INFORMAX INC
S-1/A, EX-10.22, 2000-08-31
COMPUTER PROGRAMMING SERVICES
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                                                                        EX-10.22

                                 August 14, 2000

InforMax, Inc.
10th Floor
6010 Executive Boulevard
Rockville, Maryland  20852

Gentlemen:

     This  letter  sets  forth the  commitments  I am making to  InforMax,  Inc.
("InforMax"  or "the  Company") in connection  with an equity  investment in the
Company by Amersham Pharmacia Biotech, Inc. ("APB").

     I agree to continue to serve as Chief Executive  Officer and/or Chairman of
the  Board  of  Directors  of  InforMax,  devoting  at  least a  majority  of my
professional  working time to the business of InforMax,  for a period of two (2)
years from the date of this letter or for eighteen  (18) months from the date of
an initial public offering  ("IPO") by InforMax,  whichever is later;  provided,
that, in no event shall this  commitment  extend beyond three (3) years from the
date  hereof;  and,  provided  further,  that I receive  no less than my current
salary, benefits and Board approved bonuses from time-to-time no less than those
awarded to other senior management.

     I also agree that,  for so long as I am an  officer,  employee or holder of
more than 10% of the outstanding shares of InforMax, and for a period of two (2)
years after I cease to be an officer, employee or holder of more than 10% of the
outstanding  shares of  InforMax,  I will not directly  render  services for any
business  engaged in the business in which InforMax is engaged at the time of my


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termination  or any  business  in which  the  Board of  Directors  has given the
management  of  InforMax  the  approval  to  engage  in as  of  the  date  of my
termination;  provided,  that both parties agree that  RealTimeHealth.com,  Inc.
("RTH")  is not  competitive  with the  Company  and thus  not  covered  by this
provision;  and, provided further, that I am not precluded from investing in any
funds which invest in biotechnology or other companies.

     I also agree that,  for so long as I am an  officer,  employee or holder of
more than 10% of the outstanding  shares of InforMax and for a period of two (2)
years after I cease to be an officer, employee or holder of more than 10% of the
outstanding  shares of InforMax,  I will not,  directly or  indirectly,  hire or
engage  or  attempt  to hire or engage  any  individual  who shall  have been an
employee  of InforMax as of the date I cease to be an officer or employee of the
Company  or at any time  during  the one (1)  year  period  prior to such  date,
whether  for or on my own  behalf or for any  entity in which I have a direct or
indirect interest.

     I acknowledge  that,  prior to and  following the Company's  planned IPO, I
will not sell or attempt to sell any shares of stock, options, warrants or other
equity  interest I have in InforMax for a period of six (6) months from the date
of such IPO;  provided,  that, this commitment  shall not restrict my ability to
sell any such equity interests should the currently-filed S-1 be withdrawn.

     I further  acknowledge  that,  if I breach or  attempt to breach any of the
commitments set forth herein,  (i) InforMax may, for a period of sixty (60) days
after such breach or attempted breach becomes known to InforMax,  seek to enjoin
me from further breaches or attempted breaches, or seek to compel me to


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comply with such commitments by specific  performance,  in addition to any other
remedies  available  in equity or at law;  and (ii) after a period of sixty (60)
days from the time any such breach or attempted breach becomes known to InforMax
or APB,  APB may, if and only if InforMax  has not  successfully  enjoined  such
breach or attempted breach, seek to enjoin me from further breaches or attempted
breaches,  or seek to compel me to comply  with  such  commitments  by  specific
performance, in addition to any other remedies available in equity or at law, as
a third-party beneficiary of the foregoing commitments.

     Nothing   contained   herein  shall  be  interpreted  to  limit  any  other
obligations  I have with  respect  to the  Company's  business  pursuant  to the
Shareholder's   Agreement   dated   September  1,  1999  and  the   Confidential
Information,   Non-Competition,   Non-Solicitation  and  Intellectual   Property
Agreement that I have dated June 22, 1999.


                                             Very truly yours,

                                             /s/ Alexander Titomirov
                                             -----------------------------------
                                             Dr. Alexander Titomirov


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