EQUITY INVESTOR FUND FOCUS SER BIOTECH 1999 SERIES B DAF
S-6/A, 1999-10-06
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    As filed with the Securities and Exchange Commission on October 5, 1999
                                                     Registration No. 333-83261
===============================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                            -----------------------
                               Amendment No. 1
                                      to
                                    FORM S-6
                            -----------------------

               FOR REGISTRATION UNDER THE SECURITIES ACT OF 1933
                    OF SECURITIES OF UNIT INVESTMENT TRUSTS
                           REGISTERED ON FORM N-8B-2

                             --------------------

A.   Exact Name of Trust:
                             EQUITY INVESTOR FUND
                                 FOCUS SERIES
                          BIOTECHNOLOGY 1999 SERIES B
                          (FORMERLY FOCUS SERIES 12)
                              DEFINED ASSET FUNDS

B.   Names of Depositor:

               MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED

C.   Complete address of Depositor's principal executive offices:

                     MERRILL LYNCH, PIERCE, FENNER & SMITH
                                 INCORPORATED
                              DEFINED ASSET FUNDS
                                 P.O. BOX 9051
                          PRINCETON, N.J. 08543-9051


D.   Name and complete address of Agent for service:

                             TERESA KONCICK, ESQ.
                                 P.O. BOX 9051
                          PRINCETON, N.J. 08543-9051

                            -----------------------

                                   Copies to:
                          PIERRE DE SAINT PHALLE, ESQ.
                             DAVIS POLK & WARDWELL
                              450 LEXINGTON AVENUE
                            NEW YORK, NEW YORK 10017
                            -----------------------


E:   Title of Securities being registered:

     AN INDEFINITE NUMBER OF UNITS OF BENEFICIAL INTEREST PURSUANT TO RULE
     24F-2 PROMULGATED UNDER THE INVESTMENT COMPANY ACT OF 1940, AS AMENDED.

F:   Approximate date of proposed sale to the public:

          AS SOON AS PRACTICABLE AFTER THE ACQUISITION AND DEPOSIT OF THE
          UNDERLYING SECURITIES.

                            -----------------------

THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR DATES
AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL FILE
A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION STATEMENT
SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF THE
SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME
EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(A),
MAY DETERMINE.

===============================================================================


<PAGE>



                                    PART II
             ADDITIONAL INFORMATION NOT INCLUDED IN THE PROSPECTUS

       A. The following information relating to the Depositors is incorporated
by reference to the SEC filings indicated and made a part of this Registration
Statement.

I.   Bonding arrangements of each of the Depositors are incorporated by
     reference to Item A of Part II to the Registration Statement on Form S-6
     under the Securities Act of 1933 for Municipal Investment Trust Fund,
     Monthly Payment Series--573 Defined Asset Funds (Reg. No. 333-08241).

II.  The date of organization of each of the Depositors is set forth in Item B
     of Part II to the Registration Statement on Form S-6 under the Securities
     Act of 1933 for Municipal Investment Trust Fund, Monthly Payment
     Series--573 Defined Asset Funds (Reg. No. 333-08241) and is herein
     incorporated by reference thereto.

III. The Charter and By-Laws of each of the Depositors are incorporated herein
     by reference to Exhibits 1.3 through 1.12 to the Registration Statement on
     Form S-6 under the Securities Act of 1933 for Municipal Investment Trust
     Fund, Monthly Payment Series--573 Defined Asset Funds (Reg. No.
     333-08241).

IV.  Information as to Officers and Directors of the Depositors has been filed
     pursuant to Schedules A and D of Form BD under Rules 15b1-1 and 15b3-1 of
     the Securities Exchange Act of 1934 and is incorporated by reference to
     the SEC filings indicated and made a part of this Registration Statement:

                                                              IDENTIFICATION NO.

Merrill Lynch, Pierce, Fenner & Smith Incorporated..........       8-7221

     B. The Internal Revenue Service Employer Identification Numbers of the
Sponsor and Trustee are as follows:

Merrill Lynch, Pierce, Fenner & Smith Incorporated..........     13-5674085
The Bank of New York........................................     13-4941102

     Final prospectuses from the following Series of Defined Asset Funds-Equity
Investor Fund (all of which are incorporated herein by reference) may be used as
preliminary prospectuses for this Series: EIF Focus Series Biotechnology
Portfolio DAF (Reg. No. 333-48303); EIF Select Series Amex Institutional
Portfolio DAF (Reg. No. 333-50911); and EIF Select Large-Cap Growth Portfolio
DAF (Reg. No. 333-60519).




                                      II-1

<PAGE>



                       CONTENTS OF REGISTRATION STATEMENT

     THE REGISTRATION STATEMENT ON FORM S-6 COMPRISES THE FOLLOWING PAPERS AND
DOCUMENTS:

     The facing sheet of Form S-6. The Cross-Reference Sheet (incorporated by
reference to the Cross-Reference Sheet to the Registration Statement of the
Equity Income Fund, Sixth Utility Common Stock Series, 1933 Act File No.
2-86836). The Prospectus. Additional Information not included in the Prospectus
(Part II).

     The following exhibits:

    *1.1   --  Form of Trust Indenture.

     1.1.1 --  Form of Standard Terms and Conditions of Trust Effective October
               21, 1993 (incorporated by reference to Exhibit 1.1.1 to the
               Registration Statement of Municipal Investment Trust Fund,
               Multistate Series-48, Defined Asset Funds, 1933 Act File No.
               33-50247).

     1.2   --  Form of Master Agreement Among Underwriters (incorporated by
               reference to Exhibit 1.2 to the Registration Statement of The
               Corporate Income Fund, One Hundred Ninety-Fourth Monthly Payment
               Series, 1933 Act File No. 2-90925).

     2.1   --  Form of Certificate of Beneficial Interest (included in Exhibit
               1.1.1).

    *3.1   --  Opinion of counsel as to the legality of the securities being
               issued including their consent to the use of their names under
               the heading "How the Fund Works--Legal Opinion" in the
               Prospectus.

     9.1   --  Information Supplement (incorporated by reference to Exhibit 9.1
               to the Registration Statement of Equity Investor Fund, Select Ten
               Portfolio 1999 International Series A (United Kingdom Portfolio),
               File No. 333-70593).
- -------------------
*    To be filed with Amendment to Registration Statement.


                                      R-1

<PAGE>



                                   SIGNATURES

     PURSUANT TO THE REQUIREMENTS OF THE SECURITIES ACT OF 1933, THE REGISTRANT
HAS DULY CAUSED THIS REGISTRATION STATEMENT OR AMENDMENT TO THE REGISTRATION
STATEMENT TO BE SIGNED ON ITS BEHALF BY THE UNDERSIGNED THEREUNTO DULY
AUTHORIZED IN THE CITY OF NEW YORK AND STATE OF NEW YORK ON THE 5TH DAY OF
OCTOBER, 1999.

     Signatures appear on page R-3.

     A majority of the members of the Board of Directors of Merrill Lynch,
Pierce, Fenner & Smith Incorporated has signed this Registration Statement or
Amendment to the Registration Statement pursuant to Powers of Attorney
authorizing the person signing this Registration Statement or Amendment to the
Registration Statement to do so on behalf of such members.




                                      R-2

<PAGE>



MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED
   DEPOSITOR


<TABLE>
<S>                                                 <C>
By the following persons, who constitute a          Powers of Attorney have been filed
   majority of the Board of Directors of Merrill    under Form SE and the following
   Lynch, Pierce, Fenner & Smith                    1933 Act File Numbers: 333-70593
   Incorporated:
</TABLE>

      GEORGE A. SCHIEREN
      JOHN L. STEFFENS



By    J. DAVID MEGLEN
      (As authorized signatory for Merrill
      Lynch, Pierce, Fenner & Smith
      Incorporated and Attorney-in-fact for the
      persons listed above)



                                      R-3







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