accounted  for  100%  of  professional services revenue and 27% of
consolidated revenues.

     Cost  of  Revenues.  For  the year ended December 31, 1999, overall cost of
revenues increased 59% to $2.0 million from $1.3 million in the prior year.

     Costs  of  software  license and customer support revenue increased 113% to
$0.4  million  from  $0.2  million  in  the  prior  year. This increase resulted
primarily  from  increase manufacturing, shipping costs as a result of increased
software license sales and costs of providing training and customer support.

     Costs  of professional services revenues increased 49% to $1.6 million from
$1.1  million  in  the  prior  year.  This  increase resulted primarily from the
increase in personnel on the NCBI subcontracts.

     Selling,  General  and Administrative Expenses. For the year ended December
31,  1999,  selling,  general and administrative expenses increased 183% to $7.0
million  from  $2.5  million  in the year ended December 31, 1998. This increase
primarily  reflects  our  large  investment in sales and marketing personnel and
includes  salary  and  benefits for an increase in headcount, and increased rent
and travel costs to support our revenue growth.

                                       29
<PAGE>

     Research  and  Development  Expenses. For the year ended December 31, 1999,
research  and  development  expenses  increased  123%  to $2.6 million from $1.2
million  in  the  year ended December 31, 1998. This increase reflects increases
in  the  headcount  for  our  research  and  product development team reflecting
expanded product development efforts.

     Stock  Based  Compensation.  For  the  year  ended December 31, 1999, stock
based  compensation  expenses  increased 677% to $0.1 million from $0.02 million
in  the  year  ended  December  31, 1998. The increase reflects discounted stock
option grants and restricted stock awards.

     Income  Taxes.  We incurred net losses for each of the years ended December
31,  1999  and  1998.  At December 31, 1999, we had an accumulated net operating
loss  carryforward of $1.3 million. The tax benefit for the years ended December
31,  1998  and  1999  was  $0.4 million and $0.7 million, respectively, using an
effective  rate  of 40.8% and 35.6%, respectively. The decrease in the effective
tax  rate  is  attributable  to  a  reduction  in  research  and development tax
credits,  a rate differential in the utilization of net operating losses carried
back  to  1997, and compensation expense associated with qualified stock options
in  1999,  which  is  not  deductible  for tax purposes. The increase in the tax
benefit  primarily  reflects the increase in net operating losses and the change
in  book  basis  versus  tax  basis  of  deferred  revenue, which is included in
taxable income at the date of sale but deferred for book purposes.

     Net  Loss.  We  incurred  a  net  loss  of  $1.3 million for the year ended
December  31,  1999  and  a net loss of $0.6 million for the year ended December
31, 1998.

Years Ended December 31, 1998 and 1997

     Revenues.  For  the year ended December 31, 1998, revenues increased 87% to
$4.1 million from $2.2 million in the year ended December 31, 1997.

     Software  sales revenue increased 105% to $2.7 million from $1.3 million in
the prior year due to increased sales of our Vector NTI desktop software.

     Professional  services  revenue  increased  61%  to  $1.4 million from $0.9
million  in  the prior year. In 1998, professional services provided to the NCBI
under  subcontracts  accounted for 100% of professional services revenue and 34%
of consolidated revenues.

     Cost  of  Revenues.  For  the year ended December 31, 1998, overall cost of
revenues increased 69% to $1.3 million from $0.8 million in the prior year.

     Costs  of  software  license and customer support revenue increased 399% to
$0.2  million  from  $0.04  million  in  the  prior year. This increase resulted
primarily  from  increase  manufacturing  and  shipping  costs  as  a  result of
increased software license sales.

     Costs  of professional services revenues increased 51% to $1.1 million from
$0.7  million  in  the  prior  year.  This  increase resulted primarily from the
increase in personnel on the NCBI subcontracts.

     Selling,  General  and Administrative Expenses. For the year ended December
31,  1998,  selling,  general and administrative expenses increased 130% to $2.5
million  from  $1.1  million in the prior year. This increase primarily reflects
increased  salary  and benefits for an increase in headcount, and increased rent
and travel costs to support revenue growth.

     Research  and  Development  Expenses. For the year ended December 31, 1998,
research  and  development  expenses  increased  219%  to $1.2 million from $0.4
million  in  the  year ended December 31, 1997. This increase reflects increases
in  the  headcount  for  our  research  and  product development team reflecting
expanded product development efforts.

     Stock  Based  Compensation.  For  the  year  ended December 31, 1998, stock
based  compensation expenses decreased 92% to $0.02 million from $0.2 million in
the  year  ended  December  31,  1997.  The  decrease  reflects  a  reduction of
non-qualified discounted stock option grants.

     Income  Taxes.  We  incurred net losses for each of the year ended December
31,  1998  and  1997.  At December 31, 1998, we had an accumulated net operating
loss  carryforward of $0.3 million. The tax benefit for the years ended December
31, 1997 and 1998 was $0.1 million and $0.4 million, respectively,


                                       30
<PAGE>

using  an  effective  rate of 46.9% and 40.8%, respectively. The decrease in the
effective  tax  rate  is attributable to a reduction in research and development
tax  credits  in  1998  in  comparison to 1997. The research and development tax
credit  is  the  result  of  qualifying expenditures incurred in relation to the
development of our software products.

     Net  Loss.  We  incurred  a  net  loss  of  $0.6 million for the year ended
December  31,  1998  and  a net loss of $0.1 million for the year ended December
31, 1997.

Quarterly Results of Operations

     The  following  table sets forth unaudited quarterly consolidated financial
data  and  additional  data  for  the five quarters in the period ended June 30,
2000,  and  includes  such  data  as  a  percentage of our total revenue for the
periods  indicated. The unaudited quarterly consolidated financial data has been
prepared   on  a  basis  consistent  with  the  audited  consolidated  financial
statements,  which are included in this prospectus, and include all adjustments,
consisting  only  of normal recurring adjustments, that we consider necessary to
present  fairly  this information when read in conjunction with our consolidated
financial statements and notes thereto in this prospectus.

<TABLE>
<CAPTION>
                                                                 QUARTER ENDED
                                     ----------------------------------------------------------------------
                                           JUNE 30,            SEPTEMBER 30,             DECEMBER 31,
                                             1999                   1999                     1999
                                     -------------------- ------------------------ ------------------------
                                                                  (UNAUDITED)
                                                                 (IN THOUSANDS)
<S>                                  <C>       <C>        <C>           <C>        <C>          <C>
Revenues:
 Software license and customer
  support ..........................  $2,273       79%      $  1,136        59%       $2,820         78%
 Professional services .............     618       21            779        41          799          22
                                      ------       --       --------        --        ------         ---
  Total revenues ...................   2,891      100          1,915       100        3,619         100

Cost of revenues:
 Software license and customer
  support ..........................      76        3             71         4          187           5
 Professional services .............     388       13            422        22          459          13
                                      ------      ---       --------       ---        ------        ----
  Total cost of revenues ...........     464       16            493        26          646          18

Gross profit .......................   2,427       84          1,422        74        2,973          82

Operating expenses:
 Selling, general and
  administrative ...................   1,309       45          1,871        97        2,732          75
 Research and development ..........     644       22            637        34          831          23
 Stock based compensation ..........       9       --             26         1           86           2
 Depreciation and amortization            48        2             78         4          105           3
                                      ------      ---       --------       ---        ------        ----
  Total operating expenses .........   2,010       69          2,612       136        3,754         103

Income (loss) from operations ......     417       15         (1,190)      (62)        (781)        (21)

Other income (expense):
 Investment earnings ...............       1       --             42         2           22          --
 Interest expense ..................     (17)      (1)           (22)       (1)         (32)         (1)
 Other .............................               --             (4)       --           (7)         --
                                      ------      -----     ----------     -----      -------       ------
  Total other income
   (expense) .......................     (16)      (1)            16         1          (17)         (1)

Income (loss) before income
 taxes .............................     401       14         (1,174)      (61)        (798)        (22)

Income tax provision (benefit) .....     146        5           (434)      (23)        (305)         (8)
                                      ------      -----     ----------     -----      -------       ------
Net income (loss) ..................  $  255        9%      $   (740)      (38)%      $(493)        (14)%
                                      ======      =====     ==========     =====      =======       =====
Headcount:
 Number of Personnel
  (Cumulative) .....................      79                     104                    117

<CAPTION>
                                                       QUARTER ENDED
                                     --------------------------------------------------
                                            MARCH 31,                 JUNE 30,
                                               2000                     2000
                                     ------------------------ -------------------------
                                                        (UNAUDITED)
                                                       (IN THOUSANDS)
<S>                                  <C>           <C>        <C>           <C>
Revenues:
 Software license and customer
  support ..........................   $ 2,411         75%      $ 2,443          74%
 Professional services .............       797         25           858          26
                                       -------         --       -------          --
  Total revenues ...................     3,208        100         3,301         100

Cost of revenues:
 Software license and customer
  support ..........................       100          3           132           4
 Professional services .............       425         13           455          14
                                       -------        ---       -------         ---
  Total cost of revenues ...........       525         16           587          18

Gross profit .......................     2,683         84         2,714          82

Operating expenses:
 Selling, general and
  administrative ...................     3,424        107         4,141         125
 Research and development ..........       961         30         1,510          46
 Stock based compensation ..........       556         17           418          13
 Depreciation and amortization             148          5           195           6
                                       -------        ---       -------         ---
  Total operating expenses .........     5,089        159         6,264         190

Income (loss) from operations ......    (2,406)       (75)       (3,550)       (108)

Other income (expense):
 Investment earnings ...............         6         --             9           0
 Interest expense ..................       (45)        (1)          (75)         (2)
 Other .............................        (5)        --            (3)          0
                                       -------        ---       -------         ---
  Total other income
   (expense) .......................       (44)        (1)          (69)         (2)

Income (loss) before income
 taxes .............................    (2,450)       (76)       (3,619)       (110)
Income tax provision (benefit) .....        --         --            --           0
                                       ---------      -----     ---------      ------
Net income (loss) ..................   $(2,450)       (76)%     $(3,619)       (110)%
                                       =========      =====     =========      ======
Headcount:
 Number of Personnel
  (Cumulative) .....................       147                      173

</TABLE>

     Software  license  and  customer  support  revenues reported on a quarterly
basis  from June 30, 1999 through June 30, 2000 increased substantially with the
exception  of  the quarter ended September 30, 1999. This increase resulted from
increased sales of our Vector NTI Suite and GenoMax enterprise


                                       31
<PAGE>

system.  For  the  quarter  ended  September  30,  1999, sales were lower due to
seasonal  fluctuations  of software procurement and the deferral of revenue as a
result  of  the  application  of revenue recognition criteria in accordance with
generally accepted accounting principles.

     Professional  services  revenue reported on a quarterly basis from June 30,
1999  through  June  30,  2000  increased  substantially.  The addition of a new
subcontract  in  the  quarter  ended  September  30,  1999  and modifications to
existing  contracts  for  the  other  reported  periods  increased the number of
personnel  performing  services  under  our subcontracts and therefore increased
the overall professional services revenue.

     Software  license  and customer support costs reported on a quarterly basis
from  June  30, 1999 through June 30, 2000 fluctuated throughout the quarters as
a  result of manufacturing costs incurred on an as needed basis driven by supply
level.

     Professional  services  costs  reported  on a quarterly basis from June 30,
1999  through  June  30,  2000  increased  in  relation  to  the addition of new
contracts  and  modification  of  our  existing contracts. For the quarter ended
March  31,  2000,  there was a decrease in the cost of professional services due
to a decrease in the number of personnel working on the contracts.

     Operating  expenses  reported  on  a  quarterly  basis  from  June 30, 1999
through  June  30, 2000 increased as we experienced substantial growth. Expenses
include   additional   personnel  and  related  salary  and  benefits  expenses,
significant  marketing  efforts  and  other  costs that support our business and
revenue growth such as travel and rent expense.

MARKETS

     Geographically,  North  America,  Europe,  and  Japan represent our largest
markets,  accounting  for  68%,  22%,  and  5%,  respectively,  of sales in 2000
through  June  30,  2000,  and 79%, 17%, and 1%, respectively, of sales in 1999.
All  sales to foreign-based customers are invoiced and paid in U.S. dollars. Our
customer  base  is  comprised of companies in the pharmaceutical, biotechnology,
and  agricultural-life  science  sectors,  as  well  as  academic and government
research institutes.

LIQUIDITY AND CAPITAL RESOURCES

     From  our commencement of commercial operations in 1993 until June 1999, we
funded  our  growth primarily with internally generated cash flow. In June 1999,
we  raised  $4.0  million  in  venture  financing. At June 30, 2000, we had $2.1
million  in  cash and cash equivalents, a net decrease of $2.1 million from June
30,  1999,  an  increase of $0.7 million from December 31, 1999, and an increase
of $1.8 million from December 31, 1998.

     During  the  six  months  ended  June  30,  2000 and 1999 we generated $7.4
million  and  $4.8 million of gross cash from operations before consideration of
cash  outflows, respectively. For the years ended December 31, 1999 and 1998, we
generated  $9.0  million  and  $4.4 million of gross cash from operations before
consideration  of cash outflows, respectively. Gross cash used by operations for
the  six  months  ended June 30, 2000 was $11.0 million compared to $4.5 million
for  the  six  months ended June 30, 1999. Gross cash used by operations for the
year  ended December 31, 1999 was $11.6 million compared to $4.4 million for the
year  ended  December 31, 1998. The net increase in cash used by operations over
these  periods  reflects  the  continued growth of our business, particularly as
related to personnel and related infrastructure expenses.

     Net  cash  provided  by  financing  activities was $5.5 million for the six
months  ended  June  30,  2000  compared  to  net  cash  provided  by  financing
activities  of $4.0 million for the comparable period in 1999. Net cash provided
by  financing  activities  was $5.1 million for the year ended December 31, 1999
and  $0.05  million  for  the  comparable  period  in  1998. On June 22, 1999 we
entered  into  a purchase agreement with FBR Technology Venture Partners, LP for
the  sale  of  2,161,265 shares of our series A redeemable convertible preferred
stock,  $0.01  par  value.  The  shares were sold for an aggregate price of $4.0
million, or $1.85 per share.


                                       32
<PAGE>

     Net  cash  used in investing activities was $1.2 million for the six months
ended  June  30,  2000 compared to net cash used in investing activities of $0.3
million  for  the  comparable  period  in  1999.  Net  cash  used  in  investing
activities  was  $1.4  million  for  the  year ended December 31, 1999 and $0.07
million  for  comparable  period  in 1998. The cash used in investing activities
over those periods were for the purchase of furniture and equipment.

     In  May  1999,  we  entered  into a loan agreement and a security agreement
with  PNC  Bank,  National  Association,  in  connection  with the creation of a
credit  facility  consisting of a secured revolving credit line and an equipment
line  of  credit.  In  February 2000, we entered into a fourth amendment to such
loan  agreement  increasing  the  maximum availability under each of the secured
revolving  credit line and equipment line of credit to $3.0 million, for a total
of  $6.0  million. In connection with this amendment, we entered into an amended
and  restated  revolving  credit note and an amended and restated equipment line
of credit note.

     The  revolving  credit  note  allows  us to borrow, repay and re-borrow the
principal  thereunder  until  February 2, 2001. An amount equal to our qualified
accounts  receivable  is  available  for  borrowing  under  this  note.  Amounts
outstanding  under  the  revolving credit note accrue interest at the prime rate
as  reported in the Wall Street Journal plus one percent per annum with interest
due  and  payable  each month. The principal and any accrued but unpaid interest
are  due and payable on February 2, 2001, or such later date as may be agreed to
by PNC Bank and us.

     The  equipment line of credit note allows us to borrow the principal amount
thereunder  until  February  2, 2001. An amount equal to our qualified equipment
is  available  for  borrowing  under  this  note.  Amounts outstanding under the
equipment  line  of credit note accrue interest at the prime rate as reported in
the  Wall  Street  Journal  plus  one  and  one-quarter percent. With respect to
advances  made prior to November 6, 1999, principal and interest accrued thereon
are  payable in monthly principal amounts of $19,727 through and including April
15,  2002.  For  advances  made  after  November 6, 1999, principal and interest
accrued  thereon  shall be made in monthly principal payments of $35,607 through
and  including  October  15,  2002.  We  have  pledged  our  personal  property,
including  our  equipment,  trademarks  and  accounts receivable, to PNC Bank as
security  for  any  amounts  owed  by  us under these facilities. Under the loan
agreement,  we  are  generally restricted from incurring additional indebtedness
without  the  consent  of  PNC  Bank.  We  must  also maintain various financial
covenants,  including  minimum  cash  balance  and  certain financial ratios. In
addition,  we  may  not  declare or pay dividends or, make any distribution with
respect  to  any  equity  security during the term of the loan agreement without
the consent of PNC Bank.

     In  June 2000, we entered into a fifth amendment to our loan agreement with
PNC  Bank, in connection with a $3.0 million bridge loan for operating expenses.
In  connection  with  this  facility, we entered into a bridge note covering any
amounts  outstanding under the bridge loan. All outstanding borrowings under the
bridge  loan  together with interest accrued thereon will become due and payable
upon  the  earlier  of  (1)  December  19,  2000 and (2) the closing date of any
initial  public offering of our capital stock or any other equity event in which
we  receive an infusion of at least $3.0 million in cash or non-cash assets from
any  holder  of  our  capital  stock.  Generally, in the event that we raise any
funds  through  venture  financing, private placements of our equity securities,
or  strategic  investors,  we  are  obligated to make a prepayment on the bridge
loan  up to the maximum amount outstanding thereunder. Amounts outstanding under
the  bridge  loan  will  accrue  interest  at  the  prime rate plus 2.5%. We may
currently  draw  up  to  $1.5  million  and  up  to  $500,000,  in increments of
$250,000,  in  subsequent  months  up  to  the  $3.0 million maximum amount. All
borrowings  under  the  bridge  loan  will  be secured by our pledge of personal
property  under  the loan agreement. To date, we have not drawn down any amounts
under  this  facility and the face amount remains available to us. However, as a
result  of  our receipt of $10 million from our sale of Series B preferred stock
in  August 2000, as described below, we do not currently anticipate drawing down
any  amounts  under  this  facility  and  intend to let this facility expire. In
connection  with  the  bridge loan we issued to PNC Bank warrants to purchase up
to  15,030  shares  of our common stock. In the event that any amounts under the
bridge  loan  remain due on September 19, 2000, we are obligated to issue to PNC
Bank  warrants  for an additional 10,020 shares. The warrants are exercisable at
$5.99 per share, subject to adjustment for


                                       33
<PAGE>

certain  dilutive  issuances through June 2007. PNC Bank was also issued certain
registration  rights  enabling  them  to  request  to  include  the common stock
underlying their warrants in a registration statement filed by us.

     In  June  2000,  we  issued, in the aggregate, 557,191 shares of our common
stock  in  private  sale transaction with four accredited investors and received
cash compensation totalling approximately $3.6 million.

     On  August  16,  2000,  we  sold  950,747 shares of our Series B redeemable
convertible   preferred  stock  to  Amersham  Pharmacia  Biotech  for  aggregate
proceeds  of  $10.0  million  in cash. We expect to use the proceeds for working
capital.  At  the  time  of  issuance  of  the  Series  B redeemable convertible
preferred  stock,  the  deemed  fair market value of the underlying common stock
was  $15.00  per  share.  Therefore,  the  proceeds  of  $10.0  million  will be
initially  allocated  to  additional  paid-in  capital  as a presumed beneficial
conversion  feature  and  the entire amount of $10.0 million will be immediately
accreted  to  the  Series B redeemable convertible preferred stock on August 16,
2000.  These shares will automatically be converted into 1,587,747 shares of our
common  stock  at a conversion price of $6.30 per share immediately prior to the
closing of this offering.

     In  September  2000,  PNC Bank established an irrevocable standby letter of
credit  in  favor  of  Pacific  Gas & Electric Generating Company, in connection
with  our  execution  of  a  sublease  with  Pacific  Gas & Electric for our new
Bethesda,  Maryland  headquarters. The amount of this irrevocable standby letter
of  credit  will  not exceed $460,200, and such amount can be drawn in the event
that  we  are  in  default  under  the  sublease.  The amount of the irrevocable
standby  letter  of  credit  is secured by our deposit with PNC Bank of an equal
amount  of  cash that is designated solely for use under the irrevocable standby
letter  of credit. The irrevocable standby letter of credit expires on September
8,  2001.  In  connection  with  the  sublease for our Bethesda headquarters, we
anticipate  obtaining an additional irrevocable standby letter of credit, surety
bond  or  other  form  of  security  for  the  remainder  of  our  annual rental
obligation of approximately $1.35 million.

     We  believe  that  the net proceeds from this offering, our cash flows from
operations  and  our  existing  capital  resources  will be adequate to fund our
operations  for  the  next  24  months, although we may seek to raise additional
capital  during  that  period.  See  "Risk  Factors--We  may  require additional
funding  to  execute our business strategy. If that funding is not available, or
not  available  on terms acceptable to us, we may be required to curtail certain
marketing  and  product  development efforts" for a discussion of the investment
risks associated with the possibility of our need for additional financing.

RECENTLY ENACTED ACCOUNTING PRONOUNCEMENTS

     In  June 1998, the Financial Accounting Standards Board issued Statement of
Financial  Accounting  Standards No. 133, "Accounting for Derivative Instruments
and  Hedging  Activities, " which establishes accounting and reporting standards
for  derivative  instruments  and hedging activities. As amended by Statement of
Financial  Accounting  Standards No. 137, this standard will be effective for us
for  the years and quarters beginning after December 31, 2000, and requires that
we  recognize  all  derivatives as either assets or liabilities in the statement
of  financial  position and measure those instruments at fair value. We have not
completed  the  process  of  evaluating  the  impact  of  this statement and are
therefore  unable to predict the potential impact that implementing SFAS No. 133
will have on our financial position or results of operations.

     In  December  1999,  the  Securities  and  Exchange Commission issued Staff
Accounting  Bulletin  No.  101, Revenue Recognition in Financial Statements. The
SAB  expresses  the  SEC's  views  on  applying  generally  accepted  accounting
principles  to revenue recognition in financial statements. We do not expect the
application  of  the  SAB to have a material impact on our financial statements,
however,  certain  SEC  staff interpretations of the SAB have not been published
and  may  have  an  effect  on  the  applicability of the SAB in relation to our
consolidated financial statements.

     In  March  2000,  the  Financial  Accounting  Standards  Board  issued FASB
Interpretation  No.  44,  "Accounting  for  Certain Transactions Involving Stock
Compensation, an Interpretation of APB


                                       34
<PAGE>

Opinion  No. 25." With the exception of certain provisions that required earlier
application,  this  interpretation  is effective for all applicable transactions
beginning   July   1,  2000.  We  do  not  expect  that  the  adoption  of  this
interpretation will have a material impact on our financial statements.

QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

     Our  exposure  to  market  risk  for  changes  in  interest  rates  relates
primarily  to  the  increase or decrease in the amount of interest income we can
earn  on  our investment portfolio and on the increase or decrease in the amount
of  interest  expense  we  must pay with respect to our various outstanding debt
instruments.  Our  risk associated with fluctuating interest expense is limited,
however,  to  credit facilities that are closely tied to market rates. Under our
current  policies,  we do not use interest rate derivative instruments to manage
exposure  to interest rate changes. We ensure the safety and preservation of our
invested   principal   funds   by   limiting  default  risks,  market  risk  and
reinvestment  risk.  We  reduce  default  risk  by investing in investment grade
securities.  A  hypothetical  100  basis  point drop in interest rates along the
entire  interest  rate yield curve would not significantly affect the fair value
of  our  interest  sensitive  financial  instruments  at  December  31,  1998 or
December  31,  1999.  Declines in interest rates over time will, however, reduce
our  interest  income  and  expense  while increases in interest rates over time
will increase our interest income and expense.


                                       35

<PAGE>

                                   BUSINESS

OVERVIEW

     We  are  a  leading  global  provider  of bioinformatic software solutions.
Bioinformatics  involves  the  application  of  information  technology  to  the
analysis  of  genomic,  proteomic  and  other biomolecular data. Genomics is the
study  of an organism's genes, and proteomics is the study of proteins and their
role  in  particular diseases. Our bioinformatic software solutions are designed
to   enable  researchers  to  more  efficiently  organize,  share,  analyze  and
interpret these data that form the genetic blueprint of all organisms.

     We  believe that our position as a leading global provider of bioinformatic
software  is  based  upon the number of our customers, our revenues and the size
of  our  organization.  Since  introducing  our  Vector  NTI  Suite  of software
applications  for  desktop  computers in 1993, we have sold our products to over
1,300  organizations worldwide, including over 500 biotechnology, pharmaceutical
and  agricultural  biotechnology companies, and over 800 academic and government
research institutions. Our customers include:

       o Merck & Company,
       o Genzyme Corporation,
       o Procter & Gamble,
       o Johnson & Johnson,
       o Bristol-Myers Squibb,
       o Pfizer,
       o AstraZeneca,
       o Diversa Corporation,
       o Novartis Agribusiness Biotechnology Research,
       o the Whitehead Institute for Biomedical Research,
       o Massachusetts Institute of Technology,
       o University of Tokyo, and
       o the National Institutes of Health.

     Our  principal  software  products  are  our  Vector  NTI Suite for desktop
computers  and our more powerful and expensive GenoMax enterprise platform for a
network  of  computers  linked together for sharing data and computation. Driven
primarily  by  increased  sales  of  Vector  NTI  Suite  and the introduction of
GenoMax  in  late  1998, our products and complementary services generated $10.0
million  in  revenues  in  1999, representing a four-year compound annual growth
rate of 105%, and a 143% increase over 1998.

     Building  on  our  existing  market  penetration,  we  intend  to  grow our
business   through   increased  software  sales  and  add  new  revenue  through
professional   services,  content  channeling  and  distribution  alliances  and
e-commerce  offerings.  In  August  2000,  we entered into a long-term strategic
relationship  with Amersham Pharmacia Biotech, a subsidiary of Nycomed Amersham,
to  jointly  develop  and  market  an  expanded version of GenoMax to provide an
enterprise-wide  data  analysis  system  for  pharmaceutical  and  biotechnology
companies,  for  integrating  and  analyzing  data from genomics, proteomics and
drug screening production laboratories.

     As  of  September  27,  2000, we employed 205 people, including a sales and
marketing  team  of  54,  a  research  and product development team of 95 and an
implementation and support staff of 25.

INDUSTRY BACKGROUND

     Bioinformatics  combines  the  fields  of  molecular  biology,  information
technology,   and   Internet   communications.  Bioinformatic  software  enables
researchers,  using  automated  laboratory  research  techniques, to efficiently
organize,   share,   analyze,   and   interpret  genomic,  proteomic  and  other
biomolecular  data.  Genomic  and  proteomic factors dictate cellular functions,
susceptibility  to  disease,  and  physical  characteristics. Researchers expect
that  analysis  of  such  data  will  lead  to  new ways to diagnose, treat, and
ultimately  prevent  many  of  the  thousands  of  disorders that affect humans.
Genomic   research   involving   other  organisms,  including  plants,  animals,
bacteria,  and  viruses, could yield further advances regarding human disorders,
as  well  as  improvements  in agricultural production, industrial processes and
environmental management.

                                       36
<PAGE>

Research is Producing a Flood of Genomic and other Biomolecular Data.

     Around  the  world,  researchers  in industry, academia, and government are
producing  vast  quantities  of  biomolecular data. Much of this data is related
to:

   o DNA  sequence:  the  order  of  chemical subunits, called nucleotide bases,
     that  make  up  strands  of DNA found in the cells of every living organism
     and which encode genetic information;

   o gene   variation,  function  and  expression:  the  variation  in  specific
     sequences  of  nucleotide  bases  found  on chromosomes, called genes, that
     control  the  presence  of  hereditary  traits;  the biological function of
     those   sequences;  and  the  degree  to  which  a  gene's  information  is
     translated into the production of proteins within a cell; and

   o protein  structure  and  function:  the  sequence of chains of amino acids,
     the  building  blocks  of  proteins,  their  3D structures and the means by
     which  they  direct the regulation, growth and repair of cells, tissues and
     organs.

     Numerous   emerging   laboratory   technologies,   including  biochips  and
microarrays,  are  automating  and  accelerating  the generation of much of this
data. The following examples indicate the rapid increase in available data:

   o On   June   26,   2000,   the   Human   Genome  Project,  an  international
     collaboration  of  academic  and government research institutes, and Celera
     Genomics,  each pursuing the parallel goal of deciphering the human genome,
     jointly  announced  that they had assembled the world's first working draft
     of  the entire human genetic code, consisting of approximately 3.12 billion
     chemical nucleotide bases.

   o GenBank,  a National  Institutes of
     Health sponsored public  repository
     of genetic  sequences of humans and
     over   47,000   other    organisms,
     increased    from     approximately
     555,000 complete  sequences in 1995
     to  over   8.2   million   complete             [GRAPHIC OMITTED]
     sequences   as  of   August   2000.
     GenBank's  database  of  nucleotide
     bases increased from  approximately
     385  million  bases in 1995 to over
     9.5  billion  bases  as  of  August
     2000.  The parallel  chart reflects
     the growth in GenBank  data through
     August 2000.

Bioinformatic  Software  Efficiently  Stores,  Organizes  and Integrates Growing
Volumes of Biomolecular Data.

     A  central  problem  now  facing  researchers is how to store, organize and
integrate  complex  and  rapidly  growing  data sets. Bioinformatic software can
incorporate  a  relational  database, enabling researchers to efficiently store,
organize  and  search  proteomic and genomic data according to the properties of
relevant  data  objects. Bioinformatic software can also provide a user-friendly
interface   for   efficient  access  to  numerous  in-house  and  Internet-based
databases of biomolecular information.

Bioinformatic Software Transforms Primary Data into Useful Knowledge.

     The  true  value  of the rapidly growing mass of genomic and proteomic data
lies  in  the  transformation  of these data into advances in drug discovery and
development,   clinical   diagnostics,  agricultural  production,  environmental
management,  and industrial processes. Bioinformatic software allows researchers
to  incorporate  proprietary  and third party analytical algorithms and analysis
tools  to  interpret  and  translate  data into useful knowledge for application
across a variety of disciplines. Bioinformatic


                                       37
<PAGE>

software  can also automate database queries, analyses and reporting of research
results.  Automated  analysis  is  important  because  as biomolecular databases
grow,  researchers  must continuously update their analyses to reflect these new
data.

Bioinformatic Software Facilitates Collaboration among Researchers.

     Due   to   the  volume  and  complexity  of  biomolecular  data,  efficient
collaboration  among  researchers within and across organizations is required to
accelerate   productivity.   Within   large  pharmaceutical  companies,  related
research  efforts  are  often  conducted across numerous research departments in
different  locations.  The  Human  Genome  Project,  carried out at academic and
government  research  institutes  around  the  world,  represents  an example of
inter-organizational  collaboration. Internet and intranet-enabled bioinformatic
software  solutions such as our Vector NTI Suite and GenoMax enterprise platform
serve  as  an information bridge allowing researchers to share data and results,
collaborate in analyses and better coordinate their efforts.

Bioinformatic  Software Provides an Efficient Interface for Online Data Sources.

     Currently,   researchers  can  access  over  500  public  domain  databases
containing  genomic,  proteomic  and  other biomolecular data over the Internet.
For  example,  the National Center for Biotechnology Information (NCBI) provides
access  to  GenBank  and its other databases through its Internet website, which
is  used  on  average  by  more  than  140,000 users per weekday who initiate an
average  of over 4 million queries per day. In addition, commercial providers of
genomic,  proteomic  and  other  biomolecular  data often provide customers with
access  to proprietary data through the Internet. Bioinformatic software can act
as  a  researcher's  interface  with diverse online databases. The Internet also
enables  the  distribution  of  bioinformatic software, the use of bioinformatic
software  maintained  on  remote  computers, and the online purchase of products
used in laboratory experiments.

MARKET OPPORTUNITIES IN BIOINFORMATICS

The Market for Bioinformatic Software is Large and Increasing.

     An  August  2000  independent  industry  report  by  Front  Line  Strategic
Management   Consulting   estimates   the   world-wide   bioinformatics  market,
consisting  of sales by providers of analytical software, enterprise systems and
data,  at  approximately  $468  million  in  2000, growing to approximately $2.0
billion  in  2005  and  approximately $5.4 billion in 2010. We believe that this
growth  is  being  driven  in  part  by  organizations  increasingly  turning to
external  vendors of bioinformatic software solutions, allowing them to focus on
their   core   research   competencies.   We  believe  that  market  growth  for
bioinformatic  software  solutions  is  driven  by several factors common to all
industries engaged in biological research, including:

   o the  difficulty  of managing and integrating the rapidly increasing volumes
     of available biomolecular data;

   o increased  demand  for  productivity  and  cost  efficiency  by researchers
     engaging in biological discovery;

   o the  advantages  of making front-end technology investments to avoid costly
     failures later in the research and development process; and

   o the   opportunity   to   claim   valuable  patent  rights  on  biomolecular
     information    underlying    diseases,    human    behavior,   agricultural
     productivity,  environmental  management,  industrial  processes, and other
     areas.

     We   believe  that  our  software  products  provide  researchers  with  an
efficient  means  by  which  to  access disparate data sources and give them the
tools  to  rapidly interpret, analyze and translate such data for application in
numerous   disciplines.   Given   the   market   opportunities  created  by  the
applications  of  genomic,  proteomic  and  other  biomolecular  data,  and  the
efficiency  and  productivity  gains  that  can  be  achieved through the use of
bioinformatic  software,  we  believe that the market for our software solutions
will continue to increase.


                                       38
<PAGE>

Target Markets for Bioinformatic Software Applications

     Bioinformatic   software   facilitates   increased   research   efficiency,
productivity  and  collaboration  in  the numerous disciplines that apply a data
driven,   genomic   approach  to  biological  discovery.  In  1997,  there  were
approximately   373,500   scientists  and  engineers  engaged  in  research  and
development  in  the life sciences and related science fields, including 171,700
in  commercial  organizations  and  201,800  in academic and government research
institutions.  We  believe that the current and future markets for bioinformatic
software  products  include  all  of the industries participating in the genomic
revolution, including:

       Pharmaceutical   and   Biotechnology   Companies.   There  are  over  250
   pharmaceutical  companies  and  2,000  biotechnology  companies worldwide. In
   1999,  pharmaceutical  companies  are  estimated  to have spent approximately
   $20.1  billion  in  research  and  development in the United States alone. In
   addition,   U.S.   biotechnology   companies  are  estimated  to  have  spent
   approximately  $9.9  billion  in  research and development. Current estimates
   suggest  that  over  90%  of  potential drug candidates fail at some point in
   the  development  process  and  that  bringing  a  new  drug  to market costs
   approximately   $500   million  and  requires  an  average  of  15  years  in
   development.  In  an  effort to increase the number and quality of marketable
   drug    candidates,    pharmaceutical   and   biotechnology   companies   are
   increasingly  moving  away  from the trial-and-error approach of conventional
   laboratory  research  to  a  more effective, data-intensive, genomic approach
   to drug discovery.

       Academic  and  Government  Research Institutions. Academic and government
   research  institutions,  including  the  international institutions that make
   up   the   Human  Genome  Project,  have  been  significant  participants  in
   biomolecular  research  and  the  advancement of genomics. Public spending on
   such  research  is  expected to increase rapidly over the next several years.
   Government  funding  for  the  National  Institutes  of Health increased from
   $13.6  billion  in  1998 to $15.6 billion in 1999. The National Institutes of
   Health  budget,  over  65% of which is expected to fund grants to researchers
   and  support  internal  research  efforts, is expected to reach $17.8 billion
   in 2000, a 14% increase over 1999.

       Agricultural,   Environmental  and  Industrial  Biotechnology  Companies.
   Greater  knowledge  about  plant and animal genomes may enable researchers to
   engineer  stronger,  more  disease resistant plants and animals, resulting in
   increased  farming  and  livestock  productivity.  Researchers  may  use such
   knowledge  to  develop more nutritious and pesticide free foods and cultivate
   enzymes  that  aid  in  industrial processes and environmental management. By
   reducing   discovery   and  development  costs,  bioinformatic  software  may
   facilitate    the    creation    and   commercialization   of   agricultural,
   environmental  and  industrial products and technologies that might otherwise
   be cost prohibitive and therefore unable to gain broad market acceptance.

       Emerging   Clinical   Genomics  Industry.  Industry  participants  expect
   genomics  and  the  study  of genetic variation to play a central role in the
   market  for  clinical diagnostics and the emerging market for customized drug
   therapies.  Through  the  analysis  of  genomic data, researchers are gaining
   improved  understanding  of  disease  onset  and  progress and are working to
   translate  these  findings  into  earlier-stage  and more accurate diagnostic
   tests.  In  addition,  researchers  engaged  in the emerging pharmacogenomics
   field  are  seeking  to determine how the millions of tiny genetic variations
   among   individuals   impact  drug  response,  and  thereby  develop  a  more
   personalized approach to medicine.

OUR SOLUTION

     In  response  to  the  challenges and market opportunities presented by the
genomic  revolution,  we  develop  and  deliver  to our customers a portfolio of
proprietary bioinformatic software products and complementary services.

     Our  software  products  are  flexible  and  scalable  and  are designed to
integrate  with  one another. Our software products provide access to public and
commercial  databases  and  are designed to provide e-commerce connectivity with
vendors  of  laboratory reagents for use in actual experiments. Our products are
designed   to   be  stand-alone  applications  or  Internet-hosted  applications
provided  through  application  service  providers.  Our  current  and announced
product portfolio includes:

   o Vector  NTI  Suite,  a  comprehensive  desktop  analysis  and visualization
     toolset  for  the  laboratory  scientist  engaged  in  genomic  and protein
     sequence research. Vector NTI Suite

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<PAGE>

     contains  modules  that  enable  researchers to store, manage, assemble and
     analyze  biomolecular  data.  Vector  NTI  Suite is designed to reflect and
     simulate  the  workflow  and  analytical  processes  used  by  a laboratory
     researcher.  Launched  in  1993,  Vector  NTI  Suite  is  offered  for both
     Microsoft  Windows  and  Apple Macintosh operating systems. To date we have
     sold  over  9,000  licenses  for  Vector  NTI  Suite, with more than 20,000
     estimated users, to over 1,300 organizations engaged in genomic research.

   o Vector  Enterprise,  designed  for researchers working in larger groups, or
     who  collaborate  with others on sequence analysis projects. Using a shared
     Oracle  relational  database,  Vector  Enterprise  is an enhancement to the
     Vector  NTI  Suite  that allows users to share data and results in a secure
     environment.  We  commercially  released Vector Enterprise on September 29,
     2000.

   o GenoMax,  a  large-scale  modular,  enterprise-wide data mining application
     that  integrates  multiple  genomic  data  types and enables researchers to
     automate   complex   analysis   tasks.   GenoMax   enables  researchers  to
     efficiently   store,   search,   manage   and   analyze  large  amounts  of
     biomolecular  data.  GenoMax  facilitates  research  collaboration  and  is
     designed  for  a  coordinated effort by a diverse team of scientists within
     or  across  organizations.  Since  its launch in late 1998, we have made 20
     sales of GenoMax.

     Through  the  continued  expansion and enhancement of our product offerings
to  meet  the  needs  and preferences of our customers, we seek to establish our
software   products   as  the  effective  industry  standard  for  bioinformatic
solutions.

OUR ADVANTAGES

     We  believe  that  our competitive strengths, including those listed below,
position  us  to  continue  to  be  a  global  leader  in bioinformatic software
solutions:

Superior Products and a Broad Product Portfolio

     Benefiting  from  years  of  user  feedback,  we  have tailored our product
portfolio  to  meet  the  current  and  anticipated  needs  and  preferences  of
biomolecular  researchers. Our software solutions are flexible and scalable, can
integrate  with  each  other  and  can  incorporate  proprietary and third party
analytical  algorithms  and  data  sets. Our products contain advanced analysis,
visualization  and  simulation  tools  and  reflect  the natural workflow of the
laboratory  scientist.  Our  product  portfolio  includes  Vector  NTI Suite for
individual  researchers or groups of researchers, via our Dynamic License Server
which  provides  numerous  users  concurrent  access  from a centralized server.
Vector  Enterprise  provides  a  Vector NTI Suite user group with the additional
advantages  of  a  shared  relational  database. GenoMax is a modular enterprise
platform  that  can scale to meet the needs of smaller biotechnology or academic
customers  as  well as major pharmaceutical companies and research institutions.
We   believe   that  our  broad  product  offering  and  the  sophisticated  and
user-friendly  functionality  of our products give us a competitive advantage in
the market for bioinformatic solutions.

Superior Bioinformatic Engineering Staff

     Software   engineering   for  commercial-grade  bioinformatic  applications
requires  a  high  level  of  understanding  of  software programming, molecular
biology  and market requirements. Our development teams are guided by experts in
molecular  biology  and  include  professional  software  engineers  trained  in
computer  science, statistics, mathematics, and physics. Our product development
staff  has  functional  expertise  in  C/C++,  Java, MS Windows, Apple OS, UNIX,
object-oriented  design,  system-level  programming,  relational database design
and  development  (including  Oracle),  graphical  user  interface  programming,
bioinformatics  and  molecular biology. Our product development staff has played
a  significant  role  in  developing a customized data delivery platform for the
NCBI's  GenBank,  ENTREZ  and  PubMed/MEDLINE  online  genomic  databases. As of
September  27,  2000,  we  had  95 employees dedicated primarily to research and
product development.


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<PAGE>

Large Existing Customer Franchise

     We  are  currently  a  leading  provider of bioinformatic software and have
attained   a   significant  level  of  industry  acceptance  for  our  products.
Introduced  in  1993, we have sold over 9,000 licenses for our Vector NTI Suite,
with  more  than  20,000 estimated users, to over 1,300 commercial, academic and
government  research  institutions,  including  almost  all major pharmaceutical
companies  and  over 400 biotechnology companies. Since its introduction in late
1998,  we  have  made  20  GenoMax  sales  to pharmaceutical, biotechnology, and
academic  customers,  including  DuPont,  Pioneer  Hi-Bred  International, Inc.,
Genzyme  Corporation,  BASF AG, the Whitehead Institute for Biomedical Research,
Massachusetts  Institute  of  Technology  and  the  University  of  Tokyo. Since
October  1994, we have provided software development services to the NCBI at the
National  Institutes  of  Health,  the leading public sector provider of primary
genomic and biomolecular data.

Vector  NTI  Suite's  Market  Penetration  which  Creates  Opportunities for New
Products and Business Lines

     Our  Vector  NTI  Suite  represents  an important strategic and competitive
advantage,  providing buyers with a lower cost means to validate the quality and
utility  of  our  software  solutions.  Moreover,  our  desktop  and  enterprise
applications  integrate with one another and allow researchers to share data and
research  results between the applications. We believe that connectivity between
desktop  and  enterprise  solutions and vendor familiarity are important factors
in  the  selection  of  an  enterprise solution. We believe that for many of our
1,300  Vector  NTI  Suite  customers,  these considerations will give GenoMax an
important  advantage  over  competing  enterprise  platforms. Of our 20 sales of
GenoMax,  16  were to existing users of our Vector NTI Suite. We believe that we
can  leverage  our  significant  Vector  NTI Suite customer base to add revenues
through  new  products  and  business  lines,  including additional professional
services,   content   channeling  and  distribution  alliances,  and  e-commerce
offerings.

Superior Sales and Marketing Capabilities

     We  have  funded  our growth primarily with internally generated cash flow.
As  a result, our sales and marketing team is focused on execution and committed
to  achieving leadership in the markets we serve. We have built an aggressive 54
person  sales  and  marketing  organization  whose  mission  is to establish our
products  as  the  standard in the bioinformatics industry. In an effort to gain
further   market   penetration   and  increase  our  brand  awareness,  we  have
co-marketed  our products with technology leaders, including Compaq, Oracle, and
Sun   Microsystems.  In  August  2000,  we  entered  into  joint  marketing  and
development   agreements  with  Amersham  Pharmacia  Biotech,  a  life  sciences
technology  company.  We  currently  maintain  a  staff of 25 representatives to
provide  software  implementation  and  integration  services  and technical and
customer  support to our existing customer base. In an effort to ensure that our
development  pipeline  satisfies  evolving market needs and preferences, leaders
from  our  product  development,  implementation  and  support,  and  sales  and
marketing teams regularly share customer feedback.

OUR STRATEGY

     Our  goal  is  to  become  the  leading  provider of bioinformatic software
solutions  and  establish  our  products  as  the  effective  industry standard.
Elements of our strategy to achieve these goals include:

Expand Our Customer Franchise Through Sales of Vector NTI Suite

     We  have  expanded  our  Vector  NTI  Suite  customer  base  to  over 1,300
organizations.  We  intend  to  expand and further penetrate our existing Vector
NTI  Suite  customer  base.  To  execute this strategy, we intend to continue to
improve  our  technologies  and  introduce  advanced functionality to Vector NTI
Suite,  including  enhanced Internet connectivity. We also intend to broaden our
sales  and  marketing efforts and establish and expand upon our co-marketing and
strategic relationships in order to expand our desktop customer base.


                                       41
<PAGE>

Build  on  Vector  NTI  Suite's  Market  Penetration to Establish GenoMax as the
   Leading Enterprise Platform

     We  intend  to  leverage the market acceptance of Vector NTI Suite to build
recognition  and  penetration  of  our  GenoMax  enterprise  platform. Of our 20
GenoMax  sales,  16  were  to  existing  users  of  our  Vector  NTI  Suite.  We
commercially  released  our  Vector Enterprise product on September 29, 2000 and
we  expect to employ a similar strategy of leveraging the existing acceptance of
our  Vector  NTI  Suite.  We  also  intend  to  continue  to establish strategic
industry  relationships  that  validate the effectiveness and utility of GenoMax
and maximize market opportunities for our enterprise bioinformatic products.

Leverage Our Customer Base for New Business Lines

     We  intend  to  leverage  our  significant  customer  base  to add revenues
through  various  sources  including  new  business  lines  and  services. These
offerings include:

     Professional    Services.    We    provide    installation,    integration,
customization,  maintenance, support and user training to our GenoMax and larger
Vector  NTI  Suite customers on a fee for service basis. We believe that we will
be  able  to  increase  market penetration and customer loyalty for our software
solutions  by  increasing  the value-added professional services that we provide
to our customers.

     Channeling  and  Distribution  Alliances.  We  seek to enter into alliances
with  selected data content and technology providers and to integrate and market
their  biomolecular  data  and specialized bioinformatic hardware along with our
software  products.  To  date,  we  have  entered into four agreements to resell
third party genomic content or technology hardware.

     e-Commerce  Offerings.  Vector  NTI  Suite allows researchers to design and
simulate  laboratory  experiments  and provides researchers with recommendations
for  reagents,  enzymes and other specific genomic material necessary to execute
actual  laboratory  experiments.  We  intend  to incorporate Internet hyperlinks
into  Vector  NTI  Suite  that  will  enable  users  to purchase these materials
directly  from  partnered  vendors.  We expect to generate transaction fees from
our  partnered  vendors  for providing them access to our user base at the point
of their research decisions.

Enhance and Expand our Technology

     We  intend  to  continue  to  enhance and expand our bioinformatic software
products  and  technology  to  meet  evolving customer needs and preferences. We
intend  to aggressively attract and retain additional personnel for our research
and  product development group including skilled software engineers, information
technology  professionals  and  experts  in  molecular biology. On September 15,
2000,  we  commercially  released  GenoMax  3.0  containing  significant product
enhancements.  On  September  29,  2000,  we  commercially  released  our Vector
Enterprise  product  for  use  in  collaborative  sequence analysis projects. We
intend  to  pursue  opportunities  to  develop  products  for  new applications,
including clinical diagnostics and personalized drug therapy.

Establish Strategic Relationships to Maximize our Revenues

     We  intend  to enter into strategic relationships with selected partners to
expand our customer base and product distribution channels, including:

   o Co-Marketing  Relationships.  We intend to continue to establish and expand
     our  co-marketing  relationships  with  leading organizations in our target
     markets.  We  believe  that these relationships will significantly increase
     global  market  awareness  of  and receptivity to our software products. We
     have   established   co-marketing  relationships  with  technology  leaders
     including  Compaq, Oracle, and Sun Microsystems. In August 2000, we entered
     into  joint  marketing  and  development agreements with Amersham Pharmacia
     Biotech, a life sciences technology company.

   o Internet-hosted  Software  Delivery  Alliances.  We  intend  to provide our
     customers  with  access  to  our  software products through Internet-hosted
     services.  We  expect that by providing our software through an application
     service  provider's  Internet-based  network, we will be able to accelerate
     the


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<PAGE>

     the  deployment and facilitate the management of our software solutions. In
     January  2000,  we  entered  into  an agreement with an application service
     provider  and,  in  the  third  quarter  of 2000, we made our bioinformatic
     software solutions available through its Internet-based hosting network.

Engage in Acquisitions and Strategic Investments

     Where  appropriate,  we will pursue acquisitions and strategic investments,
both  domestically  and internationally, to enter new markets and accelerate the
development  of comprehensive solutions to our customers' needs. We believe that
through   acquisitions  and  strategic  investments,  we  may  be  able  to  add
complementary  technologies,  products  and  services,  and  expand our customer
base.

                                       43
<PAGE>

OUR PRODUCT AND SERVICE LINES

                               SOFTWARE PRODUCTS
--------------------------------------------------------------------------------

 VECTOR NTI SUITE: suite of desktop applications
designed for individual scientists engaged in
genomic and proteomic
  research

<TABLE>
<CAPTION>
 VERSION                  MODULES           FUNCTIONS
<S>                       <C>               <C>
 VECTOR NTI SUITE 6.0     VECTOR NTI        data analysis and visualization
 (released Q2 2000)       BIOPLOT           sequence analysis
                          ALIGNX            multiple sequence alignments
                          CONTIGEXPRESS     sequence fragment assembly
                          3D MOL            structure analysis and visualization

<S>                                                <C>
 VECTOR ENTERPRISE (released Q3 2000):
                                                   incorporates a shared relational database into a network of Vector
                                                   NTI Suite applications to enable real-time collaboration among multiple
                                                   researchers in a secure environment

GENOMAX ENTERPRISE: large-scale, modular, enterprise-wide data mining and analysis application
</TABLE>

<TABLE>
<CAPTION>
 VERSIONS                       MODULES                               FUNCTIONS
<S>                             <C>                                   <C>
 GENOMAX 3.0                    SEQUENCE ANALYSIS                     similarity searches, sequence alignments and annotation
 (released Q3 2000)
                                GENE EXPRESSION ANALYSIS              management and visualization of microarray data
                                PROTEIN 3-D STRUCTURE                 analysis and prediction of protein molecular structure

 FUTURE GENOMAX VERSIONS        GENOME VIEWING                        chromosome and expressed sequence tag (EST) mapping
                                PROTEIN-PROTEIN INTERACTION           analysis of protein intracellular behavior
                                SNP ANALYSIS                          genetic variation analysis
-----------------------------------------------------------------------------------------------------------------------------
</TABLE>

                             PROFESSIONAL SERVICES
<TABLE>
<CAPTION>
--------------------------------------------------------------------------------
                                     Consulting and software development
 SOFTWARE DEVELOPMENT                  services provided under contract
<S>                                  <C>
 IMPLEMENTATION AND                  Software installation, integration
                                     and customization for GenoMax
                                     customers
 SUPPORT SERVICES
--------------------------------------------------------------------------------

</TABLE>

                     CHANNELING AND DISTRIBUTION ALLIANCES

<TABLE>
<CAPTION>
--------------------------------------------------------------------------------
                                        Partnerships to integrate and
                                     distribute third party data content
                                              and to distribute
 CONTENT CHANNELING AND               specialized bioinformatic hardware
 HARDWARE RESELLING                           with our software
<S>                                  <C>
 E-COMMERCE PARTNERING               Partnerships to enable Vector NTI
                                     Suite customers to use hyperlinks to
                                     make
                                     online purchases of laboratory
                                     reagents, including those specified
                                     by Vector NTI
                                     Suite's decision support functions
</TABLE>


                                       44
<PAGE>

Software Products

     Our  portfolio of software products currently includes our Vector NTI Suite
desktop  application,  our  Vector Enterprise product and our GenoMax enterprise
platform.


 Vector NTI Suite

     Vector  NTI Suite is a comprehensive, integrated analysis and visualization
software  toolset  for  scientists  working  with genomic and proteomic data. We
launched  our  first  desktop  application in 1993 and released Vector NTI Suite
6.0,  our  sixth  generation  desktop  product,  in  June 2000. Vector NTI Suite
consists of five modules, each of which is described below:

   o Vector  NTI.  Vector NTI provides the desktop researcher with bioinformatic
     tools   to   create,   analyze,  map,  manage,  and  graphically  represent
     biological  data.  Vector  NTI incorporates an object-oriented database for
     the  storage  and  organization  of  DNA  and  protein  sequence  data  and
     biomolecular  materials  used  in  the  cloning  of disparate DNA molecules
     called  recombinant  cloning.  These  recombinant cloning materials include
     vectors,  plasmids, oligonucleotides, gel markers, and restriction enzymes,
     which  can be organized and stored. The database can be sorted, customized,
     and  searched  according to the properties of relevant data objects. Vector
     NTI  has  the  ability  to design recombinants based on built-in biological
     knowledge  and  selected user preferences which accelerates the complex and
     time-consuming  process  of  designing  cloning  experiments. By developing
     cloning  strategies  before  performing  actual laboratory work, users save
     valuable  research  time,  reduce  reagent costs, and enhance the prospects
     for  a  successful  cloning  experiment.  Through  its simulation function,
     Vector  NTI  recommends  necessary  protocols  and reagents to complete the
     experiment.  Vector  NTI  includes tools for cutting DNA sequences known as
     restriction  enzyme  analysis  and for amplifying a DNA sequence called PCR
     primer  design.  Vector  NTI  also  enables  the  study  and  induction  of
     mutations   known  as  mutagenesis  analysis  and  the  separation  of  DNA
     fragments  and  proteins  called  gel electrophoresis. Through Vector NTI's
     sophisticated  graphical  user  interface,  researchers can visualize their
     data and results of analysis.

   o BioPlot.  BioPlot  is  a  protein  and  nucleic acid sequence analysis tool
     that  plots  more  than  fifty  different pre-defined physical and chemical
     protein  analysis  types  and  links  them  with  feature  maps  and actual
     sequences.  Amino  acid scaling allows visualization of the distribution of
     the  structural  and  chemical  properties of amino acids along a molecular
     chain,  providing  clues as to the functional properties of protein regions
     or  domains.  These functional properties allow researchers to more quickly
     identify and understand regions of interest in molecules under study.

   o AlignX.  AlignX  allows  researchers  to  create and edit multiple sequence
     alignments  of proteins or nucleotides. The multi-pane view allows relevant
     domains  in  individual  sequences  to be linked, localized and compared in
     their  alignment  and  in  plots  of  similarity  and  sequence complexity,
     referred  to  as  homology.  AlignX integrates actively with Vector NTI and
     can  read  a multitude of data formats, a capability common to every module
     in the Vector NTI Suite.

   o ContigExpress.  ContigExpress  allows  the  user  to  take  small  analyzed
     sequence   fragments,   either   in   text   format   or   from  sequencing
     chromatograms,   the   output  from  automated  sequencing  equipment,  and
     visually  assemble  them  together  into  a  longer,  contiguous  sequence.
     ContigExpress  further allows the user to edit the fragments directly, with
     the  chromatograms  in full view, while it tracks all the changes made. The
     ability   to  simultaneously  show  sequence  and  trace  data  allows  the
     researcher   to   inspect   the   relative   intensity  of  the  sequencing
     chromatogram and modify the called base, if needed.

   o 3D  MOL.  Released  as  part  of  Vector  NTI  Suite 6.0, this tool enables
     researchers  to  analyze  and  visualize molecule structures using numerous
     display  modes.  3D  MOL enables researchers to manipulate the 3D structure
     of  protein  and  DNA  sequences  correlated  to their constituent to amino
     acids  and  nucleotide  sequences. The analytical features of 3D MOL enable
     researchers to measure distances and angles within molecules.


                                       45
<PAGE>

  Benefits of Vector NTI Suite

     The benefits of our Vector NTI Suite include:

   o Integrated  Software  Suite.  Vector  NTI Suite includes a fully searchable
     database   template  that  allows  researchers  to  store  and  manage  DNA
     sequences,  protein molecules, enzymes, and other biomolecular data. Vector
     NTI  Suite  allows  users  to perform analyses involving several integrated
     applications  and  to store and move data objects between the components of
     the desktop suite without reformatting between applications.

   o Open  Architecture.  Vector  NTI  Suite  is  offered  for  both Windows and
     Macintosh  operating  systems  and  can  accommodate  data in numerous text
     formats  used  in  the  research  world  including  FASTA,  GenBank,  EMBL,
     SWISS-PROT,  GenPept  and  ASCII. The software can run from a single static
     license  for  one  machine  or  with  our  Dynamic  License Server that can
     allocate   a  pre-defined  number  of  users  running  the  software  on  a
     centralized  server.  The Dynamic License Server creates an easily scalable
     environment,  where  the number of concurrent licenses can be set according
     to the expected usage.

   o Research  Logic  System  Reflects  Scientists' Natural Workflow. Vector NTI
     Suite   eliminates   many  of  the  time-consuming  laboratory  design  and
     execution  processes  by  generating  protocols and suggestions for cloning
     strategies,  PCR  primers  and  DNA  fragment assembly called oligo design,
     restriction  fragment  analysis,  mutagenesis analysis, protein and DNA/RNA
     analyses,  multiple  sequence  alignments, and contig assembly. Researchers
     are  also able to use the graphical features of Vector NTI Suite to produce
     presentation quality materials describing the results of their research.

   o Internet  Connectivity.  Vector  NTI Suite provides connectivity to over 20
     Internet  sites  for searching and importing fully annotated molecules back
     into  Vector  NTI  Suite  for further manipulation and analysis. Vector NTI
     Suite  can  analyze  these  data  along  with  data collected from internal
     research  as well as data from other publicly available sources. Vector NTI
     Suite  6.0  incorporates  enhanced  Internet  connectivity, providing users
     with  e-commerce  capability  directly  through  our software. We intend to
     enter  into  partnering arrangements by which this feature will allow users
     to  purchase  through  the  Internet reagents suggested by Vector NTI Suite
     and  other  biomolecular  material  necessary  to conduct actual laboratory
     experiments.

   o Transparent  Data  Searching.  Vector  NTI  Suite 6.0 allows researchers to
     conduct  BLAST  homology  searches  and query the ENTREZ and PubMed/MEDLINE
     databases  at the NCBI through the desktop application without the need for
     a  web  browser.  BLAST is the NCBI's basic local alignment search tool and
     involves  the use of an algorithm to search online databases to compare any
     newly  discovered DNA or protein sequence with known sequences. The results
     of   this   algorithm,  which  allows  the  identification  of  regions  of
     similarity  between  sequence data, can be stored and managed by Vector NTI
     Suite.  The  ENTREZ  and PubMed/MEDLINE search system allows researchers to
     search  the  NCBI  databases  of  biomolecular  data and perform scientific
     literature  searches. Results of such searches can be stored and managed by
     Vector NTI Suite for later use or presentation.

   o Application  Facilitates  Research  Collaboration.  Vector NTI Suite allows
     researchers  to  share  and  exchange  data and research results from their
     individual  databases between several installations of Vector NTI Suite. In
     addition,  Vector  NTI  Suite  supports  special document types that can be
     used   as   "packagers"   for  heterogeneous  data  and  research  results.
     Geographically  distributed  users  may  exchange  these  documents and use
     Vector  NTI  Suite's  graphical  viewers to visualize each others' research
     results.


 Vector Enterprise

     Our  Vector Enterprise database software is designed for biologists working
in  larger  research  groups,  or  those  who  need to work collaboratively with
others  on  sequence  analysis  projects. Vector Enterprise is an enhancement to
the  basic Vector NTI Suite and relies on a shared Oracle relational database to
store  user  data and results. This product is coupled with the desktop database
already


                                       46
<PAGE>

present  in  the Vector NTI Suite and permits multi-user access and data sharing
across  entire  companies  or  organizations by all researchers using Vector NTI
Suite,  with  secure  data  storage  and  analysis. We commercially released the
first version of Vector Enterprise on September 29, 2000.


 GenoMax Enterprise Solutions

     GenoMax  is  a  large-scale,  enterprise-wide, data-mining application that
enables  research  organizations  to  store, manage, integrate and analyze large
amounts   of   genomic  and  proteomic  data  from  disparate  sources.  GenoMax
incorporates  proprietary  and third party analytical tools that perform complex
integrated  analyses  across  multiple experiment types that are not possible on
desktop  programs.  GenoMax  relies  upon our user-friendly, Java-based Research
Logic  interface system and maintains an open architecture that allows new tools
and  proprietary  algorithms  to be incorporated into the GenoMax framework. The
GenoMax  architecture  supports access to the system through Intranet, wide area
network  or  dedicated Internet connectivity, while preserving data security and
integrity.  GenoMax  enables  multiple  users  to  collaborate in the design and
execution  of  research ranging from molecule analysis and annotation to complex
bioinformatic  algorithms.  The  combination  of a collaborative environment and
sophisticated   data-mining   and   management  capabilities  makes  GenoMax  an
effective tool for coordinated genomics research.

     GenoMax  was originally launched under the brand name Software Solution for
Bio-Medicine  in September 1998. GenoMax 3.0, which was commercially released on
September  15, 2000, includes a gene sequence analysis module with functionality
including  database  similarity searches, multiple sequence alignments, sequence
annotation  and visualization, and restriction enzyme analysis. GenoMax 3.0 also
includes  enhancements  such  as  fully distributed computing for analyses, data
management  and  storage  in  order to achieve improved scalability and to fully
utilize a client's existing computing infrastructure.


  GenoMax Enterprise Solutions Modules

     The  following  describes  modules that are included in GenoMax 3.0 as well
those  modules  that are currently in development and expected to be included in
future versions of our GenoMax enterprise solution:

   o Sequence  Analysis:  for  database  similarity searches including BLAST and
     FASTA,    multiple    sequence    alignments,   sequence   annotation   and
     visualization,  restriction  enzyme  analysis,  automated search agents and
     proprietary  sequence comparison tools. This module is available as part of
     GenoMax 3.0.

   o Gene  Expression  Analysis:  for  management, analysis and visualization of
     microarray data. This module is available as part of GenoMax 3.0.

   o Protein  3D  Structure:  for prediction and analysis of tertiary structures
     of  proteins  including  molecular  structure.  This module is available as
     part of GenoMax 3.0.

   o Genome  Viewing:  for  visualization  and  analysis  of chromosome maps and
     mapping  of expressed sequence tag (EST) clusters, transcripts, and genomic
     sequences. This module is currently in development.

   o Protein-Protein   Interactions:   for  analysis  of  protein  intracellular
     behavior. This module is currently in development.

   o Single  Nucleotide  Polymorphism (SNP) Analysis: designed to manage rapidly
     growing  volumes of data on these tiny genetic variations, this module is a
     key  analysis  tool  for  research  in  pharmacogenomics.  This  module  is
     currently in development.


  Benefits of GenoMax

     The benefits of our GenoMax enterprise solution include:

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<PAGE>

   o Collaboration-Oriented  Architecture.  GenoMax  is a client-server software
     solution   that  allows  collaboration  within  and  across  organizations.
     Multiple  users  may  simultaneously search and analyze large quantities of
     data  and  share their results. Computationally intensive algorithms run on
     the  server  side,  while  the  results  are  delivered  on the client side
     through   an   intuitive  Java-based  graphical  user  interface,  enabling
     real-time  feedback  with  the  central server, other users, and with third
     parties.  GenoMax secures research analyses behind a corporate firewall and
     incorporates  a  flexible hierarchy of user rights, giving managers control
     of  research  projects  and  permitting  administrators  to customize their
     security needs by adding and deleting authorized users as necessary.


   o Large-Scale   Data  Processing  /  High  Throughput  Research.  GenoMax  is
     designed  to  accommodate  the  needs of research institutions that analyze
     large  amounts  of  genomic,  proteomic and biomolecular data from multiple
     sources.  The  Oracle  relational  database  system that is integrated into
     GenoMax  automatically  updates  databases  from  public  and  subscription
     sources  and  includes alert mechanisms that notify users when new data has
     been  imported.  Data  can be accessed and analyzed by researchers manually
     or  automatically  through  GenoMax's High Throughput Research system which
     allows  researchers  to  create  sophisticated analysis protocols and apply
     them to process data on a 24-hour basis.


   o Flexible   Bioinformatic  Framework.  GenoMax  supports  a  wide  range  of
     data-mining  algorithms,  including  BLAST,  FASTA,  HMM,  flexible pattern
     search,  ORF  analysis,  and homology blocks search. GenoMax's architecture
     is  open,  scalable,  secure, and easily extended so that our customers may
     incorporate   client-developed   and   publicly  available  algorithms  and
     solutions.  To  enhance  efficiency, GenoMax includes data management tools
     for  organized storage and analysis and employs results filtering to select
     the most useful results according to user specifications.


Professional Services


     Software  Development.  As  part of our growth strategy, we have developed,
and  intend  to  expand,  our partnerships with genomic content providers. These
relationships  provide  us  with  additional revenue opportunities, and broaden,
validate,  and  reinforce  our bioinformatic capabilities and brand recognition.
Since  October 1994, we have provided software development services to the NCBI,
a  division  of  the  National Library of Medicine at the National Institutes of
Health.  NCBI  maintains  the  world's  largest  databases  of genomic and other
biomolecular  data,  which  are  available  via the Internet to all participants
engaged  in  genetic  and biological research. We have played a significant role
in  the  development  of  the  public content delivery interfaces for the NCBI's
databases,  including GenBank, ENTREZ, and PubMed/MEDLINE. Our relationship with
NCBI  allows  us  to  work  with  the  world's  largest genomic and biomolecular
databases,  covering  diverse  sets  of  information.  NCBI  contracts for these
services  through  intermediaries  for  whom  InforMax is a subcontractor. These
government contracts may be terminated on the behalf of the NCBI at any time.


     Implementation   and  Support  Services.  Our  implementation  and  support
services   group   provides   installation,   integration,   customization,  and
maintenance  support to our customers. We provide professional services on a fee
for  service  basis  for  our GenoMax and larger Vector NTI Suite customers. Our
implementation   and   support   group  includes  professionals  experienced  in
implementing  our  software  in conjunction with systems manufactured by leading
technology  companies including Compaq, Oracle, and Sun Microsystems. We respond
to  requests  for  customer support through numerous channels. Our service group
also  provides  training  and  educational  programs  to  researchers  using our
products.


Channeling and Distribution Alliances.


     Content  Channeling  Relationships.  We  have  entered  into  and intend to
continue  to seek distribution or reselling agreements with various biomolecular
data  content  providers to sell subscriptions to their data sets to our GenoMax
and  Vector  NTI  Suite  customers. These alliances leverage our market presence
and  use  our  software as an integration and analysis tool for the data content
of our partners.


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<PAGE>

Through  such  arrangements,  we  seek  to share in ongoing subscription content
revenues  and  receive  a  portion of milestone payments and royalties resulting
from  end-user  discoveries  derived from this content. To date, we have entered
into alliances with the following organizations:

   o AxCell  Biosciences  Corporation.  In  August  1999,  we  entered  into  an
     agreement  with  AxCell  Biosciences,  a wholly owned subsidiary of Cytogen
     Corporation,  to  market  AxCell's  proprietary protein-protein interaction
     database  with  our  GenoMax  enterprise product. AxCell is a leader in the
     production  of  protein-protein  interaction data. Under this agreement, we
     will  develop  and  market, on a subscription basis, a product that couples
     AxCell's   proprietary   protein  databases  with  our  GenoMax  enterprise
     platform.  Under  this agreement, we will receive a portion of subscription
     revenues,  and milestone payments and royalties associated with discoveries
     based on data delivered via our content platform.

   o Centre  National  de  la  Recherche  Scientifique (CNRS). In March 2000, we
     entered  into  a letter of intent with CNRS, the French National Center for
     Scientific   Research,   to   market  CNRS's  databases  with  our  GenoMax
     enterprise  product.  CNRS  maintains proprietary databases containing data
     on  gene  structure, expression, and location within the human genome. This
     product  would be marketed on a subscription basis and we would be entitled
     to  receive  a portion of the net revenue from sales to our customers and a
     portion  of any milestone payments and royalties. The letter of intent also
     provides  for  us  to  work  with  CNRS  to  establish a European Center of
     Excellence  in  Computational  Genomics  and  Proteomics  to  be located in
     Villejuif, France.

   o Structural  Bioinformatics.  In  August  2000, we entered into an agreement
     with    Structural    Bioinformatics,    to    market   their   proprietary
     three-dimensional  protein  structure  database with our GenoMax enterprise
     product.  Structural  Bioinformatics  is  a  leader  in  the  production of
     three-dimensional  protein  structure  data.  Under this agreement, we will
     develop  and  market,  on  a  subscription  basis,  a  product that couples
     Structural  Bioinformatics'  three-dimensional  protein structure databases
     with  our  GenoMax  enterprise platform. As resellers of this data, we will
     receive a portion of subscription revenues.

     Hardware  Reselling  Alliance.  We believe that we can further leverage our
market  presence and increase our product offerings to our customers by entering
into  distribution and reselling agreements with selected bioinformatic hardware
companies.   In   March  2000,  we  entered  into  an  alliance  with  TimeLogic
Corporation  to  link  its  DeCypher  genomic analysis accelerator products that
speed  data  mining,  with  our  GenoMax  enterprise  platform. Pursuant to this
agreement,  we  will  market  DeCypher  to  our customers along with our GenoMax
product and share in a portion of net revenues and maintenance fees.

     e-Commerce  Opportunities.  Researchers  use our Vector NTI Suite to design
and  simulate laboratory experiments. Vector NTI Suite provides researchers with
specific  experimental  protocols and recommendations for reagents, enzymes, and
other   specific   genomic  material  necessary  to  execute  actual  laboratory
experiments.  To  extend  this  functionality, we intend to incorporate Internet
hyperlinks  into  our  Vector  NTI  Suite  product  to  enable users to purchase
genomic  products and materials relevant to their research directly from online,
partnered   reagent  vendors.  We  expect  to  generate  transaction  fees  from
partnered  vendors  for  providing  them access to our user base at the point of
their research decisions.

     In  September  2000,  we  entered  into  an agreement with Incyte Genomics,
Inc.,  a  manufacturer and provider of genomic and other biomolecular databases.
Under  our  agreement  we will incorporate hyperlinks into Vector NTI Suite that
will  direct  researchers  to Incyte's website. These hyperlinks are intended to
allow  researchers  to register with Incyte and to purchase access to certain of
its  genomic  databases  which  can  be  used  with  the  searching and analysis
functions   of   our  Vector  NTI  Suite.  These  hyperlinks  will  also  enable
researchers  to  purchase  reagents  from  Incyte for their laboratory research.
Under  this  agreement, we will receive a portion of the net revenues associated
with  sales  of  Incyte's  database  and reagent products and a fee based on the
number  of  registrations  with Incyte, each as generated through the hyperlinks
to be contained in Vector NTI Suite.


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<PAGE>

CUSTOMERS

     We  license our desktop software solutions to pharmaceutical, biotechnology
and  agricultural  biotechnology  companies,  academic  and  government research
institutions,  and  individual  researchers. We have sold over 9,000 licenses to
our  Vector  NTI  Suite,  with  more  than 20,000 estimated users, to over 1,300
organizations,   including   over   500   pharmaceutical,   biotechnology   and
agricultural  biotechnology  companies  and 800 academic and government research
institutions.  Since  its  introduction  in  late 1998, we have made 20 sales of
GenoMax. Our major customers include:




<TABLE>
<S>                                <C>                                                 <C>
Pharmaceutical and Agricultural Biotechnology Companies
o AstraZeneca UK Limited           o E.I. du Pont de Nemours and Company               o Pioneer Hi-Bred International, Inc.
o Aventis Pharmaceuticals, Inc.    o Hoechst Marion Roussel                            o Procter & Gamble
o BASF AG                          o Johnson & Johnson                                 o Eli Lilly and Company
o Bristol-Myers Squibb Company     o Merck & Company, Inc.                             o Novartis Agribusiness
                                   o Pfizer, Inc.                                      Biotechnology Research, Inc.
Biotechnology Companies
o Amgen Inc.                       o Biofrontera Pharmaceuticals GmbH                  o Genzyme Corporation
o Aurora Biosciences Corporation   o Diversa Corporation                               o Microbia Incorporated

Academic and Government Research Institutions
o Katholieke Universiteit Leuven   o National Institutes of Health                     o University of Pennsylvania
o European Molecular Biology       o The Whitehead Institute for Biomedical Research   o Washington University in St. Louis
 Laboratory (EMBL)                 o Massachusetts Institute of Technology             o University of Tokyo
</TABLE>

MARKETING AND SALES

     Our  marketing and sales force consists of 54 employees. Our marketing team
uses  a variety of strategies to increase brand recognition for our products and
reach  a  broader  base  of  potential  customers for our bioinformatic software
solutions.  In  addition, the efforts of our service and implementation group to
educate,  convert,  and train researchers on our enterprise and desktop products
support our marketing efforts.

     Our  sales  force is divided into territorial revenue teams. Each territory
is  headed  by  an experienced regional sales vice president and includes a team
dedicated   to   direct  sales  efforts  for  our  GenoMax  enterprise  software
solutions.  GenoMax  enterprise  sales  involve  a significantly longer and more
complex  sales  cycle than our desktop applications, often involving many levels
of procurement and purchasing decisions by a customer organization.

     Each  territorial  revenue  team also includes a tele-sales team focused on
sales  of  our  Vector  NTI Suite of desktop applications. Historical experience
shows  the  typical  sales  cycle  to  be  30  to  60 days from an indication of
interest  to  a  purchase  order.  In  addition,  Vector NTI Suite consists of a
number  of  component  modules,  which allows us to market to new users at a low
initial  price  and  sell  additional  modules  later.  We  also  offer flexible
licensing  alternatives  that  allow  us  to  price consistently across customer
organizations of different sizes.


CO-MARKETING ALLIANCES

     In  connection  with  our sales and marketing efforts, we seek to establish
strategic   alliances   and  co-marketing  relationships  to  accelerate  market
penetration  of  our  bioinformatic  software.  We  believe  that  purchasers of
bioinformatic  software  often look to market leaders in technology to keep them
abreast  of possible emerging industry standards. We also believe that customers
often  select technology leaders because of a perception that there is a reduced
risk  in  making a technology commitment. We have established relationships with
the following leaders in the technology industry:

   o Compaq.  We  jointly  market  our  software products with Compaq technology
     and  benefit  from  a financing arrangement in which Compaq leases computer
     hardware  that is coupled together with our software to its customers. This
     turnkey   approach   reduces   financial   barriers,  and  streamlines  the
     installation  of  our  enterprise software solutions by pre-loading it onto
     Compaq


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<PAGE>

     servers.  Compaq also has agreed to feature our GenoMax enterprise software
     in  its  Center  for  Excellence  in  Bioinformatics, one of its technology
     demonstration  sites  targeted to the biotechnology industry. In June 2000,
     we  jointly  conducted  a  nine-city seminar series with Compaq on enhanced
     biological data mining and integrated genomic analysis.

   o Oracle.  We  jointly market our software products with Oracle databases and
     cooperate  in  the  re-selling  of  Oracle database technology. We are also
     working  with  Oracle  to  streamline  the  installation  of our enterprise
     software  solutions and maximize the functionality and cooperative features
     of our technologies.

   o Sun  Microsystems.  We  jointly  market our software products in connection
     with  the  sale  of  Sun Microsystems servers to industry participants. Sun
     also  has  agreed  to install our GenoMax enterprise platform in one of its
     key technology demonstration sites.

     Web-based  Provision  of  Bioinformatic  Software  Applications. In January
2000,  we  entered  into  an  alliance  with  an  application  service  provider
specializing   in   Internet-hosted   research  informatics  solutions  for  the
biopharmaceutical  market,  to  offer  our GenoMax and Vector NTI Suite software
solutions  as  Web-based,  hosted  applications. We expect that by providing our
software  through an application service provider, we will be able to accelerate
the  deployment and facilitate the management of our software solutions. We made
our  bioinformatic  software  solutions  available  through this Internet-hosted
method in the third quarter of 2000.

STRATEGIC COLLABORATION WITH AMERSHAM PHARMACIA BIOTECH

     In  August  2000,  we  entered  into a strategic relationship with Amersham
Pharmacia  Biotech  under  which  we will jointly develop and market an expanded
version  of  GenoMax  to  provide  an  enterprise-wide  data analysis system for
pharmaceutical  and  biotechnology  companies for integrating and analyzing data
from  genomics,  proteomics  and  drug  screening  production  laboratories. The
primary  use  of  the  data  analysis  system  is  to  enable pharmaceutical and
biotechnology  companies  to accelerate and lower the cost of development of new
drugs  and  therapies.  Under  the  agreement establishing this relationship, we
will  jointly  own,  with  Amersham,  the  jointly  developed  code for the data
analysis  system  and  all  related  intellectual property rights. In connection
with  this  relationship, we have granted a license to Amersham for its internal
use  of  our  GenoMax  software,  as  part  of  the  data  analysis  system. The
relationship has a 20-year term.

     Under  the  agreement,  we will receive a portion of the revenues resulting
from   the   sale,   license   or   maintenance   fees   associated   with   the
jointly-developed  data  analysis system. We will receive 60% of the license and
maintenance  fees  for  every  license  of  the  data  analysis system to a life
science  or  biotechnology  company whose principal place of business is outside
of  the  United  States,  Canada  and  Western Europe, or any such company whose
principal  place  of  business is in the United States, Canada or Western Europe
and  had revenues among the top fifty life science and biotech companies for the
last  calendar  year  (the  "Life  Sciences Market"). We will receive 80% of the
license  and maintenance fees for every license of the data analysis system to a
life  science  or  biotechnology company whose principal place of business is in
the  United  States,  Canada and Western Europe that did not have revenues among
the  top  fifty  life  science  and biotech companies for the last calendar year
(the  "Biotech  Market"). In the event that, in connection with the marketing of
the  jointly  developed  data analysis system, a customer elects to purchase our
software  on  a standalone basis and not as part of the data analysis system, we
will  pay Amersham a one-time fee equal to 10% or 15% of the license fee for our
software  depending  upon  whether  the customer is in the Biotech Market or the
Life  Sciences  Market.  We  will  recognize  revenues  from  the  sale  of  our
standalone  products  that  result  from  joint  marketing  of the data analysis
system  on  a  gross  basis  equal  to  the license fee of our software and will
record  the  one-time  fee  equal  to 10% or 15% of the license fee as a cost of
sale.  Amersham  will  also pay us a portion of any recurring annual maintenance
fees for the relevant markets above equal to the percentages described above.

     The  agreement  prohibits  either party from contacting a customer that was
initially  approached  to  market  the  data  analysis system for the purpose of
selling  one  of  its  standalone products or services, until the earlier of the
date  such  customer  states  that  it  is  not interested in licensing the data
analysis  system  or a date six months from the initial presentation of the data
analysis system to such customer.


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<PAGE>

     We  have  agreed to use commercially reasonable efforts to develop the data
analysis  system  in  accordance with mutually agreed upon specifications. If we
do  not use commercially reasonable efforts to develop the data analysis system,
Amersham  can  terminate  the  agreement.  The  agreement can also be terminated
prior  to the end of the term by mutual agreement of the parties or by one party
upon a breach by the other party.

     We  are required to provide certain training and customer support functions
in connection with the jointly developed data analysis system.

     In  connection with this strategic relationship, Amersham purchased 950,747
shares  of  our  Series  B preferred stock, which are convertible into 1,587,747
shares of common stock, for aggregate proceeds to us of $10 million in cash.


RESEARCH AND DEVELOPMENT

     Recruiting  and  retaining  skilled  personnel for our research and product
development  group is a critical component of our current and future competitive
success.  As  of  September 27, 2000, we had 95 employees dedicated primarily to
research  and product development. Our research and development team consists of
applications    and    systems   programmers,   database   administrators,   and
bioinformatics  designers,  numerous  of  which have experience in both computer
science  and molecular biology. To date, we have not encountered any significant
turnover  in our research and product development group, and we believe that our
products  and  services  have  benefited  from  this  level  of  continuity. Our
research  and  development  expenditures  in  1997,  1998,  and  1999  were $0.4
million,  $1.2  million,  and $2.6 million, respectively, and approximately $2.5
million for the first six months of 2000.

     Our  research  and product development group possesses core competencies in
C/C++,  Java,  MS  Windows, Apple OS, UNIX, object-oriented design, system-level
programming,  relational  database  design  and  development,  including Oracle,
graphical  user  interface  programming,  bioinformatics, and molecular biology.
Our  team  has  a  significant level of aptitude in working with a wide array of
biomolecular  data,  including  DNA  and  protein sequences and structures, gene
expression,  genetic maps, protein-protein interaction, and SNPs. We continue to
enhance  our  existing  products  in an effort to expand their functionality and
utility.  Our  research  and  product  development  team  seeks  to  develop new
products  that  use  computational  methods  to  further  understand  biological
processes   and   enable  users  of  genomic  data  to  realize  efficiency  and
productivity gains.


COMPETITION

     We   believe  that  the  principal  competitive  factors  in  the  evolving
bioinformatic software industry include:

     o functionality and ease of use of software products;

     o rapid incorporation of technological and biomolecular innovations;

     o product flexibility, scalability, and integration;

     o level   of   customer   service,   product  implementation,  and  support
functions;

     o existing market penetration and brand awareness;

     o alliances with strategic partners and technology market leaders; and

     o price.

     We  face,  or  expect  to  face,  competition  for  market  leadership from
industry participants, including:

     o third party commercial software vendors;

     o bioinformatic developers;

     o internal   bioinformatics  departments  of  some  of  our  customers  and
potential customers;

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<PAGE>

     o organizations    engaging    in   the   provision   of   Internet-hosted,
bioinformatic software; and

     o companies  facilitating Internet-based e-commerce between participants in
our industry.

     We  believe  that  we  compete most often with LION biosciences, NetGenics,
Compugen,  Genomica, DNA Star, Rosetta Inpharmatics, DoubleTwist and GCG, a unit
of  Pharmacopeia  recently  acquired from Oxford Molecular. We intend to compete
with  such  organizations  on  the  basis  of  pricing,  scope  of  products and
services,   functionality   of   products,   quality  of  service,  strength  of
organization and support and training.

     We  believe  that  in response to existing and future market opportunities,
there  is  a  strong  likelihood  of additional market participants. Many of our
current  and  potential  competitors  have  longer operating histories, stronger
name  recognition, and significantly greater financial, technical, and marketing
resources  than we do. As a result of these advantages, these competitors may be
better  able  to adopt more aggressive pricing policies and better positioned to
respond to changes in customer preference or technology.


INTELLECTUAL PROPERTY

     We  believe  that  the proprietary protection of our bioinformatic software
products  is  critical to the success of our business and our ability to compete
effectively.  We  rely upon a combination of trade secret, patent, copyright and
trademark   laws,   license  agreements,  nondisclosure  and  other  contractual
provisions  to  protect  our proprietary rights in our products, technology, and
processes.  In  January  2000,  Dr. Vadim Babenko, our Chief Technology Officer,
assigned  to us an application for a United States patent directed to InforMax's
approach   to  integrated  access  to  biomedical  resources.  Dr.  Babenko  has
previously  assigned  to  us  two copyrights relating to our Vector NTI Suite of
desktop  applications. To date, we have been issued U.S. trademark registrations
for  the marks InforMax and Double Helix Design, Vector NTI, AlignX and BioPlot.
We  have  filed  trademark  applications  in  the  U.S.  for  the marks GenoMax,
InforMax,  the  InforMax  Double  Helix  Logo Design, HTR, HTR Partners Program,
SSBM,   ContigExpress,  High-Throughput  Research,  and  Software  Solution  for
Bio-Medicine,  among  others.  In addition, we have filed trademark applications
in  the  European  Community  Trademark  Office  ("CTM")  for  the marks AlignX,
BioPlot,  Vector  NTI  Suite,  ContigExpress, Software Solution for Bio-Medicine
(SSBM).  We  have  pledged our trademarks to PNC Bank, National Association as a
security for the facilities under our loan agreement.

     Two  oppositions to our CTM trademark application for Vector NTI Suite have
been  filed.  We  have  negotiated a settlement of one opposition and are in the
process  of  negotiations  to  settle  the  other opposition. We believe that an
amicable settlement can be reached.

     Additional  trademark  registrations  in  France  for  the  marks  Align.X,
Vector.NTI,  and  Software  Solution  For Bio-Medicine, among others, are in the
process of being assigned to us by our wholly-owned French subsidiary.

     We  believe  that the source code for our proprietary software solutions is
protected  under applicable copyright and trade secret law in the United States.
Comparable  and  effective  copyright  and  trade  secret  protection may not be
available in each country where we distribute our products.

     We  regularly  enter  into  confidentiality  agreements with our employees,
consultants,  and strategic partners and generally seek to control access to and
distribution  of our software, documentation, and other proprietary information.
We  may  nonetheless  be  subject  to  unauthorized  access  to, and use of, our
software  products. In addition, third parties may be able to develop technology
substantially  similar  to  our  existing  and  future software solutions. These
events  could materially affect our business, financial condition and results of
operations.


EMPLOYEES

     As  of  September  27,  2000,  we had 205 full-time employees, including 95
employees  primarily  engaged  in  research and product development, 54 in sales
and  marketing  and 25 in implementation and support. We believe that our future
success will depend in part on our continued ability to attract


                                       53
<PAGE>

and  retain qualified personnel. Competition for these personnel is intense, and
there  can be no assurance that we will be successful in attracting or retaining
these  personnel  in  the future. None of our employees is currently represented
under  a  collective  bargaining  agreement,  and we consider relations with our
employees to be good.


FACILITIES

     We  lease  approximately 24,400 square feet of office space for our current
headquarters  in  Rockville,  Maryland  for  approximately  $620,000  per  year,
subject  to  an  annual  three  percent  rent escalation. The term of this lease
expires  in  July  2006.  In  September  2000,  we  entered  into a sublease for
approximately  36,190  square  feet  of office space for our new headquarters in
Bethesda,  Maryland.  The  rent  for  this space is approximately $1,357,125 per
year,  subject  to an annual two and one half percent rent escalation during the
term.  The  term  of  this  sublease  expires  on  October 31, 2012. We maintain
additional  offices  in  Annapolis,  San Francisco, Denver, and Oxford, England,
and have sales representatives in Boston and Bonn, Germany.


LEGAL PROCEEDINGS

     We are not currently a party to any material legal proceedings.

                                       54
<PAGE>

                                  MANAGEMENT
DIRECTORS AND EXECUTIVE OFFICERS

     Our  executive  officers, key employees and directors, and their ages as of
the date of this prospectus, are as follows:



<TABLE>
<CAPTION>
NAME                             AGE  POSITION
------------------------------- ----- -----------------------------------------------------
<S>                             <C>   <C>
Alex Titomirov, Ph.D ..........  40   Chairman of the Board of Directors, President and
                                      Chief Executive Officer
James Bernstein, M.D ..........  61   Director, Chief Operating Officer and Executive Vice
                                      President, Strategic Development
Vadim Babenko, Ph.D ...........  38   Chief Technology Officer and Senior Vice President,
                                      Research and Product Development
Joseph Lehnen .................  40   Chief Financial Officer
Timothy Sullivan ..............  40   Senior Vice President, Marketing and Sales
Richard Melzer ................  44   Vice President, Global Sales
Dean Goddette, Ph.D ...........  42   Vice President, Marketing
Peter Covitz, Ph.D ............  35   Director of Implementation and Support Services
Hooks Johnston ................  38   Director
Harry D'Andrea ................  44   Director
Andrew Whiteley ...............  42   Director
Wei Wu He, Ph.D ...............  35   Director
</TABLE>

----------
     Alex  Titomirov,  Ph.D.,  is  the founder of InforMax and has served as our
President,  Chief Executive Officer and Chairman of the Board of Directors since
our  inception  in  1990.  Dr.  Titomirov  is  also the Chairman of the Board of
Directors  of  RealTimeHealth.com,  Inc., a development stage company monitoring
genetic  profiles  over  the Internet. Prior to founding InforMax, Dr. Titomirov
participated   in  research  on  the  developmentally  regulated  expression  of
mammalian  cells  for  gene  targeting  at the Laboratory of Mammalian Genes and
Development  at  the  National  Institutes  of  Health.  Upon his arrival in the
United  States  in  1989,  Dr.  Titomirov  served as a visiting scientist at the
Department  of  Microbiology  at Columbia University. While in the former Soviet
Union,  Dr.  Titomirov served as Group Leader of a research team in the field of
DNA  transfer  technology  at  the Institute of Molecular Biology in Moscow, and
served  as  Head  of  Theoretical  Seminars  at  the  Laboratory  of  Functional
Morphology  of  Chromosomes.  Dr.  Titomirov  has also served as a member of the
Grant  Committee  of  the  Russian  Academy of Sciences and an instructor at the
Moscow   Physical  Technical  Institute.  Dr.  Titomirov  earned  his  Ph.D.  in
Molecular  Genetics  in  1986 from the Institute of Cytology, Russian Academy of
Sciences  in  St. Petersburg, Russia, and his M.S. in Molecular Genetics in 1982
from St. Petersburg State University.

     James  Bernstein, M.D., has served as a director since our inception and as
our   Chief   Operating  Officer  and  Executive  Vice  President  of  Strategic
Development  since  1998.  Dr.  Bernstein is a founder and director of Age Wave,
L.L.C.,  a  holding company that develops businesses driven by population aging,
and  Chairman  of  Age  Wave  Impact,  Inc.,  a  relationship  marketing company
focusing  on  the  50+  population. From 1995 to 1997, Dr. Bernstein served as a
consultant  at  Age Wave, L.L.C. From 1989 to 1994, Dr. Bernstein was engaged in
the  development  of  a  private company for the distribution of pharmaceuticals
and  over-the-counter  medicines  in the former Soviet Union. Dr. Bernstein is a
founder  and  former  Chief  Executive  Officer  of  General  Health,  Inc.,  an
information  publishing  company  in  the  field  of  health risk assessment and
management.  Dr.  Bernstein  has  served as a special consultant to the National
Heart,  Lung  and  Blood  Institute  of the National Institutes of Health with a
focus  on  disease  prevention,  control  and  physician education. Prior to his
tenure  at  NIH,  he  was  a Deputy Director of the Georgetown University Health
Policy  Center.  From  1972  to  1974,  Dr.  Bernstein  headed the office of the
Chairman  of  the Board of Supervisors of San Diego County, California. Prior to
his  government service, Dr. Bernstein was a research associate and Assistant to
the  President  of  the  Salk Institute. Dr. Bernstein received his M.D. in 1964
from  Cornell  University Medical College and his Bachelor's degree in 1960 from
Harvard University.

     Vadim  Babenko,  Ph.D.,  has  served  as  our  Chief Technology Officer and
Senior  Vice  President  of Research and Product Development since our inception
in 1990. Dr. Babenko directs our research and


                                       55
<PAGE>

product  development  team,  having  designed  our  first  product  offering and
directed  all subsequent enhancements. Before arriving in the United States from
the  former  Soviet  Union,  Dr.  Babenko  was  the  Development  Team Leader at
GenInform,  Inc.,  Moscow, where he designed and managed development of software
for  genetic  engineering simulation. Prior to this, he served for five years as
a  Senior Scientist at the Institute of Molecular Genetics at the Soviet Academy
of  Sciences  conducting  research  on  genetic  data  analysis, protein and DNA
modeling,  and  computer  simulation  of  biological  processes using artificial
intelligence  techniques.  Dr.  Babenko has managed a number of research groups,
led  several  international collaborations, and authored over 30 publications in
the  fields of bioinformatics and artificial intelligence. Dr. Babenko also held
an  appointment  as  a  Senior Scientist at the Institute of Informatic Problems
where  he developed original methods for applying systems to medical diagnostics
and  decision  making.  Dr.  Babenko  earned  a  Ph.D.  in biophysics in 1990, a
Master's  degree  in  Theoretical  Physics  in  1985, and a Bachelor's degree in
Automatics  and  Telemechanics  in  1983,  each  from  the  Moscow  Institute of
Physical  Technology.  He  was  cited Outstanding Young Scientist in 1989 at the
Soviet  Academy  of  Sciences,  Outstanding  Researcher  in  1987  by the Soviet
Association  of  Artificial Intelligence, and Best Student Researcher in 1984 by
the Moscow Institute of Physical Technology.

     Joseph  Lehnen  has  served  as  our  Chief Financial Officer since January
1999.  Prior  to joining InforMax, Mr. Lehnen spent eight years as an investment
banker  with  J.P. Morgan & Co., working with health care sector clients ranging
from  early-stage  companies  to  Fortune 100 corporations. His experience as an
investment  banker  included  financing  transactions  in the public and private
markets,   merger   and  acquisition  execution,  industry  analysis,  strategic
advisory  work  and financial risk analysis. Prior to his tenure at J.P. Morgan,
Mr.  Lehnen  held  positions as an aide in the U.S. Senate and as a radar design
engineer  for  Litton  Industries'  defense  contracting  division.  Mr.  Lehnen
received  a  Master's degree in public policy from Harvard University in 1989, a
Master's  degree in physics from Yale University in 1985 and a Bachelor's degree
in physics from Santa Clara University in 1982.

     Timothy  Sullivan  has  served  as our Senior Vice President of Marketing &
Sales  since  January  1999.  Prior  to  joining  InforMax,  Mr.  Sullivan  held
positions  in  product  management,  alliance  management,  and  major  accounts
management  at  Manugistics,  Inc.,  a  supply-chain  decision  support software
vendor,  from  1995  to  1999.  Prior to his tenure at Manugistics, Mr. Sullivan
served  as product manager at TSI Software International, an electronic commerce
vendor,  from  1993  to  1995.  Mr.  Sullivan  previously served as a management
consultant  with  Andersen  Consulting  and  Booz-Allen  &  Hamilton.  Prior  to
entering  the  private  sector  in 1988, Mr. Sullivan was a Platoon Commander in
the  United  States Marine Corps. He received an M.B.A. in Marketing in 1992 and
a Bachelor's degree in Classics in 1984, each from Columbia University.

     Richard  Melzer  has  served  as  our  Vice President of Global Sales since
January  2000.  Mr.  Melzer  previously served as our enterprise account manager
from  April  1999 to December 1999. Prior to joining InforMax, Mr. Melzer served
as  a  senior  account  manager  for  Manugistics, Inc., a supply-chain decision
support  vendor,  from  April 1994 to March 1999. From April 1984 to March 1994,
Mr.  Melzer  served  in  a  number  of  positions  including  Vice President and
Managing  Director  of  European, Middle Eastern and African operations and Vice
President  of  Sales  and  Operations  for DISC, Inc., a NYNEX Company that sold
application  software  to major banks, corporations and insurance companies. Mr.
Melzer  received Bachelor's degrees in International Relations and Multinational
Enterprise from the Wharton School of the University of Pennsylvania in 1978.

     Dean  Goddette,  Ph.D., has served as our Vice President of Marketing since
June  2000.  Prior  to  joining  InforMax, Dr. Goddette held positions including
Vice  President of Marketing and Sales and Vice President of Bioinformatics with
Structural  Bioinformatics,  Inc.  from  August 1998 to June 2000. From December
1993  to  August  1998, Dr. Goddette held positions including Manager of central
U.S.   and  Canada  sales  and  Senior  Product  Manager  for  Tripos,  Inc.,  a
pharmaceutical  and  biotechnology  software  and services company. Dr. Goddette
received  a  Ph.D. in Biochemistry from Washington University School of Medicine
in  1996  and  a  Bachelor's degree in Protein Biophysics from the University of
Connecticut in 1980.

     Peter  Covitz,  Ph.D,  has  served  as  our  Director of Implementation and
Support  Services  since  September  1999.  Dr.  Covitz coordinates our software
integration,  customization, maintenance, support and training efforts. Prior to
joining InforMax, Dr. Covitz led the microarray gene expression


                                       56
<PAGE>

software   team  at  Molecular  Applications  Group,  a  bioinformatic  software
company,  from  September  1998  to August 1999. From March 1997 to August 1998,
Dr.  Covitz  served  as  a  senior product scientist for Incyte Pharmaceuticals,
Inc.  where  he worked with the development of a classification system for their
sequence  databases.  Dr.  Covitz received a Ph.D. in Microbiology from Columbia
University  in  1993  and a Bachelor's degree in Biology from Colgate University
in 1986.

     Hooks  Johnston  has served as a director since June 1999. Mr. Johnston has
been  Managing  Director  of  FBR Technology Venture Partners, a venture capital
investment  firm,  since December 1998. From November 1997 to December 1998, Mr.
Johnston  served  as  the President of Descartes Systems Group, a leading supply
chain  software  company, which he assisted in taking public in early 1998. From
September  1995 to November 1997, Mr. Johnston served as the President and Chief
Executive  Officer  of  Roadshow  International, Inc., a transportation software
company  that was acquired by Descartes. From August 1993 to September 1995, Mr.
Johnston  was  the Chief Operating Officer of ALG, Inc., a design, pre-press and
web  development  services  company. Mr. Johnston currently serves on the boards
of  directors  of  Intranets.com,  Inc.,  MarketSwitch  Corporation, B2Emarkets,
Inc.,  Shop2u,  Inc.,  Radiowave.com,  Inc.,  Collaborex, Inc., Global Logistics
Technologies,  Inc.  and  Shelflink,  Inc.  Mr. Johnston received an M.B.A. from
Harvard  Business  School  in  1988, and a Bachelor of Science degree in Applied
Mathematics and Economics from Brown University in 1984.

     Harry  D'Andrea  has served as a director since June 1999. Mr. D'Andrea has
been  the  Chief Financial Officer of Advanced Switching Communications, Inc., a
telecommunications  equipment  provider,  since  June  1999. From August 1998 to
June  1999, Mr. D'Andrea served as Chief Financial Officer of Call Technologies,
inc.,  a  telecommunications software provider. From June 1997 to July 1998, Mr.
D'Andrea  served  as  Chief Financial Officer of Yurie Systems, Inc., a provider
of  networking and telecommunications equipment. In 1996, Mr. D'Andrea served as
Chief  Financial  Officer of American Communications Services, Inc., now e.spire
Communications,  Inc.,  a telecommunications service provider. Prior to that Mr.
D'Andrea  served  as  Executive  Vice  President,  Chief  Financial  Officer and
Treasurer   of  Caterair  International  Corporation,  a  provider  of  catering
services  for commercial airlines. Mr. D'Andrea currently serves on the board of
directors  of  Coagulation  Diagnostics, Inc. Mr. D'Andrea received an M.B.A. in
Finance  from  Drexel  University  in  1980  and  a Bachelor's degree in Foreign
Service from Pennsylvania State University in 1978.

     Andrew  Whiteley  has  served as a director since August 2000. Mr. Whiteley
has  been  the  Vice President of Bioinformatics for Amersham Pharmacia Biotech,
Inc.,  a  provider  of  integrated drug discovery solutions, since January 2000.
From  October  1997  to  December 1999, Mr. Whiteley served as Vice President of
Amersham  Pharmacia  Biotech's  sequencing business. For a portion of the period
above,  Mr.  Whiteley  also  served  as site director for Amersham International
PLC's  Cleveland  facility.  From April 1995 to March 1997, Mr. Whiteley was the
head  of  Amersham  International's  group marketing. Mr. Whiteley serves on the
board  of  directors  of  Cimarron Software Services, Inc. and Imaging Research,
Inc.  Mr.  Whiteley  received  Bachelor's  degrees in Chemistry and BioChemistry
from Nottingham University in the U.K. in 1980.

     Wei-Wu  He,  Ph.D., has served as a director since August 2000. Since March
2000,  Dr. He has served as the General Partner of Emerging Technology Partners,
L.L.C.,  a  venture  capital  fund  he founded that is dedicated to investing in
genomics  technology  companies.  In  1996,  Dr. He founded OriGene Technologies
Inc.,  a  provider  of genomics technologies for the pharmaceutical industry and
served  as  President from June 1996 to March 2000. From 1993 to 1996 Dr. He was
a  scientist  at Human Genome Sciences, Inc. and prior to that he was a research
fellow  at  Massachusetts  General  Hospital. Additionally, Dr. He serves on the
Board  of Directors of numerous organizations such as the Chinese Pharmaceutical
Association,  of which he was elected President in 2000, the Scientific Advisory
Board  of F & S Inc., the Monte Jade Association, and Aptus Genomics Inc. Dr. He
received  his  Ph.D. in Molecular Biology from the Baylor College of Medicine in
1991  and  a  Bachelor's degree in Biochemistry from Nanjing University in 1985.
Dr.  He  also  received  an  M.B.A. from The Wharton School of the University of
Pennsylvania in 1999.


                                       57
<PAGE>

BOARD STRUCTURE

     Our  bylaws  currently  provide  for a board of directors consisting of not
more  than  seven  members,  to  be  fixed  from  time  to  time by our board of
directors.  All  directors  hold  office  until  the  next annual meeting of our
stockholders  and  until  their  successors  have  been elected and qualified or
until  their  earlier  resignation  or  removal.  Messrs. Johnston, D'Andrea and
Whiteley  were  elected to the board of directors under a voting agreement among
us,  FBR  Technology Venture Partners II, LP, Amersham Pharmacia Biotech and our
other   principal  stockholders.  This  voting  agreement  will  terminate  upon
completion of this offering.

     In  accordance  with  the  terms of our amended and restated certificate of
incorporation  to  be  effective  upon completion of this offering, the board of
directors  will be divided into three classes, each serving staggered three-year
terms, following the completion of this offering:

   o Class  I,  whose initial term will expire at the annual meeting, or special
     meeting held in lieu of an annual meeting, of stockholders held in 2001;

   o Class  II,  whose  initial  term  will  expire  at  the  annual meeting, or
     special  meeting held in lieu of an annual meeting, of stockholders held in
     2002; and

   o Class  III,  whose  initial  term  will  expire  at  the annual meeting, or
     special  meeting held in lieu of an annual meeting, of stockholders held in
     2003.

As  a result, only one class of directors will be elected at each annual meeting
of  stockholders of InforMax with the other classes continuing for the remainder
of  their  respective  terms.  Mr.  D'Andrea  and Dr. He have been designated as
Class  I directors; Mr. Johnston and Dr. Bernstein have been designated as Class
II  directors;  and Dr. Titomirov and Mr. Whiteley have been designated as Class
III  directors.  These  provisions  in  our  amended and restated certificate of
incorporation  may  have the effect of delaying or preventing changes in control
or management of InforMax.


BOARD COMMITTEES

     We  have  two  standing  committees:  a compensation committee and an audit
committee.  The  compensation  committee  currently consists of Messrs. Johnston
and D'Andrea. The compensation committee:

   o reviews  and  approves  the  compensation  and  benefits  for our executive
     officers  and  grants stock options under our equity incentive compensation
     plan; and

     o makes  recommendations to the board of directors regarding these matters.


     The  audit  committee  consists  of Messrs. Johnston, D'Andrea, and He. The
audit committee:

   o makes  recommendations  to  the  board of directors regarding the selection
     of independent auditors;

   o reviews  the  results and scope of the audit and other services provided by
     our independent auditors; and

     o reviews and evaluates our audit and control functions.


COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

     No  executive  officer  of  InforMax  serves  as  a  member of the board of
directors  or  compensation  committee  of  any  entity  that  has  one  or more
executive  officers serving on our board of directors or compensation committee.


                                       58
<PAGE>

COMPENSATION OF DIRECTORS

     Directors  do  not receive cash compensation for their service on our board
of  directors or any board committee. In 1999, we granted Mr. D'Andrea an option
to  purchase  25,050  shares  of our common stock at an exercise price of $0.30.
Such  options  are  subject  to  conditions  relating  to  vesting and continued
participation  on  our  board  of directors. We reimburse non-employee directors
for  their  reasonable  expenses incurred in connection with their attendance at
meetings  of  our  board of directors and board committees and may in the future
issue options to non-employee directors upon:

     o appointment, election, or re-election to the board; and

     o each anniversary thereof if he or she continues to serve as a director.


SCIENTIFIC ADVISORY BOARD

     We  have  recruited  a  scientific advisory board consisting of individuals
with   expertise   in   genomics,  bioinformatics,  information  technology  and
pharmaceutical  discovery.  Our  scientific  advisory board was assembled during
the  second  quarter  of  2000  and we anticipate consulting with our scientific
advisory board regarding industry and scientific developments.

<TABLE>
<CAPTION>
                     NAME                                    POSITION AND ORGANIZATION
--------------------------------------------- ------------------------------------------------------
<S>                                           <C>
Michael N. Liebman, Ph.D, Chairman .......... Global Head, Computational Genetics, Roche
                                              Biosciences

Jacquelyn S. Fetrow, Ph.D ................... Chief Scientific Officer, GeneFormatics, Inc.

Lawrence M. Kauvar, Ph.D .................... President, Trellis Bioinformatics, Inc.

Doron Lancet, Ph.D .......................... Professor of Neurogenomics, Weizmann Institute
                                              Crown Human Genome Center

F. Raymond Salemme, Ph.D .................... President and Chief Scientific Officer, 3-Dimensional
                                              Pharmaceuticals, Inc.

John N. Weinstein, M.D., Ph.D ............... Group Chief of National Cancer Institute, National
                                              Institutes of Health

Arthur L. Williams, Ph.D .................... Executive Director Pharmaceutical Development
                                              Informatics, Bristol-Myers Squibb

George Maalouf, Ph.D ........................ Vice President of Bioinformatics, NeoGenesis Drug
                                              Discovery, Inc.

Charles Auffray, Ph.D ....................... Director of Research, Centre Nationale de la
                                              Recherche Scientifique

Wei Wu He, Ph.D ............................. General Partner, Emerging Technologies, L.L.C.
</TABLE>

KEY MAN INSURANCE

     We  maintain  "key  man" life insurance in the amount of $2,000,000 on each
of Dr. Titomirov and Dr. Babenko, with proceeds payable to us.

EMPLOYMENT AGREEMENTS

     On  August  14,  2000,  Dr.  Alex Titomirov provided us a commitment letter
regarding  his  continued  service  with  us.  Under  the commitment letter, Dr.
Titomirov  agreed  to  devote  to  us  at  least  a majority of his professional
working time for a period equal to the longer of (1) 18 months


                                       59
<PAGE>

from  the  date  of  this  prospectus, provided such date does not extend beyond
August  14,  2003, or (2) August 14, 2002. This commitment is conditioned on his
salary  continuing at a rate not less than his current salary and his receipt of
bonuses  commensurate  with  those  received by our other senior management. Dr.
Titomirov  has  further agreed that for a period of two years after he ceases to
be  an  officer,  employee  or 10% holder of our outstanding shares, he will not
directly  render  services  for any business engaged in such business activities
that  we are involved in at the time of his termination or which are anticipated
and  have  been  approved  by our board of directors by that time. Dr. Titomirov
has  also  agreed  that  for such two year period he will not hire or attempt to
hire  any  of  our employees, or persons that were employed by us during the one
year  period  prior  to  his ceasing to be an officer, employee or 10% holder of
our outstanding shares.

     In  July  2000, we entered into an employment agreement with Vadim Babenko,
to  serve as our Chief Technology Officer through July 14, 2002. The term of Dr.
Babenko's  employment  automatically  renews  for  successive  one  year periods
unless  and  until  either  party provides written notice, not less than 90 days
prior  to  the  end  of  the  then  current  term, of their intent not to renew.
Pursuant  to  this agreement, Dr. Babenko's salary was set at $285,000 per year,
with  eligibility for increases and bonuses as determined by the Chief Executive
Officer  and  our board of directors. In the event that Dr. Babenko's employment
is  terminated  by  us  without  cause, he will receive a lump sum payment of an
amount  equal  his  then  effective annual salary. Dr. Bakenko has agreed not to
compete  with  us  or solicit our employees during the term of our agreement and
for a period of two years following the termination of this agreement.

     In  April 1999, we entered into an employment agreement with Joseph Lehnen,
to  serve  as  our  Chief  Financial  Officer  and Senior Vice President through
December  31, 2002. The term of Mr. Lehnen's employment automatically renews for
successive  one  year  periods  unless  and  until either party provides written
notice,  not  less  than  90  days prior to the end of the then current term, of
their  intent  not  to  renew.  Pursuant to this agreement, Mr. Lehnen's initial
salary  was  set  at  $150,000  per year, with eligibility for bonuses and stock
options  as  determined  by  the  Chief  Executive  Officer  and  our  board  of
directors.  In  the  event  that  Mr.  Lehnen's  employment  is terminated by us
without  cause,  or  terminated  by  Mr. Lehnen as a result of our breach of his
employment  agreement,  he  will receive an amount equal to fifty percent of his
salary  and  bonus  for  the  previous  12  month  period. In the event that Mr.
Lehnen's  employment  is terminated without cause upon, or within one year of, a
change  of control of our company, he will receive an amount equal to his salary
and  bonus  for  the  previous  12 month period. In the event that Mr. Lehnen is
terminated  for  cause  or  voluntarily  resigns  without  breach  by  us of our
agreement,  he  has agreed not to compete with us or solicit our employees for a
period of 12 months following the cessation of his employment.

     In  April  1999,  we  entered  into  an  employment  agreement with Timothy
Sullivan,  to  serve  as our Senior Vice President, Marketing and Sales, through
March  31,  2003. The term of Mr. Sullivan's employment automatically renews for
successive  one  year  periods  unless  and  until either party provides written
notice,  not  less  than  90  days prior to the end of the then current term, of
their  intent  not  to renew. Pursuant to this agreement, Mr. Sullivan's initial
salary  was  set at $150,000 per year plus monthly commissions of one percent of
that  month's  software license and professional services revenues. In the event
that  Mr. Sullivan's employment is terminated by us without cause, or terminated
by  Mr.  Sullivan as a result of our breach of his employment agreement, he will
receive  an  amount  equal to fifty percent of his salary and earned commissions
for  the  previous  12 month period. In the event that Mr. Sullivan's employment
is  terminated without cause upon, or within 180 days of, a change of control of
our  company,  he  will  receive an amount equal to his annual salary and earned
commissions  for the previous 12 month period. In the event that Mr. Sullivan is
terminated  without  cause, other than upon a change of control, or Mr. Sullivan
terminates  his  employment  as  a  result  of  our  breach  of  his  employment
agreement,  he  has agreed not to compete with us or solicit our employees for a
period  of  six  months  following the cessation of his employment. In the event
that  Mr.  Sullivan's  employment  is  terminated  for  any other reason, he has
agreed  not  to  compete  with  us  or  solicit our employees for a period of 12
months following the cessation of his employment.


                                       60
<PAGE>

EXECUTIVE COMPENSATION

     The  following table sets forth compensation awarded to, earned by, or paid
to  our  Chief  Executive  Officer  and  the  four other most highly compensated
executive  officers  whose  total cash compensation exceeded $100,000 during the
year ended December 31, 1999.

                          SUMMARY COMPENSATION TABLE

<TABLE>
<CAPTION>
                                                                               LONG-TERM
                                           ANNUAL COMPENSATION               COMPENSATION
                                 ---------------------------------------   ----------------
                                                                              SECURITIES
                                                                              UNDERLYING
NAME AND PRINCIPAL POSITION       YEAR          SALARY           BONUS          OPTIONS
------------------------------   ------   -----------------   ----------   ----------------
<S>                              <C>      <C>                 <C>          <C>
Dr. Alex Titomirov,              1999        $  300,757          0            6,512,833
 Chief Executive Officer and
   Chairman of the Board of
   Directors
Dr. Vadim Babenko,               1999        $  200,000          0            2,672,000
 Chief Technology Officer and
   Senior Vice President
Dr. James Bernstein,             1999        $  225,000          0            1,753,500
 Chief Operating Officer and
   Executive Vice President
Joseph Lehnen,                   1999        $  145,000(1)    $35,000           584,500(2)
 Chief Financial Officer
Timothy Sullivan,                1999        $  222,747(3)       0              626,250(4)
 Senior Vice President,
   Marketing and Sales
</TABLE>

(1) Under  the  terms of his April 1999 employment agreement Mr. Lehnen's annual
salary is $150,000.
(2) Does not include 167,000 options granted on January 1, 2000.

(3) Includes $72,747 in commissions based on the sale of our software products.

(4) Does not include 292,250 options granted on January 1, 2000.

                                       61
<PAGE>

OPTIONS GRANTS DURING 1999

     All  of the following stock options were granted under our equity incentive
plan  and  are exercisable for shares of our common stock. The percentages below
are  based  on a total of 14,932,487 shares subject to options we granted during
the  year  ended December 31, 1999 to our employees, directors, and consultants,
including the executive officers named in the Summary Compensation Table.

     The  exercise  price  per  share of each option is equal to the fair market
value  of  the  common stock as determined by the board of directors on the date
of  grant.  The  potential  realizable  value  is  based  on  the initial public
offering  price  of  $16.00  per  share.  The calculations below assume that the
price  of our common stock increases from the date of grant until the end of the
ten-year  option  term  at the assumed 5% and 10% rates. These assumed rates are
calculated  based on rules promulgated by the Securities and Exchange Commission
and  do  not reflect future stock price growth. The actual value realized may be
greater or less than the assumed rates illustrated in the table.


                       OPTION GRANTS IN LAST FISCAL YEAR

<TABLE>
<CAPTION>
                          NUMBER OF     PERCENT OF                                      POTENTIAL REALIZABLE
                           SHARES          TOTAL       EXERCISE                           VALUE AT ASSUMED
                         UNDERLYING       OPTIONS        PRICE                          ANNUAL RATES OF STOCK
                           OPTIONS      GRANTED TO        PER       EXPIRATION         PRICE APPRECIATION FOR
                           GRANTED       EMPLOYEES       SHARE         DATE                  OPTION TERM
                        ------------   ------------   ----------   ------------   ---------------------------------
                                                                                         5%               10%
NAME
<S>                     <C>            <C>            <C>          <C>            <C>               <C>
Dr. Alex Titomirov       6,512,833          43.6%       $ .30       3/20/2009      $167,785,649      $268,327,934
Dr. Vadim Babenko        2,672,000          17.9%       $ .30       3/20/2009      $ 68,836,903      $110,086,078
Dr. James Bernstein      1,753,500          11.7%       $ .30       3/20/2009      $ 45,174,218      $ 72,243,988
Joseph Lehnen              584,500           3.9%       $ .30       3/24/2009      $ 15,058,073      $ 24,081,329
Timothy Sullivan           626,250           4.2%       $ .30       3/24/2009      $ 16,133,649      $ 25,801,424
</TABLE>

AGGREGATE OPTION EXERCISES DURING 1999 AND YEAR-END OPTION VALUES

     The  following  table provides summary information concerning the shares of
common  stock  represented  by  outstanding  stock  options  held by each of the
executive  officers  named  in the Summary Compensation Table as of December 31,
1999.

     The  value realized represents the difference between the fair market value
of  the  shares  as  of  December 31, 1999, based on the initial public offering
price of $16.00 per share, and the exercise price of the option.





<TABLE>
<CAPTION>
                             NUMBERS OF SECURITIES
                            UNDERLYING UNEXERCISED          VALUE OF UNEXERCISED IN-THE-
                                  OPTIONS AT                      MONEY OPTIONS AT
                                FISCAL YEAR END                   FISCAL YEAR END
                        -------------------------------   --------------------------------
                         EXERCISABLE     UNEXERCISABLE      EXERCISABLE      UNEXERCISABLE
<S>                     <C>             <C>               <C>               <C>
Dr. Alex Titomirov        6,512,833               0        $102,255,378                0
Dr. Vadim Babenko         3,340,000               0        $ 52,636,000                0
Dr. James Bernstein       1,780,220               0        $ 27,958,360                0
Joseph Lehnen               347,049         237,451(1)     $  5,448,877       $3,728,123
Timothy Sullivan            169,602         456,648(1)     $  2,662,853       $7,169,647
</TABLE>

(1) Subsequent  to  December  31,  1999,  the vesting of the covered options has
    been  accelerated  such  that  all  options  are  currently  exercisable  by
    Messrs. Lehnen and Sullivan.


                                       62
<PAGE>

EQUITY INCENTIVE COMPENSATION PLAN


     Administration

     We  established  our  equity  incentive  compensation  plan, as amended, in
order  to  provide  incentives  for our eligible officers, employees, directors,
and  consultants  to  improve  our  business  results, by giving such persons an
opportunity  to  acquire  or increase their proprietary interest in us. Our plan
also  better  enables  us  to  attract,  retain, and reward talented and skilled
personnel.

     Our  plan  may  be  administered  by  our  board  of  directors  or a board
committee.  Subsequent  to  this  offering, our plan will be administered by the
compensation  committee  of  our board of directors, which will include at least
two  "disinterested persons," for purposes of Rule 16b-3 under the Exchange Act,
and  "outside  directors,"  within the meaning of Section 162(m) of the Internal
Revenue  Code  of  1986. The administrator has authority to take all actions and
make all determinations required or provided for under our plan, including:


     o determination of the terms of any options or other awards granted;


     o the exercise price of the option or other award;


     o the number of shares subject to each option or other award;


     o the exercisability and vesting thereof;


     o and the form of consideration payable upon such exercise.


Moreover,  the administrator may rescind, modify or waive certain limitations or
conditions  associated  with  a  grant  under  the  plan so as to accelerate the
exercise  period.  Currently,  the  total  number  of shares of our common stock
authorized  for  use  by the plan is 8,179,000. As of September 27, 2000, 50,100
shares  of  restricted  stock and 5,054,542 options exercisable for common stock
were  outstanding  pursuant  to incentive awards under the plan. As of September
27,  2000, we also had outstanding 50,100 shares of restricted stock and options
to purchase 8,530,103 shares of common stock.

     Stock Options

     The  plan  provides for the discretionary grant of incentive stock options,
within  the  meaning  of  Section  422 of the Internal Revenue Code, and for the
grant  of non-qualified stock options. The exercise price of all incentive stock
options  granted  under  our  plan  must  be  at least equal to 100% of the fair
market  value  of  the  shares underlying the options on the date of grant. With
respect  to  any  participant  who  owns  stock  possessing more than 10% of the
voting  power  of  all  classes  of  our outstanding capital stock, the exercise
price  of  any  incentive stock option granted must be at least equal to 110% of
the  fair  market  value  on the grant date and the term of such incentive stock
option  must not exceed five years. Under our plan, an option will constitute an
incentive  option only to the extent that the aggregate fair market value of the
underlying  stock,  at  the  time of the option grant, does not exceed $100,000.
The  exercise  price  of any stock options issued under our plan may not be less
than  the  par  value of the underlying common stock. The term of options issued
under our plan may not exceed ten years.

     Restricted Stock

     Under  our  plan,  the administrator may grant to such eligible individuals
shares  of  our  restricted common stock, subject to the recipient's both paying
not  less  than  the  par value of such common stock and attaining or completing
any  performance  objectives  and  service requirements upon which such grant is
conditioned.  Upon  the  recipient's  non-payment of the price specified for the
shares,  failure to attain the performance objectives prior to expiration of the
specified  period,  or  termination  of  employment without having satisfied the
service  requirement, the shares of restricted stock, or the appropriate portion
thereof,  will be forfeited and will again be available for reissuance under the
terms of our plan.


                                       63
<PAGE>

     Transferability

     Options  and  other  awards  granted  under  our  plan  are  generally  not
transferable  by  the recipient. Awards granted under the plan must generally be
exercised  within  six  months  after a recipient's death or permanent and total
disability,  but  in  no  event  later than the expiration of the option's term.
Except  as  may  be  provided  by  the  administrator in the option agreement or
restricted  stock  agreement,  upon  termination of employment or service, other
than  by reason of death or permanent and total disability, shares of restricted
stock  and options that have not become vested under the plan will terminate and
the  recipient thereof will have no further right to purchase the covered shares
of  common  stock. Upon the termination of the recipient's employment or service
for  any reason, we will have the right, for a period of 180 days following such
termination,  to  repurchase  any or all of the shares acquired by the recipient
pursuant  to  an  incentive award under the plan at either the fair market value
of  such  shares on the date of termination, or a lower price as specified in an
agreement at the time of grant.

     Change in Capitalization, Merger or Sale

     The  number  and  price  of shares covered by outstanding stock options and
restricted   stock  awards  granted  under  the  plan  will  be  proportionately
adjusted,  as  determined  by  our  board of directors, to take into account any
recapitalization,   stock   split,   reverse   stock   split,   stock  dividend,
combination,  exchange  or reclassification of shares or similar event. The plan
provides that if we:

   o liquidate,   dissolve,   merge,  consolidate  or  reorganize  with  another
     company in which we are not the surviving entity;

   o sell substantially all of our assets to another company; or

   o approve  a  transaction  that results in any person or entity owning 80% or
     more  of  the voting power of all classes of our stock, other than existing
     stockholders at the time our plan was approved, and their affiliates,

then  all options outstanding under the plan will terminate if the option is not
assumed  by  the  surviving  corporation,  its  parent or subsidiary, or if such
entities  do  not  substitute another award reflecting an appropriate adjustment
to  the number and price of such covered shares. In the event that the option is
terminated  as  a  result of the transactions above, the holder will be given an
opportunity  to  exercise  the vested portion of the option immediately prior to
the option's termination.


                                       64
<PAGE>

                             CERTAIN TRANSACTIONS

SERIES B CONVERTIBLE PREFERRED STOCK FINANCING

     On  August 16, 2000, we sold 950,747 shares of our Series B preferred stock
to  Amersham  Pharmacia  Biotech,  Inc.  in  connection with the creation of our
strategic  relationship. We sold the preferred stock at approximately $10.52 per
share,  for  aggregate  proceeds  to us of $10 million in cash. We expect to use
the   proceeds   for   general  working  capital  purposes.  These  shares  will
automatically   be   converted   into  1,587,747  shares  of  our  common  stock
immediately  prior  to  the closing of this offering, with an aggregate value of
$25,403,952,  based  on  the  initial offering price of $16.00 per share. Andrew
Whiteley,  one  of  our  directors,  is  the Vice President of Bioinformatics of
Amersham Pharmacia Biotech.

     In  connection  with  the  sale of preferred stock, we amended and restated
our  investor rights agreement to grant certain registration rights to Amersham.
In  the  event  that  we are able to effect a short form registration, Amersham,
subject  to  certain  conditions,  may  require  us  to file such a registration
statement.  In  addition, Amersham is entitled to certain piggyback registration
rights  by which it can, subject to certain circumstances, include shares of its
common  stock in a registration statement filed by us. Amersham's short form and
piggyback  registration  rights  terminate  when  all  of its shares can be sold
under  Rule  144  in  any  90  day  period.  The  investor rights agreement also
contains  certain  restrictions  on Amersham's ability to transfer its shares of
our stock.

     In  connection  with  the  sale of our Series B preferred stock, we entered
into  a  20  year  strategic  relationship with Amersham Pharmacia Biotech under
which  we  will  jointly  develop  and  market an expanded version of GenoMax to
provide   an   enterprise-wide  data  analysis  system  for  pharmaceutical  and
biotechnology  companies  for  integrating  and  analyzing  data  from genomics,
proteomics and drug screening production laboratories.

SERIES A CONVERTIBLE PREFERRED STOCK FINANCING

     On  June 22, 1999, we sold 2,161,265 shares of our Series A preferred stock
to  FBR  Technology  Venture  Partners II, LP, at approximately $1.85 per share,
for  aggregate  proceeds to us of $4 million in cash. The proceeds were used for
general  working  capital purposes. These shares will automatically be converted
into  3,609,312  shares  of our common stock immediately prior to the closing of
this  offering,  with  an  aggregate  value of $57,748,992, based on the initial
offering  price  of $16.00 per share. Hooks Johnston, one of our directors, is a
managing  director  of  FBR  Technology Venture Partners, the general partner of
FBR Technology Venture Partners II, LP.

     In  connection  with  the  sale of our Series A preferred stock, we entered
into  an  investor rights agreement with FBR Technology Venture Partners II, LP,
which  was  amended and restated in August 2000, with respect to the granting of
certain  registration  rights. FBR, and each of the other FBR entities disclosed
in  the  "Principal  Stockholders"  as  assignees  of  FBR,  were granted demand
registration  rights  pursuant to which they may, subject to certain conditions,
and  beginning  180  days from the date of this prospectus, require us to file a
registration  statement on their behalf covering shares of their common stock on
not  more  than  two  occasions. These rights expire five years from the date of
this  prospectus.  In  the  event  that  we  are  able  to  effect  a short form
registration,  the  FBR  entities, subject to certain conditions, may require us
to  file such a registration statement on up to four occasions. In addition, the
FBR  entities  are  entitled  to  certain piggyback registration rights by which
they  can,  subject  to  certain  circumstances,  include shares of their common
stock  in a registration statement filed by us. The FBR entities' short form and
piggyback  registration  rights  terminate  when all of their shares can be sold
under  Rule 144 in any 90 day period or if their ownership falls below 1% of our
outstanding shares.

     The  investor  rights  agreement  also contains certain restrictions on the
FBR entities ability to transfer their shares of our common stock.


                                       65
<PAGE>

OTHER RELATED PARTY TRANSACTIONS

     In  1999,  Dr.  Titomirov,  our  President  and  Chief  Executive  Officer,
personally  guaranteed  an  equipment  loan  facility  of  ours in the amount of
$125,000. The outstanding balance was paid in full in 1999.

     In  1999,  Dr.  Titomirov personally guaranteed a line of credit of ours in
the amount of $400,000. The outstanding balance was paid in full in 1999.

     In  April  1999, we loaned $65,000 to Dr. Titomirov. The amount of the loan
was  secured by a promissory note to be repaid upon the fifth anniversary of the
date  of  the  loan.  Interest accrued at the prime rate as reported in The Wall
Street  Journal  plus  1%  and was due and payable on each anniversary until the
balance  of  the  note  was paid in full. The funds were loaned to Dr. Titomirov
for  payment  of  federal and state income taxes. The principal and interest due
thereon associated with this note were fully repaid in July 2000.

     In  June  1999, we granted Mr. D'Andrea, one of our directors, an option to
purchase  25,050  shares  of  our common stock at an exercise price of $0.30 per
share.  Such options are subject to conditions relating to vesting and continued
participation on our board of directors.

     In  March  2000,  Dr.  Titomirov entered into a private transaction for the
sale  of  835,000  shares to FBR Technology Venture Partners II, LP at $5.99 per
share.  In  March  2000,  Dr.  Titomirov  and  Dr. Babenko, our Chief Technology
Officer,  entered  into  a private transaction with certain of the Weiss, Peck &
Greer  entities  disclosed in the "Principal Stockholders" table for the sale of
584,500  and 668,000 of their shares of common stock, respectively, at $5.99 per
share.  In  June  2000,  Drs.  Titomirov  and  Babenko  entered  into  a private
transaction  for  the  sale  of  835,000  and  275,550 of their shares of common
stock,  respectively,  at approximately $6.37 per share to Paul Capital Partners
VI  Holdings.  In  connection  with these transactions, Paul Capital Partners VI
Holdings   and   the  Weiss,  Peck  &  Greer  entities  became  parties  to  our
non-preferred  holder rights agreement and received certain registration rights.
In  the  event  that  we are able to effect a short form registration, we may be
required  to  file such a registration statement on not more than two occasions.
In  addition,  we  granted  certain  piggyback  registration rights by which the
parties   to   the  non-preferred  rights  agreement  can,  subject  to  certain
circumstances,  include shares of their common stock in a registration statement
filed  by  us. These short form and piggyback registration rights terminate five
years  from  the date of this prospectus. In addition, such rights shall earlier
terminate  if  the shares of a party to the agreement can be sold under Rule 144
in any 90 day period or if their share ownership falls below a certain level.

     In  June  2000,  we  sold  156,954  shares  of  our common stock to ETP/FBR
Genomic  Fund,  LP,  at  $6.37  per  share,  for  aggregate proceeds to us of $1
million  in  cash.  ETP/FBR  Genomic  Fund's  general partner is ETP/FBR Genomic
Venture  Capital  Partners,  LLC  which  is  controlled  by  Emerging Technology
Partners,  LLC.  ETP/FBR  Genomic  Fund, LP is a recently formed venture capital
fund  that  intends  to  invest  primarily  in  companies  involved  in genomics
technology.  Dr.  Wei  Wu  He,  one  of our directors, is the General Partner of
Emerging  Technology  Partners,  LLC,  a venture capital fund he founded. Dr. He
was  one  of  the  first  employees  at  Human  Genome Sciences, Inc. Dr. He has
assisted  us  with marketing our GenoMax product. We believe that a relationship
with  ETP/FBR  Genomic  Fund,  LP  will be an important strategic benefit in the
future.  A limited partner of ETP/FBR Genomic Fund, LP is under common ownership
with   FBR   Venture  Capital  Managers,  Inc.,  the  beneficial  owner  of  our
outstanding  shares  of  Series  A  stock  for  which Hooks Johnston, one of our
directors,  serves  as  the  Managing  Director.  In  August 2000, Dr. Bernstein
entered  into  a  private transaction with ETP/FBR Genomic Fund, LP for the sale
of  83,900  shares of common stock, at $6.30 per share. In connection with these
transactions,  ETP/FBR  Genomic  Fund, LP joined as a party to our non-preferred
holder  rights  agreement  and  received  certain  registration rights described
above.

     In  September  2000,  ETP/FBR  Genomic  Fund,  LP purchased an aggregate of
300,000   shares  of  our  common  stock  at  $11.00  per  share  from  existing
stockholders  and  option holders, including purchases of 65,000 shares from Dr.
Bernstein,  45,000 shares from Dr. Babenko, 35,000 shares from Mr. Sullivan, our
Senior  Vice  President  of  Marketing  and  Sales,  and  35,000 shares from Mr.
Lehnen, our Chief Financial


                                       66
<PAGE>

Officer.  Each  of  Messrs.  Bernstein,  Babenko,  Sullivan and Lehnen exercised
vested  options  in  order  to  deliver shares to ETP/FBR Genomic Fund, LP under
these  agreements. The options exercised by Messrs. Bernstein, Babenko, Sullivan
and  Lehnen  amounted,  in each case, to less than 5% of their respective vested
options.

     We  believe  that  the  terms of each of the transactions described in this
section  are  no  less  favorable  to  us  than that we could have obtained from
disinterested third parties.


                                       67
<PAGE>

                            PRINCIPAL STOCKHOLDERS

     The  following  table  sets  forth  certain information as of September 27,
2000 for:

     o each person, entity, or group known by us to own beneficially more than
       5% of our outstanding common stock;

     o each named executive officer and each of our directors; and

     o our directors and executive officers as a group.

     Unless  otherwise  indicated,  the address of each person identified is c/o
InforMax, Inc., 6010 Executive Boulevard, 10th Floor, Rockville, MD 20852.

     The  percentages  shown  are  based  on  13,657,720  shares of common stock
outstanding  prior  to  this  offering  as of September 27, 2000, and 18,657,720
shares  of  common  stock outstanding after this offering. A person is deemed as
of  any date to have "beneficial ownership" of any security that such person has
a  right to acquire within 60 days after such date. Pursuant to Rule 13d-3 under
the  Exchange Act, shares of common stock that a person has the right to acquire
pursuant  to  the  exercise  of  stock  options  held  by  that  holder that are
exercisable  within 60 days of September 27, 2000 are deemed outstanding for the
purpose  of  computing  the  percentage  ownership  of  that person, but are not
deemed  outstanding  for computing the percentage ownership of any other person.
Except  as  indicated  by footnote, and subject to community property laws where
applicable,  the  persons  named  in  the  table have sole voting and investment
power for all shares of common stock shown as beneficially owned by them.

<TABLE>
<CAPTION>
                                                    SHARES BENEFICIALLY
                                                           OWNED             SHARES BENEFICIALLY OWNED
                                                     PRIOR TO OFFERING            AFTER OFFERING
                                                  ------------------------   -------------------------
            NAME OF BENEFICIAL OWNER                 NUMBER       PERCENT       NUMBER        PERCENT
-----------------------------------------------   ------------   ---------   ------------   ----------
<S>                                               <C>            <C>         <C>            <C>
Alex Titomirov, Ph.D.(1) ......................    6,112,200        34.1%     6,112,200         26.7%
FBR Venture Capital Managers, Inc.(2) .........    4,444,312        32.5%     4,444,312         23.8%
 1001 19th Street
 Arlington, VA 22209
Hooks Johnston(3) .............................    4,444,312        32.5%     4,444,312         23.8%
Vadim Babenko, Ph.D.(4) .......................    2,434,950        15.2%     2,434,950         11.6%
James Bernstein, M.D.(5) ......................    1,948,619        12.7%     1,948,619          9.6%
Amersham Pharmacia Biotech, Inc.(6) ...........    1,587,747        11.6%     1,587,747          8.5%
 800 Centennial Avenue
 P.O. Box 1327
 Piscataway, NJ 08855-1327
Weiss, Peck & Greer, LLC(7) ...................    1,252,497         9.2%     1,252,497          6.7%
 One New York Plaza
 New York, New York 10004
Paul Capital Partners VI Holdings(8) ..........    1,110,550         8.1%     1,110,550          6.0%
 50 California Street
 Suite 3000
 San Francisco, CA 94111
Timothy Sullivan(9) ...........................      881,830         6.1%       881,830          4.5%
Joseph Lehnen(10) .............................      716,500         5.0%       716,500          3.7%
Harry D'Andrea(11) ............................        5,010           *          5,010            *
Andrew Whiteley ...............................           --          --             --           --
Wei Wu He(12) .................................      540,856         4.0%       540,856          2.9%
All directors and executive officers as a group
 (9 persons)(13) ..............................   17,084,277        72.8%    17,084,277         60.0%
</TABLE>

----------
*  Represents less than 1% of the outstanding shares of common stock.

(1)  Includes 4,258,333 shares issuable upon exercise of vested options.

(2)  Includes  2,161,265  shares of our Series A preferred stock to be converted
     into  3,609,312  shares of common stock immediately prior to the closing of
     this  offering.  All shares held by FBR/TVP II Employee Fund, L.P., FBR/TVP
     II  Employee  Fund  II,  L.P.,  FBR/TVP  II  Employee  Fund  III, L.P., FBR
     Technology  Venture  Partners II, L.P., and FBR Technology Venture Partners
     II  (QP), L.P. FBR Venture Capital Managers, Inc. is the general partner of
     each  of  the  limited partnerships. Mr. Johnston, one of our directors, is
     the Managing Director of FBR Venture Capital Managers, Inc.


                                       68
<PAGE>

(3)  Represents  shares  held  by  FBR/TVP  II  Employee  Fund, L.P., FBR/TVP II
     Employee  Fund II, L.P., FBR/TVP II Employee Fund III, L.P., FBR Technology
     Venture  Partners  II,  L.P.,  and FBR Technology Venture Partners II (QP),
     L.P.  FBR  Venture Capital Managers, Inc. is the general partner of each of
     the  limited  partnerships.  Mr.  Johnston  is  a  Managing Director of FBR
     Venture Capital Managers, Inc.

(4)  Includes 2,351,450 shares issuable upon exercise of vested options.

(5)  Includes  1,631,319  shares  issuable  upon  exercise  of  vested  options,
     417,500  of  which  are  held by family trusts over which Dr. Bernstein has
     voting and dispositive power.

(6)  Includes  950,747  shares  of  our Series B preferred stock to be converted
     into  1,587,747  shares of common stock immediately prior to the closing of
     this  offering.  Mr. Whiteley, one of our directors, is a Vice President of
     Amersham Pharmacia Biotech, Inc.

(7)  Represents  (a)  71,966  shares  held  of record by WPG Networking Overseas
     Master  Fund,  L.P., (b) 343,360 shares held of record by WPG Institutional
     Software  Fund,  L.P.,  (c)  300,902  shares held of record by WPG Raytheon
     Networking  Fund,  L.P.,  (d) 318,211 shares held of record by WPG Raytheon
     Software  Fund,  L.P.,  (e)  170,964  shares held of record by WPG Software
     Fund,  L.P.,  (f)  45,424  shares held of record by WPG Networking QP Fund,
     L.P.,  and  (g) 1,670 shares held of record by Raj Mehra. Messrs. Raj Mehra
     and  Ben Taylor are the general partners of each of the entities identified
     in  (a)  through (f) above and share voting and dispositive power for these
     shares.

(8)  The  general  partner  of  which  Paul  Capital Partners VI is Paul Capital
     Management, Inc. LLC, of which Bryon T. Sheets is the manager.

(9)  Represents 881,830 shares issuable upon exercise of vested stock options.

(10) Includes 686,500 shares issuable upon exercise of vested stock options.

(11) Includes 5,010 shares issuable upon exercise of vested stock options.

(12) Represents  540,856  shares  held  by  ETP/FBR  Genomic  Fund, LP, which is
     controlled  by Emerging Technology Partners, LLC, of which Dr. Wei Wu He is
     the General Partner.

(13) Includes 9,814,442 shares issuable upon exercise of vested stock options.

                                       69
<PAGE>

                         DESCRIPTION OF CAPITAL STOCK

     At  the  time of the closing of this offering, our authorized capital stock
will consist of 120 million shares, including:

   o 100   million   shares  of  common  stock,  par  value  $0.001  per  share,
     18,657,720  of  which will be outstanding upon completion of this offering;
     and

   o 20  million  shares  of preferred stock, par value $0.01 per share, none of
     which will be outstanding upon completion of this offering.

The  following  is  a  summary  of  various  provisions  of our common stock and
preferred  stock.  The  following summary does not purport to be complete and is
subject  to,  and is qualified in its entirety by, the provisions of our amended
and  restated  certificate  of  incorporation  and  amended and restated bylaws,
where such rights are set forth in full, and the provisions of applicable law.

COMMON STOCK

     As  of  September  27,  2000,  there  were 8,460,661 shares of common stock
issued  and  outstanding  and  held  of record by 68 stockholders. An additional
5,197,059  shares  of  our  common  stock  will  be  issued  upon  the automatic
conversion  of  all  outstanding shares of our preferred stock immediately prior
to  the  closing  of  this  offering.  There will be 18,657,720 shares of common
stock  outstanding after giving effect to the sale of the shares of common stock
offered  hereby. See "Shares Eligible for Future Sale" for information regarding
the number of shares of common stock underlying outstanding options.

     Voting  Rights.  The  holders  of our common stock are entitled to one vote
per  share  on all matters to be voted on by stockholders. Holders of our common
stock  are  not  entitled  to cumulate their votes in the election of directors.
Generally,  all  matters  on  which stockholders will vote must be approved by a
majority  of the votes entitled to be cast by all shares of common stock present
in  person  or  represented  by  proxy,  subject to any voting rights granted to
holders of any preferred stock.

     Dividends.  Holders  of  our  common stock are entitled to share ratably in
any  dividends  declared  by  our  board  of  directors, subject to any priority
dividend  rights  of  any  preferred stock we may issue in the future. We do not
intend  to  pay  cash  dividends on our common stock for the foreseeable future.
This  is because we intend to retain our cash for working capital and to finance
our  planned  growth.  However,  our  board  of  directors is free to change our
dividend  policy  in  the  future,  based  upon  factors  such as our results of
operations,  financial  condition,  cash flow, cash needs, and future prospects.
If  our  board  of  directors  were to change our dividend policy, so long as we
have  any amount outstanding under our credit facilities with PNC Bank, National
Association,  we would be required to obtain PNC Bank's written consent prior to
the declaration or payment of such dividends.

     Liquidation  Rights.  If we are liquidated, dissolved, or wound up, we must
first  pay  all  amounts  we  owe  our  creditors  and then pay the full amounts
required  to  be  paid  to  holders  of  any  shares of our preferred stock then
outstanding  before  we may make any payments to holders of shares of our common
stock.  All  holders of shares of our common stock are entitled to share ratably
in  any  assets  available  for distribution to them, after all of our creditors
have  been  satisfied and we have paid the liquidation preferences of any of our
preferred stock.

     Other  Rights.  No  shares of our common stock are subject to redemption by
us.  Holders  of shares of our common stock do not have any preemptive rights to
purchase additional shares of our common stock.

     All  of  our  shares  of  our  common  stock  to  be outstanding after this
offering will be validly issued, fully paid and nonassessable.

PREFERRED STOCK

     As  of  September  27,  2000, there were 3,112,012 shares of our redeemable
convertible  preferred  stock  authorized,  2,161,265  of  which were designated
Series  A  preferred  stock  and  950,747  of  which  were  designated  Series B
preferred  stock,  each issued and outstanding. Immediately prior to the closing
of  this  offering,  all  of  our  outstanding shares of preferred stock will be
converted into shares of our common stock.


                                       70
<PAGE>

     Our amended and restated certificate of incorporation  authorizes our board
of  directors  to create and issue  preferred  stock from time to time in one or
more  classes or series.  In creating and issuing a class or series of preferred
stock,  our board of directors,  without further vote of our  stockholders,  may
determine the exact terms of the class or series, including the following:

     o    the  number of shares  constituting  the  series  and the  distinctive
          designation of the series;

     o    the dividend rate on the shares of the series;  whether dividends will
          be cumulative,  and if so, from which date or dates,  and the relative
          rights of  priority,  if any, of payment of dividends on shares of the
          series;

     o    whether the series  will have voting  rights in addition to the voting
          rights provided by law, and if so, the terms of the voting rights;

     o    whether the series  will have  conversion  privileges  and, if so, the
          terms and conditions of conversion;

     o    whether the shares of the series will be  redeemable,  and, if so, the
          dates, terms, and conditions of redemption;

     o    whether  the series  will have a sinking  fund for the  redemption  or
          purchase of shares of that series, and, if so, the terms and amount of
          the sinking fund; and

     o    the rights of the  shares of the series in the event of our  voluntary
          or  involuntary  liquidation,  dissolution,  or  winding  up  and  the
          relative  rights or  priority,  if any,  of  payment  of shares of the
          series.

REGISTRATION RIGHTS

     Amersham  Pharmacia  Biotech,  each of the FBR  entities  disclosed  in the
"Principal  Stockholders" table, as assignees of FBR Technology Venture Partners
II, LP, each of the Weiss,  Peck & Greer entities  disclosed in such table, Paul
Capital Partners VI Holdings, PNC Bank, National Association, Raj Mehra, ETP/FBR
Genomic Fund, LP and three accredited investors have certain registration rights
as to the 8,541,276  shares of common stock or warrants to acquire  common stock
they will own upon the closing of this  offering.  The FBR entities are entitled
to certain demand  registration  rights pursuant to which they may require us to
file a  registration  statement  under the  Securities Act with respect to their
shares of common stock. Beginning on the date 180 days from the effectiveness of
our registration  statement in connection with this offering,  the FBR entities,
may, subject to certain conditions, require us to use our best efforts to effect
a registration statement on their behalf on not more than two occasions.  In the
event  that we are able to  register  our  shares  through  use of a  short-form
registration  under the Securities  Act, the FBR entities,  Amersham,  WPG, Paul
Capital,  ETP/FBR Genomic Fund, LP and the accredited  investors may, subject to
certain conditions require that we register their shares on such form,  provided
that we have not filed a short form registration within 12 months of the date of
the demand.  The FBR entities are  permitted up to four short form  registration
demands,  while  WPG,  Paul  Capital,  ETP/FBR  Genomic  Fund,  LP and the three
accredited  investors  together are permitted up to two short form  registration
demands.  Amersham  does not have a similar  limit with regard to its short form
registration rights.

     In the event that we propose to  register  any of our  securities  for sale
under the Securities Act, except for certain  employee  benefit plans or as part
of  certain  corporate  reorganizations,  each  of the  stockholders  above  are
entitled to notice of such  registration and to "piggyback" onto and include its
shares in that registration. These registration rights are subject to conditions
and limitations,  including the right of our underwriters to limit the number of
shares included in such offering and our right to delay registration  because it
would be seriously  detrimental  to us and our  stockholders.  All  registration
rights above terminate not later than five years from the date of  effectiveness
of our registration statement in this offering, except for the FBR entities' and
Amersham's  respective  "piggyback"  and short form  registration  rights  which
terminate when all shares held by the investor can be sold under Rule 144 in any
90 day  period,  or in the  case  of the  FBR  entities,  if the  FBR  entities'
ownership of our

                                       71

<PAGE>

stock  falls  below  1%  of  our  then  outstanding  shares.  We  are  generally
responsible  for the  costs  and  expenses  of all  such  registrations.  We are
required to obtain the consent of the holders of two-thirds of the FBR entities'
and  Amersham's  shares  prior  to the  granting  of  equal  or  more  favorable
registration rights to any third party.

SHAREHOLDERS' AGREEMENT

     We  are  party  to  a  shareholders'  agreement  with  Drs.  Titomirov  and
Bernstein, the "Founders," certain individual shareholders who together with the
Founders are  referred to as the  "Individual  Parties",  and each of the Weiss,
Peck  &  Greer  entities  noted  in  the  Principal  Stockholder  table.  Unless
terminated in writing,  the  agreement  continues in effect until the earlier of
the date on which all our  common  stock is owned by one of the  parties  to the
agreement  or such  date on which  more  than 50% of our  outstanding  shares of
common stock are  registered  under the Securities  Act. The agreement  provides
that so long as the Founders  continue to hold shares of common stock,  have not
departed from InforMax and are able to perform services for InforMax of at least
15 eight-hour days during any six month period, the Individual Parties will vote
all of their shares to elect each of the Founders to our board of directors. The
shareholders' agreement contains certain restrictions on transfer that limit the
ability of the parties to sell, transfer,  or otherwise dispose of their shares.
The agreement  provides that upon any separation  from InforMax of an Individual
Party,  we and the  remaining  Individual  Parties  have a  six-month  option to
purchase  all,  but  not  less  than  all of the  separated  party's  shares.  A
separation from InforMax includes, for example,  disability,  death, resignation
or  termination  other than for cause.  If we terminate  the  employment  of any
Founder for cause, we and the remaining Individual Parties will have a six month
option to purchase any or all of the terminated Founder's shares. The Individual
Parties may not sell,  transfer or otherwise  dispose of their shares to a third
party  without  giving the other parties  notice of their intent to sell,  and a
right of first refusal to purchase all, but not less than all, of such shares on
the same terms.  Transfer of shares to third persons,  including family members,
is permitted,  provided such persons become bound by the terms of the agreement.
During  the term of the  agreement,  and for a period  of two  years  after  its
termination,  the  Individual  Parties  have agreed not to compete,  directly or
indirectly,  with  us in the  development  and  licensing  of our  bioinformatic
software.  In  connection  with a private  sale  transaction,  Paul  Capital was
assigned  certain rights and assumed all obligations and  responsibilities  as a
shareholder party under the shareholders' agreement with regard to its shares of
common stock purchased from Dr. Titomirov.

DIRECTORS' LIABILITIES

     As permitted  by the  Delaware  General  Corporation  Law, as amended,  the
"DGCL," our certificate of  incorporation  limits the liability of our directors
to our company or our  stockholders for monetary damages for breach of fiduciary
duty as directors to the fullest  extent  permitted by the DGCL as it now exists
or as it may be amended.  As of the date of this  prospectus,  the DGCL  permits
limitations  of liability  for  director's  breach of fiduciary  duty other than
liability:

     o    for any breach of the director's duty of loyalty to our company or our
          stockholders,

     o    for acts or omissions  not in good faith or that  involve  intentional
          misconduct or a knowing violation of law,

     o    under Section 174 of the DGCL, or

     o    for any  transaction  from  which the  director  derived  an  improper
          personal benefit.

In addition,  our bylaws provide that we will  indemnify,  to the fullest extent
permitted under the DGCL, all of our directors,  officers,  employees and agents
for acts performed on our behalf in such capacity.

ANTI-TAKEOVER PROVISIONS OF CHARTER DOCUMENTS AND DELAWARE LAW

     We are subject to the  provisions  of Section 203 of the DGCL.  In general,
the statute  prohibits a publicly held Delaware  corporation  from engaging in a
"business  combination"  with an "interested  stockholder" for a period of three
years after the date that the person became an interested

                                       72

<PAGE>

stockholder  unless,  with some  exceptions,  the  business  combination  or the
transaction in which the person became an interested  stockholder is approved in
a prescribed  manner.  Generally,  a "business  combination"  includes a merger,
asset or stock sale or other transaction resulting in a financial benefit to the
stockholder,  and an  "interested  stockholder"  is a person who,  together with
affiliates and  associates,  owns, or within three years prior,  did own, 15% or
more of the corporation's outstanding voting stock.

     Immediately  prior to completion of this  offering,  our charter  documents
also will contain  provisions that may have the effect of delaying or preventing
changes in control or management of InforMax, which could have an adverse effect
on the market price of our common stock. For example, our charter documents will
contain a provision  eliminating  the ability of stockholders to take actions by
written  consent.  In  addition,   our  amended  and  restated   certificate  of
incorporation to be effective  immediately  prior to completion of this offering
provides that the board of directors  will be divided into three  classes,  each
serving staggered three-year terms, following the completion of this offering:

     o    Class I, whose  initial  term will  expire at the annual  meeting,  or
          special  meeting held in lieu of an annual  meeting,  of  stockholders
          held in 2001;

     o    Class II,  whose  initial term will expire at the annual  meeting,  or
          special  meeting held in lieu of an annual  meeting,  of  stockholders
          held in 2002; and

     o    Class III,  whose initial term will expire at the annual  meeting,  or
          special  meeting held in lieu of an annual  meeting,  of  stockholders
          held in 2003.

As a result,  only one class of directors will be elected at each annual meeting
of stockholders of InforMax, with the other classes continuing for the remainder
of their respective terms.

     Our amended and restated certificate of incorporation  permits our board of
directors  to issue up to 20 million  shares of  preferred  stock and to fix the
rights,  preferences,  privileges and restrictions,  including voting rights, of
these shares without any further vote or action by the  stockholders.  Issuances
of our  preferred  stock  could  have  the  effect  of  delaying,  deferring  or
preventing  a change  in  control,  as  removal  of our board of  directors  and
management may be rendered more difficult.  Issuances of our preferred stock may
have a negative impact on the ability of our  stockholders  to  participate,  if
applicable,  in a tender  offer or exchange  offer for the common  stock,  which
would diminish the value of our common stock.

     Further,  our issuance of preferred stock also could decrease the amount of
any  earnings and assets  available  for  distribution  to the holders of common
stock or could negatively affect the rights and powers, including voting rights,
of the holders of the common stock.

     Our bylaws will not permit our  stockholders  to call a special  meeting of
stockholders.  Under the bylaws,  only our  President,  Chairman of the board of
directors,  or a  majority  of the  board  of  directors  will be able to call a
special meeting.  The bylaws also require that  stockholders give advance notice
to our secretary of any nominations for director or other business to be brought
by  stockholders at any  stockholders'  meeting.  These  provisions may delay or
prevent changes of control or management.

TRANSFER AGENT

     The transfer  agent and  registrar  for our common stock is American  Stock
Transfer & Trust Company.

                                       73

<PAGE>

                         SHARES ELIGIBLE FOR FUTURE SALE

     Before this offering, there has been no public market for our common stock.
Future sales of substantial amounts of our common stock, or even the possibility
of future sales,  could reduce the prevailing  market price of our common stock.
As described  below,  only a limited number of shares of common stock  currently
held by our stockholders  will be available for sale shortly after this offering
because of contractual and legal  restrictions  on resale.  Sales of substantial
amounts of common stock in the public market after the restrictions  lapse could
negatively  affect the  prevailing  market price and our ability to raise equity
capital in the future.

     Upon the closing of this  offering,  18,657,720  shares of our common stock
will be  outstanding  based on the number of shares of our  preferred  stock and
common stock  outstanding  as of September 27, 2000, and assuming no exercise of
the underwriters'  over-allotment  option. Of these shares, the 5,000,000 shares
of common  stock being sold in this  offering  will be freely  tradable  without
restriction under the Securities Act, unless purchased by an "affiliate" of ours
as such term is defined in the Securities Act. The remaining  13,657,720  shares
of common  stock  were  issued and sold by us in  private  transactions  and are
"restricted  securities"  that are eligible  for public sale only if  registered
under the Securities Act or sold in compliance with Rule 144 under that Act.

     All of our officers,  directors,  and certain  shareholders,  including all
holders  of  1.5%  or  more  of our  outstanding  shares,  have  signed  lock-up
agreements,  in which they  agreed that they will not,  directly or  indirectly,
offer,  sell, or agree to sell, or otherwise dispose of any shares of our common
stock or other securities  without the prior written consent of Bear,  Stearns &
Co. Inc., for a period of 180 days from the date of this prospectus.

     Rule 144. In general,  under Rule 144 of the Securities Act as currently in
effect, beginning 90 days after the date of this prospectus, a person or persons
whose shares are aggregated,  who has beneficially  owned restricted  securities
for at least one year,  including the holding period of any earlier owner except
an affiliate, will be entitled to sell within any three month period a number of
shares that do not exceed the greater of:

     o    1% of the number of shares of our common stock then outstanding, which
          will  equal  approximately   186,577  shares  immediately  after  this
          offering; or

     o    the average  weekly  trading  volume of our common stock on the Nasdaq
          National  Market during the four calendar weeks before the filing of a
          notice on Form 144 with respect to the sale.

Sales under Rule 144 are also  subject to manner of sale  provisions  and notice
requirements and to the availability of current public information about us.

     Rule  144(k).  Under Rule  144(k) of the  Securities  Act as  currently  in
effect, a person who is not one of our affiliates at any time during the 90 days
before a sale, and who has beneficially owned the shares proposed to be sold for
at least two years,  including the holding period of any earlier owner except an
affiliate, is entitled to sell these shares without complying with the manner of
sale, public information, volume limitation, or notice provisions of Rule 144.

     Registration Rights. As described above, holders of 8,541,276 shares of our
common  stock,  or  warrants  to  acquire  common  stock,  that  are  restricted
securities  will be  entitled  to certain  registration  rights  covering  their
shares.  Registration  of their shares under the  Securities Act would result in
these shares becoming freely tradable without  restriction  under the Securities
Act immediately upon the effectiveness of that  registration,  except for shares
purchased by affiliates.

     Rule 701. In general,  under Rule 701 of the Securities Act as currently in
effect, any of our employees,  consultants,  or advisors, other than affiliates,
who purchases or receives shares from us in connection with our equity incentive
plan or  other  written  agreement  will be  eligible  to  resell  their  shares
beginning 90 days after the date of this prospectus,  subject only to the manner
of sale  provisions  of Rule 144.  Affiliates  will be able to sell such  shares
under Rule 144 without compliance with its holding period requirements.

                                       74

<PAGE>

     Stock  Options.  Following  this offering we intend to file a  registration
statement  on Form S-8 under the  Securities  Act  covering the shares of common
stock  underlying  options  held  by  our  officers,  directors  and  employees,
including shares reserved for issuance under our equity  incentive  compensation
plan. The  registration  statement on Form S-8 will become effective upon filing
with the  Securities and Exchange  Commission.  Accordingly,  shares  registered
under that  registration  statement will,  subject to limitations  applicable to
affiliates,  be available  for sale in the open market after the filing,  except
those shares subject to lock-up agreements and unvested shares.

                                       75

<PAGE>

                                  UNDERWRITING

     Subject to the terms and  conditions  provided  in an  agreement  among the
underwriters and us, the underwriters named below, through their representatives
Bear, Stearns & Co. Inc., U.S. Bancorp Piper Jaffray Inc. and Adams,  Harkness &
Hill,  Inc., have severally  agreed to purchase from us the aggregate  number of
shares of our common stock indicated opposite their names below:

<TABLE>
<CAPTION>

                                                                           NUMBER
         UNDERWRITER                                                      OF SHARES
         -----------                                                    ------------
         <S>                                                             <C>
         Bear, Stearns & Co. Inc. ...................................    1,925,000
         U.S. Bancorp Piper Jaffray Inc. ............................      787,500
         Adams, Harkness & Hill, Inc. ...............................      787,500
         Banc of America Securities LLC .............................      100,000
         Chase Securities, Inc. .....................................      100,000
         Dain Rauscher Incorporated .................................      100,000
         Deutsche Bank Securities Inc. ..............................      100,000
         Merrill Lynch, Pierce, Fenner & Smith Incorporated .........      100,000
         Morgan Stanley & Co. Incorporated ..........................      100,000
         Thomas Weisel Partners LLC .................................      100,000
         Robert W. Baird & Co. Incorporated .........................       50,000
         William Blair & Company, L.L.C. ............................       50,000
         Chatsworth Securities LLC ..................................       50,000
         Gaines, Berland Inc. .......................................       50,000
         Gerard Klauer Mattison & Co., LLC ..........................       50,000
         Jesup & Lamont Securities Corporation ......................       50,000
         Josephthal & Co. Inc. ......................................       50,000
         Ladenburg Thalmann & Co. Inc. ..............................       50,000
         Legg Mason Wood Walker, Incorporated .......................       50,000
         McDonald Investments Inc., a KeyCorp Company ...............       50,000
         Needham & Company, Inc. ....................................       50,000
         The Robinson-Humphrey Company, LLC .........................       50,000
         Sanders Morris Harris ......................................       50,000
         Sands Brothers & Co., Ltd. .................................       50,000
         Scott & Stringfellow, Inc. .................................       50,000
         Wunderlich Securities, Inc. ................................       50,000
         Total ......................................................    5,000,000
 </TABLE>

     The  underwriting  agreement  provides that the  obligations of the several
underwriters  are subject to approval of various  legal matters by their counsel
and to various other  conditions,  including  delivery of legal  opinions by our
counsel,  the delivery of a letter by our independent  auditors and the accuracy
of the representations and warranties made by us in the underwriting  agreement.
Under the underwriting  agreement,  the underwriters are obliged to purchase and
pay for all the above shares of our common stock if any are purchased.

PUBLIC OFFERING PRICE

     The  underwriters  propose to offer the shares of our common stock directly
to the  public  at the  offering  price  indicated  on the  cover  page  of this
prospectus  and at that price less a concession not in excess of $0.67 per share
of common stock to other dealers who are members of the National  Association of
Securities  Dealers,  Inc. The  underwriters  may allow,  and those  dealers may
reallow,  concessions  not in excess of $0.10 per share of common stock to other
underwriters  or to other  dealers.  After this  offering,  the offering  price,
concessions  and other  selling  terms may be changed by the  underwriters.  Our
common stock is offered  subject to receipt and  acceptance by the  underwriters
and subject to other  conditions,  including the right to reject orders in whole
or in part.  The  underwriters  have  informed us that the  underwriters  do not
expect to confirm sales of common stock to any accounts over which they exercise
discretionary authority.

                                       76

<PAGE>

     The  following  table  summarizes  the per share and total public  offering
price  of  the  shares  of  common  stock  in  the  offering,  the  underwriting
compensation  to be paid to the  underwriters  by us,  and the  proceeds  of the
offering,  before expenses,  to us. The information  presented assumes either no
exercise or full exercise by the underwriters of their over-allotment option.

<TABLE>
<CAPTION>
                                                                                             TOTAL
                                                                               ----------------------------------
                                                                                    WITHOUT             WITH
                                                                  PER SHARE     OVER-ALLOTMENT     OVER-ALLOTMENT
                                                                 -----------   ----------------   ---------------
<S>                                                              <C>           <C>                <C>
Public offering price ........................................    $  16.00        $80,000,000       $92,000,000
Underwriting discounts and commissions payable by us .........        1.12          5,600,000         6,440,000
Proceeds, before expenses, to us .............................       14.88         74,400,000        85,560,000
</TABLE>

     The  underwriting  discount and commission per share is equal to the public
offering  price  per  share of our  common  stock  less the  amount  paid by the
underwriters to us per share of common stock.

     We estimate total expenses  payable by us in connection with this offering,
other than the underwriting discounts and commissions referred to above, will be
approximately $ 1,200,000.

OVER-ALLOTMENT OPTION TO PURCHASE ADDITIONAL SHARES

     We have  granted  a 30-day  over-allotment  option to the  underwriters  to
purchase up to an  aggregate  of 750,000  additional  shares of our common stock
exercisable  at  the  offering  price  less  the   underwriting   discounts  and
commissions,  each as  provided  on the cover  page of this  prospectus.  If the
underwriters  exercise  this  option  in  whole  or in  part,  then  each of the
underwriters will be obligated to purchase  additional shares of common stock in
proportion to their  respective  purchase  commitments as shown in the table set
forth above, subject to various conditions.

INDEMNIFICATION AND CONTRIBUTION

     The underwriting agreement provides that we will indemnify the underwriters
against liabilities specified in the underwriting agreement under the Securities
Act, including  liabilities arising from material  misstatements or omissions in
connection with disclosure, or will contribute to payments that the underwriters
may be required to make in respect of those  liabilities.  The underwriters have
agreed  to  indemnify  us  against  liabilities  specified  in the  underwriting
agreement under the Securities Act. Insofar as  indemnification  for liabilities
arising  under the  Securities  Act may be  permitted to the  underwriters,  the
underwriters  have been  advised  that,  in the  opinion of the  Securities  and
Exchange Commission,  such indemnification is against public policy as expressed
in the Securities Act and is, therefore, unenforceable.

LOCK-UP AGREEMENTS

     Our directors and officers and certain stockholders,  including all holders
of 1.5% or more of our  outstanding  shares,  have  agreed  that  they will not,
directly or indirectly,  offer,  sell or agree to sell, or otherwise  dispose of
any shares of our  common  stock or  convertible  securities  without  the prior
written  consent of Bear,  Stearns & Co. Inc.  for a period of 180 days from the
date of this prospectus.

     In addition,  we have agreed that for a period of 180 days from the date of
this prospectus, we will not, without the prior written consent of Bear, Stearns
& Co. Inc., directly or indirectly:

     o    issue,  offer,  sell,  grant any  option,  warrant  or other  right to
          purchase  or  otherwise  dispose  of any  shares  of  common  stock or
          convertible securities,

     o    pledge, make any short sale or maintain any short position,  establish
          or maintain a put position,

     o    enter into any swap, derivative  transaction or other arrangement that
          transfers to another any of the economic  consequences of ownership of
          common stock, or

     o    otherwise dispose of any common stock or convertible securities or any
          interest in our common stock or convertible securities.

                                       77

<PAGE>

     During this lock-up period,  we may,  however,  issue, and grant options to
purchase, shares of common stock and restricted stock under our equity incentive
compensation  plan, so long as the  recipients of any such shares are themselves
subject to the 180 day lock-up.  During this lock-up period,  subject to various
conditions,  we may also issue additional common stock or securities convertible
into common stock in connection with collaborative and licensing arrangements or
to pay for possible  acquisitions,  so long as the recipients of such securities
are also subject to the 180 day lock-up period.

NASDAQ NATIONAL MARKET QUOTATION

     Before this offering, there has been no public market for our common stock.
As a result,  the initial  public  offering  price for the common stock has been
determined  by  negotiations   between  us  and  the   representatives   of  the
underwriters.  Among the factors  considered in  determining  the initial public
offering  price  were our  future  prospects  and the  future  prospects  of our
industry  in  general,  our sales,  earnings  and certain  other  financial  and
operating  information  in  recent  periods,  and  the  price-earnings   ratios,
price-sales  ratios,  market  prices of  securities  and certain  financial  and
operating  information of companies  engaged in activities  similar to ours. Our
common stock has been approved for listing on the Nasdaq National Market,  under
the symbol  "INMX." We cannot  assure  you,  however,  that an active or orderly
trading  market will  develop for our common stock or that the common stock will
trade in the public  market  subsequent to this offering at or above the initial
offering price.

STABILIZATION, SYNDICATE SHORT POSITION AND PENALTY BIDS

     In order to facilitate the offering of our common stock,  the  underwriters
may engage in transactions  that stabilize,  maintain,  or otherwise  affect the
market price of our common stock.

     The  underwriters  may over-allot  shares of our common stock in connection
with this offering,  thus creating a short position for their own account. Short
sales involve the sale by the  underwriters  of a greater  number of shares than
they are  committed to purchase in the  offering.  A short  position may involve
either  "covered"  short sales or "naked"  short sales.  Covered short sales are
sales made in an amount not greater than the underwriters' over-allotment option
to purchase  additional shares in the offering described above. The underwriters
may  close  out  any  covered  short   position  by  either   exercising   their
over-allotment  option or purchasing  shares in the open market.  In determining
the source of shares to close the covered short position,  the underwriters will
consider,  among other things, the price of shares available for purchase in the
open market as compared to the price at which they may purchase  shares  through
the  over-allotment  option.  Naked  short  sales  are  sales in  excess  of the
over-allotment  option. The underwriters must close out any naked short position
by purchasing  shares in the open market.  A naked short position is more likely
to be created  if the  underwriters  are  concerned  that there may be  downward
pressure on the price of the shares in the open market after  pricing that could
adversely affect investors who purchase in the offering.

     Accordingly,  to cover these  short sales  positions  or to  stabilize  the
market price of our common stock,  the  underwriters  may bid for, and purchase,
shares  of our  common  stock  in the open  market.  These  transactions  may be
effected  on  the  Nasdaq  National  Market  or  otherwise.   Additionally,  the
representatives,  on  behalf  of the  underwriters,  may  also  reclaim  selling
concessions  allowed  to an  underwriter  or dealer.  Similar to other  purchase
transactions,  the underwriters' purchases to cover the syndicate short sales or
to stabilize the market price of our common stock may have the effect of raising
or maintaining  the market price of our common stock or preventing or mitigating
a decline in the market  price of our common  stock.  As a result,  the price of
shares of our common  stock may be higher  than the price  that might  otherwise
exist in the open  market.  No  representation  is made as to the  magnitude  or
effect of any such  stabilization or other activities.  The underwriters are not
required to engage in these  activities and, if commenced,  may end any of these
activities at any time.

DIRECTED SHARE PROGRAM

     At our  request,  the  underwriters  have  reserved for sale at the initial
public  offering  price up to 250,000  shares of common stock to be sold in this
offering for sale to our directors,  officers,  employees,  business associates,
vendors and related persons. Purchases of reserved shares are to be

                                       78

<PAGE>

made  through an account at Bear,  Stearns & Co. Inc. in  accordance  with Bear,
Stearns & Co.  Inc.'s  procedures  for  opening an account  and  transacting  in
securities.  The number of shares  available for sale to the general public will
be reduced to the extent that any reserved  shares are  purchased.  Any reserved
shares not purchased by our directors, officers, employees, business associates,
vendors and related  persons will be offered by the  underwriters to the general
public on the same terms as the other shares offered by this prospectus.

                                  LEGAL MATTERS

     Certain legal matters, including the legal validity of the shares of common
stock  we are  offering,  will be  passed  upon for us by our  counsel,  Hogan &
Hartson L.L.P.,  Washington,  D.C. Certain legal matters in connection with this
offering will be passed upon for the underwriters by Coudert Brothers, New York,
New York. A partner of Hogan & Hartson L.L.P. beneficially owns 56,359 shares of
our common stock.

                                     EXPERTS

     The consolidated  financial statements as of December 31, 1998 and 1999 and
for each of the three years in the period ended  December  31, 1999  included in
this  prospectus  have  been  audited  by  Deloitte  & Touche  LLP,  independent
auditors,  as stated in their report appearing herein, and have been so included
in reliance  upon the report of such firm given upon their  authority as experts
in accounting and auditing.

                             ADDITIONAL INFORMATION

     We have filed a registration  statement on Form S-1 with the Securities and
Exchange  Commission  under the Securities Act covering the shares of our common
stock offered by this prospectus.  The registration  statement  contains certain
exhibits and  schedules  described  in this  prospectus.  While the  information
contained in this prospectus is complete in all material respects, the full text
of  contracts  or  documents  that are  filed as  exhibits  to the  registration
statement  are  available  for  your  review,   excluding   portions  for  which
confidential   treatment  has  been  granted  by  the  Securities  and  Exchange
Commission.  A copy of our  registration  statement,  including the exhibits and
schedules,  may be read and copied at the Securities  and Exchange  Commission's
Public  Reference  Room at 450  Fifth  Street,  N.W.,  Washington,  D.C.  20549.
Information  on the  operation of the Public  Reference  Room may be obtained by
calling the  Securities  and Exchange  Commission at  1-800-SEC-0330.  Also, the
Securities   and   Exchange   Commission   maintains   an   Internet   site   at
http://www.sec.gov,  from which you can  electronically  access our registration
statement, including the exhibits and schedules attached to it.

     As a  result  of  this  offering,  we  will  become  subject  to  the  full
informational  requirements of the Securities Exchange Act of 1934. We intend to
fulfill these requirements by filing periodic reports and other information with
the Securities and Exchange  Commission.  We intend to furnish our  stockholders
with annual reports containing consolidated financial statements certified by an
independent public accounting firm.

                                       79

<PAGE>

                  INDEX TO CONSOLIDATED FINANCIAL STATEMENTS

<TABLE>
<CAPTION>

                                                                                          PAGE
                                                                                          -----
<S>                                                                                       <C>
Independent Auditors' Report ............................................................ F-2
Consolidated Balance Sheets as of December 31, 1998 and 1999 and as of
 June 30, 2000 -- actual and proforma, (unaudited) ...................................... F-3
Consolidated Statements of Operations for the years ended December 31, 1997, 1998
 and 1999 and for the six months ended June 30, 1999 and 2000 (unaudited) ............... F-5
Consolidated Statements of Changes in Stockholders' Equity (Deficit) for the years
 ended December 31, 1997, 1998 and 1999 and for the six months ended
 June 30, 2000 (unaudited) .............................................................. F-6
Consolidated Statements of Cash Flows for the years ended December 31, 1997, 1998
 and 1999 and for the six months ended June 30, 1999 and 2000 (unaudited) ............... F-7
Notes to Consolidated Financial Statements .............................................. F-10
</TABLE>

                                       F-1

<PAGE>

                          INDEPENDENT AUDITORS' REPORT

To the Board of Directors of
InforMax, Inc. and Subsidiary
Rockville, Maryland

We have audited the accompanying  consolidated balance sheets of InforMax,  Inc.
and  subsidiary as of December 31, 1998 and 1999,  and the related  consolidated
statements of operations,  changes in stockholders'  equity (deficit),  and cash
flows for each of the three years in the period ended  December 31, 1999.  These
financial  statements are the  responsibility of the Company's  management.  Our
responsibility  is to express an opinion on these financial  statements based on
our audits.

We conducted our audits in accordance with auditing standards generally accepted
in the  United  States of  America.  Those  standards  require  that we plan and
perform the audit to obtain  reasonable  assurance  about  whether the financial
statements are free of material misstatement.  An audit includes examining, on a
test basis,  evidence  supporting  the amounts and  disclosures in the financial
statements.  An audit also includes assessing the accounting principles used and
significant  estimates  made by  management,  as well as evaluating  the overall
financial  statement  presentation.   We  believe  that  our  audits  provide  a
reasonable basis for our opinion.

In our opinion,  such consolidated  financial  statements present fairly, in all
material respects, the financial position of InforMax, Inc. and subsidiary as of
December 31, 1998 and 1999,  and the results of their  operations and their cash
flows for each of the three years in the period  ended  December  31,  1999,  in
conformity with accounting principles generally accepted in the United States of
America.

DELOITTE & TOUCHE LLP


McLean, Virginia

June 7, 2000,  except for Note 16,  paragraphs  six,  seven,  eight,  nine, ten,
eleven,  twelve,  thirteen,  fourteen and fifteen as to which the dates are June
19, 2000, June 23, 2000, June 29, 2000, June 30, 2000, July 7, 2000,  August 16,
2000,  September 8, 2000,  September 11, 2000,  September 21, 2000 and September
26, 2000, respectively.

                                       F-2

<PAGE>

                                INFORMAX, INC.

                           CONSOLIDATED BALANCE SHEETS

<TABLE>
<CAPTION>

                                                       DECEMBER 31,                     JUNE 30, 2000
                                               -----------------------------   --------------------------------
                                                                                                   (PRO FORMA)
                                                    1998            1999            ACTUAL          (NOTE 2)
                   ASSETS                      -------------   -------------   ---------------   --------------
                                                                                 (UNAUDITED)       (UNAUDITED)
<S>                                            <C>             <C>             <C>               <C>
Current assets:
 Cash and cash equivalents .................    $  295,669      $1,398,937       $ 2,090,541      $12,090,541
 Accounts receivable (net of allowance for
   doubtful accounts of $15,000 at December
   31, 1998 and 1999 and $20,000 at June 30,
   2000 (unaudited)), respectively .........     1,550,328       2,640,485         3,666,023        3,666,023
 Income tax receivable .....................            --         122,446                --               --
 Deferred tax asset ........................       581,353         676,379            52,872           52,872
 Prepaid expenses ..........................            --         222,473           192,157          192,157
 Deferred offering costs ...................            --              --           373,740          373,740
 Other current assets ......................         9,435          28,837            35,731           35,731
                                                ----------      ----------       -----------      -----------
    Total current assets ...................     2,436,785       5,089,557         6,411,064       16,411,064
                                                ----------      ----------       -----------      -----------
Property and equipment:
 Computer equipment ........................       434,669       1,060,435         1,684,488        1,684,488
 Purchased software ........................         4,340          58,306           118,822          118,822
 Office furniture and equipment ............        46,236         537,908         1,063,212        1,063,212
 Leasehold improvements ....................            --         155,122           243,316          243,316
                                                ----------      ----------       -----------      -----------
                                                   485,245       1,811,771         3,109,838        3,109,838
 Less: Accumulated depreciation and

   amortization ............................      (114,426)       (375,472)         (717,989)        (717,989)
                                                ----------      ----------       -----------      -----------
    Property and equipment - net ...........       370,819       1,436,299         2,391,849        2,391,849
                                                ----------      ----------       -----------      -----------
Other assets:
 Deposits ..................................        10,883          67,996            81,519           81,519
 Loan to shareholder .......................            --          69,360                --               --
 Deferred tax asset ........................        64,341         601,500         1,225,007        1,225,007
                                                ----------      ----------       -----------      -----------
    Total other assets .....................        75,224         738,856         1,306,526        1,306,526
                                                ----------      ----------       -----------      -----------
Total assets ...............................    $2,882,828      $7,264,712       $10,109,439      $20,109,439
                                                ==========      ==========       ===========      ===========
</TABLE>

                See notes to consolidated financial statements.

                                       F-3

<PAGE>
                                INFORMAX, INC.

                           CONSOLIDATED BALANCE SHEETS

<TABLE>
<CAPTION>

                                                                       DECEMBER 31,                   JUNE 30, 2000
                                                               ----------------------------- -------------------------------
                                                                                                                PRO FORMA

                                                                    1998           1999           ACTUAL         (NOTE 2)
LIABILITIES AND STOCKHOLDERS' EQUITY (DEFICIT)                 ------------- --------------- --------------- ---------------
                                                                                               (UNAUDITED)     (UNAUDITED)
<S>                                                            <C>           <C>             <C>             <C>
 Accounts payable ............................................  $  391,477    $    404,016    $  1,145,226    $  1,145,226
 Accounts payable to related parties .........................      23,325          21,806         352,847         352,847
 Accrued liabilities .........................................     341,972         933,125         484,488         484,488
 Line of credit ..............................................     200,000         550,000       1,650,000       1,650,000
 Equipment loan facility - current portion ...................          --         337,302         664,000         664,000
 Notes payable ...............................................      64,415              --              --              --
 Capital lease obligations - current portion .................     114,106         113,293          96,815          96,815
 Deferred revenue ............................................   1,489,389       1,689,997       3,301,025       3,301,025
 Income taxes payable ........................................     151,296              --              --              --
 Billings in excess of cost on government contracts ..........      79,796              --              --              --
                                                                ----------    ------------    ------------    ------------
    Total current liabilities ................................   2,855,776       4,049,539       7,694,401       7,694,401
                                                                ----------    ------------    ------------    ------------
Long-term liabilities:
 Capital lease obligations - less current portion ............     182,346          92,208          48,873          48,873
 Equipment loan facility - less current portion ..............          --         623,245       1,241,973       1,241,973
 Deferred revenue ............................................     249,886         121,673         309,704         309,704
                                                                ----------    ------------    ------------    ------------
    Total long-term liabilities ..............................     432,232         837,126       1,600,550       1,600,550
                                                                ----------    ------------    ------------    ------------
Commitments and contingencies

 (Notes 13 and 14 ) ..........................................
Series A redeemable convertible preferred stock, par value
  $0.01; no shares authorized, issued and outstanding at
  December 31, 1998, 2,161,265 shares authorized, issued, and
  outstanding at December 31, 1999 and June 30, 2000
  (unaudited) and no shares authorized, issued and outstanding
  at June 30, 2000 pro forma (unaudited),

 liquidation preference - $1.85 per share.....................          --       4,095,054       4,263,194              --
                                                                ----------    ------------    ------------    ------------

Series B redeemable convertible preferred stock, par value
  $0.01--no shares authorized, issued and outstanding at
  December 31, 1998 and 1999, June 30, 2000 (unaudited),

 and June 30, 2000 pro forma (unaudited) .....................          --              --              --              --
                                                                ----------    ------------    ------------    ------------
Stockholders' equity (deficit):



 Common stock - voting, par value $0.001; 100,000,000 shares
  authorized; 1,914,822, 2,505,000, 2,254,500, and 12,983,068
  shares issued, and 1,664,322, 2,254,500, 2,254,500, and
  12,983,068 shares outstanding at December 31, 1998 and 1999,
  June 30, 2000 (unaudited), and June 30, 2000 pro forma

   (unaudited), respectively .................................       1,915           2,505           2,255          12,983
 Common stock - nonvoting, par value $0.001; 14,931,864
  shares authorized; 2,387,098, 2,034,060, 5,531,508 and no
  shares issued, and 2,069,798, 1,716,760, 5,531,508, and no
  shares outstanding at December 31, 1998 and 1999, June 30,
  2000 (unaudited) and June 30, 2000 pro

   forma (unaudited), respectively ...........................       2,387           2,034           5,531              --
 Subscription receivable .....................................          --              --      (1,013,436)     (1,013,436)
 Additional paid-in capital ..................................     583,865         970,806       6,260,877      20,518,874
 Deferred compensation .......................................     (16,218)       (400,208)       (461,734)       (461,734)
 Accumulated deficit .........................................    (858,129)     (2,173,144)     (8,242,199)     (8,242,199)
 Treasury stock, 567,800 shares at cost at December 31,
   1998 and 1999 and no shares at June 30, 2000
   (unaudited) and June 30, 2000 pro forma (unaudited),
   respectively ..............................................    (119,000)       (119,000)             --              --
                                                                ----------    ------------    ------------    ------------
    Total stockholders' equity (deficit) .....................    (405,180)     (1,717,007)     (3,448,706)     10,814,488
                                                                ----------    ------------    ------------    ------------
Total liabilities and stockholders' equity (deficit) .........  $2,882,828    $  7,264,712    $ 10,109,439    $ 20,109,439
                                                                ==========    ============    ============    ============
</TABLE>
                See notes to consolidated financial statements.

                                       F-4

<PAGE>

                                INFORMAX, INC.

                      CONSOLIDATED STATEMENTS OF OPERATIONS

<TABLE>
<CAPTION>

                                                                                                         SIX MONTHS ENDED
                                                                YEAR ENDED DECEMBER 31,                      JUNE 30,
                                                      ------------------------------------------- -------------------------------
                                                           1997          1998           1999            1999            2000
                                                      ------------- ------------- --------------- --------------- ---------------
                                                                                                    (UNAUDITED)     (UNAUDITED)
<S>                                                   <C>           <C>           <C>             <C>             <C>
Revenues:
 Software license and customer support ..............  $1,334,510    $2,732,382    $  7,277,627     $ 3,321,877    $  4,854,534
 Professional services ..............................     867,212     1,393,863       2,736,798       1,159,250       1,655,395
                                                       ----------    ----------    ------------     -----------    ------------
    Total revenues ..................................   2,201,722     4,126,245      10,014,425       4,481,127       6,509,929
                                                       ----------    ----------    ------------     -----------    ------------
Cost of revenues:
 Software license and customer support ..............      38,102       190,144         404,848         146,857         233,031
 Professional services(1) ...........................     716,059     1,081,021       1,612,167         730,757         879,949
                                                       ----------    ----------    ------------     -----------    ------------
    Total cost of revenues ..........................     754,161     1,271,165       2,017,015         877,614       1,112,980
                                                       ----------    ----------    ------------     -----------    ------------
Gross profit ........................................   1,447,561     2,855,080       7,997,410       3,603,513       5,396,949
                                                       ----------    ----------    ------------     -----------    ------------
Operating expenses:
 Selling, general and administrative(2) .............   1,075,264     2,475,840       6,999,916       2,396,848       7,564,959
 Research and development(3) ........................     365,034     1,162,471       2,597,281       1,129,298       2,471,185
 Stock based compensation ...........................     210,695        17,782         138,185          26,391         974,613
 Depreciation and amortization ......................      17,945        93,809         272,548          88,872         342,984
                                                       ----------    ----------    ------------     -----------    ------------
    Total operating expenses ........................   1,668,938     3,749,902      10,007,930       3,641,409      11,353,741
                                                       ----------    ----------    ------------     -----------    ------------
Loss from operations ................................    (221,377)     (894,822)     (2,010,520)        (37,896)     (5,956,792)
                                                       ----------    ----------    ------------     -----------    ------------
Other income (expense):
 Investment earnings ................................          --            --          66,342           2,104          15,769
 Interest expense ...................................     (18,523)      (59,910)        (86,538)        (32,927)       (120,005)
 Other ..............................................     (12,404)       (3,313)        (10,642)             --          (8,027)
                                                       ----------    ----------    ------------     -----------    ------------
    Total other income (expense) ....................     (30,927)      (63,223)        (30,838)        (30,823)       (112,263)
                                                       ----------    ----------    ------------     -----------    ------------
Loss before income taxes ............................    (252,304)     (958,045)     (2,041,358)        (68,719)     (6,069,055)
Income tax provision (benefit) ......................    (118,224)     (391,291)       (726,343)         12,870              --
                                                       ----------    ----------    ------------     -----------    ------------
Net loss ............................................    (134,080)     (566,754)     (1,315,015)        (81,589)     (6,069,055)
Accretion of transaction costs on redeemable
 convertible preferred stock ........................  $       --    $       --    $     (8,139)    $        --    $     (8,136)
Accrued dividend on redeemable convertible
 preferred stock ....................................          --            --        (168,300)             --        (160,002)
                                                       ----------    ----------    ------------     -----------    ------------
Net loss applicable to common shares ................  $ (134,080)   $ (566,754)   $ (1,491,454)    $   (81,589)   $ (6,237,193)
                                                       ==========    ==========    ============     ===========    ============
Basic net loss applicable per common share(4) .......  $    (0.04)   $    (0.16)   $      (0.38)    $     (0.02)   $      (1.18)
                                                       ==========    ==========    ============     ===========    ============
Diluted net loss applicable per common share(4) .....  $    (0.04)   $    (0.16)   $      (0.38)    $     (0.02)   $      (1.18)
                                                       ==========    ==========    ============     ===========    ============
Weighted average common shares outstanding -
 Basic and diluted(4) ...............................   3,132,753     3,611,626       3,874,122       3,795,131       5,268,665
                                                       ==========    ==========    ============     ===========    ============
</TABLE>


------------------
(1) Cost of revenues -- professional  services includes stock based compensation
    of $105,539,  $-0-,  $-0-, $-0-, and $5,497 for the years ended December 31,
    1997,  1998, and 1999 and the six month periods ended June 30, 1999 and 2000
    (unaudited), respectively.

(2) Selling,  general and  administrative  expenses includes related party legal
    expenses of $4,751, $21,256, $227,000,  $142,608 and $136,832 and consulting
    expenses of $-0-, $34,333,  $120,833, $53,000 and $25,000 and excludes stock
    based compensation of $76,189,  $-0-, $111,019,  $9,643 and $845,741 for the
    years ended  December 31, 1997,  1998,  and 1999 and six month periods ended
    June 30, 1999 and 2000 (unaudited), respectively.

(3) Research and  development  expenses  excludes  stock based  compensation  of
    $134,506,  $17,782,  $27,166,  $16,748  and  $128,874  for the  years  ended
    December 31, 1997,  1998 and 1999 and the six month  periods  ended June 30,
    1999 and 2000, (unaudited) respectively.

(4) As restated for the unaudited six month period ended June 30, 2000, see Note
    6.

                See notes to consolidated financial statements.

                                       F-5

<PAGE>

                                INFORMAX, INC.
     CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY (DEFICIT)

<TABLE>
<CAPTION>

                                             COMMON STOCK - VOTING                           COMMON STOCK - NONVOTING
                                          ----------------------------            ----------------------------------------------
                                              ISSUED      OUTSTANDING                  ISSUED         OUTSTANDING
                                              SHARES         SHARES      AMOUNT        SHARES           SHARES         AMOUNT
                                          -------------- ------------- ---------- ---------------- ---------------- ------------
<S>                                       <C>            <C>           <C>        <C>              <C>              <C>
Balance, January 1, 1997 ................    1,914,822     1,914,822    $ 1,915        1,652,131        1,652,131         1,652
Purchase of treasury stock ..............           --      (250,500)        --                          (317,300)           --
Issuance of stock options ...............           --            --         --               --               --            --
Net loss ................................           --            --         --               --               --            --
                                             ---------     ---------    -------        ---------        ---------         -----
Balance, December 31, 1997 ..............    1,914,822     1,664,322    $ 1,915        1,652,131        1,334,831         1,652
Share options exercised .................           --            --         --          734,967          734,967           735
Issuance of stock options ...............           --            --         --               --               --            --
Amortization of deferred

 compensation on stock options ..........           --            --         --               --               --            --
Net loss ................................           --            --         --               --               --            --
                                             ---------     ---------    -------        ---------        ---------         -----
Balance, December 31, 1998 ..............    1,914,822     1,664,322    $ 1,915        2,387,098        2,069,798         2,387
Conversion -- non-voting shares to
 voting .................................      590,178       590,178        590         (590,178)        (590,178)         (590)
Issuance of common stock ................           --            --         --          100,200          100,200           100
Share options exercised .................           --            --         --          136,940          136,940           137
Issuance of stock options ...............           --            --         --               --               --            --
Amortization of deferred
 compensation on stock options
 and restricted stock ...................           --            --         --               --               --            --
Accretion of transaction costs on
 redeemable convertible preferred
 stock ..................................           --            --         --               --               --            --
Accrual of dividend on redeemable
 convertible preferred stock ............           --            --         --               --               --            --
Net loss ................................           --            --         --               --               --            --
                                             ---------     ---------    -------        ---------        ---------         -----
Balance, December 31, 1999 ..............    2,505,000     2,254,500      2,505        2,034,060        1,716,760         2,034
Share options exercised .................           --            --                   3,257,555        3,257,555         3,257
Issuance of stock options ...............           --            --         --               --               --            --
Issuance of common stock ................                                                557,193          557,193           557
Issuance of warrants ....................
Adjustments to deferred
 compensation for variable stock
 options and restricted stock ...........           --            --         --               --               --            --
Amortization of deferred
 compensation on stock options
 and restricted stock ...................           --            --         --               --               --            --
Accretion of transaction costs on
 redeemable convertible preferred
 stock ..................................           --            --         --               --               --            --
Accrual of dividend on redeemable
 convertible preferred stock ............           --            --         --               --               --            --
Retirement of treasury stock ............     (250,500)                    (250)        (317,300)                          (317)
Net loss ................................           --            --         --               --               --            --
                                             ---------     ---------    -------        ---------        ---------         -----
Balance, June 30, 2000 (unaudited) ......    2,254,500     2,254,500      2,255        5,531,508        5,531,508         5,531
Pro forma conversion of redeemable
 convertible preferred stock to
 common stock (unaudited) ...............      579,979       579,979        580        4,617,081        4,617,081         4,617
Pro forma conversion of nonvoting
 to voting common stock
 (unaudited) ............................   10,148,589    10,148,589     10,148      (10,148,589)     (10,148,589)      (10,148)
                                            ----------    ----------    -------      -----------      -----------       -------
Pro forma balance, June 30, 2000
 (unaudited) ............................   12,983,068    12,983,068    $12,983               --               --    $       --
                                            ==========    ==========    =======      ===========      ===========    ==========



<CAPTION>
                                                TREASURY STOCK
                                          ---------------------------
                                                                         ADDITIONAL
                                                                          PAID-IN        DEFERRED      SUBSCRIPTION
                                              SHARES        AMOUNT        CAPITAL     COMPENSATION      RECEIVABLE
                                          ------------- ------------- --------------- -------------- ----------------
<S>                                       <C>           <C>           <C>             <C>            <C>
Balance, January 1, 1997 ................          --    $        --    $   229,965     $       --     $         --
Purchase of treasury stock ..............     567,800       (119,000)            --             --               --
Issuance of stock options ...............          --             --        316,234             --               --
Net loss ................................          --             --             --             --               --
                                              -------    -----------    -----------     ----------     ------------
Balance, December 31, 1997 ..............     567,800       (119,000)       546,199             --               --
Share options exercised .................          --             --          3,666             --               --
Issuance of stock options ...............          --             --         34,000        (34,000)              --
Amortization of deferred

 compensation on stock options ..........          --             --             --         17,782               --
Net loss ................................          --             --             --             --
                                              -------    -----------    -----------     ----------
Balance, December 31, 1998 ..............     567,800       (119,000)       583,865        (16,218)              --
Conversion -- non-voting shares to
 voting .................................          --             --             --             --
Issuance of common stock ................          --             --        101,914        (87,014)              --
Share options exercised .................          --             --         26,305             --
Issuance of stock options ...............          --             --        435,161       (435,161)              --
Amortization of deferred
 compensation on stock options
 and restricted stock ...................          --             --             --        138,185               --
Accretion of transaction costs on
 redeemable convertible preferred
 stock ..................................          --             --         (8,139)            --               --
Accrual of dividend on redeemable
 convertible preferred stock ............          --             --       (168,300)            --               --
Net loss ................................          --             --             --             --
                                              -------    -----------    -----------     ----------
Balance, December 31, 1999 ..............     567,800       (119,000)       970,806       (400,208)              --
Share options exercised .................          --             --        972,060             --          (13,436)
Issuance of stock options ...............          --             --        712,803       (712,803)
Issuance of common stock ................                                 3,549,454             --       (1,000,000)
Issuance of warrants ....................                                    13,492             --               --
Adjustments to deferred
 compensation for variable stock
 options and restricted stock ...........          --             --        328,835       (328,835)              --
Amortization of deferred
 compensation on stock options
 and restricted stock ...................          --             --             --        980,112               --
Accretion of transaction costs on
 redeemable convertible preferred
 stock ..................................          --             --         (8,138)            --               --
Accrual of dividend on redeemable
 convertible preferred stock ............          --             --       (160,002)            --               --
Retirement of treasury stock ............    (567,800)       119,000       (118,433)
Net loss ................................          --             --             --             --
                                             --------    -----------    -----------     ----------
Balance, June 30, 2000 (unaudited) ......          --             --      6,260,877       (461,734)      (1,013,436)
Pro forma conversion of redeemable
 convertible preferred stock to
 common stock (unaudited) ...............          --             --     14,257,997             --               --
Pro forma conversion of nonvoting
 to voting common stock
 (unaudited) ............................          --             --             --             --               --
                                             --------    -----------    -----------     ----------     ------------
Pro forma balance, June 30, 2000
 (unaudited) ............................          --    $        --    $20,518,874     $ (461,734)    $ (1,013,436)
                                             ========    ===========    ===========     ==========     ============



<CAPTION>
                                             ACCUMULATED
                                               DEFICIT          TOTAL
                                          ---------------- ---------------
<S>                                       <C>              <C>
Balance, January 1, 1997 ................   $   (157,295)   $     76,237
Purchase of treasury stock ..............             --        (119,000)
Issuance of stock options ...............             --         316,234
Net loss ................................       (134,080)       (134,080)
                                            ------------    ------------
Balance, December 31, 1997 ..............       (291,375)        139,391
Share options exercised .................             --           4,401
Issuance of stock options ...............             --              --
Amortization of deferred

 compensation on stock options ..........             --          17,782
Net loss ................................       (566,754)       (566,754)
                                            ------------    ------------
Balance, December 31, 1998 ..............       (858,129)       (405,180)
Conversion -- non-voting shares to
 voting .................................             --              --
Issuance of common stock ................             --          15,000
Share options exercised .................             --          26,442
Issuance of stock options ...............             --              --
Amortization of deferred
 compensation on stock options
 and restricted stock ...................             --         138,185
Accretion of transaction costs on
 redeemable convertible preferred
 stock ..................................             --          (8,139)
Accrual of dividend on redeemable
 convertible preferred stock ............             --        (168,300)
Net loss ................................     (1,315,015)     (1,315,015)
                                            ------------    ------------
Balance, December 31, 1999 ..............     (2,173,144)     (1,717,007)
Share options exercised .................             --         961,881
Issuance of stock options ...............             --              --
Issuance of common stock ................                      2,550,011
Issuance of warrants ....................                         13,492
Adjustments to deferred
 compensation for variable stock
 options and restricted stock ...........             --              --
Amortization of deferred
 compensation on stock options
 and restricted stock ...................             --         980,112
Accretion of transaction costs on
 redeemable convertible preferred
 stock ..................................             --          (8,138)
Accrual of dividend on redeemable
 convertible preferred stock ............             --        (160,002)
Retirement of treasury stock ............                             --
Net loss ................................     (6,069,055)     (6,069,055)
                                            ------------    ------------
Balance, June 30, 2000 (unaudited) ......     (8,242,199)     (3,448,706)
Pro forma conversion of redeemable
 convertible preferred stock to
 common stock (unaudited) ...............             --      14,263,194
Pro forma conversion of nonvoting
 to voting common stock
 (unaudited) ............................             --              --
                                            ------------    ------------
Pro forma balance, June 30, 2000
 (unaudited) ............................   $ (8,242,199)   $ 10,814,488
                                            ============    ============
</TABLE>

                See notes to consolidated financial statements.

                                       F-6

<PAGE>

                                INFORMAX, INC.

                      CONSOLIDATED STATEMENTS OF CASH FLOWS

<TABLE>
<CAPTION>

                                                                                                 SIX MONTHS ENDED
                                                      YEAR ENDED DECEMBER 31,                        JUNE 30,
                                           ---------------------------------------------- ------------------------------
                                                1997           1998            1999            1999           2000
                                           -------------- -------------- ---------------- ------------- ----------------
                                                                                           (UNAUDITED)     (UNAUDITED)
<S>                                        <C>            <C>            <C>              <C>           <C>
Cash flow from operating activities:
 Net loss ................................   $ (134,080)   $   (566,754)   $ (1,315,015)   $  (81,589)    $ (6,069,055)
 Adjustments to reconcile net loss
   to net cash provided by (used
   in) operating activities:
   Depreciation expense ..................       17,945          93,809         272,548        88,872          342,984
   Loss on sale of furniture and
    equipment ............................           --              --           9,840            --            4,312
   Expense related to stock
    options, restricted stock and
    warrants .............................      316,234          17,782         138,185        26,391          993,513
   Deferred income tax benefit ...........     (254,403)       (391,291)       (623,223)      (23,320)              --
   Changes in other assets:
    (Increase) decrease in
      accounts receivable ................     (165,251)     (1,184,462)     (1,090,157)      567,767       (1,025,538)
    (Increase) decrease in income
      tax receivable .....................           --              --        (122,446)           --          122,446
    (Increase) decrease in prepaid
      expenses ...........................           --              --        (222,473)      (49,910)          30,316
    Increase in other current
      assets .............................       (8,073)         (1,362)        (23,762)      (14,551)          (2,535)
    Increase in deposits .................       (4,752)         (4,046)        (57,113)      (39,474)         (13,522)
   Changes in other liabilities:
    Increase in accounts payable .........       53,158         346,669          11,020       324,407          698,511
    Increase (decrease) in accrued
      liabilities ........................      117,483         163,647         591,153      (169,417)        (448,637)
    Increase (decrease) in income
      tax payable ........................      125,638          15,307        (151,296)      (98,355)              --
    Increase (decrease) in billings
      in excess of cost on
      government contracts ...............        8,578          56,218         (79,796)       33,345               --
    Increase (decrease) in
      deferred revenue ...................      350,900       1,388,375          72,395      (290,546)       1,799,059
                                             ----------    ------------    ------------    ----------     ------------
      Cash provided by (used in)
       operating activities ..............      423,377         (66,108)     (2,590,140)      273,620       (3,568,146)
                                             ----------    ------------    ------------    ----------     ------------
Cash flow from investing activities:
 Purchase of furniture and
   equipment .............................       (5,437)        (71,505)     (1,342,908)     (272,227)      (1,306,476)
 Proceeds from sale of furniture
   and equipment .........................           --              --           9,621            --            3,629
 Increase in shareholder note
   receivable ............................           --              --         (65,000)      (65,000)              --
 Repayment of shareholder note
   receivable ............................           --              --              --            --           65,000
                                             ----------    ------------    ------------    ----------     ------------
      Cash used in investing
       activities ........................       (5,437)        (71,505)     (1,398,287)     (337,227)      (1,237,847)
                                             ----------    ------------    ------------    ----------     ------------
 </TABLE>

                                       F-7

<PAGE>

<TABLE>
<CAPTION>

                                                                                                      SIX MONTHS ENDED
                                                         YEAR ENDED DECEMBER 31,                          JUNE 30,
                                              ----------------------------------------------   -------------------------------
                                                  1997            1998             1999             1999             2000
                                              ------------   --------------   --------------   --------------   --------------
                                                                                                 (UNAUDITED)      (UNAUDITED)
<S>                                           <C>            <C>              <C>              <C>              <C>
Cash flow from financing activities:
 Repayments on capital lease
   obligations ............................      (16,915)         (88,390)        (105,532)         (42,711)         (59,813)
 Proceeds from line of credit .............           --          140,509          618,239          368,239        1,500,000
 Repayments on line of credit .............           --               --         (268,239)        (200,000)        (400,000)
 Proceeds from notes payable ..............           --           29,415           92,363           15,193               --
 Proceeds from equipment loan
   facility ...............................           --               --          960,547               --        1,135,000
 Repayment of equipment loan
   facility ...............................           --               --               --               --         (189,574)
 Repayments on notes payable ..............       (5,000)         (35,000)        (156,778)         (79,608)              --
 Purchase of treasury stock ...............      (49,000)              --               --               --               --
 Closing costs for Series A
   redeemable convertible
   preferred stock ........................           --               --          (81,385)         (81,385)              --
 Proceeds from sale of Series A
   redeemable convertible
   preferred stock ........................           --               --        4,000,000        4,000,000               --
 Proceeds from issuance of common
   stock ..................................           --               --           15,000              320        2,550,014
 Proceeds from issuance of warrants........           --               --               --               --               90
 Proceeds from share options
   exercised ..............................           --            4,401           17,480               --          961,880
                                                 -------          -------        ---------        ---------        ---------
      Cash (used in) provided by
       financing activities ...............      (70,915)          50,935        5,091,695        3,980,048        5,497,597
                                                 -------          -------        ---------        ---------        ---------
Net increase (decrease) in cash and
 cash equivalents .........................      347,025          (86,678)       1,103,268        3,916,441          691,604
Beginning cash and cash equivalents .......       35,322          382,347          295,669          295,669        1,398,937
                                                 -------          -------        ---------        ---------        ---------
Ending cash and cash equivalents ..........    $ 382,347       $  295,669       $1,398,937       $4,212,110       $2,090,541
                                               =========       ==========       ==========       ==========       ==========
Supplemental information on noncash
 investing and financing transactions:
 Purchases of equipment through
   capital lease obligations:
 Purchase of equipment ....................    $ (97,071)      $ (296,814)      $  (14,581)      $  (14,581)      $       --
 Increase in capital lease obligations.....       97,071          296,814           14,581           14,581               --
                                               ---------       ----------       ----------       ----------       ----------
                                               $      --       $       --       $       --       $       --       $       --
                                               =========       ==========       ==========       ==========       ==========
 Purchase of treasury stock through note payable:

 Increase in notes payable ................    $  70,000       $       --       $       --       $       --       $       --
 Increase in treasury stock ...............      (70,000)              --               --               --               --
                                               ---------       ----------       ----------       ----------       ----------
                                               $      --       $       --       $       --       $       --       $       --
                                               =========       ==========       ==========       ==========       ==========
 Retirement of treasury stock:
 Increase in additional paid in
   capital ................................    $      --       $       --       $       --       $       --       $  118,433
 Increase in common stock .................           --               --               --               --              567
 Decrease in treasury stock ...............           --               --               --               --         (119,000)
                                               ---------       ----------       ----------       ----------       ----------
                                               $      --       $       --       $       --       $       --       $       --
                                               =========       ==========       ==========       ==========       ==========
</TABLE>

                                       F-8

<PAGE>

<TABLE>
<CAPTION>

                                                                                              SIX MONTHS ENDED
                                                     YEAR ENDED DECEMBER 31,                      JUNE 30,
                                              -------------------------------------   --------------------------------
                                                 1997         1998          1999           1999             2000
                                              ----------   ----------   -----------   -------------   ----------------
                                                                                       (UNAUDITED)       (UNAUDITED)
<S>                                           <C>          <C>          <C>           <C>             <C>
Deferral of offering costs:
Increase in deferred offering costs .......    $    --      $    --      $     --        $    --        $    373,740
Increase in accounts payable ..............         --           --            --             --            (373,740)
                                               -------      -------      --------        -------        ------------
                                               $    --      $    --      $     --        $    --        $         --
                                               =======      =======      ========        =======        ============
Stock purchase through subscription receivable:
Increase in subscription receivable .......    $    --      $    --      $     --        $    --        $ (1,013,436)
Increase in additional paid-in capital.....         --           --            --             --           1,013,234
Increase in common stock ..................         --           --            --             --                 202
                                               -------      -------      --------        -------        ------------
                                               $    --      $    --      $     --        $    --        $         --
                                               =======      =======      ========        =======        ============
Supplemental cash flow information:
 Cash paid for income taxes ...............    $    --      $    --      $151,296        $    --        $         --
                                               =======      =======      ========        =======        ============
 Cash paid for interest ...................    $18,523      $59,910      $ 83,995        $32,927        $    119,229
                                               =======      =======      ========        =======        ============
 </TABLE>

                See notes to consolidated financial statements.

                                       F-9

<PAGE>

                               INFORMAX, INC.
                  NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


1.   NATURE OF THE BUSINESS

InforMax  is a global  provider  of  bioinformatic  software  solutions  for the
analysis and  interpretation of genomic,  proteomic and other biomolecular data.
Bioinformatic   software  is  a  key  enabling   technology,   representing  the
convergence   of  molecular   biology,   information   technology  and  Internet
communications.  Bioinformatic  software,  combined  with  automated  laboratory
research technologies, enables researchers across the numerous disciplines using
a data driven,  genomic  approach to  biological  discovery  to achieve  greater
efficiency,  productivity  and  collaboration  in their research.  The Company's
bioinformatic  software  solutions make it possible for  researchers  within and
across organizations to efficiently organize,  integrate, analyze, interpret and
visualize  diverse and rapidly growing  volumes of genomic,  proteomic and other
biomolecular data. The Company also provides  technology  consulting services to
the National Center for Biotechnology Information (NCBI) under subcontracts.

InforMax,  Inc. was incorporated in Delaware in May 1990 and its  majority-owned
subsidiary, InforModus SARL, was organized under the tax laws of France in 1997.
The Company is  headquartered in Rockville,  Maryland,  and has sales offices in
Rockville,  Maryland; Annapolis,  Maryland; San Francisco,  California;  Denver,
Colorado; and Oxford, England.

2.   SIGNIFICANT ACCOUNTING POLICIES

Principles of Consolidation - The accompanying consolidated financial statements
include the accounts of InforMax,  Inc.  and its 74%  ownership  interest in its
subsidiary.  The minority interest is immaterial in relation to the consolidated
financial  statements.  All significant  intercompany  accounts and transactions
have been eliminated.

Basis of Accounting - The accompanying  financial  statements have been prepared
on the accrual basis of accounting and in conformity with accounting  principles
generally accepted in the United States of America.

Revenue Recognition - The Company derives revenue principally from four sources:
software licensing, maintenance fees, training and consulting services primarily
under government contracts.  Software licensing,  maintenance fees, and training
are  presented  as software  license and  customer  support on the  Consolidated
Statements of  Operations.  Consulting  services are  presented as  professional
services on the Consolidated Statements of Operations.

The Company  recognizes  software  license  revenue  based on the  provisions of
Statement of Position ("SOP") No. 97-2, Software Revenue Recognition (as amended
by SOP No. 98-4 and SOP No.  98-9).  Software  license  fees are  recognized  as
revenue upon the customer's execution of a non-cancelable  license agreement and
the Company's  delivery of the software,  provided that the license fee is fixed
and  determinable,  collectibility  is  probable,  and no  customization  of the
software is required.  In connection  with software  licenses,  the Company also
enters  into  maintenance  contracts  that  provide  for  technical  support and
periodic unspecified upgrades.

During 1997 and 1998,  maintenance  revenue  was  recognized  together  with the
initial  licensing  fee upon  delivery of the software when all of the following
were met: (1) the maintenance  fee was included with the initial  licensing fee,
(2) the  maintenance  revenue to be recognized was for one year or less, (3) the
estimated   cost  of   providing   maintenance   during  the   arrangement   was
insignificant,  and (4) any unspecified upgrades were expected to be minimal. In
circumstances  where  these  criteria  were not met and  where  fair  value  for
undelivered  elements  of a  multiple  element  contract  are not  determinable,
revenue  on the  contract  is  entirely  deferred  until  either  fair  value is
determinable  or when all elements are  delivered.  If the Company was unable to
establish  vendor specific  objective  evidence of fair value on the undelivered
elements and the only  undelivered  element was maintenance  then all revenue is
recognized ratably over the maintenance period.

                                      F-10

<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


Due to the  introduction  of new  modules,  product  enhancements,  and  product
versions,  the Company increased its maintenance support staff and, as a result,
the estimated  cost of providing  maintenance  services  (post-contract  support
services) to customers was no longer deemed insignificant.  Therefore, beginning
in January 1999, revenues from all software maintenance contracts were unbundled
from software  license  based upon vendor  specific  objective  evidence of fair
value and was recognized  ratably over the maintenance  period.  Vendor specific
objective evidence of fair value for maintenance  contracts is determined by the
list price  established  by  management  with the  relevant  authority or by the
renewal rate specified in the contract.  The Company uses the residual method to
recognize revenue on delivered  elements when vendor specific objective evidence
of fair value has been determined for all undelivered  elements.  Discounts,  if
any,  are  applied to the  delivered  elements if the  residual  method is used.
Amounts  received  in advance of the  delivery of  products  or  performance  of
services are classified as deferred revenues.

Training  is  provided  on a daily  fee basis  with  revenue  recognized  as the
services are provided.

Consulting services other than under government contracts are provided on a time
and material basis with revenue recognized as the services are provided.

During 1997 and 1998, the Company's consulting services revenue under government
contracts related to services provided under a time and material subcontract and
a   cost-plus-fixed-fee   subcontract.   During  1999  the   cost-plus-fixed-fee
subcontract  was  converted  at the  time  of  renewal  to a time  and  material
contract.  Revenue under the time and material  subcontracts is recognized based
on  contractual   rates  as  the  services  are  provided.   Revenue  under  the
cost-plus-fixed-fee   subcontract  was  recognized  as  recoverable  costs  were
incurred, including a proportionate amount of the fixed fee. Billings under cost
reimbursement  contracts are based on provisional  rates. The amount reported in
the  accompanying  financial  statements  as billings in excess of costs results
from the difference  between the  provisional  rates billed and the actual rates
incurred.

Property  and  Equipment  - Property  and  equipment  are  stated at cost,  less
accumulated   depreciation  and  amortization.   Depreciation  on  property  and
equipment is computed on a straight-line  basis over the estimated  useful lives
of the  assets  ranging  from  three to ten years.  Leasehold  improvements  are
depreciated  over the shorter of the estimated  useful life of the assets or the
terms of the related lease.  Repairs and  maintenance  are expensed as incurred;
major improvements and betterments are capitalized.

Software  Development  Costs -  Development  costs  incurred in the research and
development  of new software  products  and  enhancements  to existing  software
products  are  expensed as incurred  until  technological  feasibility  has been
established.  The Company considers technological  feasibility to be established
when all planning, designing, coding and testing has been completed according to
design specifications. After the technological feasibility has been established,
any  additional  costs would be  capitalized  in  accordance  with  Statement of
Financial  Accounting  Standards No. 86,  "Accounting  for the Costs of Computer
Software to be Sold, Leased or Otherwise  Marketed."  Through December 31, 1999,
software  development has been  substantially  completed  concurrently  with the
establishment of technological feasibility,  and accordingly, no costs have been
capitalized to date.

Income Taxes - The income tax provision  includes income taxes currently payable
plus the net change  during  the year in  deferred  tax  assets or  liabilities.
Deferred tax assets and liabilities reflect the differences between the carrying
value in conformity with accounting  principles generally accepted in the United
States of America  and tax values of assets and  liabilities  using  enacted tax
rates for the period in which the differences are expected to reverse.

Cash and Cash Equivalents - Cash and cash equivalents  consist of cash and money
market  accounts.  For  purposes of the  statement  of cash  flows,  the Company
considers all highly liquid debt instruments  with original  maturities of three
months or less to be cash equivalents.


                                      F-11

<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


Concentration of Credit Risk - Financial  instruments  that potentially  subject
the Company to a concentration of credit risks consist principally of cash, cash
equivalents,  and accounts  receivable.  The Company  generally does not require
collateral  on  accounts  receivable  as  the  majority  of  its  customers  are
well-established companies, colleges, universities and government entities.

The Company  maintains  its cash and cash  equivalents  in bank accounts that at
times may exceed  federally  insured  limits.  At  December  31,  1998 and 1999,
balances of approximately $48,000 and $1,436,000,  respectively,  were in excess
of the federally insured limit of $100,000.  The Company has not experienced any
losses in these  accounts  and  believes  it is not  exposed to any  significant
credit risk.

Stock-Based  Compensation - In February 1999, the Board of Directors  instituted
an Equity  Incentive  Plan (the  Plan)  intended  to  qualify  as such under the
provisions of Section 422 of the Internal  Revenue Code of 1986, as amended.  In
addition, the Company has issued nonqualified stock options.

The Company follows Financial  Accounting Standards Board Statement of Financial
Accounting  Standards No. 123,  "Accounting for Stock-Based  Compensation" (SFAS
No. 123). In  accounting  for stock  options,  as permitted by SFAS No. 123, the
Company  accounts for  stock-based  compensation to employees in accordance with
Accounting  Principles Board (APB) Opinion No. 25, and  accordingly,  recognizes
compensation  expense for fixed stock option grants only when the exercise price
is less than the fair value of the  shares on the date of the  grant.  Pro forma
information is provided for employee stock option grants made in 1997, 1998, and
1999 as if the fair value based method defined in SFAS No. 123 had been applied.

Evaluation of Long-lived Assets - The Company evaluates the potential impairment
of long-lived  assets based upon projections of undiscounted cash flows whenever
events or changes in circumstances indicate that the carrying amount of an asset
may not be fully recoverable.  Management believes no impairment of these assets
exists at December 31, 1998 and 1999.

Fair Value of Financial  Instruments  - The following  disclosures  of estimated
fair value were determined by management using available market  information and
appropriate valuation methodologies.

The  fair  values  of  the  Company's  financial  instruments,   including  cash
equivalents,  accounts receivable,  accounts payable, accrued expenses, lines of
credit, notes payable and long-term debt approximate their carrying values.

Disclosure  about fair values of  financial  instruments  is based on  pertinent
information  available to management as of December 31, 1998 and 1999.  Although
management  is not aware of any  factors  that  would  significantly  affect the
reasonable  fair  value  amounts,  current  estimates  of fair  value may differ
significantly from the amounts presented herein.

Advertising  - The Company  expenses all  advertising  costs as incurred.  Total
advertising  expense  was  $3,157,  $83,419  and  $612,196  for the years  ended
December 31, 1997, 1998, and 1999, respectively.

Estimates  and  Assumptions  -  The  preparation  of  financial   statements  in
conformity with accounting principles generally accepted in the United States of
America requires  management to make estimates and assumptions.  These estimates
and  assumptions  affect the  reported  amounts of assets and  liabilities,  the
disclosure of  contingent  assets and  liabilities  at the date of the financial
statements,  as well as the reported amounts of revenues and expenses during the
year. Actual results could vary from the estimates that were used.

Redeemable  Convertible  Preferred Stock - The Company  accretes the increase in
the  redemption  value of its Series A Redeemable  Convertible  Preferred  Stock
through a charge to additional  paid-in capital based upon the redemption  dates
prescribed in the Series A Preferred  Stock  Agreement.  The period of accretion
begins on the June 1999 issue date and ends on the prescribed  redemption  date,
which is the fifth anniversary of the original issue date.

                                      F-12

<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


Comprehensive Income - The Company has no elements of comprehensive income other
than net loss.

Net Loss Per  Share - Basic  net loss per  share  has been  computed  using  the
weighted average number of common shares  outstanding  during the year:  diluted
net loss per share  includes  dilutive stock options and  convertible  preferred
stock.  Due to net  operating  losses for each of the three  years in the period
ended December 31, 1999, the stock options and  convertible  preferred stock are
considered antidilutive.

Unaudited Interim Financial  Statements -- The accompanying  unaudited condensed
consolidated   financial  statements  have  been  prepared  in  accordance  with
generally accepted accounting principles in the United States of America. In the
opinion of management,  all  adjustments,  consisting  only of normal  recurring
adjustments  considered  necessary for a fair presentation,  have been included.
Operating  results for any period are not necessarily  indicative of the results
for any other period or for the full year.

Unaudited Pro forma  Presentation - Under the terms of the Company's  agreements
with the holders of the Series A and Series B Redeemable  Convertible  Preferred
Stock  (see  Notes 7 and 16),  all of such  preferred  stock  will be  converted
automatically  into  shares of common  stock upon the  closing of the  Company's
initial public  offering.  The unaudited pro forma balance sheet  information at
June 30, 2000 reflects the issuance of Series B Redeemable Convertible Preferred
Stock  and  conversion  of the  Series  A and  Series B  Redeemable  Convertible
Preferred  Stock  into  5,197,060  shares of common  stock as if the  conversion
occurred on June 30, 2000.  In addition,  the  unaudited pro forma balance sheet
information  at  June  30,  2000  reflects  the  conversion  of the  outstanding
nonvoting  common stock into shares of voting common stock as if the  conversion
occurred on June 30, 2000.

Reclassifications - Certain  reclassifications  have been made to the prior-year
financial statements to conform to current-year presentation.

New Accounting Pronouncements - In June 1998, the Financial Accounting Standards
Board  issued  Statement  of  Financial  Accounting  Standards  (SFAS) No.  133,
"Accounting   for  Derivative   Instruments  and  Hedging   Activities,"   which
establishes  accounting and reporting  standards for derivative  instruments and
hedging activities.  As amended by Statement of Financial  Accounting  Standards
No. 137,  this  standard  will be effective for the Company for fiscal years and
quarters  beginning  after  December  31,  2000,  and  requires  that an  entity
recognize all  derivatives  as either assets or  liabilities in the statement of
financial  position and measure those instruments at fair value. The Company has
not  completed  the  process of  evaluating  the impact  that will  result  from
adopting SFAS No. 133. The Company is therefore  unable to predict the potential
impact  that  adopting  SFAS No.  133 will have on its  financial  position  and
results of operations when such statement is adopted.

In December  1999, the  Securities  and Exchange  Commission  (SEC) issued Staff
Accounting   Bulletin   (SAB)  No.  101,   "Revenue   Recognition  in  Financial
Statements".  This SAB expresses the SEC's views on applying  generally accepted
accounting  principles  to revenue  recognition  in  financial  statements.  The
application  of this  SAB  will  not have a  material  impact  on the  Company's
financial statements, however, certain SEC staff interpretations of the SAB have
not been published and may have an effect on the applicability of the SAB to the
consolidated financial statements.

In  March  2000,   the  Financial   Accounting   Standards   Board  issued  FASB
Interpretation  No. 44,  "Accounting  for Certain  Transactions  Involving Stock
Compensation,  an  Interpretation  of APB Opinion No. 25." With the exception of
certain  provisions which require earlier  application,  this  interpretation is
effective for all  applicable  transactions  beginning July 1, 2000. The Company
does not expect that the  adoption of this  Interpretation  will have a material
impact on its financial statements.


                                      F-13

<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999

3. ACCRUED LIABILITIES

Accrued liabilities consisted of the following as of December 31, 1998 and 1999:

<TABLE>
<CAPTION>
                                                          1998          1999
                                                       ----------   -----------
<S>                                                    <C>          <C>
   Accrued bonuses .................................    $ 85,000     $182,250
   Accrued interest ................................          --        2,543
   Accrued commissions .............................     224,070      369,105
   Accrued litigation liability (Note 14) ..........          --      228,600
   Other ...........................................      32,902      150,627
                                                        --------     --------
     Total .........................................    $341,972     $933,125
                                                        ========     ========
</TABLE>

4. INCOME TAXES

The  components of the benefit for income taxes for the years ended December 31,
1997, 1998, and 1999, were as follows:

<TABLE>
<CAPTION>
                                                          1997            1998            1999
                                                     -------------   -------------   -------------
<S>                                                  <C>             <C>             <C>
   Current provision (benefit):
     Federal .....................................    $  107,599      $       --      $  (86,495)
     State .......................................        28,580              --         (16,625)
                                                      ----------      ----------      ----------
       Total current provision (benefit) .........       136,179              --        (103,120)
                                                      ----------      ----------      ----------
    Deferred benefit:
     Federal .....................................      (208,291)       (324,627)       (504,380)
     State .......................................       (46,112)        (66,664)       (118,843)
                                                      ----------      ----------      ----------
       Total deferred benefit ....................      (254,403)       (391,291)       (623,223)
                                                      ----------      ----------      ----------
       Total benefit for income taxes ............    $ (118,224)     $ (391,291)     $ (726,343)
                                                      ==========      ==========      ==========
</TABLE>

At December 31, 1998 and 1999,  respectively,  the  components  of the Company's
deferred tax assets and deferred tax liabilities were as follows:

<TABLE>
<CAPTION>
                                                            1998           1999
                                                        -----------   -------------
<S>                                                     <C>           <C>
   Deferred tax assets:
     Deferred revenue ...............................    $449,643      $  699,667
     Compensation relating to stock options .........      64,341          84,838
     Allowance for doubtful accounts ................       5,793           5,793
     Restricted stock ...............................          --          12,530
     Accrued commissions ............................          --          17,909
     Net operating loss .............................     110,450         493,401
     Research and development tax credit ............      23,500              --
                                                         --------      ----------
       Total deferred tax assets ....................     653,727       1,314,138
                                                         --------      ----------
    Deferred tax liabilities:
     Accelerated depreciation .......................      (8,033)        (36,259)
                                                         --------      ----------
       Total deferred tax liabilities ...............      (8,033)        (36,259)
                                                         --------      ----------
       Net deferred tax assets ......................    $645,694      $1,277,879
                                                         ========      ==========
</TABLE>

At December 31, 1999, the Company had a net federal  operating loss carryforward
of approximately $1,277,600,  expiring in 2019. The net operating loss generated
in 1998 was carried back to 1996 and 1997  resulting in an income tax receivable
of $122,446 as of December 31, 1999. The provision for

                                      F-14
<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999

income taxes  differs from the amount  computed by applying the  statutory  U.S.
Federal income taxes as a result of the following:

<TABLE>
<CAPTION>
                                                                   1997             1998             1999
                                                              --------------   --------------   --------------
<S>                                                           <C>              <C>              <C>
   Statutory U.S. Federal rate ............................        (34.00)%         (34.00)%         (34.00)%

   (Increase) decrease in taxes resulting from: ...........
     State income taxes - net of Federal benefit ..........        ( 4.62)          ( 4.62)          ( 4.38)
     R&D credits ..........................................        ( 8.52)          ( 2.45)              --
     Other ................................................          0.28             0.23             2.80
                                                                   ------           ------           ------
    Effective tax rate ....................................        (46.86)%         (40.84)%         (35.58)%
                                                                   ======           ======           ======
</TABLE>

5.   STOCKHOLDERS' EQUITY (DEFICIT)

Common  Stock - The  Company  has two  classes of common  stock.  These  classes
include a voting class of common stock (Voting  Shares) and a nonvoting class of
common stock (Nonvoting  Shares).  Voting shares have voting rights with respect
to all matters customarily  reserved to holders of a corporation's  common stock
under the Delaware  General  Corporation Law. Except with respect to the lack of
voting  rights,  Nonvoting  Shares have all of the rights and  interests  of the
Voting Shares.  With respect to the voting rights of the Nonvoting Shares,  such
shares  are  only  entitled  to  vote  on  amendments  to  the   Certificate  of
Incorporation  of the Company that would: (a) increase or decrease the number of
authorized  nonvoting  shares,  (b)  increase or  decrease  the par value of the
nonvoting  shares,  or (c) alter or change the powers,  preferences,  or special
rights of the Nonvoting Shares. See Note 16.

In February 1999, the Board of Directors  approved a 100:1 stock split of all of
the  shares of the  common  stock of the  Company  issued  and  outstanding.  In
connection with the stock split, the Board of Directors approved the increase in
the number of  authorized  shares of voting  common stock to  1,595,455  and the
increase  in the  number of  authorized  shares  of  nonvoting  common  stock to
14,931,864.  Further,  the Board of  Directors  approved the exchange of 590,178
shares of nonvoting  common stock for 590,178  shares of voting  common stock by
the President/Chief  Executive Officer.  Shares issued and outstanding have been
adjusted  retroactively  for all  periods  presented  to reflect  that change in
capital structure.

In 1999, the Board of Directors  granted  100,200 shares of restricted  stock to
two  consultants  of the Company.  The  restricted  stock vests over a four-year
period and is subject to service and  performance  requirements.  At the time of
grant, the restricted stock and deferred  compensation  relating to the issuance
of the restricted stock was recorded based on the estimated fair market value of
the Company's common stock. The Company recognizes  compensation expense related
to the  restricted  stock on a monthly  basis as the stock is earned  and vests,
based  upon the  difference  between  the  price  paid at the  original  date of
issuance and the  estimated  fair market value of the common stock at the end of
each subsequent  month.  Deferred  compensation  expense is adjusted  monthly to
reflect  the amount of  compensation  expense  recognized  and the change in the
estimated  fair market value of the  Company's  common stock with respect to the
unvested restricted stock. In relation to the issuance of this restricted stock,
the Company  received $15,000 in cash and recorded  compensation  expense in the
amount  of  $32,444  during  the year  ended  December  31,  1999  and  deferred
compensation  of $54,570  was  included in  stockholders'  equity  (deficit)  at
December 31, 1999.

Stock Options - During 1997, the Company granted  1,569,967  nonqualified  stock
options to employees and one nonemployee,  all such options vesting immediately.
For services rendered, the non-employee received a total of 167 options having a
fair value based upon the


                                      F-15

<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


Black-Scholes  pricing  model of  approximately  $3,400.  The  Company  recorded
compensation  expense in the amount of $316,234  during the year ended  December
31, 1997 in relation to the options issued to the one nonemployee and employees.
In 1998, the Company granted 167,000  nonqualified stock options to an employee,
originally  vesting over a four-year period.  The Company recorded  compensation
expense relating to 1998 options in the amount of $17,782 and $16,218 during the
years ended December 31, 1998 and 1999,  respectively and deferred  compensation
of $16,218 and $-0- was included in  stockholders'  equity (deficit) at December
31, 1998 and 1999, respectively.

On February 10, 1999, the Board of Directors also instituted an equity incentive
compensation  plan (the Plan).  The Plan provides for up to 5,344,000  shares of
common stock of the Company for the granting of  restricted  stock and incentive
stock  options to purchase  common  stock.  The exercise  price per share for an
incentive  stock  option  must be equal to or greater  than the  estimated  fair
market value,  as determined by the Board committee  administering  the Plan, on
the date of grant.  In  connection  with the issuance of the Series A Redeemable
Convertible  Preferred  Stock,  a limit was placed on the number of options that
could be granted  under the Plan.  At December 31,  1999,  the total shares that
could be issued under the Plan without further approval by the Series A designee
to the Board was 4,854,783.

Pursuant to the terms of the key agreement underlying the Company's relationship
with one of the Company's key investors,  unless otherwise approved by the Board
of Directors,  all stock options and other stock equivalents  issued pursuant to
agreements  executed by the Company to employees,  Directors,  consultants,  and
other service providers shall be subject to vesting as follows:  (a) twenty-five
percent  (25%) of such stock  shall vest at the end of the first year  following
the earlier of the date of issuance or such person's service  commencement  date
with the Company,  and (b) seventy-five  (75%) of such stock shall vest over the
remaining three year period  subsquent to the end of the first year described in
(a).

During 1999, the Company granted  3,818,804  stock options to employees.  Out of
the total stock option  grants,  746,698  options  vested  immediately,  111,624
options were  forfeited  or  cancelled,  with the  remaining  2,960,480  options
vesting over a four-year period.

In February 1999, the Board of Directors  also granted  10,938,333  nonqualified
stock options to the three  employees  who were  founders of the Company.  These
stock options vested  immediately.  At grant date, the option price was equal to
the fair value of the Company's common stock.

During 1999, the Company also granted 175,350 stock options under three separate
nonqualified  stock  option  agreements,  one of  which  is with a non  employee
director,  the other  two were  with non  employee  advisors.  The non  employee
director  compensation  expense was determined based upon the difference between
the exercise  price and the  estimated  fair market value of the common stock at
the date of grant. The Company  recognized  compensation  expense related to the
non-employee  advisors  nonqualified  stock  options  on a monthly  basis as the
options  are earned and vest,  based upon the fair value of the  options  earned
calculated using the Black-Scholes  pricing model. Deferred compensation expense
is adjusted monthly to reflect the amount of compensation expense recognized and
the  change in the  estimated  fair  value of the  unvested  nonqualified  stock
options. Changes in the fair value of the unvested nonqualified stock options


                                      F-16

<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999

could result in an increase in future compensation changes. All of these options
were granted for a ten-year  period and vest over either  three,  four,  or five
years which  coincides with the period of  performance.  The number of shares to
vest in each year is as follows:

<TABLE>
<S>                 <C>
   1999 .........   34,095
   2000 .........   45,364
   2001 .........   42,585
   2002 .........   37,735
   2003 .........   10,561
   2004 .........    5,010
</TABLE>

In relation to the  issuance of the  options to the  nonemployee  director,  the
Company  recorded  compensation  expense in the amount of $1,998 during the year
ended  December  31, 1999 and  deferred  compensation  of $5,502 was included in
stockholders' equity (deficit) at December 31, 1999. In relation to the issuance
of  options  issued  to  the   non-employee   advisors,   the  Company  recorded
compensation expense in the amount of $51,078 during the year ended December 31,
1999 and deferred  compensation of $80,889, was included in stockholders' equity
(deficit) at December 31, 1999.

The Company recorded  compensation  expense relating to employee options granted
during 1999 with exercise  prices below the  estimated  fair market value at the
dates of grant in the amount of $36,447, and deferred compensation in the amount
of $259,247 which was included in stockholders' equity (deficit) at December 31,
1999.

Option transactions were as follows:

<TABLE>
<CAPTION>
                                                                                          WEIGHTED AVERAGE
                                                                            SHARES         EXERCISE PRICE
                                                                        --------------   -----------------
<S>                                                                     <C>              <C>
   Options outstanding, January 1, 1997 .............................        106,880         $  0.006
     Options granted ................................................      1,569,967            0.006
                                                                           ---------
    Options outstanding, December 31, 1997 ..........................      1,676,847            0.006
     Options granted ................................................        167,000            0.006
     Options exercised ..............................................       (734,967)           0.006
                                                                           ---------
    Options outstanding, December 31, 1998 ..........................      1,108,880            0.006
     Options granted ................................................     14,932,487            0.299
     Options forfeited or cancelled .................................       (111,624)           0.299
     Options exercised ..............................................       (136,940)           0.128
                                                                          ----------
    Options outstanding, December 31, 1999 ..........................     15,792,803            0.280
                                                                          ==========
    Options exercisable as of December 31, 1999 .....................     13,175,805            0.277
                                                                          ==========
    Options available for future grant at December 31, 1999 .........        922,154
                                                                          ==========
</TABLE>

At December 31, 1999, options outstanding were as follows:

<TABLE>
<CAPTION>
                                    WEIGHTED AVERAGE
                       NUMBER          REMAINING
EXERCISE PRICE      OUTSTANDING     CONTRACTUAL LIFE
----------------   -------------   -----------------
<S>                <C>             <C>
$  0.006             1,028,720         7.8 years
$  0.299            14,764,082         9.3 years
</TABLE>

The Company has computed the pro forma  disclosures  required under SFAS No. 123
for all stock  options  granted as of December 31,  1997,  1998,  and 1999.  The
Company used the minimum value

                                      F-17

<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


method  permitted by SFAS No. 123 for nonpublic  entities for 1997 and 1998. The
weighted average fair value at the date of grant for options granted during both
1997 and 1998 was  $0.21.  The  weighted  average  exercise  price and  weighted
average fair value at the date of grant for options  granted  during 1999 was as
follows:

<TABLE>
<CAPTION>
                                                     EXERCISE PRICE               EXERCISE PRICE
                                                EQUALS FAIR MARKET VALUE    LESS THAN FAIR MARKET VALUE
                                               --------------------------  ----------------------------
<S>                                            <C>                         <C>
   Weighted average exercise price per share          $     0.299                    $  0.299
   Weighted average fair value per share ....         $     0.299                    $  0.968
   Options granted ..........................          14,171,081                     758,406
</TABLE>

The weighted  average  assumptions  used for options granted during fiscal years
1997, 1998, and 1999 were as follows:

<TABLE>
<CAPTION>
                                           1997         1998         1999
                                        ----------   ----------   ----------
<S>                                     <C>          <C>          <C>
   Risk-free interest rate ..........   6.50%        6.50%        5.20%
   Expected dividend yield ..........   0.00%        0.00%        0.00%
   Expected life ....................   5 years      5 years      4 years
   Volatility factor ................      0%           0%          71%
</TABLE>

The pro forma effects of applying SFAS No. 123 for fiscal years 1997,  1998, and
1999 would be as follows:

<TABLE>
<CAPTION>
                                                            1997             1998              1999
                                                       --------------   --------------   ----------------
<S>                                                    <C>              <C>              <C>
   Pro forma net loss ..............................     $ (138,944)      $ (566,897)      $ (2,265,691)
   Pro forma net loss per share - basic ............     $    (0.04)      $    (0.16)      $      (0.58)
   Pro forma net loss per share - diluted ..........     $    (0.04)      $    (0.16)      $      (0.58)
</TABLE>

6.  NET LOSS PER SHARE

In February 1997, the Financial  Accounting  Standards  Board (FASB) issued SFAS
No. 128,  "Earnings Per Share".  This statement  requires dual  presentation  of
basic and diluted earnings per share on the face of the income statement.  Basic
earnings per share is to be computed by dividing net income  available to common
shareholders by the weighted average number of common shares outstanding for the
period.  Diluted  earnings per share is to reflect the  potential  dilution that
could  occur if  securities  or other  contracts  to issue  common  shares  were
exercised or converted into common shares for all periods presented.

The weighted average number of common shares  outstanding and potential dilutive
shares were  4,799,747,  4,685,323 and 17,261,716  relating to stock options and
redeemable convertible preferred stock in 1997, 1998, and 1999, respectively.

For the years ended December 31, 1997,  1998,  and 1999, the Company  incurred a
net loss;  therefore,  all potential  common shares are antidilutive and are not
included in the calculation of the diluted net loss per common share.

Net loss Per  Share  for the Six  Months  Ended  June 30,  2000  (unaudited)  --
Subsequent to the issuance of the June 30, 2000 unaudited consolidated financial
statements,  management  determined  that a  mathematical  error occurred in the
calculation of weighted  average common shares  outstanding -- basic and diluted
for the six months ended June 30, 2000. As a result, the weighted average common
shares  outstanding  -- basic and diluted for the six months ended June 30, 2000
has been  restated  from  4,202,880 to 5,268,665  and basic and diluted net loss
applicable  per  common  share for the six months  ended June 30,  2000 has been
restated from $1.48 to $1.18.


                                      F-18

<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


7.  REDEEMABLE CONVERTIBLE PREFERRED STOCK

On June 22, 1999, the Company  entered into a Series A Preferred  Stock Purchase
Agreement (the Agreement) with a purchaser. The Company authorized,  issued, and
sold 2,161,265 shares of Series A Redeemable  Convertible  Preferred Stock, $.01
par value,  for  $4,000,000  ($1.85 per share).  Each  outstanding  share of the
Series A  Redeemable  Convertible  Preferred  Stock is entitled to the number of
votes such that the  aggregate  vote of the  holders of the Series A  Redeemable
Convertible  Preferred  Stock is equal to the economic stake such shares have in
the Company at the record date for the determination of shareholders entitled to
vote on such  matters.  The  purchasers  of the Series A Redeemable  Convertible
Preferred   Stock,   voting  as  a  separate  class,   exclusive  of  all  other
stockholders,  are entitled to elect one director of the Company. The holders of
the  Common  Stock,  voting  as  a  separate  class,   exclusive  of  all  other
stockholders,  are entitled to elect four directors. The holders of the Series A
Redeemable  Convertible Preferred Stock and the Voting Common Stock, voting as a
single class,  are entitled to elect one  director.  Such rights with respect to
the election of directors  terminate  upon the  effectiveness  of the  Company's
initial public offering.

The holder of any such shares of Series A Redeemable Convertible Preferred Stock
has the right, at its option at any time, to convert any such shares of Series A
Redeemable  Convertible  Preferred Stock into 1.67 fully paid and  nonassessable
shares of Common Stock  subsequent to the stock split discussed in Note 16. Each
share of Series A Redeemable Convertible Preferred Stock is convertible into the
number of shares of Common  Stock that would  result from  dividing the original
issue price per share ($1.85) of the Series A Redeemable  Convertible  Preferred
Stock by the conversion price for the Series A Redeemable  Convertible Preferred
Stock that is in effect at the time of the  conversion.  The initial  conversion
price for the Series A Redeemable  Convertible  Preferred  Stock is the original
issue  price  for the  Series A  Redeemable  Convertible  Preferred  Stock.  The
conversion price may be adjusted from time to time upon certain conditions, such
as sales of common stock, issuance of options and other common stock events.

The holders of the Series A Redeemable  Convertible Preferred Stock are entitled
to receive,  out of funds legally available when and if declared by the Board of
Directors,  cumulative dividends at the annual dividend rate of $.148 per share.
Upon  any  liquidation,  dissolution,  or  winding  up of the  Company,  whether
voluntary  or  involuntary,  or upon  redemption,  the  holders  of the Series A
Redeemable   Convertible   Preferred  Stock  are  first  entitled,   before  any
distribution  or payment is made with  respect to the Common  Stock or any other
series of capital stock,  to be paid out of available funds and assets an amount
equal  to the  "Original  Issue  Price"  ($1.85)  for each  Series A  Redeemable
Convertible  Preferred  Stock as adjusted for common  stock events plus,  in the
case of each share,  an amount  equal to all accrued  dividends  unpaid  thereon
(whether or not declared) and any other  dividends  declared but unpaid thereon.
The undeclared  dividends are being accreted to the redemption  value.  The 1999
accrued  dividend of $168,300 is presented  on the  Consolidated  Statements  of
Operations as an addition to net loss applicable to common shareholders.

If, at any time,  the  Company  obtains  a firm  commitment-underwritten  public
offering of shares of Common  Stock in which (i) the  aggregate  net proceeds of
such public offering equals or exceeds  $15,000,000 and (ii) the public offering
price per share  equals or exceeds  $3.32 per share  (adjusted  for common stock
event),  then  effective upon closing of the sales of such shares by the Company
pursuant to such public offering,  all outstanding shares of Series A Redeemable
Convertible   Preferred   Stock  will   automatically   convert  to  fully  paid
nonassessable shares of Common Stock.

After June 22, 2004, the fifth anniversary of the original issue, at the written
request of a majority of the then-outstanding holders of the Series A Redeemable
Convertible  Preferred Stock to redeem at least 20% of such shares,  the Company
shall,  within 60 days,  redeem in cash from legally available funds, the number
of shares as requested of the Series A Redeemable

                                      F-19

<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


Convertible  Preferred  Stock.  If the Company  does not have  sufficient  funds
legally  available to make full  payment in cash or if such payment  would cause
the Company to be in  violation  of any  covenants  to lenders or others,  then,
within sixty days, the Company shall redeem one-third of the Series A Redeemable
Convertible Preferred Stock as requested in the redemption notice. An additional
third shall be redeemed one year after the redemption  notice and the last third
shall be  redeemed  two years  after the  redemption  notice.  If the Company is
unable to make full payment pursuant to the above, then the Company shall redeem
the Series A Redeemable  Convertible  Preferred Stock in accordance to a payment
schedule  mutually  agreed to by the  Company  and the  holders  of the Series A
Redeemable Convertible Preferred Stock.

The redemption price for each share of Series A Redeemable Convertible Preferred
Stock  shall be  equal to the  Series A  Liquidation  Preference.  The  Series A
Liquidation  Preference is the Original  Issue Price per share,  as adjusted for
any common stock events,  plus all accrued but unpaid  dividends  whether or not
earned or declared.

The  difference  between  the  carrying  amounts  of  the  Series  A  Redeemable
Convertible  Preferred  Stock  of  $4,095,054  at  December  31,  1999,  and the
redemption amount of $4,168,300,  based upon the liquidation amount,  represents
the cost of issuance, which is being accreted pro rata over the period beginning
on June 22, 1999 issuance  date and ending on the  prescribed  redemption  date,
June 22, 2004.  The 1999  accretion  of $8,139 is presented on the  Consolidated
Statements  of  Operations  as an  addition  to net loss  applicable  to  common
shareholders.

8. LEASE COMMITMENTS

Operating  Leases - The Company  leases its  headquarters  office space under an
operating lease that expires in July 2006. The lease for the headquarters office
space contains an escalation clause that provides for increased rentals based on
an annual escalation of 1.03 times the preceding year's base rent.

As of December 31, 1999, the Company was committed to leases for its other sales
offices with portions of the leases expiring through June 2003.

Total rental  expense under all office leases for fiscal years 1997,  1998,  and
1999 was $61,357,  $117,833, and $320,525,  respectively.  At December 31, 1999,
future  minimum  lease  payments  required  under  noncancelable  leases were as
follows:

<TABLE>
<CAPTION>

YEAR ENDED DECEMBER 31,
-----------------------
<S>                                        <C>
    2000 .................................  $  598,723
    2001 .................................     630,562
    2002 .................................     637,630
    2003 .................................     596,867
    2004 .................................     588,605
    Thereafter ...........................     966,033
                                            ----------
    Total minimum lease payments .........  $4,018,420
                                            ==========
</TABLE>


                                      F-20

<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


Capital Leases - The Company is obligated under capital leases for computers and
other  equipment.  The leases expire at various  dates  through April 2002.  The
following is a summary of assets under capital leases:

<TABLE>
<CAPTION>
                                                                       DECEMBER 31,
                                                               -----------------------------
                                                                    1998            1999
<S>                                                            <C>             <C>
   Computer equipment ......................................    $  357,202      $  368,723
   Office equipment ........................................        44,728          31,151
                                                                ----------      ----------
   Total ...................................................       401,930         399,874
   Less: Accumulated depreciation and amortization .........      (100,638)       (222,321)
                                                                ----------      ----------
   Assets under capital lease - net ........................    $  301,292      $  177,553
                                                                ==========      ==========
</TABLE>

Assets under capital lease are depreciated or amortized over three- to five-year
lives, with expense totaling $14,991,  $85,090, and $128,670 for the years ended
December 31, 1997, 1998, and 1999, respectively.

The future minimum lease payments under capital leases are computed as follows:

<TABLE>
<CAPTION>

YEAR ENDED DECEMBER 31,
-----------------------
<S>                                                                    <C>
      2000 .........................................................    $  130,940
      2001 .........................................................        85,648
      2002 .........................................................        15,351
                                                                        ----------
                                                                           231,939

    Less: Interest .................................................       (26,438)
                                                                        ----------
    Present value of future minimum capital lease payments .........       205,501
    Less: Current portion ..........................................      (113,293)
                                                                        ----------
    Capital lease obligation, net of current portion ...............    $   92,208
                                                                        ==========
</TABLE>

9. NOTES PAYABLE

In 1997, the Company  purchased common stock (treasury stock) from a stockholder
for $49,000 cash and a $70,000 note payable. The note payable specified payments
of $35,000 in February 1998 and February 1999 and was non-interest bearing.

In 1998,  the Company  borrowed  $29,415  against an equipment  loan facility of
$125,000.  This note is interest only monthly,  convertible on a quarterly basis
to a thirty-six  month note with principal and interest due monthly.  Borrowings
under this note are  secured  by  equipment  and  accounts  receivable  and bear
interest at prime plus 1%, which was 8.75% at December 31, 1998.  The  agreement
is personally  guaranteed by the President/Chief  Executive Officer. The balance
was paid in full during 1999.

10. LINE OF CREDIT AND EQUIPMENT LOAN FACILITY

At December 31, 1998, the Company had a line of credit in the amount of $400,000
that was payable on demand.  Borrowings  under this note are secured by accounts
receivable  of the Company and bear interest at prime plus 2% which was 9.75% at
December  31,  1998.  The  agreement  required no  financial  covenants  and was
personally guaranteed by the President/Chief Executive Officer.


                                      F-21

<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


In May 1999, the Company paid off the outstanding amount on the original line of
credit and  outstanding  note  payable and  obtained a new line of credit in the
amount of $1,000,000 consisting of an $800,000 secured revolving credit line and
a $200,000 equipment line of credit.

In August  1999,  the  Company  amended  (Amendment  No. 1) the May 1999 line of
credit agreement to increase the maximum  availability  under the equipment line
to $600,000.

In November  1999,  the Company  amended  (Amendment No. 2) the May 1999 line of
credit  agreement  to  increase  the  maximum  availability  under  each  of the
revolving  credit and the equipment  line to  $1,000,000.  Under this  amendment
interest  rates for the revolving  credit line was adjusted to prime plus 1% and
the interest rate for the equipment line was adjusted to prime plus 1.25%.

In 1999, the Company  borrowed  $960,547  against the equipment loan facility of
$1,000,000. Any outstanding amounts within the first six months of the loan plus
accrued  interest were converted to a term loan.  Borrowings under this note are
secured by personal  property,  including  equipment,  trademarks  and  accounts
receivable of the Company,  bear interest at prime plus 1.25% (9.75% at December
31, 1999) and are subject to certain financial covenants.  In November 1999, all
equipment  line  advances  then  outstanding,  plus any accrued  interest,  were
converted to a term loan (the "First Term Loan").  All  equipment  line advances
made since the First Term Loan conversion  shall be converted into a Second Term
Loan in May 2000.  Each of the First  Term Loan and the  Second  Term Loan shall
provide   repayments   of  principal   and  interest  in  thirty  equal  monthly
installments.  The  Company  must also  maintain  various  financial  covenants,
including minimum cash balance and certain  financial  ratios. In addition,  the
Company  cannot  declare  or pay  dividends  on, or make any  distribution  with
respect to, any class of its equity during the term of this facility.

At December 31, 1999, the amounts  outstanding  under the revolving  credit line
was $550,000  payable by May 2000 with accrued interest due and payable monthly.
Borrowings under this note are secured by accounts receivable of the Company and
bear  interest at prime plus 1% (9.5% at December  31,  1999) and are subject to
certain financial covenants.

The following represents the maturities of the equipment loan facility:

<TABLE>
<CAPTION>

   YEAR ENDED DECEMBER 31,    PRINCIPAL DUE
---------------------------- --------------
<S>                          <C>
     2000 ..................    $337,302
     2001 ..................     397,679
     2002 ..................     225,566
                                --------
     Total .................    $960,547
                                ========
</TABLE>

11. RELATED PARTY TRANSACTIONS

The Company had an arrangement with another  company,  the president of which is
also a member of the  Company's  Board of  Directors,  whereby the other company
provides advisory and fiduciary  oversight services to the Company at an average
monthly fee of $2,500.  This arrangement  ended and was paid in full during July
1999.  Total  fees paid to the other  company  under  this  arrangement  totaled
$26,000  and  $50,000  for  the  years  ended   December   31,  1998  and  1999,
respectively,  and the  Company's  accrued  liability  to the other  company was
$2,000 at December  31,  1998.  There was no accrued  liability  at December 31,
1999.

The Company  engaged a law firm during 1997 and 1998. An attorney at the firm is
also a shareholder  of the Company.  The Company  incurred  $4,751 and $2,098 in
expense to the Firm  during  1997 and 1998,  respectively.  There was no accrued
liability at December 31, 1997 and 1998, respectively.


                                      F-22

<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


The Company  engaged  another law firm during 1998 and 1999.  An attorney at the
firm is also a  shareholder  of the Company.  The Company  incurred  $19,158 and
$227,039 in expense to the firm and the Company's  accrued liability to the firm
was $17,158 and $21,806 at December 31, 1998 and 1999, respectively.

Beginning in 1998,  the Company has an  arrangement  with a  shareholder  of the
Company whereby the shareholder  provides  consulting services to the Company in
the form of technical advise on bioinformatics,  gene expression, and the use of
complex genetic databases, in addition to marketing of the Company's products in
Europe.  This shareholder was paid an average monthly fee of $4,167.  Total fees
paid to the shareholder  under this  arrangement  totaled $8,333 and $50,000 for
the years ended  December  31, 1998 and 1999,  respectively,  and the  Company's
accrued  liability to the shareholder was $4,167 at December 31, 1998. There was
no accrued liability at December 31, 1999.

Beginning in 1999,  the Company has an  arrangement  with a  nonqualified  stock
option  holder of the Company  whereby  the  option-holder  provides  consulting
services to the Company in the form of  bioinformatic  product design advise and
information on market conditions and receptivity to bioinformatic  products,  in
addition to chairing and recommending  participation in the Company's Scientific
Advisory Board.  This  option-holder  was paid an average monthly fee of $4,167.
Total fees paid to the option-holder  under this arrangement totaled $20,833 for
the year ended December 31, 1999.

On April 6, 1999, the Company loaned the President of the Company $65,000, which
is to be paid in full with all  unpaid,  accrued  interest  by April  2004.  The
interest  rate of this  note is  prime  plus 1%  (9.5% at  December  31,  1999).
Interest  income earned during the year and  receivable at December 31, 1999 was
$4,360.

12. BUSINESS SEGMENT AND GEOGRAPHIC AREA INFORMATION

The Company  operates  in one  industry  segment,  the  development  and sale of
computer software programs and related services.

Two customers accounted for 26% and 23% of total accounts receivable at December
31, 1998. The Company's  services to NCBI under two  subcontracts  accounted for
12% of total accounts  receivable at December 31, 1998.  One customer  accounted
for  approximately  14% of total  accounts  receivable at December 31, 1999. The
Company's services to the NCBI under two subcontracts accounted for 18% of total
accounts receivable at December 31, 1999.

The Company's  professional services provided to the NCBI under two subcontracts
accounted for 34% of total revenue for the year ended  December 31, 1998 and 27%
of revenue  for the year ended  December  31,  1999.  There were no sales to any
individual  country except for the United States where such sales  accounted for
10% or more of total revenue.

Substantially  all assets are held in the United States at December 31, 1998 and
1999.

Revenues by geographic  destination and as a percentage of total revenues are as
follows:

<TABLE>
<CAPTION>
                                                     YEAR ENDED
                                    ---------------------------------------------
                                         1997            1998            1999
                                    -------------   -------------   -------------
<S>                                 <C>             <C>             <C>
   GEOGRAPHIC AREA BY DESTINATION
----------------------------------
   United States ................    $1,843,152      $2,882,439     $ 8,513,617
   International ................       358,570       1,243,806       1,500,808
                                     ----------      ----------     -----------
                                     $2,201,722      $4,126,245     $10,014,425
                                     ==========      ==========     ===========
</TABLE>


                                      F-23

<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999

<TABLE>
<CAPTION>
                                                 YEAR ENDED
                                    ------------------------------------
                                       1997         1998         1999
                                    ----------   ----------   ----------
<S>                                 <C>          <C>          <C>
   GEOGRAPHIC AREA BY DESTINATION
----------------------------------
   United States ................       84.0%        70.0%        85.0%
   International ................       16.0         30.0         15.0
                                       -----        -----        -----
                                       100.0%       100.0%       100.0%
                                       =====        =====        =====
</TABLE>

13. COMMITMENTS

Employment  Agreements - All employees hired in 1999 have employment  agreements
that entitle them to two weeks of severance in case of termination. In addition,
three  employees of the Company have  employment  agreements  that entitle these
individuals  to  specified   amounts  of  severance  if  such   individuals  are
terminated.

14. CONTINGENCIES

Government  Audits - Payments  to the  Company on  subcontracts  with prime U.S.
Government  contractors are subject to adjustment upon audit by various agencies
of the U.S. Government. For the years ended December 31, 1997, 1998 and 1999, no
audits of costs and the  related  payments  have been  performed  by the various
agencies.  At December 31, 1998, the Company  accrued a potential  liability for
billings  in excess of costs  incurred  of $79,796  related  to a  cost-plus-fee
contract. In July 1999, this contract was converted to a time and material based
contract by signing new  agreements.  Any potential  liabilities  from the prior
contract  ceased under the new  agreements.  At December 31, 1999,  there are no
liabilities  accrued related to the billing in excess of cost. In the opinion of
management, the final determination of these costs and related payments will not
have  a  material  effect  on  the  Company's  financial  position,  results  of
operations, or liquidity.

Litigation  - In late  1998,  litigation  was filed in France by a former  sales
representative.  A hearing was held in 1999 and according to the decision of the
French  court,  the  Company  has been  directed  to pay  $228,600 to the former
representative. The liability of $228,600 was accrued at December 31, 1999.

15. RETIREMENT PLAN

Effective January 1, 1999, the Company established a 401(k) retirement plan (the
401(k) Plan) covering all eligible employees, as defined. Under the terms of the
401(k)  Plan,  participants  may defer a portion of their  salaries  as employee
contributions  and are immediately  100% vested.  The Company may make matching,
nonelective  or  discretionary  contributions  to the 401(k)  Plan.  In general,
matching and discretionary contributions made by the Company vest ratably over a
three-year  period.  The Company did not make a contribution under this Plan for
1999.

16. SUBSEQUENT EVENTS

In January 2000,  the Company joined in a value-added  reseller and  comarketing
agreement  with  another  company.  The  Company  grants to the other  company a
nonexclusive  worldwide  internal use license and value-added  reseller license.
Each license has a term of two years,  and the Company will receive a sublicense
fee for each copy of the product sublicensed by the other company.

In January  2000,  the Company  joined in  agreement  with a biotech  company to
develop a customized  version of its software for use by the biotech  company in
connection  with  distribution  of the biotech  company's  data through  license
agreements.  The  biotech  company  agrees to pay for the  customization  of the
product  on a  time-and-materials  basis  along  with  any  reasonable  expenses
incurred during the customization of the product.


                                      F-24

<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


In February 2000, the Company increased the line of credit to $3,000,000 and the
equipment line of credit to $3,000,000 (equipment loan). Any outstanding amounts
on the line of credit  are  payable  by  February  2001;  however,  any  accrued
interest is due and payable  monthly.  Borrowings  under this line of credit are
secured by accounts  receivable  of the Company and bear  interest at prime plus
1.00% and are  subject  to certain  financial  covenants,  such as minimum  cash
balances, net worth, and current ratios. Any outstanding amount on the equipment
loan within the first six months of the loan plus any accrued  interest shall be
converted  to a term  loan  in May  2000  with  principal-and-interest  payments
required monthly over a twenty-four month period. Borrowings under this loan are
secured by equipment of the Company,  bear interest at prime plus 1.25%, and are
subject to a minimum level of net worth.

On June 7, 2000,  the Board of Directors  approved the Company's plan to make an
initial public offering of up to $100,000,000 of common stock.

On June 7, 2000 the Board of  Directors  approved  an  increase in the number of
authorized  common  shares  reserved for  issuance  under the  Company's  equity
incentive compensation plan to 6,179,000.

On June 19, 2000,  the Company  amended  (Amendment  No. 5) the May 1999 line of
credit  agreement in connection  with a $3 million  bridge loan.  This amendment
provides a $3 million bridge loan to fund the Company's  operating  expenses and
modifies  certain  financial  covenants.  All outstanding  borrowings  under the
bridge  loan will  accrue  interest  at the prime  rate plus 2.5% to be  payable
monthly beginning on July 15, 2000. All outstanding  borrowings under the bridge
loan  together  with any unpaid  interest  accrued  thereon  will become due and
payable  upon the earlier of (i)  December 19, 2000 and (ii) the closing date of
any initial  public  offering of any capital  stock or any other equity event in
which  the  Company  receives  an  infusion  of at least $3  million  in cash or
non-cash  assets from any holder of our capital stock.  Generally,  in the event
that the Company raises any funds through venture financing,  private placements
of our equity securities,  or strategic  investors,  the Company is obligated to
make a  prepayment  on the  bridge  loan up to the  maximum  amount  outstanding
thereunder. The Company may initially draw up to $1.5 million and up to $500,000
(in  increments of $250,000) in subsequent  months up to the $3 million  maximum
amount.  In  connection  with the  bridge  loan the  Company  issued to the bank
warrants to purchase up to 15,030 shares of common stock for $0.006 per warrant.
In the event that any amounts  under the bridge loan remain due on September 19,
2000, the Company is obligated to issue additional  10,020 warrants to the bank.
The warrants are initially exercisable at $5.99 per share, subject to adjustment
for  certain  dilutive  issuances.  The fair value of each  warrant  granted was
estimated on the date of the grant using the  Black-Scholes  pricing  model with
the following  weighted average  assumptions:  risk-free interest rate of 5.74%,
expected dividend yield of 0%, expected life of one year and expected volatility
of 93%.  A  discount  on the loan was  recorded  equal to the fair  value of the
warrants and will be  amortized  to interest  expense over the term of the loan.
The bank was also issued certain  registration  rights  enabling them to request
the  Company  to  include  the  common  stock  underlying  their  warrants  in a
registration statement filed by the Company.

On June 23, 2000, the Company issued 243,282 shares of common stock in a private
sale  transaction  with three  accredited  investors  and received cash totaling
approximately  $1.55  million.  Of these shares,  156,954 were sold to a related
party.  This related party  relationship  results from common  ownership of this
purchaser and an existing stockholder of the Company.

On June 29, 2000,  the Company issued 313,909 share of common stock in a private
sale   transaction  to  an  accredited   investor  and  received  cash  totaling
approximately $2.0 million. In addition, the Company issued warrants to purchase
25,050 shares of common stock.  The warrants are initially  exercisable at $6.37
per share subject to adjustment for certain dilutive issuances.


                                      F-25

<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


On June  30,  2000,  in  connection  with  the  settlement  and  payment  of the
litigation  liability of $228,600 to the former sales  representative  in France
(see note 14), the Company  purchased from the former sales  representative  the
remaining  26%  interest in its  subsidiary  InforModus  SARL for  approximately
$7,500.

On April 20, 2000, the president of the Company paid $65,000 toward the interest
and principal outstanding under the loan that the Company made in April 1999. On
July 7, 2000, the remaining  principal and interest of approximately  $6,000 was
repaid.

On August 16, 2000, the Company  entered into a Series B Redeemable  Convertible
Preferred  Stock Purchase  Agreement with a purchaser.  The Company  authorized,
issued and sold  950,747  shares of Series B  redeemable  Convertible  Preferred
Stock,  $.01 par  value,  for  $10,000,000  ($10.52  per  share).  The  Series B
Redeemable Convertible Preferred Stock contains similar rights and privileges as
the Company's Series A Redeemable Convertible Preferred Stock and is convertible
into 1,587,747 shares of common stock of the company at any time at a conversion
price of $6.30.  At the time of issuance of the Series B Redeemable  Convertible
Preferred Stock, the deemed fair market value of the underlying common stock was
$15.00 per share.  Therefore,  the  proceeds of  $10,000,000  will be  initially
allocated to  additional  paid-in  capital as a presumed  beneficial  conversion
feature. As the Series B Redeemable  Convertible  Preferred Stock is convertible
at any time,  the entire amount of $10,000,000  will be immediately  accreted to
the Series B  Convertible  Redeemable  Preferred  Stock on August 16,  2000.  In
connection  with the issuance of the Series B Redeemable  Convertible  preferred
stock, the Company entered into joint development and marketing agreements.

On  September  8, 2000,  the Board of  Directors  amended  the equity  incentive
compensation plan to increase the number of shares authorized to 8,179,000.

On September  11, 2000, in connection  with the Company's  contemplated  initial
public  offering of common stock,  the Company filed an amended  certificate  of
incorporation  pursuant  to Board of Director  and  stockholder  approval  which
resulted in a 1.67 for 1 split of common stock,  a change in par value of common
stock from $0.01 to $0.001 per share,  conversion  of nonvoting  common stock to
voting common  stock,  an increase in the  authorized  shares of common stock to
100,000,000,  and the authorization of 20,000,000 shares of preferred stock with
a par value of $0.01.  All references to the number of common shares,  per share
amounts and par values have been restated as  appropriate  to reflect the effect
of the split,  par value  change and change in the  authorized  number of common
shares for all periods presented.

On  September  21,  2000, a lease  agreement  was executed for new  headquarters
offices that the Company is scheduled to take  possession  of in January,  2001.
This  agreement,  which  expires on October 31,  2012,  does not require  rental
payments  during the  initial 90 days of  possession  after which the Company is
required to make rental payments of $1,357,125 a year,  subject to a 2.5% annual
escalation  clause.  Rental  payments may also be adjusted for the Company's pro
rata share of  increases  in  building  expenses  as  defined in the lease.  The
Company is entitled to leasehold  improvement materials amounting to $60,697 and
a leasehold improvement  allowance not to exceed $1,085,700.  The lease requires
the Company to maintain a security  deposit of $1,380,600 of which  $460,200 was
due upon  execution of the lease  agreement  and  $920,400  will be due when the
Company takes  possession.  This security  deposit may be reduced subject to the
Company meeting certain minimum financial requirements.  To satisfy the security
deposit requirement of the lease, PNC Bank, NA has issued an irrevocable standby
letter  of  credit  for  $460,200  in  favor  of the  lessor  which  requires  a
compensating balance arrangement of $460,200.

For the period from July 1, 2000 through September 26, 2000, the Company granted
805,330  qualified options to employees and 33,400  nonqualified  options to one
nonemployee.  These options were issued with exercise  prices ranging from $6.37
to $15.00 per share; the deemed fair


                                      F-26

<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


market value of the  underlying  common stock was $6.37 at each grant date prior
to July 10, 2000 and $15.00 at each grant date thereafter. Deferred compensation
related to the  qualified  options is  $1,289,883  which  will be  amortized  to
expense over a four year vesting  period.  Compensation  related to  nonemployee
options, which vest over a three year period, is $373,037.

17. VALUATION AND QUALIFYING ACCOUNTS

The following  table sets forth  activity in the Company's  accounts  receivable
reserve accounts:

<TABLE>
<CAPTION>
                                  BALANCE AT                                   BALANCE AT
                                   BEGINNING     CHARGES TO                      END OF
                                   OF PERIOD      EXPENSES      DEDUCTIONS       PERIOD
                                 ------------   ------------   ------------   -----------
<S>                              <C>            <C>            <C>            <C>
   Year ended -
   December 31, 1997 .........      $    --        $    --          $ --         $    --
   December 31, 1998 .........           --         15,000            --          15,000
   December 31, 1999 .........       15,000             --            --          15,000
</TABLE>


                                  * * * * * *


















                                      F-27

<PAGE>


================================================================================

     You should rely only on the information  contained in this  prospectus.  We
have not authorized  anyone to provide you with information  different from that
contained in this  prospectus.  We are offering to sell,  and seeking  offers to
buy,  shares of common  stock only in  jurisdictions  where offers and sales are
permitted.  The information  contained in this prospectus is accurate only as of
the  date  of this  prospectus,  regardless  of the  time  of  delivery  of this
prospectus or of any sale of our common stock.

     Until October 27, 2000, all dealers  effecting  transactions  in the common
stock of InforMax,  Inc., whether or not participating in this offering,  may be
required  to deliver a  prospectus.  This is in addition  to the  obligation  of
dealers to deliver a prospectus when acting as underwriters  and with respect to
their unsold allotments or subscriptions.

                       --------------------------------

                                TABLE OF CONTENTS

                       --------------------------------

<TABLE>
<CAPTION>
                                                PAGE
                                               -----
<S>                                            <C>
Prospectus Summary ...........................   3
Risk Factors .................................   9
Special Note Regarding
   Forward-Looking Statements ................  18
Use of Proceeds ..............................  19
Dividend Policy ..............................  19
Capitalization ...............................  20
Dilution .....................................  22
Selected Consolidated Financial Data .........  23
Management's Discussion and Analysis
   of Financial Condition and
   Results of Operations .....................  25
Business .....................................  36
Management ...................................  55
Certain Transactions .........................  65
Principal Stockholders .......................  68
Description of Capital Stock .................  70
Shares Eligible for Future Sale ..............  74
Underwriting .................................  76
Legal Matters ................................  79
Experts ......................................  79
Additional Information .......................  79
Index to Consolidated Financial
   Statements ................................  F-1
</TABLE>

================================================================================



================================================================================


                                [GRAPHIC OMITTED]





                                5,000,000 SHARES






                                  COMMON STOCK





               ------------------------------------------------

                                   PROSPECTUS

               ------------------------------------------------






                            BEAR, STEARNS & CO. INC.

                           U.S. BANCORP PIPER JAFFRAY

                          ADAMS, HARKNESS & HILL, INC.


                                 OCTOBER 2, 2000


================================================================================

<PAGE>




                                [Alternate Page]

                                5,000,000 SHARES



                                [GRAPHIC OMITTED]



                                  COMMON STOCK

                              ------------------


     This is an initial public  offering of 5,000,000  shares of common stock of
InforMax,  Inc. We are selling all of the shares of common stock  offered  under
this prospectus.

     Our common  stock has been  approved  for  listing  on the Nasdaq  National
Market under the symbol "INMX."

     SEE "RISK FACTORS"  BEGINNING ON PAGE 9 TO READ ABOUT RISKS THAT YOU SHOULD
CONSIDER BEFORE BUYING SHARES OF OUR COMMON STOCK.

     NEITHER THE  SECURITIES AND EXCHANGE  COMMISSION  NOR ANY OTHER  REGULATORY
BODY HAS APPROVED OR DISAPPROVED  THESE  SECURITIES OR PASSED ON THE ADEQUACY OR
ACCURACY OF THIS PROSPECTUS.  ANY  REPRESENTATION  TO THE CONTRARY IS A CRIMINAL
OFFENSE.

                              ------------------

<TABLE>
<CAPTION>
                                                     PER SHARE         TOTAL
                                                    -----------   --------------
<S>                                                 <C>           <C>
Public offering price ...........................     $ 16.00      $80,000,000
Underwriting discounts and commissions ..........     $  1.12      $ 5,600,000
Proceeds to InforMax, Inc. ......................     $ 14.88      $74,400,000
</TABLE>

                              ------------------

     We have  granted  the  underwriters  a 30-day  option to  purchase up to an
additional 750,000 shares of common stock from us at the initial public offering
price less the underwriting discount.

     The underwriters are severally  underwriting the shares being offered.  The
underwriters  expect to deliver  the shares in New York,  New York on October 6,
2000.

                              ------------------


BEAR, STEARNS INTERNATIONAL LIMITED

                           U.S. BANCORP PIPER JAFFRAY

                                                    ADAMS, HARKNESS & HILL, INC.


                 The date of this prospectus is October 2, 2000

<PAGE>

                                [Alternate Page]

     No  action  has  been or will be  taken  in any  jurisdiction  by us or any
underwriter  that  would  permit  a  public  offering  of the  common  stock  or
possession or distribution of this prospectus in any  jurisdiction  where action
for that  purpose is  required,  other than in the United  States.  Persons into
whose  possession this prospectus  comes are required by us and the underwriters
to inform  themselves about, and to observe any restrictions as to, the offering
of the common stock and the distribution of this prospectus.

     The shares may not be offered to persons in the United  Kingdom  other than
in circumstances which are deemed not to be an offer to the public in the United
Kingdom for the purposes of the Public  Offers of Securities  Regulations  1995.
Neither this  prospectus,  nor any other document  issued in connection with the
offering of the shares may be issued to any person in the United  Kingdom unless
that person is of a kind  described in Article 11(3) of the  Financial  Services
Act 1986 (Investment Advertisements)  (Exemptions) Order 1996 (as amended) or is
a person to whom such document may be otherwise lawfully issued.

<PAGE>

                                [Alternate Page]

================================================================================


      You should rely only on the information  contained in this prospectus.  We
have not authorized  anyone to provide you with information  different from that
contained in this  prospectus.  We are offering to sell,  and seeking  offers to
buy,  shares of common  stock only in  jurisdictions  where offers and sales are
permitted.  The information  contained in this prospectus is accurate only as of
the  date  of this  prospectus,  regardless  of the  time  of  delivery  of this
prospectus or of any sale of our common stock.

      Until October 27, 2000, all dealers  effecting  transactions in the common
stock of InforMax,  Inc., whether or not participating in this offering,  may be
required  to deliver a  prospectus.  This is in addition  to the  obligation  of
dealers to deliver a prospectus when acting as underwriters  and with respect to
their unsold allotments or subscriptions.

                       --------------------------------

                                TABLE OF CONTENTS

                       --------------------------------

<TABLE>
<CAPTION>
                                                      PAGE
                                                 --------------
<S>                                              <C>
Prospectus Summary ...........................          3
Risk Factors .................................          9
Special Note Regarding
   Forward-Looking Statements ................         18
Use of Proceeds ..............................         19
Dividend Policy ..............................         19
Capitalization ...............................         20
Dilution .....................................         22
Selected Consolidated Financial Data .........         23
Management's Discussion and Analysis
   of Financial Condition and
   Results of Operations .....................         25
Business .....................................         36
Management ...................................         55
Certain Transactions .........................         65
Principal Stockholders .......................         68
Description of Capital Stock .................         70
Shares Eligible for Future Sale ..............         74
Underwriting .................................         76
Legal Matters ................................         79
Experts ......................................         79
Additional Information .......................         79
Index to Consolidated Financial
   Statements ................................         F-1
</TABLE>

================================================================================



================================================================================


                                [GRAPHIC OMITTED]





                                5,000,000 SHARES





                                  COMMON STOCK




               ------------------------------------------------

                                   PROSPECTUS

               ------------------------------------------------



                                  BEAR, STEARNS
                              INTERNATIONAL LIMITED

                           U.S. BANCORP PIPER JAFFRAY

                          ADAMS, HARKNESS & HILL, INC.



                                 OCTOBER 2, 2000


================================================================================




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