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<TABLE> <S> <C>
<PAGE>
<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM CURIS, INC.
AND IS QUALIFIED IN ITS ENTIRETY BY REFERENCE TO SUCH FINANCIAL STATEMENTS.
</LEGEND>
<S> <C> <C> <C> <C>
<PERIOD-TYPE> 12-MOS 12-MOS 12-MOS 9-MOS
<FISCAL-YEAR-END> DEC-31-1999 DEC-31-1998 DEC-31-1997 DEC-31-1999
<PERIOD-START> JAN-01-1999 JAN-01-1998 JAN-01-1997 JAN-01-1999
<PERIOD-END> DEC-31-1999 DEC-31-1998 DEC-31-1997 SEP-30-1999
<CASH> 2,751,069 17,738,044 0 0
<SECURITIES> 18,619,516 40,197,407 0 0
<RECEIVABLES> 60,296 669,232 0 0
<ALLOWANCES> 0 0 0 0
<INVENTORY> 0 0 0 0
<CURRENT-ASSETS> 21,577,645 58,905,584 0 0
<PP&E> 1,846,137 1,225,200 0 0
<DEPRECIATION> (519,766) (201,094) 0 0
<TOTAL-ASSETS> 28,892,291 66,164,057 0 0
<CURRENT-LIABILITIES> 4,461,317 9,292,483 0 0
<BONDS> 1,009,388 713,459 0 0
0 23,052,787 0 0
0 0 0 0
<COMMON> 190,995 103,372 0 0
<OTHER-SE> 23,311,591 33,001,956 0 0
<TOTAL-LIABILITY-AND-EQUITY> 28,892,291 66,164,057 0 0
<SALES> 0 0 0 0
<TOTAL-REVENUES> 3,211,860 10,429,071 13,086,401 2,405,760
<CGS> 0 0 0 0
<TOTAL-COSTS> 17,086,355 33,692,768 31,868,617 12,540,234
<OTHER-EXPENSES> 0 0 0 0
<LOSS-PROVISION> 0 0 0 0
<INTEREST-EXPENSE> 161,385 327,304 215,815 114,780
<INCOME-PRETAX> 0 0 0 0
<INCOME-TAX> 0 0 0 0
<INCOME-CONTINUING> (12,109,790) (21,395,138) (16,651,673) (8,631,677)
<DISCONTINUED> 0 0 0 0
<EXTRAORDINARY> 0 0 0 0
<CHANGES> 0 0 0 0
<NET-INCOME> (14,505,349) (22,381,725) (16,651,673) (11,027,236)
<EPS-BASIC> (1.36) (2.22) (1.68) (1.04)
<EPS-DILUTED> (1.36) (2.22) (1.68) (1.04)
</TABLE>
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