<TABLE> <S> <C>

<PAGE>

<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE
PLANETRX.COM, INC. FORM 10-Q FOR THE PERIOD ENDED JUNE 30, 2000 AND IS QUALIFIED
IN ITS ENTIRETY BY REFERENCE TO SUCH FINANCIAL STATEMENTS.
</LEGEND>
<MULTIPLIER> 1,000

<S>                             <C>
<PERIOD-TYPE>                   6-MOS
<FISCAL-YEAR-END>                          DEC-31-2000
<PERIOD-START>                             JAN-01-2000
<PERIOD-END>                               JUN-30-2000
<CASH>                                          50,608
<SECURITIES>                                         0
<RECEIVABLES>                                        0
<ALLOWANCES>                                         0
<INVENTORY>                                      2,967
<CURRENT-ASSETS>                                24,463
<PP&E>                                          20,714
<DEPRECIATION>                                   5,038
<TOTAL-ASSETS>                                 258,013
<CURRENT-LIABILITIES>                           21,198
<BONDS>                                          4,929
                                0
                                          0
<COMMON>                                             5
<OTHER-SE>                                     229,353
<TOTAL-LIABILITY-AND-EQUITY>                   258,013
<SALES>                                          8,132
<TOTAL-REVENUES>                                 9,435
<CGS>                                            7,825
<TOTAL-COSTS>                                    8,034
<OTHER-EXPENSES>                                45,929
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                               (615)
<INCOME-PRETAX>                               (43,913)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                           (43,913)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                  (43,913)
<EPS-BASIC>                                     (0.92)<F1>
<EPS-DILUTED>                                   (0.92)

<FN>
<F1>  Reflects basic EPS according to SFAS 128
</FN>

</TABLE>



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