INFORMAX INC
S-1/A, 2000-08-31
COMPUTER PROGRAMMING SERVICES
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<PAGE>


    AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON AUGUST 31, 2000
                                                     REGISTRATION NO. 333-41194

================================================================================
                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549
                              ------------------
                                AMENDMENT NO. 1
                                       TO

                                    FORM S-1

                             REGISTRATION STATEMENT
                                     UNDER

                           THE SECURITIES ACT OF 1933

                              ------------------
                                INFORMAX, INC.
            (Exact name of registrant as specified in its charter)




<TABLE>
<S>                                   <C>                            <C>
                  DELAWARE                        7371                    56-1687783
    (State or other jurisdiction of   (Primary Standard Industrial      (IRS Employer
     incorporation or organization)    Classification Code Number)   Identification No.)
</TABLE>


                              ------------------
   6010 EXECUTIVE BOULEVARD, 10TH FLOOR, ROCKVILLE, MD 20852, (301) 984-2206
(Address,  including  zip  code,  and  telephone number, including area code, of
                   registrant's principal executive offices)


                               JOSEPH E. LEHNEN
                            CHIEF FINANCIAL OFFICER

                     6010 EXECUTIVE BOULEVARD, 10TH FLOOR
                              ROCKVILLE, MD 20852

                                (301) 984-2206
(Name,  address,  including zip code, and telephone number, including area code,
                             of agent for service)

                              ------------------

                                   COPIES TO:


<TABLE>
<S>                                       <C>
              MICHAEL J. SILVER                 JEFFREY E. COHEN
           Hogan & Hartson L.L.P.               Coudert Brothers
    111 S. Calvert Street, Suite 1600     1114 Avenue of the Americas
             Baltimore, MD 21202               New York, NY 10036
             (410) 659-2700                      (212) 626-4400
</TABLE>



                              ------------------
     Approximate  date  of  commencement of proposed sale to the public: As soon
as practicable after the Effective Date of this Registration Statement.

     If  any  of  the securities being registered on this Form are to be offered
on  a  delayed or continuous basis pursuant to Rule 415 under the Securities Act
of 1933, check the following box. [ ]
     If  this  Form  is  filed to register additional securities for an offering
pursuant  to  Rule  462(b) under the Securities Act, check the following box and
list  the  Securities Act registration statement number of the earlier effective
registration statement for the same offering. [ ]

     If  this  Form  is a post-effective amendment filed pursuant to Rule 462(c)
under  the  Securities  Act, check the following box and list the Securities Act
registration  statement  number  of the earlier effective registration statement
for the same offering. [ ]

     If  this  Form  is a post-effective amendment filed pursuant to Rule 462(d)
under  the  Securities  Act, check the following box and list the Securities Act
registration  statement  number  of the earlier effective registration statement
for the same offering. [ ]

     If  delivery of the prospectus is expected to be made pursuant to Rule 434,
check the following box. [ ]


                        CALCULATION OF REGISTRATION FEE
--------------------------------------------------------------------------------

<TABLE>
<CAPTION>
                                                                                 PROPOSED
                                                         PROPOSED MAXIMUM         MAXIMUM
       TITLE OF EACH CLASS             AMOUNT TO BE       OFFERING PRICE         AGGREGATE          AMOUNT OF
  OF SECURITIES TO BE REGISTERED        REGISTERED         PER UNIT (1)     OFFERING PRICE (1)   REGISTRATION FEE
--------------------------------- --------------------- ------------------ -------------------- -----------------
<S>                               <C>                   <C>                <C>                  <C>
Common Stock, par value $0.001 .. 5,750,000 shares(2)        $ 16.00            $92,000,000        $  24,288 (3)
</TABLE>


--------------------------------------------------------------------------------


(1) Estimated  solely  for  the  purpose  of calculating the registration fee in
accordance with Rule 457(o) under the Securities Act.
(2) Includes  750,000  shares which the underwriters have the option to purchase
to cover over-allotments, if any.
(3) $19,800 previously paid.

     THE  REGISTRANT  HEREBY  AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES  AS  MAY  BE  NECESSARY  TO  DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT
SHALL  FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION
STATEMENT  SHALL  THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE  SECURITIES  ACT, OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME EFFECTIVE
ON  SUCH  DATE  AS  THE  COMMISSION,  ACTING  PURSUANT TO SAID SECTION 8(A), MAY
DETERMINE.

================================================================================
<PAGE>


                 SUBJECT TO COMPLETION, DATED AUGUST 31, 2000

PRELIMINARY PROSPECTUS

                               5,000,000 SHARES


                               [GRAPHIC OMITTED]

                                  COMMON STOCK
                              ------------------

     This  is  an initial public offering of 5,000,000 shares of common stock of
InforMax,  Inc.  We  are selling all of the shares of common stock offered under
this prospectus.

     We  expect  the  public  offering  price for our common stock to be between
$14.00  and $16.00 per share. There is currently no public market for our common
stock.  We  have  applied  to  have our common stock approved for listing on the
Nasdaq National Market under the symbol "INMX."


     SEE  "RISK FACTORS" BEGINNING ON PAGE 9 TO READ ABOUT RISKS THAT YOU SHOULD
CONSIDER BEFORE BUYING SHARES OF OUR COMMON STOCK.

     NEITHER  THE  SECURITIES  AND  EXCHANGE COMMISSION NOR ANY OTHER REGULATORY
BODY  HAS  APPROVED OR DISAPPROVED THESE SECURITIES OR PASSED ON THE ADEQUACY OR
ACCURACY  OF  THIS  PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL
OFFENSE.

                              ------------------

<TABLE>
<CAPTION>
                                                     PER SHARE       TOTAL
                                                    -----------   ----------
<S>                                                 <C>           <C>
Public offering price ...........................     $            $
Underwriting discounts and commissions ..........     $            $
Proceeds to InforMax, Inc. ......................     $            $
</TABLE>


                              ------------------
     We  have  granted  the  underwriters  a  30-day option to purchase up to an
additional  750,000  shares  of  common  stock  from  us  at  the initial public
offering price less the underwriting discount.

     The  underwriters  are severally underwriting the shares being offered. The
underwriters  expect to deliver the shares in New York, New York on      , 2000.



                              ------------------
BEAR, STEARNS & CO. INC.

                           U.S. BANCORP PIPER JAFFRAY

                                                    ADAMS, HARKNESS & HILL, INC.


                  The date of this prospectus is        , 2000

THE  INFORMATION  IN  THIS  PRELIMINARY  PROSPECTUS  IS  NOT COMPLETE AND MAY BE
CHANGED.  WE  MAY  NOT  SELL  THESE  SECURITIES UNTIL THE REGISTRATION STATEMENT
FILED  WITH THE SECURITIES AND EXCHANGE COMMISSION IS EFFECTIVE. THIS PROSPECTUS
IS  NOT  AN OFFER TO SELL THESE SECURITIES, AND IT IS NOT SOLICITING AN OFFER TO
BUY  THESE  SECURITIES,  IN  ANY  JURISDICTION  WHERE  THE  OFFER OR SALE IS NOT
PERMITTED.
<PAGE>

[At  the  top  of  the page of the inside front cover appears numerous series of
the  letters  "C,"  "A,"  "G"  and  "T"  in varied order, size, shade and color,
including  red, blue, green and white. The letters are surrounded by and overlay
various  numbers,  preceded  by  "+" signs. The numbers and letters appear as if
they  are  rapidly  moving  horizontally  across  the  page. Beneath the graphic
appears the caption, "What's behind the genomic revolution?"]


[The  bottom  third  of  the  page  along  the  right  side begins with the word
"InforMax"  in  black  and  InforMax's  greenish-blue,  Double Helix Logo Design
above "High-Throughput Research(TM)."

[Along  the  top  left  third  of  the inside two-page gatefold appears numerous
series  of  the  letters  "C," "A," "G" and "T" in varied order, size, shade and
color,  including  red, blue, green and white. The letters are surrounded by and
overlay  various  numbers, preceded by "+" signs. The numbers and letters appear
as  if they are rapidly moving horizontally across the page. Running through the
middle  of  the  graphic  is a green horizontal line with various vertical lines
branching  out  above  and  below the horizontal line. The vertical lines end in
bullets  with  the  following  words appearing next to the bullets, from left to
right  alternatively  above  and  below  the  green  horizontal  line: "Customer
Databases,"  "Online  Data,"  "Integration  of  Data  Types," "Our ResearchLogic
Interface,"  "Java  Framework,"  "Analysis,"  "Customized Data Presentation" and
"Collaboration."  Perpendicular  to  the  green horizontal line, at the far left
end  of  the  graphic above the green horizontal line is the word "Input" in red
font  with  an  arrow  pointing  to the phrase "Experimental Data" preceded by a
blue  bullet  appearing  below  the  green horizontal line. Perpendicular to the
green  horizontal  line,  at  the  far  right end of the graphic above the green
horizontal  line  is  the  word  "Results" in red font with an arrow pointing to
"Knowledge,"  "Productivity,"  and  "Products,"  each  preceded by a blue bullet
appearing  below  the  green  horizontal  line. Beneath the far left side of the
graphic is the phrase "From Data to Knowledge."]

[Along  the  bottom  two thirds of the two page gatefold on the left side is the
caption  "GenoMax,"  above  three  pictures of computer screens, one for each of
"Blast  Results  View,"  "SimBlockView," and "Array Analysis View." Beneath that
is  the  phrase  "Enterprise Bioinformatics System for High-Throughput Research"
in  a  less  bold  style.  On  the right side is the caption "Vector NTI Suite,"
above   three  pictures  of  computer  screens  for  each  of  "Molecule  View,"
"BioPlot(TM)"  and  "ContigExpress.(TM)"  Beneath  that  is  the phrase "Desktop
Software  for  Integrated  Sequence Analysis and Data Management" in a less bold
style.]

[In  the  bottom  right  hand corner of the two-page gatefold appears "InforMax"
and  InforMax's  greenish-blue  Double Helix Logo Design, above "High-Throughput
Research(TM)."]

<PAGE>

                              PROSPECTUS SUMMARY


     You  should  read  the  following  summary  together with the more detailed
information  regarding  our  company  and  our  common  stock being sold in this
offering  and  our  consolidated  financial  statements  and  the  notes  to our
consolidated  financial statements appearing elsewhere in this prospectus before
making  an  investment  decision.  You  should  also  consider  the  information
discussed in "Risk Factors."


OUR BUSINESS


     We  are  a  leading  global  provider  of bioinformatic software solutions.
Bioinformatics  involves  the  application  of  information  technology  to  the
analysis  of  genomic,  proteomic  and  other biomolecular data. Genomics is the
study  of an organism's genes, and proteomics is the study of proteins and their
role  in  particular diseases. Our bioinformatic software solutions are designed
to   enable  researchers  to  more  efficiently  organize,  share,  analyze  and
interpret these data that form the genetic blueprint of all organisms.

     Since  introducing  our  Vector  NTI  Suite  of  software  applications for
desktop   computers   in   1993,  we  have  sold  our  products  to  over  1,300
organizations  worldwide,  including  over 500 biotechnology, pharmaceutical and
agricultural  biotechnology  companies,  and  over  800  academic and government
research institutions. Our customers include:


       o Merck & Company,
       o Genzyme Corporation,
       o Procter & Gamble,
       o Johnson & Johnson,
       o Bristol-Myers Squibb,
       o Pfizer,
       o AstraZeneca,
       o Diversa Corporation,
       o Novartis Agribusiness Biotechnology Research,
       o the Whitehead Institute for Biomedical Research,
       o Massachusetts Institute of Technology,
       o University of Tokyo, and
       o the National Institutes of Health.

     Our  principal  software  products  are  our  Vector  NTI Suite for desktop
computers  and our more powerful and expensive GenoMax enterprise platform for a
network  of  computers  linked together for sharing data and computation. Driven
primarily  by  increased  sales  of  Vector  NTI  Suite  and the introduction of
GenoMax  in  late  1998,  our  products and complementary services generated $10
million  in  revenues  in  1999, representing a four-year compound annual growth
rate of 105%, and a 143% increase over 1998.

     Building  on  our  existing  market  penetration,  we  intend  to  grow our
business   through   increased  software  sales  and  add  new  revenue  through
professional   services,  content  channeling  and  distribution  alliances  and
e-commerce  offerings.  In  August  2000,  we entered into a long-term strategic
relationship  with Amersham Pharmacia Biotech, a subsidiary of Nycomed Amersham,
to  jointly  develop  and  market  an  expanded version of GenoMax to provide an
enterprise-wide   data   analysis   system  for  pharmaceutical  companies,  for
integrating  and  analyzing  data  from  genomics, proteomics and drug screening
production laboratories.

     As  of  August  23,  2000,  we  employed  192 people, including a sales and
marketing  team  of  51,  a  research  and product development team of 90 and an
implementation and support staff of 23.

     As  of  June  30, 2000, we had an accumulated deficit of $8.2 million and a
net loss of $6.1 million for the six months ended June 30, 2000.


                                       3
<PAGE>

OUR MARKET OPPORTUNITY


     Around  the  world,  researchers  in industry, academia, and government are
producing  vast  quantities of biomolecular data. In June 2000, the Human Genome
Project  and  Celera  Genomics  jointly  announced  that  they had assembled the
world's  first  working  draft  of  the entire human genetic code, consisting of
approximately  3.12 billion nucleotide bases, the chemical subunits that make up
DNA.

     A  central  problem  now  facing researchers is how to organize, integrate,
analyze,  visualize and interpret these complex and rapidly growing data sets to
achieve breakthroughs in:

     o disease diagnosis, treatment and prevention,

     o agricultural production,

     o environmental management, and

     o industrial processes.

Bioinformatic  software  provides tools for researchers to address this problem.
We  believe  that  the  current  and  future  markets for bioinformatic software
products  include all of the industries participating in the genomic revolution,
including:

     o pharmaceutical and biotechnology companies;

     o academic and government research institutions;

     o agricultural, environmental and industrial biotechnology companies; and

     o emerging clinical genomics companies.

     An  August  2000  independent  industry  report  by  Front  Line  Strategic
Management   Consulting   estimates   the   world-wide   bioinformatics  market,
consisting  of sales by providers of analytical software, enterprise systems and
data,  at  approximately  $468  million  in  2000, growing to approximately $2.0
billion  in  2005  and  approximately $5.4 billion in 2010. We believe that this
growth  is  being  driven  by  the  rapid  increase  in biomolecular data and by
organizations   increasingly   turning  to  external  vendors  of  bioinformatic
software solutions so that they can focus on their core research competencies.

OUR SOLUTION

     To  meet  the  challenges and market opportunities presented by the genomic
revolution,  we  develop and deliver to our customers a portfolio of proprietary
bioinformatic   software  products  and  complementary  services.  Our  software
products  are flexible, scalable and are designed to integrate with one another.
Our  software  allows  researchers  to  incorporate,  directly,  or  through the
Internet,  customer  and  third  party  analytical algorithms and data sets. Our
current and announced product portfolio includes:


   o Vector   NTI   Suite,   a   comprehensive  desktop  sequence  analysis  and
     visualization  tool  for  the  laboratory  scientist engaged in genomic and
     protein sequence research.

   o Vector   Enterprise,   an   enhancement   to  the  Vector  NTI  Suite  that
     incorporates  a  common  relational  database,  allowing  multiple users to
     share  data  and  results  in  a  secure  environment. Vector Enterprise is
     scheduled for commercial launch in the third quarter of 2000.


   o GenoMax,  a  large-scale  modular, enterprise-wide data mining and analysis
     application  designed  for  a  coordinated  effort  by  a  diverse  team of
     scientists  within  or  across  commercial, academic or government research
     institutions.  As  of  August 31, 2000, 18 organizations engaged in genomic
     research have purchased GenoMax.


                                       4
<PAGE>

OUR ADVANTAGES


     We  believe that our competitive advantages will allow us to continue to be
a global leader in bioinformatic software solutions:


     o Superior products and a broad product portfolio;

     o Superior bioinformatic engineering staff;

     o Large existing customer franchise;

     o Vector NTI Suite's  market  penetration,  which creates opportunities for
       new products and business lines; and

     o Superior sales and marketing capabilities.

OUR STRATEGY

     Our  goal  is  to  become  the  leading  provider of bioinformatic software
solutions  and  establish  our  products  as  the  effective  industry standard.
Elements of our strategy to achieve these goals include:

     o Expand our customer franchise through sales of Vector NTI Suite;

     o Build on Vector  NTI  Suite's  market penetration to establish GenoMax as
       the leading enterprise platform;

     o Leverage our customer base for new business lines, including professional
       services, content channeling  and  distribution  alliances and e-commerce
       opportunities;

     o Enhance and expand our technology;

     o Establish strategic relationships to maximize our revenues; and

     o Engage in acquisitions and strategic investments.

OUR OFFICES


     InforMax,  Inc.  was  incorporated  in  Delaware in May 1990. Our principal
office  is  located  at  6010  Executive  Blvd., 10th Floor, Rockville, Maryland
20852.   Our   telephone   number   is   (301)   984-2206.   Our   website   is
www.informaxinc.com.  The  information  found on our website is not part of this
prospectus.



                                       5
<PAGE>

                                 THE OFFERING




<TABLE>
<S>                                                            <C>
Common stock offered by us .................................   5,000,000 shares

Common stock to be outstanding after this offering .........   18,128,514 shares

Use of proceeds ............................................   We will use the net
                                                               proceeds of this offering for
                                                               acquisitions, joint ventures
                                                               and collaborative
                                                               arrangements; research and
                                                               development; increased
                                                               sales and marketing efforts;
                                                               and working capital and
                                                               other general corporate
                                                               purposes.

Proposed Nasdaq National Market symbol .....................   "INMX"
</TABLE>



     The  above  information is based on our shares outstanding as of August 23,
2000 and excludes:

     o 13,470,517 shares   issuable   upon  exercise  of  common  stock  options
       outstanding, including   5,185,735  issued  under  our  equity  incentive
       compensation plan at  a  weighted  average  exercise  price of $0.708 per
       share;

     o an aggregate of  1,131,528  shares reserved for future issuance under our
       equity incentive compensation plan; and

     o outstanding warrants to purchase 40,080 shares of our common stock.

     Unless otherwise indicated, the information in this prospectus assumes:

     o a  1.67  for  1  split  of  our  common stock to be effected prior to the
       closing of the offering;

     o the reduction, to  be  effected  prior to the closing of the offering, of
       our common stock's par value from $0.01 per share to $0.001 per share;

     o the filing of our amended and restated  certificate of incorporation,  to
       be  effected  prior  to the  closing  of  the  offering,  converting  our
       non-voting class of common stock into voting common stock and authorizing
       a single  class of common  stock  after the  offering,  and making  other
       changes as are described elsewhere in this prospectus,  and the amendment
       of our bylaws;

     o the automatic conversion  of  our  outstanding  Series  A  and  Series  B
       redeemable convertible preferred stock into common stock upon the closing
       of the offering; and

     o no exercise by  the  underwriters  of their option to purchase additional
       shares of stock in the offering to cover over-allotments, if any.



                                       6
<PAGE>

                  SUMMARY CONSOLIDATED FINANCIAL INFORMATION

     The  following table sets forth a summary of our consolidated financial and
certain  operating  data for the periods presented. The information in the table
should  be  read together with our consolidated financial statements and related
notes  and  with  "Selected  Financial  Data"  and  "Management's Discussion and
Analysis  of  Financial Condition and Results of Operations," included elsewhere
in this prospectus.




<TABLE>
<CAPTION>
                                                                 YEAR ENDED DECEMBER 31,
                                               -----------------------------------------------------------
                                                  1995      1996       1997         1998          1999
                                               ---------- -------- ------------ ------------ -------------
                                                          (IN THOUSANDS EXCEPT PER SHARE DATA)
<S>                                            <C>        <C>      <C>          <C>          <C>
STATEMENTS OF OPERATIONS DATA:
Revenues:
  Software license and customer support          $  166    $  382    $  1,335     $  2,732     $   7,277
  Professional services ......................      403       636         867        1,394         2,737
                                                 ------    ------    --------     --------     ---------
   Total revenues ............................      569     1,018       2,202        4,126        10,014
Gross profit .................................      405       690       1,448        2,855         7,997
Operating expenses:
  Selling, general and administrative (1)           195       507       1,075        2,476         7,000
  Research and development (2) ...............      165       161         365        1,162         2,597
  Stock based compensation ...................       22        --         211           18           138
  Depreciation and amortization ..............       --         3          18           94           273
                                                 ------    ------    --------     --------     ---------
   Total operating expenses ..................      382       671       1,669        3,750        10,008
Income (loss) from operations ................       23        19        (221)        (895)       (2,011)
Net income (loss) ............................   $   22    $    4    $   (134)    $   (567)    $  (1,315)
Net income (loss) applicable to common
  shares .....................................   $   22    $    4    $   (134)    $   (567)    $  (1,491)
Basic net income (loss) applicable per
  common share ...............................   $ 0.01    $   --   $   (0.04)   $   (0.16)    $   (0.38)
Diluted net income (loss) applicable per
  common share ...............................   $ 0.01    $   --   $   (0.04)   $   (0.16)    $   (0.38)


<CAPTION>
                                                    SIX MONTHS ENDED
                                                        JUNE 30,
                                               --------------------------
                                                   1999          2000
                                               ------------ -------------
                                                      (UNAUDITED)
                                                (IN THOUSANDS EXCEPT PER
                                                       SHARE DATA)
<S>                                            <C>          <C>
STATEMENTS OF OPERATIONS DATA:
Revenues:
  Software license and customer support          $  3,322     $   4,855
  Professional services ......................      1,159         1,655
                                                 --------     ---------
   Total revenues ............................      4,481     $   6,510
Gross profit .................................      3,604         5,397
Operating expenses:
  Selling, general and administrative (1)           2,397         7,565
  Research and development (2) ...............      1,129         2,471
  Stock based compensation ...................         27           975
  Depreciation and amortization ..............         89           343
                                                 --------     ---------
   Total operating expenses ..................      3,642        11,354
Income (loss) from operations ................        (38)       (5,957)
Net income (loss) ............................   $    (82)    $  (6,069)
Net income (loss) applicable to common
  shares .....................................   $    (82)    $  (6,237)
Basic net income (loss) applicable per
  common share ...............................  $   (0.02)    $   (1.48)
Diluted net income (loss) applicable per
  common share ...............................  $   (0.02)    $   (1.48)
</TABLE>



-----------
(1) Selling,   general   and   administrative   expenses  excludes  stock  based
    compensation   of  $21,916,  $-0-,  $76,189,  $-0-,  $111,019,  $9,643,  and
    $845,741  for  the years ended December 31, 1995, 1996, 1997, 1998, and 1999
    and  the  six months ended June 30, 1999 and 2000 (unaudited), respectively.


(2) Research  and  development  expenses  excludes  stock  based compensation of
    $-0-,  $-0-,  $134,506,  $17,782,  $27,166,  $16,748,  and  $128,874 for the
    years  ended  December  31,  1995,  1996,  1997,  1998, and 1999 and the six
    months ended June 30, 1999 and 2000 (unaudited), respectively.



     Following is certain supplemental information for the period presented:


<TABLE>
<CAPTION>
                                                                            SIX MONTHS ENDED
                                        YEAR ENDED DECEMBER 31,                 JUNE 30
                            ----------------------------------------------- ----------------
                             1995     1996      1997      1998      1999       1999    2000
                            ------ --------- --------- --------- ---------- --------- ------
                                                                              (UNAUDITED)
                              (IN THOUSANDS, EXCEPT NUMBER OF VECTOR NTI
                                                 SUITE
                              LICENSES BOOKED AND NUMBER OF GENOMAX SALES
                                                BOOKED)
<S>                         <C>    <C>       <C>       <C>       <C>        <C>       <C>
Revenue Bookings ..........  $569   $1,033    $2,575    $5,571    $10,087    $3,025   8,994
No. of Vector NTI
  Licenses Booked
  (cumulative) ............
No. of Genomax Sales
  Booked (cumulative) .....    --       --        --         2          8         3      16
</TABLE>



     Revenue bookings represent all contracted sales of products and services.


                                       7
<PAGE>


     The  balance  sheet  data  below  sets  forth a summary of our consolidated
balance sheet at June 30, 2000:

     o on an actual basis;

     o on a pro  forma  basis  to  give  effect  to  the  issuance  of  Series B
       redeemable convertible preferred stock after June 30, 2000, the automatic
       conversion  of  all  outstanding  shares  of our  redeemable  convertible
       preferred stock into common stock upon the closing of this offering,  and
       the conversion of the outstanding  nonvoting  common stock into shares of
       common stock upon the closing of this offering; and

     o on a pro forma as adjusted basis to give effect to the issuance of Series
       B  redeemable  convertible  preferred  stock  after  June 30,  2000,  the
       automatic   conversion  of  all  outstanding  shares  of  our  redeemable
       convertible  preferred  stock into common  stock upon the closing of this
       offering,  the conversion of the outstanding  nonvoting common stock into
       shares of common stock upon the closing of this offering, and our receipt
       of the estimated net proceeds from the sale of 5,000,000 shares of common
       stock in this offering at an assumed  initial  public  offering  price of
       $15.00 per share,  the mid-point of the offering  range,  after deducting
       estimated  underwriting  discounts  and  commissions  and  our  estimated
       offering expenses.



<TABLE>
<CAPTION>
                                                                   AS OF JUNE 30, 2000
                                                        -----------------------------------------
                                                                       (UNAUDITED)
                                                                                     PRO FORMA AS
                                                           ACTUAL      PRO FORMA       ADJUSTED
                                                        -----------   -----------   -------------
                                                                     (IN THOUSANDS)
<S>                                                     <C>           <C>           <C>
BALANCE SHEET DATA:
Cash and cash equivalents ...........................    $  2,091       $12,091        $80,641
Working capital (deficit) ...........................      (1,283)        8,717         77,267
Total assets ........................................      10,109        20,109         88,659
Total debt ..........................................       3,556         3,556          3,556
Redeemable convertible preferred stock ..............       4,263            --             --
Common stock and additional paid-in capital .........       6,269        20,532         89,082
Stockholders' equity (deficit) ......................      (3,449)       10,814         79,364
</TABLE>



     See  our  consolidated financial statements and notes included elsewhere in
this  prospectus  for a description of the computation of the historical and pro
forma  net loss per common share and the number of shares used in the historical
and  pro forma per share calculations in the statement of operations data above.




                                       8
<PAGE>

                                 RISK FACTORS


     You  should carefully consider the following risks before you decide to buy
our  common  stock.  Our business, financial condition and operating results may
suffer  if  any  of  the events described in the following risk factors actually
occur.  If  any of the events we have identified occur, the trading price of our
common  stock  could decline, and you may lose all or part of the money you paid
to buy our common stock in this offering.

                        RISKS RELATED TO OUR BUSINESS

WE  MUST  KEEP  PACE  WITH  RAPID  TECHNOLOGICAL  ADVANCES  AND DEVELOPMENTS NOW
OCCURRING  IN  BIOINFORMATIC  SOFTWARE.  IF WE ARE UNABLE TO DO SO, OUR PRODUCTS
AND  SERVICES  WILL  BE  LESS  ATTRACTIVE  TO  CUSTOMERS  AND  OUR  REVENUES AND
COMPETITIVE POSITION WILL SUFFER.

     The  market  for  our  products  and  services  is  in  the  midst of rapid
technological  change. In order for us to maintain a competitive position in our
industry  and  develop  and market products that are attractive to customers, we
must:

     o continue  to  enhance  and expand the functions of our existing products;
       and

     o develop and introduce  new  software  products and complementary services
       that meet evolving  customer needs and  preferences  and  incorporate new
       technologies.

Our  products  and  services  may  not  be  able to keep pace with technological
change.  We  may  not  be able to identify in a timely manner important evolving
industry  standards  and  may invest considerable resources in technologies that
rapidly  become  obsolete.  Our  products  or  product  versions may also become
obsolete   due   to  our  competitors'  introduction  of  products  or  services
containing  advanced  technology  and  functions.  If  we  do not keep pace with
technological  change  our  products  will not be as attractive to customers and
our competitive position and sales of our products would be seriously harmed.

WE  MUST  ADD  NEW  CUSTOMERS  AND  RETAIN  AND  EXPAND  UPON  EXISTING CUSTOMER
RELATIONSHIPS  IN  ORDER  TO  GENERATE  REVENUES  TO  SUPPORT  THE GROWTH OF OUR
BUSINESS.

     In  order  to  generate  additional  revenues  sufficient  to  support  our
continued  growth,  we  must  add new customers and retain, and expand upon, our
existing  customer  relationships.  These  efforts depend significantly upon our
successful  development  of  new  products,  product  versions and services that
respond  to the evolving needs of the genomic research community, as well as the
success   of  our  sales  and  marketing  efforts.  In  addition,  much  of  our
expectation  for  future growth of revenues is based upon increased sales of our
GenoMax  product and the establishment of our GenoMax brand. We expect to derive
a  significant  portion  of  our  future  professional  services  revenue from a
relationship  with  the  National Center for Biotechnology Information (NCBI) at
the  National  Institutes  of  Health  and  that relationship, which is based on
subcontractor arrangements, could be terminated in the future.

THE  CONTINUED  ENHANCEMENT  AND  DEVELOPMENT  OF OUR BIOINFORMATIC PRODUCTS AND
SERVICES  DEPEND  UPON  THE  RETENTION AND EXPANSION OF OUR RESEARCH AND PRODUCT
DEVELOPMENT GROUP.

     The  number  of  technical  personnel  with  experience  in  the  field  of
bioinformatics  is  limited  and competition for qualified employees is intense.
Our  software  was  developed  by an internal team that has had little turnover,
but  that  may  not  be  the  case  in  the  future. We may not be successful in
retaining  our technical employees or recruiting and training additional skilled
personnel.  The  loss  of  a significant number of employees in our research and
product  development  group, occurring at one instance or over a period of time,
could  seriously  harm our product development and enhancement efforts. We could
also  incur  significant  costs  associated  with  any  resulting  litigation or
disputes to protect our proprietary information.


                                       9
<PAGE>


PART  OF OUR BUSINESS STRATEGY IS TO DEVELOP STRATEGIC RELATIONSHIPS WITH LARGER
ORGANIZATIONS  AND  PROVIDERS OF COMPLEMENTARY PRODUCTS AND SERVICES, AND WE MAY
NOT BE SUCCESSFUL IN DOING SO.

     A   component   of   our   business   strategy   is  to  develop  strategic
relationships,  including  co-marketing  arrangements,  content  channeling  and
distribution   alliances,  e-commerce  offerings  and  Internet-hosted  delivery
partnerships.  We  believe  that through such relationships we can add revenues,
improve  our  competitive  position and increase market awareness and acceptance
of  our  products.  To  date, we have entered into only a few of these strategic
relationships  with  providers of complementary products and services. If we are
unable  to  successfully  develop  these  and other similar relationships, or if
these  relationships  do  not  yield  the  results we anticipate, our ability to
compete and to generate future revenues could be materially harmed.

     In  August  2000,  we  entered into a long-term strategic relationship with
Amersham  Pharmacia Biotech to jointly develop and market an expanded version of
GenoMax  for  pharmaceutical  companies  for integrating and analyzing data from
genomics,  proteomics and drug screening production laboratories. The agreements
with  Amersham can be terminated prior to the end of term based upon a breach by
the  other  party and are subject to testing and acceptance periods for products
jointly  developed. If the agreements are terminated for any reason prior to the
end  of  the  term  or  if  the  relationship  otherwise  does not result in the
successful  marketing  of  GenoMax  to  new customer groups, we may be unable to
recoup   all   of   the  substantial  investment  we  will  be  making  in  this
collaboration  and  there  would be a material adverse impact on our anticipated
future revenues.

WE  HAVE  INCURRED  OPERATING  LOSSES  IN  THE  PAST RESULTING IN AN ACCUMULATED
DEFICIT. WE MAY NOT ACHIEVE OR MAINTAIN PROFITABILITY IN THE FUTURE.

     We  have  incurred operating losses in most periods since our inception. We
incurred  net  losses  of approximately $0.6 million for the year ended December
31,  1998  and  approximately $1.3 million for the year ended December 31, 1999.
As  of  June  30,  2000,  we  had  an  accumulated deficit of approximately $8.2
million  and  a net loss of $6.1 million for the six months ended June 30, 2000.
We  expect to continue to incur net losses for the foreseeable future. We expect
to invest substantial financial and other resources to:

     o develop and introduce new products, product versions and services;

     o expand  each  of  our  research  and  product  development  and sales and
       marketing groups; and

     o consider appropriate acquisitions and strategic relationships.

     As  a  result,  we expect that our expenses will increase significantly. We
cannot  assure  you  that  we  will  be  able  to generate sufficient additional
revenues   to   achieve   profitability.   Even   if  we  are  able  to  achieve
profitability,  we  may  not  be able to sustain profitability on a quarterly or
annual  basis.  Failure to achieve consistent profitability may limit our growth
potential and the value of our common stock.

REVENUE  RECOGNITION  RULES  APPLICABLE  TO  SOFTWARE  MAY REQUIRE THAT WE DEFER
RECOGNIZING  REVENUES  UNDER  CERTAIN LICENSES UNTIL QUARTERS AFTER LICENSES ARE
EXECUTED  OR  FEES  ARE  RECEIVED.  THIS  CAN  CAUSE  OUR  QUARTERLY  RESULTS TO
FLUCTUATE SUBSTANTIALLY.

     Under  generally  accepted  accounting  principles,  we  may  not recognize
revenue  associated  with  a  particular software license in the same quarter in
which  we  enter into the agreement or in which we collect licensing fees. Under
some  of  our licenses we must deliver to a customer an enhanced product version
or  additional  module,  and  therefore  we  must  defer recognizing any payment
previously  received  until  delivery  of  all  contract  elements  is made. For
example,  in  several  of  our  GenoMax  sales, our contracts with our customers
stipulate  future  delivery  of a gene expression analysis module. In accordance
with  generally  accepted accounting principles, we have deferred recognition of
revenue  on  these  contracts  until  delivery  of  the gene expression analysis
module.  This  module  is  scheduled  for delivery as part of GenoMax 3.0 in the
third  quarter of 2000. If we do not release GenoMax 3.0 in the third quarter of
2000  as  scheduled,  we  will  be  required  to  defer  a significant amount of
revenues


                                       10
<PAGE>


that  we  currently  anticipate recognizing in that quarter. Expenses associated
with  software licenses, unlike revenues, are not typically deferred. The manner
in  which we recognize revenue, in accordance with the revenue recognition rules
applicable  to  software  under  generally  accepted  accounting principles, may
cause our quarterly operating results to fluctuate substantially.

WE  EXPECT  OUR  RESULTS OF OPERATIONS TO VARY FROM QUARTER TO QUARTER IN FUTURE
PERIODS  AS  A RESULT OF THE TIMING AND SEASONALITY OF OUR SOFTWARE SALES. THESE
FLUCTUATIONS  MAKE  IT  DIFFICULT  TO  EVALUATE  OUR  BUSINESS  AND  COULD CAUSE
INSTABILITY IN OUR STOCK PRICE.

     We  anticipate  that  our  operating  results will fluctuate on a quarterly
basis  as  a  result  of  a  number of factors, many of which are outside of our
control.  Factors  that may cause our quarterly results to fluctuate include the
following:

     o the number and timing of orders for our GenoMax enterprise product;

     o the  seasonal  fluctuations  of  software  procurement,  particularly for
       bioinformatics software;

     o the timing of,  commencement,  delay,  cancellation  or completion of our
       software licensing agreements,  strategic  relationships and professional
       service activities;


     o the  timing  of  license,  royalty  and other payments received under our
       agreements;


     o the  introduction  or cancellation of products and services by us and our
       competitors; and

     o the timing of  expenses  associated  with  increased product development,
       expanded  sales and marketing  efforts,  and  acquisitions  and strategic
       investments.

     In  particular,  as  a  result  of the academic calendar, European business
practices  and  commercial  information  technology  procurement  practices,  we
generally  experience a reduction in sales in the third quarter of each calendar
year   which  typically  results  in  a  corresponding  reduction  in  operating
revenues.


     Due  to  the  factors  described  above  and  other risks discussed in this
prospectus,  you  should  not  rely  upon quarterly comparisons of our financial
results.  These  comparisons  are  not  necessarily  meaningful  nor  are they a
reliable  indicator  of  our  future performance. As a result of fluctuations in
our  quarterly  results,  the market price of our common stock may be subject to
significant fluctuation and volatility.


OUR  PRODUCTS  AND  SERVICES,  PARTICULARLY  OUR  ENTERPRISE SOFTWARE SOLUTIONS,
REQUIRE  A  LENGTHY  SALES  CYCLE.  THIS SALES CYCLE OFTEN REQUIRES US TO EXPEND
CONSIDERABLE  RESOURCES. IF WE DEVOTE SIGNIFICANT RESOURCES TO SALES THAT DO NOT
MATERIALIZE,  OUR REVENUES AND ABILITY TO ACHIEVE PROFITABILITY WOULD BE HARMED.

     The  sales cycle for our products and services, particularly our enterprise
software  solutions,  on  which  much  of our expectations for future growth are
based,  is a lengthy and involved process. Our sales cycle is typically long for
a number of reasons, including:

   o the  decision  to  license  and  deploy  enterprise-wide  software,  by its
     nature,  is  an  organization-wide procurement decision, often requiring an
     evaluation  by a significant number of constituencies in various functional
     and  geographic  areas, each often having specific and possibly conflicting
     requirements; and


   o the  significant  resources  that  are  committed  to  an evaluation of our
     software  solutions  by  a  potential  customer  organization require us to
     expend  substantial  time,  effort and money educating them about the value
     and comparative advantages of our products.


In  addition, our agreements with customers and strategic partners often contain
terms  that  are  unique  to  that  customer  or  partner  and require extensive
negotiation.  As  a  result,  we  may  expend  substantial  funds  and effort to
negotiate  agreements  for  these  products,  but  may  ultimately  be unable to
consummate a sale of our products and services.



                                       11
<PAGE>

THE  LOSS  OF  THE  SERVICES OF, OR THE DEVELOPMENT OF SUBSTANTIAL EXTERNAL TIME
COMMITMENTS  BY,  OUR  SENIOR  MANAGEMENT  COULD  HAVE  A NEGATIVE EFFECT ON OUR
GROWTH.

     The  continued  growth  of  our  business is substantially dependent on the
performance  of  our senior management and key employees, especially those named
in  the  "Management"  section  of  this  prospectus.  We  carry key person life
insurance  on  only Dr. Titomirov, our Chief Executive Officer, and Dr. Babenko,
our  Chief  Technology  Officer. In addition, we have employment agreements with
only  Dr.  Babenko,  Mr.  Lehnen, our Chief Financial Officer, and Mr. Sullivan,
our  Senior  Vice  President of Marketing and Sales. The loss of the services of
any  member of our senior management or key personnel may significantly delay or
prevent  the  implementation  of our business strategy and could have a material
adverse effect on the growth of our business.

     Dr.  Titomirov  is  also  the  chairman and a significant stockholder of an
unrelated   company,  RealTimeHealth.com,  Inc.  ("RTH").  RTH  is  currently  a
development  stage  company  that  intends  to  allow  health  care consumers to
establish  individual  baseline  genetic  profiles  and  then monitor them for a
pattern  variance  over  time  through  the Internet. RTH intends to hire and is
currently   seeking   a   chief   executive  officer.  Dr.  Titomirov  currently
anticipates  that  his  duties as chairman of RTH will be limited to setting its
strategic  direction  and being involved in fundamental decisions and activities
of  the  board  of directors generally. In August 2000, we received a commitment
letter   regarding  the  continued  services  of  Dr.  Titomirov.  Although  Dr.
Titomirov's  commitment  letter  details  that  he currently intends to devote a
majority  of  his time to his duties as our Chief Executive Officer, there could
be  periods  where his activities with RTH substantially reduce the time devoted
to our operations.

WE  MAY  INCUR  SIGNIFICANT COSTS IN PROTECTING OUR INTELLECTUAL PROPERTY RIGHTS
OR RESPONDING TO CLAIMS OF INFRINGEMENT FROM OTHERS.

     We  currently  rely  upon a combination of trademark, patent, copyright and
trade  secret laws, employee and third party non-disclosure agreements and other
contracts  to  protect  our  proprietary  rights.  Nevertheless,  our efforts to
protect  our  intellectual  property  may  be inadequate and we may be unable to
prevent  others  from  offering  products  and services substantially similar to
ours.   We  also  need  to  secure  and  maintain  adequate  protection  of  our
intellectual  property  outside  of  the  United  States,  because our sales are
global.  The laws of some foreign countries do not protect proprietary rights to
the  same  extent  as the laws of the United States, and many companies engaging
in   international   business  have  encountered  considerable  difficulties  in
safeguarding their proprietary rights in foreign jurisdictions.

     Moreover,  third  parties  may claim that our current or future products or
services  infringe  upon  their  intellectual  property.  Litigation  over these
issues  could  be  a significant distraction and we may incur significant costs,
including  several  damages.  In the event that it is determined that one of our
products  infringe  upon  another's  proprietary  rights,  we may be required to
obtain  a  license  in  order to continue selling our products. That license may
not be available to us on favorable terms, or at all.

OUR  SOFTWARE  FACILITATES  RESEARCH  COLLABORATION  AND  THEREFORE  SECURITY IS
IMPORTANT  TO  OUR  CUSTOMERS.  WE  COULD  BE EXPOSED TO LIABILITY AND A LOSS IN
CUSTOMER CONFIDENCE IF OUR PRODUCTS FAIL TO PROVIDE THAT SECURITY.

     Our  software  facilitates  collaboration among researchers and the sharing
of  research  results. If there is a breach or failure of the security functions
in  our  software,  researchers'  proprietary  work  product  and  data  may  be
compromised  and  our customers would lose confidence in our software. We may be
exposed  to  considerable  liability from defects or breaches of security in our
products.

IF  WE  CANNOT EFFECTIVELY MANAGE OUR GROWTH, AND SPECIFICALLY THE TRANSITION OF
OUR  BUSINESS  RELATED  TO  AN  EMPHASIS ON THE SALE OF ENTERPRISE PRODUCTS, OUR
FUTURE PROSPECTS WOULD BE HARMED.


     In  recent years, we have experienced significant growth in the size of our
customer  base and the scope of our products and services. We also have expanded
and  intend  to  continue  to  expand  our  research  and  product  development,
marketing  and  sales,  and  professional  services organizations. These factors
have  placed, and will continue to place, a significant strain on our management
systems

                                       12
<PAGE>


and  resources.  As  a result of this offering, we will become a public company,
which  will  place  additional  strain  on  our  administrative,  financial  and
operational   systems.   Our   current  accounting  information  system  may  be
inadequate  to  support  our growth. Accordingly, we are presently transitioning
to  a  new  accounting  information  system.  Our  ability  to manage our growth
effectively  will  depend  upon the ability of our officers and key employees to
continue  to implement and improve our operational, administrative and financial
control  systems  and  to  expand, train and manage our workforce, and implement
necessary   changes   to  our  information  systems,  including  our  accounting
information system.

     Historically,  we  have  focused  on the development and sale of our Vector
NTI  Suite  of  desktop  products.  We  are currently seeking to increase market
penetration  and  brand  recognition of our GenoMax enterprise software platform
and,  accordingly are devoting an increasing portion of our resources to GenoMax
related  marketing  and  sales  and  professional  services  efforts. Failure to
successfully  manage  that transition effectively would materially and adversely
affect  nearly  every  aspect  of our business and cause our financial condition
and results of operations to suffer.

WE  SIGNIFICANTLY  DEPEND  UPON HOLDERS OF H-1B NON-IMMIGRANT VISAS TO STAFF OUR
RESEARCH  AND  PRODUCT DEVELOPMENT TEAM. OUR PRODUCT DEVELOPMENT AND ENHANCEMENT
EFFORTS  COULD BE HARMED IF WE ARE NOT ABLE TO ADEQUATELY STAFF OUR TEAM BECAUSE
OF THE LIMITATIONS OF U.S. IMMIGRATION LAWS.

     We  recruit professionals for our research and product development group on
an  international basis and, therefore, must comply with the immigration laws of
the  United  States.  Most  of  our  research  and  product development team are
citizens  of  other countries, with most of those working in the U.S. under H-1B
temporary  visas.  Under  the American Competitiveness and Workforce Improvement
Act  of  1988,  there is a statutory limit of 115,000 new H-1B visas that may be
issued  in fiscal year 2000 with such limit decreasing to 107,500 in 2001 and to
65,000  in  fiscal  year 2002 and thereafter. In any year in which this limit is
reached,  we may be unable to obtain a sufficient number of H-1B visas to employ
those  persons  we  would  like  to  add to our research and product development
group.  If  we  are  unable to obtain H1-B visas for our employees in sufficient
quantities  or  in  a  timely  manner,  our  product development and enhancement
efforts  could  be  hampered.  As a result, we may be unable to deliver products
that satisfy customer preferences and keep pace with technological change.

WE  INTEND  TO  CONSIDER  ACQUISITIONS OR STRATEGIC INVESTMENTS. WE HAVE LIMITED
EXPERIENCE  WITH  THESE  ACTIVITIES  AND  THE  COSTS AND DISTRACTIONS FROM THOSE
ACTIVITIES COULD HARM OUR FUTURE GROWTH.

     We  will  consider  acquiring  businesses, technologies or products that we
believe  are  a  strategic  fit with our business and strategy, although we only
have  limited  experience  with  these  activities. If appropriate opportunities
become  available, we could issue additional equity securities that would dilute
current  stockholders'  ownership,  or  incur  substantial  debt to finance such
transactions.  Methods  of  financing  any acquisitions or strategic investments
could  result  in  a  negative  impact  on  our financial condition. We may have
difficulties  integrating  the  businesses,  products, technologies or personnel
involved  in  any  acquisition  or strategic investment. Our integration efforts
may  result  in  significant expenditures of operating, financial and management
resources  that could materially and adversely affect our business. Acquisitions
involve  many  other  risks,  including  potential  loss  of  key  employees  or
customers,  the  assumption  of significant liabilities, and the amortization of
the  intangible  assets  of  acquired  companies. As a result of these and other
risks,  any acquisitions or strategic investments may ultimately have a negative
impact on our business, results of operation and financial condition.

DEFECTS  OR  MALFUNCTIONS  IN  OUR  SOFTWARE PRODUCTS, OR IN THE PRODUCTS OF OUR
TECHNOLOGY  PARTNERS, COULD HURT OUR REPUTATION AMONG CUSTOMERS AND EXPOSE US TO
LIABILITY.

     Our  business  and  the  level  of customer acceptance of our bioinformatic
software  products  are  dependent  upon  the continuous, effective and reliable
operation  of  our  computer  software and related tools and functions. Software
defects could occur in current or future products. To the extent that our


                                       13
<PAGE>


software  malfunctions  and  our  customers' use of our products is interrupted,
our  reputation  and  business could suffer. We may also be subject to liability
for  the  defects and malfunctions of third party technology partners and others
with whom our products and services interoperate.

WE  MAY  REQUIRE  ADDITIONAL  FUNDING  TO EXECUTE OUR BUSINESS STRATEGY. IF THAT
FUNDING  IS NOT AVAILABLE, OR NOT AVAILABLE ON TERMS ACCEPTABLE TO US, WE MAY BE
REQUIRED TO CURTAIL CERTAIN MARKETING AND PRODUCT DEVELOPMENT EFFORTS.

     We  expect  that  the  proceeds  from  this  offering,  our  cash flow from
operations  and  our  existing  capital resources will be sufficient to fund our
operations  for  the  next  24  months  but  it is possible that our growth will
require  us  to  seek  additional  financing  during this period. We may seek to
satisfy   any   additional  capital  needs  through  public  or  private  equity
offerings,  debt  financings  and  other  means. If we raise capital through the
issuance  of  additional  equity  securities, your ownership will be diluted. We
may  not  be  able  to obtain additional financing when we need capital on terms
favorable  to  us,  if  at  all.  If  we cannot obtain such financing, we may be
required  to  curtail our marketing and sales activities and product development
efforts.


                         RISKS RELATED TO OUR INDUSTRY


THE  BIOINFORMATIC  PRODUCTS  AND  SERVICES  MARKET IS INTENSELY COMPETITIVE AND
EVOLVING  AND  WE MAY NOT ACHIEVE OR MAINTAIN MARKET LEADERSHIP FOR A VARIETY OF
REASONS.

     We face, or expect to face, intense competition from:

     o third party commercial software vendors;

     o bioinformatics developers;

     o internal   bioinformatics  departments  of  some  of  our  customers  and
       potential customers;

     o organizations    engaging    in   the   provision   of   Internet-hosted,
       bioinformatic software; and

     o companies  facilitating Internet-based e-commerce between participants in
       our industry.

     We  believe  that  we  compete  most often with LION bioscience, NetGenics,
Compugen,  Genomica,  DNA  Star,  Rosetta  Inpharmatics,  DoubleTwist and GCG, a
division  of  Oxford  Molecular  being  sold  to Pharmacopeia. Others, including
large,  well-established software vendors, could readily enter this market. Many
of  our  competitors  have longer operating histories, stronger name recognition
and  significantly greater financial, technical and marketing resources than us.
As  a  result  of  these advantages, our competitors may be better able to adopt
more  aggressive pricing policies and better positioned to respond to changes in
customer preference or technology.

     To  remain  competitive,  we  believe  that  we must continue to expand and
enhance  the  functionality  of  our bioinformatic software products and respond
timely  and  effectively  to  evolving  industry  standards or technology. In an
intensely  competitive,  technology  driven  business  like  ours,  there  is no
certainty  that  market  leadership  can  be  obtained  or  maintained  for  any
sustainable period.

NUMEROUS  CUSTOMERS  AND  POTENTIAL CUSTOMERS FOR OUR BIOINFORMATIC SOFTWARE MAY
ELECT  TO  INTERNALLY  DEVELOP  OR  CONTINUE TO DEVELOP THEIR OWN SOFTWARE WHICH
COULD HURT OUR SALES EFFORTS.

     Our  customers  and potential customers, including providers of genomic and
proteomic  data,  may  elect  to internally develop or continue to develop their
own  bioinformatic  software.  Potential  customers  for  our  products  may  be
unwilling  to  abandon their prior internal efforts to look to an outside, third
party  source to provide their bioinformatic software solutions. As a result our
efforts to add new customers could be hampered.



                                       14
<PAGE>


IF  GROWTH  IN  THE  USE OF GENOMIC DATA DOES NOT OCCUR AS WE EXPECT, THE TARGET
MARKETS FOR OUR PRODUCTS AND SERVICES MAY NOT BE AS LARGE AS EXPECTED.

     The  application  of  genomic  information  to  pharmaceutical discoveries,
agricultural  production,  environmental  management and industrial processes is
an  evolving  and  unproven  practice.  Few  products  have  been  developed and
commercialized  resulting from recent genomic discoveries. If researchers do not
utilize  genomic  information  in their discovery and development efforts at the
level  we  project,  the  target  markets for our products and services will not
materialize and our prospects would be materially harmed.

OUR  SALE  OF  BIOINFORMATIC  PRODUCTS  AND  SERVICES  COULD SUFFER IF THERE ARE
REDUCTIONS   IN  CUSTOMER  RESEARCH  AND  DEVELOPMENT  EXPENDITURES  AND  PUBLIC
FUNDING.

     Sales  of  our products and services could suffer as a result of reductions
in  customer  research  and  development  expenditures  and  public funding. Our
continued  services  to  the  NCBI and sales of our products to other government
and  academic  institutions could be negatively affected by reductions in public
funding.

THE  PRODUCTS  AND  THE  ACTIVITIES  OF  OUR  CUSTOMERS,  INCLUDING THOSE IN THE
PHARMACEUTICAL   AND  BIOTECHNOLOGY  INDUSTRIES,  MAY  BE  SUBJECT  TO  CHANGING
REGULATION  THAT  COULD  ADVERSELY  AFFECT  GENOMIC  RESEARCH  AND REDUCE MARKET
DEMAND FOR OUR PRODUCTS.

     Because  our customers' products potentially touch on areas involving human
health,  they are affected by current or future government regulation, including
regulation  by  the  U.S.  Food  and  Drug Administration. Recently, the Clinton
administration  proposed  legislation regarding oversight of the sale of medical
products  over  the  Internet  and announced its intention to implement a set of
regulatory  initiatives  governing genetically engineered agricultural products.
In  addition,  numerous laws covering genetic testing of humans, the privacy and
security  of  human  genetic  information,  and  the storage and transmission of
individually  identifiable  health  care  information  have  been  introduced or
passed  at the state and federal levels. Our sales may indirectly be affected by
changes  in  government  regulation  covering our customers in these industries,
including  regulation  relating  to  drug development, genomic research, genetic
testing,  healthcare  reform and the sale of products and transfer of healthcare
data over the Internet.

     We  cannot  assure  you  that  customers  and  potential  customers for our
bioinformatic  software  products and related services will not curtail or defer
technology  investments  in  response  to  the  proposal or institution of these
governmental  efforts.  Moreover,  any  exposure by us to liability or increased
government  scrutiny  resulting  from regulatory or legal changes would distract
the  efforts  of  our  organization and require us to spend significant time and
resources  in connection with any resulting litigation or regulatory compliance.

OUR  BUSINESS  MAY  BE MATERIALLY AND ADVERSELY AFFECTED AS A RESULT OF ETHICAL,
LEGAL AND SOCIAL CONCERNS SURROUNDING THE USE OF GENOMIC INFORMATION.

     A  number  of  ethical, legal and social concerns, including issues related
to  privacy,  confidentiality  and  fairness,  have  arisen  as  a result of the
increased  availability  of genomic information. Government and private entities
are currently exploring issues, including:

     o ownership and control of genomic information;

     o definition of normal conditions, disabilities and disorders; and

     o determination of access  rights  to  resulting expensive technologies and
       responsibility for payment for treatment based on these technologies.

As  a  result  of  these  and  numerous  other ethical, legal and social issues,
government   authorities   may  limit,  or  increasingly  regulate  biomolecular
research   and   the   use  of  products  resulting  from  such  research.  Such
restrictions  could reduce the number of markets and potential customers for our
products and could materially and adversely affect our business.



                                       15
<PAGE>


CONSOLIDATION  WITHIN  THE  PHARMACEUTICAL AND BIOTECHNOLOGY INDUSTRIES MAY LEAD
TO  FEWER  CUSTOMERS FOR OUR PRODUCTS AND SERVICES. CONSOLIDATION COULD INCREASE
COMPETITION AND HARM OUR MARKETING AND SALES EFFORTS.

     A  significant  portion of our customer base consists of pharmaceutical and
biotechnology  companies.  Mergers  between  large  multinational pharmaceutical
companies  have  accelerated in recent years. Continued consolidation within the
pharmaceutical  and  biotechnology  industries may result in fewer customers for
our  products  and  services.  If one of the parties to a consolidation uses the
products  or  services  of  our competitors, we may lose existing customers as a
result of such consolidation.

WE  INTEGRATE THIRD PARTY DATABASES INTO OUR BIOINFORMATIC SOFTWARE PRODUCTS AND
MAY BE EXPOSED TO LIABILITY FOR CONTENT ERRORS IN THOSE DATABASES.

     Available  genomic,  proteomic  and  other  biomolecular  data  is vast and
complex,  and errors in databases containing this information are inevitable. We
integrate  data  housed  on  public  and  private  content  databases  into  our
bioinformatic  software  products.  We  could  be subject to claims of liability
associated  with  damages  resulting from any erroneous third party data that we
integrate  into  our  products or for which we facilitate delivery and analysis,
even if not integrated into our products.


                        RISKS RELATED TO THIS OFFERING

OUR COMMON STOCK MAY HAVE A VOLATILE TRADING PRICE AFTER THIS OFFERING.


     Prior  to  this  offering,  our  common stock has not been sold in a public
market.  You will pay a price that we negotiated with the representatives of the
underwriters  based  on  a number of factors. The price you pay for our stock in
this  offering  may  be  different  from  a  price  established in a competitive
market.  After  this  offering,  an active trading market in our stock might not
develop.  If  an  active  trading  market does develop, it may not continue. The
trading  price  of  our common stock may fluctuate widely as a result of a large
number  of  factors.  The  stock market has experienced extreme price and volume
fluctuations  that have affected the market prices of many companies involved in
the  software  and  biotechnology industries, which have often been unrelated to
the operating performance of these companies.

A  SIGNIFICANT  NUMBER  OF  OUR SHARES ARE ELIGIBLE FOR RESALE AFTER THE DATE OF
THE  OFFERING.  FUTURE  SALES  OF THESE SHARES MAY CAUSE THE MARKET PRICE OF OUR
COMMON STOCK TO FALL AND REDUCE OUR ABILITY TO RAISE CAPITAL.

     If  our existing stockholders sell substantial amounts of our common stock,
including  shares issuable upon the exercise of outstanding options or warrants,
or  if  the  market perceives that such sales may occur, the market price of our
common  stock may fall. After this offering, we will have outstanding 18,128,514
shares  of common stock. This includes the 5,000,000 shares of common stock that
we  are  selling  in  this offering and which may be resold in the public market
immediately.  This also includes approximately 13,128,514 shares of common stock
which  are  not  registered  but  which  are  eligible  for resale in the public
market,  subject  to  compliance  with Rule 144 or Rule 701 under the Securities
Act  of  1933,  as  amended.  While  the holders of          of these shares are
subject  to  lock-up  agreements  with  the underwriters in the offering for 180
days  after  the  date of the final prospectus for the offering, Bear, Stearns &
Co.  Inc.,  in  its  sole  discretion,  may  release any portion or all of these
shares  from  the  lock-up  restrictions.  In  addition,  sales of a substantial
number  of  shares  could  occur at any time after the expiration of the 180-day
period.   Holders   of  8,241,276  shares  of  our  common  stock,  or  warrants
exercisable  for  our common stock, are entitled to certain registration rights.
If  these holders, by exercising their registration rights, cause a large number
of  shares  to  be  registered  and sold in the public market, these sales could
cause  a decline in the market price of our common stock. If we were to include,
in  a  registration  statement  initiated by us, shares held by these holders in
accordance  with  their  registration  rights,  the inclusion of such shares may
reduce our ability to raise capital.



                                       16
<PAGE>

OUR  EXECUTIVE  OFFICERS  AND  DIRECTORS  AND  THEIR AFFILIATES WILL OWN A LARGE
PERCENTAGE  OF OUR COMMON STOCK FOLLOWING THE OFFERING AND WILL HAVE THE ABILITY
TO INFLUENCE DECISIONS THAT COULD ADVERSELY AFFECT OUR STOCK PRICE.


     Following   the  completion  of  this  offering,  our  executive  officers,
directors  and  their affiliates will own approximately 60.3% of the outstanding
shares  of  common  stock.  As  a  result,  these  stockholders  will be able to
substantially   influence   all  matters  requiring  stockholder  approval  and,
thereby,  our  management  and  affairs.  Matters  that will require stockholder
approval include:


     o election of directors;

     o approval of certain mergers or consolidations;

     o sale of all or substantially all of our assets; and

     o issuance  of  large  amounts  of  our  shares  in private transactions or
       acquisitions.

     This  concentration  of  ownership  may  delay,  deter or prevent acts that
would  result  in a change of control of our company, which in turn could reduce
the  market  price  of our common stock. This concentration may also prevent new
investors from influencing significant corporate decisions.

INVESTORS  PARTICIPATING IN THIS OFFERING WILL INCUR IMMEDIATE DILUTION OF THEIR
COMMON STOCK BASED ON ITS BOOK VALUE AFTER THE OFFERING.


     The  offering  price  will  be  substantially higher than the pro forma net
tangible  book  value  of  our  common stock as of June 30, 2000. At the assumed
initial  public offering price of $15.00 per share, the midpoint of the offering
range,  the  pro forma net tangible book value of the common stock will be $4.41
per  share.  This  represents an immediate and substantial dilution per share of
$10.59  for investors purchasing shares in this offering. The dilution per share
represents  the  difference  between the amount per share paid by the purchasers
of  shares  of common stock in this offering and the pro forma net tangible book
value  per  share  of  common  stock  immediately  after  the completion of this
offering.  In  addition,  to  the  extent  outstanding  options  or warrants are
exercised, there will be further dilution to new investors.


OUR   CHARTER  AND  BYLAWS  AND  DELAWARE  LAW  CONTAIN  PROVISIONS  THAT  COULD
DISCOURAGE A TAKEOVER EVEN IF BENEFICIAL TO STOCKHOLDERS.

     Our  charter  and  our  bylaws,  and  portions  of  Delaware  law,  contain
provisions  that  could  make  it  more  difficult  for  a third party to obtain
control  of  InforMax, even if doing so would be beneficial to stockholders. For
example,  our  amended and restated certificate of incorporation to be effective
upon  the closing of this offering provides for a classified board of directors,
allows  the board of directors to expand its size and fill any vacancies without
stockholder  approval,  and  allows the board of directors to classify and issue
preferred  stock  without  stockholder approval. Our bylaws restrict the ability
of  stockholders  to  call  a  special  meeting  and  require  advance notice of
stockholder  proposals. Delaware law makes it difficult for us to be acquired by
a  significant  stockholder  that  is  not  approved  in advance by our board of
directors.

WE  WILL  RETAIN BROAD DISCRETION IN THE USE OF THE NET PROCEEDS WE RECEIVE FROM
THIS  OFFERING  AND  MAY  SPEND  A  SUBSTANTIAL  PORTION  IN WAYS WITH WHICH YOU
DISAGREE.


     We  will  retain a significant amount of discretion over the use of our net
proceeds  from  this  offering,  as well as over the timing of our expenditures.
Because  of the number and variability of factors that will determine our use of
the  net  proceeds,  we  may  apply  the  net  proceeds  in  ways with which you
disagree.



                                       17
<PAGE>

               SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS


     We  make statements in this prospectus that are forward-looking statements.
These  statements  are subject to risks and uncertainties. These forward-looking
statements  are  generally accompanied by words such as "may," "will," "intend,"
"anticipate,"  "believe,"  "estimate," "expect," "should" or similar expressions
or  the  negative  of the expressions. These statements are only predictions and
actual  events  or  results  may differ materially. Although we believe that the
expectations  reflected  in  the  forward-looking  statements are reasonable, we
cannot   guarantee   future   results,   levels   of  activity,  performance  or
achievements.  You  should  understand that these forward-looking statements are
subject  to  a  number  of assumptions, risks and uncertainties that could cause
our  actual  results to differ materially from those expressed or implied in the
forward-looking  statements.  Important  factors that could cause actual results
to  differ  materially  from  the  estimates  or  projections  we  make  in  our
forward-looking  statements  include those described in "Risk Factors." In light
of  the  risks  we  describe  in  "Risk  Factors," the forward-looking events we
discuss  in  this  prospectus  may  not  occur.  Except  for  duties  imposed by
applicable  law,  we  do  not  intend  to  publicly  update or revise any of the
forward-looking statements in this prospectus.

                               ----------------

     The  marks  InforMax  &  Double  Helix  Design  and  Vector NTI, AlignX and
BioPlot  are registered trademarks of InforMax, Inc. InforMax, InforMax's Double
Helix   Logo   Design,  GenoMax,  ContigExpress,  High-Throughput  Research  and
Software  Solution  for  Bio-Medicine, are each trademarks of InforMax, Inc. and
U.S.  trademark applications for these marks have been filed. Vector Enterprise,
Vector  NTI  Suite,  Dynamic  License Server Research Logic and Research Logic &
Design  are trademarks of InforMax, Inc. All other product, service, and company
names contained in this prospectus are trademarks of other parties.



                                       18
<PAGE>


                                USE OF PROCEEDS

     We estimate  that we will  receive net proceeds  from this  offering of our
common stock of approximately  $68,550,000 , or approximately $79,012,500 if the
underwriters' over-allotment option is exercised in full. This estimate is based
on an assumed initial public  offering price of $15.00 per share,  the mid-point
of the offering  range,  and deducts the  estimated  underwriting  discounts and
commissions and our estimated offering expenses.

     The  principal  purposes  of  this offering are to provide working capital,
create  a  public  market  for our common stock, facilitate our future access to
the  public  capital  markets  and  increase  our  visibility in our markets. We
anticipate  that,  subject  to the availability of opportunities on terms and at
prices  we  deem  acceptable,  we would allocate as much as 80% and as little as
20%  of  the  net  proceeds to expanding our business through the acquisition of
additional  businesses,  products  and  technologies  and  to establishing joint
ventures  or  other  collaborative  arrangements which we believe complement our
current  or  future  business.  We  anticipate that the remaining portion of the
offering  proceeds  would  be  allocated  approximately  one-third  to expanding
research  and  development,  approximately  one-third  to  expanding  sales  and
marketing  and  approximately one-third to working capital and general corporate
purposes.  We  have  no  specific  plans,  agreements  or commitments to use the
proceeds  for  any specific acquisition or collaborative arrangement and, to the
extent  appropriate  opportunities are not available, all proceeds not allocated
to  external expansion would be applied to internal expansion, through expanding
our  research  and  development  and  our  sales  and  marketing efforts, and to
working  capital  and  general  corporate purposes. The amounts that we actually
expend  for  the purposes above will vary significantly depending on a number of
factors,  including  future  revenue  growth,  if any, and the amount of cash we
generate  from  operations.  As a result, we will retain broad discretion in the
allocation  of  the net proceeds of this offering. Until we use the net proceeds
of  this  offering,  we  intend  to invest them in U.S. government securities or
investment-grade, interest-bearing instruments.

     We  expect  that  the  net  proceeds  from  this  offering,  cash flow from
operations  and  our  existing  capital resources will be sufficient to fund our
operations  for  the  next  24  months,  but it is possible that our growth will
require us to seek additional financing during this period.



                                DIVIDEND POLICY

     We  have  never  declared  or  paid  any  dividends on our common stock. We
expect  to  retain  all  earnings,  if  any, generated by our operations for the
development  and  growth of our business. We do not intend to pay cash dividends
on  our common stock for the foreseeable future. However, our board of directors
is  free to change our dividend policy in the future, based upon factors such as
our  results  of  operations,  financial  condition,  cash  flow, cash needs and
future  prospects. If our board of directors were to change our dividend policy,
so  long  as we have any amount outstanding under our credit facilities with PNC
Bank,  National  Association,  we would be required to obtain PNC Bank's written
consent prior to the declaration or payment of such dividends.


                                       19
<PAGE>

                                CAPITALIZATION


     The following table shows our capitalization as of June 30, 2000:

     o on an actual basis;

     o on a pro  forma  basis  to  give  effect  to  the  issuance  of  Series B
       convertible preferred stock after June 30, 2000, the automatic conversion
       of all redeemable  convertible preferred stock into common stock upon the
       closing of this offering, and the conversion of the outstanding nonvoting
       common stock into shares of voting  common stock upon the closing of this
       offering;

     o on a pro forma basis as adjusted to give effect to the issuance of Series
       B  convertible  preferred  stock  after  June  30,  2000,  the  automatic
       conversion  of all  redeemable  convertible  preferred  stock into common
       stock  upon the  closing  of this  offering,  and the  conversion  of the
       outstanding  nonvoting  common  stock into shares of voting  common stock
       upon the closing of this  offering;  and our receipt of the estimated net
       proceeds  from the  sale of 5,000,000  shares  of  common  stock in this
       offering at an assumed initial public offering price of $15.00 per share,
       after  deducting  estimated  underwriting  discounts and  commissions and
       estimated offering expenses.



<TABLE>
<CAPTION>
                                                                                        AS OF JUNE 30, 2000
                                                                          -----------------------------------------------
                                                                                            (UNAUDITED)
                                                                                                             PRO FORMA
                                                                               ACTUAL        PRO FORMA      AS ADJUSTED
                                                                          --------------- --------------- ---------------
<S>                                                                       <C>             <C>             <C>
Long-term debt ..........................................................  $  1,241,973    $  1,241,973    $  1,241,973
Series A redeemable convertible preferred stock, par value $0.01 --
 2,161,265 shares authorized, issued, and outstanding, actual, and
 2,161,265 shares,  authorized, no shares issued or
 outstanding pro forma and pro forma as adjusted ........................     4,263,194              --              --
                                                                           ------------    ------------    ------------
Series B redeemable convertible preferred stock, par value $0.01 --
 950,747 shares authorized, issued and outstanding actual,
 pro forma and  pro forma as adjusted ..........................                     --              --              --
                                                                           ------------    ------------    ------------
Stockholders' equity (deficit):
 Preferred stock, par value $0.01, 20,000,000 shares authorized, no
   shares issued or outstanding, actual, pro forma and pro forma as
   adjusted .............................................................            --              --              --
 Common stock - voting, par value $0.001; 100,000,000 shares
   authorized, 2,254,500 shares issued and outstanding, actual;
   12,983,068 shares issued and outstanding, pro forma;
   17,983,068 shares issued and outstanding,
   pro forma as adjusted ................................................         2,255          12,983          17,983
 Common stock - nonvoting, par value $0.001; 24,936,212 shares
   authorized, 5,531,508 issued and outstanding, actual; no shares
   issued and outstanding, pro forma; and pro forma as adjusted .........         5,531              --              --
Subscription receivable .................................................    (1,013,436)     (1,013,436)     (1,013,436)
Additional paid-in capital ..............................................     6,260,877      20,518,874      89,063,874
Deferred compensation ...................................................      (461,734)       (461,734)       (461,734)
Accumulated deficit .....................................................    (8,242,199)     (8,242,199)     (8,242,199)
                                                                           ------------    ------------    ------------
    Total stockholders' equity (deficit) ................................    (3,448,706)     10,814,488      79,364,486
                                                                           ------------    ------------    ------------
Total capitalization ....................................................  $  2,056,461    $ 12,056,461    $ 80,606,461
                                                                           ============    ============    ============
</TABLE>



     In  addition  to  the  shares  of  common stock to be outstanding after the
offering,  we  may  issue  additional shares of common stock under the following
plans and arrangements:
   o 13,425,125  shares  issuable upon exercise of outstanding options including
     4,990,345  issued  under  our  equity  incentive  compensation  plan  at  a
     weighted average exercise price of $0.622 per share as of June 30, 2000;
   o 1,356,494  shares  available for future issuance under our equity incentive
     compensation plan; and
     o 40,080 shares issuable upon exercise of outstanding warrants

Please  read  the  capitalization table together with our consolidated financial
statements  and  related notes and with the sections of this prospectus entitled
"Selected   Financial   Data"  and  "Management's  Discussion  and  Analysis  of
Financial  Condition  and  Results  of  Operations"  included  elsewhere in this
prospectus.



                                       20
<PAGE>

                                   DILUTION


     Our  pro  forma  net  tangible  book  value  as  of June 30, 2000 was $10.8
million,  or $0.83 per share of common stock. We have calculated this amount by:

     o subtracting our total liabilities from total tangible assets; and

     o then dividing the  difference  by the total pro forma number of shares of
       common stock outstanding,  including the number of shares of common stock
       that will be  issued  upon the  automatic  conversion  of all  redeemable
       convertible preferred stock, including the Series B Convertible Preferred
       Stock issuance after June 30, 2000, upon the completion of this offering.

     After  giving effect to the sale of 5,000,000 shares of our common stock in
this  offering  and deducting the underwriting discounts and commissions and the
estimated  offering  expenses payable by us, our adjusted pro forma net tangible
book  value  as  of  June  30,  2000 would have been $79.4 million, or $4.41 per
share.  This  amount represents an immediate dilution of $10.59 per share to new
investors. The following table illustrates this per share dilution:


<TABLE>

<S>                                                                      <C>          <C>
Initial public offering price per share ..............................                 $  15.00
                                                                                       --------
 Pro forma net tangible book value per share before this offering.....    $  0.83
 Increase in pro forma net tangible book value per share
   attributable to new investors .....................................       3.58
                                                                          -------
Pro forma net tangible book value per share after this offering ......                     4.41
                                                                                       --------
Dilution per share to new investors ..................................                 $  10.59
                                                                                       ========

</TABLE>



     The  following table summarizes on a pro forma basis after giving effect to
the  offering,  as  of  June  30,  2000,  the  differences  between the existing
stockholders  and  new  investors with respect to the number of shares of common
stock  purchased  from  us,  the  total consideration paid to us and the average
price  per  share  paid before deducting estimated discounts and commissions and
estimated offering expenses payable by us:



<TABLE>
<CAPTION>
                                                                                           AVERAGE PRICE
                                           SHARES                      TOTAL                PER COMMON
                                         PURCHASED                 CONSIDERATION               SHARE
                                  ------------------------   --------------------------   --------------
                                     NUMBER       PERCENT        AMOUNT        PERCENT
                                  ------------   ---------   -------------   ----------
<S>                               <C>            <C>         <C>             <C>          <C>
Existing stockholders .........   12,983,068        72.2%    $4,891,717           6.1%       $  0.38
New investors .................    5,000,000        27.8     75,000,000          93.9        $ 15.00
                                  ----------       -----     ----------         -----        -------
 Total ........................   17,983,068       100.0%    79,891,717         100.0%
                                  ==========       =====     ==========         =====

</TABLE>



     If  the  underwriters  exercise  their over-allotment option in full, there
will  be  an increase in pro forma net tangible book value of $4.80 per share to
existing  stockholders  and an immediate dilution in pro forma net tangible book
value  of $10.20 to new investors. Our existing stockholders would own 69.3% and
our  new  public  investors would own 30.7% of the total number of shares of our
common stock outstanding after this offering.

     The  foregoing  discussion  and  tables are based upon the number of shares
actually  issued  and  outstanding  on  June  30, 2000 and assume no exercise of
options  or  warrants  outstanding  as  of June 30, 2000. As of that date, there
were  13,425,125  shares  issuable  upon  exercise  of  options outstanding at a
weighted  average  exercise  price  of  $0.622 per share as of June 30, 2000 and
40,080 shares issuable upon exercise of warrants outstanding.


     To  the  extent that these or any other outstanding options or warrants are
exercised, there will be further dilution to new investors.

                                       21
<PAGE>

                     SELECTED CONSOLIDATED FINANCIAL DATA

     You  should read our selected consolidated financial data together with our
consolidated   financial   statements   and   their   related   notes  and  with
"Management's  Discussion  and  Analysis  of  Financial Condition and Results of
Operations,"  which  we  have  included  elsewhere  in  this prospectus. We have
derived  the statement of operations data for the years ended December 31, 1997,
1998  and  1999 and the balance sheet data as of December 31, 1998 and 1999 from
our  audited  consolidated  financial  statements  included  elsewhere  in  this
prospectus.  These  consolidated  financial  statements  have  been  audited  by
Deloitte  & Touche LLP. We have derived the statement of operations data for the
years  ended  December  31,  1995  and  1996  from  our  unaudited  consolidated
financial  statements  that  are  not  included  in this prospectus. The balance
sheet  data  as  of  December  31,  1995 and 1996 are derived from our unaudited
consolidated  financial statements that are not included in this prospectus. The
balance  sheet  data  as  of  December  31,  1997  are  derived from our audited
consolidated financial statements that are not included in this prospectus.


     We  have  derived  the  statement  of  operations data for the three months
ended  June  30,  1999  and  2000 and the balance sheet data as of June 30, 2000
from  our  unaudited consolidated financial statements, which have been prepared
on   substantially   the  same  basis  as  the  audited  consolidated  financial
statements   and,  in  the  opinion  of  management,  include  all  adjustments,
consisting   only   of  normal  recurring  adjustments,  necessary  for  a  fair
presentation of the results of operations for these periods.


     The  historical  results  presented below are not necessarily indicative of
future results.


<TABLE>
<CAPTION>
                                                                                                        SIX MONTHS ENDED
                                                              YEAR ENDED DECEMBER 31,                       JUNE 30,
                                               ----------------------------------------------------- -----------------------
                                                1995      1996       1997       1998         1999       1999        2000
                                               ------ ----------- --------- ------------ ----------- --------- -------------
                                                                                                           (UNAUDITED)
                                                       (IN THOUSANDS EXCEPT PER SHARE DATA)
<S>                                            <C>    <C>         <C>       <C>          <C>         <C>       <C>
STATEMENT OF OPERATIONS DATA:
Revenues:
 Software license and customer support .......  $166    $ 382      $1,335      $2,732     $  7,277    $3,322     $ 4,855
 Professional services .......................   403      636         867      1,394         2,737     1,159       1,655
                                                ----    -----      ------      ------     --------    ------     -------
   Total revenues ............................   569    1,018       2,202      4,126        10,014     4,481     $ 6,510
Cost of revenues:
 Software license and customer support .......     8       19          38        190           405       146         233
 Professional services (1) ...................   156      309         716      1,081         1,612       731         880
                                                ----    -----      ------      ------     --------    ------     -------
   Total cost of revenues ....................   164      328         754      1,271         2,017       877       1,113
Gross profit .................................   405      690       1,448      2,855         7,997     3,604       5,397
Operating expenses:
 Selling, general and administrative (2) .....   195      507       1,075      2,476         7,000     2,397       7,565
 Research and development (3) ................   165      161         365      1,162         2,597     1,129       2,471
 Stock based compensation ....................    22       --         211         18           138        27         975
 Depreciation and amortization ...............    --        3          18         94           273        89         343
                                                ----    -----      ------      ------     --------    ------     -------
   Total operating expenses ..................   382      671       1,669      3,750        10,008     3,642      11,354
Income (loss) from operations ................    23       19        (221)      (895)       (2,011)      (38)     (5,957)
Other income (expense):
 Investment earnings .........................    --       --          --         --            66         2          16
 Interest expense ............................    --         (4)      (19)       (60)          (86)      (33)       (120)
 Other .......................................    --       --         (12)          (3)        (10)       --            (8)
                                                ----    -------    ------      --------   --------    ------     ----------
   Total other income (expense) ..............    --         (4)      (31)       (63)          (30)      (31)       (112)
Income (loss) before income taxes ............    23       15        (252)      (958)       (2,041)      (69)     (6,069)
Income tax expense (benefit) .................     1       11        (118)      (391)         (726)       13          --
                                                ----    -------    ------      -------    --------    ------     ---------
Net income (loss) ............................  $ 22    $   4      $ (134)     $(567)     $ (1,315)   $  (82)    $(6,069)
</TABLE>


                                       22
<PAGE>



<TABLE>
<CAPTION>
                                                                                                          SIX MONTHS ENDED
                                                             YEAR ENDED DECEMBER 31,                          JUNE 30,
                                              ------------------------------------------------------ --------------------------
                                                 1995     1996     1997       1998         1999          1999         2000
                                              ---------- ------ ---------- ---------- -------------- ----------- --------------
                                                                                                            (UNAUDITED)
                                                       (IN THOUSANDS EXCEPT PER SHARE DATA)
<S>                                           <C>        <C>    <C>        <C>        <C>            <C>         <C>
Accretion of transaction costs on
 redeemable convertible preferred stock .....       --     --         --         --             (8)         --             (8)
Accrued dividend on redeemable
 convertible preferred stock ................       --     --         --         --         (168)           --         (160)
Net income (loss) applicable to common
 shares .....................................   $   22    $ 4    $  (134)   $  (567)     $(1,491)      $   (82)     $(6,237)
                                                ======    ===    =======    =======      =========     =======      =========
Basic net (loss) applicable per common
 share ......................................   $ 0.01    $--    $ (0.04)   $ (0.16)     $ (0.38)      $ (0.02)     $ (1.48)
                                                ======    ===    =======    =======      =========     =======      =========
Diluted net income (loss) applicable per
 common share ...............................   $ 0.01    $--    $ (0.04)   $ (0.16)     $ (0.38)      $ (0.02)     $ (1.48)
                                                ======    ===    =======    =======      =========     =======      =========
</TABLE>



----------
(1) Cost  of  revenues - professional services includes stock based compensation
    of  $-0-,  $-0-,  $105,539,  $-0-, $-0-, $-0- and $5,497 for the years ended
    December  31,  1995,  1996, 1997, 1998, 1999 and the six month periods ended
    June 30, 1999 and 2000, respectively.

(2) Selling,   general   and   administrative   expense   excludes  stock  based
    compensation   of   $21,916,  $-0-,  $76,189,  $-0-,  $111,019,  $9,643  and
    $845,741  for  the years ended December 31, 1995, 1996, 1997, 1998, 1999 and
    the six month periods ended June 30, 1999 and 2000, respectively.

(3) Research  and development expense excludes stock based compensation of $-0-,
    $-0-,  $134,506,  $17,782, $27,166, $16,748 and $128,874 for the years ended
    December  31,  1995,  1996, 1997, 1998, 1999 and the six month periods ended
    June 30, 1999 and 2000, respectively.



<TABLE>
<CAPTION>
                                                                    AS OF DECEMBER 31,                     AS OF JUNE 30,
                                                   ----------------------------------------------------   ---------------
                                                    1995     1996      1997        1998         1999            2000
                                                   ------   ------   --------   ---------   -----------   ---------------
                                                                                                            (UNAUDITED)
                                                                      (IN THOUSANDS)
<S>                                                <C>      <C>      <C>        <C>         <C>           <C>
BALANCE SHEET DATA:
Cash and cash equivalents ......................    $ 16     $ 35     $  382     $  296      $  1,399        $  2,091
Working capital (deficit) ......................      72       62        371       (419)        1,040          (1,283)
Total assets ...................................     114      250      1,114      2,883         7,265          10,109
Capital lease obligations, less current
 portion .......................................      --        8         55        182            92              49
Equipment loan facility, less current
 portion .......................................      --       --         --         --           623           1,242
Total liabilities ..............................      38      174        974      3,288         4,887           9,295
Redeemable convertible preferred stock .........      --       --         --         --         4,095           4,263
Common stock and additional paid-in
 capital .......................................     233      233        550        588           975           6,269
Stockholders' equity (deficit) .................      76       76        139       (405)       (1,717)         (3,449)
</TABLE>


     See  our  consolidated financial statements and notes included elsewhere in
this  prospectus  for a description of the computation of the historical and pro
forma  net  loss  per  share and the number of shares used in the historical and
pro forma per share calculations in statement of operations data above.


                                       23
<PAGE>

                    MANAGEMENT'S DISCUSSION AND ANALYSIS OF
                 FINANCIAL CONDITION AND RESULTS OF OPERATIONS


     The  following  is a discussion of our consolidated financial condition and
results  of  operations.  You  should  read  this  discussion  together with our
consolidated  financial statements and the related notes, which we have included
elsewhere  in this prospectus. We make some forward-looking statements about our
future  performance. These forward-looking statements include numerous risks and
uncertainties,  such  as  those  described in the "Risk Factors" section of this
prospectus, and accordingly our actual results may differ materially.

OVERVIEW

     We  are  a leading global provider of bioinformatic software solutions. Our
bioinformatic  software  enables  the  analysis  and  interpretation of genomic,
proteomic  and  other  biomolecular  data that form the genetic blueprint of all
living  organisms.  Since  beginning  commercial  operations  in  1993,  we have
dedicated  substantial  resources  to  expand  and  enhance our software product
lines,  increase  our sales and marketing efforts, and enlarge and diversify our
customer base.

     In  1993,  we commercially released our first desktop software product, the
current  version  of  which  is marketed as our Vector NTI Suite 6.0 for desktop
computers.  In  September  1998,  we commercially released our Software Solution
for  Bio-Medicine enterprise computing platform, the current version of which is
marketed as GenoMax 2.5.

     To  date,  we  have  sold  over 20,000 licenses for our Vector NTI Suite of
software  applications  for  desktop  computers  and 18 licenses for our GenoMax
enterprise  platform for a network of computers linked together for sharing data
and  computation. Our customer base includes over 1,300 organizations worldwide,
including  over 500 biotechnology, pharmaceutical and agricultural biotechnology
and  life  science  companies  and  over  800  academic  and government research
institutions.  In  1999, our 10 largest customers accounted for less than 37% of
our total software license revenues.

     In  August  2000,  we  entered  into  a strategic partnership with Amersham
Pharmacia  Biotech  to jointly develop and market an expanded version of GenoMax
to   provide   an   enterprise-wide  data  analysis  system  for  pharmaceutical
companies,  for  integrating  and  analyzing  data from genomics, proteomics and
drug  screening  production  laboratories.  In connection with this partnership,
Amersham  purchased  950,747  shares  of our preferred stock in exchange for $10
million in cash.

     Our  revenue  has  increased substantially in recent years. Revenue for the
year  ended December 31, 1999 represents a four-year compound annual growth rate
of  105%  and  a 143% increase over the prior year. We provide sales, marketing,
implementation  and  support services for our products. Our Vector NTI Suite and
GenoMax  software  products  are  considered off-the-shelf products that require
only routine installation to be fully functional by the end user.

     We  currently  generate  revenues  from software sales and software-related
professional   services.  Software  sales  consist  of  software  license  fees,
maintenance  fees,  and  related  customer  training. Professional services have
historically   consisted   of   software  development  services  provided  under
contracts  to  the  National  Center for Biotechnology Information (NCBI) at the
National  Institutes  of  Health  and  beginning  in  2000  have  also  included
customer-specified   software   installation,   integration   and  customization
services  related  to  our  commercial  software  products.  NCBI  contracts for
professional  services  through  intermediaries  for  whom  InforMax serves as a
subcontractor.  These  agreements  may  be  terminated  on behalf of NCBI at any
time.

     We  expect to generate future revenues from our channeling and distribution
alliances   and   from   e-commerce   offerings.  Channeling  alliances  include
agreements   with   data  content  providers  to  integrate  their  biomolecular
databases  with  our  software  products  and  to  resell subscriptions to these
databases  to  our  customers.  Distribution  alliances  include agreements with
providers  of  specialized  bioinformatic hardware to integrate and resell their
hardware  with  our software products. Under our content channeling and hardware
distribution  alliances,  we  intend  to generate transaction fees and realize a
portion  of  the  revenues  for the products we resell. To date, we have entered
into  four agreements to resell third party data content or technology hardware.
E-commerce  offerings  will  include  incorporating Internet hyperlinks into our
Vector NTI Suite and entering into related


                                       24
<PAGE>


partnerships  with  laboratory  reagent  vendors to generate transaction fees on
sales  we  facilitate.  For  additional information regarding our channeling and
distribution  alliances  and  our e-commerce offerings please refer to "Business
-- Our Product and Service Lines."

     We   recognize  software  license  revenues  based  on  the  provisions  of
Statement  of  Position  ("SOP")  No.  97-2,  Software  Revenue  Recognition, as
amended  by  SOP No. 98-4 and SOP No. 98-9. Software license fees are recognized
as  revenue  upon the customer's execution of a non-cancelable license agreement
and  delivery  of  the  software,  provided  that  the  license fee is fixed and
determinable,  collectibility  is probable, and no customization of the software
is  required.  In  connection  with  our  software  licenses, we also enter into
maintenance   contracts   that   provide  for  technical  support  and  periodic
unspecified upgrades.

     During  1997  and 1998, we recognized maintenance revenue together with the
initial  licensing  fee  upon delivery of the software when all of the following
were met:

     o the maintenance fee was included with the initial licensing fee,

     o the maintenance revenue to be recognized was for one year or less,

     o the  estimated  cost  of providing maintenance during the arrangement was
       insignificant, and

     o any unspecified upgrades were expected to be minimal.

In  circumstances  where  these  criteria  were  not  met and the fair value for
undelivered  elements  of  a  multiple  element  contract were not determinable,
revenue  on  the  contract  was  entirely  deferred  until either fair value was
determinable  or  when  all  elements  were  delivered.  If  we  were  unable to
establish  vendor  specific  objective evidence of fair value on the undelivered
elements  and the only undelivered element was maintenance, then all revenue was
recognized ratably over the maintenance period.

     Due  to  the introduction of new modules, product enhancements, and product
versions,  we  increased  our  maintenance  support  staff and, as a result, the
estimated  cost of providing maintenance services to our customers was no longer
deemed  insignificant.  Therefore,  beginning in January 1999, revenues from all
software  maintenance contracts were unbundled from software licenses based upon
vendor  specific  objective  evidence  of fair value and recognized ratably over
the  maintenance  period.  Vendor  specific  objective  evidence for maintenance
contracts  is  determined  by  the list price established by management with the
relevant  authority or by the renewal rate specified in the contract. We use the
residual  method to recognize revenue on delivered elements when vendor specific
objective  evidence  of  fair  value  has  been  determined  for all undelivered
elements.  Discounts,  if  any,  are  applied  to  the delivered elements if the
residual  method  is  used.  Amounts  received  in  advance  of  the delivery of
products or performance of services are classified as deferred revenues

     Training  is  provided on a daily fee basis and we recognize revenue as the
services are provided.

     Beginning   in   2000,   we   have   provided  customer-specified  software
installation,  integration  and customization services related to our commercial
software  products  on  a  time and materials basis and recognize revenue as the
services  are  provided.  During  1997,  1998 and 1999 our professional services
revenue  was  derived  from  contracts  related to software development services
provided    to    NCBI   under   time   and   materials   subcontracts   and   a
cost-plus-fixed-fee    subcontract.    During   1999   the   cost-plus-fixed-fee
subcontract  was  converted upon its renewal to a time and material contract. We
recognize  revenue  under the time and material subcontracts as the services are
provided   based  upon  contractual  rates.  We  recognized  revenue  under  the
cost-plus-fixed-fee  subcontract as recoverable costs were incurred, including a
proportionate amount of the fixed fee.

     Our  quarterly  operating  results  have  historically  fluctuated  and  we
anticipate  such  results  to  continue to fluctuate significantly. Factors that
may   cause   our   quarterly  results  to  fluctuate  include  the  timing  of,
commencement, delay, cancellation or completion of our:

     o software licensing agreements;

     o product delivery schedules;


                                       25
<PAGE>


     o strategic relationships; and

     o professional  service  activities,  including  installation  and software
       modification.

Our  results  of  operations  may  also  fluctuate as a result of the number and
timing  of  orders  for  our  GenoMax  enterprise  product,  which  can  have  a
significant effect on revenues for a particular quarter.

     The  manner in which we recognize revenue, in accordance with the generally
accepted  accounting  principles, may also cause our quarterly operating results
to  fluctuate  substantially.  In  accordance  with  these principles, we may be
required  to  defer  all  or  a portion of the revenue from some of our software
licenses  sold  in  a particular quarter to a later quarter. Expenses associated
with  software  licenses  are  not  typically  so  deferred. For our maintenance
contracts  and  professional  services, we typically recognize revenues over the
term of the contract.

     As  a  result  of  the  academic  calendar, European business practices and
commercial   information   technology   procurement   practices,   we  generally
experience  a  reduction  in  sales  in  the third quarter of each calendar year
which  typically results in a corresponding reduction in operating revenues. Due
to  the  factors  described  above and other risks discussed in this prospectus,
you  should  not  rely  upon  quarterly  comparisons of our financial results as
these  comparisons  are  not  necessarily  meaningful  nor  are  they a reliable
indicator of our future performance.


RESULTS OF OPERATIONS


     The  following  table sets forth our audited consolidated operating results
for  the  years  ended  December  31, 1997, 1998 and 1999, and for the unaudited
six-month  periods  ended  June  30, 1999 and 2000, as a percentage of our total
revenue for the respective periods.



<TABLE>
<CAPTION>
                                                                                                SIX MONTHS ENDED
                                                           YEAR ENDED DECEMBER 31,                  JUNE 30,
                                                   ---------------------------------------   -----------------------
                                                       1997          1998          1999         1999         2000
                                                   -----------   -----------   -----------   ----------   ----------
                                                                                                   (UNAUDITED)
<S>                                                <C>           <C>           <C>           <C>          <C>
Revenues
 Software license and customer support .........       61%            66%           73%         74%           75%
 Professional services .........................       39             34            27          26            25
                                                       ----           ---           ---         ---           --
   Total revenues ..............................       100           100           100          100          100
Cost of revenues:
 Software license and customer support .........        2              5             4           3             4
 Professional services .........................       32             26            16          17            14
                                                       ----          ----          ----         ---          ---
   Total cost of revenues ......................       34             31            20          20            18
Gross profit ...................................       66             69            80          80            82
Operating expenses
 Selling, general and administrative ...........       49             60            70          53           116
 Research and development ......................       16             29            26          25            38
 Stock based compensation ......................       10             --             1           1            15
 Depreciation and amortization .................        1              2             3           2             5
                                                       ----          ----          ----         ---          ---
   Total operating expenses ....................       76             91           100          81           174
Loss from operations ...........................       (10)          (22)          (20)           (1)        (92)
Other income (expense)
 Investment earnings ...........................       --             --             1          --            --
 Interest expense ..............................         (1)            (1)           (1)         (1)           (2)
 Other .........................................       --             --             0          --            --
                                                       ----          -----         -----        ----         -----
   Total other income (expense) ................         (1)            (1)          0            (1)           (2)
Loss before income taxes .......................       (11)          (23)          (20)           (2)        (94)
Income tax benefit .............................         (5)            (9)           (7)       --            --
                                                       -----         ------        ------       ----         -----
Net loss .......................................         (6)%        (14)%         (13)%          (2)%       (94)%
                                                       ====          =====         =====        ====         =====
</TABLE>



                                       26

<PAGE>


Six Months Ended June 30, 2000 and 1999

     Revenues.  For  the  six months ended June 30, 2000, revenues increased 45%
to  $6.5  million  from $4.5 million in the corresponding period of 1999. Due to
revenue  deferrals  required  under  SOP 97-2, a significant portion of software
license  bookings  in  the  first  six  months  of  2000  will  be recognized in
subsequent periods.

     Software  sales  revenue  increased  46% to $4.9 million for the six months
ended  June 30, 2000 from $3.3 million in the corresponding period of 1999. This
increase  resulted  primarily  from  increased sales of our Vector NTI Suite and
sales  of  our  GenoMax  enterprise  system,  which was introduced in late 1998.
Increased  Vector NTI Suite sales resulted primarily from expansion of our sales
force.

     Professional  services  revenue  increased  43% to $1.7 million for the six
months  ended  June  30,  2000  from $1.2 million in the corresponding period of
1999.  This  increase  resulted  primarily  from  an  expansion  of our services
provided  to  the  NCBI  and  an  increase in the number of personnel performing
services  under  our  subcontracts.  For  the  six  months  ended June 30, 2000,
services  provided  to the NCBI under subcontracts accounted for $1.5 million or
90% of professional services revenue and 23% of consolidated revenues.

     Cost  of Revenues. For the six months ended June 30, 2000, cost of revenues
increased  27%  to $1.1 million from $0.9 million in the corresponding period of
1999.  Costs  of  software  revenues  consist  primarily  of manufacturing costs
incurred  on an as needed basis that is driven by supply level, cost of shipping
products,  and  the  cost  of  providing training and customer support. Costs of
professional  services  revenues  consist  primarily  of salaries, benefits, and
related expenses of our professional services personnel.

     Costs  of  software  license  and customer support revenue increased 59% to
$0.2  million  for  the  six months ended June 30, 2000 from $0.1 million in the
corresponding  period  of  1999. This increase resulted primarily from increased
sales of our Vector NTI Suite and sales of our GenoMax enterprise system.

     Costs  of  professional services revenues increased 20% to $0.9 million for
the  six  months  ended  June  30,  2000  from $0.7 million in the corresponding
period  of  1999.  This  increase resulted primarily from increased personnel on
the NCBI subcontracts.

     Margins  on  our  software  license  and  customer support and professional
services  revenues  improved  for  the  six-month  period  ended  June  30, 2000
compared  to the prior comparable period primarily as a result of the increasing
size  of  our  customer base and the reduction in the relative cost of producing
products  and providing services stemming from our spreading production overhead
costs across a larger customer base.

     Selling,  General  and  Administrative  Expenses.  For the six months ended
June  30,  2000,  selling, general and administrative expenses increased 216% to
$7.6  million  from  $2.4  million  in  the  corresponding  period of 1999. This
increase   primarily  reflects  salary  and  benefits  expenses  for  additional
personnel  and  related  expenses  including  increased rent and travel costs to
support  our  business  and  revenue  growth, along with costs associated with a
significant  increased marketing effort. Headcount for the period ended June 30,
2000  was  173 compared to 79 in the corresponding period of 1999. In connection
with  this  increase  in  headcount selling, general and administrative expenses
experienced a similar proportionate increase.

     Research  and Development Expenses. For the six months ended June 30, 2000,
research  and  development  expenses  increased  119%  to $2.5 million from $1.1
million  in  the corresponding period of 1999. The increase reflects expense for
an  increase in the headcount of our research and product development team as we
expand  our product development efforts. Headcount for the period ended June 30,
2000  was  173 compared to 79 in the corresponding period of 1999. In connection
with  this increase in headcount research and development expenses experienced a
similar proportionate increase.

     Stock  Based  Compensation.  For  the six months ended June 30, 2000, stock
based  compensation expenses increased 3593% to $1 million from $0.03 million in
the  corresponding period of 1999. The increase reflects compensation related to
discounted stock option grants and restricted stock awards.


                                       27
<PAGE>


     Income  Taxes. We incurred net losses for each of the six months ended June
30,  2000  and  1999.  At  present,  we  have  an accumulated net operating loss
carryforward  of  $21.4  million,  primarily  as  a  result  of  the exercise of
non-qualified  stock  options.  The  tax provision for the six months ended June
30,  1999  and  2000  was $0.01 million and $0.0 million, respectively, using an
effective  rate  of 20.3% and 0%, respectively. The provision for the six months
ended  June  30,  2000  reflects  a  valuation  allowance  recorded  against the
increase  in  net operating losses and the change in book basis versus tax basis
of deferred revenue and stock based compensation.

     Net  Loss.  We incurred a net loss of $6.1 million for the six months ended
June  30,  2000,  compared  with  a net loss of $0.08 million for the six months
ended June 30, 1999.

Years Ended December 31, 1999 and 1998


     Revenues.  For the year ended December 31, 1999, revenues increased 143% to
$10.0 million from $4.1 million for the year ended December 31, 1998.

     Software  sales revenue increased 166% to $7.3 million from $2.7 million in
the  year  ended  December  31,  1998  due  to increased sales of our Vector NTI
desktop  software  and the introduction of our GenoMax enterprise system in late
1998.

     Professional  services  revenue  increased  96%  to  $2.7 million from $1.4
million  in  the  prior  year.  In  1999,  services  provided  to the NCBI under
subcontracts  accounted  for  100%  of  professional services revenue and 27% of
consolidated revenues.

     Cost  of  Revenues.  For  the year ended December 31, 1999, overall cost of
revenues increased 59% to $2.0 million from $1.3 million in the prior year.

     Costs  of  software  license and customer support revenue increased 113% to
$0.4  million  from  $0.2  million  in  the  prior  year. This increase resulted
primarily  from  increase manufacturing, shipping costs as a result of increased
software license sales and costs of providing training and customer support.

     Costs  of professional services revenues increased 49% to $1.6 million from
$1.1  million  in  the  prior  year.  This  increase resulted primarily from the
increase in personnel on the NCBI subcontracts.


     Selling,  General  and Administrative Expenses. For the year ended December
31,  1999,  selling,  general and administrative expenses increased 183% to $7.0
million  from  $2.5  million  in the year ended December 31, 1998. This increase
primarily  reflects  our  large  investment in sales and marketing personnel and
includes  salary  and  benefits for an increase in headcount, and increased rent
and travel costs to support our revenue growth.


     Research  and  Development  Expenses. For the year ended December 31, 1999,
research  and  development  expenses  increased  123%  to $2.6 million from $1.2
million  in  the  year ended December 31, 1998. This increase reflects increases
in  the  headcount  for  our  research  and  product development team reflecting
expanded product development efforts.

     Stock  Based  Compensation.  For  the  year  ended December 31, 1999, stock
based  compensation  expenses  increased 677% to $0.1 million from $0.02 million
in  the  year  ended  December  31, 1998. The increase reflects discounted stock
option grants and restricted stock awards.


     Income  Taxes.  We incurred net losses for each of the years ended December
31,  1999  and  1998.  At December 31, 1999, we had an accumulated net operating
loss  carryforward of $1.3 million. The tax benefit for the years ended December
31,  1998  and  1999  was  $0.4 million and $0.7 million, respectively, using an
effective  rate  of 40.8% and 35.6%, respectively. The decrease in the effective
tax  rate  is  attributable  to  a  reduction  in  research  and development tax
credits,  a rate differential in the utilization of net operating losses carried
back  to  1997, and compensation expense associated with qualified stock options
in  1999,  which  is  not  deductible  for tax purposes. The increase in the tax
benefit  primarily  reflects the increase in net operating losses and the change
in  book  basis  versus  tax  basis  of  deferred  revenue, which is included in
taxable income at the date of sale but deferred for book purposes.


     Net  Loss.  We  incurred  a  net  loss  of  $1.3 million for the year ended
December  31,  1999  and  a net loss of $0.6 million for the year ended December
31, 1998.


                                       28
<PAGE>


Years Ended December 31, 1998 and 1997


     Revenues.  For  the year ended December 31, 1998, revenues increased 87% to
$4.1 million from $2.2 million in the year ended December 31, 1997.

     Software  sales revenue increased 105% to $2.7 million from $1.3 million in
the prior year due to increased sales of our Vector NTI desktop software.

     Professional  services  revenue  increased  61%  to  $1.4 million from $0.9
million  in  the prior year. In 1998, professional services provided to the NCBI
under  subcontracts  accounted for 100% of professional services revenue and 34%
of consolidated revenues.

     Cost  of  Revenues.  For  the year ended December 31, 1998, overall cost of
revenues increased 69% to $1.3 million from $0.8 million in the prior year.

     Costs  of  software  license and customer support revenue increased 399% to
$0.2  million  from  $0.04  million  in  the  prior year. This increase resulted
primarily  from  increase  manufacturing  and  shipping  costs  as  a  result of
increased software license sales.

     Costs  of professional services revenues increased 51% to $1.1 million from
$0.7  million  in  the  prior  year.  This  increase resulted primarily from the
increase in personnel on the NCBI subcontracts.


     Selling,  General  and Administrative Expenses. For the year ended December
31,  1998,  selling,  general and administrative expenses increased 130% to $2.5
million  from  $1.1  million in the prior year. This increase primarily reflects
increased  salary  and benefits for an increase in headcount, and increased rent
and travel costs to support revenue growth.


     Research  and  Development  Expenses. For the year ended December 31, 1998,
research  and  development  expenses  increased  219%  to $1.2 million from $0.4
million  in  the  year ended December 31, 1997. This increase reflects increases
in  the  headcount  for  our  research  and  product development team reflecting
expanded product development efforts.

     Stock  Based  Compensation.  For  the  year  ended December 31, 1998, stock
based  compensation expenses decreased 92% to $0.02 million from $0.2 million in
the  year  ended  December  31,  1997.  The  decrease  reflects  a  reduction of
non-qualified discounted stock option grants.


     Income  Taxes.  We  incurred net losses for each of the year ended December
31,  1998  and  1997.  At December 31, 1998, we had an accumulated net operating
loss  carryforward of $0.3 million. The tax benefit for the years ended December
31,  1997  and  1998  was  $0.1 million and $0.4 million, respectively, using an
effective  rate  of 46.9% and 40.8%, respectively. The decrease in the effective
tax  rate is attributable to a reduction in research and development tax credits
in  1998  in  comparison to 1997. The research and development tax credit is the
result  of  qualifying  expenditures  incurred in relation to the development of
our  software  products.


     Net  Loss.  We  incurred  a  net  loss  of  $0.6 million for the year ended
December  31,  1998  and  a net loss of $0.1 million for the year ended December
31, 1997.


                                       29
<PAGE>


Quarterly Results of Operations

     The  following  table sets forth unaudited quarterly consolidated financial
data  and  additional  data  for  the five quarters in the period ended June 30,
2000,  and  includes  such  data  as  a  percentage of our total revenue for the
periods  indicated. The unaudited quarterly consolidated financial data has been
prepared   on  a  basis  consistent  with  the  audited  consolidated  financial
statements,  which are included in this prospectus, and include all adjustments,
consisting  only  of normal recurring adjustments, that we consider necessary to
present  fairly  this information when read in conjunction with our consolidated
financial statements and notes thereto in this prospectus.



<TABLE>
<CAPTION>
                                                                QUARTER ENDED
                                         -----------------------------------------------------------
                                          JUNE 30,       SEPTEMBER 30,            DECEMBER 31,
                                            1999              1999                    1999
                                         ---------- ------------------------ -----------------------
                                                                 (UNAUDITED)
                                                               (IN THOUSANDS)
<S>                                      <C>        <C>        <C>           <C>        <C>
Revenues:
 Software license and customer
  support ..............................   $2,273       79%      $  1,136        59%       $2,820
 Professional services .................      618       21            779        41          799
                                           ------       --       --------        --        ------
  Total revenues .......................    2,891      100          1,915       100        3,619
Cost of revenues:
 Software license and customer
  support ..............................       76        3             71         4          187
 Professional services .................      388       13            422        22          459
                                           ------      ---       --------       ---        ------
  Total cost of revenues ...............      464       16            493        26          646
Gross profit ...........................    2,427       84          1,422        74        2,973
Operating expenses:
 Selling, general and
  administrative .......................    1,309       45          1,871        97        2,732
 Research and development ..............      644       22            637        34          831
 Stock based compensation ..............        9       --             26         1           86
 Depreciation and amortization                 48        2             78         4          105
                                           ------      ---       --------       ---        ------
  Total operating expenses .............    2,010       69          2,612       136        3,754
Income (loss) from operations ..........      417       15         (1,190)      (62)        (781)
Other income (expense):
 Investment earnings ...................        1       --             42         2           22
 Interest expense ......................      (17)        (1)         (22)         (1)       (32)
 Other .................................                --               (4)     --             (7)
                                                       -----     -----------    -----      --------
  Total other income
   (expense) ...........................      (16)        (1)          16         1          (17)
Income (loss) before income
 taxes .................................      401       14         (1,174)      (61)        (798)
Income tax provision (benefit) .........      146        5           (434)      (23)        (305)
                                           ------      -----     ----------     -----      -------
Net income (loss) ......................   $  255        9%      $   (740)      (38)%      $(493)
                                           ======      =====     ==========     =====      =======
Headcount:
 Number of Personnel
  (Cumulative) .........................       79                     104                    117

<CAPTION>
                                                                 QUARTER ENDED
                                         --------------------------------------------------------------
                                                 MARCH 31,                       JUNE 30,
                                                   2000                            2000
                                         ------------------------- ------------------------------------
                                                                  (UNAUDITED)
                                                                 (IN THOUSANDS)
<S>                                      <C>         <C>           <C>        <C>           <C>
Revenues:
 Software license and customer
  support .......................................             78%         $ 2,411              75%         $ 2,443              74%
 Professional services ..........................             22              797              25              858              26
                                                         -------          -------         -------          -------         -------
  Total revenues ................................            100            3,208             100            3,301             100
Cost of revenues:
 Software license and customer
  support .......................................              5              100               3              132               4
 Professional services ..........................             13              425              13              455              14
                                                         -------          -------         -------          -------         -------
  Total cost of revenues ........................             18              525              16              587              18
Gross profit ....................................             82            2,683              84            2,714              82
Operating expenses:
 Selling, general and
  administrative ................................             75            3,424             107            4,141             125
 Research and development .......................             23              961              30            1,510              46
 Stock based compensation .......................              2              556              17              418              13
 Depreciation and amortization ..................              3              148               5              195               6
                                                         -------          -------         -------          -------         -------
  Total operating expenses ......................            103            5,089             159            6,264             190
Income (loss) from operations ...................            (21)          (2,406)            (75)          (3,550)           (108)
Other income (expense):
 Investment earnings ............................             --                6              --                9               0
 Interest expense ...............................             (1)             (45)             (1)             (75)             (2)
 Other ..........................................             --               (5)             --               (3)              0
                                                         -------          -------         -------          -------         -------
  Total other income
   (expense) ....................................             (1)             (44)             (1)             (69)             (2)
Income (loss) before income
 taxes ..........................................            (22)          (2,450)            (76)          (3,619)           (110)
Income tax provision (benefit) ..................             (8)              --              --               --               0
                                                         -------          -------         -------          -------         -------
Net income (loss) ...............................            (14)%        $(2,450)            (76)%        $(3,619)           (110)%
                                                         =======          =======         =======          =======         =======
Headcount:
 Number of Personnel
  (Cumulative) .........................                                      147                              173

</TABLE>



     Software  license  and  customer  support  revenues reported on a quarterly
basis  from June 30, 1999 through June 30, 2000 increased substantially with the
exception  of  the quarter ended September 30, 1999. This increase resulted from
increased  sales of our Vector NTI Suite and GenoMax enterprise systems. For the
quarter  ended September 30, 1999, sales were lower due to seasonal fluctuations
of  software  procurement  and  the  deferral  of  revenue  as  a  result of the
application  of  revenue  recognition  criteria  in  accordance  with  generally
accepted accounting principles.

     Professional  services  revenue reported on a quarterly basis from June 30,
1999  through  June  30,  2000  increased  substantially.  The addition of a new
subcontract  in  the  quarter  ended  September  30,  1999  and modifications to
existing  contracts  for  the  other  reported  periods  increased the number of
personnel  performing  services  under  our subcontracts and therefore increased
the overall professional services revenue.



                                       30
<PAGE>


     Software  license  and customer support costs reported on a quarterly basis
from  June  30, 1999 through June 30, 2000 fluctuated throughout the quarters as
a  result of manufacturing costs incurred on an as needed basis driven by supply
level.

     Professional  services  costs  reported  on a quarterly basis from June 30,
1999  through  June  30,  2000  increased  in  relation  to  the addition of new
contracts  and  modification  of  our  existing contracts. For the quarter ended
March  31,  2000,  there was a decrease in the cost of professional services due
to a decrease in the number of personnel working on the contracts.

     Operating  expenses  reported  on  a  quarterly  basis  from  June 30, 1999
through  June  30, 2000 increased as we experienced substantial growth. Expenses
include   additional   personnel  and  related  salary  and  benefits  expenses,
significant  marketing  efforts  and  other  costs that support our business and
revenue growth such as travel and rent expense.

MARKETS

     Geographically,  North  America,  Europe,  and  Japan represent our largest
markets,  accounting  for  72%,  20%, and 6%, respectively, of sales through May
31,  2000,  and  79%,  17%, and 1%, respectively, of sales in 1999. All sales to
foreign-based  customers  are  invoiced  and  paid in U.S. dollars. Our customer
base  is  comprised  of  companies  in  the  pharmaceutical,  biotechnology, and
agricultural-life  science  sectors, as well as academic and government research
institutes.


LIQUIDITY AND CAPITAL RESOURCES


     From  our commencement of commercial operations in 1993 until June 1999, we
funded  our  growth primarily with internally generated cash flow. In June 1999,
we  raised  $4.0  million  in  venture  financing. At June 30, 2000, we had $2.1
million  in  cash and cash equivalents, a net decrease of $2.1 million from June
30,  1999,  an  increase of $0.7 million from December 31, 1999, and an increase
of $1.8 million from December 31, 1998.

     During  the  six  months  ended  June 30, 2000 we generated $7.4 million of
cash  from  operations  compared  to  $4.8  million for the comparable period in
1999.  For the years ended December 31, 1999 and 1998, we generated $9.0 million
and  $4.4  million  of  gross  cash from operations before consideration of cash
outflows,  respectively.  Gross cash used by operations for the six months ended
June  30,  2000  was  $11.0  million compared to $4.5 million for the comparable
period  in  1999.  Gross cash used by operations for the year ended December 31,
1999  was $11.6 million compared to $4.4 million for the year ended December 31,
1998.  The  net  increase in cash used by operations over these periods reflects
the  continued  growth of our business, particularly as related to personnel and
related infrastructure expenses.

     Net  cash  provided  by  financing  activities was $5.5 million for the six
months  ended  June  30,  2000  compared  to  net  cash  provided  by  financing
activities  of $3.9 million for the comparable period in 1999. Net cash provided
by  financing  activities  was $5.1 million for the year ended December 31, 1999
and  $0.05  million  for  the  comparable  period  in  1998. On June 22, 1999 we
entered  into  a purchase agreement with FBR Technology Venture Partners, LP for
the  sale  of  2,161,265 shares of our series A redeemable convertible preferred
stock,  $0.01  par  value.  The  shares were sold for an aggregate price of $4.0
million, or $1.85 per share.


     Net  cash  used in investing activities was $1.2 million for the six months
ended  June  30,  2000 compared to net cash used in investing activities of $0.4
million  for  the  comparable  period  in  1999.  Net  cash  used  in  investing
activities  was  $1.4  million  for  the  year ended December 31, 1999 and $0.07
million  for  comparable  period  in 1998. The cash used in investing activities
over those periods were for the purchase of furniture and equipment.


     In  May  1999,  we  entered  into a loan agreement and a security agreement
with  PNC  Bank,  National  Association,  in  connection  with the creation of a
credit  facility  consisting of a secured revolving credit line and an equipment
line  of  credit.  In  February 2000, we entered into a fourth amendment to such
loan



                                       31
<PAGE>


agreement  increasing  the  maximum  availability  under  each  of  the  secured
revolving  credit line and equipment line of credit to $3.0 million, for a total
of  $6.0  million. In connection with this amendment, we entered into an amended
and  restated  revolving  credit note and an amended and restated equipment line
of credit note.

     The  revolving  credit  note  allows  us to borrow, repay and re-borrow the
principal  thereunder  until  February 2, 2001. An amount equal to our qualified
accounts  receivable  is  available  for  borrowing  under  this  note.  Amounts
outstanding  under  the  revolving credit note accrue interest at the prime rate
as  reported in the Wall Street Journal plus one percent per annum with interest
due  and  payable  each month. The principal and any accrued but unpaid interest
are  due and payable on February 2, 2001, or such later date as may be agreed to
by PNC Bank and us.

     The  equipment line of credit note allows us to borrow the principal amount
thereunder  until  February  2, 2001. An amount equal to our qualified equipment
is  available  for  borrowing  under  this  note.  Amounts outstanding under the
equipment  line  of credit note accrue interest at the prime rate as reported in
the  Wall  Street  Journal  plus  one  and  one-quarter percent. With respect to
advances  made prior to November 6, 1999, principal and interest accrued thereon
are  payable in monthly principal amounts of $19,727 through and including April
15,  2002.  For  advances  made  after  November 6, 1999, principal and interest
accrued  thereon  shall be made in monthly principal payments of $35,607 through
and  including  October  15,  2002.  We  have  pledged  our  personal  property,
including  our  equipment,  trademarks  and  accounts receivable, to PNC Bank as
security  for  any  amounts  owed  by  us under these facilities. Under the loan
agreement,  we  are  generally restricted from incurring additional indebtedness
without  the  consent  of  PNC  Bank.  We  must  also maintain various financial
covenants,  including  minimum  cash  balance  and  certain financial ratios. In
addition,  we  may  not  declare or pay dividends or, make any distribution with
respect to any equity security during the term of the facility.

     In June 2000, we entered into a fifth  amendment to our loan agreement with
PNC Bank, in connection with a $3.0 million bridge loan for operating  expenses.
In  connection  with this  facility,  we entered into a bridge note covering any
amounts outstanding under the bridge loan. All outstanding  borrowings under the
bridge loan together with interest  accrued  thereon will become due and payable
upon the  earlier  of (1)  December  19,  2000 and (2) the  closing  date of any
initial public  offering of our capital stock or any other equity event in which
we receive an infusion of at least $3.0 million in cash or non-cash  assets from
any holder of our capital stock. Generally, in the event that we raise any funds
through  venture  financing,  private  placements of our equity  securities,  or
strategic investors, we are obligated to make a prepayment on the bridge loan up
to the maximum amount  outstanding  thereunder.  Amounts  outstanding  under the
bridge loan will accrue  interest at the prime rate plus 2.5%.  We may currently
draw up to $1.5  million and up to  $500,000,  in  increments  of  $250,000,  in
subsequent  months up to the $3.0 million maximum amount.  All borrowings  under
the bridge  loan will be secured by our pledge of  personal  property  under the
loan agreement.  To date, we have not drawn down any amounts under this facility
and the face amount remains available to us. However, as a result of our receipt
of $10 million  from our sale of Series B  preferred  stock in August  2000,  as
described below, we do not currently  anticipate  drawing down any amounts under
this facility and intend to let this  facility  expire.  In connection  with the
bridge loan we issued to PNC Bank  warrants  to purchase up to 15,030  shares of
our common stock. In the event that any amounts under the bridge loan remain due
on September 19, 2000,  we are obligated to issue an additional  warrants for an
additional  10,020 shares PNC Bank.  The warrants are  exercisable  at $5.99 per
share,  subject to adjustment for certain dilutive  issuances through June 2007.
PNC Bank was also issued certain registration rights enabling them to request to
include the common stock underlying  their warrants in a registration  statement
filed by us.

     In  June  2000,  we  issued, in the aggregate, 557,192 shares of our common
stock  in  private  sale transaction with four accredited investors and received
cash compensation totalling approximately $3.6 million.

     On  August 16, 2000, we sold 950,747 shares of our Series B preferred stock
to  Amersham  Pharmacia Biotech for aggregate proceeds of $10.0 million in cash.
We   expect  to  use  the  proceeds  for  working  capital.  These  shares  will
automatically  be  converted  into 1,587,747 shares of our common stock upon the
closing of this offering.



                                       32
<PAGE>


     We  believe  that  the net proceeds from this offering, our cash flows from
operations  and  our  existing  capital  resources  will be adequate to fund our
operations  for  the  next  24  months, although we may seek to raise additional
capital  during  that  period.  See  "Risk  Factors--We  may  require additional
funding  to  execute our business strategy. If that funding is not available, or
not  available  on terms acceptable to us, we may be required to curtail certain
marketing  and  product  development efforts" for a discussion of the investment
risks associated with the possibility of our need for additional financing.

RECENTLY ENACTED ACCOUNTING PRONOUNCEMENTS

     In  June 1998, the Financial Accounting Standards Board issued Statement of
Financial  Accounting  Standards No. 133, "Accounting for Derivative Instruments
and  Hedging  Activities, " which establishes accounting and reporting standards
for  derivative  instruments  and hedging activities. As amended by Statement of
Financial  Accounting  Standards No. 137, this standard will be effective for us
for  the years and quarters beginning after December 31, 2000, and requires that
we  recognize  all  derivatives as either assets or liabilities in the statement
of  financial  position and measure those instruments at fair value. We have not
completed  the  process  of  evaluating  the  impact  of  this statement and are
therefore  unable to predict the potential impact that implementing SFAS No. 133
will have on our financial position or results of operations.

     In  December  1999,  the  Securities  and  Exchange Commission issued Staff
Accounting  Bulletin  No.  101, Revenue Recognition in Financial Statements. The
SAB  expresses  the  SEC's  views  on  applying  generally  accepted  accounting
principles  to revenue recognition in financial statements. We do not expect the
application  of  the  SAB to have a material impact on our financial statements,
however,  certain  SEC  staff interpretations of the SAB have not been published
and  may  have  an  effect  on  the  applicability of the SAB in relation to our
consolidated financial statements.

     In  March  2000,  the  Financial  Accounting  Standards  Board  issued FASB
Interpretation  No.  44,  "Accounting  for  Certain Transactions Involving Stock
Compensation,  an  Interpretation  of APB Opinion No. 25." With the exception of
certain  provisions  that  required  earlier application, this interpretation is
effective  for  all  applicable  transactions  beginning July 1, 2000. We do not
expect  that  the adoption of this interpretation will have a material impact on
our financial statements.

QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

     Our  exposure  to  market  risk  for  changes  in  interest  rates  relates
primarily  to  the  increase or decrease in the amount of interest income we can
earn  on  our investment portfolio and on the increase or decrease in the amount
of  interest  expense  we  must pay with respect to our various outstanding debt
instruments.  Our  risk associated with fluctuating interest expense is limited,
however,  to  credit facilities that are closely tied to market rates. Under our
current  policies,  we do not use interest rate derivative instruments to manage
exposure  to interest rate changes. We ensure the safety and preservation of our
invested   principal   funds   by   limiting  default  risks,  market  risk  and
reinvestment  risk.  We  reduce  default  risk  by investing in investment grade
securities.  A  hypothetical  100  basis  point drop in interest rates along the
entire  interest  rate yield curve would not significantly affect the fair value
of  our  interest  sensitive  financial  instruments  at  December  31,  1998 or
December  31,  1999.  Declines in interest rates over time will, however, reduce
our  interest  income  and  expense  while increases in interest rates over time
will increase our interest income and expense.



                                       33
<PAGE>

                                   BUSINESS


OVERVIEW

     We  are  a  leading  global  provider  of bioinformatic software solutions.
Bioinformatics  involves  the  application  of  information  technology  to  the
analysis  of  genomic,  proteomic  and  other biomolecular data. Genomics is the
study  of an organism's genes, and proteomics is the study of proteins and their
role  in  particular diseases. Our bioinformatic software solutions are designed
to   enable  researchers  to  more  efficiently  organize,  share,  analyze  and
interpret these data that form the genetic blueprint of all organisms.

     Since  introducing  our  Vector  NTI  Suite  of  software  applications for
desktop   computers   in   1993,  we  have  sold  our  products  to  over  1,300
organizations  worldwide,  including  over 500 biotechnology, pharmaceutical and
agricultural  biotechnology  companies,  and  over  800  academic and government
research institutions. Our customers include:


       o Merck & Company,
       o Genzyme Corporation,
       o Procter & Gamble,
       o Johnson & Johnson,
       o Bristol-Myers Squibb,
       o Pfizer,
       o AstraZeneca,
       o Diversa Corporation,
       o Novartis Agribusiness Biotechnology Research,
       o the Whitehead Institute for Biomedical Research,
       o Massachusetts Institute of Technology,
       o University of Tokyo, and
       o the National Institutes of Health.

     Our  principal  software  products  are  our  Vector  NTI Suite for desktop
computers  and our more powerful and expensive GenoMax enterprise platform for a
network  of  computers  linked together for sharing data and computation. Driven
primarily  by  increased  sales  of  Vector  NTI  Suite  and the introduction of
GenoMax  in  late  1998,  our  products and complementary services generated $10
million  in  revenues  in  1999, representing a four-year compound annual growth
rate of 105%, and a 143% increase over 1998.

     Building  on  our  existing  market  penetration,  we  intend  to  grow our
business   through   increased  software  sales  and  add  new  revenue  through
professional   services,  content  channeling  and  distribution  alliances  and
e-commerce  offerings.  In  August  2000,  we entered into a long-term strategic
relationship  with Amersham Pharmacia Biotech, a subsidiary of Nycomed Amersham,
to  jointly  develop  and  market  an  expanded version of GenoMax to provide an
enterprise-wide   data   analysis   system  for  pharmaceutical  companies,  for
integrating  and  analyzing  data  from  genomics, proteomics and drug screening
production laboratories.

     As  of  August  23,  2000,  we  employed  192 people, including a sales and
marketing  team  of  51,  a  research  and product development team of 90 and an
implementation and support staff of 23.



INDUSTRY BACKGROUND


     Bioinformatics  combines  the  fields  of  molecular  biology,  information
technology,   and   Internet   communications.  Bioinformatic  software  enables
researchers,  using  automated  laboratory  research  techniques, to efficiently
organize,   share,   analyze,   and   interpret  genomic,  proteomic  and  other
biomolecular  data.  Genomic  and  proteomic factors dictate cellular functions,
susceptibility  to  disease,  and  physical  characteristics. Researchers expect
that  analysis  of  such  data  will  lead  to  new ways to diagnose, treat, and
ultimately  prevent  many  of  the  thousands  of  disorders that affect humans.
Genomic   research   involving   other  organisms,  including  plants,  animals,
bacteria,  and  viruses, could yield further advances regarding human disorders,
as  well  as  improvements  in agricultural production, industrial processes and
environmental management.


                                       34

<PAGE>

Research is Producing a Flood of Genomic and other Biomolecular Data.


     Around  the  world,  researchers  in industry, academia, and government are
producing  vast  quantities  of  biomolecular data. Much of this data is related
to:

     o DNA sequence: the  order  of  chemical subunits, called nucleotide bases,
       that make up strands of DNA found in the cells of every  living  organism
       and which encode genetic information;

     o gene  variation, function  and  expression:  the  variation  in  specific
       sequences of nucleotide  bases found on chromosomes,  called genes,  that
       control the presence of hereditary  traits;  the  biological  function of
       those  sequences;  and the  degree  to  which  a  gene's  information  is
       translated into the production of proteins within a cell; and

     o protein structure and  function:  the  sequence of chains of amino acids,
       the building  blocks of proteins,  their 3D  structures  and the means by
       which they direct the regulation, growth and repair of cells, tissues and
       organs.

     Numerous   emerging   laboratory   technologies,   including  biochips  and
microarrays,  are  automating  and  accelerating  the generation of much of this
data. The following examples indicate the rapid increase in available data:


     o On  June  26,   2000,   the   Human   Genome  Project,  an  international
       collaboration of academic and government research institutes,  and Celera
       Genomics,  each  pursuing  the  parallel  goal of  deciphering  the human
       genome,  jointly  announced  that they had  assembled  the world's  first
       working  draft  of  the  entire  human   genetic   code,   consisting  of
       approximately 3.12 billion


                                [GRAPHIC OMITTED]


     chemical nucleotide bases.

     o GenBank, a National  Institutes  of Health sponsored public repository of
       genetic  sequences of humans and over 47,000 other  organisms,  increased
       from approximately 555,000 complete sequences in 1995 to over 8.2 million
       complete  sequences as of August 2000.  GenBank's  database of nucleotide
       bases increased from  approximately 385 million bases in 1995 to over 9.5
       billion bases as of August 2000.  The parallel  chart reflects the growth
       in GenBank data through August 2000.


Bioinformatic  Software  Efficiently  Stores,  Organizes  and Integrates Growing
Volumes of Biomolecular Data.

     A  central  problem  now  facing  researchers is how to store, organize and
integrate  complex  and  rapidly  growing  data sets. Bioinformatic software can
incorporate  a  relational  database, enabling researchers to efficiently store,
organize  and  search  proteomic and genomic data according to the properties of
relevant  data  objects. Bioinformatic software can also provide a user-friendly
interface   for   efficient  access  to  numerous  in-house  and  Internet-based
databases of biomolecular information.

Bioinformatic Software Transforms Primary Data into Useful Knowledge.

     The  true  value  of the rapidly growing mass of genomic and proteomic data
lies  in  the  transformation  of  this data into advances in drug discovery and
development,   clinical   diagnostics,  agricultural  production,  environmental
management,  and industrial processes. Bioinformatic software allows researchers
to


                                       35
<PAGE>


incorporate  proprietary  and  third  party  analytical  algorithms and analysis
tools  to  interpret  and  translate  data into useful knowledge for application
across  a  variety  of  disciplines.  Bioinformatic  software  can also automate
database   queries,  analyses  and  reporting  of  research  results.  Automated
analysis  is  important because as biomolecular databases grow, researchers must
continuously update their analyses to reflect the new data.


Bioinformatic Software Facilitates Collaboration among Researchers.

     Due   to   the  volume  and  complexity  of  biomolecular  data,  efficient
collaboration  among  researchers within and across organizations is required to
accelerate   productivity.   Within   large  pharmaceutical  companies,  related
research  efforts  are  often  conducted across numerous research departments in
different  locations.  The  Human  Genome  Project,  carried out at academic and
government  research  institutes  around  the  world,  represents  an example of
inter-organizational  collaboration. Internet and intranet-enabled bioinformatic
software  solutions such as our Vector NTI Suite and GenoMax enterprise platform
serve  as  an information bridge allowing researchers to share data and results,
collaborate in analyses and better coordinate their efforts.

Bioinformatic  Software Provides an Efficient Interface for Online Data Sources.

     Currently,   researchers  can  access  over  500  public  domain  databases
containing  genomic,  proteomic  and  other biomolecular data over the Internet.
For  example,  the National Center for Biotechnology Information (NCBI) provides
access  to  GenBank  and its other databases through its Internet website, which
is  used  on  average  by  more  than  140,000 users per weekday who initiate an
average  of over 4 million queries per day. In addition, commercial providers of
genomic,  proteomic  and  other  biomolecular  data often provide customers with
access  to proprietary data through the Internet. Bioinformatic software can act
as  a  researcher's  interface  with diverse online databases. The Internet also
enables  the  distribution  of  bioinformatic software, the use of bioinformatic
software  maintained  on  remote  computers, and the online purchase of products
used in laboratory experiments.

MARKET OPPORTUNITIES IN BIOINFORMATICS


The Market for Bioinformatic Software is Large and Increasing.

     An  August  2000  independent  industry  report  by  Front  Line  Strategic
Management   Consulting   estimates   the   world-wide   bioinformatics  market,
consisting  of sales by providers of analytical software, enterprise systems and
data,  at  approximately  $468  million  in  2000, growing to approximately $2.0
billion  in  2005  and  approximately $5.4 billion in 2010. We believe that this
growth  is  being  driven  in  part  by  organizations  increasingly  turning to
external  vendors of bioinformatic software solutions, allowing them to focus on
their   core   research   competencies.   We  believe  that  market  growth  for
bioinformatic  software  solutions  is  driven  by several factors common to all
industries engaged in biological research, including:


     o the difficulty of managing and integrating the rapidly increasing volumes
       of available biomolecular data;

     o increased demand for  productivity  and  cost  efficiency  by researchers
       engaging in biological discovery;

     o the advantages of making front-end technology investments to avoid costly
       failures later in the research and development process; and

     o the  opportunity  to   claim   valuable  patent  rights  on  biomolecular
       information   underlying   diseases,    human   behavior,    agricultural
       productivity,  environmental management,  industrial processes, and other
       areas.


     We   believe  that  our  software  products  provide  researchers  with  an
efficient  means  by  which  to  access disparate data sources and give them the
tools  to  rapidly interpret, analyze and translate such data for application in
numerous disciplines. Given the market opportunities created by the



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<PAGE>


applications  of  genomic,  proteomic  and  other  biomolecular  data,  and  the
efficiency  and  productivity  gains  that  can  be  achieved through the use of
bioinformatic  software,  we  believe that the market for our software solutions
will continue to increase.

Target Markets for Bioinformatic Software Applications.

     Bioinformatic   software   facilitates   increased   research   efficiency,
productivity  and  collaboration  in  the numerous disciplines that apply a data
driven,   genomic   approach  to  biological  discovery.  In  1997,  there  were
approximately   373,500   scientists  and  engineers  engaged  in  research  and
development  in  the life sciences and related science fields, including 171,700
in  commercial  organizations  and  201,800  in academic and government research
institutions.  We  believe that the current and future markets for bioinformatic
software  products  include  all  of the industries participating in the genomic
revolution, including:

       Pharmaceutical   and   Biotechnology   Companies.   There  are  over  250
   pharmaceutical  companies  and  2,000  biotechnology  companies worldwide. In
   1999,  pharmaceutical  companies  are  estimated  to have spent approximately
   $20.1  billion  in  research  and  development in the United States alone. In
   addition,   U.S.   biotechnology   companies  are  estimated  to  have  spent
   approximately  $9.9  billion  in  research and development. Current estimates
   suggest  that  over  90%  of  potential drug candidates fail at some point in
   the  development  process  and  that  bringing  a  new  drug  to market costs
   approximately   $500   million  and  requires  an  average  of  15  years  in
   development.  In  an  effort to increase the number and quality of marketable
   drug    candidates,    pharmaceutical   and   biotechnology   companies   are
   increasingly  moving  away  from the trial-and-error approach of conventional
   laboratory  research  to  a  more effective, data-intensive, genomic approach
   to drug discovery.


       Academic  and  Government  Research Institutions. Academic and government
   research  institutions,  including  the  international institutions that make
   up   the   Human  Genome  Project,  have  been  significant  participants  in
   biomolecular  research  and  the  advancement of genomics. Public spending on
   such  research  is  expected to increase rapidly over the next several years.
   Government  funding  for  the  National  Institutes  of Health increased from
   $13.6  billion  in  1998 to $15.6 billion in 1999. The National Institutes of
   Health  budget,  over  65% of which is expected to fund grants to researchers
   and  support  internal  research  efforts, is expected to reach $17.8 billion
   in 2000, a 14% increase over 1999.


       Agricultural,   Environmental  and  Industrial  Biotechnology  Companies.
   Greater  knowledge  about  plant and animal genomes may enable researchers to
   engineer  stronger,  more  disease resistant plants and animals, resulting in
   increased  farming  and  livestock  productivity.  Researchers  may  use such
   knowledge  to  develop more nutritious and pesticide free foods and cultivate
   enzymes  that  aid  in  industrial processes and environmental management. By
   reducing   discovery   and  development  costs,  bioinformatic  software  may
   facilitate    the    creation    and   commercialization   of   agricultural,
   environmental  and  industrial products and technologies that might otherwise
   be cost prohibitive and therefore unable to gain broad market acceptance.


       Emerging   Clinical   Genomics  Industry.  Industry  participants  expect
   genomics  and  the  study  of genetic variation to play a central role in the
   market  for  clinical diagnostics and the emerging market for customized drug
   therapies.  Through  the  analysis  of  genomic data, researchers are gaining
   improved  understanding  of  disease  onset  and  progress and are working to
   translate  these  findings  into  earlier-stage  and more accurate diagnostic
   tests.  In  addition,  researchers  engaged  in the emerging pharmacogenomics
   field  are  seeking  to determine how the millions of tiny genetic variations
   among   individuals   impact  drug  response,  and  thereby  develop  a  more
   personalized approach to medicine.


OUR SOLUTION

     In  response  to  the  challenges and market opportunities presented by the
genomic  revolution,  we  develop  and  deliver  to our customers a portfolio of
proprietary bioinformatic software products and complementary services.


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<PAGE>


     Our  software  products  are  flexible  and  scalable  and  are designed to
integrate  with  one another. Our software products provide access to public and
commercial  databases  and  are designed to provide e-commerce connectivity with
vendors  of  laboratory reagents for use in actual experiments. Our products are
designed   to   be  stand-alone  applications  or  Internet-hosted  applications
provided  through  application  service  providers.  Our  current  and announced
product portfolio includes:

     o Vector NTI Suite,  a  comprehensive  desktop  analysis  and visualization
       toolset  for the  laboratory  scientist  engaged in genomic  and  protein
       sequence  research.   Vector  NTI  Suite  contains  modules  that  enable
       researchers to store,  manage,  assemble and analyze  biomolecular  data.
       Vector NTI Suite is designed to reflect and  simulate  the  workflow  and
       analytical processes used by a laboratory  researcher.  Launched in 1993,
       Vector  NTI  Suite  is  offered  for both  Microsoft  Windows  and  Apple
       Macintosh operating systems and has been licensed to over 20,000 desktops
       at over 1,300 organizations engaged in genomic research.


     o Vector Enterprise, designed  for researchers working in larger groups, or
       who collaborate with others on sequence analysis projects. Using a shared
       Oracle  relational  database,  Vector Enterprise is an enhancement to the
       Vector NTI Suite that allows  users to share data and results in a secure
       environment.  We anticipate  commercially  launching Vector Enterprise in
       the third quarter of 2000.


     o GenoMax, a large-scale  modular,  enterprise-wide data mining application
       that integrates  multiple  genomic data types and enables  researchers to
       automate   complex  analysis  tasks.   GenoMax  enables   researchers  to
       efficiently   store,   search,   manage  and  analyze  large  amounts  of
       biomolecular  data.  GenoMax  facilitates  research  collaboration and is
       designed for a coordinated  effort by a diverse team of scientists within
       or  across  organizations.  Launched  in  late  1998,  GenoMax  has  been
       purchased by 18 organizations engaged in genomic research.


     Through  the  continued  expansion and enhancement of our product offerings
to  meet  the  needs  and preferences of our customers, we seek to establish our
software   products   as  the  effective  industry  standard  for  bioinformatic
solutions.


OUR ADVANTAGES

     We  believe  that  our competitive strengths, including those listed below,
position  us  to  continue  to  be  a  global  leader  in bioinformatic software
solutions:

Superior Products and a Broad Product Portfolio


     Benefiting  from  years  of  user  feedback,  we  have tailored our product
portfolio  to  meet  the  current  and  anticipated  needs  and  preferences  of
biomolecular  researchers. Our software solutions are flexible and scalable, can
integrate  with  each  other  and  can  incorporate  proprietary and third party
analytical  algorithms  and  data  sets. Our products contain advanced analysis,
visualization  and  simulation  tools  and  reflect  the natural workflow of the
laboratory  scientist.  Our  product  portfolio  includes  Vector  NTI Suite for
individual  researchers or groups of researchers, via our Dynamic License Server
which  provides  numerous  users  concurrent  access  from a centralized server.
Vector  Enterprise  provides  a  Vector NTI Suite user group with the additional
advantages  of  a  shared  relational  database. GenoMax is a modular enterprise
platform  that  can scale to meet the needs of smaller biotechnology or academic
customers  as  well as major pharmaceutical companies and research institutions.
We   believe   that  our  broad  product  offering  and  the  sophisticated  and
user-friendly  functionality  of our products give us a competitive advantage in
the market for bioinformatic solutions.



Superior Bioinformatic Engineering Staff

     Software   engineering   for  commercial-grade  bioinformatic  applications
requires  a  high  level  of  understanding  of  software programming, molecular
biology  and market requirements. Our development teams are guided by experts in
molecular  biology  and  include  professional  software  engineers  trained  in
computer  science, statistics, mathematics, and physics. Our product development



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<PAGE>


staff  has  functional  expertise  in  C/C++,  Java, MS Windows, Apple OS, UNIX,
object-oriented  design,  system-level  programming,  relational database design
and  development  (including  Oracle),  graphical  user  interface  programming,
bioinformatics  and  molecular biology. Our product development staff has played
a  significant  role  in  developing a customized data delivery platform for the
NCBI's  GenBank,  ENTREZ  and  PubMed/MEDLINE  online  genomic  databases. As of
August  23,  2000,  we  had  90  employees  dedicated  primarily to research and
product development.


Large Existing Customer Franchise


     We  are  currently  a  leading  provider of bioinformatic software and have
attained   a   significant  level  of  industry  acceptance  for  our  products.
Introduced  in  1993,  our Vector NTI Suite is currently licensed to over 20,000
desktops   at   over   1,300   commercial,   academic  and  government  research
institutions,  including  almost all major pharmaceutical companies and over 400
biotechnology  companies.  Since its introduction in late 1998, we have sold our
GenoMax  enterprise  platform  to 18 pharmaceutical, biotechnology, and academic
customers,  including  DuPont,  Pioneer  Hi-Bred  International,  Inc.,  Genzyme
Corporation,   BASF   AG,  the  Whitehead  Institute  for  Biomedical  Research,
Massachusetts  Institute  of  Technology  and  the  University  of  Tokyo. Since
October  1994, we have provided software development services to the NCBI at the
National  Institutes  of  Health,  the leading public sector provider of primary
genomic and biomolecular data.


Vector  NTI  Suite's  Market  Penetration  which  Creates  Opportunities for New
Products and Business Lines


     Our  Vector  NTI  Suite  represents  an important strategic and competitive
advantage,  providing buyers with a lower cost means to validate the quality and
utility  of  our  software  solutions.  Moreover,  our  desktop  and  enterprise
applications  integrate with one another and allow researchers to share data and
research  results between the applications. We believe that connectivity between
desktop  and  enterprise  solutions and vendor familiarity are important factors
in  the  selection  of  an  enterprise solution. We believe that for many of our
1,300  Vector  NTI  Suite  customers,  these considerations will give GenoMax an
important  advantage  over  competing  enterprise  platforms.  At  the  time  of
purchase,  15  of  18  of our GenoMax enterprise customers were already users of
our  Vector  NTI  Suite.  We believe that we can leverage our significant Vector
NTI  Suite  customer  base  to  add  revenues  through new products and business
lines,  including  additional  professional  services,  content  channeling  and
distribution alliances, and e-commerce offerings.


Superior Sales and Marketing Capabilities


     We  have  funded  our growth primarily with internally generated cash flow.
As  a result, our sales and marketing team is focused on execution and committed
to  achieving leadership in the markets we serve. We have built an aggressive 51
person  sales  and  marketing  organization  whose  mission  is to establish our
products  as  the  standard in the bioinformatics industry. In an effort to gain
further   market   penetration   and  increase  our  brand  awareness,  we  have
co-marketed  our products with technology leaders, including Compaq, Oracle, and
Sun   Microsystems.  In  August  2000,  we  entered  into  joint  marketing  and
development   agreements  with  Amersham  Pharmacia  Biotech,  a  life  sciences
technology  company.  We  currently  maintain  a  staff of 23 representatives to
provide  software  implementation  and  integration  services  and technical and
customer  support to our existing customer base. In an effort to ensure that our
development  pipeline  satisfies  evolving market needs and preferences, leaders
from  our  product  development,  implementation  and  support,  and  sales  and
marketing teams regularly share customer feedback.


OUR STRATEGY

     Our  goal  is  to  become  the  leading  provider of bioinformatic software
solutions  and  establish  our  products  as  the  effective  industry standard.
Elements of our strategy to achieve these goals include:

Expand Our Customer Franchise Through Sales of Vector NTI Suite


     We  have  expanded  our  Vector  NTI  Suite  customer  base  to  over 1,300
organizations.  We  intend  to  expand and further penetrate our existing Vector
NTI  Suite  customer  base.  To  execute this strategy, we intend to continue to
improve our technologies and introduce advanced functionality to



                                       39
<PAGE>

Vector  NTI  Suite,  including enhanced Internet connectivity. We also intend to
broaden  our  sales  and  marketing  efforts  and  establish and expand upon our
co-marketing  and  strategic  relationships  in  order  to  expand  our  desktop
customer base.


Build  on  Vector  NTI  Suite's  Market  Penetration to Establish GenoMax as the
Leading Enterprise Platform


     We intend to leverage  the market  acceptance  of Vector NTI Suite to build
recognition and penetration of our GenoMax enterprise platform. Since its launch
in late 1998, we have sold our GenoMax enterprise system to 18 customers,  15 of
whom were  already  users of Vector NTI Suite.  We are  scheduled  to launch our
Vector Enterprise  product in the third quarter of 2000, and we expect to employ
a similar  strategy of  leveraging  the  existing  acceptance  of our Vector NTI
Suite. We also intend to continue to establish strategic industry  relationships
that  validate  the  effectiveness  and utility of GenoMax and  maximize  market
opportunities for our enterprise bioinformatic products.



Leverage Our Customer Base for New Business Lines

     We  intend  to  leverage  our  significant  customer  base  to add revenues
through  various  sources  including  new  business  lines  and  services. These
offerings include:

     Professional    Services.    We    provide    installation,    integration,
customization,  maintenance, support and user training to our GenoMax and larger
Vector  NTI  Suite customers on a fee for service basis. We believe that we will
be  able  to  increase  market penetration and customer loyalty for our software
solutions  by  increasing  the value-added professional services that we provide
to our customers.


     Channeling  and  Distribution  Alliances.  We  seek to enter into alliances
with  selected data content and technology providers and to integrate and market
their  biomolecular  data  and specialized bioinformatic hardware along with our
software  products.  To  date,  we  have  entered into four agreements to resell
third party genomic content or technology hardware.


     e-Commerce  Offerings.  Vector  NTI  Suite allows researchers to design and
simulate  laboratory  experiments  and provides researchers with recommendations
for  reagents,  enzymes and other specific genomic material necessary to execute
actual  laboratory  experiments.  We  intend  to incorporate Internet hyperlinks
into  Vector  NTI  Suite  that  will  enable  users  to purchase these materials
directly  from  partnered  vendors.  We expect to generate transaction fees from
our  partnered  vendors  for providing them access to our user base at the point
of their research decisions.


Enhance and Expand our Technology

     We  intend  to  continue  to  enhance and expand our bioinformatic software
products  and  technology  to  meet  evolving customer needs and preferences. We
intend  to aggressively attract and retain additional personnel for our research
and  product development group including skilled software engineers, information
technology  professionals  and experts in molecular biology. We are scheduled to
launch  version upgrades to our GenoMax product in 2000 that contain significant
product  enhancements  and  are  scheduled  to  commercially  launch  our Vector
Enterprise   product  in  the  third  quarter  of  2000.  We  intend  to  pursue
opportunities  to  develop  products  for  new  applications, including clinical
diagnostics and personalized drug therapy.

Establish Strategic Relationships to Maximize our Revenues

     We  intend  to enter into strategic relationships with selected partners to
expand our customer base and product distribution channels, including:


     o Co-Marketing Relationships. We intend to continue to establish and expand
       our co-marketing  relationships with leading  organizations in our target
       markets. We believe that these relationships will significantly  increase
       global market awareness of and receptivity to our software  products.  We
       have  established  co-marketing  relationships  with  technology  leaders
       including  Compaq,  Oracle,  and Sun  Microsystems.  In August  2000,  we
       entered into joint  marketing and  development  agreements  with Amersham
       Pharmacia Biotech, a life sciences technology company.



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<PAGE>

     o Internet-hosted Software Delivery  Alliances.  We  intend  to provide our
       customers with access to our software  products  through  Internet-hosted
       services. We expect that by providing our software through an application
       service provider's  Internet-based network, we will be able to accelerate
       the deployment  and facilitate the management of our software  solutions.
       In January 2000, we entered into an agreement with an application service
       provider  and  we   anticipate   offering   our   products   through  its
       Internet-based hosting network beginning in the third quarter of 2000.

Engage in Acquisitions and Strategic Investments

     Where  appropriate,  we will pursue acquisitions and strategic investments,
both  domestically  and internationally, to enter new markets and accelerate the
development  of comprehensive solutions to our customers' needs. We believe that
through   acquisitions  and  strategic  investments,  we  may  be  able  to  add
complementary  technologies,  products  and  services,  and  expand our customer
base.

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<PAGE>

OUR PRODUCT AND SERVICE LINES

<TABLE>


------------------------------------------------------------------------------------------------------------------------------------
                               SOFTWARE PRODUCTS
------------------------------------------------------------------------------------------------------------------------------------
<S>                <C>                                      <C>
 VECTOR NTI SUITE: suite of desktop applications designed for individual scientists engaged in genomic and proteomic
                   research
------------------------------------------------------------------------------------------------------------------------------------
 VERSION                  MODULES                           FUNCTIONS
------------------------------------------------------------------------------------------------------------------------------------
 VECTOR NTI SUITE 6.0     VECTOR NTI                        data analysis and visualization
 (released Q2 2000)       BIOPLOT                           sequence analysis
                          ALIGNX                            multiple sequence alignments
                          CONTIGEXPRESS                     sequence fragment assembly
                          3D MOL                            structure analysis and visualization
------------------------------------------------------------------------------------------------------------------------------------
 VECTOR ENTERPRISE (scheduled Q3 2000):            incorporates a shared relational database into a network of Vector NTI
                                                   Suite applications to enable real-time collaboration among multiple
                                                   researchers in a secure environment
------------------------------------------------------------------------------------------------------------------------------------
 GENOMAX ENTERPRISE: large-scale, modular, enterprise-wide data mining and analysis application
------------------------------------------------------------------------------------------------------------------------------------
 VERSIONS                  MODULES                          FUNCTIONS
------------------------------------------------------------------------------------------------------------------------------------
 GENOMAX 2.5               SEQUENCE ANALYSIS                similarity searches, sequence alignments and
 (released Q1 2000)                                         annotation

 GENOMAX 3.0               GENE EXPRESSION ANALYSIS         management and visualization of microarray data
                           PROTEIN 3-D STRUCTURE            analysis and prediction of protein molecular structure

 FUTURE GENOMAX VERSIONS   GENOME VIEWING                   chromosome and expressed sequence tag (EST) mapping
                           PROTEIN-PROTEIN INTERACTION      analysis of protein intracellular behavior
                           SNP ANALYSIS                     genetic variation analysis
------------------------------------------------------------------------------------------------------------------------------------
                                                        PROFESSIONAL SERVICES
------------------------------------------------------------------------------------------------------------------------------------

------------------------------------------------------------------------------------------------------------------------------------
SOFTWARE DEVELOPMENT                 Consulting and software development services provided under contract

 IMPLEMENTATION AND                  Software installation, integration and customization for GenoMax customers
 SUPPORT SERVICES
------------------------------------------------------------------------------------------------------------------------------------
                                                    CHANNELING AND DISTRIBUTION ALLIANCES
------------------------------------------------------------------------------------------------------------------------------------
 CONTENT CHANNELING AND              Partnerships to integrate and distribute third party data content and to distribute
 HARDWARE RESELLING                  specialized bioinformatic hardware with our software

 E-COMMERCE PARTNERING               Partnerships to enable Vector NTI Suite customers to use hyperlinks to make
                                     online purchases of laboratory reagents, including those specified by Vector NTI
                                     Suite's decision support functions
------------------------------------------------------------------------------------------------------------------------------------

</TABLE>

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<PAGE>

Software Products

     Our  portfolio of software products currently includes our Vector NTI Suite
desktop  application,  our  Vector Enterprise product and our GenoMax enterprise
platform.


 Vector NTI Suite

     Vector  NTI Suite is a comprehensive, integrated analysis and visualization
software  toolset  for  scientists  working  with genomic and proteomic data. We
launched  our  first  desktop  application in 1993 and released Vector NTI Suite
6.0,  our  sixth  generation  desktop  product,  in  June 2000. Vector NTI Suite
consists of five modules, each of which is described below:


     o Vector NTI. Vector NTI provides the desktop researcher with bioinformatic
       tools  to  create,   analyze,  map,  manage,  and  graphically  represent
       biological data. Vector NTI incorporates an object-oriented  database for
       the  storage  and  organization  of DNA and  protein  sequence  data  and
       biomolecular  materials  used in the cloning of disparate  DNA  molecules
       called recombinant  cloning.  These recombinant cloning materials include
       vectors,  plasmids,   oligonucleotides,   gel  markers,  and  restriction
       enzymes,  which can be organized and stored.  The database can be sorted,
       customized,  and searched  according to the  properties  of relevant data
       objects.  Vector  NTI has the  ability  to design  recombinants  based on
       built-in  biological   knowledge  and  selected  user  preferences  which
       accelerates the complex and  time-consuming  process of designing cloning
       experiments.  By developing  cloning  strategies before performing actual
       laboratory work, users save valuable research time, reduce reagent costs,
       and enhance the prospects for a successful  cloning  experiment.  Through
       its simulation  function,  Vector NTI recommends  necessary protocols and
       reagents  to  complete  the  experiment.  Vector NTI  includes  tools for
       cutting  DNA  sequences  known as  restriction  enzyme  analysis  and for
       amplifying  a DNA  sequence  called  PCR primer  design.  Vector NTI also
       enables  the  study  and  induction  of  mutations  known as  mutagenesis
       analysis and the  separation  of DNA  fragments  and proteins  called gel
       electrophoresis.   Through  Vector  NTI's  sophisticated  graphical  user
       interface, researchers can visualize their data and results of analysis.


     o BioPlot. BioPlot is  a  protein  and  nucleic acid sequence analysis tool
       that plots more than fifty  different  pre-defined  physical and chemical
       protein  analysis  types and  links  them with  feature  maps and  actual
       sequences. Amino acid scaling allows visualization of the distribution of
       the structural  and chemical  properties of amino acids along a molecular
       chain, providing clues as to the functional properties of protein regions
       or domains. These functional properties allow researchers to more quickly
       identify and understand regions of interest in molecules under study.

     o AlignX. AlignX allows  researchers  to  create and edit multiple sequence
       alignments  of  proteins  or  nucleotides.  The  multi-pane  view  allows
       relevant  domains in  individual  sequences to be linked,  localized  and
       compared  in their  alignment  and in plots of  similarity  and  sequence
       complexity,  referred to as homology.  AlignX  integrates  actively  with
       Vector NTI and can read a multitude of data formats,  a capability common
       to every module in the Vector NTI Suite.


     o ContigExpress. ContigExpress allows  the  user  to  take  small  analyzed
       sequence   fragments,   either  in  text   format   or  from   sequencing
       chromatograms,  the  output  from  automated  sequencing  equipment,  and
       visually  assemble  them  together  into a longer,  contiguous  sequence.
       ContigExpress  further  allows the user to edit the  fragments  directly,
       with the  chromatograms  in full view,  while it tracks  all the  changes
       made. The ability to  simultaneously  show sequence and trace data allows
       the  researcher  to inspect  the  relative  intensity  of the  sequencing
       chromatogram and modify the called base, if needed.

     o 3D MOL. Released  as  part  of  Vector  NTI  Suite 6.0, this tool enables
       researchers to analyze and visualize  molecule  structures using numerous
       display modes. 3D MOL enables  researchers to manipulate the 3D structure
       of protein and DNA  sequences  correlated to their  constituent  to amino
       acids and nucleotide sequences.  The analytical features of 3D MOL enable
       researchers to measure distances and angles within molecules.



                                       43
<PAGE>

  Benefits of Vector NTI Suite


     The benefits of our Vector NTI Suite include:

     o Integrated Software Suite.  Vector  NTI Suite includes a fully searchable
       database  template  that  allows  researchers  to store  and  manage  DNA
       sequences,  protein  molecules,  enzymes,  and other  biomolecular  data.
       Vector NTI Suite  allows  users to  perform  analyses  involving  several
       integrated  applications  and to store and move data objects  between the
       components   of  the   desktop   suite   without   reformatting   between
       applications.

     o Open Architecture. Vector  NTI  Suite  is  offered  for  both Windows and
       Macintosh  operating  systems and can  accommodate  data in numerous text
       formats  used in the  research  world  including  FASTA,  GenBank,  EMBL,
       SWISS-PROT,  GenPept and ASCII. The software can run from a single static
       license  for one  machine or with our  Dynamic  License  Server  that can
       allocate  a  pre-defined  number  of  users  running  the  software  on a
       centralized server. The Dynamic License Server creates an easily scalable
       environment, where the number of concurrent licenses can be set according
       to the expected usage.

     o Research Logic System  Reflects  Scientists' Natural Workflow. Vector NTI
       Suite  eliminates  many  of  the  time-consuming  laboratory  design  and
       execution  processes by generating  protocols and suggestions for cloning
       strategies,  PCR primers and DNA fragment  assembly  called oligo design,
       restriction fragment analysis,  mutagenesis analysis, protein and DNA/RNA
       analyses, multiple sequence alignments, and contig assembly.  Researchers
       are also  able to use the  graphical  features  of  Vector  NTI  Suite to
       produce  presentation  quality materials  describing the results of their
       research.

     o Internet Connectivity. Vector  NTI Suite provides connectivity to over 20
       Internet sites for searching and importing fully annotated molecules back
       into Vector NTI Suite for further  manipulation and analysis.  Vector NTI
       Suite can  analyze  these data along with data  collected  from  internal
       research as well as data from other publicly  available  sources.  Vector
       NTI Suite 6.0  incorporates  enhanced  Internet  connectivity,  providing
       users with e-commerce capability directly through our software. We intend
       to enter into  partnering  arrangements  by which this feature will allow
       users to purchase through the Internet  reagents  suggested by Vector NTI
       Suite  and  other  biomolecular  material  necessary  to  conduct  actual
       laboratory experiments.

     o Transparent Data Searching.  Vector  NTI  Suite 6.0 allows researchers to
       conduct BLAST homology  searches and query the ENTREZ and  PubMed/MEDLINE
       databases  at the NCBI through the desktop  application  without the need
       for a web browser.  BLAST is the NCBI's basic local alignment search tool
       and  involves  the use of an  algorithm  to search  online  databases  to
       compare  any  newly   discovered  DNA  or  protein  sequence  with  known
       sequences. The results of this algorithm, which allows the identification
       of regions of similarity between sequence data, can be stored and managed
       by Vector NTI Suite. The ENTREZ and  PubMed/MEDLINE  search system allows
       researchers to search the NCBI databases of biomolecular data and perform
       scientific  literature  searches.  Results of such searches can be stored
       and managed by Vector NTI Suite for later use or presentation.

     o Application Facilitates Research  Collaboration.  Vector NTI Suite allows
       researchers  to share and exchange  data and research  results from their
       individual  databases between several  installations of Vector NTI Suite.
       In addition, Vector NTI Suite supports special document types that can be
       used  as  "packagers"  for  heterogeneous   data  and  research  results.
       Geographically  distributed  users may exchange  these  documents and use
       Vector NTI Suite's  graphical  viewers to visualize each others' research
       results.

 Vector Enterprise

     Our  Vector Enterprise database software is designed for biologists working
in  larger  research  groups,  or  those  who  need to work collaboratively with
others  on  sequence  analysis  projects. Vector Enterprise is an enhancement to
the  basic Vector NTI Suite and relies on a shared Oracle relational database to
store  user  data and results. This product is coupled with the desktop database
already



                                       44
<PAGE>

present  in  the Vector NTI Suite and permits multi-user access and data sharing
across  entire  companies  or  organizations by all researchers using Vector NTI
Suite,  with  secure data storage and analysis. We are scheduled to commercially
launch the first version of Vector Enterprise in the third quarter of 2000.


 GenoMax Enterprise Solutions


     GenoMax  is  a  large-scale,  enterprise-wide, data-mining application that
enables  research  organizations  to  store, manage, integrate and analyze large
amounts   of   genomic  and  proteomic  data  from  disparate  sources.  GenoMax
incorporates  proprietary  and third party analytical tools that perform complex
integrated  analyses  across  multiple experiment types that are not possible on
desktop  programs.  GenoMax  relies  upon our user-friendly, Java-based Research
Logic  interface system and maintains an open architecture that allows new tools
and  proprietary  algorithms  to be incorporated into the GenoMax framework. The
GenoMax  architecture  supports access to the system through Intranet, wide area
network  or  dedicated Internet connectivity, while preserving data security and
integrity.  GenoMax  enables  multiple  users  to  collaborate in the design and
execution  of  research ranging from molecule analysis and annotation to complex
bioinformatic  algorithms.  The  combination  of a collaborative environment and
sophisticated   data-mining   and   management  capabilities  makes  GenoMax  an
effective tool for coordinated genomics research.


     GenoMax  was originally launched under the brand name Software Solution for
Bio-Medicine  in September 1998. Our current GenoMax 2.5 version was launched in
March  2000  and  includes  a  gene  sequence analysis module with functionality
including  database  similarity searches, multiple sequence alignments, sequence
annotation  and  visualization,  and  restriction  enzyme analysis. GenoMax 3.0,
which  is  scheduled  for  release  in  the  third  quarter  of  2000,  includes
enhancements  such  as fully distributed computing for analyses, data management
and  storage  in  order  to  achieve improved scalability and to fully utilize a
client's existing computing infrastructure.


  GenoMax Enterprise Solutions Modules

     The  following  modules  are  currently  in  development and expected to be
included in future versions of our GenoMax enterprise solution:


     o Sequence Analysis: for  database  similarity searches including BLAST and
       FASTA,   multiple   sequence   alignments,    sequence   annotation   and
       visualization,  restriction enzyme analysis,  automated search agents and
       proprietary sequence comparison tools. This module is currently available
       with GenoMax 2.5 and is scheduled to be enhanced as part of GenoMax 3.0.


     o Gene Expression Analysis:  for  management, analysis and visualization of
       microarray  data. This module is scheduled for release as part of GenoMax
       3.0.

     o Protein 3D Structure:  for prediction and analysis of tertiary structures
       of proteins including molecular  structure.  This module is scheduled for
       release as part of GenoMax 3.0.

     o Genome Viewing: for  visualization  and  analysis  of chromosome maps and
       mapping  of  expressed  sequence  tag (EST)  clusters,  transcripts,  and
       genomic sequences. This module is currently in development.

     o Protein-Protein   Interactions:   for  analysis  of protein intracellular
       behavior. This module is currently in development.


     o Single Nucleotide Polymorphism (SNP) Analysis: designed to manage rapidly
       growing volumes of data on these tiny genetic variations,  this module is
       a key  analysis  tool for  research in  pharmacogenomics.  This module is
       currently in development.



  Benefits of GenoMax


     The benefits of our GenoMax enterprise solution include:


                                       45
<PAGE>

     o Collaboration-Oriented Architecture. GenoMax  is a client-server software
       solution  that  allows  collaboration  within and  across  organizations.
       Multiple users may simultaneously  search and analyze large quantities of
       data and share their results. Computationally intensive algorithms run on
       the server  side,  while the  results  are  delivered  on the client side
       through  an  intuitive  Java-based  graphical  user  interface,  enabling
       real-time  feedback with the central server,  other users, and with third
       parties.  GenoMax secures research  analyses behind a corporate  firewall
       and  incorporates a flexible  hierarchy of user rights,  giving  managers
       control of research  projects and permitting  administrators to customize
       their  security  needs  by  adding  and  deleting   authorized  users  as
       necessary.



     o Large-Scale  Data Processing  /  High  Throughput  Research.  GenoMax  is
       designed to accommodate the needs of research  institutions  that analyze
       large amounts of genomic,  proteomic and biomolecular  data from multiple
       sources.  The Oracle  relational  database system that is integrated into
       GenoMax  automatically  updates  databases  from public and  subscription
       sources and includes alert mechanisms that notify users when new data has
       been imported.  Data can be accessed and analyzed by researchers manually
       or automatically  through GenoMax's High Throughput Research system which
       allows researchers to create  sophisticated  analysis protocols and apply
       them to process data on a 24-hour basis.


     o Flexible  Bioinformatic Framework.  GenoMax  supports  a  wide  range  of
       data-mining  algorithms,  including BLAST,  FASTA,  HMM, flexible pattern
       search, ORF analysis, and homology blocks search.  GenoMax's architecture
       is open, scalable,  secure, and easily extended so that our customers may
       incorporate   client-developed  and  publicly  available  algorithms  and
       solutions. To enhance efficiency,  GenoMax includes data management tools
       for  organized  storage and  analysis  and employs  results  filtering to
       select the most useful results according to user specifications.



Professional Services


     Software  Development.  As  part of our growth strategy, we have developed,
and  intend  to  expand,  our partnerships with genomic content providers. These
relationships  provide  us  with  additional revenue opportunities, and broaden,
validate,  and  reinforce  our bioinformatic capabilities and brand recognition.
Since  October 1994, we have provided software development services to the NCBI,
a  division  of  the  National Library of Medicine at the National Institutes of
Health.  NCBI  maintains  the  world's  largest  databases  of genomic and other
biomolecular  data,  which  are  available  via the Internet to all participants
engaged  in  genetic  and biological research. We have played a significant role
in  the  development  of  the  public content delivery interfaces for the NCBI's
databases,  including GenBank, ENTREZ, and PubMed/MEDLINE. Our relationship with
NCBI  allows  us  to  work  with  the  world's  largest genomic and biomolecular
databases,  covering  diverse  sets  of  information.  NCBI  contracts for these
services  through  intermediaries  for  whom  InforMax is a subcontractor. These
government contracts may be terminated on the behalf of the NCBI at any time.



     Implementation   and  Support  Services.  Our  implementation  and  support
services   group   provides   installation,   integration,   customization,  and
maintenance  support to our customers. We provide professional services on a fee
for  service  basis  for  our GenoMax and larger Vector NTI Suite customers. Our
implementation   and   support   group  includes  professionals  experienced  in
implementing  our  software  in conjunction with systems manufactured by leading
technology  companies including Compaq, Oracle, and Sun Microsystems. We respond
to  requests  for  customer support through numerous channels. Our service group
also  provides  training  and  educational  programs  to  researchers  using our
products.



Channeling and Distribution Alliances.



     Content  Channeling  Relationships.  We  have  entered  into  and intend to
continue  to seek distribution or reselling agreements with various biomolecular
data  content  providers to sell subscriptions to their data sets to our GenoMax
and  Vector  NTI  Suite  customers. These alliances leverage our market presence
and  use  our  software as an integration and analysis tool for the data content
of our partners.



                                       46
<PAGE>


Through  such  arrangements,  we  seek  to share in ongoing subscription content
revenues  and  receive  a  portion of milestone payments and royalties resulting
from  end-user  discoveries  derived from this content. To date, we have entered
into alliances with the following organizations:


     o AxCell Biosciences Corporation.  In  August  1999,  we  entered  into  an
       agreement with AxCell  Biosciences,  a wholly owned subsidiary of Cytogen
       Corporation,  to market AxCell's proprietary  protein-protein interaction
       database with our GenoMax enterprise  product.  AxCell is a leader in the
       production of protein-protein  interaction data. Under this agreement, we
       will develop and market, on a subscription  basis, a product that couples
       AxCell's  proprietary  protein  databases  with  our  GenoMax  enterprise
       platform. Under this agreement, we will receive a portion of subscription
       revenues,   and  milestone   payments  and  royalties   associated   with
       discoveries based on data delivered via our content platform.


     o Centre National de  la  Recherche  Scientifique (CNRS). In March 2000, we
       entered into a letter of intent with CNRS, the French National Center for
       Scientific  Research,   to  market  CNRS's  databases  with  our  GenoMax
       enterprise product.  CNRS maintains proprietary databases containing data
       on gene structure, expression, and location within the human genome. This
       product  would  be  marketed  on a  subscription  basis  and we  would be
       entitled  to  receive  a portion  of the net  revenue  from  sales to our
       customers  and a portion of any  milestone  payments and  royalties.  The
       letter of intent also  provides  for us to work with CNRS to  establish a
       European Center of Excellence in Computational Genomics and Proteomics to
       be located in Villejuif, France.


     o Structural Bioinformatics. In  August  2000, we entered into an agreement
       with   Structural    Bioinformatics,    to   market   their   proprietary
       three-dimensional  protein structure database with our GenoMax enterprise
       product.  Structural  Bioinformatics  is a leader  in the  production  of
       three-dimensional  protein structure data. Under this agreement,  we will
       develop and market,  on a  subscription  basis,  a product  that  couples
       Structural Bioinformatics'  three-dimensional protein structure databases
       with our GenoMax enterprise platform.  As resellers of this data, we will
       receive a portion of subscription revenues.


     Hardware  Reselling  Alliance.  We believe that we can further leverage our
market  presence and increase our product offerings to our customers by entering
into  distribution and reselling agreements with selected bioinformatic hardware
companies.   In   March  2000,  we  entered  into  an  alliance  with  TimeLogic
Corporation  to  link  its  DeCypher  genomic analysis accelerator products that
speed  data  mining,  with  our  GenoMax  enterprise  platform. Pursuant to this
agreement,  we  will  market  DeCypher  to  our customers along with our GenoMax
product and share in a portion of net revenues and maintenance fees.


     e-Commerce  Opportunities.  Researchers  use our Vector NTI Suite to design
and  simulate laboratory experiments. Vector NTI Suite provides researchers with
specific  experimental  protocols and recommendations for reagents, enzymes, and
other   specific   genomic  material  necessary  to  execute  actual  laboratory
experiments.  To  extend  this  functionality, we intend to incorporate Internet
hyperlinks  into  our  Vector  NTI  Suite  product  to  enable users to purchase
genomic  products and materials relevant to their research directly from online,
partnered   reagent  vendors.  We  expect  to  generate  transaction  fees  from
partnered  vendors  for  providing  them access to our user base at the point of
their research decisions.



CUSTOMERS



     We  license our desktop software solutions to pharmaceutical, biotechnology
and  agricultural  biotechnology  companies,  academic  and  government research
institutions,   and  individual  researchers.  Vector  NTI  Suite  is  currently
licensed to over 20,000 desktops at 1,300 organizations, including over



                                       47
<PAGE>


500  pharmaceutical,  biotechnology and agricultural biotechnology companies and
800  academic and government research institutions. Introduced in late 1998, our
GenoMax  enterprise  platform  has  been  purchased  by  18 customers. Our major
customers include:



<TABLE>
<S>                                <C>                                                 <C>
Pharmaceutical and Agricultural Biotechnology Companies
o AstraZeneca UK Limited           o E.I. du Pont de Nemours and Company               o Pioneer Hi-Bred International, Inc.
o Aventis Pharmaceuticals, Inc.    o Hoechst Marion Roussel                            o Procter & Gamble
o BASF AG                          o Johnson & Johnson                                 o Eli Lilly and Company
o Bristol-Myers Squibb Company     o Merck & Company, Inc.                             o Novartis Agribusiness
                                   o Pfizer, Inc.                                        Biotechnology Research, Inc.
Biotechnology Companies
o Amgen Inc.                       o Biofrontera Pharmaceuticals GmbH                  o Genzyme Corporation
o Aurora Biosciences Corporation   o Diversa Corporation                               o Microbia Incorporated

Academic and Government Research Institutions
o Katholieke Universiteit Leuven   o National Institutes of Health                     o University of Pennsylvania
o European Molecular Biology       o The Whitehead Institute for Biomedical Research   o Washington University in St. Louis
  Laboratory (EMBL)                o Massachusetts Institute of Technology             o University of Tokyo
</TABLE>


MARKETING AND SALES


     Our  marketing and sales force consists of 51 employees. Our marketing team
uses  a variety of strategies to increase brand recognition for our products and
reach  a  broader  base  of  potential  customers for our bioinformatic software
solutions.  In  addition, the efforts of our service and implementation group to
educate,  convert,  and train researchers on our enterprise and desktop products
support our marketing efforts.

     Our  sales  force is divided into territorial revenue teams. Each territory
is  headed  by  an experienced regional sales vice president and includes a team
dedicated   to   direct  sales  efforts  for  our  GenoMax  enterprise  software
solutions.  GenoMax  enterprise  sales  involve  a significantly longer and more
complex  sales  cycle than our desktop applications, often involving many levels
of procurement and purchasing decisions by a customer organization.

     Each  territorial  revenue  team also includes a tele-sales team focused on
sales  of  our  Vector  NTI Suite of desktop applications. Historical experience
shows  the  typical  sales  cycle  to  be  30  to  60 days from an indication of
interest  to  a  purchase  order.  In  addition,  Vector NTI Suite consists of a
number  of  component  modules,  which allows us to market to new users at a low
initial  price  and  sell  additional  modules  later.  We  also  offer flexible
licensing  alternatives  that  allow  us  to  price consistently across customer
organizations of different sizes.



CO-MARKETING ALLIANCES


     In  connection  with  our sales and marketing efforts, we seek to establish
strategic   alliances   and  co-marketing  relationships  to  accelerate  market
penetration  of  our  bioinformatic  software.  We  believe  that  purchasers of
bioinformatic  software  often look to market leaders in technology to keep them
abreast  of possible emerging industry standards. We also believe that customers
often  select technology leaders because of a perception that there is a reduced
risk  in  making a technology commitment. We have established relationships with
the following leaders in the technology industry:


     o Compaq. We jointly  market  our  software products with Compaq technology
       and benefit from a financing  arrangement in which Compaq leases computer
       hardware  that is coupled  together  with our software to its  customers.
       This turnkey approach  reduces  financial  barriers,  and streamlines the
       installation of our enterprise  software solutions by pre-loading it onto
       Compaq servers.  Compaq also has agreed to feature our GenoMax enterprise
       software  in its  Center for  Excellence  in  Bioinformatics,  one of its
       technology demonstration sites targeted to the biotechnology industry. In
       June 2000, we jointly conducted a nine-city seminar series with Compaq on
       enhanced biological data mining and integrated genomic analysis.


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<PAGE>

     o Oracle. We jointly market our software products with Oracle databases and
       cooperate in the re-selling of Oracle  database  technology.  We are also
       working with Oracle to  streamline  the  installation  of our  enterprise
       software   solutions  and  maximize  the  functionality  and  cooperative
       features of our technologies.

     o Sun Microsystems. We  jointly  market our software products in connection
       with the sale of Sun Microsystems servers to industry  participants.  Sun
       also has agreed to install our GenoMax enterprise  platform in one of its
       key technology demonstration sites.

     Web-based  Provision  of  Bioinformatic  Software  Applications. In January
2000,  we  entered  into  an  alliance  with  an  application  service  provider
specializing   in   Internet-hosted   research  informatics  solutions  for  the
biopharmaceutical  market,  to  offer  our GenoMax and Vector NTI Suite software
solutions  as  Web-based,  hosted  applications. We expect that by providing our
software  through an application service provider, we will be able to accelerate
the  deployment  and  facilitate  the  management  of our software solutions. We
intend  to  begin  providing  our  bioinformatic software solutions through this
Internet-hosted method in late 2000.



STRATEGIC COLLABORATION WITH AMERSHAM PHARMACIA BIOTECH

     In  August  2000,  we  entered  into  a 20-year strategic relationship with
Amersham  Pharmacia  Biotech  under  which we will jointly develop and market an
expanded  version  of GenoMax to provide an enterprise-wide data analysis system
for  pharmaceutical  companies for integrating and analyzing data from genomics,
proteonics  and  drug  screening  production  laboratories. Under the agreements
outlining  our relationship, we will receive a portion of the revenues resulting
from  the  sale,  license or maintenance fees associated with such products. The
agreements  can  be  terminated prior to the end of the term based upon a breach
by  the  other  party  and are subject to certain testing and acceptance periods
for   the   products  jointly  developed.  In  connection  with  this  strategic
relationship,  Amersham  purchased  950,747  shares  of  our  Series B preferred
stock,  which  are  convertible  into  1,587,747  shares  of  common  stock, for
aggregate proceeds to us of $10 million in cash.



RESEARCH AND DEVELOPMENT


     Recruiting  and  retaining  skilled  personnel for our research and product
development  group is a critical component of our current and future competitive
success.  As  of  August  23,  2000,  we had 90 employees dedicated primarily to
research  and product development. Our research and development team consists of
applications    and    systems   programmers,   database   administrators,   and
bioinformatics  designers,  numerous  of  which have experience in both computer
science  and molecular biology. To date, we have not encountered any significant
turnover  in our research and product development group, and we believe that our
products  and  services  have  benefited  from  this  level  of  continuity. Our
research  and  development  expenditures  in  1997,  1998,  and  1999  were $0.4
million,  $1.2  million,  and $2.6 million, respectively, and approximately $2.5
million for the first six months of 2000.

     Our  research  and product development group possesses core competencies in
C/C++,  Java,  MS  Windows, Apple OS, UNIX, object-oriented design, system-level
programming,  relational  database  design  and  development,  including Oracle,
graphical  user  interface  programming,  bioinformatics, and molecular biology.
Our  team  has  a  significant level of aptitude in working with a wide array of
biomolecular  data,  including  DNA  and  protein sequences and structures, gene
expression,  genetic maps, protein-protein interaction, and SNPs. We continue to
enhance  our  existing  products  in an effort to expand their functionality and
utility.  Our  research  and  product  development  team  seeks  to  develop new
products  that  use  computational  methods  to  further  understand  biological
processes   and   enable  users  of  genomic  data  to  realize  efficiency  and
productivity gains.



COMPETITION

     We   believe  that  the  principal  competitive  factors  in  the  evolving
bioinformatic software industry include:

     o functionality and ease of use of software products;

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<PAGE>

     o rapid incorporation of technological and biomolecular innovations;

     o product flexibility, scalability, and integration;

     o level   of   customer   service,   product  implementation,  and  support
       functions;

     o existing market penetration and brand awareness;

     o alliances with strategic partners and technology market leaders; and

     o price.


     We  face,  or  expect  to  face,  competition  for  market  leadership from
industry participants, including:

     o third party commercial software vendors;

     o bioinformatic developers;

     o internal   bioinformatics  departments  of  some  of  our  customers  and
       potential customers;

     o organizations    engaging    in   the   provision   of   Internet-hosted,
       bioinformatic software; and

     o companies  facilitating Internet-based e-commerce between participants in
       our industry.


     We  believe  that  we  compete  most often with LION bioscience, NetGenics,
Compugen,  Genomica,  DNA  Star,  Rosetta  Inpharmatics,  DoubleTwist and GCG, a
division  of  Oxford  molecular being sold to Pharmacopeia. We intend to compete
with   such   organizations   regarding   pricing  and  products  and  services,
functionality  of  products,  quality  of  service, strength of organization and
support and training.


     We  believe  that  in response to existing and future market opportunities,
there  is  a  strong  likelihood  of additional market participants. Many of our
current  and  potential  competitors  have  longer operating histories, stronger
name  recognition, and significantly greater financial, technical, and marketing
resources  than we do. As a result of these advantages, these competitors may be
better  able  to adopt more aggressive pricing policies and better positioned to
respond to changes in customer preference or technology.



INTELLECTUAL PROPERTY



     We  believe  that  the proprietary protection of our bioinformatic software
products  is  critical to the success of our business and our ability to compete
effectively.  We  rely upon a combination of trade secret, patent, copyright and
trademark   laws,   license  agreements,  nondisclosure  and  other  contractual
provisions  to  protect  our proprietary rights in our products, technology, and
processes.  In  January  2000,  Dr. Vadim Babenko, our Chief Technology Officer,
assigned  to us an application for a United States patent directed to InforMax's
approach   to  integrated  access  to  biomedical  resources.  Dr.  Babenko  has
previously  assigned  to  us  two copyrights relating to our Vector NTI Suite of
desktop  applications. To date, we have been issued U.S. trademark registrations
for  the  marks  InforMax & Double Helix Design, Vector NTI, AlignX and BioPlot.
We  have  filed  trademark  applications  in  the  U.S.  for  the marks GenoMax,
InforMax,  the  InforMax  Double  Helix  Logo Design, HTR, HTR Partners Program,
SSBM,   ContigExpress,  High-Throughput  Research,  and  Software  Solution  for
Bio-Medicine,  among  others.  In addition, we have filed trademark applications
in  the  European  Community  Trademark  Office  ("CTM")  for  the marks AlignX,
BioPlot,  Vector  NTI  Suite,  ContigExpress, Software Solution for Bio-Medicine
(SSBM).  We  have  pledged our trademarks to PNC Bank, National Association as a
security for the facilities under our loan agreement.


     Two  oppositions to our CTM trademark application for Vector NTI Suite have
been  filed. We negotiated a settlement of one opposition and are in the process
of  negotiations  to  settle  the  other opposition. We believe that an amicable
settlement can be reached.



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<PAGE>

     Additional  trademark  registrations  in  France  for  the  marks  Align.X,
Vector.NTI,  and  Software  Solution  For Bio-Medicine, among others, are in the
process of being assigned to us by our wholly-owned French subsidiary.

     We  believe  that the source code for our proprietary software solutions is
protected  under applicable copyright and trade secret law in the United States.
Comparable  and  effective  copyright  and  trade  secret  protection may not be
available in each country where we distribute our products.


     We  regularly  enter  into  confidentiality  agreements with our employees,
consultants,  and strategic partners and generally seek to control access to and
distribution  of our software, documentation, and other proprietary information.
We  may  nonetheless  be  subject  to  unauthorized  access  to, and use of, our
software  products. In addition, third parties may be able to develop technology
substantially  similar  to  our  existing  and  future software solutions. These
events  could materially affect our business, financial condition and results of
operations.



EMPLOYEES


     As  of  August  23,  2000,  we  had  192  full-time employees, including 90
employees  primarily  engaged  in  research and product development, 51 in sales
and  marketing  and 23 in implementation and support. We believe that our future
success  will  depend  in  part  on  our continued ability to attract and retain
qualified  personnel.  Competition for these personnel is intense, and there can
be  no  assurance  that  we  will be successful in attracting or retaining these
personnel  in the future. None of our employees is currently represented under a
collective  bargaining  agreement,  and we consider relations with our employees
to be good.



FACILITIES

     We  currently  lease  approximately  24,400 square feet of office space for
our  headquarters  in  Rockville,  Maryland for approximately $620,000 per year,
subject  to  an  annual  three  percent  rent escalation. The term of this lease
expires  in  July  2006.  We  maintain  additional  offices  in  Annapolis,  San
Francisco,  Denver,  and  Oxford,  England,  and  have  sales representatives in
Boston  and  Bonn,  Germany.  We believe that we will be able to obtain suitable
additional or substitute space as necessary at commercially reasonable rates.


LEGAL PROCEEDINGS

     We are not currently a party to any material legal proceedings.

                                       51
<PAGE>

                                  MANAGEMENT

DIRECTORS AND EXECUTIVE OFFICERS


     Our  executive  officers, key employees and directors, and their ages as of
the date of this prospectus, are as follows:




<TABLE>
<CAPTION>
NAME                             AGE  POSITION
------------------------------- ----- -----------------------------------------------------
<S>                             <C>   <C>
Alex Titomirov, Ph.D ..........  40   Chairman of the Board of Directors, President and
                                      Chief Executive Officer
James Bernstein, M.D ..........  61   Director, Chief Operating Officer and Executive Vice
                                      President, Strategic Development
Vadim Babenko, Ph.D ...........  38   Chief Technology Officer and Senior Vice President,
                                      Research and Product Development
Joseph Lehnen .................  40   Chief Financial Officer
Timothy Sullivan ..............  40   Senior Vice President, Marketing and Sales
Richard Melzer ................  44   Vice President, Global Sales
Dean Goddette, Ph.D ...........  42   Vice President, Marketing
Peter Covitz, Ph.D ............  35   Director of Implementation and Support Services
Hooks Johnston ................  38   Director
Harry D'Andrea ................  44   Director
Andrew Whiteley ...............  42   Director
Wei Wu He, Ph.D ...............  35   Director
</TABLE>



----------
     Alex  Titomirov,  Ph.D.,  is  the founder of InforMax and has served as our
President,  Chief Executive Officer and Chairman of the Board of Directors since
our  inception  in  1990.  Dr.  Titomirov  is  also the Chairman of the Board of
Directors  of  RealTimeHealth.com,  Inc., a development stage company monitoring
genetic  profiles  over  the Internet. Prior to founding InforMax, Dr. Titomirov
participated   in  research  on  the  developmentally  regulated  expression  of
mammalian  cells  for  gene  targeting  at the Laboratory of Mammalian Genes and
Development  at  the  National  Institutes  of  Health.  Upon his arrival in the
United  States  in  1989,  Dr.  Titomirov  served as a visiting scientist at the
Department  of  Microbiology  at Columbia University. While in the former Soviet
Union,  Dr.  Titomirov served as Group Leader of a research team in the field of
DNA  transfer  technology  at  the Institute of Molecular Biology in Moscow, and
served  as  Head  of  Theoretical  Seminars  at  the  Laboratory  of  Functional
Morphology  of  Chromosomes.  Dr.  Titomirov  has also served as a member of the
Grant  Committee  of  the  Russian  Academy of Sciences and an instructor at the
Moscow   Physical  Technical  Institute.  Dr.  Titomirov  earned  his  Ph.D.  in
Molecular  Genetics  in  1986 from the Institute of Cytology, Russian Academy of
Sciences  in  St. Petersburg, Russia, and his M.S. in Molecular Genetics in 1982
from St. Petersburg State University.

     James  Bernstein, M.D., has served as a director since our inception and as
our   Chief   Operating  Officer  and  Executive  Vice  President  of  Strategic
Development  since  1998.  Dr.  Bernstein is a founder and director of Age Wave,
L.L.C.,  a  holding company that develops businesses driven by population aging,
and  Chairman  of  Age  Wave  Impact,  Inc.,  a  relationship  marketing company
focusing  on  the  50+  population. From 1995 to 1997, Dr. Bernstein served as a
consultant  at  Age Wave, L.L.C. From 1989 to 1994, Dr. Bernstein was engaged in
the  development  of  a  private company for the distribution of pharmaceuticals
and  over-the-counter  medicines  in the former Soviet Union. Dr. Bernstein is a
founder  and  former  Chief  Executive  Officer  of  General  Health,  Inc.,  an
information  publishing  company  in  the  field  of  health risk assessment and
management.  Dr.  Bernstein  has  served as a special consultant to the National
Heart,  Lung  and  Blood  Institute  of the National Institutes of Health with a
focus  on  disease  prevention,  control  and  physician education. Prior to his
tenure  at  NIH,  he  was  a Deputy Director of the Georgetown University Health
Policy  Center.  From  1972  to  1974,  Dr.  Bernstein  headed the office of the
Chairman  of  the Board of Supervisors of San Diego County, California. Prior to
his  government service, Dr. Bernstein was a research associate and Assistant to
the  President  of  the  Salk Institute. Dr. Bernstein received his M.D. in 1964
from  Cornell  University Medical College and his Bachelor's degree in 1960 from
Harvard University.

     Vadim  Babenko,  Ph.D.,  has  served  as  our  Chief Technology Officer and
Senior  Vice  President  of Research and Product Development since our inception
in 1990. Dr. Babenko directs our research and



                                       52
<PAGE>


product  development  team,  having  designed  our  first  product  offering and
directed  all subsequent enhancements. Before arriving in the United States from
the  former  Soviet  Union,  Dr.  Babenko  was  the  Development  Team Leader at
GenInform,  Inc.,  Moscow, where he designed and managed development of software
for  genetic  engineering simulation. Prior to this, he served for five years as
a  Senior Scientist at the Institute of Molecular Genetics at the Soviet Academy
of  Sciences  conducting  research  on  genetic  data  analysis, protein and DNA
modeling,  and  computer  simulation  of  biological  processes using artificial
intelligence  techniques.  Dr.  Babenko has managed a number of research groups,
led  several  international collaborations, and authored over 30 publications in
the  fields of bioinformatics and artificial intelligence. Dr. Babenko also held
an  appointment  as  a  Senior Scientist at the Institute of Informatic Problems
where  he developed original methods for applying systems to medical diagnostics
and  decision  making.  Dr.  Babenko  earned  a  Ph.D.  in biophysics in 1990, a
Master's  degree  in  Theoretical  Physics  in  1985, and a Bachelor's degree in
Automatics  and  Telemechanics  in  1983,  each  from  the  Moscow  Institute of
Physical  Technology.  He  was  cited Outstanding Young Scientist in 1989 at the
Soviet  Academy  of  Sciences,  Outstanding  Researcher  in  1987  by the Soviet
Association  of  Artificial Intelligence, and Best Student Researcher in 1984 by
the Moscow Institute of Physical Technology.


     Joseph  Lehnen  has  served  as  our  Chief Financial Officer since January
1999.  Prior  to joining InforMax, Mr. Lehnen spent eight years as an investment
banker  with  J.P. Morgan & Co., working with health care sector clients ranging
from  early-stage  companies  to  Fortune 100 corporations. His experience as an
investment  banker  included  financing  transactions  in the public and private
markets,   merger   and  acquisition  execution,  industry  analysis,  strategic
advisory  work  and financial risk analysis. Prior to his tenure at J.P. Morgan,
Mr.  Lehnen  held  positions as an aide in the U.S. Senate and as a radar design
engineer  for  Litton  Industries'  defense  contracting  division.  Mr.  Lehnen
received  a  Master's degree in public policy from Harvard University in 1989, a
Master's  degree in physics from Yale University in 1985 and a Bachelor's degree
in physics from Santa Clara University in 1982.

     Timothy  Sullivan  has  served  as our Senior Vice President of Marketing &
Sales  since  January  1999.  Prior  to  joining  InforMax,  Mr.  Sullivan  held
positions  in  product  management,  alliance  management,  and  major  accounts
management  at  Manugistics,  Inc.,  a  supply-chain  decision  support software
vendor,  from  1995  to  1999.  Prior to his tenure at Manugistics, Mr. Sullivan
served  as product manager at TSI Software International, an electronic commerce
vendor,  from  1993  to  1995.  Mr.  Sullivan  previously served as a management
consultant  with  Andersen  Consulting  and  Booz-Allen  &  Hamilton.  Prior  to
entering  the  private  sector  in 1988, Mr. Sullivan was a Platoon Commander in
the  United  States Marine Corps. He received an M.B.A. in Marketing in 1992 and
a Bachelor's degree in Classics in 1984, each from Columbia University.


     Richard  Melzer  has  served  as  our  Vice President of Global Sales since
January  2000.  Mr.  Melzer  previously served as our enterprise account manager
from  April  1999 to December 1999. Prior to joining InforMax, Mr. Melzer served
as  a  senior  account  manager  for  Manugistics, Inc., a supply-chain decision
support  vendor,  from  April 1994 to March 1999. From April 1984 to March 1994,
Mr.  Melzer  served  in  a  number  of  positions  including  Vice President and
Managing  Director  of  European, Middle Eastern and African operations and Vice
President  of  Sales  and  Operations  for DISC, Inc., a NYNEX Company that sold
application  software  to major banks, corporations and insurance companies. Mr.
Melzer  received Bachelor's degrees in International Relations and Multinational
Enterprise from the Wharton School of the University of Pennsylvania in 1978.

     Dean  Goddette,  Ph.D., has served as our Vice President of Marketing since
June  2000.  Prior  to  joining  InforMax, Dr. Goddette held positions including
Vice  President of Marketing and Sales and Vice President of Bioinformatics with
Structural  Bioinformatics,  Inc.  from  August 1998 to June 2000. From December
1993  to  August  1998, Dr. Goddette held positions including Manager of central
U.S.   and  Canada  sales  and  Senior  Product  Manager  for  Tripos,  Inc.,  a
pharmaceutical  and  biotechnology  software  and services company. Dr. Goddette
received  a  Ph.D. in Biochemistry from Washington University School of Medicine
in  1996  and  a  Bachelor's degree in Protein Biophysics from the University of
Connecticut in 1980.

     Peter  Covitz,  Ph.D,  has  served  as  our  Director of Implementation and
Support  Services  since  September  1999.  Dr.  Covitz coordinates our software
integration,  customization, maintenance, support and training efforts. Prior to
joining InforMax, Dr. Covitz led the microarray gene expression



                                       53
<PAGE>

software   team  at  Molecular  Applications  Group,  a  bioinformatic  software
company,  from  September  1998  to August 1999. From March 1997 to August 1998,
Dr.  Covitz  served  as  a  senior product scientist for Incyte Pharmaceuticals,
Inc.  where  he worked with the development of a classification system for their
sequence  databases.  Dr.  Covitz received a Ph.D. in Microbiology from Columbia
University  in  1993  and a Bachelor's degree in Biology from Colgate University
in 1986.


     Hooks  Johnston  has served as a director since June 1999. Mr. Johnston has
been  Managing  Director  of  FBR Technology Venture Partners, a venture capital
investment  firm,  since December 1998. From November 1997 to December 1998, Mr.
Johnston  served  as  the President of Descartes Systems Group, a leading supply
chain  software  company, which he assisted in taking public in early 1998. From
September  1995 to November 1997, Mr. Johnston served as the President and Chief
Executive  Officer  of  Roadshow  International, Inc., a transportation software
company  that was acquired by Descartes. From August 1993 to September 1995, Mr.
Johnston  was  the Chief Operating Officer of ALG, Inc., a design, pre-press and
web  development  services  company. Mr. Johnston currently serves on the boards
of  directors  of  Intranets.com,  Inc.,  MarketSwitch  Corporation, B2Emarkets,
Inc.,  Shop2u,  Inc.,  Radiowave.com,  Inc.,  Collaborex, Inc., Global Logistics
Technologies,  Inc.  and  Shelflink,  Inc.  Mr. Johnston received an M.B.A. from
Harvard  Business  School  in  1988, and a Bachelor of Science degree in Applied
Mathematics and Economics from Brown University in 1984.

     Harry  D'Andrea  has served as a director since June 1999. Mr. D'Andrea has
been  the  Chief Financial Officer of Advanced Switching Communications, Inc., a
telecommunications  equipment  provider,  since  June  1999. From August 1998 to
June  1999, Mr. D'Andrea served as Chief Financial Officer of Call Technologies,
inc.,  a  telecommunications software provider. From June 1997 to July 1998, Mr.
D'Andrea  served  as  Chief Financial Officer of Yurie Systems, Inc., a provider
of  networking and telecommunications equipment. In 1996, Mr. D'Andrea served as
Chief  Financial  Officer of American Communications Services, Inc., now e.spire
Communications,  Inc.,  a telecommunications service provider. Prior to that Mr.
D'Andrea  served  as  Executive  Vice  President,  Chief  Financial  Officer and
Treasurer   of  Caterair  International  Corporation,  a  provider  of  catering
services  for commercial airlines. Mr. D'Andrea currently serves on the board of
directors  of  Coagulation  Diagnostics, Inc. Mr. D'Andrea received an M.B.A. in
Finance  from  Drexel  University  in  1980  and  a Bachelor's degree in Foreign
Service from Pennsylvania State University in 1978.

     Andrew  Whiteley has served as a director since August 2000.  Mr.  Whiteley
has been the Vice President of Bioinformatics  for Amersham  Pharmacia  Biotech,
Inc., a provider of integrated  drug  discovery  solutions,  since January 2000.
From October 1997 to December  1999,  Mr.  Whiteley  served as Vice President of
Amersham Pharmacia Biotech's  sequencing  business.  For a portion of the period
above,  Mr.  Whiteley  also served as site  director for Amersham  International
PLC's  Cleveland  facility.  From April 1995 to March 1997, Mr. Whiteley was the
head of Amersham  International's  group  marketing.  Mr. Whiteley serves on the
board of directors of Cimarron  Software  Services,  Inc. and Imaging  Research,
Inc. Mr.  Whitely  received a Bachelor's  degree in chemistry  and  biochemistry
from Nottingham University in the U.K. in 1980.

     Wei-Wu  He,  Ph.D., has served as a director since August 2000. Since March
2000,  Dr. He has served as the General Partner of Emerging Technology Partners,
L.L.C.,  a  venture  capital  fund  he founded that is dedicated to investing in
genomics  technology  companies.  In  1996,  Dr. He founded OriGene Technologies
Inc.,  a  provider  of genomics technologies for the pharmaceutical industry and
served  as  President from June 1996 to March 2000. From 1993 to 1996 Dr. He was
a  scientist  at Human Genome Sciences, Inc. and prior to that he was a research
fellow  at  Massachusetts  General  Hospital. Additionally, Dr. He serves on the
Board  of Directors of numerous organizations such as the Chinese Pharmaceutical
Association,  of which he was elected President in 2000, the Scientific Advisory
Board  of F & S Inc., the Monte Jade Association, and Aptus Genomics Inc. Dr. He
received  his  Ph.D. in Molecular Biology from the Baylor College of Medicine in
1991  and  a  Bachelor's degree in Biochemistry from Nanjing University in 1985.
Dr.  He  also  received  an  M.B.A. from The Wharton School of the University of
Pennsylvania in 1999.



                                       54
<PAGE>

BOARD STRUCTURE


     Our  bylaws  currently  provide  for a board of directors consisting of not
more  than  seven  members,  to  be  fixed  from  time  to  time by our board of
directors.  All  directors  hold  office  until  the  next annual meeting of our
stockholders  and  until  their  successors  have  been elected and qualified or
until  their  earlier  resignation  or  removal.  Messrs. Johnston, D'Andrea and
Whiteley  were  elected to the board of directors under a voting agreement among
us,  FBR  Technology Venture Partners II, LP, Amersham Pharmacia Biotech and our
other   principal  stockholders.  This  voting  agreement  will  terminate  upon
completion of this offering.


     In  accordance  with  the  terms of our amended and restated certificate of
incorporation  to  be  effective  upon completion of this offering, the board of
directors  will be divided into three classes, each serving staggered three-year
terms, following the completion of this offering:


     o Class I, whose initial term will expire at the annual meeting, or special
       meeting held in lieu of an annual meeting, of stockholders held in 2001;

     o Class II,  whose initial  term  will  expire  at  the  annual meeting, or
       special meeting held in lieu of an annual meeting,  of stockholders  held
       in 2002; and

     o Class III, whose  initial  term  will  expire  at  the annual meeting, or
       special meeting held in lieu of an annual meeting,  of stockholders  held
       in 2003.

As  a result, only one class of directors will be elected at each annual meeting
of  stockholders of InforMax with the other classes continuing for the remainder
of  their  respective  terms.  Mr.  D'Andrea  and Dr. He have been designated as
Class  I directors; Mr. Johnston and Dr. Bernstein have been designated as Class
II  directors;  and Dr. Titomirov and Mr. Whiteley have been designated as Class
III  directors.  These  provisions  in  our  amended and restated certificate of
incorporation  may  have the effect of delaying or preventing changes in control
or management of InforMax.



BOARD COMMITTEES


     We  have  two  standing  committees:  a compensation committee and an audit
committee.  The  compensation  committee  currently consists of Messrs. Johnston
and D'Andrea. The compensation committee:


     o reviews and approves  the  compensation  and  benefits  for our executive
       officers and grants stock options under our equity incentive compensation
       plan; and

     o makes recommendations to the board of directors regarding these matters.



     The  audit  committee consists of Messrs. Johnston, D'Andrea, and Whiteley.
The audit committee:


     o makes recommendations to  the  board of directors regarding the selection
       of independent auditors;

     o reviews the results and scope of the audit and other services provided by
       our independent auditors; and

     o reviews and evaluates our audit and control functions.


COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION


     No  executive  officer  of  InforMax  serves  as  a  member of the board of
directors  or  compensation  committee  of  any  entity  that  has  one  or more
executive  officers serving on our board of directors or compensation committee.




                                       55
<PAGE>

COMPENSATION OF DIRECTORS

     Directors  do  not receive cash compensation for their service on our board
of  directors or any board committee. In 1999, we granted Mr. D'Andrea an option
to  purchase  15,000  shares  of our common stock at an exercise price of $0.50.
Such  options  are  subject  to  conditions  relating  to  vesting and continued
participation  on  our  board  of directors. We reimburse non-employee directors
for  their  reasonable  expenses incurred in connection with their attendance at
meetings  of  our  board of directors and board committees and may in the future
issue options to non-employee directors upon:

     o appointment, election, or re-election to the board; and

     o each anniversary thereof if he or she continues to serve as a director.



SCIENTIFIC ADVISORY BOARD

     We  have  recruited  a  scientific advisory board consisting of individuals
with   expertise   in   genomics,  bioinformatics,  information  technology  and
pharmaceutical  discovery.  Our  scientific  advisory board was assembled during
the  second  quarter  of  2000  and we anticipate consulting with our scientific
advisory board regarding industry and scientific developments.



<TABLE>
<CAPTION>
                  NAME                                   POSITION AND ORGANIZATION
---------------------------------------- ---------------------------------------------------------
<S>                                      <C>
Michael N. Liebman, Ph.D ............... Global Head, Computational Genetics, Roche
                                         Biosciences
Jacquelyn S. Fetrow, Ph.D .............. Chief Scientific Officer, GeneFormatics, Inc.
Rainer Fuchs, Ph.D ..................... Vice President, CIO, Ariad Pharmaceuticals, Inc.
Lawrence M. Kanvar, Ph.D ............... President, Trellis Bioinformatics, Inc.
Dorn Lancet, Ph.D ...................... Professor of Neurogenomics, Weizmann Institute
                                         Crown Human Genome Center
F. Raymond Salemme, Ph.D ............... President and CSO, 3-Dimensional Pharmaceuticals,
                                         Inc.
Robert Strausberg, Ph.D ................ Assistant to the Director of National Cancer Insititute,
                                         National Institutes of Health
John N. Weinstein, M.D., Ph.D .......... Group Chief of National Cancer Institute, National
                                         Institutes of Health
Arthur L. Williams, Ph.D ............... Executive Director Pharmaceutical Development
                                         Informatics, Bristol-Myers Squibb
George Maalouf, Ph.D ................... Former Director, Computational Biology, Compaq
                                         Computer Corporation
Raymond Cho ............................ Vice President of Genomics, InGenuity Systems
</TABLE>


KEY MAN INSURANCE


     We  maintain  "key  man" life insurance in the amount of $2,000,000 on each
of Dr. Titomirov and Dr. Babenko, with proceeds payable to us.


EMPLOYMENT AGREEMENTS

     On  August  14,  2000,  Dr.  Alex Titomirov provided us a commitment letter
regarding  his  continued  service  with  us.  Under  the commitment letter, Dr.
Titomirov  agreed  to  devote  to  us  at  least  a majority of his professional
working time for a period equal to the longer of (1) 18 months



                                       56
<PAGE>


from  the  date  of  this  prospectus, provided such date does not extend beyond
August  14,  2003, or (2) August 14, 2002. This commitment is conditioned on his
salary  continuing at a rate not less than his current salary and his receipt of
bonuses   commensurate  with  those  received  by  our  senior  management.  Dr.
Titomirov  has  further agreed that for a period of two years after he ceases to
be  an  officer,  employee  or 10% holder of our outstanding shares, he will not
directly  render  services  for any business engaged in such business activities
that  we are involved in at the time of his termination or which are anticipated
and  have  been  approved  by our board of directors by that time. Dr. Titomirov
has  also  agreed  that  for such two year period he will not hire or attempt to
hire  any  of  our employees, or persons that were employed by us during the one
year  period  prior  to  his ceasing to be an officer, employee or 10% holder of
our outstanding shares.

     In  July  2000, we entered into an employment agreement with Vadim Babenko,
to  serve as our Chief Technology Officer through July 14, 2002. The term of Dr.
Babenko's  employment  automatically  renews  for  successive  one  year periods
unless  and  until  either  party provides written notice, not less than 90 days
prior  to  the  end  of  the  then  current  term, of their intent not to renew.
Pursuant  to  this agreement, Dr. Babenko's salary was set at $285,000 per year,
with  eligibility for increases and bonuses as determined by the Chief Executive
Officer  and  our board of directors. In the event that Dr. Babenko's employment
is  terminated  by  us  without  cause, he will receive a lump sum payment of an
amount  equal  his  then  effective annual salary. Dr. Bakenko has agreed not to
compete  with  us  or solicit our employees during the term of our agreement and
for a period of two years following the termination of this agreement.

     In  April 1999, we entered into an employment agreement with Joseph Lehnen,
to  serve  as  our  Chief  Financial  Officer  and Senior Vice President through
December  31, 2002. The term of Mr. Lehnen's employment automatically renews for
successive  one  year  periods  unless  and  until either party provides written
notice,  not  less  than  90  days prior to the end of the then current term, of
their  intent  not  to  renew.  Pursuant to this agreement, Mr. Lehnen's initial
salary  was  set  at  $150,000  per year, with eligibility for bonuses and stock
options  as  determined  by  the  Chief  Executive  Officer  and  our  board  of
directors.  In  the  event  that  Mr.  Lehnen's  employment  is terminated by us
without  cause,  or  terminated  by  Mr. Lehnen as a result of our breach of his
employment  agreement,  he  will receive an amount equal to fifty percent of his
salary  and  bonus  for  the  previous  12  month  period. In the event that Mr.
Lehnen's  employment  is terminated without cause upon, or within one year of, a
change  of control of our company, he will receive an amount equal to his salary
and  bonus  for  the  previous  12 month period. In the event that Mr. Lehnen is
terminated  for  cause  or  voluntarily  resigns  without  breach  by  us of our
agreement,  he  has agreed not to compete with us or solicit our employees for a
period of 12 months following the cessation of his employment.

     In  April  1999,  we  entered  into  an  employment  agreement with Timothy
Sullivan,  to  serve  as our Senior Vice President, Marketing and Sales, through
March  31,  2003. The term of Mr. Sullivan's employment automatically renews for
successive  one  year  periods  unless  and  until either party provides written
notice,  not  less  than  90  days prior to the end of the then current term, of
their  intent  not  to renew. Pursuant to this agreement, Mr. Sullivan's initial
salary  was  set at $150,000 per year plus monthly commissions of one percent of
that  month's  software license and professional services revenues. In the event
that  Mr. Sullivan's employment is terminated by us without cause, or terminated
by  Mr.  Sullivan as a result of our breach of his employment agreement, he will
receive  an  amount  equal to fifty percent of his salary and earned commissions
for  the  previous  12 month period. In the event that Mr. Sullivan's employment
is  terminated without cause upon, or within 180 days of, a change of control of
our  company,  he  will  receive an amount equal to his annual salary and earned
commissions  for the previous 12 month period. In the event that Mr. Sullivan is
terminated  without  cause, other than upon a change of control, or Mr. Sullivan
terminates  his  employment  as  a  result  of  our  breach  of  his  employment
agreement,  he  has agreed not to compete with us or solicit our employees for a
period  of  six  months  following the cessation of his employment. In the event
that  Mr.  Sullivan's  employment  is  terminated  for  any other reason, he has
agreed  not  to  compete  with  us  or  solicit our employees for a period of 12
months following the cessation of his employment.



                                       57
<PAGE>

EXECUTIVE COMPENSATION

     The  following table sets forth compensation awarded to, earned by, or paid
to  our  Chief  Executive  Officer  and  the  four other most highly compensated
executive  officers  whose  total cash compensation exceeded $100,000 during the
year ended December 31, 1999.


                          SUMMARY COMPENSATION TABLE





<TABLE>
<CAPTION>
                                                                               LONG-TERM
                                           ANNUAL COMPENSATION               COMPENSATION
                                 ---------------------------------------   ----------------
                                                                              SECURITIES
                                                                              UNDERLYING
NAME AND PRINCIPAL POSITION       YEAR          SALARY           BONUS          OPTIONS
------------------------------   ------   -----------------   ----------   ----------------
<S>                              <C>      <C>                 <C>          <C>
Dr. Alex Titomirov,              1999        $  300,000          0            3,899,900
 Chief Executive Officer and
   Chairman of the Board of
   Directors
Dr. Vadim Babenko,               1999        $  200,000          0            1,600,000
 Chief Technology Officer and
   Senior Vice President
Dr. James Bernstein,             1999        $  225,000          0            1,050,000
 Chief Operating Officer and
   Executive Vice President
Joseph Lehnen,                   1999        $  145,000(1)    $35,000           350,000(2)
 Chief Financial Officer
Timothy Sullivan,                1999        $  222,747(3)       0              375,000(4)
 Senior Vice President,
   Marketing and Sales
</TABLE>


(1) Under  the  terms of his April 1999 employment agreement Mr. Lehnen's annual
salary is $150,000.

(2) Does not include 167,000 options granted on January 1, 2000.

(3) Includes $72,747 in commissions based on the sale of our software products.

(4) Does not include 292,250 options granted on January 1, 2000.


                                       58
<PAGE>

OPTIONS GRANTS DURING 1999


     All  of the following stock options were granted under our equity incentive
plan  and  are exercisable for shares of our common stock. The percentages below
are  based  on a total of 14,932,487 shares subject to options we granted during
the  year  ended December 31, 1999 to our employees, directors, and consultants,
including the executive officers named in the Summary Compensation Table.

     The  exercise  price  per  share of each option is equal to the fair market
value  of  the  common stock as determined by the board of directors on the date
of  grant.  The potential realizable value is based on an assumed initial public
offering  price  of  $15.00  per  share, the midpoint of the offering range. The
calculations  below assume that the price of our common stock increases from the
date  of  grant  until the end of the ten-year option term at the assumed 5% and
10%  rates. These assumed rates are calculated based on rules promulgated by the
Securities  and  Exchange  Commission  and  do  not  reflect  future stock price
growth.  The actual value realized may be greater or less than the assumed rates
illustrated in the table.



                       OPTION GRANTS IN LAST FISCAL YEAR


<TABLE>
<CAPTION>
                          NUMBER OF     PERCENT OF                                     POTENTIAL REALIZABLE
                           SHARES          TOTAL       EXERCISE                          VALUE AT ASSUMED
                         UNDERLYING       OPTIONS        PRICE                        ANNUAL RATES OF STOCK
                           OPTIONS      GRANTED TO        PER       EXPIRATION        PRICE APPRECIATION FOR
                           GRANTED       EMPLOYEES       SHARE         DATE                OPTION TERM
                        ------------   ------------   ----------   ------------   ------------------------------
                                                                                        5%              10%
NAME
<S>                     <C>            <C>            <C>          <C>            <C>             <C>
Dr. Alex Titomirov       6,512,833          43.6%       $ .30       3/20/2009      $9,769,250      $19,538,499
Dr. Vadim Babenko        2,672,000          17.9%       $ .30       3/20/2009      $4,008,000      $ 8,016,000
Dr. James Bernstein      1,753,500          11.7%       $ .30       3/20/2009      $2,630,250      $ 5,260,500
Joseph Lehnen              584,500           3.9%       $ .30       3/24/2009      $  876,750      $ 1,753,500
Timothy Sullivan           626,250           4.2%       $ .30       3/24/2009      $  939,375      $ 1,878,750
</TABLE>


AGGREGATE OPTION EXERCISES DURING 1999 AND YEAR-END OPTION VALUES

     The  following  table provides summary information concerning the shares of
common  stock  represented  by  outstanding  stock  options  held by each of the
executive  officers  named  in the Summary Compensation Table as of December 31,
1999.

     The  value realized represents the difference between the fair market value
of  the  shares  as of December 31, 1999, based on the assumed fair market value
of $2.00 per share, and the exercise price of the option.






<TABLE>
<CAPTION>
                             NUMBERS OF SECURITIES
                            UNDERLYING UNEXERCISED         VALUE OF UNEXERCISED IN-THE-
                                  OPTIONS AT                     MONEY OPTIONS AT
                                FISCAL YEAR END                  FISCAL YEAR END
                        -------------------------------   ------------------------------
                         EXERCISABLE     UNEXERCISABLE     EXERCISABLE     UNEXERCISABLE
<S>                     <C>             <C>               <C>             <C>
Dr. Alex Titomirov        6,512,833               0        $5,849,850               0
Dr. Vadim Babenko         3,340,000               0        $3,196,000               0
Dr. James Bernstein       1,780,220               0        $1,606,840               0
Joseph Lehnen               347,049         237,451(1)     $  311,721        $213,279
Timothy Sullivan            169,601         456,648(1)     $  152,337        $410,163
</TABLE>



(1) Subsequent  to  December  31,  1999,  the vesting of the covered options has
    been  accelerated  such  that  all  options  are  currently  exercisable  by
    Messrs. Lehnen and Sullivan.



                                       59
<PAGE>


EQUITY INCENTIVE COMPENSATION PLAN


     Administration


     We  established  our  equity  incentive  compensation  plan, as amended, in
order  to  provide  incentives  for our eligible officers, employees, directors,
and  consultants  to  improve  our  business  results, by giving such persons an
opportunity  to  acquire  or increase their proprietary interest in us. Our plan
also  better  enables  us  to  attract,  retain, and reward talented and skilled
personnel.

     Our  plan  may  be  administered  by  our  board  of  directors  or a board
committee.  Subsequent  to  this  offering, our plan will be administered by the
compensation  committee  of  our board of directors, which will include at least
two  "disinterested persons," for purposes of Rule 16b-3 under the Exchange Act,
and  "outside  directors,"  within the meaning of Section 162(m) of the Internal
Revenue  Code  of  1986. The administrator has authority to take all actions and
make all determinations required or provided for under our plan, including:

     o determination of the terms of any options or other awards granted;

     o the exercise price of the option or other award;

     o the number of shares subject to each option or other award;

     o the exercisability and vesting thereof;

     o and the form of consideration payable upon such exercise.

Moreover,  the administrator may rescind, modify or waive certain limitations or
conditions  associated  with  a  grant  under  the  plan so as to accelerate the
exercise  period.  The total number of shares of our common stock authorized for
use  by  the  plan  is  6,179,000.  As  of  August 23, 2000, options to purchase
13,470,517  shares  of  our  common  stock and 60,000 shares of restricted stock
were  granted  including  5,185,735  shares of common stock issuable pursuant to
incentive awards under the plan.


     Stock Options


     The  plan  provides for the discretionary grant of incentive stock options,
within  the  meaning  of  Section  422 of the Internal Revenue Code, and for the
grant  of non-qualified stock options. The exercise price of all incentive stock
options  granted  under  our  plan  must  be  at least equal to 100% of the fair
market  value  of  the  shares underlying the options on the date of grant. With
respect  to  any  participant  who  owns  stock  possessing more than 10% of the
voting  power  of  all  classes  of  our outstanding capital stock, the exercise
price  of  any  incentive stock option granted must be at least equal to 110% of
the  fair  market  value  on the grant date and the term of such incentive stock
option  must not exceed five years. Under our plan, an option will constitute an
incentive  option only to the extent that the aggregate fair market value of the
underlying  stock,  at  the  time of the option grant, does not exceed $100,000.
The  exercise  price  of any stock options issued under our plan may not be less
than  the  par  value of the underlying common stock. The term of options issued
under our plan may not exceed ten years.


     Restricted Stock


     Under  our  plan,  the administrator may grant to such eligible individuals
shares  of  our  restricted common stock, subject to the recipient's both paying
not  less  than  the  par value of such common stock and attaining or completing
any  performance  objectives  and  service requirements upon which such grant is
conditioned.  Upon  the  recipient's  non-payment of the price specified for the
shares,  failure to attain the performance objectives prior to expiration of the
specified  period,  or  termination  of  employment without having satisfied the
service  requirement, the shares of restricted stock, or the appropriate portion
thereof,  will be forfeited and will again be available for reissuance under the
terms of our plan.

     Transferability

     Options  and  other  awards  granted  under  our  plan  are  generally  not
transferable  by  the recipient. Awards granted under the plan must generally be
exercised  within  six  months  after a recipient's death or permanent and total
disability, but in no event later than the expiration of



                                       60
<PAGE>


the  option's term. Except as may be provided by the administrator in the option
agreement  or  restricted  stock  agreement,  upon  termination of employment or
service,  other  than  by  reason  of  death  or permanent and total disability,
shares  of  restricted  stock  and options that have not become vested under the
plan  will  terminate  and  the  recipient thereof will have no further right to
purchase  the  covered  shares  of  common  stock.  Upon  the termination of the
recipient's  employment or service for any reason, we will have the right, for a
period  of  180 days following such termination, to repurchase any or all of the
shares  acquired  by the recipient pursuant to an incentive award under the plan
at  either the fair market value of such shares on the date of termination, or a
lower price as specified in an agreement at the time of grant.


     Change in Capitalization, Merger or Sale


     The  number  and  price  of shares covered by outstanding stock options and
restricted   stock  awards  granted  under  the  plan  will  be  proportionately
adjusted,  as  determined  by  our  board of directors, to take into account any
recapitalization,   stock   split,   reverse   stock   split,   stock  dividend,
combination,  exchange  or reclassification of shares or similar event. The plan
provides that if we:

     o liquidate,  dissolve,  merge,  consolidate  or  reorganize  with  another
       company in which we are not the surviving entity;

     o sell substantially all of our assets to another company; or

     o approve a transaction  that results in any person or entity owning 80% or
       more of the voting power of all classes of our stock, other than existing
       stockholders at the time our plan was approved, and their affiliates,

then  all options outstanding under the plan will terminate if the option is not
assumed  by  the  surviving  corporation,  its  parent or subsidiary, or if such
entities  do  not  substitute another award reflecting an appropriate adjustment
to  the number and price of such covered shares. In the event that the option is
terminated  as  a  result of the transactions above, the holder will be given an
opportunity  to  exercise  the vested portion of the option immediately prior to
the option's termination.



                                       61
<PAGE>


                             CERTAIN TRANSACTIONS


SERIES B CONVERTIBLE PREFERRED STOCK FINANCING

     On  August 16, 2000, we sold 950,747 shares of our Series B preferred stock
to  Amersham  Pharmacia  Biotech,  Inc.  in  connection with the creation of our
strategic  relationship. We sold the preferred stock at approximately $10.52 per
share,  for  aggregate  proceeds  to us of $10 million in cash. We expect to use
the   proceeds   for   general  working  capital  purposes.  These  shares  will
automatically  be  converted  into 1,587,747 shares of our common stock upon the
closing  of  this  offering, with an aggregate value of $23,816,212, assuming an
initial  offering  price  of  $15.00  per  share.  Andrew  Whiteley,  one of our
directors,  is  the  Vice  President  of  Bioinformatics  of  Amersham Pharmacia
Biotech.

     In  connection  with  the  sale of preferred stock, we amended and restated
our  investor rights agreement to grant certain registration rights to Amersham.
In  the  event  that  we are able to effect a short form registration, Amersham,
subject  to  certain  conditions,  may  require  us  to file such a registration
statement.  In  addition, Amersham is entitled to certain piggyback registration
rights  by which it can, subject to certain circumstances, include shares of its
common  stock in a registration statement filed by us. Amersham's short form and
piggyback  registration  rights  terminate  when  all  of its shares can be sold
under  Rule  144  in  any  90  day  period.  The  investor rights agreement also
contains  certain  restrictions  on Amersham's ability to transfer its shares of
our stock.



SERIES A CONVERTIBLE PREFERRED STOCK FINANCING


     On  June 22, 1999, we sold 2,161,265 shares of our Series A preferred stock
to  FBR  Technology  Venture  Partners II, LP, at approximately $1.85 per share,
for  aggregate  proceeds to us of $4 million in cash. The proceeds were used for
general  working  capital purposes. These shares will automatically be converted
into  3,609,312  shares  of  our common stock upon the closing of this offering,
with  an  aggregate  value  of $54,139,680 assuming an initial offering price of
$15.00  per  share. Hooks Johnston, one of our directors, is a managing director
of  FBR  Technology  Venture  Partners,  the  general  partner of FBR Technology
Venture Partners II, LP.

     In  connection  with  the  sale of our Series A preferred stock, we entered
into  an  investor rights agreement with FBR Technology Venture Partners II, LP,
which  was  amended and restated in August 2000, with respect to the granting of
certain   registration  rights.  FBR  was  granted  demand  registration  rights
pursuant  to which it may, subject to certain conditions, and beginning 180 days
from  the  date  of this prospectus, require us to file a registration statement
on  its  behalf  covering  shares  of  its  common  stock  on  not more than two
occasions.  These  rights expire five years from the date of this prospectus. In
the  event that we are able to effect a short form registration, FBR, subject to
certain  conditions,  may require us to file such a registration statement on up
to   four   occasions.  In  addition,  FBR  is  entitled  to  certain  piggyback
registration  rights  by which it can, subject to certain circumstances, include
shares  of its common stock in a registration statement filed by us. FBR's short
form  and  piggyback registration rights terminate when all of its shares can be
sold  under  Rule  144 in any 90 day period or if FBR's ownership falls below 1%
of our outstanding shares.

     The  investor  rights agreement also contains certain restrictions on FBR's
ability to transfer its shares of our common stock.



OTHER RELATED PARTY TRANSACTIONS


     In  1999,  Dr.  Titomirov,  our  President  and  Chief  Executive  Officer,
personally  guaranteed  an  equipment  loan  facility  of  ours in the amount of
$125,000. The outstanding balance was paid in full in 1999.

     In  1999,  Dr.  Titomirov personally guaranteed a line of credit of ours in
the amount of $400,000. The outstanding balance was paid in full in 1999.



                                       62
<PAGE>


     In  April  1999, we loaned $65,000 to Dr. Titomirov. The amount of the loan
was  secured by a promissory note to be repaid upon the fifth anniversary of the
date  of  the  loan.  Interest accrued at the prime rate as reported in The Wall
Street  Journal  plus  1%  and was due and payable on each anniversary until the
balance  of  the  note  was paid in full. The funds were loaned to Dr. Titomirov
for  payment  of  federal and state income taxes. The principal and interest due
thereon associated with this note were fully repaid in July 2000.

     In  June  1999, we granted Mr. D'Andrea, one of our directors, an option to
purchase  25,050  shares  of  our common stock at an exercise price of $0.30 per
share.  Such options are subject to conditions relating to vesting and continued
participation on our board of directors.

     In  March  2000,  Dr.  Titomirov entered into a private transaction for the
sale  of  835,000 shares to FBR Technology Venture Partners II, LP at $10.00 per
share.  In  March  2000,  Drs.  Titomirov  and  Babenko  entered  into a private
transaction  with  certain  of the Weiss, Peck & Greer entities disclosed in the
"Principal  Stockholders"  table  for  the  sale of 584,500 and 668,000 of their
shares  of  common  stock, respectively, at $5.99 per share. In June 2000, Drs.
Titomirov  and  Babenko  entered  into  a  private  transaction  for the sale of
835,000   and  275,550  of  their  shares  of  common  stock,  respectively,  at
approximately  $6.37  per  share  to  Paul  Capital  Partners  VI  Holdings. In
connection  with  these  transactions, Paul Capital Partners VI Holdings and the
Weiss,  Peck  & Greer entities became parties to our non-preferred holder rights
agreement  and  received  certain  registration rights. In the event that we are
able  to  effect  a  short  form registration, we may be required to file such a
registration  statement  on not more than two occasions. In addition, we granted
certain  piggyback registration rights by which the parties to the non-preferred
rights  agreement can, subject to certain circumstances, include shares of their
common  stock  in  a  registration  statement  filed by us. These short form and
piggyback  registration  rights  terminate  five  years  from  the  date of this
prospectus.  In addition, such rights shall earlier terminate if the shares of a
party  to  the  agreement  can be sold under Rule 144 in any 90 day period or if
their share ownership falls below a certain level.

     In  August  2000,  Dr. Bernstein entered into a private transaction with an
accredited  investor  for  the  sale of 83,900 shares of common stock, at  $6.30
per  share. In connection with this transaction, the purchaser joined as a party
to  our  non-preferred holder rights agreement and received certain registration
rights described above.

     We  believe  that  the  terms of each of the transactions described in this
section  are  no  less  favorable  to  us  than that we could have obtained from
disinterested third parties.



                                       63
<PAGE>

                            PRINCIPAL STOCKHOLDERS


     The  following  table  sets forth certain information as of August 23, 2000
for:


     o each person, entity,  or  group known by us to own beneficially more than
       5% of our outstanding common stock;

     o each named executive officer and each of our directors; and

     o our directors and executive officers as a group.


     Unless  otherwise  indicated,  the address of each person identified is c/o
InforMax, Inc., 6010 Executive Boulevard, 10th Floor, Rockville, MD 20852.

     The  percentages  shown  are  based  on  13,128,514  shares of common stock
outstanding  prior  to the offering as of August 23, 2000, and 18,128,514 shares
of  common  stock  outstanding  after the offering. A person is deemed as of any
date  to  have  "beneficial  ownership"  of  any security that such person has a
right  to  acquire  within 60 days after such date. Pursuant to Rule 13d-3 under
the  Exchange Act, shares of common stock that a person has the right to acquire
pursuant  to  the  exercise  of  stock  options  held  by  that  holder that are
exercisable  within  60  days  of August 23, 2000 are deemed outstanding for the
purpose  of  computing  the  percentage  ownership  of  that person, but are not
deemed  outstanding  for computing the percentage ownership of any other person.
Except  as  indicated  by footnote, and subject to community property laws where
applicable,  the  persons  named  in  the  table have sole voting and investment
power for all shares of common stock shown as beneficially owned by them.





<TABLE>
<CAPTION>
                                                         SHARES BENEFICIALLY        SHARES BENEFICIALLY
                                                                OWNED                      OWNED
                                                          PRIOR TO OFFERING           AFTER OFFERING
                                                       ------------------------   -----------------------
              NAME OF BENEFICIAL OWNER                    NUMBER       PERCENT       NUMBER       PERCENT
----------------------------------------------------   ------------   ---------   ------------   --------
<S>                                                    <C>            <C>         <C>            <C>
Alex Titomirov, Ph.D.(1) ...........................    6,112,200        35.2%     6,112,200        27.3%
FBR Technology Venture Partners II, LP(2) ..........    4,444,312        33.9%     4,444,312        24.5%
 1001 19th Street
 Arlington, VA 22209
Hooks Johnston(3) ..................................    4,444,312        33.9%     4,444,312        24.5%
Vadim Babenko, Ph.D.(4) ............................    2,479,950        16.0%     2,479,950        12.1%
James Bernstein, M.D.(5) ...........................    2,013,619        13.6%     2,013,619        10.2%
Amersham Pharmacia Biotech, Inc.(6) ................    1,587,747        12.1%     1,587,747         8.8%
 800 Centennial Avenue
 P.O. Box 1327
 Piscataway, NJ 08855-1327
Weiss, Peck & Greer, LLC(7) ........................    1,252,497         9.5%     1,252,497         6.9%
 One New York Plaza
 New York, New York 10004
Paul Capital Partners VI Holdings(8) ...............    1,110,550         8.5%     1,110,550         6.1%
 50 California Street
 Suite 3000
 San Francisco, CA 94111
Timothy Sullivan(9) ................................      916,830         7.0%       916,830         5.1%
Joseph Lehnen(10) ..................................      751,500         5.4%       751,500         4.0%
Harry D'Andrea(11) .................................        5,010           *          5,010          *
Andrew Whiteley ....................................           --          --             --         --
Wei Wu He ..........................................      240,855         1.8%       240,855         1.3%
All directors and executive officers as a group
 (9 persons)(12) ...................................   16,964,276        73.3%    16,964,276        60.3%
</TABLE>



----------
*  Represents less than 1% of the outstanding shares of common stock.


(1)  Includes 4,258,333 shares issuable upon exercise of vested options.


(2)  Includes  2,161,265  shares of our Series A preferred stock to be converted
     into  3,609,312  shares  of common stock upon the closing of this offering.
     The  general  partner  of  FBR  Technology  Venture  Partners II, LP is FBR
     Venture  Capital  Managers, Inc. Mr. Johnston, one of our directors, is the
     Managing Director of FBR Technology Venture Partners II, LP.



                                       64
<PAGE>


(3)  Represents  shares held by FBR Technology Venture Partners II, LP, of which
     Mr. Johnston is the Managing Director.

(4)  Includes 2,396,450 shares issuable upon exercise of vested options.

(5)  Includes  1,696,319  shares  issuable  upon  exercise  of  vested  options,
     417,500  of  which  are  held by family trusts over which Mr. Bernstein has
     voting and dispositive power.

(6)  Includes  950,747  shares  of  our Series B preferred stock to be converted
     into  1,587,747  shares  of common stock upon the closing of this offering.
     Mr.  Whiteley,  one  of  our  directors,  is  a  Vice President of Amersham
     Pharmacia Biotech, Inc.

(7)  Represents  (a)  71,966  shares  held  of record by WPG Networking Overseas
     Master  Fund,  L.P., (b) 343,360 shares held of record by WPG Institutional
     Software  Fund,  L.P.,  (c)  300,902  shares held of record by WPG Raytheon
     Networking  Fund,  L.P.,  (e) 318,211 shares held of record by WPG Raytheon
     Software  Fund,  L.P.,  (f)  170,964  shares held of record by WPG Software
     Fund,  L.P.,  (g)  45,424  shares held of record by WPG Networking QP Fund,
     L.P.,  and  (h) 1,670 shares held of record by Raj Mehra. Messrs. Raj Mehra
     and  Ben Taylor are the general partners of each of the entities identified
     in  (a)  through (g) above and share voting and dispositive power for these
     shares.

(8)  The  general  partner  of  which  Paul  Capital Partners VI is Paul Capital
     Management, Inc. LLC, of which Bryon T. Sheets is the manager.

(9)  Includes 916,830 shares issuable upon exercise of vested stock options.

(10) Includes 751,500 shares issuable upon exercise of vested stock options.

(11) Includes 5,010 shares issuable upon exercise of vested stock options.

(12) Includes  10,026,112 shares issuable upon exercise of vested stock options.



                                       65
<PAGE>

                         DESCRIPTION OF CAPITAL STOCK


     At  the  time of the closing of this offering, our authorized capital stock
will consist of 120 million shares, including:

     o 100  million  shares  of  common  stock,  par  value  $0.001  per  share,
       18,128,514 of which will be outstanding upon completion of this offering;
       and

     o 20 million shares  of preferred stock, par value $0.01 per share, none of
       which will be outstanding upon completion of this offering.

The  following  is  a  summary  of  various  provisions  of our common stock and
preferred  stock.  The  following summary does not purport to be complete and is
subject  to,  and is qualified in its entirety by, the provisions of our amended
and  restated  certificate  of  incorporation  and  amended and restated bylaws,
where such rights are set forth in full, and the provisions of applicable law.


COMMON STOCK


     As  of August 23, 2000, there were 13,128,514 shares of common stock issued
and  outstanding  and held of record by 54 stockholders. An additional 5,197,059
shares  of  our common stock will be issued upon the automatic conversion of all
outstanding  shares  of  our  preferred  stock  on the closing of this offering.
There  will be 18,128,514 shares of common stock outstanding after giving effect
to  the  sale of the shares of common stock offered hereby. See "Shares Eligible
for  Future Sale" for information regarding the number of shares of common stock
underlying outstanding options.


     Voting  Rights.  The  holders  of our common stock are entitled to one vote
per  share  on all matters to be voted on by stockholders. Holders of our common
stock  are  not  entitled  to cumulate their votes in the election of directors.
Generally,  all  matters  on  which stockholders will vote must be approved by a
majority  of the votes entitled to be cast by all shares of common stock present
in  person  or  represented  by  proxy,  subject to any voting rights granted to
holders of any preferred stock.

     Dividends.  Holders  of  our  common stock are entitled to share ratably in
any  dividends  declared  by  our  board  of  directors, subject to any priority
dividend  rights  of  any  preferred stock we may issue in the future. We do not
intend  to  pay  cash  dividends on our common stock for the foreseeable future.
This  is because we intend to retain our cash for working capital and to finance
our  planned  growth.  However,  our  board  of  directors is free to change our
dividend  policy  in  the  future,  based  upon  factors  such as our results of
operations,  financial  condition,  cash flow, cash needs, and future prospects.
If  our  board  of  directors  were to change our dividend policy, so long as we
have  any amount outstanding under our credit facilities with PNC Bank, National
Association,  we would be required to obtain PNC Bank's written consent prior to
the declaration or payment of such dividends.

     Liquidation  Rights.  If we are liquidated, dissolved, or wound up, we must
first  pay  all  amounts  we  owe  our  creditors  and then pay the full amounts
required  to  be  paid  to  holders  of  any  shares of our preferred stock then
outstanding  before  we may make any payments to holders of shares of our common
stock.  All  holders of shares of our common stock are entitled to share ratably
in  any  assets  available  for distribution to them, after all of our creditors
have  been  satisfied and we have paid the liquidation preferences of any of our
preferred stock.

     Other  Rights.  No  shares of our common stock are subject to redemption by
us.  Holders  of shares of our common stock do not have any preemptive rights to
purchase additional shares of our common stock.

     All  of  our  shares  of  our  common  stock  to  be outstanding after this
offering will be validly issued, fully paid and nonassessable.

PREFERRED STOCK


     As  of  August  23,  2000,  there  were  3,112,012 shares of our redeemable
convertible  preferred  stock  authorized,  2,161,265  of  which were designated
Series  A  preferred  stock  and  950,747  of  which  were  designated  Series B
preferred  stock,  each issued and outstanding. Concurrently with the closing of
this  offering,  all  of  our  outstanding  shares  of  preferred  stock will be
converted into shares of our common stock.



                                       66
<PAGE>


     Our  amended and restated certificate of incorporation authorizes our board
of  directors  to  create  and issue preferred stock from time to time in one or
more  classes  or series. In creating and issuing a class or series of preferred
stock,  our  board  of  directors, without further vote of our stockholders, may
determine the exact terms of the class or series, including the following:

     o the  number  of  shares  constituting  the  series  and  the  distinctive
       designation of the series;

     o the dividend rate  on the shares of the series; whether dividends will be
       cumulative,  and if so, from which date or dates, and the relative rights
       of priority, if any, of payment of dividends on shares of the series;

     o whether the series  will  have  voting  rights  in addition to the voting
       rights provided by law, and if so, the terms of the voting rights;

     o whether the series  will have conversion privileges and, if so, the terms
       and conditions of conversion;

     o whether the shares  of  the  series  will  be redeemable, and, if so, the
       dates, terms, and conditions of redemption;

     o whether the series  will  have  a  sinking  fund  for  the  redemption or
       purchase  of shares of that  series,  and, if so, the terms and amount of
       the sinking fund; and

     o the rights of  the  shares of the series in the event of our voluntary or
       involuntary  liquidation,  dissolution,  or winding  up and the  relative
       rights or priority, if any, of payment of shares of the series.


REGISTRATION RIGHTS

     FBR  Technology  Venture  Partners II, LP, Amersham Pharmacia Biotech, each
of  the  Weiss,  Peck & Greer entities disclosed in the "Principal Stockholders"
table,  Paul  Capital  Partners  VI Holdings, PNC Bank, National Association and
four  accredited  investors have certain registration rights as to the 8,241,276
shares  of  common  stock or warrants to acquire common stock they will own upon
the  closing  of  this  offering. FBR is entitled to certain demand registration
rights  pursuant  to  which  it  may require us to file a registration statement
under  the  Securities  Act  with  respect  to  their  shares  of  common stock.
Beginning  on  the  date  180  days  from  the effectiveness of our registration
statement  in  connection  with  this  offering,  FBR  may,  subject  to certain
conditions,  require  us  to  use  our  best  efforts  to  effect a registration
statement  on  their behalf on not more than two occasions. In the event that we
are  able  to register our shares through use of a short-form registration under
the  Securities  Act,  FBR,  Amersham,  WPG,  Paul  Capital  and  the accredited
investors  may,  subject  to  certain  conditions require that we register their
shares  on  such form, provided that we have not filed a short form registration
within  12  months  of the date of the demand. FBR is permitted up to four short
form  registration  demands,  while  WPG,  Paul  Capital and the four accredited
investors  together  are  permitted  up  to two short form registration demands.
Amersham  does  not  have  a  similar  limit  with  regard  to  its  short  form
registration rights.

     In  the  event  that  we propose to register any of our securities for sale
under  the  Securities Act, except for certain employee benefit plans or as part
of  certain  corporate  reorganizations,  each  of  the  stockholders  above are
entitled  to notice of such registration and to "piggyback" onto and include its
shares   in   that  registration.  These  registration  rights  are  subject  to
conditions  and  limitations,  including  the right of our underwriters to limit
the  number  of  shares  included  in  such  offering  and  our  right  to delay
registration   because   it  would  be  seriously  detrimental  to  us  and  our
stockholders.  All registration rights above terminate not later than five years
from  the  date of effectiveness of our registration statement in this offering,
except   for   FBR   and   Amersham's  respective  "piggyback"  and  short  form
registration  rights which terminate when all shares held by the investor can be
sold  under  Rule  144  in  any  90  day period, or in the case of FBR, if FBR's
ownership  of  our  stock  falls below 1% of our then outstanding shares. We are
generally  responsible  for the costs and expenses of all such registrations. We
are  required  to  obtain  the  consent  of the holders of two-thirds of FBR and
Amersham's  shares prior to the granting of equal or more favorable registration
rights to any third party.



                                       67
<PAGE>

SHAREHOLDERS' AGREEMENT


     We  are  party  to  a  shareholders'  agreement  with  Drs.  Titomirov  and
Bernstein,  the  "Founders,"  certain  individual shareholders who together with
the  Founders  are  referred  to  as  the  "Individual Parties", and each of the
Weiss,  Peck  &  Greer entities noted in the Principal Stockholder table. Unless
terminated  in  writing,  the agreement continues in effect until the earlier of
the  date  on  which  all our common stock is owned by one of the parties to the
agreement  or  such  date  on  which  more than 50% of our outstanding shares of
common  stock  are  registered  under the Securities Act. The agreement provides
that  so  long as the Founders continue to hold shares of common stock, have not
departed  from  InforMax  and  are  able  to perform services for InforMax of at
least  15  eight-hour  days  during any six month period, the Individual Parties
will  vote  all  of  their  shares to elect each of the Founders to our board of
directors.   The   shareholders'  agreement  contains  certain  restrictions  on
transfer  that  limit the ability of the parties to sell, transfer, or otherwise
dispose  of  their  shares. The agreement provides that upon any separation from
InforMax  of an Individual Party, we and the remaining Individual Parties have a
six-month  option  to  purchase  all,  but  not  less  than all of the separated
party's  shares.  A  separation from InforMax includes, for example, disability,
death,  resignation  or  termination  other  than for cause. If we terminate the
employment  of  any  Founder  for cause, we and the remaining Individual Parties
will  have a six month option to purchase any or all of the terminated Founder's
shares.  The  Individual  Parties may not sell, transfer or otherwise dispose of
their  shares  to a third party without giving the other parties notice of their
intent  to sell, and a right of first refusal to purchase all, but not less than
all,  of  such  shares  on  the same terms. Transfer of shares to third persons,
including  family  members,  is permitted, provided such persons become bound by
the  terms  of the agreement. During the term of the agreement, and for a period
of  two  years  after its termination, the Individual Parties have agreed not to
compete,  directly  or  indirectly,  with us in the development and licensing of
our  bioinformatic software. In connection with a private sale transaction, Paul
Capital   was   assigned   certain   rights  and  assumed  all  obligations  and
responsibilities  as  a shareholder party under the shareholders' agreement with
regard to its shares of common stock purchased from Dr. Titomirov.

DIRECTORS' LIABILITIES

     As  permitted  by  the  Delaware  General  Corporation Law, as amended, the
"DGCL,"  our  certificate of incorporation limits the liability of our directors
to  our company or our stockholders for monetary damages for breach of fiduciary
duty  as  directors to the fullest extent permitted by the DGCL as it now exists
or  as  it  may  be amended. As of the date of this prospectus, the DGCL permits
limitations  of  liability  for  director's  breach of fiduciary duty other than
liability:

     o for  any  breach  of the director's duty of loyalty to our company or our
stockholders,

     o for acts or  omissions  not  in  good  faith  or that involve intentional
       misconduct or a knowing violation of law,

     o under Section 174 of the DGCL, or

     o for  any transaction from which the director derived an improper personal
       benefit.

In  addition,  our  bylaws provide that we will indemnify, to the fullest extent
permitted  under  the DGCL, all of our directors, officers, employees and agents
for acts performed on our behalf in such capacity.


ANTI-TAKEOVER PROVISIONS OF CHARTER DOCUMENTS AND DELAWARE LAW


     We  are  subject  to the provisions of Section 203 of the DGCL. In general,
the  statute  prohibits  a publicly held Delaware corporation from engaging in a
"business  combination"  with  an "interested stockholder" for a period of three
years  after  the  date that the person became an interested stockholder unless,
with  some  exceptions, the business combination or the transaction in which the
person  became  an  interested  stockholder  is approved in a prescribed manner.
Generally,  a  "business  combination" includes a merger, asset or stock sale or
other  transaction  resulting  in a financial benefit to the stockholder, and an
"interested   stockholder"  is  a  person  who,  together  with  affiliates  and
associates,  owns,  or  within  three  years  prior, did own, 15% or more of the
corporation's outstanding voting stock.



                                       68
<PAGE>


     Upon  completion  of this offering, our charter documents also will contain
provisions  that  may  have  the  effect  of  delaying  or preventing changes in
control  or  management  of  InforMax, which could have an adverse effect on the
market  price  of  our  common  stock.  For  example, our charter documents will
contain  a  provision eliminating the ability of stockholders to take actions by
written   consent.   In  addition,  our  amended  and  restated  certificate  of
incorporation  to  be  effective  upon completion of this offering also provides
that  the  board  of  directors will be divided into three classes, each serving
staggered three-year terms, following the completion of this offering:

   o Class  I,  whose initial term will expire at the annual meeting, or special
     meeting held in lieu of an annual meeting, of stockholders held in 2001;

   o Class  II,  whose  initial  term  will  expire  at  the  annual meeting, or
     special  meeting held in lieu of an annual meeting, of stockholders held in
     2002; and

   o Class  III,  whose  initial  term  will  expire  at  the annual meeting, or
     special  meeting held in lieu of an annual meeting, of stockholders held in
     2003.

As  a result, only one class of directors will be elected at each annual meeting
of  stockholders  of  InforMax,  with  the  other  classes  continuing  for  the
remainder of their respective terms.

     Our  amended and restated certificate of incorporation permits our board of
directors  to  issue up  to  20 million shares of preferred stock and to fix the
rights,  preferences,  privileges  and restrictions, including voting rights, of
these  shares  without  any further vote or action by the stockholders. Issuance
of  our  preferred  stock  could  have  the  effect  of  delaying,  deferring or
preventing  a  change  in  control,  as  removal  of  our board of directors and
management  may  be rendered more difficult. Issuance of our preferred stock may
have  a  negative  impact  on the ability of our stockholders to participate, if
applicable,  in  a  tender  offer  or exchange offer for the common stock, which
would diminish the value of our common stock.

     Further,  our issuance of preferred stock also could decrease the amount of
any  earnings  and  assets  available  for distribution to the holders of common
stock  or  could  negatively  affect  the  rights  and  powers, including voting
rights, of the holders of the common stock.

     Our  bylaws  will  not permit our stockholders to call a special meeting of
stockholders.  Under  the  bylaws,  only our President, Chairman of the board of
directors,  or  a  majority  of  the  board  of directors will be able to call a
special  meeting.  The bylaws also require that stockholders give advance notice
to  our  secretary  of  any  nominations  for  director  or other business to be
brought  by  stockholders  at  any  stockholders'  meeting. These provisions may
delay or prevent changes of control or management.



TRANSFER AGENT


     The  transfer  agent  and  registrar for our common stock is American Stock
Transfer & Trust Company.



                                       69
<PAGE>

                        SHARES ELIGIBLE FOR FUTURE SALE


     Before  this  offering,  there  has  been  no  public market for our common
stock.  Future  sales  of  substantial  amounts of our common stock, or even the
possibility  of  future  sales,  could reduce the prevailing market price of our
common  stock.  As  described  below,  only a limited number of shares of common
stock  currently  held  by  our  stockholders will be available for sale shortly
after  this  offering  because  of contractual and legal restrictions on resale.
Sales  of  substantial  amounts  of  common stock in the public market after the
restrictions  lapse  could negatively affect the prevailing market price and our
ability to raise equity capital in the future.

     Upon  the  closing  of this offering, 18,128,514 shares of our common stock
will  be  outstanding  based  on the number of shares of our preferred stock and
common  stock outstanding as of August 23, 2000, and assuming no exercise of the
underwriters'  over-allotment  option.  Of these shares, the 5,000,000 shares of
common  stock  being  sold  in  this  offering  will  be freely tradable without
restriction  under  the  Securities  Act,  unless purchased by an "affiliate" of
ours  as  such  term  is defined in the Securities Act. The remaining 13,128,514
shares  of  common  stock were issued and sold by us in private transactions and
are   "restricted  securities"  that  are  eligible  for  public  sale  only  if
registered  under  the  Securities Act or sold in compliance with Rule 144 under
that Act.

     All  of our officers, directors, and holders of at least ___________ shares
of  our  stock  have  signed  lock-up agreements, in which they agreed that they
will  not,  directly  or indirectly, offer, sell, or agree to sell, or otherwise
dispose  of any shares of our common stock or other securities without the prior
written  consent  of Bear, Stearns & Co. Inc., for a period of 180 days from the
date  of  this  prospectus.  The  lock-up  agreements do not apply to any shares
acquired in this offering through the directed share program.

     Rule  144. In general, under Rule 144 of the Securities Act as currently in
effect,  beginning  90  days  after  the  date  of  this prospectus, a person or
persons  whose  shares  are  aggregated,  who  has beneficially owned restricted
securities  for  at  least one year, including the holding period of any earlier
owner  except  an  affiliate,  will  be  entitled to sell within any three month
period a number of shares that do not exceed the greater of:

     o 1% of the  number  of  shares of our common stock then outstanding, which
       will equal approximately  181,285 shares immediately after this offering;
       or

     o the average weekly  trading  volume  of  our  common  stock on the Nasdaq
       National  Market  during the four  calendar  weeks before the filing of a
       notice on Form 144 with respect to the sale.


Sales  under  Rule  144 are also subject to manner of sale provisions and notice
requirements and to the availability of current public information about us.


     Rule  144(k).  Under  Rule  144(k)  of  the  Securities Act as currently in
effect,  a  person  who  is  not one of our affiliates at any time during the 90
days  before  a  sale,  and who has beneficially owned the shares proposed to be
sold  for  at least two years, including the holding period of any earlier owner
except  an  affiliate,  is  entitled to sell these shares without complying with
the  manner of sale, public information, volume limitation, or notice provisions
of Rule 144.

     Registration  Rights.  As  described  above, holders of 8,241,276 shares of
our  common  stock,  or  warrants  to  acquire common stock, that are restricted
securities  will  be  entitled  to  certain  registration  rights covering their
shares.  Registration  of  their shares under the Securities Act would result in
these  shares  becoming freely tradable without restriction under the Securities
Act  immediately  upon the effectiveness of that registration, except for shares
purchased by affiliates.


     Rule  701. In general, under Rule 701 of the Securities Act as currently in
effect,  any  of our employees, consultants, or advisors, other than affiliates,
who  purchases  or  receives  shares  from  us  in  connection  with  our equity
incentive  plan  or  other  written  agreement  will be eligible to resell their
shares  beginning 90 days after the date of this prospectus, subject only to the
manner  of  sale  provisions  of  Rule 144. Affiliates will be able to sell such
shares under Rule 144 without compliance with its holding period requirements.


                                       70
<PAGE>

     Stock  Options.  Following  this  offering we intend to file a registration
statement  on  Form  S-8  under the Securities Act covering the shares of common
stock  underlying  options  held  by  our  officers,  directors  and  employees,
including  shares  reserved for issuance under our equity incentive compensation
plan.  The  registration statement on Form S-8 will become effective upon filing
with  the  Securities  and  Exchange  Commission. Accordingly, shares registered
under  that  registration  statement  will, subject to limitations applicable to
affiliates,  be  available  for sale in the open market after the filing, except
those shares subject to lock-up agreements and unvested shares.


                                       71
<PAGE>

                                 UNDERWRITING

     Subject  to  the  terms  and  conditions provided in an agreement among the
underwriters   and   us,   the   underwriters   named   below,   through   their
representatives  Bear,  Stearns  & Co. Inc., U.S. Bancorp Piper Jaffray Inc. and
Adams,  Harkness  &  Hill,  Inc.,  have severally agreed to purchase from us the
aggregate  number  of  shares of our common stock indicated opposite their names
below:





<TABLE>
<CAPTION>
                                                       NUMBER
UNDERWRITER                                           OF SHARES
--------------------------------------------------   ----------
<S>                                                  <C>
         Bear, Stearns & Co. Inc. ................
         U.S. Bancorp Piper Jaffray Inc. .........
         Adams, Harkness & Hill, Inc. ............


         Total ...................................

</TABLE>


     The  underwriting  agreement  provides  that the obligations of the several
underwriters  are  subject to approval of various legal matters by their counsel
and  to  various  other  conditions, including delivery of legal opinions by our
counsel,  the  delivery of a letter by our independent auditors and the accuracy
of  the representations and warranties made by us in the underwriting agreement.
Under  the  underwriting agreement, the underwriters are obliged to purchase and
pay for all the above shares of our common stock if any are purchased.



PUBLIC OFFERING PRICE

     The  underwriters  propose to offer the shares of our common stock directly
to  the  public  at  the  offering  price  indicated  on  the cover page of this
prospectus  and  at  that  price less a concession not in excess of $ ______ per
share  of  common  stock  to  other  dealers  who  are  members  of the National
Association  of  Securities  Dealers, Inc. The underwriters may allow, and those
dealers  may  reallow,  concessions not in excess of $______ per share of common
stock  to  other  underwriters  or  to  other  dealers. After this offering, the
offering  price,  concessions  and  other  selling  terms  may be changed by the
underwriters.  Our  common stock is offered subject to receipt and acceptance by
the  underwriters and subject to other conditions, including the right to reject
orders  in  whole  or  in  part.  The  underwriters  have  informed  us that the
underwriters  do  not  expect  to  confirm sales of common stock to any accounts
over which they exercise discretionary authority.


     The  following  table  summarizes  the  per share and total public offering
price  of  the  shares  of  common  stock  in  the  offering,  the  underwriting
compensation  to  be  paid  to  the  underwriters by us, and the proceeds of the
offering,  before  expenses,  to us. The information presented assumes either no
exercise or full exercise by the underwriters of their over-allotment option.






<TABLE>
<CAPTION>
                                                                               TOTAL
                                                                  --------------------------------
                                                                       WITHOUT           WITH
                                                       PER SHARE   OVER-ALLOTMENT   OVER-ALLOTMENT
                                                      ----------- ---------------- ---------------
<S>                                                   <C>         <C>              <C>
Public offering price ...............................    $             $                $
Underwriting discounts and commissions payable by us
Proceeds, before expenses, to us ....................
</TABLE>

     The  underwriting  discount and commission per share is equal to the public
offering  price  per  share  of  our  common  stock  less the amount paid by the
underwriters to us per share of common stock.


     We  estimate total expenses payable by us in connection with this offering,
other  than  the  underwriting discounts and commissions referred to above, will
be approximately $ 1,200,000.



                                       72
<PAGE>


OVER-ALLOTMENT OPTION TO PURCHASE ADDITIONAL SHARES


     We  have  granted  a  30-day  over-allotment  option to the underwriters to
purchase  up  to  an  aggregate of 750,000 additional shares of our common stock
exercisable   at   the  offering  price  less  the  underwriting  discounts  and
commissions,  each  as  provided  on  the  cover page of this prospectus. If the
underwriters  exercise  this  option  in  whole  or  in  part,  then each of the
underwriters  will be obligated to purchase additional shares of common stock in
proportion  to  their  respective purchase commitments as shown in the table set
forth above, subject to various conditions.



INDEMNIFICATION AND CONTRIBUTION



     The   underwriting   agreement   provides   that   we  will  indemnify  the
underwriters  against  liabilities specified in the underwriting agreement under
the  Securities  Act,  including liabilities arising from material misstatements
or  omissions in connection with disclosure, or will contribute to payments that
the  underwriters  may  be required to make in respect of those liabilities. The
underwriters  have  agreed  to indemnify us against liabilities specified in the
underwriting  agreement under the Securities Act. Insofar as indemnification for
liabilities   arising   under  the  Securities  Act  may  be  permitted  to  the
underwriters,  the  underwriters  have  been advised that, in the opinion of the
Securities  and  Exchange  Commission,  such  indemnification  is against public
policy as expressed in the Securities Act and is, therefore, unenforceable.



LOCK-UP AGREEMENTS



     Our  directors  and  officers and our stockholders holding _________ shares
of  our  stock  have  agreed  that they will not, directly or indirectly, offer,
sell  or  agree  to sell, or otherwise dispose of any shares of our common stock
or  convertible  securities without the prior written consent of Bear, Stearns &
Co. Inc. for a period of 180 days from the date of this prospectus.


     In  addition, we have agreed that for a period of 180 days from the date of
this  prospectus,  we  will  not,  without  the  prior  written consent of Bear,
Stearns & Co. Inc., directly or indirectly:


     o issue, offer, sell,  grant any option, warrant or other right to purchase
       or  otherwise  dispose  of any  shares  of  common  stock or  convertible
       securities,

     o pledge, make any  short sale or maintain any short position, establish or
       maintain a put position,

     o enter into any  swap,  derivative  transaction  or other arrangement that
       transfers  to another any of the  economic  consequences  of ownership of
       common stock, or

     o otherwise dispose of  any  common  stock or convertible securities or any
       interest in our common stock or convertible securities.



NASDAQ NATIONAL MARKET QUOTATION


     Before  this  offering,  there  has  been  no  public market for our common
stock.  As a result, the initial public offering price for the common stock will
be  determined  by  negotiations  between  us  and  the  representatives  of the
underwriters.  Among  the  factors  to  be considered in determining the initial
public  offering  price will be our future prospects and the future prospects of
our  industry  in  general,  our sales, earnings and certain other financial and
operating   information  in  recent  periods,  and  the  price-earnings  ratios,
price-sales  ratios,  market  prices  of  securities  and  certain financial and
operating  information  of  companies  engaged in activities similar to ours. We
have  applied  for  approval for the quotation of our common stock on the Nasdaq
National  Market,  under  the symbol "INMX." We cannot assure you, however, that
an  active  or  orderly trading market will develop for our common stock or that
the  common stock will trade in the public market subsequent to this offering at
or above the initial offering price.


                                       73
<PAGE>


STABILIZATION, SYNDICATE SHORT POSITION AND PENALTY BIDS

     In  order  to facilitate the offering of our common stock, the underwriters
may  engage  in  transactions  that stabilize, maintain, or otherwise affect the
market price of our common stock.

     The  underwriters  may  over-allot shares of our common stock in connection
with  this offering, thus creating a short position for their own account. Short
sales  involve  the  sale by the underwriters of a greater number of shares than
they  are  committed  to  purchase in the offering. A short position may involve
either  "covered"  short  sales  or "naked" short sales. Covered short sales are
sales  made  in  an  amount  not  greater  than the underwriters' over-allotment
option  to  purchase  additional  shares  in  the  offering described above. The
underwriters  may  close  out  any  covered  short position by either exercising
their  over-allotment  option  or  purchasing  shares  in  the  open  market. In
determining  the  source  of  shares  to  close  the covered short position, the
underwriters  will  consider,  among other things, the price of shares available
for  purchase  in  the  open  market  as compared to the price at which they may
purchase  shares  through the over-allotment option. Naked short sales are sales
in  excess  of  the  over-allotment  option. The underwriters must close out any
naked  short  position  by  purchasing  shares in the open market. A naked short
position  is  more  likely  to be created if the underwriters are concerned that
there  may  be  downward  pressure on the price of the shares in the open market
after  pricing  that  could  adversely  affect  investors  who  purchase  in the
offering.

     Accordingly,  to  cover  these  short  sales  positions or to stabilize the
market  price  of  our common stock, the underwriters may bid for, and purchase,
shares  of  our  common  stock  in  the  open  market. These transactions may be
effected   on  the  Nasdaq  National  Market  or  otherwise.  Additionally,  the
representatives,  on  behalf  of  the  underwriters,  may  also  reclaim selling
concessions  allowed  to  an  underwriter  or  dealer. Similar to other purchase
transactions,  the underwriters' purchases to cover the syndicate short sales or
to  stabilize  the  market  price  of  our  common  stock may have the effect of
raising  or  maintaining  the  market price of our common stock or preventing or
mitigating  a  decline in the market price of our common stock. As a result, the
price  of  shares  of  our  common stock may be higher than the price that might
otherwise  exist  in  the  open  market.  No  representation  is  made as to the
magnitude  or  effect  of  any  such  stabilization  or  other  activities.  The
underwriters  are  not required to engage in these activities and, if commenced,
may end any of these activities at any time.



DIRECTED SHARE PROGRAM

     At  our  request,  the  underwriters  have reserved for sale at the initial
public  offering  price  up to _______ shares of common stock to be sold in this
offering  for  sale  to our directors, officers, employees, business associates,
vendors  and  related  persons.  Purchases  of  reserved  shares  are to be made
through  an account at Bear, Stearns & Co. Inc. in accordance with Bear, Stearns
&  Co.  Inc.'s  procedures for opening an account and transacting in securities.
The  number  of  shares available for sale to the general public will be reduced
to  the  extent  that any reserved shares are purchased. Any reserved shares not
purchased  by  our  directors, officers, employees, business associates, vendors
and  related  persons  will be offered by the underwriters to the general public
on the same terms as the other shares offered by this prospectus.


                                       74
<PAGE>

                                 LEGAL MATTERS

     Certain  legal  matters,  including  the  legal  validity  of the shares of
common  stock  we are offering, will be passed upon for us by our counsel, Hogan
&  Hartson  L.L.P.,  Washington,  D.C.  Certain legal matters in connection with
this  offering will be passed upon for the underwriters by Coudert Brothers, New
York,  New  York.  A  partner of Hogan & Hartson L.L.P. beneficially owns 33,748
shares of our common stock.


                                    EXPERTS

     The  consolidated financial statements as of December 31, 1998 and 1999 and
for  each  of  the three years in the period ended December 31, 1999 included in
this  prospectus  have  been  audited  by  Deloitte  &  Touche, LLP, independent
auditors,  as  stated  in  their  reports  appearing  herein,  and  have been so
included  in  reliance  upon the report of such firm  given upon their authority
as experts in accounting and auditing.


                            ADDITIONAL INFORMATION


     We  have filed a registration statement on Form S-1 with the Securities and
Exchange  Commission  under the Securities Act covering the shares of our common
stock  offered  by  this prospectus. The registration statement contains certain
exhibits  and  schedules  described  in  this  prospectus.  Where  contracts  or
documents  are  filed  as  exhibits,  descriptions  in  this  prospectus of such
contracts  or  other documents are qualified in all respects by the exhibit. For
further  information about us and the shares we are offering by this prospectus,
you  should  review  this  registration statement and the exhibits and schedules
attached  to  it.  A  copy of our registration statement, including the exhibits
and   schedules,  may  be  read  and  copied  at  the  Securities  and  Exchange
Commission's  Public  Reference Room at 450 Fifth Street, N.W., Washington, D.C.
20549.  Information  on  the  operation  of  the  Public  Reference  Room may be
obtained  by  calling  the Securities and Exchange Commission at 1-800-SEC-0330.
Also,  the  Securities  and  Exchange  Commission  maintains an Internet site at
http://www.sec.gov,  from  which  you can electronically access our registration
statement, including the exhibits and schedules attached to it.


     As  a  result  of  this  offering,  we  will  become  subject  to  the full
informational  requirements of the Securities Exchange Act of 1934. We intend to
fulfill  these  requirements  by  filing  periodic reports and other information
with   the  Securities  and  Exchange  Commission.  We  intend  to  furnish  our
stockholders  with  annual  reports containing consolidated financial statements
certified by an independent public accounting firm.


                                       75
<PAGE>

                  INDEX TO CONSOLIDATED FINANCIAL STATEMENTS




<TABLE>
<CAPTION>
                                                                                           PAGE
                                                                                          -----
<S>                                                                                       <C>
Independent Auditors' Report ............................................................ F-2
Consolidated Balance Sheets as of December 31, 1998 and 1999 and as of
 June 30, 2000 -- actual and proforma, (unaudited) ...................................... F-3
Consolidated Statements of Operations for the years ended December 31, 1997, 1998
 and 1999 and for the six months ended June 30, 1999 and 2000 (unaudited) ............... F-5
Consolidated Statements of Changes in Stockholders' Equity (Deficit) for the years ended
 December 31, 1997, 1998 and 1999 and for the six months ended June 30, 2000 (unaudited)  F-6
Consolidated Statements of Cash Flows for the years ended December 31, 1997, 1998
 and 1999 and for the six months ended June 30, 1999 and 2000 (unaudited) ............... F-7
Notes to Consolidated Financial Statements .............................................. F-10
</TABLE>


                                      F-1
<PAGE>


     THE  ACCOMPANYING  CONSOLIDATED  FINANCIAL  STATEMENTS  GIVE  EFFECT TO THE
COMPLETION OF THE  1.67-FOR-1  SPLIT OF COMMON  STOCK,  CHANGE IN PAR VALUE FROM
$0.01 TO  $0.001,  AN  INCREASE  IN THE  AUTHORIZED  SHARES OF  COMMON  STOCK TO
100,000,000,  AND THE AUTHORIZATION OF 20,000,000 SHARES OF PREFERRED STOCK WITH
A PAR VALUE OF $0.01 WHICH WILL TAKE PLACE AFTER APPROVAL BY THE COMPANY'S BOARD
AND PRIOR TO THE EFFECTIVE  DATE OF THE  REGISTRATION  STATEMENT.  THE FOLLOWING
REPORT IS IN THE FORM  WHICH  WILL BE  FURNISHED  BY  DELOITTE & TOUCHE LLP UPON
COMPLETION OF THE STOCK SPLIT,  CHANGE IN PAR VALUE, AND AUTHORIZATION OF COMMON
AND  PREFERRED  STOCK  DESCRIBED  IN  NOTE  16  TO  THE  CONSOLIDATED  FINANCIAL
STATEMENTS  AND  ASSUMING  THAT  FROM  DECEMBER  31,  1999  TO THE  DATE OF SUCH
COMPLETION  NO OTHER  MATERIAL  EVENTS  HAVE  OCCURRED  THAT  WOULD  AFFECT  THE
ACCOMPANYING CONSOLIDATED FINANCIAL STATEMENTS OR REQUIRED DISCLOSURE THEREIN.


Deloitte & Touche LLP

McLean, Virginia
August 31, 2000



                         INDEPENDENT AUDITORS' REPORT



To the Board of Directors of
InforMax, Inc. and Subsidiary
Rockville, Maryland

We  have  audited the accompanying consolidated balance sheets of InforMax, Inc.
and  subsidiary  as  of December 31, 1998 and 1999, and the related consolidated
statements  of  operations,  changes in stockholders' equity (deficit), and cash
flows  for  each of the three years in the period ended December 31, 1999. These
financial  statements  are  the  responsibility of the Company's management. Our
responsibility  is  to  express  an opinion on the financial statements based on
our audits.


We  conducted  our  audits  in  accordance  with  auditing  standards  generally
accepted  in  the United States of America. Those standards require that we plan
and  perform  the  audit  to  obtain  reasonable  assurance  about  whether  the
financial  statements  are  free  of  material  misstatement.  An audit includes
examining,  on  a test basis, evidence supporting the amounts and disclosures in
the  financial  statements.  An  audit  also  includes  assessing the accounting
principles  used  and  significant  estimates  made  by  management,  as well as
evaluating  the  overall  financial  statement presentation. We believe that our
audits provide a reasonable basis for our opinion.


In  our  opinion,  such consolidated financial statements present fairly, in all
material  respects,  the  financial position of InforMax, Inc. and subsidiary as
of  December  31,  1998  and 1999, and the results of their operations and their
cash  flows  for  each of the three years in the period ended December 31, 1999,
in  conformity  with  accounting  principles  generally  accepted  in the United
States of America.



McLean, Virginia
June  7,  2000,  except  for  Note  16, paragraphs six, seven, eight, nine, ten,
eleven,  and twelve as to which the dates are June 19, 2000, June 23, 2000, June
29,  2000,  June  30,  2000,  July  7,  2000, August 16, 2000, and       , 2000,
respectively.



                                      F-2
<PAGE>

                                INFORMAX, INC.

                          CONSOLIDATED BALANCE SHEETS






<TABLE>
<CAPTION>
                                                       DECEMBER 31,                     JUNE 30, 2000
                                               -----------------------------   --------------------------------
                                                                                                   (PRO FORMA)
                                                    1998            1999            ACTUAL          (NOTE 2)
                   ASSETS                      -------------   -------------   ---------------   --------------
                                                                                 (UNAUDITED)       (UNAUDITED)
<S>                                            <C>             <C>             <C>               <C>
Current assets:
 Cash and cash equivalents .................    $  295,669      $1,398,937       $ 2,090,541      $12,090,541
 Accounts receivable (net of allowance for
   doubtful accounts of $15,000 at December
   31, 1998 and 1999 and $20,000 at June 30,
   2000 (unaudited)), respectively .........     1,550,328       2,640,485         3,666,023        3,666,023
 Income tax receivable .....................             -         122,446                 -                -
 Deferred tax asset ........................       581,353         676,379            52,872           52,872
 Prepaid expenses ..........................             -         222,473           192,157          192,157
 Deferred offering costs ...................             -               -           373,740          373,740
 Other current assets ......................         9,435          28,837            35,731           35,731
                                                ----------      ----------       -----------      -----------
    Total current assets ...................     2,436,785       5,089,557         6,411,064       16,411,064
                                                ----------      ----------       -----------      -----------
Property and equipment:
 Computer equipment ........................       434,669       1,060,435         1,684,488        1,684,488
 Purchased software ........................         4,340          58,306           118,822          118,822
 Office furniture and equipment ............        46,236         537,908         1,063,212        1,063,212
 Leasehold improvements ....................             -         155,122           243,316          243,316
                                                ----------      ----------       -----------      -----------
                                                   485,245       1,811,771         3,109,838        3,109,838
 Less: Accumulated depreciation and
   amortization ............................      (114,426)       (375,472)         (717,989)        (717,989)
                                                ----------      ----------       -----------      -----------
    Property and equipment - net ...........       370,819       1,436,299         2,391,849        2,391,849
                                                ----------      ----------       -----------      -----------
Other assets:
 Deposits ..................................        10,883          67,996            81,519           81,519
 Loan to shareholder .......................             -          69,360                 -                -
 Deferred tax asset ........................        64,341         601,500         1,225,007        1,225,007
                                                ----------      ----------       -----------      -----------
    Total other assets .....................        75,224         738,856         1,306,526        1,306,526
                                                ----------      ----------       -----------      -----------
Total assets ...............................    $2,882,828      $7,264,712       $10,109,439      $20,109,439
                                                ==========      ==========       ===========      ===========
</TABLE>


                See notes to consolidated financial statements.

                                      F-3
<PAGE>

                                INFORMAX, INC.

                          CONSOLIDATED BALANCE SHEETS






<TABLE>
<CAPTION>
                                                                       DECEMBER 31,                   JUNE 30, 2000
                                                               ----------------------------- -------------------------------
                                                                                                                PRO FORMA
                                                                    1998           1999           ACTUAL         (NOTE 2)
LIABILITIES AND STOCKHOLDERS' EQUITY (DEFICIT)                 ------------- --------------- --------------- ---------------
                                                                                               (UNAUDITED)     (UNAUDITED)
<S>                                                            <C>           <C>             <C>             <C>
Accounts payable .............................................  $  391,477    $    404,016    $  1,145,226    $  1,145,226
 Accounts payable to related parties .........................      23,325          21,806         352,847         352,847
 Accrued liabilities .........................................     341,972         933,125         484,488         484,488
 Line of credit ..............................................     200,000         550,000       1,650,000       1,650,000
 Equipment loan facility - current portion ...................           -         337,302         664,000         664,000
 Notes payable ...............................................      64,415               -               -               -
 Capital lease obligations - current portion .................     114,106         113,293          96,815          96,815
 Deferred revenue ............................................   1,489,389       1,689,997       3,301,025       3,301,025
 Income taxes payable ........................................     151,296               -               -               -
 Billings in excess of cost on government contracts ..........      79,796               -               -               -
                                                                ----------    ------------    ------------    ------------
    Total current liabilities ................................   2,855,776       4,049,539       7,694,401       7,694,401
                                                                ----------    ------------    ------------    ------------
Long-term liabilities:
 Capital lease obligations - less current portion ............     182,346          92,208          48,873          48,873
 Equipment loan facility - less current portion ..............           -         623,245       1,241,973       1,241,973
 Deferred revenue ............................................     249,886         121,673         309,704         309,704
                                                                ----------    ------------    ------------    ------------
    Total long-term liabilities ..............................     432,232         837,126       1,600,550       1,600,550
                                                                ----------    ------------    ------------    ------------
Commitments and contingencies
 (Notes 13 and 14 ) ..........................................
Series A redeemable convertible preferred stock, par value
 $0.01; no shares authorized, issued and outstanding at
 December 31, 1998, 2,161,265 shares authorized, issued,
 and outstanding at December 31, 1999 and June 30,
 2000 (unaudited) and no shares issued and outstanding
 at June 30, 2000 pro forma (unaudited), liquidation
 preference - $1.85 per share.................................           -       4,095,054       4,263,194               -
                                                                ----------    ------------    ------------    ------------
Series B redeemable convertible preferred stock, par value
 $0.01--950,747 shares authorized, and no shares issued
 and outstanding at June 30, 2000, pro forma
 (unaudited) .................................................           -               -               -               -
                                                                ----------    ------------    ------------    ------------
Stockholders' equity (deficit):
 Common stock - voting, par value $0.001; 100,000,000
   shares authorized; 1,914,822, 2,505,000, 2,254,500, and
   12,983,068 shares issued, and 1,664,322, 2,254,500,
   2,254,500, and 12,983,086 shares outstanding at
   December 31, 1998 and 1999, June 30, 2000
   (unaudited), and June 30, 2000 pro forma
   (unaudited), respectively .................................       1,915           2,505           2,255          12,983
 Common stock - nonvoting, par value $0.001; 14,931,864
   shares authorized; 2,387,098, 2,034,060, 5,531,508 and
   no shares issued, and 2,069,798, 1,716,760, 5,531,508,
   and no shares outstanding at December 31, 1998 and
   1999, June 30, 2000 (unaudited) and June 30, 2000 pro
   forma (unaudited), respectively ...........................       2,387           2,034           5,531               -
 Subscription receivable .....................................           -               -      (1,013,436)     (1,013,436)
 Additional paid-in capital ..................................     583,865         970,806       6,260,877      20,518,874
 Deferred compensation .......................................     (16,218)       (400,208)       (461,734)       (461,734)
 Accumulated deficit .........................................    (858,129)     (2,173,144)     (8,242,199)     (8,242,199)
 Treasury stock, 567,800 shares at cost at December 31,
   1998 and 1999 and no shares at June 30, 2000
   (unaudited) and June 30, 2000 pro forma (unaudited),
   respectively ..............................................    (119,000)       (119,000)              -               -
                                                                ----------    ------------    ------------    ------------
    Total stockholders' equity (deficit) .....................    (405,180)     (1,717,007)     (3,448,706)     10,814,488
                                                                ----------    ------------    ------------    ------------
Total liabilities and stockholders' equity (deficit) .........  $2,882,828    $  7,264,712    $ 10,109,439    $ 20,109,439
                                                                ==========    ============    ============    ============
</TABLE>


                See notes to consolidated financial statements.

                                      F-4
<PAGE>

                                INFORMAX, INC.

                     CONSOLIDATED STATEMENTS OF OPERATIONS






<TABLE>
<CAPTION>
                                                                                                      SIX MONTHS ENDED
                                                             YEAR ENDED DECEMBER 31,                      JUNE 30,
                                                   ------------------------------------------- -------------------------------
                                                        1997          1998           1999            1999            2000
                                                   ------------- ------------- --------------- --------------- ---------------
                                                                                                 (UNAUDITED)     (UNAUDITED)
<S>                                                <C>           <C>           <C>             <C>             <C>
Revenues:
 Software license and customer support ...........  $1,334,510    $2,732,382    $  7,277,627     $ 3,321,877    $  4,854,534
 Professional services ...........................     867,212     1,393,863       2,736,798       1,159,250       1,655,395
                                                    ----------    ----------    ------------     -----------    ------------
    Total revenues ...............................   2,201,722     4,126,245      10,014,425       4,481,127       6,509,929
                                                    ----------    ----------    ------------     -----------    ------------
Cost of revenues:
 Software license and customer support ...........      38,102       190,144         404,848         146,857         233,031
 Professional services(1) ........................     716,059     1,081,021       1,612,167         730,757         879,949
                                                    ----------    ----------    ------------     -----------    ------------
    Total cost of revenues .......................     754,161     1,271,165       2,017,015         877,614       1,112,980
                                                    ----------    ----------    ------------     -----------    ------------
Gross profit .....................................   1,447,561     2,855,080       7,997,410       3,603,513       5,396,949
                                                    ----------    ----------    ------------     -----------    ------------
Operating expenses:
 Selling, general and administrative(2) ..........   1,075,264     2,475,840       6,999,916       2,396,848       7,564,959
 Research and development(3) .....................     365,034     1,162,471       2,597,281       1,129,298       2,471,185
 Stock based compensation ........................     210,695        17,782         138,185          26,391         974,613
 Depreciation and amortization ...................      17,945        93,809         272,548          88,872         342,984
                                                    ----------    ----------    ------------     -----------    ------------
    Total operating expenses .....................   1,668,938     3,749,902      10,007,930       3,641,409      11,353,741
                                                    ----------    ----------    ------------     -----------    ------------
Loss from operations .............................    (221,377)     (894,822)     (2,010,520)        (37,896)     (5,956,792)
                                                    ----------    ----------    ------------     -----------    ------------
Other income (expense):
 Investment earnings .............................           -             -          66,342           2,104          15,769
 Interest expense ................................     (18,523)      (59,910)        (86,538)        (32,927)       (120,005)
 Other ...........................................     (12,404)       (3,313)        (10,642)              -          (8,027)
                                                    ----------    ----------    ------------     -----------    ------------
    Total other income (expense) .................     (30,927)      (63,223)        (30,838)        (30,823)       (112,263)
                                                    ----------    ----------    ------------     -----------    ------------
Loss before income taxes .........................    (252,304)     (958,045)     (2,041,358)        (68,719)     (6,069,055)
Income tax provision (benefit) ...................    (118,224)     (391,291)       (726,343)         12,870               -
                                                    ----------    ----------    ------------     -----------    ------------
Net loss .........................................    (134,080)     (566,754)     (1,315,015)        (81,589)     (6,069,055)
Accretion of transaction costs on redeemable
 convertible preferred stock .....................  $        -    $        -    $     (8,139)    $         -    $     (8,136)
Accrued dividend on redeemable convertible
 preferred stock .................................           -             -        (168,300)              -        (160,002)
                                                    ----------    ----------    ------------     -----------    ------------
Net loss applicable to common shares .............  $ (134,080)   $ (566,754)   $ (1,491,454)    $   (81,589)   $ (6,237,193)
                                                    ==========    ==========    ============     ===========    ============
Basic net loss applicable per common share .......  $    (0.04)   $    (0.16)   $      (0.38)    $     (0.02)   $      (1.48)
                                                    ==========    ==========    ============     ===========    ============
Diluted net loss applicable per common share .....  $    (0.04)   $    (0.16)   $      (0.38)    $     (0.02)   $      (1.48)
                                                    ==========    ==========    ============     ===========    ============
Weighted average common shares outstanding -
 Basic and diluted ...............................   3,132,753     3,611,626       3,874,122       3,795,131       4,202,880
                                                    ==========    ==========    ============     ===========    ============
</TABLE>


------------------

(1) Cost  of revenues -- professional services includes stock based compensation
    of  $105,539,  $-0-,  $-0-,  $-0-,  and  $5,497 for the years ended December
    31,  1997,  1998, and 1999 and the six month periods ended June 30, 1999 and
    2000 (unaudited), respectively.

(2) Selling,  general  and  administrative expenses includes related party legal
    expenses   of   $4,751,   $21,256,   $227,000,  $142,608  and  $136,832  and
    consulting  expenses  of  $-0-,  $34,333,  $120,833, $53,000 and $25,000 and
    excludes  stock  based  compensation  of $76,189, $-0-, $111,019, $9,643 and
    $845,741  for  the  years  ended  December  31, 1997, 1998, and 1999 and six
    month periods ended June 30, 1999 and 2000 (unaudited), respectively.

(3) Research  and  development  expenses  excludes  stock  based compensation of
    $134,506,  $17,782,  $27,166,  $16,748  and  $128,874  for  the  years ended
    December  31,  1997,  1998 and 1999 and the six month periods ended June 30,
    1999 and 2000, (unaudited) respectively.



                See notes to consolidated financial statements.

                                      F-5
<PAGE>

                                INFORMAX, INC.
     CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY (DEFICIT)






<TABLE>
<CAPTION>
                                            COMMON STOCK - VOTING                           COMMON STOCK - NONVOTING
                                         ----------------------------            ----------------------------------------------
                                             ISSUED      OUTSTANDING                  ISSUED         OUTSTANDING
                                             SHARES         SHARES      AMOUNT        SHARES           SHARES         AMOUNT
                                         -------------- ------------- ---------- ---------------- ---------------- ------------
<S>                                      <C>            <C>           <C>        <C>              <C>              <C>
Balance, January 1, 1997 ...............    1,914,822     1,914,822    $ 1,915        1,652,131        1,652,131         1,652
Purchase of treasury stock .............            -      (250,500)         -                          (317,300)
Issuance of stock options ..............            -             -          -                -                -             -
Net loss ...............................            -             -          -                -                -             -
                                            ---------     ---------    -------        ---------        ---------         -----
Balance, December 31, 1997 .............    1,914,822     1,664,322    $ 1,915        1,652,131        1,334,831         1,652
Share options exercised ................            -             -          -          734,967          734,967           735
Issuance of stock options ..............            -             -          -                -                -             -
Amortization of deferred
 compensation on stock options .........            -             -          -                -                -             -
Net loss ...............................            -             -          -                -                -             -
                                            ---------     ---------    -------        ---------        ---------         -----
Balance, December 31, 1998 .............    1,914,822     1,664,322    $ 1,915        2,387,098        2,069,798         2,387
Conversion -- non-voting shares to
 voting ................................      590,178       590,178        590         (590,178)        (590,178)         (590)
Issuance of common stock ...............            -             -          -          100,200          100,200           100
Share options exercised ................            -             -          -          136,940          136,940           137
Issuance of stock options ..............            -             -          -                -                -             -
Amortization of deferred
 compensation on stock options
 and restricted stock ..................            -             -          -                -                -             -
Accretion of transaction costs on
 redeemable convertible preferred
 stock .................................            -             -          -                -                -             -
Accrual of dividend on redeemable
 convertible preferred stock ...........            -             -          -                -                -             -
Net loss ...............................            -             -          -                -                -             -
                                            ---------     ---------    -------        ---------        ---------         -----
Balance, December 31, 1999 .............    2,505,000     2,254,500      2,505        2,034,060        1,716,760         2,034
Share options exercised ................            -             -                   3,257,555        3,257,555         3,257
Issuance of stock options ..............            -             -          -                -                -             -
Issuance of common stock ...............                                                557,193          557,193           557
Issuance of warrants ...................
Adjustments to deferred
 compensation for variable stock
 options and restricted stock ..........            -             -          -                -                -             -
Amortization of deferred
 compensation on stock options
 and restricted stock ..................            -             -          -                -                -             -
Accretion of transaction costs on
 redeemable convertible preferred
 stock .................................            -             -          -                -                -             -
Accrual of dividend on redeemable
 convertible preferred stock ...........            -             -          -                -                -             -
Retirement of treasury stock ...........     (250,500)                    (250)        (317,300)                          (317)
Net loss ...............................            -             -          -                -                -             -
                                            ---------     ---------    -------        ---------        ---------         -----
Balance, June 30, 2000 (unaudited) .....    2,254,500     2,254,500      2,255        5,531,508        5,531,508         5,531
Pro forma conversion of redeemable
 convertible preferred stock to
 common stock (unaudited) ..............      579,979       579,979        580        4,617,081        4,617,081         4,617
                                            ---------     ---------    -------        ---------        ---------         -----
Pro forma conversion of nonvoting
 to voting common stock
 (unaudited) ...........................   10,148,589    10,148,589     10,148      (10,148,589)     (10,148,589)      (10,148)
Pro forma balance, June 30, 2000
 (unaudited) ...........................   12,983,068    12,983,068    $12,983                -                -    $        -
                                           ==========    ==========    =======      ===========      ===========    ==========



<CAPTION>
                                               TREASURY STOCK
                                         ---------------------------
                                                                        ADDITIONAL
                                                                         PAID-IN        DEFERRED      SUBSCRIPTION
                                             SHARES        AMOUNT        CAPITAL     COMPENSATION      RECEIVABLE
                                         ------------- ------------- --------------- -------------- ----------------
<S>                                      <C>           <C>           <C>             <C>            <C>
Balance, January 1, 1997 ...............           -    $         -    $   229,965     $        -     $          -
Purchase of treasury stock .............           -        567,800       (119,000)             -                -
Issuance of stock options ..............           -              -        316,234              -                -
Net loss ...............................           -              -              -              -                -
                                                   -    -----------    -----------     ----------     ------------
Balance, December 31, 1997 .............     567,800       (119,000)       546,199              -                -
Share options exercised ................           -              -          3,666              -                -
Issuance of stock options ..............           -              -         34,000        (34,000)               -
Amortization of deferred
 compensation on stock options .........           -              -              -         17,782                -
Net loss ...............................           -              -              -              -
                                             -------    -----------    -----------     ----------
Balance, December 31, 1998 .............     567,800       (119,000)       583,865        (16,218)               -
Conversion -- non-voting shares to
 voting ................................           -              -              -              -
Issuance of common stock ...............           -              -        101,914        (87,014)               -
Share options exercised ................           -              -         26,305              -
Issuance of stock options ..............           -              -        435,161       (435,161)               -
Amortization of deferred
 compensation on stock options
 and restricted stock ..................           -              -              -        138,185                -
Accretion of transaction costs on
 redeemable convertible preferred
 stock .................................           -              -         (8,139)             -                -
Accrual of dividend on redeemable
 convertible preferred stock ...........           -              -       (168,300)             -                -
Net loss ...............................           -              -              -              -
                                             -------    -----------    -----------     ----------
Balance, December 31, 1999 .............     567,800       (119,000)       970,806       (400,208)               -
Share options exercised ................           -              -        972,060              -          (13,436)
Issuance of stock options ..............           -              -        712,803       (712,803)
Issuance of common stock ...............                                 3,549,454              -       (1,000,000)
Issuance of warrants ...................                                    13,492              -                -
Adjustments to deferred
 compensation for variable stock
 options and restricted stock ..........           -              -        328,835       (328,835)               -
Amortization of deferred
 compensation on stock options
 and restricted stock ..................           -              -              -        980,112                -
Accretion of transaction costs on
 redeemable convertible preferred
 stock .................................           -              -         (8,138)             -                -
Accrual of dividend on redeemable
 convertible preferred stock ...........           -              -       (160,002)             -                -
Retirement of treasury stock ...........    (567,800)       119,000       (118,433)
Net loss ...............................           -              -              -              -
                                            --------    -----------    -----------     ----------
Balance, June 30, 2000 (unaudited) .....           -              -      6,260,877       (461,734)      (1,013,436)
Pro forma conversion of redeemable
 convertible preferred stock to
 common stock (unaudited) ..............           -              -     14,257,997              -                -
                                            --------    -----------    -----------     ----------     ------------
Pro forma conversion of nonvoting
 to voting common stock
 (unaudited) ...........................           -              -              -              -                -
Pro forma balance, June 30, 2000
 (unaudited) ...........................           -    $         -    $20,518,874     $ (461,734)    $ (1,013,436)
                                            ========    ===========    ===========     ==========     ============



<CAPTION>
                                            ACCUMULATED
                                              DEFICIT          TOTAL
                                         ---------------- ---------------
<S>                                      <C>              <C>             <C>
Balance, January 1, 1997 ...............   $   (157,295)   $     76,237
Purchase of treasury stock .............              -               -      (119,000)
Issuance of stock options ..............              -         316,234
Net loss ...............................       (134,080)       (134,080)
                                           ------------    ------------
Balance, December 31, 1997 .............       (291,375)        139,391
Share options exercised ................              -           4,401
Issuance of stock options ..............              -               -
Amortization of deferred
 compensation on stock options .........              -          17,782
Net loss ...............................       (566,754)       (566,754)
                                           ------------    ------------
Balance, December 31, 1998 .............       (858,129)       (405,180)
Conversion -- non-voting shares to
 voting ................................              -               -
Issuance of common stock ...............              -          15,000
Share options exercised ................              -          26,442
Issuance of stock options ..............              -               -
Amortization of deferred
 compensation on stock options
 and restricted stock ..................              -         138,185
Accretion of transaction costs on
 redeemable convertible preferred
 stock .................................              -          (8,139)
Accrual of dividend on redeemable
 convertible preferred stock ...........              -        (168,300)
Net loss ...............................     (1,315,015)     (1,315,015)
                                           ------------    ------------
Balance, December 31, 1999 .............     (2,173,144)     (1,717,007)
Share options exercised ................              -         961,881
Issuance of stock options ..............              -               -
Issuance of common stock ...............                      2,550,011
Issuance of warrants ...................                         13,492
Adjustments to deferred
 compensation for variable stock
 options and restricted stock ..........              -               -
Amortization of deferred
 compensation on stock options
 and restricted stock ..................              -         980,112
Accretion of transaction costs on
 redeemable convertible preferred
 stock .................................              -          (8,138)
Accrual of dividend on redeemable
 convertible preferred stock ...........              -        (160,002)
Retirement of treasury stock ...........                              -
Net loss ...............................     (6,069,055)     (6,069,055)
                                           ------------    ------------
Balance, June 30, 2000 (unaudited) .....     (8,242,199)     (3,448,706)
Pro forma conversion of redeemable
 convertible preferred stock to
 common stock (unaudited) ..............              -      14,263,194
                                           ------------    ------------
Pro forma conversion of nonvoting
 to voting common stock
 (unaudited) ...........................              -               -
Pro forma balance, June 30, 2000
 (unaudited) ...........................   $ (8,242,199)   $ 10,814,488
                                           ============    ============
</TABLE>


                See notes to consolidated financial statements.

                                      F-6
<PAGE>

                                INFORMAX, INC.

                     CONSOLIDATED STATEMENTS OF CASH FLOWS






<TABLE>
<CAPTION>
                                                                                                 SIX MONTHS ENDED
                                                      YEAR ENDED DECEMBER 31,                        JUNE 30,
                                           ---------------------------------------------- ------------------------------
                                                1997           1998            1999            1999           2000
                                           -------------- -------------- ---------------- ------------- ----------------
                                                                                           (UNAUDITED)     (UNAUDITED)
<S>                                        <C>            <C>            <C>              <C>           <C>
Cash flow from operating activities:
 Net loss ................................   $ (134,080)   $   (566,754)   $ (1,315,015)   $  (81,589)    $ (6,069,055)
 Adjustments to reconcile net loss
   to net cash provided by (used
   in) operating activities:
   Depreciation expense ..................       17,945          93,809         272,548        88,872          342,984
   Loss on sale of furniture and
    equipment ............................            -               -           9,840             -            4,312
   Expense related to stock
    options, restricted stock and
    warrants .............................      316,234          17,782         138,185        26,391          993,513
   Deferred income tax benefit ...........     (254,403)       (391,291)       (623,223)      (23,320)               -
   Changes in other assets:
    (Increase) decrease in
      accounts receivable ................     (165,251)     (1,184,462)     (1,090,157)      567,767       (1,025,538)
    (Increase) decrease in income
      tax receivable .....................            -               -        (122,446)            -          122,446
    (Increase) decrease in prepaid
      expenses ...........................            -               -        (222,473)      (49,910)          30,316
    Increase in other current
      assets .............................       (8,073)         (1,362)        (23,762)      (14,551)          (2,535)
    Increase in deposits .................       (4,752)         (4,046)        (57,113)      (39,474)         (13,522)
   Changes in other liabilities:
    Increase in accounts payable .........       53,158         346,669          11,020       324,407          698,511
    Increase (decrease) in accrued
      liabilities ........................      117,483         163,647         591,153      (169,417)        (448,637)
    Increase (decrease) in income
      tax payable ........................      125,638          15,307        (151,296)      (98,355)               -
    Increase (decrease) in billings
      in excess of cost on
      government contracts ...............        8,578          56,218         (79,796)       33,345                -
    Increase (decrease) in
      deferred revenue ...................      350,900       1,388,375          72,395      (290,546)       1,799,059
                                             ----------    ------------    ------------    ----------     ------------
      Cash provided by (used in)
       operating activities ..............      423,377         (66,108)     (2,590,140)      273,620       (3,568,146)
                                             ----------    ------------    ------------    ----------     ------------
Cash flow from investing activities:
 Purchase of furniture and
   equipment .............................       (5,437)        (71,505)     (1,342,908)     (286,808)      (1,306,476)
 Proceeds from sale of furniture
   and equipment .........................            -               -           9,621             -            3,629
 Increase in shareholder note
   receivable ............................            -               -         (65,000)      (65,000)               0
 Repayment of shareholder note
   receivable ............................            -               -               -             -           65,000
      Cash used in investing
       activities ........................       (5,437)        (71,505)     (1,398,287)     (351,808)      (1,237,847)
                                             ----------    ------------    ------------    ----------     ------------

</TABLE>


                                      F-7
<PAGE>



<TABLE>
<CAPTION>
                                                                                                      SIX MONTHS ENDED
                                                         YEAR ENDED DECEMBER 31,                          JUNE 30,
                                              ----------------------------------------------   -------------------------------
                                                  1997            1998             1999             1999             2000
                                              ------------   --------------   --------------   --------------   --------------
                                                                                                 (UNAUDITED)      (UNAUDITED)
<S>                                           <C>            <C>              <C>              <C>              <C>
Cash flow from financing activities:
 Repayments on capital lease
   obligations ............................      (16,915)         (88,390)        (105,532)         (28,130)         (59,813)
 Proceeds from line of credit .............            -          140,509          618,239          368,239        1,500,000
 Repayments on line of credit .............            -                -         (268,239)        (200,000)        (400,000)
 Proceeds from notes payable ..............            -           29,415           92,363           15,193                -
 Proceeds from equipment loan
   facility ...............................            -                -          960,547                -        1,135,000
 Repayment of equipment loan
   facility ...............................            -                -                -                -         (189,574)
 Repayments on notes payable ..............       (5,000)         (35,000)        (156,778)         (79,608)               -
 Purchase of treasury stock ...............      (49,000)               -                -                -                -
 Closing costs for Series A
   redeemable convertible
   preferred stock ........................            -                -          (81,385)         (81,385)               -
 Proceeds from sale of Series A
   redeemable convertible
   preferred stock ........................            -                -        4,000,000        4,000,000                -
 Proceeds from issuance of common
   stock ..................................            -                -           15,000              320        2,550,139
 Proceeds from issuance of warrants........            -                -                -                -               90
 Proceeds from share options
   exercised ..............................            -            4,401           17,480                -          961,755
                                                 -------          -------        ---------        ---------        ---------
      Cash (used in) provided by
       financing activities ...............      (70,915)          50,935        5,091,695        3,994,629        5,497,597
                                                 -------          -------        ---------        ---------        ---------
Net increase (decrease) in cash and
 cash equivalents .........................      347,025          (86,678)       1,103,268        3,916,441          691,604
Beginning cash and cash equivalents .......       35,322          382,347          295,669          295,669        1,398,937
                                                 -------          -------        ---------        ---------        ---------
Ending cash and cash equivalents ..........    $ 382,347       $  295,669       $1,398,937       $4,212,110       $2,090,541
                                               =========       ==========       ==========       ==========       ==========
Supplemental information on noncash
 investing and financing transactions:
 Purchases of equipment through
   capital lease obligations:
 Purchase of equipment ....................    $ (97,071)      $ (296,814)      $  (14,581)      $  (14,581)      $        -
 Increase in capital lease obligations.....       97,071          296,814           14,581           14,581                -
                                               ---------       ----------       ----------       ----------       ----------
                                               $       -       $        -       $        -       $        -       $        -
                                               =========       ==========       ==========       ==========       ==========
 Purchase of treasury stock through
   note payable:
 Increase in notes payable ................    $  70,000       $        -       $        -       $        -       $        -
 Increase in treasury stock ...............      (70,000)               -                -                -                -
                                               ---------       ----------       ----------       ----------       ----------
                                               $       -       $        -       $        -       $        -       $        -
                                               =========       ==========       ==========       ==========       ==========
</TABLE>


                                      F-8
<PAGE>



<TABLE>
<CAPTION>
                                                                                              SIX MONTHS ENDED
                                                     YEAR ENDED DECEMBER 31,                      JUNE 30,
                                              -------------------------------------   --------------------------------
                                                 1997         1998          1999           1999             2000
                                              ----------   ----------   -----------   -------------   ----------------
                                                                                       (UNAUDITED)       (UNAUDITED)
<S>                                           <C>          <C>          <C>           <C>             <C>
Retirement of treasury stock:
Increase in additional paid in capital.....    $     -      $     -      $      -        $     -        $    118,433
Increase in common stock ..................          -            -             -              -                 567
Decrease in treasury stock ................          -            -             -              -            (119,000)
                                               -------      -------      --------        -------        ------------
                                               $     -      $     -      $      -        $     -        $          -
                                               =======      =======      ========        =======        ============
Deferral of offering costs:
Increase in deferred offering costs .......    $     -      $     -      $      -        $     -        $    373,740
Increase in accounts payable ..............          -            -             -              -            (373,740)
                                               -------      -------      --------        -------        ------------
                                               $     -      $     -      $      -        $     -        $          -
                                               =======      =======      ========        =======        ============
Stock purchase through subscription
 receivable:
Increase in subscription receivable .......    $     -      $     -      $      -        $     -        $ (1,013,436)
Increase in additional paid-in capital.....          -            -             -              -           1,013,234
Increase in common stock ..................          -            -             -              -                   -
                                                                                                        ------------
                                               $     -      $     -      $      -        $     -        $        202
                                               =======      =======      ========        =======        ============
Supplemental cash flow information:
 Cash paid for income taxes ...............    $     -      $     -      $151,296        $     -        $          -
                                               =======      =======      ========        =======        ============
 Cash paid for interest ...................    $18,523      $59,910      $ 83,995        $32,927        $    119,229
                                               =======      =======      ========        =======        ============

</TABLE>


                See notes to consolidated financial statements.


                                      F-9
<PAGE>

                    INFORMAX, INC.
                  NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


1.  NATURE OF THE BUSINESS

    InforMax is a global provider of  bioinformatic  software  solutions for the
    analysis and  interpretation  of genomic,  proteomic and other  biomolecular
    data. Bioinformatic software is a key enabling technology,  representing the
    convergence  of  molecular  biology,  information  technology  and  Internet
    communications.  Bioinformatic software,  combined with automated laboratory
    research  technologies,  enables researchers across the numerous disciplines
    using a data driven,  genomic  approach to  biological  discovery to achieve
    greater  efficiency,  productivity and collaboration in their research.  The
    Company's  bioinformatic software solutions make it possible for researchers
    within and across organizations to efficiently organize, integrate, analyze,
    interpret  and  visualize  diverse and rapidly  growing  volumes of genomic,
    proteomic and other biomolecular data. The Company also provides  technology
    consulting  services to the National  Center for  Biotechnology  Information
    (NCBI) under subcontracts.

    InforMax,   Inc.  was   incorporated   in  Delaware  in  May  1990  and  its
    majority-owned subsidiary, InforModus SARL, was organized under the tax laws
    of France in 1997. The Company is headquartered in Rockville,  Maryland, and
    has  sales  offices  in  Rockville,   Maryland;  Annapolis,   Maryland;  San
    Francisco, California; Denver, Colorado; and Oxford, England.



2.  SIGNIFICANT ACCOUNTING POLICIES


    Principles  of  Consolidation  -  The  accompanying  consolidated  financial
    statements  include the  accounts of InforMax,  Inc.  and its 74%  ownership
    interest in its subsidiary.  The minority interest is immaterial in relation
    to the  consolidated  financial  statements.  All  significant  intercompany
    accounts and transactions have been eliminated.


    Basis of  Accounting  - The  accompanying  financial  statements  have  been
    prepared  on  the  accrual  basis  of  accounting  and  in  conformity  with
    accounting principles generally accepted in the United States of America.

    Revenue  Recognition - The Company  derives  revenue  principally  from four
    sources:  software  licensing,  maintenance  fees,  training and  consulting
    services   primarily  under  government   contracts.   Software   licensing,
    maintenance  fees,  and  training  are  presented  as  software  license and
    customer  support on the Consolidated  Statements of Operations.  Consulting
    services  are  presented  as  professional   services  on  the  Consolidated
    Statements of Operations.


    The Company  recognizes  software license revenue based on the provisions of
    Statement of Position  ("SOP") No. 97-2,  Software  Revenue  Recognition (as
    amended  by SOP No.  98-4  and SOP No.  98-9).  Software  license  fees  are
    recognized  as revenue upon the  customer's  execution  of a  non-cancelable
    license agreement and the Company's delivery of the software,  provided that
    the license fee is fixed and determinable,  collectibility is probable,  and
    no  customization  of the software is required.  In connection with software
    licenses,  the Company also enters into  maintenance  contracts that provide
    for technical support and periodic unspecified upgrades.

    During 1997 and 1998,  maintenance  revenue was recognized together with the
    initial  licensing  fee  upon  delivery  of  the  software  when  all of the
    following  were met: (1) the  maintenance  fee was included with the initial
    licensing fee, (2) the maintenance revenue to be recognized was for one year
    or  less,  (3)  the  estimated  cost of  providing  maintenance  during  the
    arrangement  was  insignificant,  and  (4)  any  unspecified  upgrades  were
    expected to be minimal.  In circumstances  where these criteria were not met
    and where fair value for undelivered elements of a multiple element contract
    are not  determinable,  revenue on the contract is entirely  deferred  until
    either fair value is determinable or when all elements are delivered. If the
    Company was unable to establish vendor specific  objective  evidence of fair
    value on the  undelivered  elements  and the only  undelivered  element  was
    maintenance  then all revenue is  recognized  ratably  over the  maintenance
    period.



                                      F-10
<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


     Due to the introduction of new modules,  product enhancements,  and product
     versions,  the Company  increased its  maintenance  support staff and, as a
     result, the estimated cost of providing maintenance services (post-contract
     support  services)  to  customers  was  no  longer  deemed   insignificant.
     Therefore,   beginning  in  January   1999,   revenues  from  all  software
     maintenance  contracts  were  unbundled  from  software  license based upon
     vendor specific objective evidence of fair value and was recognized ratably
     over the  maintenance  period.  Vendor specific objective  evidence of fair
     value for maintenance contracts is determined by the list price established
     by management with the relevant  authority or by the renewal rate specified
     in the contract.  The Company uses the residual method to recognize revenue
     on delivered elements when vendor specific objective evidence of fair value
     has been determined for all undelivered  elements.  Discounts,  if any, are
     applied to the delivered  elements if the residual method is used.  Amounts
     received in advance of the delivery of products or  performance of services
     are classified as deferred revenues.


    Training  is provided on a daily fee basis with  revenue  recognized  as the
    services are provided.

    Consulting services other than under government  contracts are provided on a
    time  and  material  basis  with  revenue  recognized  as the  services  are
    provided.

    During  1997 and 1998,  the  Company's  consulting  services  revenue  under
    government  contracts related to services provided under a time and material
    subcontract  and  a   cost-plus-fixed-fee   subcontract.   During  1999  the
    cost-plus-fixed-fee  subcontract  was  converted at the time of renewal to a
    time and material contract. Revenue under the time and material subcontracts
    is  recognized  based on  contractual  rates as the services  are  provided.
    Revenue  under  the   cost-plus-fixed-fee   subcontract  was  recognized  as
    recoverable  costs were incurred,  including a  proportionate  amount of the
    fixed  fee.  Billings  under  cost  reimbursement  contracts  are  based  on
    provisional  rates.  The  amount  reported  in  the  accompanying  financial
    statements  as  billings  in excess  of costs  results  from the  difference
    between the provisional rates billed and the actual rates incurred.

    Property and  Equipment - Property and  equipment  are stated at cost,  less
    accumulated  depreciation  and  amortization.  Depreciation  on property and
    equipment is computed on a  straight-line  basis over the  estimated  useful
    lives of the assets ranging from three to ten years.  Leasehold improvements
    are depreciated  over the shorter of the estimated useful life of the assets
    or the terms of the related lease.  Repairs and  maintenance are expensed as
    incurred; major improvements and betterments are capitalized.

    Software  Development Costs - Development costs incurred in the research and
    development of new software  products and enhancements to existing  software
    products are expensed as incurred until  technological  feasibility has been
    established.   The  Company  considers   technological   feasibility  to  be
    established  when all  planning,  designing,  coding  and  testing  has been
    completed  according  to  design  specifications.  After  the  technological
    feasibility has been established,  any additional costs would be capitalized
    in  accordance  with  Statement of Financial  Accounting  Standards  No. 86,
    "Accounting  for the  Costs  of  Computer  Software  to be Sold,  Leased  or
    Otherwise  Marketed."  Through December 31, 1999,  software  development has
    been  substantially   completed   concurrently  with  the  establishment  of
    technological feasibility,  and accordingly,  no costs have been capitalized
    to date.

    Income Taxes - The income tax  provision  includes  income  taxes  currently
    payable  plus the net  change  during  the year in  deferred  tax  assets or
    liabilities.  Deferred tax assets and  liabilities  reflect the  differences
    between  the  carrying  value  in  conformity  with  accounting   principles
    generally  accepted in the United States of America and tax values of assets
    and  liabilities  using  enacted  tax  rates  for the  period  in which  the
    differences are expected to reverse.

    Cash and Cash  Equivalents - Cash and cash  equivalents  consist of cash and
    money  market  accounts.  For purposes of the  statement of cash flows,  the
    Company   considers  all  highly  liquid  debt   instruments  with  original
    maturities of three months or less to be cash equivalents.


                                      F-11
<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999

    Concentration  of  Credit  Risk -  Financial  instruments  that  potentially
    subject the Company to a concentration  of credit risks consist  principally
    of cash, cash equivalents,  and accounts  receivable.  The Company generally
    does not require  collateral  on accounts  receivable as the majority of its
    customers  are  well-established  companies,   colleges,   universities  and
    government entities.

    The Company maintains its cash and cash equivalents in bank accounts that at
    times may exceed  federally  insured limits.  At December 31, 1998 and 1999,
    balances of  approximately  $48,000 and  $1,436,000,  respectively,  were in
    excess of the  federally  insured  limit of  $100,000.  The  Company has not
    experienced  any losses in these  accounts and believes it is not exposed to
    any significant credit risk.

    Stock-Based  Compensation  -  In  February  1999,  the  Board  of  Directors
    instituted an Equity  Incentive  Plan (the Plan) intended to qualify as such
    under the provisions of Section 422 of the Internal Revenue Code of 1986, as
    amended. In addition, the Company has issued nonqualified stock options.


    The Company  follows  Financial  Accounting  Standards  Board  Statement  of
    Financial   Accounting   Standards  No.  123,  "Accounting  for  Stock-Based
    Compensation"  (SFAS No. 123). In accounting for stock options, as permitted
    by SFAS No. 123,  the  Company  accounts  for  stock-based  compensation  to
    employees in accordance with Accounting  Principles  Board (APB) Opinion No.
    25, and accordingly,  recognizes compensation expense for fixed stock option
    grants  only  when the  exercise  price is less  than the fair  value of the
    shares on the date of the  grant.  Pro forma  information  is  provided  for
    employee  stock option  grants made in 1997,  1998,  and 1999 as if the fair
    value based method defined in SFAS No. 123 had been applied.

    Evaluation  of  Long-lived  Assets - The  Company  evaluates  the  potential
    impairment of long-lived  assets based upon projections of undiscounted cash
    flows whenever events or changes in circumstances indicate that the carrying
    amount  of an asset may not be fully  recoverable.  Management  believes  no
    impairment of these assets exists at December 31, 1998 and 1999.

    Fair Value of Financial Instruments - The following disclosures of estimated
    fair value were determined by management using available market  information
    and appropriate valuation methodologies.

    The fair  values of the  Company's  financial  instruments,  including  cash
    equivalents,  accounts receivable, accounts payable, accrued expenses, lines
    of credit,  notes  payable and long-term  debt  approximate  their  carrying
    values.

    Disclosure about fair values of financial  instruments is based on pertinent
    information  available  to  management  as of  December  31,  1998 and 1999.
    Although  management  is not aware of any factors  that would  significantly
    affect the reasonable  fair value amounts,  current  estimates of fair value
    may differ significantly from the amounts presented herein.

    Advertising - The Company expenses all advertising costs as incurred.  Total
    advertising  expense was $3,157,  $83,419 and  $612,196  for the years ended
    December 31, 1997, 1998, and 1999, respectively.

    Estimates  and  Assumptions  - The  preparation  of financial  statements in
    conformity  with  accounting  principles  generally  accepted  in the United
    States of America  requires  management to make  estimates and  assumptions.
    These  estimates and assumptions  affect the reported  amounts of assets and
    liabilities, the disclosure of contingent assets and liabilities at the date
    of the financial statements, as well as the reported amounts of revenues and
    expenses during the year.  Actual results could vary from the estimates that
    were used.

    Redeemable  Convertible  Preferred Stock - The Company accretes the increase
    in the  redemption  value of its Series A Redeemable  Convertible  Preferred
    Stock  through  a  charge  to  additional  paid-in  capital  based  upon the
    redemption dates  prescribed in the Series A Preferred Stock Agreement.  The
    period  of  accretion  begins on the June  1999  issue  date and ends on the
    prescribed  redemption date, which is the fifth  anniversary of the original
    issue date.



                                      F-12
<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999

    Net Loss Per Share - Basic net loss per  share has been  computed  using the
    weighted  average  number  of common  shares  outstanding  during  the year:
    diluted net loss per share includes  dilutive stock options and  convertible
    preferred  stock. Due to net operating losses for each of the three years in
    the period  ended  December  31,  1999,  the stock  options and  convertible
    preferred stock are considered antidilutive.


    Unaudited  Pro  forma  Presentation  -  Under  the  terms  of the  Company's
    agreements  with  the  holders  of the  Series  A and  Series  B  Redeemable
    Convertible  Preferred  Stock  (see Notes 7 and 16),  all of such  preferred
    stock will be converted  automatically  into shares of common stock upon the
    closing of the Company's  initial public  offering.  The unaudited pro forma
    balance sheet  information  at June 30, 2000 reflects the  conversion of the
    Series A and Series B preferred stock into 5,197,060  shares of common stock
    as if the conversion  occurred on June 30, 2000. In addition,  the unaudited
    pro forma balance sheet information at June 30, 2000 reflects the conversion
    of the outstanding nonvoting common stock into shares of voting common stock
    as if the conversion occurred on June 30, 2000.

    Reclassifications  -  Certain   reclassifications  have  been  made  to  the
    prior-year financial statements to conform to current-year presentation.

    New  Accounting  Pronouncements  - In June 1998,  the  Financial  Accounting
    Standards Board issued  Statement of Financial  Accounting  Standards (SFAS)
    No. 133,  "Accounting for Derivative  Instruments  and Hedging  Activities,"
    which  establishes   accounting  and  reporting   standards  for  derivative
    instruments  and hedging  activities.  As amended by  Statement of Financial
    Accounting  Standards  No. 137,  this  standard  will be  effective  for the
    Company for fiscal years and quarters beginning after December 31, 2000, and
    requires  that an entity  recognize  all  derivatives  as  either  assets or
    liabilities  in the  statement  of  financial  position  and  measure  those
    instruments  at fair value.  The Company  has not  completed  the process of
    evaluating  the impact  that will  result from  adopting  SFAS No. 133.  The
    Company is therefore  unable to predict the  potential  impact that adopting
    SFAS No. 133 will have on its  financial  position and results of operations
    when such statement is adopted.

    In December 1999, the Securities and Exchange  Commission (SEC) issued Staff
    Accounting  Bulletin  (SAB)  No.  101,  "Revenue  Recognition  in  Financial
    Statements".  This SAB  expresses  the  SEC's  views on  applying  generally
    accepted   accounting   principles  to  revenue   recognition  in  financial
    statements.  The  application of this SAB will not have a material impact on
    the   Company's   financial   statements,   however,   certain   SEC   staff
    interpretations of the SAB have not been published and may have an effect on
    the applicability of the SAB to the consolidated financial statements.

    In  March  2000,  the  Financial  Accounting  Standards  Board  issued  FASB
    Interpretation No. 44, "Accounting for Certain Transactions  Involving Stock
    Compensation,  an  Interpretation of APB Opinion No. 25." With the exception
    of certain provisions which require earlier application, this interpretation
    is effective for all  applicable  transactions  beginning  July 1, 2000. The
    Company does not expect that the adoption of this Interpretation will have a
    material impact on its financial statements.


3.  ACCRUED LIABILITIES

    Accrued  liabilities  consisted of the following as of December 31, 1998 and
    1999:





<TABLE>
<CAPTION>
                                                          1998          1999
                                                       ----------   -----------
<S>                                                    <C>          <C>
   Accrued bonuses .................................    $ 85,000     $182,250
   Accrued interest ................................           -        2,543
   Accrued commissions .............................     224,070      369,105
   Accrued litigation liability (Note 14) ..........           -      228,600
   Other ...........................................      32,902      150,627
                                                        --------     --------
     Total .........................................    $341,972     $933,125
                                                        ========     ========

</TABLE>

                                      F-13
<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999

4.  INCOME TAXES

    The  components of the benefit for income taxes for the years ended December
    31, 1997, 1998, and 1999, were as follows:





<TABLE>
<CAPTION>
                                                          1997            1998            1999
                                                     -------------   -------------   -------------
<S>                                                  <C>             <C>             <C>
   Current provision (benefit):
     Federal .....................................    $  107,599      $        -      $  (86,495)
     State .......................................        28,580               -         (16,625)
                                                      ----------      ----------      ----------
       Total current provision (benefit) .........       136,179               -        (103,120)
                                                      ----------      ----------      ----------
    Deferred benefit:
     Federal .....................................      (208,291)       (324,627)       (504,380)
     State .......................................       (46,112)        (66,664)       (118,843)
                                                      ----------      ----------      ----------
       Total deferred benefit ....................      (254,403)       (391,291)       (623,223)
                                                      ----------      ----------      ----------
       Total benefit for income taxes ............    $ (118,224)     $ (391,291)     $ (726,343)
                                                      ==========      ==========      ==========

</TABLE>

    At December 31, 1998 and 1999, respectively, the components of the Company's
    deferred tax assets and deferred tax liabilities were as follows:



<TABLE>
<CAPTION>
                                                            1998           1999
                                                        -----------   -------------
<S>                                                     <C>           <C>
   Deferred tax assets:
     Deferred revenue ...............................    $449,643      $  699,667
     Compensation relating to stock options .........      64,341          84,838
     Allowance for doubtful accounts ................       5,793           5,793
     Restricted stock ...............................           -          12,530
     Accrued commissions ............................           -          17,909
     Net operating loss .............................     110,450         493,401
     Research and development tax credit ............      23,500               -
                                                         --------      ----------
       Total deferred tax assets ....................     653,727       1,314,138
                                                         --------      ----------
    Deferred tax liabilities:
     Accelerated depreciation .......................      (8,033)        (36,259)
                                                         --------      ----------
       Total deferred tax liabilities ...............      (8,033)        (36,259)
                                                         --------      ----------
       Net deferred tax assets ......................    $645,694      $1,277,879
                                                         ========      ==========

</TABLE>

    At  December  31,  1999,  the  Company  had a  net  federal  operating  loss
    carryforward  of  approximately  $1,277,600,   expiring  in  2019.  The  net
    operating loss generated in 1998 was carried back to 1996 and 1997 resulting
    in an income tax  receivable  of  $122,446  as of  December  31,  1999.  The
    provision for income taxes differs from the amount  computed by applying the
    statutory U.S. Federal income taxes as a result of the following:





<TABLE>
<CAPTION>
                                                                   1997             1998             1999
                                                              --------------   --------------   --------------
<S>                                                           <C>              <C>              <C>
   Statutory U.S. Federal rate ............................        (34.00)%         (34.00)%         (34.00)%

   (Increase) decrease in taxes resulting from: ...........
     State income taxes - net of Federal benefit ..........        ( 4.62)          ( 4.62)          ( 4.38)
     R&D credits ..........................................        ( 8.52)          ( 2.45)               -
     Other ................................................          0.28             0.23             2.80
                                                                   ------           ------           ------
    Effective tax rate ....................................        (46.86)%         (40.84)%         (35.58)%
                                                                   ======           ======           ======
</TABLE>

                                      F-14
<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999

5.  STOCKHOLDERS' EQUITY (DEFICIT)

    Common Stock - The Company has two classes of common  stock.  These  classes
    include a voting class of common stock (Voting Shares) and a nonvoting class
    of common stock  (Nonvoting  Shares).  Voting shares have voting rights with
    respect to all matters  customarily  reserved to holders of a  corporation's
    common stock under the Delaware General Corporation Law. Except with respect
    to the lack of voting  rights,  Nonvoting  Shares have all of the rights and
    interests of the Voting  Shares.  With  respect to the voting  rights of the
    Nonvoting Shares, such shares are only entitled to vote on amendments to the
    Certificate  of  Incorporation  of the Company  that would:  (a) increase or
    decrease the number of authorized nonvoting shares, (b) increase or decrease
    the par value of the  nonvoting  shares,  or (c) alter or change the powers,
    preferences, or special rights of the Nonvoting Shares.


    In February 1999, the Board of Directors approved a 100:1 stock split of all
    of the shares of the common stock of the Company issued and outstanding.  In
    connection  with the  stock  split,  the  Board of  Directors  approved  the
    increase  in the  number of  authorized  shares of  voting  common  stock to
    1,595,455 and the increase in the number of  authorized  shares of nonvoting
    common stock to  14,931,864.  Further,  the Board of Directors  approved the
    exchange of 590,178  shares of nonvoting  common stock for 570,178 shares of
    voting common stock by the President/Chief  Executive Officer. Shares issued
    and outstanding have been adjusted  retroactively  for all periods presented
    to reflect that change in capital structure.

    In 1999, the Board of Directors  granted 100,000 shares of restricted  stock
    to two  consultants  of the  Company.  The  restricted  stock  vests  over a
    four-year period and is subject to service and performance requirements.  At
    the time of grant, the restricted stock and deferred  compensation  relating
    to the issuance of the restricted  stock was recorded based on the estimated
    fair market value of the  Company's  common  stock.  The Company  recognizes
    compensation  expense related to the restricted  stock on a monthly basis as
    the stock is earned and vests,  based upon the difference  between the price
    paid at the original date of issuance and the estimated fair market value of
    the common stock at the end of each subsequent month.  Deferred compensation
    expense is adjusted  monthly to reflect the amount of  compensation  expense
    recognized  and  the  change  in the  estimated  fair  market  value  of the
    Company's  common stock with respect to the unvested  restricted  stock.  In
    relation to the  issuance of this  restricted  stock,  the Company  received
    $15,000 in cash and recorded  compensation  expense in the amount of $32,444
    during the year ended December 31, 1999 and deferred compensation of $54,570
    was included in stockholders' equity (deficit) at December 31, 1999.

    Stock  Options - During 1997,  the Company  granted  1,569,967  nonqualified
    stock options to employees  and one  nonemployee,  all such options  vesting
    immediately. For services rendered, the non-employee received a total of 167
    options  having a fair value based upon the  Black-Scholes  pricing model of
    approximately  $3,400.  The  Company  recorded  compensation  expense in the
    amount of $316,234  during the year ended  December  31, 1997 in relation to
    these  options.  In 1998, the Company  granted  167,000  nonqualified  stock
    options to an  employee,  originally  vesting over a four-year  period.  The
    Company recorded compensation expense relating to 1998 options in the amount
    of $17,782 and $16,218  during the years ended  December  31, 1998 and 1999,
    respectively  and deferred  compensation of $16,218 and $-0- was included in
    stockholders' equity (deficit) at December 31, 1998 and 1999, respectively.

    On February  10,  1999,  the Board of Directors  also  instituted  an equity
    incentive  compensation  plan  (the  Plan).  The  Plan  provides  for  up to
    5,344,000  shares  of  common  stock  of the  Company  for the  granting  of
    restricted  stock and incentive stock options to purchase common stock.  The
    exercise  price per share for an incentive  stock option must be equal to or
    greater than the  estimated  fair market  value,  as determined by the Board
    committee administering the Plan, on the date of grant.



                                      F-15
<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


    In  connection  with the  issuance  of the Series A  Redeemable  Convertible
    Preferred  Stock,  a limit was placed on the number of options that could be
    granted under the Plan. At December 31, 1999, the total shares that could be
    issued under the Plan without  further  approval by the Series A designee to
    the Board was 4,854,783.

    Pursuant  to the  terms  of  the  key  agreement  underlying  the  Company's
    relationship  with one of the  Company's  key  investors,  unless  otherwise
    approved  by the Board of  Directors,  all  stock  options  and other  stock
    equivalents  issued  pursuant  to  agreements  executed  by the  Company  to
    employees,  Directors,  consultants,  and other service  providers  shall be
    subject to vesting as follows:  (a) twenty-five  percent (25%) of such stock
    shall vest at the end of the first year following the earlier of the date of
    issuance or such person's service  commencement  date with the Company,  and
    (b)  seventy-five  (75%) of such stock shall vest over the  remaining  three
    year period subsquent to the end of the first year described in (a).

    During 1999, the Company granted  3,818,804 stock options to employees.  Out
    of the total  stock  option  grants,  746,698  options  vested  immediately,
    111,624  options were forfeited or cancelled,  with the remaining  2,960,480
    options vesting over a four-year period.

    In  February  1999,   the  Board  of  Directors   also  granted   10,938,333
    nonqualified  stock options to the three  employees who were founders of the
    Company.  These stock options vested immediately.  At grant date, the option
    price was equal to the fair value of the Company's common stock.

    During 1999,  the Company also granted  175,350  stock  options  under three
    separate  nonqualified stock option  agreements,  one of which is with a non
    employee director,  the other two were with non employee  advisors.  The non
    employee  director  compensation  expense  was  determined  based  upon  the
    difference between the exercise price and the estimated fair market value of
    the common stock at the date of grant. The Company  recognized  compensation
    expense related to the non-employee advisors nonqualified stock options on a
    monthly basis as the options are earned and vest,  based upon the fair value
    of the options  earned  calculated  using the  Black-Scholes  pricing model.
    Deferred  compensation  expense is adjusted monthly to reflect the amount of
    compensation  expense  recognized and the change in the estimated fair value
    of the unvested nonqualified stock options. Changes in the fair value of the
    unvested  nonqualified  stock  options could result in an increase in future
    compensation  changes.  All of these  options  were  granted  for a ten-year
    period and vest over either three,  four, or five years which coincides with
    the period of  performance.  The number of shares to vest in each year is as
    follows:





<TABLE>
<S>                 <C>
   1999 .........   34,095
   2000 .........   45,364
   2001 .........   42,585
   2002 .........   37,735
   2003 .........   10,561
   2004 .........    5,010

</TABLE>



    In relation to the issuance of the options to the nonemployee director,  the
    Company  recorded  compensation  expense in the amount of $1,998  during the
    year  ended  December  31,  1999 and  deferred  compensation  of $5,502  was
    included in stockholders' equity (deficit) at December 31, 1999. In relation
    to the issuance of options issued to the non-employee  advisors, the Company
    recorded compensation expense in the amount of $51,078 during the year ended
    December  31, 1999 and  deferred  compensation  of $80,889,  was included in
    stockholders' equity (deficit) at December 31, 1999.


    The Company  recorded  compensation  expense  relating  to employee  options
    granted  during 1999 with exercise  prices below the  estimated  fair market
    value at the dates of grant in the amount of


                                      F-16
<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


    $36,447,  and  deferred  compensation  in the amount of  $259,247  which was
    included in stockholders' equity (deficit) at December 31, 1999.


    Option transactions were as follows:





<TABLE>
<CAPTION>
                                                                                          WEIGHTED AVERAGE
                                                                            SHARES         EXERCISE PRICE
                                                                        --------------   -----------------
<S>                                                                     <C>              <C>
   Options outstanding, January 1, 1997 .............................        106,880         $  0.006
     Options granted ................................................      1,569,967            0.006
                                                                           ---------
    Options outstanding, December 31, 1997 ..........................      1,676,847            0.006
     Options granted ................................................        167,000            0.006
     Options exercised ..............................................       (734,967)           0.006
                                                                           ---------
    Options outstanding, December 31, 1998 ..........................      1,108,880            0.006
     Options granted ................................................     14,932,487            0.299
     Options forfeited or cancelled .................................       (111,624)           0.299
     Options exercised ..............................................       (136,940)           0.128
                                                                          ----------
    Options outstanding, December 31, 1999 ..........................     15,792,803            0.280
                                                                          ==========
    Options exercisable as of December 31, 1999 .....................     13,175,805            0.277
                                                                          ==========
    Options available for future grant at December 31, 1999 .........        922,154
                                                                          ==========

</TABLE>


    At December 31, 1999, options outstanding were as follows:





<TABLE>
<CAPTION>
                                    WEIGHTED AVERAGE
                       NUMBER          REMAINING
EXERCISE PRICE      OUTSTANDING     CONTRACTUAL LIFE
----------------   -------------   -----------------
<S>                <C>             <C>
$  0.060             1,028,720         7.8 years
$  0.299            14,764,082         9.3 years

</TABLE>



    The Company has computed the pro forma  disclosures  required under SFAS No.
    123 for all stock options  granted as of December 31, 1997,  1998, and 1999.
    The Company  used the minimum  value  method  permitted  by SFAS No. 123 for
    nonpublic entities for 1997 and 1998. The weighted average fair value at the
    date of grant for options  granted during both 1997 and 1998 was $0.21.  The
    weighted  average exercise price and weighted average fair value at the date
    of grant for options granted during 1999 was as follows:







<TABLE>
<CAPTION>
                                                            EXERCISE PRICE              EXERCISE PRICE
                                                       EQUALS FAIR MARKET VALUE   LESS THAN FAIR MARKET VALUE
                                                      -------------------------- ----------------------------
<S>                                                   <C>                        <C>
  Weighted average exercise price per share .........          $ 0.299                     $ 0.299
  Weighted average fair value per share .............          $ 0.299                     $ 0.968

</TABLE>


    The weighted  average  assumptions  used for options  granted  during fiscal
    years 1997, 1998, and 1999 were as follows:



<TABLE>
<CAPTION>
                                           1997         1998         1999
                                        ----------   ----------   ----------
<S>                                     <C>          <C>          <C>
   Risk-free interest rate ..........   6.50%        6.50%        5.20%
   Expected dividend yield ..........   0.00%        0.00%        0.00%
   Expected life ....................   5 years      5 years      4 years
   Volatility factor ................      0%           0%          13%

</TABLE>

                                      F-17
<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


    The pro forma effects of applying SFAS No. 123 for fiscal years 1997,  1998,
    and 1999 would be as follows:





<TABLE>
<CAPTION>
                                                            1997             1998              1999
                                                       --------------   --------------   ----------------
<S>                                                    <C>              <C>              <C>
   Pro forma net loss ..............................     $ (138,944)      $ (566,897)      $ (1,663,429)
   Pro forma net loss per share - basic ............     $    (0.04)      $    (0.16)      $      (0.43)
   Pro forma net loss per share - diluted ..........     $    (0.04)      $    (0.16)      $      (0.43)

</TABLE>


6.  NET LOSS PER SHARE

    In February 1997,  the Financial  Accounting  Standards  Board (FASB) issued
    SFAS  No.  128,   "Earnings  Per  Share".   This  statement   requires  dual
    presentation  of basic  and  diluted  earnings  per share on the face of the
    income statement. Basic earnings per share is to be computed by dividing net
    income  available to common  shareholders by the weighted  average number of
    common shares  outstanding for the period.  Diluted earnings per share is to
    reflect  the  potential  dilution  that could occur if  securities  or other
    contracts to issue  common  shares were  exercised or converted  into common
    shares for all periods presented.


    The weighted  average  number of common  shares  outstanding  and  potential
    dilutive shares were 4,799,747,  4,685,323 and 17,261,716  relating to stock
    options and redeemable  convertible preferred stock in 1997, 1998, and 1999,
    respectively.


    For the years ended December 31, 1997,  1998, and 1999, the Company incurred
    a net loss; therefore,  all potential common shares are antidilutive and are
    not included in the calculation of the diluted net loss per common share.


7.  REDEEMABLE CONVERTIBLE PREFERRED STOCK

    On June 22,  1999,  the  Company  entered  into a Series A  Preferred  Stock
    Purchase Agreement (the Agreement) with a purchaser. The Company authorized,
    issued,  and  sold  2,161,265  shares  of  Series A  Redeemable  Convertible
    Preferred  Stock,  $.01 par value,  for $4,000,000  ($1.85 per share).  Each
    outstanding share of the Series A Redeemable  Convertible Preferred Stock is
    entitled to the number of votes such that the aggregate  vote of the holders
    of the  Series  A  Redeemable  Convertible  Preferred  Stock is equal to the
    economic  stake such  shares  have in the Company at the record date for the
    determination  of  shareholders  entitled  to  vote  on  such  matters.  The
    purchasers of the Series A Redeemable Convertible Preferred Stock, voting as
    a separate class, exclusive of all other stockholders, are entitled to elect
    one director of the Company.  The holders of the Common  Stock,  voting as a
    separate class,  exclusive of all other stockholders,  are entitled to elect
    four directors. The holders of the Series A Redeemable Convertible Preferred
    Stock and the Voting Common Stock, voting as a single class, are entitled to
    elect one  director.  Such rights with  respect to the election of directors
    terminate upon the effectiveness of the Company's initial public offering.


    The holder of any such shares of Series A Redeemable  Convertible  Preferred
    Stock has the right,  at its option at any time,  to convert any such shares
    of Series A Redeemable  Convertible Preferred Stock into 1.67 fully paid and
    nonassessable shares of Common Stock subsequent to the stock split discussed
    in note 16. Each share of Series A Redeemable Convertible Preferred Stock is
    convertible into the number of shares of Common Stock that would result from
    dividing  the  original  issue  price  per  share  ($1.85)  of the  Series A
    Redeemable  Convertible  Preferred  Stock by the  conversion  price  for the
    Series A  Redeemable  Convertible  Preferred  Stock that is in effect at the
    time of the  conversion.  The  initial  conversion  price  for the  Series A
    Redeemable  Convertible  Preferred Stock is the original issue price for the
    Series A Redeemable Convertible Preferred Stock. The conversion price may be
    adjusted from time to time upon certain conditions,  such as sales of common
    stock, issuance of options and other common stock events.



                                      F-18
<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999

    The  holders  of the Series A  Redeemable  Convertible  Preferred  Stock are
    entitled to receive,  out of funds legally available when and if declared by
    the Board of Directors,  cumulative dividends at the annual dividend rate of
    $.148 per share.  Upon any  liquidation,  dissolution,  or winding up of the
    Company, whether voluntary or involuntary,  or upon redemption,  the holders
    of the Series A Redeemable  Convertible  Preferred Stock are first entitled,
    before any  distribution or payment is made with respect to the Common Stock
    or any other series of capital stock,  to be paid out of available funds and
    assets an amount equal to the "Original Issue Price" ($1.85) for each Series
    A Redeemable Convertible Preferred Stock as adjusted for common stock events
    plus,  in the case of each share,  an amount equal to all accrued  dividends
    unpaid thereon  (whether or not declared) and any other  dividends  declared
    but unpaid  thereon.  The  undeclared  dividends  are being  accreted to the
    redemption  value. The 1999 accrued dividend of $168,300 is presented on the
    Consolidated  Statements of Operations as an addition to net loss applicable
    to common shareholders.


    If, at any time, the Company obtains a firm  commitment-underwritten  public
    offering of shares of Common Stock in which (i) the  aggregate  net proceeds
    of such public  offering  equals or exceeds  $15,000,000 and (ii) the public
    offering  price per share equals or exceeds  $3.32 per share  (adjusted  for
    common stock event), then effective upon closing of the sales of such shares
    by the Company pursuant to such public offering,  all outstanding  shares of
    Series A Redeemable  Convertible  Preferred Stock will automatically convert
    to fully paid nonassessable shares of Common Stock.


    After June 22, 2004,  the fifth  anniversary of the original  issue,  at the
    written request of a majority of the then-outstanding  holders of the Series
    A  Redeemable  Convertible  Preferred  Stock to  redeem at least 20% of such
    shares,  the  Company  shall,  within 60 days,  redeem in cash from  legally
    available  funds,  the  number  of  shares  as  requested  of the  Series  A
    Redeemable  Convertible  Preferred  Stock.  If the  Company  does  not  have
    sufficient  funds legally  available to make full payment in cash or if such
    payment  would  cause the Company to be in  violation  of any  covenants  to
    lenders or others,  then,  within  sixty  days,  the  Company  shall  redeem
    one-third  of  the  Series  A  Redeemable  Convertible  Preferred  Stock  as
    requested in the redemption  notice.  An additional  third shall be redeemed
    one year after the  redemption  notice and the last third  shall be redeemed
    two years after the redemption notice. If the Company is unable to make full
    payment  pursuant to the above,  then the Company  shall redeem the Series A
    Redeemable  Convertible  Preferred Stock in accordance to a payment schedule
    mutually agreed to by the Company and the holders of the Series A Redeemable
    Convertible Preferred Stock.

    The  redemption  price  for each  share of Series A  Redeemable  Convertible
    Preferred Stock shall be equal to the Series A Liquidation  Preference.  The
    Series A Liquidation  Preference is the Original  Issue Price per share,  as
    adjusted for any common stock events,  plus all accrued but unpaid dividends
    whether or not earned or declared.

    The  difference  between  the  carrying  amounts of the Series A  Redeemable
    Convertible  Preferred  Stock of  $4,095,054  at December 31, 1999,  and the
    redemption  amount  of  $4,168,300,   based  upon  the  liquidation  amount,
    represents  the cost of issuance,  which is being accreted pro rata over the
    period beginning on June 22, 1999 issuance date and ending on the prescribed
    redemption date, June 22, 2004. The 1999 accretion of $8,139 is presented on
    the  Consolidated  Statements  of  Operations  as an  addition  to net  loss
    applicable to common shareholders.


8.  LEASE COMMITMENTS

    Operating Leases - The Company leases its headquarters office space under an
    operating  lease that expires in July 2006.  The lease for the  headquarters
    office space  contains an  escalation  clause that  provides  for  increased
    rentals based on an annual  escalation  of 1.03 times the  preceding  year's
    base rent.


                                      F-19
<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999

    As of December 31, 1999,  the Company was  committed to leases for its other
    sales offices with portions of the leases expiring through June 2003.

    Total rental  expense under all office  leases for fiscal years 1997,  1998,
    and 1999 was $61,357, $117,833, and $320,525,  respectively. At December 31,
    1999, future minimum lease payments required under noncancelable leases were
    as follows:





<TABLE>
<CAPTION>
YEAR ENDED DECEMBER 31,
------------------------------------------
<S>                                        <C>
    2000 .................................  $  598,723
    2001 .................................     630,562
    2002 .................................     637,630
    2003 .................................     596,867
    2004 .................................     588,605
    Thereafter ...........................     966,033
                                            ----------
    Total minimum lease payments .........  $4,018,420
                                            ==========

</TABLE>

    Capital Leases - The Company is obligated under capital leases for computers
    and other equipment.  The leases expire at various dates through April 2002.
    The following is a summary of assets under capital leases:





<TABLE>
<CAPTION>
                                                                       DECEMBER 31,
                                                               -----------------------------
                                                                    1998            1999
<S>                                                            <C>             <C>
   Computer equipment ......................................    $  357,202      $  368,723
   Office equipment ........................................        44,728          31,151
                                                                ----------      ----------
   Total ...................................................       401,930         399,874
   Less: Accumulated depreciation and amortization .........      (100,638)       (222,321)
                                                                ----------      ----------
   Assets under capital lease - net ........................    $  301,292      $  177,553
                                                                ==========      ==========

</TABLE>

    Assets under  capital  lease are  depreciated  or  amortized  over three- to
    five-year lives,  with expense totaling $14,991,  $85,090,  and $128,670 for
    the years ended December 31, 1997, 1998, and 1999, respectively.

    The future  minimum  lease  payments  under  capital  leases are computed as
    follows:





<TABLE>
<CAPTION>
YEAR ENDED DECEMBER 31,
--------------------------------------------------------------------
<S>                                                                    <C>
      2000 .........................................................    $  130,940
      2001 .........................................................        85,648
      2002 .........................................................        15,351
                                                                        ----------
                                                                           231,939

    Less: Interest .................................................       (26,438)
                                                                        ----------
    Present value of future minimum capital lease payments .........       205,501
    Less: Current portion ..........................................      (113,293)
                                                                        ----------
    Capital lease obligation, net of current portion ...............    $   92,208
                                                                        ==========

</TABLE>

9.  NOTES PAYABLE

    In  1997,  the  Company  purchased  common  stock  (treasury  stock)  from a
    stockholder  for $49,000 cash and a $70,000 note  payable.  The note payable
    specified  payments of $35,000 in February  1998 and  February  1999 and was
    non-interest bearing.


                                      F-20
<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999

    In 1998, the Company  borrowed $29,415 against an equipment loan facility of
    $125,000.  This note is interest  only monthly,  convertible  on a quarterly
    basis to a thirty-six  month note with  principal  and interest due monthly.
    Borrowings under this note are secured by equipment and accounts  receivable
    and bear  interest at prime plus 1%,  which was 8.75% at December  31, 1998.
    The agreement is  personally  guaranteed  by the  President/Chief  Executive
    Officer. The balance was paid in full during 1999.


10. LINE OF CREDIT AND EQUIPMENT LOAN FACILITY

    At  December  31,  1998,  the  Company had a line of credit in the amount of
    $400,000 that was payable on demand.  Borrowings under this note are secured
    by accounts  receivable  of the  Company and bear  interest at prime plus 2%
    which was 9.75% at December 31, 1998.  The  agreement  required no financial
    covenants and was  personally  guaranteed by the  President/Chief  Executive
    Officer.

    In May 1999,  the Company  paid off the  outstanding  amount on the original
    line of credit  and  outstanding  note  payable  and  obtained a new line of
    credit  in the  amount  of  $1,000,000  consisting  of an  $800,000  secured
    revolving credit line and a $200,000 equipment line of credit.

    In August 1999, the Company  amended  (Amendment No. 1) the May 1999 line of
    credit  agreement to increase the maximum  availability  under the equipment
    line to $600,000.

    In November 1999, the Company amended (Amendment No. 2) the May 1999 line of
    credit  agreement  to increase  the maximum  availability  under each of the
    revolving credit and the equipment line to $1,000,000.  Under this amendment
    interest  rates for the revolving  credit line was adjusted to prime plus 1%
    and the  interest  rate for the  equipment  line was  adjusted to prime plus
    1.25%.

    In 1999, the Company  borrowed  $960,547 against the equipment loan facility
    of $1,000,000.  Any  outstanding  amounts within the first six months of the
    loan plus accrued  interest were converted to a term loan.  Borrowings under
    this note are secured by personal property, including equipment,  trademarks
    and accounts  receivable  of the Company,  bear interest at prime plus 1.25%
    (9.75% at December 31, 1999) and are subject to certain financial covenants.
    In November  1999, all equipment  line advances then  outstanding,  plus any
    accrued interest, were converted to a term loan (the "First Term Loan"). All
    equipment line advances made since the First Term Loan  conversion  shall be
    converted  into a Second Term Loan in May 2000.  Each of the First Term Loan
    and the Second Term Loan shall provide  repayments of principal and interest
    in thirty equal monthly installments. The Company must also maintain various
    financial  covenants,  including  minimum cash balance and certain financial
    ratios. In addition, the Company cannot declare or pay dividends on, or make
    any distribution with respect to, any class of its equity during the term of
    this facility.

    At December 31, 1999,  the amounts  outstanding  under the revolving  credit
    line was $550,000  payable by May 2000 with accrued interest due and payable
    monthly.  Borrowings  under this note are secured by accounts  receivable of
    the Company and bear  interest at prime plus 1% (9.5% at December  31, 1999)
    and are subject to certain financial covenants.

    The following represents the maturities of the equipment loan facility:





<TABLE>
<CAPTION>
   YEAR ENDED DECEMBER 31,    PRINCIPAL DUE
---------------------------- --------------
<S>                          <C>
     2000 ..................    $337,302
     2001 ..................     397,679
     2002 ..................     225,566
                                --------
     Total .................    $960,547
                                ========

</TABLE>

                                      F-21
<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999

11. RELATED PARTY TRANSACTIONS

    The Company had an arrangement with another company,  the president of which
    is also a member of the  Company's  Board of  Directors,  whereby  the other
    company provides advisory and fiduciary oversight services to the Company at
    an average  monthly fee of $2,500.  This  arrangement  ended and was paid in
    full  during  July  1999.  Total fees paid to the other  company  under this
    arrangement  totaled  $26,000 and $50,000 for the years ended  December  31,
    1998 and 1999,  respectively,  and the  Company's  accrued  liability to the
    other  company  was  $2,000 at  December  31,  1998.  There  was no  accrued
    liability at December 31, 1999.

    The Company engaged a law firm during 1997 and 1998. An attorney at the firm
    is also a shareholder of the Company. The Company incurred $4,751 and $2,098
    in  expense to the Firm  during  1997 and 1998,  respectively.  There was no
    accrued liability at December 31, 1997 and 1998, respectively.

    The Company  engaged  another law firm during 1998 and 1999.  An attorney at
    the firm is also a shareholder of the Company.  The Company incurred $19,158
    and $227,039 in expense to the firm and the Company's  accrued  liability to
    the  firm  was  $17,158   and  $21,806  at  December   31,  1998  and  1999,
    respectively.


    Beginning in 1998, the Company has an arrangement  with a shareholder of the
    Company whereby the shareholder  provides consulting services to the Company
    in the form of technical advise on bioinformatics,  gene expression, and the
    use of complex genetic databases,  in addition to marketing of the Company's
    products  in Europe.  This  shareholder  was paid an average  monthly fee of
    $4,167.  Total fees paid to the shareholder  under this arrangement  totaled
    $8,333  and  $50,000  for the  years  ended  December  31,  1998  and  1999,
    respectively,  and the Company's  accrued  liability to the  shareholder was
    $4,167 at December 31, 1998. There was no accrued  liability at December 31,
    1999.

    Beginning in 1999, the Company has an arrangement with a nonqualified  stock
    option holder of the Company whereby the option-holder  provides  consulting
    services to the Company in the form of  bioinformatic  product design advise
    and  information  on market  conditions  and  receptivity  to  bioinformatic
    products,  in addition to chairing  and  recommending  participation  in the
    Company's  Scientific Advisory Board. This option-holder was paid an average
    monthly  fee of  $4,167.  Total  fees paid to the  option-holder  under this
    arrangement totaled $20,833 for the year ended December 31, 1999.


    On April 6, 1999, the Company  loaned the President of the Company  $65,000,
    which is to be paid in full with all unpaid, accrued interest by April 2004.
    The interest rate of this note is prime plus 1% (9.5% at December 31, 1999).
    Interest  income earned during the year and  receivable at December 31, 1999
    was $4,360.

12. BUSINESS SEGMENT AND GEOGRAPHIC AREA INFORMATION

    The Company  operates in one industry  segment,  the development and sale of
    computer software programs and related services.

    Two  customers  accounted  for 26% and 23% of total  accounts  receivable at
    December 31, 1998.  The  Company's  services to NCBI under two  subcontracts
    accounted for 12% of total  accounts  receivable  at December 31, 1998.  One
    customer  accounted for  approximately  14% of total accounts  receivable at
    December 31, 1999. The Company's services to the NCBI under two subcontracts
    accounted for 18% of total accounts receivable at December 31, 1999.

    The  Company's   professional  services  provided  to  the  NCBI  under  two
    subcontracts  accounted for 34% of total revenue for the year ended December
    31, 1998 and 27% of revenue for the year ended December 31, 1999. There were
    no sales to any  individual  country except for the United States where such
    sales accounted for 10% or more of total revenue.


                                      F-22
<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999

    Substantially  all assets are held in the United States at December 31, 1998
    and 1999.

    Revenues by geographic destination and as a percentage of total revenues are
    as follows:





<TABLE>
<CAPTION>
                                                     YEAR ENDED
                                    ---------------------------------------------
                                         1997            1998            1999
                                    -------------   -------------   -------------
<S>                                 <C>             <C>             <C>
   GEOGRAPHIC AREA BY DESTINATION
----------------------------------
   United States ................    $1,843,152      $2,882,439     $ 8,513,617
   International ................       358,570       1,243,806       1,500,808
                                     ----------      ----------     -----------
                                     $2,201,722      $4,126,245     $10,014,425
                                     ==========      ==========     ===========

</TABLE>


<TABLE>
<CAPTION>
                                                 YEAR ENDED
                                    ------------------------------------
                                       1997         1998         1999
                                    ----------   ----------   ----------
<S>                                 <C>          <C>          <C>
   GEOGRAPHIC AREA BY DESTINATION
----------------------------------
   United States ................       84.0%        70.0%        85.0%
   International ................       16.0         30.0         15.0
                                       -----        -----        -----
                                       100.0%       100.0%       100.0%
                                       =====        =====        =====
</TABLE>

13. COMMITMENTS

    Employment  Agreements  -  All  employees  hired  in  1999  have  employment
    agreements  that  entitle  them  to  two  weeks  of  severance  in  case  of
    termination.  In addition,  three  employees of the Company have  employment
    agreements that entitle these  individuals to specified amounts of severance
    if such individuals are terminated.


14. CONTINGENCIES

    Government  Audits - Payments to the Company on subcontracts with prime U.S.
    Government  contractors  are  subject  to  adjustment  upon audit by various
    agencies of the U.S. Government. For the years ended December 31, 1997, 1998
    and 1999, no audits of costs and the related payments have been performed by
    the various agencies.  At December 31, 1998, the Company accrued a potential
    liability for billings in excess of costs  incurred of $79,796  related to a
    cost-plus-fee  contract. In July 1999, this contract was converted to a time
    and  material  based  contract  by signing  new  agreements.  Any  potential
    liabilities  from the prior  contract  ceased under the new  agreements.  At
    December 31, 1999,  there are no liabilities  accrued related to the billing
    in excess of cost. In the opinion of management,  the final determination of
    these  costs and  related  payments  will not have a material  effect on the
    Company's financial position, results of operations, or liquidity.

    Litigation - In late 1998,  litigation was filed in France by a former sales
    representative.  A hearing was held in 1999 and according to the decision of
    the French  court,  the  Company has been  directed  to pay  $228,600 to the
    former representative. The liability of $228,600 was accrued at December 31,
    1999.


15. RETIREMENT PLAN

    Effective January 1, 1999, the Company  established a 401(k) retirement plan
    (the 401(k) Plan)  covering all eligible  employees,  as defined.  Under the
    terms of the 401(k) Plan, participants may defer a portion of their salaries
    as employee  contributions and are immediately 100% vested.  The Company may
    make matching,  nonelective  or  discretionary  contributions  to the 401(k)
    Plan.  In general,  matching  and  discretionary  contributions  made by the
    Company vest ratably  over a three-year  period.  The Company did not make a
    contribution under this Plan for 1999.


                                      F-23
<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999

16. SUBSEQUENT EVENTS

    In  January  2000,  the  Company  joined  in  a  value-added   reseller  and
    comarketing  agreement with another company. The Company grants to the other
    company a  nonexclusive  worldwide  internal  use  license  and  value-added
    reseller license. Each license has a term of two years, and the Company will
    receive a  sublicense  fee for each copy of the product  sublicensed  by the
    other company.


    In January 2000, the Company  joined in agreement with a biotech  company to
    develop a customized  version of its software for use by the biotech company
    in  connection  with  distribution  of the biotech  company's  data  through
    license agreements.  The biotech company agrees to pay for the customization
    of the  product on a  time-and-materials  basis  along  with any  reasonable
    expenses incurred during the customization of the product.


    In February 2000, the Company increased the line of credit to $3,000,000 and
    the equipment line of credit to $3,000,000 (equipment loan). Any outstanding
    amounts on the line of credit are payable by  February  2001;  however,  any
    accrued interest is due and payable  monthly.  Borrowings under this line of
    credit are secured by accounts  receivable  of the Company and bear interest
    at prime plus 1.00% and are subject to certain financial covenants,  such as
    minimum cash balances, net worth, and current ratios. Any outstanding amount
    on the  equipment  loan  within  the first  six  months of the loan plus any
    accrued  interest  shall  be  converted  to a term  loan  in May  2000  with
    principal-and-interest  payments  required monthly over a twenty-four  month
    period.  Borrowings under this loan are secured by equipment of the Company,
    bear interest at prime plus 1.25%, and are subject to a minimum level of net
    worth.

    On June 7, 2000, the Board of Directors  approved the Company's plan to make
    an initial public offering of up to $100,000,000 of common stock.



    On June 7, 2000 the Board of Directors approved an increase in the number of
    authorized  common shares  reserved for issuance under the Company's  equity
    incentive compensation plan to 6,179,000.

    On June 19, 2000, the Company amended (Amendment No. 5) the May 1999 line of
    credit agreement in connection with a $3 million bridge loan. This amendment
    provides a $3 million bridge loan to fund the Company's  operating  expenses
    and modifies certain financial covenants.  All outstanding  borrowings under
    the  bridge  loan will  accrue  interest  at the prime  rate plus 2.5% to be
    payable monthly beginning on July 15, 2000. All outstanding borrowings under
    the bridge loan  together  with any unpaid  interest  accrued  thereon  will
    become due and payable  upon the earlier of (i)  December  19, 2000 and (ii)
    the closing date of any initial public  offering of any capital stock or any
    other equity event in which the Company  receives an infusion of at least $3
    million in cash or non-cash  assets  from any holder of our  capital  stock.
    Generally,  in the event that the Company  raises any funds through  venture
    financing,  private  placements  of  our  equity  securities,  or  strategic
    investors,  the Company is obligated to make a prepayment on the bridge loan
    up to the maximum amount outstanding  thereunder.  The Company may initially
    draw up to $1.5  million and up to $500,000 (in  increments  of $250,000) in
    subsequent  months up to the $3 million maximum  amount.  In connection with
    the bridge  loan the Company  issued to the bank  warrants to purchase up to
    15,030 shares of common stock for $0.006 per warrant.  In the event that any
    amounts under the bridge loan remain due on September 19, 2000,  the Company
    is obligated to issue  additional  10,020 warrants to the bank. The warrants
    are initially  exercisable  at $5.99 per share,  subject to  adjustment  for
    certain dilutive  issuances.  The fair value of each warrant granted will be
    estimated  on the date of the grant using the  Black-Scholes  pricing  model
    with the following weighted average assumptions:  risk-free interest rate of
    5.71%, expected dividend yield of 0%, expected life of one year and expected
    volatility of 12%. A discount on the loan will be recorded equal to the fair
    value of the warrants  and will be  amortized  to interest  expense over the
    term of the  loan.  The bank was also  issued  certain  registration  rights
    enabling them to request the Company to include the common stock  underlying
    their warrants in a registration statement filed by the Company.


                                      F-24

<PAGE>

                                INFORMAX, INC.
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED )
                 YEARS ENDED DECEMBER 31, 1997, 1998, AND 1999


    On June 23, 2000,  the Company  issued  243,282  shares of common stock in a
    private sale transaction  with three accredited  investors and received cash
    totaling approximately $1.55 million.

    On June 29,  2000,  the Company  issued  313,909  share of common stock in a
    private  sale  transaction  to an  accredited  investor  and  received  cash
    totaling  approximately  $2.0  million.  In  addition,  the  Company  issued
    warrants  to  purchase  25,050  shares of common  stock.  The  warrants  are
    initially  exercisable  at $6.37 per share subject to adjustment for certain
    dilutive issuances.


    On June 30,  2000,  in  connection  with the  settlement  and payment of the
    litigation  liability  of $228,600  to the former  sales  representative  in
    France  (see  note  14),  the  Company   purchased  from  the  former  sales
    representative the remaining 26% interest in its subsidiary  InforModas SARL
    for approximately $7,500.


    On April 20, 2000,  the  president  of the Company  paid $65,000  toward the
    interest and principal  outstanding  under the loan that the Company made in
    April  1999.  On July 7, 2000,  the  remaining  principal  and  interest  of
    approximately $6,000 was repaid.

    On  August  16,  2000,  the  Company  entered  into a  Series  B  Redeemable
    Convertible Preferred Stock Purchase Agreement with a purchaser. The Company
    authorized,   issued  and  sold  950,747   shares  of  Series  B  redeemable
    Convertible  Preferred Stock,  $.01 par value,  for $10,000,000  ($10.52 per
    share). The Series B Redeemable Convertible Preferred Stock contains similar
    rights and  privileges  as the  Company's  Series A  Redeemable  Convertible
    Preferred  Stock. In connection with the issuance of the Series B Redeemable
    Convertible  preferred stock, the Company entered into joint development and
    marketing agreements.

    On , 2000, in  connection  with the Company's  contemplated  initial  public
    offering of common stock, the Board of Directors approved a 1.67 for 1 split
    of common  stock,  a change in par value from $0.01 to $0.001,  an income in
    the authorized shares of common stock to 100,000,000,  and the authorization
    of 20,000,000 shares of preferred stock with a par value of $0.01,  prior to
    the closing of the offering.  All references to the number of common shares,
    per share  amounts  and par values  have been  restated  as  appropriate  to
    reflect  the  effect  of the  split and par  value  change  for all  periods
    presented.



17. VALUATION AND QUALIFYING ACCOUNTS

    The following table sets forth activity in the Company's accounts receivable
    reserve accounts:





<TABLE>
<CAPTION>
                                  BALANCE AT                                   BALANCE AT
                                   BEGINNING     CHARGES TO                      END OF
                                   OF PERIOD      EXPENSES      DEDUCTIONS       PERIOD
                                 ------------   ------------   ------------   -----------
<S>                              <C>            <C>            <C>            <C>
   Year ended -
   December 31, 1997 .........      $     -        $     -          $ -         $     -
   December 31, 1998 .........            -         15,000            -          15,000
   December 31, 1999 .........       15,000              -            -          15,000

</TABLE>

                                  * * * * * *

                                      F-25
<PAGE>

--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
      You  should  rely only on the information contained in this prospectus. We
have  not  authorized anyone to provide you with information different from that
contained  in  this  prospectus.  We are offering to sell, and seeking offers to
buy,  shares  of  common  stock only in jurisdictions where offers and sales are
permitted.  The  information contained in this prospectus is accurate only as of
the  date  of  this  prospectus,  regardless  of  the  time  of delivery of this
prospectus or of any sale of our common stock.


      Until          ,  2000,  all  dealers effecting transactions in the common
stock  of  InforMax, Inc., whether or not participating in this offering, may be
required  to  deliver  a  prospectus.  This  is in addition to the obligation of
dealers  to deliver a prospectus when acting as underwriters and with respect to
their unsold allotments or subscriptions.




                       --------------------------------
                               TABLE OF CONTENTS

                       --------------------------------


<TABLE>
<CAPTION>
                                                      PAGE
                                                 --------------
<S>                                              <C>
Prospectus Summary ...........................          3
Risk Factors .................................          9
Special Note Regarding
   Forward-Looking Statements ................         18
Use of Proceeds ..............................         19
Dividend Policy ..............................         19
Capitalization ...............................         20
Dilution .....................................         21
Selected Consolidated Financial Data .........         22
Management's Discussion and Analysis
   of Financial Condition and
   Results of Operations .....................         24
Business .....................................         34
Management ...................................         52
Certain Transactions .........................         62
Principal Stockholders .......................         64
Description of Capital Stock .................         66
Shares Eligible for Future Sale ..............         70
Underwriting .................................         72
Legal Matters ................................         75
Experts ......................................         75
Additional Information .......................         75
Index to Consolidated Financial
   Statements ................................         F-1
</TABLE>


--------------------------------------------------------------------------------
--------------------------------------------------------------------------------




                               [GRAPHIC OMITTED]



                                    SHARES




                                 COMMON STOCK



               ------------------------------------------------
                                   PROSPECTUS
               ------------------------------------------------
                            BEAR, STEARNS & CO. INC.


                           U.S. BANCORP PIPER JAFFRAY

                         ADAMS, HARKNESS & HILL, INC.




                                          , 2000


--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
<PAGE>

                                    PART II

                    INFORMATION NOT REQUIRED IN PROSPECTUS


ITEM 13. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION

     The  following  table  sets  forth  the  various  expenses payable by us in
connection  with  the  registration of the securities offered hereby. All of the
amounts  shown  are  estimated  except  the  Securities  and Exchange Commission
registration  fee,  the  NASD  filing fee and the Nasdaq National Market listing
fee.




<TABLE>
<S>                                                            <C>
Securities and Exchange Commission registration fee. .........  $   24,288
NASD filing fee ..............................................  $    9,700
Nasdaq National Market listing fee ...........................  $   95,000
Transfer agent's and registrar's fees. .......................  $   10,000
Printing expenses ............................................  $  200,000
Legal fees and expenses ......................................  $  500,000
Accounting fees and expenses .................................  $  300,000
Miscellaneous expenses .......................................  $   61,012
                                                                ==========
    Total ....................................................  $1,200,000
                                                                ==========

</TABLE>


* To be completed by amendment.


ITEM 14. INDEMNIFICATION OF OFFICERS AND DIRECTORS

     Under  Section  145  of the General Corporate Law of the State of Delaware,
InforMax  has  broad  powers  to  indemnify  its  directors and officers against
liabilities  they  may incur in such capacities, including liabilities under the
Securities  Act  of  1933,  as amended (the "Securities Act"). InforMax's bylaws
(Exhibit   3.2  hereto)  also  provide  for  mandatory  indemnification  of  its
directors and executive officers.

     InforMax's  certificate of incorporation (Exhibit 3.1 hereto) provides that
the  liability  of its directors for monetary damages shall be eliminated to the
fullest  extent  permissible  under Delaware law. Pursuant to Delaware law, this
includes  elimination  of  liability  for  monetary  damages  for  breach of the
directors'  fiduciary  duty  of  care  to  InforMax  and its stockholders. These
provisions  do  not  eliminate  the  directors' duty of care and, in appropriate
circumstances,   equitable  remedies  such  as  injunctive  or  other  forms  of
non-monetary  relief will remain available under Delaware law. In addition, each
director  will  continue to be subject to liability for breach of the director's
duty  of  loyalty  to  InforMax,  for  acts  or  omissions  not in good faith or
involving  intentional  misconduct,  for  knowing  violations  of  law,  for any
transaction  from  which  the director derived an improper personal benefit, and
for  payment  of  dividends or approval of stock repurchases or redemptions that
are  unlawful  under  Delaware  law.  The  provision  also  does  not  affect  a
director's   responsibilities   under  any  other  laws,  such  as  the  federal
securities laws or state or federal environmental laws.

     InforMax  intends  to  obtain in conjunction with the effectiveness of this
registration  statement a policy of directors' and officers' liability insurance
that  insures  InforMax's  directors  and  officers against the cost of defense,
settlement or payment of a judgment under certain circumstances.

     The  underwriting  agreement  filed  as  Exhibit  1.1  to this registration
statement  provides  for indemnification by the underwriters of InforMax and its
officers  and  directors  for  certain  liabilities arising under the Securities
Act.


                                      II-1
<PAGE>

ITEM 15. RECENT SALES OF UNREGISTERED SECURITIES


     During  the  past  three  years,  the  registrant  has  issued unregistered
securities  to  a limited number of persons as described below (all common stock
amounts are on a post-split basis).

(1) In  August 2000, we issued 950,747 shares of our Series B preferred stock to
    Amersham Pharmacia Biotech, Inc., in exchange for $10 million in cash.

(2) In  June 2000, we issued 313,909 shares of our common stock to an accredited
    investor  for  approximately $2 million, or $6.37 per share. In exchange for
    the  rendering  of  certain  consulting services, we also issued to the same
    accredited  investor  warrants  exercisable  for 25,000 shares of our common
    stock at $6.37 per share, subject to certain adjustments.

(3) In  June  2000, we issued an aggregate of 243,282 shares of our common stock
    to  three  accredited  investors  for  approximately $1.55 million, or $6.37
    per share.

(4) In  June  2000,  we  issued  warrants  exercisable  for 15,030 shares of our
    common  stock  with  an exercise price of $5.99 per share. The warrants were
    issued  in  connection  with  a  $3  million  bridge  loan  financing and we
    received $0.006 per warrant.

(5) In  connection  with  an  equipment  line,  a revolving line of credit and a
    bridge  loan,  we  have  issued notes to the lender covering any outstanding
    amounts under the credit facilities.

(6) In  June 1999, we issued 2,161,265 shares of our Series A preferred stock to
    FBR Technology Venture Partners II, in exchange for $4,000,000 in cash.

(7) In  March  1998,  we  issued  734,967  shares  of  our  common  stock to Dr.
    Titomirov and two investors in exchange for $7,350.

(8) We  have,  from time to time, granted options and restricted stock grants to
    employees,  consultants  and  directors.  The  following  table  sets  forth
    certain information regarding such grants:







<TABLE>
<CAPTION>
YEAR                   NUMBER OF SHARES   RANGE OF EXERCISE PRICE
---------------------- ------------------ ------------------------
<S>                    <C>                <C>
1997                   1,569,967          $ 0.006
1998                   167,000            $ 0.006
1999                   14,932,487         $ 0.30
1/1/2000 - 8/23/2000   1,191,501          $0.30 - $6.37
</TABLE>


     The  sale  and  issuance  of securities in the transactions described above
were  exempt  from  registration under the Securities Act in reliance on Section
4(2)   of   the  Securities  Act  or  Regulation  D  promulgated  thereunder  as
transactions  by an issuer not involving a public offering, where the purchasers
were   sophisticated  investors  who  represented  their  intention  to  acquire
securities  for investment only and not with a view to distribution and received
or had access to adequate information about InforMax.

     No underwriters were employed in the above transactions.

                                      II-2
<PAGE>

ITEM 16. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES


     (A) EXHIBITS






<TABLE>
<CAPTION>
EXHIBIT NO.     DESCRIPTION
-------------   ---------------------------------------------------------------------------------
<S>             <C>
 1.1            Underwriting Agreement *
 3.1            Second Restated Certificate of Incorporation
 3.2            Form of Amended and Restated Certificate of Incorporation (proposed,
                post-offering)*
 3.3            Second Amended and Restated Bylaws
 3.4            Form of Amended and Restated Bylaws (proposed, post-offering)*
 4.1            Specimen Common Stock Certificate *
 5.1            Opinion of Hogan & Hartson L.L.P. *
10.1            InforMax, Inc. Equity Incentive Plan, Amendment No. 1 thereto dated July 11,
                1999 and Amendment No. 2 thereto dated January 25, 2000+
10.2            Employment Agreement between Joseph Lehnen and InforMax, Inc. dated
                April 1, 1999+
10.3            Employment Agreement between Timothy Sullivan and InforMax, Inc. dated
                April 1, 1999+
10.4            Amended and Restated Investor Rights Agreement between InforMax, Inc.,
                FBR Technology Venture Partners II, L.P. and Amersham Pharmacia Biotech,
                Inc. dated August 16, 2000
10.5            Non-Preferred Holder Rights Agreement between InforMax, Inc. and each of
                the Weiss, Peck & Greer entities noted in the Principal Stockholders table dated
                March 29, 2000+
10.6            Shareholder's Agreement among InforMax, Inc., Dr. Alex Titomirov, Dr. James
                Bernstein and certain other stockholders, and Amendment No. 1 thereto dated
                August 17, 1999, and Amendment No. 2 thereto dated March 29, 2000+
10.7            Loan Agreement between InforMax, Inc. and PNC Bank, National Association
                dated May 6, 1999, Amendment No. 1 thereto dated August 6, 1999,
                Amendment No. 2 thereto dated November 30, 1999, Amendment No. 3 thereto
                dated February 7, 2000, Amendment No. 4 thereto dated February 29, 2000 and
                Amendment No. 5 thereto dated June 19, 2000+
10.8            Second Amended and Restated Revolving Credit Note dated February 7, 2000+
10.9            Third Amended and Restated Line of Credit Note dated February 7, 2000+
10.10           Security Agreement between InforMax, Inc. and PNC Bank, National
                Association dated May 6, 1999+
10.11           Office Lease Agreement between InforMax, Inc. and Jemal Cayre 6010
                Executive Blvd. L.L.C. dated March 31, 1999, Addendum No. 1 thereto dated
                July 8, 1999 and Addendum No. 2 thereto dated February 1, 2000 and
                Addendum No. 3 thereto dated May 19, 2000+
10.12           Letter Agreement between InforMax, Inc. and Management System Designers,
                Inc. dated July 9, 1999, in connection with services to be provided to the
                National Center for Biotechnology Information (NCBI), addendum thereto
                dated November 22, 1999, addendum thereto dated November 22, 1999 and
                addendum dated July 26, 2000++
</TABLE>


                                      II-3
<PAGE>



<TABLE>
<CAPTION>
EXHIBIT NO.     DESCRIPTION
-------------   --------------------------------------------------------------------------------
<S>             <C>
10.13           Technical Services Agreement between InforMax, Inc. and Unisys Corporation
                dated April 18, 2000 in connection with services to be provided to the National
                Center for Biotechnology Information (NCBI)++
10.14           Bridge Note dated June 19, 2000+
10.15           Warrant Purchase Agreement between InforMax, Inc and PNC Bank, National
                Association dated June 19, 2000+
10.16           Joinder Agreement between InforMax, Inc. and Paul Capital Partners VI
                Holdings dated June 13, 2000+
10.17           Joinder Agreement between InforMax, Inc. and Cogene Biotech Ventures, L.P.
                dated June 29, 2000+
10.18           Joinder Agreement between InforMax, Inc. and Gene Fund, LP, Kenson
                Venture, LLC and VitalBio Holdings, Inc. and June 23, 2000+
10.19           Data Analysis Products Development and Distribution Agreement dated
                August 16, 2000 between InforMax, Inc. and Amersham Pharmacia Biotech, Inc. *
10.20           Business Information Products Development and Distribution Agreement dated
                August 16, 2000 between InforMax, Inc. and Amersham Pharmacia Biotech, Inc. *
10.21           Employment Agreement between Dr. Vadim Babenko and InforMax, Inc. dated
                July 14, 2000
10.22           Commitment letter dated August 14, 2000 from Dr. Alex Titomirov to
                InforMax, Inc.
10.23           Joinder Agreement between InforMax, Inc. and Gene Fund, LP dated August 16,
                2000
23.1            Consent of Deloitte & Touche LLP
23.2            Consent of Hogan & Hartson L.L.P. (included as part of Exhibit 5.1 hereto) *
23.3            Consent of Front Line Strategic Management Consulting, Inc.
24.1            Power of Attorney of Directors (included in signature pages)
27.1            Financial Data Schedule
</TABLE>



+ previously filed

* To be filed by amendment


+ Confidential Treatment requested as to certain portions of this Exhibit



     (B) FINANCIAL STATEMENT SCHEDULES:

     All  schedules  for  which  provision  is made in the applicable accounting
regulation  of the Securities and Exchange Commission are not required under the
related instructions or are inapplicable, and therefore have been omitted.


ITEM 17. UNDERTAKINGS

     The   undersigned   Registrant   hereby   undertakes   to  provide  to  the
underwriters   at   the   closing   specified   in  the  Underwriting  Agreement
certificates  in  such denominations and registered in such names as required by
the underwriters to permit prompt delivery to each purchaser.

     Insofar  as  indemnification  for  liabilities arising under the Securities
Act  may  be  permitted  to  directors,  officers and controlling persons of the
Registrant  pursuant  to  the  provisions  of  the  Underwriting  Agreement, its
Charter  or  Bylaws  or  the  Delaware General Corporation Law or otherwise, the
Registrant  has  been advised that in the opinion of the Securities and Exchange
Commission  such  indemnification  is  against public policy as expressed in the
Securities Act and is, therefore, unenforceable.


                                      II-4
<PAGE>


     In  the  event  that  a claim for indemnification against such liabilities,
other  than  the  payment  by  the  Registrant of expenses incurred or paid by a
director,  officer,  controlling  person  employee or agent of the Registrant in
the  successful  defense  of any action, suit or proceeding, is asserted by such
director,  officer, controlling person, employee or agent in connection with the
securities  being  registered, the Registrant will, unless in the opinion of its
counsel  the matter has been settled by controlling precedent, submit to a court
of  appropriate  jurisdiction the question whether such indemnification by it is
against  public  policy  as expressed in the Securities Act and will be governed
by the final adjudication of such issue.


     The undersigned Registrant hereby undertakes that:

     (1) For  purposes  of  determining  any liability under the Securities Act,
the  information  omitted  from  the  form  of  prospectus filed as part of this
registration  statement  in  reliance  upon Rule 430A and contained in a form of
prospectus  filed  by the Registrant pursuant to Rule 424(b)(1) or (4) or 497(h)
under  the  Securities  Act  shall  be  deemed  to  be part of this registration
statement as of the time it was declared effective.

     (2) For  the purpose of determining any liability under the Securities Act,
each  post-effective  amendment  that  contains  a  form  of prospectus shall be
deemed  to  be  a  new registration statement relating to the securities offered
therein,  and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.


                                      II-5
<PAGE>

                                  SIGNATURES


     Pursuant  to  the  requirements  of  the Securities Act, InforMax, Inc. has
duly  caused  this Amendment No. 1 to the Registration Statement to be signed on
its  behalf  by  the  undersigned,  thereunto  duly authorized, in the County of
Montgomery, State of Maryland, on August 31, 2000.


                                        INFORMAX, INC.



                                   By:  /S/ Dr. Alex Titomirov
                                        -----------------------------------
                                        Dr. Alex Titomirov
                                        Chairman and Chief Executive Officer


     KNOW  BY  ALL  PERSONS,  that  each  person  whose  signature appears below
constitutes  and  appoints  Dr.  Alex  Titomirov, Dr. James Bernstein and Joseph
Lehnen,  and  each of them, as his true and lawful attorneys-in-fact and agents,
with  full  power  of  substitution and resubstitution, for him and in his name,
place  and  stead,  in  any  and  all capacities, to sign any and all amendments
(including  post-effective  amendments)  to this Registration Statement and sign
any  registration  statement  for  the same offering covered by the Registration
Statement  that  is to be effective upon filing pursuant to Rule 462 promulgated
under  the  Securities  Act  of  1933,  and  to file the same, with all exhibits
thereto,  and  other  documents in connection therewith, with the Securities and
Exchange  Commission,  granting unto said attorneys-in-fact and agents, and each
of  them,  full  power  and  authority  to do and perform each and every act and
thing  requisite  and necessary to be done in connection therewith and about the
premises,  as  fully  to  all  intents  and  purposes as he might or could do in
person,  hereby  ratifying  and  confirming  all that said attorneys-in-fact and
agents,  or  any  of them, or their or his or her substitute or substitutes, may
lawfully do or cause to be done by virtue hereof.







<TABLE>
<CAPTION>
          SIGNATURE                          TITLE                      DATE
-----------------------------   -------------------------------   ----------------
<S>                             <C>                               <C>
/S/ Dr. Alex Titomirov          Chairman of the Board of          August 31, 2000
---------------------------     Directors, President and Chief
Dr. Alex Titomirov              Executive Officer (Principal
                                Executive Officer)

/S/ Joseph Lehnen               Chief Financial Officer           August 31, 2000
---------------------------     (Principal Financial Officer)
Joseph Lehnen

/S/ Dr. James E. Bernstein      Director                          August 31, 2000
---------------------------
Dr. James E. Bernstein

/S/ Harry D'Andrea              Director                          August 31, 2000
---------------------------
Harry D'Andrea

/S/ Hooks Johnston              Director                          August 31, 2000
---------------------------
Hooks Johnston

/S/ Andrew Whiteley             Director                          August 31, 2000
---------------------------
Andrew Whiteley

/S/ Dr. Wei Wu He               Director                          August 31, 2000
---------------------------
Dr. Wei Wu He
</TABLE>


                                      II-6
<PAGE>

                                 EXHIBIT INDEX




<TABLE>
<CAPTION>
EXHIBIT NO.     DESCRIPTION
-------------   ---------------------------------------------------------------------------------
<S>             <C>
 1.1            Underwriting Agreement *
 3.1            Second Restated Certificate of Incorporation
 3.2            Form of Amended and Restated Certificate of Incorporation (proposed,
                post-offering)*
 3.3            Second Amended and Restated Bylaws
 3.4            Form of Amended and Restated Bylaws (proposed, post-offering)*
 4.1            Specimen Common Stock Certificate *
 5.1            Opinion of Hogan & Hartson L.L.P. *
10.1            InforMax, Inc. Equity Incentive Plan, Amendment No. 1 thereto dated July 11,
                1999 and Amendment No. 2 thereto dated January 25, 2000+
10.2            Employment Agreement between Joseph Lehnen and InforMax, Inc. dated
                April 1, 1999+
10.3            Employment Agreement between Timothy Sullivan and InforMax, Inc. dated
                April 1, 1999+
10.4            Amended and Restated Investor Rights Agreement between InforMax, Inc.,
                FBR Technology Venture Partners II, LP and Amersham Pharmacia Biotech,
                Inc. dated August 16, 2000
10.5            Non-Preferred Holder Rights Agreement between InforMax, Inc. and each of
                the Weiss, Peck & Greer entities noted in the Principal Stockholders table dated
                March 29, 2000+
10.6            Shareholder's Agreement among InforMax, Inc., Dr. Alex Titomirov, Dr. James
                Bernstein and certain other stockholders, and Amendment No. 1 thereto dated
                August 17, 1999, and Amendment No. 2 thereto dated March 29, 2000+
10.7            Loan Agreement between InforMax, Inc. and PNC Bank, National Association
                dated May 6, 1999, Amendment No. 1 thereto dated August 6, 1999,
                Amendment No. 2 thereto dated November 30, 1999, Amendment No. 3 thereto
                dated February 7, 2000, Amendment No. 4 thereto dated February 29, 2000 and
                Amendment No. 5 thereto dated June 19, 2000+
10.8            Second Amended and Restated Revolving Credit Note dated February 7, 2000+
10.9            Third Amended and Restated Line of Credit Note dated February 7, 2000+
10.10           Security Agreement between InforMax, Inc. and PNC Bank, National
                Association dated May 6, 1999+
10.11           Office Lease Agreement between InforMax, Inc. and Jemal Cayre 6010
                Executive Blvd. L.L.C. dated March 31, 1999, Addendum No. 1 thereto dated
                July 8, 1999 and Addendum No. 2 thereto dated February 1, 2000 and
                Addendum No. 3 thereto dated May 19, 2000+
10.12           Letter Agreement between InforMax, Inc. and Management System Designers,
                Inc. dated July 9, 1999, in connection with services to be provided to the
                National Center for Biotechnology Information (NCBI), addendum thereto
                dated November 22, 1999, addendum thereto dated November 22, 1999 and
                addendum dated July 26, 2000++
10.13           Technical Services Agreement between InforMax, Inc. and Unisys Corporation
                dated April 18, 2000 in connection with services to be provided to the National
                Center for Biotechnology Information (NCBI)+
</TABLE>


                                      II-7
<PAGE>



<TABLE>
<CAPTION>
EXHIBIT NO.     DESCRIPTION
-------------   ------------------------------------------------------------------------------
<S>             <C>
10.14           Bridge Note dated June 19, 2000+
10.15           Warrant Purchase Agreement between InforMax, Inc and PNC Bank, National
                Association dated June 19, 2000+
10.16           Joinder Agreement between InforMax, Inc. and Paul Capital Partners VI
                Holdings dated June 13, 2000+
10.17           Joinder Agreement between InforMax, Inc. and Cogene Biotech Ventures, L.P.
                dated June 29, 2000+
10.18           Joinder Agreement between InforMax, Inc. and Gene Fund, LP, Kenson
                Venture, LLC and VitalBio Holdings, Inc. and June 23, 2000+
10.19           Data Analysis Products Development and Distribution Agreement dated
                August 16, 2000 between InforMax, Inc. and Amersham Pharmacia Biotech, Inc. *
10.20           Business Information Products Development and Distribution Agreement dated
                August 16, 2000 between InforMax, Inc. and Amersham Pharmacia Biotech, Inc. *
10.21           Employment Agreement between Dr. Vadim Babenko and InforMax, Inc. dated
                July 14, 2000
10.22           Commitment letter dated August 14, 2000 from Dr. Alex Titomirov to
                Informax, Inc.
10.23           Joinder Agreement between InforMax Inc. and Gene Fund, LP dated August 16,
                2000
23.1            Consent of Deloitte & Touche LLP
23.2            Consent of Hogan & Hartson L.L.P. (included as part of Exhibit 5.1 hereto) *
23.3            Consent of Front Line Strategic Management Consulting, Inc.
24.1            Power of Attorney of Directors (included in signature pages)
27.1            Financial Data Schedule
</TABLE>



+ previously filed
* To be filed by amendment
+ Confidential Treatment requested as to certain portions of this Exhibit


                                      II-8




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