OXIS INTERNATIONAL INC
10-Q, 2000-11-14
PHARMACEUTICAL PREPARATIONS
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<PAGE>

                      SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, DC 20549

                                   FORM 10-Q


   X      Quarterly report pursuant to Section 13 or 15(d) of the Securities
-------   Exchange Act of 1934 for the quarterly period ended September 30,
          2000.

                                      or

          Transition report pursuant to Section 13 or 15(d) of the
-------   Securities Exchange Act of 1934 for the transition period from ___ to
          _______.

                         Commission File Number O-8092


                           OXIS INTERNATIONAL, INC.

            (Exact name of registrant as specified in its charter)


              Delaware                                 94-1620407
    ---------------------------------     -----------------------------------
     (State or other jurisdiction of              (I.R.S. Employer
      incorporation or organization)               Identification No.)


        6040 N. Cutter Circle, Suite 317, Portland, Oregon          97217
    -------------------------------------------------------------------------
          (Address of principal executive offices)               (Zip Code)


                                (503) 283-3911
    -------------------------------------------------------------------------
             (Registrant's telephone number, including area code)



Indicate by check mark whether the Registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the preceding 12 months (or for such shorter period that the Registrant was
required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days.

                      YES  X      NO
                          ---        ---


At September 30, 2000, the issuer had outstanding the indicated number of shares
                          of common stock:  9,370,677
<PAGE>

                        PART I.  FINANCIAL INFORMATION

Item 1.   Financial Statements.

               CONSOLIDATED STATEMENT OF OPERATIONS (UNAUDITED)
<TABLE>
<CAPTION>

                                              Three Months Ended           Nine Months Ended
                                                 September 30                September 30
                                          -------------------------   --------------------------
                                               2000          1999         2000           1999
<S>                                       <C>           <C>           <C>           <C>
Revenues                                  $ 1,039,000   $   898,000   $ 2,761,000    $ 5,055,000

Costs and expenses:
  Cost of product sales                       690,000       818,000     2,375,000      3,231,000
  Cost of technology sold                          --            --            --      1,279,000
  Research and development                    436,000       323,000     1,221,000      2,045,000
  Selling, general and administrative       1,072,000       810,000     2,436,000      2,498,000
                                          -----------   -----------   -----------    -----------
     Total costs and expenses               2,198,000     1,951,000     6,032,000      9,053,000
                                          -----------   -----------   -----------    -----------
Operating loss                             (1,159,000)   (1,053,000)   (3,271,000)    (3,998,000)
Interest income                                57,000        14,000       144,000         39,000
Interest expense                              (17,000)      (20,000)      (61,000)       (73,000)
                                          -----------   -----------   -----------    -----------
Net loss                                   (1,119,000)   (1,059,000)   (3,188,000)    (4,032,000)
Other comprehensive loss -
  foreign currency
  translation adjustments                     (20,000)       (2,000)      (40,000)       (33,000)
                                          -----------   -----------   -----------    -----------
Comprehensive loss                        $(1,139,000)  $(1,061,000)  $(3,228,000)   $(4,065,000)
                                          ===========   ===========   ===========    ===========

Net loss per share - basic and diluted    $      (.12)  $      (.13)  $      (.35)   $      (.51)
                                          ===========   ===========   ===========    ===========

Weighted average number of
  shares used in computation -
  basic and diluted                         9,370,667     7,906,250     8,987,552      7,874,678
                                          ===========   ===========   ===========    ===========
</TABLE>

                                       2
<PAGE>

                          CONSOLIDATED BALANCE SHEETS
                                  (Unaudited)
<TABLE>
<CAPTION>

                                 September 30,        December 31,
                                     2000                1999
<S>                              <C>                  <C>
ASSETS

Current assets:
  Cash and cash equivalents        $3,203,000         $  789,000
  Accounts receivable                 736,000          1,072,000
  Inventories                       1,297,000          1,327,000
  Prepaid and other                   123,000             37,000
                                   ----------         ----------

     Total current assets           5,359,000          3,225,000

Furniture and equipment, net          691,000            808,000

Technology for developed products     727,000            864,000

Other assets                          330,000            287,000
                                   ----------         ----------

     Total assets                  $7,107,000         $5,184,000
                                   ==========         ==========
</TABLE>

                                       3
<PAGE>

                          CONSOLIDATED BALANCE SHEETS
                                  (Unaudited)
<TABLE>
<CAPTION>

                                                       September 30,       December 31,
                                                           2000               1999
<S>                                                    <C>                 <C>

LIABILITIES AND SHAREHOLDERS' EQUITY

Current liabilities:
  Notes payable                                        $    446,000        $    681,000
  Accounts payable                                          561,000           1,131,000
  Accrued payroll, payroll taxes and other                  316,000             395,000
  Current portion of long-term debt                          95,000              94,000
                                                       ------------        ------------
     Total current liabilities                            1,418,000           2,301,000

Long-term debt due after one year                           160,000             194,000

Shareholders' equity:
  Preferred stock - $.01 par value; 15,000,000 shares
   authorized:
     Series B - 428,389 shares issued and outstanding
     at September 30, 2000 and December 31, 1999
     (liquidation preference of $1,000,000)                   4,000               4,000
     Series C - 608,536 shares issued and outstanding
     at September 30, 2000 and December 31, 1999              6,000               6,000
  Common stock - $.001 par value; 95,000,000 shares
   authorized; 9,370,677 shares issued and outstanding
   at September 30, 2000
   (7,928,784 at December 31, 1999)                           9,000               8,000
  Additional paid in capital                             58,823,000          52,756,000
  Accumulated deficit                                   (52,938,000)        (49,750,000)
  Accumulated other comprehensive loss -
     foreign currency translation adjustment               (375,000)           (335,000)
                                                       ------------        ------------

     Total shareholders' equity                           5,529,000           2,689,000
                                                       ------------        ------------

Total liabilities and shareholders' equity             $  7,107,000        $  5,184,000
                                                       ============        ============
</TABLE>

                                       4
<PAGE>

                     CONSOLIDATED STATEMENTS OF CASH FLOWS
                                  (Unaudited)

<TABLE>
<CAPTION>
                                                                     Nine Months Ended
                                                                       September 30,
                                                            -----------------------------------
                                                                 2000                1999
<S>                                                          <C>                 <C>

Cash flows from operating activities:
 Net loss                                                    $(3,188,000)        $(4,032,000)
 Adjustments to reconcile net loss to cash
  used for operating activities:
  Depreciation and amortization                                  386,000             708,000
  Gain on sale of land and building                                   --             (16,000)
  Loss on sale of technology                                          --             368,000
  Cash proceeds from sale of technology                               --             342,000
  Changes in assets and liabilities:
   Accounts receivable                                           333,000             121,000
   Inventories                                                    40,000             168,000
   Other current assets                                          (87,000)            166,000
   Accounts payable                                             (566,000)             49,000
   Customer deposits                                                  --            (120,000)
   Accrued payroll, payroll taxes and other                      (43,000)           (263,000)
                                                             -----------         -----------

     Net cash used for operating activities                   (3,125,000)         (2,509,000)

Cash flows from investing activities:
 Proceeds from sale of land and building                              --           1,959,000
 Purchases of equipment                                         (123,000)           (195,000)
 Additions to other assets                                       (93,000)            (65,000)
 Other, net                                                       11,000              16,000
                                                             -----------         -----------

     Net cash provided by (used for) investing activities       (205,000)          1,715,000

Cash flows from financing activities:
 Proceeds from issuance of stock, net of related costs         5,868,000                  --
 Repayment of short-term borrowings                              (75,000)            (40,000)
 Repayment of long-term debt                                     (34,000)         (1,519,000)
                                                             -----------         -----------

     Net cash provided by (used for) financing activities      5,759,000          (1,559,000)

Effect of exchange rate changes on cash                          (15,000)             23,000
                                                             -----------         -----------

Net increase (decrease) in cash and cash equivalents           2,414,000          (2,330,000)

Cash and cash equivalents - beginning of period                  789,000           2,575,000
                                                             -----------         -----------

Cash and cash equivalents - end of period                    $ 3,203,000         $   245,000
                                                             ===========         ===========

Non-cash transactions:
  Issuance of common stock in exchange
     for cancellation of notes and accrued interest          $   202,000         $        --
  Note received as part of proceeds from sale
     of technology                                                    --             569,000
  Conversion of 199,342 shares of Series C Preferred
     Stock into 57,588 shares of common stock                         --             233,000
</TABLE>

                                       5
<PAGE>

             CONDENSED NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

1.   FINANCIAL STATEMENTS AND CONDENSED NOTES

     The unaudited consolidated financial statements, which have been prepared
     in accordance with the instructions to Form 10-Q, do not include all of the
     information and notes required by accounting principles generally accepted
     in the United States of America for complete financial statements. All
     adjustments considered necessary by management for a fair presentation have
     been included. Operating results for interim periods are not necessarily
     indicative of the results that may be expected for the full year.

     An annual report (Form 10-K) has been filed with the Securities and
     Exchange Commission ("Commission") for the year ended December 31, 1999.
     That report contains, among other information, a description of the
     Company's business, audited financial statements, notes to the financial
     statements, the report of the independent auditors and management's
     discussion and analysis of results of operations and financial condition.
     Readers of this report are presumed to be familiar with that annual report.


2.   INVENTORIES

     Inventories are stated at the lower of cost or market. Cost has been
     determined by using the first-in, first-out method. Inventories at
     September 30, 2000 and December 31, 1999, consisted of the following:

<TABLE>
<CAPTION>
                               September 30,    December 31,
                                   2000            1999
         <S>                   <C>             <C>
          Raw materials         $  694,000      $  492,000
          Work in process          403,000         438,000
          Finished goods           200,000         397,000
                                ----------      ----------

          Total                 $1,297,000      $1,327,000
                                ==========      ==========
</TABLE>

3.   SHAREHOLDERS' EQUITY

     In April 2000 the Company completed a private placement of units,
     consisting of one share of the Company's common stock plus warrants to
     purchase two shares of the Company's common stock (the "Units"), primarily
     to a series of institutional investors. The Units were priced at the Nasdaq
     closing price for the Company's common stock the day prior to the signing
     of the subscription agreements relating to the purchase of such Units. The
     price per Unit ranged from $3.94 to $4.75. A total of 1,376,950 common
     shares and warrants to purchase 2,753,000 common shares were issued in
     exchange for gross proceeds of $6,050,000 in cash and conversion of
     $202,000 of short-term notes and accrued interest

                                       6
<PAGE>

     payable. The exercise price of one-half of the warrants issued in the
     private placement is equal to 125% of the price paid per Unit. The exercise
     price of the other half of the warrants is equal to 150% of the price paid
     per Unit.

     The Company issued additional warrants to its placement agents giving the
     agents the right to acquire 155,000 common shares at an exercise price of
     $5.94 per share.

     The Company has filed a preliminary registration statement with the
     Commission registering the common shares, and the common shares issuable
     upon exercise of the warrants, issued in the private placement.

4.   STOCK OPTIONS

     The Company has a stock incentive plan under which 1,365,000 shares of the
     Company's common stock are reserved for issuance (the "Plan"). The Plan
     permits the Company to grant stock options to acquire shares of the
     Company's common stock, award stock bonuses of the Company's common stock,
     and grant stock appreciation rights. During the nine months ended September
     30, 2000, options to purchase 170,389 shares at exercise prices ranging
     from $1.375 to $2.125 have been issued under the Plan. Options to purchase
     an additional 441,111 common shares at exercise prices ranging from $1.3125
     to $1.9125 have also been issued, subject to shareholder approval of an
     amendment to the Plan.

     The Company's board of directors has also approved additional option grants
     outside the Plan to purchase 400,000 common shares at an exercise price of
     $1.5625 and 25,000 common shares at an exercise price of $1.375.

5.   OPERATING SEGMENTS

     The following table presents information about the Company's two operating
     segments:

<TABLE>
<CAPTION>
                                         Health           Therapeutic
                                        Products          Development         Total
                                        --------          -----------         -----
<S>                                    <C>               <C>              <C>
  Quarter ended September 30, 2000:
     Revenues from external
      customers                        $1,039,000         $       --      $ 1,039,000
     Intersegment revenues                     --                 --               --
     Net loss                            (443,000)          (676,000)      (1,119,000)
     As of September 30, 2000 -
      Total assets                      3,074,000          4,033,000        7,107,000
</TABLE>

                                       7
<PAGE>

<TABLE>
<CAPTION>
                                          Health           Therapeutic
                                         Products          Development       Total
                                         --------          -----------       -----
<S>                                     <C>               <C>              <C>
  Quarter ended September 30, 1999:
     Revenues from external
      customers                         $   898,000       $        --      $   898,000
     Intersegment revenues                       --                --               --
     Net loss                              (735,000)         (324,000)      (1,059,000)
     As of September 30, 1999 -
       Total assets                       4,212,000         1,027,000        5,239,000

  Nine months ended September 30, 2000:
     Revenues from external
      customers                         $ 2,761,000       $        --      $ 2,761,000
     Intersegment revenues                       --                --               --
     Net loss                            (1,808,000)       (1,380,000)      (3,188,000)

  Nine months ended September 30, 1999:
     Revenues from external
      customers                         $ 4,981,000       $    74,000      $ 5,055,000
     Intersegment revenues                       --           301,000          301,000
     Net loss                            (1,978,000)       (2,054,000)      (4,032,000)
</TABLE>

6.   HEALTH PRODUCTS SEGMENT

     At a meeting held August 1, 2000, the Company's board of directors decided
     to develop additional information as to the value of the Company's Health
     Products segment. At that time the special committee of the board was
     charged with the responsibility of completing an investigation of an offer
     to purchase the Health Products assets, as well as other avenues of sale
     and reporting back to the full board with its recommendations. That offer
     was subsequently withdrawn. The Company believes that it is reasonable for
     the special committee to complete its work and to issue its recommendation
     during the balance of calendar 2000, at which time it is expected to be
     clearer as to whether a sale of this business segment is appropriate.

7.   LEGAL MATTERS

     The Company is involved in litigation with a former employee and majority
     owner of Innovative Medical Systems Corp., acquired by the Company in 1997.
     The Company is unable to predict the outcome of this litigation.

                                       8
<PAGE>

Item 2.  Management's Discussion and Analysis of Financial Condition and Results
of Operations.

CERTAIN STATEMENTS SET FORTH BELOW CONSTITUTE "FORWARD-LOOKING STATEMENTS"
WITHIN THE MEANING OF THE PRIVATE SECURITIES LITIGATION REFORM ACT OF 1995.
STATEMENTS THAT EXPRESSLY OR BY IMPLICATION PREDICT FUTURE RESULTS, PERFORMANCE
OR EVENTS ARE FORWARD-LOOKING. THE WORDS "BELIEVES," "PLANS," "EXPECTS,"
"ANTICIPATES," "ESTIMATES," AND SIMILAR EXPRESSIONS ALSO IDENTIFY FORWARD-
LOOKING STATEMENTS. THE FORWARD-LOOKING STATEMENTS INVOLVE KNOWN AND UNKNOWN
RISKS, UNCERTAINTIES AND OTHER FACTORS THAT MAY CAUSE THE ACTUAL RESULTS,
PERFORMANCE OR ACHIEVEMENTS OF THE COMPANY OR INDUSTRY RESULTS TO BE MATERIALLY
DIFFERENT FROM ANY FUTURE RESULTS, PERFORMANCE OR ACHIEVEMENTS EXPRESSED OR
IMPLIED BY THE FORWARD-LOOKING STATEMENTS. WITH RESPECT TO THE COMPANY, THESE
FACTORS INCLUDE UNCERTAINTY OF ADDITIONAL FUNDING; LOSS OR IMPAIRMENT OF SOURCES
OF CAPITAL; DEPENDENCE ON STRATEGIC PARTNERS; UNCERTAINTIES RELATING TO PATENTS
AND PROPRIETARY INFORMATION; DEPENDENCE ON KEY PERSONNEL; TECHNOLOGICAL CHANGE
AND COMPETITION AND CHANGES IN LAWS OR REGULATIONS. GIVEN THESE UNCERTAINTIES
READERS ARE CAUTIONED NOT TO PLACE UNDUE RELIANCE ON THE FORWARD-LOOKING
STATEMENTS. THE COMPANY DOES NOT INTEND TO UPDATE ANY FORWARD-LOOKING
STATEMENTS.

FINANCIAL CONDITION, LIQUIDITY AND CAPITAL RESOURCES

     The Company's working capital increased during the first nine months of
     2000 by $3,017,000, from $924,000 at December 31, 1999 to $3,941,000 at
     September 30, 2000. The increase in working capital resulted primarily from
     the net proceeds from issuance of common stock of $5,868,000, offset in
     part by the effect of the net loss for the period ($3,188,000 less non-cash
     charges of $386,000).

     Cash and cash equivalents increased from $789,000 at December 31, 1999 to
     $3,203,000 at September 30, 2000.

     While the Company believes that its new therapeutic products and
     technologies show considerable promise, its ability to realize significant
     revenues therefrom is dependent upon the Company's success in developing
     business alliances with biotechnology and/or pharmaceutical companies that
     have the required resources to develop and market certain of these
     products. There is no assurance that the Company's effort to develop such
     business alliances will be successful.

     The Company expects to continue to report losses in 2000 as the level of
     expenses is expected to continue to exceed revenues. The Company can give
     no assurances as to when and if its revenues will exceed its expenses.

                                       9
<PAGE>

         RESULTS OF OPERATIONS - THREE MONTHS ENDED SEPTEMBER 30, 2000
              COMPARED WITH THREE MONTHS ENDED SEPTEMBER 30, 1999

Possible Divestiture of Assets

     At a meeting held August 1, 2000, the Company's board of directors decided
     to develop additional information as to the value of the Company's Health
     Products segment. At that time the special committee of the board was
     charged with the responsibility of completing an investigation of an offer
     to purchase the Health Products assets, as well as other avenues of sale
     and reporting back to the full board with its recommendations. That offer
     was subsequently withdrawn. The Company believes that it is reasonable for
     the special committee to complete its work and to issue its recommendation
     during the balance of calendar 2000, at which time it is expected to be
     clearer as to whether a sale of this business segment is appropriate.
     Although a decision regarding this possible divestiture has not been made,
     it is possible that all of the assets that are currently generating
     revenues for the Company may either be sold to a third party or spun off to
     the Company's shareholders. Upon completion of such a restructuring, the
     Company would no longer have a source of current revenues and the Company's
     continued operations would be wholly dependent upon additional capital
     financing until such time as revenues can be generated from its therapeutic
     development programs.

Revenues

     The Company's revenues for the quarters ended September 30, 2000 and 1999
  were as follows:

<TABLE>
<CAPTION>
                                                   2000         1999
       <S>                                     <C>            <C>
       Research assays and fine chemicals      $  437,000     $295,000
       Therapeutic drug monitoring assays         262,000      228,000
       Instruments                                333,000      272,000
       Other                                        7,000      103,000
                                               ----------     --------
                                               $1,039,000     $898,000
                                               ==========     ========
</TABLE>

     Sales of research assays and fine chemicals increased by $142,000 from
     $295,000 in the third quarter of 1999 to $437,000 in the third quarter of
     2000. Most of the increase in sales is due to $116,000 in sales of l-
     ergothioneine in the third quarter of 2000 compared to less than $1,000 in
     the third quarter of 1999.

     Therapeutic drug monitoring assay revenues represent contract sales of
     assays and services to the purchaser of the rights to this technology. The
     contract to manufacture therapeutic drug

                                       10
<PAGE>

     monitoring assays for the purchaser of the technology expired at the end of
     the third quarter of 2000. The Company is negotiating terms to continue
     manufacturing these products through the fourth quarter of 2000, at which
     time it expects to sell its remaining inventories to the purchaser of the
     technology and discontinue manufacturing therapeutic drug monitoring
     assays.

     Revenue from instrument sales and development increased by $61,000, from
     $272,000 in the third quarter of 1999 to $333,000 in the third quarter of
     2000.

     Other revenues for the third quarter of 1999 included $55,000 in sales of
     Palosein. The Company is negotiating the sale of the Palosein product, and
     sales of Palosein in 2000 have been insignificant.

Costs and Expenses

     Cost of sales was 91% of revenues for the third quarter of 1999 and
     decreased to 66% of revenues for the third quarter of 2000. The decline in
     cost of sales as a percentage of revenues is attributable primarily to a
     change in the mix of sales of research assays and fine chemicals. Sales of
     products with better margins in 2000 combined with increased sales volumes
     resulted in a $187,000 increase in gross margin from sales of research
     assays and fine chemicals.

     Research and development expenses increased from $323,000 in the third
     quarter of 1999 to $436,000 in the third quarter of 2000. The increase in
     research and development expenses resulted primarily from a settlement with
     two former French research employees resulting in an expense of $59,000 in
     the third quarter of 2000 and a $52,000 increase in research and
     development expenses by the Company's Health Products segment relating to
     development of new research assays and new uses for the Company's fine
     chemicals.

     Selling, general and administrative expenses increased from $810,000 in the
     third quarter of 1999 to $1,072,000 in the third quarter of 2000. Third
     quarter advertising costs increased by $138,000 in 2000. Most of the
     advertising costs in 2000 relate to the Company's new wellness services
     products. Selling, general and administrative expenses for the third
     quarter of 2000 include approximately $106,000 relating to the start-up of
     the Company's new subsidiary in the United Kingdom.

Interest Income

     Interest income for the third quarter of 2000 was more than for the third
     quarter of 1999 because the Company had more cash available for investment
     during 2000.

                                       11
<PAGE>

Net Loss

     The Company continued to experience losses in the third quarter of 2000.
     The third quarter 2000 net loss of $1,119,000 ($.12 per share-basic and
     diluted) was $60,000 more than the $1,059,000 ($.13 per share-basic and
     diluted) net loss for the third quarter of 1999. The increase in the net
     loss is primarily due to the increases in research and development and
     selling, general and administrative costs, offset by increased profit
     margins.

     The Company expects to incur a substantial net loss for 2000. If the
     Company develops substantial new revenue sources or if substantial
     additional capital is raised through further sales of securities, the
     Company plans to continue to invest in research and development activities
     and incur sales, general and administrative expenses in amounts greater
     than its anticipated near-term product margins. If the Company is unable to
     raise sufficient additional capital or to develop new revenue sources, it
     will have to cease, or severely curtail, its operations. In this event,
     while expenses will be reduced, expense levels, and the potential write
     down of various assets, would still be in amounts greater than anticipated
     revenues. The Company expects that additional capital will be required in
     2001.

         RESULTS OF OPERATIONS - NINE MONTHS ENDED SEPTEMBER 30, 2000
              COMPARED WITH NINE MONTHS ENDED SEPTEMBER 30, 1999

Revenues

     The Company's revenues for the nine-month periods ended September 30, 2000
     and 1999 were as follows:

<TABLE>
<CAPTION>
                                                       2000                1999
<S>                                                 <C>                <C>
     Sales
        Research assays and fine chemicals          $1,015,000         $1,087,000

        Therapeutic drug monitoring assays             726,000          1,311,000

        Instruments                                    958,000          1,067,000

        Bovine superoxide dismutase (bSOD)
          for research and human use                        --            452,000

     Sale of rights to therapeutic drug
       monitoring assays                                    --            911,000

     Other                                              62,000            227,000
                                                    ----------         ----------

                                                    $2,761,000         $5,055,000
                                                    ==========         ==========
</TABLE>

                                       12
<PAGE>

     Sales of research assays and fine chemicals declined by $72,000, from
     $1,087,000 in the first nine months of 1999 to $1,015,000 in the first nine
     months of 2000. This decrease was due primarily to the sale of certain
     products that became surplus when the Company's French laboratory was
     closed in early 1999.

     Effective June 28, 1999, the Company sold the intellectual property,
     contract rights and finished goods inventory relating to its therapeutic
     drug monitoring assays. The Company recognized $911,000 as compensation for
     the intellectual property and contract rights. Sales of the Company's
     therapeutic drug monitoring assays decreased by $585,000, from $1,311,000
     in the first nine months of 1999 to $726,000 in the first nine months of
     2000. Sales of therapeutic drug monitoring assays for the nine months ended
     June 30, 1999 include $158,000 for the sale of the therapeutic drug
     monitoring finished goods inventory. Therapeutic drug monitoring assay
     revenues in the first nine months of 2000 represent contract sales of
     assays and services to the purchaser of the rights to this technology. The
     contract to manufacture therapeutic drug monitoring assays for the
     purchaser of the technology expired at the end of the third quarter of
     2000. The Company is negotiating terms to continue manufacturing these
     products through part or all of the fourth quarter of 2000, at which time
     it expects to sell its remaining inventories to the purchaser of the
     technology and discontinue manufacturing therapeutic drug monitoring
     assays.

     Revenue from instrument sales declined by $109,000, from $1,067,000 in the
     first nine months of 1999 to $958,000 in the first nine months of 2000.
     This decrease resulted from reduced orders from customers. Since early
     1999, the Company has not invested in any significant marketing efforts to
     replace lost instrument customers.

     Sales of bSOD in the first nine months of 1999 were primarily the result of
     one shipment of bulk bSOD to the Company's Spanish licensee. No significant
     sales of bulk bSOD are expected during 2000. The Company has received an
     order for delivery of bulk bSOD in the second or third quarter of 2001. The
     order is for a similar quantity as the sale in the first half of 1999.
     However, due to the decline in the value of the euro compared to the U.S.
     dollar, the current value of the bulk bSOD order is approximately $325,000.

     Other revenues for the first nine months of 1999 included $157,000 in sales
     of Palosein. The Company is negotiating the sale of the Palosein product,
     and sales of Palosein in 2000 have been insignificant. Other revenues for
     the first nine months of 1999 also included a $50,000 royalty payment that
     did not recur in 2000.

Costs and Expenses

     Cost of sales was 89% of revenues for the first nine months of 1999 and
     decreased to 86% of revenues for the first nine months of 2000. Revenues
     for 1999 include $911,000 for the sale of rights to the Company's
     therapeutic drug monitoring assays, and expenses include $1,279,000 for the
     cost of that technology. Excluding the sale of the therapeutic drug
     monitoring technology and related cost, cost of sales for the first nine
     months of 1999 was approximately 78% of revenues. The increase in the cost
     of sales as a percentage of sales

                                       13
<PAGE>

     from 78% in 1999 to 86% in 2000 is due to an increase in the negative gross
     margin from the Company's start-up wellness services program ($75,000 for
     the first nine months of 1999 and $233,000 for the first nine months of
     2000) as well as the effect of the fixed manufacturing costs for the
     Company's products being spread over a lower manufacturing and sales
     volume.

     Research and development expenses decreased from $2,045,000 in the first
     nine months of 1999 to $1,221,000 in the first nine months of 2000. The
     decrease in research and development expenses resulted primarily from costs
     in the first nine months of 1999 relating to the closure of the Company's
     French research facility and termination of its employees.

     Selling, general and administrative expenses decreased by $62,000,
     approximately 2%, from $2,498,000 in the first nine months of 1999 to
     $2,436,000 in the first nine months of 2000.

Interest Income

     Interest income for the first nine months of 2000 was more than for the
     first nine months of 1999 because the Company had more cash available for
     investment during 2000.

Net Loss

     The Company continued to experience losses in the first nine months of
     2000. The net loss for the first nine months of 2000 of $3,188,000 ($.35
     per share-basic and diluted) was $844,000 less than the $4,032,000 ($.51
     per share-basic and diluted) net loss for the first nine months of 1999.
     The decrease in the net loss is primarily due to reductions in research and
     development expenses, partially offset by reduced margins on product sales.


                          PART II.  OTHER INFORMATION

Item 1.   Legal Proceedings.

     In March 2000 the Company filed a complaint in the United States District
     Court for the Eastern District of Pennsylvania against Joseph B. Catarious,
     Jr., a former employee and former majority owner of Innovative Medical
     Systems Corp. ("IMS"). In the complaint the Company seeks to recover
     damages from Mr. Catarious for breaches of representations and warranties
     made by him in the agreement pursuant to which the Company acquired IMS in
     December 1997 (the "IMS Agreement"). Because it believes that Mr. Catarious
     has committed breaches of his representations and warranties and the
     damages claimed exceed the value of the payments in stock that would
     otherwise have been payable to Mr. Catarious in 1999 and 2000, the Company
     has withheld such payments. The Company seeks compensatory damages in
     excess of $150,000 and seeks a judgment that it has properly exercised its
     right of offset, and that it is under no obligation to transfer any
     additional stock or other consideration to Mr. Catarious pursuant to the
     IMS Agreement.

                                       14
<PAGE>

     Mr. Catarious filed a counterclaim in May 2000 and an amended counterclaim
     against the Company and its subsidiary, OXIS Health Products, Inc., in
     August 2000. Mr. Catarious denies having made any misrepresentations, and
     he is claiming damages in excess of $3.5 million for alleged breaches of
     the IMS Agreement and Mr. Catarious' employment agreement.

Item 6.   Exhibits and Reports on Form 8-K.

     (a)  Exhibits - See Exhibit Index on page 16.


                                  SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.

                                          OXIS International, Inc.


November 13, 2000                         By  /s/ Joseph F. Bozman, Jr.
                                             --------------------------
                                             Joseph F. Bozman, Jr.
                                             Chairman

November 13, 2000                         By  /s/ Jon S. Pitcher
                                             --------------------------
                                             Jon S. Pitcher
                                             Chief Financial Officer

                                       15
<PAGE>

                                 EXHIBIT INDEX

      Exhibit                                                     Page
       Number              Description of Document               Number

        27(a)              Financial data schedule

                                       16


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