OXIS INTERNATIONAL INC
10-K, 1997-03-31
PHARMACEUTICAL PREPARATIONS
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<PAGE>
 
                                    PART I

ITEM 1.    BUSINESS.


INTRODUCTION

     Certain of the statements contained in this report are forward-looking 
     statements based on current expectations which involve a number of 
     uncertainties. The events described herein may not occur due to risks
     inherent in research and product development, the uncertainty of market
     acceptance of Company products, the possible inability to obtain financing,
     and other factors. Accordingly, the Company's future activities may differ
     materially from those projected in the forward-looking statements.

     OXIS International, Inc., (the "Company"), a Delaware corporation, is a
     leader in the discovery, development and commercialization of therapeutic
     and diagnostic products to diagnose, treat and prevent diseases of
     oxidative stress. Oxidative stress occurs when the concentration of free
     radicals and reactive oxygen species ("ROS"), highly reactive molecules
     produced during oxidative processes, exceed the body's antioxidant defense
     mechanisms.

     The Company consists of two closely related operating units: an
     international diagnostic business which markets research and commercial
     diagnostic assays and fine chemicals to research and clinical laboratories;
     and a drug discovery business focused on new drugs to treat diseases
     associated with tissue damage from free radicals and reactive oxygen
     species.


     The Company has targeted its drug discovery and development programs to
     address diseases that have underlying pathologies based on oxidative
     stress, and for which there is currently no optimum treatment. The Company
     has identified lead molecules from two series of small molecular weight
     antioxidants. The first of these lead molecules has completed Phase I
     clinical trials, and the second is in preclinical development. In addition,
     the Company is developing a series of earlier stage compounds for the
     treatment of cancer.

     The Company derives current business revenues from its diagnostic assays
     and two fine chemicals, ergothioneine and bovine superoxide dismutase
     ("bSOD"). The Company's diagnostic products portfolio includes fourteen
     commercial therapeutic drug monitoring ("TDM") assays based on fluorescence
     polarization immunoassay technology ("FPIA"); twelve drugs of abuse assays
     which utilize an enzyme-multiplied immunoassay technique ("EMIT"); and six
     assays to measure oxidative stress.

     The Company's twelve FDA-cleared therapeutic drug monitoring ("TDM") assays
     are sold to clinical and reference laboratories, primarily through a
     network of international distributors. The assays for markers of oxidative
     stress are sold through international distribution and catalog sales to
     basic researchers and clinicians working in oxidative stress research. The
     Company's TDM assays are designed to run on Abbott's TDx(R) and TDx/FLx(R)
     instruments, while the enzyme immunoassays and colorimetric assays run on a
     variety of commercially available instruments.

                                       1
<PAGE>
 
     The Company has invested significant resources to build an early and
     substantial patent position on both its antioxidant therapeutic
     technologies and selected oxidative stress assays.

     The Company's corporate offices are located in a 15,000 sq. ft. facility at
     6040 N. Cutter Circle, Suite 317, Portland, OR 97217. Research operations
     of the Company are located outside of Paris at Z.A. des Petits Carreaux, 2,
     av. des Coquelicots, 94385 Bonneuil-Sur-Marne, Cedex, France.


ACQUISITIONS/MERGERS

     In September 1994, the Company acquired Bioxytech S.A. located in Paris,
     France, and merged with International BioClinical, Inc. ("IBC"), an Oregon
     corporation, and changed its name from DDI Pharmaceuticals, Inc. to OXIS
     International, Inc. Bioxytech S.A. was subsequently renamed OXIS
     International S.A. ("OXIS S.A."). At the time of the acquisition, OXIS
     S.A.'s research and development programs were focused on the synthesis of
     novel antioxidant therapeutic molecules and assays to measure markers of
     oxidative stress. OXIS S.A. was also selling six research assays for
     measuring specific markers of oxidative stress. IBC was selling thirteen
     therapeutic drug monitoring ("TDM") assays at the time of its acquisition
     by the Company. It was also developing one additional TDM assay and a
     (beta)-lactamase rapid detection test, both of which were completed during
     1995.

     In July 1995, OXIS acquired Therox Pharmaceuticals, Inc. ("Therox"), a
     Delaware corporation, through an exchange of stock. Therox was merged into
     a subsidiary of the Company. Therox was founded in 1994 by S.R. One,
     Limited (the venture investment arm of SmithKline Beecham) and Brantley
     Venture Partners II, L.P. Therox was focused on the development of membrane
     active antioxidants and molecules that combine antioxidant activity with
     other key therapeutic effects. The acquisition provided the Company with
     complimentary therapeutic technologies, seven patents and several
     relationships with university scientists.

     Prior to the acquisitions of Bioxytech S.A. and International BioClinical,
     Inc. in 1994, substantially all of the Company's research and development
     efforts involved superoxide dismutase ("SOD") and poly-ethylene glycol
     ("PEG"). The 1994 and 1995 acquisitions substantially expanded the
     Company's research and development capabilities in the areas of synthetic
     chemistry, biochemistry and diagnostic assay development.


RESEARCH AND DEVELOPMENT

     The Company's research and development programs are focused primarily on
     the discovery and development of new therapeutic molecules to combat
     diseases related to damage from oxidative stress. OXIS believes that the
     control or elimination of oxidative stress represents an important but
     largely untapped area for drug development. The Company's technical

                                       2
<PAGE>
 
     approach is to supplement the natural defense systems through unique,
     synthetic molecules which, because of their pharmacological and/or
     distribution properties, will reduce oxidative stress in target cells and
     tissues.

     The Company has designed and synthesized several series of novel compounds,
     including: low-molecular-weight biomimetic antioxidants (Glutathione
     Peroxidase Mimics Program) and pro-oxidants (Cancer Therapeutics Program)
     that are based on unique selenium chemistry; and lipid soluble antioxidants
     and combination enzyme inhibitors/lipid soluble antioxidants (Lipid Soluble
     Antioxidants Program). OXIS has demonstrated that certain of its
     therapeutic molecules may act via two mechanisms to reduce oxidative stress
     in cells: through direct control of oxidative damage; and by decreasing
     specific signals that trigger the inflammatory cycle. Both of the Company's
     lead therapeutic molecules have been shown to inhibit levels of
     NF-(kappa)B, a transcription factor believed to be activated by elevated
     concentrations of ROS. NF-(kappa)B is known to activate genes involved in
     initiating the inflammatory response. The Company believes that the control
     of ROS, and associated decreases in NF-(kappa)B activation, will block the
     initiation of the inflammatory response earlier in the cycle than most
     drugs currently used to treat certain complex inflammatory diseases.

     A brief summary of the Company's synthetic therapeutics research and
     development programs follows:

     GLUTATHIONE PEROXIDASE MIMICS PROGRAM (GPX). The GPx mimics are small
     molecular weight, orally bioavailable compounds that were designed to
     catalyze the inactivation of toxic hydroperoxides. These molecules act as
     chemical catalysts. The lead molecule, BXT-51072, has demonstrated
     significant protection of endothelial cells from direct peroxidase damage
     and down regulates various inflammatory mediators and neutrophil adhesion.
     An oral formulation of BXT-51072 is being developed for the treatment of
     Inflammatory Bowel Disease ("IBD"), with Acute Respiratory Distress
     Syndrome ("ARDS") projected to be a secondary indication for the
     intravenous formulation of the drug. BXT-51072 has demonstrated activity in
     animal models of IBD, and in a porcine model of restenosis. A Phase I
     clinical trial was just completed at the end of 1996 and an investigational
     new drug application has been filed with the Food and Drug Administration
     (the "FDA") for a Phase II study in patients with IBD. This trial is
     expected to begin in mid-1997.

     A patent on this class of compounds has been issued in France and patent
     applications are pending in the United States, Japan, Canada, Australia and
     Europe.

     LIPID SOLUBLE ANTIOXIDANTS PROGRAM (LSA). The LSA compounds were designed
     to combine the antioxidant capabilities of ascorbic acid with the
     membrane-protecting effects of vitamin E. The lead molecule from this
     series, TX-153, has also shown significant protection of endothelial cells
     from direct peroxide damage, and, like BXT-51072, suppresses various
     inflammatory mediators and reduces neutrophil adhesion. Although TX-153
     apparently acts to control ROS in cells through a different pathway than
     the GPx mimics, it also appears to inhibit NF-(kappa)B. 

                                       3
<PAGE>
 
     TX-153 is entering preclinical toxicology studies, with Phase I clinical
     studies anticipated to begin in 1998.

     The Company has four issued U.S. patents, and patent applications pending
     in the United States, Mexico, Japan, Canada and Europe on these compounds.

     CANCER THERAPEUTICS PROGRAM. The Company has designed compounds which
     utilize the destructive nature of free radicals to treat hormone-dependent
     cancers by selectively killing tumor cells by activating ROS.
     Hormone-dependent cancers such as breast and prostate cancer were chosen as
     potential indications for this series of molecules due to the specific
     hormone receptors on their cell membranes. Molecules that mimic the enzyme
     glutathione oxidase have been synthesized, and two strategies are being
     investigated to deliver the molecules to tumor cells and initiate the
     production of ROS inside these cells. Specific steroid molecules are being
     tested for their ability to target tumor cells, and a prodrug approach is
     being used to provide a source of ROS that can be turned on inside the
     cell. A lead molecule has not yet been selected for this series. The
     indications for this series of drugs include breast and prostate cancer,
     but the approach may also be applicable to other tumors.

     The Company has filed patent applications on this series of pro-oxidant
     molecules in the United States and France.

     In addition to its research and development programs in synthetic
     antioxidants, OXIS also has conducted research programs in the development
     of oxidative stress assays, bovine superoxide dismutase and poly-ethylene
     glycol technology. The status of these programs are as follows:

     OXIDATIVE STRESS ASSAYS. The Company has developed six research assay kits
     for markers of oxidative stress that are designed to ultimately facilitate
     diagnosis and optimize therapy of free radical-associated diseases. These
     assays also provide developmental synergy for the pharmaceutical research
     and development programs by facilitating the assessment of oxidative stress
     in laboratory studies and in patients. The Company intends to develop
     additional assays for key markers of oxidative stress as part of its
     ongoing research and development efforts in oxidative stress diagnostics.

     BOVINE SUPEROXIDE DISMUTASE (BSOD). The Company also has extensive
     experience in developing, manufacturing and marketing bovine superoxide
     dismutase ("bSOD"). Bovine superoxide dismutase has been previously studied
     in numerous clinical trials by OXIS and other companies. OXIS is not
     currently pursuing an active research program in bSOD, but supplies bulk
     bSOD for human use and sells an injectable dosage form of the drug for
     veterinary applications under the registered trademark Palosein(R).

     POLY-ETHYLENE GLYCOL TECHNOLOGY (PEG). Additionally, the Company has
     developed a patented, high-molecular weight PEG technology that extends the
     half-life of SOD and other therapeutic proteins. These derivatives reduce
     the immunogenicity of and extend the life of 

                                       4
<PAGE>
 
     therapeutic proteins in the body . (The Company's PEG has been shown to
     extend the life of its bSOD in vivo by 250 times.) The Company has four
     issued U.S. patents as well as numerous issued patents world-wide on this
     technology. The Company is not currently pursuing an active research
     program in PEG technology, but is seeking potential partners for this
     technology for possible license or sale.

     Overall, the Company has an extensive portfolio of patents that cover its
     synthetic antioxidant therapeutic molecules, superoxide dismutase,
     polyethylene glycol technology, markers of oxidative stress and fine
     chemicals. The Company currently holds fifteen U.S. patents and eight
     French patents and has filed for eight additional U.S. patents.

     The Company's overall research and development strategy is to discover and
     advance its therapeutic molecules through early stage clinical trials to
     demonstrate efficacy in the target disease populations. The Company expects
     to seek strategic pharmaceutical partners for later stage clinical
     development and commercialization of its therapeutics, but, to date, has
     not entered into any such partnership.

     Much of the Company's success depends on its potential products which are
     in research and development and from which no material revenues have yet
     been generated. The Company must sucessfully partner, develop, obtain
     regulatory approval for and market or sell its potential therapeutic 
     products to achieve profitable operations. No assurances can be given that
     the Company's product development efforts will be successfully completed,
     that required regulatory approvals will be obtained, or that any such
     products, if developed and introduced will be successfully marketed.
     Competition in the pharmaceutical industry is intense, and no assurances
     can be given that OXIS' competitors will not develop technologies and
     products that are more effective than those being developed by OXIS.

          Research and development expenses were $4,908,000, $4,299,000 and
     $1,670,000 for the years ended December 31, 1996, 1995 and 1994,
     respectively.


PRODUCTS

DIAGNOSTIC ASSAYS

     Revenues from sales of the Company's assays comprised 49% of 1996 revenues,
     and 44% of 1995 revenues.

OXIDATIVE STRESS ASSAYS

     The Company has six research assays available for sale which measure key
     markers in free radical biochemistry (markers of oxidative stress).
     Specifically, these assays measure levels of antioxidant protection,
     oxidative alterations, and pro-oxidant activation of specific white blood
     cells. OXIS' research assays include:

                           SOD-525 (superoxide dismutase)
                           GSH-400 (reduced glutathione)
                           pl-GPx-EIA (human plasma-specific glutathione
                            peroxidase)
                           LPO-586 (lipid peroxidation)
                           MPO-EIA (human myeloperoxidase) 
                           Lactoferrin-EIA (human lactoferrin).

     These assay kits utilize either chemical (colorimetric) or immunoenzymatic
     (EIA) reactions that can be read using laboratory spectrophotometers and
     microplate readers, respectively. The

                                       5
<PAGE>
 
     Company's assays offer advantages over conventional laboratory methods,
     including ease of use, speed, specificity and accuracy.

     The assays for markers of oxidative stress are currently being sold to
     researchers in Europe, Japan and the United States, primarily through
     distributors. The Company estimates that there are more than 3,500
     scientists and clinicians who are working directly in research on free
     radical biochemistry, and who are potential customers for these research
     assays.

     Through June 1996, assays for markers of oxidative stress were manufactured
     at the Company's facility in France. Since July 1996, these assays have
     been manufactured at the Company's facility in Portland, Oregon. All of the
     oxidative stress assays are manufactured in batches in anticipation of
     customer orders. Orders are generally filled within a few days; therefore,
     the Company does not have any significant backlog of orders. The Company
     believes that adequate supplies of raw materials are either currently on
     hand, available from commercial suppliers or available through development
     on a custom basis by commercial contractors, as needed.

     The Company's assays for markers of oxidative stress are protected by trade
     secrets and patents. Seven French patent applications have been filed with
     respect to these assays, two of which have resulted in the issuance of
     patents. The oxidative stress assays are sold under the registered
     trademark "Bioxytech(R)".

     Several companies other than OXIS have developed assays for markers of
     oxidative stress. One company offers assays for superoxide dismutase and
     glutathione peroxidase which compete directly with the Company's products;
     and a few competitive assays for lipid peroxidation are available from
     selected companies. The Company believes that the number and range of its
     assay kits for markers of oxidative stress is a distinct competitive
     advantage.

THERAPEUTIC DRUG MONITORING (TDM) ASSAYS

     The Company sells fourteen TDM assays which are based on FPIA technology.
     These products are sold under the trade name INNOFLUOR(TM). The Company's
     test menu encompasses approximately 90% of the TDM tests performed by
     clinical and reference laboratories worldwide. These assays are designed
     for use on the Abbott Laboratories TDx(R) and TDx/FLx(R) analyzers.

     The TDM products are sold through a combination of direct customer sales
     and distributors in the United States, and through a network of
     distributors outside the United States, principally in Europe.

     The TDM assays are manufactured at the Company's facility in Portland,
     Oregon. All of the TDM assays are manufactured in batches in anticipation
     of customer orders. Orders are generally filled within a few days;
     therefore, the Company does not have any significant backlog of orders. The
     Company believes that adequate supplies of raw materials are either
     

                                       6
<PAGE>
 
     currently on hand, available from commercial suppliers or available through
     development on a custom basis by commercial contractors as needed.

     The Company has one pending U.S. patent application, in addition to relying
     on trade secrets, know-how and trademark laws to protect its TDM assays.
     The Company's TDM assays have been sold under the trade name INNOFLUOR(TM)
     since the mid-1980s.

     Six major diagnostic companies dominate the therapeutic drug monitoring
     market. Each of these six companies provides a range of both
     instrumentation and assays to clinical laboratories. Of these, Abbott
     Laboratories holds the largest market share. OXIS competes most directly
     with Abbott Laboratories, because OXIS' assays are designed to be run on
     Abbott's analyzers. The Company competes based on high product quality, an
     aggressive pricing strategy and technical services. Abbott Laboratories and
     certain of the Company's other competitors have substantially greater
     financial and other resources than the Company and there can be no
     assurances that the Company can effectively compete with Abbott
     Laboratories and such other competitors.

THERAPEUTIC PRODUCTS

     Revenues from sales of bulk bSOD, royalties on bSOD products sold by
     licensees, and sales of Palosein(R), the Company's veterinary bSOD product,
     comprised approximately 50% of the Company's total revenues in 1996, 48% in
     1995 and 76% in 1994.

BOVINE SOD (BSOD) PRODUCTS

     Commercial-scale manufacture and quality control of bulk bSOD, as well as
     subsequent quality control and processing of United States Department of
     Agriculture-inspected edible beef liver into highly purified bulk bSOD
     requires a complex, multi-step process, OXIS has significant knowledge
     regarding the manufacture of bSOD that is protected through trade secrets
     and proprietary know-how.

     The Company has an agreement with Diosynth B.V., a Dutch contract
     manufacturer of pharmaceutical ingredients, to manufacture bulk bSOD and
     supply it to OXIS under the terms of a license based on the Company's
     processes. Diosynth B.V. is an affiliate of AKZO-Nobel N.V., a large, Dutch
     multinational chemical and health care company. The Company believes that
     its present source of bSOD is adequate for its near-term foreseeable needs.

     With the exception of recently developed, patent protected long-acting SOD
     derivatives, the Company's older patents protecting the manufacture of bSOD
     have expired. Expiration of the Company's patents may enable other
     companies to benefit from research and development efforts of the Company,
     but such other companies would not receive the benefits of the Company's
     unpatented trade secrets and know-how or unpublished preclinical or
     clinical data. Such Companies would still be required to expend
     considerable resources to conduct preclinical 

                                       7
<PAGE>
 
     and clinical studies of their own pharmaceutical preparations of SOD to
     gain regulatory approval.

     The Company sells bulk bSOD for human use, but does not market dosage forms
     of bSOD for human use. Palosein(R) is OXIS' registered trademark for its
     veterinary brand of bSOD. Although there are other sources of bSOD and
     other laboratory and pilot-scale processes to produce bSOD, the Company
     believes that it is the only company manufacturing bSOD on a commercial
     scale for pharmaceutical uses.

     The Company's Spanish licensee, Tedec-Meiji Farma, S.A., which distributes
     bSOD for human use in Spain, has been responsible for a substantial portion
     of the Company's revenues in recent years. Sales of bSOD to Tedec-Meiji
     were 39% of the Company's revenues in 1996, 16% in 1995 and 18% in 1994.


EMPLOYEES

     As of December 31, 1996, the Company had 51 employees (30 in the United
     States and 21 in France). Employees of the Company's French subsidiary are
     covered by a government-sponsored collective bargaining agreement. None of
     the United States employees are subject to a collective bargaining
     agreement. The Company has never experienced a work interruption.


FOREIGN OPERATIONS AND EXPORT SALES

     For information regarding the Company's foreign operations and export
     sales, see Note 10 to the consolidated financial statements.


ITEM 2.    PROPERTIES.

     The Company occupies, pursuant to leases, office and laboratory space in
     Portland, Oregon and near Paris, France.

     The Company's Portland, Oregon lease expires in 1997; the lease of the
     facility in France expires in 1998. 

     Although the premises currently occupied are suitable for the Company's
     present requirements, other equally suitable premises are readily
     available.

                                       8
<PAGE>
 
ITEM 3.    LEGAL PROCEEDINGS.

     There are no material legal proceedings to which the Company is a party or
     to which any of its property is subject.


ITEM 4.    SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS.

     No matters were submitted to a vote of security holders of the Company
     during the fourth quarter of the year ended December 31, 1996.




                                    PART II


ITEM 5.    MARKET FOR REGISTRANT'S COMMON STOCK AND RELATED SHAREHOLDER MATTERS.

     The Company's common stock is traded on the NASDAQ National Market System
using the symbol OXIS.

     Recent quarterly prices of the Company's common stock are as follows:
<TABLE>
<CAPTION>

                                 1996                                     1995
                                 ----                                     ----
               
                  4TH       3RD      2ND       1ST         4TH        3RD      2ND      1ST
<S>               <C>       <C>      <C>       <C>         <C>        <C>      <C>      <C>
         High     1 25/32   2 1/8    2 11/16   2           2 13/16    3 1/2    4 1/2    2 7/8

         Low      1 7/32    1 1/2    1 7/16    1 1/2       1 1/8      2 1/4    1 3/4    1 5/8
</TABLE>

     The Company has an estimated 7,800 shareholders, including approximately
     3,500 shareholders who have shares in the names of their stockbrokers. The
     Company utilizes its assets to develop its business and, consequently, has
     never paid a dividend and does not expect to pay dividends in the
     foreseeable future.

                                       9
<PAGE>
 
ITEM 6.   SELECTED FINANCIAL DATA.
<TABLE>
<CAPTION>
     FOR YEARS ENDED
       DECEMBER 31:                   1996              1995                1994              1993             1992
<S>                                 <C>                <C>                 <C>               <C>               <C>    
       Total Revenues1/             $ 4,867,000        $ 5,136,000         $ 3,470,000       $ 3,044,000       $2,772,000
                     --

       Net income (loss)            $(5,992,000)       $(8,892,000)2/      $(5,567,000)3/    $(1,485,000)4/    $ (339,000)
                                                                   --                  --                --

       Net income (loss)
         per share                  $      (.47)       $      (.82)2/      $      (.88)3/    $      (.30)4/    $     (.07)
                                                                   --                  --                --
</TABLE>
<TABLE>
<CAPTION>
     AS OF DECEMBER 31:                    1996               1995                1994              1993             1992
<S>                                 <C>                <C>                 <C>                <C>              <C>    

       Total assets                 $ 7,997,000        $ 9,870,000         $11,194,000        $3,124,000        $4,864,000

       Long-term
         obligations                $     2,000        $ 1,332,000         $   376,000                --               --

       Common shares
         outstanding                 13,790,736         12,124,423           9,322,762         4,982,670         4,982,670
</TABLE>

     1/ Earned interest not included in revenue.
     2/ Includes a charge of $3,329,000 ($.31 per share) for the write off of
     certain technology of an acquired company.
     3/  Includes a charge of $3,675,000 ($.58 per share) for the write off of
     certain technology of acquired companies.
     4/ Includes a charge of $1,531,000 ($.31 per share) for control contest
     expense.

     As explained under the caption "ACQUISITIONS" in Management's Discussion
     and Analysis of Financial Condition and Results of Operations below, the
     Company made significant acquisitions during 1994 and 1995 that affect the
     comparability of the amounts reflected in the table above.


ITEM 7.    MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND
           RESULTS OF OPERATIONS.

ACQUISITIONS

     In September 1994, the Company significantly increased its scientific and
     technical staff, patent application portfolio, current product offerings,
     research and development programs, research and manufacturing facilities
     and its customer base by acquiring Bioxytech S.A. (now "OXIS S.A.") and
     International BioClinical, Inc. ("IBC") (together the "1994 acquired
     businesses"). Both acquisitions were completed through the exchange of
     stock, and were accounted for as purchases; accordingly, the acquired
     assets and liabilities were recorded at 

                                       10
<PAGE>
 
     their estimated fair values as of the date of acquisition. IBC was merged
     into the Company. OXIS S.A. operates as a subsidiary of the Company.

     In July 1995, in a transaction which was also accounted for as a purchase,
     the Company acquired Therox Pharmaceuticals, Inc. ("Therox") through an
     exchange of stock. Therox was merged into a wholly-owned subsidiary of the
     Company. The acquisition of Therox provided the Company with a technology
     portfolio complementary to its novel therapeutics for treatment of free
     radical associated diseases together with university relationships and
     seven patents.

     Because the acquisitions have been accounted for as purchases, the
     Company's consolidated results of operations include the operating results
     of the acquired businesses from the dates of acquisition only. Therefore,
     the results of operations of the 1994 acquired businesses are included in
     the consolidated statements of operations from September 7, 1994, and the
     results of Therox's operations are included in the consolidated statements
     of operations from July 19, 1995.

     Costs relating to the acquisitions and the Company's more complex corporate
     structure and the increased research and development investments have
     placed significant demand on the Company's limited financial resources. See
     "Financial Condition, Liquidity and Capital Resources" below.


FINANCIAL CONDITION, LIQUIDITY AND CAPITAL RESOURCES

     During 1996 the Company's working capital deficit decreased slightly from
     $1,469,000 at December 31, 1995, to $1,405,000 at December 31, 1996. This
     decrease in the Company's working capital deficit resulted primarily from
     the effect of the net loss for 1996 ($5,992,000 less non-cash charges of 
     $1,381,000), offset by proceeds from issuance of stock ($4,305,000) and
     convertible term notes ($1,000,000).

     Cash and cash equivalents declined from $727,000 at December 31, 1995, to
     $422,000 at December 31, 1996.

     The Company expects to continue to report losses in 1997 as the level of
     expenses is expected to continue to exceed revenues. The Company can give
     no assurances as to when and if its revenues will exceed its expenses. The
     Company must raise additional capital during the first half of 1997.
     Failure to raise such additional capital would cause the Company to
     severely curtail or cease operations. For more information concerning the
     Company's ability to continue as a going concern, see Note 1 to the
     consolidated financial statements.

     While the Company believes that its new products and technologies show
     considerable promise, its ability to realize significant revenues therefrom
     is dependent upon the Company's success in developing business alliances
     with biotechnology and/or

                                       11
<PAGE>
 
     pharmaceutical companies that have the required resources to develop and
     market certain of these products. There is no assurance that the Company's
     effort to develop such business alliances will be successful. Although the
     Company is currently seeking additional capital (described below), it
     cannot predict the source, terms, amount, form, and/or availability of
     additional capital to fund its operations to the end of the current year.

     During 1996, the Company raised approximately $5,300,000 cash through the
     sale of its Series C, Series D and Series E Preferred Stock and common
     stock, and convertible term notes. Substantial additional capital will be
     required during 1997 to continue operating in accordance with its current
     plans. The Company has engaged an agent to assist on a best-efforts basis
     to complete a private placement of its common stock. In addition, the
     Company has engaged a French investment banker to act as its underwriter
     for a planned public offering of its common stock on the newly opened
     French stock market, Le Nouveau Marche, subject to obtaining appropriate
     authorization from the French stock market regulatory authorities. However,
     no assurances can be given that the Company will successfully raise the
     needed capital. If the Company is unable to raise additional capital during
     the first half of 1997, it would endeavor to extend its ability to continue
     in business through the reduction of personnel and facility costs, by
     slowing its research and development efforts, and by reducing other
     operating costs, however, no assurances can be given that it will be able
     to do so.


RESULTS OF OPERATIONS

REVENUES

     The Company's sales for the past three years consisted of the following:
<TABLE>
<CAPTION>
                                                1996              1995              1994
<S>                                           <C>              <C>               <C>    
     Diagnostic and research assays           $2,364,000       $2,240,000        $  645,000
     Bovine superoxide dismutase (bSOD)
         for research and human use            1,935,000        1,817,000         2,130,000
     Palosein/(R)/(bSOD for veterinary use)      480,000          555,000           346,000
     Other                                        23,000          370,000           204,000
                                              ----------       ----------        ----------
         Total sales                          $4,802,000       $4,982,000        $3,325,000
                                              ==========       ==========        ==========
</TABLE>

     Diagnostic and research assays are products acquired with the acquisitions
     of IBC and OXIS S.A. Sales of these products for 1994 represent sales from
     September 8 through the end of the year. The entire years' sales of
     diagnostic and research assays are included in the Company's sales for 1995
     and 1996.

     Bulk bSOD sales in 1994 and 1995 included sales to Sanofi Winthrop, Inc.
     Sales of bulk bSOD to Sanofi Winthrop ceased in 1995, when Sanofi Winthrop
     announced that the clinical trial in which it was using the Company's bSOD
     failed to show the desired results. The 

                                       12
<PAGE>
 
     decline in sales to Sanofi Winthrop has been offset to a large extent by
     increases in sales of bSOD to Tedec-Meiji Farma S.A., the Company's Spanish
     licensee.

     Future sales of bulk bSOD are largely dependent on the needs of the
     Company's Spanish licensee. The Company expects its orders for 1997 from
     the Spanish licensee to be less than those for 1996. The Company's sales of
     bulk bSOD beyond 1997 are uncertain and difficult to predict and no
     assurances can be given with respect thereto.

     Sales of Palosein/(R)/, which was reintroduced to the U.S. market in 1993
     and is sold primarily to veterinary wholesalers in the United States,
     increased from $346,000 in 1994 to $555,000 in 1995 as a result of an
     active direct mail marketing campaign, but declined to $480,000 in 1996 due
     in part to large stocking orders by distributors in late 1995. The decrease
     in other sales was principally the result of the completion of an assay
     development contract in early 1996. Royalties and license fees are not
     expected to be material in 1997.


COSTS AND EXPENSES

     Cost of sales as a percent of product sales declined from 62% in 1994 to
     59% in 1995. In 1995 the cost of the Company's diagnostic and research
     assays declined slightly as a result of increased volumes, and the cost of
     bulk bSOD sales also declined from the 1994 level. In 1996 cost of sales
     increased to 63% of product sales. The increase was primarily caused by a
     decline in the gross margin on bulk bSOD sales. The Company's cost of sales
     includes amortization of technology acquired in 1994 ($239,000 in 1994, and
     $737,000 in 1995 and 1996).

     Research and development costs increased from $1,670,000 in 1994 to
     $4,299,000 in 1995, and $4,908,000 in 1996. The increase in 1995 was
     primarily due to the cost of the research and development activities
     associated with pharmaceutical technologies acquired in the September 1994
     and July 1995 business acquisitions. The increase of $609,000 in 1996 is
     the result of increased expenditures relating to preclinical development
     work and the Phase I clinical trial on the Company's lead therapeutics
     program (glutathione peroxidase mimics) of approximately $1,130,000, and a
     $230,000 increase in expenses of the former Therox operations, offset by a
     cost reduction of approximately $780,000 from the closure of the Company's
     Mountain View, California facility in the fourth quarter of 1995. The
     expenses of the Therox operations are included in the 1995 expenses
     starting in July 1995; the former Therox laboratory facility was closed in
     May 1996.

     Sales, general and administrative expenses increased in 1995 to $3,332,000
     from $1,652,000 in 1994. The increase in 1995 was due primarily to the
     inclusion for the entire year of general and administrative costs of the
     businesses acquired in 1994, further increases in sales and marketing costs
     relating to Palosein/(R)/ and the new products from the 1994 acquisitions,
     and increased legal fees and other expenses relating to the Company's
     ongoing need to raise capital and more complex corporate structure.

                                       13
<PAGE>
 
     In 1996, sales, general and administrative expenses decreased by $491,000,
     to $2,841,000. Most of the decrease was a decrease in the selling, general
     and administrative expenses of the Company's French subsidiary. In the
     third quarter of 1996 all of the Company's manufacturing operations were
     consolidated in the United States and the French subsidiary became a
     research facility. In connection with this restructuring, two
     administrative positions have been eliminated and certain other costs which
     were previously charged to administrative expenses are now being classified
     as research and development costs. The administrative costs of the
     Company's French subsidiary decreased $359,000 in 1996 as compared to 1995.

     Expenses included charges of $3,675,000 and $3,329,000 to operations for
     1994 and 1995, respectively, reflecting the write-off of purchased
     in-process technology, as described in Note 3 to the consolidated financial
     statements.


INTEREST INCOME AND EXPENSE

     Interest income decreased and interest expense increased in 1995 as the
     Company liquidated certificates of deposit and borrowed funds pursuant to
     short-term and long-term interest bearing obligations to finance increased
     research and development efforts.


NET LOSS

     The Company incurred net losses in 1994, 1995 and 1996. The 1994 loss
     includes a $3,675,000 ($.58 per share) charge to operations for the
     write-off of purchased in-process technology related to the acquisitions of
     OXIS S.A. and IBC. Similarly, the 1995 loss includes a $3,329,000 ($.31 per
     share) charge to operations for the write-off of purchased in-process
     technology related to the acquisition of Therox. Excluding these unusual
     charges, the Company would have incurred a net loss of $1,892,000, or $.30
     per share for 1994; a net loss of $5,563,000, or $.51 per share for 1995,
     as compared to a net loss of $5,992,000, or $.47 per share for 1996.

     Increased research and development expenditures and selling, general and
     administrative expenses from the businesses acquired late in the third
     quarter of 1994 and increased research and development expenditures
     relating to the acquisition of Therox early in the third quarter of 1995
     contributed to the increased losses in 1995 as compared to 1994. The
     increased loss for 1996 as compared to 1995 (excluding the unusual charge)
     is attributable primarily to the increased research and development costs
     relating to the Company's glutathione peroxidase mimics program.

     The Company expects to incur a substantial net loss for 1997. If
     substantial additional capital is raised through further sales of
     securities (See Financial Condition, Liquidity and Capital Resources), the
     Company plans to continue to invest in research and development activities
     and incur sales, general and administrative expenses in amounts greater
     than its anticipated near-term product margins. If the Company is unable to
     raise sufficient 

                                       14
<PAGE>
 
     additional capital, it will have to cease, or severely curtail, its
     operations. In this event, while expenses will be reduced, expense levels,
     and the potential write down of various assets, would still be in amounts
     greater than anticipated revenues.

                                       15
<PAGE>
 
ITEM 8.    FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA.

                           CONSOLIDATED BALANCE SHEETS
                           DECEMBER 31, 1996 AND 1995

                                               1996              1995
ASSETS
Current assets:
     Cash and cash equivalents              $    422,000      $    727,000
     Accounts receivable                         861,000           823,000
     Inventories                                 591,000           953,000
     Prepaid and other                           191,000           262,000
                                              ----------        ----------
         
         Total current assets                  2,065,000         2,765,000

Property and equipment, net                    1,327,000         1,092,000

Assets under capital leases, net                 309,000         1,198,000

Technology for developed products and
     custom assays, net                        3,782,000         4,498,000

Other assets                                     514,000           317,000
                                              ----------        ----------

         Total assets                         $7,997,000        $9,870,000
                                              ==========        ==========



                             See accompanying notes.

                                       16
<PAGE>
 
                           CONSOLIDATED BALANCE SHEETS
                           DECEMBER 31, 1996 AND 1995
<TABLE>
<CAPTION>
                                                                                        1996              1995
LIABILITIES AND SHAREHOLDERS' EQUITY
<S>                                                                                  <C>               <C>   
Current liabilities:
     Notes payable                                                                   $  1,221,000      $  1,616,000
     Accounts payable                                                                   1,386,000         1,182,000
     Customer deposits                                                                    132,000           250,000
     Accrued liabilities                                                                  655,000           903,000
     Current portion of capital lease obligations                                          76,000           283,000
                                                                                   --------------    --------------
         Total current liabilities                                                      3,470,000         4,234,000

Capital lease obligations                                                                      --            47,000
8% convertible subordinated debentures                                                         --         1,255,000
Other liabilities                                                                           2,000            30,000

Commitments and contingencies (Notes 1, 3 and 11)

Shareholders' equity:
     Preferred stock - $.01 par value; 15,000,000 shares authorized:
         Series B - 642,583 shares issued and outstanding at December 31, 1996
         and 1995 (liquidation
         preference of $1,500,000)                                                          6,000             6,000
         Series C - 1,647,157 shares issued and outstanding
         at December 31, 1996                                                              17,000                --
         Series D - 1,650 shares issued and outstanding
         at December 31, 1996                                                                  --                --
         Series E - 2,200 shares issued and outstanding
         at December 31, 1996                                                                  --                --
     Common stock - $.50 par value; 40,000,000 shares
       authorized; 13,790,736 shares issued and outstanding                             6,895,000         6,062,000
     Additional paid in capital                                                        30,706,000        25,210,000
     Accumulated deficit                                                              (33,023,000)      (27,031,000)
     Accumulated translation adjustments                                                  (76,000)           57,000
                                                                                   --------------    --------------

       Total shareholders' equity                                                       4,525,000         4,304,000
                                                                                   --------------     -------------

              Total liabilities and shareholders' equity                           $    7,997,000     $   9,870,000
                                                                                   ==============     =============
</TABLE>

                             See accompanying notes.

                                       17
<PAGE>
 
                      CONSOLIDATED STATEMENTS OF OPERATIONS
                  YEARS ENDED DECEMBER 31, 1996, 1995 AND 1994
<TABLE>
<CAPTION>
                                                                              1996              1995            1994
<S>                                                                    <C>                 <C>             <C>    
Revenues:
     Sales                                                              $  4,802,000       $  4,982,000    $  3,325,000
     Royalties and license fees                                               65,000            154,000         145,000
                                                                        ------------       ------------   -------------

       Total revenues                                                      4,867,000          5,136,000       3,470,000


Costs and expenses:
     Cost of sales                                                         3,009,000          2,939,000       2,074,000
     Research and development                                              4,908,000          4,299,000       1,670,000
     Sales, general and administrative                                     2,841,000          3,332,000       1,652,000
     Purchased in-process technology (Note 3)                                     --          3,329,000       3,675,000
                                                                        ------------       ------------   -------------
       Total costs and expenses                                           10,758,000         13,899,000       9,071,000
                                                                        ------------       ------------   -------------

Operating loss                                                            (5,891,000)        (8,763,000)     (5,601,000)

Interest income                                                               37,000             42,000          82,000

Interest expense                                                            (138,000)         (171,000)        (48,000)
                                                                        ------------       ------------     -----------
Net loss                                                                $ (5,992,000)      $ (8,892,000)    $(5,567,000)
                                                                        ============       ============     ===========

Net loss per share                                                      $       (.47)      $     (0.82)     $     (0.88)
                                                                        ============       ============     ===========
 

Weighted average number of shares
     used in computation                                                  12,821,544         10,854,149       6,350,097
                                                                        ============       ============     ===========
 
</TABLE> 
                              See accompanying notes.

                                       18
<PAGE>
 
                      CONSOLIDATED STATEMENTS OF CASH FLOWS
                   YEARS ENDED DECEMBER 31, 1996, 1995 AND 1994
<TABLE> 
<CAPTION>
                                                                            1996               1995             1994
<S>                                                                      <C>                <C>             <C>    
Cash flows from operating ativities:
     Net loss                                                            $(5,992,000)       $(8,892,000)    $(5,567,000)
     Adjustments to reconcile net loss to cash provided
       by (used for) operating activities:
         Depreciation and amortization                                     1,381,000          1,369,000         551,000
         Purchased in-process technology                                          --          3,329,000       3,675,000
         Changes in assets and liabilities:
           Accounts receivable                                               (50,000)           (70,000)        258,000
           Inventories                                                       355,000            (17,000)       (186,000)
           Other current assets                                               (2,000)           209,000         (19,000)
           Accounts payable                                                  220,000           (565,000)        562,000
           Customer deposits                                                (118,000)          (866,000)      1,116,000
           Accrued liabilities                                               (69,000)           251,000          (8,000)
                                                                         -----------        -----------    ------------

              Net cash provided by (used for)
                operating activities                                      (4,275,000)        (5,252,000)        382,000

Cash flows from investing activities:
     Redemption of certificates of deposit                                        --            496,000         884,000
     Purchase of equipment                                                   (58,000)           (99,000)        (40,000)
     Acquisition and stock issuance costs (Note 3)                                --                 --      (1,361,000)
     Cash of businesses acquired (Note 3)                                         --            143,000         273,000
     Additions to patent and deferred financing costs                       (350,000)                --              --
     Other                                                                    (1,000)          (136,000)         19,000
                                                                         -----------        -----------    ------------

              Net cash provided by (used for)
                investing activities                                        (409,000)           404,000        (225,000)

Cash flows from financing activities:
     Short-term borrowing                                                  1,061,000          1,366,000         296,000
     Proceeds from issuance of long-term debt                                     --          1,255,000              --
     Costs in connection with issuance of long-term debt                          --           (152,000)             --
     Proceeds from issuance of stock, net of related cost                  4,305,000          3,077,000              --
     Repayment of short-term notes                                          (690,000)          (340,000)             --
     Repayment of capital lease obligations and
       other liabilities                                                    (294,000)          (573,000)       (275,000)
                                                                         -----------        -----------    ------------

              Net cash provided by financing activities                    4,382,000          4,633,000          21,000

Effect of exchange rate changes on cash                                       (3,000)             6,000               --
                                                                         -----------        -----------    ------------
 
Net increase (decrease) in cash and cash equivalents                        (305,000)          (209,000)        178,000

Cash and cash equivalents - beginning of year                                727,000            936,000         758,000
                                                                         -----------        -----------    ------------

Cash and cash equivalents - end of year                                  $   422,000        $   727,000    $    936,000
                                                                         ===========        ===========    ============
</TABLE>

                             See accompanying notes.

                                       19
<PAGE>
 
                CONSOLIDATED STATEMENTS OF CASH FLOWS (CONTINUED)
                  YEARS ENDED DECEMBER 31, 1996, 1995 AND 1994
<TABLE>
<CAPTION>
                                                                 1996         1995       1994
<S>                                                           <C>           <C>           <C>    

Supplemental schedule of noncash operating and 
  financing activities:
   Inventory purchase with deferred payment terms                     --     $250,000      --
   Common stock issued as incentive to purchase notes                 --     $156,000      --
   Issuance of Series C Preferred Stock in exchange
       for cancellation of notes                              $  844,000           --      --
   Conversion of 8% Convertible Subordinated Debentures
       into Common Stock                                      $1,312,000           --      --
   Conversion of Series C and D Preferred Stock into
       Common Stock                                           $  515,000           --      --

</TABLE>




                             See accompanying notes.

                                       20
<PAGE>
 
                 CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY
                  YEARS ENDED DECEMBER 31, 1996, 1995 AND 1994

<TABLE>
<CAPTION>
                                    Preferred Stock             Common Stock            Additional
                                    ---------------             ------------              paid-in
                                 Shares         Amount      Shares         Amount         capital
<S>                            <C>          <C>           <C>          <C>             <C>
Balances,
  January 1, 1994                                           4,982,670  $ 2,491,000     $12,863,000
Series A preferred and
  common shares issued in
  connection with 1994
  business combinations
  (Note 3)                        40,000       $   --       4,340,092     2,170,000      7,367,000
Accumulated
  translation adjustments
Net loss
                              ----------        -------    ----------    ----------     ----------
Balances,
  December 31, 1994               40,000           --       9,322,762     4,661,000     20,230,000
Shares issued in
  connection with short-
  term notes                                                   93,300        47,000        109,000
Sale of common shares                                       1,227,625       614,000      1,089,000
Conversion of Series A
  preferred shares to
  common                         (40,000)          --          40,000        20,000       (20,000)
Shares issued in
  connection  with 1995
  business combination
  (Note 3)                                                  1,440,736       720,000     2,633,000
Series B preferred shares
  issued (Note 3)                642,583          6,000                                 1,169,000
Accumulated translation
  adjustments
Net loss
                              ----------        -------    ----------    ----------     ----------
Balances,
  December 31, 1995              642,583          6,000    12,124,423     6,062,000    25,210,000
Sale of Series C preferred
  shares for cash              1,125,590         11,000                                 1,225,000
Series C preferred shares
  issued in exchange for
  cancellation of notes          648,490          7,000                                   837,000
Sale of Series D
  preferred shares                 2,000           --                                   1,939,000

<CAPTION>

                                                  Accumulated         Total
                                Accumulated       translation      shareholders'
                                  deficit         adjustments         equity
                                  -------         -----------         ------
<S>                             <C>               <C>              <C>
Balances,
  January 1, 1994               $(12,572,000)                      $ 2,782,000
Series A preferred and
  common shares issued in
  connection with 1994
  business combinations
  (Note 3)                                                           9,537,000
Accumulated translation
  adjustments                                        $(53,000)         (53,000)
Net loss                          (5,567,000)                       (5,567,000)
                                 -----------          -------       ----------
Balances,
  December 31, 1994              (18,139,000)         (53,000)       6,699,000
Shares issued in
  connection with short-
  term notes                                                           156,000
Sale of common shares                                                1,703,000
Conversion of Series A
  preferred shares to
  common                                                                  --
Shares issued in
  connection  with 1995
  business combination
  (Note 3)                                                           3,353,000
Series B preferred shares
  issued (Note 3)                                                    1,175,000
Accumulated translation
  adjustments                                         110,000          110,000
Net loss                          (8,892,000)                       (8,892,000)
                                 -----------          -------       ----------
Balances,
  December 31, 1995              (27,031,000)          57,000        4,304,000
Sale of Series C preferred
  shares for cash                                                    1,236,000
Series C preferred shares
  issued in exchange for
  cancellation of notes                                                844,000
Sale of Series D
  preferred shares                                                   1,939,000
</TABLE>

                                       21
<PAGE> 
 
           CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY (CONTINUED)
                  YEARS ENDED DECEMBER 31, 1996, 1995 AND 1994

<TABLE> 
<CAPTION> 
                                  Preferred Stock             Common Stock                
                                  ---------------             ------------                
                                  Shares    Amount        Shares        Amount          
<S>                           <C>           <C>        <C>          <C> 
Common shares issued
  upon conversion of
  debentures                                            1,050,217      525,000       
Conversion of Series C
  preferred shares to
  common stock                  (126,923)    (1,000)      136,924       69,000       
Conversion of Series D
  preferred shares to
  common stock                      (350)        --       360,839      180,000       
Sale of Series E preferred
  and common shares for
  cash                             2,200         --        55,000       27,000       
Other issuances of common
  shares                                                   63,333       32,000       
Accumulated translation
  adjustments                                                                        
Net Loss                                                                             
                               ---------    -------    ----------   ----------
Balances,
  December 31, 1996            2,293,590    $23,000    13,790,736   $6,895,000       
                               =========    =======    ==========   ==========       
<CAPTION>
                             
                                 Additional                  Accumulated        Total   
                                  paid-in      Accumulated   translation     shareholders'
                                  capital        deficit     adjustments        equity  
<S>                             <C>           <C>            <C>             <C>    
Common shares issued                                                                       
  upon conversion of                                                                     
  debentures                      787,000                                     1,312,000  
Conversion of Series C                                                                   
  preferred shares to                                                                    
  common stock                    (68,000)                                           --  
Conversion of Series D                                                                   
  preferred shares to                                                                    
  common stock                   (180,000)                                           --  
Sale of Series E preferred                                                               
  and common shares for                                                                  
  cash                            923,000                                       950,000  
Other issuances of common                                                                
  shares                           33,000                                        65,000  
Accumulated translation                                                                  
  adjustments                                                   (133,000)      (133,000) 
Net Loss                                        (5,992,000)                  (5,992,000) 
                              -----------     ------------     ---------     ----------
Balances,                                                                                
  December 31, 1996           $30,706,000     $(33,023,000)    $ (76,000)    $4,525,000  
                              ===========     ============     =========     ==========  
</TABLE>


                            See accompanying notes.

                                       22
<PAGE>
 
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                  YEARS ENDED DECEMBER 31, 1996, 1995 AND 1994


1.   DESCRIPTION OF BUSINESS AND BASIS OF PRESENTATION

     OXIS International, Inc. (the "Company") develops, manufactures and markets
     selected therapeutic and diagnostic products. The Company's research and
     development efforts are concentrated principally in the development of
     products to diagnose, treat and prevent diseases associated with free
     radicals and reactive oxygen species. The Company is headquartered in
     Portland, Oregon and operates a research and development facility near
     Paris, France.

     The Company has historically licensed and sold pharmaceutical forms of
     superoxide dismutase (SOD) for human and veterinary use. In 1994, with the
     acquisitions of businesses as described in Note 3, the Company began
     selling therapeutic drug monitoring assays and research assays to measure
     markers of oxidative stress.

     Therapeutic drug monitoring assays are manufactured by the Company in the
     United States and are sold to hospital clinical laboratories and reference
     laboratories by an in-house sales force and a network of distributors both
     within and outside the United States. Assays to measure markers of
     oxidative stress are manufactured by the Company in the United States (in
     France prior to July, 1996) and are sold directly to researchers and to
     distributors for resale to researchers, primarily in Europe, the United
     States and Japan.

     These financial statements have been prepared on a going concern basis
     which contemplates the realization of assets and the satisfaction of
     liabilities in the normal course of business. The Company has incurred
     losses in each of the last three years, and at December 31, 1996, the
     Company's current liabilities exceeded its current assets by $1,405,000.
     These factors, among others, may indicate that the Company may be unable to
     continue as a going concern for a reasonable period of time. These
     financial statements do not include any adjustments relating to the
     recoverability and classification of recorded asset amounts or the amounts
     and classification of liabilities that may be necessary should the Company
     be unable to continue as a going concern. The Company's continuation as a
     going concern is contingent upon its ability to obtain additional
     financing, and to generate revenue and cash flow to meet its obligations on
     a timely basis.

     During 1996, the Company raised approximately $5,300,000 cash through the
     sale of its Series C, Series D and Series E Preferred Stock and common
     stock, and convertible term notes. The Company expects that additional
     capital will be required during 1997 to continue operating in accordance
     with its current plans. The Company has engaged an agent to assist on a
     best-efforts basis to complete a private placement of its common stock. In
     addition, the Company has engaged a French investment banker to act as its
     underwriter for a planned public offering of its common stock on the newly
     opened French stock market, Le Nouveau

                                       23
<PAGE>
 
     Marche, subject to obtaining appropriate authorization from the French
     stock market regulatory authorities. If the Company is unable to raise
     additional capital it intends to curtail its operations through the
     reduction of personnel and facility costs and by reducing its research and
     development efforts. If the Company were to be unable to sufficiently
     curtail its costs in such a situation, it might be forced to seek
     protection of the courts through reorganization, bankruptcy or insolvency
     proceedings.


2.   SIGNIFICANT ACCOUNTING POLICIES

     PRINCIPLES OF CONSOLIDATION - The accompanying balance sheets include the
     accounts of the Company as well as its subsidiaries. The results of
     operations of the Company's French subsidiary since its purchase by the
     Company on September 7, 1994, are included in the accompanying statements
     of operations and cash flows. The functional currency of the Company's
     French subsidiary is the French franc. The French subsidiary's assets and
     liabilities are translated at the exchange rate at the end of the year, and
     its statement of operations is translated at the average exchange rates
     during the period for which its revenues and expenses are included in the
     consolidated statement of operations. Gains or losses resulting from
     foreign currency translation are accumulated as a separate component of
     shareholders' equity. All significant intercompany balances and
     transactions are eliminated in consolidation.

     CASH EQUIVALENTS consist of money market accounts with commercial banks.

     INVENTORIES are stated at the lower of cost or market. Cost has been
     determined by using the first-in, first-out and specific identification
     methods. Inventories at December 31, 1996 and 1995, consisted of the
     following:

                                    1996             1995

        Raw materials             $148,000         $173,000
        Work in process            200,000          354,000
        Finished goods             243,000          426,000
                                  --------         --------

        Total                     $591,000         $953,000
                                  ========         ========


     PROPERTY AND EQUIPMENT is stated at cost, or, in the case of property and
     equipment acquired in transactions accounted for by the purchase method, at
     the estimated fair market value at the date of the acquisition (which is
     then considered to be the Company's cost). Depreciation of equipment is
     computed using the straight-line method over estimated useful lives of
     three to ten years. Leasehold improvements are amortized over the shorter
     of five years or the remaining lease term. Assets acquired under capital
     leases are being amortized over estimated useful lives of four to ten
     years.

                                       24
<PAGE>
 
     Property and equipment at December 31, 1996 and 1995, consisted of the
     following:

                                                      1996             1995

        Furniture and office equipment            $   369,000       $  346,000
        Laboratory and manufacturing
          equipment                                 2,495,000          707,000
        Automobile                                     15,000           15,000
        Leasehold improvements                        766,000          806,000
                                                  -----------       ----------

            Property and equipment, at cost         3,645,000        1,874,000

        Accumulated depreciation and
          amortization                             (2,318,000)        (782,000)
                                                  -----------      -----------

            Property and equipment, net           $ 1,327,000       $1,092,000
                                                  ===========       ==========

     During 1996 certain equipment under capital lease was purchased, and the
     cost and accumulated amortization of that equipment was reclassified to
     property and equipment.

     TECHNOLOGY - Technology for developed products and custom assays, which was
     acquired in the 1994 business combinations described in Note 3, is being
     amortized over estimated useful lives of seven to ten years. Accumulated
     amortization of technology for developed products and custom assays was
     $1,682,000 as of December 31, 1996 and $973,000 as of December 31, 1995.
     The Company periodically reviews net cash flows from sales of products and
     projections of net cash flows from sales of products on an undiscounted
     basis to assess recovery of intangible assets.

     STOCK OPTIONS - The Company applies the intrinsic value based method
     described in Accounting Principles Board Opinion No. 25, "Accounting for
     Stock Issued to Employees", in accounting for its stock incentive plan.

     REVENUE RECOGNITION - The Company recognizes product sales upon shipment of
     the product to the customer.

     INCOME TAXES - Deferred income taxes, reflecting the net tax effects of
     temporary differences between the carrying amount of assets and liabilities
     recognized for financial reporting purposes and the amounts recognized for
     income tax purposes, are based on tax laws currently enacted. A valuation
     allowance is established when necessary to reduce deferred tax assets to
     the amount expected to be realized.

     NET LOSS PER SHARE - Net loss per share is computed based upon the average
     number of common shares outstanding and, if dilutive, the incremental
     shares issuable upon the assumed exercise of stock options or warrants and
     the assumed conversion of convertible debentures and preferred stock.

                                       25
<PAGE>
 
     USE OF ESTIMATES - The preparation of financial statements in conformity
     with generally accepted accounting principles requires management to make
     estimates and assumptions that affect the reported amounts of assets and
     liabilities and disclosure of contingent assets and liabilities at the date
     of the financial statements and the reported amounts of sales and expenses
     during the reporting period. Actual results could differ from those
     estimates.

     FAIR VALUE OF FINANCIAL INSTRUMENTS - The carrying amount reported in the
     balance sheet for cash and cash equivalents, accounts receivable, notes
     payable, customer deposits and accrued liabilities approximates fair value
     due to the short-term nature of the accounts. The carrying amount reported
     in the balance sheet for secured convertible term notes and 8% convertible
     subordinated debentures approximates fair value because the terms of the
     notes and debentures were determined and the notes and debentures were sold
     shortly before the dates of the balance sheets in which they appear.


3.   BUSINESS COMBINATIONS

     On September 7, 1994, the Company acquired Bioxytech S.A., a French
     company, and International BioClinical, Inc. ("IBC"), an Oregon
     corporation. The name of Bioxytech S.A. was subsequently changed to OXIS
     International S.A. ("OXIS S.A."). OXIS S.A. was acquired through an
     exchange of shares that resulted in the Company owning in excess of 99% of
     the outstanding stock of OXIS S.A., which thus became a subsidiary of the
     Company. IBC was acquired through a merger with and into the Company, which
     (1) terminated the separate existence of IBC by merging it into the
     Company, and (2) resulted in the conversion of the outstanding stock of IBC
     into stock of the Company. Two of the Company's directors were also
     directors and major shareholders of IBC.

     In exchange for the Bioxytech S.A. shares, the Company issued a total of
     2,341,599 shares of the Company's common stock and 40,000 shares of the
     Company's non-voting preferred stock (which have subsequently been
     converted into 40,000 shares of common stock). In addition, the Bioxytech
     S.A. shareholders may receive up to 107,670 shares of the Company's capital
     stock if they meet certain participation levels in a contemplated private
     placement of equity securities of the Company.

     The merger of IBC with and into the Company resulted in the conversion of
     IBC's common stock into 1,998,493 shares of the Company's common stock.

     The acquisitions of OXIS S.A. and IBC have been accounted for as purchases
     and, accordingly, the acquired assets and liabilities were recorded at
     their estimated fair market values as of the date of acquisition. The
     aggregate purchase price of $9,811,000 (4,380,092 shares issued times the
     average per share closing price of the Company's common stock for the five
     days ended September 8, 1994, discounted 30% for certain trading
     restrictions and less costs of $274,000 directly attributable to issuance
     of stock in connection with the acquisitions) plus direct costs for the
     acquisitions of $881,000 have been allocated to the 

                                       26
<PAGE>
 
     assets and liabilities acquired. The Company also issued options to
     purchase 214,700 shares of the Company's common stock in connection with
     the acquisitions. No value was assigned to these options because the
     exercise price of the options was in excess of the market value of the
     common stock.

     The total cost of the acquisitions of Bioxytech and IBC has been allocated
     to the assets acquired and liabilities assumed as follows:
<TABLE>
<CAPTION>
                                                        OXIS S.A.              IBC            Total
                                                        ---------              ---            -----
<S>                                                    <C>               <C>             <C>  
         Cash                                          $   150,000       $   123,000     $   273,000
         Other assets                                      369,000           611,000         980,000
         Property, equipment and capitalized
           leases                                        2,434,000           294,000       2,728,000
         Technology for developed products and
           custom assay development capabilities         1,503,000         3,995,000       5,498,000
         Technology for in-process products              3,368,000           307,000       3,675,000

         Less liabilities assumed                       (2,011,000)         (451,000)     (2,462,000)
                                                       -----------       -----------     -----------

         Total acquisition cost                        $ 5,813,000       $ 4,879,000     $10,692,000
                                                       ===========       ===========     ===========
</TABLE>


     The Company's consolidated results of operations include the operating
     results of the acquired companies since the acquisitions.

     Approximately $3,675,000 ($.58 per share) of the total purchase price
     represented technology relating to research and development projects that
     were in process by the acquired companies that had no alternative future
     use other than the completion of these projects. In accordance with
     generally accepted accounting principles, these costs have been charged to
     operations immediately upon completion of the acquisitions.

     The following table summarizes the unaudited pro forma combined results of
     operations for the year ended December 31, 1994 as if the acquisitions had
     occurred at the beginning of the year:

                                                                 1994

              Total revenues                                 $ 5,809,000

              Net loss                                       $(4,742,000)

              Net loss per share (based on 9,322,762
                shares outstanding)                          $      (.51)

                                       27
<PAGE>
 
     The above table includes, on an unaudited pro forma basis, the Company's
     financial information for the year ended December 31, 1994, combined with
     the financial information of OXIS S.A. and IBC for the same twelve-month
     period. The above table excludes the one-time $3,675,000 charge for
     purchased in-process technology arising from the acquisitions.

     The unaudited pro forma combined results of operations are presented for
     illustrative purposes only and are not necessarily indicative of the
     operating results that would have occurred had the acquisitions been
     consummated at the beginning of the period presented, nor are they
     necessarily indicative of future operating results.

     On July 19, 1995, the Company consummated the acquisition of Therox
     Pharmaceuticals, Inc. ("Therox") pursuant to a transaction wherein Therox
     was merged with and into a wholly-owned subsidiary of the Company. Therox
     was a Philadelphia-based start-up company focused on the development of
     therapeutics to treat diseases associated with damage from free radicals.
     The Company issued 1,440,736 shares of its common stock to Therox
     stockholders in exchange for all of the Therox capital stock. In addition,
     the acquisition agreement provides for payment of up to $2,000,000 by the
     Company to the Therox stockholders based on the successful
     commercialization of the Therox technologies.

     The acquisition of Therox has been recorded as a purchase and, accordingly,
     the acquired assets and liabilities were recorded at their estimated fair
     values as of the date of acquisition. The aggregate purchase price of
     $3,353,000 (1,440,736 shares issued times the average per share closing
     price of the Company's common stock for the five days ended July 20, 1995,
     discounted 30% for certain trading restrictions) has been allocated to the
     assets and liabilities acquired.

     The cost of the acquisition of Therox has been allocated to the assets
     acquired and liabilities assumed as follows:

                  Cash                                       $  143,000
                  Equipment                                      16,000
                  Technology for in-process products          3,329,000
                  Other assets                                   23,000
                  Less liabilities assumed                     (158,000)
                                                             ----------
                                    Acquisition cost         $3,353,000
                                                             ==========

     The Company's consolidated results of operations include the operating
     results of the acquired company since the acquisition.

     Approximately $3,329,000 of the purchase price represented technology
     related to research and development projects that are in process and that
     has no alternative future use other than the completion of these projects.
     Accordingly, these costs have been charged to operations immediately upon
     completion of the acquisition.

                                       28
<PAGE>
 
     The following table presents the unaudited pro forma combined results of
     operations for the years ended December 31, 1995 and 1994 as if the
     acquisition had occurred at the beginning of the periods presented:

                                                    1995              1994
                                                    ----              ----

          Total revenues                          $ 5,136,000     $ 3,470,000

          Net loss                                $(5,990,000)    $(6,088,000)

          Net loss per share (based
          on 12,124,423 shares outstanding)       $      (.49)    $      (.50)

     The above table includes, on an unaudited pro forma basis, the Company's
     financial information for the years ended December 31, 1995 and 1994,
     combined with the financial information of Therox for the same periods. The
     above table excludes the one-time $3,329,000 charge for purchased
     in-process technology arising from the 1995 acquisition, but includes
     non-recurring costs of $3,675,000 for purchased in-process technology from
     the Company's September 1994 business acquisitions.

     The unaudited pro forma combined results of operations are presented for
     illustrative purposes only and are not necessarily indicative of the
     operating results that would have occurred had the acquisition been
     consummated at the beginning of the periods presented, nor are they
     necessarily indicative of future operating results.

     Simultaneously with the Therox acquisition, a Series B Preferred Stock
     Purchase Agreement was entered into between the Company and two venture
     capital firms (S.R. One, Limited and Brantley Venture Partners II, L.P.)
     which were major stockholders of Therox. Pursuant to this agreement, the
     Company sold 642,583 shares of its Series B Preferred Stock for an
     aggregate price of $1,500,000.

     Costs of approximately $325,000 directly attributable to the issuance of
     the Series B Preferred Stock and the common stock issued in the Therox
     acquisition have been recorded as a reduction in the proceeds from the
     issuance of the shares.

                                       29
<PAGE>
 
4.   NOTES PAYABLE

     Notes payable at December 31, 1996 and 1995 consisted of the following:
<TABLE>
<CAPTION>
                                                                                 1996               1995
<S>                                                                           <C>               <C>    

         Secured convertible term notes                                       $1,000,000        $       --

         8%  notes  payable  to  certain  shareholders  who are  former
         Bioxytech  S.A.  shareholders,  due February 5, 1996,  secured
         by assets  relating  to  certain of the  Company's  diagnostic
         products                                                                     --           766,000

         Note payable to Sanofi S.A., due May 4, 1996, interest at prime 
         plus 2% (10-1/2% as of December 31, 1995), secured by  all of 
         the Company's assets                                                         --           600,000

         Liability, without interest, under inventory purchase agreement, 
         due May 1997 or earlier if 75% of the related inventory
         is sold                                                                 200,000           250,000

         Other                                                                    21,000                --
                                                                              ----------        ----------
                                                                              $1,221,000        $1,616,000
                                                                              ==========        ==========
</TABLE>

     In October 1996, the Company sold $1,000,000 of secured convertible term
     notes with warrants to two of the Company's current shareholders. The notes
     bear interest at 10% per annum, are due in June 1997, and are initially
     convertible into common stock at a price of $1.4125 per share. The warrants
     issued entitle the holders to purchase up to 300,000 shares of common
     stock, initially at an exercise price of $1.58 per share. The conversion
     rate of the convertible term notes and the exercise price of the warrants
     are subject to change under certain circumstances. The due date of the
     notes can be extended at the option of the Company for 120 days upon
     issuance of additional warrants to the holders. The convertible term notes
     are secured by assets relating to the Company's clinical diagnostic
     products.

     As described in Note 7, in May 1996, the 8% notes payable were canceled in
     exchange for issuance of Series C
     Preferred Stock.


5.   CAPITALIZED LEASES

     The Company's French subsidiary leases certain equipment, furniture and
     fixtures under capital leases. As of December 31, 1996, remaining minimum
     lease payments on these capital leases were approximately $48,000, all due
     in 1997.

                                       30
<PAGE>
 
     Leased assets, which consist principally of laboratory and office
     equipment, are reported in the December 31, 1996, balance sheet at $622,000
     less accumulated amortization of $313,000.


6.   8% CONVERTIBLE SUBORDINATED DEBENTURES

     In November and December 1995, the Company completed a private placement
     pursuant to which $1,255,000 of its 8% Convertible Subordinated Debentures
     were issued. The debentures were unsecured and were subordinated to other
     obligations of the Company up to an aggregate of $3,000,000.

     The debentures were convertible into shares of the Company's common stock
     at the option of the holders. Any time after six months following closing
     of the private placement, the Company had the right to require conversion
     of the debentures. In June 1996, $1,255,000 principal plus accrued interest
     of $57,000 on the Company's 8% Convertible Subordinated Debentures were
     converted into 1,050,217 shares of common stock.


7.   SHAREHOLDERS' EQUITY

     PREFERRED STOCK - Terms of the preferred stock are to be fixed by the Board
     of Directors at such time as the preferred stock is issued. The 40,000
     shares of Series A Preferred Stock issued during 1994 were nonvoting and
     were converted to common stock on a one share for one share basis during
     1995. The 642,583 shares of Series B Preferred Stock are convertible into
     common stock on a one-for-one basis and have the same voting rights as the
     common stock. The Series B Preferred Stock has certain preferential rights
     with respect to liquidation and dividends.

     During the first six months of 1996, the Company issued 1,125,590 shares of
     its Series C Preferred Stock for net cash proceeds of $1,236,000. In
     addition, in May 1996, the Company issued 648,490 shares of its Series C
     Preferred stock in exchange for the cancellation of $766,000 principal plus
     accrued interest of $78,000 on 8% notes payable to former shareholders of
     the Company's French subsidiary. The shares of Series C Preferred Stock are
     convertible into shares of the Company's common stock at the option of the
     holders at any time. The conversion ratio is based on the average closing
     bid price of the common stock for the fifteen consecutive trading days
     ending on the date immediately preceding the date notice of conversion is
     given, but cannot be less than one nor more than 1.4444 common shares for
     each Series C Preferred share. The conversion ratio may be adjusted under
     certain circumstances, and the Company has the right to automatically
     convert the Series C Preferred Stock into common stock under certain
     circumstances. Each share of Series C Preferred Stock is entitled to the
     number of votes equal to 1.30 divided by the average closing bid price of
     the Company's common stock during the fifteen consecutive trading days
     immediately prior to the date such shares of Series C Preferred Stock were
     purchased.

                                       31
<PAGE>
 
     In May 1996, the Company issued 2,000 shares of its Series D Preferred
     Stock and warrants to purchase 810,126 shares of common stock for net cash
     proceeds of $1,939,000. The Series D Preferred Stock entitles the holder
     thereof to convert its shares into a number of shares of common stock
     determined by dividing the stated value of the Series D Preferred Stock
     (i.e., $1,000 per share), plus a premium in the amount of 8% per annum of
     the stated value from the date of issuance, by a conversion price equal to
     the lesser of (i) $2.30 and (ii) 75% of the average of the closing bid
     prices for shares of common stock for the five trading days immediately
     prior to conversion, but limited to a maximum of 2,424,884 shares of common
     stock. The holders of Series D Preferred Stock have no voting power, except
     as specifically provided by Delaware General Corporation Law.

     In December 1996, the Company issued 2,200 shares of its Series E Preferred
     Stock and 55,000 shares of common stock for net cash proceeds of $950,000.

     The Series E Preferred Stock entitles the holder thereof, after the earlier
     of (i) April 9, 1997 or (ii) 30 days following the closing of a public
     offering by the Company, to receive in exchange for its shares of Series E
     Preferred Stock, a number of shares of common stock determined by dividing
     the stated value of the Series E Preferred Stock (i.e., $500 per share)
     ("Series E Stated Value"), by a conversion price equal to the lesser of (i)
     $2.00 and (ii) 75% of the average of the closing bid prices for shares of
     common stock for the five consecutive trading days ending one trading day
     prior to conversion, subject to adjustment upon the occurrence of certain
     dilutive events. However, the maximum number of shares of common stock
     issuable upon conversion of the Series E Preferred Stock plus the number of
     shares of common stock issued in connection with the sale of the Series E
     Preferred Stock is 2,733,799 shares (subject to adjustment upon the
     occurrence of certain dilutive events).

     Pursuant to the terms of the Series E Preferred Stock, each holder thereof
     can only acquire shares of common stock upon conversion of the Series E
     Preferred Stock to the extent that the number of shares of common stock
     thereby issuable, together with a number of shares of common stock then
     held by such holder and its affiliates (not including shares of common
     stock underlying converted shares of Series E Preferred Stock) would not
     exceed 4.9% of the then outstanding common stock.

     The Series E Preferred Stock has no voting power except as provided under
     the Delaware General Corporation Law.

     STOCK WARRANTS - In prior years, the Company issued warrants to purchase
     shares of common stock to certain officers and key employees (none of whom
     any longer hold a position with the Company) and to former directors. These
     warrants are exercisable at $2.875 per share and expire through 1999. At
     December 31, 1996 and 1995, warrants to purchase 1,012,500 shares were
     outstanding and exercisable. No warrants were exercised during 1994, 1995
     or 1996.

     In connection with the issuance of common stock, 8% Convertible
     Subordinated Debentures, and Series B, C and E Preferred Stock, the Company
     has issued to its placement agents 

                                       32
<PAGE>
 
     warrants to purchase 614,573 shares of common stock at prices ranging from
     $1.375 to $3.25 per share. The warrants all remained outstanding and were
     exercisable at December 31, 1996.

     A warrant to purchase 810,126 common shares at $3.09 per share was issued
     to the purchaser of the Company's Series D Preferred Stock. The warrant was
     immediately exercisable and remained outstanding as of December 31, 1996.

     Warrants to purchase 300,000 common shares at $1.58 per share were issued
     to the purchasers of the secured convertible term notes in October 1996.
     The warrants were immediately exercisable and remained outstanding as of
     December 31, 1996.

     STOCK OPTIONS - The Company has a stock incentive plan under which
     2,200,000 shares of the Company's common stock are reserved for issuance.
     The plan permits granting stock options to acquire shares of the Company's
     common stock, awarding stock bonuses of the Company's common stock, and
     granting stock appreciation rights. Options granted pursuant to the Plan
     have a maximum term of ten years; vesting is determined by the Company's
     Compensation Committee. Options granted through 1996 have had vesting
     requirements of up to three years. Options granted and outstanding under
     the plan are summarized as follows:

<TABLE>
<CAPTION>
                                           1996                     1995                     1994
                                           ----                     ----                     ----
                                              Weighted                 Weighted                 Weighted
                                               average                  average                  average
                                              exercise                 exercise                 exercise
                                    Shares     price          Shares    price          Shares    price
<S>                              <C>           <C>            <C>       <C>            <C>       <C>
         Outstanding at
           beginning of year        382,900    $2.93           90,000    $3.44              --       --

         Granted                  1,090,000    $1.57          317,900    $2.73          90,000    $3.44

         Exercised                   (3,333)   $1.69               --    --                 --       --

         Forfeitures                (49,067)   $2.17          (25,000)   $2.25              --       --
                                  ---------    -----          -------    -----          ------    -----
         Outstanding at end
           of year                1,420,500    $1.92          382,900    $2.93          90,000    $3.44
                                  =========                   =======                   ======

         Exercisable at end
           of year                  619,331    $2.29          219,294    $3.18          75,000    $3.50
                                    =======                   =======                   ======
</TABLE>

     The number of shares under option, weighted average exercise price and
     weighted average remaining contractual life of all options outstanding as
     of December 31, 1996, by range of exercise price was as follows:

                                       33
<PAGE>
 
                                               Weighted         Weighted
               Range of                         average          average
               exercise                        exercise         remaining
                 price          Shares           price            life

           $1.31 - $1.69       1,050,000        $1.55          9.5 years
           $2.25 - $2.28         125,500        $2.26          7.7 years
           $3.00 - $3.50         245,000        $3.31          8.1 years

     The number of shares under option and weighted average exercise price of
     options exercisable as of December 31, 1996, by range of exercise price was
     as follows:

                                                          Weighted
                           Range of                        average
                           exercise                       exercise
                             price           Shares        price

                        $1.31 - $1.69        293,999       $1.48
                        $2.25 - $2.28         93,666       $2.26
                        $3.00 - $3.50        231,666       $3.33

     The Company applies Accounting Principles Board Opinion No. 25, "Accounting
     for Stock Issued to Employees", in accounting for its stock incentive plan.
     Accordingly, since the exercise price of all options issued under the plan
     has been less than or equal to the fair market value of the stock at the
     date of issue of the options, no compensation cost has been recognized for
     options granted under the plan. Had compensation cost for options granted
     under the plan been determined based on the fair value at the grant dates
     in a manner consistent with the method determined under Statement of
     Financial Accounting Standards No. 123, "Accounting for Stock-Based
     Compensation", the net loss and net loss per share for 1996 and 1995 would
     have been increased to the pro forma amounts indicated below:

                                          1996              1995
           Net loss:
                As reported          $(5,992,000)       $(8,892,000)
                Pro forma            $(6,389,000)       $(9,210,000)


           Net loss per share:
                As reported          $      (.47)       $      (.82)
                Pro forma            $      (.50)       $      (.85)

     For the purpose of computing the pro forma expense, the fair value of each
     option is estimated on the grant date using the Black-Scholes option
     pricing model with the following assumptions used for grants in both 1996
     and 1995: a dividend yield of zero percent; 

                                       34
<PAGE>
 
     expected volatility of 75%; risk-free interest rate of 6%; and expected
     lives of three years. The weighted average fair value as of the option date
     was computed to be $.83 per share for options issued during 1996 and $1.53
     per share for options issued during 1995.


8.   INCOME TAXES

     INCOME TAX PROVISION - Income tax provisions were not necessary in 1996,
     1995 and 1994 due to net losses.

     DEFERRED TAXES - Deferred taxes reflect the net tax effects of (a)
     temporary differences between the carrying amounts of assets and
     liabilities for financial reporting purposes and the amounts used for
     income tax purposes, and (b) operating losses and tax credit carryforwards.

     The tax effects of significant items comprising the Company's deferred
     taxes as of December 31 were as follows:
<TABLE>
<CAPTION>

     United States taxes:                                                         1996            1995
<S>                                                                            <C>               <C>   
              
               Deferred tax assets:
                  Federal net operating loss carryforward
                    and capitalized research and development
                    expenses                                                   $5,194,000        $4,829,000
                  Federal R&D tax credit carryforward                             522,000           495,000
                  State net operating loss carryforward and capitalized
                    research and development expenses                             211,000           125,000
              Deferred tax liabilities - book basis in excess
                of noncurrent assets acquired in the
                acquisition of IBC                                             (1,102,000)       (1,338,000)
                                                                               -----------       ----------

              Net deferred tax assets                                           4,825,000         4,111,000

              Valuation allowance                                              (4,825,000)       (4,111,000)
                                                                              -----------        ----------

              Net deferred taxes                                              $        --        $       --
                                                                              ===========        ==========

     French taxes:                                                                 1996                1995
              Deferred tax assets:
                  Net operating loss carryforward                              $5,426,000        $5,721,000
                  Impact of temporary differences                                (211,000)         (225,000)
                                                                             ------------       -----------

              Total                                                             5,215,000         5,496,000

              Valuation allowance                                              (5,215,000)       (5,496,000)
                                                                             ------------        ----------

              Net deferred taxes                                             $         --       $        --
                                                                             ============       ===========
</TABLE>

     Temporary differences for French taxes result primarily from leases treated
     as operating leases for French tax reporting and as capital leases in the
     consolidated financial statements.

                                       35
<PAGE>
 
     The tax benefits ($5,136,000) of the net operating losses of $15,410,000
     which existed at the date of acquisition (September 7, 1994) of the French
     subsidiary will be recorded as a reduction of the net unamortized balance
     of property, equipment, capitalized lease assets and intangible assets of
     $2,421,000 when and if realized, and the remaining benefit will be recorded
     as a reduction of income tax expense.

     Statement of Financial Accounting Standards No. 109 requires that the tax
     benefit of net operating losses, temporary differences and credit
     carryforwards be recorded as an asset to the extent that management
     assesses that realization is "more likely than not." Realization of the
     future tax benefits is dependent on the Company's ability to generate
     sufficient taxable income within the carryforward period. Because of the
     Company's recent history of operating losses, management has provided a
     valuation allowance for its net deferred tax assets.


     TAX CARRYFORWARDS - At December 31, 1996, the Company had net operating
     loss carryforwards of approximately $3,995,000 to reduce United States
     federal taxable income in future years, and research and development tax
     credit carryforwards of $522,000 to reduce United States federal taxes in
     future years. In addition, the Company's French subsidiary had operating
     loss carryforwards of $14,801,000 (76,812,000 French francs) to reduce
     French taxable income in future years. These carryforwards expire as
     follows:

                                 United States        R&D tax         French
                                 net operating       credit      operating loss
       Year of expiration    loss carryforward     carryforward   carryforward

            1997                    $2,670,000                     $ 1,200,000
            1998                       208,000                       1,240,000
            1999                       111,000                         220,000
            2000                            --                           6,000
            2001                        23,000      $123,000                --
            2002-2011                  983,000       399,000                --
            No expiration                   --            --        12,135,000
                                    ----------      --------       -----------

                                    $3,995,000      $522,000       $14,801,000
                                    ==========      ========       ===========

     Utilization of the United States tax carryforwards is subject to certain
     restrictions in the event of a significant change (as defined in Internal
     Revenue Service guidelines) in ownership of the Company.

                                       36
<PAGE>
 
9.   MAJOR CUSTOMERS AND CONCENTRATION OF CREDIT RISK

     One domestic customer and one foreign licensee have each accounted for
     significant portions of the Company's revenues during the past three years.
     The percentages of total revenues derived from sales to, and royalties
     from, these major customers are as follows:

                                      1996     1995    1994

              Domestic customer       --       18%     35%
              Spanish licensee        39%      16%     18%

     The Company's domestic customer to whom sales of bovine superoxide
     dismutase ("bSOD") accounted for 18% and 35% of the Company's revenues in
     1995 and 1994, respectively, announced in the fourth quarter of 1995 that
     the clinical trial in which it was using bSOD purchased from the Company
     failed to show the desired results, and sales of bSOD to this customer have
     ceased.

     The Company limits its foreign exchange risk by buying and selling bulk
     bSOD in a single currency, the Dutch guilder. The Company maintains a bank
     account in The Netherlands for receipt and disbursement of Dutch guilders
     and had the equivalent of $1,000 and $81,000 in that account at December
     31, 1996 and 1995, respectively. Foreign currency transaction gains and
     losses were not material.


10.  GEOGRAPHIC AREA INFORMATION

     The Company operates in a single industry segment: the development,
     manufacture and marketing of therapeutic and diagnostic products. The
     Company's foreign operations consist of research and development and
     manufacturing facilities and certain marketing activities conducted by the
     Company's subsidiary in France. Sales and costs associated with bSOD
     manufactured in the Netherlands are considered to be United States
     operations, since the contract to manufacture bSOD and all related sales
     activities are administered in the United States. Similarly, royalties from
     foreign customers that relate to bSOD-based products are considered to be
     export sales from the United States, since the product was developed in the
     United States.

     Sales, operating income and identifiable assets, classified by the major
     geographic areas in which the Company operates, are as follows:

                                       37
<PAGE>
 
<TABLE>
<CAPTION>
                                                       1996           1995            1994
<S>                                                 <C>             <C>             <C>    
         Revenues from unaffiliated customers:
              United States                         $ 1,303,000     $ 2,686,000     $ 2,053,000
              Export sales from the U.S.              3,185,000       1,878,000       1,257,000
              France                                    379,000         572,000         160,000
                                                    -----------     -----------     -----------
                Total                               $ 4,867,000     $ 5,136,000     $ 3,470,000
                                                    ===========     ===========     ===========

         Operating loss:
              United States                         $(2,874,000)    $(5,653,000)    $(1,410,000)
              France                                 (3,017,000)     (3,110,000)     (4,191,000)
                                                    -----------     -----------     -----------
                Total                               $(5,891,000)    $(8,763,000)    $(5,601,000)
                                                    ===========     ===========     ===========

         Identifiable assets:
              United States                         $ 5,110,000     $ 7,824,000     $ 9,587,000
              France                                  2,942,000       3,866,000       2,570,000
              Eliminations                              (55,000)     (1,820,000)       (963,000)
                                                    -----------      ----------     -----------
                Total                               $ 7,997,000     $ 9,870,000     $11,194,000
                                                    ===========     ===========     ===========

</TABLE>

11.  LEASE COMMITMENTS

     The Company leases its facilities in Oregon under an operating lease that
     expires in 1997, and leases its facilities in France under an operating
     lease that expires in 1998. Future lease payments are scheduled as follows:

                           1997                $313,000
                           1998                 217,000

     Rental expense included in the accompanying statements of operations was
     $519,000 in 1996, $492,000 in 1995 and $193,000 in 1994.


12.  401(K) SAVINGS PLAN

     The Company has a 401(k) saving plan (the "Plan") which covers all United
     States employees who meet certain minimum age and service requirements. The
     Company's matching contribution to the Plan for each year is 100% of the
     first $1,000 of each employee's salary deferral and 33-1/3% of the next
     $3,000 of salary deferral. The Company's contributions have not been 
     material.

                                       38
<PAGE>
 
     INDEPENDENT AUDITORS' REPORT

     To the Board of Directors and Shareholders of
     OXIS International, Inc.:

     We have audited the accompanying consolidated balance sheets of OXIS
     International, Inc. and subsidiaries as of December 31, 1996 and 1995, and
     the related consolidated statements of operations, shareholders' equity and
     cash flows for each of the three years in the period ended December 31,
     1996. These financial statements are the responsibility of the management
     of OXIS International, Inc. Our responsibility is to express an opinion on
     these financial statements based on our audits.

     We conducted our audits in accordance with generally accepted auditing
     standards. Those standards require that we plan and perform the audit to
     obtain reasonable assurance about whether the financial statements are free
     of material misstatement. An audit includes examining, on a test basis,
     evidence supporting the amounts and disclosures in the consolidated
     financial statements. An audit also includes assessing the accounting
     principles used and significant estimates made by management, as well as
     evaluating the overall financial statement presentation. We believe that
     our audits provide a reasonable basis for our opinion.

     In our opinion, such consolidated financial statements present fairly, in
     all material respects, the financial position of OXIS International, Inc.
     and subsidiaries at December 31, 1996 and 1995, and the results of their
     operations and their cash flows for each of the three years in the period
     ended December 31, 1996, in conformity with generally accepted accounting
     principles.

     The accompanying financial statements for the year ended December 31, 1996,
     have been prepared assuming that the Company will continue as a going
     concern. The Company is engaged in developing, manufacturing and marketing
     selected therapeutic and diagnostic products. As discussed in Note 1 to the
     financial statements, the Company has incurred losses in each of the last
     three years, and at December 31, 1996, the Company's
     current liabilities exceeded its current assets by $1,405,000, raising
     substantial doubt about its ability to continue as a going concern.
     Management's plans concerning these matters are also described in Note 1.
     The financial statements do not include any adjustments that might result
     from the outcome of this uncertainty.


     DELOITTE & TOUCHE LLP

     March 7, 1997
     Portland, Oregon

                                       39
<PAGE>
 
ITEM 9.       CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND
              FINANCIAL DISCLOSURE.

     Not applicable.

                                    PART III

ITEM 10.  DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT.

     The information required by this item is incorporated herein by reference
     from the material contained under the caption "Proposal No. 1-Election of
     Directors" in the Company's definitive proxy statement to be filed with the
     Commission pursuant to Regulation 14A.


ITEM 11.  EXECUTIVE COMPENSATION

     The information required under this item is incorporated herein by
     reference from the material contained under the caption "Compensation of
     Executive Officers" in the Company's definitive proxy statement to be filed
     with the Commission pursuant to Regulation 14A.


ITEM 12.  SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT.

     The information required under this item is incorporated herein by
     reference from the material contained under the caption "Proposal No.
     1-Election of Directors" in the Company's definitive proxy statement to be
     filed with the Commission pursuant to Regulation 14A.


ITEM 13.  CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS.

     The information required under this item is incorporated herein by
     reference from the material contained under the caption "Proposal No.
     1-Election of Directors" in the Company's definitive proxy statement to be
     filed with the Commission pursuant to Regulation 14A.

                                       40
<PAGE>
 
                                     PART IV

ITEM 14.  EXHIBITS, FINANCIAL STATEMENT SCHEDULES AND REPORTS ON FORM 8-K.

(a)  The following documents are filed as part of this report:

     1.  FINANCIAL STATEMENTS

              See pages 16 to 39.

     2.  FINANCIAL STATEMENT SCHEDULES

              Schedules are omitted because they are not applicable or the
     required information is included in the financial statements and notes
     thereto.

     3.  EXHIBITS

              See Exhibit Index - page 43.

(b)  Reports on Form 8-K.

                                Two reports on Form 8-K were filed by the
              Company during the fourth quarter of 1996. The first, filed on
              November 4, 1996, reported the issuance of $1,000,000 in secured
              convertible term notes and the engagement of an investment banker
              to act as underwriter for a public offering of common stock on a
              French stock market. The second, filed December 30, 1996, reported
              a private placement of Series E Preferred Stock and common stock
              for an aggregate of $1,100,000.

(c)  Exhibits specified by item 601 of Regulation S-K.

         See Exhibit Index - page 43.

(d) Financial statement schedules required by Regulation S-K are omitted because
they are not applicable or the required information is included in the financial
statements and notes hereto.

                                       41
<PAGE>
 
                                   SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange
Act of 1934, the Registrant has duly caused this report to be signed on its
behalf by the undersigned, thereunto duly authorized.

Dated:  March 25, 1997


                                  OXIS INTERNATIONAL, INC.                     
                                  Registrant                                   
                
                                  By:  /s/ Anna D. Barker
                                       ---------------------------------------
                                       Anna D. Barker                          
                                       President and Chief Executive Officer   
                                         (Principal Executive Officer)         
                

                                       /s/ Jon S. Pitcher
                                       ---------------------------------------
                                       Jon S. Pitcher                          
                                       Chief Financial Officer                 
                                         (Principal Financial and 
                                          Accounting Officer)                  


Pursuant to the requirements of the Securities Exchange Act of 1934, this report
has been signed below by the following directors on behalf of the Registrant.



/s/ Anna D. Barker       March 25, 1997   /s/ Timothy G. Biro     March 25, 1997
- ---------------------------------------   --------------------------------------
Anna D. Barker           Date             Timothy G. Biro         Date



/s/ Stuart S. Lang       March 25, 1997   /s/ Gerald D. Mayer     March 25, 1997
- ---------------------------------------   --------------------------------------
Stuart S. Lang.          Date             Gerald D. Mayer         Date



/s/ James D. McCamant    March 25, 1997   /s/ David Needham       March 25, 1997
- ---------------------------------------   --------------------------------------
James D. McCamant        Date             David Needham           Date



/s/ Ray R. Rogers        March 25, 1997   /s/ A.R. Sitaraman      March 25, 1997
- ---------------------------------------   --------------------------------------
Ray R. Rogers            Date             A.R. Sitaraman          Date


                                       42
<PAGE>
 
                                  EXHIBIT INDEX
<TABLE>
<CAPTION>
                                                                                
 EXHIBIT                                                                              PAGE
 NUMBER                  DESCRIPTION OF DOCUMENT NUMBER
<S>  <C>     <C>                                                                      <C>    

2    (a)     Agreement and Plan of Reorganization and Merger between
             OXIS International, Inc., OXIS Acquisition Corporation
             and Therox Pharmaceuticals, Inc. Dated July 18, 1995                      (1)

2    (b)     Amendment No. 1 to Agreement and Plan for Reorganization
             and Merger between OXIS International, Inc., OXIS Acquisition
             Corporation and Therox Pharmaceuticals, Inc.                              (2)

3    (a)     Second Restated Certificate of Incorporation as filed
             September 10, 1996                                                         45

3    (b)     Certificate of Designations, Preferences, and Rights of Series E
             Preferred Stock of the Company                                            (3)

3    (c)     Bylaws of the Company as amended on June 15, 1994                         (4)

4    (a)     Securities Purchase Agreement, Registration Rights Agreement
             and Security Agreement                                                    (5)

10   (a)     1987 Stock Purchase Warrants                                              (6)

10   (b)     1988 Stock Purchase Warrants                                              (7)

10   (c)     Lease agreement between Bioxytech S.A. and Sofibus                        (8)

10   (d)     OXIS International, Inc. Series B Preferred Stock Purchase Agreement
             dated July 18, 1995                                                       (9)

10   (e)     Factoring (security) Agreement dated September 6, 1996 between
             Silicon Valley Financial Services and OXIS International, Inc.             77

21   (a)     Subsidiaries of OXIS International, Inc.                                   91

23   (a)     Independent Auditors' Consent                                              92

27   (a)     Financial data schedule                                                    93

</TABLE>

                                       43
<PAGE>
 
(1)  Incorporated by reference to the Company's Current Report on Form 8-K dated
     July 19, 1995.

(2)  Incorporated by reference to the Company's Annual Report on Form 10-K for 
     1995 - Exhibit 2 (b).

(3)  Incorporated by reference to the Company's Form 8-K Current Report dated
     December 30, 1996.

(4)  Incorporated by reference to the Company's Quarterly Report on Form 10-Q
     for the quarter ended June 30, 1994.

(5)  Incorporated by reference to the Company's Form 8-K Current Report dated
     November 4, 1996.

(6)  Incorporated by reference to the Company's Annual Report on Form 10-K for 
     1992 - Exhibit 10(b).

(7)  Incorporated by reference to the Company's Annual Report on Form 10-K for 
     1992 - Exhibit 10(c).

(8)  Incorporated by reference to the Company's Annual Report on Form 10-K for 
     1994.

(9)  Incorporated by reference to the Company's Quarterly Report on Form 10-Q 
     for the quarter ended September 30, 1995.

                                       44

<PAGE>
 
                                  EXHIBIT 3 (A)

                 SECOND RESTATED CERTIFICATE OF INCORPORATION OF
                            OXIS INTERNATIONAL, INC.
        UNDER SECTION 242 AND SECTION 245 OF THE GENERAL CORPORATION LAW
                            OF THE STATE OF DELAWARE


         We, RAY R. ROGERS, Chairman of the Board, and JON S. PITCHER,
Secretary, of OXIS INTERNATIONAL, INC., a Delaware corporation organized and
existing under the General Corporation Law of the State of Delaware, HEREBY
CERTIFY that:

     1.  The name of the corporation is OXIS INTERNATIONAL, INC.

     2.  The original Certificate of Incorporation was filed under the name of
         Diagnostic Data, Inc. on October 15, 1973.

     3.  On March 11, 1985, the corporation changed the name of the corporation
         to DDI Pharmaceuticals, Inc., and another name change to OXIS
         INTERNATIONAL, INC. was effected on September 7, 1994.

     4.  This Second Restated Certificate of Incorporation restates and
         integrates and further amends the provisions of the corporation's
         original Certificate of Incorporation.

     5.  This Second Restated Certificate of Incorporation has been duly adopted
         in accordance with Section 242 and Section 245 of the General
         Corporation Law of the State of Delaware and the text of such Second
         Restated Certificate of Incorporation is as follows:

                                       45
<PAGE>
 
                  SECOND RESTATED CERTIFICATE OF INCORPORATION
                                       OF
                            OXIS INTERNATIONAL, INC.


         FIRST:  The name of the corporation (hereinafter called "Company" or
"Corporation") is OXIS INTERNATIONAL, INC.

         SECOND: The registered office of the Company in the State of Delaware
is located at Corporation Trust Center, 1209 Orange Street, Wilmington, Delaware
19801, in the County of New Castle. The name of its registered agent at that
address is The Corporation Trust Company.

         THIRD: The purpose of the Company is to engage in any lawful act or
activity for which corporations may be organized under the General Corporation
Law of Delaware.

         FOURTH:

                                        I. COMMON STOCK
                                        ---------------

         The Company is authorized to issue a total of Forty Million
(40,000,000) shares of Common Stock, each of which shares of Common Stock has a
par value of Fifty Cents ($0.50). Dividends may be paid on the Common Stock as
and when declared by the Board of Directors, out of any funds of the Company
legally available for the payment of such dividends, and each share of Common
Stock will be entitled to one vote on all matters on which such stock is
entitled to vote. All duly authorized One Dollar ($1.00) par value shares
outstanding shall be deemed shares having a par value of Fifty Cents ($0.50).

                                        II. PREFERRED STOCK
                                        -------------------

         The Company is authorized to issue a total of Fifteen Million
(15,000,000) shares of Preferred Stock ($0.01 par value), each of which shares
of Preferred Stock may be issued in one or more series of stock within the class
of Preferred Stock. Each series may have such voting powers, full or limited, or
no voting powers, and such designations, preferences and relative,
participating, optional or other special rights, and qualifications, limitations
or restrictions thereof, as shall be stated and expressed in the resolution or
resolutions providing for the issue of such stock adopted by the Board of
Directors pursuant to authority hereby expressly vested in it by the provisions
of this Second Restated Certificate of Incorporation.

          A.   SERIES A PREFERRED STOCK. A series of the class of Preferred
               ------------------------- 
Stock of the Company shall be hereby created, and the shares of such series
shall be designated as "Series A Preferred Stock." The number of shares of the
class of Preferred Stock shall be 100,000, and the preferences and rights of the
shares of such series shall be the same as the rights of the shares of Common
Stock of the Company except that the shares of such series shall have no voting
power and that in the event of any liquidation, dissolution, or winding up of
the Company, the holders of the Series A Preferred Stock shall be entitled to
receive prior to and in preference to any 

                                       46
<PAGE>
 
distribution of any assets or surplus funds of the Company to the holders of
Common Stock by reason of their ownership thereof, the amount of $.01 per share.
If at any time and from time to time any holder of shares of Series A Preferred
Stock owns less than 4.99% of the then outstanding shares of the Common Stock of
the Company, a portion of such holder's shares of Series A Preferred Stock shall
automatically convert into shares of the Company's Common Stock (on the basis of
one share of Series A Preferred Stock converting into one fully paid and
nonassessable share of Common Stock of the Company) until such holder owns 4.99%
of the then outstanding shares of the Company's Common Stock.

          B.   SERIES B PREFERRED STOCK. A series of the class of Preferred
          ------------------------------
Stock of the Company shall be hereby created, and the shares of such series
shall be designated as "Series B Preferred Stock", par value $0.01 per share.
The number of shares constituting such series shall be 642,583 and the rights,
preferences, privileges and restrictions granted to or imposed upon the Series B
Preferred Stock are as follows:

               1. Series B Dividends.
                  -------------------
                  (a) The holders of outstanding Series B Preferred Stock shall
be entitled to receive in any fiscal year, when, as and if declared by the Board
of Directors, out of any assets at the time legally available therefor,
dividends at the rate of $0.115 per share of Series B Preferred Stock per annum
before any dividend or distribution (other than pursuant to Section B.4) is paid
on Common Stock. Such dividend or distribution may be payable annually or
otherwise as the Board of Directors may from time to time determine. Dividends
or distributions (other than dividends payable solely in shares of Common Stock
or distributions pursuant to Section B.4) of up to $0.115 per share may be
declared and paid upon shares of Common Stock in any fiscal year of the
Corporation only if dividends shall have been paid on and declared and set apart
upon all shares of Series B Preferred Stock at such annual rate in such year.
After dividends or distributions of $0.115 per share have been declared and paid
on the Common Stock in any fiscal year, all further dividends and distributions
during such fiscal year shall be distributed among the holders of the Common
Stock and the Series B Preferred Stock in proportion to the shares of Common
Stock then held by them and the shares of Common Stock which they then have the
right to acquire upon conversion of the shares of Series B Preferred Stock then
held by them. The right to such dividends on shares of Series B Preferred Stock
shall not be cumulative and no right shall accrue to holders of shares of Series
B Preferred Stock by reason of the fact that dividends on said shares are not
declared in any prior year, nor shall any undeclared or unpaid dividend bear or
accrue interest.

               2. Series B Voting Rights.
                  -----------------------
                  (a) Each holder of shares of Series B Preferred Stock shall be
entitled to the number of votes equal to the number of shares of Common Stock
into which such holder's shares of Series B Preferred Stock could be converted
on the record date for the vote or consent of stockholders and, except as
otherwise provided herein, shall have voting rights and powers equal to the
voting rights and powers of the Common Stock. The holder of each share of Series
B Preferred Stock shall be entitled to notice of any stockholders' meeting in
accordance with the

                                       47
<PAGE>
 
Bylaws of the Corporation and shall vote with holders of the Common Stock upon
the election of directors and upon any other matter submitted to a vote of
stockholders, except those matters required by law to be submitted to a class or
series vote and except as otherwise provided in Section B.2(b)hereof. Fractional
votes by the holders of Series B Preferred Stock shall not, however, be
permitted and any fractional voting rights resulting from the above formula
(after aggregating all shares into which shares of Series B Preferred Stock held
by each holder could be converted) shall be rounded to the nearest whole number.

                  (b) The number of directors shall be set as provided in the
Bylaws of the Corporation. So long as any shares of Series B Preferred Stock
remain outstanding, the holders of the Series B Preferred Stock outstanding
shall vote together with the Common Stock as a single class with respect to the
election of directors.

               3. Series B Conversion. The holders of Series B Preferred Stock
                  -------------------
shall have conversion rights as follows (the "Conversion Rights");

                  (a) Right to Convert. Each share of Series B Preferred Stock
                      ---------------- 
shall be convertible, at the option of the holder thereof, at any time after the
date of issuance of such share at the office of the Corporation or any transfer
agent for such stock, into such number of fully paid and nonassessable shares of
Common Stock as is determined by dividing $2.33433 by the Series B Conversion
Price, determined as hereinafter provided, in effect on the date the certificate
is surrendered for conversion. The price at which shares of Common Stock shall
be deliverable upon conversion of shares of the Series B Preferred Stock (the
"Series B Conversion Price") shall initially be $2.33433 per share of Common
Stock. Such initial Series B Conversion Price shall be adjusted as hereinafter
provided.

                  (b) Automatic Conversion. Each share of Series B Preferred
                      --------------------
Stock shall automatically be converted into such number of fully paid and
nonassessable shares of Common Stock as is determined by dividing $2.33433 by
the Series B Conversion Price, in effect on the date of the receipt by the
Corporation of the written consent to, or request for, such conversion from
holders of at least three-fourths (3/4) of the Series B Preferred Stock then
outstanding.

                  (c) Mechanics of Conversion.
                      -----------------------
                      (i) Before any holder of Series B Preferred Stock shall
be entitled to convert the same into shares of Common Stock, he shall surrender
the certificate or certificates therefor, duly endorsed, at the office of the
Corporation or of any transfer agent for such stock, and shall give written
notice to the Corporation at such office that he elects to convert the same and
shall state therein the name or names in which he wishes the certificate or
certificates for shares of Common Stock to be issued. The Corporation shall, as
soon as practicable thereafter, issue and deliver at such office to such holder
of Series B Preferred Stock, a certificate or certificates for the number of
shares of Common Stock to which he shall be entitled as aforesaid. Such
conversion shall be deemed to have been made immediately prior to the close of
business on the date of surrender of the shares of Series B Preferred Stock to
be converted, and the person or persons entitled to receive the shares of Common
Stock issuable
                                       48
<PAGE>
 
upon such conversion shall be treated for all purposes as the record holder or
holders of such shares of Common Stock on such date.

                      (ii) If a voluntary conversion is made in connection
with an underwritten offering of securities pursuant to a registration statement
filed pursuant to the Securities Act of 1933, as amended (the "Securities Act"),
the conversion may, at the option of any holder tendering shares of Series B
Preferred Stock for conversion, be conditioned upon the closing with the
underwriters of the sale of securities pursuant to such offering, in which event
the person(s) entitled to receive the Common Stock upon conversion of the Series
B Preferred Stock shall not be deemed to have converted such Series B Preferred
Stock until immediately prior to the closing of such sale of securities.

                  (d) Adjustments for Stock Dividends, Subdivisions, or Split-
                      ---------------------------------------------------------
ups of Common Stock. If the number of shares of Common Stock outstanding at any
- --------------------
time after the filing of the original Certificate of Designation with respect to
the Series B Preferred Stock (July 19, 1995) is increased by a stock dividend
payable in shares of Common Stock or by a subdivision or split-up of shares of
Common Stock, then, effective at the close of business upon the record date
fixed for the determination of holders of Common Stock entitled to receive such
stock dividend, subdivision or split-up, the Conversion Price for the Series B
Preferred Stock shall be appropriately decreased so that the number of shares of
Common Stock issuable on conversion of each share of Series B Preferred Stock
shall be increased in proportion to such increase of outstanding shares of
Common Stock.

                  (e) Adjustments for Combinations of Common Stock. If the
                      --------------------------------------------
number of shares of Common Stock outstanding at any time after the filing of the
original Certificate of Designation with respect to the Series B Preferred Stock
(July 19, 1995) is decreased by a combination of the outstanding shares of
Common Stock, then, effective at the close of business upon the record date of
such combination, the Conversion Price for the Series B Preferred Stock shall be
appropriately increased so that the number of shares of Common Stock issuable on
conversion of each share of Series B Preferred Stock shall be decreased in
proportion to such decrease in outstanding shares of Common Stock.

                  (f) Adjustments for Other Distributions. In the event the
                      -----------------------------------
Corporation at any time or from time to time makes, or fixes a record date for
the determination of holders of Common Stock entitled to receive any
distribution payable in securities of the Corporation other than shares of
Common Stock, then and in each such event provision shall be made so that the
holders of Series B Preferred Stock shall receive upon conversion thereof, in
addition to the number of shares of Common Stock receivable thereupon, the
amount of securities of the Corporation which they would have received had their
Series B Preferred Stock been converted into Common Stock on the date of such
event and had they thereafter, during the period from the date of such event to
and including the date of conversion, retained such securities receivable by
them as aforesaid during such period, subject to all other adjustments called
for during such period under this Section B.3(f) with respect to the rights of
the holders of the Series B Preferred Stock.

                                       49
<PAGE>
 
                  (g) Adjustments for Reorganizations, Reclassifications, etc.
                      --------------------------------------------------------
If the Common Stock issuable upon conversion of the Series B Preferred Stock
shall be changed into the same or a different number of shares of any other
class or classes of stock or other securities or property, whether by
reclassification, a merger or consolidation of this Corporation with or into any
other corporation or corporations, or a sale of all or substantially all of the
assets of this Corporation, or otherwise, the Conversion Price then in effect
shall, concurrently with the effectiveness of such reorganization or
reclassification, be proportionately adjusted such that the Series B Preferred
Stock shall be convertible into, in lieu of the number of shares of Common Stock
which the holders would otherwise have been entitled to receive, a number of
shares of such other class or classes of stock or securities or other property
equivalent to the number of shares of Common Stock that would have been subject
to receipt by the holders upon conversion of the Series B Preferred Stock
immediately before such event; and, in any such case, appropriate adjustment (as
determined by the Board) shall be made in the application of the provisions
herein set forth with respect to the rights and interests thereafter of the
holders of the Series B Preferred Stock, to the end that the provisions set
forth herein (including provisions with respect to changes in and other
adjustments of the Conversion Price) shall thereafter be applicable, as nearly
as may be reasonable, in relation to any shares of stock or other property
thereafter deliverable upon the conversion of the Series B Preferred Stock.

                  (h) Certificates as to Adjustments. Upon the occurrence of
                      ------------------------------
each adjustment or readjustment of the Series B Conversion Price pursuant to
this Section B.3, the Corporation at its expense shall promptly compute such
adjustment or readjustment in accordance with the terms hereof and prepare and
furnish to each holder of Series B Preferred Stock a certificate executed by the
Corporation's President or Chief Financial Officer setting forth such adjustment
or readjustment and showing in detail the facts upon which such adjustment or
readjustment is based. The Corporation shall, upon the written request at any
time of any holder of Series B Preferred Stock, furnish or cause to be furnished
to such holder a like certificate setting forth (A) such adjustments and
readjustments, (B) the Conversion Price for such Series B Preferred Stock at the
time in effect, and (C) the number of shares of Common Stock and the amount, if
any, of other property which at the time would be received upon the conversion
of the Series B Preferred Stock.

                  (i) Notices of Record Date. In the event that the Corporation
                      ----------------------
shall propose at any time: (a) to declare any special dividend or distribution
upon its Common Stock, whether in cash, property, stock or other securities,
whether or not out of earnings or earned surplus; (b) to offer for subscription
pro rata to the holders of any class or series of its stock any additional
shares of stock of any class or series or other rights; (c) to effect any
reclassification or recapitalization of its Common Stock outstanding involving a
change in the Common Stock; or (d) to merge or consolidate with or into any
other corporation (other than a mere reincorporation transaction), or sell,
lease or convey all or substantially all of its assets, or to liquidate,
dissolve or wind up; then, in connection with each such event, the Corporation
shall send to the holders of Series B Preferred Stock:

                      (i) at least twenty (20) days' prior written notice of
the date on which a record shall be taken for such dividend, distribution or
subscription rights (and 

                                       50
<PAGE>
 
specifying the date on which the holders of Common Stock shall be entitled
thereto) or for determining rights to vote, if any, in respect of the matters
referred to in (c) and (d) above; and

                      (ii) In the case of the matters referred to in (c) and (d)
above, at least twenty (20) days' prior written notice of the date when the same
shall take place (and specifying the date on which the holders of Common Stock
shall be entitled to exchange their Common Stock for securities or other
property deliverable upon the occurrence of such event).

                  (j) Reservation of Stock Issuable Upon Conversion. The
                      ----------------------------------------------
Corporation shall at all times reserve and keep available out of its authorized
but unissued shares of Common Stock, solely for the purpose of effecting the
conversion of the shares of the Series B Preferred Stock, such number of its
shares of Common Stock as shall from time to time be sufficient to effect the
conversion of all outstanding shares of the Series B Preferred Stock; and if at
any time the number of authorized but unissued shares of Common Stock shall not
be sufficient to effect the conversion of all then outstanding shares of the
Series B Preferred Stock, the Corporation will take such corporate action as
may, in the opinion of its counsel, be necessary to increase its authorized but
unissued shares of Common Stock to such number of shares as shall be sufficient
for such purpose, including, without limitation, engaging in its best efforts to
obtain the requisite stockholder approval of any necessary amendment to the
Certificate of Incorporation.

                  (k) Fractional Shares. No fractional share shall be issued
                      ------------------
upon the conversion of any share or shares of Series B Preferred Stock. All
shares of Common Stock (including fractions thereof) issuable upon conversion of
more than one share of Series B Preferred Stock by a holder thereof shall be
aggregated for purposes of determining whether the conversion would result in
the issuance of any fractional share. If, after the aforementioned aggregation,
the conversion would result in the issuance of a fraction of a share of Common
Stock, the Corporation shall, in lieu of issuing any fractional share, pay the
holder otherwise entitled to such fraction a sum in cash equal to the fair
market value of such fraction on the date of conversion (as determined in good
faith by the board of directors of the Corporation).

                  (l) Notices. Any notice required by the provisions of this
                      --------
Section B.3 to be given to the holders of shares of Series B Preferred Stock
shall be deemed given on the date of delivery if delivered by hand delivery or
by facsimile, or, if deposited in the United States mail (registered or
certified), postage prepaid, and addressed to each holder of record at his or
its address appearing on the books of the Corporation.

               4. Series B Liquidation Preferences.
                  ---------------------------------

                  (a) In the event of any liquidation, dissolution or winding up
of the Corporation whether voluntary or involuntary, the holders of the Series B
Preferred Stock shall be entitled to receive, prior and in preference to any
distribution of any of the assets or surplus funds of the Corporation to the
holders of Common Stock or any other shares of this corporation other than
Series B Preferred Stock by reason of their ownership thereof, the amount of
$2.33433 per share (as adjusted for any stock dividends, combinations or splits
with respect to such shares), plus all declared or accrued but unpaid, dividends
on such share, for each share of Series B Preferred Stock then held by them. If
upon the occurrence of such event, the assets and funds

                                       51
<PAGE>
 
thus distributed among the holders of the Series B Preferred Stock shall be
insufficient to permit the payment to such holders of the full aforesaid
preferential amount, then the entire assets and funds of the Corporation legally
available for distribution shall be distributed ratably among the holders of the
Series B Preferred Stock in proportion to the preferential amount each such
holder is otherwise entitled to receive.

                  (b) After the payment to the holders of the Series B Preferred
Stock of the amounts set forth in Section B.4(a) above, the holders of the
Common Stock shall be entitled to receive, prior and in preference to any
distribution of any of the assets or surplus funds of the Corporation to the
holders of the other capital stock of the Company by reason of their ownership
thereof, an aggregate distribution equal to the total consideration received by
the Corporation for the sale and issuance of all issued and outstanding Series B
Preferred Stock, with each holder of Common Stock participating on a pro rata
basis based on the number of shares of Common Stock they own. If upon the
occurrence of such event, the assets and funds thus distributed among the
holders of the Common Stock shall be insufficient to permit the payment to such
holders of the full aforesaid preferential amount, then all assets and funds of
the Corporation legally available for distribution after the payment to the
holders of the Series B Preferred Stock of the amounts set forth in Section
B.4(a) shall be distributed ratably among the holders of the Common Stock in
proportion to the preferential amount each such holder is otherwise entitled to
receive.

                  (c) After payments to (i) the holders of the Series B
Preferred Stock of the amounts set forth in Section B.4(a) above, and (ii) the
holders of the Common Stock of the amounts set forth in Section B.4(b) above,
the entire remaining assets and funds of the Corporation legally available for
distribution, if any, shall be distributed among the holders of the Common Stock
and the Series B Preferred Stock in proportion to the shares of Common Stock
then held by them and the shares of Common Stock which they then have the right
to acquire upon conversion of the shares of Series B Preferred Stock then held
by them.

               5. Series B Protective Provisions. In addition to any other
                  -------------------------------
rights provided by law, so long as any share of Series B Preferred Stock shall
be outstanding, the Corporation shall not, without first obtaining the
affirmative vote or written consent of the holders of the majority of the
outstanding shares of Series B Preferred Stock voting separately as a separate
class, take any action which alters or changes any of the rights, privileges or
preferences of the Series B Preferred Stock, including without limitation
increasing or decreasing the aggregate number of authorized shares of such
series other than an increase incident to a stock split.

           C.  SERIES C PREFERRED STOCK. A series of the class of Preferred
               -------------------------
Stock of the Company shall be hereby created, and the shares of such series
shall be designated as "Series C Preferred Stock", par value $0.01 per share.
The number of shares constituting such series shall be 3,076,923 and the rights,
preferences, privileges and restrictions granted to or imposed upon the Series C
Preferred Stock are as follows:

               1. Series C Dividends.
                  -------------------

                                       52
<PAGE>
 
                  (a) The holders of outstanding Series C Preferred Stock shall
be entitled to receive in any fiscal year, when, as and if declared by the Board
of Directors, after the payment of dividends on Series B Preferred Stock, out of
any assets at the time legally available therefor, dividends in amounts
determined by the Corporation's Board of Directors before any other dividend or
distribution (other than pursuant to Section C.4, or distributions with respect
to the Series B Preferred Stock) is paid on Common Stock. Such dividend or
distribution may be payable annually or otherwise as the Board of Directors may
from time to time determine. The right to such dividends on shares of Series C
Preferred Stock shall not be cumulative and no right shall accrue to holders of
shares of Series C Preferred Stock by reason of the fact that dividends on said
shares are not declared in any prior year, nor shall any undeclared or unpaid
dividend bear or accrue interest.

               2. Series C Voting Rights. Each holder of shares of Series C
                  -----------------------  
Preferred Stock shall be entitled to the number of votes equal to the number of
shares of Common Stock into which such holder's shares of Series C Preferred
Stock could be converted on the record date for the vote or consent of
stockholders multiplied by the Voting Power Fraction and, except as otherwise
provided herein, shall have voting rights and powers equal to the voting rights
and powers of the Common Stock. The Voting Power Fraction shall equal $1.30
divided by the average closing bid price of the Company's Common Stock during
the 15 consecutive trading days immediately prior to the date the Series C
Preferred was purchased (the "Average Closing Price"); but in no event shall be
greater than one (1). The holder of each share of Series C Preferred Stock shall
be entitled to notice of any stockholders' meeting in accordance with the Bylaws
of the Corporation and shall vote with holders of the Common Stock upon the
election of directors and upon any other matter submitted to a vote of
stockholders, except those matters required by law to be submitted to a class or
series vote. Fractional votes by the holders of Series C Preferred Stock shall
not, however, be permitted and any fractional voting rights resulting from the
above formula (after aggregating all shares into which shares of Series C
Preferred Stock held by each holder could be converted) shall be rounded to the
nearest whole number.

               3. Series C Conversion. The holders of Series C Preferred Stock
                  --------------------
shall have conversion rights as follows (the "Conversion Rights"):

                  (a) Right to Convert. Each share of Series C Preferred Stock
shall be convertible, at the option of the holder thereof, at any time after the
date of issuance of such share at the office of the Corporation or any transfer
agent for such stock, into such number of fully paid and nonassessable shares of
Common Stock as is determined by dividing $1.30 by the Series C Conversion
Price, determined as hereinafter provided, in effect on the date the certificate
is surrendered for conversion. The Series C Conversion Price shall initially be
$1.30. Such initial Series C Conversion Price shall be adjusted as hereinafter
provided.

                  (b) Mechanics of Conversion.
                      ------------------------

                      (i) Before any holder of Series C Preferred Stock shall be
entitled to convert the same into shares of Common Stock, he shall surrender the
certificate or certificates therefor, duly endorsed, at the office of the
Corporation or of any transfer agent for

                                       53
<PAGE>
 
such stock, and shall give written notice to the Corporation at such office that
he elects to convert the same and shall state therein the name or names in which
he wishes the certificate or certificates for shares of Common Stock to be
issued. The Corporation shall, as soon as practicable thereafter, issue and
deliver at such office to such holder of Series C Preferred Stock, a certificate
or certificates for the number of shares of Common Stock to which he shall be
entitled as aforesaid. Such conversion shall be deemed to have been made
immediately prior to the close of business on the date of surrender of the
shares of Series C Preferred Stock to be converted, and the person or persons
entitled to receive the shares of Common Stock issuable upon such conversion
shall be treated for all purposes as the record holder or holders of such shares
of Common Stock on such date.

                      (ii) If a voluntary conversion is made in connection with
an underwritten offering of securities pursuant to a registration statement
filed pursuant to the Securities Act of 1933, as amended (the "Securities Act"),
the conversion may, at the option of any holder tendering shares of Series C
Preferred Stock for conversion, be conditioned upon the closing with the
underwriters of the sale of securities pursuant to such offering, in which event
the person(s) entitled to receive the Common Stock upon conversion of the Series
C Preferred Stock shall not be deemed to have converted such Series C Preferred
Stock until immediately prior to the closing of such sale of securities.

                  (c) Adjustments for Stock Dividends, Subdivisions, or Split-
                      --------------------------------------------------------
ups of Common Stock. If the number of shares of Common Stock outstanding at any
- --------------------
time after the filing of the original Certificate of Designation with respect to
the Series C Preferred Stock (February 8, 1996) is increased by a stock dividend
payable in shares of Common Stock or by a subdivision or split-up of shares of
Common Stock, then, effective at the close of business upon the record date
fixed for the determination of holders of Common Stock entitled to receive such
stock dividend, subdivision or split-up, the Series C Conversion Price shall be
appropriately decreased so that the number of shares of Common Stock issuable on
conversion of each share of Series C Preferred Stock shall be increased in
proportion to such increase of outstanding shares of Common Stock.

                  (d) Adjustments for Combinations of Common Stock. If the
                      ---------------------------------------------
number of shares of Common Stock outstanding at any time after the filing of the
original Certificate of Designation with respect to the Series C Preferred Stock
(February 8, 1996) is decreased by a combination of the outstanding shares of
Common Stock, then, effective at the close of business upon the record date of
such combination, the Series C Conversion Price shall be appropriately increased
so that the number of shares of Common Stock issuable on conversion of each
share of Series C Preferred Stock shall be decreased in proportion to such
decrease in outstanding shares of Common Stock.

                  (e) Adjustments for Other Distributions. In the event the
                      ------------------------------------ 
Corporation at any time or from time to time makes, or fixes a record date for
the determination of holders of Common Stock entitled to receive any
distribution payable in securities of the Corporation other than shares of
Common Stock, then and in each such event provision shall be made so that the
holders of Series C Preferred Stock shall receive upon conversion thereof, in
addition to the

                                       54
<PAGE>
 
number of shares of Common Stock receivable thereupon, the amount of securities
of the Corporation which they would have received had their Series C Preferred
Stock been converted into Common Stock on the date of such event and had they
thereafter, during the period from the date of such event to and including the
date of conversion, retained such securities receivable by them as aforesaid
during such period, subject to all other adjustments called for during such
period under this Section C.3(e) with respect to the rights of the holders of
the Series C Preferred Stock.

                   (f) Adjustments for Reorganizations, Reclassifications, etc.
                       -------------------------------------------------------  
If the Common Stock issuable upon conversion of the Series C Preferred Stock
shall be changed into the same or a different number of shares of any other
class or classes of stock or other securities or property, whether by
reclassification, a merger or consolidation of this Corporation with or into any
other corporation or corporations, or a sale of all or substantially all of the
assets of this Corporation, or otherwise, the Series C Conversion Price then in
effect shall, concurrently with the effectiveness of such reorganization or
reclassification, be proportionately adjusted such that the Series C Preferred
Stock shall be convertible into, in lieu of the number of shares of Common Stock
which the holders would otherwise have been entitled to receive, a number of
shares of such other class or classes of stock or securities or other property
equivalent to the number of shares of Common Stock that would have been subject
to receipt by the holders upon conversion of the Series C Preferred Stock
immediately before such event; and, in any such case, appropriate adjustment (as
determined by the Board) shall be made in the application of the provisions
herein set forth with respect to the rights and interests thereafter of the
holders of the Series C Preferred Stock, to the end that the provisions set
forth herein (including provisions with respect to changes in and other
adjustments of the Series C Conversion Price) shall thereafter be applicable, as
nearly as may be reasonable, in relation to any shares of stock or other
property thereafter deliverable upon the conversion of the Series C Preferred
Stock.

                   (g) Certain Other Adjustment. If at any time after six (6)
                       ------------------------
months following the consummation ("Closing") of the sale of Series C Preferred
Stock purchased pursuant to those certain Subscription and Purchase Agreements
between the Corporation and each holder of such Series C Preferred Stock (such
Closing having occurred on May 9, 1996), any such holder converts the Series C
Preferred Stock, then the Series C Conversion Price applicable to such holder's
shares shall be the lesser of (i) $1.30, or (ii) the greater of (x) .90 or (y)
80% of the average closing bid price of the Common Stock for the fifteen (15)
consecutive trading days ending on the date immediately preceding the date
notice of conversion is given. The Series C Conversion Price may only adjust
once for each holder.

                   (h) Company's Right to Automatically Convert. If at any time
                       ----------------------------------------
after eight (8) months following the Closing the average closing bid price of
the Corporation's Common Stock for 15 consecutive trading days as quoted on the
Nasdaq National Market is equal to or greater than $2.60, the Corporation shall
thereafter have the right to automatically convert the Series C Preferred Stock
into such number of shares of Common Stock as is determined by dividing $1.30 by
the then applicable Series C Conversion Price by notice given to such holders of
Series C Preferred Stock.

                                       55
<PAGE>
 
                  (i) Certificates as to Adjustments. Upon the occurrence of
                      ------------------------------
each adjustment of the Series C Conversion Price pursuant to this Section C.3,
the Corporation at its expense shall promptly compute such adjustment in
accordance with the terms hereof and prepare and furnish to each applicable
holder of Series C Preferred Stock a certificate executed by the Corporation's
President or Chief Financial Officer setting forth such computation of
adjustment.

                  (j) Notices of Record Date. In the event that the Corporation
                      ----------------------
shall propose at any time: (a) to declare any special dividend or distribution
upon its Common Stock, whether in cash, property, stock or other securities,
whether or not out of earnings or earned surplus; (b) to offer for subscription
pro rata to the holders of any class or series of its stock any additional
shares of stock of any class or series or other rights; (c) to effect any
reclassification or recapitalization of its Common Stock outstanding involving a
change in the Common Stock; or (d) to merge or consolidate with or into any
other corporation (other than a mere reincorporation transaction), or sell,
lease or convey all or substantially all of its assets, or to liquidate,
dissolve or wind up; then, in connection with each such event, the Corporation
shall send to the holders of Series C Preferred Stock:

                      (i) at least twenty (20) days' prior written notice of the
date on which a record shall be taken for such dividend, distribution or
subscription rights (and specifying the date on which the holders of Common
Stock shall be entitled thereto) or for determining rights to vote, if any, in
respect of the matters referred to in (c) and (d) above; and

                      (ii) in the case of the matters referred to in (c) and (d)
above, at least twenty (20) days' prior written notice of the date when the same
shall take place (and specifying the date on which the holders of Common Stock
shall be entitled to exchange their Common Stock for securities or other
property deliverable upon the occurrence of such event).

                  (k) Reservation of Stock Issuable Upon Conversion. The
                      --------------------------------------------- 
Corporation shall at all times reserve and keep available out of its authorized
but unissued shares of Common Stock, solely for the purpose of effecting the
conversion of the shares of the Series C Preferred Stock, such number of its
shares of Common Stock as shall from time to time be sufficient to effect the
conversion of all outstanding shares of the Series C Preferred Stock; and if at
any time the number of authorized but unissued shares of Common Stock shall not
be sufficient to effect the conversion of all then outstanding shares of the
Series C Preferred Stock, the Corporation will take such corporate action as
may, in the opinion of its counsel, be necessary to increase its authorized but
unissued shares of Common Stock to such number of shares as shall be sufficient
for such purpose, including, without limitation, engaging in its best efforts to
obtain the requisite stockholder approval of any necessary amendment to the
Certificate of Incorporation.

                  (l) Fractional Shares. No fractional share shall be issued
                      -----------------
upon the conversion of any share or shares of Series C Preferred Stock. All
shares of Common Stock (including fractions thereof) issuable upon conversion of
more than one share of Series C Preferred Stock by a holder thereof shall be
aggregated for purposes of determining whether the conversion would result in
the issuance of any fractional share. If, after the aforementioned

                                       56
<PAGE>
 
aggregation, the conversion would result in the issuance of a fraction of a
share of Common Stock, the Corporation shall, in lieu of issuing any fractional
share, pay the holder otherwise entitled to such fraction a sum in cash equal to
the fair market value of such fraction on the date of conversion (as determined
in good faith by the board of directors of the Corporation).

                  (m) Notices. Any notice required by the provisions of this
                      ------- 
Section C.3 to be given to the holders of shares of Series C Preferred Stock
shall be deemed given on the date of delivery if delivered by hand delivery or
by facsimile, or, if deposited in the United States mail (registered or
certified), postage prepaid, and addressed to each holder of record at his or
its address appearing on the books of the Corporation.

              4.  Series C Liquidation Preferences. In the event of any
                  --------------------------------
liquidation, dissolution or winding up of the Corporation whether voluntary or
involuntary, the holders of the Series C Preferred Stock shall participate on an
equal basis with the holders of the Common Stock (as if the Series C Preferred
Stock had converted into Common Stock) in any distribution of any of the assets
or surplus funds of the Corporation.

              5.  Series C Protective Provisions. In addition to any other
                  ------------------------------ 
rights provided by law, so long as any share of Series C Preferred Stock shall
be outstanding, the Corporation shall not, without first obtaining the
affirmative vote or written consent of the holders of the majority of the
outstanding shares of Series C Preferred Stock voting separately as a separate
class, take any action which alters or changes any of the rights, privileges or
preferences of the Series C Preferred Stock, including without limitation
increasing or decreasing the aggregate number of authorized shares of such
series other than an increase incident to a stock split.

          D.  SERIES D PREFERRED STOCK. A series of the class of Preferred Stock
              ------------------------ 
of the Company shall be hereby created, and the shares of such series shall be
designated as "Series D Preferred Stock", par value $0.01 per shares. The number
of shares constituting such series shall be 2,000 and the stated value shall be
One Thousand Dollars ($1,000) per share (the "Stated Value").

              1. Rank With Respect to Liquidation Event. In the event of any
                 -------------------------------------- 
distribution of assets upon liquidation, dissolution or winding up of the
Corporation, whether voluntary or involuntary, the holders of Series D Preferred
Stock shall participate on an equal basis with (i) the holders of the
Corporation's Common Stock, par value $.50 per share (the "Common Stock"), as if
the Series D Preferred Stock had converted into Common Stock; (ii) the holders
of the Corporation's Series C Preferred Stock, par value $.01 per share (the
"Series C Preferred Stock"); and (iii) the holders of any class or series of
capital stock of the Corporation hereafter created (with the consent of the
holders of Series D Preferred Stock obtained in accordance with Section 7
hereof) which specifically, by its terms, ranks pari passu with the Series D
Preferred Stock (collectively, with the Common Stock and the Series C Preferred
Stock, "Pari Passu Securities").

              2. No Dividends,
                 ------------

                                       57
<PAGE>
 
         The Series D Preferred Stock will bear no dividends, and the holders of
the Series D Preferred Stock shall not be entitled to receive dividends on the
Series D Preferred Stock.

               3. Cash Redemption of Premium by Corporation; Redemption of
                  --------------------------------------------------------
Series D Preferred Stock.
- ------------------------
                  
                  (a) The Corporation shall have the right, in its sole
discretion, upon receipt of a Notice of Conversion pursuant to Section 4(d) or
in the event of a Mandatory Conversion effected in accordance with Section 5
hereof, to redeem all or any portion of the Premium (as defined in Section 4(a)
below) subject to such conversion for a sum of cash equal to the amount of the
Premium being so redeemed. All cash redemption payments hereunder shall be paid
in lawful money of the United States of America at such address for the holder
as appears on the record books of the Corporation (or at such other address as
such holder shall hereafter give to the Corporation by written notice). In the
event the Corporation elects, pursuant to this Section 3(a), to redeem all or
any portion of the Premium in cash and fails to pay such holder the applicable
redemption amount to which such holder is entitled by depositing a check in the
U.S. Mail to such holder within seven (7) business days of receipt by the
Corporation of a Conversion Notice (in the case of a redemption in connection
with an Optional Conversion) or May 15, 2001 (in the case of a redemption in
connection with a Mandatory Conversion), the Corporation shall thereafter
forfeit its right to redeem such Premium in cash and such Premium shall
thereafter be converted into shares of Common Stock in accordance with Section 4
hereof.

                  (b) Each holder of Series D Preferred Stock shall have the
right to require the Corporation to provide advance notice to such holder
stating whether the Corporation will elect to redeem all or any portion of the
Premium in cash pursuant to the Corporation's redemption rights discussed in
Section D.3(a) as set forth herein. A holder may exercise such right from time
to time by sending notice (an "Election Notice") to the Corporation, by
facsimile, requesting that the Corporation disclose to such holder whether the
Corporation would elect to redeem any portion of the Premium for cash in lieu of
issuing Common Stock in accordance with Section 4 hereof if such holder were to
exercise his, her or its right of conversion pursuant to Section 4. The
Corporation shall, no later than the fifth (5th) business day following receipt
of an Election Notice, disclose to such holder, whether the Corporation would
elect to redeem any portion of a Premium in connection with a conversion
pursuant to a Conversion Notice delivered over the subsequent ten (10) business
day period. If the Corporation does not respond to such holder within such five
(5) business day period via facsimile, the Corporation shall, with respect to
any conversion pursuant to a Conversion Notice delivered within the subsequent
ten (10) business day period, forfeit its right to redeem such Premium in
accordance with Section D.3(a) and shall be required to convert such Premium
into shares of Common Stock in accordance with Section 4 hereof.

                  (c) Except as provided in Section D.3 and Section D.4 hereof,
the Series D Preferred Stock is not subject to redemption.

                  (d) Commencing May 15, 1998, at any time that the average of
the closing bid prices for the Common Stock on NASDAQ, or on the principal
securities exchange

                                       58
<PAGE>
 
or other securities market on which the Common Stock is being traded, for the
twenty (20) consecutive Trading Days ending one Trading Day prior to the date
the Corporation provides the holders a Redemption Notice (as defined herein)
under this Section D.3 is equal to or greater than 200% of the closing bid price
for the Common Stock on NASDAQ (or on the principal securities exchange or other
securities market on which the Common Stock is being traded) on the Closing Date
(as defined herein) (the "Optional Redemption Threshold Price"), the Corporation
shall have the right, in its sole discretion, to redeem ("Redemption at
Corporation's Election") any or all of the Series D Preferred Stock at the
Redemption Price (as defined herein), in accordance with the redemption
procedures set forth below; provided, however, that if the average closing bid
price of the Common Stock for any ten (10) consecutive Trading Days after a
Redemption Notice is less than 75% of the Optional Redemption Threshold Price,
the Corporation's Redemption Notice shall thereafter be rendered null and void
and the Corporation shall not have the right to redeem the Series D Preferred
Stock pursuant to the terms of this Section D.3 unless and until it delivers
another Redemption Notice to the holders of the Series D Preferred Stock in
accordance with the provisions of this Section D.3. "Trading Day" shall mean any
day on which the Common Stock is traded for any period on NASDAQ, or on the
principal securities exchange or other securities market on which the Common
Stock is then being traded. If the Corporation elects to redeem some, but not
all, of the Series D Preferred Stock, the Corporation shall redeem a pro-rata
amount from each holder of Series D Preferred Stock. Holders of Series D
Preferred Stock may convert all or any part of their shares of Series D
Preferred Stock into Common Stock by delivering a Notice of Conversion (as
defined herein) to the Corporation at any time prior to the Effective Date of
Redemption (as defined herein).

                  (e) The "Redemption Price" with respect to each share of
Series D Preferred Stock shall mean the amount equal to the sum of (i) the
Stated Value thereof plus (ii) the amount equal to eight (8%) percent per annum
of such Stated Value for the period beginning on the issuance of such share and
ending on the Effective Date of Redemption hereunder.

                  (f) The Corporation shall effect each redemption under this
Section D.3 by giving at least ninety (90) days (subject to extension as set
forth below) prior written notice (the "Redemption Notice") to (i) the holders
of Series D Preferred Stock selected for redemption at the address and facsimile
number of such holder appearing in the Corporation's register for the Series D
Preferred Stock and (ii) the Transfer Agent, which Redemption Notice shall be
deemed to have been delivered three (3) business days after the Corporation's
mailing (by overnight courier, with a copy by facsimile) of such notice. Such
Redemption Notice shall indicate the number of shares of the holder's Series D
Preferred Stock that have been selected for redemption, the date which such
redemption is to become effective (the "Effective Date of Redemption") and the
Redemption Price. The Corporation shall not be entitled to send any Redemption
Notice and begin the redemption procedure unless it has (i) the full amount of
the Redemption Price, in cash, available in a demand or other immediately
available account in a bank or similar financial institution or (ii) immediately
available credit facilities, in the full amount of the Redemption Price, with a
bank or similar financial institution on the date the Redemption Notice is
delivered to the applicable holder. Notwithstanding the foregoing, the ninety
(90) day notice period referred to herein shall be extended with respect to any
holder of Series D Preferred Stock by such number of days after the date of the
Redemption Notice as such

                                       59
<PAGE>
 
holder is not permitted to sell all of its Series D Preferred Stock pursuant to
an effective registration statement filed with the Securities and Exchange
Commission under the Securities Act of 1933, as amended (or a successor statute)
(the "1933 Act") or pursuant to Rule 144(k) under the 1933 Act.

          The Redemption Price shall be paid to the holder of the Series D
Preferred Stock being redeemed within 10 business days of the Effective Date of
Redemption; provided, however, that the Corporation shall not be obligated to
deliver any portion of the Redemption Price until either the certificates
evidencing the Series D Preferred Stock being redeemed are delivered to the
office of the Corporation or the Transfer Agent, or the holder notifies the
Corporation or the Transfer Agent that such certificates have been lost, stolen
or destroyed and delivers the documentation in accordance with Section D.4(d)
hereof. Notwithstanding anything herein to the contrary, in the event that the
certificates evidencing the Series D Preferred Stock redeemed are not delivered
to the Corporation or the Transfer Agent prior to the 10th business day
following the Effective Date of Redemption, the redemption of the Series D
Preferred Stock pursuant to this Section D.3 shall still be deemed effective as
of the Effective Date of Redemption and the Redemption Price shall be paid to
the holder of Series D Preferred Stock redeemed within 5 business days of the
date the certificates evidencing the Series D Preferred Stock redeemed are
actually delivered to the Corporation or the Transfer Agent.

                  (g) If of any of the following events (each, a "Mandatory
Redemption Event") shall occur:

                      (i) Conversion and the Shares. The Corporation fails to
                          -------------------------    
issue shares of Common Stock (subject to the limitations set forth in Section
D.4(g)) to the holders of Series D Preferred Stock upon exercise by the holders
of their conversion rights in accordance with the terms of this Certificate of
Designation (for a period of at least sixty (60) days if such failure is solely
as a result of the circumstances governed by Section D.4(e) below and the
Corporation is using all commercially reasonable efforts to authorize a
sufficient number of shares of Common Stock as soon as practicable), fails to
transfer any certificate for shares of Common Stock issued to the holders upon
conversion of the Series D Preferred Stock and when required by Section D of the
Second Restated Certificate of Incorporation or the Registration Rights
Agreement, dated as of May 15, 1996, by and among the Corporation and the other
signatories thereto (the "Registration Rights Agreement") (or shares of Common
Stock issuable upon exercise of the warrants (the "Warrants") issued pursuant to
the Securities Purchase Agreement, dated as of May 15, 1996, by and between the
Corporation and the other signatory thereto (the "Purchase Agreement") in
accordance with the Warrants), or fails to remove any restrictive legend on any
certificate or any shares of Common Stock issued to the holders of Series D
Preferred Stock upon conversion of the Series D Preferred Stock as and when
required by this Second Restated Certificate of Incorporation, the Purchase
Agreement or the Registration Rights Agreement (or shares of Common Stock
issuable upon exercise of the Warrants in accordance with the Warrants) and any
such failure shall continue uncured for twenty (20) business days after the
Corporation shall have been notified thereof in writing by the holder;

                                       60
<PAGE>
 
                      (ii) Failure to Register. The Corporation fails to obtain
                           -------------------
effectiveness with the Securities and Exchange Commission (the "SEC") of the
Registration Statement (as defined in the Registration Rights Agreement) prior
to November 15, 1996 (other than because of issues raised by the SEC arising
from the transactions contemplated by the Purchase Agreement or because of a
change in the policy, procedures, interpretations, positions, practice or rules
of the SEC made public after the date hereof so long as, in either case, the
Corporation is using all commercially reasonable efforts to achieve the
effectiveness of such Registration Statement) or lapses in effect (or sales
otherwise cannot be made thereunder) for more than thirty (30) consecutive days
or sixty (60) days in any twelve (12) month period after such Registration
Statement becomes effective;

                       (iii) Receiver or Trustee. The Corporation or any
                             -------------------  
subsidiary of the Corporation shall make an assignment for the benefit of
creditors, or apply for or consent to the appointment of a receiver or trustee
for it or for all or substantially all of its property or business; or such a
receiver or trustee shall otherwise be appointed;

                       (iv) Bankruptcy. Bankruptcy, insolvency, reorganization
                            ---------- 
or liquidation proceedings or other proceedings for relief under any bankruptcy
law or any law for the relief of debtors shall be instituted by or against the
Corporation or any subsidiary of the Corporation.

          Then, upon the occurrence and during the continuation of any Mandatory
Redemption Event specified in subparagraphs (i) or (ii), at the option of the
holders of at least 50% of the then outstanding shares of Series D Preferred
Stock by written notice (the "Mandatory Redemption Notice") to the Corporation
of such Mandatory Redemption Event, the Corporation shall, and upon the
occurrence of any Mandatory Redemption Event specified in subparagraphs (iii) or
(iv), purchase the holder's shares of Series D Preferred Stock for an amount per
share equal to 125% multiplied by the Redemption Price in effect at the time of
the redemption hereunder.

          Subject to the limitations contained in Section D.4(g), if the
Corporation fails to pay the Mandatory Redemption Amount for each share within
five (5) business days of written notice that such amount is due and payable,
then each holder of Series D Preferred Stock shall have the right at any time,
so long as the Mandatory Redemption Event continues to require the Corporation,
upon written notice, to immediately issue (in accordance with the terms of
Section D.4 below), in lieu of the Mandatory Redemption Amount, with respect to
each outstanding share of Series D Preferred Stock held by such holder, the
number of shares of Common Stock of the Corporation equal to the Mandatory
Redemption Amount divided by the Conversion Price then in effect.

                4.  Conversion at the Option of the Holder.
                    --------------------------------------

                    (a) Each holder of shares of Series D Preferred Stock may,
at its option at any time and from time to time (whether or not the Corporation
has sent an Optional Conversion Notice to the holders of Series D Preferred
Stock pursuant to Section D.3), upon surrender of the certificates therefor,
convert any or all of its shares of Series D Preferred Stock into Common Stock
as follows (an "Optional Conversion"). Each share of Series D Preferred

                                       61
<PAGE>
 
Stock shall be convertible into such number of fully paid and nonassessable
shares of Common Stock as is determined by dividing (x) the sum of (I) the
Stated Value thereof, plus (II) unless the Corporation has timely redeemed such
Premium in cash in accordance with Section D.3, an amount equal to eight percent
(8%) per annum of such Stated Value for the period beginning on the date of
issuance of such share and ending on the Conversion Date (the "Premium"), by (y)
the then effective Conversion Price (as defined below); provided, however, that
in no event shall holders of shares of Series D Preferred Stock be entitled to
convert any such shares in excess of that number of shares upon conversion of
which the sum of (x) the number of shares of Common Stock beneficially owned by
the holder and its affiliates (other than shares of Common Stock which may be
deemed beneficially owned through the ownership of the unconverted portion of
the shares of Series D Preferred Stock and the unexercised portion of the
Warrants) and (y) the number of shares of Common Stock issuable upon the
conversion of the shares of Series D Preferred Stock with respect to which the
determination of this proviso is being made would result in beneficial ownership
by the holder and its affiliates of more than 4.9% of the outstanding shares of
Common Stock. For purposes of the second proviso to the immediately preceding
sentence, beneficial ownership shall be determined in accordance with Section
13(d) of the Securities Exchange Act of 1934, as amended, and Regulation 13 D-G
thereunder, except as otherwise provided in clause (x) of such proviso.

                  (b) The "Conversion Price" shall be the lesser of (i) the
Applicable Percentage (as hereinafter defined) of the average of the closing bid
prices for the Common Stock on the NASDAQ National Market ("NASDAQ"), or on the
principal securities exchange or other securities market on which the Common
Stock is then being traded, for the five (5) consecutive Trading Days (as
defined below) ending one Trading Day prior to the date (the "Conversion Date")
the Conversion Notice is sent by a holder to the Corporation via facsimile (the
"Variable Conversion Price"), and (ii) the average of the closing bid prices for
the Common Stock on NASDAQ for the five (5) consecutive Trading Days ending on
the Closing Date under the Purchase Agreement (the "Closing Date") (the "Fixed
Conversion Price") (subject to equitable adjustments from time to time pursuant
to the antidilution provisions of Section D.4(c) below). Applicable Percentage
means (i) 100%, if the Conversion Date is within forty (40) days after the
Closing Date, and (ii) 90%, if the Conversion Date is within eighty (80) days,
but more than forty (40) days, after the Closing Date, and (iii) 75%, if the
Conversion Date is more than eighty (80) days after the Closing Date.

                  (c) The Conversion Price shall be subject to adjustment
from time to time as follows:

                      (i) Adjustment to Fixed Conversion Price Due to Stock
                          -------------------------------------------------  
Split, Stock Dividend, Etc. If at any time when the Series D Preferred Stock is
- --------------------------
issued and outstanding, the number of outstanding shares of Common Stock is
increased by a stock split, stock dividend, or other similar event, the Fixed
Conversion Price shall be proportionately reduced, or if the number of
outstanding shares of Common Stock is decreased by a reverse stock split,
combination or reclassification of shares, or other similar event, the Fixed
Conversion Price shall be proportionately increased. In such event the
Corporation shall notify the Transfer Agent of such change on or before the
effective date thereof.

                                       62
<PAGE>
 
                      (ii) Adjustment to Variable Conversion Price. If at any
                           ---------------------------------------
time when Series D Preferred Stock is issued and outstanding, the number of
outstanding shares of Common Stock is increased or decreased by a stock split,
stock dividend, combination, reclassification or other similar event, which
event shall have taken place during the reference period for determination of
the Conversion Price for any Optional Conversion or Mandatory Conversion of the
Series D Preferred Stock, then the Variable Conversion Price shall be calculated
giving appropriate effect to the stock split, stock dividend, combination,
reclassification or other similar event for all five (5) Trading Days
immediately preceding the Conversion Date.

                      (iii) Adjustment Due to Merger, Consolidation, Etc. If,
                            --------------------------------------------
at any time when Series D Preferred Stock is issued and outstanding and prior to
the conversion of all Series D Preferred Stock, there shall be (i) any
reclassification or change of the outstanding shares of Common Stock (other than
a change in par value, or from par value to no par value, or from no par value
to par value, or as a result of a subdivision or combination), (ii) any
consolidation or merger of the Corporation with any other corporation (other
than a merger in which the Corporation is the surviving or continuing
corporation and its capital stock is unchanged), (iii) any sale or transfer of
all or substantially all of the assets of the Corporation or (iv) any share
exchange pursuant to which all of the outstanding shares of Common Stock are
converted into other securities or property, then the holders of Series D
Preferred Stock shall, upon being given at least thirty (30) days prior written
notice of such transaction, thereafter have the right to purchase and receive
upon conversion of Series D Preferred Stock, upon the basis and upon the terms
and conditions specified herein and in lieu of the shares of Common Stock
immediately theretofore issuable upon conversion, such shares of stock and/or
securities or other property as may be issued or payable with respect to or in
exchange for the number of shares of Common Stock immediately theretofore
purchasable and receivable upon the conversion of Series D Preferred Stock held
by such holders had such merger, consolidation, exchange of shares,
recapitalization, reorganization or other similar event not taken place and in
any such case appropriate provisions shall be made with respect to the rights
and interests of the holders of the Series D Preferred Stock to the end that the
provisions hereof (including, without limitation, provisions for adjustment of
the Conversion Price and of the number of shares issuable upon conversion of the
Series D Preferred Stock) shall thereafter be applicable, as nearly as may be
practicable in relation to any shares of stock or securities thereafter
deliverable upon the conversion thereof. The Corporation shall not effect any
transaction described in this subsection (c) unless (i) each holder of Series D
Preferred Stock has received written notice of such transaction at least thirty
(30) days prior thereto and in no event later than ten (10) days prior to the
record date for the determination of shareholders entitled to vote with respect
thereto, and (ii) the provisions of this paragraph have been complied with. The
above provisions shall similarly apply to successive reclassifications,
consolidations, mergers, sales, transfers or share exchanges.

                      (iv) No Fractional Shares. If any adjustment under this
                           --------------------
Section D.4(c) would create a fractional share of Common Stock or a right to
acquire a fractional share of Common Stock, such fractional share shall be
disregarded and the number of shares of Common Stock issuable upon conversion
shall be the next higher number of shares.

                                       63
<PAGE>
 
                  (d) In order to convert Series D Preferred Stock into full
shares of Common Stock, a holder shall: (i) fax a copy of the fully executed
notice of conversion in the form attached hereto as Exhibit A ("Notice of
                                                    ---------
Conversion") to the Corporation at the office of the Corporation for the Series
D Preferred Stock that the holder elects to convert the same, which notice shall
specify the number of shares of Series D Preferred Stock to be converted, the
applicable Conversion Price and a calculation of the number of shares of Common
Stock issuable upon such conversion (together with a copy of the first page of
each certificate to be converted) prior to Midnight, New York City time (the
"Conversion Notice Deadline") on the date of conversion specified on the Notice
of Conversion; and (ii) surrender the original certificates representing the
Series D Preferred Stock being converted (the "Preferred Stock Certificates"),
duly endorsed, along with a copy of the Notice of Conversion as soon as
practicable thereafter to the office of the Corporation for the Series D
Preferred Stock; provided, however, that the Corporation shall not be obligated
to issue certificates evidencing the shares of Common Stock issuable upon such
conversion unless either the Preferred Stock Certificates are delivered to the
Corporation as provided above, or the holder notifies the Corporation that such
certificates have been lost, stolen or destroyed (subject to the requirements of
subparagraph (i) below). In the case of a dispute as to the calculation of the
Conversion Price, the Corporation shall promptly issue such number of shares of
Common Stock that are not disputed in accordance with subparagraph (ii) below.
The Corporation shall submit the disputed calculations to its outside accountant
via facsimile within three (3) business days of receipt of the Notice of
Conversion. The accountant shall audit the calculations and notify the
Corporation and the holder of the results no later than 48 hours from the time
it receives the disputed calculations. The accountant's calculation shall be
deemed conclusive absent manifest error.

                      (i) Lost or Stolen Certificates. Upon receipt by the
                          ---------------------------
Corporation of evidence of the loss, theft, destruction or mutilation of any
Preferred Stock Certificates representing shares of Series D Preferred Stock,
and (in the case of loss, theft or destruction) of indemnity or security
reasonably satisfactory to the Corporation, and upon surrender and cancellation
of the Preferred Stock Certificate(s), if mutilated, the Corporation shall
execute and deliver new Preferred Stock Certificate(s) of like tenor and date.
However, the Corporation shall not be obligated to reissue such lost or stolen
Preferred Stock Certificate(s) if the holder contemporaneously requests the
Corporation to convert such Series D Preferred Stock.

                      (ii) Delivery of Common Stock Upon Conversion. Upon the
                           ---------------------------------------- 
surrender of certificates as described above from a holder of Series D Preferred
Stock accompanied by a Notice of Conversion, the Corporation shall issue and,
within two (2) business days (the "Delivery Period") after such surrender (or,
in the case of lost, stolen or destroyed certificates, after provision of
agreement and indemnification pursuant to subparagraph (i) above), deliver to or
upon the order of the holder (i) that number of shares of Common Stock for the
portion of the shares of Series D Preferred Stock converted as shall be
determined in accordance herewith and (ii) a certificate representing the
balance of the shares of Series D Preferred Stock not converted, if any. In
addition to any other remedies available to the holder, including actual damages
and/or equitable relief, the Corporation shall pay to a holder $250 in cash for
the first day beyond such Delivery Period that the Corporation fails to deliver
Common Stock issuable upon surrender of shares of Series D Preferred Stock with
a Notice of Conversion
                                       64
<PAGE>
 
and $500 per day in cash for each day thereafter until such time as the earlier
of the date that the Corporation has delivered all such Common Stock and the
tenth day beyond such Delivery Period. Such cash amount shall be paid to such
holder by the fifth day of the month following the month in which it has
accrued. In the event the Corporation fails to deliver such Common Stock prior
to the expiration of the ten (10) business day period after the Delivery Period
for any reason (whether due to a requirement of law or a stock exchange or
otherwise), such holder shall be entitled to (in addition to any other remedies
available to the holder) Conversion Default Payments in accordance with Section
D.4(e) hereof beginning on the expiration of such ten (10) business day period.

                      (iii) No Fractional Shares. If any conversion of Series D
                            --------------------
Preferred Stock would result in a fractional share of Common Stock or the right
to acquire a fractional share of Common Stock, such fractional share shall be
disregarded and the number of shares of Common Stock issuable upon conversion of
the Series D Preferred Stock shall be the next higher number of shares.

                      (iv) Conversion Date. The "Conversion Date" shall be the
                           ---------------
date specified in the Notice of Conversion, provided (i) that the advance copy
of the Notice of Conversion is faxed to the Corporation before Midnight, New
York City time, on the Conversion Date, and (ii) that the original Preferred
Stock Certificate(s), duly endorsed, are surrendered along with a copy of the
Notice of Conversion as soon as practicable thereafter to the office of the
Corporation or the Transfer Agent for the Series D Preferred Stock. The person
or persons entitled to receive the shares of Common Stock issuable upon
conversion shall be treated for all purposes as the record holder or holders of
such securities as of the Conversion Date and all rights with respect to the
shares of Series D Preferred Stock surrendered shall forthwith terminate except
the right to receive the shares of Common Stock or other securities or property
issuable on such conversion.

                  (e) A number of shares of the authorized but unissued Common
Stock sufficient to provide for the conversion of the Series D Preferred Stock
outstanding at the then current Conversion Price shall at all times be reserved
by the Corporation, free from preemptive rights, for such conversion or
exercise. If the Corporation shall issue any securities or make any change in
its capital structure which would change the number of shares of Common Stock
into which each share of the Series D Preferred Stock shall be convertible at
the then current Conversion Price, the Corporation shall at the same time also
make proper provision so that thereafter there shall be a sufficient number of
shares of Common Stock authorized and reserved, free from preemptive rights, for
conversion of the outstanding Series D Preferred Stock on the new basis. If, at
any time a holder of shares of Series D Preferred Stock submits a Conversion
Notice, the Corporation does not have sufficient authorized but unissued shares
of Common Stock available to effect such conversion in accordance with the
provisions of this Section 4 (a "Conversion Default"), the Corporation shall
issue to the holder all of the shares of Common Stock which are available to
effect such conversion (including, with the Holder's written consent, any shares
underlying outstanding Warrants ("Borrowed Shares")). The number of shares of
Series D Preferred Stock included in the Notice of Conversion which exceeds the
amount which is then convertible into available shares of Common Stock
(including Borrowed
                                       65
<PAGE>
 
Shares, if any) (the "Excess Amount") shall, notwithstanding anything to the
contrary contained herein, not be convertible into Common Stock in accordance
with the terms hereof until (and at the holder's option at any time after) the
date additional shares of Common Stock are authorized by the Corporation to
permit such conversion, at which time the Conversion Price in respect thereof
shall be the lesser of (i) the Conversion Price on the Conversion Date Default
(as defined below) and (ii) the Conversion Price on the Conversion Date elected
by the holder in respect thereof. The Corporation shall pay to the holder
payments ("Conversion Default Payments") for a Conversion Default in the amount
of (N/365), multiplied by the sum of the Stated Value with respect to each share
of Series D Preferred Stock, multiplied by the Default Amount (as defined below)
on the first day of the Conversion Default (the "Conversion Default Date"),
multiplied by .25, where (i) N = the number of days from the Conversion Default
Date to the earlier of (A) the date (the "Authorization Date") that the
Corporation authorizes a sufficient number of shares of Common Stock to effect
conversion of the full number of shares of Series D Preferred Stock and (B) the
date such share of Series D Preferred Stock is redeemed in accordance with
Section D.4(d) and (ii) "Default Amount" means the Excess Amount plus the number
of shares of Series D Preferred Stock that would not be convertible as a result
of this Section D.4(e) but for the Borrowed Shares. The Corporation shall send
notice to the holder of the authorization of additional shares of Common Stock,
the Authorization Date and the amount of holder's accrued Conversion Default
Payments. The accrued Conversion Default Payments for each calendar month shall
be paid in cash or, subject to the limitations contained in Section D.4(g),
shall be convertible into Common Stock at the Conversion Price, at the holder's
option, as follows:

                      (i) In the event holder elects to take such payment in
cash, cash payment shall be made to holder by the fifth day of the month
following the month in which it has accrued; and

                      (ii) In the event holder elects to take such payment in
Common Stock, the holder may convert such payment amount into Common Stock at
the Conversion Price (as in effect at the time of Conversion) at any time after
the fifth day of the month following the month in which it has accrued in
accordance with the terms of this Section 4.

                       1. Nothing herein shall limit the holder's right to
         pursue actual damages for the Corporation's failure to maintain a
         sufficient number of authorized shares of Common Stock, and each holder
         shall have the right to pursue all remedies available at law or in
         equity (including a decree of specific performance and/or injunctive
         relief).

                  (f) Upon the occurrence of each adjustment or readjustment of
the Conversion Price pursuant to this Section 4, the Corporation, at its
expense, shall promptly compute such adjustment or readjustment in accordance
with the terms hereof and prepare and furnish to each holder of Series D
Preferred Stock a certificate setting forth such adjustment or readjustment and
showing in detail the facts upon which such adjustment or readjustment is based.
The Corporation shall, upon the written request at any time of any holder of
Series D Preferred Stock, furnish or cause to be furnished to such holder a like
certificate setting forth (i) such adjustment or readjustment, (ii) the
Conversion Price at the time in effect and (iii) the

                                       66
<PAGE>
 
number of shares of Common Stock and the amount, if any, of other securities or
property which at the time would be received upon conversion of a share of
Series D Preferred Stock.

                       (g) Notwithstanding anything contained herein to the
contrary, in no event shall the aggregate number of shares of Common Stock
issuable upon conversion or redemption of, or otherwise issuable with respect
to, all of the Series D Preferred Stock issued by the Corporation pursuant to
the Purchase Agreement (including, without limitation, all shares of Common
Stock issued with respect to such Series D Preferred Stock pursuant to Section
D.3 and Section D.4(e) hereof, but without taking into account any shares of
Common Stock issuable upon exercise of Warrants) plus all shares of Common Stock
issuable pursuant to Section 2(c) of the Registration Rights Agreement exceed
2,424,884 (subject to equitable adjustments from time to time pursuant to the
antidilution provisions of Section D.4(c) above). In the event the Corporation
is prohibited from issuing shares of Common Stock as a result of the operation
of this Section D.4(g), the provisions of Section 3, subparagraph (ii) of
Section D.4(d) and Section D.4(e) shall apply to the extent applicable.

               5.    Mandatory Conversion.
                     --------------------
          
          Each share of Series D Preferred Stock issued and outstanding on May
15, 2001, automatically shall be converted into shares of Common Stock on such
date at the then effective Conversion Price in accordance with the provisions of
Section D.4 hereof (the "Mandatory Conversion").

               6.    Voting Rights.
                     -------------

          The holders of the Series D Preferred Stock have no voting power
whatsoever, except as otherwise provided by the Delaware General Corporation Law
("DGCL"), and in this Section D.6, and in Section D.7 below.

         Notwithstanding the above, the Corporation shall provide each holder of
Series D Preferred Stock with prior notification of any meeting of the
shareholders (and copies of proxy materials and other information sent to
shareholders). In the event of any taking by the Corporation of a record of its
shareholders for the purpose of determining shareholders who are entitled to
receive payment of any dividend or other distribution, any right to subscribe
for, purchase or otherwise acquire (including by way of merger, consolidation or
recapitalization) any share of any class or any other securities or property, or
to receive any other right, or for the purpose of determining shareholders who
are entitled to vote in connection with any proposed sale, lease or conveyance
of all or substantially all of the assets of the Corporation, or any proposed
liquidation, dissolution or winding up of the Corporation, the Corporation shall
mail a notice to each holder, at least ten (10) days prior to the record date
specified therein (or 30 days prior to the consummation of the transaction or
event, whichever is earlier), of the date on which any such record is to be
taken for the purpose of such dividend, distribution, right or other event, and
a brief statement regarding the amount and character of such dividend,
distribution, right or other event to the extent known at such time.

                                       67
<PAGE>
 
          To the extent that under the DGCL the vote of the holders of the
Series D Preferred Stock, voting separately as a class or series as applicable,
is required to authorize a given action of the Corporation, the affirmative vote
or consent of the holders of at least a majority of the shares of the Series D
Preferred Stock represented at a duly held meeting at which a quorum is present
or by written consent of a majority of the shares of Series D Preferred Stock
(except as otherwise may be required under the DGCL) shall constitute the
approval of such action by the class. To the extent that under the DGCL holders
of the Series D Preferred Stock are entitled to vote on a matter with holders of
Common Stock, voting together as one class, each share of Series D Preferred
Stock shall be entitled to a number of votes equal to the number of shares of
Common Stock into which it is then convertible using the record date for the
taking of such vote of shareholders as the date as of which the Conversion Price
is calculated. Holders of the Series D Preferred Stock shall be entitled to
notice of (and copies of proxy materials and other information sent to
shareholders) all shareholder meetings or written consents with respect to which
they would be entitled to vote, which notice would be provided pursuant to the
Corporation's by-laws and the DGCL.

               7. Protection Provision.
                  --------------------
         
          So long as shares of Series D Preferred Stock are outstanding, the
Corporation shall not, without first obtaining the approval (by vote or written
consent, as provided by the DGCL) of the holders of at least a majority of the
then outstanding shares of Series D Preferred Stock:

                  (a) alter or change the rights, preferences or privileges of
the Series D Preferred Stock or any other class or series of capital stock of
the Corporation so as to affect adversely the Series D Preferred Stock;

                  (b) create any new class or series of capital stock having a
preference over the Series D Preferred Stock as to distribution of assets upon
liquidation, dissolution or winding up of the Corporation ("Senior Securities");

                  (c) create any new class or series of capital stock ranking
pari passu with the Series D Preferred Stock as to distribution of assets upon
liquidation, dissolution or winding up of the Corporation (as previously defined
in Section D.1 hereof, "Pari Passu Securities");

                  (d) increase the authorized number of shares of Series D
Preferred Stock.

                  (e) do any act or thing not authorized or contemplated by this
Certificate of Designation which would result in taxation of the holders of
shares of the Series D Preferred Stock under Section 305 of the Internal Revenue
Code of 1986, as amended (or any comparable provision of the Internal Revenue
Code as hereafter from time to time amended); or

                  (f) issue after the Closing Date any Senior Securities or Pari
Passu Securities (other than Common Stock).

                                       68
<PAGE>
 
          In the event holders of at least a majority of the then outstanding
shares of Series D Preferred Stock agree to allow the Corporation to alter or
change the rights, preferences or privileges of the shares of Series D Preferred
Stock, pursuant to subsection (a) above, so as to affect the Series D Preferred
Stock, then the Corporation will deliver notice of such approved change to the
holders of the Series D Preferred Stock that did not agree to such alteration or
change (the "Dissenting Holders") and Dissenting Holders shall have the right
for a period of twenty (20) days to convert pursuant to the terms of this
Section D of the Second Restated Certificate of Incorporation of the Corporation
as they exist prior to such alteration or change or continue to hold their
shares of Series D Preferred Stock.
 
               8. Notices.
                  -------

          Each holders of Series D Preferred Stock shall send a copy of all
notices to be given to the Corporation under this Section D of the Second
Restated Certificate of Incorporation to such one (1) counsel as the Corporation
may designate in writing at least five (5) business days prior to such holder
sending such notice. For purposes of this Section D.8, the initial counsel
designated by the Corporation for receiving copies of notices under this Section
D of the Second Restated Certificate of Incorporation shall be Jackson Tufts
Cole & Black, LLP, 60 South Market Street, San Jose, California 95113,
Attention: Richard Scudellari, Telecopier (408) 998-4889.

          FIFTH: In furtherance and not in limitation of the powers conferred by
statute, the Board of Directors is expressly authorized to adopt, alter or
repeal the by-laws of the Company, subject always to the right of the
stockholders entitled to vote with respect thereto to adopt additional by-laws
and to alter or repeal by-laws adopted by the Board of Directors, and to provide
in connection therewith that any by-law adopted or altered by the stockholders
may be altered or repealed only by a vote of a designated proportion of the
stockholders.

          SIXTH:

               (A) If with respect to any of the following transactions, a
stockholder vote is required by law or by any other rules or policies to which
the Company may then be subject, the affirmative vote of two-thirds of the
outstanding stock entitled to vote thereon, given in person or by proxy, at a
meeting called for the purpose shall be necessary.

                   (a) To approve (i) the lease, sale, exchange, transfer or
         other disposition by the Company of all or substantially all, of its
         assets or business to a related company, or an affiliate of a related
         company, or (ii) the consolidation of the Company with or its merger
         into a related company or an affiliate of a related company, or (iii)
         the merger into the Company or a subsidiary of the Company of a related
         company or an affiliate of a related company, or (iv) an acquisition of
         substantially all of the assets of a corporation or of the securities
         representing such assets, in which the Company, or any subsidiary of
         the Company, is the acquiring corporation and voting shares of the
         Company are issued or transferred to a related company or an affiliate
         of a related company, or to stockholders of a related company, or an
         affiliate of a related company, or an associated person.

                                       69
<PAGE>
 
                       (b) To approve any agreement, contract, or other
         arrangement with a related company or an affiliate of a related
         company, or an associated person providing for any of the transactions
         described in subparagraph (a) above; or

                       (c) To effect any amendment of the Certificate of
         Incorporation which changes the provisions of this Article Sixth:

                           1. For the purpose of this Article Sixth, (i) a
         "related company" in respect of a given transaction, shall be any
         person, partnership, corporation, or firm (except a subsidiary of the
         Company at least a majority of whose stock is owned by the Company)
         which, together with its affiliates and associated persons owns of
         record or beneficially, directly or indirectly, in excess of 10% of the
         outstanding shares of the Company, entitled to vote upon such
         transaction, as of the record date used to determine the stockholders
         of the Company entitled to vote upon such transaction; (ii) an
         "affiliate" of a related company shall be any individual, joint
         venture, trust, partnership, or corporation which, directly or
         indirectly, through one or more intermediaries, controls, or is
         controlled by, or is under common control with, the related company;
         and (iii) an "associated person" of a related company shall be any
         officer or director or any beneficial owner, directly or indirectly, of
         10% or more of any class of equity security of such related company or
         any of its affiliates.

         The determination of the Board of Directors of the Company, based on
information known to the Board of Directors and made in good faith, shall be
conclusive as to whether any person, partnership, corporation or firm is a
related company or affiliate or associated person as defined in this Article
Sixth.

          (B) If the provisions of this Article Sixth are applicable to a
transaction and if the provisions of Section 262 of the Delaware General
Corporation Law, or any similar provision hereinafter enacted, would be
applicable thereto but for the provisions of subparagraph (k) thereof, then the
stockholders of the Company shall be entitled to the rights granted by Section
262 of the Delaware General Corporation Law or any similar provision hereafter
enacted notwithstanding the exemptions contained in subparagraph (k) of such
section.

          (C) If the provisions of this Article Sixth are applicable to a
transaction, but the provisions of Section 262 of the Delaware General
Corporation Law are not applicable thereto, notwithstanding the elimination of
the exemptions contained in subparagraph (k) of such Section, then a holder of
dissenting shares with respect to such transaction shall be entitled to receive
from the Company, payment for the value of his stock on the effective date of
the transaction, excluding any appreciation or depreciation in value from the
expectation or accomplishment of the transaction.

                       (a) To qualify as a holder of dissenting shares, a
         stockholder shall, before the taking of the vote on the transaction,
         file with the Company a written objection to such proposed transaction.
         Following the effective date of such transaction, the Company shall
         notify each stockholder who has filed such written objection and whose
         shares were not voted in favor of the transaction, that the transaction
         has become
                                       70
<PAGE>
 
         effective. The notice shall be sent by registered or certified mail,
         return receipt requested, addressed to the stockholder at his address
         as it appears on the records of the Company. Such stockholder shall,
         within 20 days after the mailing of the notice, demand, in writing,
         from the Company, payment of the value of his stock. The demand shall
         state the number and class of shares held of record by the stockholder
         which he demands that the Company purchase and shall contain a request
         that the Company state what it claims to be the fair market value of
         these shares. In addition, within 20 days after the date of mailing of
         such notice, such stockholder shall submit to the Company at its
         principal office or at the office of any transfer agent thereof, his
         certificate representing the shares which he demands that the Company
         purchase to be stamped or endorsed with a statement that the shares are
         dissenting shares or to be exchanged for a certificate of appropriate
         denomination to be so stamped or endorsed. Upon subsequent transfers of
         such dissenting shares on the books of the Company, the new
         certificates issued therefor shall bear a like statement, together with
         the name of the original dissenting holder of the shares.

                 (b) As used in this paragraph (C) "dissenting shares" means
         shares which come within all the following descriptions:

                     1. Which were held of record on the date for the
         determination of stockholders entitled to vote at the meeting at which
         the transaction was approved and the holder thereof filed written
         objection thereto with the Company before the taking of the vote
         thereon and did not vote in favor thereof.

                     2. Which the holder has demanded that the Company purchase
         at their fair market value in accordance with subparagraph (a) above.

                     3. Which the holder has submitted for endorsement in
         accordance with subparagraph (a) above.

                  (c) Within five days after receipt of a copy of a demand for
         purchase of shares as dissenting shares, the Company shall, by
         registered or certified mail, return receipt requested, addressed to
         the stockholder at his address as it appears on the records of the
         Company, mail a written offer to purchase the shares if they are
         determined to be dissenting shares, at a price deemed by the Company to
         represent their fair market value.

                  (d) Payment of the fair market value of the dissenting shares
         shall be made within 30 days after the amount thereof has been agreed
         upon, upon surrender of the certificates therefor unless provided
         otherwise by agreement.

                  (e) If the Company shall deny that the shares are dissenting
         shares, or the Company shall fail to make an offer for the shares, or
         the Company and the stockholder fail to agree upon the fair market
         value of the shares, the Company or any stockholder demanding purchase
         of his shares as dissenting shares, within four months after the date
         upon which the Company mailed notice that the transaction was
         effective, but not thereafter, may make written demand to the American
         Arbitration Association,

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<PAGE>
 
         Los Angeles, California, for a determination of the value of the
         dissenting shares or of whether the shares are dissenting shares, or
         both, in accordance with the Commercial Arbitration Rules of such
         Association, which arbitration shall be conducted in Los Angeles,
         California. If such arbitration is commenced by the Company, there
         shall be named therein all stockholders who have theretofore qualified
         as dissenting stockholders. If such arbitration is commenced by any one
         or more of such stockholders, the Company shall be permitted to join
         therein all stockholders who have theretofore qualified as dissenting
         stockholders. The arbitration shall be conducted before a panel of
         three arbitrators selected in accordance with the Commercial
         Arbitration Rules of the America Arbitration Association, and such
         panel of arbitrators shall determine those stockholders who have
         complied with the provisions of this Paragraph (C), and who have become
         entitled to the valuation of any payment for their shares and the value
         of such dissenting shares. Each stockholder who is a party to such
         arbitration, and the Company, shall be afforded reasonable opportunity
         to submit pertinent evidence on the value of the shares. Upon the
         determination of the value of the stock and of the stockholders
         entitled to payment therefor by the panel of arbitrators, such panel of
         arbitrators shall direct the payment of such value to the stockholders
         entitled thereto by the Company upon transfer to it of the certificates
         representing such stock, which determination may be enforced by a court
         of competent jurisdiction in the State of New York.

                     (f) The costs of the arbitration shall be assessed or
         apportioned as the panel of arbitrators considers equitable.

                     (g) All action required or permitted to be taken by the
         panel of arbitrators shall be taken by the majority decision of the
         members of the panel of arbitrators.

                     (h) Except as expressly limited in this Paragraph (C),
         holders of dissenting shares continue to have all the rights and
         privileges incident to those shares until the fair market value of
         their shares is agreed upon or determined. A holder of dissenting
         shares may not withdraw his dissent or demand for payment unless the
         Company, by its Board of Directors, consents thereto.

                     (i) Dissenting shares lose their status as dissenting
         shares, and the holders thereof cease to be entitled to require the
         Company to purchase their shares upon the happening of any of the
         following

                         1. The Company abandons the transaction which the
         dissenting stockholder did not approve.

                         2. The shares are surrendered for conversion into
         shares of another class in accordance with the Certificate of
         Incorporation, or transferred prior to their submission for endorsement
         in accordance with subparagraph (a) above.

                         3. The holder of the dissenting shares and the Company
         do not agree upon the status of the shares as dissenting shares and
         upon the purchase price of the

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<PAGE>
 
         shares, and the holder of the dissenting shares does not file a written
         demand for arbitration or intervene in an arbitration or is not made a
         party to an arbitration in respect to dissenting shares within four
         months after the date on which the notice of the effective date of the
         transaction is mailed to the stockholders.

                     (j) If litigation is instituted to test the sufficiency or
         regularity of the votes of the stockholders in authorizing a
         transaction, the proceeding for compensation of any holder of
         dissenting shares shall be suspended until final determination of such
         litigation.

         SEVENTH: The Company shall indemnify any and all persons whom it has
the power to indemnify pursuant to the General Corporation Law of Delaware
against any and all expenses, judgments, fines, amounts paid in settlement, and
any other liabilities to the fullest extent permitted by such law and may at the
discretion of the Board of Directors, purchase and maintain insurance, at its
expense, to protect itself and such persons against any expense, judgment, fine,
amount paid in settlement or other liability, whether or not the Company would
have the power to so indemnify such person under the General Corporation Law of
Delaware.

         EIGHTH: A director of the Company shall not be personally liable to the
Company or its stockholders for monetary damages for breach of fiduciary duty as
a director, except for liability (i) for any breach of the director's duty of
loyalty to the Company or its stockholders, (ii) for acts or omissions not in
good faith or which involve intentional misconduct or a knowing violation of
law, (iii) under Section 174 of the Delaware General Corporation Law or (iv) for
any transaction from which the director derived an improper personal benefit. If
the Delaware General Corporation Law is amended to authorize corporate action
further eliminating or limiting the personal liability of directors, then the
liability of a director of the Company shall be eliminated or limited to the
fullest extent permitted by the Delaware General Corporation Law, as so amended.
Any repeal or modification of this Article by the stockholders of the Company
shall not adversely affect any right or protection of a director of the Company
existing at the time of such repeal or modification.

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<PAGE>
 
          IN WITNESS WHEREOF, OXIS INTERNATIONAL ,INC., a Delaware corporation
has caused this Second Restated Certificate of Incorporation to be signed by its
Chairman of the Board and attested by its Secretary, this _____ day of August,
1996.



                                                OXIS INTERNATIONAL, INC., a 
                                                Delaware corporation



                                                -------------------------------
                                                Ray R. Rogers,
                                                Chairman of the Board



ATTEST:


By:   _______________________
      Jon S. Pitcher,
      Secretary


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                                    EXHIBIT A


                              NOTICE OF CONVERSION

                    (To be executed by the Registered Holder
                in order to Convert the Series D Preferred Stock)


         The undersigned hereby irrevocably elects to convert shares of Series D
Preferred Stock, represented by stock certificate No.(s). (the "Preferred Stock
Certificates") into shares of common stock ("Common Stock") of OXIS
International, Inc. (the "Corporation") according to the conditions of the
Corporation's Certificate of Incorporation with respect to Series D Preferred
Stock, as of the date written below. If securities are to be issued in the name
of a person other than the undersigned, the undersigned will pay all transfer
taxes payable with respect thereto and is delivering herewith such certificates.
No fee will be charged to the Holder for any conversion, except for transfer
taxes, if any. A copy of each Preferred Stock Certificate is attached hereto (or
evidence of loss, theft or destruction thereof).

         The undersigned represents and warrants that all offers and sales by
the undersigned of the securities issuable to the undersigned upon conversion of
Series D Preferred Stock shall be made pursuant to registration of the
securities under the Securities Act of 1933, as amended (the "Act"), or pursuant
to an exemption from registration under the Act.

                           Date of Conversion:_______________________________

                           Applicable Conversion Price:______________________

                           Number of Shares of
                           Common Stock to be Issued:________________________


                           Signature:________________________________________
    
                           Name:_____________________________________________

                           Address:__________________________________________




* The Corporation is not required to issue shares of Common Stock until the
original Series D Preferred Stock Certificate(s) (or evidence of loss, theft or
desctruction thereof) to be converted are received by the Corporation or its
Transfer Agent. the Corporation shall issue and deliver 

                                       75
<PAGE>
    
shares of Common Stock to an overnight courier not later than two (2) business
days following receipt of the original Preferred Stock Certificate(s) to be
converted, and shall make payments pursuant to the Certificate of Incorporation
for the number of business days such issuance and delivery is late.

                                       76

<PAGE>
 
                                 EXHIBIT 10 (E)

                        SILICON VALLEY FINANCIAL SERVICES
                        A Division of Silicon Valley Bank
                                3003 Tasman Drive
                             Santa Clara, Ca. 95054
                        (408)654-1000 - Fax (408)980-6410

                               FACTORING AGREEMENT

         This Factoring Agreement (the "Agreement) is made on the SIXTH day of
SEPTEMBER, 1996, by and between Silicon Valley Financial Services (a division of
Silicon Valley Bank) ("Buyer") having a place of business at the address
specified above and OXIS INTERNATIONAL, INC., A DELAWARE corporation, (the
"Parent"), and its wholly owned subsidiary, OXIS ACQUISITION CORPORATION (the
"Subsidiary"). The Parent and the Subsidiary are jointly referred to herein as
the "Seller" having its principal place of business and chief executive office
at
                    Street Address:     6040 N. Cutter Circle, Suite 317
                              City:     Portland
                            County:     Multnomah
                             State:     Oregon
                          Zip code:     97271
                               Fax:     94-1620407
1.  DEFINITIONS. When used herein, the following terms shall have the following 
     meanings.
     1.1.     "Account Balance" shall mean, on any given day, the gross amount 
              of all Purchased Receivables unpaid on that day.
     1.2.     "Account Debtor" shall have the meaning set forth in the
              California Uniform Commercial Code and shall include any person
              liable on any Purchased Receivable, including without limitation,
              any guarantor of the Purchased Receivable and any issuer of a
              letter of credit or banker's acceptance.
     1.3.     "Adjustments" shall mean all discounts, allowances, returns,
              disputes, counterclaims, offsets, defense, rights of recoupment,
              rights of return, warranty claims, or short payments, asserted by
              or on behalf of any Account Debtor with respect to any Purchased
              Receivable.
     1.4.     "Administrative Fee" shall have the meaning as set forth in 
              Section 3.3 hereof.
     1.5.     "Advance" shall have the meaning set forth in Section 2.2 hereof.
     1.6.     "Collateral" shall have the meaning set forth in Section 8 hereof.
     1.7.     "Collections" shall mean all good funds received by Buyer from or 
              on the behalf of an Account Debtor with respect to Purchased 
              Receivables.
     1.8.     "Compliance Certificate" shall mean a certificate, in a form
              provided by Buyer to Seller, which contains the certification of
              the chief financial officer of Seller that, among other things,
              the representations and warranties set forth in this Agreement are
              true and correct as of the date such certificate is delivered.

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<PAGE>
 
     1.9.     "Event of Default" shall have the meaning set forth in Section 9 
              hereof.
     1.10.    "Finance Charges" shall have the meaning set forth in Section 3.2 
              hereof.
     1.11.    "Invoice Transmittal" shall mean a writing signed by an authorized
              representative of Seller which accurately identifies the
              receivables which Buyer, at its election, may purchase, and
              includes for each such receivable the correct amount owed by the
              Account Debtor, the name and address of the Account Debtor, the
              invoice number, the invoice date and the account code.
     1.12.    "Obligations" shall mean all advances, financial accommodations,
              liabilities, obligations, covenants and duties owing, arising, due
              or payable by Seller to Buyer of any kind or nature, present or
              future, arising under or in connection with this Agreement or
              under any other document, instrument or agreement, whether or not
              evidenced by any note, guarantee or other instrument, whether
              arising on account or by overdraft, whether direct or indirect
              (including those acquired by assignment) absolute or contingent,
              primary or secondary, due or to become due, now owing or hereafter
              arising, and however acquired; including, without limitation, all
              Advances, Finance Charges, Administrative Fees, interest,
              Repurchase Amounts, fees, expenses, professional fees and
              attorneys' fees and other sums chargeable to Seller hereunder or
              otherwise.
     1.13.    "Purchased Receivable" shall mean all those accounts, receivables,
              chattel paper, instruments, contract rights, documents, general
              intangibles, letters of credit, drafts, bankers acceptances, and
              rights to payment, and all proceeds thereof (all of the foregoing
              being referred to as "receivables") arising out of the invoices
              and other agreements identified on or delivered with any Invoice
              Transmittal delivered by Seller to Buyer which Buyer elects to
              purchase and for which Buyer makes an Advance.
     1.14.    "Refund" shall have the meaning set forth in Section 3.5 hereof.
     1.15.    "Reserve" shall have the meaning set forth in Sections 2.4 hereof.
     1.16.    "Repurchase Amount" shall have the meaning set forth in Section 
              4.2 hereof.
     1.17.    "Reconciliation Date" shall mean the last calendar day of each 
              Reconciliation Period.
     1.18.    "Reconciliation Period" shall mean each calendar month of the
              year.

2. PURCHASE AND SALE OF RECEIVABLE.
     2.1.     OFFER TO SELL RECEIVABLES. During the term hereof, and provided
              that there does not then exist any Event of Default or any event
              that with notice, lapse of time or otherwise would constitute an
              Event of Default, Seller may request that Buyer purchase
              receivables and Buyer may, in its sole discretion, elect to
              purchase receivables. Seller shall deliver to Buyer an Invoice
              Transmittal with respect to any receivable for which a request for
              purchase is made. An authorized representative of Seller shall
              sign each Invoice Transmittal delivered to Buyer. Buyer shall be
              entitled to rely on all the information provided by Seller to
              Buyer on or with the Invoice Transmittal and to rely on the
              signature on any Invoice Transmittal as an authorized signature of
              Seller.

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<PAGE>
 
     2.2.     ACCEPTANCE OF RECEIVABLES. Buyer shall have no obligation to
              purchase any receivable listed on an Invoice Transmittal. Buyer
              may exercise its sole discretion in approving the credit of each
              Account Debtor before buying any receivable. Upon acceptance by
              Buyer of all or any of the receivables described on any Invoice
              Transmittal, Buyer shall pay to Seller 80 (%) percent of the face
              amount of each receivable Buyer desires------to purchase. Such
              payment shall be the "Advance" with respect to such receivable.
              Buyer may, from time to time, in its sole discretion, change the
              percentage of the Advance. Upon Buyer's acceptance of the
              receivable and payment to Seller of the Advance, the receivable
              shall become a "Purchased Receivable." It shall be a condition to
              each advance that (i) all of the representations and warranties
              set forth in Section 6 of this Agreement be true and correct on
              and as of the date of the related Invoice Transmittal and on and
              as of the date of such Advance as though made at and as of each
              such date, and (ii) no Event of Default or any event or condition
              that with notice, lapse of time or otherwise would constitute an
              Event of Default shall have occurred and be continuing, or would
              result from such Advance. Notwithstanding the foregoing, in no
              event shall the aggregate amount of all Purchased Receivables
              outstanding at any time exceed FIVE HUNDRED THOUSAND AND
              NO/100**** Dollars ($500,000.00).
     2.3.     EFFECTIVENESS OF SALE TO BUYER. Effective upon Buyers' payment of
              an Advance, and for and in consideration thereof and in
              consideration of the covenants of this Agreement, Seller hereby
              absolutely sells, transfers and assigns to Buyer, all of Seller's
              right, title and interest in and to each Purchased Receivable and
              all monies due or which may become due on or with respect to such
              Purchased Receivable. Buyer shall be the absolute owner of each
              Purchased Receivable. Buyer shall have, with respect to any goods
              related to the Purchased Receivable, all the rights and remedies
              of an unpaid seller under the California Uniform Commercial Code
              and other applicable law, including the rights of replevin, claim
              and delivery, reclamation and stoppage in transit.
     2.4.     ESTABLISHMENT OF A RESERVE. Upon the purchase by Buyer of each
              Purchased Receivable, Buyer shall establish a reserve. The reserve
              shall be the amount by which the face amount of the Purchased
              Receivable exceeds the advance on that Purchased Receivable (the
              "Reserve"); provided, the Reserve with respect to all Purchased
              Receivables outstanding at any one time shall be an amount not
              less than 20(%) percent of the Account Balance at that time and
              may be set at a higher percentage at Buyer's sole discretion. The
              reserve shall be a book balance maintained on the records of Buyer
              and shall not be a segregated fund.

3. COLLECTIONS, CHARGES AND REMITTANCES.
     3.1.     COLLECTIONS. Upon receipt by Buyer of Collections, Buyer shall
              promptly credit such Collections to Seller's Account Balance on a
              daily basis; provided, that if Seller is in default under this
              Agreement, Buyer shall apply all Collections to Seller's
              Obligations hereunder in such order and manner as Buyer may
              determine. If an item 

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<PAGE>
 
              of collection is not honored or Buyer does not receive good funds
              for any reason, the amount shall be included in the Account
              Balance as if the Collections had not been received and Finance
              Charges under Section 3.2 shall accrue thereon.
     3.2.     FINANCE CHARGES. On each Reconciliation Date Seller shall pay to
              Buyer a finance charge in an amount equal to 2.0(%) percent per
              month of the average daily Account Balance outstanding during the
              applicable Reconciliation Period (the "Finance Charges"). Buyer
              shall deduct the accrued Finance Charges from the Reserve as set
              forth in Section 3.5 below.
     3.3.     ADMINISTRATIVE FEE. On each Reconciliation Date Seller shall pay
              to Buyer an Administrative Fee equal to 1.0 (%) percent of the
              face amount of each Purchased Receivable first purchased during
              that Reconciliation Period (the "Administrative Fee"). Buyer shall
              deduct the Administrative Fee from the Reserve as set forth in
              Section 3.5 below.
     3.4.     ACCOUNTING. Buyer shall prepare and send to Seller after the close
              of business for each Reconciliation Period, an accounting of the
              transactions for that Reconciliation Period, including the amount
              of all Purchased Receivables, all Collections, and Adjustments,
              Finance Charges, and the Administrative Fee. The accounting shall
              be deemed correct and conclusive unless Seller makes written
              objection to Buyer within thrity (30) days after the Buyer mails
              the accounting to Seller.
     3.5.     REFUND TO SELLER. Provided that there does not exist an Event of
              Default or any condition that with notice, lapse of time or
              otherwise would constitute an Event of Default, Buyer shall refund
              to Seller by check after the Reconciliation Date, the amount, if
              any, which Buyer owes to Seller at the end of the Reconciliation
              Period according to the accounting prepared by Buyer for the
              Reconciliation Period (the "Refund"). The Refund shall be an
              amount equal to:
              (A) (1) The Reserve as of the beginning of that Reconciliation
                  Period, PLUS
                  (2) the Reserve created for each Purchased Receivable
                  purchased during that Reconciliation Period, MINUS 
              (B) The total for that Reconciliations Period of:
                  (1) the Administrative Fee;
                  (2) Finance Charges;
                  (3) Adjustments;
                  (4) Repurchase Amounts, to the extent Buyer has agreed to 
                  accept payment thereof by deduction from the Refund;
                  (5) the Reserve for the Account Balance as of the first day of
                  the following Reconciliation Period in the minimum percentage
                  set forth in Section 2.4 hereof; and 
                  (6) all amounts due, including professional fees and expenses,
                  as set forth Section 12 for which oral or written demand has
                  been made by Buyer to Seller during that Reconciliation Period
                  to the extent Buyer has agreed to accept payment thereof by
                  deduction from the Refund.

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<PAGE>
 
     In the event the formula set forth in this Section 3.5 results in an amount
     due to Buyer from Seller, Seller shall make such payment in the same manner
     as set forth in Section 4.3 hereof for repurchases. If the formula set
     forth in this Section 3.5 results in an amount due to Seller from Buyer,
     Buyer shall make such payment by check, subject to Buyer's rights under
     Section 4.3 and Buyer's rights of offset and recoupment.

4.  RECOURSE AND REPURCHASE OBLIGATIONS.
     4.1      RECOURSE. Buyer's acquisition of Purchased Receivables from Seller
              shall be with full recourse against Seller. In the event the
              Obligations exceed the amount of Purchased Receivables and
              collateral, Seller shall be liable for any deficiency.
     4.2      SELLER'S AGREEMENT TO REPURCHASE.  Seller agrees to pay to Buyer 
              on demand, the full face amount, or any unpaid portion, of any 
              Purchased
              Receivable:
              (A) which remains unpaid ninety (90) calendar days after the 
                  invoice date; or
              (B) which is owed by any Account Debtor who has filed, or has had
                  filed against it, any bankruptcy case, assignment for the
                  benefit of creditors, receivership, or insolvency proceeding
                  or who is generally not paying its debts as such debts become
                  due; or
              (C) with respect to which there has been any breach of warranty of
                  representation set forth in Section 6 hereof or any breach of
                  any covenant contained in this Agreement; or
              (D) with respect to which the Account Debtor asserts any discount,
                  allowance, return, dispute, counterclaim, offset, defense,
                  right of recoupment, right of return, warranty claim, or short
                  payment;
              together with all reasonable attorneys' and professional fees and
              expenses and all court costs incurred by Buyer in collecting such
              Purchased Receivable and/or enforcing its rights under, or
              collecting amounts owned by Seller in connection with, this
              Agreement (collectively, the "Repurchase Amount").
     4.3.     SELLER'S PAYMENT OF THE REPURCHASE AMOUNT OR OTHER AMOUNTS DUE
              BUYER. When any Repurchase Amount or other amount owing to Buyer
              becomes due, Buyer shall inform Seller of the manner of payment
              which may be any one or more of the following in Buyer's sole
              discretion: (a) in cash immediately upon demand therefor; (b) by
              delivery of substitute invoices and an Invoice Transmittal
              acceptable to Buyer which shall thereupon become Purchased
              Receivables; (c) by adjustment to the Reserve pursuant to Section
              3.5 hereof; (d) by deduction from or offset against the amount
              that otherwise would be forwarded to Seller in respect of any
              further Advances that may be made by Buyer; or (f) by any
              combination of the foregoing as Buyer may from time to time
              choose.
     4.4.     SELLER'S AGREEMENT TO REPURCHASE RECEIVABLES. Upon and after the
              occurrence of an Event of Default, Seller shall, upon Buyer's
              demand (or, in the case of an Event of Default under Section 9(B),
              immediately without notice or demand from Buyer) repurchase all
              the Purchased Receivables then outstanding, or such portion
              thereof as Buyer may demand. Such demand may, at Buyer's option,
              include and Seller shall 

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<PAGE>
 
              pay to Buyer Immediately upon demand, cash in an amount equal to
              the Advance with respect to each Purchased Receivable then
              outstanding together will all accrued Finance Charges,
              Adjustments, Administrative Fees, attorney's and professional
              fees, court costs and expenses as provided for herein, and any
              other Obligations. Upon receipt of payment in full of the
              Obligations, Buyers shall immediately instruct Account Debtors to
              pay Seller directly, and return to Seller any Refund due to
              Seller. For the purpose of calculating any Refund due under this
              Section only, the Reconciliation Date shall be deemed to be the
              date Buyer receives payment in good funds of all the Obligations
              as provided in this Section 4.4.

5.   POWER OF ATTORNEY. Seller does hereby irrevocably appoint Buyer and its
     successors and assigns as Seller's true and lawful attorney in fact, and
     hereby authorizes Buyer, regardless of whether there has been as Event of
     Default, (a) to sell, assign, transfer, pledge, compromise, or discharge
     the whole or any part of the Purchased Receivables; (b) to demand, collect,
     receive, sue, and give releases to any Account Debtor for the monies due or
     which may become due upon or with respect to the Purchased Receivables and
     to compromise, prosecute, or defend any action, claim, case or proceeding
     relating to the Purchased Receivables, including the filing of a claim or
     the voting of such claims in any bankruptcy case, all in Buyer's name or
     Seller's name, as Buyer may choose (c) to prepare, file and sign Seller's
     name in any notice, claim, assignment, demand, draft, or notice of or
     satisfaction of lien or mechanics' lien or similar document with respect to
     Purchased Receivables;(d) to notify all Account Debtors with respect to the
     Purchased Receivables to pay directly;(e) to receive, open and dispose of
     all mail addressed to Seller for the purpose of collecting the Purchased
     Receivables;(f) to endorse Seller's name on any check or other forms of
     payment on the Purchased Receivables; (g) to execute on behalf of Seller
     any and all instruments, documents, financing statements and the like to
     perfect Buyer's interest in the Purchased Receivables and Collateral; and
     (h) to do all acts and things necessary or expedient, in furtherance of any
     such purposes. If Buyer receives a check or item which is payment for both
     a Purchased Receivable and another receivable, the funds shall first be
     applied to the Purchased Receivable and, so long as there does not exist an
     Event of Default or an event that with notice, lapse of time or otherwise
     would constitute an Event of Default, the excess shall be remitted to
     Seller. Upon the occurrence and continuation of an event of Default, all of
     power of attorney rights granted by Seller to Buyer hereunder shall be
     applicable with respect to all Purchased Receivables and all Collateral.

6.   REPRESENTATIONS, WARRANTIES AND COVENANTS
     6.1      RECEIVABLES' WARRANTIES, REPRESENTATIONS AND COVENANTS. To induce
              Buyer to buy receivables and to render its services to Seller, and
              with full knowledge that the truth and accuracy of the following
              are being relied upon by the Buyer in determining whether to
              accept receivables as Purchased Receivables, Seller represents,
              warrants, covenants and agrees, with respect to each Invoice
              Transmittal delivered to Buyer and each receivable described
              therein, that: 


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<PAGE>
 
              (A) Seller is the absolute owner of each receivable set forth in
                  the Invoice Transmittal and legal rights to sell, transfer and
                  assign such receivables;
              (B) The correct amount of each receivables is as set forth in the 
                  Invoice Transmittal and is not in dispute;
              (C) The payment of each receivable is not contingent upon the
                  fulfillment of any obligation or contract, past or future and
                  any and all obligations required of the Seller have been
                  fulfilled as of the date of the Invoice Transmittal;
              (D) Each receivable set forth on the Invoice Transmittal is based
                  on an actual sale and delivery of goods and/or services
                  actually rendered, is presently due and owing to Seller, is
                  not past due or in default, has not been previously sold,
                  assigned, transferred, or pledged, and is free of any and all
                  liens, security interests and encumbrances other than liens,
                  security interests or encumbrances in favor of Buyer or any
                  other division or affiliate of Silicon Valley Bank;
              (E) There are no defenses, offsets, or counterclaims against any
                  of the receivables, and no agreement has been made under which
                  the Account Debtor may claim any deduction or discount, except
                  as otherwise stated in the Invoice Transmittal;
              (F) Each Purchased Receivable shall be the property of the Buyer
                  and shall be collected by Buyer, but if for any reason it
                  should be paid to the Seller, Seller shall promptly notify
                  Buyer of such payment, shall hold checks, drafts, or monies so
                  received in trust for the benefit of Buyer, and shall promptly
                  transfer and deliver the same to the Buyer;
              (G) Buyer shall have the right of endorsement, and also the right
                  to require endorsement by Seller, on all payments received in
                  connection with each Purchased Receivable and any proceeds of
                  Collateral;
              (H) Seller, and to Seller's best knowledge , each Account Debtor
                  set forth in the Invoice Transmittal, are and shall remain
                  solvent as that term is defined in the United States
                  bankruptcy Code and the California Uniform Commercial Code,
                  and no such Account Debtor has filed or had filed against it a
                  voluntary petition for relief under the United States
                  Bankruptcy Code;
              (I) Each Account Debtor named on the Invoice Transmittal will not
                  object to the payment for, or the quality or the quantity of
                  the subject matter of, the receivable and is liable for the
                  amount set forth on the Invoice Transmittal;
              (J) Each Account Debtor shall promptly be notified, after
                  acceptance by Buyer, that the Purchased Receivable has been
                  transferred to and is payable to Buyer, and Seller shall not
                  take or permit any action to countermand such notification;
                  and
              (K) All receivables forwarded to and accepted by Buyer after the
                  date hereof, and thereby becoming Purchased Receivables, shall
                  comply with each and every one of the foregoing
                  representations, warranties, covenants and agreements referred
                  to above in this Section 6.1
     6.2      ADDITIONAL WARRANTIES, REPRESENTATIONS AND COVENANTS. In addition
              to the foregoing warranties, representation and covenants, to
              induce Buyer to buy 

                                       83
<PAGE>
 
              receivables and to render its services to Seller, hereby Seller
              represents, warrants, covenants and agrees that: 
              (A) Seller will not assign, transfer, sell, or grant, or permit
                  any lien or security interest any Purchased Receivables or
                  Collateral to or favor of any other party, without Buyer's
                  prior written consent;
              (B) The Seller's name, form of organization, chief executive
                  office, and the place where records concerning all Purchased
                  Receivables and Collateral are kept is set forth at the
                  beginning of this Agreement, Collateral is located only at the
                  location set forth in the beginning of this Agreement, or, if
                  located at any additional location, as set forth on a schedule
                  attached to this Agreement, and Seller will give Buyer at
                  least thirty (30) days prior written notice if such name,
                  organization, chief executive office or other locations of
                  Collateral or records concerning Purchased Receivables or
                  Collateral is changed or added and shall execute any documents
                  necessary to perfect Buyer's interest in the Purchased
                  Receivables and the Collateral;
              (C) Seller shall(i) pay all of its normal gross payroll for
                  employees, and all federal and state taxes, as and when due,
                  including without limitation all payroll and withholding taxes
                  and state sales taxes; (ii) deliver at any time and from time
                  to time at Buyer's request, evidence satisfactory to Buyer
                  that all such amounts have been paid to the proper taxing
                  authorities: and; (iii) if requested by Buyer, pay its payroll
                  and related taxes through the bank or any independent payroll
                  service acceptable Buyer.
              (D) Seller has not, as of the time Seller delivers to Buyer an
                  Invoice Transmittal or as of the time Seller accepts any
                  Advance from Buyer, filed a voluntary petition for relief
                  under the United States Bankruptcy Code or had filed against
                  it an involuntary petition for relief:
              (E) If Seller owns, holds or has any interest in, any copyrights
                  (whether registered, or unregistered), and licenses of any of
                  the foregoing, such interest has been disclosed to Buyer and
                  specifically listed and identified on a schedule to this
                  Agreement, and Seller shall immediately notify Buyer if Seller
                  hereafter obtains any interest in any additional copyrights,
                  or licenses that are significant in value or are material it
                  the conduct of its business; and
              (F) Seller shall provide Buyer with a Compliance Certificate (i)
                  on a quarterly basis to be received by Buyer no later than the
                  fifth calendar day following each calendar quarter, and; (ii)
                  on a more frequent or other basis if and as requested by
                  Buyer.

7.   ADJUSTMENTS. In the event of a breach of any of the representations
     warranties or covenants set forth in Section 6.1, or in the event any
     Adjustment or dispute is asserted by any Account Debtor, Seller shall
     promptly advise Buyer and shall, subject to the Buyer's approval, resolve
     such disputes and advise Buyer of any adjustments. Unless the disputed
     Purchased Receivable is repurchased by Seller and the full Repurchase
     Amount is paid, Buyer shall remain the absolute owner of any Purchased
     Receivable which is subject to Adjustment or 

                                       84
<PAGE>
 
     repurchased under Section 4.2 hereof, and any rejected, returned, or
     recovered personal property, with the right to take possession thereof at
     any time. If such possession is not taken by Buyer, Seller is to resell it
     for the Buyer's account at Seller's expense with the proceeds made payable
     to Buyer. While Seller retains possession of said returned goods, Seller
     shall segregate said goods and mark them "property of Silicon Valley
     Financial Services."

8.   SECURITY INTEREST. To secure the prompt payment and performance to Buyer of
     all Obligations, Seller hereby grants to Buyer a continuing lien upon and
     security interest in all of Seller's now existing or hereafter arising
     rights and interest in the following, whether now owned or existing or
     hereafter created, acquired, or arising and wherever located (collectively,
     the "Collateral"):
              (A) All accounts, receivables, contract rights, chattel paper,
                  instruments, documents, letters of credit, bankers
                  acceptances, drafts, checks, cash, securities, and general
                  intangibles ( including, without limitation, all claims,
                  causes of action, deposit accounts, guaranties, rights in and
                  claims under insurance policies ( including rights to premium
                  refunds), rights to tax refunds, copyrights, rights in and
                  under license agreements and all other intellectual property
                  excluding patents and trademarks);
              (B) All Inventory, including Seller's rights to any returned or
                  rejected goods, with respect to which Buyer shall have all the
                  rights of any unpaid seller, including the rights of repelvin,
                  claim and delivery, reclamation, and stoppage in transit;
              (C) All monies, refunds and other amounts due Seller, including,
                  without limitation, amounts due Seller under this Agreement (
                  including Seller's right of offset and recoupment);
              (D) All equipment, machinery, furniture, furnishing, fixtures,
                  tools, supplies and motor vehicles; 
              (E) All farm products, crops, timber, minerals and the like
                  (including oil and gas);
              (F) All accessions to, substitutions for, and replacements of all
                  of the foregoing;
              (G) All books and records pertaining to all of the foregoing; and
              (H) All proceeds of the foregoing, whether due to voluntary or
                  involuntary disposition, including insurance proceeds.
     Seller is not authorized to sell, assign, transfer or otherwise convey any
     Collateral without Buyer's prior written consent, except for the sale of
     finished inventory in the Seller's usual course of business. Seller agrees
     to sign UCC financing statements, in a form acceptable to Buyer, and any
     other instruments and documents requested by Buyer to evidence, perfect, or
     protect the interests of Buyer in the Collateral. Seller agrees to deliver
     to Buyer the originals of all instruments, chattel paper and documents
     evidencing or related to Purchased Receivables and Collateral.

9.  DEFAULT.  The occurrence of any one or more of the following shall 
              constitute an Event of Default here under.
              (A) Seller fails to pay any amount owed to Buyer as and when due;

                                       85
<PAGE>
 
              (B) There shall be commenced by or against Seller any voluntary or
                  involuntary case under the United States Bankruptcy Code, or
                  any assignment for the benefit of creditors, or appointment of
                  a receiver or custodian for any of its assets;
              (C) Seller shall become insolvent in that its debts are greater
                  than the fair value of its assets, or Seller is generally not
                  paying its debts as they become due or is left with
                  unreasonably small capital;
              (D) Any involuntary lien, garnishment, attachment or the like is
                  issued against or attaches to the Purchased Receivables or any
                  Collateral;
              (E) Seller shall breach any covenant, agreement, warranty, or
                  representation set forth herein, and the same is not cured to
                  Buyer's satisfaction within ten (10) days after Buyer has
                  given Seller oral or written notice thereof; provided, that if
                  such breach is incapable of being cured it shall constitute an
                  immediate default hereunder;
              (F) Seller is not in compliance with, or otherwise is in default
                  under, any term of any document, instrument or agreement
                  evidencing a debt, obligation or liability of any kind or
                  character of Seller, now or hereafter existing, in favor of
                  Buyer or any division or affiliate of Silicon Valley Bank,
                  regardless of whether such debt, obligation or liability is
                  direct or indirect, primary or secondary, joint, several or
                  joint and several, or fixed or contingent, together with any
                  and all renewals and extensions of such debts, obligations and
                  liabilities, or any part thereof;
              (G) An event of default shall occur under any guaranty executed by
                  any guarantor of the Obligations of Seller to Buyer under this
                  Agreement, or any material provision of any such guaranty
                  shall for any reason cease to be valid or enforceable or any
                  such guaranty shall be repudiated or terminated, including by
                  operation of law;
              (H) A default or event of default shall occur under any agreement
                  between Seller and any creditor of Seller that has entered
                  into a subordination agreement with Buyer; or
              (I) Any creditor that has entered into a subordination agreement
                  with Buyer shall breach any of the terms or not comply with
                  such subordination agreement.

10.  REMEDIES UPON DEFAULT. Upon the occurrence of an Event of Default, (1)
     without implying any obligation to buy receivables, Buyer may cease buying
     receivables or extending any financial accommodations to Seller; (2) all or
     a portion of the Obligations shall be, at the option and upon demand by
     Buyer, or with respect to an Event of Default described in Section 9(B),
     automatically and without notice or demand, due and payable in full; and
     (3) Buyer shall have and may exercise all the rights and remedies under
     this Agreement and under applicable law, including the rights and remedies
     of a secured party under the California Uniform Commercial Code all the
     power of attorney rights described in Section 5 with respect to all
     Collateral, and the right to collect, dispose of, sell, lease, use, and
     realize upon all Purchased Receivables and all Collateral in any commercial
     reasonable manner. Seller and Buyer agree that any notice of sale required
     to be given to Seller shall be deemed to be reasonable if given five (5)
     days prior to the date on or after which the sale may be held. 

                                       86
<PAGE>
 
     In the event that the Obligations are accelerated hereunder, Seller shall
     repurchase all of the Purchased Receivables as set forth in Section 4.4.

11.  ACCRUAL OF INTEREST. If any amount owed by Seller hereunder is not paid
     when due, including, without limitation, amounts due under Section 3.5,
     Repurchase Amounts, amounts due under Section 12, and any other
     Obligations, such amounts shall bear interest at a per annum rate equal to
     the per annum rate of the Finance Charges until the earlier of (i) payment
     in good funds or (ii) entry of a final judgment thereof, at which time the
     principal amount of any money judgment remaining unsatisfied shall accrue
     interest at the highest rate allowed by applicable law.

12.  FEES, COSTS AND EXPENSES; INDEMNIFICATION. The Seller will pay to Buyer
     immediately upon demand all fees, costs and expenses (including fees of
     attorneys and professionals and their costs and expenses) that Buyer incurs
     or may from time to time impose in connection with any of the following:
     (a) preparing, negotiating, administering, and enforcing this Agreement or
     any other agreement executed in connection herewith, including any
     amendments, waivers or consents in connection with any of the foregoing,
     (b) any litigation or dispute (whether instituted by Buyer, Seller or any
     other person) in any way relating to the Purchased Receivables, the
     Collateral, this agreement or any other agreement executed in connection
     herewith or therewith, (d) enforcing any rights against Seller or any
     guarantor, or any Account Debtor, (e) protecting or enforcing its interest
     in the Purchased Receivables or the Collateral, (f) collecting the
     Purchased Receivables and the Obligations, and (g) the representation of
     Buyer in connection with any bankruptcy case or insolvency proceedings
     involving Seller, any Purchased Receivable, the Collateral, any Account
     Debtor, or any guarantor. Seller shall indemnify and hold Buyer harmless
     from and against any and all claims, actions, damages, costs, expenses, and
     liabilities of any nature whatsoever arising in connection with any of the
     foregoing.

13.  SEVERABILITY, WAIVER, AND CHOICE OF LAW. In the event that any provision of
     this Agreement is deemed invalid by reason of law, this Agreement will be
     construed as not containing such provision and the remainder of the
     Agreement shall remain in full force and effect. Buyer retains all of its
     rights, even if it makes an Advance after default. If Buyer waives a
     default, it may enforce a later default. Any consent or waiver under, or
     amendment of, this Agreement must be in writing. Nothing contained herein,
     or any action taken or not taken by Buyer at any time, shall be construed
     at any time to be indicative of any obligation or willingness on the part
     of Buyer to amend this Agreement or to grant to Seller any waivers or
     consents. This Agreement has been transmitted by Seller to Buyer at Buyer's
     office in the State of California and has been executed and accepted by
     Buyer in the State of California. This Agreement shall be governed by and
     interpreted in accordance with the internal laws of the State of
     California.

                                       87
<PAGE>
 
14.  ACCOUNT COLLECTION SERVICES. Certain Account Debtors may require or prefer
     that all of Seller's receivables be paid to the same address and/or party,
     or Seller and Buyer may agree that all receivables with respect to certain
     Account Debtors be paid to one party. In such event Buyer and Seller may
     agree that Buyer shall collect all receivables whether owned by Seller or
     Buyer and (provided that there does not then exist an Event of Default or
     event that with notice, lapse or time or otherwise would constitute an
     Event of Default, and subject to Buyer's rights in the Collateral) Buyer
     agrees to remit to Seller the amount of the receivables collections it
     receives with respect to receivables other than Purchased Receivables. It
     is understood and agreed by Seller that this Section does not impose any
     affirmative duty on Buyer to do any act other than to turn over such
     amounts. All such receivables and collections are Collateral and in the
     event of Seller's default hereunder, Buyer shall have no duty to remit
     collections of Collateral and may apply such collections to the obligations
     hereunder and Buyer shall have the rights of a secured party under the
     California Uniform Commercial Code.

15.  NOTICES. All notices shall be given to Buyer and Seller at the addresses or
     faxes set forth on the first page of this Agreement and shall be deemed to
     have been delivered and received: (a) if mailed, three(3) calendar days
     after deposited in the United Stated mail, first class, postage pre-paid,
     (b) one (1) calendar day after deposit with an overnight mail or messenger
     service; or (c) on the same date of confirmed transmission if sent by hand
     delivery, telecopy, telefax or telex.

16.  JURY TRIAL. SELLER AND BUYER EACH HEREBY (a) WAIVE THEIR RESPECTIVE RIGHTS
     TO A JURY TRIAL ON ANY CLAIM OR ACTION ARISING OUT OF OR IN CONNECTION WITH
     THIS AGREEMENT, ANY RELATED AGREEMENTS, OR ANY OF THE TRANSACTIONS
     CONTEMPLATED HEREBY OR THEREBY; (b) RECOGNIZE AND AGREE THAT THE FOREGOING
     WAIVER CONSTITUTES A MATERIAL INDUCEMENT FOR IT TO ENTER INTO THIS
     AGREEMENT; AND (c) REPRESENT AND WARRANT THAT IT HAS REVIEWED THIS WAIVER,
     HAS DETERMINED FOR ITSELF THE NECESSITY TO REVIEW THE SAME WITH ITS LEGAL
     COUNSEL, AND KNOWINGLY AND VOLUNTARILY WAIVES ALL RIGHTS TO A JURY TRIAL.

17.  TERM AND TERMINATION. The term of this Agreement shall be for one (1) year
     from the date hereof, and from year to year thereafter unless terminated in
     writing by Buyer or Seller. Seller and Buyer shall each have the right to
     terminate this Agreement at any time. Notwithstanding the foregoing, any
     termination of this Agreement shall not affect Buyer's security interest in
     the Collateral and Buyer's ownership of the Purchased Receivables and this
     Agreement shall continue to be effective and Buyer's rights and remedies
     hereunder shall survive such termination, until all transactions entered
     into and Obligations incurred hereunder or in connection herewith have been
     completed and satisfied in full.

                                       88
<PAGE>
 
18.  TITLES AND SECTION HEADINGS. The titles and section headings used herein
     are for convenience only and shall not be used in interpreting this
     Agreement.

19.  OTHER AGREEMENTS. The terms and provision of this Agreement shall not
     adversely affect the rights of Buyer or any other division or affiliate of
     Silicon Valley Bank under any other document, instrument or agreement. The
     terms of such other documents, instruments and agreements shall remain in
     full force and effect notwithstanding the execution of this Agreement. In
     the event of a conflict between any provision of this Agreement and any
     provision of any other document, instrument or agreement between Seller on
     the one hand, and Buyer or any other division or affiliate of Silicon Valey
     Bank on the other hand, Buyer shall determine in its sole discretion which
     provision shall apply. Seller acknowledges specifically that any security
     agreements, liens and/or security interests currently securing payment of
     any obligations of Seller owing to Buyer or any other division or affiliate
     of Silicon Valley Bank also secure Seller's obligations under Agreement,
     and are valid and subsisting and are not adversely affected by execution of
     this Agreement. Seller further acknowledges that (a) any collateral under
     other outstanding security agreements or other documents between Seller and
     Buyer or any other division or affiliate of Silicon Valley Bank secures the
     obligations of Seller under this Agreement and (b) a default by Seller
     under this Agreement constitutes a default under other outstanding
     agreements between Seller and Buyer or any other division or affiliate of
     Silicon Valley Bank.

                                       89
<PAGE>
 
IN WITNESS WHEREOF, Seller and Buyer have executed this Agreement on the day and
year above written.

SELLER: OXIS INTERNATIONAL, INC.            SELLER: OXIS ACQUISITION CORPORATION

By       s/Jon S. Pitcher                   By       s/Jon S. Pitcher
         ----------------------                      --------------------

Title    C.F.O. and Secretary               Title    C.F.O.
         ----------------------                      --------------------



BUYER: SILICON VALLEY FINANCIAL SERVICES
       A division of Silicon Valley Bank

By
   ------------------------------

Title
      ---------------------------

                                       90

<PAGE>
 
                                 EXHIBIT 21 (A)

                    SUBSIDIARIES OF OXIS INTERNATIONAL, INC.


As of December 31, 1996, the Company's subsidiaries were as follows:

             Name                           Jurisdiction of incorporation
             ----                           -----------------------------

     OXIS International S.A.                         France
     OXIS Acquisition Corporation                    Delaware
     OXIS Isle of Man Limited                        Isle of Man

                                       91

<PAGE>
 
                                   EXHIBIT 23


                          INDEPENDENT AUDITORS' CONSENT


We consent to the incorporation by reference in Registration Statement No.
33-64451 on Form S-8 and in Registration Statements Nos. 33-61087, 333-5921, and
333-18041 on Form S-3 of our report dated March 7, 1997 (which expresses an
unqualified opinion and includes an explanatory paragraph relating to the
Company's ability to continue as a going concern) appearing in this Annual
Report on Form 10-K of OXIS International, Inc. for the year ended December 31,
1996.


DELOITTE & TOUCHE LLP
Portland, Oregon

March 25, 1997

                                       92

<TABLE> <S> <C>

<PAGE>
 
<ARTICLE> 5
       
<S>                             <C>
<PERIOD-TYPE>                   12-MOS
<FISCAL-YEAR-END>                          DEC-31-1996
<PERIOD-START>                             JAN-01-1996
<PERIOD-END>                               DEC-31-1996
<CASH>                                         422,000
<SECURITIES>                                         0
<RECEIVABLES>                                  861,000
<ALLOWANCES>                                         0
<INVENTORY>                                    591,000
<CURRENT-ASSETS>                             2,065,000
<PP&E>                                       1,327,000
<DEPRECIATION>                                       0
<TOTAL-ASSETS>                               7,997,000
<CURRENT-LIABILITIES>                        3,470,000
<BONDS>                                              0
                                0
                                     23,000
<COMMON>                                     6,895,000
<OTHER-SE>                                    (76,000)
<TOTAL-LIABILITY-AND-EQUITY>                 7,997,000
<SALES>                                      4,802,000
<TOTAL-REVENUES>                             4,867,000
<CGS>                                        3,009,000
<TOTAL-COSTS>                                3,009,000
<OTHER-EXPENSES>                             4,908,000
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                             138,000
<INCOME-PRETAX>                            (5,992,000)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                        (5,992,000)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                               (5,992,000)
<EPS-PRIMARY>                                    (.47)
<EPS-DILUTED>                                        0
        

</TABLE>


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