UTEK CORP
N-2/A, EX-10.21, 2000-06-02
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                                LICENSE AGREEMENT

Effective as of March 28, 2000 ("Effective Date") The Johns Hopkins University,
a corporation of the State of Maryland, having a principal place of business at
3400 North Charles Street, Baltimore, MD 21218 (hereinafter referred to as
"JHU") and Zorax, Inc., a Florida Corporation and a wholly owned subsidiary of
UTEK Corporation, a Delaware Corporation, having a principal place of business
at 202 South Wheeler Street, Plant City, Florida 33566(hereinafter the
"Company") agree as follows:

                            ARTICLE 1 -- BACKGROUND

1.1      JHU has an assignment of "Apparatus for the Separation of Cystic
         Parasite Forms From Water", inventors C.J. Shiff and T.K.Graczyk
         ("Invention[s]"), as described in JHU Docket 1304, US Serial
         # 09/006,999, filed 1 /14/98, and any Licensed Patent(s), as
         hereinafter defined, which may issue to such Invention(s).

1.2      JHU has certain technical data and information as herein defined
         ("Technology") pertaining to Invention(s).

1.3      JHU has acquired through assignment all rights, title and interest,
         with the exception of certain retained rights by the United States
         government, in said valuable invention; and

1.4      JHU, as a center for research and education, JHU desires to have the
         Technology and Invention(s) perfected and marketed at the earliest
         possible time in order that products resulting therefrom may be
         available for public use and benefit.

1.5      JHU is interested in licensing PATENT RIGHTS (hereinafter defined) in a
         manner that will benefit the public by facilitating the distribution of
         useful products and the utilization of new methods, but is without
         capacity to commercially develop, manufacture, and distribute any such
         products or methods.

1.6      Company desires a license under said Technology, Invention(s) and
         Licensed Patent(s) to develop, manufacture, use and distribute such
         products and processes throughout the world in all fields of use.

NOW, THEREFORE, in consideration of the foregoing premises and the following
mutual covenants, and other good and valuable consideration, the receipt of
which is hereby acknowledged, and intending to be legally bound hereby, the
parties agree as follows:

                             ARTICLE 2 - DEFINITIONS

2.1      "PATENT RIGHTS" shall mean the U.S. Patent Application Serial No.
         09/006,999, entitled"Apparatus for the Separation of Cystic Parasite
         Forms From Water", inventors C.J. Shiff and T.K.Graczyk and assigned to
         JHU (hereinafter the "PATENT APPLICATION") and the invention disclosed
         and claimed therein, and all continuations, divisions, and reissues
         based thereof, and any corresponding foreign patent applications, and
         any patents, patents of addition, or other equivalent foreign patent
         rights issuing, granted or registered thereon.

2.2      "TECHNOLOGY" means existing technical data and information, including,
         but not limited to, the


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         information contained in the Patent Application pertaining to the
         Invention(s) and provided to the Company whether or not it is of a
         confidential nature.

2.3      "LICENSED PRODUCT(S)" means any product or part thereof in the Licensed
         Field of Use, the manufacture, use or sale of which:

         a.       would constitute, but for the license granted to the Company
                  pursuant to this Agreement, an infringement of a claim of
                  PATENT RIGHTS (infringement shall include, but is not limited
                  to, direct, contributory, or inducement to infringe).

         b.       incorporates any of the Technology.

2.4      "NET SALES", subject to Paragraph 6.5, below, shall mean gross revenues
         and fees billed by Company, AFFILIATED COMPANY and Company's
         sublicensees from the sale of LICENSED PRODUCT(S), whether or not
         assembled (and without excluding therefrom any components or
         subassemblies thereof, whatever their origin and whether or not it
         falls within the scope of a claim), less the following items but only
         insofar as they actually pertain to the disposition of such Licensed
         Product(s) by Company, AFFILIATED COMPANY or Company's sublicensee(s),
         are included in such gross revenue, and are separately billed:

         a.       Import, export, excise and sales taxes, and custom duties;

         b.       Costs of insurance, packaging, and transportation from the
                  place of manufacture to the customer's premises or point of
                  installation;

         c.       Costs of installation at the place of use; and

         d.       Credit for returns, allowances, or trade discounts.

In the event that Company, AFFILIATED COMPANY or Company's sublicensee sells a
LICENSED PRODUCTS) in combination with other ingredients or substances, the NET
SALES for purposes of royalty payments shall be based on the sales revenues and
fees received from the entire combination.

2.5      "AFFILIATED COMPANY" or "AFFILIATED COMPANIES" shall mean any
         corporation, company, partnership, joint venture or other entity which
         controls, is controlled by or is under common control with the Company.
         For purposes of this Paragraph 2.5, control shall mean the direct or
         indirect ownership of at least fifty percent (50%).

2.6      "EXCLUSIVE LICENSE" shall mean a grant by JHU to Company of its entire
         right and interest in the PATENT RIGHTS, subject to rights retained by
         the United States government in accordance with P.L. 96-517, as amended
         by P.L. 98-620, and subject to the retained right of JHU to make, have
         made, provide and use for its' non-profit purposes LICENSED PRODUCT(S).

                               ARTICLE 3 - GRANTS

3.1      Subject to the terms and conditions of this Agreement, JHU hereby
         grants and Company hereby accepts, an EXCLUSIVE LICENSE, with the right
         to sublicense others pursurant to Article 9, to make, have made, use,
         sell, and import the LICENSED PRODUCTS) in the United States and
         worldwide underthe PATENT RIGHTS.


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3.2      Company may sublicense others under this Agreement, subject to Article
         9, and shall provide a copy of each such sublicense agreement to JHU
         promptly after it is executed. Each sublicense shall be consistent with
         the terms of this Agreement.

3.3      JHU shall have the right to practice the Invention(s) and use the
         Technology for its own bona fide research, including sponsored research
         and collaborations. JHU shall have the right to publish any information
         included in Technology and Licensed Patent(s).

                          ARTICLE 4 - GOVERNMENT RIGHTS

This Agreement is subject to all of the terms and conditions of Title 35 United
States Code Sections 200-204, including an obligation that Licensed Product(s)
sold or produced in the United States be "manufactured substantially in the
United States," and Company agrees to take all reasonable action necessary on
its part as licensee to enable JHU to satisfy its obligation thereunder,
relating to Invention(s).

                         ARTICLE 5 - PATENT INFRINGEMENT

5.1      Each party will notify the other promptly in writing when any
         infringement by another is uncovered or suspected.

5.2      Company shall have the first right to enforce any patentwithin PATENT
         RIGHTS against any infringement or alleged infringement thereof, and
         shall at all times keep JHU informed as to the status thereof. Company
         may, in its sole judgment and at its own expense, institute suit
         against any such infringer or alleged infringer and control, settle,
         and defend such suit in a manner consistent with the terms and
         provisions hereof and recover, for its account, any damages, awards or
         settlements resulting therefrom, subject to Paragraph 5.4. This right
         to sue for infringement shall not be used in an arbitrary or capricious
         manner. JHU shall reasonably cooperate in any such litigation at
         Company's expense.

5.3      If Company elects not to enforce any patent within the PATENT RIGHTS,
         then it shall so notify JHU in writing within six (6) months of
         receiving notice that an infringement exists, and JHU may, in its sole
         judgment and at its own expense, take steps to enforce any patent and
         control, settle, and defend such suit in a manner consistent with the
         terms and provisions hereof, and recover, for its own account, any
         damages, awards or settlements resulting therefrom.

5.4      Any recovery by Company under Paragraph 5.2 shall be deemed to reflect
         loss of commercial sales, and Company shall pay to JHU fifteen percent
         (15%) of the recovery net of all reasonable costs and expenses
         associated with each suit or settlement. If the cost and expenses
         exceed the recovery, then one-half (1/2) of the excess shall be
         credited against royalties payable by Company to JHU hereunder in
         connection with sales in the country of such legal proceedings,
         provided, however, that any such credit under this Paragraph 5.4 shall
         not exceed fifty percent (50%) of the royalties otherwise payable to
         JHU with regard to sales in the country of such action in any one
         calendar year, with any excess credit being carried forward to future
         calendar years.

                     ARTICLE 6 - PAYMENTS, ROYALTY, REPORTS

6.1      Company shall reimburse JHU for the reasonable costs of preparing,
         filing, maintaining and prosecuting PATENT RIGHTS incurred after the
         Effective Date of this Agreement. Company shall

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         reimburse JHU within thirty (30) days of receipt of invoice from JHU.

6.2      Company shall pay JHU fifteen thousand dollars ($15,000) within 30 days
         of the Effective Date of this Agreement as the up-front fee for the
         exclusive license to this TECHNOLOGY.

6.3      Company shall pay to JHU earned royalties of two and one half percent
         (2.5%) of NET SALES for the term of this Agreement. Such payments shall
         be made quarterly as provided in Paragraph 6.6.

6.4      Company shall pay the following minimum royalties beginning 24 months
         after the Effective Date:

         6.4.1    3rd anniversary:          $3,000
         6.4.2    4th anniversary:          $3,500
         6.4.3    5th anniversary:          $4,000
         6.4.4    6th anniversary:          $4,500
         6.4.5    7th anniversary and each anniversary thereafter until the end
                  of patent life: $5,000.

6.5      Company shall provide Zorax, Inc common stock equal to 9% of currently
         outstanding shares (as of the Effective Date).

6.5.1    In the event that Zorax is sold. TM will agree to sell their shares to
         the acquirer and in consideration JHU will receive 9% of the total
         consideration issued for all of Zorax's shares.

6.6      The Company shall provide to JHU within thirty (30) days of the end of
         each March; June, September and December after the EFFECTIVE DATE of
         this Agreement, a written report to JHU of the amount of LICENSED
         PRODUCTS sold, the total NET SALES of such LICENSED PRODUCTS and the
         earned royalties due to JHU as a result of NET SALES by Company,
         AFFILIATED COMPANIES and sublicensees thereof. Payment of any such
         royalties due shall accompany such report.

Until the Company, an AFFILIATED COMPANY or a sublicensee has achieved a first
commercial sale of a LICENSED PRODUCT, a report shall be submitted at the end of
every June and December after the EFFECTIVE DATE of this Agreement. Such report
shall include, as a minimum, information sufficient to enable JHU to satisfy
reporting requirements of the US Government and for JHU to ascertain progress by
Company's, AFFILIATED COMPANIES or sublicensee's technical efforts towards
meeting the diligence requirements in Article 8.

6.7      Company shall make and retain, for a period of three (3) years
         following the period of each report required by Paragraph 6.4 true and
         accurate records, files and books of account containing all the data
         reasonably required for the full computation and verification of sales
         and other information required in Paragraph 6.4. Such books and records
         shall be in accordance with generally accepted accounting principles
         consistently applied. The Company shall permit the inspection and
         copying of such records, files and books of account by JHU or its
         agents during regular business hours upon two (2) business days'
         written notice to the Company. Such inspection shall not be made more
         than once each calendar year. All costs of such inspection and copying
         shall be paid by JHU, provided that if any such inspection shall reveal
         that an error has been made in the amount equal to five percent (5%) or
         more of such payment, such costs shall be borne by the Company. The
         Company shall include in any agreement with its AFFILIATED COMPANIES or
         its sublicensees which permits such party to make, use or sell the
         LICENSED PRODUCTS) or provide LICENSED SERVICES, a provision requiring
         such party to retain records of sales of LICENSED PRODUCTS)


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         and records of LICENSED SERVICES and other information as required in
         Paragraph 6.4 and permit JHU to inspect such records as required by
         this Paragraph 6.5.

6.8      In order to insure JHU the full royalty payments contemplated
         hereunder, the Company agrees that in the event any LICENSED PRODUCT
         shall be sold to an AFFILIATED COMPANY or sublicensee or to a
         corporation, firm or association with which Company shall have any
         agreement, understanding or arrangement with respect to consideration
         (such as, among other things, an option to purchase stock or actual
         stock ownership, or an arrangement involving division of profits or
         special rebates or allowances) the royalties to be paid hereunder for
         such LICENSED PRODUCTS shall be based upon the greater of: 1) the net
         selling price at which the purchaser of LICENSED PRODUCTS resells such
         product to the end user, 2) the net service revenue received from using
         the LICENSED PRODUCT in providing a service, 3) the fair market value
         of the LICENSED PRODUCT or 4) the net selling price of LICENSED
         PRODUCTS paid by the purchaser.

6.9      All payments under this Agreement shall be made in U.S. Dollars.

             ARTICLE 7 - PATENT RIGHTS AND CONFIDENTIAL INFORMATION

7.1      JHU, at the Company's expense, shall file, prosecute and maintain all
         patents and patent applications specified under PATENT RIGHTS upon
         authorization of the Company and the Company shall be licensed
         thereunder. Title to all such patents and patent applications shall
         reside in JHU. JHU shall have full and complete control over all patent
         matters in connection therewith under the PATENT RIGHTS. The Company
         will provide payment authorization to JHU at least one (1) month before
         an action is due, provided that the Company has received timely notice
         of such action from JHU. Failure to provide authorization can be
         considered by JHU as a Company decision not to authorize an action. In
         any country where the Company elects not to have a patent application
         filed or to pay expenses associated with filing, prosecuting, or
         maintaining a patent application or patent, JHU may file, prosecute,
         and/or maintain a patent application or patent at its own expense and
         for its own exclusive benefit and the Company thereafter shall not be
         licensed under such patent or patent application.

7.2      Company agrees that all packaging containing individual LICENSED
         PRODUCT(S) sold by Company, AFFILIATED COMPANIES and sublicensees of
         Company will be marked with the number of the applicable patent(s)
         licensed hereunder in accordance with each country's patent laws.

7.3      If necessary, the parties will exchange information which they consider
         to be confidential. The recipient of such information agrees to accept
         the disclosure of said information which is marked as confidential at
         the time it is sent to the recipient, and to employ all reasonable
         efforts to maintain the information secret and confidential, such
         efforts to be no less than the degree of care employed by the recipient
         to preserve and safeguard its own confidential information. The
         information shall not be disclosed or revealed to anyone except
         employees of the recipient who have a need to know the information and
         who have entered into a secrecy agreement with the recipient under
         which such employees are required to maintain confidential the
         proprietary information of the recipient and such employees shall be
         advised by the recipient of the confidential nature of the information
         and that the information shall be treated accordingly. The recipient's
         obligations under this Paragraph 7.3 shall not extend to any part of
         the information:

         a.       that can be demonstrated to have been in the public domain or
                  publicly known and readily available to the trade or the
                  public prior to the date of the disclosure; or


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         b.       that can be demonstrated, from written records to have been in
                  the recipient's possession or readily available to the
                  recipient from another source not under obligation of secrecy
                  to the disclosing party prior to the disclosure; or

         c.       that becomes part of the public domain or publicly known by
                  publication or otherwise, not due to any unauthorized act by
                  the recipient; or

         d.       that is demonstrated from written records to have been
                  developed by or for the receiving party without reference to
                  confidential information disclosed by the disclosing party.

The obligations of this Paragraph 7.3 shall also apply to AFFILIATED COMPANIES
and/or sublicensees provided such information by Company. JHU's, the Company's,
AFFILIATED COMPANIES, and sublicensees' obligations under this Paragraph 7.3
shall extend until three (3) years after the termination of this Agreement.

             ARTICLE 8 - TERM DILIGENCE. MILESTONES AND TERMINATION

8.1      This Agreement shall expire in each country on the date of expiration
         of the last to expire patent included within PATENT RIGHTS in that
         country or if no patents issue seventeen (17) years from the Effective
         Date of this Agreement.

8.2      Zorax has the right to terminate this Agreement with 60 days written
         notice to JHU, providing all monies owed to JHU as of the date of
         notice of Termination have been fully paid to JHU. In the event of
         Termination, all rights to JHU TECHNOLOGY will revert back to JHU.

8.3      As an inducement to JHU to enter into this Agreement, Company agrees to
         use best efforts to proceed with the development, manufacture, and sale
         or lease of Licensed Product(s) and to diligently develop markets for
         the LICENSED PRODUCT(S). To this end, Company shall meet the following
         milestones:

         (A)      Company shall invest at least $30,000 in developing the
                  Technology within the first 12 months after the Execution
                  Date.

         (B)      Company shall supply JHU with a business development plan
                  reasonably acceptable to JHU with concrete product development
                  and marketing milestones delineated within 60 days of the
                  first anniversary of this Agreement. Should company fail to
                  provide such a plan or meet the milestones in the plan, JHU
                  shall have the right to immediately terminate this Agreement.

8.4      After first commercial sale, Company shall exercise its best efforts to
         market a product included in LICENSED PRODUCTS in the U.S. and
         worldwide.

8.5      After evidence, provided in writing by JHU or by another party, to
         Company, demonstrates the practicality of a particular application of
         the Technology which is not being developed or commercialized by
         Company, Company shall either provide JHU with a reasonable development
         plan and start development or attempt to reasonably sublicense the
         particular technology to a third party. If within six (6) months of
         such notification by JHU, Company has not initiated such development
         efforts or sublicensed that particular application of the Technology,
         JHU may terminate this license for such particular application. This
         Paragraph 8.4 shall not be applicable if Company


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         reasonably demonstrates to JHU that commercializing such LICENSED
         PRODUCTS) or granting such a sublicense would have a potentially
         adverse commercial effect upon marketing or sales of the LICENSED
         PRODUCTS developed and being sold by Company.

8.6      Upon breach or default of any of the terms and conditions of this
         Agreement, the defaulting party shall be given written notice of such
         default in writing and a period of sixty (60) days after receipt of
         such notice to correct the default or breach. If the default or breach
         is not corrected within said sixty (60) day period, the party not in
         default shall have the right to terminate this Agreement. Failure to
         meet any of the milestones in paragraph 8.2 shall be considered a
         breach.

8.7      Termination shall not affect JHU's right to recover unpaid royalties or
         fees or reimbursement for patent expenses incurred pursuant to
         Paragraph 7.1 prior to termination. Upon termination all rights in and
         to the licensed technology shall revert to JHU at no cost to JHU.

                       ARTICLE 9 - NEGATION OF WARRANTIES

JHU does not warrant the validity of any patents or that practice under such
patents shall be free of infringement of patents, copyrights, and other rights
of third parties. EXCEPT AS EXPRESSLY SET FORTH IN THIS ARTICLE 9, COMPANY,
AFFILIATED COMPANIES AND SUBLICENSEES AGREE THAT THE PATENT RIGHTS ARE PROVIDED
"AS IS", AND THAT JHU MAKES NO REPRESENTATION OR WARRANTY WITH RESPECT TO THE
PERFORMANCE OF LICENSED PRODUCTS) AND LICENSED SERVICES INCLUDING THEIR SAFETY,
EFFECTIVENESS, OR COMMERCIAL VIABILITY.

JHU DISCLAIMS ALL WARRANTIES WITH REGARD TO PRODUCTS) AND SERVICES LICENSED
UNDER THIS AGREEMENT, INCLUDING, BUT NOT LIMITED TO, ALL WARRANTIES, EXPRESS OR
IMPLIED, OF MERCHANTABILITY AND FITNESS FOR ANY PARTICULAR PURPOSE.

NOTWITHSTANDING ANY OTHER PROVISION OF THIS AGREEMENT, JHU ADDITIONALLY
DISCLAIMS ALL OBLIGATIONS AND LIABILITIES ON THE PART OF JHU AND INVENTORS, FOR
DAMAGES, INCLUDING, BUT NOT LIMITED TO, DIRECT, INDIRECT, SPECIAL, AND
CONSEQUENTIAL DAMAGES, ATTORNEYS' AND EXPERTS' FEES, AND COURT COSTS (EVEN IF
JHU HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES, FEES OR COSTS), ARISING
OUT OF OR IN CONNECTION WITH THE MANUFACTURE, USE, OR SALE OF THE PRODUCTS) AND
SERVICES LICENSED UNDER THIS AGREEMENT. COMPANY, AFFILIATED COMPANIES AND
SUBLICENSEES ASSUME ALL RESPONSIBILITY AND LIABILITY FOR LOSS OR DAMAGE CAUSED
BY A PRODUCT AND SERVICE MANUFACTURED, USED, OR SOLD BY COMPANY, ITS
SUBLICENSEES AND AFFILIATED COMPANIES WHICH IS A LICENSED PRODUCT OR LICENSED
SERVICE AS DEFINED IN THIS AGREEMENT.

Nothing in this Agreement shall be construed as:

2.       an obligation to bring or prosecute actions or suits against third
parties for infringement, except to the extent and in the circumstances
described in Article 12.

3.       Granting, by implication or estoppel, or otherwise any licenses or
rights under patents or other rights of JHU or other persons other than
Licensed Patent(s), regardless of whether such patents or


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         other rights are dominant or subordinate to any Licensed Patent(s); or

4.       An obligation to furnish any technology or technological information
other than the Technology.

                             ARTICLE 9 -- SUBLICENSE

9.1      Company may sublicense others under this Agreement and shall provide a
         copy of each such sublicense agreement to JHU promptly after it is
         executed. Each sublicense shall be consistent with the terms of this
         Agreement.

9.2      If Company is unable or unwilling to serve or develop a potential
         market or market territory for which there is a willing sublicensee(s),
         Company will, at JHU's request, negotiate in good faith a sublicense(s)
         hereunder.

9.3      Any sublicense(s) granted by LICENSEE under this Agreement shall be
         subject and subordinate to terms and conditions of this Agreement,
         except:

         a.       Sublicense terms and conditions shall reflect that any
                  sublicensee(s) shall not further sublicense;

         and


         b.       The earned royalty rate specified in the sublicense(s) may be
                  at higher rates than the rates in this Agreement.

Any such sublicense(s) also shall expressly include the provisions of Articles
17.2. 7.3. 8.4. 8.7 and 9) forthe benefit of JHU and provide for the transfer of
all obligations, including the payment of royalties specified in such
sublicense(s), to JHU or its designee, in the event that this Agreement is
terminated.

9.4      Company must provide JHU with 1.25% royalty on Net Sales of all
         products sold by its sublicensee(s) which incorporate LICENSED
         TECHNOLOGY

                            ARTICLE 10 -MISCELLANEOUS

10.1     All notices pertaining to this Agreement shall be in writing and sent
         certified mail, return receipt requested, to the parties at the
         following addresses or such other address as such party shall have
         furnished in writing to the other party in accordance with this
         Paragraph 10.1:

FOR JHU:  Nina M. Siegler, C.F.A.
          Director, Office of Technology Transfer
          Johns Hopkins University
          708 N. Wyman Park Center
          3400 N. Charles Street
          Baltimore, MD 21218
               Phone: (410) 516-8137
               FAX: (410) 516-7811
               E-mail: [email protected]


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FOR Company: Uwe Reischl, M.D., Ph.D.
             President
             Zorax, Inc.
             202 South Wheeler Street
             Plant City, FI 3566
                  Phone: (813) 654-6113
                  FAX: (813) 754-2383
                  E-mail: [email protected]

10.2     All written progress reports, royalty and other payments, and any other
         related correspondence shall be in writing and sent to:

FOR JHU: Nina M. Siegler, C.F.A.
         Director, Office of Technology Transfer
         Johns Hopkins University
         708 N. Wyman Park Center
         3400 N. Charles Street
         Baltimore, MD 21218
              Phone: (410) 516-8137
              FAX: (410) 516-7811
              E-mail: [email protected]

or such other addressee which JHU may designate in writing from time to time.
Checks are to be made payable to "Johns Hopkins University".

10.3     This Agreement is binding upon and shall inure to the benefit of JHU,
         its successors and assignees and shall not be assignable to another
         party without the written consent of JHU, which consent shall not be
         unreasonably withheld, except that the Company shall have the right to
         assign this Agreement to another party without the consent of JHU in
         the case of the sale or transfer by the Company of all, or
         substantially all, of its assets relating to the LICENSED PRODUCT or
         LICENSED SERVICE, to that party.

10.4     In the event that any one or more of the provisions of this Agreement
         should for any reason be held by any court or authority having
         jurisdiction over this Agreement, or over any of the parties hereto to
         be invalid, illegal or unenforceable, such provision or provisions
         shall be reformed to approximate as nearly as possible the intent of
         the parties, and if unreformable, shall be divisible and deleted in
         such jurisdictions; elsewhere, this Agreement shall not be affected.

10.5     The construction, performance, and execution of this Agreement shall be
         governed by the laws of the State of Maryland.

10.6     The Company shall not use the name of THE JOHNS HOPKINS UNIVERSITY or
         THE JOHNS HOPKINS HEALTH SYSTEM or THE JOHNS HOPKINS SCHOOL OF HYGIENE
         AND PUBLIC HEALTH or any of its constituent parts or any contraction
         thereof or the name of inventors of PATENT RIGHTS in any advertising,
         promotional, sales literature or fundraising documents without prior
         written consent from JHU. Company shall allow at least seven (7)
         business days notice of any proposed public disclosure for JHU's review
         and comment or to provide written consent.

10.7     JHU warrants that it has good and marketable title to its interest in
         the inventions claimed under


<PAGE>



         PATENT RIGHTS with the exception of certain retained rights of the
         United States government.

10.8     JHU and the inventors of LICENSED PRODUCTS) will not, under the
         provisions of this Agreement or otherwise, have control over the manner
         in which Company or its AFFILIATED COMPANIES or its sublicensees or
         those operating for its account or third parties who purchase LICENSED
         PRODUCTS) from any of the foregoing entities, practice the inventions
         of LICENSED PRODUCT(S). Company shall defend and hold JHU, and its
         constituent parts, their present and former regents, trustees,
         officers, inventors of PATENT RIGHTS, agents, faculty, employees and
         students harmless as against any judgments, fees, expenses, or other
         costs arising from or incidental to any product liability or other
         lawsuit, claim, demand or other action brought as a consequence of the
         practice of said inventions by any of the foregoing entities, whether
         or not JHU or said inventors, either jointly or severally, is named as
         a party defendant in any such lawsuit. Practice of the inventions
         covered by LICENSED PRODUCTS) by an AFFILIATED COMPANY or an agent or a
         sublicensee or a third party on behalf of or for the account of Company
         or by a third party who purchases LICENSED PRODUCTS) from the Company,
         shall be considered Company's practice of said inventions for purposes
         of this Paragraph 10.8. The obligation of Company to defend and
         indemnify as set out in this Paragraph 10.8 shall survive the
         termination of this Agreement.

10.9     Prior to first commercial sale of any LICENSED PRODUCT as the case may
         be in any particular country, Company shall establish and maintain, in
         each country in which Company, an AFFILIATED COMPANY or sublicensee
         shall test or sell LICENSED PRODUCT(S), product liability or other
         appropriate insurance coverage appropriate to the risks involved in
         marketing LICENSED PRODUCTS) and will annually present evidence to JHU
         that such coverage is being maintained. Upon JHU's request, Company
         will furnish JHU with a Certificate of Insurance of each product
         liability insurance policy obtained and agrees to increase or change
         the kind of insurance pertaining to the LICENSED PRODUCTS) at the
         request of JHU. JHU shall be listed as an additional insured in
         Company's said insurance policies.

10.10    JHU may publish manuscripts, abstracts or the like describing the
         PATENT RIGHTS and inventions contained therein provided confidential
         information of Company as defined in Paragraph 7.3, is not included or
         without first obtaining approval from the Company to include such
         confidential information. Otherwise, JHU and the inventors shall be
         free to publish manuscripts and abstracts or the like directed to the
         work done at JHU related to the licensed technology without prior
         approval.

10.11    This Agreement constitutes the entire understanding between the parties
         with respect to the obligations of the parties with respect to the
         subject matter hereof, and supersedes and replaces all prior
         agreements, understandings, writings, and discussions between the
         parties relating to said subject matter.

10.12    This Agreement maybe amended and any of its terms or conditions maybe
         waived only by a written instrument executed by the authorized
         officials of the parties or, in the case of a waiver, by the party
         waiving compliance. The failure of either party at anytime or times to
         require performance of any provision hereof shall in no manner affect
         its right at a later time to enforce the same. No waiver by either
         party of any condition or term in any one or more instances shall be
         construed as a further or continuing waiver of such condition or term
         or of any other condition or term.

10.13    This Agreement shall be binding upon and inure to the benefit of and be
         enforceable by the parties hereto and their respective successors and
         permitted assigns.



<PAGE>


IN WITNESS WHEREOF the respective parties hereto have executed this Agreement by
their duly authorized officers on the date appearing below their signatures.


JOHNS HOPKINS UNIVERSITY                    ZORAX, Inc.


By:                                         By:
   ---------------------------------           --------------------------------
Theodore O. Poehler, Ph.D.                  Uwe Reischl, M.D., Ph.D.
Vice Provost for Research                   President

Date:                                       Date:
     -------------------------------             ------------------------------

I have read and agree to abide by the terms of this Agreement

By:                                         By:
   ---------------------------------           --------------------------------


Dr.:                                        Dr.:
    --------------------------------            -------------------------------

Date:                                       Date:
     -------------------------------             ------------------------------






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