OXIS INTERNATIONAL INC
8-K/A, 1995-09-29
PHARMACEUTICAL PREPARATIONS
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<PAGE>
 
                       SECURITIES AND EXCHANGE COMMISSION

                            WASHINGTON, D.C.  20549


                                   FORM 8-K/A

                                 CURRENT REPORT

                        Pursuant to Section 13 or 15(d)
                     of the Securities Exchange Act of 1934



                               September 28, 1995
                   (Earliest event reported - July 19, 1995)

                         Commission File Number 0-8092

                            OXIS INTERNATIONAL, INC.
                             A Delaware corporation
                 I.R.S. Employer Identification No. 94-1620407
                        6040 N. Cutter Circle, Suite 317
                              Portland, OR  97217
                           Telephone:  (503) 283-3911
                              FAX:  (503) 283-4058
<PAGE>
 
Item 7.  Financial Statements and Exhibits
- ------------------------------------------

(a) and (b) Financial Statements and Pro Forma Financial Information
            --------------------------------------------------------

     On August 3, 1995, the Company filed a Report on Form 8-K reporting the
     acquisition of Therox Pharmaceuticals, Inc. ("Therox").  The Report on Form
     8-K indicated that additional financial information would be filed under
     cover of a Form 8-K/A report.  The additional financial information is
     provided herewith, as follows.

     .  Audited financial statements of Therox as of, and for the two years
        ended, December 31, 1994.

     .  Unaudited financial statements of Therox as of, and for the three months
        ended March 31, 1995.

     .  Pro forma balance sheets for the two companies combined as of December
        31, 1994 and March 31, 1995.

     .  Pro forma statements of operations for the two companies for the year
        ended December 31, 1994 and for the three months ended March 31, 1995.

(c)  Exhibits
     --------

     Exhibit 99(1) Audited financial statements of Therox as of, and for the two
     years ended, December 31, 1994.

     Exhibit 99(2) Unaudited financial statements of Therox as of, and for the
     three months ended March 31, 1995.

     Exhibit 99(3) Unaudited pro forma financial information including:

     .  A pro forma balance sheet for the two companies combined as of December
        31, 1994.

     .  A pro forma statement of operations for the two companies combined for
        the year ended December 31, 1994.

     .  A pro forma balance sheet for the two companies combined as of March 31,
        1995.

     .  A pro forma statement of operations for the two companies combined for
        the three months ended March 31, 1995.

                                       2
<PAGE>
 
                                   SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

September 28, 1995                  OXIS International, Inc.


                                         s/ Jon S. Pitcher
                                         -----------------------
                                         Jon S. Pitcher
                                         Chief Financial Officer

                                       3
<PAGE>
 
                                 EXHIBIT INDEX
<TABLE>
<CAPTION>
 
                                                                      Page
Exhibit                                                              Number
- -------                                                              ------
<S>                    <C>                                           <C> 
99(1)                  Audited financial statement of                  
                       Therox as of, and for the two                   
                       years ended, December 31, 1994.                  5
                                                                       
99(2)                  Unaudited financial statements                  
                       of Therox as of, and for the three              
                       months ended March 31, 1995.                    14
                                                                       
99(3)                  Unaudited pro forma financial                     
                       information including:                          19
                       .  A pro forma balance sheet for                
                          the two companies combined as                
                          of December 31, 1994.                        
                       .  A pro forma statement of operations          
                          for the two companies combined for           
                          the year ended December 31, 1994.            
                       .  A pro forma balance sheet for the            
                          two companies combined as of                 
                          March 31, 1995.                              
                       .  A pro forma statement of operations          
                          for the two companies combined for           
                          the three months ended March 31, 1995.       
</TABLE> 

                                       4

<PAGE>
 
                                                                   EXHIBIT 99(1)



                         Audited Financial Statements

                         Therox Pharmaceuticals, Inc.

                          December 31, 1994 and 1993

                                       5
<PAGE>
 
             [LETTERHEAD OF BARNA, KOWALL & COMPANY APPEARS HERE]


REPORT OF INDEPENDENT AUDITORS




Board of Directors and Shareholders
Therox Pharmaceuticals, Inc.


We have audited the accompanying balance sheets of Therox Pharmaceuticals, Inc. 
(a development stage enterprise) as of December 31, 1994 and 1993, and the 
related statement of operations, and shareholders' equity and cash flows for the
year ended December 31, 1994 and the period from July 1, 1993 (date of 
inception) to December 31, 1993. These financial statements are the 
responsibility of the Company's management. Our responsibility is to express an 
opinion on these financial statements based on our audits.

We conducted our audits in accordance with generally accepted auditing 
standards. Those standards require that we plan and perform the audit to obtain 
reasonable assurance about whether the financial statements are free of material
misstatement. An audit includes examining on a test basis, evidence supporting 
the amounts and disclosures in the financial statements. An audit also includes 
assessing the accounting principles used and significant estimates made by 
management, as well as evaluating the overall financial statement presentation. 
We believe that our audits provide a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present fairly, in 
all material aspects, the financial position of Therox Pharmaceuticals, Inc. at 
December 31, 1994 and 1993 and the results of its operation and its cash flows 
for the year ended December 31, 1994 and for the period from July 1, 1993 (date 
of inception) to December 31, 1993, in conformity with generally accepted 
accounting principles.



/s/ Barna, Kowall & Company

June 22, 1995

                                       6
<PAGE>
 
THEROX PHARMACEUTICALS, INC.
(A Development Stage Enterprise)

BALANCE SHEETS

<TABLE> 
<CAPTION> 

                                                       December 31,
                                                     1994        1993
                                                  ----------- ----------- 
<S>                                              <C>         <C> 
ASSETS

Current Assets
    Cash                                         $   470,740 $   894,358
    Prepaid expenses                                   5,000

                                                  ----------- ----------- 
                      Total Current Assets           475,740     894,358

Property and Equipment
    Equipment used in research                        21,473       4,208
    Less allowance for depreciation                (   2,989)  (     421)

                                                  ----------- ----------- 
                                                      18,484       3,787
Other assets, net of accumulated amortization
  of $2,250 and $750 in 1994 and 1993
  respectively.                                       12,750      14,250

                                                  ----------- ----------- 
TOTAL ASSETS                                     $   506,974 $   912,395
                                                  =========== ===========


LIABILITIES AND SHAREHOLDERS' EQUITY

Current Liabilities
    Accounts payable                             $   122,918 $     9,176
    Payroll taxes payable                              1,784

                                                  ----------- ----------- 
                 Total Current Liabilities           124,702       9,176


SHAREHOLDERS' EQUITY

    Series A,Preferred stock, $.001 par value:
      Authorized shares- 1,000,000 shares
      Issued and outstanding- 1,000,000 shares         1,000       1,000
      Additional paid-in-capital                     979,000     979,000

    Common stock, $.001 par value:
      Authorized shares- 2,000,000 shares
       (1,000,000 shares at December 31, 1993)
      Issued and outstanding- 283,000 shares             283         283


    Deficit accumulated during development stage   ( 598,011)  (  77,064)

                                                  ----------- ----------- 
                                                     382,272     903,219

                                                  ----------- ----------- 
TOTAL LIABILITIES AND SHAREHOLDERS' EQUITY       $   506,974 $   912,395
                                                  =========== ===========
</TABLE> 
See accompanying notes to financial statements.

                                       7
<PAGE>
 
THEROX PHARMACEUTICALS, INC.
(A Development Stage Enterprise)

STATEMENT OF OPERATIONS

Year Ended December 31, 1994 and for the
Period from July 1, 1993 (Date of Inception)
to December 31, 1993

<TABLE> 
<CAPTION> 

                                                              Cumulative
                                             December 31,        from
                                         1994        1993     July 1,1993
                                      ----------- ----------- -----------
<S>                                 <C>          <C>         <C> 
Research and development expenses   $    526,039 $    66,046 $   592,085
General and administrative expenses       10,530      14,353      24,883

                                      ----------- ----------- ----------- 
Total expenses                           536,569      80,399     616,968

Other income (expense):
  Interest income                         15,622       3,335      18,957

                                      ----------- ----------- ----------- 
Net loss                            $    520,947 $    77,064 $   598,011
                                      =========== =========== ===========
</TABLE> 


See accompanying notes to financial statements.

                                       8
<PAGE>
 
THEROX PHARMACEUTICALS, INC.                   
(A Development Stage Enterprise)     
                                            
STATEMENT OF SHAREHOLDERS' EQUITY       

<TABLE> 
<CAPTION> 
                                           Series A                                                                              
                                           Preferred Stock          Common Stock             Deficit                             
                                           ----------------------   ----------------------   Accumulated                         
                                           Number                   Number                   during      Additional              
                                           of                       of                       Development Paid-In                 
                                           Shares      Amount       Shares      Amount       Stage       Capital     Total       

                                           ----------  ----------   ----------  ----------   ----------  ----------  ----------  
<S>                                        <C>         <C>          <C>         <C>          <C>         <C>         <C>    
Balance July 1, 1993                           ---     $   ---         ---      $   ---      $   ---     $   ---     $   ---     
Issuance of Series A preferred stock,                                                                                            
  net of expense                           1,000,000        1,000                                           979,000      980,000 
Issuance of common stock                                              283,000         283                                    283 
Net loss                                                                                      (   77,064)               ( 77,064)
                                           ----------  ----------   ----------  ----------   ----------- ----------  -----------  
Balance December 31, 1993                  1,000,000        1,000     283,000         283     (   77,064)   979,000      903,219 
Net loss                                                                                      (  520,947)               (520,947)
                                           ----------  ----------   ----------  ----------   ----------- ----------  -----------  
Balance December 31, 1994                  1,000,000   $    1,000     283,000   $     283    $ (598,011) $  979,000  $   382,272 
                                           ==========  ==========   ==========  ==========   =========== =========== =========== 
</TABLE> 
                                                  
                                                            
                                        
See accompanying notes to financial statements.               

                                       9
<PAGE>
 
THEROX PHARMACEUTICALS, INC.
(A Development Stage Enterprise)

STATEMENT OF CASH FLOWS

Year Ended December 31, 1994 and for the
Period from July 1, 1993 (Date of Inception)
to December 31, 1993

<TABLE> 
<CAPTION> 
                                                              Cumulative
                                             December 31,        from
                                         1994        1993     July 1,1993

                                      ----------- ----------- -----------
<S>                                 <C>          <C>         <C> 
OPERATING ACTIVITIES
   Net loss                         $  ( 520,947)$ (  77,064)$ ( 598,011)
   Adjustments to reconcile net
    loss to net cash used by
     operating activities:
    Depreciation                           2,568         421       2,989
    Amortization                           1,500         750       2,250
    (Increase) decrease in:
             Prepaid expenses          (   5,000)              (   5,000)
    Increase (decrease) in:
             Accounts payable            113,742       9,176     122,918
             Payroll taxes payable         1,784                   1,784

                                      ----------- ----------- ----------- 
    NET CASH USED BY
        OPERATING ACTIVITIES           ( 406,353)  (  66,717)  ( 473,070)

INVESTING ACTIVITIES
   Purchase of equipment
      used in research                 (  17,265)  (   4,208)  (  21,473)
   Purchase of intangibles                         (  15,000)  (  15,000)

                                      ----------- ----------- ----------- 
NET CASH (USED) BY
        INVESTING ACTIVITIES           (  17,265)  (  19,208)  (  36,473)

FINANCING ACTIVITIES
   Proceeds from issuance of
     stock, net of expense                     0     980,283     980,283

                                      ----------- ----------- ----------- 
NET CASH PROVIDED BY
        FINANCING ACTIVITIES                   0     980,283     980,283

                                      ----------- ----------- ----------- 
NET INCREASE (DECREASE) IN CASH        ( 423,618)    894,358     470,740

Cash at beginning of year                894,358           0           0

                                      ----------- ----------- ----------- 
CASH AT END OF YEAR                 $    470,740 $   894,358 $   470,740
                                      =========== =========== ===========

Cash paid for interest              $          0 $         0 $         0
                                      =========== =========== ===========
</TABLE> 


See accompanying notes to financial statements.

                                      10
<PAGE>
 
THEROX PHARMACEUTICALS, INC.
(A Development Stage Enterprise)

NOTES TO FINANCIAL STATEMENTS
December 31, 1994 and 1993

NOTE A--SIGNIFICANT ACCOUNTING POLICIES

Background

Therox Pharmaceutical, Inc. (formerly Anti-Ox, Inc.), (the Company), is a
development stage enterprise formed in July 1993 for the purpose of conducting
research and development of new pharmaceutical technology. Upon the discovery of
any new technology, the Company will develop and market the related products.

The Company conducts its research primarily through consultants in conjunction
with several universities under research agreements that permit the Company to
either retain ownership or licensing rights for any discoveries. Accounts
payable include $118,540 of amounts owed under these agreements for research
performed prior to December 31, 1994. The Company is obligated to fund up to an
additional $147,500 under terms of certain research agreements that expire
August 31, 1995. Amounts are subject to completion of the agreed upon research
by the respective university.

The Company has operated as a development stage enterprise since its inception
and has not recognized any operating revenues.

Property and Equipment

Property and equipment are stated at cost. Depreciation is computed using
straight line methods over the estimated useful lives of the assets (five
years).

Other Assets

Other assets consist of amounts paid for a licensing agreement for patented
items. Amortization is computed using the straight line method over the
remaining lives of the patents, (approximately ten to seventeen years).

Employee Benefit Plan

The Company does not sponsor any qualified employee benefit plans or post
employment benefit plans.


NOTE B--CAPITALIZATION

In December 1993 the Company issued 1,000,000 shares of Series A preferred stock
for net consideration of $980,000. Series A preferred stock are convertible to
common, have voting rights and liquidation preferences over common stock, and
has a dividend rate of $.08. Dividends are cumulative, begin to accrue in
December of 1995 and are payable in preferred stock.

In December 1993 the Company issued 283,000 shares of common stock for a
consideration of $283. The Company has reserved 525,000 shares of common stock
for issuance under stock options and 1,000,000 shares for conversion of
preferred stock.

                                      11
<PAGE>
 
THEROX PHARMACEUTICALS, INC.
(A Development Stage Enterprise)

NOTES TO FINANCIAL STATEMENTS
December 31, 1994 and 1993

NOTE C--STOCK OPTION PLAN AND STOCK OPTION AGREEMENT

In 1994, the Company reserved 500,000 shares of common stock for issuance
pursuant to its stock option plan. The Company has granted options to purchase
common stock to certain employees, directors and consultants. As of December 31,
1994 options were granted to purchase 100,000 shares of common stock at $.10 per
share (no options were granted in 1993). No options were exercised in 1994 or
1993.

In February 1994, the Company granted options to purchase 25,000 shares of
common stock to a preferred shareholder, Brantley Venture Partners II, L.P., at
$.01 per share. No options were exercised as of December 31, 1994 under this
agreement.

NOTE D--INCOME TAXES

At December 31, 1994, the Company had net operating loss carryforwards available
to offset future taxable income of approximately $598,011, which expire in the
years 2008 and 2009.

Net operating loss carryforwards for financial reporting purposes and
alternative minimum tax reporting purposes are approximately the same as those
under the regular tax method. Net operating losses may be subject to certain tax
law restrictions in the event of a change in ownership, as defined. The amount
of this restriction, if any, has not been determined.

Deferred income taxes reflect the temporary differences between the carrying
values of assets and liabilities for financial reporting purposes and the
amounts for income tax purposes. The significant components of the Company's
deferred tax assets and liabilities as of December 31, 1994 and 1993 are as
follows:

<TABLE> 
<CAPTION> 
                                                     1994        1993

                                                  ----------- -----------
    <S>                                          <C>         <C> 
    Deferred tax assets:
      Net operating loss carryforwards           $   203,000 $    22,000
      Valuation allowance                          ( 203,000)  (  22,000)

                                                  ----------- -----------
                                                 $    ---    $    ---
                                                  =========== ===========
</TABLE> 

No income taxes were paid in 1994 and 1993.


NOTE E--RELATED PARTY TRANSACTIONS

The president of the Company is also a general partner in Brantley Venture
Partners II, L.P., a principal investor in Series A convertible preferred stock.
The president received no compensation in 1994 and 1993.

                                      12
<PAGE>
 
THEROX PHARMACEUTICALS, INC.
(A Development Stage Enterprise)

NOTES TO FINANCIAL STATEMENTS
December 31, 1994 and 1993

NOTE F--LEASES

The Company incurred lease expense of $1,565 in 1994 and had no lease expense in
1993. The Company has future minimum lease commitments of $2,292 in 1996 and
1997, and $1,337 in 1998.


NOTE G--SUBSEQUENT EVENTS

The Company has signed a letter of intent with OXIS International, Inc. (OXIS),
whereby OXIS would acquire all of the issued and outstanding stock of the
Company in exchange for 1,440,736 shares of OXIS common stock and other
considerations. 

The Company's option holders are permitted to either convert their options to
Company common stock and then exchange the stock for OXIS stock, or exchange the
options for OXIS options.

Subsequent to December 31, 1994, the Company agreed to grant options to purchase
an additional 33,000 shares of common stock at $.10 per share. The Company also
agreed to issue 53,000 shares of common stock as compensation under consulting
and license agreements.

On May 15, 1995 the Company entered into a three year lease agreement (with an
option for an additional year) for laboratory and office space. Rent under the
agreement is $90,000 in the first year, $114,000 in the second year, and
$138,000 in the third year. Concurrent with the lease agreement, the Company
entered into an agreement for services with the landlord for various telephone,
computer, laboratory and waste disposal services. Costs for these services is
calculated on a usage and number of employee basis.

The Company has made arrangements for a $50,000 loan from a principal investor
in Series A convertible preferred stock, S.R. One, Limited, that will be
convertible into approximately 16,250 shares of newly issued Series B
convertible preferred stock at $2.95 per share.

                                      13

<PAGE>
 
                                 EXHIBIT 99(2)

                          THEROX PHARMACEUTICALS, INC.
                        (A Development Stage Enterprise)

                           Balance Sheet (Unaudited)
                                 March 31, 1995

<TABLE>
<S>                                                        <C> 
ASSETS
 
Current assets
 Cash                                                       $343,806
 Prepaid expenses                                                 --
                                                            --------
   Total current assets                                      343,806
 
Property and equipment
 Equipment used in research                                   21,473
 Less allowance for depreciation                              (4,063)
                                                            --------
                                                              17,410
 
Other assets, net of accumulated amortization of $2,625       12,375
                                                            --------
 
   Total assets                                             $373,591
                                                            ========
 
LIABILITIES AND SHAREHOLDERS' EQUITY
 
Current liabilities
 Accounts payable                                          $ 166,985
 Accrued payroll and payroll taxes                             3,940
                                                           ---------
   Total current liabilities                                 170,925
 
Shareholders' equity
 Series A, Preferred stock, $.001 par value:
   Authorized shares - 1,000,000 shares
   Issues and outstanding - 1,000,000 shares                   1,000
   Additional paid-in-capital                                979,000
 Common stock, $.001 par value:
   Authorized shares - 2,000,000 shares
   Issued and outstanding - 283,000 shares                       283
 Deficit accumulated during development stage               (777,617)
                                                           ---------
                                                             202,666
                                                           ---------
 
   Total liabilities and shareholders' equity              $ 373,591
                                                           =========
</TABLE>

                                      14
<PAGE>
 
                          THEROX PHARMACEUTICALS, INC.
                        (A Development Stage Enterprise)

                      Statement of Operations (Unaudited)
              Period Ended March 31, 1995 and for the Period from
               July 1, 1993 (date of inception) to March 31, 1995

<TABLE>
<CAPTION>
 
                                                  Cumulative
                                      March 31,      from
                                        1995     July 1, 1993
                                      ---------  ------------
<S>                                   <C>        <C>
Research and development expenses      $176,722      $768,807
General and administrative expense        5,468        30,351
                                       --------      --------
 
Total expenses                          182,190       799,158
 
Other income (expense)
 Interest income                          2,584        21,541
                                       --------      --------
 
Net loss                               $179,606      $777,617
                                       ========      ========
</TABLE>

                                      15
<PAGE>
 
                          THEROX PHARMACEUTICALS, INC.
                        (A Development Stage Enterprise)

                 Statement of Shareholders' Equity (Unaudited)

<TABLE>
<CAPTION>
 
                                                                 Deficit
                                                               Accumulated
                                            Series A              During    Additional
                                            Preferred  Common  Development   Paid-In
                                              Stock    Stock      Stage      Capital     Total
                                            ---------  ------  -----------  ----------   -----    
<S>                                         <C>        <C>     <C>           <C>       <C>
Balance July 1, 1993                           $   --    $ --    $      --   $     --  $      --
Issuance of 1,000,000 shares
    Series A Preferred Stock,
       net of expense                           1,000      --                 979,000    980,000
Issuance of 283,000 shares                                283                                283
Net loss                                                           (77,064)              (77,064)
                                               ------    ----    ---------   --------  ---------
 
Balance December 31, 1993                       1,000     283      (77,064)   979,000    903,219
Net loss                                                          (520,947)             (520,947)
                                               ------    ----    ---------   --------  ---------
 
Balance December 31, 1994                       1,000     283     (598,011)   979,000    382,272
Net loss                                                          (179,606)             (179,606)
                                               ------    ----    ---------   --------  ---------
 
Balance March 31, 1995                         $1,000    $283    $(777,617)  $979,000  $ 202,666
                                               ======    ====    =========   ========  =========
</TABLE>

                                      16
<PAGE>
 
                          THEROX PHARMACEUTICALS, INC.
                        (A Development Stage Enterprise)

                      Statement of Cash Flows (Unaudited)
              Period Ended March 31, 1995 and for the Period from
               July 1, 1993 (date of inception) to March 31, 1995

<TABLE>
<CAPTION>
 
                                                               Cumulative
                                                  March 31,       from
                                                    1995      July 1, 1993
                                                  ----------  -------------
<S>                                               <C>         <C>
Operating activities
 Net loss                                         $(179,606)     $(777,617)
 Adjustments to reconcile net loss to
   net cash used by operating activities:
   Depreciation                                       1,074          4,063
   Amortization                                         375          2,625
   (Increase) decrease in prepaid expenses            5,000             --
   Increase (decrease) in:
     Accounts payable                                44,067        166,985
     Accrued payroll and taxes                        2,156          3,940
                                                  ---------      ---------
     Net cash used by operating activities         (126,934)      (600,004)
 
Investing activities
 Purchase of equipment used in research                  --        (21,473)
 Purchase of intangibles                                 --        (15,000)
                                                  ---------      ---------
     Net cash (used) by investing activities             --        (36,473)
 
Financing activities
 Proceeds from issuance of stock,
   net of expense                                        --        980,283
                                                  ---------      ---------
     Net cash provided by financing activities           --        980,283
                                                  ---------      ---------
 
Net increase (decrease) in cash                    (126,934)       343,806
 
Cash at beginning of period                         470,740             --
                                                  ---------      ---------
 
Cash at March 31, 1995                            $ 343,806      $ 343,806
                                                  =========      =========
 
Cash paid for interest                                   --             --
                                                  =========      =========
</TABLE>

                                      17
<PAGE>
 
                     CONDENSED NOTE TO FINANCIAL STATEMENTS

The unaudited financial statements do not include all of the information and
notes required by generally accepted accounting principles for complete
financial statements.  All adjustments considered necessary by management for a
fair presentation have been included.  Operating results for interim periods are
not necessarily indicative of the results that may be expected for the full
year.

                                      18

<PAGE>
 
                                 EXHIBIT 99(3)

           OXIS International, Inc. and Therox Pharmaceuticals, Inc.
                   Unaudited Pro Forma Financial Information

On July 19, 1995, OXIS International, Inc. ("OXIS") consummated the acquisition
of Therox pursuant to a transaction wherein Therox was merged with and into a
wholly-owned subsidiary of OXIS.  The unaudited pro forma financial information
presented below combines the balance sheets of OXIS and Therox as of December
31, 1994 and March 31, 1995 and the statements of operations for the year ended
December 31, 1994, and the three months ended March 31, 1995 on a pro forma
basis.  This pro forma combination gives effect to the following assumptions.

 . That the acquisition of Therox by OXIS occurred as of the beginning of each of
  the periods presented.

 . That the Therox acquisition would be accounted for as a purchase.

 . That the purchase price paid by OXIS to acquire Therox will be $3,353,313,
  consisting of 1,440,736 shares of OXIS Common Stock valued at 2.3275 per
  share.  This valuation is based on the average of the closing price of OXIS
  Common Stock from July 14, 1995 through July 20, 1995, the day after the
  consummation of the acquisition, discounted 30% for certain trading
  restrictions and the number of shares of OXIS Common Stock being issued in the
  transaction, as compared to the average trading volume of OXIS Common Stock.

 . That holders of Therox stock options would exercise their options, resulting
  in additional equity for Therox of $68,850, prior to the acquisition.

 . That, simultaneous to the acquisition, the two major Therox shareholders would
  purchase 642,583 shares of OXIS Series B Preferred Stock for an aggregate
  purchase price of $1,500,000.

 . That the excess of the purchase price paid over the shareholders' equity of
  Therox would be allocated entirely to technology for in-process products and
  charged to expense in the first statement of operations for the combined
  companies.

It should be noted that the unaudited pro forma financial information:

 . does not give effect to any costs of combining the companies or to any
  efficiencies in operations that could be achieved by combining the companies,

 . does not purport to be indicative either of the results of operations that
  would have occurred had the acquisition been consummated at the date
  indicated, or of future combined results of operations of the companies.

                                      19
<PAGE>
 
The unaudited pro forma financial information presented below should be read in
conjunction with the notes hereto and the separate financial statements of the
two companies.  Unaudited financial statements of the Company as of June 30,
1995 are included in the Company's second quarter Form 10-Q report filed with
the Securities and Exchange Commission.  Financial statements of Therox as of
December 31, 1994 and March 31, 1995 are included in this report on Form 8-K/A.

                                      20
<PAGE>
 
                     Unaudited Pro Forma Balance Sheet of
                           OXIS International, Inc.
         (OXIS International, Inc., and Therox Pharmaceuticals, Inc.)
                       Combined as of December 31, 1994

<TABLE> 
<CAPTION> 
                                                                 Pro forma          Pro forma
ASSETS                                      OXIS       Therox   adjustments         combined
                                            ----       ------   -----------         --------- 
<S>                                      <C>          <C>       <C>                <C>  
Current assets:
    Cash and cash equivalents            $   936,000  $471,000  $    69,000   (1)  $ 2,976,000
                                                                  1,500,000   (4)
    Certificates of deposit                  496,000                                   496,000
    Accounts receivable                      740,000                                   740,000
    Inventories                              673,000                                   673,000
    Prepaid and other                        228,000     5,000                         233,000
                                         -----------  --------  -----------        -----------  
 
        Total current assets               3,073,000   476,000    1,569,000          5,118,000
                    
 
Property and equipment, net                1,298,000    18,000                       1,316,000
 
Assets under capital leases, net           1,340,000                                 1,340,000
 
Technology for in-process products                                2,902,000   (2)            0
                                                                 (2,902,000)  (3)
Technology for developed products and
    custom assays, net                     5,215,000                                 5,215,000
 
Other assets                                 268,000    13,000                         281,000
                                         -----------  --------  -----------        -----------  
 
        Total assets                     $11,194,000  $507,000  $ 1,569,000        $13,270,000
                                         ===========  ========  ===========        =========== 
</TABLE>

                                      21
<PAGE>
 
                     Unaudited Pro Forma Balance Sheet of
                           OXIS International, Inc.
         (OXIS International, Inc., and Therox Pharmaceuticals, Inc.)
                       Combined as of December 31, 1994
 
LIABILITIES AND SHAREHOLDERS' EQUITY

<TABLE> 
<CAPTION>  
                                                                                       Pro forma                 Pro forma
                                                      OXIS            Therox          adjustments                combined   
                                                      ----            ------          -----------                ---------  
<S>                                                <C>                <C>             <C>                       <C> 
Current liabilities:                                                                                                        
   Note payable to bank                            $   340,000                                                  $    340,000
   Accounts payable                                  1,562,000         $ 123,000                                   1,685,000
   Customer deposits                                 1,116,000                                                     1,116,000
   Accrued liabilities                                 628,000             2,000      $   133,000    (5)             763,000 
   Current portion of capital lease obligations        473,000                                                       473,000
                                                   -----------         ---------      -----------               ------------
                                                                                    
        Total current liabilities                    4,119,000           125,000          133,000                  4,377,000
                                                                                    
Capital lease obligations                              297,000                                                       297,000
                                                                                    
Other liabilities                                       79,000                                                        79,000
                                                                                    
Shareholders' equity:                                                               
    Preferred stock:                                       
        OXIS                                                 0                              6,000    (4)               6,000
        Therox                                                             1,000           (1,000)   (2)                   0
                                                                                    
    Common stock:                                
        OXIS                                         4,661,000                            720,000    (2)           5,381,000
        Therox                                                                 0
                                                                                    
    Additional paid-in capital:                                     
        OXIS                                        20,230,000                          2,633,000    (2)          24,224,000
                                                                                        1,494,000    (4)
                                                                                         (133,000)   (5)
        Therox                                                           979,000           69,000    (1)                   0
                                                                                       (1,048,000)   (2)
    Accumulated deficit:                                     
        OXIS                                       (18,139,000)                        (2,902,000)   (3)         (21,041,000)
        Therox                                                          (598,000)         598,000    (2)                   0
                                                                                    
    Accumulated translation adjustments                (53,000)                                                      (53,000)
                                                   -----------         ---------      -----------               ------------

        Total shareholders' equity                   6,699,000           382,000        1,436,000                  8,517,000
                                                   -----------         ---------      -----------               ------------

            Total liabilities and shareholders'
            equity                                 $11,194,000         $ 507,000      $ 1,569,000               $ 13,270,000
                                                   ===========         =========      ===========               ============
</TABLE>

                                      22
<PAGE>
 
                   Notes to Unaudited Pro Forma Balance Sheet
                               December 31, 1994

1. To reflect cash paid for exercise of Therox stock options prior to the
   acquisition of Therox by OXIS.

2. To reflect the pro forma purchase price, $3,353,313, paid to acquire Therox,
   consisting of 1,440,736 shares of OXIS Common Stock at $2.3275 per share.
   This valuation is based on the average of the closing price of OXIS Common
   Stock from July 14, 1995 through July 20, 1995, the day after the
   consummation of the acquisition, discounted 30% for certain trading
   restrictions and the number of shares of OXIS Common Stock being issued in
   the transaction, as compared to the average trading volume of OXIS Common
   Stock.  The excess of the pro forma purchase price over the shareholders'
   equity of Therox has been allocated entirely to technology for in-process
   products.

   Stock issued in connection with the acquisition has been recorded in
   shareholders' equity as follows:

<TABLE>
 
<S>                                                          <C>
     Common Stock, 1,440,736 shares at $.50 par              $  720,000
     Additional paid-in capital                               2,633,000
                                                             ----------
 
     Stock issued - 1,440,736 shares at $2.3275 per share    $3,353,000
                                                             ==========
</TABLE>

3. The amount allocated to technology on in-process products will be charged to
   expense in the first statement of operations for the combined companies
   inasmuch as these amounts relate to research and development for which there
   is no alternative future use.  Consequently, the unaudited pro forma balance
   sheet has been prepared to present the total assets and shareholders' equity
   immediately following this write off.

4. To reflect $1,500,000 cash paid by the two major Therox shareholders for
   642,583 shares of OXIS Series B Preferred Stock.  The Series B preferred
   Stock is presented as:

<TABLE>
 
<S>                                <C>
     642,583 shares at .01 par     $    6,000
     Additional paid in capital     1,494,000
                                   ----------
 
     Cash paid                     $1,500,000
                                   ==========
</TABLE>

5. To reflect a liability for costs directly attributable to issuance of stock.

6. In addition to the OXIS shares issued, the stockholders of Therox may receive
   up to $2,000,000 based on the successful commercialization of the Therox
   technologies.  No effect has been given in the pro forma balance sheet for
   this matter.

                                      23
<PAGE>
 
                  Unaudited Pro Forma Statement of Operations
                           OXIS International, Inc.
         (OXIS International, Inc., and Therox Pharmaceuticals, Inc.)
                 Combined for the year ended December 31, 1994

<TABLE> 
<CAPTION> 
 
                                                                       Pro forma     Pro forma
                                              OXIS         Therox     adjustments    combined
                                              ----         ------     -----------    ---------  
<S>                                       <C>            <C>          <C>          <C> 
Revenues:
     Sales                                $  3,325,000                             $  3,325,000
     Royalties                                 145,000                                  145,000
                                          ------------   ----------   -----------  ------------
 
        Total revenues                       3,470,000                          0     3,470,000
 
Costs and expenses:
     Cost of sales                           2,074,000                                2,074,000
     Research and development                1,670,000   $  526,000                   2,196,000
     Sales, general and administrative       1,652,000       11,000                   1,663,000
     Purchased in-process technology         3,675,000                                3,675,000
                                          ------------   ----------   -----------  ------------ 
 
        Total costs and expenses             9,071,000      537,000             0     9,608,000
                                          ------------   ----------   -----------  ------------  
 
Operating loss                              (5,601,000)    (537,000)            0    (6,138,000)
 
Interest income                                 82,000       16,000                      98,000
 
Interest expense                               (48,000)                                 (48,000)
                                          ------------   ----------   -----------  ------------ 
 
Net loss                                   ($5,567,000)   ($521,000)           $0   ($6,088,000)
                                          ============   ==========   ===========  ============  

Net loss per OXIS share                         ($0.88)                                  ($0.50)
                                          ============                             ============
</TABLE>

                                      24
<PAGE>
 
              Notes to Unaudited Pro Forma Statement of Operations
                      for the Year Ended December 31, 1994


1. The write off of the pro forma purchase price amount allocated to technology
   on in-process products is not reflected in the unaudited pro forma statement
   of operations.  This amount relates to research and development in process
   for which there is no alternative future use and is expected to approximate
   $2,902,000.  This amount will be written off in the initial period of
   operations of the combined companies.

2. Net loss per OXIS share in the unaudited pro forma statement of operations
   has been computed based upon 12,124,423 Common Shares outstanding upon
   consummation of the acquisition.

                                      25
<PAGE>
 
                     Unaudited Pro Forma Balance Sheet of
                           OXIS International, Inc.
         (OXIS International, Inc., and Therox Pharmaceuticals, Inc.)
                         Combined as of March 31, 1995

<TABLE> 
<CAPTION> 
 
                                                                  Pro forma          Pro forma
ASSETS                                     OXIS       Therox     adjustments         combined
                                           ----       ------     -----------         ---------
<S>                                   <C>             <C>        <C>                <C> 
Current assets:
   Cash and cash equivalents          $   724,000     $344,000   $    69,000  (1)   $ 2,637,000
                                                                   1,500,000  (4)
   Certificates of deposit                198,000                                       198,000
   Accounts receivable                  1,002,000                                     1,002,000
   Inventories                            653,000                                       653,000
   Prepaid and other                      313,000                                       313,000
                                      -----------     --------   -----------        -----------
 
      Total current assets              2,890,000      344,000     1,569,000          4,803,000
                    
 
Property and equipment, net             1,286,000       18,000                        1,304,000
 
Assets under capital leases, net        1,422,000                                     1,422,000
 
Technology for in-process products                                 3,081,000  (2)             0
                                                                  (3,081,000) (3)
Technology for developed products and
   custom assays, net                   5,189,000                                     5,189,000
 
Other assets                              300,000       12,000                          312,000
                                      -----------     --------   -----------        -----------
 
      Total assets                    $11,087,000     $374,000   $ 1,569,000        $13,030,000
                                      ===========     ========   ===========        ===========
</TABLE>

                                      26
<PAGE>
 
                     Unaudited Pro Forma Balance Sheet of
                           OXIS International, Inc.
         (OXIS International, Inc., and Therox Pharmaceuticals, Inc.)
                         Combined as of March 31, 1995
 
LIABILITIES AND SHAREHOLDERS' EQUITY

<TABLE> 
<CAPTION> 
                                                                            Pro forma              Pro forma
                                           OXIS            Therox           adjustments            combined
                                           ----            ------           -----------            ---------  
<S>                                     <C>               <C>               <C>                   <C> 
Current liabilities:                                                                              
   Note payable to bank                 $    198,000                                              $    198,000
   Other notes payable                       766,000                                                   766,000
   Accounts payable                        2,066,000      $ 167,000                                  2,233,000
   Customer deposits                         250,000                                                   250,000
   Accrued liabilities                       661,000          4,000         $   133,000   (5)          798,000
   Current portion of capital lease                                                               
   obligations                               431,000                                                   431,000
                                        ------------       --------         -----------           ------------ 
                                                                                                  
       Total current liabilities           4,372,000        171,000             133,000              4,676,000
                                                                                                  
Capital lease obligations                    267,000                                                   267,000
                                                                                                  
Other liabilities                             76,000                                                    76,000
                                                                                                  
Shareholders' equity:                                                                             
   Preferred stock:                                                                               
       OXIS                                                                       6,000   (4)            6,000
       Therox                                                 1,000              (1,000)  (2)                0
                                                                                                  
   Common stock:                                                                                  
       OXIS                                4,708,000                            720,000   (2)        5,428,000
       Therox                                                     0                               
                                                                                                  
   Additional paid-in capital:                                                                    
       OXIS                               20,338,000                          2,633,000   (2)       24,332,000
                                                                              1,494,000   (4)     
                                                                               (133,000)  (5)     
       Therox                                               979,000              69,000   (1)                0
                                                                             (1,048,000)  (2)     
   Accumulated deficit:                                                                           
       OXIS                              (18,896,000)                        (3,081,000)  (3)      (21,977,000)
       Therox                                              (777,000)            777,000   (2)                0
                                                                                                  
   Accumulated translation adjustments       222,000                                                   222,000
                                        ------------       --------         -----------           ------------ 
                                                                                                  
       Total shareholders' equity          6,372,000        203,000           1,436,000              8,011,000
                                        ------------       --------         -----------           ------------ 
          Total liabilities and                                                                   
          shareholders' equity          $ 11,087,000       $374,000         $ 1,569,000           $ 13,030,000
                                        ============       ========         ===========           ============
</TABLE>

                                      27
<PAGE>
 
                   Notes to Unaudited Pro Forma Balance Sheet
                                 March 31, 1995

1. To reflect cash paid for exercise of Therox stock options prior to the
   acquisition of Therox by OXIS.

2. To reflect the pro forma purchase price, $3,353,313, paid to acquire Therox,
   consisting of 1,440,736 shares of OXIS Common Stock at $2.3275 per share.
   This valuation is based on the average of the closing price of OXIS Common
   Stock from July 14, 1995 through July 20, 1995, the day after the
   consummation of the acquisition, discounted 30% for certain trading
   restrictions and the number of shares of OXIS Common Stock being issued in
   the transaction, as compared to the average trading volume of OXIS Common
   Stock.  The excess of the pro forma purchase price over the shareholders'
   equity of Therox has been allocated entirely to technology for in-process
   products.

   Stock issued in connection with the acquisition has been recorded in
   shareholders' equity as follows:

<TABLE>
 
<S>                                                          <C>
     Common Stock, 1,440,736 shares at $.50 par              $  720,000
     Additional paid-in capital                               2,633,000
                                                             ----------
 
     Stock issued - 1,440,736 shares at $2.3275 per share    $3,353,000
                                                             ==========
</TABLE>

3. The amount allocated to technology on in-process products will be charged to
   expense in the first statement of operations for the combined companies
   inasmuch as these amounts relate to research and development for which there
   is no alternative future use.  Consequently, the unaudited pro forma balance
   sheet has been prepared to present the total assets and shareholders' equity
   immediately following this write off.

4. To reflect $1,500,000 cash paid by the two major Therox shareholders for
   642,583 shares of OXIS Series B Preferred Stock.  The Series B preferred
   Stock is presented as:

<TABLE>
 
<S>                                <C>
     642,583 shares at .01 par     $    6,000
     Additional paid in capital     1,494,000
                                   ----------
 
     Cash paid                     $1,500,000
                                   ==========
</TABLE>

5. To reflect a liability for costs directly attributable to issuance of stock.

6. In addition to the OXIS shares issued, the stockholders of Therox may receive
   up to $2,000,000 based on the successful commercialization of the Therox
   technologies.  No effect has been given in the pro forma balance sheet for
   this matter.

                                      28
<PAGE>
 
                  Unaudited Pro Forma Statement of Operations
                            OXIS International, Inc.
          (OXIS International, Inc., and Therox Pharmaceuticals, Inc.)
               Combined for the three months ended March 31, 1995
 

<TABLE> 
<CAPTION> 
                                                                                
                                                                             Pro forma           Pro forma
                                              OXIS          Therox          adjustments          combined   
                                              ----          ------          -----------          ---------  
<S>                                        <C>            <C>               <C>                  <C> 
Revenues:                                                                                                   
   Sales                                   $2,075,000                                            $2,075,000 
   Royalties                                   51,000                                                51,000 
                                           ----------     ----------        -----------          ---------- 
                                                                                                            
      Total revenues                        2,126,000                                             2,126,000 
                                                                                                            
Costs and expenses:                                                                                         
   Cost of sales                            1,177,000                                             1,177,000 
   Research and development                 1,029,000     $  177,000                              1,206,000  
   Sales, general and administrative          645,000          5,000                                650,000
   Purchased in-process technology                                                                        0
                                           ----------     ----------        -----------          ---------- 

      Total costs and expenses              2,851,000        182,000                              3,033,000
                                           ----------     ----------        -----------          ---------- 
 
Operating loss                               (725,000)      (182,000)                              (907,000)
 
Interest income                                 6,000          2,000                                  8,000
 
Interest expense                              (38,000)                                              (38,000)
                                           ----------     ----------        -----------          ---------- 
 
Net loss                                    ($757,000)     ($180,000)                $0           ($937,000)
                                           ==========     ==========        ===========          ==========  
 
Net loss per OXIS share                        ($0.08)                                               ($0.08)
                                           ==========                                            ==========  
</TABLE>

                                      29
<PAGE>
 
              Notes to Unaudited Pro Forma Statement of Operations
                   for the Three Months Ended March 31, 1995


1. The write off of the pro forma purchase price amount allocated to technology
   on in-process products is not reflected in the unaudited pro forma statement
   of operations.  This amount relates to research and development in process
   for which there is no alternative future use and is expected to approximate
   $3,081,000.  This amount will be written off in the initial period of
   operations of the combined companies.

2. Net loss per OXIS share in the unaudited pro forma statement of operations
   has been computed based upon 12,124,423 Common Shares outstanding upon
   consummation of the acquisition.

                                      30


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