ARRAY BIOPHARMA INC
S-1, EX-3.1, 2000-09-15
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<PAGE>   1
                                                                     EXHIBIT 3.1

                               State of Delaware               PAGE 1

                        Office of the Secretary of State

     I, EDWARD J. FREEL, SECRETARY OF STATE OF THE STATE OF DELAWARE, DO HEREBY
CERTIFY THE ATTACHED IS A TRUE AND CORRECT COPY OF THE RESTATED CERTIFICATE OF
"ARRAY BIOPHARMA INC.", FILED IN THIS OFFICE ON THE THIRTY-FIRST DAY OF AUGUST,
A.D. 2000, AT 11:30 O'CLOCK A.M.

     A FILED COPY OF THIS CERTIFICATE HAS BEEN FORWARDED TO THE NEW CASTLE
COUNTY RECORDER OF DEEDS.



                                       /s/ EDWARD J. FREEL
                             [SEAL]    -----------------------------------
                                       Edward J. Freel, Secretary of State

2856233 8100                                       AUTHENTICATION: 0650953

001441765                                                    DATE: 08-31-00


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                                                          STATE OF DELAWARE
                                                         SECRETARY OF STATE
                                                      DEPARTMENT OF CORPORATIONS
                                                       FILED 11.30 AM 08/31/2000
                                                          001441765 - 2856233

                              AMENDED AND RESTATED
                         CERTIFICATE OF INCORPORATION OF
                              ARRAY BIOPHARMA INC.

                       (PURSUANT TO SECTIONS 242 AND 245)

     Array BioPharma Inc., a corporation organized and existing under and by
virtue of the General Corporation Law of the State of Delaware (the
"Corporation"), does hereby certify as follows for the purpose of amending and
restating its Certificate of Incorporation:

     1. The Corporation was originally incorporated under the same name, and the
original Certificate of Incorporation of the Corporation was filed with the
Secretary of State of the State of Delaware on February 6, 1998.

     2. The Board of Directors of the Corporation duly adopted resolutions
containing provisions of this Amended and Restated Certificate of Incorporation
of the Corporation, declaring such amendment and restatement to be advisable and
called for the approval of the stockholders of the Corporation to such amendment
and restatement in accordance with Sections 242 and 245 of the General
Corporation Law of the State of Delaware.

     3. That the holders of at least 66 2/3% of the outstanding shares of the
Corporation's Series A Preferred Stock voting as a single class, 66 2/3% of the
outstanding shares of the Corporation's Series B Preferred Stock voting as a
single class and 50% of the outstanding shares of the Corporation's Common Stock
and Preferred Stock voting as a single class, in each case acting by means of
written consent in lieu of a meeting pursuant to Section 228(a) of the General
Corporation Law of the State of Delaware, adopted and approved this Amended and
Restated Certificate of Incorporation in accordance with Sections 242 and 245 of
the General Corporation Law of the State of Delaware.

     4. That the text of the Corporation's Certificate of Incorporation as
heretofore amended and supplemented is hereby further amended and restated in
its entirety to read as follows:


                                   ARTICLE I
                                      NAME

              The name of the corporation is Array BioPharma Inc.

                                   ARTICLE II
                          REGISTERED OFFICE AND AGENT

          The address of its registered office in the State of Delaware is 1209
Orange Street, in the City of Wilmington, County of New Castle 19801. The name
of its registered agent at such address is The Corporation Trust Company.


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                                   ARTICLE III
                               NATURE OF BUSINESS

          The nature of the business or purposes to be conducted or promoted is
to engage in any lawful act or activities for which corporations may be
organized under the General Corporation Law of the State of Delaware.

                                   ARTICLE IV
                              CAPITAL; SHAREHOLDERS

     4.1 Authorized Capital. The aggregate number of shares that the Corporation
shall have authority to issue is 20,225,000 shares of common stock, each having
a par value of $0.001 (the "Common Stock"), and 11,825,000 shares of preferred
stock, each having a par value of $0.001, 6,800,000 shares of which shall be
designated as Series A Preferred Stock, 3,300,000 shares of which shall be
designated as Series B Preferred Stock and 1,725,000 shares of which shall be
designated as Series C Preferred Stock. The Series A Preferred Stock, Series B
Preferred Stock and the Series C Preferred Stock is sometimes collectively
referred to herein as the "Preferred Stock."

     4.2 Relative Rights and Preferences. The designations, preferences and
rights of the shares of each class of stock which the Corporation is authorized
to issue, and the limitations thereof, are as set forth in the following
provisions of this Section 4.2:

          (a) Common Stock.

               (i) General. The dividend and liquidation rights of the holders
          of the Common Stock are junior to, subject to and qualified by the
          rights of the holders of the Preferred Stock.

               (ii) Dividends. Dividends may be declared and paid on the Common
          Stock from funds lawfully available therefor as and when determined by
          the Board of Directors, subject to any preferential dividend rights of
          any then-outstanding Preferred Stock.

               (iii) Liquidation. In the event of any liquidation, dissolution
          or winding-up of the Corporation, whether voluntary or involuntary,
          the holders of the Common Stock shall be entitled, out of the assets
          of the Corporation available for distribution to its shareholders,
          subject to any preferential rights of any then-outstanding Preferred
          Stock, to share ratably among themselves in proportion to the
          respective amounts that would otherwise be payable in respect of the
          shares


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          held by them upon such distribution if all amounts payable on or with
          respect to such shares were paid in full.

               (iv) Voting. Each holder of Common Stock of record shall have one
          vote for each share of stock outstanding in his name and on the books
          of the Corporation except that, in the election of directors, he shall
          have the right to vote each such share for as many persons as there
          are directors to be elected. Cumulative voting shall not be allowed in
          the election of directors or for any other purpose.

          (b) Series Preferred Stock. The designations, dividend rights, voting
          powers, rights on liquidation and other preferences and relative,
          participating, optional or other special rights and the
          qualifications, limitations or restrictions of the shares of the
          series of Preferred Stock shall be as follows:

               (i) Certain Definitions. Unless the context otherwise requires,
          for purposes of Section 4.2(b), the terms defined in this Section
          4.2(b)(i) shall have the meanings herein specified (with terms defined
          in the singular having comparable meanings when used in the plural).

                    "Common Stock" shall mean the common stock, $0.001 par value
          per share, of the Corporation.

                    "Disposition Proceeds" shall have the meaning set forth in
          Section 4.2(b)(iii)(C).

                    "Equivalent Common Dividend" shall have the meaning set
          forth in Section 4.2(b)(ii).

                    "Liquidation Preferences" shall have the meaning set forth
          in Section 4.2(b)(iii)(C).

                    "Mandatory Conversion Date" shall have the meaning set forth
          in Section 4.2(b)(iv)(B).

                    "Preferred Stock" shall mean any authorized series of
          preferred stock of the Corporation, including, without limitation, the
          Series A Preferred Stock, the Series B Preferred Stock and the Series
          C Preferred Stock.

                    "Qualifying IPO" shall mean an underwritten public offering
          pursuant to an effective registration statement under the Securities
          Act of 1933 of shares of Common Stock, at a price per share of at
          least $8.00, and the aggregate


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          gross proceeds of which equal or exceed $20,000,000 (before
          underwriting discounts and commissions).

                    "Required Consent" shall mean (i) the affirmative vote of
          the holders of at least 66 2/3% of the outstanding shares of Preferred
          Stock or a series of such Preferred Stock, as the case may be, taken
          at a duly called meeting of the holders of such Preferred Stock or
          series of such Preferred Stock; or (ii) the written consent of the
          holders of at least 66 2/3% of the outstanding shares of Preferred
          Stock or a series of such Preferred Stock, as the case may be.

                    "Series A Initial Purchase Price" shall mean $1.00 per share
          (adjusted for stock dividends, stock splits, reverse stock splits,
          combinations and the like).

                    "Series A Liquidation Preference" shall have the meaning set
          forth in Section 4.2(b)(iii)(C).

                    "Series A Preferred Stock" shall mean the Series A Preferred
          Stock, $0.001 par value per share, of the Corporation.

                    "Series B Initial Purchase Price" shall mean $2.50 per share
          (adjusted for stock dividends, stock splits, reverse stock splits,
          combinations and the like).

                    "Series B Liquidation Preference" shall have the meaning set
          forth in Section 4.2(b)(iii)(C).

                    "Series B Preferred Stock" shall mean the Series B Preferred
          Stock, $0.001 par value per share, of the Corporation.

                    "Series C Initial Purchase Price" shall mean $6.00 per share
          (adjusted for stock dividends, stock splits, reverse stock splits,
          combinations and the like).

                    "Series C Liquidation Preference" shall have the meaning set
          forth in Section 4.2(b)(iii)(C).

                    "Series C Preferred Stock" shall mean the Series C Preferred
          Stock, $0.001 par value per share, of the Corporation.

                    "Subordinate Stock" shall mean any class or series of
          capital stock of the Corporation, however designated, which is junior
          in right to the Preferred Stock, including without limitation the
          Common Stock and any other capital stock


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          of the Corporation that is not entitled to receive (i) any dividends
          unless all dividends required to have been paid or declared and set
          apart for payment on the Preferred Stock shall have been so paid or
          declared and set apart for payment; or (ii) any assets upon
          liquidation, dissolution or winding up of the affairs of the
          Corporation until the Preferred Stock shall have received the entire
          amount to which such stock is entitled upon such liquidation,
          dissolution or winding up.

               (ii) Dividends. If at any time during which any shares of Series
          A Preferred Stock, Series B Preferred Stock or Series C Preferred
          Stock remain outstanding the Corporation declares, pays or sets apart
          for payment any dividend on the Common Stock, whether in cash,
          property or otherwise, each holder of shares of Series A Preferred
          Stock, Series B Preferred Stock or Series C Preferred Stock shall be
          entitled to receive the equivalent per share dividend (an "Equivalent
          Common Dividend"), when and as declared by the Corporation, based on
          the number of shares of Common Stock into which each share of
          Preferred Stock is convertible on the record date. For any Equivalent
          Common Dividend that is not paid in full when due, then on such due
          date such accrued and unpaid Equivalent Common Dividend shall be added
          to the Liquidation Preference of the Preferred Stock effective at such
          due date when such Equivalent Common Dividend was not paid. If any
          accrued and unpaid Equivalent Common Dividend is so added to the
          Liquidation Preference, such Liquidation Preference shall be reduced,
          effective on the date of payment, to the extent any accrued and unpaid
          Equivalent Common Dividend is subsequently paid.

               (iii) Distributions Upon Liquidation, Dissolution or Winding Up.

                    (A) The Corporation shall deliver to each holder of
               Preferred Stock notice of any Disposition (as defined in Section
               4.2(b)(iii)(B)) at least 90 days prior to such event, which
               notice shall state all material facts and common terms relating
               to such Disposition, including, without limitation, (1) the
               nature of such Disposition, including, without limitation, the
               amount, terms and conditions of payment to the holders of the
               Preferred Stock and the holders of Common Stock in connection
               with such Disposition; (2) the date on which such Disposition
               shall occur; and (3) the procedures that must be followed (and
               the latest date that such procedures must be completed) in order
               for such holder to effect a conversion of shares of Preferred
               Stock into shares of Common Stock, if such a conversion is so
               desired.

                    (B) The following events shall be considered a "Disposition"
               under this Section:

                         (1) any consolidation or merger of the Corporation with
                    or into any other corporation or other entity or person, or
                    any other


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                    corporate reorganization, in which the stockholders of the
                    Corporation immediately prior to such consolidation, merger
                    or reorganization, own less than 50% of the Corporation's
                    voting power immediately after such consolidation, merger or
                    reorganization, or any transaction or series of related
                    transactions in which in excess of 50% of the Corporation's
                    voting power is transferred;

                         (2) a sale, lease or other disposition of all or
                    substantially all of the assets of the Corporation; or

                         (3) any voluntary or involuntary liquidation,
                    dissolution or other winding up of the affairs of the
                    Corporation.

                    (C) In the event of any such Disposition, before any payment
               or distribution shall be made to the holders of the Common Stock,
               the holders of Preferred Stock shall be entitled to be paid out
               of the Disposition Proceeds in cash, or, if the Corporation does
               not have sufficient cash on hand to pay such amounts, property of
               the Corporation at its fair market value as determined by the
               Board of Directors, an amount (the "Series A Liquidation
               Preference", the "Series B Liquidation Preference" and the
               "Series C Liquidation Preference") equal to either the Series A
               Initial Purchase Price, the Series B Initial Purchase Price or
               the Series C Initial Purchase Price, as appropriate, plus any
               accrued but unpaid dividends. If upon any such Disposition, the
               remaining assets of the Corporation available for distribution to
               its shareholders shall be insufficient to pay the holders of the
               Preferred Stock the full amount of their respective Liquidation
               Preferences, the holders of the Preferred Stock shall share
               ratably among themselves in any distribution of the remaining
               assets and funds of the Corporation in proportion to the
               respective amounts that would otherwise be payable in respect of
               the shares held by them upon such distribution if all amounts
               payable on or with respect to such shares were paid in full.

               (iv) Conversion Rights.

                    (A) Conversion at the Option of the Holder. The holders of
               the Preferred Stock shall have the right, at their option, to
               convert shares of Preferred Stock into shares of Common Stock of
               the Corporation at any time and from time to time on the
               following terms and conditions:

                         (1) Each share of Preferred Stock shall be converted at
                    the option of the holder thereof, without the payment of
                    additional


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                    consideration, into such number of fully paid and
                    nonassessable shares of Common Stock as is determined by
                    dividing the Series A Initial Purchase Price, the Series B
                    Initial Purchase Price or the Series C Initial Purchase
                    Price, as applicable, by the Series A Conversion Rate, the
                    Series B Conversion Rate or the Series C Conversion Rate,
                    respectively, in effect at the time of conversion. For
                    purposes of this section, the "Series A Conversion Rate",
                    the "Series B Conversion Rate" and the "Series C Conversion
                    Rate" shall initially shall be equal to the Series A Initial
                    Purchase Price, Series B Initial Purchase Price and the
                    Series C Initial Purchase Price, respectively, and shall
                    each be subject to adjustment as provided in Section
                    4.2(b)(iv)(C)(2) below.

                         (2) The Corporation shall not issue, in connection with
                    the conversion of shares of Preferred Stock, certificates
                    for fractional shares, but in lieu thereof shall pay to any
                    person who would otherwise be entitled thereto an amount of
                    cash equal to such fraction multiplied by the fair value of
                    one share of Common Stock, as determined by the Board of
                    Directors, whose determination shall be conclusive.

                         (3) In order for any holder of shares of Preferred
                    Stock to convert the same into Common Stock, he shall
                    surrender the certificate or certificates therefor, duly
                    endorsed, at the office of the Corporation and shall give
                    written notice to the Corporation that he elects to convert
                    all or part of the shares represented by the certificate or
                    certificates and shall state in writing therein the name or
                    names in which he wishes the certificate or certificates for
                    Common Stock to be issued. The Corporation shall, as soon as
                    practicable thereafter, issue and deliver to such holder of
                    shares of Preferred Stock, or to his nominee or nominees,
                    certificates for the full number of shares of Common Stock
                    to which he shall be entitled as aforesaid. Shares of
                    Preferred Stock shall be deemed to have been converted as of
                    the date of the surrender of such shares for conversion as
                    provided above, and the person or persons entitled to
                    receive Common Stock issuable upon such conversion shall be
                    treated for all purposes as the record holder or holders of
                    such Common Stock on such date.

                         (4) If a holder converts shares of Preferred Stock, the
                    Corporation shall pay any documentary , stamp or similar
                    issue or transfer tax due on the issue of shares of Common
                    Stock upon the conversion; provided, however, that the
                    holder shall pay any such


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                    tax that is due because the shares are issued in a name
                    other than the holder's name pursuant to Section
                    4.2(b)(iv)(A)(3).

                    (B) Mandatory Conversion. Subject to the adjustments set
               forth in Section 4.2(b)(iv)(C), each share of Preferred Stock
               shall be converted automatically into shares of the Corporation's
               Common Stock at the Series A Conversion Rate, Series B Conversion
               Rate or Series C Conversion Rate, as applicable, on the date a
               Qualifying IPO is consummated (the "Mandatory Conversion Date").
               At least 60 days prior to the Mandatory Conversion Date, the
               Corporation shall (1) notify all holders of the Preferred Stock
               of such event; (2) demand that all shares representing the
               Preferred Stock be returned to the Corporation's offices or to
               the designated transfer agent; and (3) pay any transfer or
               similar tax with respect to the conversion, if any. As soon as
               practical but in any event within 30 days after the Mandatory
               Conversion Date, the Corporation shall deliver a certificate to
               and in the name of the holder of the Preferred Stock for the
               number of shares of Common Stock issuable upon the conversion and
               a check in an amount calculated in accordance with Section
               4.2(b)(iv)(A)(2) for any fractional shares, if any, for the
               shares of Preferred Stock represented by the certificate. The
               name of the person in which the Preferred Stock was issued shall
               be treated as the stockholder of record of the Common Stock in
               which the Preferred Stock was converted on and after the
               Mandatory Conversion Date. Adjustment (or cash payment, if
               applicable) shall be made for accrued and previously declared and
               unpaid dividends, as of the Mandatory Conversion Date, on shares
               of Preferred Stock converted pursuant to this Section
               4.2(b)(iv)(B). Upon such conversion, the rights of the holders of
               Preferred Stock with respect to the shares of Preferred Stock so
               converted shall cease.

                    (C) Certain Matters With Respect to Conversion.

                         (1) The Corporation has reserved and shall continue to
                    reserve out of its authorized but unissued Common Stock or
                    its Common Stock held in treasury enough shares of Common
                    Stock to permit the conversion of the Preferred Stock in
                    full. All shares of Common Stock that may be issued upon
                    conversion of Preferred Stock shall be duly authorized,
                    validly issued, fully paid and nonassessable.

                         (2) The Series A Conversion Rate, Series B Conversion
                    Rate and Series C Conversion Rate shall be subject to
                    adjustment as follows:


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                         (a) In case the Corporation shall (i) pay a dividend or
                    make a distribution on its Common Stock in shares of Common
                    Stock of the Corporation, (ii) subdivide or split its
                    outstanding Common Stock, or (iii) combine the outstanding
                    Common Stock into a smaller number of shares, the Series A
                    Conversion Rate, Series B Conversion Rate and Series C
                    Conversion Rate following the effective date of such event
                    shall be equal to the product of the Series A Conversion
                    Rate, Series B Conversion Rate or Series C Conversion Rate,
                    respectively, in effect immediately prior to such adjustment
                    multiplied by a fraction, the denominator of which is the
                    number of shares of Common Stock outstanding immediately
                    after such event and the numerator of which is the number of
                    shares outstanding immediately prior to such event.

                         (b) In the event the Corporation at any time or from
                    time to time shall make or issue, or fix a record date for
                    the determination of holders of Common Stock entitled to
                    receive a dividend or other distribution payable in
                    securities of the Corporation other than shares of Common
                    Stock, then and in each such event provision shall be made
                    so that the holders of Preferred Stock shall receive upon
                    conversion thereof in addition to the number of shares of
                    Common Stock receivable thereupon, the amount of securities
                    of the Corporation that they each would have received had
                    the Preferred Stock been converted into Common Stock on the
                    date of such event and had they each thereafter, during the
                    period from the date of such event to and including the
                    conversion date, retained such securities receivable by them
                    as aforesaid during such period, giving application to all
                    adjustments called for during such period under this section
                    with respect to the rights of the holders of Preferred
                    Stock; provided, however, that no such adjustment shall be
                    made if the holders of Preferred Stock simultaneously
                    receive a dividend or other distribution of such securities
                    as they would have received if all outstanding shares of
                    Preferred Stock had been converted into Common Stock on the
                    date of such event.

                         (c) If Common Stock issuable upon the conversion of
                    Preferred Stock shall be changed into the same or a
                    different number of shares of any class or classes of stock,
                    whether by capital reorganization, reclassification, or
                    otherwise (other than a subdivision or combination of shares
                    or stock dividend provided for above, or a reorganization,
                    merger, consolidation, or sale of assets provided for
                    below), then and in each such event the holder of each such
                    share of Preferred Stock shall have the right thereafter


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                    to convert such share into the kind and amount of shares of
                    stock and other securities and property receivable upon such
                    reorganization, reclassification, or other change, by
                    holders of the number of shares of Common Stock into which
                    such share of Preferred Stock might have been converted
                    immediately prior to such reorganization, reclassification,
                    or change, all subject to further adjustment as provided
                    herein.

                         (d) Adjustments to the Series A Conversion Rate, Series
                    B Conversion Rate and Series C Conversion Rate shall also be
                    made for certain dilutive issuances of additional shares of
                    capital stock by the Corporation as set forth in this
                    Section 4.2(b)(iv)(C)(2)(d).

                         (i)  Special Definitions. For purposes of this Section
                              4.2(b)(iv)(C)(2)(d), the following definitions
                              shall apply:

                              (A) "Option" means rights, options, warrants or
                              other securities convertible into or exchangeable
                              or exercisable for shares of Common Stock or
                              Preferred Stock.

                              (B) "Additional Shares of Stock" (i) with respect
                              to the Series A Preferred Stock, all shares of
                              Common Stock or Preferred Stock issued by the
                              Corporation after the date that shares of Series A
                              Preferred Stock are first issued by the
                              Corporation (the "Series A Initial Issue Date")
                              for which the consideration per share (determined
                              pursuant to Section 4.2(b)(iv)(C)(2)(d)(iii)) is
                              less than the Series A Conversion Rate in effect
                              on the date of, and immediately prior to, the
                              issuance of such Additional Shares of Stock; (ii)
                              with respect to the Series B Preferred Stock, all
                              shares of Common Stock or Preferred Stock issued
                              by the Corporation after the date that shares of
                              Series B Preferred Stock are first issued by the
                              Corporation (the "Series B Initial Issue Date")
                              for which the consideration per share (determined
                              pursuant to Section 4.2(b)(iv)(C)(2)(d)(iii)) is
                              less than the Series B Conversion Rate in effect
                              on the date of, and immediately prior to, the
                              issuance of such Additional Shares of Stock;


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                              (iii) with respect to the Series C Preferred
                              Stock, all shares of Common Stock or Preferred
                              Stock issued by the Corporation after the date
                              that shares of Series C Preferred Stock are first
                              issued by the Corporation (the "Series C Initial
                              Issue Date") for which the consideration per share
                              (determined pursuant to Section 4.2(b)(iv)(C)(2)
                              (d)(iii)) is less than the Series C Conversion
                              Rate in effect on the date of, and immediately
                              prior to, the issuance of such Additional Shares
                              of Stock, provided, however that in the case of
                              any series of Preferred Stock, not including any
                              shares of Common Stock or Preferred Stock issued
                              or issuable:

                                   (I) upon exercise of any Options outstanding
                                   on the Series C Initial Issue Date; provided,
                                   however that if the Corporation, after the
                                   Series C Initial Issue Date, amends the
                                   exercise price or the number of shares
                                   covered by any Options outstanding on the
                                   Series C Initial Issue Date, then such
                                   Options, as so amended, shall be deemed to
                                   have been issued after the Series C Initial
                                   Issue Date;

                                   (II) by reason of a dividend, stock split,
                                   split-up or other distribution on shares of
                                   Common Stock that is covered by Section
                                   4.2(b)(iv)(C)(2)(b) or (c) above;

                                   (III) upon exercise of Options granted to
                                   employees or directors of, or consultants to,
                                   the Corporation pursuant to a valid option
                                   plan adopted by the Corporation;

                                   (IV) to employees or directors of, or
                                   consultants to, the Corporation pursuant to a
                                   valid stock purchase plan adopted by the
                                   Corporation; or

                                   (V) upon exercise of warrants or other
                                   securities convertible into Common or
                                   Preferred Stock issued in connection with a
                                   credit facility, but not to exceed an
                                   aggregate


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                                   of $200,000 in value (as determined by the
                                   exercise price) in any six month period.

                         (ii) Adjustment of Conversion Rates Upon Issuance of
                              Additional Shares of Stock. In the event the
                              Corporation shall at any time issue Additional
                              Shares of Stock with respect to the Series A
                              Preferred Stock, the Series B Preferred Stock or
                              the Series C Preferred Stock, then and in such
                              event, such Series A Conversion Rate, Series B
                              Conversion Rate or Series C Conversion Rate, as
                              applicable, shall be reduced, concurrently with
                              such issuance, to a price (calculated to the
                              nearest cent) determined by multiplying the Series
                              A Conversion Rate, the Series B Conversion Rate or
                              Series C Conversion Rate, as applicable, then in
                              effect by a fraction:

                              (A) the numerator of which shall be (1) the number
                              of shares of Common Stock outstanding immediately
                              prior to such issue plus (2) the number of shares
                              of Common Stock which the aggregate consideration
                              received or to be received by the Corporation for
                              the total number of Additional Shares of Stock so
                              issued would purchase at such Series A Conversion
                              Rate, Series B Conversion Rate or Series C
                              Conversion Rate, as applicable; and

                              (B) the denominator of which shall be the number
                              of shares of Common Stock outstanding immediately
                              prior to such issue plus the number of such
                              Additional Shares of Stock so issued.

                        (iii) Determination of Consideration. For purposes of
                              this Section 4.2(b)(iv)(C)(3)(d)(iii), the
                              consideration received by the Corporation for the
                              issue of any Additional Shares of Stock shall be
                              computed as follows:

                              (A) in case of the issuance of shares of Common
                              Stock for cash, the consideration shall be the
                              amount of such cash, provided that in no case
                              shall any deduction be made for any commissions,


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<PAGE>   14


                              discounts or other expenses incurred by the
                              Corporation for any underwriting of the issue or
                              otherwise in connection therewith;

                              (B) in the case of the issuance of shares of
                              Common Stock for a consideration in whole or in
                              part other than cash, the consideration other than
                              cash shall be deemed to be the fair market value
                              thereof as determined by the Board of Directors of
                              the Corporation in its reasonable judgment
                              exercised in good faith (irrespective of the
                              accounting treatment thereof); and

                              (C) in the case of the issuance of Options, the
                              aggregate consideration received therefor shall be
                              deemed to be the consideration received by the
                              Corporation for the issuance of such Options plus
                              the additional minimum consideration, if any, to
                              be received by the Corporation upon the conversion
                              or exchange or exercise thereof (the consideration
                              in each case to be determined in the same manner
                              as provided in clauses (i) and (ii) of this
                              Section).

                    (3) Whenever the number of shares of Common Stock into which
                    any share of Preferred Stock is convertible is adjusted, the
                    Corporation shall promptly mail to holders of the affected
                    Preferred Stock, first class, postage prepaid, a notice of
                    the adjustment. The Corporation shall file with the transfer
                    agent, if any, for the Preferred Stock a certificate from
                    the Corporation's independent public accountants briefly
                    stating the facts requiring the adjustment and the manner of
                    computing it. Subject to Section 4.2(b)(iv)(C)(9) below, the
                    certificate shall be conclusive evidence that the adjustment
                    is correct.

                    (4) The adjustments herein provided for shall be made
                    successively when the event giving rise to such adjustment
                    occurs and shall become effective immediately following the
                    record date for any event for which a record date is
                    designated and on the effective date for any other event.

                    (5) Shares of Preferred Stock that have been converted as
                    provided herein shall revert to the status of authorized but
                    unissued shares of Preferred Stock.


                                       13
<PAGE>   15


                    (6) For purposes of any computation of the number of shares
                    of Common Stock outstanding, such computation shall be made
                    assuming conversion of all then outstanding shares of
                    Preferred Stock and all outstanding currently exercisable
                    warrants and vested options.

                    (7) No adjustment in the number of shares of Common Stock
                    into which each share of Preferred Stock is convertible need
                    be made unless the adjustment would require an increase of
                    at least one-half of one percent (.5%) in the number of
                    shares of Common Stock into which each share of Preferred
                    Stock is convertible. Any adjustments that are not made
                    shall be carried forward and taken into account in any
                    subsequent adjustment. All calculations under this Section
                    4.2(b)(iv)(C) shall be made to the nearest cent or to the
                    nearest 1/100th of a share, as the case may be.

                    (8) In any case in which this Section 4.2(b)(iv)(C) shall
                    require that an adjustment as a result of any event become
                    effective from and after a record date, the Corporation may
                    elect to defer until after the occurrence of such event (a)
                    the issuance to the holder of any shares of Preferred Stock
                    converted after such record date and before the occurrence
                    of such event of the additional shares of Common Stock
                    issuable upon such conversion over and above the shares
                    issuable immediately prior to adjustment; and (b ) the
                    delivery of a check for any remaining fractional shares as
                    provided in Section 4.2(b)(iv)(A)(2) above.

                    (9) Except as provided in the immediately following
                    sentence, any determination that the Corporation or its
                    Board of Directors must make pursuant to this Section
                    4.2(b)(iv)(C) shall be conclusive. Whenever the Corporation
                    or its Board of Directors shall be required to make a
                    determination under this Section 4.2(b)(iv)(C), such
                    determination shall be made in good faith and may be
                    challenged in good faith by the holders of a majority of the
                    affected Series A Preferred Stock, Series B Preferred Stock
                    and/or Series C Preferred Stock, as applicable, and any
                    dispute shall be resolved promptly (and in no event later
                    than 90 days after any challenge), at the Corporation's
                    expense, by an investment banking firm of recognized
                    national standing selected by the Corporation and acceptable
                    to such holders of Series A Preferred Stock, Series B
                    Preferred Stock and/or Series C Preferred Stock, as
                    applicable. Any such determination shall be deemed approved
                    if the requisite holders have not notified the Corporation
                    of any challenge within


                                       14
<PAGE>   16


                    30 days after receiving notice (including a statement in
                    reasonable detail of the bases therefor) of such
                    determination.

               (v) Voting Rights.

                    (A) Except as otherwise set forth in this Section 4.2(b)(v)
               or as otherwise required by law, each share of Preferred Stock
               issued and outstanding shall have the right to vote on all
               matters presented to the holders of the Common Stock for vote in
               the number of votes equal at any time to the number of shares of
               Common Stock into which each share of Preferred Stock would then
               be convertible, and the holders of the Preferred Stock shall vote
               with the holders of the Common Stock as a single class.

                    (B) In addition to any vote or consent of shareholders or
               directors required by law or this Amended and Restated
               Certificate of Incorporation, so long as any originally issued
               Series A Preferred Stock, Series B Preferred Stock or Series C
               Preferred Stock remains outstanding, the Required Consent of the
               holders of the Series A Preferred Stock, Series B Preferred Stock
               and/or Series C Preferred Stock shall be necessary for effecting,
               validating or permitting:

                         (1) any amendment, alteration or repeal of any of the
                    provisions of the Corporation's Amended and Restated
                    Certificate of Incorporation or the Bylaws affecting the
                    rights, powers and preferences of the Series A Preferred
                    Stock, Series B Preferred Stock or Series C Preferred Stock,
                    as applicable, provided, however that the Required Consent
                    for this subparagraph (1) shall be of the holders of Series
                    A Preferred Stock, Series B Preferred Stock or Series C
                    Preferred Stock, voting as separate classes and only if such
                    series is affected; or

                         (2) any consolidation or merger of the Corporation with
                    or into any other corporation, or any other corporate
                    reorganization, in which the stockholders of the Corporation
                    immediately prior to such consolidation, merger or
                    reorganization, own less than 50% of the Corporation's
                    voting power immediately after such consolidation, merger or
                    reorganization; any transaction or series of related
                    transactions in which excess of 50% of the Corporation's
                    voting power is transferred; any reclassification or
                    recapitalization of any capital stock of the Corporation;
                    any dissolution, liquidation, or winding up of the
                    Corporation; or any sale of more than 50% of the assets of
                    the Corporation, or any agreement to become so obligated;
                    provided, however that the Required Consent for this
                    subparagraph (2) shall be of the holders


                                       15
<PAGE>   17


                    of Series A Preferred Stock, Series B Preferred Stock and
                    Series C Preferred Stock, voting together as a single class.

                    (C) The rights of the holders of the Preferred Stock set
               forth in this Section 4.2(b)(v) may be exercised either at a
               special meeting of the holders of each series of Preferred Stock,
               called as hereinafter provided, or at any annual meeting of
               stockholders held for the purpose of electing directors, and
               thereafter at such annual meetings, special meetings or by the
               written consent of the holders of Preferred Stock, as applicable.

                    (D) A special meeting of the holders of Preferred Stock for
               purposes of voting on matters with respect to which the holders
               of such shares are entitled to vote as a class may be called by
               the Secretary of the Corporation or by a holder of Preferred
               Stock designated in writing by the holders of record of 10% of
               the shares of such series of Preferred Stock then outstanding.
               Such meeting may be called at the expense of the Corporation by
               any such person. At any meeting of the holders of each series of
               Preferred Stock, the presence in person or by proxy of the
               holders of a majority of the shares of such series of Preferred
               Stock then outstanding shall constitute a quorum of the such
               series of Preferred Stock.

               (vi) Miscellaneous.

                    (A) Headings of Sections. The headings of the various
               subdivisions hereof are for convenience of reference only and
               shall not affect the interpretation of any of the provisions
               hereof.

                    (B) Severability of Provisions. If any voting powers,
               preferences and relative, participating, optional and other
               special rights of the Preferred Stock and qualifications,
               limitations and restrictions thereof set forth herein (as may be
               amended from time to time) is invalid, unlawful or incapable of
               being enforced by reason of any rule of law or public policy, all
               other voting powers, preferences and relative, participating,
               optional and other special rights of Preferred Stock and
               qualifications, limitations and restrictions thereof set forth
               herein (as so amended) that can be given effect without the
               invalid, unlawful or unenforceable voting powers, preferences and
               relative, participating, optional and other special rights of
               Preferred Stock and qualifications, limitations and restrictions
               thereof shall, nevertheless, remain in full force and effect, and
               no voting powers, preferences and relative, participating,
               optional or other special rights of Preferred Stock and
               qualifications, limitations and restrictions thereof herein set
               forth shall be deemed dependent upon any other such voting
               powers, preferences and relative,


                                       16
<PAGE>   18


               participating, optional or other special rights of Preferred
               Stock and qualifications, limitations and restrictions thereof
               unless so expressed herein.

(c) Other Series of Preferred Stock. Subject to the approval requirements
contained herein, the Board of Directors is hereby expressly authorized by
resolution from time to time adopted providing for the issuance of preferred
stock, to fix and state the designations, powers, preferences and relative,
optional and other special rights of the shares of each series of preferred
stock, and the qualifications, limitations and restrictions thereof, including
(but without limiting the generality of the foregoing) any of the following with
respect to which the Board of Directors shall determine to make effective
provisions:

          (i) the distinctive name and serial designation;

          (ii) the dividend payment dates;

          (iii) the rate or rates at which dividends if any shall be paid;

          (iv) whether dividends are to be cumulative or noncumulative, and any
     preferential or other special rights with respect to the payment of
     dividends;

          (v) whether any series shall be redeemable and if so, the terms,
     conditions and manner of redemption, and the redemption price or prices;

          (vi) he rights of any series on voluntary or involuntary liquidation,
     dissolution or winding up, including the amounts or amounts of preferential
     or other payments to which any series is entitled over any other series or
     over the common stock;

          (vii) any sinking fund or other retirement provisions and the extent
     to which the charges therefor are to have priority over the payment of
     dividends on or the making of sinking fund or other like retirement
     provisions for shares of any other series or over dividends on the common
     stock;

          (viii) the number of shares of such series;

          (ix) the voting rights, if any, for such series; and

          (x) the conversion rights, if any, for such series.

     Unless otherwise provided in the resolution of the Board of Directors
providing for the issue thereof, the shares of any series of preferred stock
which shall be issued and thereafter


                                       17
<PAGE>   19


acquired by the Corporation through purchase, redemption, conversion or
otherwise may by resolution of the Board of Directors be returned to the status
of authorized but unissued preferred stock of the same or other series. Unless
otherwise provided in the resolution of the Board of Directors providing for the
issue thereof, the number of authorized shares of stock of any such series may
be increased or decreased (but not below the number of shares thereof then
outstanding) by resolution by the Board of Directors. In case the number of
shares of any such series of preferred stock shall be decreased, the shares
representing such decrease shall, unless otherwise provided in the resolution of
the Board of Directors providing for the issuance thereof, resume the status of
authorized but unissued preferred stock, undesignated as to series.

                                    ARTICLE V

                             LIMITATION ON LIABILITY

     To the fullest extent permitted by the General Corporation Law of Delaware,
as the same exists or may hereafter be amended, a director of the Corporation
shall not be liable to the Corporation or its stockholders for monetary damages
for breach of fiduciary duty as a director. Any repeal or modification of this
Article by the stockholders of the Corporation shall be prospective only and
shall not adversely affect any right or protection of a director of the
Corporation existing at the time of such repeal or modification.

                                   ARTICLE VI

                                 INDEMNIFICATION

     Each person who is or was a director or officer of the Corporation, and
each such person who is or was serving at the request of the Corporation as a
director or officer of another Corporation, or in a similar capacity of a
partnership, joint venture, trust or other enterprise, including service with
respect to employee benefit plans maintained or sponsored by the Corporation
(including the heirs, executors, administrators and estate of such person) shall
be indemnified by the Corporation, in accordance with the procedures specified
in the Bylaws of the Corporation, to the fullest extent permitted from time to
time by the General Corporation Law of the State of Delaware. The Corporation
may, to the extent authorized from time to time by the Board of Directors, grant
rights to indemnification and to the advancement of expenses to any employee or
agent of the Corporation to the fullest extent of the provisions of this Article
with respect to the indemnification and advancement of expenses of directors and
officers of the Corporation, without limiting the generality of the foregoing,
the Corporation may enter into one or more agreements with any person that
provide for indemnification and advancement of expenses greater or different
than that provided in this Article. No amendment or repeal of this Article shall
adversely affect any right or protection existing under or pursuant to this
Article immediately before the amendment or repeal.


                                       18
<PAGE>   20


                                   ARTICLE VII

                              ELECTION OF DIRECTORS

     Elections of directors need not be by written ballot unless the bylaws of
the Corporation so provide.

                                  ARTICLE VIII

                              AMENDMENTS TO BYLAWS

     The Board of Directors of the Corporation is expressly authorized to make,
alter or repeal the bylaws of the Corporation.

                            [signature page follows]


                                       19
<PAGE>   21


     IN WITNESS WHEREOF, this Amended and Restated Certificate of Incorporation
of the Corporation has been executed this 31st day of August 2000.

                                      ARRAY BIOPHARMA INC.

                                      By: /s/ ROBERT CONWAY
                                          --------------------------------------
                                          Robert Conway, Chief Executive Officer



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