OXIS INTERNATIONAL INC
8-K, 1997-06-02
PHARMACEUTICAL PREPARATIONS
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<PAGE>
 
                      SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, DC 20549


                               ----------------

                                   FORM 8-K

                                CURRENT REPORT
                    PURSUANT TO SECTION 13 OR 15(D) OF THE
                        SECURITIES EXCHANGE ACT OF 1934


       Date of Report (date of earliest event reported)      May 6, 1997
                                                       ------------------------

                            OXIS INTERNATIONAL, INC.
               --------------------------------------------------
               (Exact Name of Registrant as Specified in Charter)



   DELAWARE                      0-8092                        94-1620407
- --------------------------------------------------------------------------------
(STATE OR OTHER         (COMMISSION FILE NUMBER)             (IRS EMPLOYER 
JURISDICTION OF                                          IDENTIFICATION NUMBER)
INCORPORATION)                                                        

6040 N. Cutter Circle, Suite 317, Portland, OR                   97217
- --------------------------------------------------------------------------------
   (ADDRESS OF PRINCIPAL EXECUTIVE OFFICES)                    (ZIP CODE)


Registrant's telephone number, including area code.      (503) 283-3911
                                                    ----------------------------

- --------------------------------------------------------------------------------
         (FORMER NAME OR FORMER ADDRESS, IF CHANGED SINCE LAST REPORT)


                                                    Exhibit Index at page:  6
                                                                          -----
<PAGE>
 
ITEM 5.   OTHER EVENTS
          ------------

         (a) On May 6, 1997 OXIS International, Inc. (the "Company") announced
that it had entered into an agreement with its underwriters whereby 10,000,000
shares of the Company's common stock would be listed on the Paris stock market,
Le Nouveau Marche, no later than May 15, 1997 and that the settlement from the
sale of such shares would close no later than May 20, 1997. The Company will be
the first previously listed U.S. NASDAQ company to also be listed on Le Nouveau
Marche, a Paris based stock exchange specifically designed to meet the needs of
emerging growth companies.


         (b) On May 13, 1996 the Company announced that it reached an agreement
with its underwriter on the price of the shares of its common stock to be sold
on the Nouveau Marche. The announcement stated that the Company had agreed to
sell nine million (9,000,000) shares of its common stock for 41.4 Million French
francs. In addition, the announcement stated that the underwriter has an
over-allotment option to purchase 2.5 million shares within 30 days of the
listing of the offering. (After this announcement the over-allotment purchase 
option was reduced to 1.35 million shares upon the request of the Commission des
Operations de Bourse, the French securities regulatory authority.)

             All of the securities mentioned herein have not been registered
under the Securities Act of 1933, as amended. The foregoing securities may not
be offered or sold in the United States.


             A copy of the press releases with respect to the offering
referenced above and the listing of the Company's common stock on Le Nouveau
Marche are attached as exhibits to this report.


             Certain of the statements made in this report and in the attached
press releases are forward looking statements that are based on current
expectations which involve a number of uncertainties. The events described
herein may not occur in a timely manner, or at all. Accordingly, the Company's
future activities may differ materially from those projected in the forward-
looking statements.

                                      -2-
<PAGE>
 
ITEM 7. FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS
        ------------------------------------------------------------------

         (c)       Exhibits


99.1     Press Release, dated May 6, 1997

99.2     Press Release, dated May 13, 1997

                                      -3-
<PAGE>
 
ITEM 9. SALES OF EQUITY SECURITIES PURSUANT TO REGULATION S
        ---------------------------------------------------

(a)  Date of Sale:  May 20, 1997
     ------------
     Title of Securities Sold:  Common Stock
     ------------------------
     Amount of Securities Sold:  9,000,000 shares
     -------------------------
     
(b)  Principal Underwriters: Credit Lyonnais, 81 Rue de Richelieu, 75002
     ----------------------  Paris, France
     
(c)  Offering Price of Securities (sold for cash): 41.4 Million French francs
     --------------------------------------------
     (4.60 French francs per share)

     Underwriting Discount/Commissions:
     ---------------------------------

              Management fee     2.00%,     828,000 French francs
     
              Underwriting fee   2.50%,   1,035,000 French francs
     
              Placement fee      2.50%,   1,035,000 French francs

(d)  Section of the Securities Act or rule of the Commission under which the
     -----------------------------------------------------------------------
     issuer claimed exemption from registration: Regulation S, Rules 901-904
     ------------------------------------------
     inclusive.
     

   Facts relied upon to make the exemption available include the following:
   -----------------------------------------------------------------------

   .  The issuer is a reporting issuer.

   .  The transaction was an Offshore Transaction as defined in Rule 902.

   .  No directed selling efforts were made in the United States by the issuer,
      a distributor, any of their respective affiliates, or any person acting
      on behalf of the foregoing.

   .  Offering restrictions, as defined in Rule 902, were implemented.

   .  By the terms of the offering, no offer or sale, if made prior to the
      expiration of the 40-day restricted period, may be made to a U.S. Person,
      as defined in Rule 902.

(e)  Not Applicable.

                                      -4-
<PAGE>
 
                                   SIGNATURES


         Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                         OXIS INTERNATIONAL, INC.
                                         (Registrant)


Dated: June 2, 1997                      By:      /s/Jon S. Pitcher
                                                --------------------------------
                                         Name:    Jon S. Pitcher
                                                --------------------------------
                                         Title:   Chief Financial Officer and
                                                --------------------------------
                                                   Vice President
                                                --------------------------------

                                      -5-
<PAGE>
 
                                 EXHIBIT INDEX
                                 -------------

<TABLE> 
<CAPTION> 
                                                               
                                                                   Page Number in   
                                                               Sequentially Numbered
     Exhibit No.                   Description                     Current Report    
     -----------                   -----------                     --------------
     <C>                <S>                                    <C> 
        99.1            Press Release dated May 6, 1997

        99.2            Press Release dated May 13, 1997

</TABLE> 

                                      -6-

<PAGE>
 
                          OXIS INTERNATIONAL ANNOUNCES
                             SHARES TO BE LISTED ON
                       LE NOUVEAU MARCHE BY MAY 15, 1997


May 6, 1997 PARIS -- OXIS International, Inc. (NASDAQ: OXIS) announced today
that it has entered into an agreement with its underwriters whereby 10,000,000
shares of the Company's common stock will be listed on the Paris Stock Market,
Le Nouveau Marche no later than on May 15, 1997.  The settlement from the sale
of such shares will close no later than May 20, 1997.  OXIS will be the first
previously listed U.S. NASDAQ company to be also listed on the Le Nouveau
Marche.

The offering proceeds should allow the Company to advance its lead therapeutic
molecule BXT-51072 into Phase II Clinical Trials and initiate preclinical
studies in a second lead molecule, TX-153, a lipid soluble antioxidant.

OXIS International, Inc. is a drug discovery and diagnostics company focused on
the development of novel therapeutic molecules and supportive technologies to
treat diseases associated with damage from free radicals and reactive oxygen
species (ROS), i.e., diseases of oxidative stress. OXIS' lead therapeutic
molecule, BXT-51072, is a glutathione peroxidase mimic that completed Phase I
trials and for which OXIS filed an IND for inflammatory bowel diseases in 1996.
A second advanced molecule, TX-153, is a lipid soluble antioxidant that protects
cell membranes from damage from free radicals and ROS.  OXIS is headquartered in
Portland, Oregon, with a French subsidiary, OXIS International, S.A., located
outside of Paris.

All securities mentioned in this press release have not been registered under
the Securities Act of 1933, as amended.  The foregoing securities may not be
offered and sold in the United States, absent registration under the Securities
Act or an applicable exemption from such registration requirements.

Certain of the statements contained in this press release are forward-looking
statements that are based on current expectations which involve a number of
uncertainties, including the company's ability to enter the Le Nouveau Marche
stock market and to further advance the Company's products.  The events
described herein may not occur in a timely manner, or at all. Accordingly, the
company's future activities may differ materially from those projected in the
forward-looking statements.


<PAGE>
 
                    OXIS INTERNATIONAL ANNOUNCES LE NOUVEAU
                             MARCHE OFFERING PRICED



     PARIS -- May 13, 1997 -- OXIS International, Inc. (NASDAQ: OXIS) announced
today that it has reached an agreement with its underwriter on the price of the
OXIS shares of common stock to be sold in its European public offering.  The
Company has agreed to sell 9,000,000 shares of the Company's common stock for
41.4 million French francs (currently equal to approximately US$7.2 million).
In addition, the underwriter has an over allotment option to purchase 2.5
million shares within 30 days of the listing of the offering.  The offering will
make OXIS International, Inc. the first US NASDAQ National Market company to be
also listed on France's Nouveau Marche.  The listing is to be completed by May
15, 1997.

     OXIS International, Inc. is a drug discovery and diagnostics company
focused on the development of novel therapeutic molecules and supportive
technologies to treat diseases associated with damage from free radicals and
reactive oxygen species (ROS), i.e., diseases of oxidative stress.  OXIS' lead
therapeutic molecule, BXT-51072, is a glutathione peroxidase mimic targeted for
inflammatory bowel diseases which will enter Phase II trials in mid 1997.

     All securities mentioned in this press release have not been, and will not
be, registered under the Securities Act of 1933, as amended.  The foregoing
securities may not be offered or sold in the United States, absent registration
under the Securities Act or an applicable exemption from such registration
requirements.

     Certain of the statements contained in this press release are forward-
looking statements that are based on current expectations which involve a number
of uncertainties, including the Company's ability to enter the Le Nouveau Marche
stock market and to further advance the Company's products.  The events
described herein may not occur in a timely manner, or at all.  Accordingly, the
Company's future activities may differ materially from those projected in the
forward-looking statements.



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