OXIS INTERNATIONAL INC
10-Q, 2000-08-14
PHARMACEUTICAL PREPARATIONS
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<PAGE>

                      SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, DC 20549

                                   FORM 10-Q


 X  Quarterly report pursuant to Section 13 or 15(d) of the Securities Exchange
---
    Act of 1934 for the quarterly period ended June 30, 2000.

                                      or

___ Transition report pursuant to Section 13 or 15(d) of the Securities Exchange
Act of 1934 for the transition period from ___ to _______.



                         Commission File Number O-8092



                           OXIS INTERNATIONAL, INC.

            (Exact name of registrant as specified in its charter)

                 Delaware                               94-1620407
---------------------------------------        ------------------------------
     (State or other jurisdiction of                 (I.R.S. Employer
      incorporation or organization)               Identification No.)

      6040 N. Cutter Circle, Suite 317, Portland, Oregon           97217
-----------------------------------------------------------------------------
      (Address of principal executive offices)                  (Zip Code)

                                (503) 283-3911
    ----------------------------------------------------------------------------
             (Registrant's telephone number, including area code)



Indicate by check mark whether the Registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the preceding 12 months (or for such shorter period that the Registrant was
required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days.
                                YES  X  NO ___
                                    ---


At June 30, 2000, the issuer had outstanding the indicated number of shares of
                            common stock: 9,370,677
<PAGE>

                        PART I.  FINANCIAL INFORMATION

Item 1.   Financial Statements.

<TABLE>
<CAPTION>
                       Consolidated Statements of Operations (Unaudited)

                                              Three Months Ended           Six Months Ended
                                                   June 30                     June 30
                                          -------------------------   -------------------------
                                              2000          1999          2000          1999
<S>                                       <C>           <C>           <C>           <C>
Revenues                                  $   779,000   $ 2,701,000   $ 1,722,000   $ 4,157,000

Costs and expenses:
  Cost of product sales                       833,000     1,406,000     1,685,000     2,413,000
  Cost of technology sold                          --     1,279,000            --     1,279,000
  Research and development                    447,000       952,000       785,000     1,722,000
  Selling, general and administrative         642,000       830,000     1,364,000     1,688,000
                                          -----------   -----------   -----------   -----------
     Total costs and expenses               1,922,000     4,467,000     3,834,000     7,102,000
                                          -----------   -----------   -----------   -----------
Operating loss                             (1,143,000)   (1,766,000)   (2,112,000)   (2,945,000)
Interest income                                65,000         7,000        87,000        25,000
Interest expense                              (23,000)      (23,000)      (44,000)      (53,000)
                                          -----------   -----------   -----------   -----------
Net loss                                   (1,101,000)   (1,782,000)   (2,069,000)   (2,973,000)
Other comprehensive income
  (loss) - foreign currency
  translation adjustments                       6,000       (43,000)      (20,000)      (31,000)
                                          -----------   -----------   -----------   -----------
Comprehensive loss                        $(1,095,000)  $(1,825,000)  $(2,089,000)  $(3,004,000)
                                          ===========   ===========   ===========   ===========

Net loss per share - basic and diluted    $      (.12)  $      (.23)  $      (.24)  $      (.38)
                                          ===========   ===========   ===========   ===========

Weighted average number of
 shares used in computation -
 basic and diluted                          9,324,735     7,871,196     8,794,943     7,858,631
                                          ===========   ===========   ===========   ===========
</TABLE>

                                       2
<PAGE>

                          CONSOLIDATED BALANCE SHEETS
                                  (Unaudited)


                                      June 30,    December 31,
                                        2000          1999
ASSETS

Current assets:
  Cash and cash equivalents          $4,564,000    $  789,000
  Accounts receivable                   665,000     1,072,000
  Inventories                         1,245,000     1,327,000
  Prepaid and other                      81,000        37,000
                                     ----------    ----------

     Total current assets             6,555,000     3,225,000

Furniture and equipment, net            689,000       808,000

Technology for developed products       773,000       864,000

Other assets                            321,000       287,000
                                     ----------    ----------

     Total assets                    $8,338,000    $5,184,000
                                     ==========    ==========

                                       3
<PAGE>

                          CONSOLIDATED BALANCE SHEETS
                                  (Unaudited)

<TABLE>
<CAPTION>
                                                            June 30,     December 31,
                                                              2000           1999
<S>                                                       <C>            <C>
LIABILITIES AND SHAREHOLDERS' EQUITY

Current liabilities:
  Notes payable                                           $    446,000   $    681,000
  Accounts payable                                             479,000      1,131,000
  Accrued payroll, payroll taxes and other                     482,000        395,000
  Current portion of long-term debt                             95,000         94,000
                                                          ------------   ------------
     Total current liabilities                               1,502,000      2,301,000

Long-term debt due after one year                              168,000        194,000

Shareholders' equity:
  Preferred stock - $.01 par value; 15,000,000 shares
   authorized:
     Series B - 428,389 shares issued and outstanding
     at June 30, 2000  (liquidation preference of
     $1,000,000)                                                 4,000          4,000
     Series C - 608,536 shares issued and outstanding
     at June 30, 2000                                            6,000          6,000
  Common stock - $.001 par value; 95,000,000 shares
   authorized; 9,370,677 shares issued and outstanding
   at June 30, 2000 (7,928,784 at December 31, 1999)             9,000          8,000
  Additional paid in capital                                58,823,000     52,756,000
  Accumulated deficit                                      (51,819,000)   (49,750,000)
  Accumulated other comprehensive loss -
     foreign currency translation adjustment                  (355,000)      (335,000)
                                                          ------------   ------------

     Total shareholders' equity                              6,668,000      2,689,000
                                                          ------------   ------------

Total liabilities and shareholders' equity                $  8,338,000   $  5,184,000
                                                          ============   ============
</TABLE>

                                       4
<PAGE>

                     CONSOLIDATED STATEMENTS OF CASH FLOWS
                                  (Unaudited)

<TABLE>
<CAPTION>
                                                                  Six Months Ended
                                                                      June 30,
                                                             -------------------------
                                                                 2000          1999
<S>                                                          <C>           <C>
Cash flows from operating activities:
 Net loss                                                    $(2,069,000)  $(2,973,000)
 Adjustments to reconcile net loss to cash
  used for operating activities:
  Depreciation and amortization                                  276,000       550,000
  Gain on sale of land and building                                   --       (16,000)
  Loss on sale of technology                                          --       368,000
  Cash proceeds from sale of technology                               --       342,000
  Changes in assets and liabilities:
   Accounts receivable                                           405,000        80,000
   Inventories                                                    82,000       124,000
   Other current assets                                          (45,000)      163,000
   Accounts payable                                             (651,000)     (111,000)
   Customer deposits                                                  --      (120,000)
   Accrued payroll, payroll taxes and other                      119,000      (127,000)
                                                             -----------   -----------

     Net cash used for operating activities                   (1,883,000)   (1,720,000)

Cash flows from investing activities:
 Proceeds from sale of land and building                              --     1,959,000
 Purchases of equipment                                          (55,000)     (142,000)
 Additions to other assets                                       (65,000)      (59,000)
 Other, net                                                        5,000        (4,000)
                                                             -----------   -----------

     Net cash provided by (used for) investing activities       (115,000)    1,754,000

Cash flows from financing activities:
 Proceeds from issuance of stock, net of related costs         5,868,000            --
 Repayment of short-term borrowings                              (75,000)           --
 Repayment of long-term debt                                     (26,000)   (1,517,000)
                                                             -----------   -----------

     Net cash provided by (used for) financing activities      5,767,000    (1,517,000)

Effect of exchange rate changes on cash                            6,000        17,000
                                                             -----------   -----------

Net increase (decrease) in cash and cash equivalents           3,775,000    (1,466,000)

Cash and cash equivalents - beginning of period                  789,000     2,575,000
                                                             -----------   -----------

Cash and cash equivalents - end of period                    $ 4,564,000   $ 1,109,000
                                                             ===========   ===========

Non-cash transactions:
  Issuance of common stock in exchange
     for cancellation of notes and accrued interest          $   202,000   $        --
  Note received as part of proceeds from sale
     of technology                                                    --       569,000
</TABLE>

                                       5
<PAGE>

             CONDENSED NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

1. FINANCIAL STATEMENTS AND CONDENSED NOTES

   The unaudited consolidated financial statements, which have been prepared in
   accordance with the instructions to Form 10-Q, do not include all of the
   information and notes required by accounting principles generally accepted in
   the United States of America for complete financial statements. All
   adjustments considered necessary by management for a fair presentation have
   been included. Operating results for interim periods are not necessarily
   indicative of the results that may be expected for the full year.

   An annual report (Form 10-K) has been filed with the Securities and Exchange
   Commission ("Commission") for the year ended December 31, 1999. That report
   contains, among other information, a description of the Company's business,
   audited financial statements, notes to the financial statements, the report
   of the independent auditors and management's discussion and analysis of
   results of operations and financial condition. Readers of this report are
   presumed to be familiar with that annual report.


2. INVENTORIES

   Inventories are stated at the lower of cost or market. Cost has been
   determined by using the first-in, first-out method. Inventories at June 30,
   2000 and December 31, 1999, consisted of the following:

                              June 30,    December 31,
                                2000          1999

          Raw materials      $  682,000    $  492,000
          Work in process       364,000       438,000
          Finished goods        199,000       397,000
                             ----------    ----------

          Total              $1,245,000    $1,327,000
                             ==========    ==========

3. SHAREHOLDERS' EQUITY

   In April 2000 the Company completed a private placement of units, consisting
   of one share of the Company's common stock plus warrants to purchase two
   shares of the Company's common stock (the "Units"), primarily to a series of
   institutional investors. The Units were priced at the Nasdaq closing price
   for the Company's common stock the day prior to the signing of the
   subscription agreements relating to the purchase of such Units. The price per
   Unit ranged from $3.94 to $4.75. A total of 1,376,950 common shares and
   warrants to purchase 2,753,000 common shares were issued in exchange for
   gross proceeds of $6,050,000 in cash and conversion of $202,000 of short-term
   notes and accrued interest payable. The exercise price of one-half of the
   warrants issued in the private placement is

                                       6
<PAGE>

   equal to 125% of the price paid per Unit. The exercise price of the other
   half of the warrants is equal to 150% of the price paid per Unit.

   The Company has agreed to issue additional warrants to its placement agents
   giving the agents the right to acquire 155,000 common shares at an exercise
   price of $5.94 per share.

   The Company has filed a preliminary registration statement with the
   Commission registering the common shares, and the common shares issuable upon
   exercise of the warrants, issued in the private placement.


4. STOCK OPTIONS

   The Company has a stock incentive plan under which 1,365,000 shares of the
   Company's common stock are reserved for issuance (the "Plan"). The Plan
   permits the Company to grant stock options to acquire shares of the Company's
   common stock, award stock bonuses of the Company's common stock, and grant
   stock appreciation rights. During the six months ended June 30, 2000, options
   to purchase 225,000 shares at an exercise price of $1.9125 have been issued
   under the Plan. Options to purchase an additional 400,000 common shares at an
   exercise price of $1.9125 have also been issued, subject to shareholder
   approval of an amendment to the Plan.

   The Company's board of directors has also approved an additional option grant
   to purchase 400,000 common shares at an exercise price of $1.5625. This
   option grant is not issued pursuant to the Plan.


5. OPERATING SEGMENTS

   The following table presents information about the Company's two operating
   segments:

                                    Health     Therapeutic
                                   Products    Development      Total
                                  -----------  ------------  ------------
   Quarter ended June 30, 2000:
     Revenues from external
      customers                   $  779,000    $       --   $   779,000
     Intersegment revenues                --            --            --
     Net loss                       (736,000)     (365,000)   (1,101,000)
     As of June 30, 2000 -
      Total assets                 2,970,000     5,368,000     8,338,000

                                       7
<PAGE>

                                        Health     Therapeutic
                                       Products    Development      Total
                                     ------------  ------------  ------------
   Quarter ended June 30, 1999:
      Revenues from external
       customers                     $ 2,655,000   $    46,000   $ 2,701,000
      Intersegment revenues                   --       279,000       279,000
      Net loss                          (834,000)     (948,000)   (1,782,000)
      As of June 30, 1999 -
        Total assets                   5,067,000     1,220,000     6,287,000

   Six months ended June 30, 2000:
      Revenues from external
       customers                     $ 1,722,000   $        --   $ 1,722,000
      Intersegment revenues                   --            --            --
      Net loss                        (1,365,000)     (704,000)   (2,069,000)

   Six months ended June 30, 1999:
      Revenues from external
       customers                     $ 4,083,000   $    74,000   $ 4,157,000
      Intersegment revenues                   --       303,000       303,000
      Net loss                        (1,243,000)   (1,730,000)   (2,973,000)


6. SUBSEQUENT EVENT

   At a meeting held August 1, 2000, the Company's board of directors decided to
   develop additional information as to the value of the Company's Health
   Products segment, for the purpose of reaching a final decision on whether to
   continue operations or develop a formal plan for disposal of this business
   segment. To this end, the board has received a nonexclusive offer from two
   employees to purchase the Health Products assets. As a result, a special
   committee of the board has been charged with the responsibility of completing
   a full due diligence investigation of this offer, as well as other avenues of
   sale and reporting back to the full board with its recommendation. At the
   present time, the specter of a sale as well as specific terms are not defined
   sufficiently to quantify the financial results of any agreed upon disposition
   or whether continuing operations is a preferable alternative. The Company
   believes that it is reasonable for the special committee to complete its work
   and to issue its recommendation during the balance of calendar 2000, at which
   time it is expected to be clearer as to whether a sale of this business
   segment is appropriate.

                                       8
<PAGE>

Item 2. Management's Discussion and Analysis of Financial Condition and Results
of Operations.

CERTAIN STATEMENTS SET FORTH BELOW CONSTITUTE "FORWARD-LOOKING STATEMENTS"
WITHIN THE MEANING OF THE PRIVATE SECURITIES LITIGATION REFORM ACT OF 1995.
STATEMENTS THAT EXPRESSLY OR BY IMPLICATION PREDICT FUTURE RESULTS, PERFORMANCE
OR EVENTS ARE FORWARD-LOOKING. THE WORDS "BELIEVES," "PLANS," "EXPECTS,"
"ANTICIPATES," "ESTIMATES," AND SIMILAR EXPRESSIONS ALSO IDENTIFY FORWARD-
LOOKING STATEMENTS.  THE FORWARD-LOOKING STATEMENTS INVOLVE KNOWN AND UNKNOWN
RISKS, UNCERTAINTIES AND OTHER FACTORS THAT MAY CAUSE THE ACTUAL RESULTS,
PERFORMANCE OR ACHIEVEMENTS OF THE COMPANY OR INDUSTRY RESULTS TO BE MATERIALLY
DIFFERENT FROM ANY FUTURE RESULTS, PERFORMANCE OR ACHIEVEMENTS EXPRESSED OR
IMPLIED BY THE FORWARD-LOOKING STATEMENTS.  WITH RESPECT TO THE COMPANY, THESE
FACTORS INCLUDE UNCERTAINTY OF ADDITIONAL FUNDING; LOSS OR IMPAIRMENT OF SOURCES
OF CAPITAL; DEPENDENCE ON STRATEGIC PARTNERS; UNCERTAINTIES RELATING TO PATENTS
AND PROPRIETARY INFORMATION; DEPENDENCE ON KEY PERSONNEL; TECHNOLOGICAL CHANGE
AND COMPETITION AND CHANGES IN LAWS OR REGULATIONS.  GIVEN THESE UNCERTAINTIES
READERS ARE CAUTIONED NOT TO PLACE UNDUE RELIANCE ON THE FORWARD-LOOKING
STATEMENTS.  THE COMPANY DOES NOT INTEND TO UPDATE ANY FORWARD-LOOKING
STATEMENTS.

FINANCIAL CONDITION, LIQUIDITY AND CAPITAL RESOURCES

   The Company's working capital increased during the first half of 2000 by
   $4,129,000, from $924,000 at December 31, 1999 to $5,053,000 at June 30,
   2000. The increase in working capital resulted primarily from the net
   proceeds from issuance of common stock of $5,868,000, offset in part by the
   effect of the net loss for the period ($2,069,000 less non-cash charges of
   $276,000).

   Cash and cash equivalents increased from $789,000 at December 31, 1999 to
   $4,564,000 at June 30, 2000.

   While the Company believes that its new therapeutic products and technologies
   show considerable promise, its ability to realize significant revenues
   therefrom is dependent upon the Company's success in developing business
   alliances with biotechnology and/or pharmaceutical companies that have the
   required resources to develop and market certain of these products. There is
   no assurance that the Company's effort to develop such business alliances
   will be successful.

   The Company expects to continue to report losses in 2000 as the level of
   expenses is expected to continue to exceed revenues. The Company can give no
   assurances as to when and if its revenues will exceed its expenses.

                                       9
<PAGE>

           RESULTS OF OPERATIONS - THREE MONTHS ENDED JUNE 30, 2000
                COMPARED WITH THREE MONTHS ENDED JUNE 30, 1999


Possible Divestiture of Assets

   At a meeting held August 1, 2000, the Company's board of directors decided to
   develop additional information as to the value of the Company's Health
   Products segment, for the purpose of reaching a final decision on whether to
   continue operations or develop a formal plan for disposal of this business
   segment. To this end, the board has received a nonexclusive offer from two
   employees to purchase the Health Products assets. As a result, a special
   committee of the board has been charged with the responsibility of completing
   a full due diligence investigation of this offer, as well as other avenues of
   sale and reporting back to the full board with its recommendation. At the
   present time, the specter of a sale as well as specific terms are not defined
   sufficiently to quantify the financial results of any agreed upon disposition
   or whether continuing operations is a preferable alternative. The Company
   believes that it is reasonable for the special committee to complete its work
   and to issue its recommendation during the balance of calendar 2000, at which
   time it is expected to be clearer as to whether a sale of this business
   segment is appropriate. Although a formal plan for this possible divestiture
   has not been put in place, it is anticipated that all of the assets that are
   currently generating revenues for the Company may either be sold to a third
   party or spun off to the Company's shareholders. Upon completion of such a
   restructuring, the Company would no longer have a source of current revenues
   and the Company's continued operations would be wholly dependent upon
   additional capital financing until such time as revenues can be generated
   from its therapeutic development programs.


Revenues

   The Company's revenues for the quarters ended June 30, 2000 and 1999 were as
   follows:

                                              2000         1999

     Research assays and fine chemicals    $  293,000   $  330,000
     Therapeutic drug monitoring assays       174,000      599,000
     Instruments                              292,000      308,000
     Bovine superoxide dismutase (bSOD)
      for research and human use                   --      456,000
     Sale of rights to therapeutic drug
      monitoring assays                            --      911,000
     Other                                     20,000       97,000
                                           ----------   ----------
                                           $  779,000   $2,701,000
                                           ==========   ==========

   Sales of research assays and fine chemicals declined by $37,000 from $330,000
   in the second quarter of 1999 to $293,000 in the second quarter of 2000 due
   to a decline in sales volumes.

                                       10
<PAGE>

   Revenues from sales of therapeutic drug monitoring assays declined in the
   second quarter of 2000 as compared to the second quarter of 1999 resulting in
   a decrease in sales of $425,000. Effective June 28, 1999, the Company sold
   the intellectual property, contract rights and finished goods inventory
   relating to its therapeutic drug monitoring assays. Sales of therapeutic drug
   monitoring assays for the second quarter of 1999 include $158,000 for the
   sale of the therapeutic drug monitoring finished goods inventory. Therapeutic
   drug monitoring assay revenues in the second quarter of 2000 represent
   contract sales of assays and services to the purchaser of the rights to this
   technology. Such revenues are expected to continue to be less than the level
   prior to July 1999. Revenues from therapeutic drug monitoring assay sales and
   related services may terminate at the end of the third quarter of 2000, when
   the contract to manufacture product for the purchaser of the technology
   expires.

   Revenue from instrument sales and development declined by $16,000, from
   $308,000 in the second quarter of 1999 to $292,000 in the second quarter of
   2000. This decrease resulted from reduced orders from customers. Since early
   1999, the Company has not invested in any significant marketing efforts to
   replace lost instrument customers.

   Sales of bSOD in the second quarter of 1999 were primarily the result of one
   shipment of bulk bSOD which has not been repeated in 2000.


Costs and Expenses

   Cost of sales was 99% of revenues for the second quarter 1999 and increased
   to 107% of revenues for the second quarter of 2000. Revenues for the second
   quarter of 1999 include $911,000 for the sale of rights to the Company's
   therapeutic drug monitoring assays, and expenses include $1,279,000 for the
   cost of that technology. Excluding the sale of the therapeutic drug
   monitoring technology and related cost, cost of sales for the second quarter
   of 1999 was approximately 79% of revenues. The increase in the cost of sales
   as a percentage of sales in the second quarter of 2000 is due primarily to
   the effect of the fixed manufacturing costs for the Company's products being
   spread over a lower manufacturing and sales volume. Cost of product sales
   declined from $1,406,000 in the second quarter of 1999 to $833,000 in the
   second quarter of 2000, but this decrease was not in proportion to the
   decrease in sales volumes.

   Research and development expenses decreased from $952,000 in the second
   quarter of 1999 to $447,000 in the second quarter of 2000. The decrease in
   research and development expenses resulted primarily from the closure of the
   Company's French research laboratory in the second quarter of 1999.

   Selling, general and administrative expenses decreased from $830,000 in the
   second quarter of 1999 to $642,000 in the second quarter of 2000. A reduction
   in personnel costs contributed approximately $128,000 to this decrease.

                                       11
<PAGE>

Interest Income

   Interest income for the second quarter of 2000 was more than for the second
   quarter of 1999 because the Company had more cash available for investment
   during 2000.


Net Loss

   The Company continued to experience losses in the second quarter of 2000. The
   second quarter 2000 net loss of $1,101,000 ($.12 per share-basic and diluted)
   was $681,000 less than the $1,782,000 ($.23 per share-basic and diluted) net
   loss for the second quarter of 1999. The decrease in the net loss is
   primarily due to the decreases in research and development and selling,
   general and administrative costs.

   The Company expects to incur a substantial net loss for 2000. If the Company
   develops substantial new revenue sources or if substantial additional capital
   is raised through further sales of securities, the Company plans to continue
   to invest in research and development activities and incur sales, general and
   administrative expenses in amounts greater than its anticipated near-term
   product margins. If the Company is unable to raise sufficient additional
   capital or to develop new revenue sources, it will have to cease, or severely
   curtail, its operations. In this event, while expenses will be reduced,
   expense levels, and the potential write down of various assets, would still
   be in amounts greater than anticipated revenues. The Company expects that
   additional capital will be required in 2001.

                                       12
<PAGE>

            RESULTS OF OPERATIONS - SIX MONTHS ENDED JUNE 30, 2000
                 COMPARED WITH SIX MONTHS ENDED JUNE 30, 1999


Revenues

   The Company's revenues for the six-month periods ended June 30, 2000 and 1999
   were as follows:

                                                           2000        1999
Sales
  Research assays and fine chemicals                    $  609,000  $  736,000

  Therapeutic drug monitoring assays                       464,000   1,083,000

  Instruments                                              625,000     795,000

  Bovine superoxide dismutase (bSOD)
   for research and human use                                   --     460,000

Sale of rights to therapeutic drug monitoring assays            --     911,000

Other                                                       24,000     172,000
                                                        ----------  ----------

                                                        $1,722,000  $4,157,000
                                                        ==========  ==========

   Sales of research assays and fine chemicals declined by $127,000, from
   $736,000 in the first half of 1999 to $609,000 in the first half of 2000.
   This decrease was due primarily to the sale of certain products that became
   surplus when the Company's French laboratory was closed in early 1999.

   Effective June 28, 1999, the Company sold the intellectual property, contract
   rights and finished goods inventory relating to its therapeutic drug
   monitoring assays. The Company recognized $911,000 as compensation for the
   intellectual property and contract rights. Sales of the Company's therapeutic
   drug monitoring assays decreased by $619,000, from $1,083,000 in the first
   six months of 1999 to $464,000 in the first six months of 2000. Sales of
   therapeutic drug monitoring assays for the six months ended June 30, 1999
   include $158,000 for the sale of the therapeutic drug monitoring finished
   goods inventory. Therapeutic drug monitoring assay revenues in the first six
   months of 2000 represent contract sales of assays and services to the
   purchaser of the rights to this technology. Such revenues are expected to
   continue to be less than the level prior to July 1999. Revenues from
   therapeutic drug monitoring assay sales and related services may terminate at
   the end of the third quarter of 2000, when the contract to manufacture
   product for the purchaser of the technology expires.

                                       13
<PAGE>

   Revenue from instrument sales and development declined by $170,000, from
   $795,000 in the first half of 1999 to $625,000 in the first half of 2000.
   This decrease resulted from reduced orders from customers. Since early 1999,
   the Company has not invested in any significant marketing efforts to replace
   lost instrument customers.

   Sales of bSOD in the first half of 1999 were primarily the result of one
   shipment of bulk bSOD to the Company's Spanish licensee. No significant sales
   of bulk bSOD were made during 2000.

   Other revenues in the first half of 1999 included a $50,000 royalty payment
   that did not recur in the first half of 2000.


Costs and Expenses

   Cost of sales was 89% of revenues for the first half of 1999 and increased to
   98% of product sales for the first half of 2000. Revenues for 1999 include
   $911,000 for the sale of rights to the Company's therapeutic drug monitoring
   assays, and expenses include $1,279,000 for the cost of that technology.
   Excluding the sale of the therapeutic drug monitoring technology and related
   cost, cost of sales for the first half of 1999 was approximately 74% of
   revenues. The increase in the cost of sales as a percentage of sales in 2000
   is due primarily to the effect of the fixed manufacturing costs for the
   Company's products being spread over a lower manufacturing and sales volume.
   Excluding the technology sale, sales volume for the first half of 2000 was
   approximately 47% less than that of the first half of 1999. Cost of product
   sales declined from $2,413,000 in the first half of 1999 to $1,685,000 in the
   first half of 2000, but this decrease was not in proportion to the decrease
   in sales volumes.

   Research and development expenses decreased from $1,722,000 in the first half
   of 1999 to $785,000 in the first half of 2000. The decrease in research and
   development expenses resulted primarily from costs in the first half of 1999
   relating to the closure of the Company's French research facility and
   termination of its employees.

   Selling, general and administrative expenses decreased by $324,000, from
   $1,688,000 in the first half of 1999 to $1,364,000 in the first half of 2000.
   Personnel reductions accounted for approximately $145,000 of the decrease.
   Reduced advertising expense contributed an additional $42,000 to the
   reduction.


Interest Income

   Interest income for the first half of 2000 was more than for the first half
   of 1999 because the Company had more cash available for investment during
   2000.

                                       14
<PAGE>

Net Loss

   The Company continued to experience losses in the first six months of 2000.
   The first half 2000 net loss of $2,069,000 ($.24 per share-basic and diluted)
   was $904,000 less than the $2,973,000 ($.38 per share-basic and diluted) net
   loss for the first half of 1999. The decrease in the net loss is primarily
   due to reductions in research and development and selling, general and
   administrative expenses, partially offset by reduced margins on product
   sales.




                          PART II.  OTHER INFORMATION

Item 2.   Changes in Securities and Use of Proceeds.

   In March 2000 the Company issued 1,010,868 shares of its common stock and
   warrants to purchase 2,021,736 shares of its common stock to eight accredited
   investors. Gross proceeds from the sale of these securities were $4,802,000,
   including $4,600,000 in cash and $202,000 in exchange for a note and accrued
   interest. The securities were sold in a private placement pursuant to
   Regulation D of the rules of the Securities and Exchange Commission.

   In April 2000 the Company completed the second and final closing of its
   private placement pursuant to Regulation D by issuing an additional 366,081
   shares of its common stock and warrants to purchase 732,162 shares of its
   common stock to three accredited investors, two of which also acquired shares
   and warrants in the March closing. Gross proceeds from the April closing were
   $1,450,000.

   In total, warrants to purchase 2,753,898 shares of common stock were issued
   to investors in the private placement. The number of shares subject to the
   warrants by exercise price is as follows:

               Exercise             Shares subject
                 Price                to warrants
                 -----                -----------
                 $7.13                 1,021,394
                 $5.94                 1,021,394
                 $5.91                   355,555
                 $4.92                   355,555

   The $5.94 and $4.92 warrants expire one year from issuance.  The $7.13 and
   $5.91 warrants expire two years from issuance.

   In connection with this sale of securities the Company has paid or will pay
   to its placement agents $219,000 in cash commissions together with warrants
   to purchase 155,000 shares of the Company's common stock at an exercise price
   of $5.94 per share.

Item 6. Exhibits and Reports on Form 8-K.

                                       15
<PAGE>

(a) Exhibits - See Exhibit Index on page 16.

(b) Reports on Form 8-K


    On April 12, 2000, the Company filed a report on Form 8-K demonstrating
    compliance with a minimum net tangible asset requirement that had been
    required by a Nasdaq Listing Qualifications Panel.


                                  SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.

                                        OXIS International, Inc.


August 10, 2000                         By /s/ Paul C. Sharpe
                                           ------------------------------
                                           Paul C. Sharpe
                                           Chief Executive Officer



August 10, 2000                         By /s/ Jon S. Pitcher
                                           ------------------------------
                                           Jon S. Pitcher
                                           Chief Financial Officer

                                       16
<PAGE>

                                 EXHIBIT INDEX

Exhibit                                                   Page
Number        Description of Document                    Number


 10(a)        Executive Employment Agreement dated
              April 3, 2000, between the Company and
              Jon S. Pitcher

 10(b)        Executive Employment Agreement dated
              April 3, 2000, between the Company and
              Humberto V. Reyes

 27(a)        Financial data schedule


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