INFORMAX INC
S-1/A, 2000-09-19
COMPUTER PROGRAMMING SERVICES
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  AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON SEPTEMBER 19, 2000
                                                     REGISTRATION NO. 333-41194

================================================================================

                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                              ------------------
                                AMENDMENT NO. 3

                                       TO

                                    FORM S-1
                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933

                              ------------------
                                INFORMAX, INC.
            (Exact name of registrant as specified in its charter)



<TABLE>
<S>                                   <C>                            <C>
                  DELAWARE                        7371                    56-1687783
    (State or other jurisdiction of   (Primary Standard Industrial      (IRS Employer
     incorporation or organization)    Classification Code Number)   Identification No.)
</TABLE>


                              ------------------

   6010 EXECUTIVE BOULEVARD, 10TH FLOOR, ROCKVILLE, MD 20852, (301) 984-2206
(Address,  including  zip  code,  and  telephone number, including area code, of
                   registrant's principal executive offices)

                               JOSEPH E. LEHNEN
                            CHIEF FINANCIAL OFFICER
                     6010 EXECUTIVE BOULEVARD, 10TH FLOOR
                              ROCKVILLE, MD 20852
                                (301) 984-2206
(Name,  address,  including zip code, and telephone number, including area code,
                             of agent for service)


                              ------------------
                                   COPIES TO:

<TABLE>
<S>                                       <C>
              MICHAEL J. SILVER                 JEFFREY E. COHEN
           Hogan & Hartson L.L.P.               Coudert Brothers
    111 S. Calvert Street, Suite 1600     1114 Avenue of the Americas
             Baltimore, MD 21202               New York, NY 10036
             (410) 659-2700                      (212) 626-4400
</TABLE>


                              ------------------
     Approximate  date  of  commencement of proposed sale to the public: As soon
as practicable after the Effective Date of this Registration Statement.

     If  any  of  the securities being registered on this Form are to be offered
on  a  delayed or continuous basis pursuant to Rule 415 under the Securities Act
of 1933, check the following box. [ ]

     If  this  Form  is  filed to register additional securities for an offering
pursuant  to  Rule  462(b) under the Securities Act, check the following box and
list  the  Securities Act registration statement number of the earlier effective
registration statement for the same offering. [ ]

     If  this  Form  is a post-effective amendment filed pursuant to Rule 462(c)
under  the  Securities  Act, check the following box and list the Securities Act
registration  statement  number  of the earlier effective registration statement
for the same offering. [ ]

     If  this  Form  is a post-effective amendment filed pursuant to Rule 462(d)
under  the  Securities  Act, check the following box and list the Securities Act
registration  statement  number  of the earlier effective registration statement
for the same offering. [ ]


     If  delivery of the prospectus is expected to be made pursuant to Rule 434,
check the following box. [ ]


     THE  REGISTRANT  HEREBY  AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES  AS  MAY  BE  NECESSARY  TO  DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT
SHALL  FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION
STATEMENT  SHALL  THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE  SECURITIES  ACT, OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME EFFECTIVE
ON  SUCH  DATE  AS  THE  COMMISSION,  ACTING  PURSUANT TO SAID SECTION 8(A), MAY
DETERMINE.
================================================================================
<PAGE>


                                EXPLANATORY NOTE

     This Amendment No. 3 to the Registration Statement is being filed solely to
file three  alternate  pages for the prospectus  contained in Amendment No. 2 to
the Registration  Statement filed on September 12, 2000, and to file Exhibit 1.1
to the Registration  Statement.  The alternate pages,  marked  "Alternate Page,"
will only be used with copies of the prospectus  delivered outside of the United
States to non-U.S.  persons.  With the exception of these three alternate pages,
the prospectus to be delivered outside of the United States to non-U.S.  persons
is identical to that contained in Amendment No. 2 to the Registration Statement.

<PAGE>


                                [Alternate Page]


                SUBJECT TO COMPLETION, DATED SEPTEMBER 19, 2000


PRELIMINARY PROSPECTUS


                               5,000,000 SHARES


                               [GRAPHIC OMITTED]


                                  COMMON STOCK
                              ------------------

     This  is  an initial public offering of 5,000,000 shares of common stock of
InforMax,  Inc.  We  are selling all of the shares of common stock offered under
this prospectus.

     We  expect  the  public  offering  price for our common stock to be between
$14.00  and $16.00 per share. There is currently no public market for our common
stock.  We  have  applied  to  have our common stock approved for listing on the
Nasdaq National Market under the symbol "INMX."

     SEE  "RISK FACTORS" BEGINNING ON PAGE 9 TO READ ABOUT RISKS THAT YOU SHOULD
CONSIDER BEFORE BUYING SHARES OF OUR COMMON STOCK.

     NEITHER  THE  SECURITIES  AND  EXCHANGE COMMISSION NOR ANY OTHER REGULATORY
BODY  HAS  APPROVED OR DISAPPROVED THESE SECURITIES OR PASSED ON THE ADEQUACY OR
ACCURACY  OF  THIS  PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL
OFFENSE.

                              ------------------

<TABLE>
<CAPTION>
                                                     PER SHARE       TOTAL
                                                    -----------   ----------
<S>                                                 <C>           <C>
Public offering price ...........................     $            $
Underwriting discounts and commissions ..........     $            $
Proceeds to InforMax, Inc. ......................     $            $
</TABLE>

                              ------------------

     We  have  granted  the  underwriters  a  30-day option to purchase up to an
additional  750,000  shares  of  common  stock  from  us  at  the initial public
offering price less the underwriting discount.

     The  underwriters  are severally underwriting the shares being offered. The
underwriters  expect to deliver the shares in New York, New York on      , 2000.

                              ------------------

BEAR, STEARNS INTERNATIONAL LIMITED

                           U.S. BANCORP PIPER JAFFRAY

                                                   ADAMS, HARKNESS & HILL, INC.


                  The date of this prospectus is        , 2000

THE  INFORMATION  IN  THIS  PRELIMINARY  PROSPECTUS  IS  NOT COMPLETE AND MAY BE
CHANGED.  WE  MAY  NOT  SELL  THESE  SECURITIES UNTIL THE REGISTRATION STATEMENT
FILED  WITH THE SECURITIES AND EXCHANGE COMMISSION IS EFFECTIVE. THIS PROSPECTUS
IS  NOT  AN OFFER TO SELL THESE SECURITIES, AND IT IS NOT SOLICITING AN OFFER TO
BUY  THESE  SECURITIES,  IN  ANY  JURISDICTION  WHERE  THE  OFFER OR SALE IS NOT
PERMITTED.


<PAGE>


                                [Alternate Page]

     No  action  has  been  or  will  be  taken in any jurisdiction by us or any
underwriter  that  would  permit  a  public  offering  of  the  common  stock or
possession  or  distribution of this prospectus in any jurisdiction where action
for  that  purpose  is  required,  other than in the United States. Persons into
whose  possession  this prospectus comes are required by us and the underwriters
to  inform themselves about, and to observe any restrictions as to, the offering
of the common stock and the distribution of this prospectus.

     The  shares  may not be offered to persons in the United Kingdom other than
in  circumstances  which  are  deemed  not  to  be an offer to the public in the
United  Kingdom  for the purposes of the Public Offers of Securities Regulations
1995.  Neither this prospectus, nor any other document issued in connection with
the  offering  of  the  shares may be issued to any person in the United Kingdom
unless  that  person  is  of  a kind described in Article 11(3) of the Financial
Services  Act  1986  (Investment  Advertisements)  (Exemptions)  Order  1996 (as
amended)  or is a person to whom such document may be otherwise lawfully issued.


<PAGE>

                                [Alternate Page]

================================================================================

      You  should  rely only on the information contained in this prospectus. We
have  not  authorized anyone to provide you with information different from that
contained  in  this  prospectus.  We are offering to sell, and seeking offers to
buy,  shares  of  common  stock only in jurisdictions where offers and sales are
permitted.  The  information contained in this prospectus is accurate only as of
the  date  of  this  prospectus,  regardless  of  the  time  of delivery of this
prospectus or of any sale of our common stock.

      Until          ,  2000,  all  dealers effecting transactions in the common
stock  of  InforMax, Inc., whether or not participating in this offering, may be
required  to  deliver  a  prospectus.  This  is in addition to the obligation of
dealers  to deliver a prospectus when acting as underwriters and with respect to
their unsold allotments or subscriptions.

                               -----------------
                               TABLE OF CONTENTS
                               -----------------
<TABLE>
<CAPTION>
                                                      PAGE
                                                      ----
<S>                                                   <C>
Prospectus Summary ...........................          3
Risk Factors .................................          9
Special Note Regarding
   Forward-Looking Statements ................         18
Use of Proceeds ..............................         19
Dividend Policy ..............................         19
Capitalization ...............................         20
Dilution .....................................         22
Selected Consolidated Financial Data .........         23
Management's Discussion and Analysis
   of Financial Condition and
   Results of Operations .....................         25
Business .....................................         35
Management ...................................         53
Certain Transactions .........................         63
Principal Stockholders .......................         65
Description of Capital Stock .................         67
Shares Eligible for Future Sale ..............         71
Underwriting .................................         73
Legal Matters ................................         76
Experts ......................................         76
Additional Information .......................         76
Index to Consolidated Financial
   Statements ................................         F-1
</TABLE>

================================================================================

================================================================================

                               [GRAPHIC OMITTED]


                               5,000,000 SHARES


                                 COMMON STOCK


                                   ----------
                                   PROSPECTUS
                                   ----------

                                 BEAR, STEARNS
                             INTERNATIONAL LIMITED

                           U.S. BANCORP PIPER JAFFRAY

                         ADAMS, HARKNESS & HILL, INC.


                                          , 2000

================================================================================



<PAGE>

                                    PART II

                    INFORMATION NOT REQUIRED IN PROSPECTUS


ITEM 13. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION

     The  following  table  sets  forth  the  various  expenses payable by us in
connection  with  the  registration of the securities offered hereby. All of the
amounts  shown  are  estimated  except  the  Securities  and Exchange Commission
registration  fee,  the  NASD  filing fee and the Nasdaq National Market listing
fee.



<TABLE>
<S>                                                            <C>
Securities and Exchange Commission registration fee. .........  $   24,288
NASD filing fee ..............................................  $    9,700
Nasdaq National Market listing fee ...........................  $   95,000
Transfer agent's and registrar's fees. .......................  $   10,000
Printing expenses ............................................  $  200,000
Legal fees and expenses ......................................  $  500,000
Accounting fees and expenses .................................  $  300,000
Miscellaneous expenses .......................................  $   61,012
                                                                ==========
    Total ....................................................  $1,200,000
                                                                ==========




</TABLE>



ITEM 14. INDEMNIFICATION OF OFFICERS AND DIRECTORS

     Under  Section  145  of the General Corporate Law of the State of Delaware,
InforMax  has  broad  powers  to  indemnify  its  directors and officers against
liabilities  they  may incur in such capacities, including liabilities under the
Securities  Act  of  1933,  as amended (the "Securities Act"). InforMax's bylaws
(Exhibit   3.2  hereto)  also  provide  for  mandatory  indemnification  of  its
directors and executive officers.

     InforMax's  certificate of incorporation (Exhibit 3.1 hereto) provides that
the  liability  of its directors for monetary damages shall be eliminated to the
fullest  extent  permissible  under Delaware law. Pursuant to Delaware law, this
includes  elimination  of  liability  for  monetary  damages  for  breach of the
directors'  fiduciary  duty  of  care  to  InforMax  and its stockholders. These
provisions  do  not  eliminate  the  directors' duty of care and, in appropriate
circumstances,   equitable  remedies  such  as  injunctive  or  other  forms  of
non-monetary  relief will remain available under Delaware law. In addition, each
director  will  continue to be subject to liability for breach of the director's
duty  of  loyalty  to  InforMax,  for  acts  or  omissions  not in good faith or
involving  intentional  misconduct,  for  knowing  violations  of  law,  for any
transaction  from  which  the director derived an improper personal benefit, and
for  payment  of  dividends or approval of stock repurchases or redemptions that
are  unlawful  under  Delaware  law.  The  provision  also  does  not  affect  a
director's   responsibilities   under  any  other  laws,  such  as  the  federal
securities laws or state or federal environmental laws.

     InforMax  intends  to  obtain in conjunction with the effectiveness of this
registration  statement a policy of directors' and officers' liability insurance
that  insures  InforMax's  directors  and  officers against the cost of defense,
settlement or payment of a judgment under certain circumstances.

     The  underwriting  agreement  filed  as  Exhibit  1.1  to this registration
statement  provides  for indemnification by the underwriters of InforMax and its
officers  and  directors  for  certain  liabilities arising under the Securities
Act.


                                      II-1
<PAGE>

ITEM 15. RECENT SALES OF UNREGISTERED SECURITIES

     During  the  past  three  years,  the  registrant  has  issued unregistered
securities  to  a limited number of persons as described below (all common stock
amounts are on a post-split basis).

(1) In  August 2000, we issued 950,747 shares of our Series B preferred stock to
    Amersham Pharmacia Biotech, Inc., in exchange for $10 million in cash.


(2) In  June 2000, we issued 313,909 shares of our common stock to an accredited
    investor  for  approximately $2 million, or $6.37 per share. In exchange for
    the  rendering  of  certain  consulting services, we also issued to the same
    accredited  investor  warrants  exercisable  for 25,050 shares of our common
    stock at $6.37 per share, subject to certain adjustments.


(3) In  June  2000, we issued an aggregate of 243,282 shares of our common stock
    to  three  accredited  investors  for  approximately $1.55 million, or $6.37
    per share.

(4) In  June  2000,  we  issued  warrants  exercisable  for 15,030 shares of our
    common  stock  with  an exercise price of $5.99 per share. The warrants were
    issued  in  connection  with  a  $3  million  bridge  loan  financing and we
    received $0.006 per warrant.

(5) In  connection  with  an  equipment  line,  a revolving line of credit and a
    bridge  loan,  we  have  issued notes to the lender covering any outstanding
    amounts under the credit facilities.

(6) In  June 1999, we issued 2,161,265 shares of our Series A preferred stock to
    FBR Technology Venture Partners II, in exchange for $4,000,000 in cash.


(7) In  March  1998,  we  issued  734,967  shares  of  our  common  stock to Dr.
    Titomirov and two investors in exchange for $4,401.


(8) We  have,  from time to time, granted options and restricted stock grants to
    employees,  consultants  and  directors.  The  following  table  sets  forth
    certain information regarding such grants:






<TABLE>
<CAPTION>
YEAR                   NUMBER OF SHARES   RANGE OF EXERCISE PRICE
---------------------- ------------------ ------------------------
<S>                    <C>                <C>
1997                   1,569,967          $ 0.006
1998                   167,000            $ 0.006
1999                   14,932,487         $ 0.299
1/1/2000 - 8/23/2000   1,191,581          $0.299 - $6.371
</TABLE>


     The  sale  and  issuance  of securities in the transactions described above
were  exempt  from  registration under the Securities Act in reliance on Section
4(2)   of   the  Securities  Act  or  Regulation  D  promulgated  thereunder  as
transactions  by an issuer not involving a public offering, where the purchasers
were   sophisticated  investors  who  represented  their  intention  to  acquire
securities  for investment only and not with a view to distribution and received
or had access to adequate information about InforMax.

     No underwriters were employed in the above transactions.

                                      II-2
<PAGE>

ITEM 16. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES


     (A) EXHIBITS






<TABLE>
<CAPTION>
EXHIBIT NO.     DESCRIPTION
-------------   ---------------------------------------------------------------------------------
<S>             <C>
 1.1            Form of Underwriting Agreement
 3.1            Second Restated Certificate of Incorporation of InforMax, Inc. as amended by Certificate of
                Amendment to the Certificate of Incorporation dated September 11, 2000.+
 3.2            Form of Restated Certificate of Incorporation (proposed, post-offering)+
 3.3            Second Amended and Restated Bylaws of InforMax, Inc.+
 3.4            Form of Restated Bylaws (proposed, post-offering)+
 4.1            Specimen Common Stock Certificate *
 5.1            Opinion of Hogan & Hartson L.L.P. *
10.1            InforMax, Inc. Equity Incentive Plan, Amendment No. 1 thereto dated July 11,
                1999 and Amendment No. 2 thereto dated January 25, 2000+
10.2            Employment Agreement between Joseph Lehnen and InforMax, Inc. dated
                April 1, 1999+
10.3            Employment Agreement between Timothy Sullivan and InforMax, Inc. dated
                April 1, 1999+
10.4            Amended and Restated Investor Rights Agreement between InforMax, Inc.,
                FBR Technology Venture Partners II, L.P. and Amersham Pharmacia Biotech,
                Inc. dated August 16, 2000+
10.5            Non-Preferred Holder Rights Agreement between InforMax, Inc. and each of
                the Weiss, Peck & Greer entities noted in the Principal Stockholders table dated
                March 29, 2000+
10.6            Shareholder's Agreement among InforMax, Inc., Dr. Alex Titomirov, Dr. James
                Bernstein and certain other stockholders, and Amendment No. 1 thereto dated
                August 17, 1999, and Amendment No. 2 thereto dated March 29, 2000+
10.7            Loan Agreement between InforMax, Inc. and PNC Bank, National Association
                dated May 6, 1999, Amendment No. 1 thereto dated August 6, 1999,
                Amendment No. 2 thereto dated November 30, 1999, Amendment No. 3 thereto
                dated February 7, 2000, Amendment No. 4 thereto dated February 29, 2000 and
                Amendment No. 5 thereto dated June 19, 2000+
10.8            Second Amended and Restated Revolving Credit Note dated February 7, 2000+
10.9            Third Amended and Restated Line of Credit Note dated February 7, 2000+
10.10           Security Agreement between InforMax, Inc. and PNC Bank, National
                Association dated May 6, 1999+
10.11           Office Lease Agreement between InforMax, Inc. and Jemal Cayre 6010
                Executive Blvd. L.L.C. dated March 31, 1999, Addendum No. 1 thereto dated
                July 8, 1999 and Addendum No. 2 thereto dated February 1, 2000 and
                Addendum No. 3 thereto dated May 19, 2000+
10.12           Letter Agreement between InforMax, Inc. and Management System Designers,
                Inc. dated July 9, 1999, in connection with services to be provided to the
                National Center for Biotechnology Information (NCBI), addendum thereto
                dated November 22, 1999, addendum thereto dated November 22, 1999 and
                addendum dated July 26, 2000++
10.13           Technical Services Agreement between InforMax, Inc. and Unisys Corporation
                dated April 18, 2000 in connection with services to be provided to the National
                Center for Biotechnology Information (NCBI)++
</TABLE>


                                      II-3
<PAGE>



<TABLE>
<CAPTION>
EXHIBIT NO.     DESCRIPTION
-------------   -----------------------------------------------------------------------------
<S>             <C>
10.14           Bridge Note dated June 19, 2000+
10.15           Warrant Purchase Agreement between InforMax, Inc and PNC Bank, National
                Association dated June 19, 2000+
10.16           Joinder Agreement between InforMax, Inc. and Paul Capital Partners VI
                Holdings dated June 13, 2000+
10.17           Joinder Agreement between InforMax, Inc. and Cogene Biotech Ventures, L.P.
                dated June 29, 2000+
10.18           Joinder Agreement between InforMax, Inc. and Gene Fund, LP, Kenson
                Venture, LLC and VitalBio Holdings, Inc. and June 23, 2000+
10.19           Data Analysis Products Development and Distribution Agreement dated
                August 16, 2000 between InforMax, Inc. and Amersham Pharmacia Biotech, Inc.+
10.20           [Reserved].
10.21           Employment Agreement between Dr. Vadim Babenko and InforMax, Inc. dated
                July 14, 2000+
10.22           Commitment letter dated August 14, 2000 from Dr. Alex Titomirov to
                InforMax, Inc.+
10.23           Joinder Agreement between InforMax, Inc. and Gene Fund, LP dated August 16,
                2000+
23.1            Consent of Deloitte & Touche LLP+
23.2            Consent of Hogan & Hartson L.L.P. (included as part of Exhibit 5.1 hereto) *
23.3            Consent of Front Line Strategic Management Consulting, Inc.+
24.1            Power of Attorney of Directors (included in signature pages)+
27.1            Financial Data Schedule
</TABLE>


+ previously filed
* To be filed by amendment

+ Confidential Treatment requested as to certain portions of this Exhibit


     (B) FINANCIAL STATEMENT SCHEDULES:

     All  schedules  for  which  provision  is made in the applicable accounting
regulation  of the Securities and Exchange Commission are not required under the
related instructions or are inapplicable, and therefore have been omitted.


ITEM 17. UNDERTAKINGS

     The   undersigned   Registrant   hereby   undertakes   to  provide  to  the
underwriters   at   the   closing   specified   in  the  Underwriting  Agreement
certificates  in  such denominations and registered in such names as required by
the underwriters to permit prompt delivery to each purchaser.

     Insofar  as  indemnification  for  liabilities arising under the Securities
Act  may  be  permitted  to  directors,  officers and controlling persons of the
Registrant  pursuant  to  the  provisions  of  the  Underwriting  Agreement, its
Charter  or  Bylaws  or  the  Delaware General Corporation Law or otherwise, the
Registrant  has  been advised that in the opinion of the Securities and Exchange
Commission  such  indemnification  is  against public policy as expressed in the
Securities Act and is, therefore, unenforceable.

     In  the  event  that  a claim for indemnification against such liabilities,
other  than  the  payment  by  the  Registrant of expenses incurred or paid by a
director,  officer,  controlling  person  employee or agent of the Registrant in
the  successful  defense  of any action, suit or proceeding, is asserted by such
director,  officer, controlling person, employee or agent in connection with the
securities being


                                      II-4
<PAGE>

registered,  the  Registrant  will,  unless  in  the  opinion of its counsel the
matter  has  been  settled  by  controlling  precedent,  submit  to  a  court of
appropriate  jurisdiction  the  question  whether  such indemnification by it is
against  public  policy  as expressed in the Securities Act and will be governed
by the final adjudication of such issue.

     The undersigned Registrant hereby undertakes that:

     (1) For  purposes  of  determining  any liability under the Securities Act,
the  information  omitted  from  the  form  of  prospectus filed as part of this
registration  statement  in  reliance  upon Rule 430A and contained in a form of
prospectus  filed  by the Registrant pursuant to Rule 424(b)(1) or (4) or 497(h)
under  the  Securities  Act  shall  be  deemed  to  be part of this registration
statement as of the time it was declared effective.

     (2) For  the purpose of determining any liability under the Securities Act,
each  post-effective  amendment  that  contains  a  form  of prospectus shall be
deemed  to  be  a  new registration statement relating to the securities offered
therein,  and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.


                                      II-5
<PAGE>

                                  SIGNATURES



     Pursuant  to  the  requirements  of  the Securities Act, InforMax, Inc. has
duly  caused  this Amendment No. 3 to the Registration Statement to be signed on
its  behalf  by  the  undersigned,  thereunto  duly authorized, in the County of
Montgomery, State of Maryland, on September 19, 2000.



                                        INFORMAX, INC.



                                   By:  /S/ Dr. Alex Titomirov
                                        -----------------------------------

                                        Dr. Alex Titomirov
                                        Chairman and Chief Executive Officer

     Pursuant  to  the  requirements of the Securities Act, this Amendment No. 3
to  the  Registration  Statement has been signed by the following persons in the
capacities and on such dates disclosed below







<TABLE>
<CAPTION>
          SIGNATURE                          TITLE                        DATE
-----------------------------   -------------------------------   -------------------
<S>                             <C>                               <C>
/S/ Dr. Alex Titomirov          Chairman of the Board of          September 19, 2000
---------------------------     Directors, President and Chief
Dr. Alex Titomirov              Executive Officer (Principal
                                Executive Officer)


             *                  Chief Financial Officer           September 19, 2000
---------------------------     (Principal Financial Officer)
Joseph Lehnen


             *                  Director                          September 19, 2000
---------------------------
Dr. James E. Bernstein


             *                  Director                          September 19, 2000
---------------------------
Harry D'Andrea


             *                  Director                          September 19, 2000
---------------------------
Hooks Johnston


               *                Director                          September 19, 2000
---------------------------
Andrew Whiteley


               *                Director                          September 19, 2000
---------------------------
Dr. Wei Wu He
</TABLE>


------------------
* By  his  signature  below, the undersigned, pursuant to duly authorized powers
  of  attorney  filed  with  the  Securities and Exchange Commission, has signed
  this  Amendment  No.  3 to the registration statement on behalf of the persons
  indicated.




/S/ Dr. Alex Titomirov
---------------------------
Dr. Alex Titomirov



                                      II-6
<PAGE>

                                 EXHIBIT INDEX




<TABLE>
<CAPTION>
EXHIBIT NO.     DESCRIPTION
-------------   ---------------------------------------------------------------------------------
<S>             <C>
 1.1            Form of Underwriting Agreement
 3.1            Second Restated Certificate of Incorporation of InforMax, Inc. as amended by Certificate of
                Amendment to the Certificate of Incorporation dated September 11, 2000.+
 3.2            Form of Restated Certificate of Incorporation (proposed, post-offering)+
 3.3            Second Amended and Restated Bylaws of InforMax, Inc.+
 3.4            Form of Restated Bylaws (proposed, post-offering)+
 4.1            Specimen Common Stock Certificate *
 5.1            Opinion of Hogan & Hartson L.L.P. *
10.1            InforMax, Inc. Equity Incentive Plan, Amendment No. 1 thereto dated July 11,
                1999 and Amendment No. 2 thereto dated January 25, 2000+
10.2            Employment Agreement between Joseph Lehnen and InforMax, Inc. dated
                April 1, 1999+
10.3            Employment Agreement between Timothy Sullivan and InforMax, Inc. dated
                April 1, 1999+
10.4            Amended and Restated Investor Rights Agreement between InforMax, Inc.,
                FBR Technology Venture Partners II, L.P. and Amersham Pharmacia Biotech,
                Inc. dated August 16, 2000+
10.5            Non-Preferred Holder Rights Agreement between InforMax, Inc. and each of
                the Weiss, Peck & Greer entities noted in the Principal Stockholders table dated
                March 29, 2000+
10.6            Shareholder's Agreement among InforMax, Inc., Dr. Alex Titomirov, Dr. James
                Bernstein and certain other stockholders, and Amendment No. 1 thereto dated
                August 17, 1999, and Amendment No. 2 thereto dated March 29, 2000+
10.7            Loan Agreement between InforMax, Inc. and PNC Bank, National Association
                dated May 6, 1999, Amendment No. 1 thereto dated August 6, 1999,
                Amendment No. 2 thereto dated November 30, 1999, Amendment No. 3 thereto
                dated February 7, 2000, Amendment No. 4 thereto dated February 29, 2000 and
                Amendment No. 5 thereto dated June 19, 2000+
10.8            Second Amended and Restated Revolving Credit Note dated February 7, 2000+
10.9            Third Amended and Restated Line of Credit Note dated February 7, 2000+
10.10           Security Agreement between InforMax, Inc. and PNC Bank, National
                Association dated May 6, 1999+
10.11           Office Lease Agreement between InforMax, Inc. and Jemal Cayre 6010
                Executive Blvd. L.L.C. dated March 31, 1999, Addendum No. 1 thereto dated
                July 8, 1999 and Addendum No. 2 thereto dated February 1, 2000 and
                Addendum No. 3 thereto dated May 19, 2000+
10.12           Letter Agreement between InforMax, Inc. and Management System Designers,
                Inc. dated July 9, 1999, in connection with services to be provided to the
                National Center for Biotechnology Information (NCBI), addendum thereto
                dated November 22, 1999, addendum thereto dated November 22, 1999 and
                addendum dated July 26, 2000++
10.13           Technical Services Agreement between InforMax, Inc. and Unisys Corporation
                dated April 18, 2000 in connection with services to be provided to the National
                Center for Biotechnology Information (NCBI)++
</TABLE>



                                      II-7
<PAGE>



<TABLE>
<CAPTION>
EXHIBIT NO.     DESCRIPTION
-------------   -----------------------------------------------------------------------------
<S>             <C>
10.15           Warrant Purchase Agreement between InforMax, Inc and PNC Bank, National
                Association dated June 19, 2000+
10.16           Joinder Agreement between InforMax, Inc. and Paul Capital Partners VI
                Holdings dated June 13, 2000+
10.17           Joinder Agreement between InforMax, Inc. and Cogene Biotech Ventures, L.P.
                dated June 29, 2000+
10.18           Joinder Agreement between InforMax, Inc. and Gene Fund, LP, Kenson
                Venture, LLC and VitalBio Holdings, Inc. and June 23, 2000+
10.19           Data Analysis Products Development and Distribution Agreement dated
                August 16, 2000 between InforMax, Inc. and Amersham Pharmacia Biotech, Inc.+
10.20           [Reserved].
10.21           Employment Agreement between Dr. Vadim Babenko and InforMax, Inc. dated
                July 14, 2000+
10.22           Commitment letter dated August 14, 2000 from Dr. Alex Titomirov to
                InforMax, Inc.+
10.23           Joinder Agreement between InforMax Inc. and Gene Fund, LP dated August 16,
                2000+
23.1            Consent of Deloitte & Touche LLP+
23.2            Consent of Hogan & Hartson L.L.P. (included as part of Exhibit 5.1 hereto) *
23.3            Consent of Front Line Strategic Management Consulting, Inc.+
24.1            Power of Attorney of Directors (included in signature pages)+
27.1            Financial Data Schedule
</TABLE>


+ previously filed
* To be filed by amendment

+ Confidential Treatment requested as to certain portions of this Exhibit

                                      II-8



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