VAN KAMPEN FOCUS PORTFOLIOS SERIES 250, 497J, 2000-10-10

VAN KAMPEN FOCUS PORTFOLIOS SERIES 250
497J, 2000-10-10

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                                 October 10, 2000



Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C. 20549-1004

Attn:  Filing Desk, Stop 1-4

                   Re: Van Kampen Focus Portfolios, Series 250
                       (File No. 333-46078) (CIK No. 1104607)


Gentlemen:

         In accordance with the provisions of Rule 497(j) of Regulation C under
the Securities Act of 1933 (the "Securities Act") this letter serves to certify
that the most recent amendment to the registration statement of Form S-6 for the
above captioned Trust does not differ from that which would have been filed
pursuant to Rule 497(b) of the Securities Act. The most recent amendment to the
registration statement was filed electronically with the Commission on October
3, 2000.

                                                               Very truly yours,


                                                           VAN KAMPEN FUNDS INC.