<TABLE> <S> <C>

<PAGE>

<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE
PLANETRX.COM,INC. FORM 10-Q FOR THE PERIOD ENDED SEPTEMBER 30, 2000 AND IS
QUALIFIED IN ITS ENTIRETY BY REFERENCE TO SUCH FINANCIAL STATEMENTS.
</LEGEND>
<MULTIPLIER> 1,000

<S>                             <C>
<PERIOD-TYPE>                   9-MOS
<FISCAL-YEAR-END>                          DEC-31-2000
<PERIOD-START>                             JAN-01-2000
<PERIOD-END>                               JUN-30-2000
<CASH>                                          25,248
<SECURITIES>                                         0
<RECEIVABLES>                                        0
<ALLOWANCES>                                         0
<INVENTORY>                                      3,018
<CURRENT-ASSETS>                                42,240
<PP&E>                                          24,783
<DEPRECIATION>                                   7,010
<TOTAL-ASSETS>                                 217,693
<CURRENT-LIABILITIES>                           17,141
<BONDS>                                          3,783
                                0
                                          0
<COMMON>                                             5
<OTHER-SE>                                     195,132
<TOTAL-LIABILITY-AND-EQUITY>                   258,013
<SALES>                                          9,078
<TOTAL-REVENUES>                                 9,942
<CGS>                                            8,705
<TOTAL-COSTS>                                    8,713
<OTHER-EXPENSES>                                35,559
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                               (290)
<INCOME-PRETAX>                               (34,040)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                           (34,040)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                  (34,040)
<EPS-BASIC>                                     (0.70)<F1>
<EPS-DILUTED>                                   (0.70)
<FN>
<F1>Reflects Basic EPS according to SFAS 128
</FN>


</TABLE>



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