OXIS INTERNATIONAL INC
DEFR14A, 1999-10-19
PHARMACEUTICAL PREPARATIONS
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<PAGE>

                                UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549

                           SCHEDULE 14A INFORMATION

          Proxy Statement Pursuant to Section 14(a) of the Securities
                    Exchange Act of 1934 (Amendment No.  )

Filed by the Registrant [X]

Filed by a Party other than the Registrant [_]

Check the appropriate box:

[_]  Preliminary Proxy Statement         [_]  CONFIDENTIAL, FOR USE OF THE
                                              COMMISSION ONLY (AS PERMITTED BY
                                              RULE 14A-6(E)(2))

[X]  Definitive Proxy Statement

[_]  Definitive Additional Materials

[_]  Soliciting Material Pursuant to Section 240.14a-11(c) or Section 240.14a-12

                           Oxis International, Inc.
- --------------------------------------------------------------------------------
               (Name of Registrant as Specified In Its Charter)


- --------------------------------------------------------------------------------
   (Name of Person(s) Filing Proxy Statement, if other than the Registrant)


Payment of Filing Fee (Check the appropriate box):

[X]  No fee required

[_]  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.


     (1) Title of each class of securities to which transaction applies:

     -------------------------------------------------------------------------


     (2) Aggregate number of securities to which transaction applies:

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     (3) Per unit price or other underlying value of transaction computed
         pursuant to Exchange Act Rule 0-11 (Set forth the amount on which
         the filing fee is calculated and state how it was determined):

     -------------------------------------------------------------------------


     (4) Proposed maximum aggregate value of transaction:

     -------------------------------------------------------------------------


     (5) Total fee paid:

     -------------------------------------------------------------------------

[_]  Fee paid previously with preliminary materials.

[_]  Check box if any part of the fee is offset as provided by Exchange
     Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee
     was paid previously. Identify the previous filing by registration statement
     number, or the Form or Schedule and the date of its filing.

     (1) Amount Previously Paid:

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     (2) Form, Schedule or Registration Statement No.:

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     (3) Filing Party:

     -------------------------------------------------------------------------


     (4) Date Filed:

     -------------------------------------------------------------------------

Notes:
<PAGE>

                           OXIS INTERNATIONAL, INC.
                       6040 N. Cutter Circle, Suite 317
                            Portland, Oregon 97217

                   NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

                               December 2, 1999

     NOTICE IS HEREBY GIVEN that the Annual Meeting of Stockholders of OXIS
International, Inc., a Delaware corporation ("OXIS" or the "Company"), will be
held at the Fifth Avenue Suites Hotel, 506 S.W. Washington, Portland, Oregon
97205, on Thursday, December 2, 1999 at 1:30 p.m. (local time), for the
following purposes:

     1.   To elect a Board of six (6) directors to serve for the ensuing year
          and until their successors are elected.

     2.   To approve an amendment of the Company's 1994 Stock Incentive Plan to
          increase the number of shares of common stock available for issuance
          thereunder by 525,000 shares, to an aggregate of 1,365,000 shares.

     3.   To transact such other and further business as may properly come
          before the meeting or adjournment or adjournments thereof.

     Common stockholders and holders of Series B and Series C Preferred Stock of
record at the close of business on October 8, 1999, are entitled to notice of
and to vote at the meeting. A complete list of such stockholders is open to
examination by any stockholder for any purpose germane to the meeting, during
ordinary business hours, at the offices of the Company, located at 6040 N.
Cutter Circle, Suite 317, Portland, Oregon 97217.

     Copies of the Company's Annual Report on Form 10-K and an amendment thereto
on Form 10-K/A for the fiscal year ended December 31, 1998, are either enclosed
herewith or have previously been delivered to you.

                                        By Order of the Board of Directors


                                        /s/ Jon S. Pitcher
                                        Jon S. Pitcher, Secretary

Dated: October 18, 1999

     You are urged to fill in, sign, date and mail the enclosed Proxy as soon as
possible. If you attend the meeting and vote in person, the Proxy will not be
used. If the Proxy is mailed in the United States in the enclosed envelope, no
postage is required. The prompt return of your Proxy will save the expense
involved in further communication.
<PAGE>

                           OXIS INTERNATIONAL, INC.
                       6040 N. Cutter Circle, Suite 317
                            Portland, Oregon 97217
                                                                October 18, 1999
                                PROXY STATEMENT

                      for Annual Meeting of Stockholders
                        to be held on December 2, 1999

This Proxy Statement is furnished to you in connection with the solicitation by
the Board of Directors of OXIS International, Inc., a Delaware corporation
("OXIS" or the "Company"), of Proxies in the accompanying form to be used at the
Annual Meeting of Stockholders ("Meeting") to be held at the Fifth Avenue Suites
Hotel, 506 S.W. Washington, Portland, Oregon 97205, on Thursday, December 2,
1999 at 1:30 p.m. (local time) and at any subsequent time which may be necessary
by the adjournment thereof.

If you were a holder of record of Common Stock, Series B Preferred Stock or
Series C Preferred Stock of the Company (the "Voting Stock") at the close of
business on October 8, 1999, you are entitled to vote at the Meeting and your
presence is desired. However, to assure your representation at the Meeting, you
are urged by the Board of Directors of the Company to sign and return the
enclosed Proxy as soon as possible. You can, of course, revoke your Proxy at any
time before it is voted if you so desire, either in person at the meeting or by
delivery of a duly executed written statement to that effect delivered to the
Secretary of the Company.

The Company is paying all costs of the solicitation of Proxies, including the
expenses of printing and mailing to its stockholders this Proxy Statement, the
accompanying Notice of Annual Meeting of Stockholders and form of Proxy and the
Annual Report on Form 10-K and 10-K/A for the fiscal year ended December 31,
1998. The Company will also reimburse brokerage houses and other custodians,
nominees and fiduciaries for their expenses, in accordance with the regulations
of the Securities and Exchange Commission, in sending Proxies and Proxy
materials to the beneficial owners of the Company's Common Stock. Officers or
employees of the Company may also solicit Proxies in person, or by mail,
telegram or telephone, but such persons will receive no compensation for such
work, other than their normal compensation as officers or employees.

At the close of business on October 8, 1999, 7,928,344 shares of Common Stock,
428,389 shares of Series B Preferred Stock and 608,536 shares of Series C
Preferred Stock were outstanding. Shares of Series B and Series C Preferred
Stock are entitled to vote at the Annual Meeting. Each share of Common Stock
outstanding as of October 8, 1999, is entitled to one vote. Each share of Series
B Preferred Stock outstanding as of October 8, 1999, is entitled to .20 votes.
Each share of Series C Preferred Stock outstanding as of October 8, 1999, is
entitled to the number of votes equal to the number of shares of Common Stock
into which the Series C Preferred share is convertible times 1.30 divided by the
average closing bid price of the Company's Common Stock during the fifteen (15)
consecutive trading days immediately prior to the date such share of Series C
Preferred Stock was purchased. As of the record date, each share of Series C
Preferred Stock is entitled to .216 - .229 votes, resulting in a total of
133,259 votes for all of the Series C Preferred Stock outstanding. This Proxy
Statement and the enclosed Proxy are first being mailed to the stockholders of
the Company on or about October 18, 1999.

                           PROPOSALS OF STOCKHOLDERS

Proposals of stockholders intended to be presented at the 2000 Annual Meeting of
Stockholders must be received at the Company's executive offices on or before
January 9, 2000, for inclusion in the Company's Proxy Statement with respect to
such meeting.
<PAGE>

                           PROXIES AND VOTE REQUIRED

Proxies

The persons named as Proxies for the Meeting in the enclosed proxy card (Ray R.
Rogers, Chairman of the Board and Chief Executive Officer and Stuart S. Lang,
member of the Company's Board of Directors) were selected by OXIS' Board of
Directors.

Voting of Proxies

All properly executed Proxies that are not revoked will be voted at the Meeting
in accordance with the instructions contained therein. Proxies containing no
instructions regarding the proposals specified in the form of Proxy will be
voted FOR approval of all proposals in accordance with the recommendation of the
Board of Directors of the Company. Any stockholder signing a Proxy has the power
to revoke it prior to the Meeting, or at the Meeting, prior to the vote pursuant
to the Proxy. A Proxy may be revoked by delivering a written notice of
revocation or a duly executed Proxy bearing a later date or by attending the
Meeting and voting in person.

Vote Required

The election of directors requires a plurality of the votes of the shares of
Voting Stock present in person or represented by Proxy and entitled to vote
thereon. If a quorum is present those nominees receiving a plurality of the
votes cast will be elected. Accordingly, shares not voted in the election of
directors (including shares covered by a Proxy as to which authority is withheld
to vote for all nominees) and shares not voted for any particular nominee
(including shares covered by a Proxy as to which authority is withheld to vote
for only one or less than all of the identified nominees) will not prevent the
election of any of the nominees for director. Approval of the proposal to adopt
the amendment to the 1994 Stock Incentive Plan requires the affirmative vote of
the majority of shares of Voting Stock present in person or represented by Proxy
and abstentions will be treated as votes against. For any other matter submitted
to stockholders at the Meeting, if a quorum is present the affirmative vote of
the majority of the shares voted is required for approval. As a result,
abstention votes have the effect of a vote against such matters.

The presence in person or by Proxy of a majority of the votes of the shares of
the Voting Stock outstanding and entitled to vote at the Meeting is required for
a quorum.

Effect of Broker Non-Votes

"Broker Non-Votes" occur when a broker holding shares of stock in street name
withholds its vote on certain non-routine matters because the broker has not
received instructions from the beneficial owner of those shares of stock and
does not have discretionary authority to vote on such non-routine matters
without such instructions. Under the Rules of the National Association of
Securities Dealers, Inc., brokers holding shares of stock in street name must
receive specific instructions from the beneficial owners in order to have the
authority to vote, in person or by Proxy, on certain "non-routine" matters as
defined under those Rules. When a beneficial owner does not give specific
instructions to the broker, the broker, as the holder of record, is entitled to
vote only on "routine" matters and must withhold its votes as to any non-routine
matters. When a Proxy solicitation includes a non-routine proposal and the
broker does not receive specific instructions from the beneficial owner, the
resulting Proxy is considered a "limited Proxy". Shares represented by limited
Proxies are considered present for quorum purposes. However, shares represented
by limited Proxies are not considered present for purposes of determining the
total number of shares with voting power present with regard to a non-routine
proposal. The resulting broker non-vote will not be counted for or against such
non-routine proposal.

                                       2
<PAGE>

Proposal 2 (Amendment of the OXIS 1994 Stock Incentive Plan) is a "non-routine"
proposal. Shares represented by limited Proxies are not considered present for
purposes of determining the total number of shares with voting power present
with regard to this proposal. (Broker non-votes will not be counted for or
against this proposal). Proposal 1 (Election of Directors) is a "routine" matter
upon which brokers can cast votes with or without specific instructions from the
beneficial holders and are thus counted for purposes of determining whether such
Proposal has been approved.


                    PROPOSAL NO. 1 -- ELECTION OF DIRECTORS
                            (Item 1 on Proxy Card)

The Board of Directors of the Company currently consists of six individuals, all
of whom have been nominated for election at the Meeting. Unless otherwise
instructed, the Proxy holders will vote the Proxies held by them for the
Company's six nominees. In the event that any such nominee is unable or declines
to accept nomination or election, the Proxies will be voted for any nominee who
shall be recommended by the present Board of Directors. Directors are to be
elected to hold office until the next Annual Meeting of Stockholders or until
their respective successors shall have been elected and qualified. The names and
ages of the six nominees for director are set forth below:


             Name                    Age          Position
     -----------------------        -----    -------------------

     Ray R. Rogers                   59      Chairman of the Board and
                                              Chief Executive Officer
     Timothy G. Biro                 46      Director
     Richard A. Davis                63      Director
     Brenda D. Gavin, D.V.M.         51      Director
     Stuart S. Lang                  62      Director
     A.R. Sitaraman                  65      Director

THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" THE ELECTION OF THE NOMINEES
LISTED ABOVE TO THE COMPANY'S BOARD OF DIRECTORS.


SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

Beneficial Ownership of Securities

Common Stock
- ------------

The following table sets forth certain information, as of September 30, 1999,
with respect to persons known to the Company to be the beneficial owner of more
than five percent of the Company's Common Stock and beneficial ownership by
directors, director nominees and executive officers of the Company's Common
Stock.

                                       3
<PAGE>

<TABLE>
<CAPTION>
Name and, as                                 Amount and nature     Percent of
appropriate, address                      of beneficial ownership   class/1/
- --------------------                      -----------------------  -----------
<S>                                       <C>                      <C>
Credit Suisse Asset Management Funds
Uraniastrasse 9
P.O. Box 800
8070 Zurich, Switzerland                          920,000/10/            10.97%
                                                          --
Pictet & Cie
29 Bd Georges Favon
P.O. Box 5130
1204 Geneva, Switzerland                          747,985/11/             8.92%
                                                          --
S.R. One Limited
200 Barr Harbor Drive, Suite 250
W. Conshohocken, PA 19428                         586,800/2/              7.13%
                                                          -
Timothy G. Biro                                     7,100/3/4/               *
                                                          ---
Richard A. Davis                                    6,340/3/8/               *
                                                          ---
Dr. Brenda D. Gavin                               586,800/3/5/9/          7.13%
                                                          -----
Stuart S. Lang                                      6,800/3/                 *
                                                          -
Jon S. Pitcher                                     43,525/3/                 *
                                                          -
Humberto V. Reyes                                  50,000/3/                 *
                                                          -
Dr. Timothy C. Rodell                              89,333/3/              1.11%
                                                          -
Ray R. Rogers                                     172,034/3/6/            2.15%
                                                          ---
A.R. Sitaraman                                     13,000/3/7/               *
                                                          ---
Executive officers and directors
  as a group -- 9 persons                         974,932                11.48%
</TABLE>

  * Less than one percent.

/1/  As required by regulations of the Securities and Exchange Commission, the
     number of shares in the table includes shares which can be purchased within
     60 days, or, shares with respect to which a person may obtain voting power
     or investment power within 60 days. Also required by such regulations, each
     percentage reported in the table for these individuals is calculated as
     though shares which can be purchased within 60 days have been purchased by
     the respective person or group and are outstanding.

/2/  The holdings of S.R. One Limited include 428,389 shares of the Company's
     Series B Preferred Stock which are convertible into 85,677 shares of Common
     Stock and warrants exercisable for 207,812 shares of Common Stock. The
     holdings of S.R. One Limited also include 1,600 shares of Common Stock
     owned by Dr. Gavin and 4,000 shares of Common Stock subject to options held
     by Dr. Gavin.

/3/  The holding of directors Davis and Gavin each include 4,000 shares of
     Common Stock subject to options. The holdings of director Lang include
     6,000 shares of Common Stock subject to options. The holdings of directors
     Biro and Sitaraman each include 7,000 shares of Common Stock subject to
     options. The holdings of Jon S. Pitcher include 39,000 shares of Common
     Stock subject to options. The holding of Humberto V. Reyes include 50,000
     shares of Common Stock subject to options. The holdings of Timothy C.
     Rodell include 88,333 shares of Common Stock subject to options. The
     holdings of Ray R. Rogers include 68,066 shares of Common Stock subject to
     options.

/4/  Mr. Biro disclaims beneficial ownership of 5,000 shares of Common Stock
     subject to options.

/5/  Dr. Gavin is President of S.R. One Limited. S.R. One Limited owns 287,711
     shares of Common Stock, 428,389 shares of the Company's Series B Preferred
     Stock, and warrants exercisable for 207,812 shares of Common Stock. The
     holdings of S.R. One Limited are included in Dr. Gavin's holdings, but Dr.
     Gavin disclaims beneficial ownership of the OXIS securities owned by S.R.
     One Limited.

/6/  Included are 2,000 shares of Common Stock owned by his individual
     retirement account, as to which Mr. Rogers exercises voting

                                       4
<PAGE>

     and investment power.

/7/  Mr. Sitaraman's holdings include 3,060 shares of Common Stock owned by his
     SEP-IRA, 1,740 shares of Common Stock owned by his wife's SEP-IRA and 1,200
     shares of Common Stock owned in equal amounts by Mr. Sitaraman's and his
     spouse's individual retirement accounts.

/8/  Mr. Davis' holdings include 1,280 shares of Common Stock owned by Mr. Davis
     jointly with his spouse.

/9/  Dr. Gavin's holdings include 1,600 shares of Common Stock owned by Dr.
     Gavin jointly with her spouse.

/10/ The holdings of Credit Suisse include warrants exercisable for 460,000
     shares of Common Stock.

/11/ The holdings of Pictet & Cie include warrants exercisable for 457,143
     shares of Common Stock.

Series B Preferred Stock
- ------------------------

The following table sets forth certain information, as of September 30, 1999,
with respect to persons known by the Company to be the beneficial owner of more
than five percent of the Company's Series B Preferred Stock.

                                           Amount and nature         Percent of
  Name and address                      of beneficial ownership        class
  ----------------                      -----------------------      ----------

  S.R. One Limited
  200 Barr Harbor Drive, Suite 250
  W. Conshohocken, PA 19428                       428,389             100.00%

Series C Preferred Stock
- ------------------------

The following table sets forth certain information, as of September 30, 1999,
with respect to persons known by the Company to be the beneficial owner of more
than five percent of the Company's Series C Preferred Stock.

<TABLE>
<CAPTION>
                                           Amount and nature         Percent of
  Name and address                      of beneficial ownership        class
  ----------------                      -----------------------      ----------
  <S>                                           <C>                    <C>
  Rauch & Co.
  c/o State Street Bank & Trust
  225 Franklin Street
  Boston, MA 02110                              200,000                 32.87%

  Finovelec S.A.
  6, rue Ancelle
  92521 Neuilly Cedex, France                   155,555                 25.56%

  Sofinnova Capital F.C.P.R.
  51, rue Saint Georges
  75009 Paris, France                            94,051                 15.46%

  American Health Care Fund, L.P.
  2748 Adeline, Suite A
  Berkeley, CA 94703                             77,000                 12.65%

  Sofinnova S.A.
  51, rue St. Georges
  75009 Paris, France                            62,700                 10.30%
</TABLE>

                                       5
<PAGE>

DIRECTORS AND EXECUTIVE OFFICERS OF THE COMPANY

Set forth below is information regarding the directors, nominees and executive
officers of the Company.

Timothy G. Biro

Age:  46

Mr. Biro has been a director of the Company since August 15, 1995. Mr. Biro is
currently the Managing Partner of Ohio Innovation Fund I, L.P., a venture
capital partnership which invests in early-stage technology based businesses. In
addition to being a director of OXIS, Mr. Biro is a member of the board of
directors of Datatrak, Inc.

Mr. Biro was previously a general partner of Brantley Ventures Partners II, L.P.
and Brantley Venture Partners III, L.P.  Prior to joining Brantley Venture
Partners in 1991, Mr. Biro was Superintendent of Pharmaceutical Manufacturing at
Merck & Co., Inc.  Mr. Biro holds B.S. degrees in Microbiology from Pennsylvania
State University and in Pharmacy from Temple University, and an MBA from the
Wharton School of Business.

Richard A. Davis
Age:  63

Mr. Davis has been a member of the Board since January 28, 1998.  Mr. Davis is
currently President and Chief Executive Officer of Pentzer Corporation, a
private investment company and subsidiary of The Washington Water Power Company.
He has 20 years of service with Pacific Northwest Bell (now US West
Communications).  He has served as Chief of Staff to former Washington Governor
Booth Gardner, chief executive of the State of Washington's Department of Labor
and Industries and director of the state's Office of Financial Management.

Mr. Davis received a B.S. degree from the University of Oregon and attended
advanced programs at both the University of Illinois and Stanford University.
He has served as an advisor to the Washington State Investment Board and has
served on the boards of several medical diagnostic companies.  He currently is
on the Board of Regents for Washington State University, serves on the
Washington Technology Alliance Board, and is Past Chair of the Association of
Washington Business.

Brenda D. Gavin, D.V.M.
Age:  51

Dr. Gavin has been a director of the Company since May 9, 1997.  In addition to
being a director of OXIS, Dr. Gavin is a member of the board of Directors of
Synbiotics Corporation.

Dr. Gavin is currently President of S.R. One Limited, the venture capital
subsidiary of SmithKline Beecham. Prior to joining S.R. One, Dr. Gavin was
Director of Business Development for SmithKline Beecham Animal Health Products.
She also held business development positions with IMC in the Chicago area and
previously worked for the Centers for Disease Control in Atlanta, Georgia. Dr.
Gavin holds a B.S. degree from Baylor University, a D.V.M. from the University
of Missouri, and a M.B.A. from the University of Texas-San Antonio.

Stuart S. Lang
Age:  62

Mr. Lang has been a director of the Company since January 19, 1996.

Mr. Lang has worked in the accounting field for over 25 years.  He has been a
tax partner and subsequently partner in charge of the Portland office of a
national CPA firm.  He founded a local accounting firm, The Lang

                                       6
<PAGE>

Group, in Portland, Oregon, in 1985, and was managing member of that firm until
1997 when it combined with Moss Adams, LLP. Mr. Lang currently divides his time
between public accounting and as an officer of a merger and acquisition advisory
company.

Mr. Lang is past Chairman of IA International, an international affiliation of
independent accounting firms.  He has served as a member of AICPA tax
subcommittees, including Responsibilities in Tax Practice, and as chairman of
the OSCPA Taxation and Estate Planning Committees.

Ray R. Rogers
Age:  59

Mr. Rogers has been Chairman of the Board of the Company since May 10, 1993, and
Chief Executive Officer since March 18, 1998. He also served as Chairman of the
Board of Directors of International BioClinical, Inc, ("IBC") from its
organization in 1983 until its merger with the Company in 1994. Mr. Rogers
served as President and Chief Executive Officer of IBC from 1983 until 1992.

Prior to his involvement with IBC, Mr. Rogers was the principal in charge of
consulting services at the Portland, Oregon, office of the international
accounting firm of Arthur Young & Company. Mr. Rogers received his B.S. degree
in Business Administration from California State University, Chico.

A.R. Sitaraman
Age:  65

Mr. Sitaraman has been a director of the Company since May 10, 1993. Mr.
Sitaraman earned an industrial engineering degree prior to graduating from the
Indian Air Force Flying College and embarking upon an 18-year career as a pilot
and instructor in the Indian Air Force.

Mr. Sitaraman is the President and Chief Executive Officer of Sitrex
International, Inc., a corporation involved in development, syndication and
consulting in the real estate industry, in addition to the import and export
business.

Jon S. Pitcher

Age:  50

Mr. Pitcher, a Certified Public Accountant, has been Vice President and Chief
Financial Officer of OXIS since September 7, 1994, and Secretary of the Company
since August 15, 1995. Prior to the merger of IBC with the Company, Mr. Pitcher
was Chief Financial Officer of IBC, a position he had held since 1991.

Prior to joining IBC, Mr. Pitcher was a partner in the international accounting
firm, Ernst & Young, specializing in services to health care clients.  Mr.
Pitcher received his B.S. degree in Business Administration from Pepperdine
University and his M.S. degree in Management from UCLA.

Humberto V. Reyes

Age:  54

Effective March 18, 1998, Mr. Reyes was appointed President of OXIS Health
Products, Inc., a newly-formed subsidiary of the Company. Mr. Reyes joined the
Company in August 1997 as Senior Vice President. Prior to joining OXIS, Mr.
Reyes was Chief Executive Officer of BPR Health International, a start up
company involved in alternative health care products. Previous to BPR Health
International, Mr. Reyes was Vice President and General Manager of the
Chromatography Division of Varian & Associates. Mr. Reyes received a B.S. in
Chemistry from the University of Puerto Rico.

                                       7
<PAGE>

Timothy C. Rodell, M.D.
Age:  48

Dr. Rodell was Chief Operating Officer of the Company from March 1, 1996 until
March 18, 1998 when he was appointed President of OXIS Therapeutics, Inc., a
newly-formed subsidiary of the Company. Dr. Rodell is also President of OXIS
International S.A. Prior to joining OXIS, Dr. Rodell spent ten years with
Cortech, Inc., a Denver-based biopharmaceutical company, where he was most
recently Executive Vice President of Operations and Product Development. At
Cortech, Dr. Rodell was responsible for all phases of drug development including
regulatory affairs and clinical trials.

Dr. Rodell received his M.D. and A.B. degrees from the University of North
Carolina, at Chapel Hill. He subsequently completed post-doctoral training at
the Eleanor Roosevelt Institute for Cancer Research and the Webb-Waring Lung
Institute in Denver, Colorado. Dr. Rodell is Board Certified in Internal
Medicine and Pulmonary Medicine and is a Fellow of the American College of Chest
Physicians.

BOARD AND COMMITTEE MEETINGS

The Board of Directors has a Compensation Committee, whose function is to
administer the Company's 1994 Stock Incentive Plan and other compensation plans
and to act upon such other compensation matters as may be referred to it by the
Board. The members of the Committee during 1998 were Messrs. Biro, Lang, and
Sitaraman. The Compensation Committee met four times during 1998.

The Board has an Audit Committee, which oversees the Company's internal
accounting procedures and consults with, and reviews the reports of, the
Company's independent accountants. The members of the Committee during 1998 were
Messrs. Biro, Lang and Sitaraman. The Audit Committee met five times during
1998.

During the year ended December 31, 1998, the Board of Directors of the Company
met ten times, and each director, except Dr. Barker, attended at least 75% of
the Company's Board meetings held during the period for which he or she was a
director. Dr. Barker attended three of the eight meetings held during the period
for which she was a director. The Board does not have a separate nominating
committee.

COMPENSATION OF DIRECTORS AND EXECUTIVE OFFICERS

Directors

The Company pays an annual fee of $4,000 to each non-employee director and an
additional $1,000 to non-employee directors for serving as committee chairmen,
but does not pay meeting fees. Directors are also reimbursed for their expenses
incurred in attending meetings. Employee directors receive no compensation as
directors. Compensation is also paid for special assignments.

Under the Company's 1994 Stock Incentive Plan non-employee directors are awarded
options to purchase 3,000 shares of Common Stock upon becoming directors of the
Company and options to purchase 1,000 shares of Common Stock annually
thereafter.

Executive Officers

Summary Compensation Table
- --------------------------

The following table shows the compensation paid during the last three years to
Company officers who received more than $100,000, or served as Chief Executive
Officer:

                                       8
<PAGE>

<TABLE>
<CAPTION>
                                                                                                   Long Term
                                                                                                  Compensation
                                                                        Annual Compensation          Awards
                                                                        -------------------          ------
Name and Position                                      Year             Salary        Bonus          Options
<S>                                                    <C>            <C>           <C>           <C>
Ray R. Rogers,
  Chairman of the Board /7/                            1998           $  210,200    $50,000/2/      28,000/1/
                         -                                                                  -              -
                                                       1997           $  185,000    $37,000/4/      20,000/3/
                                                                                            -              -
                                                       1996           $  185,000         --         12,400/5/

Dr. Anna D. Barker,
  President and Chief Executive Officer /7/            1998           $   61,100         --             --
                                         -             1997           $  185,000    $27,750/4/      20,000/3/
                                                                                            -              -
                                                       1996           $  185,000         --         12,400/5/
                                                                                                           -

Dr. Timothy C. Rodell,
President, OXIS Therapeutics, Inc.                     1998           $  224,600    $50,000/2/      20,000/1/
                                                                                            -              -
  (from March 1, 1996)                                 1997           $  220,000    $15,000/4/      10,000/3/
                                                                                            -              -
                                                       1996           $  183,300         --         65,000/6/
                                                                                                           -

Humberto V. Reyes
President, OXIS Health Products, Inc.                  1998           $  150,100    $35,000/2/      15,000/1/
                                                                                            -              -
  (from August 1, 1997)

Jon S. Pitcher,
  Vice President, Chief Financial Officer              1998           $  124,200    $25,000/2/      15,000/1/
                                                                                            -              -
  and Secretary                                        1997           $  110,400    $14,000/4/      10,000/3/
                                                                                            -              -
                                                       1996           $  105,000         --          7,000/5/
                                                                                                           -
</TABLE>

/1/  Options to purchase 28,000 shares of Common Stock awarded to Mr. Rogers,
     options to purchase 20,000 shares of Common Stock awarded to Dr. Rodell and
     options to purchase 15,000 shares of Common Stock awarded to Messrs. Reyes
     and Pitcher as part of their 1998 compensation.

/2/  Bonuses for 1998 approved by the Compensation Committee.
 -

/3/  Options to purchase 20,000 shares of Common Stock each awarded to Mr.
 -
     Rogers and Dr. Barker and options to purchase 10,000 shares of Common Stock
     each awarded to Dr. Rodell and Mr. Pitcher as part of their 1997
     compensation.

/4/  Bonuses for 1997 approved by the Compensation Committee.
 -

/5/  Options to purchase 12,400 shares of Common Stock each awarded to Mr.
 -
     Rogers and Dr. Barker and options to purchase 7,000 shares of Common Stock
     awarded to Mr. Pitcher as part of their 1996 compensation.

/6/  Options to purchase 60,000 shares of Common Stock awarded to Dr. Rodell as
 -
     part of his initial employment agreement and options to purchase an
     additional 5,000 shares of Common Stock awarded as part of his 1996
     compensation.

7/  Effective March 18, 1998, Dr. Barker resigned as the Company's President
- -
    and Chief Executive Officer and Mr. Rogers was appointed Chief Executive
    Officer.

In connection with Dr. Barker's resignation as the Company's President and Chief
Executive Officer, the Company and Dr. Barker entered into a consulting
agreement pursuant to which the Company agreed to pay to Dr. Barker $15,417 per
month for a nine-month period. Pursuant to the agreement, Dr. Barker has become
fully vested with respect to all stock options issued to her by the Company, and
her right to exercise such options has been extended until a date two years and
nine months following her resignation.

                       OPTION GRANTS IN LAST FISCAL YEAR

Options granted to executive officers of the Company who are included in the
Summary Compensation Table above for 1998 were as shown below:

                                       9
<PAGE>

<TABLE>
<CAPTION>
                                            Individual Grants
  -------------------------------------------------------------------------------------------
                             Number of         % of total
                           common shares     options granted       Exercise
                            underlying        to employees        price per      Expiration
  Name                        grant             in 1998             share           date
  ----                        -----             -------             -----           ----
  <S>                      <C>               <C>                  <C>           <C>
  Ray R. Rogers            28,000/1/              30%             $   3.44      July 12, 2008
                                  -
  Timothy C. Rodell        20,000/1/              21%             $   3.44      July 12, 2008
                                  -
  Humberto V. Reyes        15,000/1/              16%             $   3.44      July 12, 2008
                                  -
  Jon S. Pitcher           15,000/1/              16%             $   3.44      July 12, 2008
                                  -
</TABLE>


/1/  The options granted to the executive officers during 1998 become
 -
  exercisable as to 1/3 of the shares in each of 1998, 1999 and 2000.

FISCAL YEAR END OPTION VALUES

During 1998, no options were exercised by any of the Company's executive
officers. All options issued to executive officers who are included in the
Summary Compensation Table above are shown below.

<TABLE>
<CAPTION>
                                 Number of
                               common shares               Value of
                                underlying                unexercised
                                unexercised               in-the-money
                                 options at                options at
                                December 31,              December 31,
Name                                1998                      1998
- ----                   ----------------------------  --------------------------
                        Exercisable   Unexercisable  Exercisable  Unexercisable
                       -------------  -------------  -----------  -------------
  <S>                  <C>            <C>            <C>          <C>
  Ray R. Rogers               52,066         25,334       $2,916         $1,458
  Anna D. Barker              49,400              0       $4,375         $    0
  Timothy C. Rodell           58,334         36,666       $1,458         $  729
  Humberto V. Reyes           31,666         23,334       $5,833         $2,916
  Jon S. Pitcher              30,667         13,333       $1,458         $  729
</TABLE>

            SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

To the Company's knowledge, the following persons (directors and/or executive
officers of the Company) failed to file on a timely basis reports required by
Section 16(a) of the Securities Exchange Act of 1934, as amended, for
transactions or events occurring in the preceding fiscal year ended December 31,
1998:

                         Number    Transactions not    Form not
Name                   of reports  timely reported   timely filed
- ----                   ----------  ----------------  ------------

  James D. McCamant             1                 1  Form 5

The above form has now been filed. The transaction in Company securities as to
which a late filing was made as listed consisted of the grant of options
pursuant to the Company's 1994 Stock Incentive Plan. None of such options have
been exercised.

                                       10
<PAGE>

     PROPOSAL NO. 2 -- APPROVAL OF AMENDMENT TO 1994 STOCK INCENTIVE PLAN
                            (Item 2 on Proxy Card)

The Company's Board of Directors and stockholders have previously approved the
adoption of the Company's 1994 Stock Incentive Plan (the "Plan") and the
reservation of 840,000 shares of the Company's Common Stock for issuance
thereunder. In March 1999, the Board of Directors authorized an amendment to the
Plan, subject to stockholder approval, to increase the shares reserved for
issuance thereunder by 525,000 shares, bringing the total number of shares
issuable under the Plan to 1,365,000. At the Meeting, the stockholders are
requested to consider and approve the proposed amendment to the Plan to increase
the number of shares issuable under the Plan to 1,365,000. The OXIS Board
believes that adoption of the amendment to the Plan will ensure OXIS' ability to
attract and retain the best available individuals to serve as employees,
officers, directors, consultants, independent contractors and advisors of OXIS.

Summary of the Plan

The Plan permits granting stock options to acquire shares of OXIS' Common Stock
("Options"), awarding stock bonuses of OXIS' Common Stock, selling shares of
OXIS' Common Stock and granting stock appreciation rights ("SARs")
(collectively, the "Awards").  Both incentive stock options ("ISOs") within the
meaning of section 422 of the Internal Revenue Code of 1986, as amended (the
"Code"), and nonqualified stock options ("NQSOs") may be granted under the Plan.

Awards under the Plan to other than directors of OXIS who are not employees of
either OXIS or a subsidiary of OXIS (the "Non-employee Directors") are not
determinable because such awards are made in the discretion of the OXIS Board or
its designated committee.  See "Administration" below.

Purpose

The purposes of the Plan are to attract, retain and provide equity incentive to
selected persons to promote the financial success of OXIS.  The OXIS Board of
Directors believes that it is essential to the future of OXIS that OXIS be in a
position to grant Awards under a stock incentive plan to selected employees,
officers, directors, consultants, independent contractors and advisors in order
for OXIS to remain competitive in attracting and retaining such individuals.

Administration

The Plan is administered by a committee of the Board of Directors of OXIS (the
"Plan Committee") comprised of at least two "disinterested persons" within the
meaning of former Rule 16b-3(c)(2) of the Securities Exchange Act of 1934, as
amended (the "Exchange Act"), although the Plan could be administered by the
OXIS Board if it were comprised solely of "disinterested persons". The
interpretation and construction of any provision of the Plan or any related
agreement by the Plan Committee is final and binding. With the exception
discussed below in "Options - Non-Employee Director Formula Option Grants", the
Plan Committee selects the persons to whom Awards will be granted, determines
the type of Award, the number of shares to be covered by any Options or SARs
awarded, the exercise price of any such Options, the period during which any
such Options may be exercised and all other terms and conditions of Awards.

Eligibility

With the exception discussed below in "Options - Non-Employee Director Formula
Option Grants", the Plan provides that awards may be granted to employees,
officers, directors, consultants, independent contractors and advisors of OXIS
or any parent, subsidiary or affiliate of OXIS. ISOs may be granted only to
employees (including officers and directors who are also employees) of OXIS or
any parent, subsidiary or affiliate of OXIS. See "Certain United States Federal
Income Tax Information" below for information concerning the tax treatment of
ISOs and NQSOs.

                                       11
<PAGE>

As of October 8, 1999, there are six directors of OXIS (five of whom are Non-
Employee Directors) and three OXIS officers (who are not directors) eligible to
participate in the Plan. There are approximately 50 employees of OXIS and its
subsidiaries who are not serving as officers who are also eligible to
participate. It is not possible to estimate the number of consultants,
independent contractors and advisors who are or may become eligible to
participate in the Plan.

Options

Grant of Options
- ----------------

The date of grant of an Option is the date on which the Plan Committee makes the
determination to grant the Option unless otherwise specified by the Plan
Committee. Option grants are evidenced by a written stock option grant and, if
for any reason a written stock option grant is not executed within sixty (60)
days of the date of grant, such Option grant shall be null and void. No
consideration shall be received by OXIS for the granting of Options. Subject to
the express provisions of the Plan, the exercise of an Option shall be subject
to such terms, conditions and restrictions as the Plan Committee may impose in
its sole discretion, including restrictions concerning transferability,
repurchase and forfeiture.

Options shall be exercisable on the terms set forth in the stock option grant;
provided that no Option shall be exercisable after the expiration of ten years
from the Option grant date. The Plan Committee may accelerate the earliest
exercise date of any Option.

The Plan states that there is a $100,000 limit to the aggregate fair market
value (calculated as set forth in "Option Price" below) of stock with respect to
which ISOs, whether granted under the Plan or any other ISO plan of OXIS or its
parent or subsidiary, are exercisable for the first time by an optionee during
any calendar year. The above limitations are driven by provisions of the Code
and are subject to change in the event that the relevant sections of the Code or
regulations promulgated thereunder are amended.

Option Price
- ------------

The exercise price of a NQSO shall be not less than eighty-five percent (85%) of
the fair market value of the shares underlying the Option on the date the Option
is granted. The exercise price of an ISO shall be no less than one hundred
percent (100%) of the fair market value of the shares on the date the Option is
granted, unless the person to whom the Option is granted is a ten percent (10%)
shareholder of OXIS in which case the exercise price shall be not less than one
hundred ten percent (110%) of the fair market value of the shares on the date
the Option is granted. The Plan Committee shall have the power, within certain
limitations, to reduce the exercise price of outstanding Options.

For purposes of the Plan, the fair market value of a share of OXIS' Common Stock
on a given date shall be the closing price on the NASDAQ National Market System
on the last trading day prior to the date of determination. The closing price
per share of OXIS' Common Stock on October 8, 1999, on the NASDAQ National
Market System was 13/16.

The method of payment for shares issued upon exercise of Options granted under
the Plan shall be determined by the Plan Committee and may consist of cash,
cancellation of indebtedness, other shares of Common Stock and certain other
methods permitted by law.

Non-Employee Director Formula Option Grants
- -------------------------------------------

No ISOs, SARs or stock bonuses shall be awarded or shares sold to Non-Employee
Directors under the Plan.  All grants of Options to Non-Employee Directors are
automatic and nondiscretionary.  Accordingly, no person shall have any
discretion to select which such Non-Employee Directors shall be granted Options,
to determine when

                                       12
<PAGE>

such Options may be granted or to determine the number of shares of OXIS' Common
Stock to be covered by Options granted to such Non-Employee Directors. All
grants of Options to such Non-Employee Directors shall be made in strict
accordance with the following provisions:

(i)  On the first business day following OXIS Board approval of the Plan, each
Non-Employee Director received a NQSO covering 3,000 shares. The OXIS Board
approved the Plan on June 15, 1994 and the closing price per share of OXIS'
Common Stock was $17.50. Non-Employee Directors appointed by the OXIS Board or
elected by the OXIS stockholders after such date shall receive a NQSO covering
3,000 shares on the first business day following such appointment or initial
election. Thereafter, annually on the first business day following the 1995
Annual Meeting of OXIS' stockholders and the first business day following each
Annual Meeting thereafter, each Non-Employee Director (other than one taking
office for the first time as a result of his or her election at such Meeting and
therefore receiving a NQSO covering 3,000 shares) shall receive a NQSO covering
1,000 shares.

(ii) The exercise price of such Options shall be equal to one hundred percent
(100%) of the fair market value of the shares on the date of grant determined as
set forth under "Option Price" above.

(iii) Such Options shall be exercisable beginning six months after the date of
the grant and their term shall be ten years.

Stock Bonuses

The Plan Committee may award shares under the Plan as stock bonuses for no
consideration or for such minimum consideration as may be required by applicable
law in an amount and form as determined by the Plan Committee.  An award of a
stock bonus shall be subject to such terms, conditions and restrictions as the
Plan Committee may impose in its sole discretion, including restrictions
concerning transferability, repurchase and forfeiture.  The recipient of a stock
bonus must also satisfy any applicable federal, state or local tax withholding
requirements.

Stock Sales

The Plan Committee may issue shares of OXIS Common Stock under the Plan for such
amount (no less than par value) and form of consideration as determined by the
Plan Committee.  A stock sale under the Plan shall be subject to such terms,
conditions and restrictions as the Plan Committee may impose in its sole
discretion, including restrictions concerning transferability, repurchase or
forfeiture.  The purchaser must also satisfy any applicable federal, state or
local tax withholding requirements.

Stock Appreciation Rights

A SAR may be granted by the Plan Committee in tandem with an Option or as a
freestanding SAR. No consideration shall be received by OXIS for the granting of
SARs. Subject to the express provisions of the Plan, the exercise of a SAR shall
be subject to such terms, conditions and restrictions as the Plan Committee may
impose at its sole discretion, including restrictions concerning
transferability, repurchase and forfeiture. The recipient of a SAR must also
satisfy any applicable federal, state or local tax withholding requirements.

A SAR shall be exercisable only at the time or times established by the Plan
Committee; provided that no SAR shall be exercisable after the expiration of ten
years from the date the SAR was granted. If a SAR is granted in connection with
an Option, the SAR shall be exercisable only to the extent and on the same
conditions that the related Option could be exercised and, upon exercise of such
a SAR, any Option or any portion of such Option to which the SAR relates shall
terminate. Similarly, upon the exercise of an Option to which a SAR relates, the
SAR or portion thereof to which the Option relates shall terminate.

The Plan Committee may accelerate the earliest exercise date of any SAR.

                                       13
<PAGE>

Nonassignability of Options and SARs

Options and SARs granted pursuant to the Plan are nonassignable and
nontransferable by the optionee or recipient, other than by will or by the laws
of descent and distribution and may be exercised, during the lifetime of the
optionee or recipient, only by the optionee or recipient or any permitted
transferee.

Adjustment Upon Changes in Capitalization and Corporate Transactions

In the event that the number of outstanding shares of Common Stock of OXIS is
increased or decreased by a change in the capital structure of OXIS without
consideration, such as stock splits or dividends, or, if a substantial portion
of the assets of OXIS are distributed without consideration to the stockholders
of OXIS in a spin-off or similar transaction, appropriate adjustments shall be
made in the number or kind of shares available for Awards under the Plan, the
number or kind of shares subject to outstanding Options or SARs and the exercise
price per share of such Options.

In the event of a merger, consolidation, or similar occurrence where OXIS is not
the surviving corporation, or the sale of all or substantially all of the assets
of OXIS, each outstanding Award shall be assumed or substituted by such
successor corporation.  In the event such successor corporation does not agree
to assume or substitute such Awards or to provide substantially similar
consideration to optionees or other recipients of Awards as was provided to
stockholders, or in the event of a dissolution or liquidation of OXIS, OXIS
shall notify each optionee or other recipient that the Awards shall expire on a
date at least twenty (20) days after OXIS gives such written notice.

Termination of Employment or Service Through Death, Disability or Otherwise

Under the Plan, in the event an optionee ceases to be employed by or to provide
services to OXIS or any parent or subsidiary of OXIS (and, in the case of a
NQSO, by or to any affiliate of OXIS) for any reason other than death or
permanent and total disability, any Option which was exercisable at the date of
termination may thereafter be exercised for a period of thirty (30) days.  If
termination results from death or permanent and total disability, any Option
which was exercisable at the date of termination may thereafter be exercised for
a period of twelve (12) months.  However, in no event may any Option be
exercised once its term has expired.

Plan Amendment and Termination

Except as described below, the Plan Committee may amend the Plan at any time or
may terminate the Plan without stockholder approval. However, except with
respect to SARs which may be withdrawn or amended at any time or may become
subject to retroactive rules and regulations, no action may be taken which would
impair the rights of any recipient of an Award without the consent of such
recipient. In any event, the Plan will terminate on April 30, 2004.

Stockholder approval is required for certain specified amendments to the Plan,
including any amendment that increases the total number of shares for which
Awards may be granted, extends the duration of the Plan, extends the period
during and over which Options or SARs may be exercised under the Plan, or
changes the class of persons eligible to receive awards granted under the Plan
(except as may be required to comport with changes in the Code, ERISA or
regulations promulgated thereunder).

Certain United States Federal Income Tax Information Regarding Options

Options granted under the Plan may be either ISOs, as defined in Section 422 of
the Code, or NQSOs.

                                       14
<PAGE>

Incentive Stock Options
- -----------------------

If an Option granted under the Plan is an incentive stock option, the optionee
will recognize no income under the grant of the incentive stock option and incur
no tax liability at the time of exercise unless the optionee is subject to the
alternative minimum tax. OXIS will not be allowed a deduction for federal income
tax purposes as a result of the exercise of the incentive stock option
regardless of the applicability of the alternative minimum tax. Upon the sale or
exchange of the shares at least two years after the grant of the option and one
year after receipt of the shares by the optionee, any gain will be treated as
long-term capital gain. If these holding periods are not satisfied, the optionee
will recognize ordinary income equal to the difference between the exercise
price and the lower of the fair market value of the stock at the date of option
exercise or the sale price of the stock. OXIS will be entitled to a deduction in
the same amount as the ordinary income recognized by the optionee.

Nonqualified Stock Options
- --------------------------

All Options which do not qualify as incentive stock options under the Code are
referred to as nonqualifed stock options. Generally, an optionee will not
recognize any taxable income at the time the optionee is granted a nonqualified
stock option. However, upon exercise of the Option, the optionee will recognize
ordinary income for income tax purposes equal to the excess of the then fair
market value of the shares over the option price. The income recognized by an
optionee who is also an employee of OXIS will be subject to tax withholdings by
OXIS by payment in cash or out of the current earnings paid to the optionee.
OXIS will be allowed a deduction for federal tax purposes in an amount equal to
the income recognized by the optionee so long as OXIS has met all applicable
withholding requirements and so long as the exercise of the option by optionee
does not cause OXIS to violate the limits on executive compensation set forth in
Section 162(m) of the Code. If the optionee holds such shares for more than one
year following exercise of the option, any gain realized upon disposition will
be treated as long-term capital gain. If the shares are sold within one year
after the exercise date, any gain realized upon disposition will be treated as
short-term capital gain. The gain realized upon disposition will be the excess,
if any, of the sales price over the tax basis of the shares.

Tax Summary Only
- ----------------

The foregoing summary of the effect of federal income taxation upon the optionee
and OXIS with respect to the purchase of OXIS' shares under the Plan does not
purport to be complete, and reference should be made to the applicable
provisions of the Code. In addition, the summary does not discuss the provisions
of the income tax laws of any municipality, state, or foreign country.

Options Received by Certain Persons

Options granted under the 1994 Stock Incentive Plan to certain individuals and
groups of individuals since the inception of the Plan are set forth below:

                                       15
<PAGE>

<TABLE>
<CAPTION>

                                                                    Number of
                                                                  Common Shares
                                                                Underlying Grant
                                                                ----------------
  <S>                                                                 <C>
  Executive officers included in Summary Compensation Table:
     Ray R. Rogers, Chairman and Chief Executive Officer              77,400
     Timothy C. Rodell, President, OXIS Therapeutics, Inc.            95,000
     Humberto V. Reyes, President, OXIS Health Products, Inc.         55,000
     Jon S. Pitcher, Vice President, Chief Financial Officer
         and Secretary                                                44,000

  Nominees for election as directors, other than Rogers, above:
     Timothy G. Biro                                                   7,000
     Richard A. Davis                                                  4,000
     Brenda D. Gavin                                                   4,000
     Stuart S. Lang                                                    6,000
     A.R. Sitaraman                                                    7,000

  All current executive officers, as a group                         271,400

  All current directors who are not executive officers,
     as a group                                                       28,000

  All employees, excluding executive officers, as a group             73,900
</TABLE>

Stockholder Rights

The recipient of an Award shall have no rights as a stockholder of OXIS with
respect to any shares until the date such recipient is issued a stock
certificate for such shares of OXIS.

Vote Required

The approval of the amendment of OXIS' 1994 Stock Incentive Plan requires the
affirmative vote of the holders of a majority of the shares of Voting Stock
present in person or represented by Proxy.  Consequently, abstentions will have
the effect of a vote against the proposed amendment.

THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE "FOR" APPROVAL OF THE
AMENDMENT TO OXIS' 1994 STOCK INCENTIVE PLAN AND THE RESERVATION OF AN
ADDITIONAL 525,000 SHARES FOR ISSUANCE THEREUNDER. UNLESS OTHERWISE DIRECTED BY
A STOCKHOLDER, PROXIES WILL BE VOTED "FOR" ADOPTION OF THIS AMENDMENT OF THE
1994 STOCK INCENTIVE PLAN AND RESERVATION OF AN ADDITIONAL 525,000 SHARES FOR
ISSUANCE THEREUNDER.

                       SELECTION OF INDEPENDENT AUDITORS

Deloitte & Touche LLP has been selected to act as the Company's principal
accountant for the fiscal year ending December 31, 1999. Representatives of
Deloitte & Touche are expected to be present at the Meeting with the opportunity
to make a statement if they desire to do so and to respond to questions of
stockholders.

                                       16
<PAGE>

                                 OTHER MATTERS

The Board of Directors of the Company knows of no other matters which are to be
brought before the Meeting. If any other matters should be presented for proper
action, it is the intention of the persons named in the Proxy to vote in
accordance with their discretion pursuant to the terms of the Proxy.

It is important the Proxies be returned promptly. Therefore, stockholders who do
not expect to attend the meeting in person are urged to fill in, sign, date and
return the enclosed Proxy.

Copies of the Company's Annual Report on Form 10-K and an amendment thereto on
Form 10-K/A for the fiscal year ended December 31, 1998, filed with the
Securities and Exchange Commission, have been or are being delivered
simultaneously herewith to each stockholder of the Company of record as of
October 8, 1999, and are incorporated by reference herein.

The Company's stock transfer agent and registrar is Boston EquiServe, P.O. Box
644, Boston, MA 02102. Telephone: (800) 442-2001.

                                    OXIS INTERNATIONAL, INC.

                                    By Ray R. Rogers
                                    Chairman and Chief Executive Officer

                                       17
<PAGE>

                           OXIS INTERNATIONAL, INC.

          PROXY SOLICITED BY AND ON BEHALF OF THE BOARD OF DIRECTORS

     The undersigned hereby appoints Ray R. Rogers, Stuart S. Lang and each of
them, as Proxies, each with the power to appoint his or her substitute, to
represent and to vote, as designated on the reverse side, all the shares of
Common Stock and voting Preferred Stock of OXIS International, Inc., held of
record by, or otherwise entitled to be voted by, the undersigned on October 8,
1999 at the 1999 Annual Meeting of Stockholders of OXIS International, Inc., to
be held on December 2, 1999 and any adjournment or postponement thereof.



                  CONTINUED AND TO BE SIGNED ON REVERSE SIDE

                              -------------------
                                SEE REVERSE SIDE
                              -------------------
<PAGE>

This proxy, when properly executed, will be voted in the manner directed herein
by the undersigned stockholder. If no directions are indicated, the Proxies will
vote FOR Proposals 1 and 2.

1.  ELECTION OF DIRECTORS
Nominees: Timothy G. Biro; Richard A. Davis; Brenda D. Gavin; Stuart S. Lang,
Ray R. Rogers; A.R. Sitaraman

For _______       Withheld ______  For all nominees except as noted ____________

2.  To approve an amendment of the Company's 1994 Stock Incentive Plan to
increase the number of shares of common stock available for issuance thereunder
by 525,000 shares, to an aggregate of 1,365,000 shares.

For _______       Against _______  Abstain ____________

3.  OTHER MATTERS
    The Proxies are authorized to vote in their discretion, upon such other
matters as may properly come before the meeting, and any adjournment or
postponement thereof.

- --------------------------------------------------------------------------------
  PLEASE MARK, DATE, SIGN AND MAIL THIS PROXY PROMPTLY IN THE RETURN ENVELOPE
                                              --------
                                   ENCLOSED.
- --------------------------------------------------------------------------------

If stock is held jointly, signature should include both names. If stock is held
by executors, administrators, trustees, guardians and others signing in a
representative capacity, please give full title. If stock is held by a
corporation, please sign in full corporate name and give name and title of
authorized officer. If stock is held by a partnership, please sign in
partnership name by authorized person.

                         Signature: ______________________  Date: ___________

                         Signature: ______________________  Date: ___________


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