CHARLES RIVER LABORATORIES INC
S-1/A, 2000-01-11
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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   As submitted to the Securities and Exchange Commission on January 11, 2000
                                                      Registration No. 333-91845
================================================================================
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                             -----------------------

                               AMENDMENT NO. 1 TO
                                    FORM S-1
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933


                             -----------------------

                        Charles River Laboratories, Inc.
             (Exact name of Registrant as specified in its charter)

       Delaware                           2836                    76-0509980
 (State or jurisdiction of     (Primary Standard Industrial    (I.R.S. Employer
incorporation or organization)  Classification Code Number)  Identification No.)

                                                        Thomas Ackerman
                                                    Chief Financial Officer
 251 Ballardvale Street                         Charles River Laboratories, Inc.
  Wilmington, MA 01887                               251 Ballardvale Street
     (978) 658-6000                                   Wilmington, MA 01887
                                                         (978) 658-6000

(Address, including zip code, and           (Name, address, including zip code,
telephone number, including area           and telephone number, including area
code, of Registrant's principal                code, of agent for service)
executive offices)

                             -----------------------

                                   Copies to:

  Richard D. Truesdell, Jr., Esq.                       Greg Ezring
       Davis Polk & Wardwell                         Latham & Watkins
       450 Lexington Avenue                          885 Third Avenue
     New York, New York 10017                    New York, New York 10022

                             -----------------------


     Approximate date of commencement of proposed sale to the public: From time
to time after the effective date.

     If any of the securities being registered on this Form are to be offered on
a delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, please check the following box. [x]

     If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement for the same offering. [ ]

     If this Form is a post-effective amendment filed pursuant to Rule 462(c)
under the Securities Act, check the following box and list the Securities Act
registration number of the earliest effective registration statement for the
same offering. [ ]

     If this Form is a post-effective amendment filed pursuant to Rule 462(d)
under the Securities Act, check the following box and list the Securities Act
registration number of the earliest effective registration statement for the
same offering. [ ]

     If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. [ ]


     The Registrant hereby amends this Registration Statement on such date or
dates as may be necessary to delay its effective date until the Registrant shall
file a further amendment which specifically states that this Registration
Statement shall thereafter become effective in accordance with Section 8(a) of
the Securities Act of 1933 or until the Registration Statement shall become
effective on such date as the SEC, acting pursuant to said Section 8(a), may
determine.


================================================================================
<PAGE>



                                EXPLANATORY NOTE

     This Registration Statement covers the registration of an aggregate
principal amount of $150,000,000 of 13-1/2% series B senior subordinated notes
due 2009 of Charles River Laboratories, Inc. ("Charles River") (the "new notes")
that may be exchanged (the "exchange offer") for equal principal amounts of
Charles River's outstanding 13-1/2% series A senior subordinated notes due 2009
(the "old notes"). This Registration Statement also covers the registration of
the new notes for resale by Donaldson, Lufkin & Jenrette Securities Corporation
in market-making transactions. The complete prospectus relating to the exchange
offer (the "exchange offer prospectus") follows immediately after this
Explanatory Note. Following the exchange offer prospectus are pages relating
solely to such market-making transactions (the "market-making prospectus"),
including alternate front and back cover pages, an alternate "Risk Factors--No
public trading market for the new notes exist" section, an alternate "Use of
Proceeds" section and an alternate "Plan of Distribution" section. In addition,
the market-making prospectus will include references merely to "notes" instead
of to "old notes" and "new notes" and will not include the following captions
(or the information set forth under such captions) in the exchange offer
prospectus: "Summary--The Exchange Offer," "Summary--Consequences of Exchanging
Old Notes pursuant to the Exchange Offer," "The Exchange Offer" and "Material
United States Tax Consequences of the Exchange Offer." All other sections of the
exchange offer prospectus will be included in the market-making prospectus. The
market-making prospectus may also be used by DLJ Investment Partners, L.P., DLJ
Investment Funding, Inc., and DLJ ESC II L.P. to comply with their prospectus
delivery requirements under the Securities Act in connection with any resale
transactions.


<PAGE>



The information in this prospectus is not complete and may be changed. We may
not sell these securities until the registration statement filed with the
Securities and Exchange Commission is effective. This prospectus is not an offer
to sell these securities and it is not soliciting an offer to buy these
securities in any state where the offer or sale is not permitted.



                 SUBJECT TO COMPLETION, DATED JANUARY 11, 2000


PROSPECTUS

                        Charles River Laboratories, Inc.
                               Offers to Exchange
             13-1/2% Series A Senior Subordinated Notes Due 2009 for
               13-1/2% Series B Senior Subordinated Notes Due 2009
           which have been registered under the Securities Act of 1933

     We are offering to exchange an aggregate principal amount of up to
$150,000,000 of our new 13-1/2% series B senior subordinated notes due 2009,
which have been registered under the Securities Act of 1933 for our existing
13-1/2% series A senior subordinated notes due 2009. We issued units consisting
of the old notes and warrants to purchase common stock of our holding company in
a transaction exempt from registration under the Securities Act. We are
registering the warrants and the common stock into which the warrants are
exercisable on a separate "shelf" registration statement.


     The terms of the new notes are identical in all material respects to the
terms of the old notes, except that the new notes will only be guaranteed by CRL
Transaction Company, Inc., a subsidiary of Charles River. The subsidiaries which
guaranteed the old notes have been merged into Charles River Laboratories, Inc.
In addition, the new notes have been registered under the Securities Act. There
is no existing market for the new notes, and Charles River does not intend to
apply for their listing on any securities exchange.


     To exchange your old notes for new notes:


  o  You must complete and send the letter of transmittal that accompanies this
     prospectus to the exchange agent by 5:00 p.m., New York time, on          ,
     2000.


  o  If your old notes are held in book-entry form at The Depository Trust
     Company, you must instruct The Depository Trust Company through your signed
     letter of transmittal that you wish to exchange your old notes for new
     notes. When the exchange offer closes, your Depository Trust Company
     account will be changed to reflect your exchange of old notes for new
     notes.

  o  You should read the section called "The Exchange Offer" for additional
     information on how to exchange your old notes for new notes.


     See "Risk Factors" beginning on page 13 for a discussion of the risk
factors that should be considered by you prior to tendering your old notes in
the exchange offer.


     Neither the Securities and Exchange Commission nor any state securities
commission has approved or disapproved of the securities or passed upon the
adequacy or accuracy of this prospectus. Any representation to the contrary is a
criminal offense.


     The date of this prospectus is                                    , 2000.


                                       iii


<PAGE>




                             -----------------------

                                TABLE OF CONTENTS

                             -----------------------

                                                                           Page
                                                                          -----



Summary.......................................................................1
Risk Factors.................................................................13
Forward-Looking Statements...................................................23
Industry and Market Data.....................................................23
The Transactions.............................................................23
Use of Proceeds..............................................................27
Capitalization...............................................................28
Selected Historical Consolidated Financial Data..............................29
Management's Discussion and Analysis of
     Financial Condition and Results of
     Operations..............................................................31
Business.....................................................................44
Management...................................................................53
Executive Compensation.......................................................56
Security Ownership of Certain Beneficial Owners and Management...............59
Certain Relationships and Related Party
     Transactions............................................................60
Description of New Credit Facility...........................................62
Description of Notes.........................................................64
Certain United States Tax Consequences of the
     Exchange Offer.........................................................112
Plan of Distribution........................................................112
Legal Matters...............................................................113
Independent Accountants.....................................................113
Index to Unaudited Pro Forma Condensed
     Consolidated Financial Data............................................P-1
Index to Consolidated Financial Statements..................................F-1


                             -----------------------


<PAGE>



                                     SUMMARY


     References to the words "Charles River," "CRL," "we," "our," and "us" refer
only to Charles River Laboratories, Inc., its predecessors, its subsidiaries,
its affiliates and its joint ventures. This summary highlights information
contained elsewhere in this prospectus and may not contain all of the
information that is important to you. For a more complete understanding of this
exchange offer, we encourage you to read this entire prospectus carefully.


     Our fiscal year ends on the Saturday closest to December 31. Unless the
context indicates otherwise, whenever we refer in this prospectus to a
particular fiscal year, we mean the fiscal year ending in that particular
calendar year. When we refer to "pro forma" financial results, we mean the
financial results of Charles River and its subsidiaries on a consolidated basis
as if the Transactions (which we define on page 4) had occurred at the beginning
of the relevant time period.

                        CHARLES RIVER LABORATORIES, INC.

Overview


    We are a global market leader in the commercial production and supply of
animal research models, meaning whole, living animals bred in a clean
environment specifically for the purpose of research, most of which are rats and
mice, for use in the discovery, development and testing of new pharmaceuticals.
The expansion of our core capabilities in research models has enabled us to
become a leading supplier of related biomedical products and services in several
specialized niche markets. Our research model capabilities and biomedical
products and services, together with our global distribution network, allow us
to meet the extensive needs of our broad customer base. Our customers consist
primarily of:


   o large pharmaceutical companies, including the ten largest global
     pharmaceutical companies based on 1998 revenues

   o biotechnology, animal health, medical device and diagnostics companies

   o hospitals

   o academic institutions

   o government agencies


     Our facilities are located in 18 countries, including the United States,
Canada, Japan and many European countries. On a pro forma basis, research models
accounted for 62%, and biomedical products and services accounted for 38%, of
net sales for the nine-month period ended September 25, 1999. Over the same time
period, we reported pro forma net sales of $177.1 million and pro forma Adjusted
EBITDA, which means EBITDA, as defined, adjusted for non-recurring, non-cash and
cash items, as appropriate, of $45.4 million.


     Our principal executive offices are located at 251 Ballardvale Street,
Wilmington, MA 01887 and our telephone number is (978) 658-6000.


     Research Models. We have a leading position in the global market for
research models, which primarily consists of rats and mice bred for the specific
purpose of research. The use of research models is often a critical part of
scientific discovery in the life sciences and is required by FDA guidelines as
well as foreign regulatory agencies for new drug approval processes. We focus on
maintaining reliable biosecurity, which refers to the process of insuring that
animal models are produced and maintained in a clean room environment that is
free of viruses, bacteria and other agents which if present could alter research
results when using these models. As a result, we provide consistent product
availability and offer a wide variety of healthy, genetically defined and
specifically targeted


                                        1


<PAGE>
research models. We further differentiate our research models by providing
extensive technical service and support, including scientific oversight from a
team of more than 70 full-time, dedicated professionals specializing in
laboratory animal medicine, pathology, the study of viruses and primates, as
well as molecular biology and genetics.

     Biomedical Products and Services. The principal focus of our biomedical
products and services segment is to meet the research needs of large
pharmaceutical companies as well as biotechnology, animal health, medical device
and diagnostics companies. We are a leading supplier of endotoxin testing kits
that detect fever producing toxins in injectable drugs and devices and are one
of only two FDA validated in vitro alternatives to an animal test. In
particular, such kits are used to test materials for the presence of certain
by-products of bacteria known as endotoxins, which if present and introduced to
the bloodstream can cause serious illness or even death. We manufacture these
kits which are based on extracts from the blood of horseshoe crabs, which
visibly clots in the presence of endotoxin, thereby acting as a test for the
presence of endotoxin. In addition, we are one of the world's largest producers
of specific pathogen free fertile chicken eggs, which are free of most viruses,
bacteria and other harmful agents. We refer to such eggs as "SPF eggs". SPF eggs
are principally used to produce poultry vaccines. Our other biomedical products
and services, many of which are related to technologies developed in our
research model business, include:

   o transgenic animal production, which refers to the breeding of mice
     genetically engineered by a scientist by introducing a gene into the
     mouse that would not have been present naturally


   o medical device testing

   o contract research services

   o comprehensive health monitoring programs, including DNA testing, of animal
     colonies


   o testing services for human protein drug candidates, which are drugs
     developed from human cells rather than from chemical synthesis


   o facility management services

Competitive Strengths


     We have a number of competitive strengths, including:

   o Long-Standing Relationships with an Extensive Customer Base

   o Critical Component of Pharmaceutical Research

   o Leading Market Position

   o Global Presence

   o Experienced and Motivated Management Team


Business Strategy


     Our business strategy combines the following elements:

   o Increase Sales in Research Models

   o Expand Biomedical Products and Services, which includes:

     --    Capitalizing on Outsourcing Trends within the Pharmaceutical
           Companies


                                        2


<PAGE>


     --    Building Upon Our Existing Capabilities

     --    Increasing Our Global Sales

   o Undertake Strategic Acquisitions and Alliances




<PAGE>

                                THE TRANSACTIONS

     We collectively refer to the recapitalization and the Sierra acquisition,
which we describe below, as the "Transactions."

The Recapitalization


     On September 29, 1999, we were acquired by certain affiliates of DLJ
Merchant Banking Partners II, L.P., management and other investors while certain
subsidiaries of Bausch & Lomb Incorporated retained a portion of their equity
investment in us, for total consideration of $456.2 million. As a result, DLJ
Merchant Banking Partners II, L.P. and some of its affiliates, whom we refer to
collectively as the "DLJMB Funds", indirectly own 71.9% and subsidiaries of
Bausch & Lomb Incorporated, whom we refer to collectively as the "Rollover
Shareholders", own 12.5% of Charles River Laboratories Holdings, Inc. We are a
wholly owned subsidiary of Charles River Laboratories Holdings, Inc., which does
not have any material operations or assets other than its ownership of all of
our capital stock. The financing of the recapitalization was with:

   o a portion of the proceeds from the offering of units, which consisted of
     the old notes and warrants to purchase shares of common stock of Charles
     River Laboratories Holdings


   o $105.6 million in equity investment, consisting of $92.4 million in cash by
     the DLJMB Funds, management, and other investors and equity retained by the
     Rollover Shareholders with a fair value of $13.2 million

   o a portion of the borrowings of approximately $162.0 million under our new
     senior secured credit facility


   o senior discount debentures with warrants issued by Charles River
     Laboratories Holdings to the DLJMB Funds and other investors for $37.6
     million

   o a subordinated discount note issued by Charles River Laboratories Holdings
     to the Rollover Shareholders for $43.0 million


   o We collectively refer to the Recapitalization and all related financing as
     the "Recapitalization."

The Sierra Acquisition


     Concurrently with the recapitalization, we acquired SBI Holdings, Inc.
("Sierra") for an initial total purchase price of $24.0 million, including
approximately $18.0 million in cash paid to the former shareholders and assumed
debt of approximately $6.0 million, which we immediately retired. The funding of
the acquisition of Sierra was with:


   o available cash

   o a portion of the net proceeds from the units

   o a portion of the borrowings under our new credit facility

                                       3

<PAGE>

     Sierra is a pre-clinical biomedical services company with expertise in drug
safety and efficacy assessment studies using research models. We believe that
the acquisition of Sierra will contribute to our growing presence in the
pre-clinical testing services business.

     We collectively refer to the acquisition of Sierra and all related
financings as the "Sierra Acquisition."

                                        4


<PAGE>
<PAGE>



                               THE EXCHANGE OFFER


Securities Offered......................   We are offering up to $150,000,000
                                           aggregate principal amount of 13 1/2%
                                           series B senior subordinated notes
                                           due 2009, which have been registered
                                           under the Securities Act. The terms
                                           of the new notes are identical in all
                                           material respects to the terms of the
                                           old notes, except that the new notes
                                           will only be guaranteed by CRL
                                           Transaction Company, Inc., a
                                           subsidiary of Charles River. The
                                           subsidiaries which guaranteed the old
                                           notes have been merged into Charles
                                           River. In addition, the new notes
                                           have been registered under the
                                           Securities Act and the transfer
                                           restrictions and registration rights
                                           relating to the old notes do not
                                           apply to the new notes.


                                           We are not offering to exchange the
                                           warrants that were issued with the
                                           old notes in this exchange offer. We
                                           are registering the warrants and the
                                           common stock into which the warrants
                                           are exercisable on a separate "shelf"
                                           registration statement.

The Exchange Offer......................   We are offering to issue the new
                                           notes in exchange for a like
                                           principal amount of your old notes.
                                           We are offering to issue the new
                                           notes to satisfy our obligations
                                           contained in the registration rights
                                           agreement entered into when the old
                                           notes were sold in transactions
                                           pursuant to Rule 144A and Regulation
                                           S under the Securities Act and
                                           therefore not registered with the
                                           SEC. For procedures for tendering,
                                           see "The Exchange Offer."


Expiration Date, Tenders, Withdrawal....   The exchange offer will expire at
                                           5:00 p.m. New York City time on
                                                                     , 2000
                                           unless it is extended. If you decide
                                           to exchange your old notes for new
                                           notes, you must acknowledge that you
                                           are not engaging in, and do not
                                           intend to engage in, a distribution
                                           of the new notes. If you decide to
                                           tender your old notes pursuant to the
                                           exchange offer, you may withdraw them
                                           at any time prior to , 2000. If we
                                           decide for any reason not to accept
                                           any old notes for exchange, your old
                                           notes will be returned to you without
                                           expense promptly after the exchange
                                           offer expires.


Federal Income Tax Consequences.........   Your exchange of old notes for new
                                           notes pursuant to the exchange offer
                                           will not result in any income, gain
                                           or loss to you for Federal income tax
                                           purposes. See "Material United States
                                           Federal Income Tax Consequences of
                                           the Exchange Offer."

Use of Proceeds.........................   We will not receive any proceeds from
                                           the issuance of the new notes
                                           pursuant to the exchange offer.


Exchange Agent..........................   State Street Bank and Trust Company
                                           is the exchange agent for the
                                           exchange offer. See page 110 for
                                           information on how to contact the
                                           exchange agent.


                                        5


<PAGE>



Accounting Treatment....................   We intend to account for the exchange
                                           offer based on the historical basis
                                           of accounting for the old notes. As a
                                           result, we will report the new notes
                                           at the same carrying value as the old
                                           notes on the date of the exchange.
                                           Accordingly, we will not recognize
                                           any gain or loss related to this
                                           exchange.

                                        6


<PAGE>



                      CONSEQUENCES OF EXCHANGING OLD NOTES
                         PURSUANT TO THE EXCHANGE OFFER

     Based on interpretations by the SEC's staff in no-action letters issued to
third parties, we believe that new notes issued in exchange for old notes
pursuant to the exchange offer may be offered for resale, resold or otherwise
transferred by you without registering the new notes under the Securities Act or
delivering a prospectus so long as each of the following applies to you:

     o     you are not one of our "affiliates", which is defined in Rule 405 of
           the Securities Act

     o     you acquire the new notes in the ordinary course of your business

     o     either you are a broker-dealer or you do not have any arrangement
           with any person to participate in the distribution of such new notes

     Unless you are a broker-dealer, you must acknowledge both that:

     o     you are not engaged in, and do not intend to engage in, a
           distribution of the new notes

     o     you have no arrangement or understanding to participate in a
           distribution of the new notes

     If you are an affiliate of Charles River, or you are engaged in, intend to
engage in or have any arrangement or understanding with respect to, the
distribution of new notes acquired in the exchange offer, you (1) should not
rely on our interpretations of the position of the SEC's staff and (2) must
comply with the registration and prospectus delivery requirements of the
Securities Act in connection with any resale transaction.

     If you are a broker-dealer and receive new notes for your own account
pursuant to the exchange offer:

     o    you must acknowledge that you will deliver a prospectus in connection
          with any resale of such new notes. The letter of transmittal states
          that by acknowledging and delivering a prospectus, you will not be
          deemed to admit that you are an "underwriter" within the meaning of
          the Securities Act

     o    you may use this prospectus, as it may be amended or supplemented from
          time to time, in connection with the resale of new notes received in
          exchange for old notes acquired by you as a result of market-making or
          other trading activities

     For a period of 90 days after the expiration of the exchange offer, we will
make this prospectus available to any broker-dealer for use in connection with
any such resale.

     In addition, you may offer or sell the new notes in some jurisdictions only
if they have been registered or qualified for sale there, or an exemption from
registration or qualification is available and is complied with. Subject to the
limitations specified in the registration rights agreement, we will register or
qualify the new notes for offer or sale under the securities laws of any
jurisdictions that you reasonably request in writing. Unless you request that
the sale of the new notes be registered or qualified in a jurisdiction, we
currently do not intend to register or qualify the sale of the new notes in any
jurisdiction. If you do not comply with such requirement, you could incur
liability under the Securities Act, and we will not indemnify you in such
circumstances.

                                        7


<PAGE>



                        SUMMARY DESCRIPTION OF THE NOTES


     The terms of the new notes and the old notes are identical in all material
respects, except that the new notes will only be guaranteed by CRL Transaction
Company, Inc., a subsidiary of Charles River. The subsidiaries which guaranteed
the old notes have been merged into Charles River. In addition, the new notes
have been registered under the Securities Act and the transfer restrictions and
registration rights relating to old notes do not apply to the new notes. We use
"notes" to refer to both the old notes and the new notes.


Maturity Date........................  October 1, 2009.

Interest Rate and Payment Dates......  Interest on the notes will accrue at the
                                       rate of 13.5% per year, payable
                                       semi-annually in cash in arrears on
                                       October 1 and April 1 of each year,
                                       commencing April 1, 2000. The interest
                                       rate is subject to increase to 14% per
                                       year on August 15, 2000 in the event we
                                       do not meet a specified ratio as of June
                                       30, 2000.

Optional Redemption..................  On or after October 1, 2004 we may redeem
                                       some or all of the notes at any time at
                                       the redemption prices described in the
                                       section "Description of Notes" under the
                                       heading

                                       Prior to October 1, 2002, we may redeem
                                       up to 35% of the notes with the proceeds
                                       of a public equity offering at the
                                       redemption price listed in the section
                                       "Description of Notes" under the heading
                                       "Optional Redemption."

Mandatory Repurchase Offer...........  If we sell certain assets or experience
                                       specific kinds of changes in control of
                                       our company, we must offer to repurchase
                                       the notes at the prices listed in the
                                       section "Description of Notes" under the
                                       heading "Repurchase at the Option of
                                       Holders." See "Risk Factors--We may be
                                       unable to purchase the notes upon a
                                       change of control."

Ranking..............................  The notes will be senior subordinated
                                       debt.

                                       The notes will rank:

                                       o  junior to all of our existing and
                                          future senior indebtedness and secured
                                          indebtedness, including any borrowings
                                          under our new credit facility

                                       o  equally with any of our future senior
                                          subordinated indebtedness, including
                                          trade payables

                                       o  senior to any of our future
                                          subordinated indebtedness

                                       o  effectively junior to all of the
                                          liabilities of our subsidiaries

                                       At September 25, 1999, on a pro forma
                                       basis, after giving effect to the
                                       Transactions, the notes would have been
                                       contractually subordinated to $163.3
                                       million of our senior indebtedness and
                                       effectively subordinated to $5.2 million

                                        8


<PAGE>



                                       of liabilities, including trade payables
                                       but excluding intercompany obligations,
                                       of our subsidiaries.

Certain Covenants....................  The indenture governing the notes
                                       contains certain covenants that limit,
                                       among other things, our ability, and the
                                       ability of some of our subsidiaries, to:

                                       o   borrow money

                                       o   create liens

                                       o   pay dividends on stock or repurchase
                                           stock

                                       o   make certain investments

                                       o   engage in transactions with
                                           affiliates or

                                       o   sell certain assets or merge with or
                                           into other companies

                                       For more details, see the section
                                       "Description of Notes" under the heading
                                       "Certain Covenants."

Use of Proceeds......................  We will not receive any proceeds from the
                                       exchange of new notes for old notes.

                                        9


<PAGE>



                   SUMMARY HISTORICAL AND UNAUDITED PRO FORMA
                           CONSOLIDATED FINANCIAL DATA


     The table below presents summary historical and unaudited pro forma
consolidated financial data and other data for Charles River. The summary
historical consolidated financial data for the fiscal years ended December 28,
1996, December 27, 1997 and December 26, 1998 are derived from our audited
consolidated financial statements and the notes thereto included elsewhere in
this prospectus. The summary unaudited financial data as of September 25, 1999
and for the nine months ended September 26, 1998 and September 25, 1999 are
derived from our unaudited consolidated financial statements and the notes to
those statements. In the opinion of management, our unaudited consolidated
financial statements include all adjustments, consisting only of normal
recurring adjustments, necessary for a fair presentation of the financial
condition and results of operations for these periods. The summary unaudited pro
forma consolidated financial data, which assume the Transactions had been
completed as of such dates, are derived from the Unaudited Pro Forma Condensed
Consolidated Financial Data appearing elsewhere in this prospectus. The summary
unaudited pro forma consolidated financial data do not purport to be indicative
of the results that actually would have been obtained had the Transactions been
completed as of such dates and are not intended to be a projection of our future
results of operations or financial position. You should read the information
contained in this table in conjunction with "Use of Proceeds," "Selected
Historical Consolidated Financial Data," "Management's Discussion and Analysis
of Financial Condition and Results of Operations," "Unaudited Pro Forma
Condensed Consolidated Financial Data" and our consolidated financial statements
and the notes thereto contained elsewhere in this prospectus.


<TABLE>
                                                                                                         Pro Forma
                                                                                                 ------------------------
                                                Fiscal Year (1)                9 Mos. Ended                     9 Mos.
                                          --------------------------------  --------------------- Fiscal Year   Ended
                                                                              Sept. 26,  Sept. 25,    Ended    Sept. 25,
                                             1996       1997       1998          1998       1999       1998     1999
                                          ---------   ---------  ---------    ---------  --------- ---------- --------
                                                                           (dollars in thousands)
<S>                                        <C>         <C>        <C>           <C>        <C>       <C>       <C>

Income Statement Data:
Net sales related to products...........   $146,477    $156,800   $169,377     $128,478   $139,269   $185,969  $155,303
Net sales related to services...........      9,127      13,913     23,924       17,041     21,827     23,924    21,827
                                           --------    --------   --------     --------   --------   --------  --------
Total net sales.........................    155,604     170,713    193,301      145,519    161,096    209,893   177,130
Cost of products sold...................     91,600     102,980    107,146       80,067     84,557    116,551    94,146
Cost of services provided...............      6,177       8,480     15,401       10,974     12,673     15,401    12,673
Selling, general and administrative
 expenses...............................     28,327      30,451     34,142       25,202     29,414     39,052    34,778
Amortization of goodwill and other
 intangibles............................        610         834      1,287        1,036      1,114      3,062     2,358
Restructuring charges...................      4,748       5,892         --           --         --         --        --
                                           --------    --------   --------     --------   --------   --------  --------
Operating income........................     24,142      22,076     35,325       28,240     33,338     35,827    33,175
Other Data:
EBITDA, as defined(2)...................    $33,670     $31,779    $46,220      $36,172    $42,039    $49,146   $43,660
Adjusted EBITDA(2)......................     39,167      38,528     47,234       37,012     43,378     50,642    45,450
Adjusted EBITDA margin..................      25.2%       22.6%      24.4%        25.4%      26.9%      24.1%     25.7%
Depreciation and amortization...........     $9,528      $9,703    $10,895       $7,932     $8,701    $13,611   $10,680
Capital expenditures....................     11,572      11,872     11,909        5,834      7,426     13,307     8,398
Cash interest expense(3).............................................................................  35,013    28,330
Cash flows from operating activities(4).    $20,545     $23,684    $36,699      $23,486    $19,552
Cash flows from investing activities(4).   $(11,678)   $(12,306)  $(22,349)    $(14,267)   $(4,751)
Cash flows from financing activities(4).    $(4,068)   $(12,939)   $(8,018)     $(2,412)  $(34,554)
Selected Ratios:
Ratio of earnings to fixed charges(5)...      18.8x       16.5x      25.8x        26.1x      33.7x       1.0x      1.2x
Ratio of Adjusted EBITDA to cash interest
    expense..........................................................................................    1.4x      1.6x
Ratio of total pro forma debt to Adjusted
    EBITDA.......................................................................................................  6.8x
</TABLE>
                                                       10



<PAGE>

<TABLE>

                                                    As of September 25, 1999
                                                    -------------------------
                                                    Historical    Pro Forma
                                                    ----------    ----------
                                                     (dollars in thousands)
<S>                                                          <C>           <C>

Balance Sheet Data:
Cash and cash equivalents..........................    $3,457        $3,678
Working capital....................................    20,596        32,001
Total assets.......................................   210,371       332,198
Total debt(6)......................................     1,033       311,128
Total stockholder's equity.........................   148,965       (30,357)
</TABLE>


- -------------------

(1)  Our fiscal year consists of twelve months ending on the Saturday closest to
     December 31.

(2)  EBITDA, as defined, represents operating income plus depreciation and
     amortization. EBITDA, as defined, is presented because it is a widely
     accepted financial indicator used by certain investors and analysts to
     analyze and compare companies on the basis of operating performance.

     Adjusted EBITDA, which represents EBITDA, as defined, adjusted for
     non-recurring, non-cash and cash items, as appropriate, is presented below
     because we believe it is a meaningful indicator of Charles River's
     operating performance and it is the measure by which certain of the
     covenants under the new credit facility are computed.

     EBITDA, as defined, and Adjusted EBITDA are not intended to represent cash
     flows for the period, nor are they presented as an alternative to operating
     income or as an indicator of operating performance. They should not be
     considered in isolation or as a substitute for measures of performance
     prepared in accordance with GAAP in the United States and are not
     indicative of operating income or cash flow from operations as determined
     under GAAP. Our method of computation may or may not be comparable to
     other similarly titled measures of other companies.

     The following table sets forth a reconciliation of EBITDA, as defined, to
     Adjusted EBITDA:

<TABLE>

                                                                                              Pro Forma
                                                                                     ------------------------
                                   Fiscal Year                Nine Months Ended                  9 Months
                              -----------------------------  -------------------                  Ended
                                                                                    Fiscal Year  Sept. 25,
                              1996       1997       1998      1998        1999      Ended 1998      1999
                              -----      -----     -----      -----      -----      -----------  ---------
                                                            (dollars in thousands)

<S>                                <C>        <C>       <C>        <C>         <C>        <C>        <C>

EBITDA, as defined.........    $33,670    $31,779   $46,220    $36,172     $42,039    $49,146    $43,660
Restructuring and other
   charges.................      4,748      5,892        --         --         400         --        400
Dividends received from
   equity investments......        725        773       681        681         815        681        815
Charles River non-cash
   compensation(a).........         24         84       333        159         124        333        124
Sierra non-cash
   compensation(a).........         --         --        --         --          --        262         --
Non-recurring transaction
   expenses(b).............         --         --        --         --          --        220        451
                               -------    -------   -------    -------     -------    -------    -------
Adjusted EBITDA............    $39,167    $38,528   $47,234    $37,012     $43,378    $50,642    $45,450
                               =======    =======   =======    =======     =======    =======    =======
</TABLE>


- -------------------

     (a)  Amount represents non-cash compensation expense recorded by Charles
          River and Sierra as a result of options under their respective option
          plans being issued at below fair market value.

    (b)   Represents expenses incurred by Sierra related to its acquisition of
          HTI Bio-Services, Inc., and to its acquisition by Charles River; these
          amounts are considered non-recurring.

(3)  Cash interest expense represents total interest expense less amortization
     of deferred financing costs and other non-cash interest charges.


(4)  Cash flows information is not presented with respect to the unaudited pro
     forma data because a statement of cash flows is not required by Article 11
     of SEC Regulation S-X.


(5)  For purposes of calculating the ratio of earnings to fixed charges,
     "earnings" consist of income before income taxes, minority interests and
     earnings from equity investments less minority interests plus earnings from
     equity investments plus fixed charges. "Fixed charges" consist of interest
     expense on all indebtedness, amortization of deferred financing costs and
     one-third of rental expense from operating leases that we believe is a
     reasonable approximation of the interest component of rental expense.

                                       11
<PAGE>

(6)  Total debt includes all debt and capital lease obligations, including
     current portions.

                                       12


<PAGE>



                                  RISK FACTORS

     In addition to the other matters described in this prospectus, you should
carefully consider the following risk factors before making an investment in the
new notes.

Risks relating to our debt


        We have a significant amount of debt, which could limit our growth and
our ability to respond to changing condition


     On a pro forma basis, after giving effect to the Transactions, as of
September 25, 1999, we had (a) total consolidated indebtedness of approximately
$311.1 million; and (b) approximately $28 million of borrowings available under
our new credit facility, subject to customary conditions. In addition, subject
to the restrictions in our new credit facility and the indenture, we may incur
significant additional indebtedness, which may be secured, from time to time.

     The level of our indebtedness could have important consequences, including:

   o limiting cash flow available for general corporate purposes, including
     acquisitions, because a substantial portion of our cash flow from
     operations must be dedicated to servicing our debt

   o limiting our ability to obtain additional debt financing in the future for
     working capital, capital expenditures or acquisitions

   o limiting our flexibility in reacting to competitive and other changes in
     our industry and economic conditions generally


     Though we currently have enough cash flow to service our debt, we may not
in the future and you may not receive interest or principal payments on the
notes


     Our ability to pay or to refinance our indebtedness will depend upon our
future operating performance, which will be affected by general economic,
financial, competitive, legislative, regulatory, business and other factors
beyond our control.

     We anticipate that our operating cash flow, together with money we can
borrow under our new credit facility, will be sufficient to meet anticipated
future operating expenses, to fund capital expenditures and to service our debt
as it becomes due. If we were still unable to meet our debt service obligations,
we could attempt to restructure or refinance our indebtedness or seek additional
equity capital. We cannot assure you that we will be able to accomplish those
actions on satisfactory terms, if at all.


     We may in the future incur significant additional indebtedness in order to
fund our working capital or capital expenditure needs, or to acquire other
businesses. If our cash flow were to decline, or our debt levels or interest
rates were to increase, the risks that we face in terms of our ability to
service debt could intensify and if we are unable to service our debt, you may
not receive interest or principal payments on the notes in a timely manner, or
at all.

   Restrictive covenants in our indenture and new credit facility may adversely
affect us by limiting the types of transactions we can enter into and
potentially leading to a default and an acceleration of our indebtedness.



     The indenture governing the notes contains various covenants that limit our
ability to engage in certain transactions.

     In addition, our new credit facility contains other and more restrictive
covenants and prohibits us from prepaying our subordinated indebtedness,
including the notes. Our new credit facility also requires us to maintain
specified financial ratios and satisfy certain other financial condition tests,
such as requiring us to maintain a

                                      13

<PAGE>

minimum EBITDA, minimum coverage of interest expense, minimum coverage of fixed
charges and a maximum leverage ratio. We are currently in compliance with such
ratios and tests; however, our ability to meet those financial ratios and tests
in the future can be affected by events beyond our control, and we cannot assure
you that we will meet those tests. A breach of any of these covenants could
result in a default under our new credit facility and/or the notes. Upon the
occurrence of an event of default under our new credit facility, which includes
a cross default to indebtedness of Charles River Laboratories Holdings, the
lenders could elect to declare all amounts outstanding under our new credit
facility to be immediately due and payable and terminate all commitments to
extend further credit. We pledged substantially all of our assets, other than
assets of our foreign subsidiaries, as security under our new credit facility.
If the lenders under our new credit facility accelerate the repayment of
borrowings, we may not have sufficient assets to repay our new credit facility
and our other indebtedness. If we were unable to repay amounts due under our new
credit facility, the lenders could proceed against the collateral granted to
them to secure that indebtedness.

The notes will be subordinated to other debt and holders of our senior debt must
be paid before you receive payment under the notes

   The notes will be subordinated to our senior indebtedness and holders of our
senior debt must be paid before you receive payment under the notes


     The notes rank junior to all of our existing and future senior
indebtedness, including all indebtedness under our new credit facility.

     As a result of the subordination of the notes, if:

     o we become insolvent or enter into a bankruptcy or similar proceeding

     o we fail to make a payment when due on senior indebtedness

     o any senior indebtedness is accelerated

then the holders of our senior indebtedness must be paid in full before you are
paid.

     In addition, we cannot make any cash payments to you if we have failed to
make payments to holders of designated senior indebtedness. Under certain
circumstances, we cannot make any payments to you for a period of up to 179 days
if we have defaulted, other than failures to make payments, under our senior
indebtedness covenants.

     At September 25, 1999, on a pro forma basis, after giving effect to the
Transactions, the notes would have ranked junior in right of payment to $163.3
million of senior indebtedness.


   We may incur additional indebtedness ranking equal to the notes and holders
of that debt would also receive proceeds from any dissolution of our company


     If we incur any additional debt that ranks equally with the notes
(including trade payables), the holders of that debt will be entitled to share
ratably with you in any proceeds distributed in connection with any insolvency,
liquidation, reorganization, dissolution or other winding-up of our company.
This may have the effect of reducing the amount of proceeds paid to you.


   The notes will be structurally junior to indebtedness of our subsidiaries
and the claims of those debt holders are senior to your claims


     Holders of indebtedness and other liabilities of our subsidiaries will
effectively be senior to your claims under the notes against those subsidiaries.
As of September 25, 1999, on a pro forma basis, our subsidiaries had $5.2
million of outstanding liabilities, including trade payables (excluding
intercompany obligations).

                                       14
<PAGE>


We may be unable to purchase the notes upon a change of control, which could
result in a default under the indenture


     Upon the occurrence of "change of control" events specified in the
"Description of Notes," you may require us to purchase your notes at 101% of
their principal amount, plus accrued interest. The terms of our new credit
facility limit our ability to purchase your notes in such circumstances. Any of
our future debt agreements may contain similar restrictions and provisions.
Accordingly, we may not be able to satisfy our obligations to purchase your
notes unless we are able to refinance or obtain waivers under the new credit
facility and other indebtedness with similar restrictions. We cannot assure you
that we will have the financial resources to purchase your notes,
particularly if such change of control event triggers a similar repurchase
requirement for, or results in the acceleration of, other indebtedness. Our new
credit facility currently provides that certain change of control events will
constitute a default and could result in the acceleration of our indebtedness
under the new credit facility.

Risks relating to our business

    Biosecurity breaches or "contaminations" can damage our inventory and result
in decrease in sales


     On a pro forma basis, research models accounted for 62% of our net sales
for the nine-month period ended September 25, 1999. We breed research models
that are free of certain agents, such as viruses and bacteria, which when
present can distort or otherwise compromise the quality of research results. We
also produce fertile chicken eggs that must be free of certain avian
contaminants in order to be used in poultry and human vaccine production. A
breach in biosecurity within any one of over 150 barrier breeding rooms or 50
poultry houses could result in the introduction of an otherwise excluded agent
into that room's animal or bird population. These breaches can arise from
several factors or conditions, including:


     o a supervisor's or animal care technician's failure to oversee or follow
       operating protocols,

     o compromised breed stock, or

     o from an erosion in a "clean room's" equipment or structure


     A biosecurity breach typically results in the "recycling" or cleaning up of
the contaminated room, which in turn results in inventory loss, clean-up and
start-up costs, and can reduce sales as a result of lost customer orders and
credits for prior shipments. Biosecurity breaches are unanticipated and
difficult to predict. We experienced several material contaminations in 1996 and
a few significant contaminations in 1997 that adversely impacted our 1996 and
1997 financial results. We experienced no significant contaminations in 1998.
Future contaminations may harm our reputation for providing high quality
products. In the event of a known contamination, we immediately notify our
customers. While avoidance of biosecurity breaches in our research model and SPF
egg facilities around the world is our highest operational priority, with
several worldwide programs in place, it is possible that we may
experience future barrier room or poultry house contaminations that will
adversely impact our operations and financial results.


   We are dependent on certain industries; consolidations in the pharmaceutical
industry may result in less demand for our business

     Our sales are highly dependent on research and development expenditures by
the pharmaceutical and, to a lesser extent, biotechnology industries. Our
operations could be materially and adversely affected by general economic
downturns in our clients' industries, or any decrease in research and
development expenditures.

     Over the past several years, the pharmaceutical industry has undergone a
period of significant consolidations, particularly in Europe, a trend that many
industry experts expect to continue. After recent consolidations, certain
customers combined or otherwise reduced their research and development
operations, resulting in fewer animal research activities. Due to these
consolidations, we have experienced both temporary disruptions and permanent
reductions in purchases of our research models by some of our customers.
Consolidations may also lead to reduced demand as our customers eliminate
redundant research activities. Future consolidations in the pharmaceutical

                                       15

<PAGE>

industry could result in additional disruptions and reductions in purchasing and
consequently adversely affect our results of operations.

   The outsourcing trend in the pharmaceutical industry may decrease, which
could affect our growth

     Some of our biomedical products and services businesses have grown
significantly as a result of the increase over the past several years in
outsourcing of non-clinical research support activities by pharmaceutical
companies. While industry analysts expect the outsourcing trend to continue for
the next several years, a substantial decrease in outsourcing activity in the
pre-clinical sector could result in a diminished growth rate in the sales of one
or more of our expected higher growth businesses.

   Displacement technologies may be developed, validated and increasingly used
in biomedical research, and as a result could reduce demand for some of our
products

     For many years, groups within the scientific and research community have
attempted to develop models, methods and systems that would replace or
supplement the use of living animals as test subjects in biomedical research.
While several techniques have been developed that have scientific merit,
especially in the area of cosmetics and household product testing (markets in
which we are not active), few alternative test methods have been validated and
successfully deployed in the discovery and development of effective and safe
treatments for human and animal disease conditions. The principal validated in
vitro or non-animal test system is the LAL, or endotoxin testing system, a
technology which we acquired and have aggressively marketed as an alternative to
an animal test. We are also part of a strategic alliance involving software that
is predictive of systemic responses to certain biologically active molecular
configurations. While we would expect to participate in some fashion with any in
vitro method as it becomes validated as a research model alternative or adjunct
in our markets, we cannot assure you that these methods will be available to us
or that we will be successful in commercializing these methods. Even if we are
successful, net sales from these methods may not offset reduced research model
net sales, which would adversely affect our results of operations.


     In our SPF egg business, researchers have developed recombinant
technologies that could displace certain avian vaccine applications for SPF
eggs. "Recombinant technologies" refers to technologies related to the
manipulation of DNA in a cell. At this time, we do not believe that these
technologies can compete with SPF eggs from a cost or performance standpoint,
but it is possible that recombinant technologies may improve in the future until
they become a commercially viable alternative to SPF eggs.

     In our endotoxin testing business, researchers are in the early stages of
developing a potential recombinant alternative to the naturally occurring LAL
product. We intend to collaborate with an academic research group with early
stage proprietary technology. While we do not expect the recombinant technology
to be a viable commercial alternative to LAL, due to cost and performance
deficiencies, it is possible that a technology displacement derived in vitro may
be developed.


     Such alternative research methods would decrease the need for research
models, and we may not be able to develop new products effectively or in a
timely manner to replace any lost sales.

   Animal rights issues could have a material adverse effect on our primate and
overall business


     Increased social focus on animal testing could adversely affect our
business. Although our primate business constitutes a small part of our overall
business, it has from time to time been subjected to animal rights media
attention and on-site protests, especially at our small import facility located
in England. In addition, animal rights activists have also focused on Sierra's
business, which involves large animals. Our core research models of rats, mice
and other rodents have not historically been the subject of such protests, but
may be in the future. Protests and demonstrations by animal rights activists may
lead our customers, many of whom are concerned with public perception, to decide
to decrease their business with us. In addition, threats to our facility located
in England have been made by animal rights activists, which may result in
property damages, or may cause us to incur expenses in protecting our employees
and our facility and subject us to liabilities.


                                       16
<PAGE>


   Some of our businesses are dependent on a few sources of animal suppliers and
supply and if we are unable to obtain resources from those suppliers, our
revenues may be adversely affected

     Our primate import business is dependent on animals both captured and bred
on the island of Mauritius. These animals are unique in that they are naturally
free of herpes B virus, which is important to our customers. While we have a
long-term supply agreement with the leading provider of these animals, and
supply has not been disrupted since we commenced importing these animals a
decade ago, it is possible that temporary or permanent obstacles to their
continued supply may arise, including export or import restrictions or embargos,
government or economic instability or severe weather conditions in Mauritius.
Sierra also depends on a supply agreement with a provider in China, and any
disruption of this supply may have a material adverse effect on its business.

     Our endotoxin testing business is dependent on the plentiful availability
of horseshoe crabs, the blood of which is used to produce the test material. It
is possible that there may be regulatory or other restrictions imposed on the
use of horseshoe crabs in the future.


     If we are not able to obtain these animals from our existing sources, we
may not be able to find an alternative source on commercially reasonable terms,
or delivery to our customers may be delayed.

   Our supply of animal feed may be interrupted by the bankruptcy of our
commercial supplier

     Our commercial supplier of animal feed for our United States research model
business has filed for reorganization under the U.S. Bankruptcy Code; however,
we do not expect this to interrupt our supply of animal feed. In addition, we
believe an alternative or secondary source of animal feed could be secured if
necessary on terms comparable with our current supplier, although we cannot
assure you that we will be able to secure an alternative or secondary source on
comparable commercial terms.

   Our operations in foreign countries are subject to risks


     Approximately 46%, 41%, 40% and 35% of our net sales for 1996, 1997, 1998
and the nine months ended September 25, 1999 were derived from our operations
outside the United States. In addition, approximately 35% of our pro forma net
sales for the nine-month period ended September 25, 1999 were derived from
operations outside the United States. Our operations and financial results could
be significantly affected by factors such as changes in foreign currency rates,
uncertainties related to regional economic circumstances and the costs of
complying with a wide variety of international and United States regulatory
requirements.

     Because the sales and expenses of our foreign operations are generally
denominated in local currencies, exchange rate fluctuations between local
currencies and the United States dollar will subject us to currency translation
risk with respect to the reported results of our foreign operations. These
fluctuations may have an adverse effect on our results of operations. We
currently do not hedge against the risk of exchange rate fluctuations.

   We face significant competition in our business and if we are unable to
respond to competition in our business, our revenues may be adversely affected

     We have different competitors in each of our business areas. We primarily
compete against smaller, limited-service providers in our research models
business and numerous other companies of varying sizes in our biomedical
products and services business. A few of our competitors in our biomedical
products and services business are larger than we are and may have greater
capital, technical and other resources than we do; however, many are smaller and
more regionalized. Of all of our businesses, we have the smallest relative share
in the biosafety testing market, where the market leader is a well established
company. Expansion by our competitors in other areas in which we operate could
affect our competitive position. We generally compete on the basis of quality,
reputation, and availability, which is supported by our international presence
with strategically located facilities. We cannot assure you that we will be able
to compete favorably in these areas in the future.


                                       17

<PAGE>


   We are dependent on key personnel and the loss of such personnel may
adversely affect our business

     Our success depends to a significant extent on the continued services of
our senior management and other members of management. James C. Foster, our
President, Chief Executive Officer and director, has been with Charles River for
over 23 years holding various positions, with him serving as our President and
Chief Executive since 1992. We have no employment agreement with Mr. Foster, nor
with any other named executive, and if Mr. Foster or other members of management
do not continue in their present positions, our business could be adversely
affected.



     Certain of our biomedical products and services businesses, most notably
the Special Animal Services and biosafety testing businesses, are particularly
dependent on the retention and recruitment of key personnel with highly
specialized technical backgrounds. We cannot assure you that we will be able to
continue to successfully recruit and retain key scientific staff necessary to
support superior levels of service in our higher growth businesses, especially
during a period of tight labor markets.

   If we are not successful in selecting and integrating the businesses we
acquire, we may be adversely affected

     Since December 31, 1996, we have completed four acquisitions and will
continue to review future acquisition opportunities in the ordinary course of
our business. We cannot assure you that acquisition candidates will continue to
be available on terms and conditions acceptable to us. Acquisitions involve
numerous risks, including, among other things, difficulties and expenses
incurred in connection with the acquisitions and subsequent assimilation of the
operations and services or products of the acquired companies, the difficulty of
operating new businesses, the diversion of management's attention from other
business concerns and the potential loss of key employees of the acquired
company. Acquisitions of foreign companies also may involve the additional risks
of assimilating differences in foreign business practices and overcoming
language barriers. In the event that the operations of an acquired business do
not live up to expectations, we may be required to restructure the acquired
business. We cannot assure you that our past and any future acquisitions,
including the Sierra Acquisition, will be successfully integrated into our
operations.

   We are controlled by our principal shareholders whose interests may differ
from your interests

     Circumstances may occur in which the interests of our principal
shareholders could be in conflict with your interests. In addition, these
shareholders may have an interest in pursuing transactions that, in their
judgment, enhance the value of their equity investment in our company, even
though such transactions may involve risks to you as a holder of the notes.

     Most of our outstanding shares of common stock are directly or indirectly
held by the DLJMB Funds. As a result of their stock ownership, the DLJMB Funds
control us and indirectly have the power to elect most of our directors, appoint
new management and approve any action requiring the approval of the holders of
common stock, including adopting amendments to our certificate of incorporation
and approving recapitalizations or sales of all or substantially all of our
assets. The directors elected by the DLJMB Funds will have the ability to
control decisions affecting our capital structure, including the issuance of
additional capital stock, the implementation of stock repurchase programs and
the declaration of dividends.

     The general partners of each of the DLJMB Funds are affiliates or employees
of Donaldson, Lufkin & Jenrette, Inc. Donaldson, Lufkin & Jenrette Securities
Corporation, which was the initial purchaser of the units, is an affiliate of
Donaldson, Lufkin & Jenrette, Inc., as is DLJ Capital Funding, Inc., which is
the lead arranger, syndication agent and a lender under our new credit facility.

   Our historical financial information may not be representative of our results
as a separate company

     The historical financial information we have included in this prospectus
may not reflect what our results of operations, financial position and cash
flows would have been had we been a separate, stand-alone company during the
periods presented or what our results of operations, financial position and cash
flows will be in the future.

                                       18

<PAGE>


Various adjustments and allocations were made to the historical financial
statements in this prospectus because Bausch &Lomb Incorporated did not account
for us as a single stand-alone business for all periods presented. We cannot
assure you that the adjustments and allocations we have made in preparing our
historical and pro forma consolidated financial statements appropriately reflect
our operations during the periods presented as if we had operated as a
stand-alone company.

We must comply with many federal, state and local rules and regulations which
could impose unanticipated costs, limit our flexibility in growing our business
and restrict our business opportunities

     Our business is affected by FDA regulations and similar foreign regulations
which may affect the demand for our products

     Our endotoxin testing business is regulated as a medical device
manufacturer under FDA regulations. We received a "warning letter" from the FDA
earlier last year, citing quality control and certain other operational
deficiencies at our Charleston, South Carolina facility which the agency
considered to be in violation of the laws or regulations enforced by the FDA.
While the FDA has allowed our operation to continue to manufacture and sell the
LAL product line produced at the Charleston facility, we must make certain
prescribed changes to our production and quality control systems in order to
maintain our license to manufacture at that facility. We expect that we will be
able to meet all of the FDA's requirements in the near future, and have already
made considerable progress in addressing the non-compliance issues, but we
cannot assure you that the FDA will conclude that our corrective actions are
adequate. If the FDA finds that we have not corrected the deficiencies noted in
the warning letter, the agency could, among other things, issue another warning
letter, request that we enter into a consent decree, prohibit new product
introductions, institute a product recall, prohibit us from shipping products
until all deficiencies are corrected to its satisfaction or temporarily revoke
our manufacturing license, any of which could have a material adverse effect on
our results of operations.

     Our business may be affected by changes in the Animal Welfare Act and
related regulations which may require us to alter our operations

     Certain of our business activities are currently regulated by the Animal
Welfare Act, which governs the treatment of certain animals intended for use in
research. Much of our United States small animal research model business, which
is predominantly rats and mice, is not subject to regulation under the Animal
Welfare Act although we comply with licensing and registration requirement
standards set by the USDA for handling animals, including breeding, maintenance
and transportation of our animals. Birds, including the chickens used in our
United States SPF egg business, are also not subject to Animal Welfare Act
regulations. However, the USDA, which enforces the Animal Welfare Act, is
presently considering changing the regulations issued pursuant to the Animal
Welfare Act, in light of judicial action, to include rats, mice and birds within
its coverage. The Animal Welfare Act imposes a wide variety of specific
regulations on producers and users of animal subjects, most notably cage size,
shipping conditions and environmental enrichment methods. Should the USDA decide
to include rats, mice and birds, especially chickens, in its regulations, we
could be required to alter our production operation for these models, including
adding production capacity, new equipment and additional employees. While we
believe that application of the Animal Welfare Act to our rats, mice and SPF egg
businesses in the United States will not result in loss of net sales, margin or
market share, since all producers and users will be subject to the same
regulations, we cannot assure you that the USDA's actions will not adversely
affect our operations. In addition, although we do not anticipate the addition
of rats, mice and birds to the Animal Welfare Act to require significant
expenditures, it is possible that the Animal Welfare Act, when amended, may be
more stringent than we expect and any future amendments to the Animal Welfare
Act or any other laws or regulations may require significant expenditures.


     In addition, some states have their own regulations, including general
anti-cruelty legislation, which establish certain standards in handling animals.
To the extent that we provide products and services overseas, we also have to
comply with foreign laws, such as the European Convention for the Protection of
Animals During International Transport and other anti-cruelty laws. The Council
of Europe is presently considering proposals to more stringently regulate animal
research.

                                       19


<PAGE>

     Noncompliance with such laws and regulations described above can result in
significant civil and criminal penalties.


   We have been engaged in legal disputes over environmental compliance at our
Florida Keys primate business for many years and may incur substantial costs to
resolve these disputes

     We have for two decades raised rhesus monkeys on two islands we purchased
for this purpose in the Florida Keys. Federal, state and local environmental and
wildlife authorities, as well as private environmental advocacy groups, have
challenged the continuing legality of this operation, citing damage to a
subsequently protected plant species, mangroves, resulting from the free range
conditions in which the primates have been maintained. To settle our disputes,
we have agreed to move the primates off the islands and thereafter transfer the
real property to the government. We have also agreed to refoliate the islands at
our cost, restoring them to their conditions prior to our arrival. While we
believe the refoliation process can be efficiently completed within a reasonable
period, we cannot assure you that the refoliation process will be successful, or
that there will not be any further disputes with environmental authorities
relating to this obligation in which restitution costs, damages and penalties
might be assessed.

   Healthcare reform could adversely affect our business


     The healthcare industry is subject to changing political, economic and
regulatory influences that may affect the pharmaceutical and biotechnology
industries. Adoption and implementation of government healthcare reform, most
notably price controls on new drugs, may adversely affect research and
development expenditures by pharmaceutical and biotechnology companies,
resulting in a decrease of the business opportunities available to us. Many
foreign governments have also reviewed or undertaken healthcare reform, and we
cannot predict the impact that any pending or future healthcare reform proposals
may have on our business in foreign countries.

Our business may be disrupted by year 2000 problems


     Prior to January 1, 2000, there was a great deal of concern regarding the
ability of computers to adequately recognize 21st century dates from 20th
century dates due to the two-digit date fields used by many systems. Most
reports to date, however, are that computer systems are functioning normally and
the compliance and remediation work accomplished during the years leading up to
2000 was effective to prevent any problems. We have not experienced any such
computer difficulty, however, computer experts have warned that there may still
be residual consequences of the change in centuries and any such difficulties
may, depending upon their pervasiveness and severity, have a material adverse
effect on our business, financial condition and results of operations.


If we cannot obtain consents and approvals from third parties required as a
result of the change in control of our company, we may be adversely affected


     A substantial number of our material agreements, including supply
agreements, license agreements, joint venture agreements and service agreements
contain provisions that require consents and/or approvals from third parties,
including government entities, in case of a change in control of our company. In
addition, a substantial number of our leases contain provisions prohibiting such
change in control or permitting the landlord to terminate the lease upon a
change in control. The Recapitalization constituted a change of control as
defined in those agreements. We have received the necessary consents and/or
approvals from third parties to our material agreements, except those from
government entities. Consents from government entities generally require
post-transaction disclosure which is in process, and we expect to receive such
consents. We cannot assure you that all consents and/or approvals that are
triggered by the change in control of our company will be obtained from
government entities. Our inability to obtain such consents may have a material
adverse effect on our business.


                                       20


<PAGE>


Fraudulent transfer statutes may limit your rights as a noteholder

     Federal or state fraudulent transfer laws permit a court, if it makes
certain findings, to

     o avoid all or a portion of our obligations to you;

     o subordinate our obligations to you to our other existing and future
       indebtedness, entitling other creditors to be paid in full before any
       payment is made on the notes; and

     o take other action detrimental to you, including, in certain
       circumstances, invalidating the notes.

     If a court were to take any of these actions, we cannot assure you that you
would ever be repaid on the notes. Moreover, if the payments to certain of our
stockholders made pursuant to the recapitalization agreement with the proceeds
of the notes were determined to have violated the financial requirements in the
Delaware corporations statute, you will not be entitled under such law to
recover these payments from either the stockholders or the members of our board
of directors that authorized these payments.

     Under federal and state fraudulent transfer laws, in order to take any of
these actions, courts will typically need to find that, at the time the notes
were issued, we:

     (1)   issued the notes with the intent of hindering, delaying or defrauding
current or future creditors; or

     (2) received less than fair consideration or reasonably equivalent value
for incurring the indebtedness represented by the notes and

     (a)   were insolvent or were rendered insolvent by reason of the issuance
  of the notes;

     (b) were engaged, or about to engage, in a business or transaction for
  which our assets were unreasonably small; or

     (c) intended to incur, or believed (or should have believed) we would
  incur, debts beyond our ability to pay as such debts mature (as all of the
  foregoing terms are defined in or interpreted under such fraudulent transfer
  statutes).


     Different jurisdictions define "insolvency" differently. However, we
generally would be considered insolvent at the time we incurred the indebtedness
constituting the notes if (1) the fair market value (or fair saleable value) of
our assets is less than the amount required to pay our total existing debts and
liabilities (including the probable liability related to contingent liabilities)
as they become absolute or matured or (2) we were incurring debts beyond our
ability to pay as such debts mature. We cannot assure you as to what standard a
court would apply in order to determine whether we were "insolvent" as of the
date the notes were issued, and it is possible that, regardless of the method of
valuation, a court may determine that we were insolvent on that date. Also, a
court may determine, regardless of whether we were insolvent on the date the
notes were issued, that the payments constituted fraudulent transfers on another
ground.

There are no public trading markets for the notes which may limit your ability
to sell your notes


     The notes are a new issue of securities for which there is currently no
active trading markets. If any of the notes are traded after they are initially
issued, they may trade at a discount from their initial offering price. The
trading price of the notes depends on prevailing interest rates, the market for
similar securities and other factors, including economic conditions and our
financial condition, performance and prospects.

                                       21


<PAGE>


                           FORWARD-LOOKING STATEMENTS

     This prospectus includes "forward-looking statements" including, in
particular, the statements about our plans, strategies and prospects under the
headings "Summary," "Management's Discussion and Analysis of Financial Condition
and Results of Operations" and "Business," and in the Unaudited Pro Forma
Financial Information and the related notes. Although we believe that our plans,
intentions and expectations reflected in or suggested by such forward-looking
statements are reasonable, we can give no assurance that such plans, intentions
or expectations will be achieved. Important factors that could cause actual
results to differ materially from the forward-looking statements we make in this
prospectus are set forth in this prospectus, including under the headings "Risk
Factors," "Management's Discussion and Analysis of Financial Condition and
Results of Operations" and "Business." All forward looking statements
attributable to us or persons acting on our behalf are expressly qualified in
their entirety by the cautionary statements and risk factors contained
throughout this prospectus.

                            INDUSTRY AND MARKET DATA

     In this prospectus, we rely on and refer to information and statistics
regarding the research model and biomedical products and services industries,
and our market share in the sectors in which we compete. We obtained this
information and statistics from various third party sources, discussions with
our customers and/or our own internal estimates. We believe that these sources
and estimates are reliable, but we have not independently verified them.


                                THE TRANSACTIONS

The Recapitalization


     We entered into a recapitalization agreement dated as of July 25, 1999 with
Bausch & Lomb Incorporated ("B&L"), the Rollover Shareholders, Charles River
Laboratories Holdings, DLJMB and CRL Acquisition LLC, a wholly owned subsidiary
of DLJMB. The recapitalization agreement provided for, among other things:


   o the contribution of all assets and liabilities (except as described below)
     relating to our business by the Rollover Shareholders to us in exchange for
     all of our capital stock


   o the exchange by the Rollover Shareholders of their shares of our capital
     stock for an equivalent ownership of shares of Charles River Laboratories
     Holdings, so that Charles River Laboratories Holdings will own 100% of our
     capital stock

   o the Rollover Shareholders retaining certain assets including:


      o   substantially all of our cash and cash equivalents as of the day
          preceding the closing date

      o   all receivables owed by the Rollover Shareholders or their affiliates


   o the Rollover Shareholders retaining certain liabilities including:


      o   all indebtedness for borrowed money outstanding immediately prior to
          the closing date

      o   all payables and other obligations owed to the Rollover Shareholders
          or any of their affiliates

      o   all tax liabilities relating to pre-closing periods

   o the formation by CRL Acquisition LLC of a wholly owned subsidiary
     ("Acquisition Subco"). CRL Acquisition LLC and Acquisition Subco were
     organized by DLJMB for the purpose of consummating the

                                       22

<PAGE>

     Recapitalization. The DLJMB Funds, management and other investors who
     previously purchased units contributed equity of $92.4 million in cash to
     CRL Acquisition LLC in exchange for all of the membership interests in CRL
     Acquisition LLC, and CRL Acquisition LLC then contributed equity of $92.4
     million in cash to Acquisition Subco in exchange for all of the capital
     stock of Acquisition Subco


   o the merger of Acquisition Subco with and into Charles River Laboratories
     Holdings, with Charles River Laboratories Holdings being the surviving
     entity

   o the redemption by Charles River Laboratories Holdings of 87.5% of its
     capital stock from the Rollover Shareholders for $400.0 million in cash and
     a subordinated discount note for $43.0 million issued by Charles River
     Laboratories Holdings to the Rollover Shareholders; the Rollover
     Shareholders retained 12.5% of their equity investment with a fair market
     value of $13.2 million

     As a result of the Recapitalization, the DLJMB Funds, management and
certain other investors indirectly own (through CRL Acquisition LLC) 87.5% of
the capital stock of Charles River Laboratories Holdings and the Rollover
Shareholders own 12.5% of the capital stock of Charles River Laboratories
Holdings.


The Sierra Acquisition


     We acquired Sierra for an initial total purchase price of $24.0 million,
including approximately $18.0 million in cash paid to former shareholders and
assumed debt of approximately $6.0 million, which we immediately retired. In
addition, we have obligations to pay:


   o up to $2.0 million in contingent purchase price if certain financial
     objectives are reached by December 31, 2000

   o up to $10.0 million in performance-based bonus payments if certain
     financial objectives are reached over the next five years, with no payment
     in any individual year to exceed $2.7 million

   o $3.0 million in retention and non-competition payments contingent upon the
     continuing employment of certain key scientific and management personnel
     through June 30, 2001

The Financing

     We consummated the Recapitalization and the Sierra Acquisition concurrently
(the "effective time"). In order to fund the consideration for the Transactions
and pay related fees and expenses:

   o we issued and sold units pursuant to an offering memorandum in the
     aggregate principal amount of $150.0 million

   o we obtained $105.6 million in equity investment, consisting of $92.4
     million in cash by the DLJMB Funds, management, and other investors and
     equity retained by the Rollover Shareholders with a fair value of $13.2
     million

   o we entered into a new $190.0 million senior secured credit facility,
     consisting of $160.0 million of term loan availability and $30.0 million of
     revolving loan availability with a group of financial institutions led by
     DLJ Capital Funding. At the effective time, we borrowed all of the term
     loans and $2.0 million of the revolving credit facility. We may use the
     remaining borrowing availability under the new credit facility for general
     corporate purposes, subject to certain conditions, including the absence of
     any material adverse change


   o Charles River Laboratories Holdings issued senior discount debentures with
     warrants to the DLJMB Funds and other investors for $37.6 million


                                       23

<PAGE>

   o Charles River Laboratories Holdings issued a subordinated discount note to
     the Rollover Shareholders for $43.0 million

     Concurrently with the effective time:


   o we dividended $270.0 million less fees and expenses, which included a
     portion of the amount received pursuant to the units previously offered and
     under our new credit facility, to Charles River Laboratories Holdings

   o the Rollover Shareholders received cash in the amount of $400.0 million and
     a subordinated discount note for $43.0 million in exchange for 87.5% of
     their shares of capital stock of Charles River Laboratories Holdings; the
     Rollover Shareholders retained 12.5% of their equity investment with a fair
     market value of $13.2 million

     The funding of the Sierra Acquisition was with:


   o available cash

   o a portion of the net proceeds from the units

   o a portion of the borrowings under our new credit facility

                                       24


<PAGE>



     The following table sets forth the sources and uses of funds for the
Transactions on a pro forma basis.

<TABLE>

                                                                            As of September
                                                                               25, 1999
                                                                            ---------------
                                                                              (dollars in
                                                                              thousands)
<S>                                                                                <C>
Sources:
Available cash.............................................................   $  2,508
Borrowings under our new credit facility:
Revolving credit facility(1)...............................................      2,000
Term loans(2)..............................................................    160,000
Units(3)...................................................................    150,000
Senior discount debentures with warrants of Holdings(4)....................     37,613
Subordinated discount note of Holdings(5)..................................     43,000
Equity investment by DLJMB Funds, management and other investors...........     92,387
Rollover Shareholders' equity..............................................     13,198
                                                                              --------
   Total sources...........................................................   $500,706
                                                                              ========
Uses:
Recapitalization consideration.............................................   $443,000
Sierra acquisition consideration(6)........................................     24,000
Rollover Shareholders' equity..............................................     13,198
Debt issuance costs........................................................     13,237
Loans to management........................................................        920
Transaction fees and expenses(7)...........................................      6,351
                                                                              --------
   Total uses..............................................................   $500,706
                                                                              ========
</TABLE>

- -------------------

(1)  We have availability of $28.0 million under our new revolving credit
     facility, subject to customary borrowing conditions. See "Description of
     New Credit Facility."

(2)  Includes a senior secured Term Loan A facility of $40.0 million and a
     senior secured Term Loan B facility of $120.0 million.


(3)  Represents the issuance of $150.0 million of units previously offered which
     was allocated between senior subordinated notes ($147.9 million) and the
     warrants ($2.1 million).

(4)  Investment by the DLJMB Funds in Charles River Laboratories Holdings, Inc.

(5)  Investment by the Rollover Shareholders in Charles River Laboratories
     Holdings, Inc.

(6)  The total Sierra acquisition consideration of $24.0 million was used to pay
     existing shareholders (approximately $18.0 million) and to retire Sierra's
     existing debt (approximately $6.0 million).


(7)  Includes financial advisory and other fees, and legal, accounting and other
     professional fees. See "Certain Relationships and Related Transactions."

                                       25


<PAGE>



                                 USE OF PROCEEDS


     Our net proceeds from the offering of the units, after deducting the
expenses of the Transactions, including discounts and commissions to the initial
purchaser, were approximately $143.2 million. We dividended $270.0 million less
certain fees and expenses, consisting of a portion of the net proceeds from the
offering together with a portion of the $162.0 million of initial borrowings
under our new credit facility to Charles River Laboratories Holdings. Holdings
used the proceeds from this dividend, together with its new equity investment by
the DLJMB Funds, management and other investors, proceeds from the issuance of
its senior discount debentures with warrants and its subordinated discount note,
to fund the Recapitalization and to pay certain fees and expenses related to the
Recapitalization. We used the remaining proceeds to fund the Sierra Acquisition
and pay certain related fees and expenses. See "The Transactions." We will not
receive any proceeds from the issuance of the new notes.


                                       26


<PAGE>



                                 CAPITALIZATION

     The following table presents Charles River's consolidated cash and cash
equivalents and capitalization as of September 25, 1999 (i) on a historical
basis and (ii) as adjusted to give pro forma effect to the Transactions. This
table should be read in conjunction with "The Transactions," "Use of Proceeds,"
"Management's Discussion and Analysis of Financial Condition and Results of
Operations," our consolidated financial statements and notes thereto included
elsewhere in this prospectus. See "Unaudited Pro Forma Condensed Consolidated
Financial Data."

     <TABLE>
                                                                                    As of September 25, 1999
                                                                                   -------------------------
                                                                                    Historical    Pro Forma
                                                                                    ----------    ---------
                                                                                     (dollars in thousands)
<S>
                                                                                          <C>          <C>

Debt:
New credit facility(1):
   Revolving credit facility......................................................      $     --       $2,000
   Term loans(2)..................................................................            --      160,000
Senior subordinated notes(3)......................................................            --      147,872
Capital lease obligations and other long-term debt................................         1,033        1,256
                                                                                        --------     --------
      Total debt..................................................................         1,033      311,128
                                                                                        --------     --------
Shareholder's equity:
   Common stock...................................................................             1            1
   Additional paid-in capital.....................................................        17,836      105,896
   Retained earnings..............................................................       142,422     (124,040)
   Loans to officers..............................................................            --         (920)
   Accumulated other comprehensive income.........................................       (11,294)     (11,294)
                                                                                        --------     --------
      Total shareholder's equity..................................................       148,965      (30,357)
                                                                                        --------     --------
      Total capitalization........................................................      $149,998     $280,771
                                                                                        ========     ========
</TABLE>


- -------------------


(1)  We have availability of $28.0 million under our new revolving credit
     facility, subject to customary borrowing conditions. See "Description of
     New Credit Facility."


(2)  Includes a senior secured Term Loan A facility of $40.0 million and a
     senior secured Term Loan B facility of $120.0 million.


(3)  Represents the offering proceeds of $150.0 million related to the units
     which was allocated between the senior subordinated notes ($147.9 million)
     and the warrants ($2.1 million).



                                       27


<PAGE>



                 SELECTED HISTORICAL CONSOLIDATED FINANCIAL DATA


     The following table presents Charles River's selected historical
consolidated financial data and other data as of and for the fiscal years ended
December 31, 1994, December 30, 1995, December 28, 1996, December 27, 1997 and
December 26, 1998 and as of and for the nine months ended September 26, 1998 and
September 25, 1999. The selected historical consolidated financial data as of
and for the three fiscal years ended December 26, 1998 are derived from our
audited consolidated financial statements and the notes to those statements. The
selected historical consolidated financial data as of and for the fiscal years
ended December 31, 1994 and December 30, 1995 and as of and for the periods
ended September 26, 1998 and September 25, 1999 were derived from our unaudited
consolidated financial statements and the notes to those statements. In the
opinion of management, our unaudited consolidated financial statements include
all adjustments, consisting only of normal recurring adjustments, necessary for
a fair presentation of the financial condition and results of operations for
these periods. The information contained in this table should be read in
conjunction with "Management's Discussion and Analysis of Financial Condition
and Results of Operations" and our consolidated financial statements and the
notes thereto contained elsewhere in this prospectus.


     <TABLE>

                                                          Fiscal Year(1)                          Nine Months Ended
                                     ------------------------------------------------------     ---------------------
                                                                                                September   September
                                       1994        1995        1996        1997        1998      26, 1998    25, 1999
                                      ------      ------     -------      ------      ------    ---------   ---------
                                                                  (dollars in thousands)

<S>                                  <C>         <C>         <C>         <C>         <C>         <C>         <C>
Income Statement Data:

   Net sales related to products...  $128,890    $133,514    $146,477    $156,800    $169,377    $128,478    $139,269
   Net sales related to services...     6,857       7,527       9,127      13,913      23,924      17,041      21,827
                                    ---------    --------    --------    --------    --------    --------    --------
   Total net sales.................   135,747     141,041     155,604     170,713     193,301     145,519     161,096
   Cost of products sold...........    78,235      78,877      91,600     102,980     107,146      80,067      84,557
   Cost of services provided.......     6,857       7,527       6,177       8,480      15,401      10,974      12,673
   Selling, general and
      administrative expenses......    25,824      27,976      28,327      30,451      34,142      25,202      29,414
   Amortization of goodwill and
      other intangibles............       437         558         610         834       1,287       1,036       1,114
   Restructuring charges...........     4,788          --       4,748       5,892          --          --          --
                                      -------     -------     -------     -------     -------     -------     -------
   Operating income................    19,606      26,103      24,142      22,076      35,325      28,240      33,338
        Other income...............        --          --          --          --          --          --       1,441
   Interest income.................       149         634         654         865         986         659         496
   Interest expense................      (464)       (768)       (491)       (501)       (421)       (311)       (207)
   Gain/(loss) from foreign
      currency, net................        39         (68)         84        (221)        (58)       (127)       (143)
                                      -------     -------     -------     -------     -------     -------     -------
   Income before income taxes,
      minority interests and
      earnings from equity
      investments..................    19,330      25,901      24,389      22,219      35,832      28,461      34,925
   Provision for income taxes......     7,995      10,759      10,889       8,499      14,123      11,280      16,903
                                      -------     -------     -------     -------     -------     -------     -------
   Income before minority
      interests and earnings from
      equity investments...........    11,335      15,142      13,500      13,720      21,709      17,181      18,022
   Minority interests..............        --         (13)         (5)        (10)        (10)         (8)        (10)
   Earnings from equity
      investments..................     1,492       1,885       1,750       1,630       1,679       1,286       1,940
                                      -------     -------     -------     -------     -------     -------     -------
   Net income......................   $12,827     $17,014     $15,245     $15,340     $23,378     $18,459     $19,952
                                      =======     =======     =======     =======     =======     =======     =======
Other Data:
   Depreciation and
      amortization.................    $9,635      $9,717      $9,528      $9,703     $10,895      $7,932      $8,701
   Capital expenditures............     5,727      10,239      11,572      11,872      11,909       5,834       7,426
</TABLE>

                                       28


<PAGE>
<TABLE>
                                                          Fiscal Year(1)                          Nine Months Ended
                                     ------------------------------------------------------     ---------------------
                                                                                                September   September
                                       1994        1995        1996        1997        1998      26, 1998    25, 1999
                                      ------      ------     -------      ------      ------    ---------   ---------
                                                                  (dollars in thousands)

<S>                                  <C>         <C>         <C>         <C>         <C>         <C>         <C>

   Ratio of earnings to fixed
      charges(2)...................     21.9x       18.9x       18.8x       16.5x       25.8x       26.1x       33.7x
   Balance Sheet Data (at end
      of period):
   Cash and cash equivalents.......    $9,584     $15,336     $19,657     $17,915     $24,811     $25,184      $3,457
   Working capital.................    23,366      35,901      45,204      41,746      37,422      48,457      20,596
   Total assets....................   164,680     184,271     196,981     196,211     233,410     222,092     210,371
   Total debt(3)...................     4,142       4,626       1,645       1,363       1,582       1,462       1,033
   Total shareholder's equity......   126,000     142,212     153,818     149,364     168,259     165,324     148,965
      </TABLE>

- -------------------

(1)  Our fiscal year consists of twelve months ending on the Saturday closest to
     December 31.

(2)  For purposes of computing the ratio of earnings to fixed charges,
     "earnings" consist of income before income taxes, minority interests and
     earnings from equity investments less minority interests plus earnings from
     equity investments plus fixed charges. "Fixed charges" consist of interest
     expense on all indebtedness, amortization of deferred financing costs and
     one-third of rental expense from operating leases that we believe is a
     reasonable approximation of the interest component of rental expense.

(3)  Total debt includes all debt and capital lease obligations, including
     current portions.

                                       29


<PAGE>



                     MANAGEMENT'S DISCUSSION AND ANALYSIS OF
                  FINANCIAL CONDITION AND RESULTS OF OPERATIONS

     The following discussion should be read in conjunction with our
consolidated financial statements and our unaudited pro forma condensed
consolidated financial statements, including the notes thereto, included
elsewhere in this prospectus.

     This discussion contains forward-looking statements which involve risks and
uncertainties. Our actual results may differ significantly from the results
discussed in the forward-looking statements. Factors that might cause such
differences include, but are not limited to, those discussed in "Risk Factors."


                                  CHARLES RIVER

Overview


     We are a global market leader in the commercial production and supply of
animal research models for use in the discovery, development and testing of new
pharmaceuticals. The expansion of our core capabilities in research models has
enabled us to become a leading supplier of related biomedical products and
services in several specialized niche markets. Our research model capabilities
and biomedical products and services, together with our global distribution
network, allow us to meet the extensive needs of our broad customer base. Our
customers consist primarily of large pharmaceutical companies, including the ten
largest global pharmaceutical companies based on 1998 revenues, as well as
biotechnology, animal health, medical device and diagnostic companies and
hospitals, academic institutions and government agencies. Our facilities are
located in 18 countries, including the United States, Canada, Japan and many
European countries.

     We operate in two segments for financial reporting purposes--research
models and biomedical products and services. On a pro forma basis, research
models accounted for 62%, and biomedical products and services accounted for
38%, of net sales for the nine-month period ended September 25, 1999. Over the
same period, we reported pro forma net sales of $177.1 million and pro forma
Adjusted EBITDA of $45.4 million. Adjusted EBITDA represents EBITDA, as defined,
adjusted for non-recurring, non-cash and cash items, as appropriate, which are
more fully described on page 12. EBITDA, as defined, represents operating income
plus depreciation and amortization. We present Adjusted EBITDA because we
believe it is a meaningful indicator of Charles River's operating performance,
and it is the measure by which certain of the covenants under the new credit
facility are computed. EBITDA, as defined, and Adjusted EBITDA are not intended
to represent cash flows for the period, nor are they presented as an alternative
to operating income or as an indicator of operating performance. They should not
be considered in isolation or as a substitute for measures of performance
prepared in accordance with GAAP in the United States and are not indicative of
operating income or cash flow from operations as determined under GAAP. Our
method of computation may not be comparable to other similarly titled measures
of other companies.


     Sierra, which we recently acquired, is a pre-clinical biomedical services
company with expertise in drug safety and efficacy assessment studies using
research models. Sierra offers its services to biotechnology, pharmaceutical and
medical device companies that are principally focused on conducting studies
needed in the early stages of drug development, especially those that require
highly specialized scientific capabilities. Sierra has expertise in conducting
critical developmental studies on potential new drugs and devices using research
models, including short-term evaluations of potential new treatment for human or
animal disease conditions.

     Net Sales. We recognize net sales when a product is shipped or as services
are rendered. Over the past three years, unit volume of small animal research
models has increased modestly in North America and has decreased modestly in
Europe. During the same period, sales in both North America and Europe have
increased, principally as a result of price increases and a shift in mix towards
higher priced research models. In recent years, we have increased our focus on
the sale of specialty research models, such as special disease models, which
have contributed to additional sales growth.

                                       30


<PAGE>



     Our customers typically place orders for research models with less than a
week's lead time. Meeting such demand requires efficient inventory management
and strong customer service support. We improved inventory availability in the
last two years through better forecasting and production mix, and most
importantly, improved biosecurity, thereby reducing the possibility of
contaminations.

     Biomedical products and services have grown at a compounded rate of 31%
from 1996 to 1998 and accounted for 30% of our sales in 1998, compared to 22% in
1996. Our growth in this business demonstrates our ability to capitalize on our
core research model technology and enter into related product development
activities undertaken by our customers.

     Pricing. We maintain published list prices for all of our research models,
biomedical products and certain of our services. We also have pricing agreements
with our customers which provide certain discounts, usually based on volume.
Many of our services are based on customized orders and are priced accordingly.
While pricing has been competitive, certain of our products are priced at a
premium due to the higher quality, better availability, and superior customer
support that our customers associate with our products.

     Biosecurity. Biosecurity is our highest operational priority. Prior
breaches of biosecurity have adversely affected our results of operations, and
we cannot assure you that future breaches would not materially affect our
results of operations. A biosecurity breach typically results in additional
expenses from the need to "recycle" or clean up the contaminated room, which in
turn results in inventory loss, clean-up and start-up costs, and can reduce net
sales as a result of lost customer orders and credits for prior shipments. We
experienced several significant contaminations in 1996 and a few significant
contaminations in 1997, both in our barrier rooms for research models and in our
poultry houses for SPF eggs. As a result, our net sales in 1996 and 1997 were
adversely affected by our inability to fulfill customer orders and our expenses
were increased during those periods by the costs associated with cleaning up the
contaminations. Since December 31, 1996, we have made over $6.0 million of
capital expenditures designed to strengthen our biosecurity, primarily by
upgrading our production facilities. In addition, we have made significant
changes to our operating procedures for barrier rooms and poultry houses
designed to further minimize the risks of contamination, including, for example,
increasing the frequency of replacing masks and gowns, and most importantly,
increasing awareness and training among our employees. These improvements to our
operating procedures increased annual ongoing biosecurity related expenses by
approximately $0.5 million in 1998. While we cannot assure you that we will not
experience future significant barrier room or poultry house contaminations in
the future, these changes have contributed to our absence of significant
contaminations during 1998 and the first nine months of 1999.


     Acquisitions. Since December 31, 1996, we have successfully acquired and
integrated four companies, which contributed $6.3 million in sales in 1998, or
3.3% of total sales. We acquired Sierra for an initial total purchase price of
$24.0 million, including approximately $18.0 million in cash paid to former
shareholders and assumed debt of approximately $6.0 million, which we
immediately retired. In addition, we have agreed to pay (a) up to $2.0 million
in contingent purchase price if certain financial objectives are reached by
December 31, 2000, (b) up to $10.0 million in performance-based bonus payments
if certain financial objectives are reached over the next five years, with no
payment in any individual year to exceed $2.7 million, and (c) $3.0 million in
retention and non-competition payments contingent upon the continuing employment
of certain key scientific and managerial personnel through June 30, 2001.


     The $2.0 million in contingent purchase price will, if paid, increase
goodwill and/or other identifiable intangibles by the same amount and not affect
our results of operations except through the subsequent related amortization
expense and any interest expense related to any borrowings necessary to finance
such payment. The $10.0 million in performance-based bonus payments, will, if
paid, be expensed during the period in which it becomes reasonably certain that
such financial objectives will be achieved. The $3.0 million in retention and
non-competition payments will be expensed over the next two years. The
contingent purchase price and performance-based bonus payments are not reflected
in the pro forma financial data included elsewhere herein because they are not
considered reasonably estimable; the retention and non-competition payments are
not included in the pro forma financial data as they are considered
non-recurring.

     Joint Ventures. We have two unconsolidated joint ventures which are
accounted for under the equity method. Our largest is Charles River Japan, which
we own 50%/50% with Ajinimoto Co., Inc., and is an extension of our research
model business. Our royalty agreement provides us with 3% of the sales of
locally produced research models. We also receive dividends based on our
pro-rata share of 50% of net income. Dividends received from Charles River Japan
were

                                       31
<PAGE>

$0.7 million, $0.8 million and $0.7 million in 1996, 1997 and 1998,
respectively. In addition, dividends for 1999 in the amount of $0.8 million have
been received. Our other unconsolidated joint venture is Charles River Mexico,
an extension of our SPF eggs business, which is not significant to our
operations.


     Restructuring Program. During 1996 and 1997, we implemented two
restructuring programs. Our plans, which were submitted to and approved by B&L,
were designed to reduce excess capacity, increase efficiencies, eliminate
nonessential operating and staff personnel, and close several small
product-lines.

      In 1996, we established a restructuring reserve in the amount of $4.7
million, based on our plan to close certain animal facilities in the U.S.,
eliminate personnel in U.S., Europe and elsewhere, and close an animal facility
in Germany. These were areas in our business where due to excess capacity or
staff, financial performance was below expectations. These actions, which were
completed in 1996, had the impact of reducing cost of products sold and services
provided and selling, general and administrative expenses. These initiatives
contributed to improved profitability by eliminating costs, and improving
operating efficiencies in all areas targeted. When we prepared our restructuring
program, we estimated we would save approximately $2.6 million on an annual
basis. While we were successful in reducing our headcount, closing the small
product lines and reducing our excess capacity, we did not achieve all of the
efficiencies we had hoped for and our savings were somewhat less than planned.
After 1997, we have not continued to track expense savings, in part because the
continuous evolution and changes that take place in our business make this
difficult, and in addition, the value of monitoring the savings diminishes over
time.

     In 1997, we established a restructuring reserve in the amount of $5.9
million, based on our plan to close certain facilities and eliminate personnel
in our SPF egg business, eliminate personnel in Europe, reduce corporate staff,
and relocate our primate colony. The actions underlying this plan have been
completed and had the impact of reducing cost of products sold and services
provided and selling, general and administrative expenses. This had the impact
of improving profitability in those areas affected. At the time we prepared our
restructuring program, we estimated we would save approximately $3.1 million on
an annual basis. While our savings were significant, we did not achieve our
original estimate, principally because we have not realized any benefit from the
relocation of our primate colony, which has just been completed. Since we are
currently in the process of selling the entire colony, we will be unable to
measure the positive impact of the relocation.


     Allocation of Costs from Bausch & Lomb. Historically, B&L charged us for
certain direct expenses, including insurance, information technology and other
miscellaneous expenses, based upon actual charges incurred on our behalf.
However, these charges and estimates are not necessarily indicative of the costs
and expenses which would have resulted had we incurred these costs as a
stand-alone entity. The actual amounts of expenses we incur in future periods
may vary significantly from these allocations and estimates. We expect to incur
other incremental expenses as a stand-alone company. See "Unaudited Pro Forma
Condensed Consolidated Financial Data."

     The Transactions. The Recapitalization, which was consummated on September
29, 1999, was accounted for as a leveraged recapitalization, which will have no
impact on the historical basis of our assets and liabilities. The Sierra
Acquisition was accounted for under the purchase method of accounting with the
purchase price allocated to the assets and liabilities of Sierra based on an
estimate of their fair value, with the remainder, if any, being allocated to
goodwill. On a pro forma basis, we incurred various costs of approximately $19.6
million (pre-tax) in connection with consummating the Transactions. The portion
of these costs that represents deferred financing costs will be capitalized and
amortized over the life of the related financing. A portion of the expenses
related to the Recapitalization will be charged to retained earnings while the
portion related to the Sierra Acquisition will be included in the purchase
price.

     Deferred Tax Assets. In conjunction with the Recapitalization, we will make
an election under section 338(h)(10) of the Internal Revenue Code of 1986, as
amended. Such election results in a step-up in the tax basis of the underlying
assets. The resulting net deferred tax asset of $88.1 million is expected to be
realized over 15 years through future tax deductions which are expected to
reduce future tax payments. See Note (e) to the Unaudited Pro Forma Condensed
Consolidated Balance Sheet included in the Unaudited Pro Forma Condensed
Consolidated Financial Data.

     Results of Operations

                                       32
<PAGE>

     The following table summarizes historical results of operations as a
percentage of net sales for the periods shown:

     <TABLE>

                                                            Fiscal Year Ended                 Nine Months Ended
                                                ---------------------------------------------------------------------
                                                 December 28, December 27, December 26,  September 26,  September 25,
                                                     1996         1997         1998          1998           1999
                                                ------------- ------------ ------------  -------------  -------------
<S>                                                <C>          <C>          <C>            <C>            <C>
Net sales........................................  100.0%       100.0%       100.0%         100.0%         100.0%
Costs of products sold and service provided......   62.8         65.3         63.4           62.6           60.4
Selling, general and administrative expenses.....   18.2         17.8         17.7           17.3           18.3
Amortization of goodwill and other intangibles...    0.4          0.5          0.7            0.7            0.7
Restructuring charges............................    3.1          3.5           --             --             --
                                                   -----        -----        -----          -----          -----
Operating income.................................   15.5         12.9         18.2           19.4           20.6
                                                   -----        -----        -----          -----          -----
Net income.......................................    9.8%         9.0%        12.1%          12.7%          12.4%
                                                   =====        =====        =====          =====          =====
</TABLE>

Nine Months ended September 25, 1999 Compared to Nine Months ended
September 26, 1998

     Net Sales. Net sales for the first nine months of 1999 were $161.1 million,
an increase of $15.6 million, or 10.7%, from $145.5 million in the first nine
months of 1998.

     Research Models. Net sales of research models for the first nine months of
1999 were $109.2 million, an increase of $6.0 million, or 5.8%, from $103.2
million for the first nine months of 1998. Sales increased due to the increase
in small animal research model sales in North America and Europe, resulting from
improved pricing, a more favorable product mix and an increase in unit volume.
We also experienced growth in our primate import and conditioning business,
mainly due to pricing.

     Biomedical Products and Services. Net sales of biomedical products and
services for the first nine months of 1999 were $51.9 million, an increase of
$9.6 million, or 22.7%, from $42.3 million for the first nine months of 1998. At
the beginning of the second quarter of 1998, we acquired two new businesses that
contributed $2.8 million of this sales growth. The remaining increase was due to
significant sales increases of Special Animal Services and Endotoxin testing
kits, and sales from our facility management contracts, primarily due to better
customer awareness of our outsourcing solutions.

     Cost of Products Sold and Services Provided. Cost of products sold and
services provided for the first nine months of 1999 was $97.2 million, an
increase of $6.2 million, or 6.8%, from $91.0 million for the first nine months
of 1998.

     Research Models. Cost of products sold and services provided for research
models for the first nine months of 1999 was $65.4 million, an increase of $1.7
million, or 2.7%, compared to $63.7 million for the first nine months of 1998.
Cost of products sold and services provided for the first nine months of 1999
was 59.9% of net sales compared to 61.7% of net sales for the first nine months
of 1998. Cost of products sold and services provided increased at a lower rate
than net sales due to the more favorable product mix and better pricing, as well
as improved capacity utilization.

     Biomedical Products and Services. Cost of products sold and services
provided for biomedical products and services for the first nine months of 1999
was $31.8 million, an increase of $4.5 million, or 16.5%, compared to $27.3
million for the first nine months of 1998. Cost of products sold and services
provided for the first nine months of 1999 was 61.3% of net sales compared to
64.5% of net sales for the first nine months of 1998. Cost of products sold and
services provided increased at a lower rate than net sales, due to improved
utilization in our SPF egg business, and a favorable sales mix in our Special
Animal Services and biosafety testing businesses.

     Selling, General and Administrative Expenses. Selling, general and
administrative expenses for the first nine months of 1999 were $29.4 million, an
increase of $4.2 million, or 16.7% from $25.2 million for the first nine months
of 1998. Selling, general and administrative expenses for the first nine months
of 1999 were 18.2% of net sales, compared to 17.3% of net sales for the first
nine months of 1998. Selling, general and administrative expenses also included
research and development expense of $0.4 million for the first nine months of
1999 compared to $0.8 million for the same period in 1998.

                                       33


<PAGE>



     Research Models. Selling, general and administrative expenses for research
models for the first nine months of 1999 were $15.7 million, an increase of $2.5
million, or 18.9%, compared to $13.2 million, for the first nine months of 1998.
Selling, general and administrative expenses for the first nine months of 1999
were 14.4% of net sales, compared to 12.8% for the first nine months of 1998.
The increase was attributable to additional worldwide marketing efforts,
additional salespeople in the United States and the impact of selling efforts
in Europe for ESD, a business acquired at the end of 1998.

     Biomedical Products and Services. Selling, general and administrative
expenses for biomedical products and services for the first nine months of 1999
were $7.5 million, an increase of $0.9 million, or 13.6%, compared to $6.6
million for the first nine months of 1998. Selling, general and administrative
expenses for the first nine months of 1999 decreased to 14.5% of net sales,
compared to 15.6% of net sales for the first nine months of 1998, due to the
significant increase in sales.

     Unallocated Corporate Overhead. Unallocated corporate overhead, which
consists of various corporate expenses, was $6.2 million for the first nine
months of 1999, an increase of $0.8 million, or 14.8%, compared to $5.4 million
for the first nine months of 1998. The increase resulted from a number of items,
the most significant of which related to the write down of a small investment in
one of our joint ventures, which is undergoing significant financial
difficulties.

     Amortization of Goodwill and Other Intangibles. Amortization of goodwill
and other intangibles for the first nine months of 1999 was $1.1 million, an
increase of $0.1 million, or 10.0%, from $1.0 million for the first nine months
of 1998. The increase was due to the effect of three recent acquisitions, two in
April 1998 and one in December 1998.

     Restructuring Charges. There were no restructuring charges during the nine
months ended September 25, 1999 and September 26, 1998. During the nine months
ended September 25, 1999, we charged $0.8 million of previously reserved for
costs against the previously recorded restructuring reserves. The remaining
reserves, which primarily relate to continuing severance payments and relocation
and refoliation costs, are expected to be fully utilized by the end of 1999.

     Operating Income. Operating income for the first nine months of 1999 was
$33.3 million, an increase of $5.1 million, or 18.1%, from $28.2 million in the
first nine months of 1998. Operating income for the first nine months of 1999
was 20.7% of net sales, compared to 19.4% of net sales for the first nine months
of 1998. Operating income increased in total and as a percentage of net sales
for the reasons described below.

     Research Models. Operating income from sales of research models for the
first nine months of 1999 was $28.0 million, an increase of $1.7 million, or
6.5%, from $26.3 million in the first nine months of 1998. Operating income from
sales of research models for the first nine months of 1999 was 25.5% of net
sales, unchanged from the first nine months of 1998.

     Biomedical Products and Services. Operating income from sales of biomedical
products and services for the first nine months of 1999 was $11.5 million, an
increase of $4.2 million, or 57.5%, from $7.3 million in the first nine months
of 1998. Operating income from sales of biomedical products and services for the
first nine months of 1999 increased to 22.2% of net sales, compared to 17.3% of
net sales for the first nine months of 1998, due to improvements in pricing,
sales mix and cost savings achieved.

     Other Income. During the third quarter of 1999, we recorded a $1.4 million
gain on the sale of two small facilities, one located in Florida, and the other
located in the Netherlands.

     Income Taxes. The effective tax rate of 48.4% for the first nine months of
1999 as compared to 39.6% for the first nine months of 1998, reflects the
remittance of cash dividends of $20.7 million from our foreign subsidiaries
which, in turn, were remitted to B&L. The related amounts were previously
considered permanently reinvested in the foreign jurisdictions for U.S. income
tax reporting purposes, therefore, we were required to provide additional taxes
upon their repatriation to the U.S. In addition, during the nine months ended
September 25, 1999, an election was made by B&L to treat certain foreign
entities as branches for United States income tax purposes. As a result, all
previously untaxed accumulated earnings of such entities became immediately
subject to tax in the United States. The receipt of the cash

                                       34


<PAGE>



dividends from the foreign subsidiaries and the foreign tax elections made
resulted in incremental United States taxes of $2.0 million, net of foreign tax
credits, during the nine months ended September 25, 1999.

     Net Income. Net income for the first nine months of 1999 was $20.0 million,
an increase of $1.5 million, or 8.1%, from $18.5 million in the first nine
months of 1998. The increase was attributable to the factors described above.

Fiscal 1998 Compared to Fiscal 1997

     Net Sales. Net sales in 1998 were $193.3 million, an increase of $22.6
million, or 13.2%, from $170.7 million in 1997.

     Research Models. Net sales of research models in 1998 were $134.6 million,
an increase of $9.4 million, or 7.5%, from $125.2 million in 1997. Sales
increased due to the increase in small animal research model sales in North
America, resulting from improved pricing and a more favorable product mix. In
addition, in 1998 we were not affected by the significant contaminations which
negatively impacted sales in 1997. Overall, unit volumes remained relatively
flat, with modest increases in North America offset by modest declines in
Europe. Our net sales in our primate import and conditioning business also
increased as a result of expansion in our boarding and service business.

     Biomedical Products and Services. Net sales of biomedical products and
services in 1998 were $58.7 million, an increase of $13.2 million, or 59.7%,
from $45.5 million in 1997. During 1998 we acquired three businesses that
contributed $6.1 million of our sales growth. The remaining increase was due to
increased sales across all of our product lines, and in particular our Special
Animal Services and Endotoxin testing businesses.

     Cost of Products Sold and Services Provided. Cost of products sold and
services provided in 1998 was $122.5 million, an increase of $11.0 million, or
9.9%, from $111.5 million in 1997.

     Research Models. Cost of products sold and services provided for research
models for 1998 was $85.8 million, an increase of $3.3 million, or 4.0%,
compared to $82.5 million in 1997. Cost of products sold and services provided
for 1998 was 63.7% of net sales compared to 65.9% for 1997. Cost of products
sold and services provided increased for 1998 compared to 1997, but at a slower
rate than net sales due principally to better product mix and pricing as well as
greater economies of scale and improved production efficiencies.

     Biomedical Products and Services. Cost of products sold and services
provided for biomedical products and services for 1998 was $36.7 million, an
increase of $7.7 million, or 26.6%, compared to $29.0 million in 1997. Cost of
products sold and services provided was 62.5% of net sales in 1998 compared to
63.7% in 1997. Cost of products sold and services provided increased for 1998
compared to 1997, but at a slower rate than net sales due principally to cost
savings.

     Selling, General and Administrative Expenses. Selling, general and
administrative expenses in 1998 were $34.1 million, an increase of $3.6 million,
or 11.8%, from $30.5 million in 1997. Selling, general and administrative
expenses in 1998 were 17.6% of net sales compared to 17.9% of net sales in 1997.
These expenses increased mainly in line with sales. Selling, general and
administrative expenses also included research and development expense of $1.4
million in 1998, which was the same amount as in 1997.

     Research Models. Selling, general and administrative expenses for research
models for 1998 were $18.1 million, a decrease of $1.5 million, or 7.7%,
compared to $19.6 million, for 1997. Selling, general and administrative
expenses for 1998 decreased to 13.4% of net sales, compared to 15.7% for 1997
due primarily to the significant increase in sales.

     Biomedical Products and Services. Selling, general and administrative
expenses for biomedical products and services for 1998 were $9.7 million, an
increase of $2.8 million, or 40.6%, compared to $6.9 million for 1997. Selling,
general and administrative expenses for 1998 were 16.5% of net sales, compared
to 15.2% of net sales for 1997. The increase was principally attributable to the
acquisition of two small businesses in April 1998.

                                       35


<PAGE>



     Unallocated Corporate Overhead. Unallocated corporate overhead was $6.3
million for 1998, an increase of $2.3 million, or 57.5%, compared to $4.0
million in 1998. The increase was due to an increase in our supplemental
retirement program costs, along with an increase in management bonuses for 1998.

     Amortization of Goodwill and Other Intangibles. Amortization of goodwill
and other intangibles in 1998 was $1.3 million, an increase of $0.5 million, or
62.5%, from $0.8 million in 1998. The increase was due to the acquisition of two
small service businesses in April 1998.

     Restructuring Charges. There were no restructuring charges in 1998 compared
to $5.9 million in 1997 associated with the restructuring program discussed
above. During 1998, we charged $1.6 million of previously reserved for costs
against the previously recorded restructuring reserves.

     Operating Income. Operating income in 1998 was $35.3 million, an increase
of $13.2 million, or 59.7%, from $22.1 million in 1997. Operating income in 1998
was 18.3% of net sales compared to 12.9% of net sales in 1997.

     Research Models. Operating income from research models in 1998 was $30.5
million, an increase of $10.9 million, or 55.6%, from $19.6 million in 1997.
Operating income from sales of research models in 1998 increased to 22.7% of net
sales, compared to 15.7% of net sales in 1997 for the reasons described above.

     Biomedical Products and Services. Operating income from biomedical products
and services in 1998 was $11.1 million, an increase of $4.6 million, or 70.8%,
from $6.5 million in 1997. Operating income increased to 18.9% of net sales,
compared to 14.3% of net sales in 1997 for the reasons described above.

     Income Taxes.  The effective tax rate in 1998 was 39.4% compared to 38.3%
in 1997.

     Net Income. Net income in 1998 was $23.4 million, an increase of $8.1
million, or 52.9%, from $15.3 million in 1997. The increase was attributable to
the factors referred to above.

Fiscal 1997 Compared to Fiscal 1996

     Net Sales. Net sales in 1997 were $170.7 million, an increase of $15.1
million, or 9.7%, from $155.6 million in 1996.

     Research Models. Net sales of research models in 1997 were $125.2 million,
an increase of $3.9 million, or 3.2%, from $121.3 million in 1996. Sales
increased due to the increase in small animal research model sales in North
America, primarily due to improved pricing and a favorable product mix which
more than offset slight unit volume declines in Europe and flat unit volume
sales in North America. The unit volume declines were partially due to a number
of contaminations which occurred in 1996 and several contaminations in 1997,
which mostly impacted net sales in 1997. In addition, net sales in 1997 were
negatively impacted by foreign currency translations. Sales in our primate
business increased after our imported primates business was reacquired at the
beginning of the third quarter of 1996.

     Biomedical Products and Services. Net sales of biomedical products and
services in 1997 were $45.5 million, an increase of $11.2 million, or 32.7%,
from $34.3 million in 1996. The increase was due to increased sales of SPF eggs,
an increase in facility management contracts and the acquisition of our French
distributor for Endotoxin testing kits in the beginning of the second quarter of
1996.

     Cost of Products Sold and Services Provided. Cost of products sold and
services provided in 1997 was $111.5 million, an increase of $13.7 million, or
14.0%, from $97.8 million in 1996.

     Research Models. Cost of products sold and services provided for research
models for 1997 was $82.5 million, an increase of $6.5 million, or 8.6%,
compared to $76.0 million in 1996. Cost of products sold and services provided
for 1997 was 65.9% of net sales compared to 62.7% for 1996. Cost of products
sold and services provided increased for costs associated with biosecurity and
the prevention of contaminations.

                                       36
<PAGE>

     Biomedical Products and Services. Cost of products sold and services
provided for biomedical products and services for 1997 was $29.0 million, an
increase of $7.2 million, or 33.0%, compared to $21.8 million in 1996. Cost of
products sold and services provided for 1997 was 63.7% of net sales in 1997
compared to 63.6% in 1996.

     Selling, General and Administrative Expenses. Selling, general and
administrative expenses in 1997 were $30.5 million, an increase of $2.2 million,
or 7.8%, from $28.3 million in 1996. Selling, general and administrative
expenses in 1997 were 17.9% of net sales compared to 18.2% of net sales in 1996.
Selling, general and administrative expenses also included research and
development expense of $1.4 million in 1997, compared to $1.5 million in 1996.

     Research Models. Selling, general and administrative expenses for research
models for 1997 were $19.6 million, a decrease of $0.1 million, or 0.5%,
compared to $19.7 million, for 1996. Selling, general and administrative
expenses for 1997 were 15.7% of net sales, compared to 16.2% for 1996.

     Biomedical Products and Services. Selling, general and administrative
expenses for biomedical products and services for 1997 were $6.9 million, an
increase of $1.5 million, or 27.8%, compared to $5.4 million for 1996. Selling,
general and administrative expenses for 1997 were 15.2% of net sales, compared
to 15.7% of net sales for 1996.

     Unallocated Corporate Overhead.  Corporate overhead was $4.0 million for
1997, an increase of $0.8 million, or 25.0%, compared to $3.2 million in 1996.

     Amortization of Goodwill and Other Intangibles. Amortization of goodwill
and other intangibles in 1997 was $0.8 million, an increase of $0.2 million, or
33.3%, from $0.6 million in 1996. The increase was due to the acquisition of our
French distributor for Endotoxin testing kits in the beginning of the second
quarter of 1996.

     Restructuring Charges. Restructuring charges in 1997 were $5.9 million, an
increase of $1.2 million, or 25.5%, from $4.7 million in 1996. The 1997
restructuring charges consisted of the following: plant closings and personnel
reductions in our SPF egg business, severance costs and relocation costs for our
purpose bred primates in the Florida Keys and related refoliation costs and
staff reductions and associated severance costs in Europe and the United States.
The 1996 restructuring charges consisted of the following: plant closings in the
United States and Europe of the small animal business, personnel reductions at
our European headquarters, administrative staff reductions at the SPF egg
business, and shutdown or consolidations of several other small businesses.
During 1997, we charged $3.2 million of costs against the reserves recorded in
1997. The restructuring activities provided for in 1996 were completed by the
end of the year with actual charges approximating those originally provided for.


     Operating Income. Operating income in 1997 was $22.1 million, a decrease of
$2.0 million, or 8.3%, from $24.1 million in 1996. Operating income in 1997 was
13.0% of net sales compared to 12.9% net sales in 1996. Operating income
decreased in total and as a percentage of net sales due to the factors described
above.


     Research Models. Operating income from research models in 1997 was $19.6
million, a decrease of $4.5 million, or 18.7%, from $24.1 million in 1996.
Operating income from sales of research models in 1997 decreased to 15.7% of net
sales, compared to 19.9% of net sales in 1996 due primarily to biosecurity costs
and higher restructuring charges.


     Biomedical Products and Services. Operating income from biomedical products
and services in 1997 was $6.5 million, an increase of $3.2 million, or 97%,
from $3.3 million in 1996. Operating income from sales of biomedical products
and services in 1997 increased to 14.3% of net sales, compared to 9.6% of net
sales in 1996 due to the significant increase in sales.


     Income Taxes.  The effective tax rate in 1997 was 38.3%, compared to 44.6%
in 1996, due to higher foreign statutory tax rates in 1996.

     Net Income. Net income in 1997 was $15.3 million, an increase of $0.1
million, or 0.7%, from $15.2 million in 1996. The increase was attributable to
the factors referred to above.

                                       37
<PAGE>

Liquidity and Capital Resources

     Post-Transactions

     Our principal sources of liquidity are cash flow from operations and
borrowings under our new credit facility. Our principal uses of cash are debt
service requirements as described below, capital expenditures, working capital
requirements and acquisitions.

     On a pro forma basis, after giving effect to the Transactions, as of
September 25, 1999, we had:

   o total consolidated indebtedness of approximately $311.1 million

   o approximately $28.0 million of borrowings available under our new credit
     facility, subject to customary conditions

     Our significant debt service obligations following the Transactions could,
under certain circumstances, have material consequences to our security holders.
See "Risk Factors--Risks relating to our debt."

     The term loan facility under the new credit facility consists of a $40.0
million term loan A facility and a $120.0 million term loan B facility. The term
loan A facility matures six years after the closing date of the facility and the
term loan B facility matures eight years after the closing date of the facility.

     The new credit facility also includes a $30.0 million revolving credit
facility which matures six years after the closing date of the facility. The
revolving credit facility may be increased by up to $25.0 million at our
request, which will only be available to us under certain circumstances, subject
to a successful syndication under the same terms and conditions of the $30.0
million revolving credit facility.

     Loans under the term loan A facility and the revolving facility will bear
interest, at our option, at the alternate base rate or the reserve adjusted
LIBOR rate plus, in each case, applicable margins of 3.00% for LIBOR loans and
1.75% for base rate loans. Loans under the term loan B facility will bear
interest, at our option, at the alternate base rate or the reserve adjusted
LIBOR rate plus, in each case, applicable margins of 3.75% for LIBOR loans and
2.50% for base rate loans. We pay commitment fees in an amount equal to 0.50%
per annum on the daily average unused portion of the revolving credit facility.
Such fees are payable quarterly in arrears and upon the maturity or termination
of the revolving credit facility. Beginning approximately six months after the
closing date of the new credit facility, the applicable margins applicable to
loans under the term loan A facility and the revolving facility and commitment
fees will be determined based on the ratio (the "Leverage Ratio") of
consolidated total debt to consolidated EBITDA (as defined in the new credit
facility) of our company and our restricted subsidiaries (as defined in the new
credit facility).


     Although CRL Transaction Company, Inc., a newly formed wholly owned
subsidiary of Charles River, will guarantee the notes pursuant to the covenant
described under "Description of Notes -- Certain Covenants", CRL Transaction
Company Inc. is inconsequential to Charles River's consolidated results of
operation and financial position.


     All of our future domestic restricted subsidiaries will be guarantors of
the new credit facility. Our obligations under the new credit facility are or
will be secured by:

   o all of our stock,

   o all of our existing and after-acquired personal property and all the
     existing and after-acquired personal property of our future domestic
     restricted subsidiaries, including a pledge of all of the equity interests
     of all our future restricted subsidiaries held by us or any of our
     restricted subsidiaries and no more than 65% of the equity interests of any
     foreign restricted subsidiary, and all intercompany debt in our favor,

   o first-priority perfected liens on all of our material existing and
     after-acquired real property fee and leasehold interests, subject to
     customary permitted liens (as defined in the new credit facility), and

                                       38

<PAGE>
   o a negative pledge on all of our and our subsidiaries' assets.

     The new credit facility contains customary covenants and restrictions on
our ability to engage in certain activities, including, but not limited to:

   o limitations on other indebtedness, liens, investments and guarantees,

   o restrictions on dividends and redemptions and payments on subordinated debt
      and


   o restrictions on mergers and acquisitions, sales of assets and leases. The
     new credit facility also contains customary events of default and a
     cross-default to indebtedness of Charles River Laboratories Holdings.


     The notes mature in 2009. Interest on the notes is payable semi-annually in
cash. The notes contain customary covenants and events of default, including
covenants that limit our ability to incur debt, pay dividends and make certain
investments.


     We anticipate that we will spend approximately $15.0 million on a pro forma
basis for capital expenditures in 1999. The new credit facility contains
restrictions on our ability to make capital expenditures. Based on current
estimates, management believes that the amount of capital expenditures permitted
to be made under the new credit facility will be adequate to grow our business
according to our business strategy and to maintain the properties and businesses
of our continuing operations. We anticipate we will spend approximately $13.5
million for capital expenditures in 2000.


     Working capital totaled $31.9 million at September 25, 1999 on a pro forma
basis. Management believes that we will continue to require working capital
consistent with past experience and that current levels of working capital,
together with borrowings available under the new credit facility, will be
sufficient to meet expected liquidity needs in the near term.


     Reference should be made to Quantitative and Qualitative Disclosures about
Market Risk found on pages 42 and 43 where a table disclosing the Company's
total anticipated debt service requirements in the period 2000 through 2004 can
be found. We anticipate that our operating cash flow, together with borrowings
under the new credit facility, will be sufficient to meet our anticipated future
operating expenses, capital expenditures and the above debt service obligations
as they become due. However, our ability to make scheduled payments of principal
of, to pay interest on or to refinance our indebtedness and to satisfy our other
debt obligations will depend upon our future operating performance, which will
be affected by general economic, financial, competitive, legislative,
regulatory, business and other factors beyond our control. See "Risk Factors."


     From time to time we will continue to explore additional financing methods
and other means to lower our cost of capital, which could include stock issuance
or debt financing and the application of the proceeds therefrom to the repayment
of bank debt or other indebtedness. In addition, in connection with any future
acquisitions, we may require additional funding which may be provided in the
form of additional debt or equity financing or a combination thereof. There can
be no assurance that any such additional financing will be available to us on
acceptable terms.


     In connection with the Transactions, Charles River Laboratories Holdings,
Inc. issued $37.6 million aggregate principal amount of 16.27% senior discount
debentures with warrants to the DLJMB Funds and other investors. The senior
discount debentures accrete from their original issue price of $37.6 million to
$82.3 million by October 1, 2004. Thereafter, interest is payable in cash. The
senior discount debentures mature on April 1, 2010. The senior discount
debentures contain covenants and events of default substantially similar to
those contained in the notes. In addition, Holdings issued to the Rollover
Shareholders a subordinated discount note with an original issue price of $43.0
million. The subordinated discount note accretes at the rate of 12% prior to
October 1, 2004 and thereafter at 15% to an aggregate principal amount of $175.3
million at maturity on October 1, 2010. The subordinated discount notes are
subject to mandatory redemption upon a change of control at the option of the
holder thereof and are subject to redemption at Holdings' option at any time.


                                       39


<PAGE>

     Holdings has no source of liquidity other than dividends from Charles
River. Charles River's ability to pay dividends will be subject to limitations
contained in the indenture and the new credit facility.

   Historical

     Nine Months Ended September 25, 1999 Compared to Nine Months Ended
September 26, 1998

     Cash flow from operating activities for the nine months ended September 25,
1999 was $19.6 million compared to $23.5 million for the nine months ended
September 26, 1998 due to an increase in working capital.

     Net cash used in investing activities, consisting primarily of capital
expenditures and acquisitions, was $4.8 million for the nine months ended
September 25, 1999 compared to $14.3 million for the nine months ended September
26, 1998. The investing levels primarily change from year to year as the result
of spending on acquisitions. The large amount in 1998 primarily relates to the
acquisition of Tektagen, Inc. Capital expenditures were $7.4 million for the
nine months ended September 25, 1999, compared to $5.8 million for the nine
months ended September 26, 1998. There were not any significant capital
commitments at September 25, 1999. We continually monitor our capital spending
in relation to current and anticipated business needs. Our operations typically
do not require large capital expenditures and we anticipate that capital
spending will remain relatively consistent except for requirements related to
acquisitions.

     Net cash used in financing activities, consisting principally of net
activity with B&L, was $34.6 million for the nine months ended September 25,
1999 compared to $2.4 million for the nine months ended September 26, 1998. This
large increase relates principally to B&L dividending all excess cash in Charles
River Laboratories in connection with the Transactions.

     Fiscal 1998 Compared to Fiscal 1997

     Cash flow from operating activities in 1998 was $36.7 million compared to
$23.7 million in 1997, due to an increase in net income and a decrease in
working capital.

     Net cash used in investing activities in 1998 was $22.3 million compared to
$12.3 million in 1997. The increase in 1998 was primarily due to the acquisition
of Tektagen, Inc. Capital expenditures were $11.9 million in 1998, the same as
1997. Cash paid for acquisitions was $11.1 million in 1998, compared to $1.2
million in 1997.

     Net cash used in financing activities was $8.0 million in 1998 compared to
$12.9 million in 1997.  The decrease is due to less remittances to B&L.

     Fiscal 1997 Compared to Fiscal 1996

     Cash flow from operating activities in 1997 was $23.7 million compared to
$20.5 million in 1996, due to a decrease in working capital.

     Net cash used in investing activities in 1997 was $12.3 million compared to
$11.7 million in 1996. Capital expenditures were $11.9 million in 1997, compared
to $11.6 million in 1996.

     Net cash used in financing activities was $12.9 million in 1997 compared to
$4.1 million in 1996. The increase is due to increased remittances to B&L.

     We anticipate that our operating cash flow, together with borrowings under
the new credit facility, will be sufficient to meet our anticipated future
operating expenses, capital expenditures and debt service obligations as they
become due. However, our ability to make scheduled payments of principal of, to
pay interest on or to refinance our indebtedness and to satisfy our other debt
obligations will depend upon our future operating performance, which will be
affected by general economic, financial, competitive, legislative, regulatory,
business and other factors beyond our control. See "Risk Factors."

                                       40


<PAGE>



Year 2000 Compliance

     We have been addressing the potential risks associated with the year 2000
date issue. We are following a formal program developed by B&L to assess and
renovate internal information technology ("IT") and non-information technology
("non-IT") operations that are at risk, and further, to evaluate the year 2000
readiness of key third-party suppliers and recipients of products, services,
materials or data. Year 2000 issues are being addressed through a combination of
software replacement, system upgrades and, in limited instances, source code
modifications (collectively, "renovation"). Ongoing reengineering projects have
had the incidental benefit of remediating several major year 2000 issues.

     The assessment phase of IT systems is substantially complete. The
renovation phase is on schedule and all key IT systems are compliant as of
November 1999. We expect other IT systems to be tested and compliant by
mid-December 1999. For non-IT systems, we have utilized a leading production
systems integration firm specializing in year 2000 assessment and remediation of
manufacturing, laboratory and research and development facilities. The
assessment phase was fully completed during the second quarter of 1999. At this
time, all key non-IT systems have been tested and are compliant. We assessed the
readiness of key suppliers and customers in early 1999. We have interacted with
each major supplier or recipient of data, including face-to-face interviews with
many of those considered to be critical to our company. This assessment is
complete.

     Our anticipated costs, comprised of both period expenses and capital
expenditures, of identifying and remediating year 2000 issues on the
above-described areas, are not expected to exceed $1.5 million. The majority of
this work has been done by in-house personnel, which commenced in 1995.
Management believes that our year 2000 program will substantially reduce the
risk of a material adverse impact on future financial results caused by the year
2000 issue. Potential risks of a failure to address a year 2000 issue (whether
IT, non-IT, or external) that could have a materially detrimental impact to us
include the inability to manufacture or ship products, the inability to receive
and fill orders, and problems with customers or suppliers, including the loss of
electrical power or the failure of a key customer or supplier to purchase
products or provide anticipated goods and services. At this stage, we have
contingency plans for all our major facilities globally.

     On September 29, 1999, we acquired Sierra. We are currently working with
local management to implement the year 2000 compliance program of Charles River.
We expect to complete all phases by the end of the fourth quarter of 1999.



           QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

     Our primary market risk exposures are in the areas of interest-rate risk
and foreign currency exchange-rate risk.

     Our exposure to interest-rate risk arises from variable-rate and fixed-rate
debt arrangements entered into for other-than-trading purposes. To mitigate the
risks associated with increases in interest rates, we plan to enter into
interest-rate protection agreements for at least 50% of our total variable rate
debt amount.

     The table below summarizes our market risks associated with debt
obligations arising from the Transaction. The term loan and revolving loan will
bear interest, at our option, at prime or LIBOR, plus an applicable margin.
Effective interest rates shown in the table below for the term loan facility is
a weighted-average of interest rates, based on the current rates. Further, as
disclosed in the Summary Description of the Notes, the interest rate on the
subordinated debt is subject to increase to 14% per year on August 15, 2000 in
the event that we do not meet a specified ratio as of June 30, 2000.

<TABLE>
                                                                 Fiscal Year
                                   ------------------------------------------------------------------
                                       2000          2001          2002          2003        2004
                                       ----          ----          ----          ----        ----
<S>                                <C>           <C>           <C>           <C>          <C>
Subordinated Debt Balance......    $  150,000    $  150,000    $  150,000    $  150,000   $  150,000
Effective Interest Rate........          13.5%         13.5%         13.5%         13.5%        13.5%
Principal Payments.............             0             0             0             0            0


                                       41


<PAGE>




                                                                 Fiscal Year
                                   ------------------------------------------------------------------
                                       2000          2001          2002          2003        2004
                                       ----          ----          ----          ----        ----
<S>                                <C>           <C>           <C>           <C>          <C>

Interest Expense...............        20,250        20,250        20,250        20,250       20,250
Term Facility Balance..........       158,800       155,600       150,400       141,200      130,000
Effective Interest Rate........          9.69%         9.69%         9.70%         9.72%        9.76%
Principal Payments.............         1,200         3,200         5,200         9,200       11,200
Interest Expense...............        15,450        15,240        14,848        14,181       13,240
Revolver Balance...............             0             0             0             0            0
Available Credit...............        30,000        30,000        30,000        30,000       30,000
Fee on Unused Portion..........          0.50%         0.50%         0.50%         0.50%        0.50%
Interest Expense...............           150           150           150           150          150
</TABLE>

     We also have exposure to certain foreign currency exchange-rate
fluctuations for the cash flows received from our foreign affiliates. This risk
is mitigated by the fact that the operations of our subsidiaries are conducted
in their respective local currencies. Currently, we do not engage in any foreign
currency hedging activities as we do not believe that our foreign currency
exchange-rate risk is material.


                                       42
<PAGE>



                                    BUSINESS

                                  CHARLES RIVER

     Overview


     We are a global market leader in the commercial production and supply of
small animal research models for use in the discovery, development and testing
of new pharmaceuticals. The expansion of our core capabilities in research
models has enabled us to become a leading supplier of related biomedical
products and services in several specialized niche markets. Our research model
capabilities and biomedical products and services, together with our global
distribution network, allow us to meet the extensive needs of our broad customer
base. Our customers consist primarily of:


   o large pharmaceutical companies, including the ten largest global
     pharmaceutical companies based on 1998 revenues

   o biotechnology, animal health, medical device and diagnostics companies

   o hospitals

   o academic institutions

   o government agencies


     Our facilities are located in 18 countries, including the United States,
Canada, Japan and many European countries. On a pro forma basis, research models
accounted for 62%, and biomedical products and services accounted for 38%, of
net sales for the nine-month period ended September 25, 1999. Over the same time
period, we reported pro forma net sales of $177.1 million and pro forma Adjusted
EBITDA of $45.4 million. Adjusted EBITDA represents EBITDA, as defined, adjusted
for non-recurring, non-cash and cash items, as appropriate, which are more fully
described on page 12. EBITDA, as defined, represents operating income plus
depreciation and amortization. We present Adjusted EBITDA because we believe it
is a meaningful indicator of Charles River's operating performance, and it is
the measure by which certain of the covenants under the new credit facility are
computed. EBITDA, as defined, and Adjusted EBITDA are not intended to represent
cash flows for the period, nor are they presented as an alternative to operating
income or as an indicator of operating performance. They should not be
considered in isolation or as a substitute for measures of performance prepared
in accordance with GAAP in the United States and are not indicative of operating
income or cash flow from operations as determined under GAAP. Our method of
computation may not be comparable to other similarly titled measures of other
companies.

     Research Models. We have a leading position in the global market for
research models, which primarily consists of purpose-bred rats and mice. The use
of research models is often a critical part of scientific discovery in the life
sciences and is required by FDA guidelines as well as foreign regulatory
agencies for new drug approval processes. Our business is primarily involved in
the early stages of drug discovery and development, commonly referred to as the
pre-clinical stage of drug development. During this stage, promising new drug
candidates are evaluated for their efficacy and safety through testing in
research models. Data from the pre-clinical stage is submitted to the applicable
regulatory agency for review in order for the drug to obtain approval to advance
to the human testing stage, commonly known as clinical studies. We principally
produce and sell rats, mice, other rodents and primates (principally cynomolgus
monkeys) with highly defined health and genetic backgrounds, primarily for use
in pre-clinical research. Our research models include special disease rodent
models, such as mice with impaired immune systems, which are increasingly
demanded by biomedical researchers for specialized research and discovery. We
focus on maintaining reliable biosecurity, which includes stringent guidelines
to ensure contamination-free research models. As a result, we provide consistent
product availability and offer a wide variety of healthy, genetically defined
and specifically targeted research models. We further differentiate our research
models by providing extensive technical service and support, including
scientific oversight from a team of more than 70


                                       43


<PAGE>


full-time, dedicated professionals (DVMs, MDs and PhDs) specializing in
laboratory animal medicine, pathology and the study of viruses and primates, as
well as molecular biology and genetics.

     Biomedical Products and Services. The principal focus of our biomedical
products and services segment is to meet the research needs of large
pharmaceutical companies as well as biotechnology, animal health, medical
device and diagnostics companies. We are a leading supplier of endotoxin
testing kits that detect fever producing toxins in injectable drugs and
devices and are one of only two FDA validated in vitro alternatives to an
animal test. In addition, we are one of the world's largest producers of SPF
fertile chicken eggs, which are principally used to produce poultry vaccines.
Our other biomedical products and services, many of which are related to
technologies developed in our research model business, include:


   o transgenic animal production

   o medical device testing

   o contract research services

   o comprehensive health monitoring programs, including DNA testing, of animal
     colonies

   o testing services for human protein drug candidates

   o facility management services

Competitive Strengths

     Long-Standing Relationships with an Extensive Customer Base. Our customers
consist primarily of large pharmaceutical companies, including the ten largest
global pharmaceutical companies based on 1998 revenues, as well as
biotechnology, animal health, medical device and diagnostics companies and
hospitals, academic institutions and government agencies. We have many
long-term, stable relationships with our customers as evidenced by the fact that
all of our top 20 customers in 1989 remain our customers today. We have further
strengthened our customer relationships by offering related biomedical products
and services to our research model customers. Our customer base is also
diversified with no individual customer accounting for more than 3% of net sales
in 1998 and the top 30 customers representing approximately 30% of total net
sales.

     Critical Component of Pharmaceutical Research. The research models we
supply are essential to the new drug discovery and development process. FDA
guidelines and certain foreign regulatory agencies for many years have required
that new drug candidates be tested on two separate animal species in the
pre-clinical stage. According to the Pharmaceutical Research and Manufacturers
of America, total research and development spending in the United States by
research-based pharmaceutical companies was $17 billion in 1998. While
pharmaceutical companies generally invest large sums of money in developing new
drugs, the purchase of research models typically represents an immaterial
portion of the cost to commercialize a new drug. As a result, most customers are
principally focused on the quality of the research model which is critical for
achieving accurate and reproducible study results and facilitating timely FDA
approval of new drug candidates. For these reasons, our reputation for high
quality models and consistent product availability enable us to maintain and
expand our customer relationships.


     Leading Market Position. We believe that our worldwide infrastructure,
global staff of nearly 100 scientific professionals, 50 years of operating
history and reputation of Charles River and its predecessors for high quality
products have established us as a global market leader in the commercial
production and supply of research models. We maintain our leadership position
through our well-established customer relationships, extensive high quality
product offerings and our ability to provide complementary services. Our
market leadership in research models has allowed us to capitalize on the
significant research and development spending by large pharmaceutical
companies, and more recently on outsourcing trends by our customers who are
increasingly contracting out to others functions that were previously done
internally, such as conducting tests of new drug compounds for efficacy or
safety in animals.

     Global Presence. We are a global provider of research models, with 49
facilities in the United States, Canada, Japan and many European countries. On a
pro forma basis, our international business contributed approximately 35% of our
net sales for the nine-month period ended September 25, 1999. We believe that
as our customers continue to


                                       44


<PAGE>


expand globally, they are likely to prefer to deal with a select number of
suppliers who have the ability to offer them a wide range of products and
services worldwide and in a timely manner. In addition, our customers benefit
from our global presence because it reduces potential exposure to biosecurity
risks and, minimizes regulatory restrictions and costs relating to transporting
research models over long distances. We provide our customers with uniform and
consistent research models regardless of the location of their research study.


     Experienced and Motivated Management Team. Our senior management team has
extensive experience in supplying the biomedical research industry, and an
average of 17 years of experience with Charles River. Our senior management
team, led by our chief executive officer, James C. Foster, has successfully
grown our business, secured our current strong market positions, integrated
eight strategic acquisitions since 1992 and positioned us for growth. Our senior
management team has broadened our pure research model focus to also include
being a leading supplier of biomedical products and services in several
specialized niche markets. As a result of the recapitalization of our business,
our management team indirectly holds 6.1% of the equity of Charles River, and
expects to have the option to acquire additional equity of Charles River through
a customary equity incentive plan.

Business Strategy


     Increase Sales in Research Models. We believe we can continue to increase
our market share in this segment by introducing new research models, providing
exceptional technical service and support, increasing our existing price
structure and product mix and maintaining reliable biosecurity. In general, we
have been able to increase our prices at rates that are above the rate of
inflation in the United States by maintaining high quality and specialized
products, enhancing service and improving availability. We also have been
focused on periodically adding higher value research models to our portfolio.
These higher value research models tend to be premium priced, targeted towards
specific disease conditions and provide us with an enhanced product mix that
contributes to moderate but sustained growth in the research model business. We
expect to continue to expand this segment, both through sustained growth in
demand for already introduced models and the introduction of new models.

     Expand Biomedical Products and Services. Our biomedical products and
services segment has been our fastest growing segment over the past several
years. We believe we can continue to grow this business by capitalizing on
outsourcing trends, building upon our existing capabilities and increasing our
global sales.

          Capitalize on Outsourcing Trends. Much of our increases in offerings
     of biomedical products and services have been in response to the
     increasing outsourcing trends within the pharmaceutical industry. We
     believe this shift toward increased outsourcing began in response to the
     pharmaceutical companies' growing capabilities in identifying potential
     new drug compounds and the resulting resource constraints placed on
     pharmaceutical research infrastructures by non-core activities. By
     outsourcing their non-core activities to us, our customers can focus on
     proprietary drug development and streamline their drug development
     process. In response, we have expanded our offerings to include many
     pre-clinical research activities undertaken by our customers.


          Build Upon Our Existing Capabilities. As a result of our strong
     position in research models, our global presence and our professional
     expertise, we have the unique capability to offer related biomedical
     products and services to many of our customers. We intend to build upon
     this expertise to capture more outsourcing business opportunities by using
     our existing infrastructure, reputation for quality and extensive customer
     contacts. We believe there are numerous other opportunities for increasing
     our share of high value pre-clinical research services and products.


          Increase Our Global Sales. Our current biomedical products and
     services customer base is primarily composed of our domestic research
     model customers. We intend to continue to offer and sell new biomedical
     products and services to our existing international research model
     customers as well as seek new international customers for this segment.
     We believe that we can rapidly increase our global presence in this area
     by taking advantage of our existing international customer relationships
     and infrastructure.



                                       45


<PAGE>



     Undertake Strategic Acquisitions and Alliances. We have a history of
acquiring and successfully integrating small companies in both our research
model and our biomedical products and services businesses. We expect that
strategic acquisitions will continue to provide an additional source of
long-term growth. In addition, we believe that our association with GHCP, one of
our equity investors, will assist us in identifying attractive acquisition
candidates while expanding our existing business. GHCP, which is comprised of
several experienced healthcare executives, has a strategic partnership with
DLJMB to invest in healthcare related businesses. The founding partners of GHCP
who are represented on the Charles River board include Henry Wendt, former
Chairman of SmithKline Beecham Corporation, Robert Cawthorn, former Chairman and
CEO of Rhone-Poulenc Rorer Inc. and Douglas Rogers, founder of Kidder, Peabody's
Health Care Group.

Business Segments

     Our business is divided into two segments, research models and related
biomedical products and services.

Research Models

     The research model business is our core business and accounted for 70% of
our 1998 sales. The business is principally comprised of small animals (rats,
mice and other rodents), and primates.

     Small Animal Models

     Our largest product line is the small animal models group, which consists
primarily of the production and sale of large numbers of purpose-bred rats and
mice to researchers. We believe we are a commercial leader in this business,
supplying rodents for research since 1947. We began as a supplier of outbred
rats, with genetic characteristics representative of a random population, and
over the years added other small animal species and strains to our product mix.
We have also added inbred animals, which have essentially identical genes,
hybrid animals, which are the offspring of two different inbred parents,
spontaneous mutant animals, which contain a naturally occurring genetic mutation
(such as immune deficiency) and transgenic animals, which contain genetic
material transferred from another source. We believe we offer one of the largest
selections of small animal models and provide our customers with high volume and
high quality production. Our rats, mice and other rodent species (e.g., guinea
pigs, hamsters) have been and continue to be some of the most extensively used
research models in the world, largely as a result of our continuous commitment
to innovation and quality in the breeding process. We provide our small animal
models to numerous customers around the world, including pharmaceutical and
biotechnology companies and hospitals and universities.

     The most common use of our small animal models is for the screening,
discovery and testing of new drug candidates. For example, in order for a
pharmaceutical company to file a complete submission for FDA approval of a new
drug, it must provide evidence of safe and effective testing on two species of
animal models, one small and one large, before moving into the clinic for
testing on humans. Animal testing is used in order to identify, define,
characterize and assess the safety of new drug candidates. Outbred, and
increasingly, inbred mice are often the model of choice in early discovery and
development work, while outbred rats are frequently used in safety assessment
studies. Our models are also used in basic life science research within
universities, hospitals and other research institutions. Unlike drug discovery,
these uses are generally not specifically mandated by regulatory agencies such
as the FDA, but instead are governed by the terms of government grants,
institutional protocols as well as the scientific inquiry and peer review
publication processes.

     Primates


     We provide primates to the research community, principally for use in
drug development and testing studies. The primates we provide are most often
cynomolgus monkeys sourced from the island of Mauritius, which are both
purpose bred and wild caught. Primates are often used as the required large
animal species in FDA or similar regulated testing protocols. We believe that
the use of primates has been moderately increasing recently, as they are often
the preferred model for testing the growing number of new drug candidates
derived from human proteins, such as drugs developed in AIDS research.


                                       46


<PAGE>



    Our largest primate business is located in Houston, where we import,
quarantine, condition, hold and sell primates exported to us by our supplier
in Mauritius. We believe that these primates are unique, in that they are
naturally free of herpes B virus, a common virus present in the species which
is transmissible to humans in a highly toxic form. We have a long-term supply
contract under which our supplier provides us with a reliable stream of
purpose-bred and wild caught animals. The contract expires in December 31,
2005 but is automatically renewed for an additional five-year period unless it
is breached. We also have a primate import and quarantine facility in the
United Kingdom. The importing and care of these animals is not an FDA
regulated activity, but rather it is principally a USDA and CDC regulated
activity.


Biomedical Products and Services

     Biomedical products and services include our newer, higher growth
businesses, such as: SPF eggs; endotoxin testing; special animal services;
diagnostics; biosafety testing; facility management; and medical device testing.

     SPF Eggs

     Fertile SPF chicken embryos within eggs are often used by animal health
companies as a living "bioreactor," or self-contained manufacturing vehicle, to
grow large quantities of live or killed avian viruses. These viruses are then
used as the raw material in poultry vaccines. We are a leading supplier to the
major global manufacturers of poultry vaccines, researchers and other users. We
also provide specially raised SPF eggs for some human vaccines. We have entered
into an agreement with a company that is in the FDA approval process for a nasal
spray flu vaccine for human use that, if commercially successful, may
significantly increase our existing SPF eggs business.

     We have a worldwide presence that includes several SPF eggs production
facilities in the United States, as well as facilities in Germany and in
Australia. We have a joint venture in Mexico and a franchise in India. We also
operate a specialized avian laboratory in Storrs, Connecticut which provides
support services to our customers.

     Endotoxin Testing

     We are a market leader in the endotoxin testing business, which is used to
test quality control samples of injectable drugs and devices, their components
and the processes under which they are manufactured, for the presence of
endotoxin. Endotoxins are fever producing pathogens or toxic compounds that are
highly toxic to humans when sufficient quantities are introduced into the body.
Quality control testing for endotoxin contamination by our customers is a
mandatory FDA requirement for injectable drugs and devices, and the manufacture
of the test kits and reagents is regulated by the FDA as a medical device.
Endotoxin testing uses a processed extract from the blood of the horseshoe crab,
known as limulus amebocyte lysate, or "LAL." The LAL test is the first and one
of the only FDA validated in vitro alternatives to an animal model test,
specifically the rabbit pyrogen test. The process of extracting blood is not
harmful to the crabs, which are subsequently returned to their natural ocean
environment. We produce and distribute test kits and reagents to pharmaceutical
and biotechnology medical device and product companies on a global basis.

     Special Animal Services

     Special Animal Services, or SAS, provides services for our customers to
help them maintain, improve, breed and test animals purchased or created by them
for biomedical research activities. Our special animal services business
includes: transgenic breeding, model characterization and scale-up, genetic
testing and characterization, quarantine, embryo cryopreservation, embryo
transfer, rederivation, and health and genetic monitoring. We provide these
services to more than 100 customers around the world, from pharmaceutical and
biotechnology companies to hospitals and universities, and maintain more than
150 different lines of research models. Our Contract Research Services business
is a discrete unit within the SAS business that provides more advanced or
specialized research model studies. These projects not only capitalize on our
strong historical research model capabilities, but also exploit more recently
developed capabilities in protocol development, animal micro-surgery, dosing
techniques, drug efficacy testing and data management and analysis. We initiated
SAS five years ago in response to our customers' outsourcing needs. The business
is managed and staffed by a senior team that was trained and developed
internally. This business leverages the technologies and relationships
associated with our research model business.

                                       47


<PAGE>



     Diagnostics

     Diagnostics is an internally developed business that was built upon the
scientific foundation created by the diagnostic laboratory needs of our research
model business. We now provide commercial laboratory services to monitor and
analyze the health and genetics of our customers' research models used in their
research protocols. We may serve as the customer's sole source testing
laboratory, or as a back-up source supporting some internal capability. Our
diagnostics business is principally located in Wilmington, Massachusetts and
Troy, New York.

     Biosafety Testing

     We recently entered the evolving business generally known as "biosafety
testing." This is a specialized area of non-clinical quality control testing
that is frequently outsourced by both pharmaceutical and biotechnology
companies. The testing services we provide allow the customer to determine if
the human protein drug candidates, or the process for manufacturing those
products, are essentially "pure," or free of residual biological materials. The
bulk of this testing work is required by the FDA, either for obtaining new drug
approval or maintaining a licensed manufacturing capability. Our scientific
staff consults with customers in the areas of process development, validation,
manufacturing scale-up, and biological tests. Our biosafety business is located
in Malvern, Pennsylvania.

     Facility Management

     Facility management involves managing the animal care function and
facilities on behalf of government, academic, pharmaceutical and biotechnology
companies. This business builds upon our core capabilities as a leading provider
of high quality research models. We now manage all or a part of the animal care
facilities of several commercial, government and academic institutions in both
the United States and Europe.

     Medical Device Testing

     We have capabilities in medical device testing that are complementary to
our research model business, especially in the large and growing cardiovascular
field, using large research models. This business also provides services in
support of animal and human health research, most notably in the area of new
drug and vaccine development and experimental xenotransplantation of whole
organs and tissues from swine to humans. Our medical device testing business is
located in Southbridge, Massachusetts.

     Sierra

     Sierra, which we recently acquired, is a pre-clinical biomedical services
company with expertise in drug safety and efficacy assessment studies using
research models. Sierra offers its services to biotechnology, pharmaceutical and
medical device companies that are principally focused on conducting studies
needed in the early stages of drug development, especially those that require
highly specialized scientific capabilities. Sierra has expertise in conducting
critical developmental studies on potential new drugs and devices using research
models, including short-term evaluations of potential new treatment for human or
animal disease conditions.

Customers

     Our customers consist primarily of large pharmaceutical companies,
including the ten largest pharmaceutical companies based on 1998 revenues, as
well as biotechnology, animal health, medical device and diagnostic companies
and hospitals, academic institutions and government agencies. We have many
long-term, stable relationships with our customers as evidenced by the fact that
all of our top 20 customers in 1989 remain our customers today.

     During 1998, in both the research models and biomedical products and
services businesses, approximately two-thirds of our sales were to
pharmaceutical and biotechnology companies, and the balance to hospitals,
universities and the government.

                                       48


<PAGE>



Sales, Marketing and Customer Support

     We sell our products and services principally through a direct sales force.
As of September 25, 1999, we have approximately 51 employees engaged in field
sales, of which 30 are in the United States, 12 are in Europe and 9 are with our
joint venture company in Japan. The direct sales force is supplemented by a
network of international distributors for certain of our biomedical product and
services businesses.

     Our internal marketing groups support the field sales staff, while
developing and implementing programs to create close working relationships with
customers in the biomedical research industry. Our web site, www.criver.com, is
an effective marketing tool, and has become recognized as a valuable resource in
the laboratory animal field by a broad spectrum of industry leaders. Our website
is not incorporated by reference in this prospectus.

     We maintain both a customer service and technical assistance department,
which services our customers' routine and more specialized needs. We frequently
assist our customers in solving problems related to animal husbandry, health and
genetics, biosecurity, protocol development and other areas in which our
internal expertise is recognized as a valuable customer resource.

Research and Development

     We do not maintain a fully dedicated research and development staff.
Rather, this work is done on an individual project basis or through a university
or other forms of collaborations. Our annual dedicated research and development
spending was $1.5 million in 1996, $1.4 million in 1997, $1.4 million in 1998
and $0.4 million for the nine months ended September 25, 1999. Our approach to
developing new products or services is to extend our base technologies into new
applications and fields, and to license or acquire technologies to serve as a
platform for the development of new businesses that service our existing
customer base. Our research and development focus is principally on developing
projects that improve our productivity or processes.

Industry Support and Animal Welfare

     Among the shared values of our employees is a concern for and commitment to
animal welfare. We have been in the forefront of animal welfare improvements in
our industry, and continue to demonstrate our commitment with special
recognition programs for employees who demonstrate an extraordinary commitment
in this critical area of our business.

     We support a wide variety of organizations and individuals working to
further animal welfare as well as the interests of the biomedical research
community. We fund internships in laboratory animal medicine, provide financial
support to non-profit institutions that educate the public about the benefits of
animal research, and provide awards and prizes to outstanding leaders in the
laboratory animal medicine field. Our primate import business dedicates a
portion of its net sales, through a royalty, to support similar programs and
initiatives.

Employees

     As of September 25, 1999, we have approximately 2,430 employees, including
nearly 100 professionals with advanced degrees (DVMs, PhDs and MDs). Our
employees are not unionized in the United States, though we are unionized in
certain European locales, consistent with local custom for our industry. We
believe that we have a good relationship with our employees.

Competition

     Our strategy is to be the leader in each of the markets in which we
participate. Our competitors are generally different in each of our business
areas.

     In our research models business segment, we have three smaller competitors
in the United States, several smaller ones in Europe, and two in Japan. Of our
main United States competitors, two are privately held businesses and the third

                                       49


<PAGE>



is a government financed non-profit institution. We believe that none of our
competitors for research models has our comparable global reach, financial
strength, breadth of product offering or pharmaceutical industry relationships.

     We have several competitors in our biomedical products and services
business segment. A few of our competitors in our biomedical products and
services business are larger than we are; however, many are smaller and more
regionalized. Expansion by our competitors in other areas in which we operate
could affect our competitive position. Of all of our businesses, we have the
smallest relative share in the biosafety testing market, where the market leader
is a well established company.

     We generally compete on the basis of quality, reputation, and availability,
which is supported by our international presence with strategically located
facilities.

Environmental Matters; Legal Proceedings

     Our operations and properties are subject to extensive foreign and federal,
state and local environmental protection and health and safety laws and
regulations. These laws and regulations govern, among other things, the
generation, storage, handling, use and transportation of hazardous materials and
the handling and disposal of hazardous and biohazardous waste generated at our
facilities. Under such laws and regulations, we are required to obtain permits
from governmental authorities for certain operations. If we violate or fail to
comply with these laws, regulations or permits, we could be fined or otherwise
sanctioned by regulators. Under certain environmental laws and regulations, we
could also be held responsible for all of the costs relating to any
contamination at our past or present facilities and at third party waste
disposal sites.

     Although we believe that our costs of complying with current and future
environmental laws, and our liabilities arising from past or future releases of,
or exposure to, hazardous substances will not materially adversely affect our
business, results of operations or financial condition, we cannot assure you
that they will not do so.

     We have for many years been engaged in disputes with federal, state and
local authorities and private environmental groups regarding damage to mangrove
plants resulting from our maintaining a free range primate breeding operation on
two islands we purchased in the Florida Keys. To settle our disputes, we have
agreed to move the primates off the islands, and thereafter transfer the real
property to the government. We have also agreed to refoliate the islands at our
cost, restoring them to their conditions prior to our arrival. Despite our best
efforts, we have not been able to successfully replant the lost mangroves,
principally due to the presence of a free range animal population and storms. We
believe that we will finally resolve these disputes by successfully refoliating
the islands over the next three years.

     We are not a party to any other material legal proceedings, other than
ordinary routine litigation incidental to our business which is not otherwise
material to our business or financial condition.

Regulatory Matters


          Certain of our business activities are currently regulated by the AWA,
which governs the treatment of certain animals intended for use in research.
Much of our United States small animal research model business, which is
predominantly rats and mice, is not subject to regulation under the AWA although
we comply with licensing and registration requirement standards set by the USDA
for handling animals, including breeding, maintenance and transportation of our
animals. Birds, including the chickens used in our United States SPF egg
business, are also not subject to AWA regulations. However, the USDA, which
enforces the AWA, is presently considering changing the regulations issued
pursuant to the AWA, in light of judicial action, to include rats, mice and
birds within its coverage. The AWA imposes a wide variety of specific
regulations on producers and users of animal subjects, most notably cage size,
shipping conditions and environmental enrichment methods. Our animal
production facilities in the United States are accredited by a highly regarded
member association known as AAALAC, which maintains standards that often
exceed those of the USDA.



                                       50


<PAGE>


     Our biomedical products and services businesses are also generally
regulated by the USDA, and in the case of our endotoxin testing business, the
FDA. Our manufacture of test kits and reagents for endotoxin testing is subject
to regulation by the FDA, under the authority of the Federal Food, Drug, and
Cosmetic Act. We are required to register with the FDA as a device manufacturer
and are subject to inspection on a routine basis for compliance with the FDA's
Quality System Regulations. These regulations require that we manufacture our
products and maintain our documents in a prescribed manner with respect to
manufacturing, testing and control activities. We are in receipt of a "warning
letter" from the FDA for quality control deficiencies with regard to our
Charleston, South Carolina facility, and are attempting to address the agency's
concerns. See "Risk Factors--We must comply with many federal, state and local
rules and regulations."

Properties

     The following charts provide summary information on our properties. The
first chart lists the sites we own, and the second chart the sites we lease.
Most of our material leases expire from 2000 to 2005.


                                  Sites--Owned

<TABLE>


                                      No. of
Country                               Sites           Total Square Feet          Principal Functions
- ------------------------------------- -------        -------------------   -------------------------------
<S>                                       <C>              <C>              <C>
Canada...............................       1                 48,789         Office, Production, Laboratory
France...............................       3                373,214         Office, Production, Laboratory
Germany..............................       3                122,314         Office, Production, Laboratory
Italy................................       1                 36,677         Office, Production, Laboratory
Japan................................       3                114,831         Office, Production, Laboratory
Netherlands..........................       1                  6,502                     Office
United Kingdom.......................       2                 67,331         Office, Production, Laboratory
USA..................................      19                732,980         Office, Production, Laboratory
China................................       1                 10,000         Office, Production, Laboratory
                                           --              ---------
Total................................      34              1,512,638
                                           ==              =========

</TABLE>


                                                     Sites--Leased

<TABLE>

                                      No. of
Country                               Sites           Total Square Feet          Principal Functions
- ------------------------------------- -------        -------------------   -------------------------------
<S>                                   <C>              <C>                 <C>
Australia............................       1                16,787               Office, Production
Belgium..............................       1                16,140               Office, Production
Czech Republic.......................       1                23,704         Office, Production, Laboratory
Hungary..............................       1                 4,681         Office, Production, Laboratory
Spain................................       1                 3,228             Production, Laboratory
Sweden...............................       1                 8,070                   Production
USA(1)...............................      10               255,895         Office, Production, Laboratory
                                        -----               -------
Total................................      16               328,505
                                        =====               =======
</TABLE>
- -------------------
(1)  Includes two properties leased by Sierra with a total square footage of
     116,751 square feet.

                                       51


<PAGE>


                                   MANAGEMENT


 The following table sets forth the name, age and position of each person
who is an executive officer, significant member of our management, or director
of our company. Each director has been a director of our company as of the
Recapitalization. Further, each director also serves as a director of Charles
River Laboratories Holdings, and has been a director of Charles River
Laboratories Holdings as of the Recapitalization.

<TABLE>

Name                                                  Age        Position
- -----                                                 -----      -----
<S>                                                   <C>        <C>

James C. Foster..................................       48       President, Chief Executive Officer and Director
Real H. Renaud...................................       52       Senior Vice President and General Manager,
                                                                 European and North American Animal Operations
Thomas F. Ackerman...............................       45       Senior Vice President and Chief Financial Officer
David P. Johst...................................       37       Senior Vice President, Human Resources and
                                                                 Administration
Dr. Charn Sun Lee................................       55       Vice President, Asian Operations
Julia D. Palm....................................       52       Vice President and General Manager, Biotech
                                                                 Products and Services
Dennis R. Shaughnessy ...........................       41       Senior Vice President, Corporate Development,
                                                                 General Counsel and Secretary
Dr. Jorg M. Geller...............................       43       Vice President, Charles River Europe;
                                                                 President, Charles River SPAFAS
Gilbert M. Slater................................       61       Vice President, Sales & Marketing
Robert Cawthorn..................................       63       Director
Stephen D. Chubb.................................       55       Director
Thompson Dean....................................       41       Director
Stephen C. McCluski..............................       47       Director
Reid S. Perper...................................       40       Director
Douglas E. Rogers................................       44       Director
William Waltrip..................................       62       Director
Henry C. Wendt...................................       66       Director


</TABLE>


     James C. Foster joined Charles River in 1976 as General Counsel. Over the
past 23 years, Mr. Foster has held various staff and managerial positions with
Charles River, culminating in Mr. Foster being named Charles River's President
and Chief Operating Officer in 1991. He has served as our President and Chief
Executive Officer since 1992. Mr. Foster also serves on the Board of Directors
of BioTransplant, Inc.

     Real H. Renaud joined Charles River in 1964 and has 35 years of small
animal production and related management experience. In 1986, Mr. Renaud became
Charles River's Vice President of Production, with responsibility for overseeing
our North American small animal operations, and was named Vice President,
Worldwide Production in 1990. Mr. Renaud assumed his current position in 1996,
following a two-year European assignment during which he provided direct
oversight to Charles River's European operations.

     Thomas F. Ackerman joined Charles River in 1988 with over eleven years of
combined public accounting and international finance experience. He was named
Controller, North America in 1992 and became our Vice President and Chief
Financial Officer in 1996. He is currently responsible for overseeing Charles
River's Accounting and Finance Department, as well as our Information Management
& Technology Group. Prior to joining Charles River, Mr. Ackerman was an
accountant at Arthur Anderson & Co.

                                       52


<PAGE>



     David P. Johst joined Charles River in 1991 as Corporate Counsel and was
named Vice President, Human Resources in 1995. He assumed his current position
in 1996, and is responsible for overseeing Charles River's Human Resources
Department, as well as several other corporate staff departments. He also serves
as our attorney on labor relations matters. Prior to joining Charles River, Mr.
Johst was a corporate associate at Boston's Hale and Dorr.

     Dr. Charn Sun Lee joined Charles River in 1975 as a Staff Veterinarian and
has 24 years of experience in laboratory animal medicine. In 1995, Dr. Lee was
named Vice President, Asian Operations and serves as our primary corporate
liaison in dealings with Charles River Japan, providing both business and
technical support.


     Julia D. Palm joined Charles River in 1995 with nearly 20 years of
management and marketing experience in the medical device and biotechnology
industries. Prior to joining Charles River, she held various marketing positions
with Becton Dickinson, National Medical Care and W. R. Grace, and served as
President of W.R. Grace's Amicon Division immediately prior to joining us. Ms.
Palm has responsibility for overseeing our portfolio of biotechnology
companies on a worldwide basis.


     Dennis R. Shaughnessy joined Charles River in 1988 as Corporate Counsel and
was named Vice President, Business Affairs in 1991. Prior to joining Charles
River, Mr. Shaughnessy was a corporate associate at Boston's Testa, Hurwitz &
Thibeault and previously served in government policy positions. He assumed his
current position in 1994 and is responsible for overseeing our business
development initiatives on a worldwide basis, as well as handling our overall
legal affairs. Mr. Shaughnessy also serves as our Corporate Secretary.

     Dr. Jorg M. Geller joined Charles River in 1986 as Production Manager for
German operations. In 1994, Dr. Geller was named Vice President, Charles River
Europe, with responsibility for overseeing operations in Germany and Eastern
Europe, as well as implementing Charles River's strategic growth and
diversification initiatives in the European market. In 1997, Dr. Geller became
President of Charles River's SPAFAS subsidiary where he oversees the worldwide
operations of SPAFAS in addition to his current European responsibilities.

     Gilbert M. Slater joined Charles River in 1960, in connection with our
acquisition of a privately held laboratory animal supplier which included Mr.
Slater as one of its principals. Mr. Slater assumed his position as Vice
President of Sales & Marketing in January of 1998. Mr. Slater has extensive
knowledge of the U.S. market for laboratory research animals based on more than
40 years of direct sales and customer relations experience. Mr. Slater also
oversees Charles River's industry relation initiatives and serves as our key
point of contact in dealings with major laboratory animal customers.


     Robert Cawthorn has been a Managing Director of Global Health Care
Partners, a group of DLJ Merchant Banking, Inc. since 1997. Mr. Cawthorn was
Chief Executive Officer and Chairman of Rhone-Poulenc Rorer Inc. until May
1996. Further, he previously served as an Executive Officer of Pfizer
International and the first President of Biogen Inc. Mr. Cawthorn serves as a
director of CBS Corporation and Sunoco, Inc.


     Stephen D. Chubb has been Chairman, Director and Chief Executive Officer of
Matritech, Inc. since its inception in 1987. Previously, Mr. Chubb served as
President and Chief Executive Officer of T Cell Sciences, Inc. and as President
and Chief Executive Officer of Cytogen Company.

     Thompson Dean has been a Managing Partner of DLJ Merchant Banking, Inc.
since November 1996. Previously, Mr. Dean was a Managing Director of DLJ
Merchant Banking, Inc. and its predecessor since January 1992. Mr. Dean serves
as a director of Commvault Inc., Von Hoffmann Press, Inc., Manufacturer's
Services Limited, Phase Metrics, Inc., AKI Holdings Corp., Amatek Ltd., DeCrane
Aircraft Holdings Inc., Insilco Holding Corporation, Formica Corporation and
Mueller Group, Inc.

     Stephen C. McCluski has been Senior Vice President and Chief Financial
Officer of Bausch & Lomb Incorporated since 1995. Previously, Mr. McCluski
served as Vice President and Controller of Bausch & Lomb Incorporated and
President of Outlook Eyewear Company.

                                       53


<PAGE>



     Reid S. Perper has been a Principal of DLJ Merchant Banking, Inc. since
January 1996. Prior to that time, Mr. Perper had been a Vice President of DLJ
Merchant Banking, Inc. since January 1993. Mr. Perper was formerly a director of
IVAC Holdings, Inc. and Fiberite Holdings, Inc.

     Douglas E. Rogers has been Managing Director of Global Health Care
Partners, a group of DLJ Merchant Banking, Inc. since 1996. Previously, Mr.
Rogers was Vice President at Kidder Peabody & Co., Senior Vice President at
Lehman Brothers, and head of U.S. Investment Banking at Baring Brothers. Mr.
Rogers serves as a director of Computerized Medical Systems, Inc. and Wilson
Greatbatch Ltd.


     William Waltrip has been a director of Bausch & Lomb Incorporated since
1985, and Chairman of the Board of Directors of Technology Solutions Company
since 1993. He has also been a director of Teachers Insurance and Annuity
Association since 1980 and Thomas & Betts Corporation and Technology Solutions
Company since 1983. Previously, Mr. Waltrip served as Chairman and Chief
Executive Officer of Bausch & Lomb Incorporated, as Chief Executive Officer of
Technology Solutions Company, as Chairman and Chief Executive Officer of Biggers
Brothers, Inc., and as Chief Operating Officer of IU International Corporation.
He was also previously President and Chief Executive Officer and a director of
Purolator Courier Corporation


     Henry C. Wendt has been the Chairman of Global Health Care Partners, a
group of DLJ Merchant Banking, Inc. since 1996. Previously, Mr. Wendt was
Chairman of SmithKline Beecham Corporation and President and Chief Executive
Officer of SmithKline Beckman Corp. prior to its merger with Beecham and served
as founder and First Chairman of Pharmaceutical Partners for Better Health Care.
Mr. Wendt serves as a director of Allergen, Inc., Atlantic Richfield Company,
Computerized Medical Systems, The Egypt Investment Company, West Marine Products
and Wilson Greatbatch Ltd.

                                       54


<PAGE>



                             EXECUTIVE COMPENSATION

     The aggregate remuneration of our chief executive officer during 1998 and
the four other most highly compensated executive officers whose salary and bonus
exceeded $100,000 for the fiscal year ended December 26, 1998, is set forth in
the following table:

                           Summary Compensation Table

<TABLE>

                                                                               Long Term
                                                                             Compensation
                                                                       ------------------------
                                                                       Restricted    Securities
                                                                          Stock      Underlying    All Other
Name and Principal Position                      Annual                 Awards(s)     Options     Compensation
- --------------------------------------    -------------------          ----------    ----------   ------------
                                          Salary        Bonus
                                           -----        -----
<S>                                       <C>           <C>              <C>           <C>           <C>
James C. Foster........................   $308,700      $230,705(1)      4,500        19,000      $204,985(2)
   Director, President and Chief
      Executive Officer
Real H. Renaud.........................    212,000      99,814            --           4,200        64,834(3)
   Senior Vice President and
      General Manager, European
      and North American Animal
      Operations
David P. Johst.........................    146,800      69,911            --           4,200        69,871(4)
   Vice President, Human
      Resources and Administration
Julia D. Palm..........................    165,200      50,829            --           1,720        66,953(5)
   Vice President and General
      Manager, Biotech Products
      and Services
Dennis R. Shaughnessey.................    167,800      79,898            --           4,200        82,056(6)
   Vice President, Corporate
      Development, General
      Counsel and Secretary
</TABLE>
- -------------------

(1)  Includes $12,000 in cash paid to Mr. Foster under Bausch & Lomb's Long Term
     Incentive Plan during 1998.

(2)  Includes employer contribution under our Executive Supplemental Life
     Insurance Retirement Plan and EVA Long-Term Incentive Plan ($168,068) and
     Employee Savings Plan ($3,200), costs associated with a corporate
     automobile ($23,861) and corporate club dues and services ($9,856).

(3)  Includes employer contribution under our Executive Supplemental Life
     Insurance Retirement Plan ($40,075) and Employee Savings Plan ($3,200) and
     costs associated with a corporate automobile ($21,559).

(4)  Includes employer contribution under our Executive Supplemental Life
     Insurance Retirement Plan ($54,982) and Employee Savings Plan ($3,200) and
     costs associated with a corporate automobile ($11,689).

(5)  Includes employer contribution under our Executive Supplemental Life
     Insurance Retirement Plan ($50,691) and Employee Savings Plan ($3,200) and
     costs associated with a corporate automobile ($13,062).

(6)  Includes employer contribution under our Executive Supplemental Life
     Insurance Retirement Plan ($57,956) and Employee Savings Plan ($2,132) and
     costs associated with a corporate automobile ($21,968).

                                       55


<PAGE>



Stock Options

     The following table presents material information regarding options to
acquire shares of Bausch & Lomb's common stock granted to our named executive
officers in 1998.


<TABLE>

                                                   Option Grants in 1998 Fiscal Year


                                             Individual Grants                      Potential Realizable Value
                            ------------------------------------------------                at Assumed
                             Number of   Percent of Total                            Annual Rates of Stock Price
                            Securities       Options                                         Appreciation
                            Underlying     Granted to     Exercise or                     for Option Term(1)
                              Options     Employees in    Base Price  Expiration    ---------------------------------
Name                        Granted(#)   Fiscal Year(%)     ($/Sh)       Date        0%($)     5%($)        10%($)
- -----                       ----------   --------------   ----------  ----------    -----    --------      ---------
<S>                         <C>          <C>              <C>         <C>           <C>       <C>          <C>
James C. Foster.............   19,000         1.36%          50.94      7/27/08       --      608,682      1,542,520
Real H. Renaud..............    4,200         0.30%          50.94      7/27/08       --      134,551        340,978
David P. Johst..............    4,200         0.30%          50.94      7/27/08       --      134,551        340,978
Julia D. Palm...............    1,720         0.12%          50.94      7/27/08       --       55,102        139,639
Dennis R. Shaughnessy.......    4,200         0.30%          50.94      7/27/08       --      134,551        340,978
</TABLE>

- -------------------
(1)  We cannot assure you that the value realized by an optionee will be at or
     near the amount estimated using this model. These amounts rely on assumed
     future stock price movements which management believes cannot be predicted
     with a reliable degree of accuracy. These amounts are based on the
     assumption that the option holders hold the options granted for their full
     term. The column headed "0% ($)" is included to illustrate that the options
     were granted at fair market value and option holders will not recognize any
     gain without an increase in the stock price, which increase benefits all
     shareholders commensurately.

     The following table provides material information related to the number and
value of options exercised during 1998 and the value of options held by the
named executive officers at the end of 1998. On December 26, 1998, the closing
sale price of Bausch & Lomb common stock on NYSE was $58 11/16 .


<TABLE>
                 Aggregated Option Exercises in 1998 Fiscal Year and Fiscal Year-End Option Values

                                                                       Number of Securities
                                                                     Underlying Unexercised    Value of Unexercised
                                                                            Options           In-the-Money Options at
                                           Shares                      at Fiscal Year-End (#)      Year End ($)(2)
                                        Acquired on  Value Realized  -----------------------  --------------------------
Name                                    Exercise (#)   ($)(1)        Exercisable Unexercisable Exercisable Unexercisable
- -----                                  ------------- --------------  ----------- ------------- ----------- -------------
<S>                                     <C>           <C>            <C>         <C>           <C>          <C>
James C. Foster.........................     362         10,238         73,740      37,760       1,244,664     497,373
Real H. Renaud..........................   5,036         82,873         17,696       9,418         257,909     125,719
David P. Johst..........................   3,144         64,194          7,370       8,407         105,561     111,026
Julia D. Palm...........................   1,880         39,600          3,214       4,267          60,463      64,727
Dennis R. Shaughnessy...................   6,890         54,303          1,650       8,350          15,469     109,697
</TABLE>
- -------------------


                                       56


<PAGE>



(1)  Value realized represents the difference between the exercise price of the
     option shares and the market price of the option shares on the date the
     option was exercised. The value realized was determined without
     consideration for any issues or brokerage expenses which may have been
     owed.

(2)  Represents the total gain which would be realized if all in-the-money
     options held at year end were exercised, determined by multiplying the
     number of shares underlying the options by the difference between the per
     share option exercise price and the per share fair market value on December
     26, 1998.

Employee Agreements and Compensation Arrangements

     We do not currently have employment agreements with any of our named
executive officers.

Director Compensation

     We intend to pay our independent directors $10,000 per year and $1,000 per
board meeting, plus travel expenses.

                                       57


<PAGE>



         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT


     All of our common stock is held by Charles River Laboratories Holdings. The
following table sets forth certain information with respect to the beneficial
ownership of Holdings common stock by (a) any person or group who beneficially
owns more than five percent of Holdings common stock, (b) each of our directors
and executive officers and (c) all directors and officers as a group.


<TABLE>

                                                                             Percentage of
                                                                              Outstanding
Name of Beneficial Owner:                                                   Common Stock(1)
- ------------------------                                                    ---------------
<S>                                                                            <C>
DLJ Merchant Banking Partners II, L.P. and related investors(2)(3).........     71.9%
Bausch & Lomb Incorporated.................................................     12.5%
James C. Foster(4).........................................................      2.0%
Real H. Renaud(4)..........................................................        *
Thomas F. Ackerman(4)......................................................        *
David P. Johst(4)..........................................................        *
Dr. Charn Sun Lee(4).......................................................        *
Julia D. Palm(4)...........................................................        *
Dennis R. Shaughnessy(4)...................................................        *
Dr. Jorg M. Geller(4)......................................................        *
Gilbert M. Slater(4).......................................................        *
Robert Cawthorn(5).........................................................       --
Stephen D. Chubb...........................................................       --
Thompson Dean(5)...........................................................       --
Stephen C. McCluski........................................................       --
Reid S. Perper(5)..........................................................       --
Douglas E. Rogers(5).......................................................       --
William Waltrip............................................................       --
Henry C. Wendt(5)..........................................................       --
Officers and directors as a group(4).......................................      6.1%
</TABLE>

- -------------------
* less than 1%.

(1)  Under the SEC's rules, each person or entity is deemed to be a beneficial
     owner with the power to vote and direct the disposition of these shares.

(2)  Consists of shares held indirectly through CRL Acquisition LLC by the DLJMB
     Funds and the following related investors: DLJ Merchant Banking Partners
     II-A, L.P.; DLJ Investment Partners, L.P.; DLJ Offshore Partners II, C.V.;
     DLJ Capital Corp.; DLJ Diversified Partners, L.P.; DLJ Diversified
     Partners-A, L.P.; DLJ Millennium Partners, L.P.; DLJ Millennium Partners-A,
     L.P.; DLJMB Funding II, Inc.; DLJ First ESC L.P.; DLJ EAB Partners, L.P.;
     DLJ ESC II, L.P.; Sprout Capital VIII, L.P. and Sprout Venture Capital,
     L.P. See "Certain Relationships and Related Party Transactions" and "Plan
     of Distribution." The address of each of these investors is 277 Park
     Avenue, New York, New York 10172, except the address of Offshore Partners
     is John B. Gorsiraweg 14, Willemstad, Curacao, Netherlands Antilles.

(3)  Does not include the effect of warrants issued previously with the old
     notes or in connection with the issuance by Holdings of senior discount
     debentures with warrants to the DLJMB Funds and other investors. If such
     warrants were exercised, the percentage of outstanding common stock
     beneficially owned by DLJ Merchant Banking Partners II, L.P. and related
     investors would decrease by 1.0%.

(4)  Consists of shares held indirectly through CRL Acquisition LLC.

                                       58


<PAGE>



(5)  Messrs. Cawthorn, Dean, Perper, Rogers and Wendt are officers of DLJ
     Merchant Banking, Inc., an affiliate of the DLJMB Funds and the initial
     purchaser. Shares shown for Messrs. Cawthorn, Dean, Perper, Rogers and
     Wendt exclude shares shown as held by the DLJMB Funds, as to which they
     disclaim beneficial ownership. The address of each of these investors is
     277 Park Avenue, New York, New York 10172.

              CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS

The Recapitalization

     Financial Advisory Fees and Agreements

     Donaldson, Lufkin & Jenrette Securities Corporation ("DLJ Securities
Corporation"), an affiliate of the DLJMB Funds, acted as financial advisor to us
and was also the initial purchaser of the old notes. We paid customary fees to
DLJ Securities Corporation as compensation for its services as financial advisor
and initial purchaser. DLJ Capital Funding, an affiliate of the DLJMB Funds,
received customary fees and reimbursement of expenses in connection with the
arrangement and syndication of the new credit facility and as a lender
thereunder. The aggregate amount of all fees paid to the DLJ entities in
connection with the Recapitalization and the related financing was approximately
$13.2 million plus out-of-pocket-expenses.

     Pursuant to the investors' agreement described below, for a period of five
years from the date of the investors' agreement, DLJ Securities Corporation or
any of its affiliates will be engaged as the exclusive financial and investment
banking advisor of Holdings. We expect that DLJ Securities Corporation or such
affiliate will receive customary fees for such services rendered and will be
entitled to reimbursement for all reasonable disbursements and out-of-pocket
expenses incurred in connection with such engagement. We expect that any such
arrangement will include provisions for the indemnification of DLJ Securities
Corporation against certain liabilities, including liabilities under the federal
securities laws.

     CRL Acquisition LLC Operating Agreement


     CRL Acquisition LLC, DLJMB Funds, management and certain other investors
entered into an operating agreement in connection with the Recapitalization.
The operating agreement provides, among other things, that any person
acquiring limited liability company units of CRL Acquisition LLC who is
required by the operating agreement or by any other agreement or plan of CRL
Acquisition LLC to become a party to the operating agreement will execute an
agreement to be bound by the operating agreement.


     The terms of the operating agreement restrict transfers of the limited
liability company units of CRL Acquisition LLC by certain investors or
management and certain future limited liability company unit holders parties
thereto. The agreement provides for, among other things:

  o  the ability of the other limited liability company unit holders to
     participate in certain sales of units of CRL Acquisition LLC by the DLJMB
     Funds

  o  the ability of the DLJMB Funds to require the other limited liability
     company unit holders to sell limited liability company units of CRL
     Acquisition LLC in certain circumstances should the DLJMB Funds choose to
     sell any such units owned by them

     The operating agreement also provides that DLJMB Funds has the right to
appoint the three members of the board of directors of CRL Acquisition LLC,
including the chairman.

   Investors' Agreement


     Charles River Laboratories Holdings, CRL Acquisition LLC, CRL Holdings,
Inc. (a subsidiary of B&L), management and certain other investors are parties
to an investors' agreement in connection with the Recapitalization. The
investors' agreement


                                       59


<PAGE>



provides, among other things, that any person acquiring shares of common stock
of Holdings who is required by the investors' agreement or by any other
agreement or plan of Holdings to become a party to the investors' agreement
will execute an agreement to be bound by the investors' agreement.

     The terms of the investors' agreement restrict transfers of the shares of
Charles River Laboratories Holdings' common stock by CRL Holdings Inc.,
management and certain other investors and certain future shareholders parties
thereto. The agreement provides for, among other things:

   o the ability of certain other shareholders to participate in certain sales
     of shares of Charles River Laboratories Holdings by CRL Acquisition LLC or
     its permitted transferees

   o the ability of DLJMB Funds or CRL Acquisition LLC to require the other
     shareholders to sell shares of Charles River Laboratories Holdings in
     certain circumstances should the DLJMB Funds or CRL Acquisition LLC choose
     to sell any such shares owned by them

   o certain registration rights with respect to shares of common stock of
     Charles River Laboratories Holdings, including rights to indemnification
     against certain liabilities, including liabilities under the Securities Act

   o the right of CRL Holdings Inc. to sell to Charles River Laboratories
     Holdings all of the common stock of Charles River Laboratories Holdings
     acquired by it as of the closing date of the Recapitalization and still
     held by it, beginning on the date that substantially all of the debt of
     Charles River Laboratories Holdings and its subsidiaries is either repaid
     or refinanced and such refinanced debt permits it (such right terminates
     upon the occurrence of certain events, including an initial public
     offering, or 12 years from the closing date of the Recapitalization)

   o pre-emptive rights of all the parties, other than CRL Acquisition LLC and
     its permitted transferees, to acquire its pre-emptive portion of Charles
     River Laboratories Holdings common stock in certain instances when
     Charles River Laboratories Holdings proposes to issue common stock

     The investors' agreement also provides that DLJ Merchant Banking Partners
II, L.P. has the right to appoint seven of the nine members of the board of
directors of Charles River Laboratories Holdings, including the chairman.


Transactions with Officers and Directors

     In connection with the Recapitalization, certain of our officers purchased
units of CRL Acquisition LLC, some of whom also borrowed funds up to a maximum
aggregate amount of $1.3 million from DLJ Inc. secured by their units. James C.
Foster borrowed $.3 million and each of Real H. Renaud, Thomas F. Ackerman and
Dennis R. Shaughnessy borrowed approximately $0.2 million. Two weeks after the
consummation of the Recapitalization, the loans matured and were repaid by the
officers, partially with funds borrowed from Charles River up to a maximum
aggregate amount of $.9 million. The loans from Charles River matures in ten
years and interest accrues at the initial rate of the Term Loan B of the new
credit facility. Each loan is secured by units in CRL Acquisition LLC held by
the borrower, 25% of each loan is recourse to the borrower and all proceeds from
the sale of such equity and options will be used to pay down the loan until it
is repaid in full. All payments due under each loan accelerates immediately upon
the termination of the borrower's employment with Charles River for any reason.

                                       60


<PAGE>



                       DESCRIPTION OF NEW CREDIT FACILITY

     The new credit facility was provided by a syndicate of financial
institutions led by DLJ Capital Funding, as sole book runner, lead arranger and
syndication agent. The new credit facility includes a $40.0 million term loan A
facility, a $120.0 million term loan B facility and a $30.0 million revolving
credit facility, which provides for loans and under which up to $15.0 million in
letters of credit may be issued. The term loan A facility matures six years
after the closing date of the facility, the term loan B facility matures eight
years after the closing date of the facility and the revolving facility matures
six years after the closing date of the facility. The revolving credit facility
is subject to a potential, but uncommitted, increase of up to $25 million at our
request at any time prior to such revolving credit facility maturity date. Such
increase will be available only if one or more financial institutions agrees, at
the time of our request, to provide it.

     Loans under the term loan A facility and the revolving facility will bear
interest, at our option, at the alternate base rate or the reserve adjusted
LIBOR rate plus, in each case, applicable margins of 3.00% for LIBOR loans and
1.75% for base rate loans. Loans under the term loan B facility will bear
interest, at our option, at the alternate base rate or the reserve adjusted
LIBOR rate plus, in each case, applicable margins of 3.75% for LIBOR loans and
2.50% for base rate loans. We pay commitment fees in an amount equal to 0.50%
per annum on the daily average unused portion of the revolving credit facility.
Such fees are payable quarterly in arrears and upon the maturity or termination
of the revolving credit facility. Beginning approximately six months after the
closing date of the new credit facility, the applicable margins applicable to
loans under the term loan A facility and the revolving facility and commitment
fees will be determined based on the ratio (the "Leverage Ratio") of
consolidated total debt to consolidated EBITDA (as defined in the new credit
facility) of us and our restricted subsidiaries (as defined in the new credit
facility).

     We will pay a letter of credit fee on the outstanding undrawn amounts of
letters of credit issued under the new credit facility at a rate per year equal
to the margin applicable to LIBOR loans under the revolving facility (in the
case of standby letters of credit) or 1.25% (in the case of commercial letters
of credit), which shall be shared by all lenders participating in the relevant
letters of credit. In addition, we will pay an additional fee to the issuer of
each letter of credit in an amount agreed between us and the issuer.

     The term loan A is subject to the following amortization schedule:

<TABLE>
                                                                 Term Loan
Year                                                         Amortization (%)
- -----                                                        ----------------
<S>                                                                <C>
1............................................................        0%
2............................................................        5
3............................................................       10
4............................................................       20
5............................................................       25
6............................................................       40
</TABLE>

     The term loan B is subject to the following amortization schedule:

<TABLE>


                                                                 Term Loan
Year                                                         Amortization (%)
- -----                                                        ----------------
<S>                                                                 <C>
7............................................................         1%
8............................................................        93
</TABLE>


                                       61


<PAGE>



     The new credit facility is subject to mandatory prepayment:

  o  with the net cash proceeds of the sale or other disposition of any property
     or assets of, or receipt of casualty proceeds by, us or any of our
     restricted subsidiaries, subject to certain exceptions, including an
     exception for reinvestment in our and our restricted subsidiaries'
     business,


  o  with 50% of the net cash proceeds received from the issuance of equity
     securities of Charles River Laboratories Holdings, us or any of our
     restricted subsidiaries (subject to certain exceptions) so long as the
     Leverage Ratio following such payment would exceed 3.5:1,

   o with the net cash proceeds received from issuances of debt securities by
     Charles River Laboratories Holdings, us or any of our restricted
     subsidiaries (subject to certain exceptions) and


   o with 50% of excess cash flow (as defined in the new credit facility) for
     each fiscal year so long as the Leverage Ratio following such payment would
     exceed 3.5:1.

     All mandatory prepayment amounts will be applied first to the prepayment of
the term loans.

     All of our future domestic restricted subsidiaries will be guarantors of
the new credit facility. Our obligations under the new credit facility will be
secured by:

   o all of our stock,

   o all of our existing and after-acquired personal property and all the
     existing and after-acquired personal property of our future domestic
     restricted subsidiaries, including a pledge of all of the equity interests
     of all our future restricted subsidiaries held by us or any of our
     restricted subsidiaries and no more than 65% of the equity interests of any
     foreign restricted subsidiary, and all intercompany debt in our favor,

   o first-priority perfected liens on all of our material existing and
     after-acquired real property fee and leasehold interests, subject to
     customary permitted liens (as defined in the new credit facility), and

   o a negative pledge on all of our and our subsidiaries' assets.

     The new credit facility contains customary covenants and restrictions on
our ability to engage in certain activities, including, but not limited to:

   o limitations on other indebtedness, liens, investments and guarantees,

   o restrictions on dividends and redemptions and payments on subordinated debt
     and

   o restrictions on mergers and acquisitions, sales of assets and leases.


     The new credit facility also contains financial covenants requiring us to
maintain a minimum EBITDA, minimum coverage of interest expense, minimum
coverage of fixed charges and a maximum leverage ratio. The new credit facility
contains customary events of default and a cross-default to indebtedness of
Charles River Laboratories Holdings.


     Borrowings and reimbursement obligations under the new credit facility are
subject to significant conditions, including compliance with certain financial
ratios and the absence of any material adverse change. See "Risk Factors--Risks
relating to our debt."

                                       62


<PAGE>



                              DESCRIPTION OF NOTES

     General

     The old notes were issued, and the new notes will be issued, pursuant to an
indenture between Charles River and State Street Bank and Trust Company, as
trustee. The terms of the notes include those stated in the indenture and those
made part of the indenture by reference to the Trust Indenture Act of 1939, as
amended. The notes are subject to all those terms, and holders of notes are
referred to the indenture and the Trust Indenture Act for a statement thereof.
Copies of the proposed form of indenture and registration rights agreement are
available as set forth below under "--Additional Information."


     The terms of the new notes are identical in all material respects to the
terms of the old notes, except that the new notes will only be guaranteed by CRL
Transaction Company, Inc., a subsidiary of Charles River. The subsidiaries which
guaranteed the old notes have been merged into Charles River. In addition, the
old notes contain transfer restrictions and registration rights and, if the
registration statement relating to this exchange offer is not declared effective
on or prior to 180 days after the closing of the old notes, which was on
September 29, 1999, holders of old notes that have complied with their
obligations under the registration rights agreement will be entitled, subject to
exceptions, to liquidated damages in an amount equal to $0.05 per week per
$1,000 principal amount of notes held by such holder and increasing every 90
days thereafter up to a maximum amount equal to $0.25 per week per $1,000
principal amount of notes until the registration statement is declared
effective.


     The following description is a summary of the material provisions of the
indenture. It is not complete and is qualified in its entirety by reference to
the indenture, including the definitions therein of certain terms used below. We
urge you to read the indenture because it, and not this description, defines
your rights as a holder of the notes.

     The definitions of certain terms used in the following summary are set
forth below under "--Certain Definitions." For purposes of this summary, the
term "Charles River" refers only to Charles River Laboratories, Inc. and not to
any of its Subsidiaries.

     The notes will:

   o be general unsecured obligations of Charles River

   o rank junior in right of payment to all existing and future Senior
     Indebtedness of Charles River, including borrowings under our New Credit
     Facility

   o rank equally in right of payment with any future senior subordinated
     Indebtedness of Charles River

   o rank senior in right of payment to all future subordinated Indebtedness of
     Charles River and

   o be effectively junior to all liabilities of Charles River's subsidiaries

     On a pro forma basis, after giving effect to the Transactions, as of
September 25, 1999, we had outstanding approximately $163.3 million of Senior
Indebtedness and our subsidiaries had $5.2 million of outstanding liabilities,
including trade payables but excluding intercompany obligations. The indenture
will permit Charles River and its Subsidiaries to incur additional Indebtedness,
including Senior Indebtedness, in the future. See "Risk Factors--The notes are
subordinated to our other debt" and "--Certain Covenants--Incurrence of
Indebtedness and Issuance of Preferred Stock."

     As of the date of the indenture, all of our Subsidiaries will be Restricted
Subsidiaries. However, so long as we satisfy the conditions described in the
definition of "Unrestricted Subsidiary," we will be permitted to designate
current or future Subsidiaries as "Unrestricted" Subsidiaries that are not
subject to the restrictive covenants included in the indenture.


                                       63


<PAGE>


Principal, Maturity and Interest

   o The notes will initially be limited in aggregate principal amount to $150.0
     million and will mature on October 1, 2009.

   o The notes will be issued in denominations of $1,000 and integral multiples
     thereof.

   o Interest on the notes will accrue at the rate of 13.5% per year; provided
     that the rate at which interest accrues will increase to 14.0% per year on
     August 15, 2000 in the event that the Ratio of Consolidated Net Debt to
     Consolidated Cash Flow for Charles River as of June 30, 2000 is equal to or
     greater than 5.00 to 1.

   o We will pay interest in arrears every October 1 and April 1, commencing on
     April 1, 2000, to holders of record on the immediately preceding September
     15 and March 15.

   o Interest on the notes will accrue from the most recent date to which
     interest has been paid or, if no interest has been paid, from the date of
     original issuance.

   o Interest will be computed on the basis of a 360-day year comprised of
     twelve 30-day months.

     We will pay principal of, premium, if any, and interest and liquidated
damages, if any, on the notes:

   o at the office or agency we maintain for that purpose within the City and
     State of New York

   o or, at our option, by check mailed to the holders of the notes at their
     respective addresses set forth in the register of holders of notes

   o however, all payments with respect to notes represented by one or more
     permanent Global Notes will be paid by wire transfer of immediately
     available funds to the account of the Depository Trust Company or any
     successor thereto.

     Until we designate another office or agency, our office or agency in New
York will be the office of the trustee maintained for that purpose.

     Subject to the covenants described below, we may issue additional notes
under the indenture having the same terms in all respects as the notes, or
similar in all respects except for the payment of interest on the notes (1)
scheduled and paid prior to the date of issuance of those additional notes or
(2) payable on the first Interest Payment Date following that date of issuance.
The notes offered hereby and any additional notes would be treated as a single
class for all purposes under the indenture.

Subordination

     The payment of Subordinated Note Obligations will be subordinated in right
of payment, as set forth in the indenture, to the prior payment in full in cash
or cash equivalents of all Senior Indebtedness, whether outstanding on the date
of the indenture or thereafter incurred.

     Upon any distribution to creditors of Charles River in a liquidation or
dissolution of Charles River or in a bankruptcy, reorganization, insolvency,
receivership or similar proceeding relating to Charles River or its property, an
assignment for the benefit of creditors or any marshaling of Charles River's
assets and liabilities,

          (1) the holders of Senior Indebtedness will be entitled to receive
     payment in full in cash or cash equivalents of all Obligations due in
     respect of such Senior Indebtedness, including interest after the
     commencement of any such proceeding at the rate specified in the applicable
     Senior Indebtedness, before the holders of notes will be entitled to
     receive any payment with respect to the Subordinated Note Obligations, and

                                       64


<PAGE>



          (2) until all Obligations with respect to Senior Indebtedness are paid
     in full in cash or cash equivalents, any distribution to which the holders
     of notes would be entitled shall be made to the holders of Senior
     Indebtedness.

     However, holders of notes may receive and retain Permitted Junior
Securities and payments made from the trust described under "--Legal Defeasance
and Covenant Defeasance."

     Charles River also may not make any payment upon or in respect of the
Subordinated Note Obligations, except in Permitted Junior Securities or from the
trust described under "--Legal Defeasance and Covenant Defeasance," until all
obligations with respect to Senior Indebtedness have been paid in full in cash
or cash equivalents if:

          (1) a default in the payment of the principal (including reimbursement
     obligations in respect of letters of credit) of, premium, if any, or
     interest on or commitment, letter of credit or administrative fees relating
     to, Designated Senior Indebtedness occurs and is continuing beyond any
     applicable period of grace; or

          (2) any other default occurs and is continuing with respect to
     Designated Senior Indebtedness that permits holders of the Designated
     Senior Indebtedness as to which that default relates to accelerate its
     maturity and the trustee receives a notice of that default (a "Payment
     Blockage Notice") from Charles River or the holders of any Designated
     Senior Indebtedness.

     Payments on the notes may and shall be resumed:

          (1) in the case of a payment default, upon the date on which that
     default is cured or waived; and

          (2) in case of a nonpayment default, the earlier of the date on which
     that nonpayment default is cured or waived or 179 days after the date on
     which the applicable Payment Blockage Notice is received, unless the
     maturity of any Designated Senior Indebtedness has been accelerated.

     No new period of payment blockage may be commenced unless and until 360
days have elapsed since the effectiveness of the immediately prior Payment
Blockage Notice. No nonpayment default that existed or was continuing on the
date of delivery of any Payment Blockage Notice to the trustee shall be, or be
made, the basis for a subsequent Payment Blockage Notice unless that default
shall have been waived or cured for a period of not less than 90 days.

     "Designated Senior Indebtedness" means:

          (1) any Indebtedness outstanding under the New Credit Facility; and

          (2) any other Senior Indebtedness permitted under the indenture the
     principal amount of which is $25.0 million or more and that has been
     designated by Charles River in writing to the trustee as "Designated Senior
     Indebtedness."

     "Permitted Junior Securities" means Equity Interests in Charles River or
debt securities of Charles River that are subordinated to all Senior
Indebtedness and any debt securities issued in exchange for Senior Indebtedness
to substantially the same extent as, or to a greater extent than, the notes are
subordinated to Senior Indebtedness.

     "Senior Indebtedness" means, with respect to any Person:

          (1) all Obligations of that Person outstanding under the New Credit
     Facility and all Hedging Obligations payable to a lender or an Affiliate
     thereof or to a Person that was a lender or an Affiliate thereof at the
     time the contract was entered into under the New Credit Facility or any of
     its Affiliates, including, without limitation, interest accruing subsequent
     to the filing of, or which would have accrued but for the filing of, a
     petition for bankruptcy, whether or not that interest is an allowable claim
     in that bankruptcy proceeding;

                                       65


<PAGE>



          (2) any other Indebtedness, unless the instrument under which that
     Indebtedness is incurred expressly provides that it is subordinated in
     right of payment to any other Senior Indebtedness of that Person; and

          (3) all Obligations with respect to the foregoing.

     Notwithstanding anything to the contrary in the foregoing, Senior
Indebtedness will not include:

               (a) any liability for federal, state, local or other taxes;

               (b) any Indebtedness of that Person, other than pursuant to the
          New Credit Facility, to

     any of its Subsidiaries or other Affiliates;

               (c) any trade payables; or

               (d) any Indebtedness that is incurred in violation of the
          indenture.

     "Subordinated Note Obligations" means all Obligations with respect to the
notes, including, without limitation, principal, premium, if any, interest and
liquidated damages, if any, payable pursuant to the terms of the notes
(including upon the acceleration or redemption thereof), together with and
including any amounts received or receivable upon the exercise of rights of
rescission or other rights of action, including claims for damages, or
otherwise.

     We will promptly notify holders of Senior Indebtedness if payment of the
notes is accelerated because of an Event of Default.

     As a result of the subordination provisions described above, in the event
of a liquidation or insolvency, holders of notes may recover less ratably than
creditors of Charles River who are holders of Senior Indebtedness.

Optional Redemption

     Except as provided below, the notes will not be redeemable at Charles
River's option prior to October 1, 2004. Thereafter, the notes will be subject
to redemption at any time at the option of Charles River, in whole or in part,
upon not less than 30 nor more than 60 days' notice, in cash at the redemption
prices (expressed as percentages of principal amount) set forth below, plus
accrued and unpaid interest and liquidated damages, if any, thereon to the
applicable redemption date, if redeemed during the twelve-month period beginning
on October 1 of the years indicated below:

<TABLE>

Year                                                   Percentage
- ----                                                   ----------
<S>                                                    <C>
2004.................................................. 106.750%
2005.................................................. 104.500%
2006.................................................. 102.250%
2007 and thereafter................................... 100.000%
</TABLE>

     Notwithstanding the foregoing, on or prior to October 1, 2002, Charles
River may redeem up to 35% of the aggregate principal amount of notes from time
to time originally issued under the indenture in cash at a redemption price of
113.500% of the principal amount thereof, plus accrued and unpaid interest and
liquidated damages, if any, thereon to the redemption date, with the net cash
proceeds of one or more Public Equity Offerings; provided that:

          (1) at least 65% of the aggregate principal amount of notes from time
     to time originally issued under the indenture remains outstanding
     immediately after the occurrence of the redemption; and

                                       66


<PAGE>



          (2) the redemption shall occur within 90 days of the date of the
     closing of any such Public Equity Offering.

Selection and Notice

     If less than all of the notes are to be redeemed at any time, the trustee
will select the notes for redemption as follows:

          (1) in compliance with the requirements of the principal national
     securities exchange, if any, on which the notes are listed; or

          (2) if the notes are not so listed, on a pro rata basis, by lot or by
     another method the trustee considers fair and appropriate;

     provided that no notes of $1,000 or less shall be redeemed in part.

     Notices of redemption shall be mailed by first class mail at least 30 but
not more than 60 days before the redemption date to each holder of notes to be
redeemed at its registered address. Notices of redemption may not be
conditional.

     If any note is to be redeemed in part only, the notice of redemption that
relates to that note shall state the portion of the principal amount thereof to
be redeemed. A new note in principal amount equal to the unredeemed portion
thereof will be issued in the name of the holder thereof upon cancellation of
the original note. Notes called for redemption become due on the date fixed for
redemption. On and after the redemption date, interest ceases to accrue on notes
or portions of them called for redemption.

Mandatory Redemption

     Charles River is not required to make mandatory redemption of, or sinking
fund payments with respect to, the notes.

Repurchase at the Option of Holders

     Change of Control

     Upon the occurrence of a Change of Control, each holder of notes will have
the right to require Charles River to repurchase all or any part (equal to
$1,000 or an integral multiple thereof) of that holder's notes pursuant to the
offer described below (the "Change of Control Offer") at an offer price in cash
equal to 101% of the aggregate principal amount thereof, plus accrued and unpaid
interest and liquidated damages, if any, thereon to the date of repurchase (the
"Change of Control Payment"). Within 60 days following any Change of Control,
Charles River will, or will cause the trustee to, mail a notice to each holder
describing the transaction or transactions that constitute the Change of Control
and offering to repurchase notes on the date specified in that notice, which
date shall be no earlier than 30 days and no later than 60 days from the date
that notice is mailed (the "Change of Control Payment Date"), pursuant to the
procedures required by the indenture and described in that notice. Charles River
will comply with the requirements of Rule 14e-1 under the Exchange Act and any
other securities laws and regulations thereunder to the extent those laws and
regulations are applicable in connection with the repurchase of the notes as a
result of a Change of Control. To the extent that the provisions of any
securities laws or regulations conflict with the provisions of the indenture
relating to a Change of Control Offer, Charles River will comply with the
applicable securities laws and regulations and shall not be deemed to have
breached its obligations described in the indenture by virtue thereof.

     On the Change of Control Payment Date, Charles River will, to the extent
lawful:

          (1) accept for payment all notes or portions thereof properly tendered
     pursuant to the Change of Control Offer;

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          (2) deposit with the Paying Agent an amount equal to the Change of
     Control Payment in respect of all notes or portions thereof so tendered;
     and

          (3) deliver or cause to be delivered to the trustee the notes so
     accepted together with an Officers' Certificate stating the aggregate
     principal amount of notes or portions thereof being purchased by Charles
     River.

     The Paying Agent will promptly mail to each holder of notes so tendered the
Change of Control Payment for that holder's notes, and the trustee will promptly
authenticate and mail or cause to be transferred by book-entry to each holder a
new note equal in principal amount to any unpurchased portion of the notes
surrendered, if any; provided that each new note will be in a principal amount
of $1,000 or an integral multiple thereof.

     The indenture will provide that, prior to complying with the provisions of
this covenant, but in any event within 90 days following a Change of Control,
Charles River will either repay all outstanding Senior Indebtedness or obtain
the requisite consents, if any, under all agreements governing outstanding
Senior Indebtedness to permit the repurchase of notes required by this covenant.
The indenture requires Charles River to publicly announce the results of the
Change of Control Offer on or as soon as practicable after the Change of Control
Payment Date.

     The Change of Control provisions described above will be applicable whether
or not any other provisions of the indenture are applicable. Except as described
above with respect to a Change of Control, the indenture does not contain
provisions that permit the holders of the notes to require that Charles River
repurchase or redeem the notes in the event of a takeover, recapitalization or
similar transaction.

     The New Credit Facility will prohibit Charles River from purchasing any
notes and also will provide that certain change of control events, which may
include events not otherwise constituting a Change of Control under the
indenture, with respect to Charles River would constitute a default thereunder.
Any future credit agreements or other agreements relating to Senior Indebtedness
to which Charles River becomes a party may contain similar restrictions and
provisions. In the event a Change of Control occurs at a time when Charles River
is prohibited from purchasing notes, Charles River could seek the consent of its
lenders to the purchase of notes or could attempt to refinance the borrowings
that contain that prohibition. If Charles River does not obtain such a consent
or repay those borrowings, Charles River will remain prohibited from purchasing
notes. In that case, Charles River's failure to purchase tendered notes would
constitute an Event of Default under the indenture, which would, in turn,
constitute a default under the New Credit Facility. In those circumstances, the
subordination provisions in the indenture would likely restrict payments to the
holders of notes.

     Charles River will not be required to make a Change of Control Offer upon a
Change of Control if a third party makes the Change of Control Offer in the
manner, at the times and otherwise in compliance with the requirements set forth
in the indenture applicable to a Change of Control Offer made by Charles River
and purchases all notes validly tendered and not withdrawn under that Change of
Control Offer.

     "Change of Control" means the occurrence of any of the following:

          (1) the sale, lease, transfer, conveyance or other disposition, other
     than by way of merger or consolidation, in one or a series of related
     transactions, of all or substantially all of the assets of Charles River
     and its Subsidiaries, taken as a whole, to any "person" or "group" (as
     those terms are used in Section 13(d) of the Exchange Act), other than the
     Principals and their Related Parties;

          (2) the adoption of a plan for the liquidation or dissolution of
     Charles River;

          (3) the consummation of any transaction, including, without
     limitation, any merger or consolidation, the result of which is that any
     "person" or "group" (as those terms are used in Section 13(d) of the
     Exchange Act), other than the Principals and their Related Parties, becomes
     the "beneficial owner" (as that term is defined in Rule 13d-3 and Rule
     13d-5 under the Exchange Act), directly or indirectly through one or more
     intermediaries, of 50% or more of the voting power of the outstanding
     voting stock of Charles River; or

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          (4) the first day on which a majority of the members of the board of
     directors of Charles River are not Continuing Members.

     The definition of Change of Control includes a phrase relating to the sale,
lease, transfer, conveyance or other disposition of "all or substantially all"
of the assets of Charles River and its Subsidiaries taken as a whole. Although
there is a developing body of case law interpreting the phrase "substantially
all," there is no precise established definition of the phrase under applicable
law. Accordingly, the ability of a holder of notes to require Charles River to
repurchase notes as a result of a sale, lease, transfer, conveyance or other
disposition of less than all of the assets of Charles River and its Subsidiaries
taken as a whole to another person or group may be uncertain.

     "Continuing Members" means, as of any date of determination, any member of
the board of directors of Charles River who:

          (1) was a member of Charles River's board of directors immediately
     after consummation of the Recapitalization and the Recapitalization
     Financing; or

          (2) was nominated for election or elected to Charles River's board of
     directors with the approval of, or whose election to the board of directors
     was ratified by, at least a majority of the Continuing Members who were
     members of Charles River's board of directors at the time of that
     nomination or election.

Certain Covenants

      Asset Sales

     The indenture will provide that Charles River will not, and will not permit
any of its Restricted Subsidiaries to, consummate an Asset Sale unless:

          (1) Charles River or the Restricted Subsidiary, as the case may be,
     receives consideration at the time of that Asset Sale at least equal to the
     fair market value (evidenced by a resolution of the board of directors set
     forth in an Officers' Certificate delivered to the trustee) of the assets
     or Equity Interests issued or sold or otherwise disposed of; and

          (2) at least 75% of the consideration therefor received by Charles
     River or the Restricted Subsidiary is in the form of:

               (a) cash or Cash Equivalents; or

               (b) property or assets that are used or useful in a Permitted
          Business, or the Capital Stock of any Person engaged in a Permitted
          Business if, as a result of the acquisition by Charles River or any
          Restricted Subsidiary thereof, that Person becomes a Restricted
          Subsidiary.

     For the purposes of this provision, each of the following shall be deemed
to be cash:

               (i) any liabilities, as shown on Charles River's or the
          Restricted Subsidiary's most recent balance sheet, of Charles River or
          any Restricted Subsidiary (other than contingent liabilities and
          liabilities that are by their terms subordinated to the notes or any
          guarantee thereof) that are assumed by the transferee of any such
          assets pursuant to a customary novation agreement that releases
          Charles River or the Restricted Subsidiary from further liability;

               (ii) any securities, notes or other obligations received by
          Charles River or the Restricted Subsidiary from the transferee
          that are converted within 180 days of their receipt by Charles
          River or the Restricted Subsidiary by Charles River or the
          Restricted Subsidiary into cash or Cash Equivalents, but only to
          the extent of the cash or Cash Equivalents received; and

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                (iii) any Designated Noncash Consideration received by
           Charles River or any of its Restricted Subsidiaries in that Asset
           Sale having an aggregate fair market value, taken together with
           all other Designated Noncash Consideration received pursuant to
           this clause (iii) that is at that time outstanding, not to exceed
           15% of Total Assets at the time of the receipt of that Designated
           Noncash Consideration, with the fair market value of each item of
           Designated Noncash Consideration being measured at the time
           received and without giving effect to subsequent changes in
           value.

     The 75% limitation referred to in clause (2) above will not apply to any
Asset Sale in which the cash or Cash Equivalents portion of the consideration
received therefrom, determined in accordance with subclauses (i), (ii) and (iii)
above, is equal to or greater than what the after-tax proceeds would have been
had that Asset Sale complied with the aforementioned 75% limitation.

     Within 365 days after the receipt of any Net Proceeds from an Asset Sale,
Charles River or the Restricted Subsidiary, as the case may be, shall apply the
Net Proceeds, at its option (or to the extent Charles River is required to apply
the Net Proceeds pursuant to the terms of the New Credit Facility), to:

          (1) repay or purchase Senior Indebtedness or Pari Passu Indebtedness
     of Charles River or any Indebtedness of any Restricted Subsidiary, as the
     case may be,

     provided that if Charles River shall so repay or purchase Pari Passu
Indebtedness of Charles River;

               (a) it will equally and ratably reduce Indebtedness under the
          notes if the notes are then redeemable; or

               (b) if the notes may not then be redeemed, Charles River shall
          make an offer, in accordance with the procedures set forth below for
          an Asset Sale Offer, to all holders of notes to purchase at a purchase
          price equal to 100% of the principal amount of the notes, plus accrued
          and unpaid interest and liquidated damages, if any, thereon to the
          date of purchase, the notes that would otherwise be redeemed; or

          (2)(a) an investment in property, the making of a capital expenditure
     or the acquisition of assets that are used or useful in a Permitted
     Business; or

               (b) the acquisition of Capital Stock of any Person primarily
     engaged in a Permitted Business if:

                    (x) as a result of the acquisition by Charles River or any
               Restricted Subsidiary thereof, that Person becomes a Restricted
               Subsidiary; or

                    (y) the Investment in that Capital Stock is permitted by
               clause (6) of the definition of Permitted Investments.

     Pending the final application of any Net Proceeds, Charles River may
temporarily reduce Indebtedness or otherwise invest those Net Proceeds in any
manner that is not prohibited by the indenture.

     Any Net Proceeds from Asset Sales that are not applied or invested as
provided in the first sentence of the second preceding paragraph will be deemed
to constitute "Excess Proceeds." When the aggregate amount of Excess Proceeds
exceeds $10.0 million, Charles River will be required to make an offer to all
holders of notes (an "Asset Sale Offer") to purchase the maximum principal
amount of notes that may be purchased out of the Excess Proceeds, at an offer
price in cash in an amount equal to 100% of the principal amount thereof, plus
accrued and unpaid interest and liquidated damages, if any, thereon to the date
of purchase, in accordance with the procedures set forth in the indenture.

     To the extent that any Excess Proceeds remain after consummation of an
Asset Sale Offer, Charles River may use those Excess Proceeds for any purpose
not otherwise prohibited by the indenture. If the aggregate principal amount of
notes surrendered by holders thereof in connection with an Asset Sale Offer
exceeds the amount of Excess Proceeds, the

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trustee shall select the notes to be purchased as set forth under "--Selection
and Notice." Upon completion of an offer to purchase, the amount of Excess
Proceeds shall be reset at zero.

     Charles River will comply with the requirements of Rule 14e-1 under the
Exchange Act and any other securities laws and regulations thereunder to the
extent those laws and regulations are applicable in connection with the
repurchase of the notes pursuant to an Asset Sale Offer. To the extent that the
provisions of any securities laws or regulations conflict with the provisions of
the indenture relating to an Asset Sale Offer, Charles River will comply with
the applicable securities laws and regulations and shall not be deemed to have
breached its obligations described in the indenture by virtue thereof.

     Restricted Payments

     The indenture will provide that Charles River will not, and will not permit
any of its Restricted Subsidiaries to, directly or indirectly:

          (1) declare or pay any dividend or make any other payment or
     distribution on account of Charles River's or any of its Restricted
     Subsidiaries' Equity Interests other than

   o dividends or distributions payable in Equity Interests other than
     Disqualified Stock of Charles River or

   o dividends or distributions payable to Charles River or any Wholly Owned
     Restricted Subsidiary of Charles River;

          (2) purchase, redeem or otherwise acquire or retire for value any
     Equity Interests of Charles River or Parent other than any of those Equity
     Interests owned by Charles River or any Restricted Subsidiary of Charles
     River;

          (3) make any principal payment on or with respect to, or purchase,
     redeem, defease or otherwise acquire or retire for value, any Indebtedness
     of Charles River that is subordinated in right of payment to the notes,
     except in accordance with the mandatory redemption or repayment provisions
     set forth in the original documentation governing that Indebtedness (but
     not pursuant to any mandatory offer to repurchase upon the occurrence of
     any event); or

          (4) make any Restricted Investment

(all payments and other actions set forth in clauses (1) through (4) above being
collectively referred to as "Restricted Payments"),

unless, at the time of and after giving effect to that Restricted Payment:

          (1) no Default or Event of Default shall have occurred and be
     continuing or would occur as a consequence thereof;

          (2) Charles River would, immediately after giving pro forma effect
     thereto as if that Restricted Payment had been made at the beginning of the
     applicable four-quarter period, have been permitted to incur at least $1.00
     of additional Indebtedness pursuant to the Fixed Charge Coverage Ratio test
     set forth in the first paragraph of the covenant described under the
     caption "--Incurrence of Indebtedness and Issuance of Preferred Stock"; and

          (3) that Restricted Payment, together with the aggregate amount of all
     other Restricted Payments made by Charles River and its Restricted
     Subsidiaries after the date of the indenture (excluding Restricted Payments
     permitted by clauses (1) (to the extent that the declaration of any
     dividend referred to therein reduces amounts available for Restricted
     Payments pursuant to this clause (3)), (2) through (9), (11) through (15)
     and (17) of the next succeeding paragraph), is less than the sum, without
     duplication, of:

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          (a) 50% of the Consolidated Net Income of Charles River for the period
     (taken as one accounting period) commencing June 27, 1999 to the end of
     Charles River's most recently ended fiscal quarter for which internal
     financial statements are available at the time of that Restricted Payment
     (or, if Consolidated Net Income for that period is a deficit, less 100% of
     the deficit); plus

          (b) 100% of the Qualified Proceeds received by Charles River on or
     after the date of the indenture from contributions to Charles River's
     capital or from the issue or sale on or after the date of the indenture of
     Equity Interests of Charles River or of Disqualified Stock or convertible
     debt securities of Charles River to the extent that they have been
     converted into those Equity Interests, other than

       o  Equity Interests, Disqualified Stock or convertible debt securities
          sold to a Subsidiary of Charles River and

       o  Disqualified Stock or convertible debt securities that have been
          converted into Disqualified Stock; plus

     (c) the amount equal to the net reduction in Investments in Persons after
the date of the indenture who are not Restricted Subsidiaries (other than
Permitted Investments) resulting from:

          (i)  Qualified Proceeds received as a dividend, repayment of a loan or
               advance or other transfer of assets (valued at the fair market
               value thereof) to Charles River or any Restricted Subsidiary from
               those Persons;

          (ii) Qualified Proceeds received upon the sale or liquidation of those
               Investments; and

          (iii) the redesignation of Unrestricted Subsidiaries (excluding any
               increase in the amount available for Restricted Payments pursuant
               to clause (10) or (14) below arising from the redesignation of
               that Unrestricted Subsidiary) whose assets are used or useful in,
               or which is engaged in, one or more Permitted Business as
               Restricted Subsidiaries (valued, proportionate to Charles River's
               equity interest in that Subsidiary, at the fair market value of
               the net assets of that Subsidiary at the time of that
               redesignation).

     The foregoing provisions will not prohibit:

     (1) the payment of any dividend within 60 days after the date of
declaration thereof, if at said date of declaration, the payment would have
complied with the provisions of the indenture;

     (2) the redemption, repurchase, retirement, defeasance or other acquisition
of any subordinated Indebtedness or Equity Interests of Charles River in
exchange for, or out of the net cash proceeds of the substantially concurrent
sale (other than to a Subsidiary of Charles River) of other Equity Interests of
Charles River (other than any Disqualified Stock), provided that the amount of
any such net cash proceeds that are utilized for any such redemption,
repurchase, retirement, defeasance or other acquisition shall be excluded from
clause (3)(b) of the preceding paragraph;

     (3) the defeasance, redemption, repurchase, retirement or other acquisition
of subordinated Indebtedness of Charles River with the net cash proceeds from an
incurrence of, or in exchange for, Permitted Refinancing Indebtedness;

     (4) the repurchase, redemption or other acquisition or retirement for value
of any Equity Interests of Charles River or Parent or CRL Acquisition LLC held
by any member of Parent's, Charles River's (or any of its Restricted
Subsidiaries') management pursuant to any management equity subscription
agreement or stock option agreement and any dividend to Parent to fund any such
repurchase, redemption acquisition or retirement; provided that:

          (a) the aggregate price paid for all such repurchased, redeemed,
     acquired or retired Equity Interests shall not exceed:

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               (i)  $5.0 million in any calendar year, with unused amounts in
                    any calendar year being carried over to succeeding calendar
                    years subject to a maximum (without giving effect to the
                    following clause (ii)) of $10.0 million in any calendar
                    year; plus

               (ii) the aggregate net cash proceeds received by Charles River
                    during that calendar year from any reissuance of Equity
                    Interests by Charles River, Parent or CRL Acquisition LLC to
                    members of management of Charles River and its Restricted
                    Subsidiaries; provided that the amount of any such net cash
                    proceeds that are used to permit an acquisition or
                    retirement for value pursuant to this clause (4) shall be
                    excluded from clause (3)(b) of the preceding paragraph; and

          (b) no Default or Event of Default shall have occurred and be
     continuing immediately after that transaction;

     (5)   payments and transactions in connection with

       o  the Transactions, including any purchase price adjustment or any other
          payments made pursuant to or as contemplated in the Transaction
          Agreements or the financial advisory agreements with DLJ Securities
          Corporation described under "Certain Relationships and Related Party
          Transactions,"

       o  the Transaction Financing,

       o  the Offering,

       o  the New Credit Facility (including commitment, syndication and
          arrangement fees payable thereunder) and

       o  the application of the proceeds thereof, and the payment of fees and
          expenses with respect thereto;

     (6) the payment of dividends or the making of loans or advances by Charles
River to Parent not to exceed $2.5 million in any fiscal year for costs and
expenses incurred by Parent in its capacity as a holding company for services
rendered by Parent on behalf of Charles River;

     (7) payments or distributions to Parent pursuant to any Tax Sharing
Agreement;

     (8) the payment of dividends by a Restricted Subsidiary on any class of
common stock of that Restricted Subsidiary if:

          (a)   that dividend is paid pro rata to all holders of that class of
     common stock; and

          (b) at least 50.1% of that class of common stock is held by Charles
     River or one or more of its Restricted Subsidiaries;

     (9) the repurchase of any class of common stock of a Restricted Subsidiary
if:

          (a) that repurchase is made pro rata with respect to that class of
     common stock; and

          (b) at least 50.1% of that class of common stock is held by Charles
     River or one or more of its Restricted Subsidiaries;

     (10) any other Restricted Investment made in a Permitted Business which,
together with all other Restricted Investments made pursuant to this clause (10)
since the date of the indenture, does not exceed $5.0 million (in each case,
after giving effect to all subsequent reductions in the amount of any Restricted
Investment made pursuant to this clause (10), either as a result of (i) the
repayment or disposition thereof for cash or (ii) the redesignation of an
Unrestricted Subsidiary as a Restricted Subsidiary (valued, proportionate to
Charles River's equity interest in that Subsidiary at the time of that
redesignation, at the fair market value of the net assets of that Subsidiary at
the time of

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that redesignation), in the case of clause (i) and (ii), not to exceed the
amount of the Restricted Investment previously made pursuant to this clause
(10); provided that no Default or Event of Default shall have occurred and be
continuing immediately after making that Restricted Investment;

    (11) the declaration and payment of dividends to holders of any class or
series of Disqualified Stock of Charles River or any Restricted Subsidiary
issued on or after the date of the indenture in accordance with the covenant
described under the caption "--Incurrence of Indebtedness and Issuance of
Preferred Stock;" provided that no Default or Event of Default shall have
occurred and be continuing immediately after making that Restricted Payment;

    (12) repurchases of Equity Interests deemed to occur upon exercise of stock
options if those Equity Interests represent a portion of the exercise price of
those options;

    (13) any other Restricted Payment which, together with all other Restricted
Payments made pursuant to this clause (13) since the date of the indenture, does
not exceed $5.0 million, in each case, after giving effect to all subsequent
reductions in the amount of any Restricted Investment made pursuant to this
clause (13) either as a result of (i) the repayment or disposition thereof for
cash or (ii) the redesignation of an Unrestricted Subsidiary as a Restricted
Subsidiary (valued, proportionate to Charles River's equity interest in that
Subsidiary at the time of that redesignation, at the fair market value of the
net assets of that Subsidiary at the time of that redesignation), in the case of
clause (i) and (ii), not to exceed the amount of the Restricted Investment
previously made pursuant to this clause (13); provided that no Default or Event
of Default shall have occurred and be continuing immediately after making that
Restricted Payment;

    (14) the pledge by Charles River of the Capital Stock of an Unrestricted
Subsidiary of Charles River to secure Non-Recourse Debt of that Unrestricted
Subsidiary;

    (15) the purchase, redemption or other acquisition or retirement for value
of any Equity Interests of any Restricted Subsidiary issued after the date of
the indenture, provided that the aggregate price paid for any such repurchased,
redeemed, acquired or retired Equity Interests shall not exceed the sum of:

          (a) the amount of cash and Cash Equivalents received by that
      Restricted Subsidiary from the issue or sale thereof; and

          (b) any accrued dividends thereon the payment of which would be
      permitted pursuant to clause (11) above;

    (16) any Investment in an Unrestricted Subsidiary that is funded by
Qualified Proceeds received by Charles River on or after the date of the
indenture from contributions to Charles River's capital or from the issue and
sale on or after the date of the indenture of Equity Interests of Charles River
or of Disqualified Stock or convertible debt securities to the extent they have
been converted into that Equity Interests (other than Equity Interests,
Disqualified Stock or convertible debt securities sold to a Subsidiary of
Charles River and other than Disqualified Stock or convertible debt securities
that have been converted into Disqualified Stock) in an amount (measured at the
time that Investment is made and without giving effect to subsequent changes in
value) that does not exceed the amount of those Qualified Proceeds (excluding
any such Qualified Proceeds to the extent utilized to permit a prior "Restricted
Payment" pursuant to clause (3)(b) of the preceding paragraph); and

    (17) distributions or payments of Receivables Fees.

     The board of directors of Charles River may designate any Restricted
Subsidiary to be an Unrestricted Subsidiary if that designation would not cause
a Default. For purposes of making that designation, all outstanding Investments
by Charles River and its Restricted Subsidiaries (except to the extent repaid in
cash) in the Subsidiary so designated will be deemed to be Restricted Payments
at the time of that designation and will reduce the amount available for
Restricted Payments under the first paragraph of this covenant. All such
outstanding Investments will be deemed to constitute Restricted Investments in
an amount equal to the greater of

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     (1)   the net book value of that Investments at the time of that
designation and

     (2) the fair market value of that Investments at the time of that
designation.

     That designation will only be permitted if that Restricted Investment would
be permitted at that time and if that Restricted Subsidiary otherwise meets the
definition of an Unrestricted Subsidiary.

     The amount of

     (1) all Restricted Payments (other than cash) shall be the fair market
value on the date of the Restricted Payment of the asset(s) or securities
proposed to be transferred or issued by Charles River or that Restricted
Subsidiary, as the case may be, pursuant to the Restricted Payment and

     (2) Qualified Proceeds (other than cash) shall be the fair market value on
the date of receipt thereof by Charles River of those Qualified Proceeds.

     The fair market value of any non-cash Restricted Payment shall be
determined by the board of directors of Charles River whose resolution with
respect thereto shall be delivered to the trustee.

     Not later than the date of making any Restricted Payment, Charles River
shall deliver to the trustee an Officers' Certificate stating that the
Restricted Payment is permitted and setting forth the basis upon which the
calculations required by the covenant "Restricted Payments" were computed.

     Incurrence of Indebtedness and Issuance of Preferred Stock

     The indenture will provide that:

     (1) Charles River will not, and will not permit any of its Restricted
Subsidiaries to, directly or indirectly, create, incur, issue, assume, guarantee
or otherwise become directly or indirectly liable, contingently or otherwise,
with respect to (collectively, "incur") any Indebtedness (including Acquired
Indebtedness);

     (2) Charles River will not, and will not permit any of its Restricted
Subsidiaries to, issue any shares of Disqualified Stock; and

     (3)   Charles River will not permit any of its Restricted Subsidiaries to
issue any shares of preferred stock;

provided that Charles River or any Restricted Subsidiary may incur Indebtedness,
including Acquired Indebtedness, or issue shares of Disqualified Stock if the
Fixed Charge Coverage Ratio for Charles River's most recently ended four full
fiscal quarters for which internal financial statements are available
immediately preceding the date on which that additional Indebtedness is incurred
or that Disqualified Stock is issued would have been at least 2.0 to 1 if such
four-quarter period ended prior to September 30, 2002 and 2.25 to 1 thereafter,
determined on a consolidated pro forma basis, including a pro forma application
of the net proceeds therefrom, as if the additional Indebtedness had been
incurred, or the Disqualified Stock had been issued, as the case may be, at the
beginning of that four-quarter period.

     The provisions of the first paragraph of this covenant will not apply to
the incurrence of any of the following items of Indebtedness (collectively,
"Permitted Indebtedness"):

     (1) the incurrence by Charles River and its Restricted Subsidiaries of
Indebtedness under the New Credit Facility and the Foreign Credit Facilities;
provided that the aggregate principal amount of all Indebtedness (with letters
of credit being deemed to have a principal amount equal to the maximum potential
liability of Charles River and those Restricted Subsidiaries thereunder) then
classified as having been incurred in reliance upon this clause (1) that remains
outstanding under the New Credit Facility and the Foreign Credit Facilities
after giving effect to that incurrence does not exceed an amount equal to $215.0
million;

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     (2) the incurrence by Charles River and its Restricted Subsidiaries of
Existing Indebtedness;

     (3) the incurrence by Charles River of Indebtedness represented by the
notes and the indenture and any guarantees thereof by its Restricted
Subsidiaries pursuant to "Note Guarantees";

     (4) the incurrence by Charles River or any of its Restricted Subsidiaries
of Indebtedness represented by Capital Expenditure Indebtedness, Capital Lease
Obligations or other obligations, in each case, the proceeds of which are used
solely for the purpose of financing all or any part of the purchase price or
cost of construction or improvement of property, plant or equipment (including
acquisitions of Capital Stock of a Person that becomes a Restricted Subsidiary
to the extent of the fair market value of the property, plant or equipment so
acquired) used in the business of Charles River or that Restricted Subsidiary,
in an aggregate principal amount (or accreted value, as applicable) not to
exceed $20.0 million outstanding after giving effect to that incurrence;

     (5) Indebtedness arising from agreements of Charles River or any Restricted
Subsidiary providing for indemnification, adjustment of purchase price or
similar obligations, in each case, incurred or assumed in connection with the
disposition of any business, assets or a Subsidiary, other than guarantees of
Indebtedness incurred by any Person acquiring all or any portion of such
business, assets or Restricted Subsidiary for the purpose of financing that
acquisition; provided that:

         (a) that Indebtedness is not reflected on the balance sheet of Charles
     River or any Restricted Subsidiary (contingent obligations referred to in
     a footnote or footnotes to financial statements and not otherwise
     reflected on the balance sheet will not be deemed to be reflected on that
     balance sheet for purposes of this clause (a)); and

         (b) the maximum assumable liability in respect of that Indebtedness
     shall at no time exceed the gross proceeds including non-cash proceeds
     (the fair market value of those non-cash proceeds being measured at the
     time received and without giving effect to any subsequent changes in
     value) actually received by Charles River and/or that Restricted
     Subsidiary in connection with that disposition;

     (6) the incurrence by Charles River or any of its Restricted Subsidiaries
of Permitted Refinancing Indebtedness in exchange for, or the net proceeds of
which are used to refund, refinance or replace Indebtedness (other than
intercompany Indebtedness) that was permitted by the indenture to be incurred;

     (7) the incurrence by Charles River or any of its Restricted Subsidiaries
of intercompany Indebtedness between or among Charles River and/or any of its
Restricted Subsidiaries; provided that:

          (a) if Charles River is the obligor on that Indebtedness, that
     Indebtedness is expressly subordinated to the prior payment in full in cash
     of all Obligations with respect to the notes; and

          (b) (i) any subsequent issuance or transfer of Equity Interests that
     results in any such Indebtedness being held by a Person other than Charles
     River or a Restricted Subsidiary thereof and (ii) any sale or other
     transfer of any such Indebtedness to a Person that is not either Charles
     River or a Restricted Subsidiary thereof shall be deemed, in each case, to
     constitute an incurrence of that Indebtedness by Charles River or that
     Restricted Subsidiary, as the case may be, that was not permitted by this
     clause (7);

     (8) the incurrence by Charles River or any of its Restricted Subsidiaries
of Hedging Obligations that are incurred for the purpose of fixing or hedging;

          (a) interest rate risk with respect to any floating rate Indebtedness
     that is permitted by the terms of this indenture to be outstanding; and

          (b) exchange rate risk with respect to agreements or Indebtedness of
     that Person payable denominated in a currency other than United States
     dollars;

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provided that those agreements do not increase the Indebtedness of the obligor
outstanding at any time other than as a result of fluctuations in foreign
currency exchange rates or interest rates or by reason of fees, indemnities and
compensation payable thereunder;

     (9) the guarantee by Charles River or any of its Restricted Subsidiaries of
Indebtedness of Charles River or a Restricted Subsidiary of Charles River that
was permitted to be incurred by another provision of this covenant;

    (10) obligations in respect of performance and surety bonds and completion
guarantees (including related letters of credit) provided by Charles River or
any Restricted Subsidiary in the ordinary course of business; and

    (11) the incurrence by Charles River or any of its Restricted Subsidiaries
of additional Indebtedness in an aggregate principal amount (or accreted value,
as applicable) outstanding after giving effect to that incurrence, including all
Permitted Refinancing Indebtedness incurred to refund, refinance or replace any
Indebtedness incurred pursuant to this clause (11), not to exceed $30.0 million.

     For purposes of determining compliance with this covenant:

   o in the event that an item of Indebtedness meets the criteria of more than
     one of the categories of Permitted Indebtedness described in clauses (1)
     through (11) above or is entitled to be incurred pursuant to the first
     paragraph of this covenant, Charles River shall, in its sole discretion,
     classify that item of Indebtedness in any manner that complies with this
     covenant and that item of Indebtedness will be treated as having been
     incurred pursuant to only one of those clauses or pursuant to the first
     paragraph hereof

   o Charles River may, at any time, change the classification of an item of
     Indebtedness (or any portion thereof) to any other clause or to the first
     paragraph hereof; provided that Charles River would be permitted to incur
     that item of Indebtedness (or that portion thereof) pursuant to that other
     clause or the first paragraph hereof, as the case may be, at the time of
     reclassification

   o accrual of interest, accretion or amortization of original issue discount
     will not be deemed to be an incurrence of Indebtedness for purposes of this
     covenant.

     All Indebtedness under the New Credit Facility and the Foreign Credit
Facilities outstanding on the date on which notes are first issued and
authenticated under the indenture shall be deemed to have been incurred on that
date in reliance on the first paragraph of the covenant described under the
caption "--Certain Covenants--Incurrence of Indebtedness and Issuance of
Preferred Stock." As a result, Charles River will be permitted to incur
significant additional secured indebtedness under clause (1) of the definition
of "Permitted Indebtedness." See "Risk Factors."

     Liens

     The indenture will provide that Charles River will not, and will not permit
any of its Restricted Subsidiaries to, directly or indirectly, create, incur,
assume or suffer to exist any Lien, other than a Permitted Lien, that secures
obligations under any Pari Passu Indebtedness or subordinated Indebtedness of
Charles River on any asset or property now owned or hereafter acquired by
Charles River or any of its Restricted Subsidiaries, or any income or profits
therefrom or assign or convey any right to receive income therefrom, unless the
notes are equally and ratably secured with the obligations so secured until such
time as those obligations are no longer secured by a Lien; provided that, in any
case involving a Lien securing subordinated Indebtedness of Charles River, that
Lien is subordinated to the Lien securing the notes to the same extent that
subordinated Indebtedness is subordinated to the notes.

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     Dividend and Other Payment Restrictions Affecting Restricted Subsidiaries

     The indenture will provide that Charles River will not, and will not permit
any of its Restricted Subsidiaries to, directly or indirectly, create or
otherwise cause or suffer to exist or become effective any encumbrance or
restriction on the ability of any Restricted Subsidiary to:

     (1) (a) pay dividends or make any other distributions to Charles River or
any of its Restricted Subsidiaries (i) on its Capital Stock or (ii) with respect
to any other interest or participation in, or measured by, its profits; or

          (b) pay any Indebtedness owed to Charles River or any of its
     Restricted Subsidiaries;

     (2) make loans or advances to Charles River or any of its Restricted
Subsidiaries; or

     (3) transfer any of its properties or assets to Charles River or any of
its Restricted Subsidiaries.

     However, the foregoing restrictions will not apply to encumbrances or
restrictions existing under or by reason of:

     (1)   Existing Indebtedness as in effect on the date of the indenture;

     (2) the New Credit Facility as in effect as of the date of the indenture,
and any amendments, modifications, restatements, renewals, increases,
supplements, refundings, replacements or refinancings thereof;

     (3)   the indenture and the notes;

     (4) applicable law and any applicable rule, regulation or order;

     (5) any agreement or instrument of a Person acquired by Charles River or
any of its Restricted Subsidiaries as in effect at the time of that acquisition
(except to the extent created in contemplation of that acquisition), which
encumbrance or restriction is not applicable to any Person, or the properties or
assets of any Person, other than the Person, or the property or assets of the
Person, so acquired, provided that, in the case of Indebtedness, that
Indebtedness was permitted by the terms of the indenture to be incurred;

     (6) customary non-assignment provisions in leases entered into in the
ordinary course of business and consistent with past practices;

     (7) purchase money obligations for property acquired in the ordinary course
of business that impose restrictions of the nature described in clause (5) above
on the property so acquired;

     (8) contracts for the sale of assets, including, without limitation,
customary restrictions with respect to a Subsidiary pursuant to an agreement
that has been entered into for the sale or disposition of all or substantially
all of the Capital Stock or assets of that Subsidiary;

     (9) Permitted Refinancing Indebtedness, provided that the restrictions
contained in the agreements governing that Permitted Refinancing Indebtedness
are, in the good faith judgment of Charles River's board of directors, not
materially less favorable, taken as a whole, to the holders of the notes than
those contained in the agreements governing the Indebtedness being refinanced;

    (10) secured Indebtedness otherwise permitted to be incurred pursuant to the
covenants described under "--Incurrence of Indebtedness and Issuance of
Preferred Stock" and "--Liens" that limit the right of the debtor to dispose of
the assets securing that Indebtedness;

    (11) restrictions on cash or other deposits or net worth imposed by
customers under contracts entered into in the ordinary course of business;

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    (12) other Indebtedness or Disqualified Stock of Restricted Subsidiaries
permitted to be incurred subsequent to the Issuance Date pursuant to the
provisions of the covenant described under "--Incurrence of Indebtedness and
Issuance of Preferred Stock;"

    (13) customary provisions in joint venture agreements and other similar
agreements entered into in the ordinary course of business; and

    (14) restrictions created in connection with any Receivables Facility that,
in the good faith determination of the board of directors of Charles River, are
necessary or advisable to effect that Receivables Facility.

     Merger, Consolidation, or Sale of Assets

     The indenture will provide that Charles River may not consolidate or merge
with or into (whether or not Charles River is the surviving corporation), or
sell, assign, transfer, convey or otherwise dispose of all or substantially all
of its properties or assets in one or more related transactions to, another
Person unless:

     (1) Charles River is the surviving corporation or the Person formed by or
surviving any such consolidation or merger (if other than Charles River) or to
which that sale, assignment, transfer, conveyance or other disposition shall
have been made is a corporation organized or existing under the laws of the
United States, any state thereof or the District of Columbia;

     (2) the Person formed by or surviving any such consolidation or merger (if
other than Charles River) or the Person to which that sale, assignment,
transfer, conveyance or other disposition shall have been made assumes all the
obligations of Charles River under the registration rights agreement, the notes
and the indenture pursuant to a supplemental indenture in a form reasonably
satisfactory to the trustee;

     (3) immediately after that transaction no Default or Event of Default
exists; and

     (4) Charles River or the Person formed by or surviving any such
consolidation or merger (if other than Charles River), or to which that sale,
assignment, transfer, conveyance or other disposition shall have been made

         (a) will, at the time of such transaction and after giving pro forma
     effect thereto as if that transaction had occurred at the beginning of
     the applicable four-quarter period, be permitted to incur at least $1.00
     of additional Indebtedness pursuant to the Fixed Charge Coverage Ratio
     test set forth in the first paragraph of the covenant described under the
     caption "--Incurrence of Indebtedness and Issuance of Preferred Stock" or

         (b) would, together with its Restricted Subsidiaries, have a higher
     Fixed Charge Coverage Ratio immediately after that transaction (after
     giving pro forma effect thereto as if that transaction had occurred at
     the beginning of the applicable four-quarter period) than the Fixed
     Charge Coverage Ratio of Charles River and its Restricted Subsidiaries
     immediately prior to that transaction.

     The foregoing clause (4) will not prohibit:

         (a) a merger between Charles River and a Wholly Owned Subsidiary of
     Parent created for the purpose of holding the Capital Stock of Charles
     River;

         (b) a merger between Charles River and a Wholly Owned Restricted
     Subsidiary; or

         (c) a merger between Charles River and an Affiliate incorporated
     solely for the purpose of reincorporating Charles River in another State
     of the United State

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     so long as, in each case, the amount of Indebtedness of Charles River and
     its Restricted Subsidiaries is not increased thereby.

     The indenture will provide that Charles River will not lease all or
substantially all of its assets to any Person.

     Transactions with Affiliates

     The indenture will provide that Charles River will not, and will not permit
any of its Restricted Subsidiaries to, make any payment to, or sell, lease,
transfer or otherwise dispose of any of its properties or assets to, or purchase
any property or assets from, or enter into or make or amend any transaction,
contract, agreement, understanding, loan, advance or guarantee with, or for the
benefit of, any Affiliate of Charles River (each of the foregoing, an "Affiliate
Transaction"), unless:

     (1) that Affiliate Transaction is on terms that are no less favorable to
Charles River or that Restricted Subsidiary than those that would have been
obtained in a comparable transaction by Charles River or that Restricted
Subsidiary with an unrelated Person; and

     (2) Charles River delivers to the trustee, with respect to any Affiliate
Transaction or series of related Affiliate Transactions involving aggregate
consideration in excess of $7.5 million, either:

         (a) a resolution of the board of directors set forth in an Officers'
     Certificate certifying that the relevant Affiliate Transaction complies
     with clause (1) above and that the Affiliate Transaction has been
     approved by a majority of the disinterested members of the board of
     directors; or

         (b) an opinion as to the fairness to the holders of that Affiliate
     Transaction from a financial point of view issued by an accounting,
     appraisal or investment banking firm of national standing.

     Notwithstanding the foregoing, the following items shall not be deemed to
be Affiliate Transactions:

     (1) customary directors' fees, indemnification or similar arrangements or
any employment agreement or other compensation plan or arrangement entered into
by Charles River or any of its Restricted Subsidiaries in the ordinary course of
business (including ordinary course loans to employees not to exceed (a) $5.0
million outstanding in the aggregate at any time and (b) $2.0 million to any one
employee) and consistent with the past practice of Charles River or that
Restricted Subsidiary;

     (2) transactions between or among Charles River and/or its Restricted
Subsidiaries;

     (3) payments of customary fees by Charles River or any of its Restricted
Subsidiaries to the DLJ Merchant Banking funds and their Affiliates made for any
financial advisory, financing, underwriting or placement services or in respect
of other investment banking activities, including, without limitation, in
connection with acquisitions or divestitures which are approved by a majority of
the board of directors in good faith;

     (4) any agreement as in effect on the date of the indenture or any
amendment thereto (so long as that amendment is not disadvantageous to the
holders of the notes in any material respect) or any transaction contemplated
thereby;

     (5) payments and transactions in connection with the Transaction, including
any purchase price adjustment or any other payments made pursuant to the
Transaction Agreements or the financial advisory agreements with DLJ Securities
Corporation described under "Certain Relationships and Related Party
Transactions," and the Transaction Financing, the New Credit Facility (including
commitment, syndication and arrangement fees payable thereunder) and the
Offering (including underwriting discounts and commissions in connection
therewith) and the application of the proceeds thereof, and the payment of the
fees and expenses with respect thereto;

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     (6) Restricted Payments that are permitted by the provisions of the
indenture described under the caption "--Restricted Payments" and any Permitted
Investments; and

     (7) sales of accounts receivable, or participations therein, in connection
with any Receivables Facility.

     Sale and Leaseback Transactions

     The indenture will provide that Charles River will not, and will not permit
any of its Restricted Subsidiaries to, enter into any sale and leaseback
transaction; provided that Charles River or any Restricted Subsidiary may enter
into a sale and leaseback transaction if:

     (1) Charles River or that Restricted Subsidiary, as the case may be, could
have:

          (a) incurred Indebtedness in an amount equal to the Attributable
     Indebtedness relating to that sale and leaseback transaction pursuant to
     the Fixed Charge Coverage Ratio test set forth in the first paragraph of
     the covenant described under the caption "--Incurrence of Indebtedness and
     Issuance of Preferred Stock;" and

          (b) incurred a Lien to secure that Indebtedness pursuant to the
     covenant described under the caption "--Liens;"

     (2) the gross cash proceeds of that sale and leaseback transaction are at
least equal to the fair market value (as determined in good faith by the board
of directors and set forth in an Officers' Certificate delivered to the trustee)
of the property that is the subject of that sale and leaseback transaction; and

     (3) the transfer of assets in that sale and leaseback transaction is
permitted by, and Charles River applies the proceeds of that transaction in
compliance with, the covenant described under the caption "Repurchase at the
Option of Holders--Asset Sales."

     No Senior Subordinated Indebtedness

     The indenture will provide that

     o    Charles River will not Incur any Indebtedness that is subordinated or
          junior in right of payment to any Senior Indebtedness and senior in
          right of payment to the notes, and

     o    no Guarantor will Incur any Indebtedness that is subordinate or
          junior in right of payment to any Senior Indebtedness and senior in
          right of payment to that Guarantor's guarantee (the "Guarantee").

     Note Guarantees

     The Indenture will provide that, if any Wholly-Owned Restricted Subsidiary
of Charles River that is a Domestic Subsidiary guarantees any Indebtedness under
the New Credit Facility, then such Restricted Subsidiary shall become a
Guarantor and execute a supplemental indenture and deliver an opinion of
counsel, in accordance with the terms of the Indenture.

     Reports

     The indenture will provide that, whether or not required by the rules and
regulations of the SEC, so long as any notes are outstanding, Charles River will
furnish to the holders of notes:

     (1) all quarterly and annual financial information that would be required
to be contained in a filing with the SEC on Forms 10-Q and 10-K if Charles River
were required to file those Forms, including a "Management's Discussion and

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Analysis of Financial Condition and Results of Operations" and, with respect to
the annual information only, a report thereon by Charles River's certified
independent accountants; and

     (2) all current reports that would be required to be filed with the SEC on
Form 8-K if Charles River were required to file those reports, in each case,
within the time periods specified in the SEC's rules and regulations.

     In addition, following the consummation of the exchange offer contemplated
by the registration rights agreement, whether or not required by the rules and
regulations of the SEC, Charles River will file a copy of all that information
and reports referred to in clauses (1) and (2) above with the SEC for public
availability within the time periods specified in the SEC's rules and
regulations (unless the SEC will not accept such a filing) and make that
information available to securities analysts and prospective investors upon
request.

     In addition, Charles River has agreed that, for so long as any notes remain
outstanding, it will furnish to the holders and to securities analysts and
prospective investors, upon their request, the information required to be
delivered pursuant to Rule 144A(d)(4) under the Securities Act.

Events of Default and Remedies

     The indenture will provide that each of the following constitutes an Event
of Default:

     (1) default for 30 days in the payment when due of interest on, or
liquidated damages with respect to, the notes (whether or not prohibited by the
subordination provisions of the indenture);

     (2) default in payment when due of the principal of or premium, if any, on
the notes (whether or not prohibited by the subordination provisions of the
indenture);

     (3) failure by Charles River or any of its Restricted Subsidiaries for 30
days after receipt of notice from the trustee or holders of at least 25% in
principal amount of the notes then outstanding to comply with the provisions
described under the captions "Repurchase at the Option of Holders--Change of
Control," "--Asset Sales," "Certain Covenants--Restricted Payments,"
"--Incurrence of Indebtedness and Issuance of Preferred Stock" or "Merger,
Consolidation or Sale of Assets;"

     (4) failure by Charles River for 60 days after notice from the trustee or
the holders of at least 25% in principal amount of the notes then outstanding to
comply with any of its other agreements in the indenture or the notes;

     (5) default under any mortgage, indenture or instrument under which there
may be issued or by which there may be secured or evidenced any Indebtedness for
money borrowed by Charles River or any of its Restricted Subsidiaries (or the
payment of which is guaranteed by Charles River or any of its Restricted
Subsidiaries), whether that Indebtedness or guarantee now exists, or is created
after the date of the indenture, which default:

          (a) is caused by a failure to pay Indebtedness at its stated final
     maturity (after giving effect to any applicable grace period provided in
     that Indebtedness) (a "Payment Default"); or

          (b) results in the acceleration of that Indebtedness prior to its
     stated final maturity and, in each case, the principal amount of any such
     Indebtedness, together with the principal amount of any other such
     Indebtedness under which there has been a Payment Default or the maturity
     of which has been so accelerated, aggregates $10.0 million or more;

     (6) failure by Charles River or any of its Restricted Subsidiaries to pay
final judgments aggregating in excess of $10.0 million (net of any amounts with
respect to which a reputable and creditworthy insurance company has acknowledged
liability in writing), which judgments are not paid, discharged or stayed for a
period of 60 days;

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     (7) except as permitted by the indenture, any Guarantee shall be held in
any judicial proceeding to be unenforceable or invalid or shall cease for any
reason to be in full force and effect or any Guarantor, or any Person acting of
behalf of any Guarantor, shall deny or disaffirm its obligations under its
Guarantee; and

     (8) certain events of bankruptcy or insolvency with respect to Charles
River or any of its Restricted Subsidiaries that is a Significant Subsidiary.

     If any Event of Default (other than an Event of Default specified in clause
(8) above with respect to events of bankruptcy or insolvency with respect to
Charles River or any Restricted Subsidiary that is a Significant Subsidiary)
occurs and is continuing, the holders of at least 25% in principal amount of the
then outstanding notes may direct the trustee to declare all the notes to be due
and payable immediately. However, so long as any Indebtedness permitted to be
incurred pursuant to the New Credit Facility shall be outstanding, that
acceleration shall not be effective until the earlier of:

          (1) an acceleration of any such Indebtedness under the New Credit
     Facility; or

          (2) five business days after receipt by Charles River and the
     administrative agent under the New Credit Facility of written notice of
     that acceleration.

Except as stated in the prior sentence, upon any such declaration, the notes
shall become due and payable immediately.

     Notwithstanding the foregoing, in the case of an Event of Default specified
in clause (8) above with respect to events of bankruptcy or insolvency with
respect to Charles River or any Restricted Subsidiary that is a Significant
Subsidiary, all outstanding notes will become due and payable without further
action or notice. Holders of the notes may not enforce the indenture or the
notes except as provided in the indenture.

     The holders of a majority in aggregate principal amount of the then
outstanding notes by written notice to the trustee may on behalf of all of the
holders rescind an acceleration and its consequences if the rescission would not
conflict with any judgment or decree and if all existing Events of Default
(except nonpayment of principal, interest or premium or liquidated damages, if
any, that has become due solely because of the acceleration) have been cured or
waived, provided that, in the event of a declaration of acceleration of the
notes because an Event of Default has occurred and is continuing as a result of
the acceleration of any Indebtedness described in clause (5) above, the
declaration of acceleration of the notes shall be automatically annulled if the
holders of any Indebtedness described in that clause (5) have rescinded the
declaration of acceleration in respect of that Indebtedness within 30 days of
the date of that declaration and if:

          (1) the annulment of the acceleration of the notes would not conflict
     with any judgment or decree of a court of competent jurisdiction; and

          (2) all existing Events of Default, except non-payment of principal
     or interest on the notes that became due solely because of the
     acceleration of the notes, have been cured or waived.

     Subject to certain limitations, holders of a majority in principal amount
of the then outstanding notes may direct the trustee in its exercise of any
trust or power. The trustee may withhold from holders of the notes notice of any
continuing Default or Event of Default (except a Default or Event of Default
relating to the payment of principal or interest) if it determines that
withholding notice is in their interest.

     The holders of a majority in aggregate principal amount of the notes then
outstanding by notice to the trustee may on behalf of the holders of all of the
notes waive any existing Default or Event of Default and its consequences under
the indenture except a continuing Default or Event of Default in the payment of
interest on, or the principal of, the notes.

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     Charles River is required to deliver to the trustee annually a statement
regarding compliance with the indenture, and Charles River is required upon
becoming aware of any Default or Event of Default to deliver to the trustee a
statement specifying that Default or Event of Default.

No Personal Liability of Member, Directors, Officers, Employees and Stockholders

     No member, director, officer, employee, incorporator or stockholder of
Charles River, as such, shall have any liability for any obligations of Charles
River under the notes or the indenture or for any claim based on, in respect of,
or by reason of, those obligations or their creation. Each holder of notes by
accepting a note waives and releases all that liability. The waiver and release
are part of the consideration for issuance of the notes. That waiver may not be
effective to waive liabilities under the federal securities laws, and it is the
view of the SEC that such a waiver is against public policy.

Legal Defeasance and Covenant Defeasance

     Charles River may, at its option and at any time, elect to have all of its
obligations discharged with respect to the outstanding notes and the indenture
("Legal Defeasance") except for:

          (1) the rights of holders of outstanding notes to receive payments in
     respect of the principal of, premium, if any, and interest and liquidated
     damages, if any, on those notes when those payments are due from the trust
     referred to below;

          (2) Charles River's obligations with respect to the notes concerning
     issuing temporary notes, registration of notes, mutilated, destroyed, lost
     or stolen notes and the maintenance of an office or agency for payment and
     money for security payments held in trust;

          (3) the rights, powers, trusts, duties and immunities of the trustee,
     and Charles River's obligations in connection therewith; and

          (4) the Legal Defeasance provisions of the indenture.

     In addition, Charles River may, at its option and at any time, elect to
have its obligations released with respect to certain covenants that are
described in the indenture released ("Covenant Defeasance") and thereafter any
omission to comply with those obligations shall not constitute a Default or
Event of Default with respect to the notes. In the event Covenant Defeasance
occurs, certain events (not including non-payment with respect to the notes,
bankruptcy, receivership, rehabilitation and insolvency events) described under
"Events of Default and Remedies" will no longer constitute an Event of Default
with respect to the notes.

     In order to exercise either Legal Defeasance or Covenant Defeasance,

     (1) Charles River must irrevocably deposit with the trustee, in trust, for
the benefit of the holders of the notes, cash in United States dollars,
non-callable Government Securities, or a combination thereof, in those amounts
as will be sufficient, in the opinion of a nationally recognized firm of
independent public accountants, to pay the principal of, premium, if any, and
interest and liquidated damages, if any, on the outstanding notes on the stated
maturity or on the applicable redemption date, as the case may be, and Charles
River must specify whether the notes are being defeased to maturity or to a
particular redemption date;

     (2) in the case of Legal Defeasance, Charles River shall have delivered to
the trustee an opinion of counsel in the United States reasonably acceptable to
the trustee confirming that:

          (a) Charles River has received from, or there has been published by,
     the Internal Revenue Service a ruling; or

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          (b) since the date of the indenture, there has been a change in the
     applicable federal income tax law,

     in either case to the effect that, and based thereon that opinion of
     counsel shall confirm that, subject to customary assumptions and
     exclusions, the holders of the outstanding notes will not recognize income,
     gain or loss for federal income tax purposes as a result of that Legal
     Defeasance and will be subject to federal income tax on the same amounts,
     in the same manner and at the same times as would have been the case if
     that Legal Defeasance had not occurred;

     (3) in the case of Covenant Defeasance, Charles River shall have delivered
to the trustee an opinion of counsel in the United States reasonably acceptable
to the trustee confirming that, subject to customary assumptions and exclusions,
the holders of the outstanding notes will not recognize income, gain or loss for
federal income tax purposes as a result of that Covenant Defeasance and will be
subject to federal income tax on the same amounts, in the same manner and at the
same times as would have been the case if that Covenant Defeasance had not
occurred;

     (4) no Default or Event of Default shall have occurred and be continuing on
the date of that deposit (other than a Default or Event of Default resulting
from the borrowing of funds to be applied to that deposit) or, insofar as Events
of Default from bankruptcy or insolvency events are concerned, at any time in
the period ending on the 123rd day after the date of deposit;

     (5) that Legal Defeasance or Covenant Defeasance will not result in a
breach or violation of, or constitute a default under, any material agreement or
instrument (other than the indenture) to which Charles River or any of its
Subsidiaries is a party or by which Charles River or any of its Subsidiaries is
bound;

     (6) Charles River must have delivered to the trustee an opinion of counsel
to the effect that, subject to customary assumptions and exclusions, after the
123rd day following the deposit, the trust funds will not be subject to the
effect of Section 547 of the United States Bankruptcy Code or any analogous New
York State law provision or any other applicable federal or New York bankruptcy,
insolvency, reorganization or similar laws affecting creditors' rights
generally;

     (7) Charles River must deliver to the trustee an Officers' Certificate
stating that the deposit was not made by Charles River with the intent of
preferring the holders of notes over the other creditors of Charles River with
the intent of defeating, hindering, delaying or defrauding creditors of Charles
River or others; and

     (8) Charles River must deliver to the trustee an Officers' Certificate and
an opinion of counsel (which opinion may be subject to customary assumptions and
exclusions), each stating that all conditions precedent provided for relating to
the Legal Defeasance or the Covenant Defeasance have been complied with.

Transfer and Exchange

     A holder may transfer or exchange notes in accordance with the indenture.
The Registrar and the trustee may require a holder, among other things, to
furnish appropriate endorsements and transfer documents and Charles River may
require a holder to pay any taxes and fees required by law or permitted by the
indenture. Charles River is not required to transfer or exchange any note
selected for redemption. Also, Charles River is not required to transfer or
exchange any note for a period of 15 days before a selection of notes to be
redeemed. The registered holder of a note will be treated as the owner of it for
all purposes.

Amendment, Supplement and Waiver

     Except as provided below, the indenture and the notes may be amended or
supplemented with the consent of the holders of at least a majority in principal
amount of the notes then outstanding, and any existing default or compliance
with any provision of the indenture or the notes may be waived with the consent
of the holders of a majority in principal amount of the then outstanding notes.
Consents obtained in connection with a purchase of, or tender offer or exchange
offer for, notes shall be included for those purposes.

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     Without the consent of each holder affected, an amendment or waiver may
not, with respect to any notes held by a non-consenting holder:

          (1) reduce the principal amount of notes whose holders must consent
     to an amendment, supplement or waiver;

          (2) reduce the principal of or change the fixed maturity of any note
     or alter the provisions with respect to the redemption of the notes (other
     than the provisions described under the caption "--Repurchase at the
     Option of Holders");

          (3) reduce the rate of or extend the time for payment of interest on
     any note;

          (4) waive a Default or Event of Default in the payment of principal
     of or premium, if any, or interest or liquidated damages, if any, on the
     notes (except a rescission of acceleration of the notes by the holders of
     at least a majority in aggregate principal amount of the notes and a
     waiver of the payment default that resulted from that acceleration);

          (5) make any note payable in money other than that stated in the
     notes;

          (6) make any change in the provisions of the indenture relating to
     waivers of past Defaults;

          (7) waive a redemption payment with respect to any note (other than
     the provisions described under the caption "--Repurchase at the Option of
     Holders");

          (8) release any Guarantor from its obligations under its Guarantee or
     the indenture, except in accordance with the terms of the indenture; or

          (9) make any change in the foregoing amendment and waiver provisions.

Notwithstanding the foregoing, any

          (1) amendment to or waiver of the covenant described under the
     caption "--Repurchase at the Option of Holders--Change of Control;" and

          (2) amendment to Article 10 of the indenture (which relates to
     subordination) will require the consent of the holders of at least
     two-thirds in aggregate principal amount of the notes then outstanding if
     that amendment would materially adversely affect the rights of holders of
     notes.

Notwithstanding the foregoing, without the consent of any holder of notes,
Charles River, any Guarantor and the trustee may amend or supplement the
indenture, any Guarantee or the notes:

          (1) to cure any ambiguity, defect or inconsistency,

          (2) to provide for uncertificated notes in addition to or in place of
     certificated notes,

          (3) to provide for the assumption of Charles River's obligations to
     holders of notes in the case of a merger or consolidation or sale of all
     or substantially all of the assets of Charles River or to provide for the
     assumption of any Guarantor's obligations under its Guarantee in the case
     of a merger or consolidation of the Guarantor,

          (4) to make any change that would provide any additional rights or
     benefits to the holders of notes or that does not materially adversely
     affect the legal rights under the indenture of any such holder,

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          (5) to comply with requirements of the SEC in order to effect or
     maintain the qualification of the indenture under the Trust Indenture Act
     or

          (6) to provide for guarantees of the notes.

Concerning the Trustee

     The indenture contains certain limitations on the rights of the trustee,
should it become a creditor of Charles River, to obtain payment of claims in
certain cases, or to realize on certain property received in respect of any such
claim as security or otherwise. The trustee will be permitted to engage in other
transactions; however, if it acquires any conflicting interest it must eliminate
that conflict within 90 days, apply to the SEC for permission to continue or
resign.

     The holders of a majority in principal amount of the then outstanding notes
will have the right to direct the time, method and place of conducting any
proceeding for exercising any remedy available to the trustee, subject to
certain exceptions. The indenture provides that in case an Event of Default
shall occur (which shall not be cured), the trustee will be required, in the
exercise of its power, to use the degree of care of a prudent man in the conduct
of his own affairs. Subject to such provisions, the trustee will be under no
obligation to exercise any of its rights or powers under the indenture at the
request of any holder of notes, unless that holder shall have offered to the
trustee security and indemnity satisfactory to it against any loss, liability or
expense.

Additional Information

     Anyone who receives this prospectus may obtain a copy of the indenture and
registration rights agreement without charge by writing to Charles River at 251
Ballardvale Street, Wilmington, MA 01887, Attention: Secretary.

Book-Entry, Delivery and Form

     The certificates representing the new notes will be issued in fully
registered form, without coupons. Except as described below, the new notes will
be deposited with, or on behalf of, The Depository Trust Company, New York, New
York ("DTC"), and registered in the name of Cede & Co. as DTC's nominee, in the
form of a global note (the "global registered note").

     The Global Registered Note. Charles River expects that pursuant to
procedures established by DTC (a) upon deposit of the global registered note,
DTC or its custodian will credit on its internal system interests in the global
registered note to the accounts of persons who have accounts with DTC
("Participants") and (b) ownership of the global registered note will be shown
on, and the transfer of ownership thereof will be effected only through, records
maintained by DTC or its nominee, with respect to interests of Participants, and
the records of Participants with respect to interests of persons other than
Participants. Ownership of beneficial interests in the global registered note
will be limited to Participants or persons who hold interests through
Participants.

     So long as DTC or its nominee is the registered owner or holder of the new
notes, DTC or such nominee will be considered the sole owner or holder of the
new notes represented by the global registered note for all purposes under the
indenture. No beneficial owner of an interest in the global registered note will
be able to transfer such interest except in accordance with DTC's procedures, in
addition to those provided for under the indenture with respect to the new
notes.

     Payments of the principal of, or premium and interest on, the global
registered note will be made to DTC or its nominee, as the case may be, as the
registered owner thereof. None of Charles River, the trustee or any paying agent
under the indenture will have any responsibility or liability for any aspect of
the records relating to or payments made on account of beneficial ownership
interests in the global registered note or for maintaining, supervising or
reviewing any records relating to such beneficial ownership interest.

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     We expect that DTC or its nominee, upon receipt of any payment of the
principal of, or premium and interest on, the global registered note, will
credit Participants' accounts with payments in amounts proportionate to their
respective beneficial interests in the principal amount of such global
registered note as shown on the records of DTC or its nominee. We also expect
that payments by Participants to owners of beneficial interests in the global
registered note held through such Participants will be governed by standing
instructions and customary practice as is now the case with securities held for
the accounts of customers registered in the names of nominees for such
customers. Such payments will be the responsibility of such Participants.

     Transfers between Participants in DTC will be effected in accordance with
DTC rules and will be settled in immediately available funds. If a holder
requires physical delivery of a certificated note for any reason, including to
sell new notes to persons in states which require physical delivery of the new
notes or to pledge such securities, such holder must transfer its interest in
the global registered note in accordance with the normal procedures of DTC and
with the procedures set forth in the indenture.

     DTC has advised us that DTC will take any action permitted to be taken by a
holder of new notes, including the presentation of new notes for exchange as
described below, only at the direction of one or more Participants to whose
account at DTC interests in the global registered note are credited and only in
respect of such portion of the aggregate principal amount of new notes as to
which such Participant or Participants has or have given such direction.
However, if there is an Event of Default under the indenture, DTC will exchange
the global registered note for certificated new notes, which it will distribute
to its Participants.

     DTC has advised us as follows: DTC is a limited purpose trust company
organized under the laws of the State of New York, a member of the Federal
Reserve System, a "clearing corporation" within the meaning of the Uniform
Commercial Code and a "clearing agency" registered pursuant to the provisions of
Section 17A of the Exchange Act. DTC was created to hold securities for its
Participants and facilitate the clearance and settlement of securities
transactions between Participants through electronic book-entry changes in
accounts of its Participants, thereby eliminating the need for physical movement
of certificates. Participants include securities brokers and dealers, banks,
trust companies and clearing corporations and other organizations. Indirect
access to the DTC system is available to others such as banks, brokers, dealers
and trust companies that clear through or maintain a custodial relationship with
a Participant, either directly or indirectly ("Indirect Participants").

     Although DTC has agreed to the foregoing procedures in order to facilitate
transfers of interest in the global registered notes among Participants, it is
under no obligation to perform such procedures, and such procedures may be
discontinued at any time. Neither Charles River nor the trustee will have any
responsibility for the performance by DTC or its Participants or Indirect
Participants of their respective obligations under the rules and procedures
governing their operations.

     Certificated Notes. Interests in the global registered note will be
exchangeable or transferable, as the case may be, for certificated notes if

          (1) DTC (a) notifies us that it is unwilling or unable to continue as
     depositary for the global registered note and we fail to appoint a
     successor depositary or (b) has ceased to be a clearing agency registered
     under the Exchange Act,

          (2) We, at our option, notify the trustee in writing that we elect to
     cause the issuance of the new notes in certificated form or

          (3) there shall have occurred and be continuing to occur a Default or
     an Event of Default with respect to the new notes.

     In addition, beneficial interests in the global registered note may be
exchanged for certificated notes upon request but only upon at least 20 days'
prior written notice given to the trustee by or on behalf of DTC in accordance
with customary procedures. In all cases, certificated notes delivered in
exchange for the global registered note or beneficial

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interest therein will be registered in the names, and issued in any approved
denominations, requested by or on behalf of the depositary, in accordance with
its customary procedures.

Same Day Settlement And Payment

     The indenture will require that payments in respect of the new notes
represented by the global registered note, including principal, premium, if any,
interest and Liquidated Damages, if any, be made by wire transfer of immediately
available next day funds to the accounts specified by the holder. With respect
to certificated notes, Charles River will make all payments of principal,
premium, if any, interest and Liquidated Damages, if any, by wire transfer of
immediately available funds to the accounts specified by the holders thereof or,
if no such account is specified, by mailing a check to each such holder's
registered address. Charles River expects that secondary trading in certificated
notes will also be settled in immediately available funds.

Certain Definitions

     Set forth below are certain defined terms used in the indenture. Reference
is made to the indenture for a full disclosure of all those terms, as well as
any other capitalized terms used herein for which no definition is provided.

     "Accounts Receivable Subsidiary" means an Unrestricted Subsidiary of
Charles River to which Charles River or any of its Restricted Subsidiaries sells
any of its accounts receivable pursuant to a Receivables Facility.

     "Acquired Indebtedness" means, with respect to any specified Person,

          (1) Indebtedness of any other Person existing at the time that other
     Person is merged with or into or became a Subsidiary of that specified
     Person, including, without limitation, Indebtedness incurred in connection
     with, or in contemplation of, that other Person merging with or into or
     becoming a Subsidiary of that specified Person; and

          (2) Indebtedness secured by a Lien encumbering an asset acquired by
     that specified Person at the time that asset is acquired by that specified
     Person.

     "Affiliate" of any specified Person means any other Person which, directly
or indirectly, controls, is controlled by or is under direct or indirect common
control with, that specified Person. For purposes of this definition, "control,"
when used with respect to any Person, means the power to direct the management
and policies of that Person, directly or indirectly, whether through the
ownership of voting securities, by contract or otherwise, and the terms
"controlling" and "controlled" have meanings correlative to the foregoing.

     "Asset Sale" means:

          (1) the sale, lease, conveyance, disposition or other transfer (a
     "disposition") of any properties, assets or rights (including, without
     limitation, by way of a sale and leaseback); provided that the sale,
     lease, conveyance or other disposition of all or substantially all of the
     assets of Charles River and its Subsidiaries taken as a whole will be
     governed by the provisions of the indenture described under the caption
     "--Change of Control" and/or the provisions described under the caption
     "--Merger, Consolidation or Sale of Assets" and not by the provisions of
     the Asset Sale covenant; and

          (2) the issuance, sale or transfer by Charles River or any of its
     Restricted Subsidiaries of Equity Interests of any of Charles River's
     Restricted Subsidiaries,

     in the case of either clause (1) or (2), whether in a single transaction
     or a series of related transactions,

               (a) that have a fair market value in excess of $5.0 million; or

               (b) for net proceeds in excess of $5.0 million.

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     Notwithstanding the foregoing, the following items shall not be deemed to
be Asset Sales:

          (1) dispositions in the ordinary course of business;

          (2) a disposition of assets by Charles River to a Restricted
     Subsidiary or by a Restricted Subsidiary to Charles River or to another
     Restricted Subsidiary;

          (3) a disposition of Equity Interests by a Restricted Subsidiary to
     Charles River or to another Restricted Subsidiary;

          (4) the sale and leaseback of any assets within 90 days of the
     acquisition thereof;

          (5) foreclosures on assets;

          (6) any exchange of like property pursuant to Section 1031 of the
     Internal Revenue Code of 1986, as amended, for use in a Permitted
     Business;

          (7) any sale of Equity Interests in, or Indebtedness or other
     securities of, an Unrestricted Subsidiary;

          (8) a Permitted Investment or a Restricted Payment that is permitted
     by the covenant described under the caption "--Restricted Payments"; and

          (9) sales of accounts receivable, or participations therein, in
     connection with any Receivables Facility.

     "Attributable Indebtedness" in respect of a sale and leaseback transaction
means, at the time of determination, the present value (discounted at the rate
of interest implicit in that transaction, determined in accordance with GAAP) of
the obligation of the lessee for net rental payments during the remaining term
of the lease included in that sale and leaseback transaction, including any
period for which that lease has been extended or may, at the option of the
lessor, be extended.

     "Capital Expenditure Indebtedness" means Indebtedness incurred by any
Person to finance the purchase or construction or any property or assets
acquired or constructed by that Person which have a useful life or more than one
year so long as:

          (1) the purchase or construction price for that property or assets is
     included in "addition to property, plant or equipment" in accordance with
     GAAP;

          (2) the acquisition or construction of that property or assets is not
     part of any acquisition of a Person or line of business; and

          (3) that Indebtedness is incurred within 90 days of the acquisition
     or completion of construction of that property or assets.

     "Capital Lease Obligation" means, at the time any determination thereof is
to be made, the amount of the liability in respect of a capital lease that would
at that time be required to be capitalized on a balance sheet in accordance with
GAAP.

     "Capital Stock" means:

          (1) in the case of a corporation, corporate stock;

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          (2) in the case of an association or business entity, any and all
     shares, interests, participations, rights or other equivalents (however
     designated) of corporate stock;

          (3) in the case of a partnership or limited liability company,
     partnership or membership interests (whether general or limited); and

          (4) any other interest or participation that confers on a Person the
     right to receive a share of the profits and losses of, or distributions of
     assets of, the issuing Person.

     "Cash Equivalents" means;

          (1) Government Securities;

          (2) any certificate of deposit maturing not more than 365 days after
     the date of acquisition issued by, or demand deposit or time deposit of,
     an Eligible Institution or any lender under the New Credit Facility;

          (3) commercial paper maturing not more than 365 days after the date
     of acquisition of an issuer (other than an Affiliate of Charles River)
     with a rating, at the time as of which any investment therein is made, of
     "A-3" (or higher) according to S&P or "P-2" (or higher) according to
     Moody's or carrying an equivalent rating by a nationally recognized rating
     agency if both of the two named rating agencies cease publishing ratings
     of investments;

          (4) any bankers acceptances of money market deposit accounts issued
     by an Eligible Institution;

          (5) any fund investing exclusively in investments of the types
     described in clauses (1) through (4) above; and

          (6) in the case of any Subsidiary organized or having its principal
     place of business outside the United States, investments denominated in
     the currency of the jurisdiction in which that Subsidiary is organized or
     has its principal place of business which are similar to the items
     specified in clauses (1) through (5) above, including without limitation
     any deposit with a bank that is a lender to any Restricted Subsidiary.

     "Consolidated Cash Flow" means, with respect to any Person for any period,
the Consolidated Net Income of that Person and its Restricted Subsidiaries for
that period plus, to the extent deducted in computing Consolidated Net Income,

          (1) provision for taxes based on income or profits of that Person and
     its Restricted Subsidiaries for that period;

          (2) Fixed Charges of that Person for that period;

          (3) depreciation, amortization (including amortization of goodwill
     and other intangibles) and all other non-cash charges, but excluding any
     other non-cash charge to the extent that it represents an accrual of or
     reserve for cash expenses in any future period or amortization of a
     prepaid cash expense that was paid in a prior period, of that Person and
     its Restricted Subsidiaries for that period;

          (4) net periodic post-retirement benefits;

          (5) other income or expense net as set forth on the face of that
     Person's statement of operations;

          (6) expenses and charges of Charles River related to the
     Transactions, including any purchase price adjustment or any other
     payments made pursuant to or as contemplated in the Transaction Agreements
     or the financial advisory agreements with DLJ Securities Corporation
     described under "Certain Relationships and Related

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     Party Transactions," and Transaction Financing, the New Credit Facility
     and the application of the proceeds thereof; and

          (7) any non-capitalized transaction costs incurred in connection with
     actual, proposed or abandoned financings, acquisitions or divestitures,
     including, but not limited to, financing and refinancing fees and costs
     incurred in connection with the Transactions and Transaction Financing,

in each case, on a consolidated basis and determined in accordance with GAAP.

     Notwithstanding the foregoing, the provision for taxes based on the income
or profits of, the Fixed Charges of, and the depreciation and amortization and
other non-cash charges of, a Restricted Subsidiary of a Person shall be added to
Consolidated Net Income to compute Consolidated Cash Flow only to the extent and
in the same proportion that Net Income of that Restricted Subsidiary was
included in calculating the Consolidated Net Income of that Person.

     "Consolidated Interest Expense" means, with respect to any Person for any
period, the sum of, without duplication,

          (1) the interest expense of that Person and its Restricted
     Subsidiaries for that period, on a consolidated basis, determined in
     accordance with GAAP, including amortization of original issue discount,
     non-cash interest payments, the interest component of all payments
     associated with Capital Lease Obligations, imputed interest with respect
     to Attributable Indebtedness, commissions, discounts and other fees and
     charges incurred in respect of letter of credit or bankers' acceptance
     financings, and net payments, if any, pursuant to Hedging Obligations;
     provided that in no event shall any amortization of deferred financing
     costs be included in Consolidated Interest Expense; and

          (2) the consolidated capitalized interest of that Person and its
     Restricted Subsidiaries for that period, whether paid or accrued;
     provided, however, that Receivables Fees shall be deemed not to constitute
     Consolidated Interest Expense.

     "Consolidated Net Debt" means, with respect to any Person as of any date of
determination, the aggregate principal amount of Indebtedness for borrowed money
of such Person and its Restricted Subsidiaries as of such date, less the
aggregate amount of cash and Cash Equivalents of such Person and its Restricted
Subsidiaries, in each case determined on a consolidated basis in accordance with
GAAP.

     Notwithstanding the foregoing, the Consolidated Interest Expense with
respect to any Restricted Subsidiary that is not a Wholly Owned Restricted
Subsidiary shall be included only to the extent and in the same proportion that
the net income of that Restricted Subsidiary was included in calculating
Consolidated Net Income.

     "Consolidated Net Income" means, with respect to any Person for any period,
the aggregate of the Net Income of that Person and its Restricted Subsidiaries
for that period, on a consolidated basis, determined in accordance with GAAP;
provided that

          (1) the Net Income (or loss) of any Person that is not a Restricted
     Subsidiary or that is accounted for by the equity method of accounting
     shall be included only to the extent of the amount of dividends or
     distributions paid in cash to the referent Person or a Restricted
     Subsidiary thereof;

          (2) the Net Income (or loss) of any Restricted Subsidiary other than
     a Subsidiary organized or having its principal place of business outside
     the United States shall be excluded to the extent that the declaration or
     payment of dividends or similar distributions by that Restricted
     Subsidiary of that Net Income (or loss) is not at the date of
     determination permitted without any prior governmental approval (that has
     not been obtained) or, directly or indirectly, by operation of the terms
     of its charter or any agreement, instrument, judgment, decree, order,
     statute, rule or governmental regulation applicable to that Restricted
     Subsidiary;

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          (3) the Net Income (or loss) of any Person acquired in a pooling of
     interests transaction for any period prior to the date of that acquisition
     shall be excluded; and

          (4) the cumulative effect of a change in accounting principles shall
     be excluded.

     "Default" means any event that is or with the passage of time or the giving
of notice or both would be an Event of Default.

     "Designated Noncash Consideration" means the fair market value of non-cash
consideration received by Charles River or one of its Restricted Subsidiaries in
connection with an Asset Sale that is so designated as Designated Noncash
Consideration pursuant to an Officers' Certificate, setting forth the basis of
that valuation, executed by the principal executive officer and the principal
financial officer of Charles River, less the amount of cash or Cash Equivalents
received in connection with a sale of that Designated Noncash Consideration.

     "Disqualified Stock" means any Capital Stock that, by its terms (or by the
terms of any security into which it is convertible, or for which it is
exchangeable), or upon the happening of any event (other than any event solely
within the control of the issuer thereof), matures or is mandatorily redeemable,
pursuant to a sinking fund obligation or otherwise, is exchangeable for
Indebtedness (except to the extent exchangeable at the option of that Person
subject to the terms of any debt instrument to which that Person is a party) or
redeemable at the option of the holder thereof, in whole or in part, on or prior
to the date on which the notes mature; provided that any Capital Stock that
would constitute Disqualified Stock solely because the holders thereof have the
right to require Charles River to repurchase that Capital Stock upon the
occurrence of a Change of Control or an Asset Sale shall not constitute
Disqualified Stock if the terms of that Capital Stock provide that Charles River
may not repurchase or redeem any such Capital Stock pursuant to those provisions
unless that repurchase or redemption complies with the covenant described under
the caption "--Certain Covenants--Restricted Payments," and provided further
that, if that Capital Stock is issued to any plan for the benefit of employees
of Charles River or its Subsidiaries or by any such plan to those employees,
that Capital Stock shall not constitute Disqualified Stock solely because it may
be required to be repurchased by Charles River in order to satisfy applicable
statutory or regulatory obligations.

     "DLJ Merchant Banking Funds" means DLJ Merchant Banking Partners II, L.P.
and its Affiliates.

     "Domestic Subsidiary" means a Subsidiary that is organized under the laws
of the United States or any State, district or territory thereof.

     "Eligible Institution" means a commercial banking institution that has
combined capital and surplus not less than $100.0 million or its equivalent in
foreign currency, whose short-term debt is rated "A-3" or higher according to
Standard & Poor's Ratings Group ("S&P") or "P-2" or higher according to Moody's
Investor Services, Inc. ("Moody's") or carrying an equivalent rating by a
nationally recognized rating agency if both of the two named rating agencies
cease publishing ratings of investments.

     "Equity Interests" means Capital Stock and all warrants, options or other
rights to acquire Capital Stock (but excluding any debt security that is
convertible into, or exchangeable for, Capital Stock).

     "Existing Indebtedness" means Indebtedness of Charles River and its
Restricted Subsidiaries (other than Indebtedness under the New Credit Facility)
in existence on the date of the indenture, until those amounts are repaid.

     "Fixed Charges" means, with respect to any Person for any period, the sum,
without duplication, of,

          (1) the Consolidated Interest Expense of that Person for that period;
     and

          (2) all dividend payments on any series of preferred stock of that
     Person (other than dividends payable solely in Equity Interests that are
     not Disqualified Stock),

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<PAGE>



in each case, on a consolidated basis and in accordance with GAAP.

     "Fixed Charge Coverage Ratio" means, with respect to any Person for any
period, the ratio of the Consolidated Cash Flow of that Person for that period
(exclusive of amounts attributable to discontinued operations, as determined in
accordance with GAAP, or operations and businesses disposed of prior to the
Calculation Date (as defined)) to the Fixed Charges of that Person for that
period (exclusive of amounts attributable to discontinued operations, as
determined in accordance with GAAP, or operations and businesses disposed of
prior to the Calculation Date).

     In the event that the referent Person or any of its Subsidiaries incurs,
assumes, guarantees or redeems any Indebtedness (other than revolving credit
borrowings) or issues or redeems preferred stock subsequent to the commencement
of the period for which the Fixed Charge Coverage Ratio is being calculated but
prior to the date on which the event for which the calculation of the Fixed
Charge Coverage Ratio is made (the "Calculation Date"), then the Fixed Charge
Coverage Ratio shall be calculated giving pro forma effect to that incurrence,
assumption, guarantee or redemption of Indebtedness, or that issuance or
redemption of preferred stock and the use of the proceeds therefrom, as if the
same had occurred at the beginning of the applicable four-quarter reference
period.

     In addition, for purposes of making the computation referred to above, the
Recapitalization and acquisitions that have been made by Charles River or any of
its Subsidiaries, including all mergers or consolidations and any related
financing transactions, during the four-quarter reference period or subsequent
to that reference period and on or prior to the Calculation Date shall be deemed
to have occurred on the first day of the four-quarter reference period and
Consolidated Cash Flow for that reference period shall be calculated to include
the Consolidated Cash Flow of the acquired entities on a pro forma basis after
giving effect to cost savings reasonably expected to be realized in connection
with that acquisition, as determined in good faith by an officer of Charles
River (regardless of whether those cost savings could then be reflected in pro
forma financial statements under GAAP, Regulation S-X promulgated by the SEC or
any other regulation or policy of the SEC) and without giving effect to clause
(3) of the proviso set forth in the definition of Consolidated Net Income.

     "Foreign Credit Facilities" means any Indebtedness of a Restricted
Subsidiary organized or having its principal place of business outside the
United States. Indebtedness under the Foreign Credit Facilities outstanding on
the date on which the notes are first issued and authenticated under the
indenture shall be deemed to have been incurred on that date in reliance on the
first paragraph of the covenant described under the caption "--Certain
Covenants--Incurrence of Indebtedness and Issuance of Preferred Stock."

     "GAAP" means generally accepted accounting principles set forth in the
opinions and pronouncements of the Accounting Principles Board of the American
Institute of Certified Public Accountants and statements and pronouncements of
the Financial Accounting Standards Board or in such other statements by such
other entity as have been approved by a significant segment of the accounting
profession, which are in effect on the date of the indenture.

     "guarantee" means a guarantee (other than by endorsement of negotiable
instruments for collection in the ordinary course of business), direct or
indirect, in any manner (including, without limitation, letters of credit or
reimbursement agreements in respect thereof), of all or any part of any
Indebtedness.

     "Guarantor" means any Subsidiary that executes a Note Guarantee in
accordance with the provisions of the indenture.

     "Hedging Obligations" means, with respect to any Person, the obligations of
that Person under (a) interest rate swap agreements, interest rate cap
agreements and interest rate collar agreements and (b) other agreements or
arrangements designed to protect that Person against fluctuations in interest
rates.


     "Holdings" means Charles River Laboratories, Inc.


     "Indebtedness" means, with respect to any Person, any indebtedness of that
Person in respect of borrowed money or evidenced by bonds, notes, debentures or
similar instruments or letters of credit (or reimbursement agreements in respect
thereof) or banker's acceptances or representing Capital Lease Obligations or
the balance deferred and unpaid of the purchase price of any property or
representing any Hedging Obligations, except any such balance that constitutes
an


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accrued expense, trade payable or customer contract advances, if and to the
extent any of the foregoing Indebtedness (other than letters of credit and
Hedging Obligations) would appear as a liability upon a balance sheet of that
Person prepared in accordance with GAAP, as well as all Indebtedness of others
secured by a Lien on any asset of that Person (whether or not that Indebtedness
is assumed by that Person) and, to the extent not otherwise included, the
guarantee by that Person of any Indebtedness of any other Person, provided that
Indebtedness shall not include the pledge by Charles River of the Capital Stock
of an Unrestricted Subsidiary of Charles River to secure Non-Recourse Debt of
that Unrestricted Subsidiary.

     The amount of any Indebtedness outstanding as of any date shall be:

          (1) the accreted value thereof, in the case of any Indebtedness that
     does not require current payments of interest; and

          (2) the principal amount thereof (together with any interest thereon
     that is more than 30 days past due), in the case of any other Indebtedness
     provided that the principal amount of any Indebtedness that is denominated
     in any currency other than United States dollars shall be the amount
     thereof, as determined pursuant to the foregoing provision, converted into
     United States dollars at the Spot Rate in effect on the date that
     Indebtedness was incurred or, if that indebtedness was incurred prior to
     the date of the indenture, the Spot Rate in effect on the date of the
     indenture.

     "Investments" means, with respect to any Person, all investments by that
Person in other Persons, including Affiliates, in the forms of direct or
indirect loans (including guarantees by the referent Person of, and Liens on any
assets of the referent Person securing, Indebtedness or other obligations of
other Persons), advances or capital contributions (excluding commission, travel
and similar advances to officers and employees made in the ordinary course of
business), purchases or other acquisitions for consideration of Indebtedness,
Equity Interests or other securities, together with all items that are or would
be classified as investments on a balance sheet prepared in accordance with
GAAP, provided that an investment by Charles River for consideration consisting
of common equity securities of Charles River shall not be deemed to be an
Investment other than for purposes of clause (3) of the definition of "Qualified
Proceeds."

     If Charles River or any Restricted Subsidiary of Charles River sells or
otherwise disposes of any Equity Interests of any direct or indirect Restricted
Subsidiary of Charles River such that, after giving effect to any such sale or
disposition, that Person is no longer a Subsidiary of Charles River, Charles
River shall be deemed to have made an Investment on the date of any such sale or
disposition equal to the fair market value of the Equity Interests of that
Restricted Subsidiary not sold or disposed of in an amount determined as
provided in the final paragraph of the covenant described under the caption
"--Restricted Payments."

     "Lien" means, with respect to any asset, any mortgage, lien, pledge,
charge, security interest or encumbrance of any kind in respect of that asset,
whether or not filed, recorded or otherwise perfected under applicable law,
including any conditional sale or other title retention agreement, any lease in
the nature thereof, any option or other agreement to sell or give a security
interest in and any filing of or agreement to give any financing statement under
the Uniform Commercial Code (or equivalent statutes) of any jurisdiction.

     "Management Loans" means one or more loans by Charles River or Parent to
officers and/or directors of Charles River and any of its Restricted
Subsidiaries to finance the purchase by such officers and directors of common
stock of Parent or Charles River or membership interests in CRL Acquisition LLC;
provided that the aggregate principal amount of all such Management Loans
outstanding at any time shall not exceed $1.5 million.

     "Net Income" means, with respect to any Person, the net income (loss) of
that Person, determined in accordance with GAAP and before any reduction in
respect of preferred stock dividends, excluding, however:

          (1) any gain (or loss), together with any related provision for taxes
     on that gain (or loss), realized in connection with:

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               (a) any Asset Sale, including, without limitation, dispositions
          pursuant to sale and leaseback transactions; or

               (b) the extinguishment of any Indebtedness of that Person or any
          of its Restricted Subsidiaries; and

          (2) any extraordinary or nonrecurring gain (or loss), together with
     any related provision for taxes on that extraordinary or nonrecurring gain
     (or loss).

     "Net Proceeds" means the aggregate cash proceeds received by Charles River
or any of its Restricted Subsidiaries in respect of any Asset Sale (including,
without limitation, any cash received upon the sale or other disposition of any
non-cash consideration received in any Asset Sale), net of, without duplication,

          (1) the direct costs relating to that Asset Sale, including, without
     limitation, legal, accounting and investment banking fees, and sales
     commissions, recording fees, title transfer fees and appraiser fees and
     cost of preparation of assets for sale, and any relocation expenses
     incurred as a result thereof;

          (2) taxes paid or payable as a result thereof (after taking into
     account any available tax credits or deductions and any tax sharing
     arrangements);

          (3) amounts required to be applied to the repayment of Indebtedness
     (other than revolving credit Indebtedness incurred pursuant to the New
     Credit Facility) secured by a Lien on the asset or assets that were the
     subject of that Asset Sale; and

          (4) any reserve established in accordance with GAAP or any amount
     placed in escrow, in either case for adjustment in respect of the sale
     price of such asset or assets until such time as that reserve is reversed
     or that escrow arrangement is terminated, in which case Net Proceeds shall
     include only the amount of the reserve so reversed or the amount returned
     to Charles River or its Restricted Subsidiaries from that escrow
     arrangement, as the case may be.

     "New Credit Facility" means that certain Credit Agreement, dated as of
September 29, 1999 among Charles River, certain subsidiaries of Charles River
from time to time party thereto as guarantors, various financial institutions
party thereto, and DLJ Capital Funding, Inc., as syndication agent and
administrative agent, including any related notes, guarantees, letters of credit
collateral documents, rate protection or hedging arrangement, instruments and
agreements executed in connection therewith, and, in each case, as amended,
modified, renewed, refunded, replaced or refinanced from time to time, including
any agreement:

          (1) extending or shortening the maturity of any Indebtedness incurred
     thereunder or contemplated thereby;

          (2) adding or deleting borrowers or guarantors thereunder;

          (3) increasing the amount of Indebtedness incurred thereunder or
     available to be borrowed thereunder, provided that on the date that
     Indebtedness is incurred it would not be prohibited by clause (1) of the
     second paragraph of the covenant described under the caption "--Incurrence
     of Indebtedness and Issuance of Preferred Stock"; or

          (4) otherwise altering the terms and conditions thereof.

     Indebtedness under the New Credit Facility outstanding on the date on which
notes are first issued and authenticated under the indenture shall be deemed to
have been incurred on that date in reliance on the first paragraph of the
covenant described under the caption "--Certain Covenants--Incurrence of
Indebtedness and Issuance of Preferred Stock."

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     "Non-Recourse Debt" means Indebtedness,

          (1) no default with respect to, which (including any rights that the
     holders thereof may have to take enforcement action against an
     Unrestricted Subsidiary) would permit (upon notice, lapse of time or both)
     any holder of any other Indebtedness of Charles River or any of its
     Restricted Subsidiaries to declare a default on such other Indebtedness or
     cause the payment thereof to be accelerated or payable prior to its stated
     maturity; and

          (2) as to which the lenders have been notified in writing that they
     will not have any recourse to the stock (other than the stock of an
     Unrestricted Subsidiary pledged by Charles River to secure debt of that
     Unrestricted Subsidiary) or assets of Charles River or any of its
     Restricted Subsidiaries;

provided that in no event shall Indebtedness of any Unrestricted Subsidiary fail
to be Non-Recourse Debt solely as a result of any default provisions contained
in a guarantee thereof by Charles River or any of its Restricted Subsidiaries if
Charles River or that Restricted Subsidiary was otherwise permitted to incur
that guarantee pursuant to the indenture.

     "Obligations" means any principal, interest, penalties, fees,
indemnifications, reimbursements, damages and other liabilities payable under
the documentation governing any Indebtedness.

     "Offering" means the offering of the units by Charles River.

     "Parent" means Charles River Laboratories Holdings Inc., the corporate
parent of Charles River, or its successors.

     "Pari Passu Indebtedness" means Indebtedness of Charles River that ranks
pari passu in right of payment to the notes.

     "Permitted Business" means any person engaged, directly or indirectly, in
the animal research or biomedical products and services business or any business
reasonably related, incidental or ancillary thereto.

     "Permitted Investments" means:

          (1) any Investment in Charles River or in a Restricted Subsidiary of
     Charles River;

          (2) any Investment in cash or Cash Equivalents;

          (3) any Investment by Charles River or any Restricted Subsidiary of
     Charles River in a Person, if as a result of that Investment,

               (a) that Person becomes a Restricted Subsidiary of Charles
          River; or

               (b) that Person is merged, consolidated or amalgamated with or
          into, or transfers or conveys substantially all of its assets to, or
          is liquidated into, Charles River or a Wholly Owned Restricted
          Subsidiary of Charles River;

          (4) any Investment made as a result of the receipt of non-cash
     consideration from an Asset Sale that was made pursuant to and in
     compliance with the covenant described under the caption "--Repurchase at
     the Option of Holders--Asset Sales";

          (5) any Investment acquired solely in exchange for Equity Interests
     (other than Disqualified Stock) of Charles River;

          (6) any Investment in a Person engaged in a Permitted Business (other
     than an Investment in an Unrestricted Subsidiary) having an aggregate fair
     market value, taken together with all other Investments made pursuant to
     this clause (6) that are at that time outstanding, not to exceed 15% of
     Total Assets at the time of that


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     Investment (with the fair market value of each Investment being measured
     at the time made and without giving effect to subsequent changes in
     value);

          (7) Investments relating to any special purpose Wholly Owned
     Subsidiary of Charles River organized in connection with a Receivables
     Facility that, in the good faith determination of the board of directors
     of Charles River, are necessary or advisable to effect that Receivables
     Facility;

          (8) the Management Loans or Investments in Parent to fund Management
     Loans; and

          (9) Hedging Obligations permitted to be incurred under "--Certain
     Covenants--Incurrence of Indebtedness and Issuance of Preferred Stock."

     "Permitted Liens" means:

          (1) Liens on property of a Person existing at the time that Person is
     merged into or consolidated with Charles River or any Restricted
     Subsidiary, provided that those Liens were not incurred in contemplation
     of that merger or consolidation and do not secure any property or assets
     of Charles River or any Restricted Subsidiary other than the property or
     assets subject to the Liens prior to that merger or consolidation;

          (2) Liens existing on the date of the indenture;

          (3) Liens securing Indebtedness consisting of Capitalized Lease
     Obligations, purchase money Indebtedness, mortgage financings, industrial
     revenue bonds or other monetary obligations, in each case incurred solely
     for the purpose of financing all or any part of the purchase price or cost
     of construction or installation of assets used in the business of Charles
     River or its Restricted Subsidiaries, or repairs, additions or
     improvements to those assets, provided that:

               (a) those Liens secure Indebtedness in an amount not in excess
          of the original purchase price or the original cost of any such
          assets or repair, additional or improvement thereto (plus an amount
          equal to the reasonable fees and expenses in connection with the
          incurrence of that Indebtedness);

               (b) those Liens do not extend to any other assets of Charles
          River or its Restricted Subsidiaries (and, in the case of repair,
          addition or improvements to any such assets, that Lien extends only
          to the assets (and improvements thereto or thereon) repaired, added
          to or improved);

               (c) the Incurrence of that Indebtedness is permitted by
          "--Certain Covenants--Incurrence of Indebtedness and Issuance of
          Preferred Stock;" and

               (d) those Liens attach within 365 days of that purchase,
          construction, installation, repair, addition or improvement;

          (4) Liens to secure any refinancings, renewals, extensions,
     modification or replacements (collectively, "refinancing") (or successive
     refinancings), in whole or in part, of any Indebtedness secured by Liens
     referred to in the clauses above so long as that Lien does not extend to
     any other property (other than improvements thereto);

          (5) Liens securing letters of credit entered into in the ordinary
     course of business and consistent with past business practice;

          (6) Liens on and pledges of the capital stock of any Unrestricted
     Subsidiary securing Non-Recourse Debt of that Unrestricted Subsidiary;

          (7) Liens securing (a) Indebtedness (including all Obligations) under
     the New Credit Facility or any Foreign Credit Facility (b) Hedging
     Obligations payable to a lender under the New Credit Facility or an
     Affiliate

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     thereof or to a Person that was a lender of Affiliate thereof at the time
     the contract was entered into to the extent such Hedging Obligations are
     secured by Liens on assets also securing Indebtedness (including all
     Obligations) under the New Credit Facility; and

          (8) other Liens securing Indebtedness that is permitted by the terms
     of the indenture to be outstanding having an aggregate principal amount at
     any one time outstanding not to exceed $50.0 million.

     "Permitted Refinancing Indebtedness" means any Indebtedness of Charles
River or any of its Restricted Subsidiaries issued within 60 days after
repayment of, in exchange for, or the net proceeds of which are used to extend,
refinance, renew, replace, defease or refund other Indebtedness of Charles River
or any of its Restricted Subsidiaries; provided that:

          (1) the principal amount (or accreted value, if applicable) of that
     Permitted Refinancing Indebtedness does not exceed the principal amount of
     (or accreted value, if applicable), plus premium, if any, and accrued
     interest on the Indebtedness so extended, refinanced, renewed, replaced,
     defeased or refunded (plus the amount of reasonable expenses incurred in
     connection therewith);

          (2) that Permitted Refinancing Indebtedness has a final maturity date
     no earlier than the final maturity date of, and has a Weighted Average
     Life to Maturity equal to or greater than the Weighted Average Life to
     Maturity of, the Indebtedness being extended, refinanced, renewed,
     replaced, defeased or refunded; and

          (3) if the Indebtedness being extended, refinanced, renewed,
     replaced, defeased or refunded is subordinated in right of payment to the
     notes, that Permitted Refinancing Indebtedness is subordinated in right of
     payment to, the notes on terms at least as favorable, taken as a whole, to
     the holders of notes as those contained in the documentation governing the
     Indebtedness being extended, refinanced, renewed, replaced, defeased or
     refunded.

     "Principals" means the DLJ Merchant Banking Funds.

     "Public Equity Offering" means

     o    any issuance of common stock by Charles River, other than to Parent
          and other than Disqualified Stock

     o    any issuance of common stock or preferred stock by Parent, other than
          Disqualified Stock

that is registered pursuant to the Securities Act, other than issuances
registered on Form S-8 and issuances registered on Form S-4, excluding issuances
of common stock pursuant to employee benefit plans of Parent or Charles River or
otherwise as compensation to employees of Parent or Charles River.

     "Qualified Proceeds" means any of the following or any combination of the
following:

          (1) cash;

          (2) Cash Equivalents;

          (3) assets (other than Investments) that are used or useful in a
     Permitted Business; and

          (4) the Capital Stock of any Person engaged in a Permitted Business
     if, in connection with the receipt by Charles River or any Restricted
     Subsidiary of Charles River of that Capital Stock,

               (a) that Person becomes a Restricted Subsidiary of Charles River
          or any Restricted Subsidiary of Charles River; or

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               (b) that Person is merged, consolidated or amalgamated with or
          into, or transfers or conveys substantially all of its assets to, or
          is liquidated into, Charles River or any Restricted Subsidiary of
          Charles River.

     "Ratio of Consolidated Net Debt to Consolidated Cash Flow" means, with
respect to any Person as of any date of determination, the ratio of (x) the
Consolidated Net Debt of such Person as of such date of determination (exclusive
of amounts attributable to discontinued operations, as determined in accordance
with GAAP, or operations and businesses disposed of prior to the date of
determination) to the (y) the Consolidated Cash Flow of such Person for the four
full fiscal quarters ending on or immediately preceding such date of
determination (exclusive of amounts attributable to discontinued operations, as
determined in accordance with GAAP, or operations and businesses disposed of
prior to the date of determination).

     In the event that the referent Person or any of its Subsidiaries incurs,
assumes, guarantees or redeems any Indebtedness (other than revolving credit
borrowings) or issues or redeems preferred stock subsequent to the commencement
of the period for which the Ratio of Consolidated Net Debt to Consolidated Cash
Flow is being calculated but prior to the date of determination, then the Ratio
of Consolidated Net Debt to Consolidated Cash Flow shall be calculated giving
pro forma effect to that incurrence, assumption, guarantee or redemption of
Indebtedness, or that issuance or redemption of preferred stock and the use of
the proceeds therefrom, as if the same had occurred at the beginning of the
applicable four-quarter reference period.

     In addition, for purposes of making the computation referred to above, the
Recapitalization and acquisitions that have been made by Charles River or any of
its Subsidiaries, including all mergers or consolidations and any related
financing transactions, during the four-quarter reference period shall be deemed
to have occurred on the first day of the four-quarter reference period and
Consolidated Cash Flow for that reference period shall be calculated to include
the Consolidated Cash Flow of the acquired entities on a pro forma basis after
giving effect to cost savings reasonably expected to be realized in connection
with that acquisition, as determined in good faith by an officer of Charles
River (regardless of whether those cost savings could then be reflected in pro
forma financial statements under GAAP, Regulation S-X promulgated by the SEC or
any other regulation or policy of the SEC) and without giving effect to clause
(3) of the proviso set forth in the definition of Consolidated Net Income.

     "Recapitalization" means the recapitalization of Charles River by the
Principals and their Related Parties pursuant to the terms of the
Recapitalization Agreement.

     "Recapitalization Agreement" means that certain Recapitalization Agreement
dated as of July 25, 1999 among Charles River, B&L, Parent, Charles River
Laboratories, Inc., Charles River SPAFAS, Inc., Bausch & Lomb International,
Inc., Wilmington Partners, L.P., Bausch & Lomb Canada, Inc., CRL Acquisition LLC
and DLJ Merchant Banking Partners II, L.P.

     "Receivables Facility" means one or more receivables financing facilities,
as amended from time to time, pursuant to which Charles River or any of its
Restricted Subsidiaries sells its accounts receivable to an Accounts Receivable
Subsidiary.

     "Receivables Fees" means distributions or payments made directly or by
means of discounts with respect to any participation interests issued or sold in
connection with, and other fees paid to a Person that is not a Restricted
Subsidiary in connection with, any Receivables Facility.

     "Related Party" means, with respect to any Principal,

          (1) any controlling stockholder or partner of that Principal on the
     date of the indenture; or

          (2) any trust, corporation, partnership or other entity, the
     beneficiaries, stockholders, partners, owners or Persons beneficially
     holding (directly or through one or more Subsidiaries) a 51% or more
     controlling interest of

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     which consist of the Principals and/or such other Persons referred to in
     the immediately preceding clauses (1) or (2).

     "Restricted Investment" means an Investment other than a Permitted
Investment.

     "Restricted Subsidiary" of a Person means any Subsidiary of the referent
Person that is not an Unrestricted Subsidiary.

     "Sierra Acquisition" means the acquisition of SBI Holdings, Inc. by
Charles River pursuant to the terms of the Sierra Acquisition Agreement.

     "Sierra Acquisition Agreement" means Stock Purchase Agreement among
Charles River Laboratories, Inc. and SBI Holdings, Inc. and its stockholders
dated September 3, 1999.

     "Significant Subsidiary" means any Subsidiary that would be a "significant
subsidiary" as defined in Article 1, Rule 1-02 of Regulation S-X, promulgated
pursuant to the Securities Act, as that Regulation is in effect on the date
hereof.

     "Spot Rate" means, for any currency, the spot rate at which that currency
is offered for sale against United States dollars as determined by reference to
the New York foreign exchange selling rates, as published in The Wall Street
Journal on that date of determination for the immediately preceding business
day or, if that rate is not available, as determined in any publicly available
source of similar market data.

     "Stated Maturity" means, with respect to any installment of interest or
principal on any series of Indebtedness, the date on which that payment of
interest or principal was scheduled to be paid in the original documentation
governing that Indebtedness, and shall not include any contingent obligations to
repay, redeem or repurchase any that interest or principal prior to the date
originally scheduled for the payment thereof.

     "Subsidiary" means, with respect to any Person,

          (1) any corporation, association or other business entity of which
     more than 50% of the total voting power of shares of Capital Stock
     entitled (without regard to the occurrence of any contingency) to vote in
     the election of directors, managers or trustees thereof is at the time
     owned or controlled, directly or indirectly, by that Person or one or more
     of the other Subsidiaries of that Person (or a combination thereof); and

          (2) any partnership or limited liability company,

               (a) the sole general partner or the managing general partner or
          managing member of which is that Person or a Subsidiary of that
          Person; or

               (b) the only general partners or managing members of which are
          that Person or of one or more Subsidiaries of that Person (or any
          combination thereof).

     "Tax Sharing Agreement" means any tax sharing agreement or arrangement
between Charles River and Parent, as the same may be amended from time to time;
provided that in no event shall the amount permitted to be paid pursuant to all
such agreements and/or arrangements exceed the amount Charles River would be
required to pay for income taxes were it to file a consolidated tax return for
itself and its consolidated Restricted Subsidiaries as if it were a corporation
that was a parent of a consolidated group.

     "Total Assets" means the total consolidated assets of Charles River and its
Restricted Subsidiaries, as shown on the most recent balance sheet (excluding
the footnotes thereto) of Charles River.

     "Transactions" means the Recapitalization and the Sierra Acquisition.

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     "Transaction Agreements" means the Recapitalization Agreement and the
Sierra Acquisition Agreement.

     "Transaction Financing" means;

          (1) the issuance and sale by Parent of senior discount debentures
     with warrants and senior subordinated discount note for consideration

          (2) the issuance and sale by Charles River of the notes; and

          (3) the execution and delivery by Charles River and certain of its
     subsidiaries of the New Credit Facility and the borrowing of loans, if
     any, and issuance of letters of credit thereunder to fund the Transactions
     and any related transactions, including without limitation, the payment of
     fees and expenses and the refinancing of outstanding indebtedness of
     Charles River and its subsidiaries;

the proceeds of each of which were used to fund the purchase price for the
Recapitalization and related fees and expenses.

     "Unrestricted Subsidiary" means any Subsidiary that is designated by the
board of directors as an Unrestricted Subsidiary pursuant to a board resolution,
but only to the extent that Subsidiary:

          (1) has no Indebtedness other than Non-Recourse Debt;

          (2) is not party to any agreement, contract, arrangement or
     understanding with Charles River or any Restricted Subsidiary of Charles
     River unless the terms of any such agreement, contract, arrangement or
     understanding are no less favorable to Charles River or that Restricted
     Subsidiary than those that might be obtained at the time from Persons who
     are not Affiliates of Charles River;

          (3) is a Person with respect to which neither Charles River nor any
     of its Restricted Subsidiaries has any direct or indirect obligation,

               (a) to subscribe for additional Equity Interests (other than
          Investments described in clause (7) of the definition of Permitted
          Investments); or

               (b) to maintain or preserve that Person's financial condition or
          to cause that Person to achieve any specified levels, of operating
          results; and

          (4) has not guaranteed or otherwise directly or indirectly provided
     credit support for any Indebtedness of Charles River or any of its
     Restricted Subsidiaries.

     Any such designation by the board of directors shall be evidenced to the
trustee by filing with the trustee a certified copy of the board resolution
giving effect to that designation and an Officers' Certificate certifying that
designation complied with the foregoing conditions and was permitted by the
covenant described under the caption entitled "--Certain Covenants--Restricted
Payments." If, at any time, any Unrestricted Subsidiary would fail to meet the
foregoing requirements as a Unrestricted Subsidiary, it shall thereafter cease
to be an Unrestricted Subsidiary for purposes of the indenture and any
Indebtedness of that Subsidiary shall be deemed to be incurred by a Restricted
Subsidiary of Charles River as of that date (and, if that Indebtedness is not
permitted to be incurred as of that date under the covenant described under the
caption entitled "--Certain Covenants--Incurrence of Indebtedness and Issuance
of Preferred Stock," Charles River shall be in default of that covenant).

     The board of directors of Charles River may at any time designate any
Unrestricted Subsidiary to be a Restricted Subsidiary; provided that the
designation shall be deemed to be an incurrence of Indebtedness by a Restricted
Subsidiary of Charles River of any outstanding Indebtedness of that Unrestricted
Subsidiary and that designation shall only be permitted if:

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          (1) that Indebtedness is permitted under the covenant described under
     the caption entitled "--Certain Covenants--Incurrence of Indebtedness and
     Issuance of Preferred Stock"; and

          (2) no Default or Event of Default would be in existence following
     that designation.

     "Weighted Average Life to Maturity" means, when applied to any Indebtedness
at any date, the number of years obtained by dividing:

          (1) the sum of the products obtained by multiplying,

               (a) the amount of each then remaining installment, sinking fund,
          serial maturity or other required payments of principal, including
          payment at final maturity, in respect thereof; by

               (b) the number of years (calculated to the nearest one-twelfth)
          that will elapse between that date and the making of that payment; by

          (2) the then outstanding principal amount of that Indebtedness.

     "Wholly Owned Restricted Subsidiary" of any Person means a Restricted
Subsidiary of that Person all the outstanding Capital Stock or other ownership
interests of which (other than directors' qualifying shares) shall at the time
be owned by that Person or by one or more Wholly Owned Restricted Subsidiaries
of that Person or by that Person and one or more Wholly Owned Restricted
Subsidiaries of that Person.

     "Wholly Owned Subsidiary" of any Person means a Subsidiary of that Person
all of the outstanding Capital Stock or other ownership interests of which
(other than directors' qualifying shares) shall at the time be owned by that
Person or by one or more Wholly Owned Subsidiaries of that Person.

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<PAGE>



                               THE EXCHANGE OFFER

     Pursuant to a registration rights agreement between Charles River and the
initial purchaser, we agreed

          (1) to file a registration statement on or prior to 90 days after the
     closing of the offering of the old notes with respect to an offer to
     exchange the old notes for new debt securities of Charles River registered
     under the Securities Act, with terms identical in all material respects to
     those of the old notes and

          (2) to use our reasonable best efforts to cause the registration
     statement to be declared effective by the SEC on or prior to 180 days
     after the closing of the old notes, September 29, 1999. In some
     circumstances, we will be required to provide a shelf registration
     statement to cover resales of the old notes by the holders thereof.

     The registration rights agreement provides that, in the event we fail to
satisfy our registration obligations under the registration rights agreement, we
will be required to pay liquidated damages in an amount equal to $0.05 per week
per $1,000 principal amount and increasing every 90 days thereafter up to a
maximum amount equal to $0.25 per week per $1,000 principal amount of notes
until the registration statement is declared effective. Upon consummation of the
exchange offer or the effectiveness of a registration statement, the provision
for liquidated damages on the old notes shall cease.

     The new notes have been registered under the Securities Act and transfer
restrictions and registration rights relating to the old notes do not apply to
the new notes. If you fail to exchange your old notes in the exchange offer,
your notes will remain subject to transfer restrictions.

     The exchange offer is not being made to, nor will we accept tenders for
exchange from, holders of old notes in any jurisdiction in which the exchange
offer or the acceptance thereof would not be in compliance with the securities
or blue sky laws of such jurisdiction. Each holder of old notes that wishes to
exchange old notes for new notes is required to make the representations
described below under "--Resale of the New Notes."

Terms of the Exchange Offer; Period for Tendering Old Notes

     This prospectus and the accompanying letter of transmittal contain the
terms and conditions of the exchange offer. Upon the terms and subject to the
conditions included in this prospectus and in the accompanying letter of
transmittal, which together constitute the exchange offer, we will accept for
exchange old notes which are properly tendered on or prior to the expiration
date, unless you have withdrawn them as permitted below:

     o    when you tender to us old notes as provided below, our acceptance of
          the old notes will constitute a binding agreement between you and us
          upon the terms and subject to the conditions in this prospectus and
          in the accompanying letter of transmittal.

     o    for each $1,000 principal amount of old notes surrendered to us
          pursuant to the exchange offer, we will give you $1,000 principal
          amount of new notes. Interest on each new note will accrue from the
          date of issuance of the old note for which the new note is exchanged
          or from the date of the last periodic payment of interest on such old
          note, whichever is later. No additional interest will be paid on old
          notes tendered and accepted for exchange.

     o    we will keep the exchange offer open for not less than 30 days, or
          longer if required by applicable law, after the date that we first
          mail notice of the exchange offer to the holders of the old notes. We
          are sending this prospectus, together with the letter of transmittal,
          on or about the date of this prospectus to all of the registered
          holders of old notes at their addresses listed in the trustee's
          security register with respect to old notes.


     o    the exchange offer expires at 5:00 p.m., New York City time, on ,
          1999; provided, however, that we, in our sole discretion, may extend
          the period of time for which the exchange offer is open. The term

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<PAGE>



     "expiration date" means                 , 2000 or, if extended by us, the
     latest time and date to which the exchange offer is extended.


     o    as of the date of this prospectus, $150,000,000 in aggregate
          principal amount of the old notes were outstanding. The exchange
          offer is not conditioned upon any minimum principal amount of old
          notes being tendered.

     o    our obligation to accept old notes for exchange pursuant to the
          exchange offer is subject to conditions that we describe in the
          section below called "--Conditions to the Exchange Offer".

     o    we expressly reserve the right, at any time, to extend the period of
          time during which the exchange offer is open, and thereby delay
          acceptance of any old notes, by giving oral or written notice of such
          extension to the exchange agent and notice of such extension to the
          holders as described below. During any such extension, all old notes
          previously tendered will remain subject to the exchange offer and may
          be accepted for exchange by us. Any old notes not accepted for
          exchange for any reason will be returned without expense to the
          tendering holder thereof as promptly as practicable after the
          expiration or termination of the exchange offer.

     o    we expressly reserve the right to amend or terminate the exchange
          offer, and not to accept for exchange any old notes that we have not
          yet accepted for exchange, upon the occurrence of any of the
          conditions of the exchange offer specified below under "--Conditions
          to the Exchange Offer."

     o    we will give oral or written notice of any extension, amendment,
          termination or non-acceptance described above to holders of the old
          notes as promptly as practicable. If we extend the expiration date,
          we will give notice by means of a press release or other public
          announcement no later than 9:00 a.m., New York City Time, on the
          business day after the previously scheduled expiration date. Without
          limiting the manner in which we may choose to make any public
          announcement and subject to applicable law, we will have no
          obligation to publish, advertise or otherwise communicate any such
          public announcement other than by issuing a release to the Dow Jones
          News Service.

     o    holders of old notes do not have any appraisal or dissenters' rights
          in connection with the exchange offer.

     o    old notes which are not tendered for exchange or are tendered but not
          accepted in connection with the exchange offer will remain
          outstanding and be entitled to the benefits of the indenture, but
          will not be entitled to any further registration rights under the
          registration rights agreement.

     o    we intend to conduct the exchange offer in accordance with the
          applicable requirements of the Exchange Act and the rules and
          regulations of the SEC thereunder.

     o    by executing, or otherwise becoming bound by, the letter of
          transmittal, you will be making representations to us. See "--Resales
          of the New Notes."

     Important rules concerning the exchange offer

     You should note that:

     o    we will determine all questions as to the validity, form,
          eligibility, including time of receipt, and acceptance of old notes
          tendered for exchange in our sole discretion, which determination
          shall be final and binding.

     o    we reserve the absolute right to reject any and all tenders of any
          particular old notes not properly tendered or to not accept any
          particular old notes which acceptance might, in our judgment or the
          judgment of our counsel, be unlawful.

                                      105


<PAGE>



     o    we also reserve the absolute right to waive any defects or
          irregularities or conditions of the exchange offer as to any
          particular old notes either before or after the expiration date,
          including the right to waive the ineligibility of any holder who
          seeks to tender old notes in the exchange offer. Unless we agree to
          waive any defect or irregularity in connection with the tender of old
          notes for exchange, such waiver must be cured within such reasonable
          period of time as we shall determine.

     o    our interpretation of the terms and conditions of the exchange offer
          as to any particular old notes either before or after the expiration
          date, including the letter of transmittal and the instructions
          thereto, shall be final and binding on all parties.

     o    neither Charles River, the exchange agent nor any other person shall
          be under any duty to give notification of any defect or irregularity
          with respect to any tender of old notes for exchange, nor shall any
          of them incur any liability for failure to give such notification.

Procedures for Tendering Old Notes

     What to submit and how

     If you, as the registered holder of an old note, wish to tender your old
notes for exchange pursuant to the exchange offer, you must transmit a properly
completed and duly executed letter of transmittal, including all other documents
required by such letter of transmittal, to State Street Bank and Trust Company
at the address set forth below under "Exchange Agent" on or prior to the
expiration date.

     In addition,

          (1) certificates for such old notes must be received by the exchange
     agent along with the letter of transmittal, or

          (2) a timely confirmation of a book-entry transfer (what we call a
     "book-entry confirmation") of such old notes, if such procedure is
     available, into the exchange agent's account at DTC pursuant to the
     procedure for book-entry transfer described below, must be received by the
     exchange agent prior to the expiration date or

          (3) you must comply with the guaranteed delivery procedures described
     below.

     The method of delivery of old notes, letters of transmittal and all other
required documents is at your election and risk. If such delivery is by mail, we
recommend that registered mail, properly insured, with return receipt requested,
be used. In all cases, sufficient time should be allowed to assure timely
delivery. No letters of transmittal or old notes should be sent to Charles
River.

     How to sign your letter of transmittal and other documents

     Signatures on a letter of transmittal or a notice of withdrawal, as the
case may be, must be guaranteed unless the old notes surrendered for exchange
pursuant thereto are tendered

          (1) by a registered holder of the old notes who has not completed the
     box entitled "Special Issuance Instructions" or "Special Delivery
     Instructions" on the letter of transmittal or

          (2) for the account of an Eligible Institution (as defined below).

If signatures on a letter of transmittal or a notice of withdrawal, as the case
may be, are required to be guaranteed, such guarantees must be by an eligible
institution that is:

                                      106


<PAGE>



     o    a member of or participant in the Securities Transfer Agents
          Medallion Program or the New York Stock Exchange Medallion Signature
          Program, or

     o    an "eligible guarantor institution" within the meaning of Rule
          17Ad-15 under the Exchange Act (an "Eligible Institution").

     If old notes are registered in the name of a person other than the person
signing the letter of transmittal, the old notes surrendered for exchange must
be endorsed by, or be accompanied by, a written instrument or instruments of
transfer or exchange, in satisfactory form as determined by us in our sole
discretion, duly executed by the registered holder with the signature thereon
guaranteed by an Eligible Institution.

     If the letter of transmittal is signed by a person or persons other than
the registered holder or holders of old notes, such old notes must be endorsed
or accompanied by appropriate powers of attorney, in either case signed exactly
as the name or names of the registered holder or holders that appear on the old
notes.

     If the letter of transmittal or any old notes or powers of attorney are
signed by trustees, executors, administrators, guardians, attorneys-in-fact,
officers or corporations or others acting in a fiduciary or representative
capacity, such person should so indicate when signing and, unless waived by
Charles River, proper evidence satisfactory to Charles River of its authority to
so act must be submitted.

Acceptance of Old Notes for Exchange; Delivery of New Notes

     Upon satisfaction or waiver of all of the conditions to the exchange offer,
we will accept, promptly after the expiration date, all old notes properly
tendered and will issue the new notes promptly after acceptance of the old
notes. See "--Conditions to the Exchange Offer" below. For purposes of the
exchange offer, we shall be deemed to have accepted properly tendered old notes
for exchange when, as and if we have given oral or written notice thereof to the
Exchange Agent.

     In all cases, we will only issue new notes in exchange for old notes that
are accepted for exchange after timely receipt by the exchange agent of:

     o    certificates for such old notes or

          o    a timely book-entry confirmation of such old notes into the
               exchange agent's account at DTC pursuant to the book-entry
               transfer procedures described below, and

          o    a properly completed and duly executed letter of transmittal and
               all other required documents.

     If we do not accept any tendered old notes for any reason included in the
terms and conditions of the exchange offer or if you submit certificates
representing old notes in a greater principal amount than you wish to exchange,
we will return such unaccepted or non-exchanged old notes without expense to the
tendering holder or, in the case of old notes tendered by book-entry transfer
into the exchange agent's account at DTC pursuant to the book-entry transfer
procedures described below, such non-exchanged old notes will be credited to an
account maintained with DTC as promptly as practicable after the expiration or
termination of the exchange offer.

Book-Entry Transfer

     The exchange agent will make a request to establish an account with respect
to the old notes at DTC for purposes of the exchange offer promptly after the
date of this prospectus. Any financial institution that is a Participant in
DTC's systems may make book-entry delivery of old notes by causing DTC to
transfer such old notes into the exchange agent's account in accordance with
DTC's Automated Tender Offer Program ("ATOP") procedures for transfer. However,
the exchange for the old notes so tendered will only be made after timely
confirmation of such book-entry transfer of old notes into the exchange agent's
account, and timely receipt by the exchange agent of an Agent's Message

                                      107


<PAGE>



(as defined in the next sentence) and any other documents required by the letter
of transmittal. The term "Agent's Message" means a message, transmitted by DTC
and received by the exchange agent and forming a part of a Book-Entry
Confirmation, which states that DTC has received an express acknowledgment from
a Participant tendering old notes that are the subject of such Book-Entry
Confirmation that such Participant has received and agrees to be bound by the
terms of the letter of transmittal, and that we may enforce such agreement
against such Participant. Although delivery of old notes may be effected through
book-entry transfer into the exchange agent's account at DTC, the letter of
transmittal, or facsimile thereof, properly completed and duly executed, with
any required signature guarantees and any other required documents, must in any
case be delivered to and received by the exchange agent at its address set forth
under "--Exchange Agent" on or prior to the expiration date, or the guaranteed
delivery procedure set forth below must be complied with.

     Delivery of documents to DTC in accordance with its procedures does not
constitute delivery to the exchange agent.

Guaranteed Delivery Procedures

     If you are a registered holder of old notes and you want to tender such old
notes but your old notes are not immediately available, or time will not permit
your old notes or other required documents to reach the exchange agent before
the expiration date, or the procedure for book-entry transfer cannot be
completed on a timely basis, a tender may be effected if

          (1) the tender is made through an Eligible Institution,

          (2) prior to the expiration date, the exchange agent receives from
     such Eligible Institution a properly completed and duly executed letter of
     transmittal, or a facsimile thereof, and notice of guaranteed delivery,
     substantially in the form provided by us by facsimile transmission, mail
     or hand delivery, stating:

               o    the name and address of the holder of old notes

               o    the amount of old notes tendered

               o    the tender is being made by delivering such notice and
                    guaranteeing that within five New York Stock Exchange
                    trading days after the date of execution of the notice of
                    guaranteed delivery, the certificates of all physically
                    tendered old notes, in proper form for transfer, or a
                    book-entry confirmation, as the case may be, and any other
                    documents required by the letter of transmittal will be
                    deposited by that Eligible Institution with the exchange
                    agent and

          (3) the certificates for all physically tendered old notes, in proper
     form for transfer, or a book-entry confirmation, as the case may be, and
     all other documents required by the letter of transmittal, are received by
     the exchange agent within five New York Stock Exchange trading days after
     the date of execution of the notice of guaranteed delivery.

Withdrawal Rights

     You can withdraw your tender of old notes at any time prior to the
expiration date.

     For a withdrawal to be effective, a written notice of withdrawal must be
received by the exchange agent at one of the addresses listed below under
"--Exchange Agent." Any such notice of withdrawal must specify:

     o    the name of the person having tendered the old notes to be withdrawn.

     o    the old notes to be withdrawn, including the principal amount of such
          old notes.

                                      108


<PAGE>



     o    if certificates for old notes have been delivered to the exchange
          agent, the name in which such old notes are registered, if different
          from that of the withdrawing holder.

     o    if certificates for old notes have been delivered or otherwise
          identified to the exchange agent, then, prior to the release of such
          certificates, you must also submit the serial numbers of the
          particular certificates to be withdrawn and a signed notice of
          withdrawal with signatures guaranteed by an Eligible Institution
          unless you are an Eligible Institution.

     o    if old notes have been tendered pursuant to the procedure for
          book-entry transfer described above, any notice of withdrawal must
          specify the name and number of the account at DTC to be credited with
          the withdrawn old notes and otherwise comply with the procedures of
          such facility.

     Please note that all questions as to the validity, form and eligibility,
including time of receipt, of such notices of withdrawal will be determined by
us, and our determination shall be final and binding on all parties. Any old
notes so withdrawn will be deemed not to have been validly tendered for exchange
for purposes of the exchange offer.

     If you have properly withdrawn old notes and wish to re-tender them, you
may do so by following one of the procedures described under "--Procedures for
Tendering Old Notes" above at any time on or prior to the expiration date.

Conditions to the Exchange Offer

     Notwithstanding any other provisions of the exchange offer, we will not be
required to accept for exchange, or to issue new notes in exchange for, any old
notes and may terminate or amend the exchange offer, if at any time before the
acceptance of such old notes for exchange or the exchange of the new notes for
such old notes, such acceptance or issuance would violate applicable law or any
interpretation of the staff of the SEC.

     The foregoing condition is for our sole benefit and may be asserted by us
regardless of the circumstances giving rise to such condition. Our failure at
any time to exercise the foregoing rights shall not be deemed a waiver by us of
any such right and each such right shall be deemed an ongoing right which may be
asserted at any time and from time to time.

     In addition, we will not accept for exchange any old notes tendered, and no
new notes will be issued in exchange for any such old notes, if at such time any
stop order shall be threatened or in effect with respect to the exchange offer
of which this prospectus constitutes a part or the qualification of the
indenture under the Trust Indenture Act.

Exchange Agent

     State Street Bank and Trust Company has been appointed as the exchange
agent for the exchange offer. All executed letters of transmittal should be
directed to the exchange agent at one of the addresses set forth below.
Questions and requests for assistance, requests for additional copies of this
prospectus or of the letter of transmittal and requests for notices of
guaranteed delivery should be directed to the exchange agent, addressed as
follows:

                                         Deliver To:

By Overnight Courier or Hand:              By Registered or Certified Mail:
State Street Bank and Trust Company        State Street Bank and Trust Company
Corporate Trust Department                 Corporate Trust Department
Two Avenue de Lafayette                    Two Avenue de Lafayette
Boston, Massachusetts 02111-1724           Boston, Massachusetts 02111-1724
Fifth Floor                                Fifth Floor
Attn: Kellie Mullen                        Attn: Kellie Mullen
Telephone: (617) 662-1525                  Telephone: (617) 662-1525
Facsimile: (617) 662-1450                  Facsimile: (617) 662-1450



                                      109


<PAGE>



     Delivery to an address other than as listed above or transmission of
instructions via facsimile other than as listed above does not constitute a
valid delivery.

Fees and Expenses

     The principal solicitation is being made by mail; however, additional
solicitation may be made by telegraph, telephone or in person by our officers,
regular employees and affiliates. We will not pay any additional compensation to
any such officers and employees who engage in soliciting tenders. We will not
make any payment to brokers, dealers, or others soliciting acceptances of the
exchange offer. However, we will pay the exchange agent reasonable and customary
fees for its services and will reimburse it for its reasonable out-of-pocket
expenses in connection therewith.

     The estimated cash expenses to be incurred in connection with the exchange
offer will be paid by us and are estimated in the aggregate to be $.4 million.

Transfer Taxes

     Holders who tender their old notes for exchange will not be obligated to
pay any transfer taxes in connection therewith, except that holders who instruct
us to register new notes in the name of, or request that old notes not tendered
or not accepted in the exchange offer be returned to, a person other than the
registered tendering holder will be responsible for the payment of any
applicable transfer tax thereon.

Resale of the New Notes

     Under existing interpretations of the staff of the SEC contained in several
no-action letters to third parties, the new notes would in general be freely
transferable after the exchange offer without further registration under the
Securities Act. However, any purchaser of old notes who is an "affiliate" of
Charles River or who intends to participate in the exchange offer for the
purpose of distributing the new notes

     (1)  will not be able to rely on the interpretation of the staff of the
          SEC,

     (2)  will not be able to tender its old notes in the exchange offer and

     (3)  must comply with the registration and prospectus delivery
          requirements of the Securities Act in connection with any sale or
          transfer of the notes unless such sale or transfer is made pursuant
          to an exemption from such requirements.

     By executing, or otherwise becoming bound by, the letter of transmittal,
each holder of the old notes, other than specified holders, will represent that:

     (1)  it is not our "affiliate";

     (2)  any new notes to be received by it were acquired in the ordinary
          course of its business; and

     (3)  it has no arrangement with any person to participate in the
          distribution, within the meaning of the Securities Act, of the new
          notes.

In addition, in connection with any resales of new notes, any broker-dealer
participating in the exchange offer who acquired notes for its own account as a
result of market-making or other trading activities must deliver a prospectus
meeting the requirements of the Securities Act. The SEC has taken the position
that participating broker-dealers may fulfill their prospectus delivery
requirements with respect to the new notes, other than a resale of an unsold
allotment from the original sale of the old notes, with this prospectus. Under
the registration rights agreement, we are required to allow participating
broker-dealers and other persons, if any, subject to similar prospectus delivery
requirements to use

                                      110


<PAGE>



this prospectus as it may be amended or supplemented from time to time, in
connection with the resale of such new notes.

         CERTAIN FEDERAL INCOME TAX CONSEQUENCES OF THE EXCHANGE OFFER

     The exchange of old notes for new notes pursuant to the exchange offer will
not result in any United States federal income tax consequences to holders. When
a holder exchanges an old note for a new note pursuant to the exchange offer,
the holder will have the same adjusted basis and holding period in the new note
as in the old note immediately before the exchange.

                              PLAN OF DISTRIBUTION

     Each broker-dealer that receives new notes for its own account pursuant to
the exchange offer must acknowledge that it will deliver a prospectus in
connection with any resale of such new notes. This prospectus, as it may be
amended or supplemented from time to time, may be used by a broker-dealer in
connection with resales of new notes received in exchange for old notes where
such old notes were acquired as a result of market-making activities or other
trading activities. We have agreed that we will make this prospectus, as amended
or supplemented, available to any participating broker-dealer for use in
connection with any such resale and participating broker-dealers shall be
authorized to deliver this prospectus for a period not exceeding 90 days after
the exchange offer expiration date.

     We will not receive any proceeds from any sale of new notes by
broker-dealers. New notes received by broker-dealers for their own account
pursuant to the exchange offer may be sold from time to time in one or more
transactions in the over-the-counter market, in negotiated transactions, through
the writing of options on the new notes or a combination of such methods of
resale, at market prices prevailing at the time of resale, at prices related to
such prevailing market prices or negotiated prices. Any such resale may be made
directly to purchasers or to or through brokers or dealers who may receive
compensation in the form of commissions or concessions from any such
broker-dealer or the purchasers of any such new notes. Any broker-dealer that
resells new notes that were received by it for its own account pursuant to the
exchange offer and any broker or dealer that participates in a distribution of
such new notes may be deemed to be an "underwriter" within the meaning of the
Securities Act and any profit on any such resale of new notes and any commission
or concessions received by any such persons may be deemed to be underwriting
compensation under the Securities Act. The letter of transmittal states that, by
acknowledging that it will deliver and by delivering a prospectus, a
broker-dealer will not be deemed to admit that it is an "underwriter" within the
meaning of the Securities Act.

     For a period of 90 days after the exchange offer expiration date, we will
promptly send additional copies of this prospectus and any amendment or
supplement to this prospectus to any Participating Broker-Dealer that requests
such documents in the letter of transmittal. See "The Exchange Offer." We have
agreed to pay all expenses incident to the exchange offer and will indemnify
holders of the old notes (including any broker-dealers) against some
liabilities, including some liabilities under the Securities Act.

                                      111


<PAGE>



                                 LEGAL MATTERS

     The validity of the new notes offered hereby will be passed upon for
Charles River Laboratories, Inc. and Charles River Laboratories Holdings, Inc.
by Davis Polk & Wardwell, New York, New York.

                            INDEPENDENT ACCOUNTANTS

     The consolidated financial statements of Charles River Laboratories, Inc.
and the combined financial statements of Charles River Laboratories Holdings,
Inc. and Charles River Laboratories, Inc. as of December 27, 1997 and December
26, 1998 and for each of the three years in the period ended December 26, 1998
included in this prospectus have been audited by PricewaterhouseCoopers LLP as
stated in their report appearing herein.

                      WHERE YOU CAN FIND MORE INFORMATION

     We have filed with the SEC a registration statement on Form S-1 under the
Securities Act with respect to our offering of the new notes. This prospectus
does not contain all the information included in the registration statement and
the related exhibits and schedules. You will find additional information about
us and the new notes in the registration statement. The registration statement
and the related exhibits and schedules may be inspected and copied at the
public reference facilities maintained by the SEC at Room 1024, Judiciary
Plaza, 450 Fifth Street, N.W., Washington, D.C. 20549, and at the public
reference facilities of the SEC's Regional Offices: New York Regional Office,
Seven World Trade Center, Suite 1300, New York, New York 10048; and Chicago
Regional Office, Citicorp Center, 500 West Madison Street, Chicago, Illinois
60661. Copies of this material may also be obtained from the Public Reference
Section of the SEC at 450 Fifth Street, N.W., Washington, D.C. 20549 at
prescribed rates. You can obtain information on the operation of the public
reference facilities by calling 1-800-SEC-0330. The SEC also maintains a site
on the World Wide Web (http://www.sec.gov) that contains reports, proxy and
information statements and other information regarding registrants, including
Charles River, that file electronically with the SEC. Statements made in this
prospectus about legal documents may not necessarily be complete and you should
read the documents which are filed as exhibits or schedules to the registration
statement or otherwise filed with the SEC.


  The indenture governing the notes obligates us to furnish the holders of
notes with all quarterly and annual financial information that would be required
to be contained in a filing with the SEC on forms 10-Q and 10-K if Charles River
were required to file such Forms, including, without limitation, (a)
"Management's Discussion and Analysis of Financial Condition and Results of
Operations" and, with respect to the annual information only, a report thereon
by Charles River's certified independent accountants, and (b) all current
reports that would be required to be filed with the SEC on Form 8-K if Charles
River were required to file such reports, in each case, within the time periods
specified in the SEC's rules and regulations.


                                      112


<PAGE>



       INDEX TO UNAUDITED PRO FORMA CONDENSED CONSOLIDATED FINANCIAL DATA

<TABLE>

                                                                                                                 Page
                                                                                                                 ----
<S>                                                                                                              <C>

Introduction to Unaudited Pro Forma Condensed Consolidated Financial Data.....................................    P-2

Charles River Laboratories, Inc. and Subsidiaries

Unaudited Pro Forma Condensed Consolidated Balance Sheet as of September 25, 1999.............................    P-4

Notes to Unaudited Pro Forma Condensed Consolidated Balance Sheet as of September 25, 1999....................    P-5

Unaudited Pro Forma Condensed Consolidated Statement of Income for the Year Ended December 26,
     1998.....................................................................................................    P-8

Unaudited Pro Forma Condensed Consolidated Statement of Income for the Nine Months Ended
     September 26, 1998.......................................................................................    P-9

Unaudited Pro Forma Condensed Consolidated Statement of Income for the Nine Months Ended
     September 25, 1999.......................................................................................    P-10

Notes to Unaudited Pro Forma Condensed Consolidated Statements of Income......................................    P-11
</TABLE>


                                      P-1


<PAGE>


                 INTRODUCTION TO UNAUDITED PRO FORMA CONDENSED
                          CONSOLIDATED FINANCIAL DATA

     On September 29, 1999, Charles River Laboratories, Inc. (the "Company" or
"Charles River") consummated a recapitalization transaction pursuant to a
recapitalization agreement dated as of July 25, 1999 (the "Recapitalization
Agreement") with Bausch & Lomb Incorporated ("B&L"), certain subsidiaries of B&L
(such subsidiaries and B&L are referred to, collectively, as the "Rollover
Shareholders"), Endosafe, Inc. (renamed Charles River Laboratories Holdings,
Inc., referred to as "Holdings") and CRL Acquisition LLC, a subsidiary of DLJ
Merchant Banking Partners II, L.P. ("DLJMB"). Prior to the consummation of the
Recapitalization, the Company became a wholly owned subsidiary of Holdings.
Holdings has no operations other than those related to Charles River. Holdings
was recapitalized in a transaction providing aggregate consideration of $456.2
million, consisting of $400.0 million in cash, a subordinated discount note for
$43.0 million to be issued by Holdings to the Rollover Shareholders and equity
to be retained by the Rollover Shareholders with a fair market value of $13.2
million (the "Recapitalization"). The $400.0 million cash consideration was
raised through the following:

     o    $92.4 million cash equity investment in Holdings by DLJMB and certain
          of its affiliated funds (collectively, "the DLJMB Funds"), management
          and certain other investors

     o    $37.6 million senior discount debentures with warrants issued by
          Holdings to DLJMB and some of its affiliates and other investors

     o    $162.0 million senior secured credit facilities at the Company

     o    a portion of the net proceeds of the Company's units offered hereby


     Upon the consummation of the Recapitalization, the DLJMB Funds, management
and certain other investors owned 87.5% of the outstanding capital stock of
Holdings and B&L owned 12.5% of the outstanding capital stock of Holdings. The
Recapitalization has been accounted for as a leveraged recapitalization, which
will have no impact on the historical basis of Holdings' and, accordingly
Charles River's, assets and liabilities.

     Simultaneously with the Recapitalization, the Company acquired SBI
Holdings, Inc. ("Sierra") pursuant to a stock purchase agreement (the "Sierra
Acquisition") for an initial total purchase price of $24.0 million, including
approximately $18.0 million in cash paid to former shareholders and assumed debt
of approximately $6.0 million, which we immediately retired. The Company funded
the acquisition with available cash, a portion of the net proceeds from the
notes offered hereby and a portion of the borrowings under our new credit
facility. In addition, the Company has agreed to pay (a) up to $2.0 million in
contingent consideration if certain financial objectives are reached by December
31, 2000, (b) up to $10.0 million in performance-based bonus payments if certain
financial objectives are reached over the next five years, and (c) $3.0 million
in retention and non-competition payments contingent upon the continuing
employment of certain key scientific and managerial personnel through June 30,
2001. The Recapitalization and the Sierra Acquisition are collectively referred
to as the "Transactions." The Recapitalization and the Sierra Acquisition were
consummated concurrently.

     The following unaudited pro forma condensed consolidated financial data of
the Company is based upon historical consolidated financial statements of
Charles River as adjusted to give effect to the impact of the Transactions and
the application of the related net proceeds therefrom as discussed under the
captions "Transactions" and "Use of Proceeds." The unaudited pro forma condensed
consolidated balance sheet as of September 25, 1999 gives effect to the
Transactions assuming that the Transactions had occurred on September 25, 1999.
The unaudited pro forma condensed consolidated statements of income for the year
ended December 26, 1998, the nine months ended September 26, 1998, and the nine
months ended September 25, 1999 give effect to the Transactions as if they had
occurred at the beginning of the period presented. The unaudited pro forma
condensed consolidated statements of income for the twelve months ended December
26, 1998, and the nine months ended September 26, 1998 also give effect to the
Tektagen, Therion and ESD Acquisitions (the "1998 Acquisitions") as if they all
had occurred at the beginning of the period presented.



                                      P-2


<PAGE>


     The pro forma adjustments are based on estimates, available information and
certain assumptions and may be revised as additional information becomes
available. The unaudited pro forma condensed consolidated financial data do not
purport to represent what Charles River results of operations or financial
position would actually have been if the Transactions and other adjustments had
occurred on the dates indicated and are not necessarily representative of
Charles River results of operations for any future period. The unaudited pro
forma condensed consolidated balance sheet and consolidated statements of income
should be read in conjunction with our consolidated financial statements and the
notes thereto, "Management's Discussion and Analysis of Financial Condition and
Results of Operations" and the other financial information appearing elsewhere
in this prospectus.

                                      P-3



<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
            UNAUDITED PRO FORMA CONDENSED CONSOLIDATED BALANCE SHEET
                            As of September 25, 1999
                             (dollars in thousands)

<TABLE>
                                                                                                         Sierra
                                               Settlement                      Pro Forma        -------------------------
                                 Company          with       Recapitalization    for the                      Acquisition
                                Historical        B&L(a)       Adjustments    Recapitalization  Historical(b) Adjustments Pro Forma
                                ----------     ----------    ---------------- ----------------  ------------- ----------- ---------
<S>                             <C>            <C>            <C>               <C>             <C>           <C>          <C>
Assets
Current assets:
   Cash and cash equivalents    $   3,457      $  2,437       $ 21,827(c)       $ 27,721        $    292     $(24,335)(d) $   3,678
   Trade receivables........       33,820            --             --            33,820           2,493           --        36,313
   Inventories..............       28,577            --             --            28,577             853          131 (d)    29,561
   Deferred income taxes....        5,432        (5,432)            --                --              --           --            --
   Due from affiliates......          966            --             --               966              --           --           966
   Other current assets.....        5,051            --             --             5,051             791           --         5,842
                                ---------      --------       --------          --------        --------     --------     ---------
   Total current assets.....       77,303        (2,995)        21,827            96,135          4 ,429      (24,204)       76,360

Property, plant and
   equipment, net...........       79,349            --             --            79,349           4,918          280 (d)    84,547
Goodwill and other
   intangibles, net.........       16,212            --             --            16,212           4,919       16,889 (d)    38,020
Investments in affiliates...       19,385            --             --            19,385              --           --        19,385
Deferred tax assets.........        5,787        (5,787)        88,060(e)         88,060              --           --        88,060
Other assets................       12,335            --         13,237(c)         25,572             254           -- (d)    25,826
                                ---------      --------       --------          --------        --------     --------     ---------
   Total assets.............    $ 210,371      $ (8,782)      $123,124          $324,713        $ 14,520       (7,035)    $ 332,198
                                =========      ========       ========          ========        ========     ========     =========
Liabilities and
   Shareholder's Equity
   Current Liabilities:
   Current portion of long-
      term debt.............    $     166      $     --       $  1,200(c)       $  1,366        $  1,729     $ (1,729)(d) $   1,366
   Current portion of
      capital lease
      obligations...........          167            --             --               167             105           --           272
   Accounts payable.........        5,992            --             --             5,992           1,134           --         7,126
   Accrued compensation.....       11,015            --             --            11,015             569           --        11,584
   Accrued ESLIRP...........        5,845            --             --             5,845              --           --         5,845
   Accrued restructuring....          354            --             --               354              --           --           354
   Deferred income..........        4,550            --             --             4,550              --           --         4,550
   Accrued liabilities......       12,410            --             --            12,410             852           --        13,262
   Accrued income taxes.....       16,208       (16,208)            --                --              --           --            --
                                ---------      --------       --------          --------        --------     --------     ---------
   Total current liabilities       56,707       (16,208)         1,200            41,699           4,389       (1,729)       44,359

Long-term debt..............           --            --        308,672(c)        308,672           4,240       (4,240)(d)   308,672
Long-term capital lease
   obligations..............          700            --             --               700             118           --           818
Other long-term liabilities.        3,706            --             --             3,706             333           --         4,039
                                ---------      --------       --------          --------        --------     --------     ---------
Deferred income tax
   liability................           --            --             --                --              --        4,374 (d)     4,374
                                ---------      --------       --------          --------        --------     --------     ---------
   Total liabilities........       61,113       (16,208)       309,872           354,777           9,080       (1,595)      362,262
                                ---------      --------       --------          --------        --------     --------     ---------
Minority interests..........          293            --             --               293              --           --           293
Shareholder's equity
   Common stock.............            1            --             --                 1              --           --             1
   Capital in excess of par
      value.................       17,836            --         88,060(e)        105,896           4,667       (4,667)(d)   105,896
   Retained earnings
      (accumulated deficit).      142,422         7,426       (273,888)(c)      (124,040)          4,057       (4,057)(d)  (124,040)
   Treasury stock, at cost..           --            --             --                --          (3,284)       3,284 (d)        --


                                      P-4


<PAGE>


                                                                                                         Sierra
                                               Settlement                      Pro Forma        -------------------------
                                 Company          with       Recapitalization    for the                      Acquisition
                                Historical        B&L(a)       Adjustments    Recapitalization  Historical(b) Adjustments Pro Forma
                                ----------     ----------    ---------------- ----------------  ------------- ----------- ---------
<S>                             <C>            <C>            <C>               <C>             <C>           <C>          <C>
   Loans to officers........                                      (920)(c)          (920)                                      (920)
   Accumulated other
      comprehensive
      income (accumulated
      deficit)..............      (11,294)          --              --           (11,294)             --           --       (11,294)
                                ---------      --------       --------          --------        --------     --------     ---------
   Total shareholder's equity     148,965         7,426       (186,748)          (30,357)          5,440       (5,440)      (30,357)
                                ---------      --------       --------          --------        --------     --------     ---------
   Total liabilities and
      shareholder's equity      $ 210,371      $ (8,782)      $123,124          $324,713        $ 14,520     $ (7,035)    $ 332,198
                                =========      ========       ========          ========        ========     ========     =========
- -------------------
(a)  Represents assets and liabilities of Charles River as of September 25,
     1999 that, according to the terms of the Recapitalization Agreement, were
     distributed to or assumed by B&L in conjunction with the closing of the
     Recapitalization and, accordingly, are not part of the ongoing operations
     of Charles River. In addition, the adjustment includes a cash settlement
     paid by B&L to Charles River in accordance with the terms of the
     Recapitalization Agreement.

(b)  Reflects Sierra's historical unaudited consolidated balance sheet at
     September 25, 1999.

(c)  Holdings was recapitalized as described under the caption "Transactions."
     The Company's portion of the sources and uses of cash required to
     consummate the Transactions as of September 25, 1999 follow:
</TABLE>

Sources:
Available cash..........................................$  2,173
New credit facility
     Revolving credit facility..........................   2,000
     Term loans......................................... 160,000
Units:  Senior subordinated notes   147,872
        Warrants(1)                   2,128............. 150,000
                                                        --------
     Total cash sources.................................$314,173
                                                        ========
Uses:
Distribution to Holdings................................$270,000
Cash consideration for Sierra acquisition...............  24,000
Debt issuance costs.....................................  13,237
Estimated transaction fees and expenses(2)..............   6,016
Loans to officer........................................     920
                                                        --------
     Total cash uses....................................$314,173
                                                        ========
- -------------------
(1)  The fair value of the related warrants was estimated at $2,128.

(2)  Consists of bridge facility commitment, legal and other professional fees.
     Does not include fees associated with the Sierra Acquisition (see note (d)
     below).

     The following represents a reconciliation of the amounts presented in the
     sources and uses table above to the pro forma adjustments included in the
     unaudited pro forma condensed consolidated balance sheet:


                                      P-5
<PAGE>


Adjustment to cash and cash equivalents:

     Sources: Revolving credit facility..................    $       2,000
              Term loans.................................          160,000
              Units......................................          150,000
     Uses:    Distribution to Holdings...................         (270,000)
              Debt issuance costs........................          (13,237)
              Estimated transaction fees and expenses....           (6,016)
              Loans to officers..........................             (920)
                                                             -------------
                                                             $      21,827
                                                             =============
Adjustments to other assets:

              Debt issuance costs........................    $      13,237
                                                             =============
Adjustments to debt:

               Revolving credit facility..................   $       2,000
               Term loans.................................         160,000
               Senior subordinated notes..................         147,872
                                                             -------------
                                                                   309,872
                    Less current portion..................          (1,200)
                                                             -------------
                    Long-term debt........................   $     308,672
                                                             =============
Adjustments to retained earnings:

              Distribution to Holdings...................    $    (270,000)
              Estimated transaction fees and expenses....           (6,016)
              Estimated fair value of warrants...........            2,128
                                                             -------------
                                                             $    (273,888)
                                                             =============
Adjustments to loans to officers:

             ..........................................      $         920
                                                             =============

(d)  Reflects the Sierra Acquisition adjustments. The sources and uses of cash
     which were required to consummate the Sierra Acquisition on September 29,
     1999 follow:

Sources:
Available cash.........................................$24,335
                                                       -------
     Total cash sources................................$24,335
                                                       =======
Uses:
Sierra acquisition consideration(1)....................$24,000
Estimated transaction fees and expenses(2).............    335
                                                       -------
     Total cash uses...................................$24,335
                                                       =======
- -------------------
(1)  Approximately $6,000 will be used to repay Sierra's existing debt.

(2) Consists of legal and other professional fees.

                                      P-6
<PAGE>


Allocation of purchase price:
Current assets.....................................................  $    4,560
Property, plant and equipment......................................       5,198
Other non-current assets...........................................         254
Intangible assets:
     Customer list.................................     11,491
     Work force....................................      2,941
     Other identifiable intangibles................      1,251
     Goodwill......................................      1,751            17,434
                                                                          27,446
Less assumed liabilities...........................................        3,111
                                                                     -----------
                                                                     $    24,335
                                                                     ===========


     The lives established for the intangible assets acquired range from 5 to
     15 years.

     As a result of the Company buying the stock of Sierra, the historical tax
     basis of Sierra continues with the Company and, as such, a deferred tax
     liability and offsetting goodwill of $4,374 has been recorded.


     In conjunction with the Sierra Acquisition, the Company has agreed to pay
     additional consideration of up to $2,000 if Sierra achieves certain
     financial targets by December 31, 2000. This additional consideration, if
     any, will be recorded as additional goodwill at the time the contingency
     is resolved.

(e)  The adjustment reflects the increase in the deferred tax assets of the
     Company due to the Section 338(h)(10) election made in conjunction with
     the Recapitalization. Such election results in a step-up in the tax basis
     of the underlying assets. The resulting net deferred tax asset of
     approximately $88,060 is expected to be realized over 15 years through
     future tax deductions which are expected to reduce future tax payments. In
     connection with the establishment of this net deferred tax asset,
     management has recorded a valuation allowance of $7,770, primarily related
     to its realizability with respect to state income taxes. Management has
     recorded this net deferred tax asset based on its belief that it is more
     likely than not that it will be realized. This belief is based upon a
     review of all available evidence, including historical operating results,
     projections of future taxable income, and tax planning strategies.



                                      P-7
<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
         UNAUDITED PRO FORMA CONDENSED CONSOLIDATED STATEMENT OF INCOME
                             (dollars in thousands)

<TABLE>
                                              For the Year Ended December 26, 1998(a)
                              --------------------------------------------------------------------------
                                                                                           Pro Forma
                                                                                            for the
                                                                                        Recapitalization
                               Company        1998         Adjusted   Recapitalization    and the 1998
                              Historical  Acquisitions(b) Historical     Adjustments      Acquisitions
                              ----------  --------------  ----------  ----------------  ----------------
<S>                            <C>          <C>            <C>          <C>                 <C>
Net sales related to
 products...................   $169,377     $3,457         $172,834     $     --            $172,834
Net sales related to
 services...................     23,924         --           23,924           --              23,924
Total net sales.............    193,301      3,457          196,758           --             196,758
Cost of products sold.......    107,146      2,716          109,862           --             109,862
Cost of services provided...     15,401         --           15,401           --              15,401
Selling, general and
 administrative expenses(d).     34,142        805           34,947           --              34,947
Amortization of goodwill
 and other intangibles......      1,287        116(e)         1,403           --               1,403
                               --------     ------         --------     --------            --------
Operating income............     35,325       (180)          35,145           --              35,145
Interest income.............        986         --              986         (802)(f)             184
Interest expense............       (421)       (23)            (444)     (36,536)(g)         (36,980)
Loss from foreign currency,
 net........................        (58)        --              (58)          --                 (58)
                               --------     ------         --------     --------            --------
Income (loss) before income
 taxes, minority interests
 and earnings from equity
 investments................     35,832       (203)          35,629      (37,338)             (1,709)
Provision (benefit) for
 income taxe................     14,123        150           14,273      (14,698)(i)            (425)
                               --------     ------         --------     --------            --------
Income (loss) before
 minority interests and
 earnings from equity
 investments................     21,709       (353)          21,356      (22,640)             (1,284)
Minority interests..........        (10)        --              (10)          --                 (10)
Earnings from equity
 investments................      1,679          2            1,681           --               1,681
                               --------     ------         --------     --------            --------
Net income (loss)...........   $ 23,378     $ (351)        $ 23,027     $(22,640)           $    387
                               ========     ======         ========     ========            ========

(FINANCIAL INFORMATION TO BE CONTINUED)

                                      P-8
<PAGE>


(FINANCIAL INFORMATION CONTINUED)


                            For the Year Ended December 26, 1998(a)
                            ---------------------------------------
                                     Sierra
                            -------------------------
                            Historical(c) Adjustments  Pro Forma
                            -----------   -----------  ----------
<S>                           <C>         <C>          <C>
Net sales related to
 products...................  $ 13,135    $     --      $185,969
Net sales related to
 services...................        --          --        23,924
Total net sales.............    13,135          --       209,893
Cost of products sold.......     6,689          --       116,551
Cost of services provided...        --          --        15,401
Selling, general and
 administrative expenses(d).     4,105          --        39,052
Amortization of goodwill
 and other intangibles......        --       1,951(e)      3,354
                              --------    --------      --------
Operating income............     2,341      (1,951)       35,535
Interest income.............        --          --           184
Interest expense............      (191)        191(h)    (36,980)
Loss from foreign currency,
 net........................        --          --           (58)
                              --------    --------      --------
Income (loss) before income
 taxes, minority interests
 and earnings from equity
 investments................     2,150      (1,760)       (1,319)
Provision (benefit) for
 income taxe................       750        (365)(j)       (40)
                              --------    --------      --------
Income (loss) before
 minority interests and
 earnings from equity
 investments................     1,400      (1,395)       (1,279)
Minority interests..........        --          --           (10)
Earnings from equity
 investments................        --          --         1,681
                              --------    --------      --------
Net income (loss)...........  $  1,400    $ (1,395)     $    392
                              ========    ========      ========
</TABLE>

                                      P-8
<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
         UNAUDITED PRO FORMA CONDENSED CONSOLIDATED STATEMENT OF INCOME
                             (dollars in thousands)

<TABLE>
                                               For the Nine Months Ended September 26, 1998(a)
                                --------------------------------------------------------------------------
                                                                                             Pro Forma
                                                                                              for the
                                                                                          Recapitalization
                                 Company        1998         Adjusted   Recapitalization    and the 1998
                                Historical  Acquisitions(b) Historical     Adjustments      Acquisitions
                                ----------  --------------  ----------  ----------------  ----------------
<S>                              <C>            <C>          <C>          <C>                 <C>
Net sales related to products... $128,478       $2,984       $131,462     $     --            $131,462
Net sales related to services...   17,041           --         17,041           --              17,041
                                 --------       ------       --------     --------            --------
Total net sales.................  145,519        2,984        148,503           --             148,503
Cost of products sold...........   80,067        2,436         82,502           --              82,503
Cost of services provided.......   10,974           --         10,974           --              10,974
Selling, general and
   administrative expenses(d)...   25,202          723         25,925           --              25,925
Amortization of goodwill and
   other intangibles............    1,036          116(e)       1,152           --               1,152
                                 --------       ------       --------     --------            --------
Operating income................   28,240         (291)        27,949           --              27,949
Interest income.................      659           --            659         (521)(f)             138
Interest expense................     (311)         (23)          (334)     (27,402)(g)         (27,736)
Loss from foreign currency, net.     (127)          --           (127)          --                (127)
                                 --------       ------       --------     --------            --------
Income (loss) before income
   taxes, minority interests and
   earnings from equity
   investments..................   28,461         (314)        28,147      (27,923)                224
Provision (benefit) for income
   taxes........................   11,280          105         11,385      (11,007)(i)             378
                                 --------       ------       --------     --------            --------
Income (loss) before minority
   interests and earnings from
   equity investments...........   17,181         (419)        16,762      (16,916)               (154)
Minority interests..............      (8)           --             (8)          --                  (8)
Earnings from equity
   investments..................    1,286            2          1,288           --               1,288
                                 --------       ------       --------     --------            --------
Net income (loss)............... $ 18,459       $ (417)      $ 18,042     $(16,916)            $(1,126)
                                 ========       ======       ========     ========             =======

(FINANCIAL INFORMATION TO BE CONTINUED)

                                      P-9
<PAGE>


(FINANCIAL INFORMATION CONTINUED)


                        CHARLES RIVER LABORATORIES, INC.
         UNAUDITED PRO FORMA CONDENSED CONSOLIDATED STATEMENT OF INCOME
                             (dollars in thousands)


                               For the Nine Months Ended September 26, 1998(a)
                               -----------------------------------------------
                                        Sierra
                                 -----------------------
                                 Historical(c)  Adjustments  Pro Forma
                                 ------------   -----------  ----------
<S>                               <C>             <C>         <C>
Net sales related to products...  $ 9,615         $    --     $141,077
Net sales related to services...       --              --       17,041
                                  -------         -------     --------
Total net sales.................    9,615              --      158,118
Cost of products sold...........    4,634              --       87,137
Cost of services provided.......       --              --       10,974
Selling, general and
   administrative expenses(d)...    2,753              --       28,678
Amortization of goodwill and
   other intangibles............       --           1,439(e)     2,591
                                  -------         -------     --------
Operating income................    2,228          (1,439)      28,738
Interest income.................       --              --          138
Interest expense................      (77)             77(h)
Loss from foreign currency, net.       --              --         (127)
Income (loss) before income
   taxes, minority interests and
   earnings from equity
   investments..................    2,151          (1,362)       1,013
Provision (benefit) for income
   taxes........................      703            (300)(j)      781
                                  -------         -------     --------
Income (loss) before minority
   interests and earnings from
   equity investments...........    1,448          (1,062)         232
Minority interests..............                                     (8)
Earnings from equity
   investments..................       --              --        1,288
                                  -------         -------     --------
Net income (loss)...............  $ 1,448         $(1,062)    $  1,512
                                  =======         =======     ========
</TABLE>

                                      P-9


<PAGE>

<TABLE>

                                                    CHARLES RIVER LABORATORIES, INC.
                                   UNAUDITED PRO FORMA CONDENSED CONSOLIDATED STATEMENT OF INCOME

                                                        (dollars in thousands)


                                                       For the Nine Months Ended Septemnber 25, 1999(a)
                                 ----------------------------------------------------------------------------------------------
                                                                                          Sierra                Pro Forma for
                                                                Pro Forma      ----------------------------    Recapitalization
                                  Company   Recapitalization                                                       & Sierra
                                 Historical    Adjustments   Recapitalization  Historical(c)     Adjustments     Acquisition
                                 ---------- ---------------- ----------------  -------------     -----------   ----------------
<S>                              <C>           <C>           <C>               <C>               <C>           <C>

Net sales related to products.    $ 139,269     $      --       $  139,269      $  16,034           $    --        $ 155,303
Net sales related to services.       21,827            --           21,827             --                --           21,827
                                  ---------     ---------       ----------     ----------           -------        ---------
Total net sales...............      161,096            --          161,096         16,034                --          177,130
Cost of products sold.........       84,557            --           84,557          9,589                --           94,146
Cost of services provided.....       12,673            --           12,673             --                --           12,673
Selling, general and
   administrative expenses(d).       29,414            --           29,414          5,364                --           34,778
Amortization of goodwill and
   other intangibles..........        1,114            --            1,114            192             1,247(e)         2,553
                                  ---------     ---------       ----------     ----------           -------        ---------
Operating income..............       33,338            --           33,338            889            (1,247)          32,980
Other income..................        1,441            --            1,441             --                --            1,441
Interest income...............          496          (358)(f)          138             --                --              138
Interest expense..............         (207)      (29,472)(g)      (29,679)          (321)              321(h)       (29,679)
Loss from foreign currency,
     net......................         (143)           --             (143)            --                --             (143)
                                  ---------     ---------       ----------     ----------           -------        ---------
Income (loss) before income
   taxes minority interests
   and earnings from equity
   investments................       34,925       (29,830)           5,095           568               (926)           4,737
Provision (benefit) for income
   taxes......................       16,903       (11,925)(i)        4,978           233               (203)(j)        5,008
                                  ---------     ---------       ----------     ----------           -------        ---------
Income (loss) before minority
   interests and earnings from
   equity investments.........       18,022       (17,905)             117           335               (723)            (271)
Minority interests............          (10)           --              (10)           --                 --              (10)
Earnings from equity
   investments................        1,940            --            1,940            --                 --            1,940
                                  ---------     ---------       ----------     ----------           -------        ---------
Net income (loss).............    $  19,952     $ (17,905)      $    2,047     $     335            $  (723)       $   1,659
                                  =========     =========       ==========     =========            =======        =========
</TABLE>


                                     P-10


<PAGE>




                       CHARLES RIVER LABORATORIES, INC.
                    NOTES TO UNAUDITED PRO FORMA CONDENSED
                       CONSOLIDATED STATEMENTS OF INCOME
                            (dollars in thousands)


(a)  Charles River's fiscal year consists of a twelve month period ending on the
     Saturday closest to December 31; the Company's nine month periods consist
     of the nine months ending on the Saturday closest to September 30.

(b)  Represents the financial results for the companies acquired during 1998 for
     the periods not included in the Company Historical column as follows:
     Tektagen (from January 1, 1998 until March 31, 1998), Therion (from January
     1, 1998 until March 31, 1998) and ESD (from January 1, 1998 until November
     30, 1998). The tables below detail these results for the year ended
     December 26, 1998 and the nine months ended September 26, 1998:

<TABLE>
                                                              For the Year Ended December 26, 1998
                                               -----------------------------------------------------------------
                                               Tektagen     Therion       ESD       Adjustments         Total
                                               --------     -------   -----------   -----------       ----------
<S>                                              <C>          <C>       <C>           <C>              <C>
Net sales....................................    $ 917        $310      $2,230        $    --          $ 3,457
Cost of products sold and services
   provided..................................      977          89       1,650             --            2,716
   Selling, general and administrative
     expenses................................      407          85         313             --              805
   Amortization of goodwill and other
   intangibles...............................       --          --          --            116(e)           116(e)
                                                 -----       -----      ------        -------         --------
Operating income.............................     (467)        136         267           (116)            (180)
Interest income..............................       --          --          --             --               --
Interest expense.............................      (23)         --          --             --              (23)
(Loss) gain from foreign currency, net.......       --          --          --             --               --
                                                 -----       -----      ------        -------         --------
(Loss) income before income taxes,
   minority interests and earnings from
   equity investments.....................        (490)        136         267           (116)            (203)
   Provision (benefit) for income taxes...          --          43         107             --              150
                                                 -----       -----      ------        -------         --------
(Loss) income before minority interests
   and earnings from equity investments...        (490)         93         160           (116)            (353)
   Minority interests.....................          --          --          --             --               --
                                                 -----       -----      ------        -------         --------
Earnings from equity investments.............       --           2          --             --                2
                                                 -----       -----      ------        -------         --------
Net (loss) income............................    $(490)      $  95      $  160        $  (116)        $   (351)
                                                 =====       =====      ======        =======         ========
</TABLE>


                                      P-11


<PAGE>



<TABLE>

                                                          For the Nine Months Ended September 26, 1998
                                               -----------------------------------------------------------------
                                               Tektagen     Therion       ESD       Adjustments         Total
                                               --------     -------   -----------   -----------       ----------
<S>                                             <C>         <C>         <C>          <C>              <C>
Net sales....................................  $ 917        $310        $1,757       $     --          $ 2,984
Cost of products sold and services
   provided..................................    977          89         1,370             --            2,436
Selling, general and administrative
   expenses..................................    407          85           231             --              723
Amortization of goodwill and other
   intangibles...............................     --          --            --            116(e)           116(e)
                                               -----        ----        ------       --------          -------
Operating income.............................   (467)        136           156           (116)            (291)
Interest income..............................     --          --            --             --               --
Interest expense.............................    (23)         --            --             --              (23)
Loss from foreign currency, net..............     --          --            --             --               --
                                                ----       -----         -----       --------          -------
(Loss) income before income taxes,
   minority interests and earnings from
   equity investments.......................    (490)        136           156          (116)             (314)
Provision (benefit) for income taxes........      --          43            62            --               105
                                                ----       -----         -----       -------           -------
(Loss) income before minority interests
   and earnings from equity investments.....    (490)         93            94          (116)             (419)
Earnings from equity investments............      --           2            --            --                 2
Minority interests..........................      --          --            --            --                --
                                               -----       -----         -----       -------           -------
Net (loss) income...........................   $(490)      $  95         $  94       $  (116)          $  (417)
                                               =====       =====         =====       =======           =======
</TABLE>

(c)   Represents the historical unaudited consolidated financial results of
      Sierra. The results also reflect related pro forma adjustments to goodwill
      amortization, interest and tax expense.

      As part of the Sierra Acquisition, the Company has agreed to pay up to
      $10,000 in performance-based bonus payments if certain financial
      objectives are reached over the next five years. At the time these
      contingencies are resolved, the bonuses, if any, will be recorded as
      compensation expense. As these amounts are not reasonably estimable, the
      expense related to those bonus payments has not been included in the pro
      forma financial statements.

      Also in conjunction with the Sierra Acquisition, the Company will enter
      into employment agreements with certain Sierra employees that contain
      retention and non-competition payments totaling $3,000 to be paid upon
      their continuing employment with the Company at December 31, 1999 and June
      30, 2001. The expense related to these payments has not been included in
      the pro forma financial statements as they are considered non-recurring.
      At the time these contingencies are resolved, the payments, if any, will
      be recorded as compensation expense.

(d)   The Company does not expect the estimated stand alone costs to be
      significantly different from the historical costs allocated by B&L due to
      the autonomy with which the Company operated.

(e)   Reflects the incremental expense required to reflect amortization of
      goodwill generated in the 1998 Acquisitions and the identifiable
      intangibles and goodwill acquired in connection with the Sierra
      Acquisition based on estimated useful lives ranging from 5-15 years.

(f)   Reflects the reduction of historical interest income for the respective
      period based upon the pro forma cash balance resulting from the
      Transactions and an assumed interest rate of 5%.

(g)   Reflects the adjustment to unaudited pro forma consolidated interest
      expense as a result of the Transactions:


                                      P-12


<PAGE>


<TABLE>


                                                                 Nine Months    Nine Months
                                                    Year Ended      Ended          Ended
                                                   December 26,  September 26,  September 25,
                                                       1998          1998          1999
                                                   ------------  -------------  -------------
<S>                                                    <C>          <C>            <C>
Increase in interest expense

   Notes offered hereby(1)......................   $    20,203    $    15,152    $    17,222
   Term loans(2)................................        14,500         10,875         10,875
   Revolver(3)..................................           310            233            233
   Amortization of deferred financing costs(4)..         1,523          1,142          1,142
                                                   -----------    -----------    -----------
      Total(5)..................................   $    36,536    $    27,402    $    29,472
                                                   ===========    ===========    ===========

</TABLE>
- -------------------
     (1)  Interest expense was calculated at an effective interest rate of
          13.66%.

     (2)  Interest expense was calculated at an effective blended interest rate
          of 9.06%, which is based upon a base rate or LIBOR plus a margin and
          is reset every six months.

     (3)  Represents interest expense calculated at 8.50% plus fees on the
          unused portion of 0.50%.

     (4)  Represents annual amortization expense utilizing a weighted average
          maturity on all borrowings of 8.70 years.


                                     P-13


<PAGE>



     (5)  A 0.125% increase or decrease in the effective weighted average
          interest rate for the senior credit facilities would change pro forma
          interest expense by $203, $152 and $152 for the fiscal year ended
          December 26, 1998 and the nine months ended September 26, 1998 and
          September 25, 1999, respectively.

(h)  To eliminate Sierra's historical interest expense related to debt that,
     according to the terms of the Sierra stock purchase agreement, will be
     repaid.

(i)  Represents the income tax adjustment required to result in a pro forma
     income tax provision based on: (i) Charles River's historical tax provision
     using historical amounts and (ii) the direct tax effects of the pro forma
     adjustments described above.

(j)  Represents the income tax adjustment required to result in a pro forma
     income tax provision based on: (i) Sierra's historical tax provision using
     historical amounts and (ii) the direct tax effects of the pro forma
     adjustments described above.

                                      P-14


<PAGE>



                   INDEX TO CONSOLIDATED FINANCIAL STATEMENTS


                                                                            Page
                                                                            ----

Charles River Laboratories, Inc.

Report of Independent Accountants.......................................... F-2

Consolidated Statements of Income for the years ended December 28, 1996,
   December 27, 1997 and December 26, 1998................................. F-3

Consolidated Balance Sheets as of December 27, 1997 and December 26, 1998.. F-4

Consolidated Statement of Cash Flows for the years ended December 28, 1996,
   December 27, 1997 and December 26, 1998 ................................ F-5

Consolidated Statement of Changes in Shareholder's Equity for the years
   ended December 30, 1995, December 28, 1996, December 27, 1997 and
   December 26, 1998....................................................... F-7

Notes to Consolidated Financial Statements................................. F-8

Consolidated Statements of Income for the nine months ended September 26,
   1998 and September 25, 1999 (unaudited)................................. F-24

Consolidated Balance Sheet as of September 25, 1999 (unaudited)............ F-25

Consolidated Statements of Cash Flows for the nine months ended
   September 26, 1998 and September 25, 1999 (unaudited)................... F-26

Notes to Interim Consolidated Financial Statements (unaudited)............. F-28

                                       F-1

<PAGE>

                        Report of Independent Accountants


To the Board of Directors of
Charles River Laboratories, Inc.


     In our opinion, the accompanying consolidated balance sheets and the
related consolidated statements of income, changes in shareholder's equity and
cash flows present fairly, in all material respects, the financial position of
Charles River Laboratories, Inc. and its subsidiaries (the "Company") at
December 26, 1998 and December 27, 1997, and the results of their operations and
their cash flows for each of the three years in the period ended December 26,
1998, in conformity with generally accepted accounting principles. In addition,
in our opinion, the financial statement schedule listed in the index appearing
under Item 16(b) presents fairly, in all material respects, the information set
forth therein when read in conjunction with the related consolidated financial
statements. These financial statements and the financial statement schedule are
the responsibility of the Company's management; our responsibility is to express
an opinion on these financial statements and the financial statement schedule
based on our audits. We conducted our audits of these statements in accordance
with generally accepted auditing standards which require that we plan and
perform the audit to obtain reasonable assurance about whether the financial
statements are free of material misstatement. An audit includes examining, on a
test basis, evidence supporting the amounts and disclosures in the financial
statements, assessing the accounting principles used and significant estimates
made by management, and evaluating the overall financial statement presentation.
We believe that our audits provide a reasonable basis for the opinion expressed
above.


PricewaterhouseCoopers LLP
Boston, Massachusetts

June 30, 1999,
except as to Note 2, which is as of September 29, 1999

                                       F-2

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
                        CONSOLIDATED STATEMENTS OF INCOME
                             (dollars in thousands)

<TABLE>

                                                                                   Fiscal Year Ended
                                                                        --------------------------------------
                                                                        December 28, December 27, December 26,
                                                                            1996         1997         1998
                                                                        ------------ ------------ ------------
<S>                                                                     <C>          <C>          <C>
Net sales related to products...........................................  $146,477     $156,800     $163,377
Net sales related to services...........................................     9,127       13,913       23,924
                                                                          --------     --------     --------
Total net sales.........................................................   155,604       170,713     193,301
Costs and expenses
   Cost of products sold................................................    91,600      102,980      107,146
   Cost of services provided............................................     6,177        8,480       15,401
   Selling, general and administrative..................................    28,327       30,451       34,142
   Amortization of goodwill and intangibles.............................       610          834        1,287
   Restructuring charges................................................     4,748        5,892           --
                                                                           -------      -------      -------
Operating income........................................................    24,142       22,076       35,325
Other income (expense)
   Interest income......................................................       654          865          986
   Interest expense.....................................................      (491)        (501)        (421)
   Gain/(loss) from foreign currency, net...............................        84         (221)         (58)
                                                                           -------      -------      -------
Income before income taxes, minority interests and earnings
   from equity investments..............................................    24,389       22,219       35,832
Provision for income taxes..............................................    10,889        8,499       14,123
                                                                           -------      -------      -------
Income before minority interests and earnings from equity investments...    13,500       13,720       21,709
Minority interests......................................................        (5)         (10)         (10)
Earnings from equity investment.........................................     1,750        1,630        1,679
                                                                           -------      -------      -------
Net income..............................................................   $15,245      $15,340      $23,378
                                                                           =======      =======      =======
</TABLE>

                 See Notes to Consolidated Financial Statements.

                                       F-3

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
                           CONSOLIDATED BALANCE SHEETS
                             (dollars in thousands)

<TABLE>
                                                                               December 27, December 26,
                                                                                   1997         1998
                                                                               ------------ ------------
Assets
   Current assets
<S>                                                                            <C>          <C>
      Cash and cash equivalents................................................   $17,915      $24,811
      Trade receivables, less allowances of $688 and $898, respectively........    28,280       32,466
      Inventories..............................................................    28,904       30,731
      Deferred income taxes....................................................     4,751        5,432
      Due from affiliates......................................................     1,153          982
      Other current assets.....................................................     2,320        2,792
                                                                                  -------      -------
        Total current assets...................................................    83,323       97,214
   Property, plant and equipment, net..........................................    76,889       82,690
   Goodwill and other intangibles, less accumulated amortization of $4,356
      and $5,591 respectively..................................................     8,621       17,705
   Investments in affiliates...................................................    16,140       18,470
   Other assets................................................................    11,238       17,331
                                                                                  -------      -------
        Total assets...........................................................  $196,211     $233,410
                                                                                  =======      =======

Liabilities and Shareholder's Equity
   Current liabilities
      Current portion of long-term debt........................................       $83         $202
      Current portion of capital lease obligations.............................       144          188
      Accounts payable.........................................................     7,566       11,615
      Accrued compensation.....................................................     8,601        9,972
      Accrued ESLIRP...........................................................     4,407        5,160
      Deferred income..........................................................     1,339        3,419
      Accrued restructuring....................................................     2,732        1,113
      Accrued liabilities......................................................     8,282       13,794
      Accrued income taxes.....................................................     8,423       14,329
                                                                                  -------      -------
        Total current liabilities..............................................    41,577       59,792
   Long-term debt..............................................................       170          248
   Capital lease obligations...................................................       966          944
   Other long-term liabilities.................................................     3,844        3,861
                                                                                  -------      -------
        Total liabilities......................................................    46,557       64,845
                                                                                  -------      -------
   Commitments and contingencies (Note 12)
   Minority interests..........................................................       290          306
   Shareholder's equity
      Common stock, par value $1 per share, 1,000 shares issued................         1            1
      Capital in excess of par value...........................................    17,836       17,836
      Retained earnings........................................................   140,320      156,776
      Accumulated other comprehensive income...................................    (8,793)      (6,354)
                                                                                  -------      -------
        Total shareholder's equity.............................................   149,364      168,259
                                                                                  -------      -------
        Total liabilities and shareholder's equity.............................  $196,211     $233,410
                                                                                  =======      =======
</TABLE>


                 See Notes to Consolidated Financial Statements.

                                       F-4

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
                      CONSOLIDATED STATEMENTS OF CASH FLOWS
                             (dollars in thousands)

<TABLE>

                                                                                      Fiscal Year Ended
                                                                           --------------------------------------
                                                                           December 28, December 27, December 26,
                                                                               1996         1997         1998
                                                                           ------------ ------------ ------------
<S>                                                                        <C>          <C>          <C>

Cash flows relating to operating activities
   Net income..............................................................    $15,245      $15,340      $23,378
   Adjustments to reconcile net income to net cash provided by operating
      activities:
      Depreciation and amortization........................................      9,528        9,703       10,895
      Provision for doubtful accounts......................................         81          166          181
      Earnings from equity investments.....................................     (1,750)      (1,630)      (1,679)
      Minority interests...................................................          5           10           10
      Deferred income taxes................................................     (5,693)      (1,363)      (3,133)
      Stock compensation expense...........................................         24           84          333
      Property, plant and equipment write downs............................         --          822           --
   Changes in assets and liabilities

      Trade receivables....................................................     (1,840)      (2,232)      (1,712)
      Inventories..........................................................     (1,552)      (1,917)      (1,250)
      Due from affiliates..................................................       (845)        (462)         538
      Other current assets.................................................        133          165         (241)
      Other assets.........................................................     (1,787)         611       (4,990)
      Accounts payable.....................................................       (180)         594        2,853
      Accrued compensation.................................................       (347)         674        2,090
      Accrued ESLIRP.......................................................        674          499          821
      Deferred income......................................................        (62)         105        1,278
      Accrued restructuring................................................         --        2,732       (1,619)
      Accrued liabilities..................................................      1,705          431        3,970
      Accrued income taxes.................................................      6,852         (500)       5,605
     *Other long-term liabilities..........................................        354         (148)        (629)
                                                                                ------       ------       ------
       *Net cash provided by operating activities..........................     20,545       23,684       36,699
                                                                                ------       ------       ------
Cash flows relating to investing activities
   Dividends received from equity investments..............................        725          773          681
   Capital expenditures....................................................    (11,572)     (11,872)     (11,909)
  *Cash paid for acquisition of businesses.................................       (831)      (1,207)     (11,121)
                                                                                ------       ------       ------
       *Net cash used in investing activities..............................    (11,678)     (12,306)     (22,349)
                                                                                ------       ------       ------
Cash flows relating to financing activities
   Proceeds from long-term debt............................................         21          281          199
   Payment on long-term debt...............................................     (3,698)        (119)      (1,247)
   Payment on capital lease obligations....................................       (194)        (346)         (48)
  *Net activity with Bausch & Lomb.........................................       (197)     (12,755)      (6,922)
                                                                                 -----        -----        -----
  *     Net cash used in financing activities..............................     (4,068)    ( 12,939)      (8,018)
                                                                                 -----        -----        -----
*Effect of exchange rate changes on cash and cash equivalents..............       (478)        (181)         564
                                                                                 -----        -----        -----
Net change in cash and cash equivalents....................................      4,321       (1,742)       6,896
*Cash and cash equivalents, beginning of year..............................     15,336       19,657       17,915
                                                                                 -----        -----        -----


                 See Notes to Consolidated Financial Statements.

                                       F-5

<PAGE>


<CAPTION>

                                                                                      Fiscal Year Ended
                                                                           --------------------------------------
                                                                           December 28, December 27, December 26,
                                                                               1996         1997         1998
                                                                           ------------ ------------ ------------
<S>                                                                        <C>          <C>          <C>

**Cash and cash equivalents, end of year...................................    $19,657      $17,915      $24,811
                                                                                ======       ======       ======
Supplemental cash flow information
   Cash paid for taxes.....................................................     $4,821       $4,254       $4,681
   Cash paid for interest..................................................        414          287          177
</TABLE>

                 See Notes to Consolidated Financial Statements.

                                       F-6

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
           CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDER'S EQUITY
                             (dollars in thousands)

<TABLE>

                                                                               Accumulated
                                                                                  Other                  Capital
                                                                   Retained   Comprehensive    Common   In Excess
                                                         Total     Earnings       Income       Stock      of Par
                                                         -----     --------   -------------    ------   ---------
<S>                                                    <C>         <C>        <C>              <C>      <C>
Balance at December 30, 1995........................   $142,537    $122,687        $2,013       $  1      $17,836
   Components of comprehensive income:
      Net income....................................     15,245      15,245            --         --           --
      Foreign currency translation..................     (3,467)         --        (3,467)        --           --
      Minimum pension liability adjustment..........         15          --            15         --           --
                                                        -------
        Total comprehensive income..................     11,793
                                                        -------         --             --         --           --
   Net activity with Bausch & Lomb..................       (197)       (197)           --         --           --
                                                        -------     -------        ------      -----       ------
Balance at December 28, 1996........................   $154,133    $137,735       $(1,439)        $1      $17,836
   Components of comprehensive income:
      Net income....................................     15,340      15,340            --         --           --
      Foreign currency translation..................     (6,844)         --        (6,844)        --           --
      Minimum pension liability adjustment..........       (510)         --          (510)                     --
                                                        -------
        Total comprehensive income..................      7,986
                                                        -------          --            --         --           --
   Net activity with Bausch & Lomb..................    (12,755)    (12,755)           --         --           --
                                                        -------     -------        ------      -----       ------
Balance at December 27, 1997........................   $149,364    $140,320       $(8,793)        $1      $17,836
   Components of comprehensive income:
      Net income....................................     23,378      23,378            --         --           --
      Foreign currency translation..................      2,839          --         2,839         --           --
      Minimum pension liability adjustment..........       (400)         --          (400)                     --
                                                        -------
        Total comprehensive income..................     25,817
                                                        -------          --            --         --           --
   Net activity with Bausch & Lomb..................     (6,922)     (6,922)           --         --           --
                                                        -------     -------        ------      -----       ------
Balance at December 26, 1998........................   $168,259    $156,776       $(6,354)        $1      $17,836
                                                        =======     =======        ======      =====       ======
</TABLE>

                 See Notes to Consolidated Financial Statements.

                                       F-7

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                             (dollars in thousands)

1.   Description of Business and Summary of Significant Accounting Policies

   Description of Business

     Charles River Laboratories, Inc. (the "Company") is a commercial producer
and supplier of animal research models for use in the discovery, development and
testing of pharmaceuticals. In addition, the Company is a supplier of biomedical
products and services in several specialized niche markets. The Company is a
100% owned subsidiary of Bausch & Lomb Incorporated (Bausch & Lomb). The
Company's fiscal year is the twelve month period ending the last Saturday in
December.

   Basis of Presentation

     As of the dates and for the periods presented in these financial
statements, the assets, liabilities, operations and cash flows relating to the
Company are held by Bausch & Lomb and certain affiliated entities. As more fully
described in Note 2, effective September 29, 1999, the Company consummated a
recapitalization agreement that provides for the contribution of all such
assets, liabilities and operations to an existing dormant subsidiary which was
subsequently renamed CRL Holdings, Inc. These consolidated financial statements
include all such assets, liabilities, operations and cash flows as of and for
each of the periods presented.

   Principles of Consolidation

     The financial statements include all majority-owned U.S. and non-U.S.
subsidiaries. Intercompany accounts, transactions and profits are eliminated.
Affiliated companies over which the Company does not have the ability to
exercise control are accounted for using the equity method (Note 11).

   Use of Estimates

     The financial statements have been prepared in conformity with generally
accepted accounting principles and, as such, include amounts based on informed
estimates and judgments of management with consideration given to materiality.
Actual results could differ from those estimates.

   Cash and Cash Equivalents

     Cash equivalents include time deposits and highly liquid investments with
remaining maturities at the purchase date of three months or less.

   Inventories

     Inventories are stated at the lower of cost or market. Cost is determined
principally on the average cost method. All inventories have been reduced to
their net realizable value. Costs for primates are accumulated in inventory
until certain primates are sold or declared breeders.

   Property, Plant and Equipment

     Property, plant and equipment, including improvements that significantly
add to productive capacity or extend useful life, are recorded at cost, while
maintenance and repairs are expensed as incurred. Depreciation is calculated for
financial reporting purposes using the straight-line method based on the
estimated useful lives of the assets as follows: building, 20 to 40 years;
machinery and equipment, 2 to 20 years; and leasehold improvements, shorter of
estimated useful life or the lease periods.

                                       F-8

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (Continued)
                             (dollars in thousands)


   Intangible Assets

     Intangible assets are amortized on a straight-line basis over periods
ranging from eight to 20 years. Intangible assets consist primarily of goodwill,
patents and non-compete agreements.

   Other Assets

     Other assets consist primarily of the cash surrender value of life
insurance net long-term deferred tax assets and the net value of primate
breeders. The value of primate breeders is amortized over 20 years. Total
amortization expense for primate breeders was $378, $348 and $323 in 1996, 1997
and 1998 and is included in costs of products sold and services provided.

   Impairment of Long-Lived Assets

     The Company evaluates long-lived assets and intangibles whenever events or
changes in circumstances indicate that the carrying amount of an asset may not
be recoverable. An impairment loss would be recognized when estimated
undiscounted future cash flows expected to result from the use of the asset and
its eventual disposal are less than its carrying amount. In such instances, the
carrying value of long-lived assets is reduced to the estimated fair value, as
determined using an appraisal or discounted cash flow, as appropriate.

   Stock-Based Compensation Plans

     As permitted under Statement of Financial Accounting Standards No. 123,
"Accounting for Stock-Based Compensation" (FAS 123), the Company accounts for
its stock-based compensation plans using the intrinsic value method prescribed
by Accounting Principles Board Opinion No. 25, "Accounting for Stock Issued to
Employees" (APB 25).

   Revenue Recognition


     Revenues are recognized when products are shipped or as services are
performed. Deferred income represents cash received in advance of delivery of
primates from customers under contract and is recognized at time of delivery.


   Fair Value of Financial Instruments

     The carrying amount of the Company's significant financial instruments,
which includes accounts receivable and debt, approximate their fair values at
December 26, 1998 and December 27, 1997.

   Income Taxes

     As of December 26, 1998, the Company was not a separate taxable entity for
federal, state or local income tax purposes and its results of operations were
included in the consolidated Bausch & Lomb tax returns. The Company accounts for
income taxes under the separate return method in accordance with Statement of
Financial Accounting Standards No. 109, "Accounting for Income Taxes" (FAS 109).

   Foreign Operations

                                       F-9

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (Continued)
                             (dollars in thousands)


     The financial statements of all non-U.S. subsidiaries are translated into
U.S. dollars as follows: assets and liabilities at year-end exchange rates;
income, expenses and cash flows at average exchange rates; and shareholder's
equity at historical exchange rates. The resulting translation adjustment is
recorded as a component of accumulated other comprehensive income on the
accompanying balance sheet.

   Concentrations of Credit Risk

     Financial instruments that potentially subject the Company to
concentrations of credit risk consist primarily of trade receivables from
customers within the pharmaceutical and biomedical industries. As these
industries have experienced significant growth and its customers are
predominantly well-established and viable, the Company believes its exposure to
credit risk to be minimal.

   Comprehensive Income

     The Company adopted Statement of Financial Accounting Standards No. 130,
"Reporting Comprehensive Income," (FAS 130) at the beginning of 1998. As it
relates to the Company, comprehensive income is defined as net income plus the
sum of currency translation adjustments and the change in minimum pension
liability (collectively, other comprehensive income), and is presented in the
Consolidated Statement of Changes in Shareholder's Equity.

   Segment Reporting

     During 1998, the Company adopted Statement of Financial Accounting
Standards No. 131, "Disclosures About Segments of an Enterprise and Related
Information" (FAS 131), which requires financial and descriptive information
about an enterprise's reportable operating segments. Operating segments are
components of an enterprise about which separate financial information is
available and regularly evaluated by the chief operating decision maker in
deciding how to allocate resources and in assessing performance. The Company
operates in two business segments, research models and biomedical products and
services.

   Reclassifications

     Certain amounts in prior year financial statements and related notes have
been changed to conform with current year presentation.

2.   Subsequent Events

     On September 29, 1999 CRL Acquisition LLC, an affiliate of DLJ Merchant
Banking Partners II, L.P., consummated a transaction in which it acquired 87.5%
of the common stock of Charles River Laboratories, Inc. from Bausch & Lomb for
approximately $443 million. This transaction was effected through Charles River
Laboratories Holdings, Inc. ("Holdings"), a holding company with no operations
or assets other than its ownership of 100% of the Company's outstanding stock.
This transaction will be accounted for as a leveraged recapitalization, which
will have no impact on the historical basis of the Company's assets and
liabilities. In addition, concurrent with the transaction, the Company purchased
all of the outstanding shares of common stock of SBI Holdings, Inc. ("Sierra"),
a pre-clinical biomedical services company, for $24.0 million. This acquisition
will be accounted for as a purchase business combination with the operating
results of Sierra being included in the Company's consolidated operating results
beginning on the effective date of the acquisition. These transactions are
hereafter referred to as the "Acquisitions".

     The Acquisitions and related transaction fees and expenses were funded as
follows:

                                      F-10

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (Continued)
                             (dollars in thousands)



      o  issuance of 150,000 units, each consisting of a $1,000 principal amount
         of 13.5% senior subordinated note (the Series A Note Offering) and one
         warrant to purchase 3.942 shares of common stock of Holdings;

      o  borrowings by the Company of $162.0 million under a new senior secured
         credit facility;

      o  an equity investment of $92.4 million in Holdings;

      o  senior discount debentures with warrants issued by Holdings for $37.6
         million; and

      o  subordinated discount note issued by Holdings to Bausch & Lomb for
         $43.0 million.

     The Series A Note Offering (the "Notes") will mature on October 1, 2009.
The Notes will not be redeemable at the issuers' option prior to October 1,
2004. Thereafter, the Notes will be subject to redemption at any time at the
option of the issuer at redemption prices set forth in the Notes. Interest on
the Notes will accrue at the rate of 13.5% per annum and will be payable
semi-annually in arrears on October 1 and April 1 of each year, commencing on
April 1, 2000. The payment of principal and interest on the Notes will be
subordinated in right to the prior payment of all Senior Debt, as defined. The
senior secured credit facility includes a $40 million term loan A facility, a
$120 million term loan B facility and a $30 million revolving credit facility.
The term loan A facility will mature on October 1, 2005, the term loan B
facility will mature on October 1, 2007 and the revolving credit facility will
mature on October 1, 2005. Interest on the term loan A, term loan B and
revolving credit facility will accrue at either a base rate plus 1.75% or LIBOR
plus 3.0%, at the Company's option (8.5%, 9.25% and 8.5%, respectively, at
September 29, 1999) per annum and will be paid quarterly in arrears commencing
on December 30, 1999. A commitment fee in an amount equal to 0.50% per annum on
the daily average unused portion of the revolving credit facility will be paid
quarterly in arrears. Upon the occurrence of a change in control, as defined,
the issuer will be obligated to make an offer to each holder of the Notes to
repurchase all or any part of such holders' Notes at an offer price in cash
equal to 101% of the principal amount thereof, plus accrued and unpaid interest.
Restrictions under the Notes include certain sales of assets, certain payments
of dividends and incurrence of debt, and limitations on certain mergers and
transactions with affiliates. With respect to the Notes and the senior secured
credit facility, the Company will be required to maintain certain financial
ratios and covenants.

3.   Restructuring Charges and Asset Impairments

     In June 1996 and April 1997, the Bausch & Lomb board of directors approved
plans to restructure portions of the Company. As a result, pre-tax restructuring
charges of $4,748 and $5,892 were recorded in 1996 and 1997, respectively. The
major components of the plans are summarized in the table below:

                                                          1996       1997
                                                         ------     ------
Employee separations..................................   $2,283     $3,200
Asset writedowns......................................    1,631      2,157
Other.................................................      834        535
                                                          -----      -----
                                                         $4,748     $5,892
                                                          =====      =====



     The overall purpose of the restructuring charges was to reduce costs and
improve profitability by closing excess capacity and eliminating associated
personnel, reducing excess corporate, administrative and professional personnel,
and exiting several small unprofitable product-lines. The restructuring actions
affected both the research model and biomedical products and services segments.
In total over 70 individuals were terminated in connection with these actions.


     These restructuring efforts have reduced the Company's fixed cost structure
and realigned the business to meet its strategic objectives through the closure,
relocation and consolidation of breeding, distribution, sales and administrative
operations, and workforce reductions. Certain severance costs are being paid
over periods greater than one year. Further, the Company is under a court order
issued in June 1997 to relocate a portion of its primate operations from two

                                      F-11

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (Continued)
                             (dollars in thousands)


islands located in the Florida Keys to Miami, Florida. Also, the Company is
required to refoliate the islands due to damage caused by the primates. Due to
complications arising within the plan to relocate the primates, the relocation
has taken longer than anticipated to complete, as the primates needed to be
moved in a controlled manner in order to minimize mortality and breeding
disruption. Asset writedowns relate primarily to the closing of facilities and
losses resulting from equipment dispositions. Other charges included
miscellaneous costs and other commitments.

     The following table sets forth the activity in the restructuring reserves
through December 26, 1998:
                                                      Restructuring Programs
                                                   ----------------------------
                                                   1996       1997        Total
                                                   ----       ----        -----
Restructuring provision........................   $4,748         --      $4,748
Cash payments..................................   (3,117)        --      (3,117)
Asset write-downs..............................   (1,631)        --      (1,631)
                                                   -----      -----       -----
   Balance, December 28, 1996..................       --         --          --
Restructuring provision........................       --      5,892       5,892
Cash payments .................................       --     (1,725)     (1,725)
Asset write-downs..............................       --     (1,435)     (1,435)
                                                   -----      -----       -----
   Balance, December 27, 1997..................       --      2,732       2,732
Cash payments..................................       --       (897)       (897)
Asset write-downs..............................       --       (722)       (722)
                                                   -----      -----       -----
   Balance, December 26, 1998..................   $   --     $1,113      $1,113
                                                   =====      =====       =====


     Reserves remaining at December 26, 1998 primarily represent liabilities for
continuing severance payments and relocation and refoliation costs. The
remaining balance of $1,113 is expected to be fully utilized by the end of 1999.

4.   Supplemental Balance Sheet Information

     The composition of inventories is as follows:


                                                      December 27,  December 26,
                                                          1997          1998
                                                      ------------  ------------
Raw materials and supplies...........................    $ 5,222      $ 4,932
Work in process......................................        379        1,088
Finished products....................................     23,303       24,711
                                                           -----        -----
   Inventories.......................................    $28,904      $30,731
                                                           =====        =====


                                      F-12

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (Continued)
                             (dollars in thousands)


     The composition of property, plant and equipment is as follows:


                                                      December 27,  December 26,
                                                          1997          1998
                                                      ------------  ------------
Land.................................................    $ 7,473     $  7,783
Buildings............................................     82,963       90,919
Machinery and equipment..............................     63,192       74,876
Leasehold improvements...............................      1,033        3,063
Furniture and fixtures...............................      1,383        1,532
Vehicles.............................................      2,864        3,006
Construction in progress.............................      8,483        6,176
                                                         -------      -------
                                                         167,391      187,355
Less accumulated depreciation........................    (90,502)    (104,665)
                                                         -------      -------
   Net property, plant and equipment.................   $ 76,889     $ 82,690
                                                         =======      =======


5.   Long-Term Debt

     The Company has various debt instruments outstanding at its international
subsidiaries aggregating $253 and $450 at December 27, 1997 and December 26,
1998, respectively, with interest rates ranging from 3% to 15.2% and maturities
ranging from September 1999 through June 2003.

6.   Leases

   Capital Leases

     The Company has one capital lease for a building and three capital leases
for equipment. These leases are capitalized using interest rates considered
appropriate at the inception of each lease. Following is an analysis of assets
under capital lease:


                                                      December 27,  December 26,
                                                          1997          1998
                                                      ------------  ------------
Building.............................................     $2,001       $2,001
Equipment............................................        179          179
Accumulated depreciation.............................     (1,213)      (1,457)
                                                           -----        -----
                                                          $  967       $  723
                                                           =====        =====


                                      F-13

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (Continued)
                             (dollars in thousands)


     Capital lease obligations amounted to $1,110 and $1,132 at December 27,
1997 and December 26, 1998, respectively, with maturities through 2003 at
interest rates ranging from 8.6% to 9.3%. Future minimum lease payments under
capital lease obligations at December 26, 1998 are as follows:

          1999.........................................................$  282
          2000.........................................................   282
          2001.........................................................   282
          2002.........................................................   282
          2003.........................................................   534
                                                                        -----
          Total minimum lease payments................................. 1,662
          Less amount representing interest............................  (530)
                                                                        -----
          Present value of net minimum lease payments..................$1,132
                                                                        =====

     Operating Leases

     The Company has various operating leases for machinery and equipment,
automobiles, office equipment, land and office space. Rent expense for all
operating leases was $2,944 in 1996, $3,111 in 1997 and $3,273 in 1998. Future
minimum payments by year and in the aggregate, under noncancellable operating
leases with initial or remaining terms of one year or more consist of the
following at December 26, 1998:

          1999.........................................................$3,182
          2000......................................................... 2,932
          2001......................................................... 1,994
          2002......................................................... 1,088
          2003.........................................................   488
          Thereafter................................................... 1,690
                                                                       ------
                                                                      $11,374
                                                                       ======

7.   Income Taxes

     An analysis of the components of income before income taxes and minority
interests and the related provision for income taxes is presented below:

     <TABLE>

                                                                         Fiscal Year Ended
                                                               --------------------------------------
                                                               December 28, December 27, December 26,
                                                                   1996         1997         1998
                                                               ------------ ------------ ------------
<S>                                                            <C>          <C>          <C>
Income before equity in earnings of foreign subsidiaries,
   income taxes and minority interests
   U.S........................................................    $15,422      $13,497      $22,364
   Non-U.S....................................................      8,967        8,722       13,468
                                                                   ------       ------       ------
                                                                  $24,389      $22,219      $35,832
                                                                   ======       ======       ======

                                      F-14

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (Continued)
                             (dollars in thousands)

<CAPTION>

                                                                         Fiscal Year Ended
                                                               --------------------------------------
                                                               December 28, December 27, December 26,
                                                                   1996         1997         1998
                                                               ------------ ------------ ------------
<S>                                                            <C>          <C>          <C>
Income tax provision
   Current:
      Federal.................................................    $ 5,506      $ 6,202      $ 7,730
      Foreign.................................................      4,217        2,528        6,171
      State and local.........................................      1,406        1,397        1,833
                                                                   ------       ------       ------
        Total current.........................................     11,129       10,127       15,734
                                                                   ------       ------       ------
   Deferred:
      Federal.................................................       (496)      (1,867)        (597)
      Foreign.................................................        376          498         (887)
      State...................................................       (120)        (259)        (127)
                                                                   ------       ------       ------
        Total deferred........................................       (240)      (1,628)      (1,611)
                                                                   ------       ------       ------
                                                                  $10,889       $8,499      $14,123
                                                                   ======       ======       ======
</TABLE>

     Deferred taxes, detailed below, recognize the impact of temporary
differences between the amounts of assets and liabilities recorded for financial
statement purposes and such amounts measured in accordance with tax laws.
Realization of benefit for net operating losses and foreign tax credit
carryforwards, which expire between 2002 and 2011, is contingent on future
taxable earnings. A valuation allowance has been recorded for foreign tax
credits, which may not be realized.

<TABLE>
                                                             December 27, 1997       December 26, 1998
                                                            --------------------    --------------------
                                                            Assets   Liabilities    Assets   Liabilities
                                                            ------   -----------    ------   -----------
<S>                                                         <C>      <C>            <C>      <C>
Current:
   Inventories...........................................   $  588          --      $  827          --
   Restructuring accruals................................    1,584          --       1,006          --
   Employee benefits and compensation....................    2,023          --       3,077          --
   Other accruals........................................      556          --         522          --
                                                             -----       -----      ------       -----
                                                             4,751          --       5,432          --
                                                             -----       -----      ------       -----

Non-current:
   Net operating loss and credit carryforwards...........    1,776                   2,960
   Depreciation and amortization.........................    3,326       1,723       3,672         836
   Valuation allowance on foreign tax credits............   (1,776)                 (1,766)
      Other..............................................      654          --         921          --
                                                             -----       -----      ------       -----
                                                             3,980       1,723       5,787         836
                                                             -----       -----      ======       =====
                                                            $8,731      $1,723     $11,219        $836
                                                             =====       =====      ======       =====
</TABLE>

     Reconciliations of the statutory U.S. federal income tax rate to effective
tax rates are as follows:


                                      F-15

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (Continued)
                             (dollars in thousands)


<TABLE>
                                                                      Fiscal Year Ended
                                                           ---------------------------------------
                                                           December 28, December 27,  December 26,
                                                               1996         1997          1998
                                                           ------------ ------------  ------------
<S>                                                        <C>          <C>           <C>
Tax at statutory U.S. tax rate.............................    35.0%        35.0%         35.0%
Foreign tax rate differences...............................     6.0         (0.1)          1.6
Non-deductible goodwill amortization.......................     0.3          0.4           0.6
State income taxes, net of federal tax benefit.............     3.4          3.3           3.1
Other......................................................    (0.6)        (0.4)         (0.8)
                                                               ----         ----          ----
                                                               44.1%        38.2%         39.5%
                                                               ====         ====          ====
</TABLE>


     The Company's foreign subsidiaries have undistributed earnings at December
26, 1998. Those earnings are considered to be indefinitely reinvested and,
accordingly, no provision for U.S. federal and state income taxes has been
provided thereon. Upon distribution of those earnings in the form of dividends
or otherwise, the Company would be subject to both U.S. income taxes (subject to
an adjustment for foreign tax credits) and withholding taxes payable to the
various foreign countries. Determination of the amount of unrecognized deferred
U.S. income tax liability is not practicable because of the complexities
associated with its hypothetical calculation.

8.   Employee Benefits

     The Company sponsors one defined contribution plan and two defined benefit
plans. The Company's defined contribution plan ("Charles River Laboratories
Employee Savings Plan") qualifies under section 401(k) of the Internal Revenue
Code. It covers substantially all U.S. employees and contains a provision
whereby the Company matches two percent of employee contributions up to four
percent. The costs associated with the defined contribution plan totaled $395,
$416 and $498 in 1996, 1997, and 1998, respectively.

     One of the Company-sponsored defined benefit plans (Charles River
Laboratories, Inc. Pension Plan) is a qualified, non-contributory plan that also
covers substantially all U.S. employees. Benefits are based on participants'
final average monthly compensation and years of service. Participants' rights
vest upon completion of five years of service.

     Under another defined benefit plan, the Company provides certain executives
with supplemental retirement benefits. This plan (Executive Supplemental Life
Insurance Retirement Plan or ESLIRP) is generally unfunded and non-qualified
under the provisions of the Employee Retirement Income Securities Act of 1974.

     The following table provides reconciliations of the changes in benefit
obligations, fair value of plan assets and funded status of the two defined
benefit plans.

<TABLE>

                                                                    Pension Benefit Plans
                                                                    ---------------------
                                                                     1997           1998
                                                                    ------         ------
<S>                                                                 <C>            <C>
Reconciliation of benefit obligation
   Benefit/obligation at beginning of year........................  $17,570        $20,531
   Service cost...................................................      804            795
   Interest cost..................................................    1,413          1,588
   Benefit payments...............................................     (710)          (742)
   Actuarial loss.................................................    1,454          2,940
                                                                     ------         ------
   Benefit/obligation at end of year..............................  $20,531        $25,112
                                                                     ======         ======
Reconciliation of fair value of plan assets


                                      F-16

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (Continued)
                             (dollars in thousands)
<CAPTION>

                                                                   Pension Benefit Plans
                                                                    ---------------------
                                                                     1997           1998
                                                                    ------         ------
<S>                                                                 <C>            <C>
   Fair value of plan assets at beginning of year.................  $17,394        $19,237
   Actual return on plan assets...................................    2,328          7,773
   Employer contributions.........................................      225            225
   Benefit payments...............................................     (710)          (742)
                                                                     ------         ------
   Fair value of plan assets at end of year.......................  $19,237        $26,493
                                                                     ======         ======
Funded status
   Funded status at beginning of year.............................  $(1,294)       $ 1,380
   Unrecognized transition obligation.............................      705            564
   Unrecognized prior-service cost................................      (31)           (27)
   Unrecognized gain..............................................   (4,331)        (7,178)
                                                                     ------         ------
   Accrued benefit (cost).........................................  $(4,951)       $(5,261)
                                                                     ======         ======
Amounts recognized in the consolidated balance sheet
   Accrued benefit cost...........................................  $(6,945)       $(7,849)
   Intangible asset...............................................      358            286
   Accumulated other comprehensive income.........................      982          1,381
                                                                     ------         ------
   Net amount recognized..........................................  $(5,605)       $(6,182)
                                                                     ======         ======
</TABLE>

     Key weighted-average assumptions used in the measurement of the Company's
benefit obligations are shown in the following table:


                                                   Fiscal Year Ended
                                        ---------------------------------------
                                        December 28, December 27,  December 26,
                                            1996         1997          1998
                                        ------------ ------------  ------------
Discount rate...........................    7.75%         7.5%            7%
Expected return on plan assets..........      10%          10%           10%
Rate of compensation increase...........     5.0%        4.75%         4.75%


          The following table provides the components of net periodic benefit
cost for the two defined benefit plans for 1996, 1997 and 1998:


                                                       Defined Benefit Plans
                                                    ---------------------------
                                                     1996      1997       1998
                                                    ------    ------     ------
Components of net periodic benefit cost
Service cost......................................  $  690     $  804    $  795
Interest cost.....................................   1,236      1,413     1,588
Expected return on plan assets....................  (1,463)    (1,717)   (1,901)
Amortization of transition obligation.............     141        141       141
Amortization of prior-service cost................      (3)        (3)       (3)
Amortization of net gain..........................    (189)      (172)      (85)
                                                     -----      -----     -----
Net periodic benefit cost.........................  $  412     $  466    $  535
                                                     =====      =====     =====

                                      F-17

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (Continued)
                             (dollars in thousands)


     The projected benefit obligation, accumulated benefit obligation, and fair
value of plan assets for the pension plan with accumulated benefit obligations
in excess of plan assets were $6,752, $6,409 and $0, respectively, as of
December 27, 1997, and $8,205, $7,745 and $0, respectively, as of December 26,
1998.

     The Company had an adjusted minimum pension liability of $1,636 ($982, net
of tax) and $2,302 ($1,381, net of tax) as of December 27, 1997 and December 26,
1998, which represented the excess of the minimum accumulated net benefit
obligation over previously recorded pension liabilities.

9.   Stock Compensation Plans

        Stock Options


    Bausch & Lomb sponsors several stock-based compensation plans in which the
Company's employees participate. Stock options vest ratably over three years and
expire ten years from the grant date. The exercise price on all options issued
has been equal to the fair market value of the underlying security on the date
of the grant. Vesting is contingent upon continued employment with Bausch &
Lomb. The total number of shares available for grant in each calendar year for
all plans combined excluding incentive stock options shall be no greater than
three percent of the total number of outstanding shares of common stock as of
the first day of each such year. No more than six million shares are available
for granting purposes as incentive stock options under Bausch & Lomb's current
plan. As of December 26, 1998, 2.5 million shares remain available for such
grants.


     All of Bausch & Lomb's stock-based compensation plans are accounted for
under the provisions of APB 25. Under APB 25, because the exercise price of the
Company's employee stock options equals the market price of the underlying stock
on the date of grant, no compensation expense is recognized.

     Pro forma information regarding net income is required by FAS 123, which
also requires that the information be determined as if the Company has accounted
for its employee stock options granted subsequent to December 31, 1994 under the
fair value method of that Statement.

     For purposes of this disclosure, the fair value of each fixed option grant
was estimated on the date of grant using the Black-Scholes option-pricing model
with the following weighted average assumptions used for grants outstanding in
1996, 1997 and 1998:

                                                   1996       1997       1998
                                                  ------     ------     ------
Risk-free interest rate..........................   6.11%      5.66%      4.69%
Dividend yield...................................   2.42%      2.54%      2.48%
Volatility factor................................  24.87%     25.17%     25.67%
Weighted average expected life (years)...........      5          5          4


     The Black-Scholes option valuation model was developed for use in
estimating the fair value of traded options which have no vesting restrictions
and are fully transferable. In addition, option valuation models require the
input of highly subjective assumptions including the expected stock price
volatility. Because Bausch & Lomb's employee stock options have characteristics
significantly different from those of traded options, and because changes in the
subjective input assumptions can materially affect the fair value estimate, in
management's opinion, the existing models do not necessarily provide a reliable
single measure of the fair value of its employee stock options.

     Had compensation expense for the Company's portion of fixed options been
determined consistent with FAS 123, the Company's net income would have been
reduced to the pro forma amounts indicated below:

                                      F-18

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (Continued)
                             (dollars in thousands)


                                        Net Income
                                --------------------------
                                As Reported      Pro Forma
                                -----------      ---------
1998......................        $23,378        $22,859
1997......................         15,340         15,021
1996......................         15,245         15,042


     A summary of the status of the Company's portion of fixed stock option
plans at year end 1996, 1997 and 1998 is presented below:


<TABLE>
                                                 1996                         1997                          1998
                                     --------------------------   --------------------------   ---------------------------
                                                    Weighted                     Weighted                      Weighted
                                                     Average                      Average                       Average
                                                 Exercise Price               Exercise Price                Exercise Price
                                      Shares       (Per Share)     Shares       (Per Share)      Shares       (Per Share)
                                     --------    --------------   --------    --------------    --------    --------------
<S>                                  <C>         <C>              <C>        <C>                <C>         <C>
Outstanding at beginning of year..   225,584         $40.84       294,162         $39.90        326,722          $41.00
Granted...........................    71,643          35.86        77,154          42.32         73,280           50.64
Exercised.........................       (80)         27.40       (13,350)         30.34        (73,481)          39.45
Forfeited.........................    (2,985)         43.60       (31,244)         41.99         (1,370)          41.48
                                     -------          -----       -------          -----        -------           -----
Outstanding at end of year........   294,162          39.90       326,722          41.00        325,151           43.98
                                     =======          =====       =======          =====        =======           =====
Options exercisable at year end...   177,155                      193,097                       176,096
                                     =======                      =======                       =======
Weighted-average fair value of
options granted during the year...   $  9.34                     $  10.59                      $  10.93
                                     =======                      =======                       =======
</TABLE>


     The following presents additional information about the Company's fixed
stock options outstanding at December 26, 1998:

<TABLE>
                                                 Options Outstanding                        Options Exercisable
                                      ----------------------------------------------    ------------------------------
                                                        Weighted
                                                        Average          Weighted
                                                       Remaining          Average                          Weighted
                                        Number        Contractual     Exercise Price      Number            Average
Range of Exercise Prices Per Share    Outstanding     Life (Years)      (Per Share)     Exercisable     Exercise Price
- ----------------------------------    -----------     ------------    --------------    -----------     --------------
<S>                                   <C>            <C>              <C>               <C>             <C>
$26 to $35........................        52,990            6.3            $34.78          39,726            $34.60
$36 to $45........................       131,413            7.3             41.35          81,577             40.88
$46 to $55........................       140,748            7.5             49.90          54,793             48.26
                                         -------                                          -------
$26 to $55........................       325,151            7.2             43.98         176,096             41.76
                                         =======                                          =======
</TABLE>


   Stock Awards

     Bausch & Lomb issued restricted stock awards to directors, officers and
other key personnel. These awards have vesting periods up to three years with
vesting criteria based upon the attainment of certain Economic-Value-Added (EVA)
metrics and continued employment until applicable vesting dates. EVA is a
measure of capital utilization. It is not, nor is it intended to be, a measure
of operating performance in accordance with generally accepted accounting
principles. Compensation expense is recorded based on the applicable vesting
criteria and, for those awards with performance goals, as such goals are met. In
1996, 1997 and 1998, 2,484, 1,400 and 1,200 such

                                      F-19

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (Continued)
                             (dollars in thousands)



awards were granted to Company employees at weighted average market values of
$35.92, $42.25 and $51.63 per share, respectively. The compensation expense
relating to stock awards in 1996, 1997 and 1998 was $24, $84 and $333,
respectively.

10. Business Acquisitions

     The Company acquired several businesses during the three-year period ended
December 26, 1998. All acquisitions have been accounted for under the purchase
method of accounting. The results of operations of the acquired business are
included in the consolidated financial statements from the date of acquisition.

     Significant acquisitions include the following:

     On March 30, 1998, the Company acquired 100% of the outstanding stock of
Tektagen, Inc. ("Tektagen") for $8,000 and assumed debt equal to approximately
$850. Tektagen provides quality control testing and consulting services to the
biotechnology and pharmaceutical industries. The purchase price exceeded the
fair value of the net assets acquired by approximately $6,600, which is being
amortized on a straight line basis over 15 years. In addition, during 1998 the
Company acquired an additional biomedical service business and one research
model business; the impact of each is considered immaterial to the Company's
financial statements taken as a whole.

     On July 31, 1996, the Company reacquired the assets of two businesses it
previously owned for approximately $1,100 in cash plus the forgiveness of
approximately $5,800 in debt. These businesses represent substantially all of
the Company's primate operations. The purchase price was allocated to the fair
value of net assets acquired.

     The following selected unaudited pro forma consolidated results of
operations are presented as if each of the acquisitions had occurred as of the
beginning of the period immediately preceding the period of acquisition after
giving effect to certain adjustments for the amortization of goodwill and
related income tax effects. The pro forma data is for informational purposes
only and does not necessarily reflect the results of operations had the
companies operated as one during the period. No effect has been given for
synergies, if any, that may have been realized through the acquisitions.


                                               Fiscal Year Ended
                                ------------------------------------------------
                                December 28,      December 27,      December 26,
                                    1996              1997              1998
                                ------------      ------------      ------------
(Amounts unaudited)
Net sales...................       $161,708          $179,513          $196,973
Operating income............         25,497            21,830            35,154
Net income..................         15,966            15,018            22,913


     In addition, during 1997 and 1998 the Company made contingent payments of
$640 and $681, respectively, to the former owner of an acquired business in
connection with an additional purchase price commitment.

11.  Joint Ventures

     The Company holds investments in several joint ventures. These joint
ventures are separate legal entities whose purpose is consistent with the
overall operations of the Company and represent geographical expansions of
existing Company markets. The financial results of two of the joint ventures are
consolidated into the Company's results as the Company has the ability to
exercise control over these entities. The interests of the outside joint venture
partners in these two joint ventures has been recorded as minority interests
totaling $290 at December 27, 1997 and $306 at December 26, 1998.

                                      F-20

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (Continued)
                             (dollars in thousands)


     The Company also has investments in two other joint ventures that are
accounted for on the equity method as the Company does not have the ability to
exercise control over the operations. Charles River Japan is a 50 /50 joint
venture with Ajinomoto Co., Inc. and is an extension of the Company's research
model business in Japan. Dividends received from Charles River Japan amounted to
$725 in 1996, $773 in 1997, and $681 in 1998. Charles River Mexico, a joint
venture which is an extension of the Company's avian business in Mexico, is not
significant to the Company's operations.

     Summarized financial statement information for the unconsolidated joint
ventures is as follows:

<TABLE>
                                                         Fiscal Year Ended
                                              ------------------------------------------
                                              December 28,   December 27,   December 26,
                                                  1996           1997           1998
                                              ------------   ------------   ------------
Condensed Combined Statements of Income
<S>                                           <C>            <C>            <C>
   Net sales................................     $43,978        $44,744        $39,798
   Operating income.........................       7,712          7,484          6,756
   Net income...............................       3,500          3,337          3,445
</TABLE>


                                                  December 27,      December 26,
                                                      1997              1998
                                                  ------------      ------------
Condensed Combined Balance Sheets
     Current assets.............................     $18,466           $19,388
     Non-current assets.........................      34,774            36,376
                                                      ------            ------
                                                     $53,240           $55,764
                                                      ======            ======
     Current liabilities........................     $17,105           $13,501
     Non-current liabilities....................       5,237             6,617
     Shareholders' equity.......................      30,898            35,646
                                                      ------            ------
                                                     $53,240           $55,764
                                                      ======            ======

12.  Commitments and Contingencies

   Insurance

     The Company maintains insurance for workers' compensation, auto liability
and general liability. The per claim loss limits are $250, with annual aggregate
loss limits of $1,500. Related accruals were $849 and $2,363 on December 27,
1997 and December 26, 1998, respectively. Separately, the Company has provided
three letters of credit in favor of the insurance carriers in the amount of
$825.

   Litigation

     Various lawsuits, claims and proceedings of a nature considered normal to
its business are pending against the Company. In the opinion of management, the
outcome of such proceedings and litigation currently pending will not materially
affect the Company's consolidated financial statements. The most potentially
significant claim is described below.

     As discussed in Note 3, the Company is currently under a court order
issued in June 1997 to remove its primate operations from two islands located in
the Florida Keys. The mandate asserts that the Company's operations have

                                      F-21

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (Continued)
                             (dollars in thousands)



contributed to the defoliation of certain protected plant life. Reserves of $500
are included in the restructuring reserve recorded in the accompanying
consolidated financial statements to provide for relocation costs and any
exposures in connection with the refoliation.

13. Related Party Transactions


     The Company historically has operated autonomously from Bausch & Lomb.
However, certain costs and expenses including insurance, information technology
and other miscellaneous expenses were charged to the Company on a direct basis.
Management believes these charges are based upon assumptions that are reasonable
under the circumstances. However, these charges and estimates are not
necessarily indicative of the costs and expenses which would have resulted had
the Company incurred these costs as a separate entity. Charges of approximately
$460, $470 and $250 for these items are included in costs of products sold and
services rendered and selling, general and administrative expense in the
accompanying consolidated statements of income for the years ended 1996, 1997
and 1998, respectively. The Company does not expect the estimated stand alone
costs to be significantly different from the historical costs allocated by B&L
due to the autonomy with which the Company operates.

     The accompanying financial statements include a line item "net activity
with Bausch and Lomb" which comprises the above referenced intercompany
allocations and the net distributions made by the Company to B&L.


14. Geographic and Business Segment Information

     The Company is organized into geographic regions for management reporting
with operating income being the primary measure of regional profitability.
Certain general and administrative expenses, including some centralized services
provided by regional offices, are allocated based on business segment sales. The
accounting policies used to generate geographic results are the same as the
Company's overall accounting policies.


     The following table presents sales and other financial information by
geography for the years 1996, 1997 and 1998. Included in the other non-U.S.
category below are the Company's operations located in Canada, China, Germany,
Italy, Netherlands, United Kingdom, Australia, Belgium, Czech Republic, Hungary,
Spain and Sweden. Sales to unaffiliated customers represent net sales
originating in entities physically located in the identified geographic area.
Long-lived assets include property, plant and equipment, goodwill and
intangibles, other investments and other assets.


<TABLE>
                                                                   Other
                                             U.S.      France     Non U.S.    Consolidated
                                           -------     ------     --------    ------------
<S>                                        <C>         <C>        <C>         <C>
1996
   Sales to unaffiliated customers.....   $ 83,520    $28,892      $43,192       $155,604
   Long-lived assets...................     65,594     12,790       18,952         96,336
1997
   Sales to unaffiliated customers.....   $100,314    $25,680      $44,719       $170,713
   Long-lived assets...................     62,236     10,146       22,108         94,490
1998
   Sales to unaffiliated customers.....   $115,639    $26,177      $51,485       $193,301
   Long-lived assets...................     76,289     12,751       23,745        112,785
</TABLE>

     The Company's product line segments are research models and biomedical
products and services. The following table presents sales and other financial
information by product line segment for the fiscal years 1996, 1997 and 1998.
Sales to unaffiliated customers represent net sales originating in entities
primarily engaged in either provision of research models or biomedical products
and services. Long-lived assets include property, plant and equipment, goodwill
and intangibles; other investments; and other assets.

                                      F-22

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (Continued)
                             (dollars in thousands)


                                        1996         1997         1998
Research models                        ------       ------       ------
     Net sales.....................  $ 121,262    $ 125,214    $ 134,590
     Operating income..............     24,080       19,583       30,517
     Total assets .................    162,201      157,915      180,139
     Depreciation and amortization       5,351        5,297        5,534
     Capital expenditures .........      6,119        6,178        8,127
Biomedical products and services
     Net sales ....................  $  34,342    $  45,499    $  58,711
     Operating income .............      3,264        6,496       11,117
     Total assets .................     34,780       38,296       53,271
     Depreciation and amortization.      4,177        4,406        5,361
     Capital expenditures .........      5,453        5,694        3,782



     A reconciliation of segment operating income to consolidated operating
income is as follows:

                                                Fiscal Year Ended
                                  --------------------------------------------
                                  December 28,    December 27,    December 26,
                                      1996            1997            1998
                                  ------------    ------------    ------------
Total segment operating income...    $27,344         $26,079         $41,634
Unallocated corporate overhead...     (3,202)         (4,003)         (6,309)
                                      ------          ------          ------
Consolidated operating income....    $24,142         $22,076         $35,325
                                      ======          ======          ======

     A summary of identifiable long-lived assets of each business segment at
year end is as follows:


                                          December 27,      December 26,
                                              1997              1998
                                          ------------      ------------
Research Models......................       $65,144          $ 73,190
Biomedical Products and Services.....        29,346            39,595
                                             ------           -------
                                            $94,490          $112,785
                                             ======           =======


                                      F-23

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
                  CONSOLIDATED STATEMENTS OF INCOME (UNAUDITED)
                             (dollars in thousands)



<TABLE>
                                                                        Nine Months Ended
                                                                   -----------------------------
                                                                   September 26,   September 25,
                                                                        1998            1999
                                                                   -------------   -------------
<S>                                                                <C>             <C>
Net sales related to products......................................   $128,478        $139,269
Net sales related to services......................................     17,041          21,827
                                                                      --------        --------
Total net sales....................................................    145,519         161,096
                                                                      --------        --------
Costs and expenses
   Cost of products sold...........................................     80,067          84,557
   Cost of services provided.......................................     10,974          12,673
   Selling general and administrative..............................     25,202          29,414
   Amortization of goodwill and intangibles........................      1,036           1,114
                                                                        ------          ------
Operating income...................................................     28,240          33,338

Other income (expense)
   Other income....................................................         --           1,441
   Interest income.................................................        659             496
   Interest expense................................................       (311)           (207)
   Loss from foreign currency, net.................................       (127)           (143)
                                                                        ------          ------
Income before income taxes, minority interests and earnings
   from equity investments.........................................     28,461          34,925
Provision for income taxes.........................................     11,280          16,903

Income before minority interests and earnings from equity
   investments.....................................................     17,181          18,022
Minority interests.................................................         (8)            (10)
Earnings from equity investments...................................      1,286           1,940
                                                                        ------          ------
Net income.........................................................    $18,459         $19,952
                                                                        ======          ======
</TABLE>



                 See Notes to Consolidated Financial Statements.

                                      F-24

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
                     CONSOLIDATED BALANCE SHEET (UNAUDITED)
                             (dollars in thousands)

<TABLE>
                                                                                September 25,
                                                                                     1999
                                                                                -------------
Assets
<S>                                                                             <C>
   Current assets
     Cash and cash equivalents...................................................  $  3,457
     Trade receivables, less allowances of $854..................................    33,820
     Inventories.................................................................    28,577
     Deferred income taxes.......................................................     5,432
     Due from affiliates.........................................................       966
     Other current assets........................................................     5,051
                                                                                    -------
     Total current assets........................................................    77,303

     Property, plant and equipment, net..........................................    79,349
     Goodwill and other intangibles, less accumulated amortization of $6,960.....    16,212
     Investments in affiliates...................................................    19,385
     Other assets................................................................    18,122
                                                                                    -------
       Total assets..............................................................  $210,371
                                                                                    =======
Liabilities and shareholder's equity
   Current liabilities
     Current portion of long-term debt...........................................  $    166
     Current portion of capital lease obligations................................       167
     Accounts payable............................................................     5,992
     Accrued compensation........................................................    11,015
     Accrued ESLIRP..............................................................     5,845
     Deferred income.............................................................     4,550
     Accrued restructuring.......................................................       354
     Accrued liabilities.........................................................    12,410
     Accrued income taxes........................................................    16,208
       Total current liabilities.................................................    56,707
   Long-term debt................................................................        --
   Capital lease obligations.....................................................       700
   Other long-term liabilities...................................................     3,706
                                                                                    -------
       Total liabilities.........................................................    61,113
                                                                                    -------
   Commitments and contingencies (Note 3)
   Minority interests............................................................       293

Shareholder's equity
   Common stock, par value $1 per share, 1,000 shares issued.....................         1
   Capital in excess of par value................................................    17,836
   Retained earnings.............................................................   142,422
   Accumulated other comprehensive income........................................   (11,294)
                                                                                    -------
     Total shareholder's equity..................................................   148,965
                                                                                    -------
       Total liabilities and shareholder's equity................................  $210,371
                                                                                    =======
</TABLE>

                 See Notes to Consolidated Financial Statements.

                                      F-25

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
                CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED)
                             (dollars in thousands)

<TABLE>
                                                                          Nine Months Ended
                                                                    ------------------------------
                                                                    September 26,    September 25,
                                                                         1998             1999
                                                                    -------------    -------------
<S>                                                                 <C>              <C>
Cash flows relating to operating activities
   Net income.......................................................   $ 18,459         $ 19,952
   Adjustments to reconcile net income to net cash provided
   by operating activities:
     Depreciation and amortization..................................      7,932            8,701
     Provision for doubtful accounts................................        248               13
     Gain from sale of facilities...................................                      (1,441)
     Earnings from equity investments...............................     (1,286)          (1,940)
     Minority interests.............................................          8               10
     Deferred income taxes..........................................       (634)              --
     Stock compensation expense.....................................        159              124
     Property, plant, and equipment write downs.....................         --              324
   Change in assets and liabilities
     Trade receivables..............................................     (3,298)          (3,022)
     Inventories....................................................       (683)           1,232
     Due from affiliates............................................        153             (264)
     Other current assets...........................................     (1,255)          (2,115)
     CVS of life insurance..........................................     (3,585)            (439)
     Other assets...................................................       (464)            (510)
     Accounts payable...............................................        910           (4,767)
     Accrued compensation...........................................      1,640             (605)
     Accrued ESLIRP.................................................        519              688
     Deferred income................................................        671            1,130
     Accrued restructuring..........................................     (1,425)            (759)
     Accrued liabilities............................................      1,687            1,079
     Accrued income taxes...........................................      4,259            2,211
     Other long-term liabilities....................................       (529)             (50)
                                                                         ------           ------
       Net cash provided by operating activities....................     23,486           19,552
                                                                         ------           ------
Cash flows relating to investing activities
   Dividends received from equity investments.......................        681              815
   Proceeds from sale of facilities                                          --            1,860
   Capital expenditures.............................................     (5,834)          (7,426)
   Cash paid for acquisition of businesses..........................     (9,114)               0
                                                                         ------           ------
   Net cash used in investing activities............................    (14,267)          (4,751)
                                                                         ------           ------

Cash flows relating to financing activities
   Proceeds from long-term debt.....................................        171               --
   Payments on long-term debt.......................................     (1,120)            (312)
   Payments on capital lease obligations............................        (94)             (90)
   Net activity with Bausch & Lomb..................................     (1,369)         (34,152)
                                                                         ------           ------
     Net cash used in financing activities..........................     (2,412)         (34,554)
                                                                         ------           ------
Effect of exchange rate changes on cash and cash equivalents........        462           (1,601)
                                                                         ------           ------
Net change in cash and cash equivalents.............................      7,269          (21,354)
                                                                         ------           ------
Cash and cash equivalents, beginning of year........................     17,915           24,811
                                                                         ------           ------
Cash and cash equivalents, end of year..............................    $25,184          $ 3,457
                                                                         ======           ======
Supplemental cash flow information
   Cash paid for taxes..............................................    $ 2,202          $ 3,316
   Cash paid for interest...........................................        161              207
</TABLE>

                 See Notes to Consolidated Financial Statements.

                                      F-26

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
        NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS -- (UNAUDITED)
                             (dollars in thousands)

1.   Basis of Presentation

     The consolidated balance sheet at September 25, 1999 and the consolidated
statements of income and of cash flows for the nine months ended September 26,
1998 and September 25, 1999 are unaudited, and certain information and footnote
disclosure related thereto normally included in financial statements prepared in
accordance with generally accepted accounting principles, have been omitted. In
the opinion of management, the accompanying unaudited consolidated financial
statements were prepared following the same policies and procedures used in the
preparation of the audited financial statements and reflect all adjustments
(consisting of normal recurring adjustments) considered necessary to present
fairly the financial position of the Company. The results of operations for the
interim periods are not necessarily indicative of the results for the entire
fiscal year.

2.   Supplemental Balance Sheet Information

     The composition of inventories is as follows:

                                                           September 25,
                                                                1999
                                                           -------------
     Raw materials and supplies...........................      $4,228
     Work in process......................................         988
     Finished products....................................      23,361
                                                                ------
     Net inventories......................................     $28,577
                                                                ======

     The composition of property, plant and equipment is as follows:

                                                           September 25,
                                                               1999
                                                           -------------
Land......................................................      $7,329
Buildings.................................................      89,014
Machinery and equipment...................................      76,648
Leasehold improvements....................................       3,746
Furniture and fixtures....................................       1,595
Vehicles..................................................       2,843
Construction in progress..................................       6,434
                                                               -------
                                                               187,609
Less accumulated depreciation.............................    (108,260)
                                                               -------
Net property, plant and equipment.........................    $ 79,349
                                                               =======


3.   Commitments and Contingencies

        Litigation

     Various lawsuits, claims and proceedings of a nature considered normal to
its business are pending against the Company. In the opinion of management, the
outcome of such proceedings and litigation currently pending will not materially
affect the Company's consolidated financial statements. The most potentially
significant claim is described below.

                                      F-27

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
        NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS -- (UNAUDITED)
                             (dollars in thousands)
                                   (continued)


3.   Commitments and Contingencies (continued)


     The Company is currently under a court order issued June 1997 to remove
its primate operations from two islands located in the Florida Keys. The
mandate asserts that the Company's operations have contributed to the
defoliation of certain protected plant life. Reserves of $218 are included in
the restructuring reserve recorded in the accompanying consolidated financial
statements to provide for any exposures in connection with the relocation and
refoliation.


4.   Business Segment Information

     The following table presents sales and other financial information by
product line segment for the nine months ended September 26, 1998 and September
25, 1999. Sales to unaffiliated customers represent net sales originating in
entities primarily engaged in either provision of research models or biomedical
products and services.

                                                 1998          1999
                                                ------        ------
      Research models
         Net sales.........................    $103,205      $109,177
         Operating income..................      26,281        27,977
         Total assets......................     182,761       157,284
         Depreciation and amortization.....       5,738         6,044
         Capital expenditures..............       4,112         4,282
      Biomedical products and services
         Net sales.........................    $ 42,314      $ 51,919
         Operating income..................       7,347        11,553
         Total assets......................      39,331        53,087
         Depreciation and amortization.....       2,194         2,657
         Capital expenditures..............       1,722         3,144


     A reconciliation of segment operating income to consolidated operating
income is as follows:

                                                 1998          1999
                                                ------        ------
         Total segment operating income....     $33,628       $39,530
         Unallocated corporate overhead....      (5,388)       (6,192)
                                                 ------        ------
         Consolidated operating income.....     $28,240       $33,338
                                                 ======        ======

5.   Comprehensive Income

     The components of comprehensive income for the nine-month periods ended
September 26, 1998 and September 25, 1999 are set forth below:

                                                 1998          1999
                                                ------        ------
         Net income                             $18,459       $19,952
         Foreign currency translation                20        (4,940)
                                                 ------        ------
         Comprehensive income                   $18,479       $15,012
                                                 ======        ======

                                      F-28

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
        NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS -- (UNAUDITED)
                             (dollars in thousands)
                                   (continued)


6.   Other Income

     During the nine months ended September 25, 1999, the Company recorded a
gain of $1.4 million on the sale of certain facilities located in Florida and
The Netherlands.

7.   Restructuring Reserve

     During the nine months ended September 25, 1999, the Company charged
approximately $759 against the restructuring reserve for costs previously
reserved for. As of September 25, 1999, the remaining restructuring reserve
amounted to $354, comprised primarily of scheduled severance payments and
relocation and refoliation costs. Such payments will be substantially complete
by the end of the year.

8.   Subsequent Events

     On September 29, 1999 CRL Acquisition LLC, an affiliate of DLJ Merchant
Banking Partners II, L.P., consummated a transaction in which it acquired 87.5%
of the common stock of Charles River Laboratories, Inc. from Bausch & Lomb for
approximately $443 million. This transaction was effected through Charles River
Laboratories Holdings, Inc. ("Holdings"), a holding company with no operations
or assets other than its ownership of 100% of the Company's outstanding stock.
This transaction will be accounted for as a leveraged recapitalization, which
will have no impact on the historical basis of the Company's assets and
liabilities. In addition, concurrent with the transaction, the Company purchased
all of the outstanding shares of common stock of SBI Holdings, Inc. ("Sierra"),
a pre-clinical biomedical services company, for $24.0 million. This acquisition
will be accounted for as a purchase business combination with the operating
results of Sierra being included in the Company's consolidated operating results
beginning on the effective date of the acquisition. These transactions are
hereafter referred to as the "Acquisitions".

     The Acquisitions and related transaction fees and expenses were funded as
follows:

     o   issuance of 150,000 units, each consisting of a $1,000 principal amount
         of 13.5% senior subordinated note (the Series A Note Offering) and one
         warrant to purchase 3.942 shares of common stock of Holdings;

     o   borrowings by the Company of $162.0 million under a new senior secured
         credit facility;

     o   an equity investment of $92.4 million in Holdings;

     o   senior discount debentures with warrants issued by Holdings for $37.6
         million; and

     o   subordinated discount note issued by Holdings to Bausch & Lomb for
         $43.0 million.

     The Series A Note Offering (the "Notes") will mature on October 1, 2009.
The Notes will not be redeemable at the issuers' option prior to October 1,
2004. Thereafter, the Notes will be subject to redemption at any time at the
option of the issuer at redemption prices set forth in the Notes. Interest on
the Notes will accrue at the rate of 13.5% per annum and will be payable
semi-annually in arrears on October 1 and April 1 of each year, commencing on
April 1, 2000. The payment of principal and interest on the Notes will be
subordinated in right to the prior payment of all Senior Debt, as defined. The
senior secured credit facility includes a $40 million term loan A facility, a
$120 million term loan B facility and a $30 million revolving credit facility.
The term loan A facility will mature on October 1, 2005, the term loan B
facility will mature on October 1, 2007 and the revolving credit facility will
mature on October 1, 2005. Interest on the term loan A, term loan B and
revolving credit facility will accrue at

                                      F-29

<PAGE>


                        CHARLES RIVER LABORATORIES, INC.
        NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS -- (UNAUDITED)
                             (dollars in thousands)
                                   (continued)


either a base rate plus 1.75% or LIBOR plus 3.0%, at the Company's option (8.5%,
9.25% and 8.5%, respectively, at September 29, 1999) per annum and will be paid
quarterly in arrears commencing on December 30, 1999. A commitment fee in an
amount equal to 0.50% per annum on the daily average unused portion of the
revolving credit facility will be paid quarterly in arrears. Upon the occurrence
of a change in control, as defined, the issuer will be obligated to make an
offer to each holder of the Notes to repurchase all or any part of such holders'
Notes at an offer price in cash equal to 101% of the principal amount thereof,
plus accrued and unpaid interest. Restrictions under the Notes include certain
sales of assets, certain payments of dividends and incurrence of debt, and
limitations on certain mergers and transactions with affiliates. With respect to
the Notes and the senior secured credit facility, the Company will be required
to maintain certain financial ratios and covenants.

9.   Dividends from Foreign Subsidiaries

     During the nine months ended September 25, 1999, cash dividends totaling
$20,662 were remitted to the Company from several of its foreign subsidiaries.
Pursuant to the terms of the transaction more fully described in Note 8, such
dividends were, in turn, remitted by the Company to B&L. As the related amounts
had previously been considered permanently reinvested in the foreign
jurisdictions, the Company was required to provide additional taxes upon their
repatriation to the United States. In addition, during the nine months ended
September 25, 1999, an election was made by B&L to treat certain foreign
entities as branches for United States income tax purposes. As a result, all
previously untaxed accumulated earnings of such entities became immediately
subject to tax in the United States. The receipt of the cash dividends from the
foreign subsidiaries and the foreign tax elections made resulted in incremental
United States taxes of $1,974, net of foreign tax credits, during the nine
months ended September 25, 1999.

                                      F-30

<PAGE>

================================================================================




                                Offer to Exchange
                                 All Outstanding
               13 1/2% Series A Senior Subordinated Notes Due 2009
                                       for
               13 1/2% Series B Senior Subordinated Notes Due 2009

                        Charles River Laboratories, Inc.





                              --------------------
                                   PROSPECTUS
                              --------------------








                                              ,2000





- --------------------------------------------------------------------------------
We have not authorized any dealer, salesperson or other person to give you
written information other than this prospectus or to make representations as to
matters not stated in this prospectus. You must not rely on unauthorized
information. This prospectus is not an offer to sell these securities or our
solicitation of your offer to buy the securities in any jurisdiction where that
would not be permitted or legal. Neither the delivery of this prospectus nor any
sales made hereunder after the date of this prospectus shall create an
implication that the information contained herein or the affairs of the company
have not changed since the date hereof.
- --------------------------------------------------------------------------------



================================================================================

<PAGE>



The information in this prospectus is not complete and may be changed. We may
not sell these securities until the registration statement filed with the
Securities and Exchange Commission is effective. This prospectus is not an offer
to sell these securities and we are not soliciting offers to buy these
securities in any state where the offer or sale is not permitted.


              [ALTERNATE FRONT COVER FOR MARKET-MAKING PROSPECTUS]
                 SUBJECT TO COMPLETION, DATED JANUARY 11, 2000
                        Charles River Laboratories, Inc.
                                  $150,000,000
               13 1/2% Series B Senior Subordinated Notes Due 2009

PROSPECTUS
- --------------------------------------------------------------------------------

The Company:

o  We are a global market leader in the commercial production and supply of
   animal research models for use in the discovery, development and testing of
   new pharmaceuticals. We are also a supplier of related biomedical products
   and services.

o  Charles River Laboratories, Inc.
   251 Ballardvale Street
   Wilmington, MA 01887
   (978) 658-6000

o  We were acquired in September 1999 by a group of investors including DLJ
   Merchant Banking Partners II, L.P.

The Offering:

o  We issued the notes in      , 1999, in an exchange offer registered under
   the Securities Act of 1933 pursuant to which the notes were exchanged for
   substantially identical notes originally issued in a private offering on
   September 23, 1999.

o  We used the net proceeds of the private offering, together with an equity
   investment of $105.6 million, to fund our recapitalization, our acquisition
   of SBI Holdings, Inc. and to pay fees and expenses related to the
   recapitalization and acquisition. The remaining net proceeds were used for
   general corporate purposes and initially were temporarily invested in
   short-term securities.

The Senior Subordinated Notes:

o  Maturity: October 1, 2009.

o  Interest Payments: semi-annually in cash in arrears on October 1 and April 1,
   commencing on April 1, 2000.

o  Redemption: we can redeem the notes on or after October 1, 2004. In addition,
   we can redeem up to 35% of the notes prior to October 1, 2002, with the net
   proceeds of a public equity offering. Holders of the notes may also require
   us to redeem all or part of such holder's notes upon a change of control.

o  Ranking: the notes will be general unsecured obligations, junior in right of
   payment to $163.3 million of senior indebtedness and secured indebtedness,
   including any borrowings and reimbursement obligations under our new credit
   facility, and the liabilities of our subsidiaries.


     This investment involves risk. See Risk Factors beginning on page 13.


Neither the Securities and Exchange Commission nor any state securities
commission has approved or disapproved of the securities or passed upon the
adequacy or accuracy of this prospectus. Any representation to the contrary is a
criminal offense.

     This prospectus will be used by Donaldson, Lufkin & Jenrette Securities
Corporation in connection with offers and sales in market-making transactions at
negotiated prices related to prevailing market prices. There is currently no
public market for the notes. This prospectus may also be used by DLJ Investment
Partners, L.P., DLJ Investment Funding, Inc., and DLJ ESC II L.P. to comply with
their prospectus delivery requirements of the Securities Act in connection with
any resale transaction. We do not intend to list the notes on any securities
exchange or to seek admission thereof to trading in the National Association of
Securities Dealers Automated Quotation System. Donaldson, Lufkin & Jenrette
Securities Corporation has advised us that it is currently making a market in
the notes; however, it is not obligated to do so and may stop at any time.
Donaldson, Lufkin & Jenrette Securities Corporation may act as principal or
agent in any such transaction. We will not receive the proceeds of the sale of
the notes but will bear the expenses of registration.

- --------------------------------------------------------------------------------
               Donaldson, Lufkin & Jenrette Securities Corporation


The date of this Prospectus is              , 2000.


<PAGE>


                [ALTERNATE SECTIONS FOR MARKET-MAKING PROSPECTUS]

No public trading market for the notes exists

     There is no existing trading market for the notes, and we cannot assure you
about the future development of a market for the notes or your ability to sell
the notes or the price at which you may be able to sell your notes. If such
market were to develop, the notes could trade at prices that may be higher or
lower than the initial offering price of the notes depending on many factors,
including prevailing interest rates, our operating results and the market for
similar securities. Although it is not obligated to do so, Donaldson, Lufkin &
Jenrette Securities Corporation ("DLJSC") intends to make a market in the notes.
Any such market-making activity may be discontinued at any time, for any reason,
without notice at the sole discretion of DLJSC. We do not intend to list the
notes on any securities exchange or to seek admission thereof to trading in the
National Association of Securities Dealers Automated Quotation System. No
assurance can be given as to the liquidity of or the trading market for the
notes.

     DLJSC may be deemed to be our "affiliate" (as defined in the Securities
Act) and, as such, may be required to deliver a prospectus in connection with
its market-making activities in the notes. Pursuant to the registration rights
agreement that we signed with DLJSC in connection with the initial sale of the
new notes, we have agreed to use our best efforts to file and maintain a
registration statement that would allow DLJSC to engage in market-making
transactions in the notes for a period ending no sooner than the date on which
DLJSC is no longer deemed to be such an "affiliate." We have agreed to bear
substantially all the costs and expenses related to registration.

                                USE OF PROCEEDS

     This prospectus is delivered in connection with the sale of the notes by
DLJSC in market-making transactions. This prospectus may also be used by DLJ
Investment Partners, L.P., DLJ Investment Funding, Inc., and DLJ ESC II L.P. to
comply with their prospectus delivery requirements of the Securities Act in
connection with any resale transaction. We will not receive any of the proceeds
from such transactions.

                             PLAN OF DISTRIBUTION

     This prospectus is to be used by DLJSC in connection with offers and sales
of the new notes in market-making transactions effected from time to time. DLJSC
may act as a principal or agent in such transactions, including as agent for the
counterparty when acting as principal or as agent for both counterparties, and
may receive compensation in the form of discounts and commissions, including
from both counterparties when it acts as agent for both. Such sales will be made
at prevailing market prices at the time of sale, at prices related thereto or at
negotiated prices. This prospectus may also be used by DLJ Investment Partners,
L.P., DLJ Investment Funding, Inc., and DLJ ESC II L.P. to comply with their
prospectus delivery requirements of the Securities Act in connection with any
resale transaction.

     DLJ Merchant Banking, an affiliate of DLJSC, and some of its affiliates
beneficially own approximately 71.9% of the common stock of Charles River. DLJSC
acted as financial advisor to Charles River in the acquisition, and as an
initial purchaser of the old notes. Charles River paid customary fees to DLJSC
as compensation for its services as financial advisor and initial purchaser. The
aggregate amount of all fees paid to DLJSC in connection with the acquisition
and the related financing was approximately $3.6 million plus
out-of-pocket-expenses. Charles River has agreed to engage DLJSC as its
exclusive financial advisor for a period of five years beginning upon the
closing of the merger. Charles River and its subsidiaries may from time to time
enter into financial advisory or other investment banking relationships with
DLJSC or one of its affiliates pursuant to which DLJSC or its affiliates will
receive customary fees and will be entitled to reimbursement for all reasonable
disbursements and out-of-pocket expenses incurred in connection therewith.
Charles River expects that any such arrangement will include provisions for the
indemnification of DLJSC against some liabilities, including liabilities under
the federal securities laws. See "Relationships and Related Party Transactions."


<PAGE>



     DLJSC has informed Charles River that it does not intend to confirm sales
of the new notes to any accounts over which it exercises discretionary authority
without the prior specific written approval of such transactions by the
customer.

     Charles River has been advised by DLJSC that, subject to applicable laws
and regulations, DLJSC currently intends to make a market in the new notes
following completion of the exchange offer. However, DLJSC is not obligated to
do so and any such market-making may be interrupted or discontinued at any time
without notice. In addition, such market-making activity will be subject to the
limits imposed by the Securities Act and the Exchange Act. There can be no
assurance that an active trading market will develop or be sustained. See "Risk
Factors--No public market for the new notes exists."

     DLJSC and Charles River have entered into the Registration Rights Agreement
with respect to the use by DLJSC of this prospectus. Pursuant to such agreement,
Charles River agreed to bear all registration expenses incurred under such
agreement, and Charles River agreed to indemnify DLJSC against some liabilities,
including liabilities under the Securities Act.


<PAGE>


                    [BACK COVER FOR MARKET-MAKING PROSPECTUS]

================================================================================




               13 1/2% Series B Senior Subordinated Notes Due 2009
                        Charles River Laboratories, Inc.





                              --------------------
                                   PROSPECTUS
                              --------------------






               Donaldson, Lufkin & Jenrette Securities Corporation





                                                 , 2000





- --------------------------------------------------------------------------------
We have not authorized any dealer, salesperson or other person to give you
written information other than this prospectus or to make representations as to
matters not stated in this prospectus. You must not rely on unauthorized
information. This prospectus is not an offer to sell these securities or our
solicitation of your offer to buy the securities in any jurisdiction where that
would not be permitted or legal. Neither the delivery of this prospectus nor any
sales made hereunder after the date of this prospectus shall create an
implication that the information contained herein or the affairs of Charles
River have not changed since the date hereof.
- --------------------------------------------------------------------------------


================================================================================

<PAGE>


                                     PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 13. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION

     The following is an itemization of all estimated expenses incurred or
expected to be incurred by the Registrant in connection with the issuance and
distribution of the securities being registered hereby, other than underwriting
discounts and commissions.

Item                                                Amount
- ----                                               --------
SEC Registration Fee..........................   $ 41,700.00
Printing and Engraving Costs..................    100,000.00
Trustee Fees..................................     50,000.00
Legal Fees and Expenses.......................    100,000.00
Accounting Fees and Expenses..................     50,000.00
Miscellaneous.................................     50,000.00
                                                  ----------
  Total.......................................   $391,700.00
                                                  ==========


ITEM 14. INDEMNIFICATION OF OFFICERS AND DIRECTORS.

     The certificate of incorporation of Charles River contains a provision
eliminating or limiting director liability to the company and its stockholders
for monetary damages arising from acts or omissions in the director's capacity
as a director. This provision may not, however, eliminate or limit the personal
liability of a director:

     o  for any breach of such director's duty of loyalty to the company or its
        stockholders;

     o  for acts or omissions not in good faith or which involve intentional
        misconduct or a knowing violation of law;

     o  under the Delaware statutory provision making directors personally
        liable, under a negligence standard, for unlawful dividends or unlawful
        stock purchases or redemptions; or

     o  for any transaction from which the director derived an improper personal
        benefit.

As a result of this provision, the ability of the company, or a stockholder
thereof, to successfully prosecute an action against a director for breach of
his duty of care is limited. However, the provision does not affect the
availability of equitable remedies such as an injunction or rescission based
upon a director's breach of his duty of care. The SEC has taken the position
that the provision will have no effect on claims arising under the federal
securities laws.

     In addition, the certificate of incorporation of Charles River provides for
mandatory indemnification rights, subject to limited exceptions, to any director
or executive officer of the company who (by reason of the fact that he or she is
a director or officer) is involved in a legal proceeding of any nature. Such
indemnification rights include reimbursement for expenses incurred by such
director or officer in advance of the final disposition of such proceeding in
accordance with the applicable corporate law.

     Charles River provides insurance from commercial carriers against some
liabilities incurred by the directors and officers of Charles River.

ITEM 15. RECENT SALES OF UNREGISTERED SECURITIES.

     On September 29, 1999, the Registrant sold 150,000 units consisting of
13 1/2% notes due 2009 (the "old notes") and warrants to purchase 591,366 shares
of common stock of Charles River Laboratories Holdings, Inc. for an aggregate
principal amount of $150,000,000 to Donaldson, Lufkin & Jenrette Securities
Corporation (the "initial purchaser") in

<PAGE>


a private placement in reliance on Section 4(2) under the Securities Act, at an
offering price of $1,000 per unit. The old notes were immediately resold by the
initial purchaser in transactions not involving a public offering.

ITEM 16. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES.

     (a) Exhibits.

  Exhibit
   Number
  -------
    1.1*     Registration Rights Agreement, dated as of September 29, 1999,
             between Charles River and Donaldson, Lufkin & Jenrette Securities
             Corporation, as Initial Purchaser.
    2.1*     Recapitalization Agreement, dated as of July 25, 1999, among
             Charles River, Bausch & Lomb Incorporated, and other parties
             listed therein.
    2.2*     Amendment No. 1 to Recapitalization Agreement, dated as of
             September 29, 1999 by Bausch & Lomb Incorporated and CRL
             Acquisition LLC.
    3.1.1*   Certificate of Incorporation of Charles River Laboratories, Inc.
    3.1.2*   By-laws of Charles River Laboratories, Inc.
    4.1*     Investors' Agreement, dated as of September 29, 1999, among
             Charles River Laboratories Holdings, Inc. and the shareholders
             named therein.
    4.2*     Indenture, dated as of September 29, 1999 among Charles River, and
             the Trustee.
    4.3*     Form of new note (included in Exhibit 4.2)
    5.1*     Opinion of Davis Polk & Wardwell with respect to the new notes.
   10.3*     Credit Agreement, dated as of September 29, 1999, among Charles
             River, the various financial institutions that are or may become
             parties as lenders thereto, DLJ Capital Funding, Inc., as lead
             arranger, sole book runner and syndication agent for the lenders,
             Union Bank of California, N.A., as administrative agent for the
             lenders, and National City Bank, as documentation agent for the
             lenders.
   10.5*     Purchase Agreement between Charles River and Donaldson, Lufkin &
             Jenrette Securities Corporation as Initial Purchaser.
   10.6**    Joint Venture Agreement between Ajinomoto Co., Inc. and Charles
             River Breeding Laboratories, Inc. dated June 24, 1981, and
             ancillary agreements, amendments and addendums. June 15, 1987
             Amendment Agreement, Amending the Joint Venture Agreement. January
             17, 1994 Letter Amendment of Joint Venture Agreement. August 30,
             1996 Addendum to the Joint Venture Agreement. License and
             Technical Assistance Agreement CRL Breeding Labs and Ajinomoto
             Co., Inc. Amendment Agreement, dated March 24, 1978.
   10.7*     Merck Primate Supply Agreement between Merck & Co., Inc. and
             Charles River Laboratories, Inc. dated September 30, 1994.
   10.8*     Amended and Restated Stock Purchase Agreement among Charles River
             Laboratories, Inc. and SBI Holdings, Inc. and its stockholders
             dated September 4, 1999.

   10.9**    Ground Lease between HIC Associates (Lessor) and Charles
             River Laboratories, Inc. (Lessee) dated June 5, 1992; and
             Assignment and Assumption Agreement between Charles River
             Partners, L.P. (Assignor) and Wilmington Partners L.P.
             (Assignees) dated December 22, 1993.

   10.10*    Amended and Restated Distribution Agreement between Charles
             River BRF, Inc., Charles River Laboratories, Inc., Bioculture
             Mauritius Ltd. and Mary Ann and Owen Griffiths, dated December
             23, 1997.
   10.11*    Supply Agreement for non-human primates among Sierra Biomedical,
             Inc. and Scientific Resources International, Ltd., dated March
             18, 1997.
   12.1**    Computation of Ratio of Earnings to Fixed Charges
   12.2**    Computation of Ratio of Total Debt to Adjusted EBITDA
   12.3**    Computation of Ratio of Adjusted EBITDA to Cash Interest Expense
   21.1**    Subsidiaries of Charles River
   23..1*    Consent of Davis Polk & Wardwell (contained in their opinion
             filed as Exhibit 5.1).
   23.2**    Consent of PricewaterhouseCoopers LLP.
   24.1*     Power of Attorney (Included in Part II of this Registration
             Statement under the caption "Signatures").
   25.1*     Statement of Eligibility of State Street Bank and Trust Company on
             Form T-1.
   27.1*     Financial Data Schedule for Charles River Laboratories, Inc.
   99.1*     Form of Letter of Transmittal


<PAGE>


   99.2*     Form of Notice of Guaranteed Delivery
   99.3*     Form of Letter to Clients
   99.4*     Form of Letter to Nominees
   99.5*      Form of Instructions to Registered Holder and/or Book-Entry
             Transfer Participant from Owner

- ------------
*    Previously filed.
**   Filed herewith.

     (b) Financial Statement Schedules.

     Schedule II Valuation and Qualifying Accounts

     Other schedules are omitted because they are not applicable.


<PAGE>


ITEM 17. UNDERTAKINGS.

     The undersigned Registrant hereby undertakes:

     (a) (1) To file, during any period in which offers or sales are being made,
a post-effective amendment to this Registration Statement:

             (x) To include any prospectus required by section 10(a)(3) of the
                Securities Act of 1933;

             (y) To reflect in the prospectus any facts or events arising after
                 the effective date of the Registration Statement (or the most
                 recent post-effective amendment thereof) which, individually or
                 in the aggregate, represent a fundamental change in the
                 information set forth in the Registration Statement.

             (z) To include any material information with respect to the plan of
                 distribution not previously disclosed in the Registration
                 Statement or any material change to such information in the
                 Registration Statement;

         (2) That, for the purpose of determining any liability under the
             Securities Act of 1933, each such post-effective amendment shall be
             deemed to be a new registration statement relating to the
             securities offered therein, and the offering of such securities at
             the time shall be deemed to be the initial bona fide offering
             thereof.

         (3) To remove from registration by means of a post-effective amendment
             any of the securities being registered which remain unsold at the
             termination of the offering.

         Insofar as indemnification for liabilities arising under the Securities
         Act of 1933 may be permitted to directors, officers and controlling
         persons of the Registrant pursuant to the provisions described in Item
         510 of Regulation S-K, or otherwise, the Registrant has been advised
         that in the opinion of the Securities and Exchange Commission such
         indemnification is against public policy as expressed in the Act and
         is, therefore, unenforceable. In the event that a claim for
         indemnification against such liabilities (other than the payment by the
         Registrant of expenses incurred or paid by a director, officer or
         controlling person of the Registrant in the successful defense of any
         action, suit or proceeding) is asserted by such director, officer or
         controlling person in connection with the securities being registered,
         the Registrant will, unless in the opinion of its counsel the matter
         has been settled by controlling precedent, submit to a court of
         appropriate jurisdiction the question whether such indemnification by
         it is against public policy as expressed in the Act and will be
         governed by the final adjudication of such issue.


<PAGE>


                                   SIGNATURES

     Pursuant to the requirements of the Securities Act, the registrant has duly
caused this amendment to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Wilmington, State of Massachusetts, on January
2000.


                                       CHARLES RIVER LABORATORIES, INC.

                                       By: /s/ Thomas F. Ackerman
                                           ---------------------------
                                           Chief Financial Officer


                                POWER OF ATTORNEY

     Pursuant to the requirements of the Securities Act of 1933, this amendment
has been signed below by the following persons in the capacities and on the
dates indicated.

<TABLE>
         Signature                              Title                                  Date
         ---------                              -----                                  ----
<S>                           <C>                                                <C>
/s/ James C. Foster           President, Chief Executive Officer (Principal      January 11, 2000
- --------------------------    Executive Officer) and Director
     James C. Foster

/s/ Thomas F. Ackerman        Chief Financial Officer (Principal Financial       January 11, 2000
- --------------------------    Officer) and Vice President, Finance and
   Thomas F. Ackerman         Administration (Principal Accounting Officer)


                              Director                                           January 11, 2000
- --------------------------
   Reid S. Perper

                              Director                                           January 11, 2000
- --------------------------
   Thompson Dean

                              Director                                           January 11, 2000
- --------------------------
   Robert Cawthorn

By /s/ Thomas F. Ackerman     Director                                           January 11, 2000
- --------------------------
   Thomas F. Ackerman
   Attorney-in-fact
</TABLE>


<PAGE>


                        Allowance for Doubtful Accounts
<TABLE>

- ----------------------------------------------------------------------------------------------------------------------
<S>                    <C>           <C>           <C>           <C>          <C>            <C>            <C>
                       Balance at    Charged to    Charged to                                               Balance at
                       beginning     costs and       other                                                    end of
                       of period      expenses      accounts     Describe     Deductions      Describe        period
- ----------------------------------------------------------------------------------------------------------------------
                                                   (dollars in thousands)
- ----------------------------------------------------------------------------------------------------------------------
For the year ended
December 26, 1998
Allowance for
  Doubtful                                                                                   Recoveries/
  Accounts.........      $ 688         $ 265                     Provision      $ (55)       Write-offs       $ 898
- ----------------------------------------------------------------------------------------------------------------------
For the year ended
December 27, 1997
Allowance for
  Doubtful                                                                                   Recoveries/
  Accounts.........      $ 568         $ 192                     Provision      $ (72)       Write-offs       $ 688
- ----------------------------------------------------------------------------------------------------------------------
 For the year ended
December 28, 1996
Allowance for
  Doubtful                                                                                   Recoveries/
  Accounts.........      $ 490         $ 101                     Provision      $ (23)       Write-offs       $ 568
- ----------------------------------------------------------------------------------------------------------------------
</TABLE>


<PAGE>

                                Index to Exhibits

   Exhibit
    Number
   -------
     1.1*     Registration Rights Agreement, dated as of September 29, 1999,
              between Charles River and Donaldson, Lufkin & Jenrette Securities
              Corporation, as Initial Purchaser.
     2.1*     Recapitalization Agreement, dated as of July 25, 1999, among
              Charles River, Bausch & Lomb
               Incorporated, and other parties listed therein.
     2.2*     Amendment No. 1 to Recapitalization Agreement, dated as of
              September 29, 1999 by Bausch & Lomb Incorporated and CRL
              Acquisition LLC.
     3.1.1*   Certificate of Incorporation of Charles River Laboratories, Inc.
     3.1.2*   By laws of Charles River Laboratories, Inc.
     4.1*     Investors' Agreement, dated as of September 29, 1999, among
              Charles River Laboratories Holdings, Inc. and the shareholders
              named therein.
     4.2*     Indenture, dated as of September 29, 1999 among Charles River, and
              the Trustee.
     4.3*     Form of new note (included in Exhibit 4.2)
     5.1*     Opinion of Davis Polk & Wardwell with respect to the new notes.
    10.3*     Credit Agreement, dated as of September 29, 1999, among Charles
              River, the various financial institutions that are or may become
              parties as lenders thereto, DLJ Capital Funding, Inc., as lead
              arranger, sole book runner and syndication agent for the lenders,
              Union Bank of California, N.A., as administrative agent for the
              lenders, and National City Bank, as documentation agent for the
              lenders.
    10.5*     Purchase Agreement between Charles River and Donaldson, Lufkin &
              Jenrette Securities Corporation as Initial Purchaser.
    10.6**    Joint Venture Agreement between Ajinomoto Co., Inc. and Charles
              River Breeding Laboratories, Inc. dated June 24, 1981, and
              ancillary agreements, amendments and addendums. June 15, 1987
              Amendment Agreement, Amending the Joint Venture Agreement. January
              17, 1994 Letter Amendment of Joint Venture Agreement. August 30,
              1996 Addendum to the Joint Venture Agreement. License and
              Technical Assistance Agreement CRL Breeding Labs and Ajinomoto
              Co., Inc. Amendment Agreement, dated March 24, 1978.
    10.7*     Merck Primate Supply Agreement between Merck & Co., Inc. and
              Charles River Laboratories, Inc. dated September 30, 1994.
    10.8*     Amended and Restated Stock Purchase Agreement among Charles River
              Laboratories, Inc. and SBI Holdings, Inc. and its stockholders
              dated September 4, 1999.
    10.9**    Ground Lease between HIC Associates (Lessor) and Charles
              River Laboratories, Inc. (Lessee) dated June 5, 1992; and
              Assignment and Assumption Agreement between Charles River
              Partners, L.P. (Assignor) and Wilmington Partners L.P.
              (Assignees) dated December 22, 1993.
    10.10*    Amended and Restated Distribution Agreement between Charles
              River BRF, Inc., Charles River Laboratories, Inc., Bioculture
              Mauritius Ltd. and Mary Ann and Owen Griffiths, dated December
              23, 1997.
    10.11*    Supply Agreement for non-human primates among Sierra Biomedical,
              Inc. and Scientific Resources International, Ltd., dated March
              18, 1997.
    12.1**    Computation of Ratio of Earnings to Fixed Charges
    12.2**    Computation of Ratio of Total Debt to Adjusted EBITDA
    12.3**    Computation of Ratio of Adjusted EBITDA to Cash Interest Expense
    21.1**    Subsidiaries of Charles River
    23..1*    Consent of Davis Polk & Wardwell (contained in their opinion
              filed as Exhibit 5.1).
    23.2**    Consent of PricewaterhouseCoopers LLP.
    24.1*     Power of Attorney (Included in Part II of this Registration
              Statement under the caption "Signatures").
    25.1*     Statement of Eligibility of State Street Bank and Trust Company on
              Form T-1.
    27.1*     Financial Data Schedule for Charles River Laboratories, Inc.
    99.1*     Form of Letter of Transmittal


<PAGE>


   Exhibit
    Number
   -------
    99.2*     Form of Notice of Guaranteed Delivery
    99.3*     Form of Letter to Clients
    99.4*     Form of Letter to Nominees
    99.5*     Form of Instructions to Registered Holder and/or Book-Entry
              Transfer Participant from Owner

- ------------
*    Previously filed.
**   Filed herewith.


                                                                    EXHIBIT 10.6



                           JOINT VENTURE AGREEMENT




<PAGE>

                           JOINT VENTURE AGREEMENT

         THIS AGREEMENT, entered into this 24th day of June, 1981, between:

         AJINOMOTO CO., INC., a Japanese corporation having its principal
place of business at 5-8, Kyobashi 1-chome, Chuo-ku, Tokyo, Japan (hereinafter
referred to as "AJI")

                                      and

         THE CHARLES RIVER BREEDING LABORATORIES, INC., a Delaware corporation
having its principal place of business at 251 Ballardvale Street, Wilmington,
Massachusetts, U.S.A. (hereinafter referred to as "CRBL").

                             W I T N E S S E T H

         WHEREAS, CRBL has purchased from AJI four hundred thousand (400,000)
shares of Common Stock of CHARLES RIVER JAPAN, INC. (hereinafter referred to
as "CRJ") which shares represent fifty percent (50%) of the total outstanding
shares of CRJ; and

         WHEREAS, AJI and CRBL now each own fifty percent (50%,) of the
outstanding shares of CRJ and AJI and CRBL each wish to continue to own fifty
percent (50%) of such shares; and

         WHEREAS, AJI and CRBL wish to outline the terms of their joint
management of CRJ;


<PAGE>


         NOW, THEREFORE, in consideration of the foregoing and of the mutual
covenants and premises hereinafter set forth, the parties hereto agree as
follows:

                                  ARTICLE I

         The term "TERRITORY" shall mean any and all the countries listed in
Schedule A attached hereto and made a part hereof.


                                  ARTICLE II
                           DIRECTORS AND MANAGEMENT

         (1) CRJ has a Board of Directors consisting of ten directors. The
parties hereto agree that they will cast their votes as shareholders of CRJ in
such manner that the Board of Directors shall consist of an equal number of
persons designated by AJI and CRBL.

         (2) No remuneration shall be paid to directors of CRJ except those
who devote all their activities to the benefit of CRJ. Remuneration to be paid
to the full-time directors shall be fixed by agreement of both parties.

         (3) The parties hereto agree that they will cause their
representatives on the Board of Directors of CRJ to appoint a President who
shall be designated by AJI and accepted by CRBL. The President shall be a
Registered Representative Director.

                                     -2-

<PAGE>

         (4) The parties hereto agree that, at the request of CRBL, they will
cause their representatives on the Board of Directors of CRJ to appoint a
Senior Managing Director who shall be designated by CRBL and accepted by AJI;
that AJI and CRBL shall determine after mutual consultation the level of
compensation CRJ shall accord such person; provided, however, that CRBL may
accord such person an annual bonus in such amount as it shall determine from
time to time; and that, in addition to the President, the Senior Managing
Director shall be a Registered Representative Director. In the event CRBL does
not request the appointment of such a Senior Managing Director and CRJ is
therefore not required to compensate such a person, CRJ shall bear all
reasonable expenses associated with CRBL sending a director from its offices
in the United States to attend meetings of the Board of Directors in Japan,
including without limitation travel, meals and lodging expenses.

         (5) The parties hereto agree that they will vote their shares of CRJ
in such manner that at all times during the effective period of this Agreement
there shall be two statutory auditors (Kansayaku) of CRJ; one to be a person
designated by AJI and the other to be a person designated by CRBL.

         (6) The parties hereto agree that Arthur Andersen & Co. and Tetsuzo
Ota Co. shall be the independent public accountants of CRJ and together shall
examine and audit its

                                     -3-


<PAGE>


accounting books and records annually at the end of its fiscal year and shall
at the expense of CRJ prepare audit reports in English and Japanese and shall
furnish them to the parties hereto. In addition, CRBL may at its own expense
designate Arthur Andersen & Co., or such other independent auditor as it may
from time to time designate, to audit the books and records of CRJ or perform
such lesser procedure as may be required for the period ending October 31 each
year in order to provide the information necessary or appropriate for the
independent accountants of CRBL to express an opinion on the financial
statements of CRBL, and at such time CRJ shall cooperate fully with such
auditors of CRBL.

         CRJ shall keep complete books of account and records in accordance
with sound accounting practices employing standards, procedures and forms
conforming to international practice as approved by Arthur Andersen & Co. and
T. Ota & Co.
         (7) Minutes of all meetings of shareholders and of all meetings of
the Board of Directors shall be kept in both Japanese and English. At any
meeting of shareholders or of the Board of Directors at which a non-Japanese
speaking person is expected to be present, CRJ shall, at its own expense,
provide an official interpreter or interpreters.

         (8) In addition to such an interpreter or interpreters as set forth
in Paragraph (7) above, any shareholder and director shall have the right to
use its own interpreter at


                                     -4-


<PAGE>


its own expense at any meeting of shareholders and of the Board of Directors.

         (9) All regular and special reports relating to the financial and
technical operating results of CRJ, either submitted to the Board of Directors
or listed in Schedule B attached hereto and made a part hereof, shall be
prepared in both Japanese and English.


                                 ARTICLE III
                      ACTIONS BY THE BOARD OF DIRECTORS

         (1) The Board of Directors of CRJ has responsibility for and control
over the operation of CRJ as well as the establishment of the general plans of
operation in accordance with the Articles of Incorporation of CRJ. One more
than half of the total number of directors shall constitute a quorum for the
transaction of business and the affirmative vote of one more than half of the
total number of directors shall be the act of the Board of Directors at a
meeting at which a quorum is present.

         (2) The following matters require specific action by the Board of
Directors and the actions of any individual officer or director, including a
Registered Representative Director, shall not bind CRJ with respect to these
matters:

         --decide capital and operating budgets;

         --make loans, guarantee obligations, or borrow funds in an amount in
           excess of twenty million yen;


                                     -5-


<PAGE>


         --sell, lease, encumber or otherwise dispose of all or substantially
           all assets;

         --terminate a line of products or business or undertake a new line of
           products or business;

         --make any investment or capital expenditure, or series of related
           investments or capital expenditures on any single project, for
           amounts not included in the capital or operating budget in excess of
           twenty million yen;

         --issue or redeem stock;

         --submit a proposal for distribution of dividends to the
           shareholders;

         --take any action that may adversely affect the financial condition
           of the company;

         --matters not in the ordinary course of business; and

         --any other matters which the Board of Directors may determine
           require action by the Board of Directors.


                                     -6-


<PAGE>


                                  ARTICLE IV
                              PRE-EMPTIVE RIGHTS

         Upon recapitalization of CRJ or the issuance of newly authorized
capital stock of CRJ in excess of the initial authorized capital or the
issuance of any of the unissued authorized capital stock, AJI and CRBL shall
have pre-emptive rights to acquire such number of newly issued shares as shall
be consistent with their respective proportionate ownership of the capital
stock of CRJ.


                                  ARTICLE V
                          SALE OR TRANSFER OR SHARES


         So long as both CRBL and AJI own any shares of CRJ, each shall have
the right of first refusal with respect to the shares owned by the other and
each shall be obligated as follows. Such right of first refusal shall be
exercised in accordance with the following procedures:

         (1) A shareholder desiring to sell or transfer any or all of its
shares of CRJ (the Offering Shareholder) shall first give written notice to
the other shareholder of its desire to sell or transfer the shares of CRJ,
stating the name of the proposed transferee, the number of shares to be sold
or transferred and the price, terms and conditions of the proposed sale or
transfer.

         (2) The other shareholder shall then have the option, to be exercised
within ninety (90) days from the receipt of notice from the Offering
Shareholder, to purchase all of the


                                     -7-


<PAGE>


offered shares at the price and on the terms and conditions specified in the
notice given by the Offering Shareholder.

         (3) If the offered shares are not purchased by the other shareholder,
these shares may be sold or transferred by the Offering Shareholder at any
time within one hundred eighty (180) days from the date of the notice
referred to in paragraph (1) above to the transferee specified in such notice
at a price which is no lower, and on terms and conditions no more favorable,
than the price and terms and conditions specified therein.

         (4) It is understood and agreed that notwithstanding the foregoing
provisions of this Article V, either CRBL or AJI may sell or transfer all of
its shares of CRJ (but not in part) to a corporation in which such party holds
all of the total outstanding voting shares without the consent of the other
party or without taking the procedures set forth above, provided that the
transferee agrees to be bound by all of the provisions of this Agreement as if
it had been the original party hereto, and that the transferor shall remain
responsible for the performance of any of the obligations hereunder.


                                     -8-


<PAGE>


                                  ARTICLE VI
                          FINANCIAL RESPONSIBILITIES

         (1) Either of the parties hereto shall assume financial
responsibility to CRJ in proportion to its stockholding which shall include
direct loans to CRJ and guarantees in respect of CRJ borrowings, unless
otherwise determined by the Board of Directors, but which shall not include
reduction of royalties payable by CRJ under the License and Technical
Assistance Agreement and the Tradename and Trademark License Agreement dated
March 24, 1978 among CRBL, CRJ and AJI barring the case of specific agreement
in writing which may otherwise be made among the parties.

         (2) AJI agrees with CRBL that during and with respect to the two (2)
fiscal years commencing with the 1981 fiscal year, the burden of wage cost of
CRJ's employees dispatched from AJI (such wage cost is hereinafter referred to
as the "Wage Cost") shall be divided between CRJ and AJI as follows:

                                         CRJ                AJI
1981 Fiscal Year
(Commencing on April 1,
1981 and ending on
March 31, 1982)                          70%                 30%

1982 Fiscal Year
(Commencing on April 1,
1982 and ending on
March 31, 1983)                          75%                 25%

         AJI further agrees that with respect to 1983 and any subsequent
fiscal year, it shall continue to give to CRJ


                                     -9-


<PAGE>


financial assistance by means of assuming twenty-five percent (25%) of the
Wage Cost, provided that if CRJ's pretax profit as determined in accordance with
generally accepted accounting principles applied consistently and as reflected
in audited financial statements of CRJ (calculated on the basis of CRJ's burden
of the Wage Cost in that fiscal year) attains ten percent (10%) of gross sales
in the 1982 fiscal year or in any subsequent fiscal year, then AJI's burden of
the Wage Cost during that fiscal year which follows any fiscal year in which ten
percent (10%) pretax profit is attained shall be reduced by five percent (5%) of
the total Wage Cost from the percentage applied in the immediately preceding
year; such financial assistance by AJI at a percentage reduced from time to time
by each occurrence of attainment of ten percent (10%) pretax profit by CRJ to
continue until AJI's burden of the Wage Cost becomes zero by recurrence of
attainment of ten percent (10%) pretax profit by CRJ and consequential
reductions of AJI's burden of the Wage Cost as provided above.


                                     -10-


<PAGE>


                                  ARTICLE VII
                                NONCOMPETITION

         In order to foster and promote the attainment of the mutual aims and
objectives of AJI and CRBL with respect to CRJ, AJI and CRBL agree that during
the term of this Agreement and for a period of two (2) years after this
Agreement is terminated in accordance with Article X hereof or after either
party acquires all of the shares of CRJ, AJI and CRBL shall not, directly or
indirectly (through a firm, joint venture, company or business owned or
controlled by it or otherwise), except through CRJ, engage in the business in
the TERRITORY, as defined in Schedule A attached, to produce laboratory
animals and, or feed for laboratory animals which are reasonably competitive
with products sold by CRJ and shall not acquire in the TERRITORY an interest
in any firm, company or business organization producing, selling, promoting or
dealing in, laboratory animals and/or feed for laboratory animals which are
reasonably competitive with products sold by CRJ. Notwithstanding the
foregoing, if this Agreement shall be terminated pursuant to Paragraph (2) of
Article X, the terminating party shall not be subject to any restriction
provided above after the termination.


                                     -11-


<PAGE>


                                 ARTICLE VIII
                                ASSIGNABILITY

         Except as otherwise expressly provided in this Agreement, neither
this Agreement nor any rights under this Agreement shall be assignable or
transferable by AJI or CRBL without the prior written consent of the other;
provided, however, that in the case of any transfer of rights or obligations
under this Agreement pursuant to a merger or consolidation of AJI or CRBL, the
other party shall not unreasonably withhold its consent to such transfer if
the beneficial ownership and management of the proposed transferee and
proposed transferor are and will be substantially the same. Any assignment or
transfer under this Article shall become effective only after necessary
authorization by the Government of Japan shall have been obtained.


                                  ARTICLE IX
                                 ARBITRATION


         (1) All disputes, controversies, or differences which may arise
between the parties, out of or in relation to or in connection with this
Agreement, or for the breach thereof, shall be finally settled by arbitration
pursuant to the Japan-American Trade Arbitration Agreement, of September 16,
1952, by which each party hereto is bound.

         (2) Such arbitration shall be held in the City of Boston,
Massachusetts if the demand for arbitration is


                                     -12-


<PAGE>


received by CRBL and in Tokyo if the demand is received by AJI.

         (3) Nothing herein contained shall be construed as preventing either
party hereto from instituting legal action against the other for a temporary
injunction, pending final settlement of any dispute, difference or question by
arbitration.

         (4) Notwithstanding Paragraph (1) of this Article, in the event that
CRJ should become deadlocked in the management of the corporate affairs for
any reason whatsoever, or that the managing or disposing of CRJ property
should be grossly improper and the existence of CRJ should be thereby in
danger, the parties hereto shall not be precluded from instituting a lawsuit
for dissolution of CRJ in the competent court in Japan in accordance with
Paragraph 1 of Article 406-2 of the Commercial Code of Japan.


                                  ARTICLE X
                                 TERMINATION


         (1) Either party hereto shall have the right to terminate this
Agreement forthwith by giving the other written notice to that effect upon the
occurrence of any of the following events to CRJ:

         (a) Termination of business by unanimous decision of the shareholders;

         (b) Dissolution or liquidation;

         (c) Adjudication of bankruptcy;


                                     -13-


<PAGE>


         (d) The appointment of any trustee, receiver or liquidator for
             substantially all of the assets of the business of CRJ;

         (e) The attachment, sequestration, execution or seizure of
             substantially all of the assets of CRJ, which attachment,
             sequestration, execution or seizure is not released within thirty
             (30) days from the institution thereof.

         (2) Upon default by either party in the performance of any obligation
hereunder to be performed by such party, the other party may give notice in
writing to the party in default specifying the thing or matter in default.
Upon receipt of such notice, the receiving party may elect either to cure the
default within one (1) month or sooner if practicable following the giving of
such notice or may notify the other party of its intention to seek arbitration
pursuant to Article IX of this Agreement with respect to the alleged default.
In the event the arbitration proceedings conclude that such party is in
default, that party has one month to cure the default. At the conclusion of
either one-month period, if the default has not been cured, the party first
giving notice may give further written notice to such other party terminating
this Agreement, in which event this Agreement shall terminate on the date
specified in such further notice. Such termination right shall be in addition
to and not in substitution for any other remedies that may


                                     -14-


<PAGE>


be available to the party serving such notice against the party in default,
and any termination in the exercise of such right shall not relieve either
party from any obligations accrued to the date of such termination or relieve
the party in default from liability in damages to the other for breach of this
Agreement. Waiver by either party of a single default or a succession of
defaults shall not deprive such party of any right to terminate this
Agreement, or to have recourse to arbitration, arising by reason of any
subsequent default.

         (3) Any delays or failure by either party hereto in the performance
hereunder shall be excused if and to the extent caused by occurrences beyond
such party's control, including, but not limited to, acts of God, strikes or
other labor disturbances, war, sabotage, and any other cause or causes,
whether similar or dissimilar to those herein specified which cannot be
controlled by such party.

         (4) In the event that further lawful performance of this Agreement or
any part hereof shall be rendered impossible by the entry of a final judgment
or final order in an antitrust or trade regulation case by any court,
commission or agency having jurisdiction over either party, or a parent
company of either party, whether or not the entry of such judgment shall be
consented to by such party or by such parent company, the parties covenant and
agree, that forthwith upon the entry of such final judgment or


                                     -15-


<PAGE>


final order, they will exert their best efforts to agree on an amendment or
amendments to this Agreement or on modifications of their practices hereunder
in such manner as will fully comply with said final judgment or final order.
In the event that either party shall receive a formal charge, indictment, or
complaint which might lead to the entry of such a final judgment or final
order, such party shall promptly notify the other party of such fact and
afford an opportunity to such other party for consultation regarding the
matter. In the event that the parties are unable, within a period of six (6)
months after written notice by either party to the other of such impossibility
of lawful performance, to reach such agreement, either party may terminate
this Agreement by written notice to the other party effective as of the
expiration of such six (6) month period. All rights or obligations of either
party under this Agreement or the portion thereof adjudged invalid by such
final judgment or final order shall be suspended upon the entry thereof pending
negotiations between the parties as herein provided to remedy such invalidity.

         (5) Upon termination of this Agreement pursuant to Paragraph (1) or
(4) of this Article, CRJ shall, unless the parties hereto otherwise agree in
writing, be dissolved and liquidated and the net proceeds thereof divided and
distributed among its shareholders as promptly and reasonably as possible in
accordance with respective stock


                                     -16-


<PAGE>


interests in CRJ. Nothing herein, however, shall be deemed to require the
dissolution and/or liquidation of CRJ in the event that either party should
acquire all of the shares of CRJ.

         (6) Upon termination of this Agreement pursuant to Paragraph (2) of
this Article, the party terminating this Agreement shall have the option
either

         (a) to demand dissolution and liquidation of CRJ; or

         (b) to purchase all of the shares of CRJ then held by the other party
            at the price per share equal to the then book value per share of
            CRJ.

         The parties agree that upon the exercise of either option, all
obligations of the parties under this Agreement, other than those arising from
the ordinary course of business dealings among CRJ, AJI and CRBL, shall
terminate.


                                  ARTICLE XI
                                    TAXES

         (1) All income taxes required by the laws of Japan to be withheld
from any payment to be made to CRBL pursuant to this Agreement shall be for
the account of CRBL.

         (2) AJI agrees to furnish or to cause CRJ to furnish to CRBL official
tax receipts or other evidence issued by the Japanese tax authorities together
with English translation thereof sufficient to enable CRBL to establish
payment of the taxes described in Paragraph (1) above.


                                     -17-


<PAGE>


                                 ARTICLE XII
                                   EXPENSES

         Except as otherwise provided in this Agreement, each party hereto
shall bear its own expenses relating to this Agreement and the performance
thereof.


                                 ARTICLE XIII
                                  DISCLAIMER

         Neither of the parties hereto, nor CRJ shall be deemed to represent
the other party or to have the authority to represent the other party or its
subsidiaries in any way whatsoever except as specifically agreed to by such
other party in writing. This Agreement shall not constitute either of the
parties hereto or CRJ to be the agent or representative of the party in any
way whatsoever.


                                 ARTICLE XIV
                                ARTICLE TITLES

         The headings to the articles of this Agreement have been inserted
only to facilitate reference and shall not be taken as being of any
significance whatsoever in the construction or interpretation of this
Agreement.


                                  ARTICLE XV
                                 SEVERABILITY

         Subject to the provisions of Paragraph (4) of Article X, if any term
or provision of this Agreement shall hereafter be finally determined to be not
enforceable or void as


                                     -18-


<PAGE>


against public policy or otherwise legally unenforceable, the same shall be
severable from and eliminated from the balance of this Agreement and the
balance of this Agreement shall continue in force as the Agreement of the
parties notwithstanding that determination, unless such unenforceable terms or
provisions shall be so significant as to materially affect the parties'
expectations regarding this Agreement.


                                  ARTICLE XVI
                              MULTIPLE ORIGINALS

         This Agreement shall be executed in four counterparts, two being in
the English language and two being in the Japanese language, each of which
counterparts shall be deemed an original. In the event of any discrepancy or
difference between the English and Japanese versions, the English version
shall prevail in all respects.


                                 ARTICLE XVII
                                   NOTICES

         (1) All notices, requests, demands and other communications under
this Agreement or in connection herewith shall be given to or made upon the
respective parties as follows:

         TO:   AJINOMOTO CO., INC.
               President
               5-8, Kyobashi, 1-chome
               Chuo-ku, Tokyo
               Japan

                                     -19-


<PAGE>


         TO:   THE CHARLES RIVER BREEDING LABORATORIES, INC.
               President
               251 Ballardvale Street
               Wilmington, Massachusetts 01887
               U.S.A.

         (2) All notices, requests, demands and other communications given or
made in accordance with the provisions of this Agreement shall be in writing,
and shall be telexed and later confirmed by registered airmail. The
communication shall be deemed to be given or made when telex is received or
when mail is deposited in the United States or Japanese mail, as the case may
be, postage prepaid.

         (3) Any party may alter its address above set forth by notice in
writing to the other party hereto, and such notice shall be considered to have
been given ten (10) days after the airmailing thereof.


                                ARTICLE XVIII
                                GOVERNING LAW

         This Agreement shall be governed by and interpreted in accordance
with the laws of Japan.


                                 ARTICLE XIX
                          MODIFICATION OF AGREEMENT

         No oral explanation or oral information by either party hereto shall
alter the meaning or interpretation of this Agreement. No modification or
amendment of the terms of this Agreement or any Exhibit attached hereto, and
no waiver of any of the terms or conditions hereof or thereof shall be


                                     -20-


<PAGE>


valid unless made in writing duly executed by the parties hereto or thereto,
and further unless made after obtaining validation or approval of the Japanese
Government if such validation or approval is required by Japanese law for such
writing at the time the parties execute it.


                                  ARTICLE XX
                               ENTIRE AGREEMENT

         This Agreement (together with the Schedules annexed hereto which are
hereby incorporated by reference) constitutes the entire agreement of the
parties and supersedes any prior agreements or understandings with the
exception of the License and Technical Assistance Agreement and Tradename and
Trademark License Agreement among CRBL, CRJ and AJI dated March 24, 1978.

         IN WITNESS WHEREOF, the parties hereto have caused this Agreement to
be executed by their duly authorized representatives on the day and year first
set forth above.


                                           AJINOMOTO CO., INC.

                                           By
                                             -----------------------------------

                                           THE CHARLES RIVER BREEDING
                                             LABORATORIES, INC.

                                           By
                                             -----------------------------------


                                     -21-


<PAGE>


                                  SCHEDULE A
                                  TERRITORY

         Afghanistan, Bangladesh, Burma, Cambodia, Sri Lanka, People's
Republic of China and Republic of China, Hong Kong, Indonesia, Japan, Republic
of Korea, Democratic People's Republic of Korea, Laos, Malaysia, People's
Republic of Mongolia, Pakistan, Republic of Philippines, Singapore, Thailand
and The Socialist Republic of Viet-Nam.


                                     -22-


<PAGE>


                                  SCHEDULE B
                                    REPORTS

1) Weekly sales and production results.
2) Monthly sales results, report on number of animals produced and shipped,
estimate of net income.
3) Quarterly sales results, P&L statement, report on number of animals produced
and shipped, balance sheet, key expense summary, analysis of general production
expense, analysis of general and administrative expenses, analysis of delivery
expense/(income), report on capital expenditures (only during periods of
expansion).
4) Annual average manpower analysis by job classification and analysis of
employee payroll rates.


                                     -23-
<PAGE>
                             AMENDMENT AGREEMENT


THIS AGREEMENT, made and entered this 2nd day of December 1982 by and among THE
CHARLES RIVER BREEDING LABORATORIES, INC., CHARLES RIVER JAPAN, INC. and
AJINOMOTO CO., INC.

                                  WITNESSETH:

WHEREAS, the parties hereto entered into License and Technical Assistance
Agreement and Tradename and Trademark License Agreement dated March 24, 1978
which was amended by Amendment Agreement dated the 19th day of October, 1978
(as so amended, hereinafter called "the License Agreement"),

WHEREAS, the parties hereto have agreed to make certain changes to Paragraph
(1) of Article XI CONSIDERATION, of the License Agreement,

NOW, THEREFORE, in consideration of the premises and of the mutual agreement
hereinafter contained, the parties hereto agree as follows:

1. Paragraph (1) of Article XI CONSIDERATION, of the License Agreement is
hereby amended to read as follows.

(1)  In consideration for the rights granted to it pursuant to Article II, III,
     V and VI of this Agreement, CRJ shall pay to CRBL the following royalties
     and/or fees:

     A.   Three percent (3%) of the net sales price of rats and mice of the
          PRODUCTS sold by CRJ and its sublicensees. Provided, however, that if
          the annual pre-tax net profit on sales of such rats and mice of CRJ
          is ten percent (10%) or more in the fiscal year ending on March 31,
          1986, the royalty shall continue at three percent (3%) for the
          succeeding fiscal year; if such annual pre-tax net profit on sales of
          CRJ is less than ten percent (10%) in the fiscal year ending on March
          31, 1986 the royalty shall be two percent (2%) for the succeeding
          fiscal year; after the close of each fiscal year thereafter until the
          expiration of the license with respect to LABORATORY ANIMALS which
          are rats and mice a similar review shall occur and the royalty rate
          shall be established for the succeeding fiscal year at either three
          percent (3%) or two percent (2%).

     B.   Three percent (3%) of the net sales price of each species of
          LABORATORY ANIMALS other than rats and mice sold by CRJ



<PAGE>


          and its sublicensees from the date of the initial sale in commercial
          quantities of each such species bred by CRJ or its sublicensees until
          the expiration of a period consisting of ten (10) full fiscal years
          of CRJ, which period commences on the first day of the corporate
          fiscal year which falls on or immediately follows the date of such
          initial sale; provided, however, that the same annual review as for
          rats and mice shall be performed with respect to each separate
          species to determine the royalty rate (be it two percent (2%) or
          three percent (3%) for the eleventh (11th) and subsequent fiscal
          years.

     C.   Three percent (3%) of the net sales price of FEED FOR LABORATORY
          ANIMALS and EQUIPMENT manufactured and sold by CRJ and its
          sublicensees under TECHNICAL INFORMATION heretofore supplied and/or
          future TECHNICAL INFORMATION to be supplied on or before June 30,
          1982, provided that such royalty shall cease to be payable after June
          30, 1982 with respect to the Products referred to above. Provided
          further that if any new TECHNICAL INFORMATION with respect to FEED
          FOR LABORATORY ANIMALS and EQUIPMENT is supplied after June 30, 1982,
          the royalty applicable to FEED FOR LABORATORY ANIMALS and EQUIPMENT
          manufactured thereafter using such new TECHNICAL INFORMATION shall be
          agreed upon between CRBL and CRJ on a case by case basis.

     D.   Three percent (3%) of all engineering or professional fees which CRJ
          and its sublicensees receive with respect to the sublicense,
          rendering of services or other authorized dissemination of TECHNICAL
          INFORMATION in connection with EQUIPMENT not resulting in the sale of
          the PRODUCTS or which are not measured by sale of the PRODUCTS.

2. The amendment set forth above shall be subject to the necessary
authorization by the Japanese Government under the Foreign Exchange and Foreign
Trade Control Law and shall become effective when such authorization is
granted.





                                       2

<PAGE>


IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
executed by their duly authorized representatives on the day and year first
above written.

                                    THE CHARLES RIVER BREEDING
                                    LABORATORIES, INC.


                                    By
                                      ------------------------------------------
                                            Henry L. Foster, President


                                    AJINOMOTO CO., INC.


                                    By
                                      ------------------------------------------
                                            Katsuhiro Utada, President


                                    CHARLES RIVER JAPAN, INC.


                                    By
                                      ------------------------------------------
                                            Tamio Itoh, President




                                       3
<PAGE>

                              AMENDMENT AGREEMENT


     THIS AGREEMENT, made this 19 day of October 1978 by and between THE
CHARLES RIVER BREEDING LABORATORIES, INC.(hereinafter called "CRBL"), CHARLES
RIVER JAPAN, INC.(hereinafter called "CRJ") and AJINOMOTO CO., INC.(hereinafter
called "AJINOMOTO")

                                  WITNESSETH:

     WHEREAS, CRBL, CRJ, and AJINOMOTO entered into the License and Technical
Assistance Agreement and Tradename and Trademark License Agreement dated March
24,1978 (hereinafter called the "License Agreement");

     WHEREAS, thereafter the Japanese Fair Trade Commission indicated that
certain provisions of the License Agreement are in violation of the Japanese
Law relating to Prohibition of Private Monopoly and Methods of Preserving Fair
Trade, and requested that such provisions be either deleted or amended so as to
be in accord with the said Law; and

     WHEREAS, CRBL, CRJ, and AJINOMOTO are willing to amend such provisions of
the License Agreement as hereinafter provided.

     NOW, THEREFORE, the parties hereto hereby agree as follows:

     1. Paragraph (1) of Article IV of the License Agreement is hereby amended
by deleting the words "and for two (2) years thereafter" in line 4 thereof so
that said Paragraph (1) will read as follows:

          "(1) CRBL hereby covenants that it shall not utilize or
license others to utilize the TECHNICAL INFORMATION for the purpose of
breeding, use or sale of the PRODUCTS in the TERRITORY during the term of this
Agreement, provided that the term of this Agreement with respect to TECHNICAL
INFORMATION concerning a particular species shall be that period during which
royalties are paid with respect to such species; if royalties never become
payable with respect to a particular species, CRBL's covenant against
utilization and licensing of such species shall cease at the time any such
species is no longer subject to the licensing provisions of this Agreement."

     2. Paragraph (2) of Article X of the License Agreement is hereby amended
by deleting the word "perpetual" in line 3 thereof and inserting an additional
proviso at the end thereof so that said Paragraph (2) will read as follows:




<PAGE>


          "(2) Solely in consideration for the covenants and rights
granted to it by CRBL in Paragraph (1) of this Article X, CRJ hereby grants
CRBL the worldwide, nonexclusive right to use all improvements, discoveries,
inventions and modifications made or developed by CRJ or its sublicensees or
any person manufacturing the PRODUCTS for or on behalf of CRJ relating to the
TECHNICAL INFORMATION and PRODUCTS; provided that during the exclusive period
provided for in Paragraph (1) of Article II, CRBL agrees not to use within the
TERRITORY any such improvements, discoveries, inventions and modifications;
provided, further, that if this Agreement is terminated pursuant to the
provisions of Paragraphs (2) (where breach is that of CRJ) or (5) of Article
XVI hereof, CRBL shall continue to have the non-exclusive right to use such
improvements, discoveries, inventions and modifications after the termination."

     3. Paragraph (1) of Article XVIII of the License Agreement is hereby
amended by replacing the words "(where breach is that of CRBL), (4) or (5) of
Article XVI hereof" in line 6 thereof with the words "(where CRBL fails to
fulfill its material obligation under this Agreement with the intention to
terminate this Agreement) of Article XVI hereof" so that said Paragraph (1)
will read as follows:

          "(1) In order to foster and promote the attainment of the
aims and objectives of CRJ, CRBL agrees that during the term of this Agreement
and for a period of two years after this Agreement or any license of TECHNICAL
INFORMATION hereunder with respect to a particular species is terminated in
accordance with Paragraph (2) (where CRBL fails to fulfill its material
obligation under this Agreement with the intention to terminate this Agreement)
of Article XVI hereof, CRBL shall not, directly or indirectly (through a firm,
joint venture, company or business owned or controlled by it or otherwise),
except through CRJ, engage in the business in the TERRITORY to produce
laboratory animals and/or feed for laboratory animals and/or equipment which
are reasonably competitive with the PRODUCTS or shall not acquire in the
TERRITORY an interest in any firm or business organization producing, selling,
promoting or dealing in laboratory animals and/or feed for laboratory animals
and/or equipment which are reasonably competitive with the PRODUCTS."

     4. Paragraph (2) of Article XVIII of the License Agreement is hereby
amended by replacing the words "(where the breach is that of CRJ) of Article
XVI hereof" in lines 4 and 5 thereof with the words "(where CRJ fails to
fulfill its material obligation under this Agreement with the intention to
terminate this Agreement) of Article XVI hereof" so that said Paragraph (2)
will read as follows:

          "(2) In order to promote fairness and appropriateness and the
attainment of objectives of CRBL, CRJ agrees that for a period of two (2) years
following the termination of this Agreement in accordance with the provisions
of



                                       2

<PAGE>


Paragraph (2) (where CRJ fails to fulfill its material obligation under this
Agreement with the intention to terminate this Agreement) of Article XVI
hereof, CRJ shall not, directly or indirectly, (through a firm, joint venture,
company or business owned or controlled by it or otherwise) engage in the
business in the TERRITORY of producing any laboratory animals or any food for
laboratory animals or any equipment which is reasonably competitive with the
PRODUCTS and shall not acquire in the TERRITORY any interest in any firm or
business organization producing, selling, promoting or dealing in any such
laboratory animals and/or feed for laboratory animals or equipment which are
reasonably competitive with the PRODUCTS."

     5. The amendments set forth above shall be subject to the necessary
validation by the Japanese Government under the Law concerning Foreign
Investment and shall become effective when such validation is granted.

     IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
executed by their duly authorized representatives on the day and year first
above written.



                               THE CHARLES RIVER BREEDING
                               LABORATORIES, INC.


                               By
                                 -----------------------------------------------



                               CHARLES RIVER JAPAN, INC.


                               By
                                 -----------------------------------------------



                               AJINOMOTO CO., INC.


                               By
                                 -----------------------------------------------





                                       3

<PAGE>




                              AJINOMOTO CO., INC.

                       15- 1. KYOBASHI ITCHOME CHUO-KU.
                               TOKYO 104, JAPAN

                                                              January 17, 1994

Mr. James C. Foster
President
The Charles River Laboratories, Inc.
251 Ballardvale street
Wilmington, Massachusetts 01887
U.S.A.


VIA AIRMAIL

                   Re: Amendment of JOINT VENTURE AGREEMENT

  Dear Sir:

         AS you may already be aware, the Japanese Stock Corporation Law and
supplemental laws thereof have been amended effective as of the 1st day of
October, 1993. Under the laws as amended, corporations with stated capital
exceeding 500,000,000 Japanese yen shall have at least three (3) auditors, the
term of office of whom shall be three (3) years.

         Such corporations falling within the abovementioned category which
currently have only two (2) auditors are required to increase the number of
auditors to at least three (3) by the end of the general meeting of
shareholders to settle the first accounting period the end of which arrives
after October 1, 1993. Therefore, it in necessary for Charles River Japan,
Inc. ("CRJ") to increase its auditors from two (2) to three (3) or more by the
end of the ordinary general meeting of shareholders to be held in June, 1994.

         Accordingly, we would like to propose amending Article II Paragraph
(5) of the JOINT VENTURE AGREEMENT with respect to CRJ dated the 24th day of
June, 1981 (the "JVA" to read as follows:

        "The parties hereto agree that they will vote their shares of CRJ in
         such manner that at all times during the effective period of this
         Agreement there shall be three statutory auditors (Kansayaku) of
         CRJ; one to be a person designated by AJI, one to be a person
         designated by CRL, and one to be a person designated by agreement
         between AJI and CRL.

         Taking this opportunity, we would also like to amend certain parts of
the JVA as set forth below.

         (a)   All references to "THE CHARLES RIVER BREEDING
               LABORATORIES, INC." in the JVA shall be amended to read
               "THE CHARLES RIVER, LABORATORIES, INC.", and all references

                                     -1-


<PAGE>



AJINOMOTO CO., INC.


               to "CRBL" in the JVA shall be amended to read "CRL".

         (b)   CRL and AJI have agreed, at the ordinary general meeting of
               shareholders of CRJ held this June, to increase the number of
               directors of CRJ from ten to twelve, and have casted their
               votes as shareholders of CRJ at such meeting in such manner
               that the two persons designated by CRL and AJI, respectively,
               be appointed as directors of CRJ. Accordingly, Article II,
               Paragraph (1) shall be amended to read as follows:

               "CRJ has a Board of Directors consisting of twelve directors.
               The parties hereto agree that they will cast their votes as
               shareholders of CRJ in such manner that the Board of Directors
               shall consist of an equal number of persons designated by AJI
               and CRL."

         (c)   The address of our company provided for in Article XVII,
               Paragraph (1) shall be amended to read as follows:

        "TO:   AJINOMOTO CO., INC.
               President
               15-1, Kyobashi itchome
               Chuo-ku, Tokyo
               Japan"

         If the foregoing is acceptable, please sign and return one original of
this letter.

                                            Very truly yours,

                                            Ajinomoto Co., Inc.

                                            ------------------------------------
                                            President

         Agreed and accepted.


                                            The Charles River Laboratories, Inc.

                                            ------------------------------------
                                            President


                                            (Date)
                                            ------------------------------------

                                      -2-


<PAGE>




                                   ADDENDUM

         This ADDENDUM made and entered into as of August 30, 1996 by and
between The Charles River Laboratories, Inc., a corporation organized and
existing under the laws of Delaware, having its principal place of business at
251 Ballardvale Street, Wilmington, Massachusetts 01887, the United States of
America (hereinafter referred to as "CRL") and Ajinomoto Co., Inc., a
corporation organized and existing under the laws of Japan, having its
principal place of business at 15-1, Kyobashi 1 chome, Chuo-ku, Tokyo 104,
Japan (hereinafter referred to as "Ajico")


                                  WITNESSETH:

         WHEREAS, the parties hereto have entered into a Joint Venture
Agreement dated June 24, 1981, as amended an June 15, 1987 and an January 17,
1994 (as so amended, hereinafter referred to as "Original Agreement') for the
production of laboratory animals and/or feed for laboratory animals; and

         WHEREAS, the parties hereto have been engaged in the production of
laboratory animals and feed for laboratory animals through Charles River
Japan, Inc. (hereinafter referred to as "CRJ") in Japan; and

         WHEREAS, CRL desires to produce and/or sell laboratory animals and
feed for laboratory animals through a joint venture company to be established
with The Shanghai No. 1 Biochemical & Pharmaceutical Company of China in the
People's Republic of China; and

         WHEREAS, CRL and Ajico agreed to exclude the People's Republic of
China from the territory for CRJ which was stipulated in the Original
Agreement an the terms and conditions provided in the letter agreement as of
July 12, 1996 sent from Mr. Kazutoshi Yamada, Executive Managing Director of
Ajico and accepted by Mr. James C. Foster, President & CEO of CRL as of July
31, 1996 (hereinafter referred to as "Letter Agreement"),

         NOW, THEREFORE, in consideration of the premises and mutual


<PAGE>



covenants herein contained, both parties hereto agree as follows:

Article 1. (Amendment to the Joint Venture Agreement).

         Schedule A attached to the Original Agreement shall be amended by
eliminating "the People's Republic of China" therefrom.

Article 2. (Payment of the Compensation)

         As the compensation for CRJ's giving up of the exclusive territory of
the People's Republic of China, CRL shall pay CRJ three percent (3%) of the
net sales of laboratory animal and feed therefor made in, to or from the
People's Republic of China by CRL, or any third party in which CRL has,
directly or indirectly, share of interest or any third party with which CRL
has a cooperative arrangement therefor including, but not limited to,
licensing arrangement and distribution arrangement (such third party shall be
hereinafter collectively referred to as "CRL Partner").

         For the purpose of this Article 2 "net sales" means an aggregate
amount of gross invoice price less only commercial, trade or cash discounts
and adjustments actually allowed to customers.

         Payment of the Compensation provided for above shall be made to CRJ
quarterly within three (3) months after the end of each fiscal quarter of CRL.
The payment to CRJ after deducting any withholding tax applicable, unless
otherwise instructed by CRJ, shall be made in Japanese currency at the
exchange rate of Citybank N.A., New York, Now York the United States
prevailing on the date of payment. All such exchange charges shall be borne by
CRL.

         CRL shall maintain, or shall cause CRL Partner to maintain, adequate
records so that the net sales can be determined.

         CRL shall render to CRJ within three (3) months after the end of each
fiscal year of CRL, a statement of sales separately stating sales of
laboratory animals by species, feed for laboratory animals for the preceding
fiscal year of CRL; such statement shall be certified as accurate by an
independent public accountant.

Article 3. (Exportation)

         CRL or CRL Partner may export laboratory animals and feed therefor
produced in the People's Republic of China to Japan and Korea an condition
that CRJ is appointed as the sole and exclusive importer of such laboratory
animals and


<PAGE>



feed therefor within the territory of Japan and Korea. The details of the
terms and conditions for such exclusive importation of the laboratory animals
will be provided in an Exclusive Exportation Agreement to be separately
negotiated and entered into by CRJ and CRL or CRL Partner. CRL and Ajico
hereby confirm that the preceding provision shall in no way affect the status
of Japan and Korea as a part of the territory reserved exclusively for CRJ as
specified in Schedule A of the Original Agreement (as amended pursuant to
Article 1 hereon, and therefore, the export to Japan and Korea as well as
other countries in the territory shall be subject to the control of CRJ.

Article 4. (Term)

         This ADDENDUM shall become effective as of August 30, 1996 and shall
continue in full force and effect as long as the Original Agreement remains
effective.

         IN WITNESS WHEREOF, the parties hereto have caused this ADDENDUM to
be signed by their respective duly authorized representatives on the date
first above written

                                           The Charles River Laboratories, Inc.

                                           /s/ James C. Foster
                                           -------------------------------------
                                           James C. Foster
                                           President and Chief Executive Officer
                                           Date: Oct. 2, 1996
                                                 -------------------------------


                                           Ajinomoto Co., Inc.

                                           /s/ Shunsuke Inamori
                                           -------------------------------------
                                           Shunsuke Inamori
                                           President
                                           Date: September 26, 1996
                                                 -------------------------------





<PAGE>


                                       ORIGINAL FILED IN ORIGINAL DOCUMENTS FILE


                      [Letterhead of Ajinomoto Co., Inc.]


                                                               October 25, 1978

Mr. James C. Foster
Charles River
Breeding Laboratories
251 Bllardvale St.
Wilmington, Massachusetts
U. S. A.

Dear Mr. Foster,

     Kindly find enclosed original of Amendment Agreement duly signed by all
the parties concerned.

Please be advised that the Agreement was accepted by our Fair Trade Commission
on October 20, and approved by The Bank of Japan on October 25.

     Thanking you for your cooperation on this matter, with best wishes,


                                                Very truly yours,


                                                Ajinomoto Co., Inc.


                                                ---------------------------
                                                Izumi Hayashi
                                                Director of Patents & Licensing

Enc. Amendment Agreement (Original)

<PAGE>
                            MEMORANDUM OF AGREEMENT


     THIS MEMORANDUM OF AGREEMENT, made this 24th day of March, 1978, by and
among The Charles River Breeding Laboratories, Inc. ("CRBL"), Ajinomoto Co.,
Inc. ("Ajinomoto"), Charles River Japan, Inc. having its principal office at
15-1, Takara-cho 1-chome, Chuo-ku, Tokyo, Japan ("Old CRJ") and Charles River
Japan, Inc. having its principal office at 858, Onna, Atsugi-shi, Kanagawa-ken,
Japan ("New CRJ").

                                  WITNESSETH:

     WHEREAS, Ajinomoto has proposed that Old CRJ be dissolved and liquidated
as of the date hereof and transfer all its business and assets to New CRJ which
has been established as a wholly-owned subsidiary of Ajinomoto as of the date
hereof, that the License and Technical Assistance Agreement and Tradename and
Trademark License Agreement between CRBL and Old CRJ dated October 28, 1974 be
terminated as of the date hereof and that a new License and Technical
Assistance Agreement and Tradename and Trademark License Agreement having
substantially the same provisions be executed between CRBL and New CRJ as of
the date hereof; and

     WHEREAS, CRBL is willing to accept the above-mentioned proposal of
Ajinomoto;

     NOW, THEREFORE, the parties hereto hereby agree as follows:

     1. The License and Technical Assistance Agreement and Tradename and
Trademark License Agreement between CRBL and Old CRJ dated October 28, 1974
("Old License Agreement"), together with the guarantee by Ajinomoto of Old
CRJ's obligations thereunder, shall be and is hereby terminated as of the date
hereof and shall cease to have any further effect except as expressly specified
therein.

     2. The Letter Agreement among CRBL, Old CRJ and Ajinomoto dated February
4, 1977 shall be and is hereby cancelled as of the date hereof, and all the
royalty payments deferred pursuant to the said Letter Agreement shall be paid
together with interest set forth therein within thirty (30) days after the date
of the necessary approval thereof by the Japanese Government.

     3. CRBL and New CRJ are this date entering into a new License and
Technical Assistance Agreement and Tradename and Trademark License Agreement
("New License Agreement"), and CRBL hereby approves and agrees




<PAGE>


that Old CRJ may disclose to New CRJ for use by New CRJ under the New License
Agreement any and all of the Technical Information which CRBL has disclosed to
Old CRJ pursuant to the Old License Agreement.

     4. The Termination Agreement between Ajinomoto and CRBL dated August 15,
1974 as amended on August 28, 1975 shall be and is hereby cancelled as of the
date hereof and shall have no further effect; provided, however, that Ajinomoto
hereby agrees with CRBL as follows:

     (1) In case Ajinomoto desires to sell any part of shares in New CRJ during
     the effective term of the New License Agreement, it must first offer such
     shares to CRBL at the same bona fide price offered by third party. If CRBL
     does not agree to purchase such shares at such price within sixty (60)
     days after receipt of Ajinomoto's notice of its desire to sell such
     shares, Ajinomoto may within ninety (90) days thereafter sell such shares
     at such price to such third party. Any such buyer shall be bound by the
     same agreements as Ajinomoto under this Memorandum of Agreement.

     (2) Ajinomoto agrees for itself and for its affiliates that so long as it
     has a controlling interest in New CRJ or business to be operated by New
     CRJ under the New License Agreement, it will not, directly or indirectly
     (through a firm, joint venture, company or business owned or controlled by
     it or otherwise), except through New CRJ, engage in the business in the
     Territory (as defined in the New License Agreement) to produce Laboratory
     Animals and/or Feed specially formulated for Laboratory Animals and/or
     Equipment which are reasonably competitive with the Products (as defined
     in the New License Agreement) or shall not acquire in the Territory an
     interest in any firm or business organization (other than New CRJ)
     producing, selling, promoting or dealing in laboratory animals and/or feed
     for laboratory animals and/or equipment which are reasonably competitive
     with the Products.

     (3) Ajinomoto agrees for itself and for its affiliates that it will
     maintain in strict confidence and will not make any unauthorized use or
     disclosure of Technical Information (as defined in the New License
     Agreement) and other confidential technical, economic and marketing
     information received from CRBL, Old CRJ and/or New CRJ, as the case may
     be, so long as and to the extent that such Technical Information or such
     other information remain unpublished; provided, however, that nothing
     herein shall prevent disclosure or use of such Technical Information or
     such other information which was known to the recipient at the time of
     disclosure, or which are properly obtained by the recipient from some
     source other than, directly or indirectly from CRBL, Old CRJ or New CRJ,
     as the case may be.



                                       2

<PAGE>


     IN WITNESS WHEREOF, the parties hereto have caused this instrument to be
executed by their duly authorized representatives on the date and year first
above written.


                          The Charles River Breeding Laboratories, Inc. ("CRBL")




                          ------------------------------------------------------



                          Ajinomoto Co., Inc. ("Ajinomoto")




                          ------------------------------------------------------



                          Charles River Japan, Inc. ("Old CRJ")




                          ------------------------------------------------------



                          Charles River Japan, Inc. ("New CRJ")




                          ------------------------------------------------------




                                       3
<PAGE>
                                                                         ANNEX 1


                             LIST OF THE BUILDINGS


     ITEM            NAME OF BUILDING                         SQUARE(M2)
   -----------------------------------------------------------------------
      1              Synthetic Building                          1,800
      2              Air-Condition Room                            40
      3              Acid Soaking Room                             5
      4              Human Waste Treatment Pool                   16.4
      5              Water Pool                                    20
      6              Cement Road                                   953
      7              Cement Drainpipes                            108m
      8              Cement Drainpipes                            36m
      9              Iron Railing                                 269m
      10             Stone Wall                                   54m
      11             Pools & Flower Beds
      12             Park Shed                                     72
      13             Tree-planting                               3,000






                                       2

<PAGE>


                                                                         ANNEX 2






                                       3

<PAGE>


                            ASSET TRANSFER AGREEMENT

THIS AGREEMENT is entered into on this 1st day of Sept. 1997 by and between
Zhanjiang Scientific & Technical Service Centre, Guangdong, the People's
Republic of China and Zhanjiang A & C Biological Ltd., Guangdong, the People's
Republic of China.

                             PRELIMINARY STATEMENT

This Agreement is entered into in accordance with Clause 6.5 of the Joint
Venture Contract dated [ ] ("the JV-Contract") by and between Zhanjiang
Scientific & Technical Service Centre of China, ("Party A") and Charles Rivers
Laboratories Inc., of the United States of American, ("Party B"). In accordance
with the JV-Contract, Zhanjiang Scientific & Technical Service Centre shall
sell certain assets to the Zhanjiang A & C Biological Ltd.

                            ARTICLE I - DEFINITIONS

The following terms used in this Agreement shall have the following meanings:

     1.1  "Associated Company" means any company or organisation which is under
          common ownership or control as one of the parties to this Agreement.

          "Consideration" means that amount described in Clause 3 of this
          Agreement

          "Effective Date" means the date upon which Party B receives it's
          Investment Certificate, in accordance with Clause 5.5 of the
          JV-Contract, for its capital contribution to the Purchaser.

          "Appraisal Report" means the financial audit carried out by the
          Zhanjiang Asset Appraisal Corporation on 10 April 1996.

          "Investment Certificate" means the investment certificate(s) referred
          to in Clause 5.5 of the JV-Contract.

          "Price Waterhouse Report" means the financial report carried out by
          Price Waterhouse the international firm of accountants on 12
          September 1996.

          "Products" means any Tachypleus Amebocyte Lysate products.





                                       4

<PAGE>


          "Purchaser" means the new Sino-foreign joint venture company called
          Zhanjiang A & C Biological Ltd registered in Zhanjiang Guangdong,
          whose legal address is 38 Middle of People Avenue, Zhanjiang,
          Guangdong, Peoples republic of China.

          "Sale Assets" means the plant and machinery set out in Schedule I to
          this Agreement.

          "Trade-Know How" means all the knowledge and know-how developed and
          used by the Vendor, Zhanjiang Sino-American Biological Ltd. or any
          Associated Company of either in manufacturing Products in China
          including but not limited to business and governmental contacts and
          connections;

          "Vendor" means Zhanjiang Scientific & Technical Service Centre
          registered in Zhanjiang, Guangdong, the Peoples Republic of China and
          with it's legal address at 2 South Road, Nanqiao, Chikan, Zhanjiang,
          Guangdong, the Peoples Republic of China.

                         ARTICLE 2 - SALE AND PURCHASE

2.1  The Vendor as beneficial owner shall sell and the Purchaser, relying upon
     the representations warranties and undertakings of the Vendor contained in
     this Agreement, shall purchase the Sale Assets and Trade-Know How free
     from all forms of security or restrictions of any kind, adverse claims or
     reservations of title and upon the terms of this Agreement. It should be
     noted that in purchasing the Trade Know-How, the Purchaser has properly
     reimbursed the Vendor for the intangibles assets, as valued in the
     Appraisal Report and approved in the Price Waterhouse Report, and no more
     money shall be due to the Vendor in that regard.

                           ARTICLE 3 - CONSIDERATION

3.1  The Consideration for the sale and purchase of the Sale Assets shall be
     the payment in cash of US$789,166, which can be divided into:

     Plant and Machinery        US$311,075
     Trade-Know How             US$478.091
                                ----------
                                US$789,166



                                       5

<PAGE>


3.2  Payment of the Consideration shall be made by the Purchaser to the Vendor
     in two instalments: 3.2.1 The first instalment of USS266,750 shall be made
     on the Effective Date. 3.2.2 The final instalment of USS522,416 shall be
     made at the request of the Vendor, but no sooner than the first day upon
     which both of the Parties have made their full contributions to the
     Purchaser in accordance with Clause 5.2 and 5.3 of the JV-Contract and
     have obtained the relevant Investment Certificates.

                    ARTICLE 4 - WARRANTIES AND UNDERTAKINGS

4.1  The Vendor is or was the only owner of equity in a Sino-foreign equity
     joint venture company called Zhanjiang Sino-American Biological Ltd. ("Old
     JVI").

     4.1.1 The business of the Old JV is in direct competition to that of the
           Purchaser. From the Effective Date, the Vendor undertakes and
           warrants that neither it nor the Old JV nor any Associated Company of
           either will from the Effective Date carry out business which will in
           the reasonable opinion of the Purchaser in any way compete ,with the
           business of the Purchaser.

           The Vendor undertakes and warrants that it's senior representatives,
           Zheng WeiHan and Fen Jujin, shall take on any role for the Purchaser
           as the Purchaser shall request and shall not in any event work for
           any organisation, which in the reasonable opinion of the Purchaser,
           is in competition, whether direct or otherwise with the Purchaser.

4.2  The Vendor further warrants and undertakes that:

     4.2.1 all customers that currently obtain their Products from either the
           Vendor, the Old JV or from any Associated Company shall obtain any
           future Products from the Purchaser.

     4.2.2 all suppliers that currently provide materials used in the
           production of the Products by either the Vendor, the Old JV or any
           Associated Company will be prepared to supply such materials to the
           Purchaser on terms at least as favourable as those previously offered
           to the aforementioned companies.





                                       6

<PAGE>


    4.2.3 neither the Purchaser nor Party B shall in any way be responsible
          for any liabilities of the Vendor, the Old JV or any Associated
          Company.

    4.2.4 the Sale Assets include at least all of the assets in the Appraisal
          Report in the category of Plant and Machinery as approved in the
          Price Waterhouse Report.

    4.2.5 it has the fight and title to the Sale Assets and Trade Know-How
          and has the authority to deal with the Sale Assets and Trade-Know How
          in its entire discretion in accordance with the relevant laws.

    4.2.6 it has obtained all the relevant approvals for the sale of the Sale
          Assets and the Trade-Know How under the terms of this Agreement and
          the value of these items has been valued and verified in accordance
          with the relevant laws.





                                       7

<PAGE>


    4.2.7 the Sale Assets and Trade-Know How represent all the plant and
          machinery and knowledge used by the Vendor and any Associated Company
          of either in its current business with the same business scope as
          that of the Purchaser.

    4.2.8 the Sale Assets and Trade-Know How will put the Purchaser in the
          position to be able to commence it's new business of producing
          Products and carry out the business scope of the Purchaser.

    4.2.9 the Sale Assets and the Trade Know-How shall be transferred to the
          Purchaser in accordance with the law.

                      ARTICLE 5 - RISK PROPERTY AND TITLE

5.1  Risk and property in and title to the Sale Assets and where appropriate
     Trade-

     Know How shall pass to the Purchaser on the Effective Date.

                              ARTICLE 6 - INDEMNITY

6.1  The Vendor hereby undertakes to indemnify and hold harmless the Purchaser
     and Party B from and against any and all losses, costs, liabilities and
     expenses incurred by the Purchaser as a result of any representation
     warranty or undertaking given or made by the Vendor in connection with
     this Agreement proving untrue or misleading. In particular the Vendor
     shall indemnify the Purchaser for any cost it may incur in relation to the
     increase in the Consideration in Clause 3.1

                              ARTICLE 7 - TAXATION

7.1  The Vendor hereby undertakes to indemnify the Purchaser from any taxation
     to which it is liable in purchasing or using the Sale Assets or Trade
     Know-How.

                        ARTICLE 8 - MAINTENANCE OF TRADE
                           CONTRACTS AND CONNECTIONS





                                       8

<PAGE>


8.1  Beginning immediately after the signature hereof and continuing for such
     period as the Purchaser may require, the Vendor shall use its best efforts
     to help the Purchaser to make and foster such personal contacts and
     connections with individuals representing the principal customers and
     suppliers of the Vendor, the Old IV or any Associated Company of either as
     may best enable the Purchaser to build its business.

                             ARTICLE 9 - ASSIGNMENT

9.1  This Agreement may not be assigned by either the Vendor or the Purchaser.

                         ARTICLE 10 - FURTHER ASSURANCE

10.1 The Vendor will do such acts and things and execute such documents as may
     be necessary to vest the Sale Assets and where appropriate the Trade-Know
     How in the Purchaser.

                              ARTICLE 11 - WAIVER

11.1 No waiver by the Purchaser of any of the requirements hereof or of any of
     its rights hereunder shall release the Vendor from fall performance of its
     remaining obligation stated herein.

                         ARTICLE 12 - ENTIRE AGREEMENT

12.1 This Agreement (together with any documents referred to herein)
     constitutes the whole agreement between the Parties hereto relating to its
     subject matter and no variations hereof shall be effective unless made in
     writing and signed by the legal representative of both Parties.

                          ARTICLE 13 - APPLICABLE LAW

13.1 This Agreement shall be subject to and shall be construed in accordance
     with the law of the People's Republic of China.

                        ARTICLE 14 - DISPUTE RESOLUTION




                                       9

<PAGE>


14.1 Any disputes arising from the execution of or in connection with this
     Contract shall be settled through friendly consultations between the
     Parties. In case no settlement can be reached through consultations within
     sixty (60) days after a Party has given notice to the other Party of the
     matter in dispute, the disputes shall be submitted to the China
     International Economic and Trade Arbitration Commission in accordance with
     it's existing rules of arbitration. The arbitration award is final and
     binding upon both parties to this Agreement.





                                       10

<PAGE>


14.2 During the arbitration, this Agreement shall be performed continually by
     the Parties except for matters in dispute, and the arbitration proceedings
     shall not prevent any Party from exercising its right of termination under
     this Contract.

                              ARTICLE 15-LANGUAGE

15.1 This Agreement shall be written in Chinese and English. While both the
     Chinese and English versions are both legal and binding versions, in the
     event of a conflict between the provisions of the two versions, the
     English one shall prevail.

     This Agreement is signed, by the duly authorised representatives of both
     Parties as of the date first before written.

     Vendor: Zhanjiang Scientific & Technical Service Centre
     Authorised Representative:

     Purchaser: Zhanjiang A&C Biological Ltd.
     Authorised Representative:






                                       11

<PAGE>


                                   SCHEDULE I


ITEM                NAME OF THE EQUIPMENT                               QUANTITY
- --------------------------------------------------------------------------------
I                   Centrifuge                                             1
2                   Centrifuge                                             2
3                   High Capacity Refrigerated Centrifuge                  1
4                   Refrigerated Centrifuge                                1
5                   Refrigerated Ultracentrifuge                           1
6                   Centrifuge                                             1
7                   Desk Centrifuge                                        1
8                   Lyophilizer                                            1
9                   Lyophilizer                                            1
10                  Dust Particle Counter                                  1
11                  Ampoules Filling & sealing machine                     1
12                  Aspirator                                              2
13                  Single Pan Balance                                     1
14                  Agitator                                               2
15                  Air Supply Apparatus                                   1
16                  Manual Perfusion Unit                                  1
17                  Vacuum Pump                                            1
18                  Dust Catcher                                           3
19                  Electric Heating Sterilizer                            2
20                  Automatic Pure Water Distiller                         1
21                  Refrigerator                                           2
22                  Vapour Aspirator                                       3
23                  Air Conditioner                                        1





                                       12

<PAGE>


24                  Air Conditioner                                        1
25                  Air Conditioner                                        2
26                  Air Conditioner                                        1
27                  Clean Beach                                            1
28                  Clean Beach                                            1
29                  Clean Beach                                            1
30                  Clean Beach                                            1
31                  Transformer                                            1
32                  Power Distribution Screen Control                      4
33                  Power Distribution Screen Control                      10
34                  Power Distribution System                              1
35                  Power Supply Expense                                   1
36                  Running Water Net Expense                              1
37                  Drainpipe Erection Expense                             1
38                  Exhaust Pipes                                          1
39                  Telephone                                              4
40                  Electric Welding Set                                   1
41                  Refrigerator                                           1
42                  Freezer                                                1
43                  Freezer                                                1
44                  Refrigerator                                           1
45                  Refrigerator                                           1
46                  Refrigerator                                           1
47                  Refrigerator                                           4
48                  Refrigerator                                           1
49                  Refrigerator                                           1





                                       13

<PAGE>


50                  Freezer                                                2
51                  Binocular Microscope                                   1
52                  Liquid Nitrogen Tank                                   2
53                  Ultraviolet Analytical Apparatus                       1
54                  PH Meter                                               2
55                  Filter                                                 2
56                  Severing Machine                                       1
57                  Electrophoresis Apparatus                              1
58                  Water Bath Incubator                                   1
59                  TV Set                                                 1
60                  Air Bath Incubator                                     1
61                  Spectrophotometer                                      1
62                  Pump                                                   1
63                  Drill Machine                                          1
64                  Thermostat Cradle                                      1
65                  Ampoules Printer                                       1
66                  Fibre Filter                                           1
67                  Filter                                                 1
68                  Blower                                                 1
69                  Purified System                                        1
70                  Sterilizer                                             1
71                  Oil Boiler                                             1
72                  Accessories for Oil Boiler
73                  Stainless Water Distiller                              1
74                  Super Pure Water Distiller                             1
75                  Air-Condition & Purifying Unit                         1





                                       14

<PAGE>


76                  Air-Condition & Purifying Unit                         1
77                  Air-Condition Tower                                    1
78                  Water Pump                                             1
79                  Water Pump                                             1
80                  Pump                                                   1
81                  Cooling Pipes                                          1
82                  Vapour Sterilizer                                      1
83                  Bottles Washer                                         1
84                  Vials Washer                                           1
85                  Ampoules Dehydrate Machine                             2
86                  Capping Machine                                        2
87                  Diesel Generator                                       1
88                  Filling & sealing machine                              1
89                  Filling & sealing machine                              1
90                  Filling & sealing machine                              1
91                  Generator                                              1
92                  Oven                                                   2
93                  Dryer                                                  1
94                  Dryer                                                  1
95                  Motorcar                                               1
96                  Motorcycle                                             2
97                  Chinese-English Printer                                1
98                  Fax Machine                                            1
99                  Computer Printer                                       1
100                 Enzyme Labelling Analytical Set                        1
101                 PH Meter                                               1





                                       15

<PAGE>


102                 Balance                                                5
103                 Washing Machine                                        1
104                 Ampoules Washer                                        1
105                 TV Antenna Wire Net                                    1
106                 Electric Fan                                           4
107                 Air Exhaust Pipes                                      1
108                 Mosquito Expelling Lamp                                1
109                 Jackscrew                                              1
110                 Shock Driller                                          1
111                 Miccrocoupon                                           1
112                 Balance                                                1
113                 Mixer                                                  1
114                 Pound Machine                                          1
115                 Water Bath Incubator                                   1
116                 Water Bath Incubator                                   1
117                 Sterilizer                                             2
118                 Bowl Sterilizer                                        1
119                 Gas Jar & Gas Stove                                    1
120                 Nitrogen Tank                                          3
121                 Ultrasonic Cell Crushing Apparatus                     1
122                 Shed for Luminous                                      1
123                 Air Conditioner                                        1
124                 Shock Driller                                          1
125                 Oven                                                   1
126                 Centrifuge                                             1
127                 Air Conditioner                                        2





                                       16

<PAGE>


128                 Refrigerator                                           1
129                 Freezer                                                1
130                 PH Meter                                               1
131                 Clean Bench                                            1
132                 Telephone System of Program Control                    1
133                 Disinfection Clamber                                 8.5m2
134                 Water Bath Incubator                                   1
135                 Cement Road                                          300m2







                                       17

<PAGE>


                                                                          ANNEX3






                                       18

<PAGE>


                          TECHNOLOGY LICENSE CONTRACT

THIS CONTRACT is entered into in Zhanjiang, Guangdong, China, on this 1st day
of Sept., 1997 by and between Charles Rivers Laboratories, Incorporated, a 1997
by corporation duly organised and existing under the laws of the United States
of America, whose address for the purposes of this Contract is 251 Ballardvale
Street, Wilmington, Delaware, MA 01887 (hereinafter referred to as "Licensor"),
and Zhanjiang A & C Biological Ltd., a Sino-foreign joint venture registered in
Zhanjiang, Guangdong and whose address for the purpose of this Contract shall
be 38 Middle of People Avenue. Zhanjiang, Guangdong, Peoples Republic of China
(hereinafter referred to as the "Licensee"). They shall be referred to as "the
Parties" to this Contract or as the Party in relation to any one of them.

                             PRELIMINARY STATEMENT

This Contract is entered into in accordance with Chapter 10 of the Joint
Venture Contract dated [ ] by and between Zhanjiang Scientific & Technical
Service Centre of China, and Charles Rivers Laboratories, Incorporated of the
U.S.A. (the "JV-Contract"). As a gesture of good faith by the Licensor, the
Technology licensed under this Contract shall be provided free of charge and at
no cost to the Licensee. The terms in this Contract reflect the Licensor's
gesture.

                            ARTICLE I - DEFINITIONS

The following terms used in this Contract shall have the following meanings:

1.1  "Affiliate" means any company which, through ownership of voting stock or
     otherwise, directly or indirectly, is controlled by, under common control
     with, or in control of, a Party; the term "control" being used in the
     sense of power to elect a majority of directors or to direct the
     management of a company.

1.2  "Approval Authority" means the Ministry of Foreign Trade and Economic
     Cooperation of China or the authority designated by such Ministry to
     approve this Contract.

1.3  "Effective Date" means the effective date of this Contract as defined in
     Article 9.1.

1.4  "Improvements" means any technical improvements or design modifications
     made or acquired by either Party in connection with the Licensed
     Technology.




                                       19

<PAGE>


1.5  "Products" means Tachypleus Amebocyte Lysate products.





                                       20

<PAGE>


1.6  "Licensed Technology' means the technical knowledge which the Licensor
     owns or controls as of the Effective Date and during the term of the
     JV-Contract and has full legal right to transfer or disclose to another
     party, and which pertains to the manufacture of the Products.

1.7  "Supplemental Contracts" shall have the meaning set out for such term in
     Article 4.2 hereof.

1.8  "Technical Documentation" and "Technical Information" means the
     documentation embodying the Licensed Technology, including specifications,
     data, reports and other information that may be reasonably necessary to
     enable the Licensee to establish and carry 'on production of the Products
     and which is owned by Licensor or which Licensor is free to disclose to
     any third party.

                        ARTICLE 2 - RIGHTS AND LICENSES

2.1  (a) Licensor hereby grants to the Licensee:

          (i)  a non-exclusive license to use the Licensed Technology for the
               manufacture of the Products and the provision of related
               services in the People's Republic of China; and

          (ii) a non-exclusive license to market, distribute and sell the
               Products inside and outside the People's Republic of China.

     (b)  his license does not include the right to grant sub-licenses. The
          Licensee shall not assist or permit others to manufacture the
          Products inside or outside the People's Republic of China.

2.2  The Licensee expressly acknowledges and agrees that, other than the rights
     and licenses granted under this Contract, it does not hereby acquire and
     has no right or claim to any other rights in, or to the use of, other
     trademarks, patents, copyright or other industrial property rights or
     technical knowledge owned, used or adopted by Licensor or its Affiliates.

                              ARTICLE 3 - PAYMENT

3.1  No royalty or charge shall be payable by the Licensee for the rights set
     out above.





                                       21

<PAGE>


3.2  The only payments that shall be due under this Contract shall be payable
     where the Licensee has in some way breached the terms hereof In that case
     the Licensee shall indemnify the Licensor for any losses made or damages
     incurred due to the Licensee's breaches.

                    ARTICLE 4 - SCOPE OF TECHNOLOGY SERVICE

4.1  During the term of the JV-Contract, Licensor shall provide to the Licensee
     Technical Information and Licensed Technology related to the Products
     which, as determined by Licensor, in it's sole discretion, may be helpful
     in enabling the Licensee to establish and carry on the production of the
     Products.

4.2  During the term of the N-Contract, the Licensee shall supply to the
     Licensor any Improvements made or obtained by it in connection with the
     Licensed Technology or Products as such become available. With respect to
     Improvements made or obtained by the Licensee these shall be supplied
     substantially in the same form and on the same terms and conditions as
     this Contract. Upon the request by the Licensor, the Licensee shall also
     permit the Licensor to apply in it's own name for patents for Improvements
     of the Licensee and for this purpose shall assign any rights in Q
     Improvements free of charge to the Licensor. In order to obtain the
     continuing benefit of the Licensor's research and development relating to
     the Licensed Technology during the entire term of the Licensee's
     operations, the Licensee agrees that upon the request of Licensor it shall
     execute one or more further technology licenses. The contracts relating to
     the Improvements and the terms for further technology licences by the
     Licensor shall be referred to as the "Supplemental Contracts". (Such
     Supplemental Contracts shall be effective upon approval by the Approval
     Authority.)

                ARTICLE 5 - TECHNICAL COMPLIANCE AND INSPECTION

5.1  The Licensee shall be responsible for maintaining the quality standard of
     the Products it produces, and using the Licensed Technology in accordance
     with the Technical Documentation. If at any time Licensor determines that
     the Licensee is not fulfilling these obligations, Licensor shall notify
     the Licensee of the deficiencies that it believes exist and propose
     methods for correction. The Licensee shall cause the correction to be made
     within sixty (60) days after the said notification.





                                       22

<PAGE>


5.2  Licensor shall be entitled at any time upon reasonable notice being given
     to the Licensee to enter the premises of the Licensee for the purpose of
     inspecting the work being carried out in connection with the Licensed
     Technology and Products.

                              ARTICLE 6 - WARRANTY

6.1  Licensor warrants that as of the Effective Date it will have full legal
     right to transfer and disclose the Licensed Technology to the Licensee and
     that the Licensed Technology is of an advanced level by international
     standard.

6.2  Licensor warrants the accuracy of the specifications included in the
     Technical Documentation.

                          ARTICLE 7 - CONFIDENTIALITY

7.1  All Licensed Technology, advice, and other information ("Confidential
     Information") provided by Licensor pursuant to this Contract shall be kept
     strictly confidential by the Licensee and shall be used solely for its own
     benefit in connection with the manufacture and sale of the Products
     except, however, for such information that must be submitted to
     governmental authorities under Chinese laws and regulations. Such
     information shall be submitted to the governmental authorities only by the
     General Manager of the Licensee. The General Manager shall inform the
     Licensor in writing prior to such submission.

7.2  The Licensee hereby covenants and agrees to keep all such information
     confidential and not, without prior express written consent of Licensor,
     to communicate or allow to be communicated such information to anyone
     except its own employees, and only to such extent as may be necessary for
     the proper performance by such employees of their assigned tasks.

7.3  In order to ensure the observance of Articles 7.1 and 7.2 above by the
     Licensee's employees, the Licensee shall cause each of its employees with
     access to Confidential Information referred to in Articles 7.1 and 7.2
     above to sign a Confidentiality Agreement which protects the Licensor from
     breaches of these obligations by the staff of the Licensee.

7.4  The provisions of Articles 7.1 and 7.2 shall survive the term of this
     Contract for five (5) years.





                                       23

<PAGE>


7.5  The obligations of confidentially, secrecy, non-disclosure and the
     restriction of use contained herein shall not apply to Confidential
     Information which the Licensee can demonstrate; (a) is available to the
     public at the time it is disclosed or thereafter becomes available to the
     public; or

     (b)  is known to the Licensee at the time of disclosure; or

     (c)  properly comes into the possession of the Licensee from an
          independent source.

                     ARTICLE 8 - INFRINGEMENT AND INDEMNITY

8.1  The Licensee acknowledges that Licensor owns or controls and has
     proprietary interest in the Licensed Technology and other Confidential
     Information. The Licensee hereby agrees that, unless otherwise
     specifically provided herein or unless Licensor has consented in writing,
     it will not use or apply in the People's Republic of China for the
     registration of any technology for goods and/or for services similar to
     the Licensed Technology and will not do any act or permit the doing of any
     act which might prevent, directly or indirectly, the registration in the
     People's Republic of China of any patent right with respect to the
     Licensed Technology and other Confidential Information.

8.2  Licensor is not aware of any right of a third party which might be
     infringed through the exercise of the license granted to the Licensee
     hereunder, but Licensor does not warrant nor shall Licensor be liable to
     the Licensee on the ground that any such right of a third party in fact
     exists.

8.3  In the event that any suit, action or other proceeding involving any claim
     of industrial property infringement shall be threatened or instituted
     against the Licensee based upon the Licensee's permitted use hereunder of
     the Licensed Technology or any other Confidential Information, the
     Licensee shall notify Licensor promptly thereof and shall send to Licensor
     copies of any such papers which shall have been served in such suit,
     action or proceeding. Licensor may, if it so elects, control the defense
     of such suit at Licensor's own cost and expense. The Licensee shall have
     the right to be represented by advisory counsel of its own selection at
     its own expense, and shall cooperate fully in the defense of any such
     suit. If Licensor does not elect to control the defense of such suit, the
     Licensee shall undertake such control at the Licensee's own cost and
     expense and Licensor shall




                                       24

<PAGE>


     have the fight to be represented by advisory counsel of its own selection
     and at its own expense. At the request of the Licensee, Licensor shall
     assist the Licensee in the defense of such suit at the Licensee's cost and
     expense.

8.4  The Licensee shall, upon obtaining knowledge of any infringement or
     threatening infringement of Licensor's rights to the Licensed Technology,
     Confidential Information or trademarks owned by Licensor, immediately
     notify Licensor thereof together with al relevant details. Licensor may,
     at its own discretion and cost, prosecute or otherwise stop or prevent
     such actual or threatening infringement in the name of both Licensor and
     the Licensee or either of them, and in each case the Licensee shall render
     all assistance required by Licensor. All amounts received by Licensor in
     connection with any action taken against such infringement pursuant to
     this Article shall be the property of Licensor, if Licensor prosecutes
     such claim, or the property of the party under whose name the prosecution
     is made.

8.5  If Licensor decides not to take any action in respect of any infringement
     or threatened infringement, it shall notify the Licensee of this decision
     within ninety (90) days after receipt of a written notice from the
     Licensee pursuant to Article 8.4 hereof. Upon receipt of Licensor's
     written notice of its decision not to take any action, the Licensee may,
     at its own discretion and cost, prosecute or otherwise stop or prevent
     such actual or threatened infringement in the name of both Licensor and
     the Licensee or either of them. All amounts received by the Licensee in
     connection with any action taken against such infringement pursuant to
     this Article shall be the Party's under whose name the prosecution is
     made, at the reasonable discretion of Licensor.

8.6  The Licensee shall indemnify and hold harmless Licensor from any liability
     for defects in the Products manufactured by or on behalf of the Licensee
     if such defects are, caused by the Licensee's action, inaction, conduct or
     negligence. Licensor shall notify the Licensee of any such claims by a
     third party and the Licensee sqall undertake all responsibilities for such
     action.

8.7  The Licensee and Licensor shall render such assistance reasonably required
     by the other in defense of the claims specified in this Article 8. The
     terms of this Article 8 shall survive the expiration or termination of
     this Contract .





                                       25

<PAGE>


                   ARTICLE 9 - EFFECTIVENESS AND TERMINATION

9.1  Pursuant to Article 4 of the Regulations of the People's Republic of China
     for the Administration of Technology Import Contracts. promulgated on May
     24, 1985, the Licensee shall, within thirty (30) days after the execution
     of this Contract, submit an application to the Approval Authority for the
     examination and approval of this Contract. This Contract is one of the
     ancillary contracts to the JV Contract, and as such the Effective Date
     shall be the first date upon which both of the Parties to the Joint
     Venture have made their capital contributions in full to the Licensee and
     have received their Investment Certificates.

9.2  The Contract Term shall be for the same period as the JV-Contract, thirty
     eight (38) years commencing on the Effective Date. In the event that one
     Party desires to renew this Contract, it shall give written notice of such
     intention to the other Party not later than six (6) months prior to the
     expiry of this Contract. In such case, the Parties shall discuss the
     renewal of this Contract in a constructive manner. Such extension shall be
     effective following approval by the Approval Authority.

9.3  Either Party shall have the fight to terminate this Contract under any of
     the following circumstances:

     (a)  if the other Party commits a material breach of this Contract and
          such breach is not cured within sixty (60) days after written notice
          from the other Party to the Party in breach;

     (b)  the conditions of force majeure prevail for a period in excess of six
          (6) months and the Parties have been unable to find an equitable
          solution pursuant to Article 12;

     (c)  the other Party becomes bankrupt or is the subject of proceedings for
          liquidation or dissolution, or ceases to carry on business or becomes
          unable to pay its debts as they become due; or

     (d)  if the JV-Contract has been terminated.

9.4  Licensor shall have the right to terminate this Contract if Licensor's
     share in the registered capital of the Licensee shall at any time fall
     below eighty percent (80%).

9.5  Termination as set forth above may be effected by the terminating Party
     giving the other Party 30 days' prior written notice specifying the reason




                                       26

<PAGE>


     for such termination and shall become effective upon the expiration of
     such 30 days period.

9.6  Upon termination of this Contract:

     (a)  All moneys accrued, due and payable by one Party to the other Party
          hereunder shall be fully paid within one (1) month, and all Technical
          Documentation shall be returned immediately to Licensor. On no
          account shall such moneys or Technical Documentation be withheld on
          the ground of a dispute arising out of or in relation to this
          Contract or as a set-off against any claim for damages sought to be
          put forward by the Party liable to pay or to return the Technical
          Documentation.

     (b)  The Licensee's right to use the Licensed Technology shall immediately
          cease and the Licensee shall discontinue all use thereof

          The terms of this Article 9.6 shall survive the termination of this
          Contract.

9.7  Except in the case of early termination under Article 9.3 and 9.4 above
     and except with respect to Technical Information and Technical
     Documentation relating to any Improvements made or obtained by the
     Licensor that are the subject of a Supplemental Contract, after the
     expiration of the W-Contract, the Licensee shall continue to have the
     fight to use all Technical Information and Technical Documentation (but
     not including any valid patents) within the scope of the transfer as of
     the date of expiry and Licensor shall not use any reason to interfere with
     this fight. However, the Licensee shall not have the fight to transfer or
     sublicense the Licensed Technology to any third party without Licensor's
     consent.

                               ARTICLE 10 - TAXES

10.1 All taxes arising in connection with the performance of this Contract that
     are imposed on the Licensee in accordance with the tax laws of the
     People's Republic of China shall be borne by the Licensee.

10.2 All taxes imposed on Licensor in accordance with the tax laws of the
     People's Republic of China shall be borne by Licensor. In the event that
     any tax is imposed by withholding, the Licensee shall provide Licensor
     forthwith with the original tax receipt issued by the relevant tax bureau.




                                       27

<PAGE>


10.3 All taxes imposed outside the People's Republic of China in connection
     with payments made to Licensor under this Contract shall be borne by
     Licensor.

                        ARTICLE 11 - DISPUTE SETTLEMENT

11.1 Any disputes arising from the execution of or in connection with this
     Contract shall be settled through friendly consultations between the
     Parties. In case no settlement can be reached through consultations within
     sixty (60) days after a Party has given notice to the other Party of the
     matter in dispute, the disputes shall be submitted to the China
     International Economic and Trade Arbitration Commission in accordance with
     it's existing rules of arbitration. The arbitration award is final and
     binding upon both Parties.

11.2 During the arbitration, this Contract shall be performed continually by
     the Parties except for matters in dispute, and the arbitration proceedings
     shall not prevent any Party from exercising its right of termination under
     this Contract.

                           ARTICLE 12 - FORCE MAJEURE

12.1 Should the performance of this Contract be affected directly or indirectly
     or this Contract could not be executed in accordance with the provisions
     prescribed herein due to force majeure, such as earthquake, typhoon,
     flood, fires, war and other unforeseen events, and their happening and
     consequences are unpreventable or unavoidable, the Party which has been
     prevented from performing its obligations shall notify the other Party by
     facsimile without any delay, and within 15 days thereafter providing
     detailed information of the events and a valid document of evidence issued
     by the local public notary organisation stating the reasons for failing to
     carry out or partly carry out or postponing performance of its obligations
     under this Contract.

     Thereafter, the Party whose contractual obligations are affected by the
     aforesaid event of force majeure shall be suspended for the period of the
     force majeure and the period for performing such obligations shall be
     extended, without penalty, for a period equal to such suspension.





                                       28

<PAGE>


12.2 Should such event of force majeure hinder the performance of this Contract
     or the operation of the Licensee for a period of more than six (6) months,
     the Parties shall decide by mutual agreement whether to terminate this
     Contract prematurely.

     In case of early termination, neither Party shall be held liable for the
     consequences of early termination caused by such event of force majeure.

12.3 Notwithstanding the foregoing, the Parties shall use all reasonable
     endeavours to minimise the impact of such event of force majeure and find
     an equitable solution for the same, and the Party hindered by such event
     of force majeure shall resume performance~ of its obligations under this
     Contract as soon as possible after the cessation of the event of force
     majeure.

                           ARTICLE 13 - GOVERNING LAW

13.1 The validity, interpretation and implementation of this Contract shall be
     governed by the laws of the Peoples Republic of China.

                           ARTICLE 14 - MISCELLANEOUS

14.1 Neither Party may assign any of its rights and obligations under this
     Contract without the prior written consent of the other Party. except that
     Licensor may delegate it's rights to any of its Affiliates, provided that
     Licensor shall take full responsibility for any damage to the Licensee
     arising out of the mistakes of its delegated party.

14.2 This Contract is severable in that if any provision hereof is determined
     to be illegal or unenforceable, the offending provision shall be stricken
     without affecting the remaining provisions of this Contract.

14.3 This Contract is executed in English and Chinese. While both are valid
     versions of the Contract, in the event of a conflict the English versions
     shall prevail.

14.4 This Contract, together with any documents referred to herein, constitutes
     the entire agreement between the Parties with respect to the subject
     matter hereof, supersedes any prior expression of intent or understanding
     relating hereto and may only be modified or amended by a written
     instrument signed by the authorised representatives of the Parties. Major
     amendments shall enter into effect when approved by the Approval
     Authority.





                                       29

<PAGE>


14.5 Failure or delay on the part of either Party hereto to exercise any right,
     power or privilege under this Contract shall not operate as a waiver
     thereof; nor shall any single or partial non-exercise of any right, power
     or privilege preclude any other future exercise thereof

14.6 Should any notices in connection with any Party's Tights and obligations
     be sent by either telegram of telex, then all such notices shall be
     followed by written letter. The legal addresses of both Parties to this
     Contract shall be the posting addresses.

This Contract is signed by their duly authorised representatives of both
Parties as of the date first above written,


By:                                          By:
   ----------------------------------           --------------------------------
Name: [   ]                                  Name: Mr. James C. Foster
Title: General Manager                       Title: President
Zhanjiang A & C Biological Ltd.              Charles Rivers Laboratories Inc.





                                       30

                                                                    EXHIBIT 10.9

                                  GROUND LEASE



                                HIC ASSOCIATES,

                           A California Joint venture


                                     LESSOR




                        CHARLES RIVER LABORATORIES INC.



                                     LESSEE






                              Dated: June 5 1992.

<PAGE>

                                  GROUND LEASE

                               TABLE OF CONTENTS
                                                                          Page
                                                                          ----

I.    PARTIES; OPENING CLAUSE; WORDS OF LEASING. . . . . . . . . . . . . .   1
II.   PREMISES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   1
      A. Definition  . . . . . . . . . . . . . . . . . . . . . . . . . . .   1
      B. General Description . . . . . . . . . . . . . . . . . . . . . . .   1
      C. Legal Description . . . . . . . . . . . . . . . . . . . . . . . .   1
         1. No Existing Improvements . . . . . . . . . . . . . . . . . . .   1
III.  OPTION TO LEASE. . . . . . . . . . . . . . . . . . . . . . . . . . .   2
IV.   OPTION TO PURCHASE . . . . . . . . . . . . . . . . . . . . . . . . .   3
      A. Option to Purchase Premises . . . . . . . . . . . . . . . . . . .   3
         1. Grant of Option to Lessee. . . . . . . . . . . . . . . . . . .   3
         2. Option Period. . . . . . . . . . . . . . . . . . . . . . . . .   3
         3. Method of Exercising Option. . . . . . . . . . . . . . . . . .   3
         4. Purchase Price . . . . . . . . . . . . . . . . . . . . . . . .   4
            a. Price Set by Appraisal. . . . . . . . . . . . . . . . . . .   4
         5. Method of Payment. . . . . . . . . . . . . . . . . . . . . . .   6
V.    TERM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   7
      A. Initial Term. . . . . . . . . . . . . . . . . . . . . . . . . . .   7
VI.   RENT; SECURITY; OTHER PAYMENTS . . . . . . . . . . . . . . . . . . .   7
      A. Lessee's Covenant To Pay. . . . . . . . . . . . . . . . . . . . .   7
      B. Rent/Option Payment . . . . . . . . . . . . . . . . . . . . . . .   7
         1. Rent . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   7

                                       i

<PAGE>

         2. Option to Lease. . . . . . . . . . . . . . . . . . . . . . . .   7
         3. Cost of Living Adjustment. . . . . . . . . . . . . . . . . . .   7
         4. No Adjustment Below
            Initial Minimum Rent . . . . . . . . . . . . . . . . . . . . .   9
         5. Limitation on Upward Adjustments . . . . . . . . . . . . . . .   9
      C. Taxes; Assessments. . . . . . . . . . . . . . . . . . . . . . . .   9
         1. On Real and Personal Property. . . . . . . . . . . . . . . . .   9
         2. Prorations . . . . . . . . . . . . . . . . . . . . . . . . . .  10
            a. For First and Final Years of Term . . . . . . . . . . . . .  10
            b. For Other Property of Lessor. . . . . . . . . . . . . . . .  10
         3. Lessee's Right to Contest. . . . . . . . . . . . . . . . . . .  10
         4. Exemptions . . . . . . . . . . . . . . . . . . . . . . . . . .  11
         5. Proof of Compliance. . . . . . . . . . . . . . . . . . . . . .  12
      D. Common Area and Other Expenses. . . . . . . . . . . . . . . . . .  12
VII.  USES; PURPOSES . . . . . . . . . . . . . . . . . . . . . . . . . . .  12
VIII. IMPROVEMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . .  13
      A. Construction  . . . . . . . . . . . . . . . . . . . . . . . . . .  13
         1. Lessee's Duty to Pay Fee For Offsite improvements  . . . . . .  13
         2. Conditions of Major Construction . . . . . . . . . . . . . . .  14
            a. Introductory Clause . . . . . . . . . . . . . . . . . . . .  14
            b. Offsite Improvements. . . . . . . . . . . . . . . . . . . .  14
            c. Agreement as to Plans
               and Specifications. . . . . . . . . . . . . . . . . . . . .  14
            d. Notice of Intent to Construct . . . . . . . . . . . . . . .  15
            e. Required Governmental Permits . . . . . . . . . . . . . . .  15


                                       ii

<PAGE>


            f. Builder's Risk and Other Insurance. . . . . . . . . . . . .  15
         3. Soil Conditions. . . . . . . . . . . . . . . . . . . . . . . .  15
         4. Completion . . . . . . . . . . . . . . . . . . . . . . . . . .  16
            a. Notice of Completion. . . . . . . . . . . . . . . . . . . .  16
            b. Notice of Changes in Plans. . . . . . . . . . . . . . . . .  16
         5. Further Development. . . . . . . . . . . . . . . . . . . . . .  17
      B. Maintenance; Repairs; Alterations;
         Reconstruction. . . . . . . . . . . . . . . . . . . . . . . . . .  17
         1. Lessee Required to Maintain Premises . . . . . . . . . . . . .  17
            a. Definition of Duty; Compliance
               With Laws . . . . . . . . . . . . . . . . . . . . . . . . .  17
         2. Major and Minor Reconstructions,
            Alterations. . . . . . . . . . . . . . . . . . . . . . . . . .  18
            a. Major and Minor Distinguished . . . . . . . . . . . . . . .  18
            b. When Lessor's Approval of Plans
                 Not Required. . . . . . . . . . . . . . . . . . . . . . .  18
      C. Ownership of Improvements . . . . . . . . . . . . . . . . . . . .  18
         1. Ownership of New Improvements
            During Term. . . . . . . . . . . . . . . . . . . . . . . . . .  18
         2. Ownership at Termination . . . . . . . . . . . . . . . . . . .  19
            a. Reversion to Lessor . . . . . . . . . . . . . . . . . . . .  19
IX.   ASSIGNMENT; SUBLETTING . . . . . . . . . . . . . . . . . . . . . . .  19
      A. Assignment. . . . . . . . . . . . . . . . . . . . . . . . . . . .  19
         1. Lessee's Right to Assign . . . . . . . . . . . . . . . . . . .  19
         2. Conditions Precedent to Assignment . . . . . . . . . . . . . .  20
      B. Right to Sublet . . . . . . . . . . . . . . . . . . . . . . . . .  20


                                      iii

<PAGE>


X.    INSURANCE. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .  21
      A. Fire and Extended Coverage. . . . . . . . . . . . . . . . . . . .  21
         1. Lessee's Duty To Keep Improvements
              Insured. . . . . . . . . . . . . . . . . . . . . . . . . . .  21
         2. Builder's Risk Coverage. . . . . . . . . . . . . . . . . . . .  21
      B. Other Insurance and Indemnification . . . . . . . . . . . . . . .  22
         1. Public Liability Insurance . . . . . . . . . . . . . . . . . .  22
      C. Policy Form, Content, Insurer . . . . . . . . . . . . . . . . . .  22
      D. Failure To Maintain Insurance;
         Proof of Compliance . . . . . . . . . . . . . . . . . . . . . . .  23
      E. Lessor's Nonliability . . . . . . . . . . . . . . . . . . . . . .  24
      F. Lessee's Nonliability . . . . . . . . . . . . . . . . . . . . . .  24
XI.   CONDEMNATION . . . . . . . . . . . . . . . . . . . . . . . . . . . .  25
      A. Preliminary Provisions. . . . . . . . . . . . . . . . . . . . . .  25
         1. Definitions. . . . . . . . . . . . . . . . . . . . . . . . . .  25
         2. Notice to Other Party. . . . . . . . . . . . . . . . . . . . .  27
         3. Representative of Each Party;
            Effectuation . . . . . . . . . . . . . . . . . . . . . . . . .  27
      B. Division. . . . . . . . . . . . . . . . . . . . . . . . . . . . .  28
         1. "Just and Equitable" Division. . . . . . . . . . . . . . . . .  28
XII.  HAZARDOUS MATERIALS. . . . . . . . . . . . . . . . . . . . . . . . .  28
XIII. DEFAULT; REMEDIES. . . . . . . . . . . . . . . . . . . . . . . . . .  33
      A. Lessee's Default. . . . . . . . . . . . . . . . . . . . . . . . .  33
         1. Introductory Clause. . . . . . . . . . . . . . . . . . . . . .  33
            a. Failure To Materially Perform
               Lease Covenants . . . . . . . . . . . . . . . . . . . . . .  33


                                       iv

<PAGE>


            b. Attachment or other Levy. . . . . . . . . . . . . . . . . .  33
            c. Appointment of Receiver . . . . . . . . . . . . . . . . . .  33
            d. Insolvency, Bankruptcy  . . . . . . . . . . . . . . . . . .  34
            e. Default in Mortgage Payment . . . . . . . . . . . . . . . .  34
            f. Lessee's Right to Cure Defaults . . . . . . . . . . . . . .  34
            g. Lessor's Right To Cure Lessee's . . . . . . . . . . . . . .  35
               Defaults. . . . . . . . . . . . . . . . . . . . . . . . . .  35
      B. Lessor's Remedies . . . . . . . . . . . . . . . . . . . . . . . .  35
         1. introductory Clause. . . . . . . . . . . . . . . . . . . . . .  35
         2. Nonmonetary Remedies . . . . . . . . . . . . . . . . . . . . .  36
            a. Termination . . . . . . . . . . . . . . . . . . . . . . . .  36
            b. Reentry Without Termination . . . . . . . . . . . . . . . .  36
            c. Lessee's Personal Property. . . . . . . . . . . . . . . . .  37
         3. Monetary Remedies. . . . . . . . . . . . . . . . . . . . . . .  37
            a. Recovery of Rent. . . . . . . . . . . . . . . . . . . . . .  37
            b. Damages . . . . . . . . . . . . . . . . . . . . . . . . . .  38
            c. Assignment of Subrents. . . . . . . . . . . . . . . . . . .  38
      C. Notice of Lessor's Default; Lessee's Waiver . . . . . . . . . . .  40
      D. Provisions Applicable to Both Parties . . . . . . . . . . . . . .  40
         1. Unavoidable Default or Delay . . . . . . . . . . . . . . . . .  40
         2. Waiver, Voluntary Acts . . . . . . . . . . . . . . . . . . . .  41
         3. Attorney's Fees. . . . . . . . . . . . . . . . . . . . . . . .  41
XIV.  WATER TO PREMISES . . . . . . . . . . . . . . . .  . . . . . . . . .  42
XV.   TITLE . . . . . . . . . . . . . . . . .  . . . . . . . . . . . . . .  42
      A. Title . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .  42


                                       v

<PAGE>


      B. Restrictions . . . . . . . . . . . . . . . . . . . . . . . . . . . 42
      C. No Encumbrances . . . . . . . . . . . . . . . . . . . . .  . . . . 43
      D. Proof of Title . . . . . . . . . . . . . . . . . . . . . . . . . . 44
      E. Quiet Enjoyment. . . . . . . . . . . . . . . . . . . . . . . . . . 44
XVI.  EXCHANGE. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44
XVII. SUBORDINATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
      A. Lease To Be Prior But Subject Subordination. . . . . . . . . . . . 45
XVIII. GENERAL CONDITIONS; MISCELLANEOUS PROVISIONS . . . . . . . . . . . . 46
      A. Transactions Between Parties . . . . . . . . . . . . . . . . . . . 46
         1. Notice. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46
         2. Performance of Lessee's Covenants by Others . . . . . . . . . . 48
         3. Nonmerger of Fee and Leasehold Estates. . . . . . . . . . . . . 48
         4. Estoppel Certificates; Liquidated Damages . . . . . . . . . . . 48
         5. Joint and Several Obligations . . . . . . . . . . . . . . . . . 49
      B. Interpretation of Lease. . . . . . . . . . . . . . . . . . . . . . 49
         1. captions, Table of Contents . . . . . . . . . . . . . . . . . . 49
         2. Gender. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
         3. Singular and Plural . . . . . . . . . . . . . . . . . . . . . . 49
         4. Exhibits, Addenda . . . . . . . . . . . . . . . . . . . . . . . 49
         5. Entire Agreement. . . . . . . . . . . . . . . . . . . . . . . . 50
         6. Severability. . . . . . . . . . . . . . . . . . . . . . . . . . 50
      C. Successors . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50


                                      vi


<PAGE>


XIX. EXPIRATION; TERMINATION. . . . . . . . . . . . . . . . . . . . . . . . 50
      A. Lessee's Duty to Surrender . . . . . . . . . . . . . . . . . . . . 50
      B. Holding Over . . . . . . . . . . . . . . . . . . . . . . . . . . . 51
      C. Termination. . . . . . . . . . . . . . . . . . . . . . . . . . . . 51
XX.  EXECUTION; MEMORANDUM OF LEASE . . . . . . . . . . . . . . . . . . . . 51
      A. Execution in Counterparts. . . . . . . . . . . . . . . . . . . . . 51
      B. Recordation of Memorandum of Lease Only. . . . . . . . . . . . . . 52

                                    -000-




                                     vii
BOSSO, WILLIAMS
LEVIN, SACHS & BOOK
A PROFESSIONAL
CORPORATION
133 MISSION STREET
SUITE 250
POST OFFICE BOX 1832
SANTA CRUZ
CALIFORNIA 25061-L1822
TELEPHONE
(408) 426-8484
FAX (408) 423-2830
(408) 423-2830
<PAGE>


                                 GROUND LEASE

         I. PARTIES; OPENING CLAUSE; WORDS OF LEASING

         This Ground Lease is made on January 1, 1992, between HIC ASSOCIATES,
a Joint Venture, hereinafter called "Lessor," and CHARLES RIVER LABORATORIES,
INC., hereinafter called "Lessee."

         Lessor leases to Lessee, and Lessee hires from Lessor, the Premises
hereafter described.


                                 1II. PREMISES

A. Definition. Except as expressly provided to the contrary in this Lease,
reference to "Premises" is to the described land plus any described
appurtenances, exclusive of any improvements now or hereafter located on the
Premises, notwithstanding that any such improvements may or shall be construed
as affixed to and as constituting part of the real property, and without
regard to whether ownership of the improvements is in the name of Lessor or in
the Lessee.

B. General Description.

         1. The Premises is commonly referred to as 1000 Park Center Drive
(Parcel 10), Hollister, California 95023. The land is unimproved.

C. Legal Description.

         1. No Existing Improvements. The legal description of the Premises is
included in Exhibit A, attached to this Lease and initialed by the parties.


                                       1

<PAGE>

                             III. OPTION TO LEASE

A. Lessee shall have an exclusive option to lease Parcel 9, commonly referred to
as 900 Park Center Drive, Hollister, California 95023. Said land is unimproved.

B. Said exclusive option to lease may be exercised at any time during the five
(5)-year period following the date of execution of this Lease (the "Option
Period"). If said option is exercised, the Lease shall be on the same terms and
conditions (including, without limitation, rent and payment terms) as for
Parcel 10.

C. For Parcel 9 to be included within the option to purchase, as described
below, Lessee must exercise this option to lease within the option Period.

D. Upon Lessee's exercise of the option to lease granted pursuant to this
Article III and, if applicable, the option to purchase granted pursuant to
Article IV below, Parcel 9 shall automatically be deemed part of the "Premises"
for purposes hereof; provided, however, that Lessee shall have the option, at
Lessee's discretion, to purchase only one of the parcels comprising the Premises
in accordance with Article IV, Paragraph A. 1. hereof. A legal description of
Parcel 9 is included in Exhibit A, attached to this Lease and initialed by the
parties.

E. Lessor hereby agrees not to sell the Premises or, if not yet leased by
lessee, Parcel 9, or to lease Parcel 9 in violation of this Article III, or to
pledge, grant a security interest in, or otherwise encumber the Premises or, if
not yet leased by Lessee,


                                      2
<PAGE>



Parcel 9, or commit to do any of the foregoings, in a manner which could
prohibit Lessee from receiving clear title to the Premises and, if not yet
leased, Parcel 9, on a timely basis as contemplated in Article IV hereof, so
long as Lessee continues to make payments pursuant to Article VI, Paragraph B.
2. below.


                            IV. OPTION TO PURCHASE

A. Option To Purchase Premises.

         1. Grant of Option to Lessee. Lessor hereby grants to Lessee an
exclusive option to purchase, at Lessee's discretion, one or, if applicable
and Lessee so chooses, both of the parcels comprising the Premises in
accordance with the provisions of this Lease, as long as Lessee is not in
default with respect to any of its payment obligations hereunder at the time
Lessee exercises the option. If Lessee is also leasing Parcel 9 at the time of
exercise of this option to purchase, said option shall automatically extend to
Parcel 9. If Lessee is not so leasing Parcel 9, this option shall extend only
to the Premises, as initially defined.

         2. Option Period. Lessee shall have the right to exercise the option
to purchase at any time during the period commencing on January 1, 1997, and
ending on the expiration or termination of this Lease (the "Purchase Period").

         3. Method of Exercising Option. Lessee shall exercise the option by
giving written notice ("Option Notice") to Lessor at any time within the
Purchase Period.


                                      3
<PAGE>


4. Purchase Price.

         a. Price set by Appraisal. The parties shall have thirty (30) days
after Lessor receives the Option Notice in which to agree on the purchase
price for the Premises (the "Purchase Price"). If the parties are unable to
agree on the Purchase Price within such thirty (30)-day period, then within
ten (10) days after the expiration of such period, (i) Lessee shall provide
Lessor with a written statement setting forth what Lessee believes to be the
maximum reasonable purchase price for the Premises (the "Lessee Price") and
(ii) each party, at its respective cost and by giving notice to the other
party, shall appoint a qualified real estate appraiser with at least five (5)
years' full-time commercial appraisal experience in Northern California to
establish the Purchase Price. If a party does not appoint an appraiser within
ten (10) days after it has received written notice from the other party of the
name of its appraiser, the single appraiser appointed shall be the sole
appraiser and shall set the Purchase Price of the Premises. If two appraisers
are appointed by the parties in accordance with this paragraph, they shall
meet promptly (but in no event more than five (5) days after the appointment
of the latter appraiser), and attempt to establish the Purchase Price. If
they are unable to agree on the Purchase Price within thirty (30) days after
the second appraiser has been appointed, they shall attempt to select a third
appraiser meeting the qualifications stated in this paragraph within ten (10)
days after the last day



                                      4
<PAGE>



the two appraisers are given to establish the Purchase Price. If they are
unable to agree on the third appraiser, either of the parties to this Lease by
giving ten (10) days' notice to the other party can apply to the then
Presiding Judge of the Superior Court in the county in which the Premises are
located, for the selection of a third appraiser who meets the qualifications
stated in this paragraph. Each of the parties shall bear one-half (1/2) of the
cost of appointing the third appraiser and of paying the third appraiser's
fee. The third appraiser, however selected, shall be a person who has not
previously acted in any capacity for either party.

         Within thirty (30) days after the selection of the third appraiser, a
majority of the appraisers shall establish the Purchase Price. If a majority
of the appraisers is unable to set the Purchase Price within the stipulated
period of time, the three appraisals shall be added together and their total
divided by three; the resulting quotient shall be the Purchase Price. In
appraising the Premises as provided in this paragraph, the appraisers shall
not take into consideration the existence of this Lease or the Lessee Price.

         After the Purchase Price for the Premises has been established, the
appraisers shall immediately notify the parties. In no event, however, shall
the Purchase Price be less than Three Dollars ($3.00) per square foot.


                                      5
<PAGE>


         Once established in accordance with the terms of this paragraph, the
Purchase Price shall be binding on Lessor and Lessee. Lessee may thereafter
proceed with the purchase of the Premises in accordance with this Article IV;
provided, however, that Lessee shall not be obligated to effect such a
purchase if the Purchase Price established in accordance with this Article IV
is greater than the Lessee Price, in which case this Lease shall continue in
full force and effect and the Lessee shall continue to have the right to
exercise the option granted under this Article IV at any time thereafter
during the term of this Lease or any extensions thereof.

         In the event Lessee elects to proceed with the purchase of the Premises
in accordance with this Article IV, Lessor and Lessee hereby covenant and
agree to use their respective best efforts and to take all actions necessary
to effect the closing of such purchase and the transfer of title to Lessee
within thirty (30) days of Lessee's election to proceed with such purchase.

         5. Method of Payment. The Purchase Price shall be payable in cash in
lawful money of the United States to Lessor by Lessee at close of escrow (the
date the grant deed is recorded). Escrow shall close within thirty (30) days
of establishing the Purchase Price. The costs of escrow shall be shared
equally in accordance with the custom of the county in which the Premises are
located.


                                      6

<PAGE>


                                   V. TERM

A. Initial Term. The term of this Lease is thirty-four (34) full calendar
years, beginning January 1, 1992, and ending at midnight on January 1, 2026,
unless extended or sooner terminated as provided for in this Lease. Lessee
shall have the option to terminate this Lease at any time after January 1,
1997, upon delivery of six (6) months written notice to Lessor.


                      VI. RENT; SECURITY; OTHER PAYMENTS

A. Lessee's Covenant To Pay. Lessee shall pay the following sums; provided
that Lessee shall have the right to offset any such payments to be made
pursuant to this Article VI against any fees, expenses or charges paid or
incurred by Lessee due to Lessor's failure to perform under this Lease

B. Rent/Option Payment.

         1. Rent. Thirty-Six Thousand Dollars ($36,000.00) to Lessor per annum,
as rent payable in advance on the anniversary date of the date of this Lease,
so long as this Lease remains in effect.

         2. Option to Lease. Twenty-Four Thousand Dollars ($24,000.00) to Lessor
per annum payable in advance on the date of execution of this Lease and the
first through fourth anniversary dates of the date of this Lease, so long as
this Lease remains in effect during such period, as consideration for the
option to lease Parcel 9, all as set forth above.

         3. Cost of Living Adjustment. The minimum annual net rent required to
be paid pursuant to Paragraph B. 1. of this Article VI



                                      7
<PAGE>


shall be adjusted upward or downward as of the first (1st) day of each year
(the adjustment date) beginning on the first day of the second year of the
lease term, according to the following computation:

         The base for computing the adjustment is the index figure for the month
nearest the commencement date of the lease term (the index date), as shown in
the Consumer Price Index (CPI) for All items--U.S. Average/Housing--San
Francisco-Oakland based on the period 1957-1959 = 100 as published by the U.S.
Department of Labor's Bureau of Labor Statistics.

         The index for the adjustment date shall be computed as a percentage of
the base figure. For example, assuming the base figure on the index date is
110 and the index figure on the adjustment date is 121, the percentage to be
applied is 121/110 = 1.10 = 110 Percent. That percentage shall be applied to
the initial minimum annual net rent for the period beginning on the adjustment
date and continuing until the next adjustment date.

         The index for the adjustment date shall be the one reported in the U.S.
Department of Labor's most comprehensive official index then in use and most
nearly answering the foregoing description of the index to be used. If it is
calculated from a base different from the base period 1957 - 1959 = 100 used
for the base figure above, the base figure used for calculating the adjustment
percentage shall first be converted under a formula supplied by the Bureau.


                                      8
<PAGE>


         If the described index shall no longer be published, another generally
recognized authoritative source shall be substituted by agreement of the
parties. If they are unable to agree within thirty (30) days after demand by
either party, the substitute index shall, on application of either party, be
selected by the chief officer of the San Francisco regional office of the
Bureau of Labor Statistics or its successor.

         4. No Adjustment Below Initial Minimum Rent. In no event shall the
amount of minimum annual net rent be reduced below the initial amount
specified in Article VI, Paragraph B. 1.

         5. Limitation on Upward Adjustments. In no event shall the amount of
minimum annual rent be increased by more than ten percent (10%) by reason of any
adjustment pursuant to Article VI, Paragraph B. 3.

C. Taxes; Assessments.

         1. On Real and Personal Property.  All real and personal property
taxes, general and special assessments, annexation fees, and other charges of
every description levied on or assessed against the Premises, improvements
located on the Premises, personal property located on or in the Premises or
the improvements thereon, the leasehold estate, or any subleasehold estate, to
the full extent of installments falling due during the term, whether belonging
to or chargeable against Lessor or Lessee. Lessee shall make all such payments
directly to the charging authority before delinquency and before any fine,
interest, or penalty shall become


                                      9
<PAGE>



due or be imposed by operation of law for their nonpayment. If, however, the
law expressly permits the payment of any or all of the above items in
installments (whether or not interest accrues on the unpaid balance), Lessee
may, at Lessee's election, utilize the permitted installment method, but shall
pay each installment with any interest before delinquency.

         2. Prorations.

            a. For First and Final Years of Term. All payments of taxes or
assessments, or both, shall be prorated for the initial lease year and for the
year in which the lease terminates.

            b. For Other Property of Lessor. If the Premises are assessed with
other property of Lessor for purposes of Property taxes, assessments, or other
ad valorem or improvement levies (collectively referred to in this paragraph
as taxes), all taxes imposed on the entire parcel of which the Premises are a
part shall, until the Premises are separately assessed, be prorated such that
Lessee shall pay (i) 19.5% of the entire tax computed in the event the
Premises are comprised solely of Parcel 10 or (ii) 39% of the entire tax
computed if the Premises are comprised of Parcels 9 and 10.

         3. Lessee's Right to Contest. Lessee may contest the legal validity or
amount of any taxes, assessments, or charges for which Lessee is responsible
under this Lease, and may institute such proceedings as Lessee considers
necessary at Lessee's sole expense. If Lessee contests any such tax,
assessment, or charge, Lessee may



                                      10
<PAGE>


withhold or defer payment or pay under protest but shall indemnify Lessor and
the Premises from any lien.

         Lessor appoints Lessee as Lessor's attorney-in-fact for the purpose
of making all payments to any taxing authorities and for the purpose of
contesting any taxes, assessments, or charges, conditioned on Lessee's
preventing any liens from being levied on the Premises or on Lessor (other
than the statutory lien of Revenue and Taxation Code Section 2187).

         4. Exemptions. Lessee's obligation to pay taxes or assessments levied
or charged against the Premises or improvements or against specified personal
property shall not include the following, whatever they may be called:
business income, or profits taxes levied or assessed against Lessor by
federal, state, or other governmental agency; estate, succession, inheritance,
or transfer taxes of Lessor; or corporation, franchise, or profits taxes
imposed on the corporate owner of the fee title of the Premises. If, however,
during the term, taxes are imposed, assessed, or levied on the rents derived
from the Premises in lieu of all or any part of real property taxes, personal
property taxes, or real and personal property taxes that Lessee would have
been obligated to pay under the foregoing provisions, and the purpose of the
new taxes is more closely akin to that of an ad valorem or use tax than to an
income or franchise tax on Lessor's income, Lessee shall pay the taxes as
provided above for property taxes and assessments.



                                      11
<PAGE>


         5. Proof of Compliance. Lessee shall furnish to Lessor, upon request,
receipts or other appropriate evidence establishing Lessee's tax payment.
Lessee may at its discretion comply with this requirement by retaining a tax
service to notify Lessor whether the taxes have been paid.

D. Common Area and Other Expenses. Lessee shall pay its proportionate share
(19.5% if the Promises are comprised solely of Parcel 10 or 39% if the
Premises are comprised of Parcels 9 and 10) of all common area expenses listed
on Exhibit B, attached hereto and initialed by the parties, including
liability insurance and water facilities (which will be separately metered)
within thirty (30) days of receiving Lessor's annual invoice with reasonable
documentation attached. Extraordinary expense items, which have been
previously approved by Lessee in writing, except for emergency repairs, and
water billings will be billed upon occurrence. Upon connection to City of
Hollister, California (the "City") sewer and water services, Lessee shall pay
directly to City for services metered and used by Lessee. Lessor hereby
represents that it is its best good-faith estimate that Lessee's proportionate
share of such common area expenses, not including taxes and special
assessments, will not exceed One Thousand Dollars ($1,000.00) per year.


                             VII. USES; PURPOSES

         Lessee shall use and permit the use of the Premises primarily for the
construction, maintenance, and operation of a rodent


                                      12
<PAGE>


breeding facility and general office and administration, provided that Lessee
may at any time use the existing or subsequent improvements, or permit them to
be used, for any lawful purpose. Provided further that Lessee shall at all
times comply with any and ail government regulations and/or restrictions
governing Lessee's use. Lessor represents and warrants that the Premises
(which term shall include Parcels 9 and 10 for purposes of this Article VII)
are presently zoned for operation of a rodent breeding facility and the
general office and administration activities associated therewith, and Lessor
knows, without any independent investigation an its part, of no current or
pending regulations, ordinances or other laws which would prohibit or limit
Lessee's proposed use of the Premises as an operating rodent breeding
facility.


                              VIII. IMPROVEMENTS

A. Construction.

         1. Lessee's Duty to Pay Fee For Offsite Improvements. Within thirty
(30) days of the date of execution of this Lease, Lessee will deliver to
Lessor a check in the amount of Two Hundred Twenty Thousand Dollars
($220,000.00), representing a one-time fee covering offsite development
expenses in connection with its lease of Parcel 10. In consideration of
receipt of such fee, Lessor will construct the off-site improvements specified
in Exhibit C, attached hereto, in accordance with the specifications and
construction schedule set forth in such Exhibit C. If Lessee elects to lease
or purchase Parcel 9, it will be required to pay


                                      13
<PAGE>


HIC Associates for services rendered an additional one-time fee of Two
Hundred Twenty Thousand Dollars ($220,000.00) on the date of its Lease or
purchase of Parcel 9. Lessor shall consult with Lessee's engineering personnel
in connection with the construction of the offsite improvements on Parcel 10
and, if applicable, Parcel 9, and will cooperate with Lessee in ensuring that
such offsite improvements meet Lessee's presently projected needs.

         2. Conditions of Major Construction.

            a. Introductory Clause. Before any major work of construction is
commenced on the Premises, and before any building materials have been
delivered to the Premises by Lessee or under Lessee's authority, Lessee shall
comply with all the following conditions or procure Lessor's written waiver of
the condition or conditions specified in the waiver:

            b. Offsite Improvements. Lessee shall have paid Lessor the
$220,000.00 fee for construction of all offsite improvements in accordance
with the specifications and construction schedule set forth in Exhibit C
hereto.

            c. Agreement as to Plans and Specifications. The plans,
specifications and designs shall be substantially the same as is attached
hereto marked Exhibit D, and by this reference incorporated herein, the same
to be submitted to San Benito County for issuance of appropriate permits.
Lessor acknowledges and agrees that the plans, specifications and designs so
attached as Exhibit D relate to Parcel 10, and the aforementioned approval by



                                      14
<PAGE>



San Benito County applies to plans, specifications and designs submitted with
respect to Parcel 10.

            d. Notice of intent to Construct. Notify Lessor of Lessee's
intention to commence a work of improvement at least three (3) days before
commencement of any such work or delivery of any materials. Lessor shall have
the right to post and maintain an the Premises any notices of
nonresponsibility provided for under applicable law, and to inspect the
Premises in relation to the construction at all reasonable times, upon prior
written notice to Lessee.

            e. Required Govermental Permits. Procure and deliver to Lessor at
Lessee's expense evidence of compliance with all then applicable codes,
ordinances, regulations, and requirements for permits and approvals, including
but not restricted to a grading permit, building permits, zoning and planning
requirements, and approvals from various governmental agencies and bodies
having jurisdiction.

            f. Builder's Risk and Other Insurance. Deliver to Lessor (1)
certificates of insurance evidencing coverage for "builder's risk," and (2)
evidence of worker's compensation insurance in the State of California.

         3. Soil Conditions. Except as provided to the contrary in Article XII
of this Lease, Lessor makes no covenants or warranties respecting the
condition of the soil or subsoil or any other condition of the Premises.
Lessee may enter onto the land before


                                      15
<PAGE>



commencement of the term to make environmental, soil and structural
engineering tests that Lessee considers necessary. All such tests made by or
on behalf of Lessee shall be at Lessee's sole expense and shall be evidenced
by a separate contract. A copy of the report shall be delivered to Lessor on
commencement of the term. The receipt of test results satisfactory to Lessee
is of the essence of this Lease and is expressly made a condition precedent to
this Lease. In the event such tests yield evidence of contamination of the
soil or subsoil of the Premises, giving rise to liability, this Lease shall be
declared a nullity and Lessor shall promptly refund to Lessee all amounts
previously paid hereunder. Thereafter, neither party shall have any
liabilities or obligations to the other arising out of this Lease.

4. Completion.

            a. Notice of Completion. On completion of any substantial work of
improvement during the term, Lessee shall file or cause to be filed a notice
of completion.

            b. Notice of Changes in Plans. On completion of any work of
improvement, Lessee shall give Lessor notice of all changes in plans or
specifications made during the course of the work and shall, at the same time
and in the same manner, supply Lessor with "as built" drawings accurately
reflecting all such changes. Lessor acknowledges that it is common practice in
the construction industry to make numerous changes during the course of
construction on substantial projects. Changes that do not substantially alter


                                      16
<PAGE>


plans and specifications previously approved by Lessor do not constitute a
breach of Lessee's obligations.

         5. Further Development. Lessor represents and warrants that any
development of the undeveloped lots within the subdivision (including Parcel
9, if not purchased by Lessee) shall be of a quality and character reasonably
consistent with Lessee's operations and shall be limited to light industrial
uses.

D. Maintenance; Repairs; Alterations; Reconstruction.

         1. Lessee Required To Maintain Premises.

            a. Definition of Duty; Compliance With Laws. Throughout the term,
Lessee shall, at Lessee's sole cost and expense, maintain the Premises and all
improvements in reasonable condition and repair, ordinary wear and tear
excepted, and in accordance with all applicable laws, rules, ordinances,
orders and regulations of (1) federal, state, county, municipal, and other
governmental agencies and bodies having or claiming jurisdiction and all their
respective departments, bureaus, and officials; (2) the insurance
underwriting board or insurance inspection bureau having or claiming
jurisdiction; and (3) all insurance companies insuring all or any part of the
Premises or improvements or both. Lessor hereby represents and warrants
that, to the best of Lessor's knowledge, as of the date of this Lease, the
Premises and all improvements thereon have been maintained in accordance with
all of the foregoing laws, rules, ordinances, orders and regulations.


                                      17
<PAGE>



         Nothing in this Lease shall be construed as limiting any right given
elsewhere in this Lease to alter, modify, demolish, remove, or replace any
improvement. No deprivation, impairment, or limitation of use resulting from
any event or work contemplated by the preceding paragraph shall entitle Lessee
to any offset, abatement, or reduction in rent nor to any termination or
extension of the term.

         2. Major and Minor Reconstructions, Alterations.

            a. Major and Minor Distinguished. Lessor's approval is not required
for Lessee's minor alterations, or additions. "Minor" means a construction
cost not exceeding Five Hundred Thousand Dollars ($500,000.00). "Major"
alterations or additions are those not defined as minor above. For major
alterations or additions, Lessee shall comply with all conditions of Major
Construction elsewhere in this Lease.

            b. When Lessor's Approval of Plans Not Required. If Lessee's
proposed work does not substantially alter the then-existing use of the
Premises, Lessor's approval of plans and specifications shall not be required.
If Lessor's approval is required, the provision relating to Lessor's approval
in the conditions of Major Construction shall apply.

C. Ownership of Improvements.

         1. Ownership of New Improvements During Term. All improvements
constructed on the Premises by Lessee as permitted by this Lease shall be
owned by Lessee until expiration of the term


                                      18
<PAGE>


or sooner termination of this Lease. Lessee shall not, however,
waste or destroy any improvements on the Premises, but may repair
and modify such improvements at Lessee's discretion. The parties
covenant for themselves and all persons claiming under them that
the improvements are real property.

         2. Ownership at Termination.

            a. Reversion to Lessor. All improvements an the Premises at the
expiration of the term or sooner termination of this Lease shall, without
compensation to Lessee, then become Lessor's property free and clear of all
claims to or against them as of the date of transfer by Lessee or any third
person, and Lessee shall defend and indemnify Lessor against all liability and
loss arising from any such claims made on or before date of transfer or from
Lessor's exercise of the rights conferred by this paragraph. Lessor and Lessee
understand and agree that Lessee shall be obligated under this provision to
leave only the concrete building shell and any existing infrastructure or
landscaping improvements following the expiration or termination of this Lease
and Lessor shall have no claim that any other improvements constitute property
of the Lessor.


                         IX. ASSIGNMENT; SUBLETTING

A. Assignment.

         1. Lessee's Right to Assign. Lessee shall have the right to assign or
otherwise transfer Lessee's interest in this Lease and the estate created by
this Lease only with the consent of the


                                      19
<PAGE>




Lessor, which consent shall not be unreasonably withheld. Notwithstanding the
foregoing, Lessee shall be free to assign or otherwise transfer Lessee's
interest in this Lease and the estate created by this Lease without Lessor's
consent to any successors, assigns or affiliates of the Lessee or to any other
third party engaged in the rodent breeding business.

         2. Conditions Precedent to Assignment. The following are conditions
precedent to Lessee's right of assignment:

            a. Lessee shall give Lessor reasonable notice of the proposed
assignment.

            b. The proposed assignee shall, in recordable form, expressly assume
all the covenants and conditions of this Lease.

B. Right to Sublet. Lessee shall have the absolute right to sublet all or any
part or parts of the Premises or the improvements or both, and to assign,
encumber, extend, or renew any sublease, provided the following provisions are
complied with:

         1. Each sublease shall contain a provision, reasonably satisfactory to
Lessor requiring sublessee to attorn to Lessor.

         2. Lessee shall, promptly after execution of each sublease, notify
Lessor of the name and mailing address of the sublessee and shall, an demand,
permit Lessor to examine and copy the sublease.

         3. Lessee shall not accept, directly or indirectly, more than
one (1) month's prepaid rent from any sublessee.
Lessor agrees, from time to time at Lessee's request, to
execute and deliver a non-disturbance and attornment agreement with


                                      20
<PAGE>



Lessor and any sublessee of the entire Premises for the purpose of providing
that, in the event of the termination of this Lease, Lessor shall not disturb
the possession of such sublessee and shall recognize such sublessee's rights
under any sublease executed in accordance with this Paragraph B., and that
notwithstanding a termination of this Lease, such sublease shall continue in
full force and effect; provided such sublessee is not in default of any of the
material terms of its sublease or this Ground Lease.


                                 X. INSURANCE

A. Fire and Extended Coverage.

         1. Lessee's Duty To keep Improvements Insured. Throughout the term, at
Lessee's sole cost and expense, Lessee shall keep or cause to be kept insured
for the benefit of Lessee, all improvements located on the Premises against
loss or damage by fire and such other risks as are now or hereafter included
in an extended coverage endorsement in common use for commercial structures,
including vandalism and malicious mischief. The amount of the insurance shall
be established at Lessee's reasonable discretion.

         2. Builder's Risk Coverage. Before commencement of any demolition or
construction, Lessee shall procure, and shall maintain in force until
completion and acceptance of the work, "all risks" builder's risk insurance
including vandalism and malicious mischief, in form and with a company
reasonably acceptable to Lessor, covering improvements in place and all
material and


                                      21
<PAGE>



equipment at the job site furnished under contract, but excluding
contractor's, subcontractor's, and construction manager's tools and
equipment and property owned by contractor's or subcontractor's employees,
with limits satisfactory to Lessee.

B. Other Insurance and Indemnification.

         1. Public Liability lnsurance. Throughout the term, at Lessee's sole
cost and expense, Lessee shall keep or cause to be kept in force, for the
mutual benefit of Lessor and Lessee, commercial broad form general liability
insurance against claims and liability for personal injury, death, or property
damage arising from the use, occupancy, disuse, or condition of the Premises,
improvements, or adjoining areas or ways, providing single limit coverage of
at least Two Million Dollars ($2,000,000.00). As to any common areas, Lessor
shall similarly keep or cause to be kept in force, as a common area expense
general liability insurance, of the type and in the coverage amount specified
above, for the mutual benefit of Lessor and Lessee, against liability for
personal injury, death or property damage arising from Lessor'S negligence or
willful acts or omissions.

C. Policy Form, Content, Insurer. All insurance required by express provisions
of this Lease shall be carried only in responsible insurance companies
licensed to do business in the State of California. The Lessor shall make no
claim for recovery against Lessee for damages to or loss of the demised
Premises or improvements thereon if such damage or loss is covered by any


                                      22
<PAGE>



policy of insurance protecting the Lessor and which contains a clause
permitting the insured to waive such rights prior to the occurrence of a loss.
Lessee shall furnish Lessor upon request with certificates evidencing the
insurance. Within one hundred twenty (120) days after commencement of the
Lease, Lessee shall furnish Lessor with certificates representing all
insurance required by this Lease. Lessee may effect for its own account any
insurance not required under this Lease. Lessee may provide by blanket
insurance covering the promises and any other location or locations any
insurance required or permitted under this Lease.

D. Failure to Maintain Insurance; Proof of Compliance. Lessee shall deliver to
Lessor, upon request and in the manner rectuired for notices, copies of
certificates of all insurance policies required by this Lease, together with
evidence reasonably satisfactory to Lessor of payment required for procurement
and maintenance of the policy.

         If Lessee fails or refuses to procure or to maintain insurance as
required by this Lease and such failure shall continue for thirty (30) days
after Lessee receives Lessor's written notice thereof, then Lessor shall have
the right, at Lessor's election and without notice, to procure and maintain
such insurance. The reasonable premiums paid by Lessor shall be treated as
added rent due from Lessee, to be paid on the first day of the month
following the date on which the premiums were paid. Lessor shall give prompt



                                      23
<PAGE>

written notice of the payment of such premiums, stating the amounts
paid and the names of the insurer or insurers.

E. Lessor's Nonliability. Lessor shall not be liable, and Lessee shall defend
and indemnify Lessor against all liability and claims of liability, for
damage or injury to person or property on or about the Premises from any
cause, except Lessor's negligence, willful malfeasance, or breach of this
Lease, or the negligence or willful malfeasance of any of Lessor's agents,
employees, hirees or invitees. Except as set forth in Paragraph F below,
Lessee waives all claims against Lessor for damage or injury to person or
property arising, or asserted to have arisen, from any cause whatsoever,
except Lessor's negligence, willful malfeasance, or breach of this Lease, or
the negligence or willful malfeasance of any of Lessor's agents, employees,
hirees or invitees.

F. Lessee's Nonliability. Lessee shall not be liable, and Lessor shall defend
and indemnify Lessee against all liability and claims of liability, for damage
or injury to personal property occurring in any common area from any cause,
except Lessee's negligence, willful malfeasance, or breach of this Lease, or
the negligence or willful malfeasance of any of Lessee's agents, employees,
hirees or invitees. Except as set forth in Paragraph E. above, Lessor waives
all claims against Lessee for damage or injury to person or property arising,
or to have arisen, from any cause whatsoever, except Lessee's negligence,
willful malfeasance, or breach of this



                                      24
<PAGE>


Lease, or the negligence or willful malfeasance of any of Lessee's agents,
employees, hirees or invitees.


                              XI. CONDEMNATION

A.Preliminary Provisions.

         1. Definitions. The following definitions apply in construing
provisions of this Lease relating to a taking of or damage to all or any part
of the Premises or improvements or any interest in them by eminent domain or
inverse condemnation:

            a. Taking means the taking or damaging, including severance damage,
by eminent domain or by inverse condemnation or for any public or quasi-public
use under any statute. The transfer of title may be either a transfer
resulting from the recording of a final order in condemnation or a voluntary
transfer or conveyance to the condemning agency or entity under threat of
condemnation, in avoidance of an exercise of eminent domain, or while
condemnation proceedings are pending. The taking shall be considered to take
place as of the later of (i) the date actual physical possession is taken by
the condemnor, or (ii) the date on which the right to compensation and damages
accrues under the law applicable to the Premises.

            b. Total taking means the taking of the fee title to all the
Premises and the improvements an the Premises, which shall be considered to
include any offsite improvements effected by Lessee to serve the Premises or
the improvements on the Premises.



                                      25
<PAGE>


            c. Substantial taking means the taking of so much of the Premises
or improvements or both the conduct of Lessee's business on the Premises would
be substantially prevented or impaired.

            d. Partial taking means any taking of the fee title that is not
either a total or a substantial taking.

            e. Improvements means all products of skill, artifice, plan, or
design for construction on, modification of, or planned use of existing
structures, natural or cultivated, or earth contours on the Premises,
including but not limited to: buildings, structures, fixtures, fences, utility
installations, excavations, surfacing, water banks or channels, and grading;
landscaping, ground cover, planting, and earth contours forming part of a
landscaping design; and artistic and ornamental components of any of the
above.

            f. Notice of intended taking means any written notice or
notification on which a reasonably prudent man would rely and which he would
interpret as expressing an existing intention of taking as distinguished from
a mere preliminary inquiry or proposal. It includes, but is not limited to,
the service of a condemnation summons and complaint on a party to this Lease.
The notice is considered to have been received when a party to this Lease
receives from the condemning agency or entity a notice of intent to take, in
writing, containing a description or map of the taking reasonably defining the
extent of the taking.



                                      26
<PAGE>


            g. Award means compensation paid for the taking whether pursuant to
judgment or by agreement or otherwise.

         2. Notice to Other Party. The party receiving any notice of the kinds
specified below shall promptly give the other party written notice of the
receipt, contents, and date of the notice received:

            a. Notice of intended taking;

            b. Service of any legal process relating to condemnation of the
Premises or improvements;

            c. Notice in connection with any proceedings or negotiations with
respect to such a condemnation; or

            d. Notice of intent or willingness to make or negotiate a private
purchase, sale, or transfer in lieu of condemnation.

         3. Representative of Each Party; Effectuation. Lessor, Lessee, and all
persons and entities holding under Lessee shall each have the right to
represent his or its respective interest in each proceeding or negotiation
with respect to a taking or intended taking and to make full proof of his or
its claims. No agreement, settlement, sale, or transfer to or with the
condemning authority shall be made without the consent of Lessor and Lessee.
Lessor and Lessee each agrees to execute and deliver to the other any
instruments that may be reasonably required to effectuate or facilitate the
provisions of this Lease relating to condemnation.



                                      27
<PAGE>


B.  Division.

         1. "Just and Equitable" Division. In the event of a total, substantial,
or partial taking, the rights of the parties with respect to the term, the
rent, and the award shall be as the parties then agree to be just and
equitable under all the circumstances, regardless of any technical rule of
law, having in mind the economics of operating any remaining portion of the
Premises and improvements, the cost of restoration, and the balance of the
term remaining, among other relevant considerations.


                          XII. HAZARDOUS MATERIALS

         As used in this Lease, the term "hazardous materials" shall mean any
substance or material which has been determined by the State of California,
the federal government, the City of Hollister, County of San Benito, or any
agency of said governments, to be capable of posing a risk of injury to
health, safety and property including, but not limited to, all of those
materials and substances designated as hazardous or toxic by the Environmental
Protection Agency, the California Water Quality Control Board, the U.S.
Department of Labor, the California Department of Industrial Relations, the
Department of Transportation, the Department of Agriculture, the Consumer
Products Safety Commission, the Department of Health, Education & Welfare, the
Food & Drug Administration or any other governmental agency now or hereafter
authorized to regulate materials and substances in the environment. Without
limiting the generality of the foregoing, the term



                                      28
<PAGE>



"hazardous materials" shall include all of those materials and substances
defined as "toxic materials" in Sections 66680 through 66685 of Title 22 of
the California Administrative Code, Division 4, Chapter 30, as the same may be
amended from time to time.

         Lessee shall promptly comply with all laws related to hazardous
materials, including any and all required monitoring and record keeping, and
any orders of a governmental authority requiring the cleanup and removal of
hazardous materials from the Premises; provided such hazardous materials are
on the Premises as a result of Lessee's actions. If the Premises, or any part
thereof (including the soil, surface water, ground water or the air in or
about the Premises), becomes contaminated by any hazardous material as a
result of Lessee's actions, Lessee shall promptly at its sole cost take all
action necessary to clean up and remove such contamination and restore the
Promises to the condition existing immediately prior to the existence of such
hazardous material in or about the Premises. If the Premises are so
contaminated other than as a result of Lessee's actions, Lessor shall promptly
at its sole cost take all actions necessary to clean up and remove such
contamination and restore the Premises to the condition existing immediately
prior to the existence of such hazardous material in or about the Premises.
Lessee's obligations under this paragraph shall survive Lease termination.
Lessee shall immediately notify Lessor in writing if Lessee causes or permits
any hazardous material to be used or kept in or about the Premises which could



                                      29
<PAGE>



reasonably be expected to give rise to liability if improperly used
or disposed of. Lessee shall be solely responsible far the cost
of any required cleanup and removal of hazardous materials and/or
toxic wastes which have been placed or left upon the Premises by
Lessee after the date of execution of this Lease.

         For (i) any cause of action arising from Lessee's negligence, Lessee
shall indemnify Lessor, and (ii) any cause of action arising from Lessor's
negligence, Lessor shall indemnify Lessee and, in each case, its officers,
directors, affiliated companies (and each of their respective officers and
directors), and hold them harmless from any and all claims, demands,
liabilities, damages, including punitive damages, costs and expenses,
including reasonable attorney's fees, herein collectively referred to as
"Claims" including, but not limited to:

            (1) Any claim by a federal, state or local governmental agency
         arising out of or in any way connected with the environmental condition
         of the Premises including, but not limited to, claims for additional
         cleanup of the Premises; and

            (2) Any claim by a successor in interest of the indemnifying party
         (including a mortgagee who acquires title to the Premises through
         foreclosure or by accepting a deed in lieu of foreclosure), or by any
         subtenant, licensee, or invitee of the indemnifying party arising out


                                      30
<PAGE>


         of or in any way connected with the environmental condition of the
         Premises.

         Notwithstanding any of the foregoing, Lessor shall indemnify Lessee and
its officers, directors, affiliated companies (and each of their respective
officers and directors), successors and assigns against and hold them harmless
from any and all claims, demands, liabilities, damages, including punitive
damages, costs and expenses, including reasonable attorneys' fees, including
but not limited to any claim, whether made by a federal, state or local
governmental agency or otherwise, arising out of or in any way connected with
the environmental condition of the Premises if such claim arises from any
condition or conditions existing on the Premises prior to the date of
execution of this Lease (collectively, "Pre-Existing Conditions") including,
but not limited to, claims for any cleanup of the Premises.

         In order to assist Lessor in assessing its potential liability for any
Pre-Existing Conditions, Lessee has agreed to make timely delivery to Lessor
of all reports prepared by the environmental consulting firm retained by the
Lessee and relating to the Premises. Delivery of such reports to the Lessor is
of the essence of this Lease and is expressly made a condition subsequent to
this Lease. If, within thirty (30) days of receipt of such reports, Lessor
reasonably determines that Lessor's potential liability for any Pre-Existing
Conditions specified in such reports or any other Pre-Existing Conditions
which may exist presents a significant



                                      31
<PAGE>


financial risk which Lessor is unwilling to assume, Lessor may so notify
Lessee in writing at any time during such thirty (30)-day period and,
following receipt of such written notice by Lessee, this Lease shall be
declared a nullity and Lessor shall promptly refund to Lessee all amounts
previously paid by Lessee. Thereafter, neither party shall have any
liabilities or obligations to the other arising out of this Lease. Failure to
deliver such written notice within the prescribed thirty (30)-day period shall
constitute acceptance by the Lessor of all of its obligations hereunder with
respect to the Pre-Existing Conditions.

         Notwithstanding the foregoing, Lessor may, at its option, retain its
own environmental consulting firm to further assist Lessor in assessing its
potential liability for any Pre-Existing conditions and Lessee will, upon
written request, reimburse Lessor for up to One Thousand Dollars ($1,000.00)
of the cost of any reports prepared by such firm; provided copies of such
reports are provided to Lessee. If such reports are delivered to Lessor
subsequent to delivery of the reports prepared at the request of Lessee (but
in no event later than May 30, 1992), the thirty (30)-day period referred to
in the preceding paragraph shall commence upon the receipt of such reports.

         Notwithstanding anything to the contrary, for purposes of this Article
XII, any condition or conditions existing on any parcels of land adjoining the
Premises (which term shall include Parcels 9 and 10 for purposes of this
Article XII) and described in any of


                                      32
<PAGE>



the reports prepared by or for the benefit of Lessor or Lessee pursuant to
this Article XII and delivered to Lessor, including, without limitation, that
certain Phase I Environmental site Assessment dated March 25, 1992, and
prepared by ERM-West, Inc., a copy of which has been provided to Lessor, shall
constitute Pre-Existing Conditions for all purposes of this Lease and
Lessor's indemnification obligations hereunder shall extend to such Pre-Existing
Conditions.


                           XIII. DEFAULT; REMEDIES

A. Lessee's Default.

         1. Introductory Clause. Each of the following events shall be a defauly
by Lessee and a breach of this Lease:

            a. Failure to Materially Perform Lease Covenants. Abandonment of the
Premises or of the leasehold estate, or failure or refusal to pay within
thirty (30) days of when due any installment of rent or any other sum required
by this Lease to be paid by Lessee, or to 'materially perform as required or
conditioned by any other covenant or condition of this Lease.

            b. Attachment or Other Levy. The subjection of any right or interest
of Lessee to attachment, execution, or other levy, or to seizure under legal
process, if not released within one hundred twenty (120) days.

            c. Appointment of Receiver. The appointment of a receiver to take
possession of the Premises or improvements or of Lessee's interest in the
leasehold estate or of Lessee's operations



                                      33
<PAGE>


on the Premises for any reason, including but not limited to, assignment for
benefit of creditors or voluntary or involuntary bankruptcy proceedings, not
released within one hundred twenty (120) days.

            d. Insolvency, Bankruptcy. An assignment by Lessee for the benefit
of creditors or the filing of a voluntary or involuntary petition by or
against Lessee under any law for the purpose of adjudicating Lessee a
bankrupt; or for extending time for payment, adjustment, or satisfaction of
Lessee's liabilities; or for reorganization, dissolution, or arrangement on
account of or to prevent bankruptcy or insolvency; unless the assignment or
proceeding, and all consequent orders, adjudications, custodies, and
supervisions are dismissed, vacated, or otherwise permanently stayed or
terminated within one hundred twenty (120) days after the assignment or
filing.

            e. Default in Mortgage Payment. Default or delinquency in the
payment of any loan secured by a mortgage against Lessee's leasehold after the
expiration or termination of any applicable grace periods.

            f. Lessee's Right to Cure Defaults. If the alleged default is
nonpayment of rent, taxes, or other sums to be paid by Lessee as provided
herein as rent, or elsewhere in this Lease directed to be paid as rent, Lessee
shall have thirty (30) days after written notice is given to cure the default.
For the cure of any other default, Lessee shall promptly and diligently after


                                      34
<PAGE>



the notice commence curing the default and shall have thirty (30) days after
notice is given, to complete the cure plus any additional period that is
reasonably required f or the curing of the default.

            g. Lessor's Right to Cure Lessee's Defaults. After expiration of the
applicable time for curing a particular default, or before the expiration of
that time in the event of emergency, Lessor may at Lessor's election, but is
not obligated to, make any payment required of Lessee under this Lease or
under any note or other document pertaining to the financing of improvements
or fixtures on the Premises, or perform or comply with any covenant or
condition imposed on LesSee under this Lease or any such note or document, and
the amount so paid plus the reasonable cost of any such performance or
compliance, plus interest on such sum at the rate of three percent (3%) over
the Bank of America prime lending rate per year from the date of payment,
performance, or compliance (herein called act), shall be deemed to be
additional rent payable by Lessee with the next succeeding installment of
rent. No such act shall constitute a waiver of default or of any remedy for
default or render Lessor liable for any loss or damage resulting from any such
act.

B. Lessor's Remedies

         1. Introductory Clause. if any default by Lessee shall continue
uncured, following notice of default as required by this Lease, for the period
applicable to the default under the


                                      35
<PAGE>



applicable provision of this Lease, including all applicable cure periods,
Lessor has the following remedies in addition to all other rights and
remedies provided by law or equity, to which Lessor may resort cumulatively
or in the alternative.

         2. Nonmonetary Remedies

            a. Termination. Lessor may at Lessor's election terminate this Lease
by giving Lessee written notice of termination. On the giving of the notice,
all Lessee's rights in the Premises and in all improvements shall terminate.
Promptly after notice of termination, Lessee shall surrender and vacate the
Premises and all improvements in broom-clean condition, and Lessor may reenter
and take possession of the Premises and all remaining improvements and eject
all parties in possession or eject some and not others or eject none; provided
that no subtenant qualifying under nondisturbance provisions of this Lease
shall be ejected. Termination under this paragraph shall not relieve Lessee
from the payment of any sum then due to Lessor or from any claim for damages
previously accrued or then accruing against Lessee.

            b. Reentry Without Termination. Lessor nay at Lessor's election
reenter the Premises, and, without terminating this Lease, at any time and
from time to time relet the Premises and improvements or any part or parts of
them for the account and in the name of Lessee or otherwise. Lessor may at
Lessor's election eject all persons or eject some and not others or eject
none; provided that no subtenant qualifying under nondisturbance


                                      36
<PAGE>


provisions of this Lease shall be ejected. Lessor shall apply all rents from
reletting as in the provision on assignment of subrents. Any reletting may be
for the remainder of the term or for a longer or shorter period. Lessee shall
nevertheless pay to Lessor on the due dates specified in this Lease the
equivalent of all sums required of Lessee under this Lease, plus Lessor's
reasonable expenses, less the avails of any reletting or attornment. No act by
or on behalf of Lessor under this provision shall constitute a termination of
this Lease unless Lessor gives Lessee notice of termination. Lessee shall, in
all events under this subparagraph b., be given credit for any sums collected
on reletting.

            c. Lessee's Personal Property. Lessor may at Lessor's election use
Lessee's personal property and trade fixtures or any of such property and
fixtures without compensation and without liability for use or damage, or
store them for the account and at the cost of Lessee. The election of one
remedy for any one item shall not foreclose an election of any other remedy
for another item or for the same time at a later time.

         3. Monetary Remedies.

            a. Recovery of Rent. Lessor shall be entitled at
Lessor's election to each installment of rent or to any combination
of installments for any period before termination, plus interest
at the rate of three percent (3%) over the Bank of America prime
lending rate per year from the due date of each installment.
Avails of reletting or attorned subrents shall be applied, when


                                      37
<PAGE>


received, as follows: (1) to Lessor to the extent that the avails for the
period covered do not exceed the amount due from and charged to Lessee for
the same period, and (2) the balance to Lessee. Lessor shall make reasonable
efforts to mitigate Lessee's liability under this provision.

            b. Damages. Lessor shall be entitled at Lessor's election to damages
in the following sums: (1) all amounts that would have fallen due as rent
between the time of termination of this Lease and the time of the claim,
judgment, or other award, less the avails of all relettings and attornments
and less all amounts by which Lessor should reasonably have mitigated those
rental losses, plus interest on the balance at the rate of three percent (3%)
over the Bank of America prime lending rate per year; and (2) the "worth" at
the time of the claim, judgment, or other award, of the amount by which the
unpaid rent for the balance of the term exceeds the then fair rental value of
the Premises at the higher of the fair rental value as then encumbered by the
Lease and improvements and the fair rental value unencumbered by the Lease and
improvements. "Worth," as used in this provision, is computed by discounting
the total at the discount rate of the Federal Reserve Bank of San Francisco at
the time of the claim, judgment, or award.

            c. Assignment of Subrents. Lessee assigns to Lessor all subrents and
other sums falling due from subtenants, licensees, and concessionaires (herein
called subtenants) during any period in


                                      38
<PAGE>


which Lessor has the right under this Lease, whether exercised or not, to
reenter the Premises for Lessee's default, and Lessee shall not have any right
to such sums during that period, except as provided in Article XIII, Paragraph
B. 3. a. Lessor may at Lessor's election reenter the Premises and
improvements with notice and process of law, without terminating this Lease,
and either or both collect these sums or bring action for the recovery of the
sums directly from such obligors. Lessor shall receive and collect all
subrents and avails from reletting, applying them: first, to the payment of
reasonable expenses (including attorneys' fees or brokers' commissions or
both; provided said brokers are not affiliated with Lessor or any of its
affiliates) paid or incurred by or on behalf of Lessor in recovering
possession, placing the Premises and improvements in good condition, and
preparing or altering the Premises or improvements for reletting; second, to
the reasonable expense of securing new lessees; third, to the fulfillment of
Lessee's covenants to the end of the term; and fourth, to Lessor's uses and
purposes. Lessee shall nevertheless pay to Lessor on the due dates specified
in this Lease the equivalent of all sums required of Lessee under this Lease,
plus Lessor's reasonable expenses, less the avails of the suns assigned and
actually collected under this provision. Lessor may proceed to collect either
the assigned sums or Lessee's balances or both, or any installment or
installments of them, either before or after expiration of the term, but the
period of limitations shall not


                                      39
<PAGE>


begin to run on Lessee's payments until the due date of the final installment
to which Lessor is entitled nor shall it begin to run on the payments of the
assigned sums until the due date of the final installment due from the
respective obligors.

C. Notice of Lessor's Default; Lessee's Waiver. Lessor shall not be considered
to be in default under this Lease unless (1) Lessee has given notice
specifying the default and (2) Lessor has failed for thirty (30) days to cure
the default, if it is curable, or to institute and diligently pursue
reasonable corrective or ameliorative acts for noncurable defaults. Lessee
shall have the right of termination for Lessor's default only after notice to
all mortgagees under mortgages then existing under provisions of this Lease
relating to purchase or construction of improvements; provided, however, that
Lessee shall only be required to give notice to Lessor's mortgagees if Lessor
has previously provided Lessee with written notice as to the existence of said
mortgagees and their respective addresses for notices.

D. Provisions Applicable to Both Parties.

         1. Unavoidable Default or Delay. Any prevention, delay, nonperformance,
or stoppage due to any of the following causes shall excuse nonperformance for
a period equal to any such prevention, delay, nonperformance, or stoppage,
except the obligations imposed by this Lease for the payment of rent, taxes,
insurance, or obligations to pay money that are treated as rent. The causes
referred to above are: Strikes, lockouts, labor


                                      40
<PAGE>


disputes, failure of power, inability to obtain labor or materials or
reasonable substitutes for either, governmental restrictions or regulations or
controls (except those reasonably foreseeable in connection with the uses
contemplated by this Lease), casualties not contemplated by insurance
provisions of this Lease, or other causes beyond the reasonable control of the
party obligated to perform.

         2. Waiver, Voluntary Acts. No waiver of any default shall constitute a
waiver of any other breach or default, whether of the same or any other
covenant or condition. No waiver, benefit, privilege, or service voluntarily
given or performed by either party shall give the other any contractual right
by custom, estoppel, or otherwise. The subsequent acceptance of rent pursuant
to this Lease shall not constitute a waiver of any preceding default by Lessee
other than default in the payment of the particular rental payment so
accepted, regardless of Lessor's knowledge of the preceding breach at the time
of accepting the rent, nor shall acceptance of rent or any other payment after
termination constitute a reinstatement, extension, or renewal of the Lease or
revocation of any notice or other act by Lessor.

         3. Attorney's Fees. If either party brings any action or proceeding to
enforce, protect, or establish any right or remedy, the prevailing party shall
be entitled to recover reasonable attorney's fees.


                                      41
<PAGE>


                            XIV. WATER TO PREMISES

A. Lessor through the private water system can furnish water to the Premises,
under normal conditions and at Lessee's expense, forty (40) gallons per
minute. An additional forty (40) gallons per minute can be furnished to Parcel
9 if the option to Lease is exercised.

B. If Lessee's water requirements exceed said 40-gallons per minute, Lessee
will be required, at its expense, to construct a water storage tank, or take
other reasonable action necessary, in Lessee's discretion, to increase its
water capacity.


                                  XV. TITLE

A. Title. Lessor covenants that Lessor has good and clear record and marketable
title to the Premises in fee simple absolute, subject to no lesses, tenancies,
agreements, restrictions, encumbrances, liens or defects in title other than
(1) zoning laws and ordinances; and (2) unpaid real estate taxes for the
current fiscal tax year which are not yet due and payable; and (3) all other
items set forth on the preliminary title report, attached hereto marked
Exhibit E, and by this reference incorporated herein.

B. Restrictions. To the best of Lessor's knowledge, Lessor covenants that
there are, at this time, no legal restrictions of any kind whatsoever,
including without limitation, restrictive covenants, zoning ordinances or
regulations which will prevent Lessee from using the Premises for the
construction and operation of a rodent breeding facility and the general
office and


                                      42
<PAGE>

administration activities associated therewith. If any such legal restrictions
are now in existence, Lessee shall have the right to cancel this Lease by
giving written notice to Lessor, in which event this Lease shall terminate as
of the giving of such notice, Lessor shall refund to Lessee the $220,000.00
paid hereunder for the construction of any offsite improvements, and Lessee
shall be under no further obligation to Lessor.

C. No Encumbrances. Lessor covenants that Lessor has full right and lawful
authority to enter into this Lease in accordance with the terms hereof and to
grant the estate demised hereby. Lessor covenants that it will not encumber or
lien the title of the Premises or cause or permit said title to be encumbered
or liened in any manner whatsoever (other than as contemplated by Paragraph E.
of Article III of this Lease), unless (i) Lessor causes to be delivered to
Lessee a non-disturbance agreement satisfactory in form and substance to
Lessee, and (ii) Lessor can provide Lessee with written assurances that such
lien or encumbrance will not prevent Lessee from receiving clear title to the
Premises (which term shall include Parcel 10 and, if applicable, Parcel (9)) on
a timely basis. Lessee may reduce or discharge any encumbrance or lien in
violation of this Paragraph C of Article XV, by payment or otherwise at any
time after giving thirty (30) days' written notice thereof to Lessor and
recover or recoup all costs and expenses thereof from Lessor together with
interest at the rate of the prime rate of Bank of America, as it


                                      43
<PAGE>



may be adjusted from time to time, plus three per centum (3%) per annum, but
in no event greater than the legal rate of centum per annum, but in no event
greater than the legal rate of interest. Such recovery or recoupment may, in
addition to all other remedies, be made by setting off against the amount of
rent payable by Lessee hereunder.

D. Proof of Title. Prior to the delivery by Lessee of an executed copy of this
Lease, Lessor shall furnish Lessee, without cost to Lessee, proof satisfactory
to Lessee that Lessor's title to the Premises is in accordance with the
covenants made in the preceding sections.

E. Quiet Ejoyment. Lessor covenants and agrees with Lessee that upon Lessee
paying the rent required to be paid hereunder and performing and fulfilling
all material covenants, agreements and conditions herein, Lessee shall and
may, at all times during the term of this Lease and all extended terms, if
any, peaceably and quietly have, hold and enjoy the Premises and all rights,
appurtenances and privileges belonging or in any way appertaining thereto
without hindrance or molestation.


                                XVI. EXCHANGE

A. Lessee agrees to cooperate with Lessor in effecting a 1031 exchange in the
event the option to purchase contained herein is exercised.


                                      44
<PAGE>


                             XVII. SUBORDINATION

A. Lease To Be Prior But Subject to Subordination. This Lease is and shall be
prior to any encumbrance now of record and any encumbrance recorded after the
date of this Lease affecting the Premises. At the time of the execution of
this Lease, the holder of any presently existing mortgage relating to the
Premises (which term includes Parcels 9 and 10), or any portion of the
Premises, shall have executed a written agreement, satisfactory in form and
substance to Lessee, agreeing to subordinate the same to this Lease and shall
have filed with the appropriate recording office(s) notice of such
subordination, whereupon this Lease shall have priority over such mortgage. A
copy of such filing shall be given to Lessee. The word "mortgage" as used in
this Article XVII includes mortgages, deeds of trust or other similar
instruments, and any modifications, consolidations, extensions, renewals,
replacements and substitutions thereof. If, however, a lender requires that
this Lease be subordinate to any such encumbrance, this Lease shall be
subordinate to that encumbrance, if Lessor first obtains from the lender a
written agreement, satisfactory in form and substance to Lessee, that provides
substantially the following:

            As long as Lessee performs its obligations under this Lease, said
         lender shall expressly agree that in the event it succeeds to the
         rights of Lessor hereunder, whether by foreclosure or otherwise, said
         lender shall not disturb the possession of Lessee and shall recognize
         Lessee's rights under this Lease, and that notwithstanding such
         succession, this Lease shall continue in full force and effect.


                                      45
<PAGE>


             XVIII. GENERAL CONDITIONS; MISCELLANEOUS PROVISIONS

A. Transactions Between Parties.

         1. Notice

         Definition of notice; application of provision. As used in this Lease,
notice includes but is not limited to the communication of notice, request,
demand, approval, statement, report, acceptance, consent, waiver, and
appointment. No notice of the exercise of any option or election is required
unless the provision giving the election or option expressly requires notice.
Unless the provisions of this Lease on rent direct otherwise, rent shall be
sent in the manner provided for giving notice.

         Writing. All notices must be in writing; provided that no writing other
than the check or other instrument representing the rent payment itself need
accompany the payment of rent.

         Delivery. Notice is considered given on the date shown on the return
receipt from an overnight courier or after deposit in the United States, mail
in a sealed envelope or container, either registered or certified mail, return
receipt requested, postage and postal charges prepaid, addressed by name and
address to the party or person intended as follows:

         Notice to Lessor: HIC ASSOCIATES,
                           a California Joint Venture
                           P.0. Box 721
                           Aptos, CA 95001-0721

                           Attn: Kenneth J. Lindsay


                                      46
<PAGE>



                                     -or-

                           1745 San Felipe Road, Suite 1
                           Hollister, CA 95023

         Notice to Lessee: CHARLES RIVER LABORATORTIES,
                           251 Ballardvale Street
                           Wilmington, MA 01887
                           Attn: Counsel

         Change of recepient or address. Either party may, by notice given at
any time or from time to time, require subsequent notices to be given to
another individual person, whether a party or an officer or representative, or
to a different address, or both. Notices given before actual receipt of notice
of change shall not be invalidated by the change.

         Recipient named. Each recipient named must be an individual person.
If more than one recipient is named, delivery of notice to any one such
recipient is sufficient. If none of the recipients named in the latest
designation of recipient is available for delivery in person, and if the
notice addressed by mail to each recipient named in the latest designation of
recipient is returned to the sender undelivered, notice shall be sufficient it
sent by pail as above to the party as named in this Lease, unless the name or
identity of the party has changed as permitted in this Lease and proper notice
of the change has been given, in which event the notice shall be sufficient if
sent by mail as above to the party named in the latest notice designating the
party, and the notice


                                      47
<PAGE>



is considered given when the first attempt to give notice was properly made.

         2. Performance of Lessee's Covenants by Others. Lessee may at Lessee's
election delegate performance of any or all covenants to any one or more
subtenant, or subtenants of subtenants, and the performance so delegated
shall be deemed Lessee's performance. This provision shall not be considered
to permit or to broaden the right of assignment or subletting beyond the
provisions of this Lease relating to assignment and subletting.

         3. Nonmerger of Fee and Leasehold Estates. If both Lessor's and
Lessee's estates in the Premises or the improvements or both become vested in
the same owner, this Lease shall nevertheless not be destroyed by application
of the doctrine of merger except at the express election of the owner and the
consent of the mortgagee or mortgagees under all mortgages existing under
provisions of this Lease relating to the purchase or construction of
improvements.

         4. Estopppel Certificates; Liquidated Damages. At any time and from
time to time, within ten (10) days after notice of request by either party,
the other party shall execute, acknowledge, and deliver to the requesting
party, or to such other recipient as the notice shall direct, a statement
certifying that this Lease is unmodified and in full force and effect, or, if
there have been modifications, that it is in full force and effect as modified
in the manner specified in the statement. The statement shall also state the
dates to which the rent and any other charges have been


                                      48
<PAGE>



paid in advance. The statement shall be such that it can be relied an by any
auditor, creditor, commercial banker, and investment banker of either party
and by any prospective purchaser or encumbrancer of the Premises or
improvements or both or of all or any part or parts of Lessee's or Lessor's
interests under this Lease.

         5. Joint and Several Obligations. If either Lessor or Lessee consists
of more than one person, the obligation of all such persons is joint and
several.

B. Interpretation of Lease.

         1. Captions, Table of Content.  The table of contents of the Lease and
the captions of the various articles and paragraphs of this Lease are for
convenience and each of reference only and do not define, limit, augment, or
describe the scope, content, or intent of this Lease or of any part or parts
of this Lease.

         2. Gender. The neuter gender includes the feminine and masculine, the
masculine includes the feminine and neuter, and the feminine includes the
neuter, and each includes corporation, partnership, or other legal entity when
the context so requires.

         3. Singular and Plural. The singular number includes the plural
whenever the context so requires.

         4. Exhibits, Agenda. All exhibits and addenda to which reference is
made in this Lease are incorporated in the Lease by the respective references
to them, whether or not they are actually attached, provided they have been
signed or initialed by the


                                      49
<PAGE>


parties. Reference to "this Lease" includes matters incorporated by reference.

         5. Entire Agreement. This Lease contains the entire agreement between
the parties. No promise, representation, warranty, or covenant not included in
this Lease has been or is relied on by either party. Each party has relied on
his own examination of this Lease, the counsel of his own advisors, and the
warranties, representations, and covenants in the Lease itself.

         6. Severability. The invalidity or illegality of any provision shall
not affect the remainder of the Lease.

C. Successors. Subject to the provisions of this Lease an assignment and
subletting, each and all of the covenants and conditions of this Lease shall
he binding on and shall inure to the benefit of the successors, executors,
administrators, assigns, and personal representatives of the respective
parties.


                         XIX. EXPIRATION; TERMINATION

A. Lessee's Duty to Surrender. At the expiration or earlier termination of the
term, Lessee shall surrender to Lessor the possession of the Premises.
Surrender or removal of improvements, fixtures, and trade fixtures shall be as
directed in provisions of this Lease on ownership of improvements at
termination. Notwithstanding other provisions of this Lease, all trade
fixtures shall be removable. Lessee shall leave the surrendered Premises and
any other property in good and broom-clean condition except as provided to the
contrary in provisions of this Lease on maintenance


                                      50
<PAGE>


B. Recordation of Memorandum of Lease. Simultaneously with the delivery of
this Lease, the parties have delivered a short-form Memorandum of Lease which
Lessor shall record in the public office (s) in which such Memorandum is
required to be filed in order to put third parties an notice. If this Lease
is terminated before the expiration of its term, the parties shall execute,
deliver and record an instrument acknowledging such fact and the date of
termination of this Lease.

         IN WITNESS WHEREOF, this Lease is executed on June 5th, 1992, at
Hollister, California.


                                             HIC ASSOCIATES,
                                             A California Joint Venture


                                             By /s/ KENNETH J. LINDSAY
                                               ---------------------------------
                                               KENNETH J. LINDSAY


                                             By /s/ PATRICIA L. LINDSAY
                                               ---------------------------------
                                               PATRICIA L. LINDSAY


                                             By /s/ PAUL W. BERTUCCIO
                                               ---------------------------------
                                               PAUL W. BERTUCCIO


                                             By /s/ TINA BERTUCCIO
                                               ---------------------------------
                                               TINA BERTUCCIO

                                                                      Lessor


                                             CHARLES RIVER LABORATORIES, INC.



                                             By /s/ JAMES C. FOSTER
                                               ---------------------------------
                                               JAMES C. FOSTER, President and
                                                 Chief Executive Officer

                                                                      Lessee



<PAGE>

                        COMMONWEALTH OF MASSACHUSETTS

County of Middlesex, ss.                                    June __, 1992

On this day of June, 1992, before me personally
appeared the above-named James C. Foster, being the President
and Chief Executive Officer of Charles River Laboratories, Inc.,
personally known to me and known by me to be the person whose
name is subscribed to the attached instrument, and acknowledged
that he executed the same for the purposes therein contained on
behalf of Charles River Laboratories, Inc. as his free act and
deed, before me.


                                             -----------------------------------
                                             Notary Public
                                             Commission expires Nov. __, 1992




<PAGE>


STATE OF CALIFORNIA )
                    )
County of San Benito)

On June 5, 1992, before me, Christine Scaglione, a Notary Public in and for
said State, personally appeared Kenneth J. Lindsay and Patricia L. Lindsay and
Paul W. Bertuccio and Tina Bertuacio, personally known to me (or proved to me
on the basis of satisfactory evidence) to be the person(s) whose name(s)
is/are subscribed to the within instrument and acknowledged to me that
he/she/they executed the same in his/her/their authorized capacity(ies), and
that by his/her/their signature(s) on the instrument the person(s), or the
entity upon behalf of which the person(s) acted, executed the instrument.


WITNESS my hand and official seal.


                                             OFFICIAL SEAL
                                             CHRISTINE SCAGLIONE
                                             NOTARY PUBLIC - CALIFORNIA
Signed /s/ CHRISTINE SCAGLIONE               SAN BENITO COUNTY
     ------------------------------          My Comm. Expires. Nov. 13, 1992
           CHRISTINE SCAGLIONE

<PAGE>



                                  EXHIBIT A
                             (Legal Description)
<PAGE>
GRAPHIC OMITTED

                                   PARCEL MAP

       LYING IN THE UNINCORPORATED TERRITORY OF THE COUNTY OF SAN BENITO
     BEING A PORTION OF HOMESTEAD LOT 5 OF THE RANCHO SAN JUSTO SUBDIVISION

<PAGE>


F
                                                             November 14, 1991

                                   PARCEL

All that real property situated in the County of San Benito, State of
California,  being a part of Parcel "B" as shown on that Parcel Map filed
for record in Book 7 of Parcel Maps, Page 35, San Benito County Records; being
more particularly described as follows:

Beginning at the southeast corner of that certain 15.684 acre parcel of land
designated as Parcel "B" as shown on that Parcel Map filed for record in Book
7 of Parcel Maps, Page 35, San Benito County Records; Thence from said point
of beginning, North 2 degrees 17' 40" East, 328.81 feet; Thence North 86
degrees 44' 20" West, 476.44 feet; Thence South 2 degrees 32' 57" West, 323.35
feet; Thence South 86 degrees 05' 10" East, 478.00 feet to the point of
beginning, containing 3.572 acres more or less.

Together with an easement for purposes of public utilities, water, sewer and
storm, lying adjacent to and southerly twenty (20) feet of a line being more
particularly described as follows:

Beginning at a point which bears South 2 degrees 17' 40" West, 323.50 feet
from the north east corner of that certain 15.684 acre parcel of land
designated Parcel "B" as shown upon that Parcel Map filed for record in Book 7
of Parcel maps, Page 35, San Benito County Records; Thence North 86 degrees
44' 20" West, 476.44 feet to the point of terminus.

Also, together with a sanitary sewer line easement over and under a strip of
land 25 feet in width lying adjacent to and easterly of a line being more
particularly described as follows:

Beginning at a point on the south line of Parcel "B" as shown on that Parcel
Map filed for record in Book 7 of Parcel Maps, Page 35, San Benito County
Records; which bears North 86 degrees 05' 10" East, 478.00 feet from the
southeast corner thereof; Thence from said point of beginning, North 2 degrees
32' 57" East, 323.35 feet to the point of terminus.

Also, together with a roadway easement across that certain area scribed by the
arc of a fifty (50) foot radius, the center of the radii being the following
described point: Beginning at a point which bears North 86 degrees 44' 20" West,
475.00 feet and South 2 degrees 32' 57" West, 232.48 feet from the north east
corner of Parcel "B" of the aforementioned Parcel Map.


                                         EXHIBIT "A"                 Page 2 of 3




<PAGE>


                                                             November 14, 1991

                                  PARCEL 10

All that real property situated in the County of San Benito, State of
California, being a part of Parcel "B" as shown on that Parcel Map filed for
record in Book 7 of Parcel Maps, Page 35, San Benito County Records; being
more particularly described as follows:

Beginning at the northeast corner of that certain 15.684 acre parcel of land
designated Parcel "B" as shown on that Parcel Map filed for record in Book 7
of Parcel Maps, Page 35, San Benito County Records; Thence from said point of
beginning, North 86 degrees 44' 20" West, 475.00 feet; Thence South 2 degrees
32' 57" West, 323.48 feet; Thence South 86 degrees 44' 20" East, 476.44 feet;
Thence North 2 degrees 71' 40" East, 323.50 feet to the point of beginning,
containing 3.532 acres more or less.

Together with a sanitary sewer line easement over and under a strip of
land 25 feet in width lying adjacent to and easterly of a line being more
particularly described as follows:

Beginning at a point on the north line of Parcel "B" as shown upon that Parcel
Map filed for record in Book 7 of Parcel Maps, Page 35, San Benito County
Records; which bears North 86 degrees 44' 20" West, 475.00 feet from the
northeast corner thereof; Thence from said point of beginning, South 2 degrees
32' 57" West, 323.48 feet to the point of terminus.

Also, together with a roadway easement across that certain area scribed by the
arc of a fifty (50) foot radius, the center of the radii being the following
described point: Beginning at a point which bears North 86 degrees 44' 20" West,
475.00 feet and South 2 degrees 32' 57" West, 232.48 feet from the north east
corner of Parcel "B" of the aforementioned Parcel Map.


                                         EXHIBIT "A"                Page 3 of 3


<PAGE>



                                  EXHIBIT B

                             COMMON AREA EXPENSES

Common Area expenses shall include payment and maintenance of the following:

1.   Property Taxes and Special Assessments
2.   Insurance
3.   Storm Water Perculation Pond (Lot 8):
     - Maintenance of pond
     - Landscaped areas and fencing around pond
4.   Utilities:
     - Underground and overhead electrical, gas, and telephone apparatus (if not
       covered by utility companies)
5.   Roadways: San Felipe Road frontage and Park Center Drive (entry road):
     - Street, curb, gutter, sidewalk, storm drain lines, sewer lines, water
       lines and systems, street lights, required signage, and entry monuments


<PAGE>


                                  EXHIBIT C

                        (Offsite Development Expenses)

     Charles River Laboratories Facility to pay for the installation of the
following offsite improvements per plans and specifications prepared by
Grimsley & Associates, pages dated: Page 1-4/91; Page 2-8/90; Page 3-8/90;
Page 4-2/89; Rev. 12/10/91; Page 5-2/89; Page 6-4/91; and Page 7-11/91: Lot
#10: $220,000 lump sum payment.

1.   Road extension including curb, gutter and sidewalk.

2.   Extension of private water service, including 1" meter, to the site.

3.   Expansion of storm drain facilities and extension of storm transmissions
     lines to site.

4.   Sewer transmission facilities to site for future hook-up to City services
     (additional costs may be assessed at times of hook-up for connection
     extensions to City facilities and associated fees).

5.   Extension of water facilities for use as fire suppressant and future City
     service, to be connected to existing county supplied, non-potable, San
     Felipe Water system and stubbed to site.

6.   Extension of utility services to site including electric, natural gas, and
     telephone, to terminate at a splice box on site.

The above offsite improvements shall be installed in conjunction with Lessee's
development of the onsite improvements, or within two (2) years, whichever
occurs first.


<PAGE>



                                  EXHIBIT D

                          (Plans and Specifications)


<PAGE>


                                   PROJECT
                                    MANUAL



                                CRL HOLLISTER
                          HIGHWAY INDUSTRIAL CENTER
                            HOLLISTER, CALIFORNIA



                                     FOR



                      CHARLES RIVER LABORATORIES, INC.



                                April 10, 1992



                            HABITEC JOB NO. 9129-1





                                 EXHIBIT "D"
<PAGE>


Standard Parking    =  73 stalls
Handicapped Parking =   1 stall
                       --
                       74 stalls

Parking Ratio       =  1/204
Building Code       =  1988 U.B.C.
Building Type       =  Type V-N
Occupancy           =  B2

                                 SEE ATTACHED
                               PERTINENT PAGES



                                     LOGO
                            ARCHITECTURE PLANNING
                               INTERIOR DESIGN

                        909 Coleman Avenue, Suite 202
                   San Jose, California 95110 406/977-0606

- --------------------------------------------------------------------------------
                                             Lab/Prod
                    As Built       Date       Aprvd.        Date
   TRIANGLE    -------------------------------------------------
               Dwn. by    Date
                                         Revision Description
               Chkd. by   Aprvd. by
- --------------------------------------------------------------------------------


                                Charles River
                              LABORATORIES, INC.
                       WILMINGTON, MASSACHUSETTS 01887

                                 CONFIDENTIAL

This document and all information set forth therein, whether illustrated or
otherwise disclosed or suggested, is proprietary and confidential to Charles
River Laboratories, Inc. and may not be copied, reproduced by any means, or
disclosed by the party who receives this document to any other party, without
prior written permission from Charles River Laboratories, Inc. This document
is on loan from Charles River Laboratories, Inc. and must be immediately
returned on demand.


Title:         CRL HOLLISTER

lOCATION:      HIGHWAY INDUSTRIAL
               CENTER

- -------------------------------------------------------------------------------
As Built:                Date:               Lab/Prod.                Date:
                                             Aprvd.
- -------------------------------------------------------------------------------

Dwn. by: JPS        Scale:                             Date: 4/15/92

- -------------------------------------------------------------------------------

Chkd. by:           Aprvd. by:                         Sheet: of

- -------------------------------------------------------------------------------
Dwg. no.: E.-HCI-AO

- -------------------------------------------------------------------------------



<PAGE>


                   EXHIBIT "D" - Pertinent Pages of Specs

E HCI -   Cl through C3
          Al throucjh A14
          Sl through S10
          El through E11
          Ml through M16
          P1 through P6
          L1 through L2


<PAGE>


                                  EXHIBIT E

                          (Preliminary Title Report)



<PAGE>






                                        Issuing Office:
SUPPLEMENTAL REPORT                     CHICAGO TITLE INSURANCE COMPANY
                                        535 Monterey Street
                                        Hollister, California 95023
                                        (408) 637- 7441


KEN LINDSAY
1745 SAN FELIPE ROAD #1
HOLLISTER, California 95023


                                        Your Ref: APN #019-030-017 & 019-030-018
                                        Order No: 22199  - HRW
                                        Escrow Officer- Christine M. Scaglione


- --------------------------------------------------------------------------------

Dated as of April 22, 1992                   at 7:30 A.M.



- --------------------------------
Title Officer: Harold R. Wishard


The above numbered report (including any supplements or amendments thereto)
is hereby modified and/or supplemented in order to reflect the following:




                                 EXHIBIT "E"



<PAGE>


                                  SCHEDULE A

1. The estate or interest in the land hereinafter described or referred to
covered by this report is:

A FEE











2. Title to said estate or interest at the date hereof is vested in: HIC
ASSOCIATES, A CALIFORNIA J0INT VENTure, A GENERAL PARTNERSHIP

3. The land referred to in this report is situated in the State of California
County of SAN BENITO and is described as follows:

All that certain real property in the County of San Benito, State of California,
described as follows:

Parcels "A" and "B" are shown on that certain Parcel map, filed for record
September 16, 1987, in Book 7 of Parcel Maps, at Page 35, Recorder's file No.
8706859, San Benito County Records.


<PAGE>


                                 SCHEDULE B

At the date hereof exceptions to coverage in addition to the printed
Exceptions and Exclusions in the policy form designated on the face page of
this Report would be as follows:

A    1.   Taxes for the fiscal year 1992-93, a lien not yet payable.

B    2.   The Lien of Supplemental Taxes, if any, assessed pursuant to the
          provisions of Chapter 3-5, (commencing with Section 7S) of the Revenue
          and Taxation Code of the State of California.

C    3.   An easement affecting the portion of said land and for the purposes
          stated herein, and incidental purposes,

          In Favor Of:     Coast Counties Gas and Electric Company
          For:             Single pole line
          Recorded:        September 20, 1943 in Book 123 at Page 230 Official
                           Records
          Affects:         The South 10 feet and the East 10 feet of Parcel "B"

D    4.   An easement affecting the portion of said land and for the purposes
          stated herein, and incidental purposes,

          In Favor Of:     Richard Caporale and Noel Caporale, his wife, as
                           joint tenants
          For:             Pipe line
          Recorded:        November 30, 1954 in Book 209 at Page 309 Official
                           Records
          Affects:         The East end of the land herein, the exact location
                           and width of said easement is not disclosed of
                           record.

E 5.  A   covenant and Agreement

          Executed By:     Arnold Sisco and Mary Sirco, his wife, and Richard
                           Caporale and Noel Caporale, his wife
          In Favor of:     none shown
          Recorded:        November 30, 1954 in Book 209 at Page 309 of Official
                           Records

     Which, among other things provides: The installation, maintenance and usage
of said pipeline

F    6.   The fact that the ownership of said land does not include any right of
          ingress or egress to or from the highway contiguous thereto, said
          right having been relinquished by deed

          To: State of California


<PAGE>


                                  SCHEDULE B
                                 (continued)

          Recorded:        September 7, 1955 in Book 216 at Page 533 of Official
                           Records
          Affects:         That portion of the land herein bordering on San
                           Felipe Road and the Adjacent frontage road

G    7.   An easement affecting the portion of said land and for the purposes
          stated herein, and incidental purposes,

          In Favor Of:     Pacific Gas and Electric Company, a California
                           corporation
          For:             Underground main of pipeline
          Recorded:        October 31, 1956 in Book 227 at Page 352 Official
                           Records
          Affects:         A strip of the uniform width of 10.00 feet which
                           crosses said premises and liens equally on each side
                           of a centerline described as described as follows to
                           wit: Beginning at a point in the Southwesterly
                           boundary line of said premises distant thereon
                           Southeasterly 5 feet from the intersection thereof
                           with the Southeasterly boundary line of the State
                           Highway extending along the Northwesterly boundary
                           line of said premises and running thence parallel
                           with the Southeasterly boundary line of said State
                           Highway North 2 deg. 35' 30" East 65.73 feet; thence
                           North 3 deg. 24' 19" East 364.80 feet, thence
                           Northeasterly and curving to the right (along the arc
                           of a circle of a 350 foot radius) 129.33 feet, thence
                           Northeasterly and curving to the left (along the arc
                           of a circle of a 377 foot radius) 96.28 feet, more or
                           less, to a point in the Northeasterly boundary line
                           of said premises.

H    8.   A matter affecting the portion of said land for the purposes stated
          herein, and incidental purposes, shown or dedicated by the map herein
          referred to:

          For:             30 foot right of way
          Affects:         Parcel "A"

I.   9.   A matter affecting the portion of said land for the purposes stated
          herein, and incidental purposes, shown or dedicated by the map herein
          referred to:

          For:             Clear Zone Avigation


<PAGE>



                                  SCHEDULE B
                                 (continued)

          Affects:         Parcels "A" and "B"

J    10.  A matter affecting the portion of said land for the purposes stated
          herein, and incidental purposes, shown or dedicated by the map herein
          referred to:

          For:             10 foot public utility
          Affect:          West boundary Parcel "A" and "B" and South boundary
                           of Parcel "A"

K    11.  An easement affecting the portion of said land and for the purposes
          stated herein, and incidental purposes,

          In Favor Of:     Hollister, a municipal corporation
          For:             Clear Zone Avigation
          Recorded:        January 23, 1987 as Instrument No. 8700618 in Book
                           n/a at Page n/a Official Records
          Affects:         Parcel "A" and "B"

L    12.  An Agreement, affecting said land, for the purposes, stated herein,
          upon the terms, covenants and conditions referred to therein, between
          the parties named herein

          For:             Clear Zone Avigation
          Dated:           August 1, 1985
          Executed By:     Paul W. Bertuccio and wife Concette, (hereinafter
                           referred to as "Grantor") and the City of Hollister,
                           a municipal corporation of the State of California,
                           (hereinafter referred to as "Grantee")
          Recorded:        January 23, 1987 an Instrument No. 8700618 in Book
                           n/a at Page n/a of Official Records
          Affects:         Parcel "A" and "B"

M    13.  A Deed of Trust to secure an indebtedness of the amount stated
          herein, and any other obligations secured thereby

          Dated:           July 18, 1988
          Amount:          $530,000.00
          Trustor:         HIC Associates, A California Joint Venture
          Trustee:         Fidelity National Title Insurance Company, a
                           California corporation
          Beneficiary:     The Equitable Life Assurance Society of the United
                           States, a New York Corporation


<PAGE>


                                   SCHEDULE
                                 (continued)

          Recorded:        July 29, 198 in Book n/a at Page n/a of official
                           Records
          Instrument No.:  8805442
          Return Address:  2700 Ygnacio Valley Road, Ste. 315, Walnut Creek,
                           CA 94598
          Loan No.:        None shown

N        Said matter affects: Parcel B

O    14.  A Deed of Trust to secure an indebtedness of the amount stated herein,
          and any other obligations secured thereby

          Dated:           August 8, 1989
          Amount:          $550,000.00
          Trustor:         HIC Associates, A California Joint Venture
          Trustee:         Fidelity National Title Insurance Company of
                           California, a California corporation
          Beneficiary:     The Equitable Life Assurance Society of the United
                           States, A New York Corporation
          Recorded:        August 17, 1989 in Book n/a at Page n/a of
                           Official Records
          Instrument No.:  8907206
          Return Address:  2700 Ygnacio Valley Road, Suite 315, Walnut Creek,
                           CA 94598
          Loan No.:        None shown

P         Said matter affects: Parcel A

Q    15.  An unrecorded lease, affecting the premises herein stated, executed
          by and between the parties named herein, for the term and upon the
          terms, covenants and conditions therein provided,

          Dated.           July 26, 1988
          Lessor:          HIC Associates, Inc.
          Lessee:          Lindsay Associates, Inc.
          Disclosed By:    Subordination Agreement
          Recorded:        July 29, 1988 as Instrument No. 8805443 in Book n/a
                           at Page n/a of Official Records
          Effects:         Parcel "B"

R         No representation is made as to the present ownership of said
leasehold or matters affecting the rights or interests of the lessor or lessee
arising out of or occasioned by said lease.


<PAGE>



                                  SCHEDULE B
                                 (continued)

S         Said Deed of Trust has been subordinated to the subject matter
          referred to in this paragraph, by the provisions of an instrument

          Dated:           July 31, 1990
          Executed By:     HIC Associates and Lindsay Associates, Inc.
          Recorded:        August 9, 1990 as Instrument No. 9006852 in Book n/a
                           at Page n/a of Official Records
          Subordinated To: item #16 below

T    16.  An unrecorded lease, affecting the premises herein stated, executed by
          and between the parties named herein, for the term and upon the
          terms, covenants and conditions therein provided,

          Dated:           July 26, 1980
          Lessor:          HIC Associates
          Lessee:          Bertuccio Equipment Sales
          Disclosed By:    Subordination Agreement
          Recorded:        July 29, 1988 as Instrument No. 8805444 in Book
                           n/a at Page n/a of Official Records
          Affects:         Parcel "B"

U.        No representation is made as to the present ownership of said
          leasehold or matters affecting the rights or interests of the lessor
          or lessee arising out of or occasioned by said lease.

V.        Said Deed of Trust has been subordinated to the subject matter
          referred to in this paragraph, by the provisions of an instrument

          Dated:           July 31, 1990
          Executed By:     HIC Associates, and Bertuccio Equipment Sales
          Recorded:        August 9, 1990 as Instrument No. 9006851 in Book
                           n/a at Page n/a of Official Records
          Subordinated To: item #16 below

W    17.  An easement affecting the portion of said land and for the purposes
stated herein, and incidental purposes,

          In Favor Of:     Pacific Gas and Electric Company, a California
                           corporation
          For:             Above ground and underground facilities
          Recorded:        April 4, 1990 as Instrument No. 9002755 in Book
                           n/a at Page n/a Official Records
          Affects:         North boundary of Parcel "A"



<PAGE>

                                  SCHEDULE B
                                 (continued)

X    18.  A Deed of Trust to secure an indebtedness of the amount stated herein,
          and any other obligations secured thereby

          Dated:           July 26, 1990
          Amount:          $600,000.00
          Trustor:         HIC Associates, A California Joint Venture, a general
                           partnership
          Trustee:         Ticor Title Insurance Company of California, a
                           California corporation
          Beneficiary:     The Equitable Life Assurance Society of the United
                           States, A New York Corporation
          Recorded:        August 9, 1990 in Book n/a at Page n/a of Official
                           Records
          Instrument No.:  9006850
          Return Address:  None shown
          Loan No.:        None shown

Y         END OF SCHEDULE B

Z         JRO/mac

          2nd Supplemental

          short term rate

AA   NOTE 1: Title of the vestee herein was acquired by deed recorded prior
     to six months from the date hereof.

AB   NOTE 2: On or after July 1, 1985, the County Recorder's office will
     charge, in addition to the regular recording charges, an extra $20.00
     recording fee, unless a document evidencing a change of ownership is
     accompanied by a Preliminary Change of Ownership Report. In lieu of said
     report, signed by the tranferee, the recorder will accept an affidavit
     that the transferee is not a resident of California. Title billings will
     be adjusted to reflect such additional fees when applicable.

AC   NOTE 3: CALIFORNIA "GOOD FUNDS" LAW

     EFFECTIVE JANUARY 1, 1990, CALIFORNIA INSURANCE CODE SECTION 12413.1,
     (CHAPTER 598, STATUTES OF 1989), PROHIBITS A TITLE INSURANCE COMPANY,
     CONTROLLED ESCROW COMPANY, OR UNDERWRITTEN TITLE COMPANY FROM DISBURSING
     FUNDS FROM AN ESCROW OR SUB-ESCROW ACCOUNT, (EXCEPT FOR FUNDS DEPOSITED
     BY WIRE TRANSFER, ELECTRONIC PAYMENT OR CASH) UNTIL THE DAY THESE FUNDS
     ARE MADE AVAILABLE TO THE DEPOSITOR PURSUAINT TO PART 2239 OF TITLE 12
     OF THE CODE OF FEDERAL REGULATIONS, (REG. CC). ITEMS SUCH AS CASHIER'S,
     CERTIFIED OR TELLERS CHECKS MAY BE AVAILABLE FOR DISBURSEMENT ON THE



<PAGE>


                                  SCHEDULE B
                                 (continued)

     BUSINESS DAY FOLLOWING THE BUSINESS DAY OF DEPOSIT; HOWEVER, OTHER FORMS
     OF DEPOSITS MAY CAUSE EXTENDED DELAYS IN CLOSING THE ESCROW OR SUB-ESCROW.

     CHICAGO TITLE COMPANY WILL NOT BE RESPONSIBLE FOR ACCUALS OF INTEREST
     OR OTHER CHARGES RESULTNG FROM COMPLIANCE WITH THE DISBURSEMENT
     RESTRICTIONS IMPOSED BY STATE LAW.

AD   NOTE 4: The policy or policies, when approved for issuance, will contain
     one of the following exclusions either in its preprinted exclusions or by
     endorsement.

     Loan Policy Exclusion:

     Any claim, which arises out of the transaction creating the interest of
     the mortgage insured by this policy, by reason of the operation of
     federal bankruptcy, state insolvency, or similar creditors' rights laws.

     Owners Policy Exclusion:

     Any claim, which arises out of the transaction vesting in the insured,
     the estate or interest insured by this policy, by reason of the operation
     of federal bankruptcy, state insolvency, or similar creditors' rights
     laws.

AE   NOTE 5: For informational purposes, the General and Special Taxes and
     Assessments, if any, for the fiscal year 1991-1992

     Assessment No.:       19-030-17
     Code No.:             67-003
     First Installment:    $5,411.47 PAID
     Second Installment:   $5,411.47 PAID
     Assessment Valuation Of
     Personal Property:    NONE
     Homeowner Exemption:  None

AF   NOTE 6: For informational purposes, the General and Special Taxes and
     Assessments, if any, for the fiscal year 1991-1992

     Assessment No.:       19-030-18
     Code No.:             67-003
     First Installment:    $6,450.23 PAID
     Second Installment:   $6,450.23 PAID
     Assessment Valuation Of
     Personal property:     NONE
     Homeowner Exemption:  None


                                      73
<PAGE>


                          GRIMSLEY & ASSOCIATES INC.

                          -------------------------

                                CIVIL ENGINEER

                             HOLLISTER CALIFORNIA


                                   PARCEL MAP


       LYING IN THE UNINCORPORATED TERRITORY OF THE COUNTY OF SAN BENITO
     BEING A PORTION OF HOMESTEAD LOT 5 OF THE RANCHO SAN JUSTO SUBDIVISION




<PAGE>

                       ASSIGNMENT AND ASSUMPTION OF LEASE

         This Assignment of Lease is entered into this 22 day of December,
1993, by and between Charles River Laboratories, Inc., a Delaware partnership
("Assignor") and WILMINGTON PARTNERS L.P., a Delaware limited partnership
("Assignee").

         Assignee is acquiring substantially all of the domestic operating
assets of Assignor. For and in consideration of the mutual agreements herein,
and other good and valuable consideration, Assignor hereby assigns to
Assignee, and Assignee accepts from Assignor, all of Assignor's right, title
and interest in and to the lease dated June 5, 1992, by and between HIC
Associates, as Landlord, and Assignor, as Tenant, for the premises located at
1000 Park Center Drive, (Parcel 10), Hollister, California 95023 (the "Lease")
and as more particularly described therein.

         Assignee hereby assumes the obligations of Assignor with respect to
the Lease, and agrees to pay the rents provided in the Lease and to perform
and keep all the terms, covenants and conditions therein contained to be
performed and kept by the Tenant.

         The Assignment shall be effective the date hereof.


Assignor:                                    Assignee:

CHARLES RIVER LABORATORIES, INC.             WILMINGTON PARTNERS L.P.

                                             By: Wilmington Management Corp.,
                                                 General Partner

By: /s/ Alan H. Resnick                      By: /s/ Alan H. Resnick
   -------------------------------              -------------------------------
   Alan H. Resnick                              Alan H. Resnick
   Vice President                               Vice President




                                                                  Exhibit 12.1

Charles River Laboratories, Inc.
Computation of Ratio of Earnings to Fixed Charges
(In millions, except ratio data)

<TABLE>
                                                                                                                 Pro Forma
                                                                                                           ------------------------
                                                                                 Nine Months  Nine Months  Fiscal Year  Fiscal Year
                                                                                    Ended        Ended        Ended        Ended
                               12/31/94  12/30/95  12/28/96  12/26/97  12/26/98  09/26/1998   09/25/1999     12/26/98     12/26/98
                               --------  --------  --------  --------  --------  -----------  -----------  -----------  -----------
<S>                            <C>        <C>       <C>       <C>       <C>         <C>         <C>              <C>        <C>
Income before income taxes**   $ 20,822   27,773    26,134    23,839    37,501      29,739      36,855           644        6,862

Fixed charges:
  Interest expense                  464      768       491       501       421         311         207        35,013       28,330
  Amortization of deferred
    financing costs                  --       --        --        --        --          --          --         1,523        1,142
  1/3 rent from operating
    leases                          531      781       981     1,037     1,091         876         921         1,091          921
                               --------   ------   -------    ------    ------      ------      ------        -------------------
  Total fixed charges          $    995    1,549     1,472     1,538     1,512       1,187       1,128        37,627       30,393
                               -----------------------------------------------------------------------        -------------------

Earnings + fixed charges       $ 21,617   29,322    27,606    25,377    39,013      30,926      37,983        38,271       37,255
                               -----------------------------------------------------------------------        -------------------
Ratio of earnings to fixed
  charges                          21.9     18.9      18.8      16.5      25.6        26.1        33.7           1.0          1.2
                               =======================================================================        ===================



**Includes earnings from equity investments less minority interest
</TABLE>



                                                                    Exhibit 12.2

Charles River Laboratories, Inc.
Computation of Ratio of Total Pro Forma Debt to Adjusted EBITDA
(In millions, except ratio data)


                                        Pro Forma
                                    Nine Months Ended
                                    September 25, 1999

Total Debt                              $ 311,128
Adjusted EBITDA                            45,450
                                        ---------
Total Debt to Adjusted EBITDA                 6.8x



                                                                   Exhibit 12.3

Charles River Laboratories, Inc.
Computation of Ratio of Adjusted EBITDA to Cash Interest Expense
(In millions, except ratio data)


                                          Pro Forma           Pro Forma
                                      Fiscal Year Ended   Nine Months Ended
                                             1998         September 25, 1999

Adjusted EBITDA                            $50,642              $45,450
Cash Interest Expense                       35,013               28,330
                                           -------              -------
Adjusted EBITDA to Cash Interest Expense       1.4x                  1.6x


                                        Exhibit 21.1

                                                   Subsidiaries of Charles River

CRL Transaction Company, Inc.



                                                                    EXHIBIT 23.2

                     [Letterhead of PriceWaterhouseCoopers]


                       CONSENT OF INDEPENDENT ACCOUNTANTS

We hereby consent to the use in this Registration Statement on Form S-1 of our
report dated June 30, 1999, except as to Note 2, which is as of September 29,
1999 relating to the financial statements and financial statement schedule of
Charles River Laboratories, Inc., which appear in such Registration Statement.
We also consent to the reference to us under the heading "Independent
Accountants" in such Registration Statement.


/s/ PriceWaterhouseCoopers LLP
Boston, Masssachusetts
January 10, 2000


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